Biological functions of nitric oxide | Wikipedia audio article
Channel: wikipedia tts
Date: 18/02/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Biological_functions_of_nitric_oxide


00:01:11 1 Sources of NO
00:01:21 1.1 NO biosynthesis
00:04:14 1.2 Exogenous NO (NO-delivery drugs)
00:05:50 1.3 Other, including dietary
00:08:52 2 Immune response
00:12:02 3 Molecular effects of NO on biological systems
00:12:29 3.1 S-nitrosation of thiols
00:13:04 3.2 Nitrosylation of metal centers, especially iron
00:14:21 3.3 Guanylate cyclase
00:15:27 4 Smooth muscles
00:15:37 4.1 Vasodilation
00:17:33 4.2 Cardiac effects
00:18:16 5 Effects on plants
00:20:14 6 Effects in insects
00:20:47 7 Effects in bacteria
00:21:51 8 Medical use
00:22:01 8.1 Neonatal use
00:22:53 8.2 Pathology
00:23:39 8.3 Pediatric and adult use
00:25:14 8.4 Dosage and strength
00:25:52 8.5 Contraindications
00:26:45 8.6 Fatty liver disease
00:27:09 8.7 Pulmonary embolism
00:27:31 8.8 Pharmacology
00:29:38 8.9 Associated problems
00:30:23 8.10 Mechanism of action
00:31:40 8.10.1 Pharmacokinetics
00:32:30 8.11 Lung infection



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SUMMARY
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Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of NO. In mammals including humans, nitric oxide is a signaling molecule involved in many physiological and pathological processes. It is a powerful vasodilator with a half-life of a few seconds in the blood. Standard pharmaceuticals such as nitroglycerine and amyl nitrite are precursors to nitric oxide. Low levels of nitric oxide production are typically due to ischemic damage in the liver.
As a consequence of its importance in neuroscience, physiology, and immunology, nitric oxide was proclaimed "Molecule of the Year" in 1992. Research into its function led to the 1998 Nobel Prize for elucidating the role of nitric oxide as a cardiovascular signalling molecule.