mRNA "Wrinkle Vaccine" Boosts Collagen in New Study
Channel: Lifespan News
Date: 2023-02-09

The use of messenger ribonucleic acid, or mRNA, received a lot of attention during the COVID pandemic, but this technology has a lot more potential. In this new study published in the journal Nature, researchers were able to pack mRNA inside extracellular vesicles. The mRNA encoded for a gene that creates collagen called collagen I alpha I. The researchers used something called cellular nanoporation, manipulating an electrical field to create pores in cell membranes, so that the mRNA can get inside the EVs. Then they injected these EVs into aged fibroblasts, which are connective tissue cells that produce collagen proteins. These connective tissues, fibroblasts, started producing way more collagen.

For their in vivo experiments, the researchers used a mouse model of UV-induced skin aging. They pitted their EVs against healthy control mice with no wrinkles and a group that had been treated with lipid-nanoparticles that also had the collagen gene mRNA. Twelve hours after receiving the EV treatment, collagen gene mRNA peaked and had increased significantly, returning to baseline levels after four days. 

Both LNP and EV treatments led to decreases in wrinkle number and area, but the EV group had the biggest change. By day 28, the EV group had as few wrinkles as the healthy mice. LNP and EV treatments both resulted in higher elasticity and firmness.

The researchers also compared the immunogenic side effects of LNPs and EVs. 24 hours after injection, skin treated with LNPs showed redness, swelling, and recruitment of immune cells. But tissue treated with EVs did not exhibit a strong inflammatory reaction, showing that EVs cause much less of an immune response than LNPs.

Unfortunately, wrinkles did reappear about one week later, and about two months after the treatment the wrinkle number and area went back to pre-treatment levels. However, the scientists repeated their experiments and instead of injection, they used microneedle patches treated with EVs. Not only did this method cause wrinkle reduction to last twice as long, it also resulted in more even dispersion of collagen. This proof-of-concept study showed us two things: MRNA delivery through Extracellular Vesicles delivers great results with less side effects, and microneedle application is an effective delivery system. 

SOURCES AND FURTHER READING
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Lifespan News on mRNA for Cancer Treatment - https://youtu.be/6ktxujiRifQ

New Way to Help Aging Cells Produce Collagen - https://www.lifespan.io/news/new-way-to-help-aging-cells-produce-collagen/

Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy - https://www.nature.com/articles/s41551-022-00989-w

Lipid nanoparticles for mRNA delivery - https://www.nature.com/articles/s41578-021-00358-0

Extracellular Vesicles Commercial Potential As Byproducts of Cell Manufacturing for Research and Therapeutic Use - https://bioprocessintl.com/manufacturing/cell-therapies/extracellular-vesicles-commercial-potential-as-byproducts-of-cell-manufacturing-for-research-and-therapeutic-use/

Every Moment is Vital | Vital Proteins® & Jennifer Aniston™ - https://www.youtube.com/watch?v=C-BVPnK9IOI

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