RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Artificial Metalloenzymes: Equlibrium, structural and kinetic study of low molecular weight metal complexes with diverse catalytic effects' under Sixth Framework.

assistant: **Concept**

The aim of the present project is the systematic development of peptide-based low molecular mass functional model complexes of metalloenzymes, possessing either hydrolytic or redox activity.Such compounds, being smaller, more robust and better available than the enzymes themselves, are useful to accelerate chemical reactions under mild conditions and are of great interest for biotechnological, medicinal and industrial applications, both from economical and environmental point of view.Within the scope of both sub-projects (functional model complexes of hydrolytic and redox enzymes) the synthesis of two types of ligands is envisaged:- histidine-rich linear peptides, or- tripode-like branched peptides assembling three histidine residues.These structures are expected to imitate protein folding, which would allow multiimidazole binding in the physiological pH-range (i.e. the retardation of amide co-ordination). In case of promising candidates, the synthesis of PNA-peptide hybrids will be undertaken to induce strong and site selective DNA/RNA binding.After completing the equilibrium and solution structural (UV-VIS, CD, EPR, NMR) studies of the Cu(II)- and Zn(II)-ligand systems, sufficient information are in hand to plan the optimal conditions (pH, concentrations, metal-to-ligand ratios, etc.) for the kinetic measurements, targeting both the hydrolysis of DNA/RNA models (Cu(II) and Zn(II) complexes) and the oxidation of various aromatic compounds (Cu(II) complexes). The present proposal aims to reintegrate a talented young scientist in his country of origin.The financial aid of the Marie Curie European Reintegration Grant, especially the purchase of an HPLC instrument, will fundamentally facilitate the build up of the candidate's own small group comprising o f postgraduate stu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Spoils of War: The Economic Consequences of the Great War in Central Europe' (SpoilsofWAR) under Horizon 2020.

assistant: **Objectives**

2018 will be a momentous year in Central Europe. It will mark the centenary of the end of World War I and the collapse of the Habsburg Empire. Political disintegration has long been blamed for the economic troubles of the successor states, but these consequences have not been subjected to sufficient examination, nor were they distinguished from the economic consequences of the Great War. My ambition is to fill this knowledge gap. I will measure systematically how the war changed (i) industrial structure, (ii) business performance, and (iii) living standards in the regions of the Habsburg Empire. I will explain, using both quantitative and qualitative methods, the mechanisms that drove these changes. I will compare real wages, the spatial distribution of industry, and the performance of industrial corporations between the prewar and postwar periods. I will directly account for the impact of the war on industrial development, independent from the outcomes of postwar disintegration, using abundant, yet understudied, primary data on war spending in the Habsburg Empire. I will detect how the reallocation of resources during the war affected changes in economic conditions (i-iii) and their regional variation. In addition, my project will prepare case studies on key industries to demonstrate how they perceived these changes and what strategies they developed to address them. SpoilsofWAR will set a new standard in the economic history of the world wars. It will generate vast volumes of new statistical evidence at the regional and micro level. Methodologically, it will break through traditional boundaries between economic and business history and integrate the analytical tools of both disciplines. It will shift focus in the recent economic history of the wars from the Second to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Dramatic hardware and energy savings in computer servers by  doubling memory capacity and bandwidth using novel general-purpose compression'.

