Dysregulation of circRNA-miRNA Networks During Lytic Induction of KSHV
Channel: ISCB-SC Webinars
Date: 2021-02-25

Dysregulation of miRNA networks is one mechanism by which viruses dysregulate host functioning to promote their replication and propagation. Owing to their stability, ubiquity and capacity to bind miRNAs, circRNAs are emerging as key regulators of such networks. We aim to elucidate the dysregulation of circRNA-miRNA networks by the oncogenic Kaposi’s Sarcoma-associated Herpesvirus, during it’s reactivation from latent to lytic life-cycles. RNAs were profiled and differentially expressed biotypes determined. A network was constructed from these based on various sources of miRNA-target evidence and various topological measures were computed and community detection performed. This revealed a dense core comprising 3 miRNAs, 4 circRNAs and predominantly viral transcripts. These results suggest a role of this core in regulating viral and thus cellular activity during lytic induction.