Could tretinoin weaken your skin? We explore the science
Channel: The Honest Channel
Date: 2023-01-01

In the first of a series of Dermal Debates, we put the minds of two specialists together to discuss some of the less explored evidence around tretinoin and what it means for our longer-term skin health.
#skinscience 

You can watch a follow-up to this debate in which we share the rarely-discussed data used to support the views expressed here https://youtu.be/jaxoh-JioQ4

Ivan Galanin trained in inflammation research with Sanofi, worked with the Mount Sinai School of Medicine and is now the founder of Adipeau skincare and the AESFIT channel @aeducator1  
You can find out more about his skincare at https://adipeau.com/

Dr Qian Xu is the founder of Skin Aesthetics and co-director of Redjuvenate Medical. You can follow her on Instagram at https://www.instagram.com/drqianxu/ to find out more and to get in touch for a holistic skin and anti-aging consultation. 

For a response with supporting evidence to the critique of this debate on the Dr Dray channel see the pinned comment below.

The studies referred to in the discussion relating to collagen synthesis and dermal thickness follow. 

Olsen E et al, Tretinoin emollient cream for photodamaged skin: Results of 48-week,
multicenter, double-blind studies, J Am Acad Dermatol 1997; 37:217-26.
Griffiths CEM et al, Restoration of collagen formation in photodamaged human skin by
tretinoin (retinoic acid). N Engl J Med 1993;329. 530-5
Kang S et al, “Long-Term Efficacy and Safety of Tretinoin Emollient Cream 0.05% in the
Treatment of Photodamaged Facial Skin”, Am J Clin Dermatol 2005; 6 (4): 245-253. 
Bhawan J, Histologic Evaluation of the Long Term Effects of Tretinoin on Photodamaged
Skin, Journal of Dermatological Science 11 (1996); 177-182. 

CHAPTERS
00:00 Intro
01:40 Dr Qian's take on tretinoin
04:38 Ivan on dermal changes
07:50 Dr Qian on why strength and duration matters
10:08 What the clinical trials linked to FDA approval say
14:50 Clare on the decades of happy patients
16:07 Is there a different way to use retin A/ tretinoin?
17:08 Dr Qian's protocol
23:26 Could retinoic acid affect fat?
25:40 Agreement!

Disclaimer: This video and all content on this channel is for informational purposes only and is not intended as medical advice and should not be treated as a substitute for medical advice.

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Edited by David at https://www.redfacilities.com