RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification of cellular identities and characterization of the STAT3 signalling pathway in Purkinje cell layer regeneration' (PURKINJEREG).

assistant: **Concept**

There are many degenerative diseases affecting the cerebellum (as certain cerebellar ataxia) with severe locomotor symptoms, in which the Purkinje cells (PCs), the sole-output cerebellar neurons, suffer from degeneration. The adult regenerative capacity of neurons in mammals is extremely low. However, the zebrafish is a model organism that exhibits extensive adult neurogenesis and regeneration, and is therefore most likely to elucidate key cerebellar regenerative mechanisms that are currently unknown. The proposed project will focus on the study of PC regeneration using an inducible cell type specific ablation technique, in which the recovery of PCs cannot involve the plasticity of remaining cells, making this tool superior to existing protocols which rely on mechanical injuries. In such PC-ablated zebrafish the time course of PC layer recovery will be analyzed by behavioral tests, which will also reveal specific functions of the zebrafish cerebellum. Cellular processes of regeneration will be revealed by the analysis of double transgenic zebrafish strains addressing: the cellular sources of regenerating PC progenitors, their spatial distribution, potential migratory routes of de novo differentiating PCs, and cellular interactions accompanying a proper restoration of a functional PC layer. We also expect to obtain first insights into potential molecular processes involved in the degeneration-regeneration processes of PCs, considering Stat3- signaling (with important roles in tissue restoration) as a promising candidate to promote PC regeneration by employing inhibitor studies, and to derive functional consequences for the organism. These results are fundamental to understanding and eventually treating diseases affecting the cerebellum. Therefore, these studies about PCs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Causes and consequences of change in public opinion about Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Causes and consequences of change in public opinion about EuropePublic opinion towards European integration and the EU is divided, especially in the wake of the economic crisis. From being a consensus issue with stable and broad elite and public support across the continent, it is now a contentious issue with swiftly changing opinions. EU opinions include utilitarian considerations, identity issues, and emotions. These EU opinions matter for voting behaviour and for the future course of the EU and European democracies. The future of European integration needs public support and yet we know little about what drives and changes this support: we need to know why some people change their opinions about European integration while others do not, and what the consequences of these changes are in terms of electoral behaviour.  This project studies the causes and consequences of EU opinions. Opinions may change in response to real world developments, domestic political factors, and personal experiences, but very importantly also in response to new information such as provided by the media and in interpersonal and network communication.  This project develops and tests a Communication Model of Public Opinion Change and Consequences. The key question underlying this project is when, how, for whom, and with which consequences communication matters for changes in public opinion about Europe? To address this question, an innovative and interdisciplinary design is needed. This will be done in five integrated subprojects, bringing together research on public opinion and political behaviour from the fields of political sociology, political communication, and political psychology. It employs a range of research techniques (novel survey methodology, (automated) content analyses, social me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Faith Online: Transnational Religious Politics on New Media in India and Europe' (ONLINERPOL), addressing dissemination and exploitation.

assistant: **Impact**

This project explores new media practices in India and its diaspora in Europe, to examine the relations between the expanding Internet media and the political cultures of religious identities in the current moment of globalization. As opposed to understanding new media as discrete channels of communication or an abstract technological context that defines globalization, the project uses a unique conceptual frame of approaching the Internet as an arena of “multiple interfaces”. This frame foregrounds the profound mediation of the Internet media in bringing distinct actors, levels of authority, ideologies and motivations in close confrontation: the nation state, market, diaspora, homeland publics and divergent religious communities. Each project in the proposed program will illuminate one important strand of the interfaces, to ask how these interfaces constitute new mediated spaces of collisions and contiguities, which allow political actors within and beyond the national frontiers to negotiate and collaborate in unprecedented ways. It examines how in turn, the generative capacity of such mediated interfaces has opened up new locations, modulations and means of practice for the political use of religion, especially for interreligious difference as a political concept. It scrutinizes the implications of these developments for relations of sovereignty and citizenship, with a theoretical objective to approach the emerging confluence of religious enterprise, political conservatism and economic liberalization. To achieve the objectives, the study, in a rare methodological move, combines social media network analysis with ethnography of actual people posting the messages on online media.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Technology Pavilions at Following Exhibitions: Otc Houston, 2001; Offshore Europe, 2001; ONS Stavanger, 2002; and partial support of International Gas Research Conference 2001' under Fifth Framework.

assistant: **Concept**

To promote and increase the uptake of EC hydrocarbon technologies, which have the potential to solve current and future exploration, extraction and production challenges facing the oil industry. To identify and promote previously unknown technologies which are being developed by SMEs to meet the oil industry' s current and future challenges. SMEs are responsible for much of the innovative technology in the hydrocarbons industry. To promote the 5th Framework Programme and its role in the EU energy strategy to industry, and government policy makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Precise test of Lepton Universalty with decays of the charged kaon at the NA62 experiment at CERN' in the context of a Seventh Framework call.

