A New Type of Protein Chemistry - NOS Bridges
Channel: Curiosity Lab
Date: 2022-05-02

A few weeks ago, I came along a blogpost on “In the Pipeline” about the discovery of NOS bridges in proteins. NOS bridges are covalent interactions between amino acids, linked by an oxygen atom, and have the potential to regulate a protein’s function and determine its three-dimensional shape. So I wanted to dig a bit deeper into what this discovery means for protein chemistry.

Derek Lowe’s blogpost: https://www.science.org/content/blog-post/so-proteins-do

00:00 Intro
00:52 Part I: the discovery
02:21 Part II: the chemistry
04:40 Part III: redox regulation
05:49 Part IV: the biological significance

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Main sources:
- Wensien et al., 2021, DOI: 10.1038/s41586-021-03513-3
- Rabe von Pappenheim et al., 2022, DOI: 10.1038/s41589-021-00966-5

Pictures and videos: (Licenses: https://creativecommons.org/licenses )
- Wild_type_Neisseria_gonorrhoeae_(29347475808): Oregon State       University, CC BY-SA 2.0 
- Neisseria_gonorrhoeae_Bacteria_(16221300454): NIAID, CC BY 2.0 
- High-Glucose-Mediated-Oxidative-Stress-Impairs-Cell-Migration-pone.0022865.s005: Lamers M, Almeida M, Vicente-Manzanares M, Horwitz A, Santos M, CC BY 2.5
- Mechanism-of-Cancer-Cell-Death-Induced-by-Depletion-of-an-Essential-Replication-Regulator-pone.0036372.s007: Ito S, Ishii A, Kakusho N, Taniyama C, Yamazaki S, Fukatsu R, Sakaue-Sawano A, Miyawaki A, Masai H, CC BY 2.5