Reviewerly/exHarmony huggingface dataset:
A generalized deep learning framework for whole-slide image segmentation and analysis

Abstract Histopathology tissue analysis is considered the gold standard in cancer diagnosis and prognosis. Whole-slide imaging (WSI), i.e., the scanning and digitization of entire histology slides, are now being adopted across the world in pathology labs. Trained histopathologists can provide an accurate diagnosis of biopsy specimens based on WSI data. Given the dimensionality of WSIs and the increase in the number of potential cancer cases, analyzing these images is a time-consuming process. Automated segmentation of tumorous tissue helps in elevating the precision, speed, and reproducibility of research. In the recent past, deep learning-based techniques have provided state-of-the-art results in a wide variety of image analysis tasks, including the analysis of digitized slides. However, deep learning-based solutions pose many technical challenges, including the large size of WSI data, heterogeneity in images, and complexity of features. In this study, we propose a generalized deep learning-based framework for histopathology tissue analysis to address these challenges. Our framework is, in essence, a sequence of individual techniques in the preprocessing-training-inference pipeline which, in conjunction, improve the efficiency and the generalizability of the analysis. The combination of techniques we have introduced includes an ensemble segmentation model, division of the WSI into smaller overlapping patches while addressing class imbalances, efficient techniques for inference, and an efficient, patch-based uncertainty estimation framework. Our ensemble consists of DenseNet-121, Inception-ResNet-V2, and DeeplabV3Plus, where all the networks were trained end to end for every task. We demonstrate the efficacy and improved generalizability of our framework by evaluating it on a variety of histopathology tasks including breast cancer metastases (CAMELYON), colon cancer (DigestPath), and liver cancer (PAIP). Our proposed framework has state-of-the-art performance across all these tasks and is ranked within the top 5 currently for the challenges based on these datasets. The entire framework along with the trained models and the related documentation are made freely available at GitHub and PyPi. Our framework is expected to aid histopathologists in accurate and efficient initial diagnosis. Moreover, the estimated uncertainty maps will help clinicians to make informed decisions and further treatment planning or analysis.
High-speed programmable photonic circuits in a cryogenically compatible, visible–near-infrared 200 mm CMOS architecture

Abstract Recent advances in photonic integrated circuits have enabled a new generation of programmable Mach–Zehnder meshes (MZMs) realized by using cascaded Mach–Zehnder interferometers capable of universal linear-optical transformations on N input/output optical modes. MZMs serve critical functions in photonic quantum information processing, quantum-enhanced sensor networks, machine learning and other applications. However, MZM implementations reported to date rely on thermo-optic phase shifters, which limit applications due to slow response times and high power consumption. Here we introduce a large-scale MZM platform made in a 200 mm complementary metal–oxide–semiconductor foundry, which uses aluminium nitride piezo-optomechanical actuators coupled to silicon nitride waveguides, enabling low-loss propagation with phase modulation at greater than 100 MHz in the visible–near-infrared wavelengths. Moreover, the vanishingly low hold-power consumption of the piezo-actuators enables these photonic integrated circuits to operate at cryogenic temperatures, paving the way for a fully integrated device architecture for a range of quantum applications.
RADet: Refine Feature Pyramid Network and Multi-Layer Attention Network for Arbitrary-Oriented Object Detection of Remote Sensing Images

Object detection has made significant progress in many real-world scenes. Despite this remarkable progress, the common use case of detection in remote sensing images remains challenging even for leading object detectors, due to the complex background, objects with arbitrary orientation, and large difference in scale of objects. In this paper, we propose a novel rotation detector for remote sensing images, mainly inspired by Mask R-CNN, namely RADet. RADet can obtain the rotation bounding box of objects with shape mask predicted by the mask branch, which is a novel, simple and effective way to get the rotation bounding box of objects. Specifically, a refine feature pyramid network is devised with an improved building block constructing top-down feature maps, to solve the problem of large difference in scales. Meanwhile, the position attention network and the channel attention network are jointly explored by modeling the spatial position dependence between global pixels and highlighting the object feature, for detecting small object surrounded by complex background. Extensive experiments on two remote sensing public datasets, DOTA and NWPUVHR -10, show our method to outperform existing leading object detectors in remote sensing field.
An annotation-free whole-slide training approach to pathological classification of lung cancer types using deep learning

