Hack Your Genome Workshop -part 2: Longevity genetics
Channel: just-dna-seq
Date: 2022-06-17

The section "Longevity Genetics" of the "Hack Your Genome Workshop" – a free virtual event dedicated to providing guidance in personal genomic data analyzing, and longevity genetics.

Speakers:
* Anton Kulaga – bioinformatician, leader of the project
* Olga Borysova – biologist, geneticist, mitochondria expert, and founder of MitoSpace; responsible for the reports and bio stuff

Contents:
00:00 - Introduction (Anton Kulaga)
00:41 - Heritability of diseases and traits
03:24 - Genetics of longevity
04:24     – Numbers of centenarians
05:59     – Determinants of exceptional human longevity
07:59     – high level of HTT intermediate alleles in centenarians
09:35     – Databases on aging

12:26 - Example of longevity genes (Olga Borysova)
15:55     – UCP genes
17:46     – Introduction to mitochondria metabolism for not biologists
20:53     – Uncoupling mechanism in mitochondria - UCP protein
22:44     – Brown fat - fat for fat burning
24:03     – Association of uncoupling with longevity
25:20     – When your brain boils - releasing of neurotransmitter - USP2 protein
26:26     – Uncouplers as potential drugs for age-related diseases

Slides: https://docs.google.com/presentation/d/1UAnBGjVf446uoWK0yb-hGE9RlbcKUPkf1s1iAQf80v0/

Folder with workshop documents: https://drive.google.com/drive/folders/1xVD4-aVnDP5DBq-Mc2WmPe3Z_L6sZ0N1 that contains:
- slides
- instruction for starting working with OpenCravat and uploading your own genome
- filters (pathogenic.json and pharm.json) that were used during the workshop


— Links from the presentation —
"Epigenetics of discordant monozygotic twins: implications for disease" (2014)
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-014-0060-z

"Determinants of exceptional human longevity: new ideas and findings" (2013)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165392

Journals of Gerontology: BIOLOGICAL SCIENCES, 2021, Vol. 76, No. 5, p. 755
"Polygenic Risk Score of Longevity Predicts Longer Survival Across an Age Continuum"
https://academic.oup.com/biomedgerontology/article/76/5/750/5996044

Gene interventions databases on aging
GenAge – The Ageing Gene Database: https://genomics.senescence.info/genes
SynergyAge – Long- and short-lived genetic mutants: https://www.synergyage.info

LongevityMap: Human Longevity Genetic Variants
https://genomics.senescence.info/longevity

"Longevity significant variations"
https://dna-seq.github.io/dna-seq/workshop/antonkulaga.vcf.longevity_combined.html

"Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program" (2020)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7104298/

"Mitochondrial uncoupling proteins in the cns: in support of function and survival" (2005)
https://www.nature.com/articles/nrn1767

"Uncoupling-to-Survive Theory: The Genetic Variation of Human UCP Genes Is Associated with Longevity" (2011)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029650