The stress of eating less
Channel: Lifespan News
Date: 2021-03-15

In this episode, we'll dive into the details of caloric restriction—what science knows about it, what effect it may have on healthspan and lifespan, and whether it's something worth trying.

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SOURCES AND FURTHER READING
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Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. (2009) Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. doi: 10.1126/science.1173635

Cooper TM, Mockett RJ, Sohal BH, Sohal RS, Orr WC. (2004) Effect of caloric restriction on life span of the housefly, Musca domestica. The FASEB Journal. doi: 10.1096/fj.03-1464fje

Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. (2014) Inactivation of Yeast Isw2 Chromatin Remodeling Enzyme Mimics Longevity Effect of Calorie Restriction via Induction of Genotoxic Stress Response. Cell. doi: 10.1016/j.cmet.2014.04.004

Forster MJ, Morris P, Solah RS. (2003) Genotype and age influence the effect of caloric intake on mortality in mice. The FASEB Journal. doi: 10.1096/fj.02-0533fje

Ke Z, Firsanov D, Spencer B, Seluanov A, Gorbunova V. Short-term calorie restriction enhances DNA repair by non-homologous end joining in mice. (2020) Aging and Mechanisms of Disease. doi: 10.1038/s41514-020-00047-2

Li Y, Daniel M, Tollefsbol TO. Epigenetic regulation of caloric restriction in Aging. (2011) BMC Medicine. doi: 10.1186/1741-7015-9-98

Maegawa S, Lu Y, Tahara T, Lee JT, Madzo J, Liang S, Jelinek J, Colman RJ, Issa JPJ. (2017) Caloric restriction delays age-related methylation drift. Nature Communications. doi: 10.1038/s41467-017-00607-3

Wei M, Fabrizio P, Hu J, Ge H, Chenc C, Li L, Longo VD. (2008) Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9. PLoS Genetics. doi: 10.1371/journal.pgen.0040013

https://www.nia.nih.gov/health/calorie-restriction-and-fasting-diets-what-do-we-know#should

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FOOTAGE, IMAGES, AND MUSIC CREDITS
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Stock images from Shutterstock

Music:
"Monkey Races" by Eric Matyas

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#calories #diet #fasting #Aging #LifeExtension #Biology #MolecularBiology