MHC-Class 1 | Structure and Function | Immunology | Basic Science Series
Channel: Basic Science Series
Date: 2020-11-27

0:00  Introduction
1:00  Location
1:20  Structure
1:34  Alpha Chain
1:56  How it Recognizes
2:03  Interaction in Alpha Chain
2:17  Bindings in Alpha Chain
2:44  Conclusion

MHC-Class 1 | Structure and Function | Immunology | Basic Science Series

MHC-Class-1 by Dr. Lokender Kumar Basic Science Series Chapter 31. In this presentation, we will focus on structure and function of major histocompatibility complex class-1 molecule in detail. We will also know about the interaction with CD 8 co receptor and the function of various domains of MHC class-1 molecule. So please watch the full presentation to understand the structure and functions of MHC class-1 molecule.

MHC class I molecules are heterodimers that means they are consist of two polypeptide chains, α chain and β2-microglobulin chain. 

Alpha chain contains 3 domain a1, a2 and a3. Alpha and beta macroglobulin chains are linked non-covalently via interaction of β2-microglobulin and the α3 domain
The α1 and α2 domains fold to make up a groove for peptides to bind. It is very important to note down that the α3 domain interacts with the CD8 co-receptor. 

The α3-CD8 interaction holds the MHC I molecule in place while the T cell receptor (TCR) on the surface of the cytotoxic T cell binds with α1-α2 chains and checks the coupled peptide for antigenicity. MHC class I molecule binds with peptides that are predominantly 8-10 amino acid in length but the binding of longer peptides have also been reported. 


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Reference: https://en.wikipedia.org/wiki/MHC_class_I