The changing tones of your DNA
Channel: Lifespan News
Date: 2021-02-04

There are tiny molecules sitting on top of your DNA that tone it up or down. The sequence of these molecules—the methylation pattern of your DNA—changes as you grow older, but is that a cause of aging or a consequence?

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SOURCES AND FURTHER READING
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Ciccarone F, Tagliatesta S, Caiafa P, Zampiere M. (2017) DNA methylation dynamics in aging: how far are we from understanding the mechanisms? Mechanisms of Ageing and Development 174, 3-17. doi: 10.1016/j.mad.2017.12.002

Cruickshanks HA, McBryan T, Nelson DM, VanderKraats ND, Shah PP, van Tuyn J, Singh Rai T, Brock C, Donahue G, Dunican DS, Drotar ME, MeehanRR, Edwards JR, Berger SL, Adams PD. (2013) Senescent cells harbour features of the cancer epigenome. Nature Cell Biology 15, 1495-1506. doi: 10.1038/ncb2879

Day K, Waite LL, Thalacker-Mercer A, West A, Bamman MM, Brook JD, Myers RM, Absher D. (2013) Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape. Genome Biology 14, R102. doi: 10.1186/gb-2013-14-9-r102

Megawa W, Hinkal G, Kim HS, Shen L,  Zhang L, Zhang J, Zhang N, Liang S, Donehower LA, Issa JP. (2010) Widespread and tissue specific age-related DNA methylation changes in mice. Genome Research 20, 332-340. doi: 10.1101/gr.096826.109

Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A. (2019) The role of DNA methylation in epigenetics of aging. Pharmacology & Therapeutics 195, 172-185. doi: 10.1016/j.pharmthera.2018.11.001

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FOOTAGE, IMAGES, AND MUSIC CREDITS
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#DNA #aging #methylation #Epigenetics #LifeExtension #genetics  #MolecularBiology