MINE (chemotherapy) | Wikipedia audio article
Channel: wikipedia tts
Date: 06/06/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/MINE_(chemotherapy)





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SUMMARY
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MINE in the context of chemotherapy is an acronym for one of the chemotherapy regimens used for treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma and Hodgkin's lymphoma.
Today this regimen is often combined with monoclonal antibody rituximab. In this case the regimen is called R-MINE or MINE-R.
The [R]-MINE regimen consists of:

(R)ituximab - anti-CD20 monoclonal antibody that can kill both normal CD20-expressing B cells and malignant ones;
(M)esna to prevent the development of hemorrhagic cystitis which may otherwise result from ifosfamide administration;
(I)fosfamide - an alkylating antineoplastic agent from oxazafosforine group;
(N)ovantrone - a synthetic antracycline analogue (antraquinone) that is able to intercalate DNA and thus prevent cell division (mitosis);
(E)toposide - a topoisomerase inhibitor.