RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable downstream processing of vaccines through incorporation of nanobiotechnologies : novel affinity ligands and biomimetic membranes' (DiViNe) under Horizon 2020.

assistant: **Objectives**

In the vaccine industry, downstream processing is of extreme importance. Prophylactic vaccines aim at protecting healthy people, so any contaminant has to be discarded with the most drastic measures. Such « negative » approach comes at the expense of the recovery of product : yields are poor, thereby inducing a high product cost. Processes are also complex, since they rely on multiple eliminations rather than on recovery of the unique product of interest. Technically, this is mostly due to the lack of specific capture systems that would allow direct, « positive » separation of the vaccine from its environment.Vaccines know no borders. For developing countries, the pressure on costs is even more acute, and local production is a way to try to reach the 1$ per dose target. In this context, water sustainability is a major issue, as it is a most sensitive ingredient in bioproduction.DiViNe will tackle theses cost and environmental issues with technological answers. The partners will combine two major Nano/biotechnology innovations to develop an integrated purification platform amenable to the different natures of vaccines : glycoconjugates, protein antigens and enveloped viruses. They will implement Nanofitins (novel affinity capture ligands) and Aquaporin-based membranes (energy-saving nano-biomimetics used in the cleantech industry), for a « positive » purification approach. High yields are expected (data from antibody purification with Nanofitins), at affordable cost of goods and with a sustainable approach of water recycling.Novartis Vaccines brings to the Consortium a broad range of targets, and identical strategies can be applied for biopharmaceuticals in general. The development custom affinity capture processes as a sustainable platform is therefore economically rele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Radiation-detected NMR: new dimension for Magnetic Resonance spectroscopy and imaging' to be submitted under Horizon Europe.

assistant: **Abstract**

Nuclear magnetic resonance (NMR) is a powerful spectroscopic technique, used in various fields, including chemistry, biology and medicine. However, conventional NMR has one big limitation, namely very small sensitivity, due to a low level of polarisation of nuclear spins and inefficient signal detection by an induction signal in pick-up coils. My ERC Starting grant has explored the use of radiation-detected NMR (RD-NMR), in which very short-lived nuclei were used as novel NMR probes, bringing up to a billion-fold increase in NMR sensitivity. Such nuclei are produced at a radioactive-ion beam facility and are polarised on the fly, before being introduced into the sample. In this Proof of Concept project, I want to use the advantaged of RD-NMR and explore the prospect of turning it into a more easily accessible analytic tool. I aim to build a prototype of a modular insert for conventional NMR and MRI spectrometers that will allow in-situ polarisation of longer-lived nuclei that can be acquired commercially. The insert will include a sample, rf coil for spin excitation, beta-particle detectors, connections to introduce the hyperpolarising agent and the radiolabelled molecule that will be polarised in situ. The insert will be complemented by hardware and software needed for the data acquisition. During the project we will also explore the most suitable exploitation path, we will refine the end users and end market (including a workshop at CERN), and will investigate the patentability of the results. I will collaborate with researchers from University of Mainz, Knowledge Transfer specialists, and companies active in NMR and MRI.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Advanced Capacity and Demand Management for European Network Performance Optimization'.

assistant: **Innovation**

CADENZA aims at developing a detailed trajectory broker concept for the European network, incorporating advanced demand-capacity balancing mechanisms. It builds upon the findings of the 2019 Jane’s-ATC-Innovation-award-winning SESAR Exploratory Research project COCTA, as well as upon latest industry developments. The trajectory broker will balance capacity and demand through a coordinated capacity provision process and collaborative trajectory management (including a novel trajectory charging scheme). CADENZA covers all areas of capacity provision (en-route, terminal area, and airport) as well as all temporal levels (strategic, pre-tactical and tactical). Based on previous research we expect significant improvements in cost-efficiency as well as positive impacts on other key performance indicators, especially delays.The CADENZA concept will be thoroughly validated, using mathematical models and comprehensive real-world trajectory data. Sensitivity analysis will incorporate non-nominal conditions as well as different assumptions with respect to the overall air traffic management framework, e.g., different levels of flexibility in capacity provision. Moreover, a high degree of stakeholder involvement – including an industry expert panel and stakeholder workshops – ensures practical relevance.


**Keywords:** ATM, network, performance, demand, capacity, balance, trajectory, broker, management, optimisation, validation, stakeholders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MOmentum and position REsolved mapping  Transmission Electron energy loss Microscope' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

