Sonja Lehtinen: Evolutionary ecology of antibiotic resistance
Channel: Centre International de Rencontres Mathématiques
Date: 2020-03-06

Antibiotic resistance is a serious public health concern. Responding to this problem effectively requires characterising the factors (i.e. evolutionary and ecological processes) that determine resistance frequencies. At present, we do not have ecologically plausible models of resistance that are able to replicate observed trends - we are therefore unable to make credible predictions about resistance dynamics. In this talk, I will present work motivated by three tends observed in Streptococcus pneumoniae resistance data: the stable coexistence of antibiotic sensitivity and resistance, variation between resistance frequencies between pneumococcal lineages and correlation in resistance to different antibiotics. I will propose that variation in the fitness benefit gained from resistance arising from variation in the duration of carriage of pneumococcal lineages is a parsimonious explanation for all three trends. This eco-evolutionary framework could allow more accurate prediction of future resistance levels and play a role in informing strategies to prevent the spread of resistance.

Recording during the meeting "Mathematical Modeling and Statistical Analysis of Infectious Disease Outbreaks" the February 17, 2020 at the Centre International de Rencontres Mathématiques (Marseille, France) Filmmaker: Guillaume Hennenfent Find this video and other talks given by worldwide mathematicians on CIRM's Audiovisual Mathematics Library: http://library.cirm-math.fr. And discover all its functionalities: - Chapter markers and keywords to watch the parts of your choice in the video - Videos enriched with abstracts, bibliographies, Mathematics Subject Classification - Multi-criteria search by author, title, tags, mathematical area