assistant: **Objectives**

Lepton Universality, a postulate that the strength of weak interaction of leptons (electrons, muons, tauons) is independent of lepton type, represents a corner-stone of the Standard Model of particle physics. The origin of the apparent Lepton Universality in the charged lepton sector not associated to any known symmetry is one of the fundamental problems of modern physics, and is closely related to the concept of supersymmetry. The Fellow will perform a unique stringent Lepton Universality test by measuring the ratio of the electronic to muonic decay rates of the charged kaon to a record precision of one part in thousand in the framework of the NA62 experiment at the European Organization for Nuclear Research (CERN). Such measurement is known to be a plausible opportunity to detect the first solid evidence of new physical phenomena. The project will take advantage of the unique very intense kaon beam and recent developments of the appropriate detector technology, and bring together the Fellow's research experience in kaon physics with the extensive hardware and computing experience of the Birmingham particle physics group. A crucial part of the experimental equipment required for the measurement - the ultra-fast frontend and readout electronics systems allowing operation of the CEDAR Cherenkov kaon tagging counter in the very intense beam - will be designed, built and delivered. The relevant monitoring, calibration and analysis software will be developed, and the analysis strategy will be elaborated. A test data sample will be collected with the first high quality beam available to the experiment in 2013. Analysis of that sample will allow measurement of the detector performance, optimization of the experimental strategy, and identification of the systematic limitations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Landing Gear Noise Attenuation' (NOISETTE) under Seventh Framework.

assistant: **Objectives**

Within NOISETTE, Cenaero and VKI combine their respective expertise in computational fluid dynamics and acoustics in order to deliver a tailored solution for the aero-acoustic assessment and design of a low-noise configuration for a regional aircraft nose landing gear. The computational approach relies on performing high quality detached eddy simulations and on using the obtained noise sources for acoustic propagation.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DNA binding specificity in-vivo' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

How transcription factors (TFs) bind rapidly at specific sites within large genomes remains a major mystery. Specificity is puzzling since TFs select a small fraction of their potential binding sites - short and highly abundant DNA motifs. Rapid detection of these selected sites is challenging due to the small motif size and the large number of non-specific sites within a genome. Despite extensive efforts, a unifying model accounting for these challenges, underlying the foundations of gene regulation, is still missing. Our recent results revealed an unexpected role of long intrinsically disordered regions (IDRs) in determining the in-vivo binding specificity of TFs. Long IDRs are ubiquitous among eukaryotic TFs, but their potential role is largely unknown. By studying two budding yeast TFs, we found that in-vivo binding specificity depends on long (>500 residues) IDRs located outside the DNA binding domains (DBDs). Furthermore, IDRs direct TF binding to the selected set of promoters using multiple weak specificity determinants distributed throughout their entire sequence. Our results suggest that TFs search for their binding sites through a two-tier process: Specificity determinants distributed within long IDRs direct TFs to broad promoter regions, allowing for subsequent localized search of the DBD for its short binding motif. We plan to establish this model by: (1) Defining the molecular basis of IDR-promoter recognition and its sequence recognition code, (2) Defining the dynamic profile of IDR-based DNA recognition, and (3) Elucidating the evolutionary implications of this novel recognition mode. Through a combination of experiments, computation and theory, carried out by an interdisciplinary group of students, our study will establish a new paradigm that explains th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Indirect Search for Dark Matter Using the VERITAS Telescope Array' (UCDVERITAS).

assistant: **Concept**

Observations of the motions of stars and galaxies in large-scale structures have revealed that most (>80%) of the matter in the Universe is invisible. The nature of the “dark matter” is one of the outstanding puzzles in modern physics and experiments are underway to detect and characterize it. There are three main experimental approaches: direct detection of dark matter particles arriving from space, generation and detection of dark matter particles in particle accelerators, and indirect detection via observation of the gamma rays produced when dark matter particles decay or self-annihilate. Such gamma rays would travel from sites of dark matter density in the universe, and be observable on Earth with gamma-ray telescopes. My research proposal is to utilize very-high-energy (VHE) gamma-ray observations of candidate astrophysical dark matter sites to measure or constrain the dark matter annihilation rate, and to statistically combine the results with those from collider and other VHE telescope searches. The research will utilize VERITAS, one of the leading VHE gamma-ray observatories currently in operation, and will be conducted under the supervision of Dr. John Quinn at University College Dublin. A key component of the research will be to investigate improved analysis techniques to enhance the gamma-ray selection and background rejection image analysis techniques employed in the analysis of VERITAS data. I developed expertise with these methods during my graduate and post-doctoral work in particle physics, and am thus uniquely positioned to adapt and refine such techniques for use in astrophysics. I will also combine gamma-ray annihilation rate limits with complementary measurements from other telescopes and collider experiments to produce significantly improved constra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hacking your way to IT expertise: What digital societies can (and need to) learn from informal learning in hackerspaces', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

