Compartmental Models in Pharmacokinetics
Channel: Liam Skoda
Date: 2023-12-09

This lecture aims to provide a conceptual overview of the use of compartmental models in pharmacology, with particular reference to 3 compartment models for fentanyl, propofol and midazolam. The video features a practical hydraulic model of fentanyl distribution and elimination and discussion of how these models can guide therapy in critical care environments. 

Slides and animations are my own work and free for reuse (suggest using 4K version). Content developed during preparation for CICM primary exam. 

References and Further Reading (Social Media): 
Ketamine Nightmares: https://ketaminenightmares.com/
Channel:  @ketaminenightmares403

Deranged Physiology: https://derangedphysiology.com/main/home

ICU Primary Prepcast: 
Apple: https://podcasts.apple.com/au/podcast/icu-primary-prepcast/id1378096428
Libsyn: https://primprepcast.libsyn.com/

Articles:
Clearance Review, Bathtub Model: https://doi.org/10.12793/tcp.2015.23.2.42
3 Compartment Solution: https://doi.org/10.12793/tcp.2019.27.2.73
“Fentanyl Challenge”: https://doi.org/10.1213/01.ANE.0000156563.25878.19
Propofol Review: https://doi.org/10.1007/s40262-018-0672-3

AF ECG from Life in the Fast Lane (edited): https://litfl.com/atrial-fibrillation-ecg-library/

Outline: 
00:00:00 Opening
00:00:21 Pharmacokinetics
00:01:52 Hydraulic Analogy
00:13:19 Amiodarone Case
00:16:25 2-Compartment Model
00:18:24 Compartmental Models
00:25:25 Practical 3-Compartment Model
00:30:43 Scaling Models
00:33:44 Low-Clearance
00:34:53 High-Clearance
00:36:03 Fentanyl Infusion Case
00:44:26 Model Fidelity
00:46:29 Fentanyl 3-Compartment Model
00:48:48 Midazolam 3-Compartment Model
00:49:32 Propofol 3-Compartment Model
00:52:24 Context Sensitive Half-Time
00:54:19 References and Further Reading