# Gonadotropin-oslobađajući hormon

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| Gonadotropin-oslobađajući hormon‎‎ |
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| Identifikatori |
| Simboli | GNRH1; GNRH; GRH; LHRH; LNRH |
| Vanjski ID | OMIM: 152760  MGI: 95789  HomoloGene: 641  GeneCards: GNRH1 Gene |
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| proširiOntologija gena |
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| Molekularna funkcija | • LHRH aktivnost |
| Celularna komponenta | • ekstracelularni region • rastvorna frakcija |
| Biološki proces | • prenos signala • interćelijska signalizacija • razvoj multićelijskih organizama • negativna regulacija ćelijske proliferacije |

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| Pregled RNK izražavanja |
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| podaci |
| Ortolozi |
| Vrsta | **Čovek** | **Miš** |  |
| Entrez | 2796 | 14714 |  |
| Ensembl | ENSG00000147437 | ENSMUSG00000015812 |  |
| UniProt | P01148 | Q14AC4 |  |
| RefSeq (mRNA) | NM\_000825 | NM\_008145 |  |
| RefSeq (protein) | NP\_000816 | NP\_032171 |  |
| Lokacija (UCSC) | Chr 8: 25.33 - 25.34 Mb | Chr 14: 66.7 - 66.7 Mb |  |
| PubMed pretraga | [1] | [2] |  |

**Gonadotropin-oslobađajući hormon** (**GnRH**), takođe poznat kao *LHRH* (engleski: *Luteinizing-hormone-releasing hormone*) i *luliberin*, je trofični peptidni hormon koji je odgovoran za oslobađanje folikul-stimulišućeg hormona (FSH) i luteinizujućeg hormona (LH) iz prednjeg režnja hipofize. GnRH se sintetiše i oslobađa iz neurona hipotalamusa. Ovaj peptid pripada familiji gonadotropin oslobađajućih hormona.

## Formiranje

Gen, *GNRH1*, za GnRH prekurzor je lociran na hromozomu 8. Kod sisara, linearni dekapeptidni krajnji proizvod se sintetiše iz 92-aminokiselinskog prohormona u preoptičkom prednjem hipotalamusu

## Struktura

GnRH strukturu su objasnili Nobelovci Rodžer Guilemin i Andru V. Schali 1977. godine: piroGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2

## GnRH je neurohormon

GnRH se smatra neurohormonom, hormonom koji proizvode specifične neuronske ćelije i otpuštaju ga na njihovim neuronskim završecima. Ključna oblast za GNRH produkciju je preoptička oblast hipotalamusa, koja sadrži većinu GnRH-izlučujućih neurona. GnRH neuroni nastaju u nosu i migriraju u mozak, gde se rasprostiru po medijalnom septumu i hipotalamusu. Oni su povezani vrlo dugim (>1-milimetra dugačkim) dendritima. Oni su grupisani tako da primaju zajednički sinaptički input, što im omogućava da sinhronizuju GnRH oslobađanje.

## Reference

## Literatura

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