Aging-US | Rejuvant®: A Promising Anti-Aging Supplement
Channel: Aging (Aging-US)
Date: 2021-12-02

Aging-US published this trending priority research paper selected as the cover for Volume 13, Issue 22, entitled, “Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test” by researchers from TruMe Inc., Alameda, CA; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University Singapore, Singapore; Ponce de Leon Health, Fernandina, FL; Centre for Healthy Longevity, National University Health System, Singapore; Singapore Institute for Clinical Sciences, A*STAR, Singapore.

Abstract
The search continues for possible interventions that delay and/or reverse biological aging, resulting in extended healthspan and lifespan. Interventions delaying aging in animal models are well established; however, most lack validation in humans. The length of human lifespan makes it impractical to perform survival analysis. Instead, aging biomarkers, such as DNA methylation (DNAm) clocks, have been developed to monitor biological age. Herein we report a retrospective analysis of DNA methylation age in 42 individuals taking Rejuvant®, an alpha-ketoglutarate based formulation, for an average period of 7 months. DNAm testing was performed at baseline and by the end of treatment with Rejuvant® supplementation. Remarkably, individuals showed an average decrease in biological aging of 8 years (p-value=6.538x10-12). Furthermore, the supplementation with Rejuvant® is robust to individual differences, as indicated by the fact that a large majority of participants decreased their biological age. Moreover, we found that Rejuvant® is of additional benefit to chronologically and biologically older individuals. While continued testing, particularly in a placebo-controlled design, is required, the nearly 8-year reversal in the biological age of individuals taking Rejuvant® for 4 to 10 months is noteworthy, making the natural product cocktail an intriguing candidate to affect human aging.

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DOI - https://doi.org/10.18632/aging.203736

Full Text - https://www.aging-us.com/article/203736/text

Correspondence to: Brian K. Kennedy email: bkennedy@nus.edu.sg and Yelena V. Budovskaya email: yelena@trumelabs.com

Keywords: aging, DNA methylation, alpha-ketoglutarate (AKG), biologic age, Rejuvant

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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