Abstract Deep learning for digital pathology is hindered by the extremely high spatial resolution of whole-slide images (WSIs). Most studies have employed patch-based methods, which often require detailed annotation of image patches. This typically involves laborious free-hand contouring on WSIs. To alleviate the burden of such contouring and obtain benefits from scaling up training with numerous WSIs, we develop a method for training neural networks on entire WSIs using only slide-level diagnoses. Our method leverages the unified memory mechanism to overcome the memory constraint of compute accelerators. Experiments conducted on a data set of 9662 lung cancer WSIs reveal that the proposed method achieves areas under the receiver operating characteristic curve of 0.9594 and 0.9414 for adenocarcinoma and squamous cell carcinoma classification on the testing set, respectively. Furthermore, the method demonstrates higher classification performance than multiple-instance learning as well as strong localization results for small lesions through class activation mapping.
Quantum-dot-based deterministic photon–emitter interfaces for scalable photonic quantum technology

The scale-up of quantum hardware is fundamental to realize the full potential of quantum technology. Among a plethora of hardware platforms, photonics stands out: it provides a modular approach where the main challenges lie in the construction of high-quality building blocks and in the development of methods to interface the modules. The subsequent scale-up could exploit mature integrated photonics foundry technology to produce small-footprint quantum processors of immense complexity. Solid-state quantum emitters can realize a deterministic photon-emitter interface and enable key quantum photonic resources and functionalities, including on-demand single- and multi-photon-entanglement sources, as well as photon-photon nonlinear quantum gates. In this Review, we use the example of quantum dot devices to present the physics of deterministic photon-emitter interfaces, including the main photonic building blocks required to scale up, and discuss quantitative performance benchmarks. While our focus is on quantum dot devices, the presented methods also apply to other quantum-emitter platforms such as atoms, vacancy centres, molecules and superconducting qubits. We also identify applications within quantum communication and computing, presenting a route towards photonics with a genuine quantum advantage.
A2N: Attending to Neighbors for Knowledge Graph Inference

State-of-the-art models for knowledge graph completion aim at learning a fixed embedding representation of entities in a multirelational graph which can generalize to infer unseen entity relationships at test time.This can be sub-optimal as it requires memorizing and generalizing to all possible entity relationships using these fixed representations.We thus propose a novel attentionbased method to learn query-dependent representation of entities which adaptively combines the relevant graph neighborhood of an entity leading to more accurate KG completion.The proposed method is evaluated on two benchmark datasets for knowledge graph completion, and experimental results show that the proposed model performs competitively or better than existing state-of-the-art, including recent methods for explicit multi-hop reasoning.Qualitative probing offers insight into how the model can reason about facts involving multiple hops in the knowledge graph, through the use of neighborhood attention.
Graph Neural News Recommendation with Unsupervised Preference Disentanglement

With the explosion of news information, personalized news recommendation has become very important for users to quickly find their interested contents. Most existing methods usually learn the representations of users and news from news contents for recommendation. However, they seldom consider high-order connectivity underlying the user-news interactions. Moreover, existing methods failed to disentangle a user’s latent preference factors which cause her clicks on different news. In this paper, we model the user-news interactions as a bipartite graph and propose a novel Graph Neural News Recommendation model with Unsupervised Preference Disentanglement, named GNUD. Our model can encode high-order relationships into user and news representations by information propagation along the graph. Furthermore, the learned representations are disentangled with latent preference factors by a neighborhood routing algorithm, which can enhance expressiveness and interpretability. A preference regularizer is also designed to force each disentangled subspace to independently reflect an isolated preference, improving the quality of the disentangled representations. Experimental results on real-world news datasets demonstrate that our proposed model can effectively improve the performance of news recommendation and outperform state-of-the-art news recommendation methods.
Dual Encoding for Video Retrieval by Text

This paper attacks the challenging problem of video retrieval by text. In such a retrieval paradigm, an end user searches for unlabeled videos by ad-hoc queries described exclusively in the form of a natural-language sentence, with no visual example provided. Given videos as sequences of frames and queries as sequences of words, an effective sequence-to-sequence cross-modal matching is crucial. To that end, the two modalities need to be first encoded into real-valued vectors and then projected into a common space. In this paper we achieve this by proposing a dual deep encoding network that encodes videos and queries into powerful dense representations of their own. Our novelty is two-fold. First, different from prior art that resorts to a specific single-level encoder, the proposed network performs multi-level encoding that represents the rich content of both modalities in a coarse-to-fine fashion. Second, different from a conventional common space learning algorithm which is either concept based or latent space based, we introduce hybrid space learning which combines the high performance of the latent space and the good interpretability of the concept space. Dual encoding is conceptually simple, practically effective and end-to-end trained with hybrid space learning. Extensive experiments on four challenging video datasets show the viability of the new method. Code and data are available at https://github.com/danieljf24/hybrid_space.
Demonstration of fault-tolerant universal quantum gate operations

