Diuretics - Physiology and Pharmacology
Channel: Liam Skoda
Date: 2023-09-30

This lecture aims to provide a conceptual overview of renal tubular physiology and the pharmacology of diuretics with an emphasis on use in the inpatient and critical care setting. Slides and animations are my own work and free for reuse (suggest using 4K version). Content developed during preparation for CICM primary exam. 

Minor graphical correction: In the transition animation visible around ~41.36 the label "cortical connecting duct" should read "cortical collecting duct". 

Review article link:
https://www.frontiersin.org/articles/10.3389/fneph.2022.879766/full

Further Reading Links:
https://derangedphysiology.com/main/home
@biomedsessions 
https://pbfluids.com/

00:00:00 Title
00:00:40 Terminology
00:01:31 Renal Anatomy and Blood Supply
00:03:17 Nephron Structure
00:05:31 Glomerular Filtration
00:07:42 Proximal Convoluted Tubule
00:17:13 Loop of Henle
00:17:41 Countercurrent Multiplier
00:21:23 Countercurrent Exchange
00:22:27 Urea Recycling
00:24:01 Thick Ascending Limb
00:27:41 Juxtaglomerular Apparatus 1
00:32:11 Renin-Angiotensin Signalling
00:33:01 Juxtaglomerular Apparatus 2
00:33:31 Early Distal Tubule
00:35:32 Late Distal Tubule
00:41:30 Cortical Collecting Duct
00:47:55 Inner Medullary Collecting Duct
00:49:27 Overview of Tubular Reabsorption
00:50:16 Fractional Excretion of Solute
00:53:31 Determinants of Urine Output
00:55:30 Osmotic Diuretics 
00:57:13 SGLT-2 Inhibitors
00:58:21 Carbonic Anhydrase Inhibitors
01:00:17 Loop Diuretics 
01:02:20 Thiazide/Thiazide-Like Diuretics
01:02:37 ENaC Blocker (Amiloride)
01:02:46 Mineralocorticoid Antagonists
01:03:23 V2 Antagonists
01:03:56 Solute Fractional Excretion Table
01:08:23 Diuretic Adaptation and Resistance
01:11:23 Optimisation Strategies
01:16:00 Review Article
01:16:37 Summary
01:18:09 References and Further Reading
01:21:01 End