A major mission of condensed-matter physics is to understand material properties via the knowledge of the energy vs. momentum (q) dispersion and lifetime of fundamental excitations. Unfortunately, none of the available techniques can be applied to emerging nanomaterials: inelastic x-ray scattering & electron energy loss spectroscopy (EELS) in reflection lack the spatial resolution whereas EELS in transmission electron microscopy lacks the needed combined spatial, energy & q-resolution. In MORE-TEM, we develop a new spectrometer enabling to map excitations q-resolved with 0.01 Å-1 resolution and q-averaged down to atomic level, at unprecedented 1 meV energy resolution and at variable temperature between 700K & 4K. This breakthrough is possible by bringing together our synergy group with complementary skills in electron microscopy, electron optics, experimental & theoretical spectroscopy. This opens the so-far unexplored possibility to investigate dispersion and lifetime of phonons, plasmons & excitons in nanomaterials including (organic) molecules, 1D nanotubes, 2D materials, heterostructures & nanocrystals in minerals with a few nm of lateral resolution on samples as thin as an atomic monolayer. Mapping out the spatial and q-landscape of primary excitations will allow us to gain control on quantum phases, like charge-density waves and superconductivity, to engineer new materials for energy (e.g. batteries), (opto-)electronic devices in (organic) electronics, and to model the physical and chemical properties of natural geological systems. This will hugely impact a wide range of applications in physics, chemistry, engineering, as well as in environmental-, geo- & material science. MORE-TEM not only implements features of a large scale facility on a cheaper table-top instr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A game changer for the treatment of osteoarthritis: a cost effective combined advanced therapy to treat knee osteoarthritis'.

assistant: **Innovation**

According to the WHO Osteoarthritis (OA) is one major course of years lived with disability in the elderly and considered a high burden disease, which makes it a research priority in Europe. There is no cure for OA and SoA treatments need to be reconsidered. Current pharmacological interventions consist of analgesic, anti-inflammatory drugs as well as intraarticular steroids and hyaluronic acid (IA-HA) with moderate efficacy and associated long-term side effects. New medications are thus needed both to alleviate pain and slow down disease progression. Taking advantage of the explosion of RNA technologies in the last years, SINPAIN aims to develop a pipeline of siRNA-based therapy built on the combination of current technologies (dyanmic IA-HA and nanocarriers) that will be designed step-by-step in order to reach a successful management of inflammation and innervation therapy for the treatment of early (grade 0-1) and later stages (grade 3-4) of knee osteoarthritis (OA). To do so, a nanoformulation composed of functional IA-HA that can be loaded with vectors, for the delivery of siRNA targeting IL1? and NGF, and nanocarriers will be developed. In parallel, large effort will focus on understanding the pathological mechanisms of OA. To validate efficacy in relevant potency assays, 3D coculture models will be developed with human cells and tested in unique bioreactors mimicking joint environment and biomechanics. With the identified cell targets, IA-HA will be modified with immunomodulator peptide which will activate the adaptive immune response, responsible for OA regeneration. The 4 pipeline products of SINPAIN will be validated in vivo in a relevant OA model with SoA techniques that will demonstrate the reduced inflammation and pain, as well as the cartilage regeneration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The future of European fisheries and aquaculture research', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The goal of the project is to define the research required in the medium term (10 years), to enable exploitation and farming of aquatic resources in the context of key challenges and risks for meeting sustainability requirements. The main output of this exercise will be a publication outlining the key challenges, strategic options and research needs concerning fisheries and aquaculture in both European waters and waters in which European fleets are operating under European agreements. The project will contribute to the implementation of a future Maritime Policy and to further strengthen the European Marine Research Area through better anticipation of research needs in the field of fisheries and aquaculture. The principle aim of FEUFAR is to in a 20 months period: 1. provide a 'state of the art' inventory of existing foresight analyses world wide, including the distillation of key messages, identifying themes, threats, drivers and developments in science and policy. 2. build scenarios, taking into account interactions between ecological, economical and societal factors. 3. define key challenges, strategic options, as well as paths toward a more sustainable future and following research needs. 4. by organising a platform for discussion, generate input from all relevant parties (fisheries and aquaculture sector, research institutes, policy makers) to this process, substantiating the analysis and simultaneously generate support to the outcome. Dissemination of both the outcome and the steps of the process through such means as publications, leaflets and a website will be undertaken. FEUFAR will seek the opinions of relevant stakeholders and it will consider the possible implications of long-term or sudden climate change, new technologies, changes in societal values and orga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Quantitative T cell Immunology and Immunotherapy' to be submitted under Horizon 2020.

assistant: **Abstract**

Health and disease are regulated, to a large extent, by our immune system. The immune system not only protects the body from infectious disease, but is involved in a number of conditions of increasing incidence and morbidity, such as diabetes, rheumatoid arthritis, inflammatory bowel disease and allergies. In cancer, the immune system can be both cause and cure; it contributes to chronic inflammation that promotes tumour development, but it can also provide the ultimate weapon against metastatic disease. Thus, the development of ways to harness, direct or restrain immune responses has great potential for enhancing human health. Understanding the mechanisms that control the abundance of different lymphocyte (a type of white blood cell) subsets is key to therapeutically targeting immune responses.  Ultimately, this understanding must be sought in quantitative terms, explaining how the rates of cell proliferation, differentiation, survival and death are determined by molecular mechanisms and cellular interactions. Current immunological research is beginning to combine experimental approaches with mathematical analysis to quantitate immune dynamics.  A severe obstacle to more rapid progress in this area is the lack of appropriately trained scientists.  In this ETN, European scientists, with a rich track record in collaborative research and training, have come together to deliver a highly collaborative, multidisciplinary and intersectoral research training programme for 15 early stage researchers (ESRs) in Quantitative T cell Immunology and Immunotherapy (QuanTII).


