Resveratrol Controversy Update! Drs. Stanfield & Brenner Respond
Channel: Lifespan News
Date: 2022-03-04

In the last episode, we discussed a controversy surrounding resveratrol, and now we’ll update you on the reaction to that video from Drs. Stanfield & Brenner and what we can do going forward.

Resveratrol is used by many people for what they believe are it’s health and longevity benefits, and much of this belief stems from studies that were conducted by Dr. David Sinclair and his team at Harvard University in the mid-2000s. Since then the results of these studies have been called into question - with the argument being that resveratrol is incapable of activating sirtuin-1 in humans, that there’s no reliable data for it’s benefits, and that it might not only be ineffective, but could actually be harmful to humans. Dr. Sinclair seems to disagree, and stands by his research. That’s a quick summary of the situation. For more on the background, please watch our previous video on this topic, and check out the source material linked in that video description.

The purpose of our previous video, and the reason we addressed this topic at all, was to find alignment on what should be the mutual goals of everyone involved - to attain and share knowledge about how to extend healthy human lifespan, and to work to make sure that those methods are made available so that they can help people.

Once we all agree on that mission, which should not be difficult, what to do about resveratrol becomes clear - let’s have the leading scientists and experts on both sides of this issue discuss their areas of disagreement directly, come to a consensus on what evidence or data would settle their disagreements, and then gather that data. Lifespan.io, the non-profit organization behind Lifespan News, offered to facilitate this discussion, and to work to help fund the study that could provide resolution to this. But it doesn’t need to be us - We’d support the efforts of others to do this, as well.

I have not seen any public response to this from Dr. Sinclair. Dr. Sinclair could have any number of reasons for not wanting to engage here. A lot of people may jump to the assumption that demonstrated unwillingness to engage on these topics is proof that his position is indefensible. I’m not willing to assume that, though I understand why many do. There could be any number of explanations, including business interests, legal advice, confidentiality, or even just because he doesn’t take these claims - or perhaps those that are most vocal in making them - seriously, and perhaps thinks there could be other motives at play.

Unfortunately, without a recognized expert who is able and willing to publicly defend the position that resveratrol does activate SIRT-1 in humans, or at a minimum does provide health and/or longevity benefits in humans, I don’t see how this debate or discussion that we’ve been advocating for can take place.

Without any noteworthy developments, this may be as far as we at Lifespan News can go towards addressing the disagreements surrounding resveratrol.

SOURCES AND FURTHER READING
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Our Previous Video on this Topic - https://youtu.be/eBxw6_8PivA

Dr. Brad Stanfield LSN Response - https://twitter.com/BradStanfieldMD/status/1495477959255523328

Dr. Charles Brenner LSN Response - https://twitter.com/CharlesMBrenner/status/1495461335508918274

Dr. Jeffrey Flier LSN Response - https://twitter.com/jflier/status/1495476157759770625

AgingDoc Tweet to Sinclair - https://twitter.com/agingdoc1/status/1496235492781826051

Modulation of SIRT1 expression improves erectile function in aged rats - https://www.ajandrology.com/preprintarticle.asp?id=337880

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#Resveratrol #DavidSinclair #LifeExtension #Longevity

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