Triphosphorylating Reagent Preparative Procedure
Channel: ccclabmit
Date: 2019-09-28

This is the procedure to prepare [PPN][P3O8(OP(NC4H8)3)].2H2O, a triphosphorylating reagent for C, N, and O nucleophiles as described in J. Am. Chem. Soc. 2019, 141, 1852-1856 (DOI: 10.1021/jacs.8b12204) by Shepard and Cummins. The compound is an activated form of trimetaphosphate, here prepared and isolated easily on the benchtop on a multi-gram scale.