RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Beyond EPICA Oldest Ice Core: 1,5 Myr of greenhouse gas – climate feedbacks' in the context of a Horizon 2020 call.

assistant: **Objectives**

To better constrain the long-term response of Earth's climate system to continuing greenhouse gas emissions, it is essential to turn to the past. A key advance would be to understand the shift in Earth's climate response to orbital forcing during the 'Mid-Pleistocene transition' [MPT, 900,000 (900 kyr) to 1.2 million years (1.2 Myr) ago], when a dominant 40 kyr cyclicity gave way to the current 100 kyr period. It is critical to understand the role of forcing factors and especially of greenhouse gases in this transition. Unravelling such key linkages between the carbon cycle, ice sheets, atmosphere and ocean behaviour is vital, assisting society to design an effective mitigation and adaptation strategy for climate change. Only ice cores contain direct and quantitative information about past climate forcing and atmospheric responses. However, the longest (EPICA) ice core record available to date covers only the last 800 kyr. The RIA Topic LC-CLA-08-2018 empowers the European ice core community to perform such an oldest ice core drilling and the project 'Beyond EPICA' is taking on this unique challenge and opportunity. The overarching scientific objective driving 'Beyond EPICA' is to obtain quantitative, high-resolution ice- core information on climate and environmental changes over the last 1.5 Myr. The cause and effect relationship that led to the enigmatic MPT change in the climate system is not understood yet, as important information on global changes in the climate system is still missing. Most of this information, including the phasing of these changes in the Earth System can only be derived from a continuous ice core from Antarctica covering the last 1.5 Myr. This proposal uses the planning derived during the recent BE-OI CSA, and offers an excellent team (the only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Finishing the yeast genome sequencing'.

assistant: **Concept**

On the eve of 1996, a total of 12,250,000 bp of final DNA sequence of the yeast genome has been deposited in EMBL, GENBANK or MIPS data bases. This corresponds to 98% of the nuclear yeast genome excluding the two major repeated regions amounting to more than a million of base pairs. About 76% of the world wide submitted yeast sequences were carried out in Europe; 59% being funded by the EU and 17% being funded by the WELLCOME TRUST FOUNDATION (SANGER CENTER). It is Europe's duty and interest to take care that the yeast genome sequence be not only the first eucaryotic one to be fully completed but also be a model for quality and usefulness to science and industry. We therefore propose three subprojects; the feasibilities of which have been tested carefully. The first subproject aims to the sequencing of mitochondrial DNA and of the two repeated regions not checked so far. The second subproject aims to the assessment of the true error rate and to the correction of 30 to 50 % of the estimated 2500 to 3750 remaining sequencing errors (one error per two or three genes). The third subproject aims at the maintenance of the corrected genome sequence data base. The sequencing laboratories involved have proved to be among the most efficient and the most reliable ones involved in the yeast genome sequencing. The technical approaches proposed have original components and are extremely cost efficient: 0.1, 0.3 or 1.0 ecu/bp according to the topic. The verification procedures will be exploited at little extra cost for obtention of useful informations on strains of industrial interests. All subprojects might be considered as pilot projects for similar approaches on other genomes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Diagnosing platform for neurological and mental disorders based on the analysis of ocular and oculocephalic movements.' under Horizon 2020.

assistant: **Concept**

The first product that AURA will launch to the market will be OSCANN, a diagnosis platform that will allow better, fasterand more accurate diagnosis of neurological disorders affecting Europe’s population in general, but specially youngsters(e.g. ADHD) and elders (e.g. Parkinson). OSCANN allows for the measurement and analysis of ocular and oculocephalicmovements (OM/OCM) and combines the result with data obtained from other sources (clinical histories, medicalexplorations, complementary tests and biomarkers) using Artificial Intelligence (AI) techniques to improve significantly thequality of medical diagnosis in early stages.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Signature of sediment CAscades following Landslides triggered by Extreme Events in the Stratigraphy'.