assistant: **Concept**

Technology and computer applications require the use of massive and growing amounts of data. Random Access Memory (RAM) has a direct impact on how many programs can be executed at the same time and how much data is readily available. Advanced applications may be limited by memory bottlenecks. More (effective) memory capacity is needed, more cheaply. Data centres now consume 3% of the global electricity supply and account for 2% of total greenhouse gas emissions. This consumption is expected to triple in the next decade and may even reach 20% of the world’s energy in 2025. This is unsustainable.MaxiMem is the solution. It is a patented compression technology that is capable of storing and transporting information in computer memory as densely as possible, doubling memory capacity, bandwidth, speed and performance and potentially halving current energy expenditure.It is an IP block that can be installed on the System on Chips (SoCs) of servers, smartphones, tablets, computers and high-performance computers. Servers are our main (though not only) targets at market launch due to the sector growth and high cost saving potential. Server manufacturers could save up to 50% of memory costs and 25% of total hardware costs.Chip innovations like ours are normally evaluated through installation of hardware or a layout design on a chip, which is costly and slow. ZeroPoint will use its experience to develop business-enabling tools to realistically simulate a chip implementation of our IP within the customer’s architecture. These tools will be crucial to bring our IP technology to market.ZeroPoint was created in 2016 as a spinout from Chalmers University of Technology. We are now participating in the important EuroEXA project. SME Instrument support will greatly reduce our time-to-mark
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Transnational Community Mobilizations for Peace: French Jewish Mobilizations in Israel' to be submitted under Seventh Framework.

assistant: **Abstract**

Abstract: What motivates transnational community social movements to get involved in a violent community/ethnic conflict by choosing to practice non violent direct action (NVDA)? How do they manage to attain their objectives? What impact have these actions on the future of the movements that bring them about, the community to which they belong, and on the situation of the conflict? The purpose of this research project is to answer these questions by examining the case of transnational French Jewish peace movements that situate their non violent direct action in Israel. In the vast literature focusing on the international or transnational dimensions of community conflicts, little attention has been given so far to the role played by transnational peace movements. It seems that we still lack a comprehensive analysis of the involvement of transnational peace movement in community conflicts, especially in two directions: how are they affected by larger processes such as globalisation while contributing to shaping them? What are the local effects of their actions, both in areas affected by the conflict and in the country where they mobilize? This is especially true of peace movements which conjugate their political involvement for peace with a community orientation and membership, namely which appear to be connected to one “side” of the conflict. Not only does their action impact on the conflict, especially by acting directly in the territories where it takes place, these community peace movements also strive to change representations regarding it in the mobilizing country. This in turn modifies the content associated with a community mobilisation and affects belonging processes themselves, as the French case shows. A strong pro-peace sensibility can be observed in the Jewis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modelling and predicting sensitivity to targeted therapies in colorectal cancers' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Effective and long term treatment of cancer is now in sight, but will ultimately require an increasingly ‘personalised’ approach where the ‘right’ combination of drugs will be administered to the ‘right’ patients, based on a detailed understanding of their genetic background and their co-associated sensitivity or resistance ‘biomarkers’. Efforts are specifically required to identify validated risk and patient-response stratification criteria, which can then be used to rationally develop companion diagnostic assays and more stream-lined clinical trials.  COLTHERES will address these key issues by:1) Molecularly profiling colon cancer patient samples using multiple ‘omics based technologies for co-segregating lesions that could impart resistance to existing and emerging targeted therapies2) The building and screening of predictive in vitro models based on this data, to enable the rapid and empirical determination of drug resistance biomarkers3) The use of these models and of the clinical studies to prospectively screen for genes mediating resistance and sensitivity to targeted therapies in CRCs4) The building of new algorithms to significantly accelerate the design of rational therapies, by integrating more predictive models, assays and biomarkers into all phases of drug discovery; including novel phase-0 (xenopatients) studies5) The design of innovative and focused biomarker driven phase II trials based on knowledge gathered within the projectCOLTHERES has assembled a unique consortium, from both academia and industrial SMEs, of world- experts in the areas of;•clinical design of innovative biomarker trials and improved therapeutic strategies• ‘omics technologies including genomic, transcriptomic, epigenomic and proteomic profiling•Functional genomic and disease model-gen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Understanding the essential function of the conserved plant-specific protein phosphatase family BSL' (BSLchlamy), addressing dissemination and exploitation.

