Alfaxalone | Wikipedia audio article
Channel: wikipedia tts
Date: 27/10/2018

This is an audio version of the Wikipedia Article:
Alfaxalone

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SUMMARY
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Alfaxalone, also known as alphaxalone or alphaxolone and sold under the brand name Alfaxan, is a neuroactive steroid and general anesthetic which is used in veterinary practice as an induction agent for anesthesia and as an injectable anesthetic. Though it is more expensive than other induction agents, it often preferred due to the lack of depressive effects on the cardiovascular system. The most common side effect is respiratory depression; when premedications aren't given, patients also become agitated and hypersensitive when waking up.
Alfaxalone works as a positive allosteric modulator on GABAA receptors and, at high concentrations, as a direct agonist of the GABAA receptor. It is cleared quickly by the liver, giving it a relatively short terminal half-life and preventing it from accumulating in the body, lowering the chance of overdose.