Nandakumar Jayakrishnan at Masaryk University Life Sciences Seminar Series, May 2022, Czech Republic
Channel: labLifeB
Date: 2022-10-31

Understanding the multiple functions of human telomeres
Life Sciences Seminar Series at Masaryk University  https://muni.cz  Assoc. Prof. Jayakrishnan Nandakumar, Ph.D. from the University of Michigan https://umich.edu/ :
"We study telomeres and telomerase, which are protein-nucleic acid complexes that act on all eukaryotic chromosome ends. Telomeres ensure that our chromosome ends do not engage in illicit inter-chromosomal fusion events that could lead to various diseases including cancer."

Nandakumar Lab https://sites.lsa.umich.edu/nandakumar-lab/

The lecture describes recent progress that the Nandakumar research group has made to understand how human telomerase is recruited to telomeres, how human telomeres attach to the nuclear envelope during meiosis, and how dynein connects to meiotic telomeres and moves them to facilitate meiotic crossover.

Life Sciences Seminar Series at Faculty of Science of Masaryk University https://seminarseries.muni.cz/life-sciences/about-the-series

Telomeres are essential structures at chromosomes that perform three functions. Primarily, telomeres protect chromosome ends from the DNA damage response and repair machinery to prevent illicit chromosome fusion, recombination, and deletion. Additionally, telomeres help replicate the ends of chromosomes in actively dividing cells like stem cells by recruiting the end-replicating enzyme telomerase. Finally, telomeres tether to the nuclear envelope during prophase I of meiosis to connect to the cytosolic dynein machinery and facilitate chromosome movements that are central to homolog pairing and meiotic crossover. Nandakumar's laboratory uses a combination of biochemistry, structural biology, and cell biology to provide molecular insights into the functions of mammalian telomeres.

Hosted by Assoc. Prof. Ctirad Hofr, Ph.D. 
LifeB - Laboratory of interaction and function of essential Biomolecules http://lablifeb.org
Functional Genomics and Proteomics, National Center for Biomolecular Research
Faculty of Science http://sci.muni.cz