Semi-permeable Filters for Interior Region of Interest Dose Reduction in X-ray Microscopy
Channel: BVM Conference
Date: 2021-03-12

In osteoporosis research, the number and size of lacunae in cortical bone tissue are important characteristics of osteoporosis development. In order to reconstruct lacunae well in X-ray microscopy while protecting bone marrow from high-dose damage in in-vivo experiments, semi-permeable X-ray filters are proposed for dose reduction. Compared with an opaque filter, image quality with a semi-permeable filter is improved remarkably. For image reconstruction, both iterative reconstruction with reweighted total variation (wTV) and FDK reconstruction from penalized weighted least-square (PWLS) processed projections can reconstruct lacunae when the transmission rate of the filter is as small as 5%. However, PWLS is superior in computation efficiency.

References:
Huang Y. et al. (2021) Semi-permeable Filters for Interior Region of Interest Dose Reduction in X-ray Microscopy. In: Palm C., Deserno T.M., Handels H., Maier A., Maier-Hein K., Tolxdorff T. (eds) Bildverarbeitung für die Medizin 2021. Informatik aktuell. Springer Vieweg, Wiesbaden. https://doi.org/10.1007/978-3-658-33198-6_16