Ischemia-reperfusion injury of the appendicular musculoskeletal system | Wikipedia audio article
Channel: wikipedia tts
Date: 03/05/2019

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Ischemia-reperfusion_injury_of_the_appendicular_musculoskeletal_system


00:00:52 1 Definitions
00:01:07 2 Mechanisms and Basic science
00:01:16 2.1 IR and biomarkers
00:01:49 2.2 IR and Epigenetics
00:01:58 2.3 IR and stem cells
00:02:31 3 Clinical implications
00:03:31 4 Tourniquets
00:06:02 5 Treatment approaches



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SUMMARY
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Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation.  IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. Whether resulting from traumatic vessel disruption, tourniquet application, or shock, the extremity is exposed to an enormous flux in vascular perfusion during a critical period of tissue repair and regeneration. The contribution of this ischemia and subsequent reperfusion on post-traumatic musculoskeletal tissues is unknown; however, it is likely that similar to cardiac and kidney tissue, IR significantly contributes to tissue fibrosis.