RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'THE VIA EGNATIA: THE ARCHAEOLOGY OF A EUROPEAN CULTURAL ROUTE' under Seventh Framework.

assistant: **Concept**

The aim of this Fellowship is to reconstruct for the first time the late medieval and early modern Via Egnatia, one of Europe’s most important cultural routes. Originally constructed by the Romans, the Via Egnatia linked the Bosporus (and hence Asia) to the Adriatic Sea (and hence Italy and western Europe). The application of multidisciplinary research and cutting-edge technologies will focus on a historical period, which has never been studied systematically. The project aims to develop our knowledge of the key role the Via Egnatia played in drawing together communities, cultures and commodities at a time of political fragmentation and transition from the Byzantine to the Ottoman Empire as the dominant power in southeastern Europe. The project will identify changes in the course of the road by applying traditional and new methodologies. The Fellow, Dr Eurydice Georganteli, will combine her already high degree of knowledge of the archaeological and written evidence with high-tech methods of geographical and environmental science and digital mapping, developed concurrently at Harvard University and the University of Birmingham. The Fellow will benefit from the outstanding research resources in the fields of geography, history, and Byzantine and Ottoman studies at Harvard University. She will be profitably trained in GIS technologies and digital mapping by contributing to the Harvard Digital Atlas of Ancient and Medieval Civilizations. The training at Harvard should enable Dr Georganteli to become an established and well-recognized researcher in the EU. The project contributes to the European Research Area by developing a collaboration between a high-level US and a European university and by promoting links among the research communities in Albania, FY Republic of Macedon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Hybrid Materials for Artificial Photosynthesis', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

HyMAP aims to develop a new generation of multifunctional hybrid photocatalysts and solar photoreactor which would allow the exploitation of at least the 1 % of the sunlight energy for the CO2 photoreduction using water as electron donor. This will imply a CO2 conversion in the range of 12 to 35 Ton/y•ha, depending on product distribution, which represents at least a 20-fold improvement over the state of the art. To achieve this goal, I propose an interdisciplinary research program through which several breakthroughs at different scales will be achieved:Development of efficient multifunctional organic/inorganic semiconductors and metal-organic frameworks photocatalysts with separated reduction/oxidation active sites. The fact of having independent multiple redox sites combined in a single material would maximize charge separation and transport processes, as well as sunlight harvesting.Characterization and modelling of the structural and opto-electronic properties of the proposed materials.Evaluation of the materials in artificial photosynthesis devices. At this stage, a solar photoreactor that would allow good transmission, uniform light distribution and maximize the energy harvesting in the overall spectra will be developed.HYMAP will provide me with an excellent opportunity to lead a consolidated research group. During my scientific career I have demonstrated creative thinking, autonomy and an excellent capacity to carry out state of the art research in heterogeneous catalysis, characterization, modelling and reactor engineering. I have a meritorious research track reflected by a good number of scientific publications, broad professional expertise, innovative project conception and a consolidate network of international collaboration. This, along with my leadership an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Unravelling bacterial immunity against predatory bacteria: the last line of defence'.

assistant: **Concept**

In times of rising antimicrobial resistance (AMR), natural predators of bacteria have great potential as alternatives. However, as with antibiotics, their efficacy is modulated by the ability of bacterial targets to develop resistance. For bacterial predators this relates specifically to understanding predator-prey interactions and particularly prey defence to attack and early stages of infection. However, in stark contrast to phage defence systems, little is known about bacterial prey resistance to predatory bacteria, and barely anything about prey bacterial immunity against predatory bacteria which is the last line of prey defence in the periplasm or cytosol.While the factors determining bacterial immunity against predatory bacteria are unknown, recently I have detected, for the first time, novel evolutionary hotspots in the bacterial prey genome in response to predatory pressure. This reveals unexplored opportunities to elucidate mechanistically bacterial immunity against predatory bacteria. The goal of BAC-MUNITY is to define the systems generating bacterial immunity against predatory bacteria. Appling methods from genetic engineering, protein interaction and various microscopy techniques (time-lapse widefield, super-resolution), we will (i) identify the mechanisms of bacterial prey immune systems against predatory bacteria, and (ii) determine specificity in relation to different predatory bacteria and elucidate how universal they are amongst different bacterial prey. Further, we will (iii) investigate regulation using predators engineered to overcome prey immunity and prey with genetically inactivated self-protection.Unravelling new bacterial immune systems against predatory bacteria will open new research avenues with great potential in biotechnology, while provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modelling sister chromatids cohesion' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The proposed project aims at modeling the structure and mechanisms of sister chromatids cohesion, and how it coordinates with intra-chromatid organization to shape replicated human chromosomes and support fundamental biological mechanisms. Indeed, sister chromatids organisation and its contribution to cellular functions remained elusive due to the lack of appropriate techniques able to distinguish the identical sequences of sister chromatids. The recent development of sister-chromatid-sensitive Hi-C (scsHi-C) technique by Gerlich's group at the host institution enables, for the first time, genome-wide analysis of sister chromatids interactions. These data now require theoretical models based on general physical principles to understand the complex scsHi-C contact patterns and the mechanisms underlying the formation and maintenance of sister chromatids cohesion. I will use coarse-grained polymer simulations and analytical calculations to: (i) unravel the structural and statistical features of sister chromatids organisation, e.g. how cohesive linkages distribute on the genome and the relative impact on sister chromatids conformation and alignment; (ii) understand the interplay of cohesion with dynamic intra-chromatid loops and TADs formation; (iii) predict outcomes of system perturbations on chromosome conformations and functional implications in processes such as gene expression, mitotic chromosome organisation, and DNA repair. Because the topology of sister chromatids is uncharted territory, whatever new knowledge is gained by the modeling approach proposed in this highly innovative study will constitute important contributions to long-standing open questions in the field, and will outline pathways towards new directions to pursue in future research. Given the relevance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modelling and Measurement of Thermal Phenomena in Metal Cutting' (MoMenT) targeting Horizon 2020.

