Atypical Parkinsonism by Dr Bimsara Senanayake
Channel: ASN Neurology
Date: 2021-06-19

Webinar 11 - 10 Pearls Series

Webinar series conducted by the Association of Sri Lankan Neurologists targeted at the Medical Officers, Medical Registrars, General Physicians, Family Physicians and Medical Students. A journey of 32 neurology topics, each with 10 pearls.

The eleventh lecture in the series, Atypical Parkinsonism is delivered by Dr Bimsara Senanayake who is a past president of the Association of Sri Lankan Neurologists. He is a Consultant Neurologist currently attached to the National Hospital of Sri Lanka.

10 Pearls of this lecture
1. Absence of tremor suggests atypical Parkinsonism
2. Patients with Parkinsonism who do not improve with levodopa are unlikely to have IPD
3. Parkinsonism with oculomotor dysfunction, postural instability, akinesia and cognitive decline suggest PSP
4. Radiological features of PSP are highly specific.
5. MSA is typically characterised by Parkinsonism, autonomic dysfunction, and a combination of cerebellar and pyramidal signs
6. The classical CBD phenotype consists of asymmetric Parkinsonism, cortical signs and possibly other signs such as dystonia and myoclonus, it is referred to as Corticobasal syndrome (CBS).
7. "Atypical" atypical Parkinsonism are new genetic conditions presenting with features of progressive supranuclear palsy, corticobasal degeneration, or multiple system atrophy
8. Diagnostic delays are common in atypical Parkinsonian syndromes in the absence of specific biomarkers.
9. Mental illness are common amongst patients with atypical Parkinsonism
10. tau-PET could potentially be useful for identifying early PSP

Thumbnail artwork - CC BY -SA 2.5 - Visanji, Naomi P., Patricia L. Brooks, Lili-Naz Hazrati, and Anthony E. Lang. “The Prion Hypothesis in Parkinson’s Disease: Braak to the Future.” Acta Neuropathologica Communications 1, no. 1 (May 8, 2013): 2. doi:10.1186/2051-5960-1-2. http://www.actaneurocomms.org/content/1/1/2

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