Do Broken Mitochondria Make You Age?
Channel: Lifespan News
Date: 08/07/2021

Do mitochondrial mutations matter in aging? For the longest time, we thought the answer was "yes". Mitochondrial mutations are a hallmark of aging, and scientists are at work to try to fix it. But new research suggests that their effect might be indirect and that nuclear DNA is what really matters.

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SOURCES AND FURTHER READING
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Hämäläinen, RH, Landoni, JC, Ahlqvist, KJ, Goffart, S, Ryytty, S, et al. (2020) Defects in mtDNA replication challenge nuclear genome stability through nucleotide depletion and provide a unifying mechanism for mouse progerias. Nature Metabolism doi: 10.1038/s42255-019-0120-1
https://www.nature.com/articles/s42255-019-0120-1

Sharma, S., Koolmeister, C, Tran, P, Nilsson, AK, Larsson, NG, and Chabes, A. (2020) Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos. Nature Metabolism doi: 10.1038/s42255-020-0264-z
https://www.nature.com/articles/s42255-020-0264-z

Hämäläinen, RH, Landoni, JC, Ahlqvist, KJ, Goffart, S, Ryytty, S, et al. (2020) Reply to: Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos. Nature Metabolism doi: 10.1038/s42255-020-0265-y
https://www.nature.com/articles/s42255-020-0265-y

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#mitochondria #aging #ROS #oxidation #DNA #mutations #lifeextension