Chemogenomics | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-03-26

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Chemogenomics


00:01:30 1 Strategy
00:03:07 1.1 Forward chemogenomics
00:03:58 1.2 Reverse chemogenomics
00:04:48 2 Applications
00:04:57 2.1 Determining mode of action
00:06:53 2.2 Identifying new drug targets
00:07:48 2.3 Identifying genes in biological pathway
00:09:07 3 See also



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SUMMARY
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Chemogenomics, or chemical genomics, is the systematic screening of targeted chemical libraries of small molecules against individual drug target families (e.g., GPCRs, nuclear receptors, kinases, proteases, etc.) with the ultimate goal of identification of novel drugs and drug targets.  Typically some members of a target library have been well characterized where both the function has been determined and compounds that modulate the function of those targets (ligands in the case of receptors, inhibitors of enzymes, or blockers of ion channels)  have been identified. Other members of the target family may have unknown function with no known ligands and hence are classified as orphan receptors. By identifying screening hits that modulate the activity of the less well characterized members of the target family, the function of these novel targets can be elucidated.  Furthermore, the hits for these targets can be used as a starting point for drug discovery. The completion of the human genome project has provided an abundance of potential targets for therapeutic intervention.  Chemogenomics strives to study the intersection of all possible drugs on all of these potential targets.A common method to construct a targeted chemical library is to include known ligands of at least one and preferably several members of the target family. Since a portion of ligands that were designed and synthesized to bind to one family member will also bind to additional family members, the compounds contained in a targeted chemical library should collectively bind to a high percentage of the target family.