Chromophobe: A Framework For Comparative And Contrastive Evaluation Of Chromatin State Models
Channel: R Consortium
Date: 2022-08-29

Lauren Marie Harmon, with Van Andel Institute, presented a short talk at the Bioconductor Conference 2022. Harmon gave her presentation on chromophobe: A Framework For Comparative And Contrastive Evaluation Of Chromatin State Models. 

Harmon began the presentation by sharing background information including the formation of histones and modifications done. She then further explained the development of deciphering histone code into chromatin states and other modifications done to the chromatin landscape.  Afterward, Harmon introduced the work on the package chromophobe, `chromophobe` package automates many such simplifications. `chromophobe` leverages Bioconductor infrastructure for parallel processing, fast selective importation, and visualization of condition-dependent divergence in chromatin states, along with associated genomic and epigenomic signals. Harmon further explained its use to leverage existing BioC power tools and new diagnostics plots and tools, she also shared information received from a recent case study and the team’s use of the data. To wrap up, Harmon gave an overview of the current active developments of chromophobe. 

Read more information here: https://bioc2022.bioconductor.org/abstracts/paper60/  

Main Sections

0:00 Introduction
1:11 Deciphering the histone code into chromatin states
2:06 Learning hidden states from observed data
3:09 Recent additions to the chromatin landscape
4:17 chromophobe leverage existing BioC power tools
5:21 chromophobe adds new diagnostics plots and tools
7:50 chromophobe is under active development
8:35 Closing and thank you!


More Resources 

Bioconductor Conference Site: https://bioc2022.bioconductor.org/ 
BioC2022 Github: https://github.com/Bioconductor/BioC2022 

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