No end in sight for gene function discovery
Channel: Togotv
Date: 04/07/2017

http://togotv.dbcls.jp/20170707.html

NIG International symposium 2017, Commemorating the 30th Anniversary of DDBJ was held in Mishima Citizens Cultual Hall in shizuoka, Japan. On the third day of the symposium (29 May), oral sessions were held. 
In this talk, Frank Eisenhaber makes a presentation entitled "No end in sight for gene function discovery: How long will it take to understand the human genome and what can be learned from the GAA1/GPAA1 function discovery story?". (37:23) 

1. What began with the DNA Database of Japan …～ (00:05) 
2. 30 years of DDBJ～ (02:10) 
3. Future developments: Pivot moving to Asia～ (02:40) 
4. Opportunity: Beijing Institute of Genomics Chinese Academy of China～ (03:47) 
5. BMS in Singapore～ (04:18) 
6. Bioinformatics Institute(BII) A*STAR, Singapore～ (04:22) 
7. Mission of BII A*STAR～ (04:29) 
8. BII’s Divisions～ (07:20) 
9. Kye numbers 2017～ (08:23) 
10. BII’s science: Publications 2001-2016～ (10:21) 
11. Natural Organism Library since 2014～ (10:44) 
12. Clinical Data Management: Translational Informatics Management System(TIMS)～ (11:31) 
13. Translational Informatics Management System(TIMS): Outreach to clinical community～ (13:07) 
14. General data management issues Example1: OMICS sample mislabeling～ (13:28) 
15. General data management issues Example2: OMICS sample QC failure～ (14:44) 
16. General data management issues Example3: Subject information inconsistencies-race, gender, height～ (15:19) 
17. No end in sight for gene function discovery: How long will it take to understand the human genome?～ (16:13) 
18. Hierarchical Description of Gene/Protain Function～ (16:42) 
19. Chronic Myeloid Leukemia～ (17:37) 
20. Technology phase transitions since 1990 …～ (18:02) 
21. Optimistic view of Illumina CEO Jay Flatley～ (18:27) 
22. Historical trends in storage prices versus DNA sequencing costs～ (19:26) 
23. A decade later …～ (20:30) 
24. Why is the progress in applications limited…～ (21:29) 
25. Human genome encoded functions: When will we know them all?～ (21:32) 
26. The human genome - not only~25000 genes～ (21:59) 
27. When will we understand the human genome?～ (22:36) 
28. What is the most impactful and urgent research task in life sciences?～ (23:18) 
29. Protein function predication:～ (24:02) 
30. GPI-lipid anchoring by the transeamidase complex the ER;folate receptor α-isoform～ (24:47) 
31. 2003-2014: The transaminase complex～ (26:06) 
32. The transaminase complex～ (27:22) 
33. ANNOTATOR: sequence features GPAA1_HUMAN～ (28:59) 
34. The transaminase complex 2014～ (31:51) 
35. Function of GPAA1/GAA1～ (32:28) 
36. Conclusions～ (33:28) #togotv#DBCLS#bioinformatics #togotv#DBCLS#bioinformatics