BEMC FEB 2021 - Stefan Konigorski - "Digital N-of-1 Trials"
Channel: Berlin Epidemiological Methods Colloquium
Date: 2021-02-16

Stefan Konigorski, Potsdam, Germany
“Traditionally, guidelines and recommendations on health interventions have been obtained from studies of large groups of individuals. However, the derived average intervention effects do not allow meaningful insights on whether an intervention will help a given individual. N-of-1 trials are multi-crossover randomised controlled trials in a single participant which allow investigating individual-level intervention effects. Series of N-of-1 trials can then be aggregated to obtain population-level effect estimates. In this talk, I will present our open-source platform StudyU (arxiv.org/abs/2012.14201) which allows to digitally design, publish, and conduct N-of-1 trials. I will describe appropriate statistical methods for the analysis and discuss how this platform might be helpful to bridge individual-level and population-level studies.”