Sulfonamide (chemistry) | Wikipedia audio article
Channel: wikipedia tts
Date: 03/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Sulfonamide


00:01:18 1 Synthesis
00:02:08 2 Sultams
00:03:02 3 Sulfinamides
00:03:33 4 Disulfonimides
00:04:01 5 See also



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SUMMARY
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In chemistry, the sulfonamide functional group (also spelled sulphonamide) is -S(=O)2-NH2, a sulfonyl group connected to an amine group.  Relatively speaking this group is unreactive.  The amine center is no longer basic.  The S-N bond is cleaved only with difficulty.  Because of the rigidity of the functional group, sulfonamides are typically crystalline.  For this reason, the formation of a sulfonamide is a classic method to convert an amine into a crystalline derivative which can be identified by its melting point.  Many important drugs contain the sulfonamide group.A sulfonamide (compound) is a compound that contains this group. The general formula is RSO2NH2, where R is some organic group. For example, "methanesulfonamide" is CH3SO2NH2. Any sulfonamide can be considered as derived from a sulfonic acid by replacing a hydroxyl group with an amine group. In medicine, the term "sulfonamide" is sometimes used as a synonym for sulfa drug, a derivative or variation of sulfanilamide. The first sulfonamide was discovered in Germany in 1932.