Dehydroepiandrosterone | Wikipedia audio article
Channel: wikipedia tts
Date: 10/12/2018

This is an audio version of the Wikipedia Article:
Dehydroepiandrosterone


00:00:44 1 Biological function
00:00:54 1.1 As an androgen
00:01:52 1.2 As an estrogen
00:02:14 1.3 As a neurosteroid
00:02:30 2 Biological activity
00:02:39 2.1 Hormonal activity
00:02:48 2.1.1 Androgen receptor
00:03:10 2.1.2 Estrogen receptors
00:03:42 2.1.3 Other nuclear receptors
00:03:51 2.2 Neurosteroid activity
00:05:05 2.2.1 Neurotransmitter receptors
00:05:15 2.2.2 Neurotrophin receptors
00:06:07 2.2.3 Microtubule-associated protein 2
00:06:16 2.3 Other activity
00:06:30 2.3.1 G6PDH inhibitor
00:06:50 2.3.2 Miscellaneous
00:07:00 3 Biochemistry
00:08:41 3.1 Biosynthesis
00:08:52 3.1.1 Increasing endogenous production
00:09:32 3.2 Distribution
00:09:45 3.3 Metabolism
00:10:02 3.3.1 Pregnancy
00:10:50 3.4 Levels
00:10:58 3.5 Measurement
00:11:06 4 Chemistry
00:11:16 4.1 Isomers
00:11:28 5 Clinical Applications in Human Reproduction
00:12:33 6 History
00:12:43 7 References
00:13:23 8 Further reading
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SUMMARY
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Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone. It is one of the most abundant circulating steroids in humans, in whom it is produced in the adrenal glands, the gonads, and the brain. It functions as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex steroids both in the gonads and in various other tissues. However, DHEA also has a variety of potential biological effects in its own right, binding to an array of nuclear and cell surface receptors, and acting as a neurosteroid and modulator of neurotrophic factor receptors.In the United States, DHEA is sold as an over-the-counter supplement, and medication, called prasterone.