Neutrophils (function, kinetics and shifts)
Channel: clinical pathology - Dr. Khalid 
Date: 24/09/2023

• Neutrophils are a type of white blood cell and are an essential part of the immune system. 
• They play a crucial role in defending the body against bacterial and fungal infections by Phagocytosis and Microbial killing. 
• Also, Neutrophils play a role in initiating and promoting the inflammatory response. 
• The kinetics of neutrophils refers to their movement and behavior within the body, particularly in response to an infection or inflammation. This includes the processes of recruitment, migration, activation, and clearance. 
• Recruitment: When an infection or inflammation occurs, neutrophils are rapidly recruited from the bloodstream to the site of infection.
• Margination: Margination refers to the neutrophils' ability to adhere to the walls of blood vessels, particularly in the capillaries near the infected or inflamed area. 
• Diapedesis: Once the neutrophils have margined, they undergo diapedesis, which is the process of squeezing between endothelial cells and migrating out of the blood vessels and into the surrounding tissue. 
• Chemotaxis: Neutrophils possess the ability to detect and follow chemical gradients, allowing them to navigate towards the site of infection or inflammation. 
• Neutrophils have a relatively short lifespan, typically ranging from a few hours to a few days. After fulfilling their role in fighting infection, neutrophils undergo programmed cell death, known as apoptosis.
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