ADHD Medications Don't Work? Check Duration of Effectiveness
Channel: Dr Charles Parker
Date: 2012-11-22

NB: Most Recent *excellent article* on Dosage Strategy and Treatment Outcomes: Molecular Psychiatry: Farhat et al:  https://doi.org/10.1038/s41380-021-01391-9
- Shortcode for this specific useful Vid playlist: http://corepsych.com/dose

Dr. Parker’s book "New ADHD Medication Rules: Brain Science & Common Sense"  is available anywhere in the world, by clicking on this link:  http://geni.us/adhd

#ADHD Medications PDF Video Cheat Sheet: Med Details in Video and Audio - http://corepsych.com/details 

1:06 http://corepsych.com/connect - More than 460 articles on psychiatric diagnosis and treatment.

*GI Transit Time Tool - Mayo* = Download PDF: http://www.corepsych.com/ttt
Video Playlists For More Info on ADHD Med Details:
ADHD Diagnosis Evolves: Vid Playlist: http://corepsych.com/diagnosis
ADHD Meds Tutorial: -- Overview: http://bit.ly/medstutorial 
ADHD Meds Dosage: Repeat plug! - http://corepsych.com/dose 
ADHD Meds Problems -- Mind and Gut: http://bit.ly/mindgut 
ADHD Meds & Allergies -- Milk and Wheat: http://bit.ly/mawimmun
ADHD Meds & Allergies -- Street Immunity: http://bit.ly/IorWJs  

To see the connection between brain science and common sense: evidence matters.

Details Matter: 
The Meds Don't Work Long Enough: The Duration of Effectiveness [DOE] is not adequate: Each stimulant drug, each family of stimulant drugs has its own expected DOE. This DOE is not discussed in the literature as a measuring tool, but it's common knowledge to any who watch carefully for drug action and duration throughout the day - but often not discussed effectively in med checks - as I have discovered on second opinions many times. 

All stimulant medications have an expected, *less than 24 hr duration.* This is an obvious point but is overlooked so often as an essential measurement tool. If meds last less than 24 hr, then how long should each last? Dialing in a specific duration is essential to get the best action out of each specific med. [AMP=Amphetamine Family, MPH=Methylphenidate Family]

- Vyvanse [AMP] and Daytrana [MPH patch] both top the DOE expectations with 10-12 hr targets.
- Adderall XR [AMP] is next with 8-10 hr DOE, often better at 8 hr.
- Concerta LA [MPH] and Focalin [MPH] both run 8 hr if dialed in effectively - some studies show longer, in my experience: more than 10 hr with either of these is too much -- see other articles on the 'Top of the Window'
- Metadate CR [MPH] and Ritalin LA [MPH] are both right at 8 hr, rarely longer, with side effects, if pushing the dose higher

The *Immediate Release* Stimulants, the tablets with no extended time
expected, last only a portion of the day with 
- Adderall IR [AMP] [Immediate Release Tabs] lasting about 4 hr, 
- Ritalin IR [MPH] is a 4-hour max duration.

Please *Like* this and share it with your friends - accurate DOE makes a difference.

http://youtu.be/rmuCkCRFUQM