assistant: **Impact**

The protein phosphatase family BSL is highly conserved and universally present in all green plants, from single-celled algae to multicellular land plants. Genetic evidence shows that it plays an essential, albeit completely unknown, role in plant cell biology. The model plant Arabidopsis has four BSL genes, but genetic redundancy coupled with embryonic lethality of mutants has seriously hampered functional studies of the family. In contrast, the green alga Chlamydomonas reinhardtii has only a single BSL homolog and the recent isolation of a temperature-conditional mutation (bsl1-1) in this gene generated a unique tool for rapid switching of BSL activity to study its molecular/celular functions. Detailed analysis of the bsl1-1 mutant identified a role for BSl1 in cell division in Chlamydomonas, specifically in mitotic progression. This phenotype is also consistent with the reduced meristem size observed in BSL knock-down in Arabidopsis and suggests an evolutionarily conserved role for the BSL phosphatase in cell cycle regulation. In the proposed project I will first perform a comprehensive proteomic/biochemical analysis of BSL1 in Chlamydomonas to identify the mechanistic basis for its key role in mitosis. This analysis with include (i) a phosphoproteomic screen to look for substrates and downstream effectors of the BSL1 phosphatase, and (ii) a characterization the BSL1 interactome using a variety of immunoprecipitation-based methods. I will then, during the return phase, translate the findings from Chlamydomonas into Arabidopsis by studying the role of BSL during root meristem development using a combination of microscopic and genetic approaches. Given the conservation of the BSL family throughout the viridiplantae, the results from this study are likely to have a broad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'C- and N-terminal Epitope Conjugate immune Cell Targeted Vaccines' (CNECT-VAX).

assistant: **Concept**

CNECT-VAX will validate the technical and commercial feasibility of a new cancer vaccine platform that uses nanobodies targeting dendritic cells to co-deliver antigens in vivo. As of 2019, cancer affects over 19 million people worldwide and results in almost 10 million death annually, however, the treatment of patients remains a challenge. Immunotherapy options including dendritic cell (DC) based vaccines have become available, but the clinical efficacy of such treatment remains very modest and restricted to patient subsets. To overcome the limitations in the current state-of-art solutions and break barriers to achieve higher clinical efficacy, Dr. Martijn Verdoes proposes a novel molecular vaccine strategy that effectively delivers target antigens to DCs in vivo in the patient to concomitantly induce robust synergistic CD4+ and CD8+ T cell responses. The technical feasibility of CNECT-VAX will be assessed both in vitro and in vivo, using monocyte-derived human dendritic cells (MoDC) and a mouse model containing humanized DCs respectively. In both systems, the functionality of DCs and the consequent T cell activation and immune responses will be measured. Subsequently, commercial feasibility will be determined by verifying IP position and strategy, performing in-depth market and competitor analyses, and finally consolidating these into a business plan to establish the best path to commercialization. Successful commercialization of CNECT-VAX could reduce the profound socioeconomic burden of cancer, extend and improve the lives of patients, provide the pharmaceutical industry with further collaborative opportunities, and stimulate further scientific research based on this platform to treat other pathogenic diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Numerical Computation with Functions Instead of Numbers', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Numerical analysis, scientific computing, and computational science are built on technologies of discretization such as splines, finite differences, and finite elements.  Yet for most applications it is ultimately continuous functions that are of scientific interest, and the discretizations are a means to the end of working with them.  This project will advance mathematics and algorithms to enable scientists and engineers to compute with functions rather than their discretizations.  Such computations will be numerical as opposed to symbolic, for speed and wide applicability, yet will achieve some of the “feel” of symbolic computing.  The goal is to do for computing with functions what floating-point arithmetic has done for computing with numbers: to hide away details of discretization from most users, most of the time.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CIPHRA' (CIPHRA).

