# Hemijska biologija

**Hemijska biologija** je naučna disciplina koja delom obuhvata polja hemije, biologije i fizike. Ona se bavi primenom hemijkih tehnika, oruđa i analiza, kao i sintetičkih jedinjenja, u izučavanju i manipulaciji bioloških sistema. Hemijska biologija koristi hemijske principe u istraživanju bioloških sistema i razvoju novih funkcija tih sistema. Hemijsko biološka istraživanja često imaju više srodnosti sa citologijom nego sa biohemijom. Biohemija izučava hemiju biomolekula i regulaciju biohemijskih puteva u ćelijama i tkivima, npr. cAMP ili cGMP, dok je fokus hemijske biologije na biološkoj primeni novih hemijskih jedinjenja.

## Povezano

* Hemijska genetika
* Hemogenomika

## Reference

## Literatura

* Andrew D. Miller, Julian Tanner (2008). *Essentials of Chemical Biology: Structure and Dynamics of Biological Macromolecules* (1st izd.). Wiley. ISBN 0470845317.
* Herbert Waldmann, Petra Janning (2009). *Chemical Biology* (1st izd.). Wiley-VCH. ISBN 3527323309.

* Dertinger S. K. W., Chiu D. T., Jeon N. L., Whitesides G. M. (2001). „Generation of gradients having complex shapes using microfluidic networks”. *Analytical Chemistry* **73**: 1240–1246.
* Greif D, Pobigaylo N, Frage B, Becker A, Regtmeier J, Anselmetti D (2010). „Space- and time-resolved protein dynamics in single bacterial cells observed on a chip”. *Journal of Biotechnology* **149** (4): 280–288. DOI:10.1016/j.jbiotec.2010.06.003. PMID 20599571.
* Li L, Ismagilov RF (2010). „Protein crystallization using microfluidic technologies based on valves, droplets, and SlipChip”. *Annu Rev Biophys* **39**: 139–58. DOI:10.1146/annurev.biophys.050708.133630. PMID 20192773.
* Lucchetta EM, Lee JH, Fu LA, Patel NH, Ismagilov RF (2005). „Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics”. *Nature* **434** (7037): 1134–1138. Bibcode 2005Natur.434.1134L. DOI:10.1038/nature03509. PMC 2656922. PMID 15858575.
* Melin J, Quake SR (2007). „Microfluidic large-scale integration: The evolution of design rules for biological automation”. *Annual Review of Biophysics and Biomolecular Structure* **36**: 213–231. DOI:10.1146/annurev.biophys.36.040306.132646. PMID 17269901.
* Shen F, Du WB, Kreutz JE, Fok A, Ismagilov RF (2010). „Digital PCR on a SlipChip”. *Lab on a Chip* **10** (20): 2666–2672. DOI:10.1039/c004521g. PMC 2948063. PMID 20596567.
* Song H., Chen D. L., Ismagilov R. F. (2006). „Reactions in droplets in microflulidic channels”. *Angewandte Chemie-International Edition* **45**: 7336–7356.
* Spiller DG, Wood CD, Rand DA, White MRH (2010). „Measurement of single-cell dynamics”. *Nature* **465** (7299): 736–745. Bibcode 2010Natur.465..736S. DOI:10.1038/nature09232. PMID 20535203.
* Tice JD, Song H, Lyon AD, Ismagilov RF (2003). „Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers”. *Langmuir* **19** (22): 9127–9133. DOI:10.1021/la030090w.
* Vincent ME, Liu WS, Haney EB, Ismagilov RF (2010). „Microfluidic stochastic confinement enhances analysis of rare cells by isolating cells and creating high density environments for control of diffusible signals”. *Chemical Society Reviews* **39** (3): 974–984. DOI:10.1039/b917851a. PMC 2829723. PMID 20179819.
* Weibel DB, Whitesides GM (2006). „Applications of microfluidics in chemical biology”. *Current Opinion in Chemical Biology* **10** (6): 584–591. DOI:10.1016/j.cbpa.2006.10.016. PMID 17056296.
* Whitesides GM (2006). „The origins and the future of microfluidics”. *Nature* **442** (7101): 368–373. Bibcode 2006Natur.442..368W. DOI:10.1038/nature05058. PMID 16871203.
* Young EWK, Beebe DJ (2010). „Fundamentals of microfluidic cell culture in controlled microenvironments”. *Chemical Society Reviews* **39** (3): 1036–1048. DOI:10.1039/b909900j. PMC 2967183. PMID 20179823.

## Vanjske veze

* Chemical Biology - BioChemWeb.org Arhivirano 2013-08-12 na Wayback Machine-u
* Chemical Biology Doctoral Training Centre, Imperial College London
* International Chemical Biology Society