Julie Campbell (vascular biologist) | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-05-02

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Julie_Campbell_(vascular_biologist)


00:02:05 1 Early history
00:03:29 2 Family history
00:05:00 3 Career
00:07:06 3.1 Current projects
00:08:10 4 Recognition for achievements
00:09:09 5 Present positions
00:10:10 6 Awards
00:10:35 7 Publications



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SUMMARY
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Julie Hazel Campbell (born 2 November 1946) is an Australian vascular biologist; and she was born in Sydney, Australia. Campbell, cell biologist and professorial fellow at the Australian Institute for Bioengineering and Nanotechnology, is recognized as a world leader in the field of smooth muscle biology. In the early 1970s, she was the first to discover that smooth muscle cells can exist in a spectrum of phenotypes that control the cell’s biology and response to disease stimuli (e.g. in heart diseases). She further determined how these cells could be maintained in the ‘non-disease’ phenotype. This knowledge helped modern scientist’s understanding of how atherosclerotic plaques form and provided information on potential strategies for prevention.
Campbell was the first to discover that cells of bone marrow origin contribute to intimal (the innermost coat of blood vessels) thickening in arteries subjected to injury, rather than solely from cells of the artery wall. This showed that current strategies to prevent restenosis after angioplasty of blocked arteries may have been targeting the incorrect cell type.
Her most recent work involves the development of autologous vascular grafts from cells of bone marrow, known as the myeloid, origin using the abdominal cavity as a bioreactor. These tissue-engineered ‘artificial arteries’ have potential use as access fistulae for haemodialysis patients and as coronary artery bypass grafts. She has used the same technology to grow bladder and uterine graft with long-term viability. These discoveries have been protected by international patents.She has other research that involves basic cellular interactions in the artery wall, and the definition of single transduction pathways through which factors act to enhance vascular disease regression and prevent disease development/progression.