The Importance of Reproducible Research in High-Throughput Biology
Channel: VideoLecturesChannel
Date: 2012-12-12

VideoLectures.Net
View the talk in context: http://videolectures.net/cancerbioinformatics2010_baggerly_irrh/
View the complete Cancer Bioinformatics Workshop, Cambridge 2010: http://videolectures.net/cancerbioinformatics2010_cambridge/
Speaker: Keith A. Baggerly, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston 

License: Creative Commons CC BY-NC-ND 3.0
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0:00  The Importance of Reproducibility in High-Throughput Biology: Case Studies in Forensic Bioinformatics
1:19  Why is RR So Important in H-TB?
2:43  Using the NCI60 to Predict Sensitivity
5:19  Fit Training Data
5:58  Fit Testing Data
6:46  5-FU Heatmaps - 1
7:21  5-FU Heatmaps - 2
7:30  5-FU Heatmaps - 3
7:46  Their List and Ours
8:28  Offset P-Values: Other Drugs
9:02  Using Their Software
10:00  Heatmaps Match Exactly for Most Drugs! - 1
10:45  Heatmaps Match Exactly for Most Drugs! - 2
11:34  Predicting Docetaxel (Chang 03)
12:36  Predicting Adriamycin (Holleman 04)
13:51  There Were Other Genes...
15:12  RR Theme: Don't Take My Word For It!
15:45  Potti/Nevins Reply (Nat Med 13:1277-8)
16:51  Adriamycin 0.9999 + Correlations (Reply) - 1
17:54  Adriamycin 0.9999 + Correlations (Reply) - 2
18:22  The First 20 Files Now Named
19:14  Validation 1: Hsu et al
20:29  The 4 We Can't Match (Reply)
21:00  Some Timeline Here... - 1
21:12  Some Timeline Here... - 2
21:44  Some Timeline Here... - 3
22:00  Jan 29, 2010
22:21  Why We're Unhappy... - 1
22:44  Why We're Unhappy... - 2
23:25  We Tried Matching The Samples
24:36  FOI(L)A! - 1
24:54  FOI(L)A! - 2
25:32  May 14, 2010
25:53  July 16, 2010
26:21  July 19, 2010
26:48  Subsequent Events, and a Caveat - 1
27:13  Subsequent Events, and a Caveat - 2
27:30  Some Observations
28:09  What Should the Norm Be?
28:38  Some Lessons
29:42  Questions