The Destroyer (Impossible) - Columbus' Voyage 5 - American Conquest
Channel: RafaSheep
Date: 2020-12-30

This is a simple one: The enemy base starts empty, while you start with a substantial force. That means time to rush.

Send all your troops into the middle of the enemy base, directly towards the Fortress. Their buildings will mostly be ungarrisoned at the start, so a single unit is enough to capture them. The Dwellings are top priority, as they will periodically spawn Peasants to garrison the Fortress.

Order the Harquebusiers to shoot into the Fortress before sending them inside. Once it is captured, you've effectively won and the rest is mopping up.

To the north of your starting position is an Aztec base that will send small groups of Archers to set fire to the Mayan buildings. They will require Iron as an initial payment, so you may want to have an Iron Mine set up so that your Harquebusiers are able to shoot, if you haven't taken the Fortress already. The Mayans are able to send Peasants to repair their buildings, so the investment may not be worth it. 
Further to the north, is a Ruin which contains Gold. It won't affect your progress significantly.