Osmotic Engine Model
Channel: Johns Hopkins Institute for NanoBioTechnology
Date: 2014-04-29

In this video, Johns Hopkins University professors Konstantinos Konstantopoulos and Sean Sun, and postdoctoral fellow, Kim Stroka, explain how cells use "directed water permeation" to migrate through tight spaces. They present an integrated experimental and theoretical approach ("Osmotic Engine Model") and demonstrate that directed water permeation is a major mechanism of cell migration in confined microenvironments. The video was produced by Johns Hopkins Institute for NanoBioTechnolgy (INBT) for the journal CELL. Faculty involved are members of the Johns Hopkins Physical Sciences-Oncology Center and INBT. The related paper can be found at this link. http://www.ncbi.nlm.nih.gov/pubmed/24726433