ICU Drips: All About Propofol for Sedation
Channel: Nurse Howie
Date: 2021-11-12

Welcome to Nurse Howie where we go over ICU and critical care drips. This one's a pretty popular one: Propofol. This video will show you why! 

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All About Propofol IV
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REMEMBER: all propofol patients Need to be INTUBATED! Unlike Precedex, propofol will kill your patient’s respiratory drive 🫁 . 

Many of us know about Propofol and its part in aiding the pop singer Michael Jackson's death. But its use since the 80s(?) gives much value to the ICU and the surgical patient population. It keeps patients asleep so they don't experience the painful parts of a procedure or hospitalization. 

WHAT IS IT?

Propofol is a potent intravenous sedative-hypnotic drug used to induce and maintain anesthesia for sedation in intensive care unit and sometimes operating rooms.

WHAT'S IN IT?

Emulsion containing soybean oil, glycerol, egg lecithin. In addition, either edetate disodium (EDTA) or sodium metabisulfite has been added as a preservative. So check your patients to see if they have

1. Egg or soybean allergies (sulphate may also cause reactions)
2. Have hyperlipidemia (most cardiac patients do), then see if it's uncontrolled. You can probably still give it, but stay on top of it by monitoring labs


WHAT DOES IT LOOK LIKE?

Like milk. All these lipids are what propofol binds to, not water. So this soybean oil, egg, and glycerol together looks like milk. And if you guessed that it is sticky, you are correct! 

That's why it's called "Milk of Amnesia." Well, I don't know anyone that calls it that. They just usually say propofol more than the brand name, Diprivan, or better they just shorten it to "prop". 

HOW LONG DOES IT TAKE TO LEAVE THE BODY (PHARMACOKINETICS)

Clearance of propofol is 1.5-2.2 l/min. It is rapidly conjugated to molecules glucoronide and sulfate (you don't need to know that. Just know that they are excreted by the kidneys as inactive compounds).

FOR THE FULL TRANSCRIPT GO TO:
www.NurseHowie.com
Direct link:
https://biochemsite.com/nursehowie/2021/11/12/youtube-all-about-propofol-icu-drips/

References

Marik, Paul. 2004. Propofol: Therapeutic Indications and Side-Effects. Bentham Science Publishers, Ltd.


PLUG: For those interested in more information, visit my website, www.nursehowie.com for greater detail where more meta-analysis and reviews are utilized in evaluating propofol as well as other ICU and nursing related treatments. I also have an online class I will be offering called the Nova Nurse in the near future. There you will learn everything you need to know for critical care! 

And finally, don't forget to like and subscribe. Check out my critical care drips playlist and for my next videos I will be delving into vasoactive medications such as dobutamine, dopamine, and milrinone. See you soon! Bye! 
For the full transcript, go to: www.NurseHowie.com