Rapamycin Treatment Early in Life Reprograms Aging: Hyperfunction Theory and Clinical Practice
Channel: Aging (Aging-US)
Date: 02/11/2022

Aging (Aging-US) published this trending research perspective in Volume 14, Issue 20, entitled, “Rapamycin treatment early in life reprograms aging: hyperfunction theory and clinical practice” by Dr. Blagosklonny from Roswell Park Comprehensive Cancer Center, Buffalo, NY.
#aging  #lifespan #healthspan #longevity #openscience #openaccess #senescence 

DOI - https://doi.org/10.18632/aging.204354

Corresponding author - Mikhail V. Blagosklonny - Blagosklonny@oncotarget.com
 
ABSTRACT

Making provocative headlines, three outstanding publications demonstrated that early-life treatment with rapamycin, including treatments during developmental growth, extends lifespan in animals, confirming predictions of hyperfunction theory, which views aging as a quasi-program (an unintended continuation of developmental growth) driven in part by mTOR. Despite their high theoretical importance, clinical applications of two of these studies in mice, Drosophila and Daphnia cannot be implemented in humans because that would require growth retardation started at birth. A third study demonstrated that a transient (around 20% of total lifespan in Drosophila) treatment with rapamycin early in Drosophila adult life is as effective as lifelong treatment, whereas a late-life treatment is not effective. However, previous studies in mice demonstrated that a transient late-life treatment is highly effective. Based on hyperfunction theory, this article attempts to reconcile conflicting results and suggests the optimal treatment strategy to extend human lifespan.

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Keywords - aging, senescence, gerostatics, geroscience, sirolimus, healthspan

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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