Anaphylaxis
Channel: JAM paeds
Date: 2020-12-12

Anaphylaxis occurs when the body is exposed to a substance that produces a severe allergic reaction, usually within minutes of the exposure. Although there is more than one mechanism by which anaphylaxis occurs, type I hypersensitivity is the most common (Hendry, 2012). Type I hypersensitivity occurs when an individual is exposed to a specific allergen and develops IgE antibodies.
These antibodies attach to mast cells in specific body locations, creating sensitized mast cells. Histamine and other chemical  mediators are released on reexposure to the same allergen, causing widespread responses in the skin, respiratory tract, and cardiovascular and gastrointestinal systems. Common causes of anaphylaxis include insect stings, latex, medications (e.g., penicillin,m sulfa), and some foods (e.g., shellfish, nuts, strawberries).