Can Tsunade wield the Rinnegan?
Channel: VerseTube
Date: 2024-03-10

There is Tsunaday’s unknown parent in the middle who should have been monster (who should have no trouble wielding a pair of transplanted Rinnegan) but considering Tsunaday’s showings, she has some of the highest Chakra reserves in the series.

And a strong life force, allowing her to live longer and summon Katsuyu for a considerable amount of time.

Staying conscious for the whole time and healing the other heavily injured Ka-gay (albeit slowly) at the same time after getting bisected by Edo Madara until the Orochimaru squad arrived and helped.
She was good to go after receiving Karin's healing chakra.
Nagato was considered to be of Senju lineage by Madara and Zetsu — his Mother being an Uzumaki — which enabled him to wield Madara’s pair of rinnegan.
And dude, like Naruto was half Uzumaki at best.
There is nothing stated that his father was also of Uzumaki or Senju descendant which means just one parent of Uzumaki descendant was enough for him to wield a pair of rinnegan, however, even he shortened his life on numerous occasions (besides ending up as a cripple) due to the Rinnegan
In my opinion, Tsunaday should be capable of wielding at least one Rinnegan if not both.
However, she most likely — definitely — wouldn’t have reached her current age.