Silvio C. E. Tosatto - Biocuration in DisProt
Channel: Biocuration Conference 2023
Date: 21/06/2023

*Title:* Biocuration in DisProt, the manually curated database for intrinsically disordered proteins

*Session:* April 25 - Applications 1 - 01

*Abstract:* DisProt (https://disprot.org/) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. DisProt relies on both professional and community curators who are provided with a variety of material to support their curation process. These include a curation manual, interactive exercises and training sessions that evolved from virtual training sessions to eLearning courses available in English and Spanish, along with in person training sessions. To provide comprehensive and standardized annotations, DisProt relies on the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) and on the adoption of the Minimum Information About Disorder (MIADE) standard. Higher quality and consistency of annotations is provided by a robust reviewing process - entries are reviewed and validated by expert curators that support other curators during the whole process. DisProt curators - both community and professional ones - continuously check the literature for novel experimental evidence for proteins belonging to eukaryota, bacteria, viruses and archaea, including also the model organisms represented in the DisProt home page. Finally, DisProt also focuses on thematic datasets, collections describing biological areas where IDPs play a crucial role, e.g. autophagy-related proteins and viral proteins. A new release of DisProt, pertaining technical and/or scientific content, is available every six months.