FLUCONAZOLE, ANTIFUNGAL ANTIBIOTIC, BASIC USE, DOSE, फ्लुकोनाजोल एंटीबायोटिक की जानकारी सरल भाषा में
Channel: PHARMAROCKS THE WAY OF SUCCESS
Date: 2021-03-30

FLUCONAZOLE, ANTIFUNGAL ANTIBIOTIC, BASIC USE, DOSE, फ्लुकोनाजोल एंटीबायोटिक की जानकारी सरल भाषा में

FLUCONAZOLE DRUG
Fluconazole is an antifungal medication used for a number of fungal infections.
It is Triazoles Antifungal Drugs
It have systemic effects on body
Fluconazole is used to prevent and treat a variety of fungal and yeast infections. 
It works by stopping the growth of certain types of fungus.

FLUCONAZOLE DOSAGE FORM
Fluconazole tablets,
Fluconazole capsule,
Fluconazole cream,
Fluconazole gel,
Fluconazole Injection,
Fluconazole eye drops,

FLUCONAZOLE BASIC USE
Candidiasis,
Blastomycosis,
Coccidiodomycosis, 
Cryptococcosis, 
Histoplasmosis, 
Dermatophytosis,
Pityriasis versicolor.

FLUCONAZOLE MEDICINE
It is a water-soluble triazole having a wider range of activity than ketoconazole; 
Indications include cryptococcal meningitis, systemic and mucosal candidiasis in both normal and immunocompromised patients, 
Coccidioidal meningitis and some tinea infections.

FLUCONAZOLE MEDICINE FACTS
Fluconazole is 94% absorbed
oral bioavailability is not affected by food or gastric pH. 
It is primarily excreted unchanged in urine with a t½ of 25–30 hr. 
Fungicidal concentrations are achieved in nails, vagina and saliva; penetration into brain and CSF is good. 
Dose reduction is needed in renal impairment.

FLUCONAZOLE DOSE AND USE
Fluconazole can be administered orally as well as i.v. (in severe infections).
A single 150 mg oral dose can cure vaginal candidiasis with few relapses.
Oral fluconazole (100 mg/day for 2 weeks) is highly effective in oropharyngeal candidiasis.
Taken orally by patient 100 mg.

Fluconazole (100 mg/day) for 2–3 weeks is the first line treatment for candida esophagitis
Most tinea infections and cutaneous candidiasis can be treated with 150 mg weekly fluconazole for 4 weeks.

FLUCONAZOLE DOSE AND USE
For disseminated candidiasis, cryptococcal/ coccidioidal meningitis and other systemic fungal infections the dose is 200–400 mg/day for 4–12 weeks or longer.
An eye drop is useful in fungal keratitis.

FLUCONAZOLE DURING PREGNANCY
A single dose of fluconazole 150 mg to treat vaginal yeast infection during pregnancy does not appear to be associated with the birth defects. 
Patients should notify their healthcare professional if they are pregnant or become pregnant while taking fluconazole.

FLUCONAZOLE MECHANISM OF ACTION
Fluconazole is a fluorine-substituted, bis-triazole antifungal agent. 
Its mechanism of action, like that of other azoles, involves interruption of the conversion of lanosterol to ergosterol via binding to fungal cytochrome   P-450 and subsequent disruption of fungal membranes.

FLUCONAZOLE SIDE EFFECTS
Nausea,
Vomiting, 
Abdominal Pain, 
Rash,
Headache,
Diarrhea
Weakness.

FLUCONAZOLE CONTRAINDICATIONS
Low amount of magnesium in the blood.
Low amount of potassium in the blood.
Torsades de pointes, a type of abnormal heart rhythm.
Prolonged qt interval on EKG.
Abnormal EKG with qt changes from birth.
Abnormal liver function tests.
Pregnancy (only single dose recomanded)
Chronic kidney disease stage 3a (moderate)

#FLUCONAZOLE
#Fungal_infection
#फ्लुकोनाजोल_एंटीबायोटिक

👨🏼‍🏫 THIS EXPERT LECTURE BY 👨🏼‍🏫

MR AMAR M RAVAL 
ASSISTANT PROFESSOR
FOUNDER PHARMAROCKS
PHD SCOLAR (GTU AHMEDABAD)
☎️ CONTACT: 9016312020

📱 PHARMAROCKS E-LEARNING APP 

📚 STUDY MATERIAL
👨🏼‍🏫 VIDEO LECTURE
📊 TEST SERIES

Available for Android and app iPhone & ipad

📱 ANDROID APP LINK https://play.google.com/store/apps/details?id=co.april2019.pharma

📲 APPLE iPhone LINK
https://apps.apple.com/in/app/my-institute/id1472483563

📝 Org Code for iPhone =  PHARMA

☎️ HELPLINE 9426180836