How the tangles in your DNA make you age
Channel: Lifespan News
Date: 2021-01-07

Two or three meters of DNA are packed into each of your cells, but that careful arrangement gets muddled over time, which is one reason we grow old.

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SOURCES AND FURTHER READING
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Larson K, Yan SJ, Tsurumi A, Liu J, Zhou J, Gaur K, Guo D, Eickbush TH, Li WX. (2012) Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet. 8:e1002473.

Oberdoerffer P, Sinclair DA. (2007) The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol. 8:692–702.

Pegoraro G, Kubben N, Wickert U, Gohler H, Hoffmann K, Misteli T. (2009) Ageing-related chromatin defects through loss of the NURD complex. Nat Cell Biol. 11:1261–1267.

Pollina EA, Brunet A. (2011) Epigenetic regulation of aging stem cells. Oncogene 30:3105–3126.

Sun, L, Yu, R, and Dang, W. (2018) Chromatin Architectural Changes during Cellular Senescence and Aging. Genes 9, 211. doi:10.3390/genes9040211

Tsurumi A, Li WX. (2012) Global heterochromatin loss: a unifying theory of aging? Epigenetics 7:680–688.
 
Zhang, W, et al. (2015) A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science 348 (6239), 1160-1163.

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#DNA #Aging #epigenetics #chromatin #genetics #heterochromatin #LifeExtension #MolecularBiology