Spleen | Lymphoid structures | Immunology | First Aid Lectures | Lec.2 #drjamillectures
Channel: Dr. Jamil Lectures
Date: 2022-03-21

In this lecture we will discuss about spleen anatomy,its structure, Functioning.Splenic dysfunction,degradation of old Red blood cells,postsplenectomy blood findings,SHIN vaccination

https://youtu.be/gXGK6F_vDJQ
https://youtu.be/aP06bUvyqCA
Instagram account    dr_jamil56
SPLEEN
It is located in LUQ of abdomen, anterolateral to 
left kidney, protected by 9th-11th ribs. 
Sinusoids are long, vascular channels in red 
pulp  with fenestrated “barrel 
hoop” basement membrane.
 T cells are found in the periarteriolar 
lymphatic sheath (PALS) within the white 
pulp 
B cells are found in follicles within the 
white pulp. 
The marginal zone, in between the red pulp 
and white pulp, contains macrophages and 
specialized B cells, and is where antigenpresenting cells (APCs) capture blood-borne 
antigens for recognition by lymphocytes.
Splenic macrophages remove encapsulated 
bacteria.

Postsplenectomy blood findings:
 Howell-Jolly bodies (nuclear remnants)
 Target cells
 Thrombocytosis (loss of sequestration and 
removal)
 Lymphocytosis (loss of sequestration)
Vaccinate patients undergoing splenectomy or 
with splenic dysfunction against encapsulated 
organisms (pneumococci, Hib, meningococci).
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