Soliton model in neuroscience | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-12-30

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Soliton_model_in_neuroscience


00:02:50 1 History
00:04:37 2 Justification
00:06:59 3 Formalism
00:09:52 4 Role of ion channels
00:11:07 5 Application to anesthesia
00:12:27 6 Differences between model predictions and experimental observations
00:17:53 7 Action waves
00:18:32 8 See also
00:18:49 9 Sources



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SUMMARY
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The soliton hypothesis in neuroscience is a model that claims to explain how action potentials are initiated and conducted along axons based on a thermodynamic theory of nerve pulse propagation. It proposes that the signals travel along the cell's membrane in the form of certain kinds of solitary sound (or density) pulses that can be modeled as solitons. The model is proposed as an alternative to the  Hodgkin–Huxley model in which action potentials: voltage-gated ion channels in the membrane open and allow sodium  ions to enter the cell (inward current). The resulting decrease in membrane potential opens nearby voltage-gated sodium channels, thus propagating the action potential. The transmembrane potential is restored by delayed opening of potassium channels. Soliton hypothesis proponents assert that energy is mainly conserved during propagation except dissipation losses; however, measured temperature changes are also consistent with the Hodgkin-Huxley model.The soliton model ( and sound waves in general) depends on adiabatic propagation in which the energy provided at the source of excitation is carried adiabatically through the medium, i.e. plasma membrane. The measurement of a temperature pulse and the claimed absence of heat release during an action potential were the basis of the proposal that nerve impulses are an adiabatic phenomenon much like sound waves. Synaptically evoked action potentials in the electric organ of the electric eel are associated with substantial positive (only) heat production. In the garfish olfactory nerve, the action potential is associated with a biphasic temperature change; however, there is a net production of heat. These published results are consistent with the Hodgkin-Huxley Model and the authors interpret their work in terms of that model: The initial sodium current releases heat as the membrane capacitance is discharged; heat is absorbed during recharge of the membrane capacitance as potassium ions move with their concentration gradient but against the membrane potential. This mechanism is called the "Condenser Theory". Additional heat may be generated by membrane configuration changes driven by the changes in membrane potential. An increase in entropy during depolarization would release heat; entropy increase during repolarization would absorb heat.