Boolean network dynamics: applications and challenges
Channel: Instituto de Física Interdisciplinar y Sistemas Complejos (IFISC)
Date: 02/03/2016

- By: Konstantin Klemm, IFISC
- Date: 2016-03-02 14:30:00
- Description: Boolean networks are coarse-grained models of the regulatory dynamics for survival and proliferation of a living cell. The dynamics is time- and state-discrete. The Boolean abstraction assumes digital information processing. The binary distinction of a low or a high concentration of each bio-molecule is sufficient to capture the dynamics. In the presentation, I offer an introduction to Boolean networks, examples of application to specific biological systems and the mathematical and computational treatment with state transition graphs.

Despite being a drastic simplification w.r.t. systems of coupled differential equations, analysis of specific Boolean networks --- rather than ensemble averages --- poses computational challenges. I present ongoing work on capturing long term dynamics by identifying fixed points and other invariant sets under stochastic asynchronous update.