PARACETAMOL, BASIC USE OF MEDICINE, PHARMACOLOGY, MECHANISM, WORKING, COMBINATION, SIDE-EFFECT,DOSE
Channel: PHARMAROCKS THE WAY OF SUCCESS
Date: 2021-01-10

PARACETAMOL
Paracetamol is a class of drug that mainly include as analgesic & antipyretic
ANTIPYRETIC MEDICINE
Drug used to prevent or reduce fever.
ANALGESICS MEDICINE
Drug to reduce or prevent pain sensations
Thus paracetamol use to treat fever as well reduce pain sensations

PARACETAMOL
Paracetamol = N-acetyl-para-aminophenol
Formula C8H9NO2
Bioavailability 63–89%
Protein binding 10–25%
Metabolism Predominantly in the liver
Elimination half-life 2–2.5 hours 
Excretion Urine (85–90%)

PARACETAMOL
ONSET OF ACTION 
Reduce the fever and pain sensation in our body
Pain relief onset by route:
By mouth – 35-40 minutes
Buccal – 15-20 minutes
Intravenous – 8-10  minutes

PARACETAMOL MECHANISM
The exact mechanism of action of acetaminophen is not known.
Acetaminophen may inhibit the nitric oxide (NO) pathway mediated by a variety of neurotransmitter receptors including N-methyl-D-aspartate (NMDA) and substance P, resulting in elevation of the pain threshold
It may reduce the production of prostaglandins in the brain

PARACETAMOL POPULAR COMBINATIONS
Paracetamol 500mg, caffeine 25mg
Paracetamol 500mg,domperidone 10mg
Paracetamol 325mg, codeine phos 30mg
Aceclofenac 100 mg, Paracetamol 325 mg
Paracetamol 500mg +diphenydramine 25mg + phenylepherine hcl 5mg+ Caffeine 30mg
Paracetamol/Phenylephrine 500+12.2mg 

POPULAR DOSAGE FORM FOR FEVER

PARACETAMOL AS SUSPENSION
Paracetamol is a common painkiller for children. 
It's often used to treat headaches, stomach ache, earache, and cold symptoms. 
It can also be used to bring down a high temperature (fever). 
It's available as a syrup OR Suspension. 

PARACETAMOL AS INFUSION
Paracetamol 10mg/ml Solution for Infusion is used as an analgesic. 
(relieves pain) and an antipyretic (lowers fever). 
It is used for: • short-term treatment of moderate pain, especially following surgery.

PARACETAMOL SIDE EFFECTS
An allergic reaction, which can cause a rash and swelling.
Liver damage (hepatotoxicity)
flushing, low blood pressure and a fast heartbeat – this can sometimes happen when paracetamol is given in hospital into a vein in your arm.
Dark urine, clay-colored stools


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