Point mutation | Wikipedia audio article
Channel: wikipedia tts
Date: 10/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Point_mutation


00:00:37 1 Causes
00:02:34 2 Categorization
00:02:44 2.1 Transition/transversion categorization
00:03:34 2.2 Functional categorization
00:07:16 2.3 Single base pair insertions and deletions
00:07:47 3 General consequences
00:13:32 4 Specific diseases caused by point mutations
00:13:45 4.1 Cancer
00:14:16 4.2 Neurofibromatosis
00:14:35 4.3 Sickle-cell anemia
00:17:11 4.4 Tay–Sachs disease
00:18:19 4.5 Color blindness
00:18:59 5 Repeat-induced point mutation
00:21:51 5.1 Mechanism
00:22:40 5.2 Consequences
00:23:23 5.3 Use in molecular biology
00:24:11 6 History



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SUMMARY
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A point mutation or substitution is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA. Point mutations have a variety of effects on the downstream protein product—consequences that are moderately predictable based upon the specifics of the mutation. These consequences can range from benign (e.g. synonymous mutations) to catastrophic (e.g. frameshift mutations), with regard to protein production, composition, and function.