Biophysical Chemistry 2018 - Lecture 12
Channel: Erik Lindahl
Date: 17/04/2018

Modern drug design. Agonists, partial agonists, inhibitors, and inverse agonists. ADME/Tox. Finding hits and optimizing leads. High-throughput screening and virtual high-throughput screening (=docking). QSAR, Pharmacophores. Pre-clinical testing and clinical Phase I/II/III tests. Failing early is failing cheap. The explosion of GPCR structures. Using docking and simulations to understand GPCR activation.