Cancer biomarkers | Wikipedia audio article
Channel: wikipedia tts
Date: 06/06/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Cancer_biomarker


00:01:27 1 Definitions of cancer biomarkers
00:02:46 2 Role of biomarkers in cancer research and medicine
00:02:58 2.1 Uses of Biomarkers in cancer medicine
00:03:08 2.1.1 Risk assessment
00:04:07 2.1.2 Diagnosis
00:04:49 2.1.3 Prognosis and treatment predictions
00:06:13 2.1.4 Pharmacodynamics and pharmacokinetics
00:07:21 2.1.5 Monitoring treatment response
00:08:42 2.1.6 Recurrence
00:09:28 2.2 Uses of biomarkers in cancer research
00:09:39 2.2.1 Developing drug targets
00:10:42 2.2.2 Surrogate endpoints
00:12:45 3 Types of cancer biomarkers
00:12:56 3.1 Molecular cancer biomarkers
00:13:37 4 See also



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SUMMARY
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A cancer biomarker refers to a substance or process that is indicative of the presence of cancer in the body. A biomarker may be a molecule secreted by a tumor or a specific response of the body to the presence of cancer. Genetic, epigenetic, proteomic, glycomic, and imaging biomarkers can be used for cancer diagnosis, prognosis, and epidemiology. Ideally, such biomarkers can be assayed in non-invasively collected biofluids like blood or serum.While numerous challenges exist in translating biomarker research into the clinical space; a number of gene and protein based biomarkers have already been used at some point in patient care; including, AFP (Liver Cancer), BCR-ABL (Chronic Myeloid Leukemia), BRCA1 / BRCA2 (Breast/Ovarian Cancer), BRAF V600E (Melanoma/Colorectal Cancer), CA-125 (Ovarian Cancer), CA19.9 (Pancreatic Cancer), CEA (Colorectal Cancer), EGFR (Non-small-cell lung carcinoma), HER-2 (Breast Cancer), KIT (Gastrointestinal stromal tumor), PSA (Prostate Specific Antigen) (Prostate Cancer), S100 (Melanoma), and many others. Mutant Proteins themselves detected by Selected Reaction Monitoring (SRM) have been reported to be the most specific biomarkers for cancers because they can only come from an existing tumor.