Necessary But Not Sufficient (song by Science Groove)
Channel: Greg Crowther
Date: 2012-02-28

A musical summary of the control of glycolysis in contracting skeletal muscle according to two studies published by G.J. Crowther et al. in the American Journal of Physiology (2002). The song is reminiscent of the style of Air Supply and Jim Steinman. Lyrics for this song, and information on all of Greg's other science songs: http://faculty.washington.edu/crowther/Misc/Songs/. More on Do Peterson: http://dopetersun.com.

[lyrics:]

The muscle starts to pull its load, but glucose use is slow
Because [Pi] and [ADP] and [AMP] are low.

CHORUS:
Necessary but not sufficient:
Something's there and yet something's missin',
And the textbook authors sure will be surprised.
High metabolites? Not sufficient.
Muscles pulling tight? Not sufficient.
The two must coexist for flux to rise.

Contraction ends, and once again, the glucose use subsides.
This sudden drop cannot be stopped by high metabolites.

CHORUS