Chemical synapse | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-12-28

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Chemical_synapse


00:02:08 1 Structure
00:05:09 2 Signaling in chemical synapses
00:05:20 2.1 Overview
00:07:38 2.2 Neurotransmitter release
00:09:34 2.3 Receptor binding
00:10:49 2.4 Termination
00:11:45 3 Synaptic strength
00:12:58 4 Receptor desensitization
00:13:40 5 Synaptic plasticity
00:14:31 5.1 Homosynaptic plasticity
00:15:42 5.2 Heterosynaptic plasticity
00:16:36 6 Integration of synaptic inputs
00:18:35 7 Volume transmission
00:20:11 8 Relationship to electrical synapses
00:21:41 9 Effects of drugs
00:22:58 10 History
00:23:43 11 See also



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SUMMARY
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Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands. Chemical synapses allow neurons to form circuits within the central nervous system. They are crucial to the biological computations that underlie perception and thought. They allow the nervous system to connect to and control other systems of the body.
At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron. The neurotransmitters are kept within small sacs called synaptic vesicles, and are released into the synaptic cleft by exocytosis. These molecules then bind to neurotransmitter receptors on the postsynaptic cell's side of the synaptic cleft. Finally, the neurotransmitters must be cleared from the synapse through one of several potential mechanisms including enzymatic degradation or re-uptake by specific transporters either on the presynaptic cell or possibly by neuroglia to terminate the action of the transmitter.
The adult human brain is estimated to contain from 1014 to 5 × 1014 (100–500 trillion) synapses. Every cubic millimeter of cerebral cortex contains roughly a billion (short scale, i.e. 109) of them. The number of synapses in the  human cerebral cortex has separately been estimated at 0.15 quadrillion (150 trillion)The word "synapse" comes from "synaptein", which Sir Charles Scott Sherrington and colleagues coined from the Greek "syn-" ("together") and "haptein" ("to clasp"). Chemical synapses are not the only type of biological synapse: electrical and immunological synapses also exist. Without a qualifier, however, "synapse" commonly means chemical synapse.