# 周期蛋白D1

| 周期蛋白D1 |
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| Rendering based on PDB 2W96​. |
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| 有效结构 |
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| PDB | 直系同源检索：PDBe, RCSB
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| PDB查询代码列表 |
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| 2W96​, 2W99​, 2W9F​, 2W9Z​

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| 标识 |
| 代号 | CCND1; BCL1; D11S287E; PRAD1; U21B31 |
| 扩展标识 | 遗传学：168461  鼠基因：88313  同源基因：1334  ChEMBL: 3610 GeneCards: CCND1 Gene |
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| 基因本体论描述 |
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|  分子功能 | · protein kinase activity
· protein binding
· cyclin-dependent protein serine/threonine kinase regulator activity
· enzyme binding
· protein kinase binding
· protein complex binding |
|  细胞成分 | · cyclin-dependent protein kinase holoenzyme complex
· intracellular
· nucleus
· nucleoplasm
· cytosol
· tight junction
· membrane |
|  生物过程 | · G1 phase of mitotic cell cycle
· G1/S transition of mitotic cell cycle
· S phase of mitotic cell cycle
· mitotic cell cycle
· re-entry into mitotic cell cycle
· liver development
· positive regulation of protein phosphorylation
· response to DNA damage stimulus
· lactation
· response to iron ion
· response to X-ray
· response to organic nitrogen
· negative regulation of Wnt receptor signaling pathway
· negative regulation of epithelial cell differentiation
· endoplasmic reticulum unfolded protein response
· organ regeneration
· mitotic G1 DNA damage checkpoint
· response to magnesium ion
· response to vitamin E
· Leydig cell differentiation
· mammary gland epithelial cell proliferation
· positive regulation of mammary gland epithelial cell proliferation
· response to drug
· response to estrogen stimulus
· fat cell differentiation
· response to ethanol
· positive regulation of cyclin-dependent protein kinase activity
· cell division
· response to corticosterone stimulus
· response to calcium ion
· canonical Wnt receptor signaling pathway
· mammary gland alveolus development
· response to UV-A
· regulation of G1/S transition of mitotic cell cycle |
| Sources: Amigo / QuickGO |

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| RNA表达模式 |
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| 更多表达数据 |
| 直系同源体 |
| 物种 | **人类** | **小鼠** |
| Entrez | 595 | 12443 |
| Ensembl | ENSG00000110092 | ENSMUSG00000070348 |
| UniProt | P24385 | P25322 |
| mRNA序列 | NM\_053056 | NM\_007631 |
| 蛋白序列 | NP\_444284 | NP\_031657 |
| 基因位置 | Chr 11: 69.46 – 69.47 Mb | Chr 7: 144.93 – 144.94 Mb |
| PubMed查询 | [1] | [2] |
| * 查
* 论
* 编
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**G1/S-特异性周期蛋白-D1**是一个由人类*CCND1*基因所编码的蛋白质化学式为C1480H2386O450N396S25。

该基因编码的蛋白质属于高度保守的周期蛋白家族，该家族成员的显著特征是贯穿细胞周期，其蛋白质丰度周期性地急剧改变。周期蛋白作为CDK（周期蛋白依赖性激酶）的调节因子。不同的周期蛋白表现出各自独特的表达及降解特性，这有助于每个有丝分裂事件在时间上的协调性。周期蛋白D1这种亚型的周期蛋白与CDK4或CDK6形成复合物并作为它们的调节亚基，这两种周期蛋白依赖性激酶对于G1到S期的转变来说是不可或缺的。该蛋白表现出与抑癌基因Rb有着相互作用，且此基因的表达受Rb的正向调控。周期蛋白D1发生突变、扩增及过表达将会改变细胞周期进程，这些现象常发生在多种肿瘤中并可能导致肿瘤发生。

