Type 3 hypersensitivity | Immunology | First Aid Lectures | Lec24 #drjamillectures #drjameellectures
Channel: Dr. Jamil Lectures
Date: 2022-04-10

In this lecture we will discuss about type 3 hypersensitivity.Examples like serum sickness,Diphtheria serum,drug associated serum sickness,HBV passive immunization serum sickness,Arthus Reaction,pneumonitis,Tetnus immunization,SLE,poststreptococcal glomerulonephritis and polyartiritis.

https://youtu.be/2UJeTuPfNww
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https://youtu.be/aP06bUvyqCA

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Type 3 hypersensitivity
Immune complex—antigen-antibody (mostly 
IgG) complexes activate complement, which 
attracts neutrophils; neutrophils release 
lysosomal enzymes. 
Can be associated with vasculitis and systemic 
manifestations
Examples:
 SLE
 Polyarteritis nodosa
 Poststreptococcal glomerulonephritis
Serum sickness
the prototypic immune 
complex disease. Antibodies to foreign proteins 
are produced and 1–2 weeks later, antibody antigen complexes form and deposit in tissues 
complement activation  inflammation 
and tissue damage
Fever, urticaria, arthralgia, proteinuria, 
lymphadenopathy occur 1–2 weeks after 
antigen exposure. Serum sickness-like 
reactions are associated with some drugs (may 
act as haptens, eg, penicillin) and infections 
(eg, hepatitis B).
Arthus reaction
a local subacute immune 
complex-mediated hypersensitivity reaction. 
Intradermal injection of antigen into a 
presensitized (has circulating IgG) individual 
leads to immune complex formation in the 
skin (eg, enhanced local reaction to a booster 
vaccination). Characterized by edema, 
necrosis, and activation of complement.

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