# 周期蛋白A1[编辑]

| Cyclin A1 周期素A1 |
| --- |
| 标识 |
| 代号 | CCNA1 |
| 扩展标识 | 遗传学：604036  鼠基因：108042  同源基因：31203  ChEMBL: 3609 GeneCards: CCNA1 Gene |
|

| 基因本体论描述 |
| --- |
|  分子功能 | · protein binding
· protein kinase binding |
|  细胞成分 | · nucleoplasm
· cytosol
· microtubule cytoskeleton |
|  生物过程 | · regulation of cyclin-dependent protein serine/threonine kinase activity
· G1/S transition of mitotic cell cycle
· regulation of transcription involved in G1/S phase of mitotic cell cycle
· G2/M transition of mitotic cell cycle
· mitotic cell cycle
· mitosis
· male meiosis I
· spermatogenesis
· cell division |
| Sources: Amigo / QuickGO |

 |
| RNA表达模式 |
|  |
| 更多表达数据 |
| 直系同源体 |
| 物种 | **人类** | **小鼠** |
| Entrez | 8900 | 12427 |
| Ensembl | ENSG00000133101 | ENSMUSG00000027793 |
| UniProt | P78396 | Q61456 |
| mRNA序列 | NM\_001111045 | NM\_007628 |
| 蛋白序列 | NP\_001104515 | NP\_031654 |
| 基因位置 | Chr 13: 37.01 – 37.02 Mb | Chr 3: 55.05 – 55.06 Mb |
| PubMed查询 | [1] | [2] |
| * 查
* 论
* 编
 |

**周期蛋白A1**（英語：Cyclin-A1，或译为**周期素A1**）化学式为：C2357H3670O697N604S23，是一个由人类基因 *CCNA1* 编码的蛋白质。

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白A1表达于睾丸、大脑以及一些严重的白血病细胞系中，现任为其主要功能是控制减数分裂。该周期蛋白与Cdk1和Cdk2两种激酶相结合，但这两种激酶活性完全不相同，前者激酶活性表现于G2期，而后者激酶活性表现于S期，因此在细胞周期中调控了不同的功能。现发现这种周期蛋白可结合到重要的细胞周期调节物上，后者如：Rb家族蛋白、转录因子E2F1以及CDK抑制蛋白中的Kip/Cip家族。

## 相互作用

周期蛋白A1能与E2F1、CDC20、视网膜母细胞瘤蛋白、周期蛋白依赖性激酶2、GPS2MYBL2和GNB2L1发生相互作用。

## 延伸阅读

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* Xu M, Sheppard KA, Peng CY; et al. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.. Mol. Cell. Biol. 1994, **14** (12): 8420–31. PMC 359381 . PMID 7969176.  引文格式1维护：显式使用等标签 (link)
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* Liu D, Matzuk MM, Sung WK; et al. Cyclin A1 is required for meiosis in the male mouse.. Nat. Genet. 1998, **20** (4): 377–80. PMID 9843212. doi:10.1038/3855.  引文格式1维护：显式使用等标签 (link)
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* Müller C, Yang R, Beck-von-Peccoz L; et al. Cloning of the cyclin A1 genomic structure and characterization of the promoter region. GC boxes are essential for cell cycle-regulated transcription of the cyclin A1 gene.. J. Biol. Chem. 1999, **274** (16): 11220–8. PMID 10196209. doi:10.1074/jbc.274.16.11220.  引文格式1维护：显式使用等标签 (link)
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* Müller-Tidow C, Wang W, Idos GE; et al. Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.. Blood. 2001, **97** (7): 2091–7. PMID 11264176. doi:10.1182/blood.V97.7.2091.  引文格式1维护：显式使用等标签 (link)