Biological half-life | Wikipedia audio article
Channel: wikipedia tts
Date: 27/12/2018

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Biological_half-life


00:01:09 1 Examples
00:01:19 1.1 Water
00:02:00 1.2 Alcohol
00:03:10 1.3 Common prescription medications
00:03:21 1.4 Metals
00:05:19 1.5 Peripheral half-life
00:05:44 2 Rate equations
00:05:54 2.1 First-order elimination
00:08:55 2.2 Biphasic half-life
00:09:44 3 Sample values and equations
00:09:55 4 See also



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SUMMARY
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The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential. It is often denoted by the abbreviation 
  
    
      
        
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    {\displaystyle t_{\frac {1}{2}}}
  . Examples include metabolites, drugs, and signalling molecules. Typically, this refers to the body's cleansing through the function of kidneys and liver in addition to excretion functions to eliminate a substance from the body. In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve (plasma half-life) its steady-state. The relationship between the biological and plasma half-lives of a substance can be complex depending on the substance in question, due to factors including accumulation in tissues (protein binding), active metabolites, and receptor interactions.