Malabsorption | Wikipedia audio article
Channel: wikipedia tts
Date: 27/12/2018

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Malabsorption


00:01:53 1 Classification
00:02:21 2 Signs and symptoms
00:02:31 2.1 Gastrointestinal manifestations
00:04:59 2.2 Extraintestinal manifestations
00:06:38 2.3 Presentation
00:08:08 3 Causes
00:08:17 4 Pathophysiology
00:09:40 5 Diagnosis
00:10:34 5.1 Blood tests
00:11:46 5.2 Stool studies
00:12:19 5.3 Radiological studies
00:12:56 5.4 Interventional studies
00:13:39 5.5 Other investigations
00:14:13 5.6 Obsolete tests no longer used clinically
00:14:44 6 Management
00:16:06 7 See also



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SUMMARY
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Malabsorption is a state arising from abnormality in absorption of food nutrients across the gastrointestinal (GI) tract. Impairment can be of single or multiple nutrients depending on the abnormality. This may lead to malnutrition and a variety of anaemias.Normally the human gastrointestinal tract digests and absorbs dietary nutrients with remarkable efficiency. A typical Western diet ingested by an adult in one day includes approximately 100 g of fat, 400 g of carbohydrate, 100 g of protein, 2 L of fluid, and the required sodium, potassium, chloride, calcium, vitamins, and other elements. Salivary, gastric, intestinal, hepatic, and pancreatic secretions add an additional 7–8 L of protein-, lipid-, and electrolyte-containing fluid to intestinal contents. This massive load is reduced by the small and large intestines to less than 200 g of stool that contains less than 8 g of fat, 1–2 g of nitrogen, and less than 20 mmol each of Na+, K+, Cl–, HCO3–, Ca2+, or Mg2+.
If there is impairment of any of the many steps involved in the complex process of nutrient digestion and absorption, intestinal malabsorption may ensue. If the abnormality involves a single step in the absorptive process, as in primary lactase deficiency, or if the disease process is limited to the very proximal small intestine selective malabsorption of only a single nutrient may occur. However, generalized malabsorption of multiple dietary nutrients develops when the disease process is extensive, thus disturbing several digestive and absorptive processes, as occurs in coeliac disease with extensive involvement of the small intestine.