The Gut Brain Axis And Associated Disorders - With John Damianos MD
Channel: Daniel Rosehill
Date: 2022-08-23

John Damianos MD is an internal medicine resident at Yale and a frequent Tweeter on all matters related to gastrointestinal health, the gut-brain axis, and the microbiome.

I invited him to come on this YouTube channel in order to share some of his knowledge about these mysterious conditions and the advances that medical science has recently taken in furthering our understanding of them. 

== Covered in this conversation: ==

(Timestamps next section)

- The role of the microbiome in regulating the gut brain axis and the two way feedback process between our central and enteric nervous systems.
- Why doctors commonly favor older tricyclic antidepressants ("neuromodulators") over more modern drugs such as SSRIs and SNRIs
- What the drug pipeline and treatment horizon looks like for these conditions
- The Rome Foundation's decision to move away from the terminology 'functional' when describing these disorders
- "PTSD of the gut" - how physical and mental stressors can create lasting dysfunction and GI syndromes. 

== Links from Dr. Damianos ==

The 'placebo cancer' study mentioned:
https://www.sciencedirect.com/science/article/pii/0002934351902197

Early life stress and visceral hypersensitivity:
https://onlinelibrary.wiley.com/doi/full/10.1111/nmo.13170?casa_token=rWMilpqPcHIAAAAA%3Ac9u0NFo7xbsgDO4t1-X2ONWnvYHImo-pB6h5gvHfcld9DxUwuP145sNN9xXXETJwxHZ3-OX5arWGyEA

Development of the enteric nervous system:

https://www.nature.com/articles/nrgastro.2012.32
https://www.nature.com/articles/pr200196

Efficacy of CBS in IBS:

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01188-6

== Recommended watching = =

https://www.youtube.com/watch?v=YwDMmSwUOOU&ab_channel=DannyOrchard

== Terminology used:== 

DGBI: Disorders of the gut-brain interaction. 

Hopefully some good information here for patients and even pracitioners involved in treating these common conditions. 

== More about Dr. Damianos and his research interests ==

https://medicine.yale.edu/profile/john_damianos/

https://twitter.com/john_damianosMD

== Timestamps and chapters ==

Intro - 00:00
What is the gut brain axis? - 01:24
Can residual pain syndromes be distinguished from current 'insults' by symptoms? - 05:54
]
The role of specialised testing for rare cases - 07:00
Is GERD overdiagnosed and are more obscure gut brain conditions too often missed? - 08:32
The microbiome can affect the gut brain axis. Does it work the other way too? - 10:14
Supporting evidence for cognitive causes for physical disorders and microbiome changes - 14:30
What's the connection between functional dyspepsia and alterations to the bile acid pool? - 16:20
Why are older antidepressants preferred over SSRIs and SNRIs for treating functional dyspepsia and other diseases of the gut brain axis? - 18:40
Different neuromodulators' different receptor profiles and the disorders of the gut brain axis that they are typically used to treat - 20:32
John's thoughts on future treatments for FD and other disorders - 27:10
Where to follow Dr Damianos for more of his thinking and knowledge-sharing - 30:30
--

By: Daniel Rosehill 

== Contact Information ===

For latest contact information: 

https://www.youtube.com/c/DanielRosehillVideo/about

Social media and more:

https://www.danielrosehill.com

== Licensing / syndication / reproduction ==

Unless otherwise indicated, all videos I distribute through YouTube are licensed under the following Creative Commons license: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). 

For the full license, see: https://bit.ly/ncnd4bycc.