Genomic biology | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-06-07

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Genomics


00:01:11 1 History
00:01:19 1.1 Etymology
00:01:59 1.2 Early sequencing efforts
00:03:13 1.3 DNA-sequencing technology developed
00:04:55 1.4 Complete genomes
00:08:03 1.5 The "omics" revolution
00:09:03 2 Genome analysis
00:09:25 2.1 Sequencing
00:10:07 2.1.1 Shotgun sequencing
00:12:16 2.1.2 High-throughput sequencing
00:14:23 2.2 Assembly
00:15:08 2.2.1 Assembly approaches
00:16:00 2.2.2 Finishing
00:16:15 2.3 Annotation
00:17:52 2.4 Sequencing pipelines and databases
00:18:11 3 Research areas
00:18:20 3.1 Functional genomics
00:19:27 3.2 Structural genomics
00:20:51 3.3 Epigenomics
00:21:40 3.4 Metagenomics
00:22:43 3.5 Model  systems
00:22:51 3.5.1 Viruses and bacteriophages
00:24:00 3.5.2 Cyanobacteria
00:25:16 4 Applications of genomics
00:25:33 4.1 Genomic medicine
00:26:11 4.2 Synthetic biology and bioengineering
00:26:38 4.3 Conservation genomics



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SUMMARY
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Genomics is an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes. A genome is an organism's complete set of DNA, including all of its genes. In contrast to genetics, which refers to the study of individual genes and their roles in inheritance, genomics aims at the collective characterization and quantification of all of an organism's genes, their interrelations and influence on the organism. Genes may direct the production of proteins with the assistance of enzymes and messenger molecules. In turn, proteins make up body structures such as organs and tissues as well as control chemical reactions and carry signals between cells. Genomics also involves the sequencing and analysis of genomes through uses of high throughput DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes. Advances in genomics have triggered a revolution in discovery-based research and systems biology to facilitate understanding of even the most complex biological systems such as the brain.The field also includes studies of intragenomic (within the genome) phenomena such as epistasis (effect of one gene on another), pleiotropy (one gene affecting more than one trait), heterosis (hybrid vigour), and other interactions between loci and alleles within the genome.