assistant: **Innovation**

Catastrophic sediment release in fluvial systems is largely driven by landsliding that occurs naturally during extreme events such as earthquakes or storms in mountain belts. Sediments cascade through the river system until they are stored either permanently in alluvial fans and lakes or temporarily in terraces. To mitigate future landslide hazards, it is urgent to better understand past extreme events such as their amplitude and frequencies, which calls for an improved identification of a landslide signal in the stratigraphy. The SCALEES (Signature of sediment CAscades following Landslides triggered by Extreme Events in the Stratigraphy) project aims to provide a calibrated and validated numerical model of multi-grain size sediment transport and storage that will be apply to unravel the signal of landslides preserved in lakes or alluvial fans and in terraces. To do so, this numerical model that is a recent development of the established RIVER.lab landscape evolution model will be parametrised using extensive and unique data collected in New Zealand where co-seismic landslides have heavily impacted landscapes. The combination of empirical data with numerical simulations will allow us to predict for the first time the full signal (all grain sizes) of sediment cascades preserved in the stratigraphy in response to an extreme event at the scale of a catchment. The project builds up upon the complementary expertise of the fellow in the field of numerical modelling of sediment transport and storage, of the outgoing supervisor in sedimentology related to natural hazards and of the return supervisor in fluvial geomorphology. Through the access to a unique dataset of post-earthquake records as well as scientific networks and the design of a detailed career development plan and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bridging the Gap: Discovering real-life Scientists across Portugal 2009' (SCIENTISTSACROSSPT09), addressing dissemination and exploitation.

assistant: **Impact**

The Portuguese research landscape has undergone a profound transformation in the last 15 years. Several initiatives have already taken place in Portugal in order to close the still existing gap between science and society, promote the development of positive attitudes towards science and technology and to have the public at large to better understand the central role of scientists and the key benefits that they bring to society. Nevertheless, significant efforts remain to be undertaken in Portugal for breaking the existing stereotypes about the researchers and the profession and to enhance researchers' public recognition.The purpose of the “ScientistsAcrossPortugal_09” is to continue to tackle the existing stereotypes of researchers and to have the public at large, and especially youngsters, better understand the central role of scientists and the benefits they bring to society. To accomplish this purpose, high impact events will take place in 6 cities: Aveiro, Coimbra, Covilhã, Lisbon, Tomar and Vila Real. At least 6,000 participants are expected, more than 100,000 people from numerous sectors are estimated to be aware of the event and at least 250 researchers, are expected to be directly involved in the delivery of the events.Considering the diversity of the public expected to participate in the “Scientists Across Portugal 2009” events, were defined specific target groups that the project will address: Children and youths; Students; Parents; Senior citizens; Educators/teachers/trainers; Companies and business leaders; Regional authorities; Business, youth and students associations; Decision makers and media professionals. For each one of the above groups will be defined and implemented a set of differentiated activities, adapted to the targets’ characteristics and nee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A complete solution for Si-based All-Solid-State Batteries by ensuring a long-term conductive environment and mitigating the strain mismatch between the electrode and the solid-state electrolyte' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

