Microgenomics 2021: Spatiotemporal dynamics of ischemic brain injury resolved at single-cell level
Channel: The International Symposium on Microgenomics 2023
Date: 25/01/2022

Lucas Valihrach (Czech Academy of Sciences, Czech Republic): "Spatiotemporal dynamics of ischemic brain injury resolved at single-cell level"

Ischemic brain injury (stroke) is second leading cause of death and primary cause of long-term disability. Pathophysiology of ischemic stroke is complex and involves interaction of large number of cell types in time- and space-dependent manner. A better understanding of the cellular and spatial heterogeneity is therefore crucial for understanding of stroke pathobiology and development of effective treatment strategies. In this webinar, we will present results of analysis of ischemic brain injury in mouse model using the state-of-art methods for single-cell and spatial transcriptomic analysis. The analysis provides unique insight on the processes and cell-types involved in pathogenesis of ischemia with spatial, temporal and single-cell resolution.