Selectivity filter scanning of hHV1-Morgan et al.
Channel: Journal of General Physiology
Date: 2014-01-24

Extraordinary selectivity is crucial to all proton-conducting molecules, including the human voltage-gated proton channel (hHV1), because the proton concentration is more than a million times lower than that of other cations. Here we use "selectivity filter scanning" to elucidate the molecular requirements for proton-specific conduction in hHV1.