Immunoglobulin Isotypes IgE, IgD and Antigen type|Immune response|Immunology|First Aid Lecture|Lec13
Channel: Dr. Jamil Lectures
Date: 30/03/2022

In this lecture we will discuss about Immunoglobulin isotypes IgE and IgD,their function and properties.Antigen type and memeory,Thymus Independent antigens and Thymus dependent antigens.

https://youtu.be/rUvYRSse2xg
https://youtu.be/s7Uu6_ILnf4
https://youtu.be/aP06bUvyqCA


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IgE immunoglobulin
It binds with mast cells and basophils,
It i cross-links when exposed to allergen, 
It is mediating immediate (type I) hypersensitivity through release of inflammatory mediators such as histamine. 
It contributes to  immunity to parasites by activating eosinophils.
IgD 
Its function is unclear and is found on surface of many B cells and in serum
Thymus-dependent  antigens
Example;Antigens containing a protein component (eg, Streptococcus pneumoniae PCV13 vaccine, polysaccharides conjugated to diphtheria toxin-like protein). 
Class switching and immunologic 
memory occur as a result of direct contact of B cells with Th2 cells.
Thymus-independent antigens
Example;antigens lacking a peptide component (eg, lipopolysaccharides from gram ⊝ bacteria);
It  cannot be presented by MHC to T cells. It is Weakly immunogenic; vaccines often require boosters and adjuvants (eg, capsular polysaccharide subunit of Streptococcus pneumoniae PPSV23 vaccine)

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