Protein complex | Wikipedia audio article
Channel: wikipedia tts
Date: 2019-01-18

This is an audio version of the Wikipedia Article:
https://en.wikipedia.org/wiki/Protein_complex


00:01:27 1 Function
00:02:32 2 Types of protein complexes
00:02:42 2.1 Obligate vs non-obligate protein complex
00:03:23 2.2 Transient vs permanent/stable protein complex
00:05:00 2.3 Fuzzy complex
00:05:54 3 Essential proteins in protein complexes
00:07:27 4 Homomultimeric and heteromultimeric proteins
00:08:42 5 Structure determination
00:09:41 6 Assembly
00:10:57 6.1 Evolutionary significance of multiprotein complex assembly
00:11:31 7 See also



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SUMMARY
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A  protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Different polypeptide chains may have different functions. This is distinct from a multienzyme complex, in which multiple catalytic domains are found in a single polypeptide chain.Protein complexes are a form of quaternary structure.  Proteins in a protein complex are linked by non-covalent protein–protein interactions, and different protein complexes have different degrees of stability over time.   These complexes are a cornerstone of many (if not most) biological processes and together they form various types of molecular machinery that perform a vast array of biological functions.  The cell is seen to be composed of modular supramolecular complexes, each of which performs an independent, discrete biological function.Through proximity, the speed and selectivity of binding interactions between enzymatic complex and substrates can be vastly improved, leading to higher cellular efficiency.  Many of the techniques used to break open cells and isolate proteins are inherently disruptive to such large complexes, so it is often difficult to determine the components of a complex.  Examples of protein complexes include the proteasome for molecular degradation and most RNA polymerases.  In stable complexes, large hydrophobic interfaces between proteins typically bury surface areas larger than 2500 square Ås.