Myasthenia Gravis by Dr Padma Gunaratne
Channel: ASN Neurology
Date: 2021-08-01

Webinar 22 - 10 Pearls Series

Webinar series conducted by the Association of Sri Lankan Neurologists targeted at the Medical Officers, Medical Registrars, General Physicians, Family Physicians and Medical Students. A journey of 32 neurology topics, each with 10 pearls.

The twenty-second lecture in the series, Myasthenia Gravis is delivered by Dr Padma Gunaratne. She is a past-president of the Association of Sri Lankan Neurologists. .

10 Pearls of this lecture
1. MG is caused by antibody mediated, T cell dependent complement mediated attack on the post synaptic membrane.
2. MG is a disease of skeletal muscles and it is spared of sensory and autonomic manifestations.
3. Variable weakness of MG lead to the misdiagnosis with psychogenic weakness.
4. Ice pack, edrophonium chloride test, neurophysiology and serology are useful for confirmation of the diagnosis.
5. MG could effectively be treated with immunosuppression with corticosteroids, azathioprine, MMF
6. IV IG, plasma exchange and assisted ventilation are used for management of crisis situations
7. Thymectomy is proven to improve clinical outcome in patients with generalized MG
8. Myasthenic crisis could be precipitated by some medications, surgery, infections, pregnancy and stress
9. Special consideration should be given to women in childbearing age and pregnant women
10. Mortality of MG is remarkably low with the availability of mechanical ventilation and intensive care for Myasthenic crisis and the increased options available for immunomodulation therapy.

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