# CD38

| CD38 |
| --- |
|  |
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| Strwythurau |
| --- |
| PDB | Human UniProt search: PDBe RCSB  |
|

| [dangos]Rhestr o ddynodwyr PDB |
| --- |
| 4TMF, 1YH3, 1ZVM, 2EF1, 2HCT, 2I65, 2I66, 2I67, 2O3Q, 2O3R, 2O3S, 2O3T, 2O3U, 2PGJ, 2PGL, 3DZF, 3DZG, 3DZH, 3DZI, 3DZJ, 3DZK, 3F6Y, 3I9M, 3I9N, 3OFS, 3RAJ, 3ROK, 3ROM, 3ROP, 3ROQ, 3U4H, 3U4I, 4CMH, 4F45, 4F46, 4OGW, 4XJS, 4XJT, 5F1K, 5F1O, 5F21 |

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| Dynodwyr |
| Cyfenwau | CD38, ADPRC1, ADPRC 1, CD38 molecule |
| Dynodwyr allanol | OMIM: 107270 HomoloGene: 1345 GeneCards: CD38  |
| EC number | 2.4.99.20 |
|

| [cuddio]Patrwm RNA pattern |
| --- |
|  |
| Rhagor o gyfeiriadau  |

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| [dangos]Ontoleg y genyn |
| --- |
| Gweithrediad moleciwlaidd | • transferase activity • hydrolase activity, acting on glycosyl bonds • NAD(P)+ nucleosidase activity • hydrolase activity • NAD+ nucleotidase, cyclic ADP-ribose generating • NAD+ nucleosidase activity • phosphorus-oxygen lyase activity • identical protein binding  |
| Cydrannau o'r gell | • integral component of membrane • bilen • intracellular membrane-bounded organelle • cell surface • extracellular exosome • cnewyllyn cell • cellbilen • basolateral plasma membrane • secretory granule membrane  |
| Prosesau biolegol | • B cell receptor signaling pathway • response to cytokine • response to estradiol • response to interleukin-1 • response to hypoxia • response to retinoic acid • positive regulation of cytosolic calcium ion concentration • response to progesterone • female pregnancy • negative regulation of apoptotic process • response to hydroperoxide • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • positive regulation of cell growth • positive regulation of B cell proliferation • positive regulation of vasoconstriction • long-term depression • apoptotic signaling pathway • response to hormone • GO:0045996 negative regulation of transcription, DNA-templated • GO:0072468 signal transduction • positive regulation of insulin secretion • negative regulation of bone resorption • NAD metabolic process • positive regulation of cell population proliferation • negative regulation of neuron projection development • artery smooth muscle contraction  |
| Sources:Amigo / QuickGO |

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| Orthologau |
| Species | **Bod dynol** | **Llygoden** |
| Entrez |

|  |
| --- |
| 952 |

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|  |
| --- |
| n/a |

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| Ensembl |

|  |
| --- |
| ENSG00000004468 |

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|  |
| --- |
| n/a |

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| UniProt |

|  |
| --- |
| P28907 |

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|  |
| --- |
| n/a |

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| RefSeq (mRNA) |

|  |
| --- |
| NM\_001775 |

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|  |
| --- |
| n/a |

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| RefSeq (protein) |

|  |
| --- |
| NP\_001766 |

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|  |
| --- |
| n/a |

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| Lleoliad (UCSC) | n/a | n/a |
| PubMed search |  | n/a |
| Wicidata |
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|  |  |
| --- | --- |
| Gweld/Golygu Bod dynol |  |

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Protein sy'n cael ei godio yn y corff dynol gan y genyn *CD38* yw **CD38** a elwir hefyd yn *CD38 molecule* (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4p15.32.

## Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CD38.

* ADPRC1
* ADPRC\*1

## Llyfryddiaeth

* "*CD38 enhances the proliferation and inhibits the apoptosis of cervical cancer cells by affecting the mitochondria functions.* ". *Mol Carcinog*. 2017. PMID 28544069.
* "*ADP ribosyl-cyclases (CD38/CD157), social skills and friendship.* ". *Psychoneuroendocrinology*. 2017. PMID 28212520.
* "*Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome.* ". *Cell Rep*. 2016. PMID 27926864.
* "*CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma.* ". *Blood*. 2016. PMID 27307294.
* "*CD38 Expression in a Subset of Memory T Cells Is Independent of Cell Cycling as a Correlate of HIV Disease Progression.*". *Dis Markers*. 2016. PMID 27064238.

## Cyfeiriadau