The pieces of the protein puzzle: tools for repeat proteins annotation
Channel: ISCB-SC Webinars
Date: 2021-03-16

Tandem repeat (TR) regions consist in the repetition of simple modules. Such arrangement confers unique structural and folding properties: stabilized by short-range contacts, they show a higher surface/volume ratio in comparison to globular proteins, and provide a versatile framework for protein interactions. TRs are central in cell signaling and regulation, distributed across functional pathways and perform functions that require quick adaptability. They are arranged as LEGO blocks to build diverse macromolecules and provide unique opportunities for protein engineering. We present the last version of RepeatsDB database, providing the largest collection of TR proteins detected from structures. It relies on computational tools and manual curation to detect TRs in the PDB, making it possible to compare unit positions, secondary structure, fold information and protein family annotation.