Separation of Four Stereoisomers of LuliconazoleUsing Supercritical Fluid Chromatography CERChE-2021
Channel: Chitkara University Publications
Date: 01/03/2021

Separation of Four Stereoisomers of Luliconazole Using Supercritical Fluid Chromatography: Thermodynamic Aspects and Simulation Study with Chiral Stationary Phase  
Priyanka A. Shah, Pranav A. Pandya, Pranav S. Shrivastav*Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad- 380009, India


Abstract   
The work describes a novel supercritical fluid chromatography method for the separation of four stereoisomers, RZ(+), SZ(-), RE(+), and SE(-) of luliconazole, an antifungal agent on amylose tris[(S)-α-methyl benzyllcarbamate] based Chiralpak IH column.  keywords: Chiral supercritical fluid chromatography; Luliconazole; Stereoisomers; Organic modifier; Thermodynamics; Molecular docking