Neuert Lab Introduction
Channel: Neuert lab
Date: 2021-07-25

This video is a short summary abour the research areas and approaches in the Neuert lab
https://lab.vanderbilt.edu/neuert-lab/

Many human diseases are caused by cellular and molecular changes in signal transduction and gene regulatory pathways as a consequence of kinetic exposure of humans to harmful environmental conditions. However, when we try to understand molecular alternations that appear in disease cells, almost all biological studies today are performed in environments that are constant over time and may not represent physiologically relevant conditions. In addition, even within a group of individuals diagnosed with the same condition, the disease outcome and response to treatment at the whole body, organ, or cellular level can vastly differ. However, because most studies are based on population measurements, they assume that all cells of a specific type behave identically. To address these limitations, my lab aims to understand the fundamental mechanisms of signal transduction and gene expression in normal and disease physiology in the context of kinetics and variability. We do so by applying a quantitative framework to broad biological questions in model organisms and in healthy and diseased tissue. We combine a series of single-cell, single-molecule, and genome-wide approaches and complement these quantitative assays with in-depth computational data analysis, genetics, molecular biology, chemical profiling, and single-cell predictive computational modeling. The mentoring environment in the Neuert lab is dedicated to Diversity, Equity, and Inclusion.

Specific questions of interest are:
How do individual cells perceive physiologically relevant environments?
How do proteins generate dynamic behavior within a single cell?
How do cells regulate genes in physiologically relevant dynamic and stochastic environments?
How to computationally model and predict single-cell behavior to gain novel biological insight?