New Glutathione Data! - GlyNAC Shows 24% Mouse Lifespan Extension in Mice
Channel: Lifespan News
Date: 2022-03-28

Scientists studying glutathione precursors have demonstrated some of the best life extension results ever achieved in mice - increasing their lifespan by 24% - and they already have studies showing positive effects in humans.

Glutathione levels decline with age, so supplementing it could plausibly affect other processes of aging. In a study conducted by scientists from Baylor College of Medicine in Houston, supplementation of glutathione had a drastic effect on the lifespan of wild-type mice.

This study used GlyNAC, a combination of two Glutathione precursors, glycine and N-acetylcysteine, or NAC). GlyNAC has already been an object of several studies. The same group that is behind this new paper has previously shown that continuous GlyNAC supplementation  in humans alleviates mitochondrial dysfunction and improves mitophagy , nutrient sensing, and genome stability.

For this study, the researchers took the study back to mice because humans are so long-lived that it makes studying any intervention’s direct effect on lifespan extremely difficult.

The researchers ran two studies simultaneously, one dedicated solely to determining the effect of GlyNAC on lifespan and the second one on various other parameters. In the first study, 32 mice were equally divided between the study group and the control group. At the age of 65 weeks, which is mid-life by mouse standards, 8 males and 8 females started receiving GlyNAC with food. Supplementation continued until the mice died of age-related diseases.

Mice on GlyNAC lived, on average, 24% longer than the controls: 129 vs. 104 weeks. This rivals some of the best life extension results ever achieved in mice.

In the second study glutathione concentration in the old animals was 65% to 72% lower, but GlyNAC supplementation was able to bring the levels back to normal. In all the other key areas, glutathione synthesis, oxidative stress, mitochondrial function, mitophagy, nutrient sensing, and genomic stability, the results were equally impressive: the markers bounced back almost to the levels observed in young mice.

This study might put glutathione, which is already marketed as a supplement, on the list of the most promising life-extending molecules. However, more research is needed to confirm its efficacy in humans. We are not saying that you should start using this, and the standard warnings certainly apply. The results of this study probably warrant the inclusion of glutathione in the Interventions Testing Program, or ITP., which tests various potentially life-prolonging compounds in mice in three different institutions, providing an especially robust testing environment.

As more results come in, we’ll have them for you here, so please subscribe so you don’t miss out.

SOURCES AND FURTHER READING
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Glutathione Extends Lifespan in Mice by 24% - https://www.lifespan.io/news/glutathione-extends-lifespan-in-mice-by-24/

Learn more about Glutathione - https://www.lifespan.io/topic/what-is-glutathione-a-summary-of-glutathione/

GlyNAC Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage - https://www.mdpi.com/2072-6643/14/5/1114/htm

GlyNAC supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial - https://onlinelibrary.wiley.com/doi/10.1002/ctm2.372

GlyNAC in HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial - https://pubmed.ncbi.nlm.nih.gov/33007928/

Interventions Testing Program - https://www.nia.nih.gov/research/dab/interventions-testing-program-itp

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