AMIKACIN INJECTION, BASIC USE, SAFE DOSE, INDICATIONS, CONTRAINDICATIONS, SIDE EFFECTS, ANTIBIOTICS,
Channel: PHARMAROCKS THE WAY OF SUCCESS
Date: 17/01/2021

AMIKACIN INJECTION
Amikacin is an antibiotic medication used for a number of bacterial infections. 
Amikacin is aminoglycoside antibiotics class of medication.
It is used by injection into a vein using an IV or into a muscle, IM.
Amikacin was patented in 1971, and came into commercial use in 1976.

AMIKACIN INJECTION BASIC USE
Thus amikacin use to treat a wide variety of bacterial infections
urinary tract, bones and joints, lungs, pneumonia, brain, blood.
It is also used in hospitalized patients to prevent spread of infections.

AMIKACIN INJECTION BASIC USE
Different bacterial infections
Joint infections, 
Intra-abdominal infections, 
Meningitis, 
Pneumonia, 
Sepsis (घाव का सड़ना)
Urinary tract infections. 
Multidrug-resistant tuberculosis

ABOUT AMIKACIN DRUG
It is a semisynthetic derivative of kanamycin to which it resembles in pharmacokinetics, dose and toxicity.
The aminoglycosides are a group of antibiotics of complex chemical structure, resembling each other in antimicrobial activity,
Bactericidal antibiotics because they kill bacteria directly

AMIKACIN MECHANISM OF ACTION
Amikacin is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. 
Inhibit protein synthesis at 30S subunit
The term can also refer more generally to any organic molecule that contains amino sugar substructures.

AMIKACIN INDICATION & USES
1. Gram negative infection.
2. Septicaemia abdominal sepsis
3. Post operative UTI.
4. Tuberculosis infection.
5. Infection of bones, 
6. Infection of skin, 
7. Infection of soft tissue & Joints.
8. Pelvic inflammatory disease.

AMIKACIN DOSE
Injectable solution
50mg/ml
250mg/ml
General dosing
15 mg/kg/day divided IV/IM q8-12hr
Urinary tract infection
250 mg IV/IM q12hr
First dose: 15 mg/kg IV based on lean body weight 

AMIKACIN ADVERSE EFFECT
1. Ototoxicity, Hypersensitivity reactions.
2. Nephrotoxicity, Hemolytic Anemia, Leukopenia.
3. Neuromuscular blockage, Thrombocytopenia.
4. Nausea/ vomiting, elevated liver enzyme.
5. Diarrhoea, Phlebitis. inflammation of a vein

AMIKACIN ADVERSE EFFECT
High doses may develop balance disorder (loss of balance)
Kidney damage
Hearing loss.
Increased blood urea
Injection site reactions (pain, swelling, redness)
Paralysis, resulting in the inability to breathe
If used during pregnancy it may cause permanent deafness in the baby, means cause hearing loss

AMIKACIN CONTRAINDICATION & PRECAUTIONS
Drug is contraindicated for pregnant and breast feeding women, it is cautiously used in patient with renal failure
Pregnancy: foetal ototoxicity
With other ototoxic drugs: furosemide, minocycline
With nephrotoxic drugs: vancomycin ,cisplatin
Elderly patients, Those with kidney disease
Cautious use of muscle relaxants
Do not mix with any other drug in same syringe

AMIKACIN DRUG INTERACTIONS
It may cause ototoxicity use with loop diuretic or another aminoglycosides. 
So don’t use them in combination with amikacin
Inactivation occurs if penicillin antibiotics mixed with aminoglycosides

AMIKACIN INJECTION SAFE USE
For safe use of Amikacin injection must follow condition
1. PROPER DIAGNOSIS
2. PATIENT COUNCLLING
3. MEDICAL HISTORY
4. INJECTION BY EXPERT ONLY
5. MUST READ WARNINGS/ CONTAINDICATIONS BEFORE USE 


#amikacin
#mikacin
#antibiotics

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