NMN Treats Breast Cancer? New Study Results Released
Channel: Lifespan News
Date: 2023-02-15

NAD is important because it plays a role in regulating things like energy production and DNA repair. Basically, having more of it is generally a good thing. Its levels decline with age, and supplementation through precursors like NMN and NR has shown benefits. But, NAD is a double-edged sword. It can also be used as fuel by some cancer cell types.

You can learn more about the potential legal issues going on with NMN and the FDA in this episode of Lifespan News - https://youtu.be/mAQCY71MdZw

Researchers studied the effects of NAD on triple-negative breast cancer, or TNBC which is notoriously hard to treat. Cells of TNBC lack the three common receptors that are usually found on the surfaces of breast cancer cells. Without these receptors drugs won’t latch on so it’s difficult to target the cells with treatments. But this study showed that continuous use of NMN significantly impeded tumor growth and metastasis in mice, with similar results on cells taken from a human cancer patient.

The researchers first did a study in the laboratory (in vitro) to see what would happen when they added NMN to the cells. They discovered NMN increased levels of NAD in the cells really quickly. 

While NMN didn't affect the growth of the cancer cells, it did slow down their ability to spread and invade other cells. So how does NMN do this? Well, they sequenced the RNA of the tumor cells and found that NMN activated certain genes that are involved in regulating aging and the body's antioxidant system. Specifically one of the most important antioxidants we produce, glutathione.

But that's not all! The researchers also looked at the levels of a protein called SIRT1 and turns out TNBC was associated with lower levels of SIRT1 and that TNBC patients with higher levels of SIRT1 tended to have better survival rates. And when they tested resveratrol, they found that it decreased the spread of TNBC cells but again did not affect their growth.

The role that resveratrol plays in SIRT1 activation has been a point of contention in the longevity community, with pioneers like Dr. David Sinclair making some strong statements and others pushing back. This study does seem to support the idea that resveratrol could activate SIRT1, but for more on this controversy, check out this Lifespan News episode from Ryan O’Shea - https://youtu.be/xOHHfTOOHQ8

Finally, the researchers looked at oxidative stress. Oxidative stress occurs when there are too many harmful free radicals in the body, and it's been linked to a number of health problems, including cancer. They found that both NMN and SIRT1 acted to decrease oxidative stress and that this might play a role in decreasing the spread of cancer.

What’s more, all this research also seems to be pointing towards SIRT1 and NMN having an impact on a specific protein, p66Shc. There’s more to learn, but this study does make it seem like raising NAD levels through NMN supplementation could prove useful in treating this stubborn subtype of breast cancer.

SOURCES AND FURTHER READING
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NMN Reduces Metastasis in Difficult Breast Cancer Model - https://www.lifespan.io/news/nmn-reduces-metastasis-in-difficult-breast-cancer-model/

NAD+ supplementation limits triple-negative breast cancer metastasis via SIRT1-P66Shc signaling - https://www.nature.com/articles/s41388-023-02592-y

NAD Metabolism in Cancer Therapeutics - https://pubmed.ncbi.nlm.nih.gov/30631755/

Investigational Drug Treatments for Triple-Negative Breast Cancer - https://www.mdpi.com/2075-4426/11/7/652

What is Nicotinamide Mononucleotide? A Summary of NMN - https://www.lifespan.io/topic/nmn/

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