DNA graffiti: mutation patterns in cancer | The Royal Society
Channel: The Royal Society
Date: 2023-01-12

human cancers are highly individual. Etched into the DNA of cancers are graffiti-like mutation patterns, which could reveal underlying biological abnormalities, unique to each person’s cancer, with potential for application in precision medicine. 

In this lecture, Professor Serena Nik-Zainal will describe how her team have explored the extraordinary DNA graffiti that has been seen in human cancers, using a combination of big data computational approaches and systematic experimental methods. She will provide an account of how they have designed algorithms that could be used to interpret cancer genomes for clinical purposes and how they have taken steps towards clinical validation studies for her algorithms. Professor Nik-Zainal will touch on her team’s recent endeavour, reporting the largest cohort of WGS cancers worldwide of nearly 20,000 patients recruited via the NHS. She will end by bringing the audience through a selection of real cancer WGS patient stories

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