Evaporative light scattering detector | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-06-05

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Evaporative_light_scattering_detector


00:01:14 Principles of operation



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SUMMARY
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An evaporative light scattering detector (ELSD) is a detector used in conjunction with high-performance liquid chromatography (HPLC), Ultra high-performance liquid chromatography (UHPLC), Purification liquid chromatography such as flash or preparative chromatography, countercurrent or centrifugal partition chromatographies and Supercritical Fluid chromatography (SFC). It is commonly used for analysis of compounds where UV detection might be a restriction and therefore used where compounds do not efficiently absorb UV radiation, such as sugars, antivirals, antibiotics, fatty acids, lipids, oils, phospholipids, polymers, surfactants, terpenoids and triglycerides. ELSDs is related to the charged aerosol detector (CAD) and like the CAD, falls under the category of destructive detectors.
An evaporative light scattering detector (ELSD) is able to detect all compound which are less volatile than the mobile phase, i.e. non volatile and semi-volatile compounds.