Biobreeding rat | Wikipedia audio article
Channel: wikipedia tts
Date: 04/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Biobreeding_rat


00:01:28 1 History
00:02:19 2 Modulation of diabetes
00:02:43 3 See also



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SUMMARY
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Biobreeding rat also known as the BB or BBDP rat is an inbred laboratory rat strain that spontaneously develops autoimmune Type 1 Diabetes. Like the NOD mice, BB rats are used as an animal model for Type 1 diabetes. The strain re-capitulates many of the features of human type 1 diabetes, and has contributed greatly to the research of T1D pathogenesis.Two T1D susceptibility genes have been identified in the BB rat.  The susceptible MHC class II RT1u haplotype on chromosome 20  and a null mutation in the GIMAP5 gene on chromosome 4.  The Gimap5 mutation results in severe T cell lymphopenia in the BB rat and is thought to contribute to T1D pathogenesis through impaired development and function and regulatory T cells.  Recently, 8 additional loci on rat chromosomes 1,2,3,6 (2 loci), 12 and 14 have been shown to be linked to Type 1 Diabetes in the BB rat.