Epigenetics: How Genes and Environment Interact - Randy Jirtle, Ph.D., Duke University
Channel: CellWellbeing S-Drive - La rivoluzione Epigenetica
Date: 27/03/2022

Epigenetics: How Genes and Environment Interact

Air date:  Wednesday, April 18, 2012, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local  

Category:  Wednesday Afternoon Lectures  
Description:  Human epidemiological and animal experimental data indicate that the risk of developing adult onset diseases and neurological disorders is influenced by persistent adaptations to prenatal and early postnatal environmental exposures. One group of epigenetically regulated genes that potentially links environmental exposures early in development to adult diseases are those with metastable epialleles. These genes have highly variable expression because of stochastic allelic changes in the epigenome rather than mutations in the genome. The viable yellow agouti (Avy) mouse harbors a metastable Agouti gene because of an upstream insertion of a transposable element. We have used the Avy mouse to investigate the importance of epigenetic alterations in determining adult disease risk in response to early developmental exposure to both chemical and physical agents. The importance these studies with regards to human health and disease will be discussed. 

The NIH Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. 

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The NIH Director's Wednesday Afternoon Lecture Series  
Author:  Randy Jirtle, Ph.D., Duke University  
Runtime:  00:58:00  
Permanent link:  http://videocast.nih.gov/launch.asp?1...