SDF-1 (biology) | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-03-29

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Stromal_cell-derived_factor_1


00:01:28 1 Structure
00:01:37 1.1 Gene
00:02:02 1.2 Protein
00:03:19 2 Function
00:05:18 2.1 CNS
00:06:57 3 Clinical significance
00:08:13 3.1 Clinical marker
00:09:03 3.2 Multiple Sclerosis
00:09:51 3.3 Alzheimer's Disease
00:11:15 3.4 As a drug target



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SUMMARY
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The stromal cell-derived factor 1 (SDF1), also known as C-X-C motif chemokine 12 (CXCL12), is a chemokine protein that in humans is encoded by the CXCL12 gene on chromosome 10. It is ubiquitously expressed in many tissues and cell types. Stromal cell-derived factors 1-alpha and 1-beta are small cytokines that belong to the chemokine family, members of which activate leukocytes and are often induced by proinflammatory stimuli such as lipopolysaccharide, TNF, or IL1. The chemokines are characterized by the presence of 4 conserved cysteines that form 2 disulfide bonds. They can be classified into 2 subfamilies. In the CC subfamily, the cysteine residues are adjacent to each other. In the CXC subfamily, they are separated by an intervening amino acid. The SDF1 proteins belong to the latter group. CXCL12 signaling has been observed in several cancers. The CXCL12 gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.