De novo pyrimidine and purine synthesis | Molecular biology | Biochemistry | First Aid lectures|Lec5
Channel: Dr. Jamil Lectures
Date: 12/05/2022

In this lecture we will discuss about Denovo pyrimidine and purine synthesis,purine synthesis and bridge to pharmacology,pyrimidine synthesis and bridge to pharmacology.


https://youtu.be/DwklPdL2Ga8
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De novo pyrimidine 
and purine synthesis
Various immunosuppressive, antineoplastic, and antibiotic drugs function by interfering with nucleotide synthesis:
Pyrimidine synthesis:
 Leflunomide: inhibits dihydroorotate 
dehydrogenase
 5-fluorouracil (5-FU) and its prodrug 
capecitabine: form 5-F-dUMP, which inhibits 
thymidylate synthase ( dTMP)
Purine synthesis:
 6-mercaptopurine (6-MP) and its prodrug 
azathioprine: inhibit de novo purine synthesis
 Mycophenolate and ribavirin: inhibit inosine 
monophosphate dehydrogenase
Purine and pyrimidine synthesis:
 Hydroxyurea: inhibits ribonucleotide 
reductase
 Methotrexate (MTX), trimethoprim (TMP), 
and pyrimethamine: inhibit dihydrofolate 
reductase ( deoxythymidine monophosphate 
[dTMP]) in humans, bacteria, and protozoa, 
respectively



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