EPOCH (chemotherapy) | Wikipedia audio article
Channel: wikipedia tts
Date: 06/06/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/EPOCH_(chemotherapy)


00:01:10 Dosing regimen



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SUMMARY
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EPOCH is an intensive chemotherapy regimen intended for treatment of aggressive non-Hodgkin's lymphoma.It is often combined with rituximab. In this case it is called R-EPOCH or EPOCH-R.
[R]-EPOCH regimen consists of: 

(R)ituximab: an anti-CD20 monoclonal antibody, which has the ability to kill B cells, be they normal or malignant;
(E)toposide: a topoisomerase inhibitor from the group of epipodofyllotoxins;
(P)rednisolone: a glucocorticoid hormone that can cause apoptosis and lysis of both normal and malignant lymphocytes;
(O)ncovin, also known as vincristine: a vinca alkaloid that binds to the protein tubulin, thereby preventing the formation of microtubules and mitosis;
(C)yclophosphamide: an alkylating antineoplastic agent;
(H)ydroxydaunorubicin, also known as doxorubicin: an anthracycline antibiotic that is able to intercalate DNA, damaging it and preventing the cell division.