A Single Test Detects Multiple Cancers | Lifespan News
Channel: Lifespan News
Date: 2021-06-22

The biotech company GRAIL made history earlier this month by developing the first commercially available blood test able to detect several types of cancer. Although with varying degrees of sensitivity, this new test can detect cancers even at early stages, something that was just not possible for many cancer types until now. The new test, called Galleri, will surely contribute to saving many lives, although GRAIL themselves warn that it is a tool that should complement existing detection methods, and not replace them just yet. 

In other news, scientists have found similarities between artificially restricted cerebral blood flow and the reduced blood flow associated with aging. Through a surgical procedure, they restricted blood flow to the brains of younger mice, and observed effects similar to those observed in older mice as blood flow to their brains is reduced because of aging—such as similar expression levels of genes related to mitochondrial oxidation, the production of NAD+ from NADH, and the basic synthesis of ATP.

Finally, Calico scientists discovered something new about transient cellular reprogramming: unlike what we previously thought, it appears that this procedure does reset cellular identity, although only temporarily, which bears a risk of oncogenic mutations. In a preprint they published recently, they outline their experiment and a proposed way to get around this problem.

CHAPTERS
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0:00 Intro
0:45 First Multi-Cancer Blood Test Available Now
2:41 Brain Blood Flow Restriction Resembles Brain Aging in Mice
4:12 Calico Scientists Develop Safer Cellular Reprogramming

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First Multi-Cancer Blood Test Available Now:
https://www.lifespan.io/news/first-multi-cancer-blood-test-available-now/

Brain Blood Flow Restriction Resembles Brain Aging in Mice:
https://www.lifespan.io/news/brain-blood-flow-restriction-resembles-brain-aging-in-mice/

Calico Scientists Develop Safer Cellular Reprogramming:
https://www.lifespan.io/news/calico-scientists-develop-safer-cellular-reprogramming/

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Music: "Retro 80s technology" by Eric Matyas

Other sources:
https://grail.com/press-releases/grail-presents-interventional-pathfinder-study-data-at-2021-asco-annual-meeting-and-introduces-galleri-a-groundbreaking-multi-cancer-early-detection-blood-test/
https://open.spotify.com/episode/0Gifr7mhEsQBI5oGzJomz2
https://www.aging-us.com/article/203123/text
https://www.biorxiv.org/content/10.1101/2021.05.21.444556v2
https://www.calicolabs.com/
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#cancer #brain #rejuvenation #yamanaka #google #calico #aging