Guardians of the Genome: The Cell Cycle Checkpoints
Channel: MHSc Medical Genomics
Date: 2023-12-05

Welcome to our webinar on the Guardians of the Genome! We hope to help everyone including high school and undergraduate students to learn more about the functions of the cell cycle checkpoints and possible dysfunctions that can occur. This video was a collaborative effort between Kajeetha Sarvananthan, Solomiya Hnatovska and Pooja Kiran Ravi, who are students in the Medical Genomics Program at UofT.
This video is created and distributed under the CC BY-NC-ND license. Please feel free to share this work unchanged for non-commercial use!

0:53 - Outline
1:23 - Brief overview of the cell cycle
3:21 - G1/S checkpoint normal function
5:52 - G1/S checkpoint dysfunction and cancer
6:41 - G1/S checkpoint quiz
7:38 - G2/M checkpoint normal function
9:25 - G2/M checkpoint dysfunction and cancer
10:02 - G2/M checkpoint quiz
11:17 - Spindle checkpoint normal function
12:54 - Spindle checkpoint dysfunction and cancer
13:25 - Spindle checkpoint quiz
15:09 - Overview
17:05 - Extra resources
17:09 - References


For those who want to learn more!
More about colorectal cancer - doi: 10.1155/2014/145289
More about Li Fraumeni Syndrome - doi: 10.1007/978-94-017-9211-0_1
More about the Checkpoints - doi: 10.1046/j.1365-2184.2000.00191.x
More about CDKs (l - https://www.khanacademy.org/science/ap-biology/cell-communication-and-cell-cycle/regulation-of-cell-cycle/v/cell-cycle-control