HER3: Survival Pathway and Therapeutic Target in Colorectal and Pancreatic Cancer | Oncotarget
Channel: Oncotarget
Date: 2023-05-23

Oncotarget published this trending research perspective on May 10, 2023 in Volume 14, entitled, “HER3- A key survival pathway and an emerging therapeutic target in metastatic colorectal cancer and pancreatic ductal adenocarcinoma" by researchers from the Department of Surgery, Case Western Reserve University, Cleveland, OH; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH; Department of Surgery, Division of Surgical Oncology, University Hospitals Cleveland Medical Center, Cleveland, OH. @case 
#cancer  #colorectal  #pancreaticcancer  #cancerresearch  #openaccess  #peerreview  #openscience  #journal  #publication  #research  #perspective  #metastasis 

DOI - https://doi.org/10.18632/oncotarget.28421

Correspondence to - Rui Wang -  rxw517@case.edu

Abstract

Colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) are highly metastatic cancers with poor survival rates. The tumor microenvironment has been shown to play a critical role in cancer progression and response to therapies. Endothelial cells (ECs) are a key component of the tumor microenvironment and promote cancer cell survival by secreting soluble factors that activate cancer-promoting signaling pathways. Studies from us and others identified HER3 as a key mediator of liver EC-induced chemoresistance and cancer cell growth in metastatic CRC and PDAC. In this article, we discuss that HER3-targeted therapies may be effective in treating patients with HER3-expressing CRC and PDAC, and highlight the importance of applying HER3 expression as a predictive biomarker for patient response to HER3-targeted therapies. We also discuss the challenges encountered in past clinical trials of HER3-targeted therapies, including the role of NRG1 gene fusions, alternative HER3 activation mechanisms, and adaptive resistance mechanisms. Finally, we conclude by suggesting the future directions of HER3-targeted therapies, including novel approaches to overcome chemoresistance and promote cancer cell death.

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Keywords - HER3, colorectal, pancreatic cancer, metastasis, microenvironment

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