Recombinant cytokines and therapeutic antibodies | Immunology | First Aid Lectures | Lec32 #drjamil
Channel: Dr. Jamil Lectures
Date: 25/04/2022

In this lecture we will discuss about recombinant cytokines drugs and therapeutic antibodies including cancer therapy, autoimmune disease therapy and other applications in immunopharmacology


https://youtu.be/BqQ5BasWJa0
https://youtu.be/CNXO-W0xw-A
https://youtu.be/aP06bUvyqCA


Instagram account    dr_jamil56


Recombinant cytokines and clinical uses
Erythropoietin Epoetin alfa (EPO analog) Anemias (especially in renal failure)
Colony stimulating 
factors
Filgrastim (G-CSF), Sargramostim (GM-CSF) Leukopenia; recovery of granulocyte and 
monocyte counts
Thrombopoietin Romiplostim (TPO analog), eltrombopag (TPO 
receptor agonist)
Autoimmune thrombocytopenia
Platelet stimulator
Interleukin-2 Aldesleukin Renal cell carcinoma, metastatic melanoma
Interferons IFN-α Chronic hepatitis C (not preferred) and B, renal 
cell carcinoma
IFN-β Multiple sclerosis
IFN-γ Chronic granulomatous disease
Therapeutic antibodies
Alemtuzumab CD52 CLL, multiple sclerosis “Alymtuzumab”—chronic 
lymphocytic leukemia
Bevacizumab VEGF Colorectal cancer, renal cell 
carcinoma, non-small cell 
lung cancer
Also used for neovascular agerelated macular degeneration, 
proliferative diabetic 
retinopathy, and macular 
edema
Rituximab CD20 B-cell non-Hodgkin 
lymphoma, CLL, rheumatoid 
arthritis, ITP, multiple 
sclerosis
Risk of PML in patients with 
JC virus
CD20—“ri2ximab”
Trastuzumab HER2 Breast cancer, gastric cancer HER2—“tras2zumab
Autoimmune disease therapy
Adalimumab, 
infliximab
Soluble TNF-α IBD, rheumatoid arthritis, 
ankylosing spondylitis, 
psoriasis
Etanercept is a decoy 
TNF-α receptor and not a 
monoclonal antibody
Eculizumab Complement protein C5 Paroxysmal nocturnal 
hemoglobinuria
Ixekizumab, 
secukinumab
IL-17A Psoriasis, psoriatic arthritis
Natalizumab α4-integrin Multiple sclerosis, Crohn 
disease
α4-integrin: WBC adhesion
Risk of PML in patients with 
JC virus
Ustekinumab IL-12/IL-23 Psoriasis, psoriatic arthritis
Abciximab Platelet glycoproteins IIb/IIIa Antiplatelet agent for 
prevention of ischemic 
complications in patients 
undergoing percutaneous 
coronary intervention
ABC is as easy as 123
Denosumab RANKL Osteoporosis; inhibits osteoclast
 maturation (mimics
osteoprotegerin)
Denosumab helps make dense 
bones
Omalizumab IgE Refractory allergic asthma; 
prevents IgE binding to FcεRI
Palivizumab RSV F protein RSV prophylaxis for high-risk 
infants



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