MIDL 2021, H12, Shi et. al., Full Paper
Channel: MIDL Society
Date: 08/08/2021

H12 - Unseen Disease Detection for Deep Learning Interpretation of Chest X-rays   

Siyu Shi, Ishaan Malhi, Kevin Tran, Andrew Y. Ng, Pranav Rajpurkar   

Conference page: https://2021.midl.io/papers/H12   

Abstract: We systematically evaluate the performance of deep learning models in the presence of diseases not labeled for or present during training. First, we evaluate whether deep learning models trained on a subset of diseases (seen diseases) can detect the presence of any one of a larger set of diseases. We find that models tend to falsely classify diseases outside of the subset (unseen diseases) as `no disease''. Second, we evaluate whether models trained on seen diseases can detect seen diseases when co-occurring with diseases outside the subset (unseen diseases). We find that models are still able to detect seen diseases even when co-occurring with unseen diseases. Third, we evaluate whether feature representations learned by models may be used to detect the presence of unseen diseases given a small labeled set of unseen diseases. We find that the penultimate layer provides useful features for unseen disease detection. Our results can inform the safe clinical deployment of deep learning models trained on a non-exhaustive set of disease classes.