The library in your cells
Channel: Lifespan News
Date: 2021-01-21

Stress and diet leave their mark on your DNA, affecting how genes are expressed as you age. Let's talk about histones, a sort of microscopic books in your cells whose readability is changes with aging.

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SOURCES AND FURTHER READING
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Dang W, Steffen KK, Perry R, Dorsey JA, Johnson FB, Shilatifard A, Kaeberlein M, Kennedy BK, Berger SL. (2009) Histone H4 lysine 16 acetylation regulates cellular lifespan. Nature 459, 802-807. doi: 10.1038/nature08085

Greer EL, Maures TJ, Hauswirth AG, Green EM, Leeman DS, Maro GS, Han S, Banko MR, Gozani O, Brunet A. (2010) Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature 466, 383-387. doi: 10.1038/nature09195

Krishnan V, Chow MZY, Wang Z, Zhang L, Liu B, Liu X, Zhou Z. (2011) Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice. PNAS 108, 12325-12330. doi: 10.1073/pnas.1102789108

Molina-Serrano D, Kyriakou D, Kirmizis A. (2019) Histone Modifications as an Intersection Between Diet and Longevity. Frontiers in Genetics 10, 192. doi: 10.3389/fgene.2019.00192

Oh, S, Suganuma T, Gogol MM, Workman JL. (2018) Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response. eLife 7, e36157. doi: 10.7554/eLife.36157

Zhou L, He B, Deng J, Pang S, Tang H. (2019) Histone acetylation promotes long-lasting defense responses and longevity following early life heat stress. PLoS Genetics 15(4): e1008122. doi: 10.1371/journal.pgen.1008122

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#DNA #Aging #histones #epigenetics #methylation #acetylation #phosphorylation #LifeExtension #MolecularBiology