Imaging synaptic transmission in the brain
Channel: Research Outreach
Date: 2022-08-02

With the help of cryo-electron tomography, Dr Lučić proposes a structural neurotransmitter release model that gives insight into how the human brain processes information.
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Article
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https://researchoutreach.org/articles/cryo-electron-tomography-synaptic-transmission-brain/
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References
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Martinez-Sanchez, A., Kochovski, Z., Laugks, U. et al. (2020). Template-free detection and classification of membrane-bound complexes in cryo-electron tomograms. Nat Methods, 17, 209–216. https://doi.org/10.1038/s41592-019-0675-5

Zuber, B., Lučić, V. (2019). Molecular architecture of the presynaptic terminal.
Current Opinion in Structural Biology, 54, 129–138. https://doi.org/10.1016/j.sbi.2019.01.008

Schrod, N., Vanhecke, D., Laugks, U., Stein, V., Fukuda, Y., Schaffer, M., Baumeister, W. and Lučić, V. (2018) Pleomorphic Linkers as Ubiquitous Structural Organizers of Vesicles in Axons. PLoS ONE, 13, e0197886. https://doi.org/10.1371/journal.pone.0197886

Fernández-Busnadiego, R., Asano, S., Oprisoreanu, A-M., Sakata, E., Doengi, M., Kochovski, Z., Zürner, M., Stein, V., Schoch, S., Baumeister, W., and Lučić, V. (2013). Cryo–electron tomography reveals a critical role of RIM1α in synaptic vesicle tethering. The Journal of Cell Biology, 201, 725–740. https://doi.org/10.1083/jcb.201206063

Fernández-Busnadiego, R., Zuber, B., Maurer, U.E., Cyrklaff, M., Baumeister, W., and Lučić, V. (2010). Quantitative analysis of the native presynaptic cytomatrix by cryoelectron tomography. The Journal of Cell Biology, 188(1), 145-156. https://www.doi.org/10.1083/jcb.200908082
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#synaptic
#imageprocessing
#synapticstructure
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