What is the depression
Channel: Depression Defeat
Date: 2023-07-17

Major depressive disorder is a mental illness with symptoms that affect a person's thoughts, feelings, and behavior. Depression is widespread but poorly understood. This video provides an overview of what depression actually is including a discussion of symptoms, causes, and treatment.
Depression is on a continuum. Severe depression is often overlooked or misconstrued. It is not the same as low-grade depression. 

For many people, depression is one of the most disabling illnesses we have in society. Despite the treatments that we have available, many people are not responding that well. It's a disorder that can be very disabling in society. It's also a disorder that has medical consequences. By understanding the neurology of depression, we hope to find the right treatment for the patient suffering from this disease.  The current standard of care for the treatment of depression is based on what we call the monoamine deficiency hypothesis. Essentially, presuming that one of three neurotransmitters in the brain is deficient or underactive. But the reality is, there are more than 100 neurotransmitters in the brain. And billions of connections between neurons. 

So we know that that's a limited hypothesis. Neurotransmitters can be thought of as the chemical messengers within the brain, it's what helps one cell in the brain communicate with another, to pass that message along from one brain region to another. For decades, we thought that the primary pathology and cause of depression was some abnormality in these neurotransmitters, specifically serotonin or norepinephrine. However, epinephrine and serotonin did not seem to be able to account for this cause or to cause the symptoms of depression in people who had major depression. Instead, the chemical messengers between the nerve cells in the higher centers of the brain, which include amalgamate and GABA, were possibilities as alternative causes for the symptoms of depression. 
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