RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of highly specific enzymes for genome manipulation' in the context of a Fifth Framework call.

assistant: **Objectives**

Efficient exploitation of genome information will, among others, depend on our ability, to sequence-specifically modify genomic DNA in vivo. A consortium of 8 academic and 3 industrial units will engineer end nucleases and DNA methyltransferases of programmable specificities which can cleave or methyl ate a single site in a DNA as complex as the human genome. The ability of the enzymes to induce gene replacement or gene silencing by DNA cleavage or cytosine-methylamine, respectively, at predetermined sites will be explored. The project involves coupling of oligonucleotides (Dons) and peptide nucleic acids (Pans) to the N-or C-termini of the C5-methyltransterase Messy and a single-chain derivative of the restriction end nuclease Purim. The covalently attached Dons and Pans will serve as affinity tags to direct the enzyme to specific sequences in the genome. Methods will be developed to introduce the enzymes into cells. Conditions for avoiding enzyme action at non-specific sites will be explored. Development of enzymes of such high specificity should greatly enhance our ability to manipulate genomes and may lead to medical applications e.g. in gene therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

BIOGEL is set up to educate young scientists to develop innovative hydrogel chemistries and systems for biomedical applications. The first objective is to provide a platform for young researchers to undergo a well-rounded PhD education, particularly focussed on translational skills for a career focused in biomedical research and medical technology development. The second objective is to engineer functional and responsive hydrogels, which resemble specific properties of the extracellular matrix. The third objective is (i) to enhance the efficacy of medical devices by 2D biointegrative coatings that direct and orchestrate the interface to living cells and tissue and enable improved integration within the body, (ii) to advance therapeutic measures by 3D templates for tissue repair, and (iii) to enable new diagnostic tools by responsive diagnostic hydrogels. BIOGEL follows an international, interdisciplinary, and intersectoral approach organized in 9 and 8 interwoven work and training packages respectively. The training and research parts are focused on synthetic and biohybrid macromolecules to build clinically translatable hydrogels with specific, application directed bioactivities. In order to enable efficient biohybridisation and minimal invasive application, emphasis is set on in situ gelation of precursors that do not affect the viability of cells and living tissue and that can interlink bioactive subunits to stimulate tissue regeneration, and serve as a functional component in biomedical devices. Structural incorporation of such units must be flexible, dynamic, and responsive to stimuli. This is directed to enhance cell behavior and receptor interaction, tailor the mechanical properties, and enable spatial, temporal, and topographical control of functional components.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Self Conversation in Virtual Reality Embodiment to Enhance Healthier Lifestyles Among Obese People' (SOCRATES) targeting Horizon 2020.

assistant: **Abstract**

ContextAccording to the WHO, approximately 23% of women and 20% of men are classified as obese. Approximately 69 billion euros is spent on healthcare issues related to dealing with overweight or obese patients in Europe every year.Obesity not only increases the likelihood of many physical illnesses, such as diabetes and coronary artery disease but can also provoke mental health issues such as stress and depression.There is a substantial unmet need to help reduce both the economic and public health burden of obesity.Problem: Current treatments for obesity have limited effectiveness.Treatments for obesity focus on trying to develop a behaviour change in the patients, predominantly trying to change their diet or take more exercise. However, these treatments have shown to be largely ineffective with most patients failing to lose weight in the medium to long term.Telemedicine has been proposed as an alternative to this, with some Virtual Reality solutions beginning to penetrate the market. However, these solutions are essentially the same lifestyle behaviour change treatments in a VR environment. Over time, the patient returns to their previous weight.SolutionconVRself is a VR platform that uses embodiment to treat obesity, by allowing the patient to see and interact with themselves. This allows them to target three aspects that are inherent with severe obesity:-Recognition -Self stigmatisation -Self determination conVRself allows patients to tackle the root causes of their obesity, rather than simply treating the symptoms.Project ScopeSOCRATES will:-Adapt the conVRself technology for treating obesity in a clinical setting-validate the efficacy of embodiment technology in treating obesity-use conVRself as a proof of concept for using embodiment techniques as a treatment for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Unique machine to produce a revolutionary RFID TAG'.

