CH450 Chapter 7.2 and 7.3 Catalytic Mechanisms of Enzymes: Chymotrypsin
Channel: Patricia Flatt
Date: 2020-10-27

In this lecture, we discuss the major catalytic strategies that enzymes use to facilitate chemical reactions. Catalytic strategies include covalent catalysis, acid-base catalysis, electrostatic catalysis, desolvation, catalysis by approximation, coenzyme catalysis, and strain distortion. The reaction mechanism of chymotrypsin is detailed as an example of covalent catalysis, acid-base catalysis, desolvation, and electrostatic catalysis.