Chemoreceptor trigger zone | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-06-06

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Chemoreceptor_trigger_zone


00:01:14 1 Evolutionary significance
00:03:15 2 Chemoreception
00:06:37 3 Communication
00:10:03 3.1 Phosphodiesterases
00:11:32 3.2 H-channels
00:12:50 4 The vomiting center of the brain
00:13:58 5 Damage to the CTZ
00:15:30 6 Antiemetic medications
00:17:04 7 Antiemetic drugs coupled with pain relieving medications
00:17:56 8 Chemotherapy
00:18:31 9 See also



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SUMMARY
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The chemoreceptor trigger zone (CTZ) is an area of the medulla oblongata that receives inputs from blood-borne drugs or hormones, and communicates with other structures in the vomiting center to initiate vomiting. The CTZ is located within the area postrema, which is on the floor of the fourth ventricle and is outside of the blood–brain barrier. It is also part of the vomiting center itself. The neurotransmitters implicated in the control of nausea and vomiting include acetylcholine, dopamine, histamine (H-1 receptor), substance P (NK-1 receptor), and serotonin (5-HT3 receptor). There are also opioid receptors present, which may be involved in the mechanism by which opiates cause nausea and vomiting. The blood–brain barrier is not as developed here, therefore drugs such as dopamine which cannot normally enter the CNS may still stimulate the CTZ.