Turning back the clock
Channel: Lifespan News
Date: 2021-02-15

What happens when scientists turn back the clock and make cells younger? Let's talk about Yamanaka factors and what they mean for longevity and aging research.

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SOURCES AND FURTHER READING
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Abad M, Mosteir L, Pantoja C, Cañamero M, Rayon T, Ors I, Graña O, Megias D, Domínguez O, Martínez D, Manzanares M, Ortega S, Serrano M. (2013) Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature. 502:340–345 https://doi.org/10.1038/nature12586

Horvath S. (2013) DNA methylation age of human tissues and cell types. Genome Biology 14, R115. https://doi.org/10.1186/gb-2013-14-10-r115

Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Aït-Hamou N, Leschik J, Pellestor F, Ramirez JM, De Vos J, Lehmann S, Lemaitre JM (2011) Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 25:2248–2253 https://doi.org/10.1101/gad.173922.111

Liu GH, Barkho BZ, Ruiz S, Diep D, Qu J, Y SL, Panopoulos AD, Suzuki K, Kurian L, Walsh C, Thompson J, Boue S, Fung HL, Sancho-Martinez I, Zhang K, Yates J, Belmonte JCI (2011) Recapitulation of premature aging with iPSCs from Hutchinson Gilford Progeria Syndrome. Nature. 472:221–225 https://doi.org/10.1038/nature09879

Ocampo A, Reddy P, Martinez-Redondo P, Platero-Luengo A, Hatanaka F, Hishida T, Li M, Lam D, Kurita M, Beyret E, Araoka T, Vazquez-Ferrer E, Donoso D, Roman JL, Xu J, Esteban CR, Nuñez G, Delicado EN, Campistol JM, Guillen I, Guillen P, Belmonte JCI  (2016) In vivo amelioration of age-associated hallmarks by partial reprogramming. Cell. 167:1719–1733.e12 https://doi.org/10.1016/j.cell.2016.11.052

Ohnishi K, Semi K, Yamamoto T, Shimizu M, Tanaka A, Mitsunaga K, Okita K, Osafune K, Arioka Y, Maeda T, Soejima H, Moriwaki H, Yamanaka S, Woltjen K, Yamada Y. (2014) Premature termination of reprogramming in vivo leads to cancer development through altered epigenetic regulation. Cell. 156:663–677. https://doi.org/10.1016/j.cell.2014.01.005

Polo JM, Anderssen E, Walsh Rm, Schwarz BA, Nefzger CM, Lim SM, Borkent M, Apostolou E, Alaei S, Cloutier J, Bar-Nur O, Cheloufi S, Stadtfeld M, Figueroa ME, Robinton D, Natesan S, Melnick A, Zhu J, Ramaswamy S, Hochedlinger K. (2012) A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells. Cell 151, 1617-1632. https://doi.org/10.1016/j.cell.2012.11.039

Takahashi K and Yamanaka S. (2006) Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell 126, 663-676. https://doi.org/10.1016/j.cell.2006.07.024

Yagi T, Kosakai A, Ito D, Okada Y, Akamatsu W, Nihei Y, Nabetani A, Ishikawa F, Arai Y, Hirose N, Okano H, Suzuki N. (2012) Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One. 7:1–7 https://doi.org/10.1371/journal.pone.0041572

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FOOTAGE, IMAGES, AND MUSIC CREDITS
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Stock photos from Shutterstock.com
Stock footage from MotionElements.com and  Videoblocks.com

Music: "Monkey races" by Eric Matyas

Thumbnail font: Cocogoose Pro Family by Zetafonts -http://www.zetafonts.com/collection/308

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#StemCells #longevity #rejuvenation #Yamanaka #Epigenetics #LifeExtension #MolecularBiology