# DDR1

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| Diskoidin domen receptor familija, izoforma 1 |
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| Identifikatori |
| Simboli | DDR1; CAK; CD167; DDR; EDDR1; MCK10; NEP; NTRK4; PTK3; PTK3A; RTK6; TRKE |
| Vanjski ID | OMIM: 600408  MGI: 99216  HomoloGene: 68212  GeneCards: DDR1 Gene |
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| Ontologija gena |
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| Molekularna funkcija | • vezivanje nukleotida • aktivnost protein-tirozin kinaze • aktivnost transmembrankog receptora proteinske tirozin kinaze • aktivnost receptora • ATP vezivanje • aktivnost transferaze |
| Celularna komponenta | • integralno sa membranom plazme • membrana |
| Biološki proces | • fosforilacija proteinske aminokiseline • ćelijska adhezija • transmembranki receptor proteinska tirozin kinaza, signalni put |

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| Pregled RNK izražavanja |
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| Ortolozi |
| Vrsta | **Čovek** | **Miš** |  |
| Entrez | 780 | 12305 |  |
| Ensembl | ENSG00000137332 | ENSMUSG00000003534 |  |
| UniProt | Q08345 | O35407 |  |
| RefSeq (mRNA) | NM\_001954 | NM\_007584 |  |
| RefSeq (protein) | NP\_001945 | NP\_031610 |  |
| Lokacija (UCSC) | Chr c6\_COX: 30.99 - 31.01 Mb | Chr 17: 35.29 - 35.31 Mb |  |
| PubMed pretraga | [1] | [2] |  |

**DDR1**, ili **CD167a** (klaster diferencijacije 167a), je ljudski gen koji je pripadnik broj 1 familije receptora s diskoidinskim domenom.

Receptorske tirozinske kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su uključeni u regulaciju ćelijskog rasta, diferencijacije i metabolizma. Protein kodiran ovim genom je RTK koji je široko izražen u normalnim i transformisanim epitelnim ćelijama, i koji je aktiviran kolagenom. Ovaj protein pripada potfamiliji receptora tirozin kinaza koje sadrže homologni region sa *Dictyostelium discoideum* proteinom *diskoidin I* u njihovom ekstracelularnom domenu. Njegova auto-fosforilacija se postiže svim do sada testiranim kolagenima (tip I - VI). *In situ* studije i *Northern-blot* analiza su pokazale da je izražavanje ovog protein ograničeno na epitelske ćelije, posebno u bubrezima, plućima, gastrointestinalnom traktu, i mozgu. Dodatno, ovaj protein je značajno preizražen i u nekoliko ljudskih tumora iz dojki, jajnika, jednjaka, pedijatrijskog mozga. Ovaj gen se nalazi na hromozomu 6p21.3 u blizini nekoliko HLA klasa I gena. Alternativno splajsovanje (engleski: *splicing*) ovog gena proizvodi nekoliko transkriptnih varijanti.

## Reference

## Literatura

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* Vogel W, Brakebusch C, Fässler R, *et al.* (2000). „Discoidin domain receptor 1 is activated independently of beta(1) integrin.”. *J. Biol. Chem.* **275** (8): 5779–84. DOI:10.1074/jbc.275.8.5779. PMID 10681566.
* Foehr ED, Tatavos A, Tanabe E, *et al.* (2000). „Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors.”. *FASEB J.* **14** (7): 973–81. PMID 10783152.
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