**Keywords:** adaptive immunity,  application of mathematics in sciences,  biological system analysis: modelling and simulation,   computational biology,  biostatistics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'REVOLUTIONIZING STATIONARY ENERGY STORAGE COST: Pilot Plant and Go To Market Plan For Zn-ion Rechargeable Batteries', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The global market for Stationary Energy Storage is estimated to reach a value of €26 billion by 2022, with a compound annual growth rate (CAGR) of 46.5 percent, fueled mostly by the rapid growth of Renewable Energy Sources (RES), which are dependent on energy storage technologies to be competitive despite their intrinsic intermittence. However, significant challenges remain when it comes to reaching the low-cost levels at which storage technologies combined with RES become competitive with the traditional electrical grid, while also remaining environmentally friendly. Enerpoly’s Zinc-Ion battery cell technology represents a breakthrough in Stationary Storage, by offering a simple, environmentally friendly, efficient, durable and low-cost alternative to Lead-Acid and Lithium-Ion batteries- today’s most widely used storage technologies.Besides storing renewable energy, Enerpoly’s technology can be used in many uninterrupted power supply (UPS) applications at grid, industrial, commercial and even residential levels. Some examples are peak shaving, datacentres, powering telco equipment and commercial and residential storage of renewable energy. ENERZ, Enerpoly’s main product, will allow battery manufacturers to reduce their current costs by more than 50% for the same kWh storage capacity when compared to Lead- Acid and Lithium-Ion batteries, with a longer cycle life and improved safety.Thanks to this project, our revolutionary technology will enter the market in 2022 in collaboration with leading European battery manufacturers.


**Keywords:** Energy storage,  battery technology,  cell technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Low cost, wireless vibration monitoring system based on rfid/mems and bluetooth technologies' (LCWVMS).

assistant: **Innovation**

In today's highly competitive market place, the costs associated with unexpected machine failure can have a drastic effect on a company. There is a need for monitoring the condition of rotating machinery within process plants including pumps, gearboxes and motors to carry out preventative maintenance of the plant at a cost that does not represent a major barrier for the uptake of the benefits of condition monitoring in SME's.The aim of the proposed project is to investigate, develop and validate a new, low cost, wireless prototype vibration sensor suitable for use as a stand-alone device or incorporated within a centralized control system. The proposal is based on the novel integration of radio frequency identification (RFID) /microelectromechanichal systems (MEMS ) together with wireless communication technology in industrial applications, such as Bluetooth.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'IST-Africa Initiative 2014 - 2015', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The main objectives of IST-Africa (2014 – 2015) are to· Support implementation of Information Society, ICT and Innovation related aspects of the Africa – EU Strategic Partnership and associated dialogues between the European Commission (EC) and EU Member States with the African Union Commission (AUC), African Member States and other Key Regional Organisations· Foster partnerships between EU and African organizations in collaborative ICT Research and Innovation within Horizon 2020 & other relevant programmes· Strengthen Increased Co-ordination at EU level with Horizon 2020 instruments (such as BILAT, INCO-NET and ERA-NET) as well as relevant EU Member State and Associated Countries Programmes to promote international Cooperation<br/>IST-Africa (2014 – 2015) will achieve these goals by building on IST-Africa's existing relationships, extensive international network, insight, credibility and goodwill to· Strengthen international cooperation by promoting Information Society, ICT and Innovation related research cooperation between African and EU organizations under Horizon 2020 and other relevant programmes· Organise the IST-Africa 2014 and IST-Africa 2015 Conferences in IST-Africa Partner Countries to facilitate international community building, partnership development and knowledge sharing with activities including two IST-Africa international research conferences and two IST-Africa Living Labs Thematic Working Group Meetings· Organise Living Labs Participatory Workshops in IST-Africa Partner Countries to support cross-border knowledge sharing and wider adoption of Living Labs and Open Innovation· Organise Horizon 2020 Training Workshops in IST-Africa Partner Countries to promote African participation and identify/validate national research capacity and priorities· Organis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'An innovative approach to improving the performance of the hydraulic ram pump for rural water supply'.

assistant: **Objectives**

The hydraulic ram pump, a type of water pump that requires no external energy supply, has been in use around the world for over200 years, providing water in rural communities. This proposal outlines novel, and innovation research that will result in a major step change in ram pump performance and in its applicability within and throughout the EU. The engineering research will take an inventive approach to the ram pump, making use of modern theories on fluid flow, and will also consider the appropriateness of novel materials in combination with improved valve performance. The proposed research has considerable technical risk, but promises considerable benefits. These include: improved water output; reduced shipping costs; and applicability over a wider range of sites than is currently possible and will result in a one-size-fits-all pump."