assistant: **Concept**

Current identification technologies have several limitations. Bar codes need to orient each item towards a reader. Current inlay tags and coupled tags are expensive, too thick for imbedding applications, and polluting due its manufacturing process and its disposal based on PET slips small to recycle. Common problem is their low reading accuracy, and long & expensive projects needed to redesign new RFID antenna. Currently there is no cost-effective RFID manufacturing machine neither optimised tag solution. To overcome those limitations, FABELE Srl., Italian company of 20-years expertise in RFID technology, developed & manufactured a breakthrough in RFID devices, SNAPTAG machine & Zorro tag. SNAPTAG is the first office machine to manufacture, in the easiest & most competitive way, innovative smart RFID Zorro tags, for new applications. SNAPTAG allows a cost-effective tag production, 78.000 €/unit, compared to traditional equipment for tags labelling & encoding (up to 1M €/unit); low operation cost (0,01 €/tag); strong economic benefits saving up to 55% of tags expenditure; short payback period: 12-24 weeks; unattended production (easy to operate); and reliable performance test on-production line. Zorro tag design allows to correct detuning effect, multiple tag reading up to > 20 m distance in a wide range of frequencies (UHF: 860-960 MHz). It has an unmatchable adaptability & flexibility for immediate prototyping thanks to the fast and low-cost modification of the antenna dimension.; it is cheaper & disposable: 0,03€/unit; and is a green tag supported on biodegradable paper. SNAPTAP successful launch will be by 2020, and after 5 years we will sell 208 SNAPTAG units, 888M antenna units, and RFID consultancy services, that will be worth 47,25 M€, with an accumulative profit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Venomics In Predator-prey Systems' under Horizon 2020.

assistant: **Concept**

Marine invertebrates are a rich source of bioactive compounds, including complex venoms that are highly effective and specific, having evolved through million years of natural selection. Despite their potential for drug discovery, chemical diversity of animal venoms is largely uncharacterized. Recent venomics research led to important technological advances: it is time for an expansion to neglected organisms that could lead to the discovery of compounds with novel biological activities. The main goal of VIPS Project is to address the biochemical diversification of two previously untapped marine predator-prey systems involving an Anthozoan and a corallivorous snail, both producing toxic secretions. The Researcher will be integrated into the research environment of the Université de Montpellier, where the integration of different research fields  (including genomics, proteomics, molecular evolution, peptide synthesis, and electrophysiology) will be used to discover and functionally characterize new bioactive compounds, define their interactions, highlight their evolutionary role and, through secondment, valorise their applicative potential. Focusing on venomous predator-prey couples is an innovative approach that will facilitate the identification of biological activity and evolutionary role of venom components. Wide diffusion of the VIPS Project will be ensured through open access to publications and data, and a variety of communication activities for the lay public that will exploit the appeal of predator-prey systems to highlight the link between basic and applied research. The activities of VIPS Project perfectly complement the background of the Researcher, allowing the achievement of full control over all stages of venomics research, and the development of new transf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Catalytic META C-H ACYLation of arenes' (METACYL) under Horizon 2020.

assistant: **Objectives**

Carbonylative C-H activations can lead to an unprecedented degree of molecular sophistication by combining the atom-economical insertion of CO with the green activation of unreactive C-H bonds. In striking contrast to ortho C-H acylation of arenes and heteroarenes (directing-group strategy) and para C-H ones (Friedel-Crafts chemistry), meta C-H acylations are almost completely unexplored. This proposal aims at the development of the first example of meta C-H acylation via mild carbonylation of arenes. Pivoting on this breakthrough, it will be possible to accomplish synthetic methods 1) for the efficient synthesis of hardly accessible organic compounds, 2) for the activation and carbonylation of meta C(sp2)-H bonds, 3) by employing transient directing group and 4) demonstrating the application of these protocols under continuous flow conditions.


**Keywords:** C-H activation, acylation, carbon monoxide, palladium, sequential reactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Predicting Response to Depression Treatment'.

assistant: **Innovation**

The objective of the Predicting Response to Depression Treatment (PReDicT) project is to conduct clinical, health economic and commercial research to validate the clinical performance and to complete the pre-commercial development of the P1vital PReDicT Test (formerly the eHealth P1vital® Oxford Emotional Test Battery (eH-ETB)), a novel medical device to improve the treatment and management of depression in clinical practice. On completion of the PReDicT project, the P1vital PReDicT Test will be ready for market launch. Depression is a common, serious and in some cases life‐threatening condition, affecting around 350 million people in the world and 11% of EU citizens suffer from depression at some point in their life. It takes 4-6 weeks after starting antidepressant treatment before a physician can detect whether the treatment is working, the majority of patients with depression do not respond to the first treatment they are prescribed and it can take several months before an effective treatment is identified. During this time a patients’ ability to work and function socially is severely impaired, and they can spend many weeks or months absent from work placing a substantial burden on the economy and healthcare resources. The P1vital PReDicT Test addresses this problem by identifying within 1 week of starting treatment whether an antidepressant is working or not which can significantly reduce the time required to identify an effective treatment.  Patients benefit from this by returning to good mental health sooner. The aggregated economic cost of depression in the EU is €92 billion, amounting to 1% of the total European gross domestic product.  It is estimated that the P1vital PReDicT Test has the potential to reduce these healthcare and economic costs by more than 10%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Probing the origin of intergalactic magnetic fields and cosmic rays with gamma-ray cascades' (GammaRayCascades).

