Aceclofenac 100mg, 200mg, Tablet In Bangladesh   Uses, Dosage, Side Effects, Interactions, Pregnancy
Channel: Rx Harun
Date: 14/03/2021

Aceclofenac 100mg, 200mg, Tablet In Bangladesh   Uses, Dosage, Side Effects, Interactions, Pregnancy. Aceclofenac potently inhibits the cyclooxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is orally administered for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Aceclofenac belongs to BCS Class II as it possesses poor aqueous solubility.
Indications Of Aceclofenac
Aceclofenac tablet is used for the treatment, control, prevention, & improvement of the following diseases, conditions, and symptoms
Indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Muscles stiffness in spinal
Muscles stiffness in muscle diseases
Muscles stiffness in the joint diseases
Lumbago
Low back pain
PLID
Frozen shoulder
Ankylosing spondylitis
Pain caused by nonarticular rheumatism
Muscles stiffness in nerve diseases
Rheumatoid arthritis
Osteoarthritis
Cervical spondylosis
Periarthritis of scapulohumeral
Ischiadynia
a backache
Teething
Contra-Indications Of Aceclofenac
Hypersensitivity to  Aceclofenac Tablet is a contraindication. In addition, Aceclofenac Tablet should not be used if you have the following conditions
Active peptic ulcer
Acute rhinitis
Allergic to thiocolchicoside
Asthma
Breastfeeding
Pregnant
Urticaria
Concurrent peptic ulcer, or history of ulcer disease
Allergy to indometacin, aspirin, or other NSAIDs
Patients with nasal polyps reacting with an angioedema to other NSAIDs
Children under 2 years of age (with the exception of neonates with patent ductus arteriosus)
Some painkillers, including opioid pain killers;
Hypnotic drugs;
Psychotropic drugs;
Used monoamine oxidase inhibitors (MAOIs) such as phenelzine or tranylcypromine
Epilepsy;
Addiction or are recovering from addiction to another medication.
History of peptic ulcer disease,
Gastrointestinal bleeding,
Severe pre-existing renal and liver damage
Caution: pre-existing bone marrow damage (frequent blood cell counts are indicated)
Caution: bleeding tendencies of unknown origin
Caution: Parkinson’s disease, epilepsy, psychotic disorders (indometacin may worsen these conditions)
Concurrent with potassium sparing diuretics
Patients who have a patent ductus arteriosus dependent heart defect (such as transposition of the great vessels)
Dosage Of Aceclofenac 
Strengths : 100 mg , 200 mg

Ankylosing Spondylitis
100 mg bid, in the morning and in the evening.
Rheumatoid Arthritis
100 mg bid, in the morning and in the evening.
Osteoarthritis
100 mg bid, in the morning and in the evening.
Side Effects Of Aceclofenac
The most common

GI disorders (e.g. dyspepsia, abdominal pain, nausea, vomiting, diarrhoea, flatulence, constipation,, ulcerative stomatitis, ), indigestion,
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain.
Drowsiness and lightheadedness
Nausea and vomiting
joint pain
Nausea and vomiting
Severe stomach ache
Severe diarrhea
Vaginal thrush
Skin rash
Headache
Chest pain
Diarrhea or loose stools
Difficulty with breathing
Dizziness
Heartburn
Muscle pain
Drug Interactions Of Aceclofenac
Aceclofenac may interact with following drugs, supplyments & may change the efficacy of drugs

antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
 (ACEIs; e.g., captopril, enalapril, ramipril)
angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
beta-adrenergic blockers (e.g., metoprolol, atenolol)
Pregnancy& Lactation Of Aceclofenac
FDA Pregnancy Category C 
References

http://www.drugbank.ca/drugs/DB06736
http://www.drugbank.ca/drugs/DB06736#targets
http://www.drugbank.ca/drugs/DB06736#enzymes
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