15β-Hydroxycyproterone acetate | Wikipedia audio article
Channel: wikipedia tts
Date: 2018-10-29

This is an audio version of the Wikipedia Article:
15β-Hydroxycyproterone acetate

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SUMMARY
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15β-Hydroxycyproterone acetate (15β-OH-CPA) is a steroidal antiandrogen and the major metabolite of cyproterone acetate which is formed from it in the liver by hydroxylation via the cytochrome P450 enzyme CYP3A4. It circulates at concentrations that are approximately twice those of CPA. In addition, it has similar or even greater antiandrogen activity relative to CPA but only about one-tenth of its activity as a progestogen. It also shows some glucocorticoid activity similarly to cyproterone acetate and unesterified cyproterone.