ICE (chemotherapy) | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-06-06

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/ICE_(chemotherapy)


00:00:55 Dosing regimen



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SUMMARY
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ICE in the context of chemotherapy is an acronym for one of the chemotherapy regimens, used in salvage treatment of relapsed or refractory non-Hodgkin's lymphoma and Hodgkin lymphoma.
In case of CD20-positive B cell lymphoid malignancies the ICE regimen is often combined today with rituximab. This regimen is then called ICE-R or R-ICE or RICE.
[R]-ICE regimen consists of:

(R)ituximab - an anti-CD20 monoclonal antibody, which is able to kill both normal and malignant CD20-bearing B cells;
(I)fosfamide - an alkylating antineoplastic agent of the oxazafosforine group;
(C)arboplatin - a platinum-based antineoplastic drug, also an alkylating antineoplastic agent;
(E)toposide - a topoisomerase inhibitor.