RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Macroscopic active particles driven by light', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

In the last years, there has been an outstanding growing interest in active matter. In these complex systems, a number of interacting agents consume and convert energy into mechanical motion, representing nice examples of out-of-equilibrium behavior. Such systems are important because they can be found in nature ranging from the microscopic to the macroscopic scale, e.g. molecular motors, cells, bird flocks, or human crowds. Interestingly, and despite the obvious differences among the agents that compose these systems, common behavioral patterns have been identified such as collective motion, anomalous diffusion, segregation, or clogging in the flow through constrictions. Aiming for a better understanding of these complex active systems a reductionist strategy is necessary, and this is why the study of active granular matter (very simple self-propelled agents that interact uniquely by contacts) is widely acknowledged. Within active grains, we can distinguish between internally excited ones (such as Hexbugs) or externally forced ones. Certainly, the former have the advantage to closely resemble real active matter but, to date, also have the drawback of not allowing testing their response to external stimulus. My proposal, PhotoActive, aims to fill this gap by designing novel macroscopic self-propelled agents that are internally excited but can be driven by an external stimulus as it occurs with all natural systems. The idea is to develop and implement Hexbug-like particles whose source of energy comes from a photovoltaic cell. The great advantage of these novel agents concerns the versatility that provides using a fully controllable illumination panel with which we can impose spatial intensity gradients or temporally evolving patterns. In this way, and applying an interd
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Asymmetric nucleophilic alkenoylation with metalated chiral aminonitriles' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

TXT=AB Research objectives and content The proposed research sets out to continue the investigation into the use of reversed polarity reagents bearing chiral auxiliaries in the asymmetric synthesis of 1,2- and 1,4-difunctionlised materials as building blocks for organic synthesis. Enders has recently demonstrated that metalated aminonitriles, derived from aldehydes, and bearing a chiral auxiliary at the amino group, undergo highly diastereoselective 1,4-nucleophilic additions to (a,_)-unsaturated ketones. It is proposed to expand on this methodology by investigating the use of enantiomerically pure metalated aminonitriles derived from (a,_)-unsaturated aldehydes, in additions to both aldehydes and (a,_)-unsaturated carbonyl compounds, in order to access 1,2- and 1,4-difunctionalised materials in high enantiomeric excess. This would provide a useful method for generating chiral alkenoyl anion synthon equivalents It will be necessary to investigate the influence of steric and electronic factors on the regioselectivity of additions by these ambident nucleophiles as alkenoyl anion or homoenolate equivalents In addition, it will be necessary to determine the diastereoselectivity of the addition reactions of the alalkenoyl anion equivalents and the enantiomeric purity of their hydrolysis products - expected to be 1,2- and 1,4-difunctionalised ketones. Training content (objective, benefit and expected impact) The opportunity to carry out this research will allow the further development of skills and ideas in asymmetric synthesis and organic synthesis in general. The research team at RWTH can provide the facilities and the experience needed to achieve high standards in training. Links with industry / industrial relevance (22) Not Applicable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A Unified Approach to Redox-Neutral C-C Couplings: Exploiting Vinyl Cation Rearrangements'.

assistant: **Objectives**

The preparation of complex molecular architectures employing multi-component reactions where the number of bond-forming events is maximised is a central goal of the discipline of Organic Synthesis. The contemporary, pressing need for sustainable chemical reactions has raised the demand for novel reaction families that explore the concept of redox-neutrality and proceed with the generation of minimal waste. In this proposal, I present a unified and conceptually novel approach to atom-economical C-C bond formation in challenging contexts without the need for transition metal promoters or reagents. To this end, I propose the innovative harvesting of the potential of vinyl cation intermediates as platforms for the deployment of nucleophilic entities capable of orchestrating rearrangement reactions. The combination of such high-energy intermediates, generated under mild conditions, with the power of carefully designed rearrangements leads to an array of useful new transformations. Furthermore, the very high atom-economy and simplicity of these reactions renders them not only sustainable and environmentally friendly but also highly appealing for large-scale applications. Additional approaches to enantioselective synthesis further enhance the methods proposed. The paradigm proposed herein for the exploitation of vinyl cations will also open up new vistas in the centuries-old aldol reaction and in amination chemistry. This showcases the vast potential of these simple principles of chemical reactivity. The myriad of new reactions and new product families made possible by VINCAT will decisively enrich the toolbox of the synthetic practitioner.


