Respiratory burst and HMP shunt |Immunology | First Aid Lectures | lec19 #drjamillectures  #drjamil
Channel: Dr. Jamil Lectures
Date: 2022-04-05

In this lecture we will discuss about HMP shunt pathway in liver,neutrophils and RBCs and its functions.Our main focus will be on Respiratory burst,oxidative killing of pathogens or oxygen dependent killing of pathogens.


https://youtu.be/lxa87LWxG6I
https://youtu.be/q57n3SSCGwk
https://youtu.be/aP06bUvyqCA

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REspiratory Burst
Also called oxidative burst. Involves the activation of the phagocyte NADPH oxidase complex (eg, in neutrophils, monocytes), which utilizes O2 as a substrate. Plays an important role in the immune response  rapid release of reactive oxygen species (ROS). NADPH plays a role in both the creation and neutralization of ROS. Myeloperoxidase contains a blue-green, heme containing pigment that gives sputum its color.
Phagocytes of patients with CGD can utilize H2O2 generated by invading organisms and convert it to ROS. Patients are at  risk for infection by catalase ⊕ species (eg, S aureus, Aspergillus) capable of neutralizing their own H2O2, leaving phagocytes without ROS for fighting infections.
Pyocyanin of P aeruginosa generates ROS to kill competing pathogens. Oxidative burst also leads to K+ influx, which releases lysosomal enzymes. Lactoferrin is a protein found in secretory fluids and neutrophils that inhibits microbial growth via iron chelation.




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