Chemokine receptor | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-03-26

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Chemokine_receptor


00:01:30 1 Structural characteristics
00:03:20 2 Signal transduction
00:06:19 3 Selective pressures on Chemokine receptor 5 (CCR5)
00:10:14 4 Families



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SUMMARY
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Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been 20 distinct chemokine receptors discovered in humans.  Each has a rhodopsin-like 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism.  Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Four families of chemokine receptors differ in spacing of cysteine residues near N-terminal of the receptor.