Copy Number Variation as Tool for Implementing Pregnancy as Aging Model | Aging-US
Channel: Aging (Aging-US)
Date: 2023-09-06

Aging-US #published this #trending research #paper on August 28, 2023, in Volume 15, Issue 16, entitled, “Copy number variation as a tool for implementing pregnancy as an aging model" by researchers from the Department of Human Biology, University of Haifa, Haifa 3498838, Israel; Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel. @UniversityofHaifa @barilanuniversity 
#aging #pregnancy #geneexpression #research #researchpaper #openaccess  #openscience  #peerreview  #journal  #publication  #publishing  #meded 

DOI - https://doi.org/10.18632/aging.204936

Corresponding author - Gil Atzmon - gatzmon@univ.haifa.ac.il

Abstract

Copy number variations (CNV) are a major contributor to genome variability and have been linked to aging and other degradable phenotypes such as pregnancy physiology. To demonstrate how pregnancy can be used as a model of aging, we used CNVs from pregnant mice. Candidate CNVs were selected by applying case-control analysis in human centenarians compared with control groups. These CNVs were aligned with the mouse genome and their copy variation was assessed using qRT-PCR in liver and blood tissue samples from pregnant mice throughout pregnancy (baseline; first, second, and third trimester; post-partum). Eight of the ten selected CNVs demonstrated a significant decline/increase trend throughout the pregnancy followed by opposite direction soon after delivery in the liver and blood of the mouse tissues. Furthermore, significant differential expression was detected among the candidate CNVs’ close vicinity genes (APA2A, LSS, RBDHF1, PLAAT1, and SCL17A2), but not in the WSCD2 gene. Establishing a genetic link between longevity and pregnancy is a significant step toward implementing the pregnancy process as a model for aging. These results in pregnant mice highlight the mechanism and similarities between pregnancy and aging. Investigating the mechanisms that cause such rejuvenation after labor could change our aging treatment paradigm.

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Keywords - aging, pregnancy, copy number variation, gene expression

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Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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