Gene-environment interactions | Wikipedia audio article
Channel: wikipedia tts
Date: 17/06/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Gene%E2%80%93environment_interaction


00:02:37 1 History of the definition
00:04:46 2 Definitions
00:06:23 3 Epidemiological models of GxE
00:08:25 4 Methods of analysis
00:08:35 4.1 Traditional genetic designs
00:08:46 4.1.1 Adoption studies
00:09:26 4.1.2 Twin studies
00:09:56 4.1.3 Family studies
00:10:30 4.2 Molecular analyses
00:10:39 4.2.1 Interaction with single genes
00:11:47 4.2.2 Interaction with multiple genes
00:12:37 4.2.3 Genome-wide association studies and genome wide interaction studies
00:13:26 5 Controversies
00:13:36 5.1 Lack of replication
00:14:26 5.2 Additive vs multiplicative model
00:15:34 6 Gene b×/b environment b×/b environment interactions
00:16:22 7 Medical significance
00:19:53 8 Examples
00:25:32 9 See also



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SUMMARY
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Gene–environment interaction (or genotype–environment interaction or GxE or G×E) is when two different genotypes respond to environmental variation in different ways. A norm of reaction is a graph that shows the relationship between genes and environmental factors when phenotypic differences are continuous. They can help illustrate GxE interactions. When the norm of reaction is not parallel, as shown in the figure below, there is a gene by environment interaction. This indicates that each genotype responds to environmental variation in a different way. Environmental variation can be physical, chemical, biological, behavior patterns or life events.

Gene–environment interactions are studied to gain a better understanding of various phenomena. In genetic epidemiology, gene–environment interactions are useful for understanding some diseases. Sometimes, sensitivity to environmental risk factors for a disease are inherited rather than the disease itself being inherited. Individuals with different genotypes are affected differently by exposure to the same environmental factors, and thus gene–environment interactions can result in different disease phenotypes. For example, sunlight exposure has a stronger influence on skin cancer risk in fair-skinned humans than in individuals with darker skin.These interactions are of particular interest to genetic epidemiologists for predicting disease rates and methods of prevention with respect to public health. The term is also used amongst developmental psychobiologists to better understand individual and evolutionary development.Nature versus nurture debates assume that variation in a trait is primarily due to either genetic differences or environmental differences. However, the current scientific opinion holds that neither genetic differences nor environmental differences are solely responsible for producing phenotypic variation, and that virtually all traits are influenced by both genetic and environmental differences.Statistical analysis of the genetic and environmental differences contributing to the phenotype would have to be used to confirm these as gene–environment interactions. In developmental genetics, a causal interaction is enough to confirm gene–environment interactions.