The Complete Guide To The Ketogenic Diet New 2016 Update Review
Channel: Complete Guide To The Ketogenic Diet
Date: 02/11/2016

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Less carbs, more fat: ketogenic diet makes migraine patients' headaches disappear

The diet was originally developed for childhood epilepsy a century ago and is now studied to treat migraines.

Before the ketogenic diet became the latest low-carb diet trend, it was used to treat childhood epilepsy. Doctors had observed that fasting reduced the amount of seizures, and eating mainly fat and little else mimicked the effect of starvation in the brain. In recent years, researchers have made similar positive observations with migraines. Cherubino Di Lorenzo studies the effect of a ketogenic diet on migraine patients and, in his latest paper, their brains at the Sapienza University of Rome.

ResearchGate: What is a ketogenic diet? 

Cherubino di Lorenzo: The ketogenic diet is a particular nutritional regimen that mimics starvation by restricting carbohydrate intake. It was developed 95 years ago in order to treat drug-resistant epilepsy in children. Traditionally, the ketogenic diet is rich in fat and low in carbohydrates, but in the past decades another type of ketogenic diet was developed to treat obesity and metabolic syndrome: the low fat (10-15 grams/day) low carb (20-50 grams/day) diet, also known as the very low calorie ketogenic diet (VLCKD).

RG: What does this diet do to the body and the brain in particular?  

Di Lorenzo: During a ketogenic diet, carbohydrate restriction induces the fat metabolism to produce so-called ketone bodies. These ketone bodies act as a replacement for carbohydrates and fuel several types of cells, including neurons. In the classic ketogenic diet, the fat that’s taken in with the food is the source for the production of ketone bodies . In the very low calorie ketogenic diet, however, the ketone bodies are produced from fats in adipose tissue. You could think of this process as the body’s own biochemical liposuction. Each molecule of ketone bodies produces more energy than glucose, but less oxidative stress, so the brain and the muscles work more efficiently. This effect of ketone bodies as energetic boosters is very important in migraine patients, or migraineurs, because they have an energetic deficit in the brain. Ketone bodies also have an anti-inflammatory effect. This is also important because ‘sterile inflammation’ – inflammation caused by damage rather than by microbes – is at the heart of migraines. The ketone bodies dampen the neural inflammation that’s both common in epilepsy and migraines and modulate the cortical excitability, the firing rate of neurons.

RG: How did you get the idea to study the effects of a ketogenic diet on migraineurs? 

Di Lorenzo: Our interest in ketogenic diets was born in 2009. A common side effect of most drugs for migraine prophylaxis, including antidepressants, anti-epileptics, calcium antagonists, and beta-blockers, is weight gain. The problem: increased weight can also worsen headaches in these patients. For this reason, we recommended that overweight patients see a dietician prior to or during preventive treatment. One of these dieticians, Giulio Sirianni, observed that patients who underwent very low calorie ketogenic diets had fewer headaches. In most cases, the headaches even disappeared during the ketogenic phase of the diet.

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This video is supported by: https://www.researchgate.net/blog/post/less-carbs-more-fat-ketogenic-diet-treats-migraine-patients

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