What Is SECRETIN? SECRETIN Definition & Meaning
Channel: Audiopedia
Date: 2018-11-06

What is SECRETIN, What does SECRETIN mean, SECRETIN meaning, SECRETIN definition, SECRETIN explanation

Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands.[3] In humans, the secretin peptide is encoded by the SCT gene.[4]

Secretin helps regulate the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate from the ductal cells of the pancreas.[5][6] It also stimulates bile production by the liver; the bile emulsifies dietary fats in the duodenum so that pancreatic lipase can act upon them. Meanwhile, in concert with secretin's actions, the other main hormone simultaneously issued by the duodenum, cholecystokinin, is stimulating the gallbladder to contract, delivering its stored bile for the same reason.

Prosecretin is a precursor to secretin, which is present in digestion. Secretin is stored in this unusable form, and is activated by gastric acid in the lower intestine to neutralize the pH and ensure no damage is done to the small intestine by the aforementioned acid.[7]

In 2007, secretin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.[8][9]
Source: Wikipedia.org