assistant: **Abstract**

The MoMent-project aims to develop a reliable instrument for quantitative evaluation of thermal phenomena in metal cutting, extending an original scientific approach already developed by the Experienced Researcher, which will advance both the fundamental knowledge in this field and the application side of cutting tool products and respective R&D solutions. This approach is based on a coupled measurement and modelling algorithm where cutting temperature and related phenomena are reconstructed by solving an inverse problem of thermal physics. A layered architecture is developed where the parental framework model is strengthened by dedicated satellite modules covering every aspect of heat balance in tooling. The advanced algorithms are supported by experimental setups to convert the research modules into innovative solutions with direct application in the R&D practice of the host: SECO Tools – global market-leading manufacturer of tools and tooling systems for advanced industrial metal cutting applications. To enable the intended innovations, access to and use of world class facilities during 2 secondments at Lund University are foreseen.MoMenT has two workpackages: WP1 is focusing on the development of sensors for off-line and real time measurement of temperature and temperature distribution in a cutting tool. These outcomes have high potential for commercialization by SECO Tools as products for its customers. WP2 is focusing on development of modules designed to support R&D actions related to material and coating development and to solutions for the efficient choice and use of machining coolants. This will contribute to SECO Tools’ “secret know-how” and hence provide a competitive edge.With MoMenT, I hope to develop from a stand-alone researcher that is destined to join
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Balancing Act: Understanding metabolic regulation via the acetyltransferase MOF during Drosophila embryogenesis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The risk of prenatal onset of metabolic disorders is influenced by the maternal environment, which is inherited by the offspring through epigenetic modifications. Epigenetic modifications utilize metabolic substrates, highlighting the connection between epigenetics and metabolism. In Drosophila, one key epigenetic modification is the MOF-mediated acetylation of histone H4 at lysine 16 (H4K16ac), which is known to be intergenerationally transmitted from mother to embryo. This makes Drosophila an ideal model to study how maternally contributed epigenetic modifications and metabolites shape embryonic development.MOF operates in two modes: maternal pools establish chromatin accessibility, while zygotic pools facilitate future gene activation. Given that embryonic metabolism is temporally coordinated during development, the role of epigenetic regulation in embryonic metabolism remains unexplored. To address this, I plan to investigate the temporal contributions of MOF in metabolic regulation during Drosophila embryogenesis.  Specifically, the following aims will be undertaken:Aim 1: Understand the maternal contributions of MOF-mediated metabolic regulation. Aim 2: Investigate the zygotic contributions of MOF in metabolic regulation. Aim 3: Uncover the association of MOF with the MSL or NSL complex to provide a mechanistic basis for metabolic regulation.These aims will be achieved through a combination of cutting-edge techniques involving metabolomics, RNA-sequencing, and epigenomics. This research will provide insights into metabolic regulation during early development and its implications for maternal impacts on offspring metabolism. The findings will enhance our understanding of the fundamental mechanisms underlying the epigenetic basis of metabolic regulation, with broade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ROLE OF THE TANYCYTIC BARRIER AT THE BLOOD-HYPOTHALAMUS INTERFACE DURING METABOLIC DISORDER DEVELOPMENT' in the context of a Horizon 2020 call.

