Type 2 hypersensitivity | Immunology | First Aid Lectures | Lec23 #drjamillectures #drjameellectures
Channel: Dr. Jamil Lectures
Date: 2022-04-09

In this lecture we will discuss about hypersensitivity type 2,cellular destruction by phagocytosis,complement activation and NK cells  antibody dependent cytotoxic killing and examples. Inflammation and examples.Cellelar dysfunction and its examples in type 1 hypersensitivity.


https://youtu.be/3JL7Vqvvylk
https://youtu.be/rKZRQWWmBsI
https://youtu.be/aP06bUvyqCA


Instagram account   dr_jamil56


hypersensitivity type 2
Antibodies bind to cell-surface antigens 
increase cellular destruction, inflammation, and 
cellular dysfunction. 
Direct Coombs test—detects antibodies 
attached directly to the RBC surface.
Indirect Coombs test—detects presence of 
unbound antibodies in the serum.
Cellular destruction—cell is opsonized (coated) 
by antibodies, leading to either:
increase Phagocytosis and/or activation of 
complement system.
increase NK cell killing (antibody-dependent cellular cytotoxicity)
Examples:
 Autoimmune-hemolytic anemia 
 Immune thrombocytopenia 
 Transfusion reactions
 Hemolytic disease of the newborn
Inflammation—binding of antibodies to cell 
surfaces increase activation of complement system 
and Fc receptor-mediated inflammation.
Examples:
 Goodpasture syndrome
 Rheumatic fever
 Hyperacute transplant rejection
Cellular dysfunction—antibodies bind to cell 
surface receptors  abnormal blockade or 
activation of downstream process.
Examples:
 Myasthenia gravis
 Graves disease
 Pemphigus vulgaris


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