Premise: 1 per 10,000 for this syndrome. There were no confirmed serious cutaneous diagnoses in 1,504 new valproate users. During the first few weeks of initiating therapy with phenytoin or carbamazepine, the clinician should be aware of the uncommon possibility that a cutaneous eruption could evolve into a significantly more serious reaction
Statement: During the first few weeks of initiating therapy with phenytoin or carbamazepine, the clinician should be aware of the rare possibility that a cutaneous eruption could evolve into a significantly more serious reaction
Relationship: entailment