Episode 20: Mini Brains – Organoids as 3D Brain Models
Channel: Preprints in Motion
Date: 25/03/2022

This week we discuss organoids and assembloids as models of neurodegenerative diseases with Sònia Sabaté Soler (@scisonias), a PhD student from the University of Luxembourg (@uni_lu). Find out about how 2D stem cells cultures are differentiated into complex 3D midbrain organoids which contain multiple cell types. We also discuss how microglia can be incorporated into the organoids to generate assembloids, mimicking the human brain more robustly. As always we speak about pre-printing and academic culture. We touch on some of the limitations on academia partially with reference to women in STEM and the potential of permanent post docs. 

Read the full preprint: https://www.biorxiv.org/content/10.1101/2022.01.21.477192v1.full

This episode was produced by Emma Wilson and edited by John D Howard . 

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Produced by JEmJ Productions (find us on Twitter: Jonny @JACoates, Emma @ELWilson92, John @JohnDHoward8) and generously supported by ASAPbio (https://asapbio.org | @asapbio_).