Aging: Extracellular Vesicle Cargo in Aging
Channel: Aging (Aging-US)
Date: 2021-08-05

Aging published this trending editorial on July 20, 2021, entitled, “Mitochondria as extracellular vesicle cargo in aging” by researchers from the Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Baltimore, MD.

Aging is associated with chronic low-grade inflammation that likely contributes to many age-related diseases. In this trending 2021 editorial published by Aging, authors discuss the release of mitochondrial DNA (mtDNA) which can be initiated by cellular damage or stress.
 
“Due to the similarities between mtDNA and bacterial DNA, this release can in turn elicit a sterile inflammatory response through activation of the innate immune system.”

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.203358

DOI - https://doi.org/10.18632/aging.203358

Full text - https://www.aging-us.com/article/203358/text

Correspondence to: Michele K. Evans email: me42v@nih.gov

Keywords: exosomes, extracellular vesicles, mitochondria, mitochondrial DNA, biomarker, aging, microvesicles, circulating cell-free mitochondrial DNA

About Aging

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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