Biological clock (aging) | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-03-28

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Epigenetic_clock


00:00:13 1 History
00:02:18 2 Relationship to a cause of biological aging
00:03:13 2.1 Epigenetic clock theory of aging
00:04:18 3 Motivation for biological clocks
00:05:34 4 Properties of Horvath's clock
00:07:30 4.1 Statistical approach
00:08:57 4.2 Accuracy
00:09:53 4.3 Comparison with other biological clocks
00:11:13 5 Applications of Horvath's clock
00:12:05 5.1 Genetic studies of epigenetic age acceleration
00:13:20 5.2 Lifestyle factors
00:13:57 5.3 Obesity and metabolic syndrome
00:15:11 5.4 Female breast tissue is older than expected
00:16:02 5.5 Cancer tissue
00:17:34 5.6 Trisomy 21 (Down syndrome)
00:18:18 5.7 Alzheimer's disease related neuropathology
00:19:06 5.8 Cerebellum ages slowly
00:20:09 5.9 Huntington's disease
00:20:27 5.10 Centenarians age slowly
00:21:00 5.11 HIV infection
00:22:01 5.12 Parkinson's disease
00:22:22 5.13 Developmental disorder: syndrome X
00:23:01 5.14 Menopause accelerates epigenetic aging
00:24:05 5.15 Cellular senescence versus epigenetic aging
00:27:07 5.16 Effect of sex and race/ethnicity
00:27:54 5.17 Rejuvenation effect due to stem cell transplantation in blood
00:28:38 5.18 Progeria
00:29:04 6 Biological mechanism behind the epigenetic clock
00:29:48 6.1 Possible explanation 1: Epigenomic maintenance system
00:30:10 6.2 Possible explanation 2: Unrepaired DNA damages
00:31:28 7 Other age estimators based on DNA methylation levels
00:36:19 7.1 Other species



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SUMMARY
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Epigenetic clock is a term used to describe a biochemical test that can be used to measure age. The test is based on DNA methylation levels.