Angela Relogio & Janina Hesse: Time matters: Using computational matters to assess circadian time
Channel: NorthWestBiomathsDataScienceSeminars
Date: 26/02/2021

North West Seminar Series of Mathematical Biology and Data Science 

Monday, 16th November 2020 (hosted by Mirela Domijan) 

https://www.cms.livjm.ac.uk/APMSeminar/

Abstract:
Daily rhythms, or circadian rhythms, are generated by an endogenous timing mechanism, and differ between subjects. This timing mechanism is sensitive to external signals such as light, temperature, and food intake (so-called zeitgebers), thus aligning (entraining) the organism to the geophysical time. The influence of the circadian clock on health and disease has been increasingly investigated, both to optimize daily rhythms, as well as to improve treatment of certain pathologies including cancer. The personal biological time can be assessed by a variety of tools not yet commonly included in diagnostics. We discuss these tools with a focus on their applicability both regarding optimization of daily activities (e.g. exercise), as well as in a clinical context (e.g. optimization of cancer treatment).


Related publication:
Basti A, Yalçin M, Herms D, et al (2021). Diurnal variations in the expression of core-clock genes correlate with resting muscle properties and predict fluctuations in exercise performance across the day, BMJ Open Sport & Exercise Medicine 2021;7:e000876. doi: 10.1136/bmjsem-2020-000876
URL: https://bmjopensem.bmj.com/content/7/1/e000876