Biophysical Chemistry 2018 - Lecture 11
Channel: Erik Lindahl
Date: 2018-04-16

Kinetics of protein folding. More about Chevron plots, and how to use them to find the change of the transition state barrier vs. stability of the folded state - expressed as phi-values. Identification of transition states. The influence of energy of states, and how their relative stability can give rise to misfolding. The variation of enthalpy & entropy, as explained by the Nucleation-Condensation folding model - and the solution to Levinthal's paradox.