Complement component 4 | Wikipedia audio article
Channel: wikipedia tts
Date: 17/01/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Complement_component_4


00:01:33 1 History
00:09:14 2 Structure
00:16:50 3 Function and mechanism
00:21:33 4 Clinical significance
00:25:17 5 See also



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SUMMARY
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Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of critical functions in immunity, tolerance, and autoimmunity with the other numerous components. Furthermore, it is a crucial factor in connecting the recognition pathways of the overall system instigated by antibody-antigen (Ab-Ag) complexes to the other effector proteins of the innate immune response. For example, the severity of a dysfunctional complement system can lead to fatal diseases and infections. Complex variations of it can also lead to schizophrenia. Yet, the C4 protein derives from a simple two-locus allelic model, the C4A-C4B genes, that allows for an abundant variation in the levels of their respective proteins within a population. Originally defined in the context of the Chido/Rodgers blood group system, the C4A-C4B genetic model is under investigation for its possible role in schizophrenia risk and development.