Biochemical cascade | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-03-29

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Biochemical_cascade


00:00:45 1 Introduction
00:00:55 1.1 Signaling cascades
00:02:05 1.2 Transductors and effectors
00:05:27 1.3 Cellular response
00:07:10 1.4 Examples of biochemical cascades
00:10:11 2 Cell-specific biochemical cascades
00:10:23 2.1 Epithelial cells
00:13:51 2.2 Hepatocytes
00:17:10 2.3 Neurons
00:19:49 2.4 Blood cells
00:23:35 2.5 Lymphocytes
00:28:13 2.6 Bones
00:28:22 2.6.1 Wnt signaling pathway
00:29:52 2.6.2 RANKL/RANK signaling pathway
00:30:35 2.6.3 Adenosine signaling pathway
00:31:37 2.7 Stem cells
00:36:15 2.8 Oocytes
00:39:42 2.9 Spermatozoon
00:43:37 2.10 Embryos
00:47:37 3 Pathway construction
00:50:58 4 Pathway-related databases and tools
00:52:02 4.1 KEGG
00:52:14 4.2 GenMAPP
00:53:50 4.3 Reactome
00:55:55 5 Pathway-oriented approaches
00:59:44 6 Applications of pathway analysis in medicine
01:03:24 6.1 Colorectal cancer (CRC)
01:03:36 6.2 Parkinson's disease (PD)
01:05:47 6.3 Alzheimer's disease (AD)
01:08:05 7 References



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SUMMARY
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A biochemical cascade, also known as a signaling cascade or signaling pathway, is a series of chemical reactions which are initiated by a stimulus (first messenger) acting on a receptor that is transduced to the cell interior through second messengers (which amplify the initial signal) and ultimately to effector molecules, resulting in a cell response to the initial stimulus. At each step of the signaling cascade, various controlling factors are involved to regulate cellular actions, responding effectively to cues about their changing internal and external environments.