Is Your Body Older Than You Are? (X10 on epigenetic clocks)
Channel: Lifespan News
Date: 24/06/2021

Your age can be different from the age of your body. That's right, your body can be older (or younger) than you are, depending on a number of factors. It's called epigenetic age, and it can be measured by tools called epigenetic clocks. But what do they really measure? How reliable are they? Can they tell you how long you are going to live? Let's find out.

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SOURCES AND FURTHER READING
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Bell, C.G., Lowe, R., Adams, P.D., Baccarelli, A.A., Beck, S., Bell, J.T., Christensen, B.C., Gladyshev, V.N., Heijmans, B.T., Horvath, S., Ideker, T., Issa, J-P.J., Kelsey, K.T., Marioni, R.E., Reik, W., Relton, C.L., Schalkwyk, L.C., Teschendorff, A.E., Wagner, W., Zhang, K., and Rakyan, V.K. (2019) DNA methylation aging clocks: challenges and recommendations. Genome Biology doi: 10.1186/s13059-019-1824-y

Fransquet, P.D., Wrigglesworth, J., Woods, R.L., Ernst, M.E., and Ryan, J. (2019) The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis. Clinical Epigenetics doi: 10.1186/s13148-019-0656-7

Hannum, G., Guinney, J., Zhang, L., Hughes, G., Sadda, S., Klotzle, B., Bibkova, M., Fan, J-B., Gau, Y., Deconde, R., Chen, M., Rajapakse, I., Friend, S., Ideker, T., and Zhang, K. (2013) Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates. Molecular. Cell doi: 10.1016/j.molcel.2012.10.016

Horvath, S. (2013) DNA methylation age of human tissues and cell types. Genome Biology doi: 10.1186/gb-2013-14-10-r115

Horvath, S and Raj, K. (2018) DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nature Reviews Genetics doi: 10.1038/s41576-018-0004-3

Jiang, S. and Guo, Y. (2020) Epigenetic Clock: DNA Methylation in Aging. Stem Cells International doi: 10.1155/2020/1047896

Mammalian Methylation Consortium (2021) Universal DNA methylation age across mammalian tissues. bioRxiv doi: 10.1101/2021.01.18.426733

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FOOTAGE, IMAGES, AND MUSIC CREDITS
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Stock pictures from Shutterstock
Stock footage from Videoblocks

Picture of Steve Horvath: Brad Swonetz/Redux/Eyevine

Music: "Monkey races" by Eric Matyas
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#Epigenetics #Aging #EpigeneticClocks #Longevity #DNA #Methylation #DNAMethylation