# 二肽基肽酶-4[编辑]

| Dipeptidyl-peptidase 4 |
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| 人类DPP-4的带状结构图 来自PDB: 1PFQ​. |
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| 有效结构 |
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| PDB | 直系同源检索：PDBe, RCSB
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| PDB查询代码列表 |
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| 1J2E​, 1N1M​, 1NU6​, 1NU8​, 1PFQ​, 1R9M​, 1R9N​, 1RWQ​, 1TK3​, 1TKR​, 1U8E​, 1W1I​, 1WCY​, 1X70​, 2AJL​, 2BGN​, 2BGR​, 2BUB​, 2FJP​, 2G5P​, 2G5T​, 2G63​, 2HHA​, 2I03​, 2I78​, 2IIT​, 2IIV​, 2JID​, 2OAG​, 2OGZ​, 2OLE​, 2ONC​, 2OPH​, 2OQI​, 2OQV​, 2P8S​, 2QJR​, 2QKY​, 2QOE​, 2QT9​, 2QTB​, 2RGU​, 2RIP​, 3BJM​, 3C43​, 3C45​, 3CCB​, 3CCC​, 3D4L​, 3EIO​, 3F8S​, 3G0B​, 3G0C​, 3G0D​, 3G0G​, 3H0C​, 3HAB​, 3HAC​, 3KWF​, 3KWJ​, 3NOX​, 3O95​, 3O9V​, 3OC0​, 3OPM​, 3Q0T​, 3Q8W​, 3QBJ​, 3SWW​, 3SX4​, 3VJK​, 3VJL​, 3VJM​, 3W2T​, 4A5S​, 4DSA​, 4DSZ​, 4DTC​, 4G1F​, 4J3J​, 4JH0​, 4KR0​, 4L72​, 4LKO​, 4N8D​, 4N8E​, 4PNZ​, 4PV7​, 4QZV​

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| 标识 |
| 代号 | DPP4; ADABP; ADCP2; CD26; DPPIV; TP103 |
| 扩展标识 | 遗传学：102720  鼠基因：94919  同源基因：3279  ChEMBL: 284 GeneCards: DPP4 Gene |
| EC編號 | 3.4.14.5 |
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| 基因本体论描述 |
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|  分子功能 | · virus receptor activity
· protease binding
· serine-type endopeptidase activity
· receptor binding
· protein binding
· serine-type peptidase activity
· dipeptidyl-peptidase activity
· identical protein binding
· protein homodimerization activity |
|  细胞成分 | · lysosomal membrane
· plasma membrane
· focal adhesion
· cell surface
· membrane
· integral component of membrane
· apical plasma membrane
· lamellipodium
· endocytic vesicle
· lamellipodium membrane
· membrane raft
· intercellular canaliculus
· extracellular exosome
· invadopodium membrane |
|  生物过程 | · behavioral fear response
· response to hypoxia
· proteolysis
· positive regulation of cell proliferation
· negative regulation of extracellular matrix disassembly
· T cell costimulation
· regulation of cell-cell adhesion mediated by integrin
· locomotory exploration behavior
· psychomotor behavior
· T cell activation
· endothelial cell migration
· viral entry into host cell |
| Sources: Amigo / QuickGO |

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| RNA表达模式 |
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| 更多表达数据 |
| 直系同源体 |
| 物种 | **人类** | **小鼠** |
| Entrez | 1803 | 13482 |
| Ensembl | ENSG00000197635 | ENSMUSG00000035000 |
| UniProt | P27487 | P28843 |
| mRNA序列 | NM\_001935 | NM\_001159543 |
| 蛋白序列 | NP\_001926 | NP\_001153015 |
| 基因位置 | Chr 2: 161.99 – 162.07 Mb | Chr 2: 62.33 – 62.41 Mb |
| PubMed查询 | [1] | [2] |
| * 查
* 论
* 编
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**二肽基肽酶-4**（dipeptidyl peptidase-4，DPP-4）又称**T细胞表面抗原CD26**，是一种跨膜丝氨酸多肽酶，分布广泛，作用多向。可作为二肽酶水解多肽，从而调节肽类激素、神经肽、细胞因子和生长因子的活性，另可作为表面抗原与其他分子或蛋白共同合作，介导细胞与基质、细胞与细胞之间的相互作用。在免疫激活、炎症反应和肿瘤发生中起到各种调节作用。

二肽基肽酶-4由*DPPP4*基因编码。DPP4与ATRN、FAP、DPP8和DPP9有关联。

## 延伸閱讀

* Ansorge, S.; Bühling, F.; Kähne, T.; Lendeckel, U.; Reinhold, D.; Täger, M.; Wrenger, S. CD26/dipeptidyl peptidase IV in lymphocyte growth regulation. Advances in Experimental Medicine and Biology. 1997, **421**: 127–140  [2021-11-10]. ISSN 0065-2598. PMID 9330689. doi:10.1007/978-1-4757-9613-1\_17. （原始内容存档于2021-11-10）.  （页面存档备份，存于互联网档案馆）
* Reinhold, Dirk; Kähne, Thilo; Steinbrecher, Andreas; Wrenger, Sabine; Neubert, Klaus; Ansorge, Siegfried; Brocke, Stefan. The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity. Biological Chemistry. 2002-07, **383** (7-8): 1133–1138  [2021-11-10]. ISSN 1431-6730. PMID 12437097. doi:10.1515/BC.2002.123. （原始内容存档于2022-04-10）.  （页面存档备份，存于互联网档案馆）
* Sato, Kazuya; Dang, Nam H. CD26: a novel treatment target for T-cell lymphoid malignancies? (Review). International Journal of Oncology. 2003-03, **22** (3): 481–497  [2021-11-10]. ISSN 1019-6439. PMID 12579300. （原始内容存档于2021-11-10）.  （页面存档备份，存于互联网档案馆）
* De Meester, Ingrid; Lambeir, Anne-Marie; Proost, Paul; Scharpé, Simon. Dipeptidyl Peptidase IV Substrates. Back, Nathan (编). Dipeptidyl Aminopeptidases in Health and Disease **524**. Boston, MA: Springer US. 2004: 3–17. ISBN 978-0-306-47717-1. PMID 12675218. doi:10.1007/0-306-47920-6\_1.
* Koch, Sina; Anthonsen, Dorit; Skovbjerg, Hanne; Sjöström, Hans. On the Role of Dipeptidyl Peptidase IV in the Digestion of an Immunodominant Epitope in Celiac Disease. Back, Nathan (编). Dipeptidyl Aminopeptidases in Health and Disease **524**. Boston: Kluwer Academic Publishers. 2004: 181–187. ISBN 978-0-306-47717-1. PMID 12675238. doi:10.1007/0-306-47920-6\_22 （英语）.
* Pro, B.; Dang, N. H. CD26/dipeptidyl peptidase IV and its role in cancer. Histology and Histopathology. 2004-10, **19** (4): 1345–1351  [2021-11-10]. ISSN 0213-3911. PMID 15375776. doi:10.14670/HH-19.1345. （原始内容存档于2022-01-20）.  （页面存档备份，存于互联网档案馆）

## 參考文獻

* The MEROPS online database for peptidases and their inhibitors: S09.003
* 醫學主題詞表（MeSH）：Dipeptidyl-Peptidase+IV
* Banting and Best Diabetes Centre at UT *dpp4*