hackseqRNA Team Presentation: Project 9:Modelling potential RNA
Channel: hackseq Collective
Date: 2020-05-24

Project description 

Can we use the SARS-CoV-2 transcriptome to predict host and virus RNA:RNA interactions based on RNA secondary structure and accessibility profiles using Vienna or some other method?

RNA:RNA interactions are emerging as important in pathogenesis, yet this remains unexplored for novel SARS-CoV-2. Since the SARS-CoV2 transcriptome is available, I propose modeling potential RNA:RNA interactions using both accessibility profile and predicted secondary structure of the SARS-CoV-2 transcriptome. The main objective is to identify any novel pathogenic mechanisms, which may serve as potential targets for therapeutics. The output will be visualization of the most robust network of host-virus RNA:RNA interactions, plus possibly a pre-print or article and open-accesssqu tool available for other researchers.