Simulation #268 Dr. George Church - Synthetic Biology
Channel: Simulation
Date: 11/02/2019

Dr. George Church is a Geneticist, Molecular Engineer, and Chemist. He's been a Professor at Harvard & MIT for 33 years and runs the 100 person Church Lab. He's co-founded 22 companies, co-authored 500 papers, has 143 patent publications, and is the author of Regenesis.

http://arep.med.harvard.edu
https://en.wikipedia.org/wiki/George_M._Church
Regenesis ► http://bit.ly/SimRegenesis

SHOW NOTES 📝
0:00 Welcome, introduction, Dr. Church CV
1:30 Tweaking biology with a 30,000-foot view of history
3:01 "Point of awe" discussion; species extinction, DNA, and carbon sequestration
5:01 X-ray crystallography breakthrough conversation
7:18 Genome sequencing; founding early companies; data interoperability via blockchain
10:31 More on privacy and access controls; UBI mention; data silo and homomorphic encryption
13:12 CRISPR/Cas9 conversation; "eighth wave"; picking the best sequencing
15:53 TAL still in use; next-generation target is multiple sites at once; off-target and on-target, avoiding off-target
18:31 Use of computational biology in genetic engineering; inspiration of outliers
20:14 Vaccine and cognitive enhancement conversation
22:35 Neuroplasticity and neurodegeneration importance; MICrONS Project reference, reconstructing connectomes
25:38 Importance of knowledge preservation; "it takes a lifetime to get to a point of competence"; reversing the planned obsolescence of aging by actually staying younger
29:12 More on longevity and Dr. Church's work at the Wyss Institute; "atomically precise engineering at scale"
33:58 Managing a 100+ person lab and design conversation; failing fast, groups of three, interdisciplinary teams; importance of both co-mentorship and entrepreneurship
38:28 Keeping up with all the scientific developments
40:10 Information dissemination in the lab and educating the general public; pgED.org mention
42:53 Workflow design in the lab; alumni network, principle of patience
44:50 Simulation Q1: What is a core driving principle in your life?
46:30 Simulation Q2: Do you think we live in a simulation?
47:25 Simulation Q3: What is the most beautiful thing in the world?
48:26 Thanks and appreciation, closing comments

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