New Hallmarks of Ageing 2022 Meeting Summary | Aging
Channel: Aging (Aging-US)
Date: 2022-09-13

Aging-US published this trending review in Volume 14, Issue 16, entitled, "New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary" by researchers from the Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog 1478, Norway; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow 30-348, Poland; Center for Healthy Ageing, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2400, Denmark; Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital – Bispebjerg and Frederiksberg, Copenhagen 2400, Denmark; Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, Lund, Sweden; Stem Cell Laboratory, UCL Cancer Institute, University College London, London, UK; Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital Rigshospitalet, Glostrup 2600, Denmark; The David and Inez Myers Laboratory of Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Tel Aviv University School of Medicine P.O.B 39040, Tel Aviv, Israel; Department of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA; Department of Functional Genomics and Cancer, IGBMC, CNRS/INSERM/University of Strasbourg, Equipe labellisée Ligue contre le Cancer, Strasbourg, France; College of Medicine, Center for Genomics and Precision Medicine, National Taiwan University, Taipei City, Taiwan; UK National Innovation Centre for Ageing, The Catalyst, 3 Science Square, Newcastle University, Newcastle upon Tyne, NE4 5TG, UK; Buck Institute for Research on Ageing, Novato, CA; Section on DNA Repair, National Institute on Ageing, Baltimore, MD; Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK; Department of Molecular Biology and Genetics, Aarhus University, Aarhus 8000, Denmark; The Norwegian Centre on Healthy Ageing (NO-Age), Oslo, Norway; UPMC Hillman Cancer Center, Pittsburgh, PA. 
#openaccess #meeting #aging #science #peerreview

DOI - https://doi.org/10.18632/aging.204248

Corresponding authors - Tinna Stevnsner - tvs@mbg.au.dk, Lene Juel Rasmussen - lenera@sund.ku.dk, Evandro F. Fang - e.f.fang@medisin.uio.no

Abstract

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion, and altered intercellular communication were the original nine hallmarks of ageing proposed by López-Otín and colleagues in 2013. The proposal of these hallmarks of ageing has been instrumental in guiding and pushing forward research on the biology of ageing. In the nearly past 10 years, our in-depth exploration on ageing research has enabled us to formulate new hallmarks of ageing which are compromised autophagy, microbiome disturbance, altered mechanical properties, splicing dysregulation, and inflammation, among other emerging ones. Amalgamation of the ‘old’ and ‘new’ hallmarks of ageing may provide a more comprehensive explanation of ageing and age-related diseases, shedding light on interventional and therapeutic studies to achieve healthy, happy, and productive lives in the elderly.

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Keywords - aging, hallmarks of ageing, neurodegeneration, healthspan, longevity, autophagy

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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