Fecal microbiota transplantation | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-06-06

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Fecal_microbiota_transplant


00:02:12 1 Definition
00:03:30 2 Medical uses
00:03:41 2.1 iClostridioides difficile/i infection
00:05:25 2.2 Ulcerative colitis and other gastrointestinal conditions
00:06:34 2.3 Autism
00:07:06 3 Adverse effects
00:07:54 4 Technique
00:08:42 4.1 Donor selection
00:09:46 4.2 Specimen preparation
00:11:35 4.3 Administration
00:12:01 5 Mechanism of action
00:14:26 6 History
00:17:59 7 Society and culture
00:18:10 7.1 Regulation
00:22:09 7.2 Stool banks
00:23:26 8 Research
00:24:17 9 Veterinary use
00:25:14 10 See also



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SUMMARY
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Fecal microbiota transplant (FMT), also known as a stool transplant, is the process of transplantation of fecal bacteria from a healthy individual into a recipient. FMT involves restoration of the colonic microflora by introducing healthy bacterial flora through infusion of stool, e.g. by colonoscopy, enema, orogastric tube or by mouth in the form of a capsule containing freeze-dried material, obtained from a healthy donor. The effectiveness of FMT has been established in clinical trials for the treatment of Clostridioides difficile infection (CDI), whose effects can range from diarrhea to pseudomembranous colitis.
Due to an epidemic of CDI in North America and Europe, FMT has gained increasing prominence, with some experts calling for it to become first-line therapy for CDI. In 2013 a randomized, controlled trial of FMT from healthy donors showed it to be highly effective in treating recurrent C. difficile in adults, and more effective than vancomycin alone. FMT has been used experimentally to treat other gastrointestinal diseases, including colitis, constipation, irritable bowel syndrome, and neurological conditions such as multiple sclerosis and Parkinson's. In the United States, the Food and Drug Administration (FDA) has regulated human feces as an experimental drug since 2013.  In the United Kingdom, FMT regulation is under the remit of the Medicines and Healthcare products Regulatory Agency.