ANTI ANGINAL DRUGS, MECHANISM, WORKING, CLASSIFICATION, DOSE, SIDE-EFFECTS, BASIC USE, INDICATIONS
Channel: PHARMAROCKS THE WAY OF SUCCESS
Date: 2021-01-27

ANTI-ANGINAL DRUGS,

ANTI-ANGINAL DRUGS WORKING, 
ANTI-ANGINAL DRUGS CLASSIFICATION, 
ANTI-ANGINAL DRUGS DOSE, 
ANTI-ANGINAL DRUGS SIDE-EFFECTS, 
ANTI-ANGINAL DRUGS BASIC USE, 
ANTI-ANGINAL DRUGS INDICATIONS,

#Antianginal_drugs 
Antianginal drugs are those that prevent, abort or terminate attacks of angina pectoris.
Angina pectoris is the medical term for chest pain or discomfort due to coronary heart disease. 
It occurs when the heart muscle doesn't get as much blood as it needs

#ANGINA_PECTORIS 
Angina pectoris is a pain syndrome due to induction of an adverse oxygen supply/demand situation in a portion of the myocardium. 
This usually happens because one or more of the heart's arteries is narrowed or blocked
It is also called ischemia.

ANGINA PECTORIS 
Angina is a symptom of coronary artery disease.
Angina is the chest pain that occurs due to imbalance between oxygen supply and demand.
In angina, there is a fixed atherosclerotic narrowing of the coronary arteries

ANTIANGINAL DRUGS 
FOLLOWING ARE THE MEDICATIONS USE IN ANGINA
Nitrates,
Aspirin,
Beta blockers,
Calcium channel blockers,
Blood pressure-lowering medications,
Ranolazine (Ranexa),
Statins,

NITRATES FOR ANGINA PECTORIS 
Following are important compounds in this category.
Glyceryl trinitrate
#nitroglycerine
Isosorbide dinitrate  (IDN)
Isosorbide mononitrate (IMN)
Erythrityl trinitrate
Pentaerythritol tetranitrate
Amyl nitrite

CALCIUM CHANNEL BLOCKERS
Verapamil, diltiazem and long acting DHPs (dihydropyridines) can be used in angina. 
Short acting DHPs like nifedipine should be avoided because these can accentuate the symptoms of angina by causing tachycardia.

BETA BLOCKERS FOR ANGINA PECTORIS 
Propranolol, atenolol & metoprolol
By slowing the heart rate, beta blockers reduce the oxygen demand of the heart and reduce the frequency of angina attacks in patient with angina pectoris 
Guidelines recommend beta blockers as first-line treatment in patients with angina either on their own or in combination with a calcium channel blocker.

POTASSIUM CHANNEL OPENERS
Nicorandil is the agent that causes coronary dilation by activating myocardial ATP sensitive K+ channels. 
It works by relaxing and widening our blood vessels, which increases the supply of blood and oxygen to our heart. 
This helps reduce the chest pain angina causes.

RANOLAZINE
By reducing the flow of calcium into the cells, ranolazine is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

NEW DRUGS FOR ANGINA PECTORIS 
Ivabradine is a new drug for angina. 
It is known as  bradycardiac agent (as it decreases heart rate without affecting the conduction or contractility)

Fasudil is a selective Rho A/Rho kinase (ROCK) inhibitor. 
ROCK is an enzyme that plays important role in vasoconstriction and cardiac remodeling.

👨🏼‍🏫 THIS EXPERT LECTURE BY 👨🏼‍🏫

MR AMAR M RAVAL 
ASSISTANT PROFESSOR
FOUNDER PHARMAROCKS
PHD SCOLAR (GTU AHMEDABAD)
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