Sex and drugs: my rock and roll by Professor Amrita Ahluwalia, Stephen Paget Lecture 2023
Channel: Understanding Animal Research
Date: 2024-01-11

The Stephen Paget Memorial Lecture celebrates the life of Stephen Paget who passionately believed that a greater understanding of physiology would lead to better medical advances. He was the founder of the Research Defence Society which later became Understanding Animal Research. 

This year Professor Amrita Ahluwalia presented the 86th Paget Lecture, with her talk "Sex and drugs: my rock and roll". Professor Amrita Ahluwalia is Dean for Research in the Faculty of Medicine and Dentistry at the Barts and London School of Medicine and Dentistry, Director of the UKCRC-accredited Barts Cardiovascular Clinical Trials Unit, and Professor of Vascular Pharmacology at Queen Mary University of London where she is a Principal Investigator leading the Vascular Pharmacology Group.


Chapters:

00:00 Introduction
03:12 Stephen Paget
09:10 CVD in the UK
13:35 Hypertension
14:48 Sex differences in BP
16:26 BP factors
17:36 Endothelial mediators
22:21 The EDHF Mouse
28:21 Females and EDHF
29:50 Vascular homeostasis 
30:27 Inflammatory responses in mice
32:22 Leukocyte-endothelial cell interactions
38:00 Sex differences in inflammatory responses in humans
38:53 Cantharidin-induced blisters model
43:00 Systemic inflammation induced vascular dysfunction model
45:01 Typhoid vaccine
48:34 Sex-bias in research- what are the issues?
50:46 Pharmacological research sex bias
55:24 Sex as an experimental variable editorial
59:13 Sex bias workshop 
01:00:47 The research community is waking up 
01:04:22 Questions from the audience

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