PGQu - Prof Dr.  Salvatore Daniele
Channel: Vídeos PGQu - Seminários e Vídeos do Programa de Pós-Graduação em Química da UFRJ
Date: 24/03/2021

Seminário Proferido pelo professor 
Salvatore Daniele , da University Ca’ Foscari Venice sob o tema "Development of electrochemical methods and sensors for the detection of drugs, small molecules and Ag+ ions coming from AgNPs."  para o Programa de Pós-Graduação em Química da da UFRJ (Universidade Federal do Rio de Janeiro)


Resumo: Development of cheap and easy-to-use electrochemical sensors and fast electroanalytical protocols for application in Therapeutic Drug Monitoring (TDM). TDM is the clinical practice devoted to control the concentration of a drug in patient’s body fluids at specific time intervals, in order to control and, eventually, modify the drug dosage, thus improving efficacy of the treatment, while avoiding side effects. Two methods were developed to detect the anticancer drugs Irinotecan and Imatinib in plasma samples. In both cases, the overall procedure included an extraction step from the real matrix, using suitable organic solvents to eliminate interferences due to endogenous compounds  and drugs metabolites. The detection method was performed by using voltammetric techniques, such as differential pulse voltammetry and adsorptive stripping voltammetry. To transfer the methodology to disposables electrode systems, Inkjet Printed Electrodes (IPEs) were investigated.