With higher energy density and better safety, all-solid-state batteries (ASSBs) are considered as an important direction for the next generation of lithium batteries, as well as part of the EU's battery program. The replacement of liquid electrolytes with solid electrolytes (SEs) has led to an unprecedented level of research on Li metal anodes. However, uneven deposition of Li-ions leads to lithium dendrites and interfacial gaps, which is an unavoidable electrochemical behavior and unavoidable. Silicon (Si) materials are underappreciated due to the large volume change during cycling. Nevertheless, Li-ions inserting and extracting within the Si-based electrode causes volume changes and a local separation from the SE, which is a mechanical behavior and prospectively avoidable.     This proposal aims to provide a comprehensive solution for Si-based ASSBs that achieve stable long-cycle performance without excessive external stack pressure. Achieving this goal involves not only investigating SEs but also tackling issues such as low expansion Si-based materials, strain mismatch between the anode and SE, and managing complex interfaces. Specifically, the flexible conductive network in the anode electrode will provide some cushioning against volume changes of Si-based materials, and provide a long-lasting conductive environment for the electrode, which is an important guarantee for the long-term cycle of the battery. At the same time, a complex electrolyte with a certain degree of elasticity will mitigate the strain mismatch of thin-film bonding between the Si-based anodes electrode film and the SE film. The results of SIASSB provide a foundation for advancing the commercial viability of ASSBs.   SIASSB will be expected not only to advance the scientific understanding of ASSBs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Development of new therapies for brain tumours using encapsulated cell technology', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The main goal of this proposal is to develop, produce and validate a cell-based targeted therapeutic delivery system comprising cells encapsulated in an ultra pure alginate gel. Cell lines will be developed which produce tumour growth inhibitory substances such as antiangiogenic proteins (endostatin, angiostatin) as well as antibodies to cancer cell growth receptors. The encapsulated cell prototype will be evaluated for efficacy against brain tumours, for which there is no adequate treatment today. An ultra pure alginate will be developed and characterised which will meet regulatory standards for implantation into the brain. The final step in the proposal is to document the preclinical efficacy of this alginate encapsulated cell therapy towards brain tumours in small animal models such as rats and in spontaneously occurring brain tumours in dogs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative coatings on light alloys' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Preliminary System Specification (sub-task 1.1 - completed);Process Monitoring System Specification and Trials (sub-task 1.2 - completed);Special Focusing Optics Specification for HPDL (sub-task 1.3 - completed);Special Focusing Optics Design (sub-task 1.3 - completed);Adaptation of Powder delivery devices (sub-task 1.4 - completed);Processing Head Specification and preliminary design (sub-task 1.4 - completed);Realisation of coaxial nozzle for Nd: YAG laser (sub-task 1.4 - completed);Process Modelling methodologies specification (sub-task 2.1 - completed);Development of analytical and FE models (sub-task 2.1 - completed);Energy Coupling Analysis and Tests (sub-task 2.3 - completed);HPDL Specification (sub-task 3.1 - completed);Definition and Specification for HPDL modules (sub-task 3.2 - completed);Realisation of Diode bars (sub-task 3.2 - completed);Realisation of Fiber Coupling (sub-task 3.3 - completed);Source and Fibre coupled HPDL modules design (sub-task 3.3 - completed);Definition for metallurgical & tribological testing procedures (sub-task 4.3 - completed);Data analysis for monitoring system assessment (sub-task 1.2 - completed);Manufacturing of mid-range power laser diode (sub-task 3.4 - completed);FE modelling procedures for product simulation (sub-task 2.2 - completed);Parameters studies / characterisation of specific equipment (sub-task 4.1 - completed);Development of innovative additional materials (sub-task 4.2 - completed);Tribological and mechanical testing of specimens (sub-task 4.4 - completed);Preliminary System integration (Task 5 - completed);Assessment of design rules (sub-task 6.1 - completed);Assessment of manufacturing procedure (sub-task 6.2 - completed);Testing and analysis of real coated parts (sub- task 6.3 - completed).Objectives and cont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Framework architecture to semantically integrate advanced threat detection and security protection at ultra-high speeds'.

