# Etoposido

| Etoposido |
| --- |
|  |
| Formula kimikoa | C29H32O13 |
| SMILES kanonikoa | 2D eredua |
| SMILES isomerikoa | C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O |
| MolView | 3D eredua |
| Mota | [[(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] (en)  eta [[(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] (en)  |
| Estereoisomeroa | [[(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one]] (en)  |
| Masa molekularra | 588,184 Da |
| Erabilera |
| Konposatu aktiboa | Toposar (en)  eta Etopophos (en)  |
| Tratatzen du | Neuroblastoma, testicular cancer (en) , garuneko minbizi, mikosi fungoide, trophoblastic neoplasm (en) , Ewingen sarkoma, histiozitosi, lung benign neoplasm (en) , prostatako minbizi, umetokiko minbizi, Kaposiren sarkoma, leuzemia mieloide akutu, errabdomiosarkoma, maxkuriko minbizi, linfoma, germ cell cancer (en) , B-cell lymphoma (en) , ez-Hodgkin linfoma, testicular malignant germ cell cancer (en) , Hezur sarkoma, neuroblastoma, susceptibility to (en) , diffuse large B-cell lymphoma (en) , testicular cancer (en)  eta lung small cell carcinoma (en)  |
| Interakzioak | ziklosporina |
| Elkarrekintza | DNA topoisomerase II alpha (en)  |
| Hartzeko bidea | intravenous infusion and defusion (en)  eta oral administration (en)  |
| Haurdunaldia | Australian pregnancy category D (en)  eta US pregnancy category D (en)  |
| Rola | DNA polymerase inhibitors (en) , topoisomerase inhibitor (en) , phytogenic antineoplastic agents (en) , topoisomerase II inhibitor (en) , developmental toxicant (en) , kantzerigeno eta farmako esentzial |
| Identifikatzaileak |
| InChlKey | VJJPUSNTGOMMGY-MRVIYFEKSA-N |
| CAS zenbakia | 33419-42-0 |
| ChemSpider | 33510 |
| PubChem | 36462 |
| Gmelin | 4911 |
| ChEMBL | CHEMBL44657 |
| EC zenbakia | 251-509-1 |
| ECHA | 100.046.812 |
| MeSH | D005047 |
| RxNorm | 4179 |
| Human Metabolome Database | HMDB0014911 |
| UNII | 6PLQ3CP4P3 |
| NDF-RT | N0000146478 |
| KEGG | C01576 eta D00125 |
| PDB Ligand | EVP |

Ohar medikoa **Oharra: Wikipediak ez du mediku aholkurik ematen**. *Tratamendua behar duzula uste baduzu, jo ezazu sendagilearengana.*

**Etoposidoa**, **VP-16** bezala ere ezaguna, podofilina erdisintetiko bat da, *Podophyllum* landaretik eratorria. Tumore-zelulen ugalketa inhibitzeko duen gaitasunagatik minbizi mota batzuk tratatzeko erabiltzen dute.

Banaketa azkarreko zelula osasuntsu batzuetan ere eragin dezake, hala nola odolaren, digestio-aparatuaren edo ilearen zeluletan, eta, beraz, albo-ondorio kaltegarriak ere sortzen ditu.

Etoposidoa 1983an merkaturatu zuten.

## Erreferentziak

## Kanpo estekak

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|  | Artikulu hau kimikari buruzko **zirriborroa** da. Wikipedia lagun dezakezu edukia osatuz. |