Curcumin against Beta Lactamase and L,D–Transpeptidase in Salmonella typhi
Channel: ISCB-SC Webinars
Date: 04/03/2021

Typhoid fever is an acute ailment caused by the Salmonella Typhi bacteria. The existing drugs of typhoid fever started to show resistance and developed multidrug resistance S. Typhi strains. In our country, 113 Salmonella carrying Beta-lactamase and its resistance was found in frozen chicken meat. But the main character behind typhoid fever is L, D–Transpeptidase, which is involved in toxin secretion which causes typhoid fever. In our study, we found that Cyclovalone, a natural ligand can inhibit both of the enzymes. It showed very promising results among 70 ligands. After identifying the proteins, the primary and secondary structures, gene-causing regions were identified and homology modeling was done. Next, drug likely properties of these ligands were retrieved. After molecular docking, ADME/T prediction, pharmacological activity prediction, and p450 site prediction were done. Cyclovalone has antibacterial, efflux pump inhibitor, Beta-lactamase inhibitor properties. This curcumin derivative can be a potential drug as a computational study.