assistant: **Objectives**

This proposal addresses directly several of the major security implementation issues facing large enterprises and service providers. Specifically it seeks to create an agent-oriented layered architecture to enable the delivery of multiple pattern-based and behaviour-based scanning and filtering functions at very high speeds. The major technical objectives are to provide a framework for the concurrent operation of reactive and proactive security algorithms, to deliver algorithmic enhancements for pattern recognition and behaviour-based detection schemes, as well as enhanced and highly correlated rule sets for more efficient alarm management and root-cause analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Proteomics of neuroinflammatory signaling: Illuminating cellular mechanisms driving neurodegenerative diseases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Alzheimer’s (AD) and Parkinson’s disease (PD) are prevalent neurodegenerative diseases, but their underlying mechanisms remain poorly understood. Emerging evidence suggests that neuroinflammation, characterized by the release of pro-inflammatory cytokines like IL-1β, TNF-α, and INF-γ, plays a pivotal role in these diseases, challenging the conventional focus on protein aggregates (Aβ, αSyn). In AD, it has been shown that elevated IL-1β levels induce the translocation of NEDD8 from the nucleus to the cytoplasm, where it co-localizes with the E3-ligase Parkin. Together with the kinase PINK1, Parkin is crucial for the removal of defective mitochondria, with loss-of-function mutations in these genes being the primary cause of early-onset PD. Intriguingly, phosphorylated NEDD8 can activate Parkin, implicating a more complex interconnection between neuroinflammation, NEDD8-and Parkin-regulated phosphorylation-dependent signaling in brain cells. Yet, a mechanistic understanding of cellular processes triggered by neuroinflammation remain elusive.This proposal aims to investigate spatiotemporal (phospho-)proteome changes in response to neuroinflammatory stress elicited by pro-inflammatory cytokines and αSyn fibrils. To achieve this, I will combine spatial-proteomics using subcellular fractionation and hybrid-DIA in combination with the cutting-edge Orbitrap Astral mass spectrometer. Initial analyses of neuronal cell line models will be extended in a second step to hPSC derived neurons, astrocytes, microglia, and co-cultures thereof. This enhances the translational relevance by mimicking neuroinflammation in the complex tissue architecture of the brain. Finally, bioinformatically shortlisted neuroinflammation-regulated proteins and phospho-sites will be validated in cell-based mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hybrid Human-AI Regulation:  Supporting Young Learners' Self-Regulated Learning' (HHAIR).

assistant: **Innovation**

Hybrid systems combining artificial and human intelligence hold great promise for training human skills. I propose to develop Hybrid Human-AI Regulation (HHAIR) to develop learners’ Self-Regulated Learning (SRL) skills within Adaptive Learning Technologies (ALTs). HHAIR targets young learners (10-14 years) for whom SRL skills are critical in today’s society. Many of these learners use ALTs to learn mathematics and languages every day in school. ALTs optimize learning based on learners’ performance data but even the most sophisticated ALTs fail to support SRL. In fact, most ALTs take over (offload) control and monitoring from learners.  HHAIR on the other hand aims to gradually transfer regulation of learning from AI-regulation to self-regulation. Learners will increasingly regulate their own learning progressing through different degrees of hybrid regulation. In this way HHAIR supports optimized learning and transfer (deep learning) and development of SRL skills for lifelong learning (future learning). This project is ground-breaking in developing the first hybrid systems to train human SRL skills with AI.The design of HHAIR resolves four scientific challenges: i) identify individual learner’s SRL during learning; ii) design degrees of hybrid regulation; iii) confirm effects of HHAIR on deep learning; and iv) validate effects of HHAIR on SRL skills for future learning. The four design challenges are addressed by investigating ALTs’ trace data in exploratory studies (WP1), applying these insights to develop HHAIR in design studies (WP2), investigating immediate effects on deep learning in short-term field studies (WP3) and effects on SRL-skills for future learning in long-term field studies (WP4). The AI@EDU infrastructure will connect HHAIR to ALTs used daily in schools
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hardware realisation of communication coding algorithms' to be submitted under Fourth Framework.

assistant: **Abstract**

- Introduction of an evolutionary system development cycle based on concurrent engineering principles, replacing the existing traditional electronics design chain.- Minimising development time through the use of the new design methodology will reduce product cost and improve quality.- Demonstration of the improvement in the design practice through the design of a high complexity ASIC.- Targeted dissemination of activities to the Greek Electronics Industry.An innovative design and development environment is to be introduced using advanced EDA software tools. The new design process solution will be used for the development of an electronic system for use in data communication for the purpose of data security and integrity. The heart of the system will be an ASIC designed to realise a coding algorithm. Benefits of using advanced ESD tools will be disseminated to specific industrial sectors.