Rikunarita-ORG/Wikinium huggingface dataset:
# Quinine

quinine

type of chemical entity| Subclass of | Cinchonan-9-ol, 6'-methoxy-, (8alpha,9R)-, quinidine, epiquinine  |
| Get use | Medication  |
| Stylized name | quiNINE  |
| Stereoisomer of | epiquinidine  |
| Chemical formula | C₂₀H₂₄N₂O₂  |
| Canonical SMILES | COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O  |
| Isomeric SMILES | COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O  |
| Active ingredient in | Qualaquin  |
| Medical condition treated | Babesiosis, muscle cramp, Plasmodium falciparum malaria  |
| Physically dey interact plus | Potassium voltage-gated channel subfamily B member 2, Solute carrier family 29 member 4, taste receptor type 2  |
| Legal status (medicine) | boxed warning  |
| Pregnancy category | Australian pregnancy category D, US pregnancy category C  |
| LiverTox likelihood score | LiverTox toxicity likelihood category B  |
| Natural product of taxon | Cinchona  |
| Get characteristic | bitterness  |

**Quinine** be a medication dem use to treat malaria den babesiosis. Dis dey include de treatment of malaria secof *Plasmodium falciparum* wey be resistant to chloroquine wen artesunate no be available. While dem sam times use am give nocturnal leg cramps, quinine no be recommended for dis purpose secof de risk of serious side effects. Dem fi be take am by mouth anaa intravenously. Malaria resistance to quinine dey occur insyd certain areas of de world. Quinine sanso be used as an ingredient insyd tonic water den oda beverages to impart a bitter taste.

Common side effects dey include headache, ringing insyd de ears, vision issues, den sweating. More severe side effects dey include deafness, low blood platelets, den an irregular heartbeat. Ein use fi make one more prone to sunburn. While e be unclear if ein use during pregnancy dey carry potential for fetal harm, treating malaria during pregnancy .plus quinine wen appropriate still be recommended. Quinine be an alkaloid, a naturally occurring chemical compound. E dey possess a C9H7N quinoline functional group (pyridine dem fuse to benzene).

Quinine be first isolated insyd 1820 from de bark of a cinchona tree, wich be native to Peru, den ein molecular formula be determined by Adolph Strecker insyd 1854. De class of chemical compounds to wich e dey belong be thus called de cinchona alkaloids. Na bark extracts be used to treat malaria since at least 1632 wey e be introduced to Spain as early as 1636 by Jesuit missionaries wey dey return from de New World. E dey on de World Health Organization's List of Essential Medicines. Treatment of malaria plus quinine dey mark de first known use of a chemical compound to treat an infectious disease.

* Quinine at the Drug Information Portal - U.S. National Library of Medicine
* Quinine at the International Programme on Chemical Safety
* "Quinine". *Resource Center*. Chemwatch.