BLOOD COAGULATION PART 2/5 | VASOCONSTRICTION | PLATELET ADHESION
Channel: BioScience Classes 
Date: 03/05/2021

In this video lecture we have discussed how a ruptured/injured endothelium of a blood vessel responds in blood coagulation process. The first step is vascular spasm/vasoconstriction of blood vessel which reduces the blood flow. Vasoconstriction occur by three ways: Neurogenic Reflex vasoconstriction, Myogenic vasoconstriction and release of Endothelin by ruptured endothelial cells. In the next step, platelet adhesion starts on exposed sub endothelial surface rich in collagen. VW factor is synthesized and secreted by ruptured endothelial cells which have binding efficiency with both collagen and platelets. Platelets contain a receptor Gp-1b which is specific to VW factor and this binding further activates the platelets resulting in platelet adhesion.




Also watch:

BLOOD COAGULATION PART-1/4 | Anti-coagulant properties of healthy blood vessel endothelium |

https://youtu.be/DxFBmX8CjK8 


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