Friedel-Crafts Reactions" _ Easy Chemistians
Channel: Easy chemistian
Date: 01/11/2023

The Friedel-Crafts reaction is a powerful and versatile synthetic chemical transformation used to introduce various functional groups onto aromatic compounds. Named after its pioneers, Charles Friedel and James Crafts, this reaction involves the substitution of hydrogen atoms in an aromatic ring with different substituents, such as alkyl or acyl groups. It is a fundamental tool in organic chemistry and plays a crucial role in the synthesis of a wide range of organic compounds, including pharmaceuticals, fragrances, and agrochemicals.
The reaction proceeds through the use of a Lewis acid catalyst, typically aluminum chloride (AlCl3) or ferric chloride (FeCl3), which activates the electrophilic species (either an alkyl or acyl halide) and facilitates its attack on the electron-rich aromatic ring. This electrophilic aromatic substitution can lead to the formation of various substituted aromatic products.
Friedel-Crafts reactions have found applications in the synthesis of a multitude of compounds, from simple alkylbenzenes to complex natural products. They offer chemists a wide range of possibilities for functionalizing and modifying aromatic compounds, contributing significantly to the field of organic synthesis.
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