Dopamine reuptake inhibitor | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-12-11

This is an audio version of the Wikipedia Article:
Dopamine reuptake inhibitor


00:01:16 1 Society and culture
00:01:26 1.1 History of use
00:01:53 2 Pharmacotherapeutic uses
00:04:43 3 List of DRIs
00:05:09 3.1 Selective dopamine reuptake inhibitors
00:07:13 3.2 DRIs with substantial activity at other sites
00:07:46 3.3 Other DRIs
00:08:04 4 See also



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SUMMARY
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A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic neuron is blocked from re-entering the presynaptic neuron. This results in increased extracellular concentrations of dopamine and increase in dopaminergic neurotransmission.DRIs are used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy for their psychostimulant effects, and in the treatment of obesity and binge eating disorder for their appetite suppressant effects. They are sometimes used as antidepressants in the treatment of mood disorders, but their use as antidepressants is limited given that strong DRIs have a high abuse potential and legal restrictions on their use. Lack of dopamine reuptake and the increase in extracellular levels of dopamine have been linked to increased susceptibility to addictive behavior given increase in dopaminergic neurotransmission. The dopaminergic pathways are considered to be strong reward centers. Many DRIs such as cocaine are drugs of abuse due to the rewarding effects evoked by elevated synaptic concentrations of dopamine in the brain.