Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder
Channel: Metabolic Health Summit
Date: 2022-08-16

“Maintaining a healthy gut barrier is key for heart and brain health,” asserts Dr. Rhonda Patrick, PhD of @FoundMyFitness.

In her keynote talk at #MHS2022, Dr. Patrick excavates new frontiers in metabolic health regarding intestinal permeability. Lipopolysaccharide (LPS) is an endotoxin present on the outer membrane of certain bacteria found in the gut microbiome. Many factors including psychological stress, a processed-food diet, and obesity can contribute to the production of LPS which promotes the break down of tight-junctions between intestinal cells leading to gut permeability.

Gut permeability opens the doorway for molecules that should be in the gut to have access to the entire body and often wreak havoc outside of their appropriate home. LPS in the brain causes neuroinflammation, which then results in more intestinal permeability and contributes to the vicious cycle. LPS from intestinal permeability shifts immune cells from a protective mode to attack mode and propagates further inflammation which we know is linked to accelerating aging and poorer metabolic health.

Dr. Patrick details the relationship between intestinal permeability and the bacterial link to aging, brain barrier dysfunction, and metabolic disorder in addition to interventions you can implement to prevent this vicious cycle.

We recorded all of the amazing content from Metabolic Health Summit 2022, and it’s now available on our virtual platform for you to watch and enjoy! All content will be available for viewing through October of 2022 and CME credit can be claimed during that time. This activity is jointly provided by Cedars-Sinai Medical Center of Los Angeles and Metabolic Health Initiative. Earn up to a maximum of 22 AMA PRA Category 1 Credits™ (Virtual Access + CME Ticket). To watch Dr. Patrick’s full presentation + more than 40 other lectures, in-depth panels, and special interest forums from Metabolic Health Summit 2022, please visit www.metabolichealthsummit.com.