"Specific" interaction networks #shorts
Channel: Lars Juhl Jensen
Date: 2023-04-11

Many both database resources and scientific papers produce protein interaction networks that describe as either tissue specific or disease specific. These networks are almost universally created by taking a global network, such as STRING, and filtering it by removing the proteins that are not expressed in a given tissue or disease. The positive view is, that these networks are useful, since querying them for a protein will yield likely interactors in the tissue or disease of interest. the negative view is, that it is misleading to call these networks "specific", since they are filtered global networks, not networks with tissue- or disease-specific interaction evidence.