Live Longer? Cellular Reprogramming Extends Lifespan in Study!
Channel: Lifespan News
Date: 2023-02-04

Cellular reprogramming is one of the hottest topics in longevity science right now. In fact billions of dollars are flowing into this technology and companies like Altos Labs, reportedly backed by Jeff Bezos. Now, a new preprint study describes how using gene therapy to induce reprogramming can increase the lifespans of mice.

In this study, wild-type mice were given an adeno-associated virus (AAV) to modify wild-type mice so that they express three Yamanaka Factors, O S & K in the presence of the antibiotic doxycycline. The missing Yamanaka factor, M, was omitted in this study potentially because overexpression has been linked to cancer. 

The doxycycline was administered in carefully timed doses in order to spur partial, rather than total, reprogramming. Both the control group and the treatment group were injected with doxycycline in weekly on/off cycles. By itself, doxycycline was not found to significantly alter the lifespan of mice. However, the genetically modified mice experienced significantly reduced frailty and increased lifespans to over 124 weeks.

Other benefits were visible at the epigenetic level. The genetically modified mice had significantly less age acceleration according to the Lifespan Uber Clock, an epigenetic clock trained on these tissues. A related experiment on human epidermal cells showed similar benefits, with a substantially reduced predicted age.

Teratomas, a type of tumor that can contain hair, muscle, teeth and more, have been known to occur with uncontrolled OSK expression. Thankfully the researchers note that there were no significant side effects in any of the treated animals in this study.

This study was relatively brief and simple compared to most studies of its kind, but the results are clear and easy to interpret. This research shows that OSK induction can be used to increase the lifespan of living animals.

It is clear that the authors' biotechnology company, Rejuvenate Bio, wants to pursue this potentially groundbreaking approach in human beings. Only clinical trials will be able to determine if lifespan-related, frailty, and epigenetic metrics can truly be improved in people.

SOURCES AND FURTHER READING
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Gene Therapy to Induce Epigenetic Reprogramming - https://www.lifespan.io/news/gene-therapy-to-induce-epigenetic-reprogramming/

Gene Therapy Mediated Partial Reprogramming Extends Lifespan and Reverses Age-Related Changes in Aged Mice - https://www.biorxiv.org/content/10.1101/2023.01.04.522507v1.full

Science to Save the World: Can Old Cells be Young Again? | Yamanaka Factors & Cellular Reprogramming - https://youtu.be/cMHidJukbgo

Lifespan News: Prevent Aging within 20 Years? - Altos Labs' Cellular Reprogramming Excitement - https://youtu.be/UxVU3aEB9Mc

https://www.rejuvenatebio.com/

https://altoslabs.com/

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