RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The first cybersecurity management system providing evidence based metrics for cyber risk at the business asset level in real-time' to be submitted under Horizon 2020.

assistant: **Abstract**

InnoSec’s main product, STORM, is the only Cyber Risk Management application that provides evidence based metrics defining cyber risk at the business asset level in real-time, using a flexible risk modeling method, while improving the overall user experience. STORM allows companies to answer strategic questions such as “How much cyber risk do we have?”, “How well are our assets protected against a cyber-attack?”, “What work is in progress related to remediation of cyber risk?”, “How much cyber insurance do I need?” and “What should my customer pay for cyber insurance?” STORM is designed to solve the pains of seeing the cyber risk picture across all aspects of the enterprise including the CEO/board, CISO, Compliance Manager, Risk Manager and Cyber Security Remediators. STORM, is a complete risk management framework that breaks the bounds of the traditional siloed risk management solutions and connects the dots between strategic and operational cyber. STORM allows the organization to collaborate on cyber risk management activities through information sharing, advanced analysis tools, flexible workflows, operational management, smart dashboards, a dynamic reporting engine and interaction with the existing user workspace. STORM is a comprehensive solution for cyber risk management and decision support, and provides business intelligence that enables organizations to plan, measure, manage and monitor their cyber-security posture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Navigating lymphatic formation and function  in health and disease' to be submitted under Horizon 2020.

assistant: **Abstract**

For many years, lymphatic vessels have been viewed as inert fluid conduits whose open structure allows for passive flow of antigens, proteins and cells from peripheral tissues to lymphoid organs. Yet, recent discoveries highlighting novel functions and heterogeneous origins of the lymphatic endothelium, call for reevaluation of the passive lymphatic-vessel paradigm. During the past decade, we have used the zebrafish (ZF) to detail the cellular and molecular events underlying the development of the lymphatic system. Our discoveries have greatly contributed to our understanding of the origins, specification and mechanisms of formation of lymphatic endothelial cells (LECs) in the developing embryo. In line with our past achievements, we now aim towards novel directions- to transform the adult ZF into an equally convenient model for the study of lymphatic diversity. The overall goal of LymphMap is to reveal the multiple regulatory levels that coordinate the formation and functionality of lymphatic vessels in health and disease. To this end, we will carry out a comprehensive research program characterizing four distinct aspects of lymphatic biology: 1.Cellular origins and molecular signature of LECs2.Formation and specialization of organotypic lymphatics 3.Lymphatic vessels during organ regeneration 4.Lymphatic involvement in human disease Our experimental strategy involves the combination of high-resolution imaging, global expression profiling and regeneration models in adult ZF, with analyses of human-derived LECs in various clinical settings. The important and unique aspects of our approach are the focus on in vivo dynamics, and the cross-organ comparative analysis, which will likely provide the much-needed knowledge on lymphatic diversity in health and disease. When comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovation Management Platform for Aeronautics' under Seventh Framework.

assistant: **Concept**

The aim of the proposed project is to develop a software-based innovation management platform founded on structured and precise innovation management processes in order to: generate, assess, define and schedule industrial innovation projects which will lead to step changes in aeronautics. To continuously capture and maintain knowledge output of innovation processes, a regularly accessible database will be integrated into the platform. The platform will be web- and work-flow based and developed by the latest Microsoft .NET and SQL Server technologies. The project consortium consists of innovation and aviation experts from Altran (co-ordinator), Altran NEO, Micos, Carl Zeiss, and EADS. Upon reaching the innovation process chain and the corresponding IT platform development milestones, a real-case process will be launched to apply the IT platform to current challenges of the aeronautics sector in order to generate, assess, track, and – in long-term – implement resulting step changes, leading to increased competitiveness of the European aeronautics industry. Hence, the project target is to keep innovation leadership in Europe by enhancing sustainable innovation - based on a mix of incremental and breakthrough changes –enabled by the newly developed innovation platform and modern, systematic innovation management methods. The benefits of the platform will be: business process integration, increasing innovation efficiency (goal-oriented, systematic and model-based approach), fostering continuous and process-flow based collaboration, and establishing a database to efficiently manage knowledge. The IT platform will be incorporated at industrial partners as well as provided to selected universities by constantly involving researchers / specialists from within and outside the aer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preparation of novel materials by filling carbon nanotubes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The remarkable physical properties of carbon nanotubes (CNTs), have led to much interest in the potential for their application in many diverse directions. There are many examples in which the cavity of CNTs has been filled with a variety of compounds, including organic molecules, fullerenes, inorganic salts, water and metals.    The aim of this project is to prepare new nanomaterials by filling CNTs and explore their potential applications. The method used to fill steam purified and opened CNT will depend on the characteristics of the material to be encapsulated, being the most commonly used routes the solution filling, melting filling and vapour filling.    We propose to optimise the process for the filling of carbon nanotubes and the removal of the external material (from the filling experiment); to prepare and characterize nanoscaled materials which properties can differ significantly from the bulk material, and to fill carbon nanotubes with materials of interest for medical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Galileo-EGNOS as an Asset for UTM Safety and Security', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The GAUSS project aims fast and thorough achievement of acceptable levels in terms of performance, safety and security for both, current RPAS  and future UTM operations. UTM helps control, manage and integrate all RPAS in the VLL airspace to ensure the security and efficiency of UAS operations. The key element within GAUSS is the integration and exploitation of Galileo-EGNOS exceptional features for precise and secure positioning. These features will enable not only safe, timely and efficient operations but also coordination among a higher number of RPAS with  appropriate levels of security, as it provides anti-jamming and anti-spoofing capabilities. Multi-frequency and multi-constellation solutions will be exploited with this purpose. GAUSS will increase resilience in UTM operations and, at the same time, ensure UTM coordination capabilities to increase the number of platforms that can share the same airspace. Precise coordination among UAS in the air, together with individual high precision and secure positioning are key for the safety of the operations and therefore for the success of UTM. The UTM infrastructure will also benefit from the GAUSS Galileo-EGNOS based ADS-B solution and encrypted air-ground communications. GAUSS includes the definition, negotiation and execution of safe trajectories both in normal operation and in case security or safety is compromised. The GAUSS systems will be validated with two field trials (in-land and sea) with the operation of 4 UTM coordinated RPAS with different types (fixed and rotary wing) and EASA operational categories. The outcome of the project will consist of Galileo-EGNOS based technological solutions to enhance safety and security levels in current RPAS operations and future UTM based operations. Increased levels of effi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Injection Moulding Production Technology for Multi-functional Nano-structured Plastic Components enabledby NanoImprint Lithography' in the context of a Seventh Framework call.

