PhIP: The Three Strikes Breast Carcinogen
Channel: NutritionFacts.org
Date: 2013-01-18

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DESCRIPTION: The cooked meat carcinogen PhIP found in fried bacon, fish, and chicken may not only trigger cancer and promote tumor growth, but also increase its metastatic potential by increasing its invasiveness. The "difficult to avoid" line reminds me of the cop out in the Dead Meat Bacteria Endotoxemia (http://nutritionfacts.org/video/dead-meat-bacteria-endotoxemia/) video! This is the second of a four-part video series on heterocyclic amines, carcinogens such as PhIP that are formed when meat is cooked. In my last video Estrogenic Cooked Meat Carcinogens (http://nutritionfacts.org/video/estrogenic-cooked-meat-carcinogens/), I noted that in addition to being able to cause the initial DNA damage that may trigger breast cancer, these chemicals may act as potent estrogens, promoting the growth of such tumors as well.
 
The growth hormone IGF-1 may also promote tumor progression and invasion (see http://nutritionfacts.org/video/igf-1-as-one-stop-cancer-shop/). IGF-1 is released by our liver in response to animal protein consumption (why? See http://nutritionfacts.org/video/higher-quality-may-mean-higher-risk/)
 
On the other hand, broccoli and Indian gooseberries may have both anti-proliferative and anti-invasive properties: Lung Cancer Metastases and Broccoli (http://nutritionfacts.org/video/lung-cancer-metastases-and-broccoli/) and Amla Versus Cancer Cell Invasion (http://nutritionfacts.org/video/amla-versus-cancer-cell-invasion/).
 
In the next video Reducing Cancer Risk In Meateaters (http://nutritionfacts.org/video/reducing-cancer-risk-in-meateaters/), I'll note some ways for non-vegetarians to mediate their risk.

Have a question for Dr. Greger about this video? Leave it in the comment section at http://nutritionfacts.org/video/phip-the-three-strikes-breast-carcinogen/ and he'll try to answer it!

Image Credit: National Cancer Institute and U.S. Navy photo by Chief Warrant Officer 4 Seth Rossman via Wikimedia.

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