套细胞淋巴瘤中对周期蛋白D1进行染色的显微图
使用周期蛋白D1进行免疫组化染色可用于诊断套细胞淋巴瘤。

## 另见

* 甲状旁腺腺瘤
* 套细胞淋巴瘤

## 深入阅读

* Akita H. [Prognostic importance of altered expression of cell cycle regulators in lung cancer]. Nippon Rinsho. 2003,. 60 Suppl 5: 267–71. PMID 12101670.
* Chung DC. Cyclin D1 in human neuroendocrine: tumorigenesis. Ann. N. Y. Acad. Sci. 2004, **1014**: 209–17. PMID 15153436. doi:10.1196/annals.1294.022.
* Jain S, Khuri FR, Shin DM. Prevention of head and neck cancer: current status and future prospects. Current Problems in Cancer. 2004, **28** (5): 265–86. PMID 15375804. doi:10.1016/j.currproblcancer.2004.05.003.
* Gladden AB, Diehl JA. Location, location, location: the role of cyclin D1 nuclear localization in cancer. J. Cell. Biochem. 2006, **96** (5): 906–13. PMID 16163738. doi:10.1002/jcb.20613.
* Walker JL, Assoian RK. Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression. Cancer Metastasis Rev. 2006, **24** (3): 383–93. PMID 16258726. doi:10.1007/s10555-005-5130-7.
* Gautschi O, Ratschiller D, Gugger M; et al. Cyclin D1 in non-small cell lung cancer: a key driver of malignant transformation. Lung Cancer. 2007, **55** (1): 1–14. PMID 17070615. doi:10.1016/j.lungcan.2006.09.024.  引文格式1维护：显式使用等标签 (link)
* Li Z, Wang C, Prendergast GC, Pestell RG. Cyclin D1 functions in cell migration. Cell Cycle. 2007, **5** (21): 2440–2. PMID 17106256.
* Tao Zhang, Breslin MB, Lan MS. Zinc Finger Transcription Factor INSM1 Interrupts Cyclin D1 and CDK4 Binding and Induces Cell Cycle Arrest. J. Biol. Chem. 2009, **284** (9): 5574–81. PMC 2645817 . PMID 19124461. doi:10.1074/jbc.M808843200.
* Inaba T, Matsushime H, Valentine M; et al. Genomic organization, chromosomal localization, and independent expression of human cyclin D genes. Genomics. 1992, **13** (3): 565–74. PMID 1386335. doi:10.1016/0888-7543(92)90126-D.  引文格式1维护：显式使用等标签 (link)
* Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ. Identification and cloning of two overexpressed genes, U21B31/PRAD1 and EMS1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene. 1992, **7** (2): 355–61. PMID 1532244.
* Seto M, Yamamoto K, Iida S; et al. Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation. Oncogene. 1992, **7** (7): 1401–6. PMID 1535701.  引文格式1维护：显式使用等标签 (link)
* Rosenberg CL, Wong E, Petty EM; et al. PRAD1, a candidate BCL1 oncogene: mapping and expression in centrocytic lymphoma. Proc. Natl. Acad. Sci. U.S.A. 1991, **88** (21): 9638–42. PMC 52773 . PMID 1682919. doi:10.1073/pnas.88.21.9638.  引文格式1维护：显式使用等标签 (link)
* Xiong Y, Connolly T, Futcher B, Beach D. Human D-type cyclin. Cell. 1991, **65** (4): 691–9. PMID 1827756. doi:10.1016/0092-8674(91)90100-D.
* Withers DA, Harvey RC, Faust JB; et al. Characterization of a candidate bcl-1 gene. Mol. Cell. Biol. 1991, **11** (10): 4846–53. PMC 361453 . PMID 1833629.  引文格式1维护：显式使用等标签 (link)
* Tsujimoto Y, Yunis J, Onorato-Showe L; et al. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation. Science. 1984, **224** (4656): 1403–6. PMID 6610211. doi:10.1126/science.6610211.  引文格式1维护：显式使用等标签 (link)
* Hall M, Bates S, Peters G. Evidence for different modes of action of cyclin-dependent kinase inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to cyclins. Oncogene. 1995, **11** (8): 1581–8. PMID 7478582.
* Tassan JP, Jaquenoud M, Léopold P; et al. Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C. Proc. Natl. Acad. Sci. U.S.A. 1995, **92** (19): 8871–5. PMC 41069 . PMID 7568034. doi:10.1073/pnas.92.19.8871.  引文格式1维护：显式使用等标签 (link)
* Fornaro M, Dell'Arciprete R, Stella M; et al. Cloning of the gene encoding Trop-2, a cell-surface glycoprotein expressed by human carcinomas. Int. J. Cancer. 1995, **62** (5): 610–8. PMID 7665234. doi:10.1002/ijc.2910620520.  引文格式1维护：显式使用等标签 (link)
* Motokura T, Arnold A. PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor-specific rearrangement breakpoint. Genes Chromosomes Cancer. 1993, **7** (2): 89–95. PMID 7687458. doi:10.1002/gcc.2870070205.