Hill equation (biochemistry) | Wikipedia audio article
Channel: wikipedia tts
Date: 18/02/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Hill_equation_(biochemistry)


00:00:48 1 Hill equation (mathematical model)
00:04:58 1.1 Hill plot
00:07:19 2 Derivation from mass action kinetics
00:14:09 3 Applications to mathematical modeling
00:14:19 3.1 Regulation of gene transcription
00:17:08 4 Limitations
00:18:10 5 Hill Coefficient
00:19:14 6 Response Coefficient
00:19:54 7 Link between Hill Coefficient and Response coefficient
00:21:35 8 See also



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SUMMARY
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In biochemistry and pharmacology, the binding of a ligand to a macromolecule is often enhanced if there are already other ligands present on the same macromolecule (this is known as cooperative binding). The Hill equation, which was originally formulated by Archibald Hill in 1910 to describe the sigmoidal O2 binding curve of haemoglobin, is used to describe the fraction of a macromolecule saturated by ligand as a function of the ligand concentration. The equation is useful for determining the degree of cooperativity of the ligand(s) binding to the enzyme or receptor. The Hill coefficient provides a way to quantify the degree of interaction between ligand binding sites.The Hill equation is formally equivalent to the Langmuir isotherm, and as a result, it is sometimes referred to as the Hill-Langmuir equation.