assistant: **Objectives**

Metabolic disorders such as obesity and diabetes are age-related diseases, and lead cause of death in Europe. Adiposity signals such as leptin and insulin, whose circulating levels are in proportion to body fat, convey metabolic information to neural networks that regulate energy homeostasis in the hypothalamus. In leptin-deficient humans and mice, leptin administration effectively reduces hyperphagia and obesity. Paradoxically, most cases of obesity display high circulating leptin levels that fail to reduce appetite or increase energy expenditure. This raises the possibility that leptin transport across the blood-brain barrier to the cerebrospinal fluid (CSF) or to its sites of action within the hypothalamus is a limiting step defective in obese patients. The host laboratory recently demonstrated that tanycytes, a hypothalamic glia lining the floor of the third ventricle, were responsible for shuttling leptin from the periphery to the CSF and that such conduit was blunted in mice with diet-induced obesity. Leptin transport by tanycytes could thus play a critical role in the pathophysiology of leptin resistance. The overall objective of this project is to further elucidate whether the alteration of the adiposity signals transport into the metabolic brain across hypothalamic barriers is the main cause of the onset of obesity. To this end, a combination of in vitro and in vivo approaches, using genetically modified mice and pre-clinical models of obesity, will be implemented in order to elucidate the molecular mechanisms for the transport of blood-borne leptin into the CSF by tanycytes. It is anticipated that implementation of this project will expand our knowledge of the mechanism underlying human obesity and hold therapeutic potential for treating it. Besides, the propo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pre-Commercial Procurement of Future autonomous bus urban level Operation Systems' in the context of a Horizon 2020 call.

assistant: **Objectives**

The FABULOS PCP focuses on how the cities can use autonomous buses in a systemic way.Cities, such as Helsinki, already have a relatively integrated public transportation system,although not capable of absorbing or utilizing RTI in a systemic way for smart routing and such.Pre-Commercial Procurement (PCP) of  Operation of an autonomous minibus service, for a specific line/zone in urban environment.Leading European Smart Cities have been running some of the world's first autonomous buses on open streets.The FABULOS PCP goal is to push the market to creation of smart systems for the management of autonomous electric bus fleet operations and related services, in urban environmentsThis sort of intelligent transportation systems and integrated transportation approaches, are key to enable a sustainable development of public transportation and for cities to be able to become car free in a foreseeable future.Autonomous buses are a key part of this future. The robotic bus technology is fast approaching its market readiness stage; however current transportation systems are not equipped to deal with such type of transportation.The management of autonomous fleet as part of public transport is missing. Also some parts of the driving automation need to mature.The PCP should now focus on how the cities can use autonomous buses in a systemic way. Cities, such as Helsinki, already have a relatively integrated public transportation system, although not capable of absorbing or utilizing RTI in a systemic way for smart routing and such.In order to capitalize on the potential of autonomous buses, Cities should combine efforts in pushing the market to develop system solutions capable of bridging autonomous bus technologies and the cities public transportation systems, helping them to become s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Laser-induced Terahertz Spin Current Nanoscopy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

TeraSCN will establish spintronic terahertz emission nanoscopy (STEN), the first European tabletop platform capable of imaging spin current dynamics with nanometer spatial and femtosecond temporal resolution, the natural time and length scales of spintronic processes. This development is achieved by combining spintronic terahertz emission spectroscopy with scattering-type scanning near-field optical microscopy (s-SNOM). I will adapt and optimize a commercial s-SNOM for STEN operation and determine its instrument response function, enabling extraction of spin current dynamics from measured terahertz signals. Unlike synchrotron-based X-ray techniques (e.g., XMCD-PEEM), STEN provides superior spatiotemporal access at much lower cost and with year-round availability, ensuring broad adoption across European laboratories.With this capability, TeraSCN will address fundamental open questions in spintronics. I will resolve spin-current dynamics at domain walls, defects, and pinning sites to identify their transport mechanisms (ballistic, diffusive, tunneling). I will also image light-induced terahertz spin currents in magnetic skyrmions at previously inaccessible resolution, probing spin and magnon relaxation and experimentally testing the predicted skyrmion topological terahertz resonance. These experiments will deliver the first direct movies of spin-current dynamics at their natural scales.TeraSCN will have both scientific and technological impact. Scientifically, it will provide a powerful tool for uncovering fundamental spin physics. Technologically, by elucidating how defects and nanoscale textures govern spin-current efficiency, STEN will accelerate the development of next-generation spintronic technologies, including racetrack memories, spin-based logic, and neuromorphic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Coordination of European Transnational Research in Organic Food and Farming Systems' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Organic agriculture and food markets have grown considerably and organic agriculture addresses important challenges of European agriculture, such as sustainable production of high quality food, reducing dependency on high energy inputs, improving environmental and nature conservation, climate change adaptation, animal welfare and rural livelihoods. Organic farming and food systems still have a big potential for innovation and improved solutions. Research activities will be important for this. Coordinated transnational research has the potential to create a less fragmented research area in this fast growing sector. CORE Organic II builds on the outcome of the first CORE Organic to aim at an effective and sustainable transnational research programme. It will identify common research priorities for the organic sector where a transnational approach will give added value, launch at least two transnational calls, initiate research projects, organize project monitoring and dissemination of results, and consider funding models. CORE Organic II will also develop all components to continue the transnational research activities beyond the ERA-NET. The results of CORE Organic II will be a strong and sustainable network of funding bodies, all components for the effective continuation of collaboration, a series of on-going research projects and a plan to support dissemination. The expected benefits for Europe will be to reinforce its leading status and excellence in organic research, enhance the European research area on organic agriculture, increase the efficiency in use of organic research funds and improve the impact of research on the organic sector’s development. Initiating projects on topics identified as common priorities will allow the sector to better meet the demand for org