Ribosome biogenesis | Wikipedia audio article
Channel: wikipedia tts
Date: 05/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Ribosome_biogenesis


00:01:18 1 Ribosomes
00:02:08 2 Prokaryotes
00:03:56 3 Eukaryotes
00:05:12 3.1 Processing
00:07:52 3.2 40S subunit
00:10:04 3.3 60S subunit
00:13:21 4 Nuclear export
00:14:47 5 Quality control
00:16:40 6 Human disease



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SUMMARY
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Ribosome biogenesis is the process of making ribosomes.  In prokaryotes, this process takes place in the cytoplasm with the transcription of many ribosome gene operons.  In eukaryotes, it takes place both in the cytoplasm and in the nucleolus. It involves the coordinated function of over 200 proteins in the synthesis and processing of the three prokaryotic or four eukaryotic rRNAs, as well as assembly of those rRNAs with the ribosomal proteins. Most of the ribosomal proteins fall into various energy-consuming enzyme families including ATP-dependent RNA helicases, AAA-ATPases, GTPases, and kinases. About 60% of a cell's energy is spent on ribosome production and maintenance.Ribosome biogenesis is a very tightly regulated process, and it is closely linked to other cellular activities like growth and division.Some have speculated that in the origin of life, ribosome biogenesis predates cells, and that genes and cells evolved to enhance the reproductive capacity of ribosomes.