The Pharmaceutic Political Compass
Channel: Liam Skoda
Date: 21/12/2023

This video introduces the Biopharmaceutics Classification System as a conceptual model for understanding drug properties based on water solubility and membrane permeability. 

Minor voiceover error: At 00:24:23 I state "for class 1 and 2 it's more variable" I should have said "for class 1 and 3 it's more variable". I hope this was reasonably clear from context as I had just stated that class 2 and 4 have poor solubility and are highly protein bound. 

Slides and animations were made in Microsoft PowerPoint 365, are my own work and free for reuse (suggest using 4K version). Content developed during preparation for College of Intensive Care Medicine (CICM) primary exam. 

References and Further Reading (Social Media): 
Deranged Physiology: https://derangedphysiology.com/main/home

Milrinone reference (via Deranged Physiology):
https://www.nejm.org/doi/full/10.1056/nejm199111213252103

Databases:
https://go.drugbank.com/
https://pubchem.ncbi.nlm.nih.gov/
https://www.chemspider.com/

00:00:00 Start
00:00:22 Absorption
00:01:25 Political Compass Analogy
00:03:28 Biopharmaceutics Classification System
00:04:41 Permeability, Log P and Caco-2
00:08:09 Water solubility and dose number
00:10:55 BCS implications for enteral absorption
00:12:29 Log P scale
00:12:50 BCS chart and fractional absorption categories
00:13:32 Opioids
00:15:43 NSAIDs
00:16:02 General anaesthetic agents
00:17:06 Benzodiazepines
00:17:25 Other psychotropic agents
00:17:45 Phosphodiesterase inhibitors
00:18:17 Calcium channel blockers
00:18:40 Beta blockers and other anti-arrhythmics
00:19:29 PPIs, metoclopramide and domperidone
00:20:03 Anticonvulsants
00:20:27 ARBs, GTN and catecholamines
00:21:02 Antibiotics
00:21:34 Neuromuscular blocking drugs and peptides
00:22:09 Aperients, antacids, diuretics and other class 3/4 agents
00:23:06 Summary of classes
00:24:10 Water solubility and protein binding
00:24:25 References and further reading
00:25:22 End