Cannabinoid receptor type 1 | Wikipedia audio article
Channel: wikipedia tts
Date: 11/12/2018

This is an audio version of the Wikipedia Article:
Cannabinoid receptor type 1


00:00:47 1 Structure
00:01:37 2 Mechanism
00:04:22 3 Expression
00:05:18 3.1 Brain
00:06:26 3.1.1 Hippocampal formation
00:07:58 3.1.2 Basal ganglia
00:09:07 3.1.3 Cerebellum and neocortex
00:10:04 3.2 Spine
00:11:06 3.3 Other
00:11:53 4 Function
00:12:02 4.1 Health and disease
00:13:26 4.2 Anxiety response to novelty
00:15:17 4.3 Gastrointestinal activity
00:16:33 4.4 Cardiovascular activity
00:17:14 4.5 Plasticity
00:18:54 4.6 Motor control
00:19:23 4.7 Drug and behavioral addictions
00:20:00 4.8 Olfaction
00:20:37 5 Use of antagonists
00:21:20 6 Ligands
00:21:29 6.1 Agonists
00:21:41 6.1.1 Selective
00:21:57 6.1.2 Unspecified efficacy
00:22:16 6.1.3 Partial
00:22:24 6.1.3.1 Endogenous
00:22:34 6.1.3.2 Phyto/synthetic
00:22:47 6.1.4 Full
00:22:54 6.1.4.1 Endogenous
00:23:04 6.1.4.2 Phyto/synthetic
00:23:25 6.1.5 Allosteric agonist
00:23:37 6.2 Antagonists
00:23:58 6.3 Inverse agonists
00:24:10 6.4 Allosteric modulators
00:24:19 7 Binding affinities
00:24:28 8 Evolution
00:25:08 9 See also



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SUMMARY
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Cannabinoid receptor type 1 (CB1), also known as cannabinoid receptor 1, is a G protein-coupled cannabinoid receptor that in humans is encoded by the CNR1 gene. The human CB1 receptor is expressed in the peripheral nervous system and central nervous system. It is activated by: endocannabinoids, a group of retrograde neurotransmitters that include anandamide and 2-arachidonoylglycerol (2-AG); plant phytocannabinoids, such as the compound THC which is an active ingredient of the psychoactive drug cannabis; and, synthetic analogs of THC. CB1 is antagonized by the phytocannabinoid tetrahydrocannabivarin (THCV).The primary endogenous agonist of the human CB1 receptor is anandamide.