How Science Made Nine People Grow Younger
Channel: Lifespan News
Date: 2021-07-10

Reversing aging rightfully sounds like something very complex, if at all possible. You'd probably have to fix and tweak a lot of things to keep people young forever, but is that right? A small study a few years back seemed to suggest that maybe, by "rebooting" your immune system, it might be possible to reverse several aspects of aging.

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SOURCES AND FURTHER READING
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The TRIIM Trial:

Fahy, G. M., Brooke, R. T., Watson, J. P., Good, Z., Vasanawala, S. S., Maecker, H., ... & Horvath, S. (2019). Reversal of epigenetic aging and immunosenescent trends in humans. Aging cell, 18(6), e13028. (https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13028)

Information on TRIIM-X here: https://clinicaltrials.gov/ct2/show/NCT04375657

A few talks and interviews with scientists from the TRIIM trial:

https://www.nature.com/articles/d41586-019-02638-w
https://www.youtube.com/watch?v=-ow_Tems3I0
https://www.lifespan.io/news/the-potential-of-thymus-regeneration/
https://www.youtube.com/watch?v=PFg-OMHvI2E
https://www.lifespan.io/news/dr-greg-fahy-appears-on-the-damage-report/
https://www.lifespan.io/news/rejuvenating-the-thymus/

Papers about the thymus and thymic involution:

Shanley, D. P., Aw, D., Manley, N. R., & Palmer, D. B. (2009). An evolutionary perspective on the mechanisms of immunosenescence. Trends in Immunology, 30(7), 374–381. doi:10.1016/j.it.2009.05.001 (https://pubmed.ncbi.nlm.nih.gov/19541538/)

George, A. J. T., & Ritter, M. A. (1996). Thymic involution with ageing: obsolescence or good housekeeping? Immunology Today, 17(6), 267–272. doi:10.1016/0167-5699(96)80543-3 (https://pubmed.ncbi.nlm.nih.gov/8962629/)

Dowling, M. R., & Hodgkin, P. D. (2009). Why does the thymus involute? A selection-based hypothesis. Trends in Immunology, 30(7), 295–300. doi:10.1016/j.it.2009.04.006 (https://pubmed.ncbi.nlm.nih.gov/19540805/)

STEINMANN, G. G., KLAUS, B., & MULLER-HERMELINK, H.-K. (1985). The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty. Scandinavian Journal of Immunology, 22(5), 563–575. doi:10.1111/j.1365-3083.1985.tb01916.x (https://pubmed.ncbi.nlm.nih.gov/4081647/)

Taub, D. D., & Longo, D. L. (2005). Insights into thymic aging and regeneration. Immunological Reviews, 205(1), 72–93. doi:10.1111/j.0105-2896.2005.00275.x 
(https://pubmed.ncbi.nlm.nih.gov/15882346/)

About immunosenescence, vaccines, and cancer:

Haq, K., & McElhaney, J. E. (2014). Immunosenescence: influenza vaccination and the elderly. Current Opinion in Immunology, 29, 38–42. doi:10.1016/j.coi.2014.03.008 (https://pubmed.ncbi.nlm.nih.gov/24769424/)

Palmer, S., Albergante, L., Blackburn, C. C., & Newman, T. J. (2018). Thymic involution and rising disease incidence with age. Proceedings of the National Academy of Sciences, 115(8), 1883-1888. (https://www.pnas.org/content/115/8/1883) 
See also an interview with one of the study authors here:
https://www.lifespan.io/news/thymic-involution-and-cancer-risk/

Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020). Immunosenescence: a key player in cancer development. Journal of Hematology & Oncology, 13(1), 1-18. (https://jhoonline.biomedcentral.com/articles/10.1186/s13045-020-00986-z)

If you want to learn more about the immune response and the aging of the immune system:
https://www.youtube.com/watch?v=zQGOcOUBi6s
https://www.youtube.com/watch?v=BSypUV6QUNw
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923430/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582124/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928693/

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FOOTAGE, IMAGES, AND MUSIC CREDITS
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Stock footage from VIdeoblocks and MotionElements

Music: "Monkey races" by Eric Matyas

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#thymus #immunesystem #rejuvenation #aging #epigenetics