Diethylstilbestrol | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-12-07

This is an audio version of the Wikipedia Article:
Diethylstilbestrol


00:02:14 1 Medical uses
00:03:55 2 Side effects
00:05:16 2.1 Long-term effects
00:05:47 3 Overdose
00:06:05 4 Pharmacology
00:06:14 4.1 Pharmacodynamics
00:06:23 4.1.1 Estrogenic activity
00:08:18 4.1.2 Antigonadotropic effects
00:08:52 4.1.3 Other activities
00:10:23 4.2 Pharmacokinetics
00:11:36 5 Chemistry
00:12:27 6 History
00:12:36 6.1 Synthesis
00:13:28 6.2 Clinical use
00:19:54 6.3 Lawsuits
00:20:57 7 Society and culture
00:21:27 8 Veterinary use
00:21:37 8.1 Canine incontinence
00:22:08 8.2 Livestock growth promotion



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SUMMARY
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Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is an estrogen medication which is mostly no longer used. In the past, it was widely used for a variety of indications including pregnancy support for women with a history of recurrent miscarriage, hormone therapy for menopausal symptoms and estrogen deficiency in women, treatment of prostate cancer in men and breast cancer in women, and other uses. While most commonly taken by mouth, DES was available for use by other routes as well, for instance vaginal, topical, and by injection.
DES is an estrogen, or an agonist of the estrogen receptors, the biological target of estrogens like estradiol. It is a synthetic and nonsteroidal estrogen of the stilbestrol group, and differs from the natural estrogen estradiol in various ways. Compared to estradiol, DES has greatly improved bioavailability when taken by mouth, is more resistant to metabolism, and shows relatively increased effects in certain parts of the body like the liver and uterus. These differences result in DES having an increased risk of blood clots, cardiovascular issues, and certain other adverse effects.DES was discovered in 1938. From about 1940 to 1971, the medication was given to pregnant women in the incorrect belief it would reduce the risk of pregnancy complications and losses. In 1971, DES was shown to cause clear cell carcinoma, a rare vaginal tumor, in girls and women who had been exposed to this medication in utero. The United States Food and Drug Administration subsequently withdrew approval of DES as a treatment for pregnant women. Follow-up studies have indicated that DES also has the potential to cause a variety of significant adverse medical complications during the lifetimes of those exposed.The United States National Cancer Institute recommends women born to mothers who took DES undergo special medical exams on a regular basis to screen for complications as a result of the medication. Individuals who were exposed to DES during their mothers' pregnancies are commonly referred to as "DES daughters" and "DES sons". Since the discovery of the toxic effects of DES, it has largely been discontinued and is now mostly no longer marketed.