INCF at SfN 2012: DW Wheeler presents the Hippocampome Web Portal
Channel: INCF
Date: 06/11/2012

Demonstration during Society for Neuroscience (SfN), October 2012 in New Orleans. Presenter: DW Wheeler
Title: The Hippocampome Web Portal: open access to a knowledge base for the rodent hippocampus

Abstract:
The Hippocampome is a knowledge base of neuron types for the rodent hippocampus. A neuron type is primarily defined by the presence or absence of axons and dendrites in 26 neuroanatomical parcels delineated by the partition of the hippocampal complex into subregions (dentate gyrus, CA3, CA2, CA1, subiculum, and entorhinal cortex) and their respective histochemical layers (e.g. CA1 oriens, radiatum, etc.). With such an approach, sufficient morphological information is available in the literature to characterize over 100 neuronal types. Each neuronal type is assigned a human- and machine-readable unique identifier to unambiguously link it to the relevant references and to bridge the sometimes confusing nomenclature. This initial characterization is then augmented by including information on the electrophysiological properties and the molecular marker expression profile for each neuron type. The collation of evidence from multiple publications into a centralized repository enables data mining for new discoveries, such as the potential connectivity of the network of hippocampal classes. The Hippocampome web portal is designed to facilitate analytics with user-friendly browsing and searching and to allow for the universally accessible machine-readable download of information.

http://www.hippocampome.org/