Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle Ca2
Channel: NeuroMat
Date: 2020-05-20

The webinar "Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle-Ca2+ channel distances" was given by Susanne Ditlevsen, from the Department of Mathematical Sciences of the University of Copenhagen.

In this presentation, she discusses that postulated facilitation mechanisms operating via activity-dependent changes of vesicular release probability (e.g. by a facilitation fusion sensor) generate too little facilitation and too much variance. In contrast, Ca2+-dependent mechanisms rapidly increasing the number of releasable vesicles reliably reproduce short-term plasticity and variance of synaptic responses. Susanne proposes activity-dependent inhibition of vesicle un-priming or release site activation as novel facilitation mechanisms.

Find other details about this seminar and the others in the series here: 
https://neuromat.numec.prp.usp.br/content/nmweb/