assistant: **Objectives**

Micro- and nanometer structuring has proven to be an efficient method to functionalize surfaces, and is attractive to manufacturers of plastic products. Plastic components are volume manufactured by injection moulding. Compact Discs and Digital Video Discs are today manufactured with nanometer range lateral resolution but, only on planar surfaces. Free-form (double-curved) moulding tools today offer resolutions down to 100 μm, limited by the methods used for creating the injection moulding tools.The objective of the project is to upgrade existing injection moulding production technology for manufacture of plastic components by enhancing the lateral resolution on free-form surfaces down to micro- and nanometer length scales. This will be achieved through the development of a complete nanoimprint lithography solution for structuring the free-form surface of injection moulding tools and tool inserts. This will enable a cost effective and flexible nanoscale manufacturing process that can easily be integrated with conventional mass production lines.The proposed technology enables functionality of plastic surfaces by topography instead of chemistry. This will significantly simplify the introduction of new products to the market, safer to produce and use. The proposed technology allows production of plastic surfaces with several different functionalities using the same material. This simplifies recycling and supports a cradle-to-cradle production philosophy.The proposed technology will be developed to meet specific industry demands from partners representing the plastic industry including the automotive, lighting and toy industries. During the project the European Trade Organisation representing the European plastic industry will disseminate the PLAST4FUTURE technology towards
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exploiting Cellular Metabolism to Develop the Next Generation of mTOR Inhibitors' in the context of a Horizon Europe call.

assistant: **Objectives**

The mTOR (mammalian/mechanistic Target of Rapamycin) kinase, as part of the mTORC1 and mTORC2 protein complexes, is the master controller of cellular and organismal physiology. Dysregulation of mTORC1 activity is tightly linked to human disease and ageing. Consequently, mTOR inhibitors have been tested in various clinical settings, however with little success and limited applicability so far, mainly due to low efficacy or adverse effects, thus highlighting the need for more potent and more specific compounds. For instance, the phosphorylation of most mTORC1 targets is resistant to rapamycin and its analogs (rapalogs). Furthermore, catalytic mTOR inhibitors demonstrate increased toxicity and cause unwanted metabolic effects mainly because they also block mTORC2 activity. We have recently identified malonyl-CoA, a metabolic intermediate of fatty acid biosynthesis, as a novel specific mTORC1 inhibitor in cells that shows improved characteristics over existing compounds as it blocks phosphorylation of all mTORC1 targets without affecting the activity of mTORC2 or other related kinases. Using our biochemical, structural and computational data as the basis for targeted compound development, we aim to develop synthetic malonyl-CoA derivatives as a new class of mTORC1 inhibitors with improved specificity and effectiveness. Because of the well-established role of mTORC1 in ageing and disease, these inhibitors are expected to be of profound scientific, clinical, and commercial interest.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Application of Advanced Raman Spectroscopies to the Quantitative Analysis of Industrial Chromatography Columns' under Horizon 2020.

