NHGRI DIR Seminar Series - John Greally
Channel: National Human Genome Research Institute
Date: 2023-04-26

Full Title: Variation in the non-coding genome and human phenotypes 

John M. Greally, Ph.D., D.Med., FACMG, is a professor of genetics and pediatrics at Albert Einstein College of Medicine and an attending physician at Montefiore Medical Center. In this presentation, Dr. Greally talks about the research in his lab, which is based on understanding models of genetic susceptibility to human disease, especially those affecting children. His lab focuses on understanding phenotypes through genetic or environmental influences that change the innate properties of a canonical cell type, or perturbations that alter cell lineage choices during differentiation. As researchers in the field of somatic cellular genomics, the lab studies the normal physiology of transcriptional regulation in mammalian cells as well as mosaic somatic mutations. His lab researches the effects of environmental and genetic influences on stem cell differentiation, with a focus on liver and blood diseases. They also focus on stem cell systems to understand mechanisms of cellular memory and reveal the functional variants in the non-coding majority of the human genome.

About the National Human Genome Research Institute (NHGRI) Division of Intramural Research (DIR) Seminar Series: The NHGRI DIR Seminar Series sponsors a monthly series of talks by intramural and special guest speakers celebrating genetics and genomics research. Speakers are selected by NHGRI intramural faculty and trainees and cover research topics of interest to a wide audience.

Relevant Links: 
DIR Seminar Series: https://www.genome.gov/dir/seminars
John Greally: https://www.einsteinmed.edu/faculty/4156/john-greally/
Center for Epigenomics at the Albert Einstein College of Medicine: https://www.einsteinmed.edu/centers/epigenomics/
GenomeDiver: https://genomediver.org/
The New York Center for Rare Diseases: