RNA Polymerase
Channel: RandomGrlxD
Date: 2011-11-13

(Chorus) 
RNA Polymerase is essential to the central dogma
And the fact that it's so damn important is no no no enigma
RNA Polymerase is an enzyme found in all organisms
Making mRNA, tRNA and rRNA is its main mechanism
What else does it do? It carries out transcription
You wanna know more? Well here's a description

RNA polymerase uses one strand of DNA as a template
Which guides the synthesis of a new strand at a fast rate
It produces an RNA chain that is complementary to DNA
What does that mean? It means nucleotide C to G U to A
It can also build an RNA chain as 2.4 million nucleotides long
And don't you worry, this isn't close to the end of our song
The three steps to transcription are initiation, elongation and termination
WHAT ARE THE THREE STEPS SHARON?
INITIATION ELONGATION AND TERMINATION!
Ha, HA the promoter is a DNA sequence 
Where RNAP attaches and initiation commences  
During elongation RNAP adds nucleotides from the 5'-3' end
And transcription progresses at a rate of 60 nucleotides per second!

In prokaryotes, termination is signaled by the terminator 
It's like the end when you meet Arnold Schwarzenegger  
In eukaryotes, termination is different, let me explain 
This is because pre-mRNA is cleaved from the RNA chain 

(Chorus) 
RNA Polymerase is essential to the central dogma
And the fact that it's so damn important is no no no enigma
RNA Polymerase is an enzyme found in all organisms
Making mRNA, tRNA and rRNA is its main mechanism
What else does it do? It carries out transcription
You wanna know more? Well here's a description

2 large and 5-12 smaller subunits is RNAP's configuration
We know our information so please stop with the accusation 
In eukaryotes there are 3 different types, RNAP III, II and I
RNAP I synthesizes rRNA which forms the ribosome but I'm not done 
RNAP II synthesizes mRNA which directs the making of a protein
RNAP III synthesizes tRNA which brings the amino acids for the protein

The cell nucleus is where transcription occurs for eukaryotes 
The cytoplasm is where transcription occurs for prokaryotes 
There is only one type of Bacterial RNAP which is made up of 5 subunits 
It synthesizes mRNA and other types of RNA that function in protein synthesis
Initiation starts when RNAP recognizes and binds to the promoter in prokaryotes 
Transcription factors are proteins needed for initiation in eukaryotes

(Chorus) 
RNA Polymerase is essential to the central dogma
The fact that it's so damn important is no no no enigma
RNA Polymerase is an enzyme found in all organisms
Making mRNA, tRNA and rRNA is its mechanism
And now you know everything about RNA Polymerase
So you better not fail your test and put us in disgrace