QTL mapping and GWAS (Bioinformatics S8E1)
Channel: Danny Arends
Date: 16/12/2021

Learn about phenotypes, heritability, homologous recombination, genetic linkage, and experimental (multi parental) crosses used in QTL analysis. This lecture is an introduction into Quantitative Trait Locus QTL mapping and genome-wide association analysis GWAS. 

This is a live-stream recording of the MSc and PhD lecture series: Bioinformatics for plant and animal sciences, given digitally during the Covid19 pandemic at the Humboldt University in Berlin organized and lectured by Dr Danny Arends.

Lectures @ https://dannyarends.nl/bioinformatik/
Programming Assignments and Answers @ https://dannyarends.nl/bioinfo/
Playlist: https://www.youtube.com/playlist?list=PLhR2Go-lh6X5A5WbiO3SPHuoWbwpNznUl

Chapters:
00:00 Welcome and Overview
00:40 A few words about phenotypes
01:24 Quantitative and qualitative phenotypes
03:35 Definition of heritability and environment
05:59 The broad-sense heritability of a phenotype
08:25 The narrow-sense heritability of a phenotype
10:11 Estimating heritability using a selection differential
14:01 Estimating heritability using analysis of variance (ANOVA)
15:50 DNA allows for random composition and mutation of heritable phenotypes 
16:39 Homologous recombination of DNA happens during meiosis 1
24:20 Restriction fragment length polymorphism (RLPF) as genetic markers
28:48 Variable number of tandem repeats (VNTR) as genetic markers
30:55 Single nucleotide polymorphisms (SNPs) and SNP chips
32:36 Quantitative Trait Locus (QTL) mapping
34:05 Types of experimental crosses - The Backcross population
37:50 Drawing to visualize genetic inheritance of a backcross
48:25 Types of experimental crosses - The F2 population
50:32 Types of experimental crosses - Recombinant inbred lines (RILs)
53:59 Overview of different crosses used in QTL mapping
55:12 More complex (multi parental) crosses
56:38 Two flavors of linkage analysis (QTL and GWAS)

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