PROTON PUMP INHIBITORS, BASIC USE OF MEDICINE, EXAMPLES, MECHANISM, DOSE, SIDE-EFFECTS, PHARMACOLOGY
Channel: PHARMAROCKS THE WAY OF SUCCESS
Date: 2021-01-26

PROTON PUMP INHIBITORS, BASIC USE OF MEDICINE, EXAMPLES, MECHANISM, DOSE, SIDE-EFFECTS, PHARMACOLOGY

PROTON PUMP INHIBITORS
Proton-pump inhibitors are members of a class of medications whose main action is a profound and prolonged reduction of stomach acid production
PPIs work by inhibiting certain stomach cells from "pumping" acid into stomach.

PROTON PUMP INHIBITORS
When taken 30 to 60 minutes before a meal, PPIs can prevent or reduce heartburn. 
However, they do not work as well when taken on demand as they do when taken over a period of time.
To quantify and compare the effect on daytime gastric acidity of omeprazole 20 mg or lansoprazole 30 mg daily taken 15 min before breakfast, with that of the same drug taken without a meal.

PROTON PUMP INHIBITORS EXAMPLES
Available over-the-counter 
(without a prescription)
Omeprazole,
Esomeprazole, 
Lansoprazole,
Zegerid (omeprazole with sodium bicarbonate), also available over-the-counter (without a prescription)

PROTON PUMP INHIBITORS DOSES

PROTON PUMP INHIBITORS EXAMPLES
PRESCIPTION DRUGS (Rx ONLY)
Rabeprazole,
Pantoprazole,
Dexlansoprazole,

How is acid secreted in the stomach?
Acid is secreted by parietal cells in the proximal two thirds (body) of the stomach. 
Gastric acid aids digestion by creating the optimal pH for pepsin and gastric lipase and by stimulating pancreatic bicarbonate secretion.

PROTON PUMP INHIBITORS MECHANISM
They inhibit gastric acid secretion by selectively and non‐competitively inactivating & block the H+, K+ ATPase molecules of the parietal cell, but possibly only those that are actively secreting acid. 
This might imply that stimulation of acid secretion by a meal is necessary for optimal inhibition of gastric secretion.

USES OF PROTON PUMP INHIBITORS 
Relieve symptoms of acid reflux, 
Gastroesophageal reflux disease (GERD). 
Zollinger-ellison syndrome
Treat a duodenal ulcer 
stomach (gastric) ulcer.
Peptic ulcer
Treat damage to the lower esophagus caused by acid reflux.
To treat condition of acidity

PROTON PUMP INHIBITORS SIDE EFFECTS
Numerous side effects of proton pump inhibitors (PPIs) have been proposed, including 
Increased risk of gastric neoplasia, 
Kidney disease
Dementia (loss of memory, language, problem-solving and other thinking abilitie)
Liver disease
Fractures.

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