assistant: **Innovation**

The story of data breaches across industries with national, regional, and often global impact is a never-ending one. Theexposure of huge amounts of personal information and identities continues to be a major problem without a solution in sight(see sample on the left of recent breaches to tech giants). At the nexus of the world of cyber security and cyber-crime is theparamount issue of password and encryption key storage – the security measures in place to prevent hacking, and thecapabilities of the illegal hackers to hack into storage sites and decipher encrypted messages.Authentico has inventedCIPHRA which is a hardware dependent cryptographic processor that ensures that passwords and encryption keys areessentially impossible to steal even if a database is hacked into. CIPHRA protects the cryptographic infrastructure bysecurely processing passwords, and generating unclonable encryption keys from authentication requests using a technologycalled PUF (physically unclonable functions). Authentico´s solution stands to be a major alternative to traditional key storagemethods. The keys are always present in the device, by generating the key on request. Information, such as passwordhashes, can be inputted, but never read out or extracted. Even weak passwords cannot be broken because the generatedoutputs are useless for an attacker and the database of encrypted and hashed passwords is useless without the key. This isa far better solution than current approaches because the company’s secret keys are never stored anywhere, at any time,making it extremely difficult for any malicious insider or outside hacker to ever gain access to them.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Large scale wind tunnel turboprop aircraft model integrating morphing devices for aerodynamic experimental assessment' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

WTM-RECYCLE addresses the call JTI-CS2-2016-CFP04-REG-01-05 and will in total re-design an existing WT-model (designed and manufacturing in the JTI-CS-project LOSITA), manufacture the new parts and implement them in into the model and finally perform a WT-tests focused on delivering aerodynamic data. The results will be post-processed and implemented into an aerodynamic database supported by CFD.The model updates to be performed focus on changes that can be roughly summarized in two groups:a.)    At first model updates reflecting a new design state are implemented (e.g. fuselage geometry, fuselage length).b.)    Solutions developed within the REG-ITD which shall be tested and assessed in the WT. This specifically involves the morphing LE, TE and winglet, which shall be used as High-Lift devices.The project addressing this task is organized straight-forward using a consortium of three partners that have proven their competence in WT-model design, aerodynamic analysis and assessment as well as manufacturing in recent R&D projects. WT-test activities are subcontracted to the RUAG-WT, which is the obvious choice for test including this model. In total the project strongly benefits from the experience with the initial model of two of the partners (IBK and EUROTECH) obtained in the LOSITA-project, since they will also support the WTM-RECYCLE project.Finally an aerodynamic assessment and an extrapolation towards full-scale will be performed under the responsibility of KTH in order to display the benefits of the new High-Lift-devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'To the root of organ growth: the control of root meristem activity in Arabidopsis' to be submitted under Seventh Framework.

assistant: **Abstract**

In animals, the formation and growth of new organs cease at the completion of development; in plants, the body is continuously built throughout the plant lifespan. In addition, in plants there is virtually no cell migration due to rigid cell walls: this provides a unique opportunity for dissecting the relations between pattern formation and final organ structure.Plant post-embryonic development takes place in localized regions called meristems. In the root of Arabidopsis thaliana, stem cells in the apical region of the meristem self-renew and produce daughter cells that differentiate in the distal meristem transition zone. To ensure root growth, the rate of cell differentiation must equal the rate of generation of new cells. Recent work of the proponent has shown that maintenance of the Arabidopsis root meristem size - and consequently root growth - is controlled by the interaction between two hormones in the meristem transition zone: cytokinin, which promotes cell differentiation, and auxin, which promotes cell division, and has unveiled the regulatory circuit underlying this interaction.Scope of this proposal is to clarify how the cytokinin/auxin interaction influences the activities of the entire root meristem, thus ensuring a balance between cell differentiation and cell division.In particular, the work proposed aims to:- Clarify how the cytokinin/auxin interaction is perceived in the transition zone to bring about synchronous differentiation of all cell files of the distal meristem.- Understand how the cytokinin/auxin interaction maintains a balance between cell differentiation in the (distal) transition zone and cell division in the (apical) stem cell niche.- Unveil other inputs and regulatory circuits that interact with the cytokinin/auxin regulatory circuit in c