Prozac, Paxil & Drug Interactions With Amphetamines for ADHD - Dr. Charles Parker
Channel: Dr Charles Parker
Date: 2012-09-16

Please don't ask here about specific drug interactions - learn about them. Review these numerous references [two links with multiple references, a video playlist, and books], and then also review the many comments here. ! Playlist on 2D6 here: http://corepsych.com/2d6 - Share the references and book links with your medical providers if they dispute this data. And remember the importance of genetic changes in CYP450-2D6 metabolic pathways that also contribute to unpredictability beyond drug interactions. If you take stimulants or write for stimulant medications these observations will prevent considerable difficulties. Again, the entire vid playlist on 2D6 with references in the description: http://corepsych.com/2d6

For drug interaction details take the next important step of bookmarking these two URLs: 
- http://healthtools.aarp.org/drug-interactions  
- and the Mayo Clinic PDF link on 2D6: http://www.corepsych.com/2d6-mayo
- and this 2D6 Video Playlist of 11 informative YouTube videos: http://corepsych.com/2d6
- and this milestone book - Amazon: Drug Interaction Principles in Medical Practice: 
http://corepsych.com/interaction-book
- and Stahl's Book: The Prescriber's Guide - Psychopharmacology: http://corepsych.com/stahl 

This Prozac and Paxil interaction has lived on my clinical practice radar since '96 - and is *the most frequently denied [and corrected] drug interaction* in my many thousands of second opinions since then. Read the literature linked here in these notes - this is not a radical opinion but a proven fact, and present in every Prozac package insert. Take a good look. And then ask Dr. Stephen Stahl, internationally recognized psychopharmacologist and author, teaching at UCSD, who started this conversation for me back in '96. Stahl's book is strongly recommended: The Prescriber's Guide to Psychopharmacology: http://corepsych.com/stahl 

*Preview these CoreBrain Academy ADHD Coursework* details:
- ADHD101 - +55 lessons & coaching: How to measure, target , & treat brain/biomedical realities  https://www.corebrainacademy.com/courses/adhd-treatment-failure
- The PM Drop - ADHD Minicourse: Learn how to use the most common problems to correct Treatment Failure results & comorbid conditions not initially recognized.
https://www.corebrainacademy.com/courses/pm-drop
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For excellent Expert Commentary on Executive Function challenges from diagnosis and treatment to parenting: http://corebrainjournal.com/family
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For Genetic remarks that contribute to unpredictable outcomes: 
https://selfhacked.com/blog/cyp2d6
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Parker’s book "New ADHD Medication Rules"  is available globally here:  http://geni.us/adhd
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For CoreBrain Journal Podcast details on the evolution of precise neuroscientific thinking: http://corebrainjournal.com/mission

*How To Start ADHD Meds* PDF for patients - download: http://corepsych.com/feedback 

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For a PDF Collection of Video Details from ADHD Drug Interactions to ADHD Treatment Failure: http://corepsych.com/details 

Remember this: Prozac and Paxil both significantly block the 2D6 pathway for the metabolism of Adderall, Vyvanse, and all the amphetamine [AMP] products. If you take either of these two antidepressants together with an amphetamine, watch out. You can significantly become overdosed on the amphetamine and behave as *Bipolar.* Often the interaction can unpredictably occur several months later. The patient becomes toxic to the amphetamine, angry, irrational, can't sleep, can't eat, and can become dangerously destructive, even suicidal. The Adderall or Vyvanse often gets blamed. Those with a seriously *genetically compromised* CYP-2D6 will react poorly much sooner. 

More details on the importance of 2D6, Prozac, Paxil, metabolism, and customized dosing strategies in my book, eBook and Audible: "New ADHD Medication Rules" here: http://geni.us/adhd
To see the connection between brain science and common sense: details matter, evidence matters.

See this post from 2006: http://www.corepsychblog.com/2006/11/adderall-prozac-and-paxil-problem-not-solution/

CorePsych Post from 2008: http://www.corepsych.com/2008/12/add-adhd-medications-amphetamines-2d6-drug-interaction-update

My article on these matters in Primary Psychiatry, with my son as coauthor: 
http://www.primarypsychiatry.com/aspx/articledetail.aspx?articleid=327 
- Many years ago when my son was a medical student he also became interested in this subject.

This video link: http://youtu.be/xB5dZd1ucdE