SUPPOSITORY BASE, PART-5, EMULSIFYING BASES, SYNTHETIC BASES, WITEPSOL, MASSA ESTERIUM, MASSUPPOL,
Channel: PHARMAROCKS THE WAY OF SUCCESS
Date: 2021-03-29

#SUPPOSITORIES, 
Suppositories are semi-solid dosage forms intended for insertion into body orifices 
Like rectum, vagina, urethra where they melt, soften, or dissolve at body temperature and provide a local or systemic effect to treat various diseases.

WHAT IS SUPPOSITORIES BASE?
Suppository base excipients are used in the manufacture of suppositories.
They can be hydrophobic or hydrophilic. 
Suppositories should melt at just below body temperature 37°C
which allows for erosion of the dosage form and release of the API. 
Hard fat suppository bases melt at approximately body temperature.

EMULSIFYING BASES (SYNTHETIC BASES )  
These are synthetic bases and a number of proprietary bases of very good quality are available, few of which are described below: 
Witepsol,
WITEPSOL® H-15,
Massa Esterium,
Massuppol,

#WITEPSOL (WITEPSOL® H-15)
It consists of glycerol esters of vegetable saturated fatty acids, mainly lauric acid and is derived from coconut & palm kernel oils.
They  consist  of  triglycerides  of  saturated  vegetable  acids  (chain  length  C12  to  C18)  with  varying  proportions  of  partial esters.

EMULSIFYING BASES (SYNTHETIC BASES) 
MASSA ESTERIUM: 
This is another range of bases, consisting of a mixture of di-, tri- and mono- glycerides of saturated fatty acids with chain lengths of C11 to C17. 

MASSUPPOL: 
It consists of glyceryl esters mainly of lauric acid, to which a small amount of glyceryl monostearate has been added to improve its water absorbing  capacity.

EMULSIFYING BASES (SYNTHETIC BASES) 
Advantages of these bases over cocoa butter: 
1.  Over heating does not alter the physical characteristics. 
2.  They do not stick to the mould. 
3.  They do not require previous lubrication of the mould  
4.  They solidify rapidly. 
5.  They are less liable to get rancid. 
6.  They can absorb fairly large amount of aqueous liquids.


#SUPPOSITORY_BASE

👨🏼‍🏫 THIS EXPERT LECTURE BY 👨🏼‍🏫

MR AMAR M RAVAL 
ASSISTANT PROFESSOR
FOUNDER PHARMAROCKS
PHD SCOLAR (GTU AHMEDABAD)
☎️ CONTACT: 9016312020

📱 PHARMAROCKS E-LEARNING APP 

📚 STUDY MATERIAL
👨🏼‍🏫 VIDEO LECTURE
📊 TEST SERIES

Available for Android and app iPhone & ipad

📱 ANDROID APP LINK https://play.google.com/store/apps/details?id=co.april2019.pharma

📲 APPLE iPhone LINK
https://apps.apple.com/in/app/my-institute/id1472483563

📝 Org Code for iPhone =  PHARMA

☎️ HELPLINE 9426180836