Week 7: DC SIR Allergy Program and Fecal Microbiota Transplant FMT
Channel: PawsitivelyPrimal
Date: 2018-04-27

This is the first time we are using a purchased FMT for our Allergy Program. Follow along for Zuki's Progress.
For full references, please go to our Facebook Page.

FMT purchased at www.animalbiome.com
Week 1: DC SIR Allergy Program
https://www.youtube.com/watch?v=F7DJgcSvMBk&t=880s
Facebook with references:
https://www.facebook.com/PawsitivelyPrimal/videos/1617254471702684/
Fecal Microbiota Transplant the basics:
https://journals.lww.com/co-gastroenterology/Fulltext/2013/01000/Fecal_microbiota_transplantation___past,_present.14.aspx
Beyond GI disorders:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284325/  
Video Playlist on the Canine Microbiome:
https://www.youtube.com/playlist?list=PLPb3JZ1HEqPRBgXC1LsNWp0EMuS9GoRm3 
Facebook with full reference list: https://www.facebook.com/PawsitivelyPrimal/videos/1634890073272457/
History of FMT
https://www.research.va.gov/currents/winter2015/winter2015-11.cfm
https://www.news-medical.net/health/History-of-Fecal-Transplant.aspx 
Clostridium difficile
https://www.nature.com/articles/ctg201524 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128635/
https://academic.oup.com/gastro/article/5/3/200/3829209 
https://www.mayoclinic.org/medical-professionals/clinical-updates/digestive-diseases/fmt-demonstrates-consistently-high-success-rates-for-recurrent-cdi
https://www.medscape.com/viewarticle/890390
https://www.sciencedaily.com/releases/2017/06/170613163314.htm 
Poop as a Drug in the United States. (Not in Europe where they are using for multiple GI disorders)
https://blogs.scientificamerican.com/observations/hey-fda-poop-is-not-a-drug/
https://thepowerofpoop.com/us-food-drug-administration-classifies-fmt-an-investigational-new-drug/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5441021/
Reduce Crohn’s
https://www.nature.com/articles/s41598-017-04984-z 
CRP, Proinflammatory cytocynes, cathelicidins, diversity etc
http://www.jpp.krakow.pl/journal/archive/12_16/pdf/859_12_16_article.pdf
https://www.ncbi.nlm.nih.gov/pubmed/27542133
https://www.healio.com/gastroenterology/inflammatory-bowel-disease/news/online/%7Bd11864a3-d36a-4c75-b890-66dc53997280%7D/single-fmt-appears-safe-effective-for-increasing-microbial-diversity-in-uc
Disease associated with gut bacteria
https://www.frontiersin.org/articles/10.3389/fmicb.2016.01144/full
 Livestock transplant
http://www.oie.int/doc/ged/D8900.PDF
Tight Junction and Mucin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548832/
Butyrate 
http://todaysveterinarypractice.navc.com/intestinal-microbes-digestive-system-disease-dogs/ 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728689/
Normalize mucosal barrier function
Reverse immune dysfunction
Two main considerations
1. Antimicrobials antifungals – to give new beneficial bacteria opportunity to repopulate. However, this isn’t necessary because of competitive exclusion where the beneficial bacteria crowds out the harmful bacteria. Double edge sword – people who give month deworming other chemical toxins
2. Intestinal Permeability. Tight junction in the epithelial layer is open and mucin layer is depressed a combination allowing for foreign, pathogenic and beneficial bacteria to leave the intestine and enter the circulatory system. Our program assumes intestinal permeability and we take actionable steps to close tight junction and increase mucin through strategic actionable steps. Will have a dedicated video on these steps because of ‘if this then that’ - we know SCFA like butyrate and diverse microbiome contribute to healing and prevention of leaky gut. Increase SCFA with resistant starch – HOWEVER research shows that if the gut doesn’t have the right microbes (diversity lacking) then the bacteria turns RS into ammonia – not good. So our protocols are designed to address these potential pitfalls in order to prep for the issues. 

Animal Biome:
https://www.animalbiome.com/products/doggykit 
Dangerous Decks:
https://www.youtube.com/watch?v=LB0yxhr1nnE
Sensitivity Test and Diverse Microbiome:
https://www.facebook.com/PawsitivelyPrimal/posts/1576762102418588
Antibiotics and basics on Microbiome
https://www.facebook.com/pg/PawsitivelyPrimal/photos/?tab=album&album_id=1576735285754603
Dysbiosis Diagnostics
http://vetmed.tamu.edu/gilab/service/assays/canine-microbiota-dysbiosis-index
Bacterial profile associated with disease in humans
https://www.frontiersin.org/articles/10.3389/fmicb.2016.01144/full
FMT cause obesity –donor considerations
https://www.sciencealert.com/woman-becomes-obese-after-receiving-a-faecal-transplant-from-overweight-donor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438885/
Alopecia reversed from FMT
Dor full referencelist: See our Facebook Page.



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