Repeatable Crystallization Processes Developed by Chemists and Engineers – en
Channel: METTLER TOLEDO AutoChem
Date: 09/01/2012

Chemists and Chemical Engineers developed repeatable crystallization processes. Researchers track rate and degree of change to particles as they naturally exist in the crystallization process. Engineers from University College Dublin (UCD) optimized mixing and solvent addition which eliminated excessive nucleation. This minimized variability and downstream filtration. A more consistent yield was produced from the repeatable crystallization process. Researchers from Excella Germany optimized crystallization cooling rates. https://www.mt.com/us/en/home/applications/L1_AutoChem_Applications/L2_Crystallization.html?GLO_YT_Autochem_OTH_Youtube_Autochem

Important product attributes, such as crystal shape, size, and purity, are directly influenced by the choice of operating conditions during a crystallization. It is possible to repeatedly produce crystals of the correct shape, size, and purity while minimizing possible issues such as long filtration times or inadequate drying by understanding the crystallization process and selecting the correct process parameters.

Acting as purification and separation steps, having implications on the purity, yield, and particle size distribution, crystallization and precipitation are critical processing steps in chemical development. Many chemists have such short deadlines that they must base everyday decisions on past experience rather than understanding the crystals in situ, despite the significant advances crystallization has had over the past decade. A process can be developed as easily as crashing solids out of solution and transferring a non-robust process with inconsistencies in the purity, yield, and particle size distribution due to the complexity of crystallization.