Quantum computers can be protected from noise by encoding the logical quantum information redundantly into multiple qubits using error-correcting codes1,2. When manipulating the logical quantum states, it is imperative that errors caused by imperfect operations do not spread uncontrollably through the quantum register. This requires that all operations on the quantum register obey a fault-tolerant circuit design3-5, which, in general, increases the complexity of the implementation. Here we demonstrate a fault-tolerant universal set of gates on two logical qubits in a trapped-ion quantum computer. In particular, we make use of the recently introduced paradigm of flag fault tolerance, where the absence or presence of dangerous errors is heralded by the use of auxiliary flag qubits6-10. We perform a logical two-qubit controlled-NOT gate between two instances of the seven-qubit colour code11,12, and fault-tolerantly prepare a logical magic state8,13. We then realize a fault-tolerant logical T gate by injecting the magic state by teleportation from one logical qubit onto the other14. We observe the hallmark feature of fault tolerance-a superior performance compared with a non-fault-tolerant implementation. In combination with recently demonstrated repeated quantum error-correction cycles15,16, these results provide a route towards error-corrected universal quantum computation.
E-AUA: An Efficient Anonymous User Authentication Protocol for Mobile IoT

The emergence of the mobile Internet of Things (IoT) has made our lives smarter, relying on its various mobile IoT devices and services provided. However, with the explosively emerging mobile IoT services, malicious attackers can access them in an unauthorized way. In this paper, we designed an Efficient Anonymous User Authentication (E-AUA) protocol between the users and servers based on multiserver architectures, which contain multiple servers to address the problem of network congestion in mobile IoT. Furthermore, the E-AUA protocol was designed with a dual messages mechanism with strong anti-attack ability, lower communication and computation costs. Comparing with the state of the art protocols, our E-AUA protocol reduced both communication and computation costs. We also provided a security analysis to demonstrate that our E-AUA protocol is secure and meets a variety of security requirements in a motivated mobile IoT scenario.
Improved Fault-Tolerant Quantum Simulation of Condensed-Phase Correlated Electrons via Trotterization

Recent work has deployed linear combinations of unitaries techniques to reduce the cost of fault-tolerant quantum simulations of correlated electron models. Here, we show that one can sometimes improve upon those results with optimized implementations of Trotter-Suzuki-based product formulas. We show that low-order Trotter methods perform surprisingly well when used with phase estimation to compute relative precision quantities (e.g. energies per unit cell), as is often the goal for condensed-phase systems. In this context, simulations of the Hubbard and plane-wave electronic structure models with $N < 10^5$ fermionic modes can be performed with roughly $O(1)$ and $O(N^2)$ T complexities. We perform numerics revealing tradeoffs between the error and gate complexity of a Trotter step; e.g., we show that split-operator techniques have less Trotter error than popular alternatives. By compiling to surface code fault-tolerant gates and assuming error rates of one part per thousand, we show that one can error-correct quantum simulations of interesting, classically intractable instances with a few hundred thousand physical qubits.
Deep Learning Based Automatic Malaria Parasite Detection from Blood Smear and Its Smartphone Based Application

Malaria is a life-threatening disease that is spread by the Plasmodium parasites. It is detected by trained microscopists who analyze microscopic blood smear images. Modern deep learning techniques may be used to do this analysis automatically. The need for the trained personnel can be greatly reduced with the development of an automatic accurate and efficient model. In this article, we propose an entirely automated Convolutional Neural Network (CNN) based model for the diagnosis of malaria from the microscopic blood smear images. A variety of techniques including knowledge distillation, data augmentation, Autoencoder, feature extraction by a CNN model and classified by Support Vector Machine (SVM) or K-Nearest Neighbors (KNN) are performed under three training procedures named general training, distillation training and autoencoder training to optimize and improve the model accuracy and inference performance. Our deep learning-based model can detect malarial parasites from microscopic images with an accuracy of 99.23% while requiring just over 4600 floating point operations. For practical validation of model efficiency, we have deployed the miniaturized model in different mobile phones and a server-backed web application. Data gathered from these environments show that the model can be used to perform inference under 1 s per sample in both offline (mobile only) and online (web application) mode, thus engendering confidence that such models may be deployed for efficient practical inferential systems.
Applying Blockchain Technology to Address the Crisis of Trust During the COVID-19 Pandemic

The widespread death and disruption caused by the COVID-19 pandemic has revealed deficiencies of existing institutions regarding the protection of human health and well-being. Both a lack of accurate and timely data and pervasive misinformation are causing increasing harm and growing tension between data privacy and public health concerns.This aim of this paper is to describe how blockchain, with its distributed trust networks and cryptography-based security, can provide solutions to data-related trust problems.Blockchain is being applied in innovative ways that are relevant to the current COVID-19 crisis. We describe examples of the challenges faced by existing technologies to track medical supplies and infected patients and how blockchain technology applications may help in these situations.This exploration of existing and potential applications of blockchain technology for medical care shows how the distributed governance structure and privacy-preserving features of blockchain can be used to create "trustless" systems that can help resolve the tension between maintaining privacy and addressing public health needs in the fight against COVID-19.Blockchain relies on a distributed, robust, secure, privacy-preserving, and immutable record framework that can positively transform the nature of trust, value sharing, and transactions. A nationally coordinated effort to explore blockchain to address the deficiencies of existing systems and a partnership of academia, researchers, business, and industry are suggested to expedite the adoption of blockchain in health care.
Drivers of Acceptance of COVID-19 Proximity Tracing Apps in Switzerland: Panel Survey Analysis

