BCM theory | Wikipedia audio article
Channel: wikipedia tts
Date: 30/12/2018

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/BCM_theory


00:01:38 1 Development
00:04:41 2 Theory
00:13:09 3 Experiment
00:15:48 4 Applications



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SUMMARY
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BCM theory, BCM synaptic modification, or the BCM rule, named for Elie Bienenstock, Leon Cooper, and Paul Munro, is a physical theory of learning in the visual cortex developed in 1981. Due to its successful experimental predictions, the theory is arguably the most accurate model of synaptic plasticity to date.
The BCM model proposes a sliding threshold for Long-term potentiation (LTP) or Long-term depression (LTD) induction, and states that synaptic plasticity is stabilized by a dynamic adaptation of the time-averaged postsynaptic activity. According to the BCM model, when a pre-synaptic neuron fires, the post-synaptic neurons will tend to undergo LTP if it is in a high-activity state (e.g., is firing at high frequency, and/or has high internal calcium concentrations), or LTD if it is in a lower-activity state (e.g., firing in low frequency, low internal calcium concentrations). This theory is often used to explain how cortical neurons can undergo both LTP or LTD depending on different conditioning stimulus protocols applied to pre-synaptic neurons (usually high-frequency stimulation, or HFS, for LTP, or low-frequency stimulation, LFS, for LTD).