HACKIT will advance our understanding of how individuals acquire information technology (IT) expertise in informal learning environments. IT skills, such as coding, are crucial for economic growth in the European Union (EU). But it is estimated that there will be a shortage of 900,000 IT professionals by 2020. Women are underrepresented in IT professions in all EU countries. These issues impede the competitiveness of the European IT sector and prompt questions about its inclusiveness. In order to develop effective, inclusive educational policies and initiatives addressing this IT skills shortage and gender gap, we need answers to pressing questions: Why, where, how, and by whom are IT skills trained? The relevance of informal learning for IT professions has been emphasised in this context. Yet, empirical, particularly observational research on IT learning in informal environments is largely missing. My project will tackle this research gap by conducting a digital ethnography of ‘hackerspaces’ in the United Kingdom. Hackerspaces are key examples for informal IT learning environments: they are physical places where community members engage in activities involving coding and electronics. Misleadingly, ‘hacking’ is predominantly associated with illegal acts, but hackerspace members actually pursue legal, innovative IT practices. By ethnographically approaching hackerspaces, I will realise three main objectives: First, with participant observations, I will investigate how individuals acquire and cultivate IT skills in hackerspaces. Second, through interviews, I will examine which factors (de-)motivate members’ IT learning. Third, I will detail how my study can inform educational policies and initiatives fostering IT expertise in Europe. Overall, while I will investigate how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Microbiology of extremely acidic terrestrial volcanic ecosystems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Terrestrial mud volcanos are extreme environments with pH values below even 1, with temperatures up to 70 ºC. They represent ‘hotspots’ of greenhouse gas emissions. Despite the hostile conditions, mud volcanos harbour very unique microbial communities involved in the cycling of elements like carbon, hydrogen, sulfur, and nitrogen. Microbial communities in extreme environments are characterized by low biodiversity and as a consequence serve as good models to study linkages between genomic potential and environmental parameters. Metagenome studies have shown that most of the microorganisms in extreme environments are only distantly related to cultivated bacteria. Therefore, state-of the-art enrichment techniques using chemostat and sequencing batch cultivation with inocula from geothermal sites and driven by physiological information from metagenomic/metatranscriptomic data have a high potential to result in novel isolates. This was already demonstrated by our isolation of both mesophilic and thermophilic acid-loving methanotrophs. The aim of this project is to obtain a fundamental understanding of the microbial ecology of extremely acid terrestrial mud volcanos with special emphasis on the elemental cycles of sulfur, methane and nitrogen. After identification and isolation, the microbial key players will be investigated to unravel the molecular mechanisms by which they adapt to extreme (thermo)acidophilic conditions. To achieve this, several parallel and complementary state-of-the-art-approaches will be combined, e.g. meta-omics, microbial ecophysiology, cultivation techniques, cell biology/biochemistry, metabolism/gene expression studies. The project will profoundly increase the understanding of these natural hotspots of greenhouse gas production/degradation and newly i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Microbiota-controlled trafficking of immunosuppressive intestinal T cells into cancer' (MADCAM) under Horizon Europe.

assistant: **Objectives**

Resistance of cancers to immune checkpoint blockade (ICB) can result from a deviated taxonomic composition of the intestinal microbiota. A surge in the Enterocloster genus, for instance following discontinuation of antibiotics or chronic inflammation caused by tumors, induces the downregulation of MAdCAM-1 in the ileal lamina propria and mesenteric lymph nodes through perturbations of biliary salts. In turn, the ileal MAdCAM-1 loss induces the exodus of immunosuppressive T lymphocytes expressing the MAdCAM-1 receptor α4β7, i.e., FoxP3+ RAR-related orphan receptor gamma t (RORγt+) regulatory (Tr17) cells, from the gut to distant tumors. Disruption of the MAdCAM-1–α4β7 axis compromises the efficacy of immunotherapy and reprograms the tumor microenvironment towards a regulatory phenotype. Moreover, serum soluble MAdCAM-1 is a proxy of intestinal dysbiosis and a robust predictor of survival in cancer patients treated with ICB. To decipher the biological significance of these findings, we will first investigate the transcriptional and post-translational mechanisms regulating MAdCAM-1 expression and function (Task 1), in particular neuroendocrine and metabolic cues.  Next, a comprehensive phenotyping of the emigrating enterotropic T cells reaching the tumor by single cell transcriptomics and genomics, as well as specific genetic and immunopharmacological intervention on T  lymphocytes and cancer cells will lead to the identification of the molecular mechanisms regulating the gut-tumor axis (Task 2). We will investigate how enterotropic T cells homing to cancers maintain their proliferative and suppressive capacities, in particular in the light of the recognition of tumor and/or commensal antigens (Task 3). Altogether, this approach will lay the molecular and metabolic foundat