Artificial Sweeteners
Channel: C0nc0rdance
Date: 2011-07-29

Warning:  Long, science-heavy video.  No funny cats or guys getting hit in the nuts.

Artificial sweeteners, or as they are usually referred to in the literature "non-caloric" sweeteners or "high-intensity" sweeteners, address the problem of sugar calorie excess in our diet.  They've been demonstrated to support weight loss or maintenance, reduce cavities and can be part of a healthy lifestyle.

Much focus has been on 

CSPI report:  http://www.cspinet.org/reports/chemcuisine.htm
I disagree with CSPI on about 25% of their rankings, but I appreciate that they take a very conservative stance.

Citations:
Aspartame:
1.  Comp Funct Genomics. 2010. In vivo cytogenetic studies on aspartame.
2.  Drug Chem Toxicol. 2004 Aug;27(3):257-68.  Genotoxicity of aspartame.
3.  Am J Ind Med. 2010 Dec;53(12):1197-206.  Aspartame administered in feed, beginning prenatally through life span, induces cancers of the liver and lung in male Swiss mice.
4.  Toxicol In Vitro. 2011 Feb;25(1):286-93.  In vitro effect of aspartame in angiogenesis induction.

Sucralose:
5.  Regul Toxicol Pharmacol. 2009 Oct;55(1):1-5.  An overview of the safety of sucralose.
6.  Regul Toxicol Pharmacol. 2009 Oct;55(1):6-12. Expert panel report on a study of Splenda in male rats.
7.  Food Chem Toxicol. 2000;38 Suppl 2:S53-69.  Acute and subchronic toxicity of sucralose.
8.  Food Chem Toxicol. 2000;38 Suppl 2:S71-89.  A combined chronic toxicity/carcinogenicity study of sucralose in Sprague-Dawley rats.
9.  Food Chem Toxicol. 2000;38 Suppl 2:S91-7.  A carcinogenicity study of sucralose in the CD-1 mouse.

AceK:
10.  Horm Metab Res. 1987 Jun;19(6):233-8.  The effect of artificial sweetener on insulin secretion. 1. The effect of acesulfame K on insulin secretion in the rat (studies in vivo).
11.  Food Chem Toxicol. 1997 Dec;35(12):1177-9.  In vivo cytogenetic studies on mice exposed to acesulfame-K--a non-nutritive sweetener.

General reviews:
12.  Ann Oncol. 2004 Oct;15(10):1460-5.  Artificial sweeteners--do they bear a carcinogenic risk?
13.  Yale J Biol Med. 2010 Jun;83(2):101-8.  Gain weight by "going diet?" Artificial sweeteners and the neurobiology of sugar cravings
14.  Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 2:S12-7.  Effect of sucrose and sweeteners on appetite and energy intake.
15.  Am J Clin Nutr. 2009 Jan;89(1):1-14.  Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms.
16.  Physiol Behav. 2010 Apr 26;100(1):55-62.  High-intensity sweeteners and energy balance.
17.  Physiol Behav. 2009 Dec 7;98(5):618-24.  Effect of moderate intake of sweeteners on metabolic health in the rat.
18.  Food Addit Contam. 2006 Apr;23(4):327-38.  The intake of intense sweeteners - an update review.