Perivascular space | Wikipedia audio article
Channel: wikipedia tts
Date: 02/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Perivascular_space


00:01:23 1 Structure
00:04:55 2 Function
00:07:35 3 Clinical significance
00:08:36 3.1 Senescence
00:09:46 3.2 Symptoms of dilation
00:11:29 3.3 Associated disorders
00:13:01 4 Current research
00:13:11 4.1 Causes of dilated VRS
00:14:15 4.2 Association of dilated VRS and other diseases
00:14:35 4.2.1 Dementia
00:15:45 4.2.2 Alzheimer's disease
00:17:16 4.2.3 Stroke
00:18:53 4.2.4 Multiple sclerosis
00:19:41 4.2.5 Autism
00:20:11 5 History



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SUMMARY
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A perivascular space, also known as a Virchow–Robin space, is a fluid-filled space surrounding certain blood vessels in several organs, potentially having an immunological function, but more broadly a dispersive role for neural and blood-derived messengers. The brain pia mater is reflected from the surface of the brain onto the surface of blood vessels in the subarachnoid space. In the brain, perivascular cuffs are regions of leukocyte aggregation in the perivascular spaces, usually found in patients with viral encephalitis.
Perivascular spaces vary in dimension according to the type of blood vessel. In the brain where most capillaries have an imperceptible perivascular space, select structures of the brain, such as the circumventricular organs, are notable for having large perivascular spaces surrounding highly permeable capillaries, as observed by microscopy. The median eminence, a brain structure at the base of the hypothalamus, contains capillaries with wide perivascular spaces.In humans, perivascular spaces surround arteries and veins can usually be seen as areas of dilatation on MRI images.  While many normal brains will show a few dilated spaces, an increase in these spaces may correlate with the incidence of several neurodegenerative diseases, making the spaces a topic of research.