T cells differentiation and maturation | Cellular component | Immunology | First Aid lectures|Lec.7
Channel: Dr. Jamil Lectures
Date: 25/03/2022

In this lecture we will discuss about  Tcell differentiation and maturation, positive selection, negative selevtion, T cell subsets, double positive and double negative T cell, cytotoxic T cells, helper T cell, Th1, Th2, Th17, Treg

https://youtu.be/FmzD6RdFFZs
https://youtu.be/r9yQe_u8keQ
https://youtu.be/aP06bUvyqCA

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T cells are produced in bone marrow and gets mature in thymus by positive and negative selection. 
Positive selection occurs in thymic cortex, T cells expressing TCRs whivh are  capable of bindind self-MHC on cortical epothelial cells that survive.
Negative selection occurs in thymic medulla, here the T cells that express TCRs with high affinity for self antigens will undergo apoptosis or they will become regulatory T cells. 
AIRE gene is respomsible for formation of self antigen, the problem in AIRE gene may cause autoimmune polyendocrine syndrome.
1-Chronic mucocutaneous candidiasis, hypoparathroidism, adrenal insifficiency, recurrent candida infections

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