ENGS101P Cell Phenotype Recognition
Channel: Yixuan Cui
Date: 2016-10-24

UCL ENGS101P Engineering Challenges - Individual Video


Cell Phenotype Recognition - Vision and Imaging Science by Yixuan Cui


Script:
Cell phenotype recognition is a machine-based process analyzing phenotypes of different cells and differentiating them from each other.  This video is going to help you better understand the concept of cell phenotype recognition, how it works and also the reasons behind the development of this technology.

So, what is phenotype? Phenotype is the observable characteristics of an organism. For example, its appearance, biochemical properties and even its behavior. An organism’s phenotype can be influenced not only by its genes, but it’s living environment as well.

Cell phenotype recognition can be used for high throughput experiments and analyzing cells’ biological principles. However, huge volume of image data is created as a result, which mean it’s not practical to manual analysis as it takes time. This leads to the development of machine-learning algorithms.

Let’s see how it works. The whole process goes from image acquisition to image segmentation, and then feature extraction, selection & reduction and lastly phenotype classification. Image acquisition is when you taking digital images using microscopy. The segmentation procedure is to provide detailed shape and boundary information of individual cells. When goes into cells’ features, the algorithm will automatically classify the cell by comparing the features extracted to the existing cell features from the dataset to remove any irrelevant information and finally, reach the best possible match. Congratulations!

Just a quick summary of what we’ve covered so far. Phenotype of an organism is its observable characteristics. Machine-based cell phenotype recognition gives a quicker and more accurate identification by comparing extracted cell features with the dataset.

I hope you can pick up something from this video. And thanks for watching!