MYO-INOSITOL AS A POTENTIAL LOCALLY SUPPRESSING ANTI-SEIZURE THERAPEUTIC AGENT
Channel: SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY
Date: 2022-03-13

Required for all manuscripts in which the epilepsy belongs to several neurological diseases whose treatment is currently symptomatic, and some patients are resistant to anticonvulsant drugs. Thus, it is essential to create and discover antiepileptic medications. Myo-inositol (MI) is considered to be a future cure agent for epilepsy. In this study, using an electrophysiological method, we revealed that MI has a time and concentration-dependent anticonvulsant effect. During the experiment, two bipolar electrodes were inserted into the dorsal hippocampal structure along with a cannula. MI and saline were injected, and the subsequent duration of electrical stimulation-induced after discharge were recorded from the same location in the hippocampus. 5 minutes after 1 M of MI infusion, the duration of the afterdischarge was significantly reduced compared with the duration of the pre-injection after discharge in the same animals and the duration of the pre-injection afterdischarges in animals administered saline or MI in the contralateral hippocampus. In addition, 0.055 M myo-inositol significantly decreased the afterdischarge duration at 5 minutes after injection as compared to 40 minutes post-injection. It should be noted that  after the injection of different MI concentrations (1.0 M and 0.055 M), the afterdischarge duration was restored to its initial value (pre-injection afterdischarge duration) 40 minutes after the MI injection. For the first time it was demonstrated that myo-inositol has time and concentration-dependent effects on the evoked seizure afterdischarges. Based on the results obtained from previous laboratory studies and current data, it was concluded that MI has a local suppressive effect on seizures and is therefore considered a promising therapeutic agent for treating patients with epilepsy.