DIGITAL REIMAGINATION ( DIGI-Ri )👉 Insilico’s AI Tackles Lysosomal Storage Disorder👉Generative AI
Channel: ARTHASACHI VENTURE
Date: 2023-07-23

DIGITAL REIMAGINATION ( DIGI-Ri ) 👉 INSILICO MEDICINE 

Insilico Medicine has initiated human trials for a pharmaceutical agent engendered through artificial intelligence, marking a momentous stride in the realm of generative AI within drug development. This pioneering biotechnological enterprise, underpinned by support from the esteemed Chinese conglomerate Fosun Group and the private equity titan Warburg Pincus, has commenced one of the earliest mid-stage clinical assessments of an AI-discovered and AI-designed therapeutic compound.

Founded by the erudite scientist hailing from Latvia, Alex Zhavoronkov, Insilico Medicine has administered the novel drug, INS018_055, to a patient in China with the purpose of treating the enduring pulmonary ailment known as idiopathic pulmonary fibrosis. This groundbreaking pharmaceutical, having traversed the preliminary stages of development, now embarks on its phase 2 clinical trial, signifying a pivotal achievement within the domain.

In the past week, two announcements from the drug discovery world have had Insilico Medicine’s generative artificial intelligence (AI) target discovery engine, PandaOmics, front and center.

The first involved the use of PandaOmics to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease. This was work done by the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich. The research collaboration between Insilico and MIKADO was first announced in March 2022.

These results, which open new therapeutic possibilities for this disease, were published in Nature Communications in the article, “Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization.”

Video Source: Insilico Medicine

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