Session V: Putting it all together: Cross cutting issues in PFAS risk assessment
Channel: National Academies - Earth and Life Studies
Date: 2020-12-15

Humans are exposed to multiple PFAS raising concerns about complex mixtures, PFAS interactions resulting in additivity and possible interaction between PFAS compounds. The toxicity of many PFAS chemicals is poorly characterized and additional exposures are likely to be revealed in the future. This session will examine the challenges and strategies in considering mixtures and developing class-based approaches for risk assessment.  Brief (3-4 min) presentations (live or prerecorded) by a lead federal agency will provide a concise overview of the current state of the science, what is likely to be known in the near future, and remaining data gaps. In this session, the participants will also discuss research needs to address emerging issues, including approaches and tools to rapidly respond to newly identified and next-generation PFAS, such as new strategies for chemical screening and new in vitro and computational toxicology approaches.