Curare | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-10-29

This is an audio version of the Wikipedia Article:
Curare

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SUMMARY
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Curare  or  is a common name for various plant extract alkaloid arrow poisons originating from Central and South America. These poisons function by competitively and reversibly inhibiting the nicotinic acetylcholine receptor (nAChR), which is a subtype of acetylcholine receptor found at the neuromuscular junction. This causes weakness of the skeletal muscles and, when administered in a sufficient dose, eventual death by asphyxiation due to paralysis of the diaphragm.
According to pharmacologist Rudolf Boehm's 1895 classification scheme, the three main types of curare are:
tube or bamboo curare (so named because of its packing into hollow bamboo tubes; main toxin is D-tubocurarine).
pot curare (originally packed in terra cotta pots; main alkaloid components are protocurarine, protocurine, and protocuridine). Protocurarine is the  active ingredient; protocurine is only weakly toxic, and protocuridine is not toxic.
calabash or gourd curare (originally packed into hollow gourds; main toxin is C-toxiferine I).Of these three types, some formulas belonging to the tube curare are the most toxic, relative to their LD50 values.