Centrifugal micro-fluidic biochip | Wikipedia audio article
Channel: wikipedia tts
Date: 03/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Centrifugal_micro-fluidic_biochip


00:02:24 1 History
00:04:46 2 Structure design
00:05:39 2.1 Principle
00:09:20 2.2 Typical component
00:09:44 2.2.1 Valves
00:11:53 2.2.2 Volume metering
00:12:22 2.2.3 Mixing
00:13:04 2.2.4 Flow switching
00:13:40 2.2.5 Others
00:14:09 3 Materials
00:16:17 4 Detection
00:16:26 4.1 Signal sending
00:16:35 4.1.1 Sample preparation
00:17:39 4.1.2 ELISA/FIA
00:19:41 4.1.3 Nucleic acid analysis
00:21:39 4.2 Signal receiving
00:23:39 4.2.1 ERD
00:25:13 4.2.2 AAS
00:26:04 5 See also



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SUMMARY
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The centrifugal micro-fluidic biochip or centrifugal micro-fluidic biodisk is a type of lab-on-a-chip technology, also known as lab-on-a-disc, that can be used to integrate processes such as separating, mixing, reaction and detecting molecules of nano-size in a single piece of platform, including a compact disk or DVD. This type of micro-fluidic biochip is based upon the principle of microfluidics; to take advantage of noninertial pumping for lab-on-a-chip devices using noninertial valves and switches under centrifugal force and Coriolis effect to distribute fluids about the disks in a highly parallel order.
This biodisk is an integration of multiple technologies in different areas. The designer must be familiar with the process of biology testing before designing the detailed micro-structures in the compact disk. Some basic element components such as valves, mixing units, and separating units should all be used to complete the full testing process. The most basic principles applied in such micro-fluidic structures are centrifugal force, coriolis effect, and surface tension. The micromachining techniques, including patterning, photolithography, and etching should all be used as long as the design is verified. Once the testing process is successful in the biodisk, the complex detection technique is started. There are many methods proposed by scientists in this area. The most popular method is immunoassay which is widely use in the testing of biology. The final step is receiving data from the biodisk by means of a CD drive and modifying either software or hardware that can achieve this function. A popular method is reading data from the biodisk using a common CD drive with some developed software, which contains the advantage of being low on cost.
Once the centrifugal micro-fluidic biochip is developed well enough to be manufactured on a large scale, it will cause a wide effect on the industry as well as medical care, especially in developing countries, where high-precision equipment is not available.  People in developed countries who are willing to do such regular home-care detections can also benefit from this new technology.