Type 1 hypersensitivity | Immunology | First Aid Lectures | Lec22 #drjamillectures #drjameellectures
Channel: Dr. Jamil Lectures
Date: 2022-04-08

In this lecture we will discuss about hypersensitivity type 1,sensitization,desensitization,Anaphylactic ,atopy,drug hypersensitivity immediate and late phase immune response.

https://youtu.be/rKZRQWWmBsI
https://youtu.be/4gKanyASW1E
https://youtu.be/aP06bUvyqCA

Instagram account   dr_jamil56

Type 1 hypersensitivity
Anaphylactic and atopic—two phases:
 Immediate (minutes): 
antigen crosslinks preformed IgE on presensitized mast cells 
 immediate degranulation 
 release of histamine (a vasoactive amine) and tryptase (a marker of mast cell activation).
 Late (hours): 
chemokines (attract inflammatory cells, eg, eosinophils) and other mediators (eg, leukotrienes) from mast cells  inflammation and tissue damage.
Test: 
skin test or blood test (ELISA) for allergenspecific IgE.
Example:
 Anaphylaxis (eg, food, drug, or bee sting 
allergies)
 Allergic asthma

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