Prothrombin complex | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-01-23

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Prothrombin_complex_concentrate


00:01:21 1 Medical uses
00:02:22 2 Contraindications
00:03:01 3 Chemistry
00:03:26 4 History



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SUMMARY
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Prothrombin complex concentrate (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, IX, and X. Some versions also contain factor VII. It is used to treat and prevent bleeding in hemophilia B if pure factor IX is not available. It may also be used in those with not enough of these factors due to other reasons such as warfarin therapy. It is given by slow injection into a vein.Common side effects include allergic reactions, headache, vomiting, and sleepiness. Other serious side effects include blood clots which may result in a heart attack, stroke, pulmonary embolism, or deep vein thrombosis. Antibodies may form after long term use such that future doses are less effective.Prothrombin complex concentrate came into medical use in the 1960s. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. It is made from human plasma. A version that is made by recombinant methods which only contains factor IX is also available. In the United States a dose of PCC costs about 900 USD. A number of different formulations are available globally.