Digital proximity tracing apps have been released to mitigate the transmission of SARS-CoV-2, the virus known to cause COVID-19. However, it remains unclear how the acceptance and uptake of these apps can be improved.This study aimed to investigate the coverage of the SwissCovid app and the reasons for its nonuse in Switzerland during a period of increasing incidence of COVID-19 cases.We collected data between September 28 and October 8, 2020, via a nationwide online panel survey (COVID-19 Social Monitor, N=1511). We examined sociodemographic and behavioral factors associated with app use by using multivariable logistic regression, whereas reasons for app nonuse were analyzed descriptively.Overall, 46.5% (703/1511) of the survey participants reported they used the SwissCovid app, which was an increase from 43.9% (662/1508) reported in the previous study wave conducted in July 2020. A higher monthly household income (ie, income >CHF 10,000 or >US $11,000 vs income ≤CHF 6000 or <US $6600 [reference]: odds ratio [OR] 1.92, 95% CI 1.40-2.64), more frequent internet use (ie, daily [reference] vs less than weekly: OR 0.37, 95% CI 0.16-0.85), better adherence to recommendations for wearing masks (ie, always or most of the time [reference] vs rarely or never: OR 0.28, 95% CI 0.15-0.52), and nonsmoker status (OR 1.32, 95% CI 1.01-1.71) were associated with an increased likelihood for app uptake. Citizenship status (ie, non-Swiss citizenship vs. Swiss [reference]: OR 0.61, 95% CI 0.43-0.87), and language region (French vs Swiss German [reference]: OR 0.61, 95% CI 0.46-0.80) were associated with a lower likelihood for app uptake. Further analysis in a randomly selected subsample (n=712) with more detailed information showed that higher levels of trust in government and health authorities were also associated with a higher likelihood for app uptake (ie, high vs low [reference] trust: OR 3.13, 95% CI 1.58-6.22). The most frequent reasons for app nonuse were lack of perceived benefit of using the app (297/808, 36.8%), followed by the lack of a compatible phone (184/808, 22.8%), and privacy concerns (181/808, 22.4%).Eliminating technical hurdles and communicating the benefits of digital proximity tracing apps are crucial to promote further uptake and adherence of such apps and, ultimately, enhance their effectiveness to aid pandemic mitigation strategies.
Improving Pairwise PEE via Hybrid-Dimensional Histogram Generation and Adaptive Mapping Selection

Pairwise prediction-error expansion (pairwise PEE) is a recent technique for the high-dimensional reversible data hiding. However, in the absence of adaptive embedding, its potential has not been fully exploited. In this paper, we propose the adaptive pixel pairing (APP) and the adaptive mapping selection for the enhancement of pairwise PEE. Our motivation is twofold: building a sharper 2D histogram and designing the effective 2D mapping for it. In APP, we consider to increase the similarity between pixels in a pair, by excluding the rough pixels from pairing and only putting the smooth pixels into pairs. In this way, the pixels in a pair have a larger possibility of being equal, and thus the resulted 2D prediction-error histogram (PEH) has lower entropy. Next, the adaptive mapping selection mechanism is introduced to properly determine the optimal modification, based on “whether it fits for the resulted PEH” rather than heuristic experience. The experimental results show that the proposed method has a significant improvement over the pairwise PEE.
Adversarial Examples: Opportunities and Challenges

Deep neural networks (DNNs) have shown huge superiority over humans in image recognition, speech processing, autonomous vehicles, and medical diagnosis. However, recent studies indicate that DNNs are vulnerable to adversarial examples (AEs), which are designed by attackers to fool deep learning models. Different from real examples, AEs can mislead the model to predict incorrect outputs while hardly be distinguished by human eyes, therefore threaten security-critical deep-learning applications. In recent years, the generation and defense of AEs have become a research hotspot in the field of artificial intelligence (AI) security. This article reviews the latest research progress of AEs. First, we introduce the concept, cause, characteristics, and evaluation metrics of AEs, then give a survey on the state-of-the-art AE generation methods with the discussion of advantages and disadvantages. After that, we review the existing defenses and discuss their limitations. Finally, future research opportunities and challenges on AEs are prospected.