T cell activation and functions,Tcell subsets |Cellular component|Immunology|First Aid Lectures|Lec8
Channel: Dr. Jamil Lectures
Date: 2022-03-26

In this lecture we will discuss about  T cell activation and functions,t cell subsets,Th1,Th2,Th17,Treg.


https://youtu.be/88_Jf2RGlqM
https://youtu.be/FmzD6RdFFZs
https://youtu.be/aP06bUvyqCA

Instagram Account     dr_jamil56

T cell Activation
Macrophages engulfs antigen,process it and express it to t cells via MHC 1  or MHC 2.Exogenous antigen is present to CD 4 cells via MHC 2 while endogenous antigen present to CD8 T cells via MHC 1.
2nd signal for Ch4 TH2 is B7 from Macrophage and CD28 from TH2.T helper cells activates and produces cytokines that helps in killig of pathogens.
T cell functions
Cell mediated immunity is bt t cells.CD4 th1 produce cytokines for granuloma formation while CD8+ cells directly kills pathogens via cytotoxicity killing.delayed cell mediated hypersensitivity (type 4) is by t cells.and acute and chronic cellular organ rejection is also by t cells.
TH2 kills pathogens with the help of B cells( humoral immunity). th17 cells secretes IL17 for phagocytosis and neutrophilic inflammation,Treg prevents autoimmunity by maintaining tolerance to self antigens.


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