RNA Modifications in Aging-Associated Cardiovascular Diseases | Aging-US
Channel: Aging (Aging-US)
Date: 2022-10-25

Aging (Aging-US) published this trending review in Volume 14, Issue 19, entitled, “RNA modifications in aging-associated cardiovascular diseases” by researchers from Fangshan Hospital Beijing University of Chinese Medicine, Beijing 102400, China; Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated with Beijing University of Chinese Medicine, Beijing 100700, China; Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA; College of Basic Medical and Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, Heilongjiang, China; Guang’an Men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China; Center for Transplantation Science, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
#aging  #openaccess  #cardiovasculardisease #heart  #research  #review   #rna #peerreview 

DOI - https://doi.org/10.18632/aging.204311

Corresponding authors - Guoping Li - gli21@mgh.harvard.edu , Shuwen Guo - guo1163@163.com , Hongcai Shang - shanghongcai@bucm.edu.cn 

ABSTRACT

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide that bears an enormous healthcare burden and aging is a major contributing factor to CVDs. Functional gene expression network during aging is regulated by mRNAs transcriptionally and by non-coding RNAs epi-transcriptionally. RNA modifications alter the stability and function of both mRNAs and non-coding RNAs and are involved in differentiation, development, and diseases. Here we review major chemical RNA modifications on mRNAs and non-coding RNAs, including N6-adenosine methylation, N1-adenosine methylation, 5-methylcytidine, pseudouridylation, 2′ -O-ribose-methylation, and N7-methylguanosine, in the aging process with an emphasis on cardiovascular aging. We also summarize the currently available methods to detect RNA modifications and the bioinformatic tools to study RNA modifications. More importantly, we discussed the specific implication of the RNA modifications on mRNAs and non-coding RNAs in the pathogenesis of aging-associated CVDs, including atherosclerosis, hypertension, coronary heart diseases, congestive heart failure, atrial fibrillation, peripheral artery disease, venous insufficiency, and stroke.

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Keywords - aging, RNA, RNA modification, cardiovascular disease,aging-related cardiovascular diseases, epitranscriptome

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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