assistant: **Concept**

Dr. Kevin Buckley (KB) was awarded his PhD from University College London (UCL) in 2011. At UCL he had worked to develop Raman spectroscopy as a tool for bone-disease diagnosis and he subsequently took a position as a Laser Spectroscopy Scientist, at the Rutherford Appleton Lab (RAL) in Oxfordshire, England, to continue this work. After leaving RAL, KB moved to the University of British Columbia (UBC) in Vancouver, Canada. At UBC he worked to develop a Raman spectroscopy-based instrument for detecting chemical changes in (donated) human red blood cells as they age in plastic blood-bags. He has recently (Aug 2015) returned to his home country of Ireland and the primary aim of the proposed Marie Skłodowska-Curie Fellowship is to reintegrate him with the research community there. The primary scientific objectives of the fellowship to develop novel analytical methods based on Spatially Offset Raman Spectroscopy (SORS) for applications in biopharmaceutical manufacturing. It is proposed that this interdisciplinary research take place under the supervision of Dr. Alan Ryder (AR) in the Nanoscale Biophotonics Lab (NBL) at the National University of Ireland, Galway. The combination of KB’s SORS expertise with AR’s biopharma expertise has the potential to deliver innovative science; KB is one of the few researchers in the world who has years of experience with SORS of complex materials (he trained under the inventor of SORS, Prof. P. Matousek FRSC, at RAL) and AR is an international leader in the development of quantitative analytical methods for biopharmaceutical manufacturing processes. In addition to scientific objectives, the fellowship programme has been designed to develop KB’s career and enhance his ability as a scientist. He will be provided with opportunities to develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cell Maintenance the Cell Death; Symposium on Mechanisms of Cell Death' (1998-2002).

assistant: **Concept**

The Symposium on Mechanisms of Cell Death, entitled 'Cell Maintenance and Cell Death, will be co-organized and co-hosted by the International Cell Death Society, a non-profit scientific organization based in NY, USA. The meeting is an example of the society' s efforts to help promote interaction and collaboration among scientists working in various subspecialty fields of apoptosis. This is the first European edition of the meeting, scheduled in a year in which there are no regular dedicated meetings on apoptosis (the Keystone, Gordon, and CSHL meetings in the USA), and will be the main occasion for cell death scientists to meet and discuss recent developments in this rapidly advancing field. Scientists from many research backgrounds will examine cell death in a multidisciplinary fashion, with interaction among neurologists, immunologists, developmental biologists, oncologists, and gerontologists from American and European groups.Broad topics such as cell death in aging and development, which are often not addressed in limited-focus meetings, will be addressed specifically and in the context of three currently important topics in the field: intracellular localization and translocation of molecules that affect apoptosis, autophagocytosis, and phagocytosis. Focus is on the concept that cells live perpetually amid signals encouraging maintenance, proliferation, or death, and that effective communication of this information determines cell fate. The impact of failure in disease situations will be emphasized, and individual sessions will draw parallels among signalling mechanisms in diverse tissues such as thymocytes, neurons, malignant cells, and cells under the control of viral genes. The approach focuses on processes, asking participants to consider common elements and to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A novel bioreactor for biological treatment of hydrocarbon oil polluted waters' to be submitted under Fourth Framework.

assistant: **Abstract**

The contamination of industrial wastewater, surface water and ground water by oil is a particularly serious environmental problem. Oils are extremely difficult to break down by chemical or biological methods. Hydrocarbon oils tend to float on water and attach to solid surfaces. Due to these properties of oil when in contact with water, the contamination of oil in water can have disastrous environmental impacts on all forms of marine and aquatic life. Conventionalphysical techniques, based on the static separation of oil water, are ineffective. They do not remove all of the visible oil, and the levels of residual oil in the treated effluent are too high. It is the purpose of the proposed project to design and develop a novel bioreactor for biological treatment of hydrocarbon oil polluted waters. This novel bioreactor will be able to effect simultaneous separation, adsorption and biodegradation of hydrocarbon oils in wastewater, surface water and ground water. This project progresse as far as the design and build of a pilot plant to test this novel technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MADS box transcription factors: interactions between metabolic pathways and seed development' (METMADS) targeting Seventh Framework.

assistant: **Abstract**

Seed development is a complex process that requires the coordination in growth and development of the integuments, the embryo and the endosperm. The roles of integuments in seed development as well as the cross talk between the maternal tissues (the integuments) and the fertilization products (the embryo and the endosperm) represent intriguing arguments since many years.MADS-box genes have been thought to be involved in development and identity determination processes. However, there is scanty information regarding their roles in seed development. Recently it has been shown that MADS box factors like SEP3 and AP1, regulate the expression of genes controlling metabolism as well as cell elongation and proliferation. Recently the host lab has demonstrated that the MADS box transcription factor STK, besides being involved in different aspects of ovule and seed development is also controlling the expression of genes involved in polysaccharides and flavonoid metabolic pathways. STK forms a multimeric complex with other MADS-box proteins. Two of them, GOA and ABS are also involved in seeds development.Based on these results, the aim of this proposal is to employ advanced techniques like RNA seq, ChIP seq and metabolomics analysis to identify  molecular links between differentiation and metabolism.  The stk, abs and goa single mutants will be analyzed in detail and used for metabolomic analyses. The transcriptomes of immature seeds of three single mutants will be compared with wild-type. This analysis will allow the identification of genes that are putatively regulated by the three MADS box factors. STK ChIP-seq analysis will be performed which will contribute to find new STK target genes. The overall data will allow connecting development to metabolism.The novel proposed resea