Alpha Yohimbine (Rauwolscine) Stimulant / Nootropic Review
Channel: RealJoshTv
Date: 2022-08-07

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Yohimbe is an herbal supplement. It has a long history of use in West African traditional medicine to improve sexual performance.

More recently, yohimbe has been sold as a dietary supplement with a wide variety of common uses. These range from treating medical conditions like erectile dysfunction to aiding in weight loss. The supplement is derived from the bark of an evergreen tree found in western and central Africa called the Pausinystalia johimbe.

It is often sold in capsule or tablet form and marketed as yohimbe bark extract or yohimbine, the active ingredient in yohimbe bark. Many believe that yohimbine works by blocking receptors in the body called alpha-2 adrenergic receptors. (Source) These receptors play an important role in inhibiting erections. Therefore, yohimbine is thought to help alleviate erectile dysfunction by blocking the receptors responsible for preventing erections (Source).

Yohimbine may also promote the release of nitric oxide. This could lead to the dilation of blood vessels and an increase in blood flow to sexual organs (Source). Namely, rauwolscine antagonizes alpha-2 adrenergic receptors and stimulates serotonin receptors. How does this enhance fat burning?


Rauwolscine is a stereoisomer of yohimbine, which is why the compound is commonly referred to as alpha-yohimbine. Rauwolscine is naturally occurring in rauwolfia vomitoria and functions remarkably similar to “standard” yohimbine.

Well, fat cells (adipocytes) have alpha and beta receptors. When fat-burning catecholamines (adrenaline and noradrenaline) bind to beta receptors, fat cells become “unlocked” and release their stored fatty acids into the bloodstream where they can be taken up by cells and used for energy.

However, when these chemicals bind to alpha receptors, fat burning is blunted. As an alpha-receptor antagonist, rauwolscine (alpha-yohimbine) binds to the alpha receptors, “clogging” them and preventing adrenaline and noradrenaline from binding. This allows greater amounts of the fat-releasing chemicals to bind to beta receptors and rev up the fat burning process.