Tumor microenvironment | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-06-15

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Tumor_microenvironment


00:00:40 1 History
00:03:28 2 Vasculature
00:04:05 2.1 Enhanced permeability and retention effect
00:04:51 2.2 Hypoxia
00:06:50 3 Reactive stromal cells
00:07:32 3.1 Carcinoma associated fibroblasts
00:09:59 3.2 Myeloid-derived suppressor cells and tumor associated macrophages
00:12:22 3.3 Neutrophils
00:13:36 3.4 Tumor infiltrating lymphocytes
00:14:38 3.5 Extracellular matrix remodeling
00:17:34 3.6 Relation to T cells
00:21:34 3.6.1 Reproduction
00:26:04 3.6.2 Apoptosis
00:26:43 3.6.3 TAMs and MDSCs
00:29:13 3.6.4 Spatial distribution
00:31:17 4 Clinical implications
00:31:28 4.1 Drug development
00:33:15 4.2 Therapies
00:33:24 4.2.1 Antibodies
00:34:44 4.2.2 Kinase inhibitors
00:35:52 4.2.3 Liposomes
00:36:53 5 See also



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SUMMARY
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The tumor microenvironment (TME) is the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules and the extracellular matrix (ECM). The tumor and the surrounding microenvironment are closely related and interact constantly. Tumors can influence the microenvironment by releasing extracellular signals, promoting tumor angiogenesis and inducing peripheral immune tolerance, while the immune cells in the microenvironment can affect the growth and evolution of cancerous cells.