Does NMN Use Have Benefits? Human Trial Results
Channel: Lifespan News
Date: 30/07/2021

Study shows NMN Enhances Aerobic Capacity in Amateur Runners.

A recently published clinical trial of endurance runners found that the NAD+ precursor nicotinamide mononucleotide (NMN) increases several measures of aerobic capacity. 40 male and 8 female endurance runners in China were recruited for the study. For six weeks, participants took either a placebo or 150 mg, 300 mg, or 600 mg of powdered NMN twice per day, once in the morning and once at lunch or in the afternoon prior to a training run. In general, at peak effort, most measures were unchanged with NMN supplementation, such as VO2 max, maximum heart rate, and peak power. However, subjects showed a dose-dependent improvement of fitness at the more moderate effort of the first ventilatory threshold (VT1). For example, at VT1, subjects who took 600 mg NMN twice per day had higher VO2 and lower heart rates than the lower doses and placebo. Although there was no NMN-only group to compare to, it seems likely from previous studies that such a group would have been outperformed by the exercise groups. With this assumption, it can be concluded that the two interventions have a synergistic effect. The double-blind, placebo-controlled study design, as well as the dose-dependent relationship, provide a lot of confidence that NMN truly was responsible for the improvements seen in these subjects. While these results are encouraging, this was only a small study, and subjects were only followed for six weeks. Longer-term studies will need to build on these results, and hopefully, future investigations will get at the molecular pathways behind the physiological changes observed here.

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