Desire to Heal: Neurobiology of Trauma
Channel: Doc Snipes
Date: 2017-03-07

Desire to Heal: Neurobiology of Trauma Dr. Dawn Elise Snipes explores the impact of trauma on the HPA Axis and how it can develop into PTSD.  Did you know that many traumatic reactions are expected and not everyone who experiences a trauma develops PTSD.
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This was recorded as part of a live #webinar

~ Neurobiological abnormalities in PTSD overlap with features found in traumatic brain injury
~ The response of an individual to trauma depends not only on stressor characteristics, but also on factors specific to the individual.
~ Perception of stressor
~ Proximity to safe zones
~ Similarity to victim
~ Degree of helplessness
~ Prior traumatic experiences
~ Amount of stress in the preceding months
~ Current mental health or addiction issues
~ Availability of social support
Introduction
~ For the vast majority of the population, the psychological trauma is limited to an acute, transient disturbance.
~ The signs and symptoms of PTSD reflect a persistent, abnormal adaptation of neurobiological systems to the witnessed trauma.
What is the HPA Axis
~ Hypothalamic-Pituitary-Adrenal Axis AKA the Threat Response System
~ Controls reactions to stress and regulates many body processes, including digestion, the immune system, mood and emotions, sexuality, and energy storage and expenditure
~ The ultimate result of the HPA axis activation is to increase levels of cortisol in the blood during times of stress.
~ Cortisol's main role is in releasing glucose into the bloodstream in order to facilitate the “flight or fight” response. It also suppresses and modulates the immune system, digestive system and reproductive system.
HPA-Axis Dysfunction
~ The body reduces its HPA axis activation when it appears that further fight/flight may not be beneficial. (Hypocortisolism)
~ Hypocortisolism seen in stress-related disorders such as CFS, burnout and PTSD is actually a protective mechanism designed to conserve energy during threats that are beyond the organism's ability to cope.
~ Dysfunctional HPA axis activation will result in
~ Abnormal immune system activation
~ Increased inflammation and allergic reactions
~ IBS symptoms such as constipation and diarrhea,
~ Reduced tolerance to physical and mental stresses (including pain)
~ Altered levels of sex hormones

GPT

Here are 20 timestamps for the video titled "Physiology of Addiction and Mental Health Issues":

    00:00:00 – Introduction to the webinar on addiction and co-occurring disorders
    00:01:44 – Discussing neurotransmitters and their role
    00:02:51 – Overview of sex, thyroid, and stress hormones
    00:03:58 – Hormones and neurotransmitters interaction in the body
    00:05:04 – Physiology of emotion and motivation
    00:06:16 – Role of sleep in neurotransmitter regulation
    00:08:30 – Impact of stimulants and their effect on neurotransmitters
    00:10:16 – Discussion on inhibitory neurotransmitters
    00:11:51 – Role of serotonin in sleep and gastrointestinal function
    00:14:36 – Impact of serotonin imbalance on anxiety and aggression
    00:16:42 – Role of GABA in reducing anxiety and impulsiveness
    00:19:24 – Impact of hypoglycemia on GABA production
    00:21:09 – Importance of glucose for GABA formation
    00:24:31 – Role of glutamate in brain function and memory
    00:26:46 – Norepinephrine's role in attention and memory
    00:33:10 – Dopamine's link to motivation and pleasure
    00:42:16 – Impact of alcohol on serotonin and sleep regulation
    00:45:25 – Relationship between cortisol and appetite regulation
    00:50:04 – Impact of stress hormones on body functions
    00:52:08 – Conclusion and final remarks on physiological impacts