How Can Metformin Impact Lifespan & Healthspan?
Channel: InsideTracker
Date: 2024-03-22

How can metformin impact lifespan & healthspan?

This clip is from a full episode of Longevity by Design. Hosts Dr. Gil Blander and Ashley Reaver, MS, RD, CSSD,  interview Dr. Nir Barzilai—the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging—during which he discusses groundbreaking research on aging. 

In the full interview, they discuss: 

Introduction: 00:00-04:13
Why Dr. Barzilai’s studies centenarians and their children
Do centenarians live longer with poor health or live healthier longer?
Does becoming a centenarian have a strong genetic influence?: 
How do growth hormone and IGF-1 affect healthspan and lifespan?:
What other genes affect healthspan and lifespan?
Does low IGF-1 negatively impact muscle and physical function?: 
What are the effects of ethnicity and socioeconomic status on longevity?
What is the effect of lifestyle, nutrition, and exercise on the longevity of centenarians?
Do women or men live longer?
Why do women live longer than men?
Biomarkers of aging and biomarkers of organ aging
What is metformin, and what is the purpose of the TAME trial?:
Do you think metformin will improve healthspan and lifespan?
Does metformin only improve blood glucose control, or does it benefit health and aging in other ways? 
Is metformin good for older adults but not young adults?
How does the combination of metformin and exercise impact muscle size (hypertrophy) and strength?
Should everyone take metformin?
Are GLP-1 agonists beneficial for healthspan and lifespan?
Are there tradeoffs with using GLP-1 agonists?
What are the top 5 gerotherapeutic candidates for improving healthspan and lifespan?
Dr. Nir Barzilai’s top tip for improving health

Tune in to the full episode: https://www.youtube.com/watch?v=C2OssxD6AMY
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