TPP1 Final DOM Poster 2021
Channel: Pattra Chun-on
Date: 2021-03-25

Telomerase is a unique reverse transcriptase that is responsible for maintaining telomeres. Telomerase reactivation has been implicated in human tumorigenesis. Somatic mutations in the TERT promoter are found in the majority of human melanomas and increase gene expression. A subset of melanomas do not contain TERT promoter mutations and the mechanism of telomere maintenance in these cells is unknown. TPP1 is a component of the shelterin complex that coats telomeres and is essential for their function.