Can these sugars serve as a possible drug target for pancreatitis?
Channel: Cold Spring Harbor Laboratory
Date: 2019-06-20

CA19-9 is a complex sugar structure that coats proteins. Elevated levels of CA19-9 were found to cause inflammation in the pancreas in mice and promote rapid progression to pancreatic cancer. By neutralizing the functions of CA19-9 with antibodies, researchers were able to reduce and even prevent pancreatic damage in animal models.

Former CSHL Tuveson lab member Dani Engle (now Assistant Professor, Salk Institute) explains.

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