SIB Days 2020: Structural bioinformatics: innovative tools to address bio-macromolecular structure
Channel: SIB - Swiss Institute of Bioinformatics
Date: 01/07/2020

Parallel Session 4: Structural Biology

The extensive use of sequencing technologies is causing a renewed interest in structural
biology and bioinformatics. Three-dimensional structures of bio-macromolecules constitute
an invaluable source of information to understand and predict the consequences of
polymorphisms and somatic mutations, while they remain the cornerstone of structure-based drug design and protein engineering. Technical progress is providing an ever-increasing amount of high-quality experimental data, which requires computational approaches to process. These data are also being integrated with information regarding for instance biology and function, existing variants, and binding partners such as proteins or drug-like molecules. Moreover, theoretical prediction of bio-macromolecule tertiary and quaternary structures remains crucial to cover experimentally unexplored regions of the structural space. This session is dedicated to projects related to the collection, prediction, dissemination and use of bio-macromolecular structures.

Session Chairs: Chan Cao (Laboratory for Biomolecular Modeling, EPFL),  Vincent Zoete (Computer-aided molecular engineering, University of Lausanne)

Talks (click to access specific sections of the talk)
Session Introduction 00:00
Prediction of carbohydrate-binding proteins in microbial proteomes, François Bonnardel, Proteome Informatics Group, University of Geneva 01:48
State-of-the-art web services for modeling the structures of proteins that lack clear templates in the PDB, Luciano Abriata, Laboratory for Biomolecular Modeling, EPFL, Lausanne 18:09
Responses of ion channels to pH fluctuations investigated through molecular dynamics, Olivier Bignucolo, Molecular Modelling Group, University of Lausanne 35:25
Machine learning predicts immunoglobulin light chain toxicity through somatic mutations, Andrea Cavalli, Computational Structural Biology, Institute for Research in Biomedicine, 44:56
Addressing challenges in cancer immunotherapy with structural bioinformatics approaches, Marta Perez, Computer-aided molecular engineering, University of Lausanne 53:16
Enabling structure-guided life science research with the SWISS-MODEL Repository, Erblin Asllanaj, Computational Structural Biology Group, University of Basel 61:34


About the SIB Days: this internal conference of the SIB Swiss Institute of Bioinformatics is organized every two years. Its ambition? To give a voice to SIB's 80 Groups across Switzerland, through a diversity of bioinformatics topics, and to offer its 800 SIB Members an opportunity to meet and learn about each other’s research and activities in a friendly atmosphere. Due to this year’s events, the conference has taken place virtually for the first time, on 8-10 June 2020. Most of the talks could be made public post-event.


Read more about the SIB Days: https://www.sib.swiss/about-sib/news/10713-virtual-sib-days-2020-swiss-bioinformatics-highlights-recorded-sessions