**Keywords:** rearrangements, redox-neutral, C-C coupling, vinyl cations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Flexible Open Architecture and AI-driven Enabling Technologies for a Novel 6G Connectivity Platform' (FLECON-6G).

assistant: **Concept**

FLECON-6G gathers key participants from Phase-1 and Phase-2 SNS JU projects, aiming to make the “Intelligent 6G Network of Networks” vision a reality, with Trustworthiness and Generalisability of Native AI and Network Digital Twins (NDT) assisted approaches. It aims to deliver key technological assets in the form of collaborative and distributed frameworks offering scalability and support for multi-domain, multi-stakeholder infrastructures, jointly with network infrastructure programmability that supports the offloading of network application logic. FLECON-6G provides groundbreaking research to drive the next phase of 6G Native AI research, addressing Trustworthiness and Generalizability via novel intent-driven frameworks and robust Foundation Models, that not only deliver zero-touch orchestration but also performance guarantees and robustness in multi-stakeholder infrastructures. A multi-layer, multi-vendor NDT framework will also assist online decisions and resolve conflicts among multiple closed control loops operating in reactive, proactive or predictive mode for zero-touch self-optimisation. At the business layer, a Smart Marketplace will facilitate the creation of a wide, sustainable ecosystem of highly diversified stakeholders, through which, MNOs, digital service providers, verticals and software developers of AI or DT software applications will jointly collaborate to build more integrated and intent-driven service offers, composing a plethora of modular assets for their effective monetisation. In line with EU’s policies, FLECON-6G will design, develop and validate through relevant PoCs, several secure, trustworthy, resilient and reliable solutions across 4 heterogeneous verticals that require 6G performance capabilities. FLECON-6G will strongly impact standardi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Induced Resistance in tomato by beneficial microorganisms - Translating Arabidopsis-derived molecular knowledge on defense signaling' in the context of a Seventh Framework call.

assistant: **Objectives**

Similarly to pathogens, the interaction with beneficial microorganisms (such as growth–promoting rhizobacteria (PGPR) and Trichoderma) can induce in plants a form of immunity and is known as Induced Systemic Resistance (ISR), which renders plants resistant to subsequent attack by a broad spectrum of pathogens. Multidisciplinary strategies and high throughput global methodologies are contributing to understanding of the mechanisms underlying the ISR signaling network. It was demonstrated that diverse hormones play pivotal roles in the regulation of this network. From research executed with the genetic model plant Arabidopsis is has become apparent that the signalling pathways controlled by phytohormones cross-communicate, providing the plant with a powerful capacity to finely regulate its immune response. However, while the vast majority of the advances in the understanding of the plant immune signaling network has been carried out using Arabidopsis, relatively little information on plant immunity regulation in crop plants is known. This proposal aims to apply the Arabidopsis-derived molecular knowledge to the economically and ecologically important crop species tomato to: (1) elucidate the genetic control of resistance induced by beneficial soil-borne microorganisms (PGPR and Trichoderma) through a multidisciplinary approach and (2) identify similarities and differences between the immune signaling networks of these two different plant species. Using a combination of studies based on molecular biology, biochemistry, genomics and bioinformatics (analyses of gene expression by real-time PCR and microarrays, hormonal profiling, generation of transgenic plants using RNAi, among others) an integrative analysis of the mechanisms controlling ISR is proposed. The relevance of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regulation of early colorectal cancer tumorigenesis by nutrient signalling of intestinal stem cells and their tissue environment' (TEATIME) under Horizon Europe.

assistant: **Objectives**

Colorectal cancer (CRC) is the second most common cancer and nutrition influences its prevalence. CRC originates from intestinal stem cells (ISCs) and is initiated by specific genetic alterations, which influence cell growth, proliferation and fate. How nutrient signalling within the mutated ISCs and the surrounding tissue environment influences the early steps of CRC tumorigenesis and whether genetically distinct tumour types react differently to nutrition remains poorly understood. The host laboratory has recently discovered a mechanism that couples nutrient-dependent control of ISC size to cell fate regulation. As distinct tumorigenic genotypes display different fate profiles, I hypothesise that nutrient-dependent control of ISC size differentially modulates phenotypes of CRC-associated gene variants. To test this, I will utilise the Drosophila midgut model as well as the fully defined Drosophila diet to systematically uncover the nutrient vulnerabilities of several ISC-derived tumorigenic genotypes. As my preliminary data implicates the role of nutrient signalling in the tissue environment, I will develop a new dual gene expression tool, enabling simultaneous genetically control of the tumour and the neighbouring tissue. I will combine transcriptomics, metabolomics and organ-wide imaging with quantitative image analysis to mechanistically address how changes in nutrient signalling and metabolism of oncogenic and surrounding wild-type cells influence tumour initiation. To test the conservation of the main findings in Drosophila, I will utilise the CRC models of mouse intestinal organoids.  Collectively, this project will address how nutrient regulation of ISCs and their tissue environment will affect the initial events of CRC tumorigenesis.


**Keywords:** stem cell,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dioxygen activation by copper in an inert cage' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The aim of the project is to design and synthesize a new type of low-molecular-weight single Cu site which smoothly converts organic substrates to oxidised/oxygenated products in the presence of benign oxidants O2 or H2O2. In particular, the copper site is located at the bottom of a chemically inert cage, which should enhance the lifetime of a Cu(I)-O2 adduct at room temperature and prevent intra-molecular oxygenation of the ligand, but at the same time favours reaction with substrates by their incorporation in the cavity and exposure to the activated O2 species.These systems are believed to be ideal models for a study of the properties and reactivity of monocopper-oxygen species, and potentially new reagents or catalyst for selective oxidations/oxygenations including less reactive hydrocarbon substrates (arenes, alkenes, alkanes). Since the covalent synthesis of such an encaged copper centre would be rather challenging, the metal-based assembly of the cage from a tripodal precursor and an allosteric, second metal ion is suggested, to obtain the target ligand readily and in sufficient quantity for thorough investigations including screening of reactivity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Search for Higgs boson decays into Light Bosons in Boosted Hadronic final states' (LightBosons).

