HLA subtypes diseases, NK cells | Cellular components | Immunology | First Aid Lectures | Lec.6
Channel: Dr. Jamil Lectures
Date: 24/03/2022

In this lecture we will discuss about HLA subtypes associated with diseases, Natural killer cells their functions , antibody dependent cell-mediated cytotoxicity

https://youtu.be/r9yQe_u8keQ
https://youtu.be/2SoV1_tE0cU
https://youtu.be/aP06bUvyqCA

Instagram account    dr_jamil56


HLA subtypes associated with diseases 
HLA subtype B27 causes Psoriatic arthritis, Ankylosing spondylitis, IBD associated arthrtitis, Reactive arthritis
HLA subtype C causes Psoriasis 
SLE is caused by HLA subtype DR2, DR3
Hashimoto thyroiditis is caused by HLA subtype DR3 and DR5
DM type 1 is caused by  HLA subtype DR3 and DR4

Natural killer cells
It is lymphoctye origin of innate immunity. These cells use perforin and granzyme to induce apoptosis of virally infected cells and tumor cells, its activity is increased by  IL--2, IL-12, INF-alpha and IFN-beta. it is induced to kill when an absence of MHC I on cancer cell surface. it also kills via antibody dependent cell mediated cytotoxicity.

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