Norethisterone | Wikipedia audio article
Channel: wikipedia tts
Date: 29/10/2018

This is an audio version of the Wikipedia Article:
Norethisterone

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SUMMARY
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Norethisterone, also known as norethindrone and sold under the brand names Aygestin and Primolut N among many others, is a progestin medication which is used in birth control pills, menopausal hormone therapy, and for the treatment of gynecological disorders. The medication available in both low-dose and high-dose formulations and is used and formulated both alone and in combination with an estrogen. It is taken by mouth.Side effects of norethisterone include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others. Norethisterone is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has weak androgenic and estrogenic activity, mostly at high dosages, and no other important hormonal activity.Norethisterone was discovered in 1951 and was one of the first progestins to be developed. It was first introduced for medical use on its own in 1957 and was introduced in combination with an estrogen for use as a birth control pill in 1963. It is sometimes referred to as a "first-generation" progestin. Along with desogestrel, it is one of the only progestins that is widely available as a progestogen-only "mini pill" for birth control. Norethisterone is marketed widely throughout the world. It is available as a generic medication.In addition to norethisterone itself, a variety of prodrugs of norethisterone, such as norethisterone acetate (NETA) and norethisterone enanthate (NETE) among others, have been marketed and have similar effects and uses. NETA is taken by mouth similarly to norethisterone, while NETE is given by injection into muscle. Many derivatives of norethisterone, such as levonorgestrel and desogestrel, have also been developed and marketed.