A Comprehensive Account on Physicochemical Properties of Drug in Amino Acid Solutions on CERChE-2021
Channel: Chitkara University Publications
Date: 24/02/2021

Drugs are imperative chemical compounds that have been used for a long time for the recognition, alleviation, and prediction of diseases in the living systems. Rising levels of bacterial resistance to antibiotics are a perpetual and dynamic subject in the discipline of medicine and demand the design and discovery of new and more effective antibiotics. Studies of thermophysical properties such as densities (ρ), viscosities (η) and ultrasonic speeds (u) help the researchers to understand the action of antibiotics in aqueous solution as they exert their activity by interacting with biomolecules like carbohydrates, vitamins, lipids, amino acids, nucleic acids, etc. The interaction of the antibiotic drugs with amino acids as a function of temperature is of great interest as it explains the absorption and transportation of antibiotics across the biological membranes. This can be investigated by volumetric and acoustic tools. The empirical density data of antibiotic in water and aqueous amino acid solutions can be used to evaluate apparent molar volume (Vϕ), limiting apparent molar volume (V0ϕ), transfer volume (∆trV0ϕ), partial molar expansibility (E0ϕ) and Helpers are constant. From ultrasonic velocity data, parameters like isentropic compression (Kϕ,s) and specific acoustic impedance (Z)  can be determined. The derived data is then designated in terms of solute-solute / solute-solvent interactions and structure making/breaking characteristics of antibiotics in aqueous amino acid solutions. Spectroscopic studies like IR and UV are also helpful in analyzing the interactions present in antibiotics and amino acids.
Keywords: - Antibiotic, Apparent molar volume, Expansibility, Isentropic compressibility, IR, UV