assistant: **Concept**

The observation and characterisation of the Higgs boson represents the culmination of over forty years of experimental and theoretical progress, cementing the Standard Model (SM) as the most successful fundamental physical theory to date. However, many open questions still remain which can only be addressed with the new physics predicted by many beyond the SM (BSM) theories. Many such theories, such as two Higgs doublet models and the next Next-to-Minimal Supersymmetric Standard Model, also predict new light bosons or an extended Higgs sector. The observation of the Higgs boson opens a new window to search for such new particles, denoted a. This project aims to observe the production of new light hadronically decaying bosons in the Higgs boson decays h->Za, focusing on h->Za->ll+hadrons final states. This is breaking new ground as the h-> Za channel is entirely uncharted territory, only recently proposed, which will probe large parts of the currently allowed 2HDM parameter space. These searches have been out-of-reach to-date due to the challenge of reconstructing low-mass boosted hadronic objects. The exploitation of these channels will require significant innovations such as the development of new reconstruction techniques for boosted low mass hadronic resonances. Looking to the future the upgrade of the ATLAS Inner Tracker is of paramount importance to fully exploit the physics potential of this project with the High Luminosity LHC. The results of this project will represent an important step towards understanding the extent of the Higgs sector or lead to a revolutionary discovery, the first observation of BSM physics at the LHC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fiber grating stabilized laser sources for application in wdm communication networks' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The development of WDM communication networks with increasing capacity puts high requirements on wavelength selective elements such as light sources, multiplexer and cross-connects. Advanced light sources play a vital role for performance and reliability of optical networks.. The proposed project contains detailed experimental and theoretical studies that focus on the important aspect of the spectral stability of laser sources. 1. Analysis and optimization of spectral characteristics of semiconductor lasers 2. Fundamental limits of laser sources within optical networks architectures 3. Design and characterization of fiber lasers and their comparison with semiconductor lasers Unlike many strategies in laser development, the proposed project directly takes into account all important aspects of implementing the laser sources into optical networks. A research program in this field is expected to give detailed recommendation for optimized laser sources that are indispensable for future improvement in network performance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Extended Collaborative integrated Life cycle supply chain Planning System' (ECLIPS), addressing dissemination and exploitation.

assistant: **Impact**

As a consortium we want to address two key challenges to the European industry. A first is to globalise their supply chains while reducing inventory investments. Globalisation is an opportunity for both selling and sourcing but it increases lead times and their variability. As such it increases inventories and working capital. To meet competition in a global economy it is necessary to reduce working capital needs.A second key challenge to the European industry is to deliver ever-more customized and up-to-date products, again while reducing inventory investments. Today, product introduction and end-of-life stages are typically poorly supported and managed, resulting in excess inventories. To meet the demand of a global but more individualized customer it is important to increase the pace of product introductions while decreasing working capital needs.As a consortium spanning the academic, the business and the world of information technology, we see an opportunity in leveraging recent advancements in information technology to feed breakthrough multi-echelon supply chain optimisation models. Our key value proposal is to improve and automate product life cycle management over multiple levels in a supply chain. We believe the different stages of a product life cycle need a different answer. We propose breakthrough innovation for the different stages (introduction/maturity/end-of-life). In a next step we address the integration of these stages. Automated switching from one technique to another is important in sustaining shortening product life cycles.This automated switching is a green field from both an academic and a business perspective. Our consortium will develop optimisation components and package them into an add-on that can easily be integrated with existing ERP and A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Econometrics for Macroeconomic Policy Evaluation' (POLICYMETRICS), addressing dissemination and exploitation.

assistant: **Impact**

Traditionally, the evaluation of macroeconomic policy has relied on analyzing specific economic models which often do not correspond to the complex and data-rich environments in which real world policy decisions are made. To this extent, I propose to develop a new framework for evaluating macroeconomic policy decisions ---policymetrics--- that is inspired by the robust inference literature in econometrics and makes minimal assumptions on the underlying economic model. The methodology detects optimization failures, i.e. instances in which policy decisions do not minimize the (welfare) loss function, and determines the causes and dynamics of such failures, all while fully respecting the limitations imposed by the Lucas critique. Part 1. The detection of optimization failures is based on the gradient of the loss function evaluated at the proposed policy choice. The key insight is that for large classes of macroeconomic loss functions the gradient only depends on known or estimable sufficient statistics such as forecasts, dynamic causal effects and preferences. I will  tailor the methodology to allow for constrained policy problems, risk aversion and the real-time detection of optimization failures.     Part 2. The methodology for understanding optimization failures is inspired by the forecast evaluation literature and aims to infer which trade-offs, across mandates and horizons, dynamics and variables were overlooked when setting policy. Among others, I will develop methods that test for systematic optimization failures, optimization encompassing and breaks in policy performance.I will apply the framework to evaluate contemporaneous and historical monetary, fiscal and climate policy decisions from different governments and institutions around the world, hereby providing a