Gastrointestinal stromal tumor | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-12-30

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Gastrointestinal_stromal_tumor


00:00:44 1 Classification
00:03:08 2 Signs and symptoms
00:03:41 3 Pathophysiology
00:04:38 3.1 Genetics
00:05:40 3.2 c-KIT mutations
00:08:16 3.3 PDGFRA mutations
00:08:50 3.4 Wild-type tumors
00:09:38 4 Diagnosis
00:11:38 4.1 Imaging
00:14:41 4.1.1 Small GISTs
00:15:43 4.1.2 Large GISTs
00:17:24 4.1.3 Features of malignancy
00:18:25 5 Management
00:21:17 6 Epidemiology



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SUMMARY
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs arise in the smooth muscle pacemaker interstitial cell of Cajal, or similar cells. They are defined as tumors whose behavior is driven by mutations in the KIT gene (85%),  PDGFRA gene (10%), or BRAF kinase (rare). 95% of GISTs  stain positively for KIT (CD117).  Most (66%) occur in the stomach and gastric GISTs have a lower malignant potential than tumors found elsewhere in the GI tract.