What is Causing Your Cells to Tear? New Findings Released
Channel: Lifespan News
Date: 31/01/2023

New research into senescent cells found they can adhere to neighboring cells, eventually ripping apart and leaving fragments of themselves inside their victims. Learning how they work could help us figure out the relationship between senescent cells and cancer. 

In this new preprint study, scientists marked 1 out of every 1000 cells with a fluorescent protein.  In group one, the fluorescent cells were senescent. In the second group, it was the opposite. In the third group, all cells were senescent, and, finally, the control group contained only healthy cells.
What they found was pretty amazing. After a few days tiny fluorescent dots started to appear. The cells were already tiny but these new dots were even tinier, and they turned out to be cellular fragments attached to the membranes of other cells. Time-lapses showed how the cells moved around and bumped into each other. Contacts between non-senescent cells were brief and ended without damaging either cell but, if at least one of the cells was senescent, they sometimes bonded together. Then as the cells eventually moved apart, the senescent cell was torn, leaving a part of itself attached to the other cell.

The fragments began appearing just 3 days after the induction of senescence, and by day 4 there were an average of 10-12 fragments per senescent cell.

The researchers also wanted to see what effects the fragments have on the cells. Adding these fragments to liver cancer cells increased their growth rate. In 3D culture, cancer cells with the fragments became more active, invading the gel and forming branches.

There have been other studies that have demonstrated some benefits of senescence, so even down to the cellular level there's good and evil in all of us and we're going to need more information before we know how we should respond.

SOURCES AND FURTHER READING
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Senescent cells deposit intracellular contents through adhesion-dependent fragmentation - https://www.biorxiv.org/content/10.1101/2023.01.11.523642v1.full

Senescent Cells Leave Fragments Attached to Other Cells - https://www.lifespan.io/news/senescent-cells-attach-their-fragments-to-other-cells/

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