Messenger RNA | Wikipedia audio article
Channel: wikipedia tts
Date: 04/10/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Messenger_RNA


00:01:25 1 Synthesis, processing and function
00:02:05 1.1 Transcription
00:02:51 1.2 Eukaryotic pre-mRNA processing
00:03:25 1.2.1 Splicing
00:03:48 1.2.2 5' cap addition
00:04:58 1.2.3 Editing
00:05:26 1.2.4 Polyadenylation
00:07:11 1.3 Transport
00:09:10 1.4 Translation
00:10:13 2 Structure
00:10:22 2.1 Coding regions
00:11:10 2.2 Untranslated regions
00:13:41 2.3 Poly(A) tail
00:14:06 2.4 Monocistronic versus polycistronic mRNA
00:15:04 2.5 mRNA circularization
00:16:34 3 Degradation
00:17:27 3.1 Prokaryotic mRNA degradation
00:18:26 3.2 Eukaryotic mRNA turnover
00:19:53 3.3 AU-rich element decay
00:20:46 3.4 Nonsense mediated decay
00:21:30 3.5 Small interfering RNA (siRNA)
00:22:15 3.6 MicroRNA (miRNA)
00:22:46 3.7 Other decay mechanisms
00:23:05 4 mRNA-based therapeutics
00:24:13 5 See also



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SUMMARY
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Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression. The RNA polymerase enzyme transcribes genes into primary transcript mRNA (known as pre-mRNA) leading to processed, mature mRNA. This mature mRNA is then translated into a polymer of amino acids: a protein, as summarized in the central dogma of molecular biology.
As in DNA, mRNA genetic information is in the sequence of nucleotides, which are arranged into codons consisting of three base pairs each. Each codon encodes for a specific amino acid, except the stop codons, which terminate protein synthesis. This process of translation of codons into amino acids requires two other types of RNA: Transfer RNA (tRNA), that mediates recognition of the codon and provides the corresponding amino acid, and ribosomal RNA (rRNA), that is the central component of the ribosome's protein-manufacturing machinery.
The existence of mRNA was first suggested by Jacques Monod and François Jacob, and subsequently discovered by Jacob, Sydney Brenner and Matthew Meselson at the California Institute of Technology in 1961.
It should not be confused with mitochondrial DNA.