assistant: **Innovation**

The existence of an intergalactic magnetic field (IGMF) remains elusive and only upper limits on its strength are known from limits on the rotation of polarization angles of radio waves. Its measurement would provide crucial information about large scale structure formation, since the IGMF is thought to act as a seed field for magnetic fields in galaxies and galaxy clusters, how the Universe evolved, and how charged cosmic rays and electromagnetic waves propagate through intergalactic space. Here, I propose a new search for IGMF signatures using observations of a high-energy gamma-ray cascades from distant galaxies. Gamma rays interact with background radiation fields to produce electron-positron pairs. These pairs up-scatter cosmic-microwave photons to gamma-ray energies, initiating the cascade. The IGMF morphology is imprinted on the cascade through a deflection of the pairs in the IGMF. A novel combination of observations with imaging air Cherenkov telescopes and the Fermi Large Area Telescope, using both spectral and spatial information, combined with precise model predictions of the cascade, promise an unprecedented sensitivity for detection of the cascade signal and the IGMF. Strong constraints on the IGMF strength will be possible if no cascade is detected.Furthermore, I will also search for a gamma-ray and neutrino signal from cascades initiated by cosmic rays from active galaxies. This will yield an independent probe of the IGMF and, additionally, constraints on the cosmic-ray acceleration power of such galaxies. As part of this work, I will also make predictions how the future Cherenkov Telescope Array (CTA) can further improve the detection of or constraints on the IGMF and the cosmic-ray acceleration power of active galaxies. This will result in an optimized
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Network of the european program in quantitative economics' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The EDP Network is composed of seven university institutions: -Universitat Pompeu Fabra, Barcelona -Rheinische Friedrich-Wilhelms-Universität Bonn - London School of Economics - Université catholique de Louvain - Ecole des Hautes Etudes en Sciences Sociales, DELTA, Paris - Ecole de la Statistique et de l' Administration Economique, CREST, Paris - and, as an exchange partner, Tel-Aviv University These institutions organize jointly the activities of the European Doctoral Program in Quantitative Economics, focusing on economic theory, mathematical economics, decision and game theory, econometric theory and methodology, empirical econometrics, and applied mathematical economics. Their aim is to foster exchange of doctoral students between European universities and to promote their scientific interactions. The doctoral training of the above institutions comprises a preliminary year for completing a MA degree or equivalent, an advanced year for completing a MPhil degree or equivalent and, normally, two thesis years to write a dissertation. The coordinated activities of the network create the opportunity for doctoral students to specialize in a large spectrum of quantitative economics areas and to benefit from the diversity of traditions and current research of the partners. An annual jamboree gathers all students. The EDP network offers Marie Curie Training Site Fellowships to doctoral students wishing to stay at a partner university for three to ten months during the advanced year of their course work or for part of their dissertation work. Any highly qualified students already enrolled in a doctoral degree course is welcome to apply for these fellowships. Applications accompanied by two recommendation letters should be sent to the EDP Office of the network institution where
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '“Establishing services enhancing the innovation management capacity of SME's in the Enterprise Europe Network”' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Topic = Establishing services “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network : 2 distinct types of activities are envisaged, which shall be provided as comprehensive seven day service packages following very specific processes. These high added value services will be delivered by suitably qualified senior innovation experts.  WP1 : « Key Account Management » for the beneficiaries of the SME instrument » = the role of the EEN Key Account Manager will be to facilitate the implementation of the SME Instrument in Bretagne and Pays de la Loire, in Phase I and II.WP2 : « Enhancing SME Innovation management capacity” for SMEs independly from a specific project"" =  the aim of this WP is to improve the innovation management capacity of SMEs with high development potential.""


**Keywords:** SME Instrument, KAM, Enhancing innovation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '3DBattery µBattery innovative thin-film flexible Lithium-Ion battery manufacturing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

There is a rapid rise of smart consumer wearable devices in recent years, from go-pros to smart watches and the burgeoning field of Augmented Reality (AR) eyewear. These new and emerging industries require batteries that are increasingly thin, lightweight, flexibly-shaped, and bendable to fit existing and future smart electronics –e.g. fitting within the wrist band of a smartwatch, or the rims of smart glasses. As a result, most require strict size volumes of below 1cm3 to fit these smaller-sized wearable gadgets. Existing smaller batteries that are flexible, do not have the energy and power densities required for sustained high performance. Many leading solutions only have energy densities of below 150Wh/L, a far cry from the ideal >240Wh/L density needed for sustained smart functionality usage. For example, the Google Glass was widely lambasted for its poor battery life, despite an official estimate battery life lasting “one day of typical use”, but rarely lasting 30 minutes when video recording. In order to power these new generation of devices, high capacity, longer duration batteries, in a variety of shapes and sizes become instrumental. 3DB’s innovative technology and materials can create smaller lithium-ion (Li-ion) batteries with higher power and energy densities, which are flexible mechanically and can be easily manufactured in a range of shapes and sizes. 3DB will enable longer battery life, ensuring device manufacturers premium batteries, which bend with, fit precisely, and sufficiently power smart wearable devices. For example, an Apple smartwatch lasting up to a week compared to current battery life of a matter of hours, and a Google Glass that lasts as much as an 8 hour video recording. 3DB’s advanced manufacturing technology will allow battery manufacture