How to Breakdown a Question | USMLE Step 1 | Cardio
Channel: MedSmarter
Date: 10/02/2022

How to break down a USMLE Step 1 question, from MedSmarter with Dr. Jason Colip.

The attached video is the breakdown of another Cardio question.

We break down the concepts in simple terms in shorter videos so students can focus on the Educational Objective to get a deep understanding of the concept.

A 47-year-old woman with diabetes mellitus receives the results of a fasting lipid profile that reveals hypercholesterolemia. To reduce the patient’s mortality risk, her physician recommends lifestyle changes and initiates therapy with atorvastatin. Which of the following mechanisms describes the action of atorvastatin in reducing serum levels of LDL cholesterol? 

A) Positive feedback to increase 3-hydroxy-3-methylglutaryl coenzyme A lyase activity
B) Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase 
C) Inactivation of 3-hydroxy-3-methylglutaryl coenzyme A synthase 
D) Negative feedback to decrease thiolase activity 
E) Noncompetitive inhibition of citrate synthase 

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Jason Colip, MD - USMLE Instructor
AUIS Alumni
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