RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Personalised Prognostic Models to Improve Well-being and Return to Work After Neck and Low Back Pain' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Neck and low back pain (NLBP) are leading causes for years lived with disability in Europe and worldwide. About 70% of all adults experience NLBP at some point in their lives, and both conditions are among the top ten in terms of overall disease burden expressed as disability adjusted life years. Management of NLBP is a difficult challenge for healthcare professionals since their decisions have a decisive impact on the patient’s future health and welfare, as well as on the economic burden on the public and private healthcare systems. However, health professionals often lack appropriate information to tailor the management and follow-up of individual patients and to predict the outcome of a certain treatment. At European level, diverse research initiatives are undergoing at this moment for tackling NLBP from diverse angles, including biomarkers (PainOmics), pain self-management (selfBACK), lifestyle and workplace conditions (AHA), or patients stratification (STarT Back). Back-UP project provides a wider vision of NLBP, bringing together the research groups that are leading these and other innovative approaches to create a prognostic model to underpin more effective and efficient management of NLBP based on the digital representation of multidimensional clinical information and on simulations of the outcomes of possible interventions. Patient-specific models will provide a personalised evaluation of the patient case, using multidimensional health data from the following sources: personal, health, psychological, behavioural, and socioeconomic factors related to NLBP; biological patient characteristics, including musculoskeletal structures and function, and molecular data; and workplace and lifestyle risk factors. Back-UP will provide health, well-being and economic benefit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'An online software platform for effectively matching investors with start-ups, focused on boosting the cleantech sector' under Horizon 2020.

assistant: **Concept**

CAGIX is a software company, with long-term experience in the start-ups, incubation and investment industry, which has developed an online incubation platform that covers investment preparation, incubator operations and portfolio company management. The investor ecosystem is fragmented and opaque and attracting investment is a lengthy process. Early stage start-ups often have little knowledge of business planning or fund-raising procedures and therefore deals can be perceived as risky. Currently, there is no system on which investors can search for valuable start-up industries abroad. Start-ups and innovation need to be better managed through technology to achieve results; technology has the potential to make incubation, investment preparation and capital transactions more efficient, highly scalable and less expensive. CAGIX’s software platform offers start-ups a proven efficient path to build up the perfect investor package and provide the relevant information needed by investors. This facilitates the due diligence of interested investors, saving time and expenses and guaranteeing a high quality standard and uniformity for the deals. The CAGIX platform hosts an innovative proprietary deal search engine which when applied to the start-up database enables investors to meet companies raising money and carry out faster transactions through CAGIX’s streamlined process. The platform is specifically focused on CLEAN-TECH and climate change hosting eighteen diverse sectors within the field including biofuels, hydropower, recycling and transportation. Within the overall project, CAGIX aims to: standardize the design of the website and information portrayed to investors; localize the platform to support foreign currencies and languages; address local financial laws/regulations f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional roles of long noncoding RNAs in drought stress responses of Arabidopsis' (GreenLincs).

assistant: **Concept**

In the coming decade declining water availability will exert increasing pressure on crop productivity worldwide. One of the solutions is to breed crop plants with enhanced drought tolerance.  Whilst plant breeders are continuing to make progress in this direction, elucidation of the molecular basis of drought stress will help not only traditional breeding efforts but also formulate new transgenic strategies to produce plants with enhanced adaptability under conditions of water limitation.The traditional view that protein coding genes are the only regulatory elements in the genome has been challenged by the discovery of miRNA genes and more recently by the discovery of transcription units producing long intergenic non-coding (linc)RNAs. Recent work in yeast and mammals indicate that these lincRNAs play important roles in cell differentiation, organ development and responses to stress. Still, very little is known about plant lincRNAs.In this proposal we will use the model dicot plant, Arabidopsis, to investigate several novel molecular aspects of drought stress while providing the applicant advanced training in scientific and complementary skills to substantially enhance career development. We will first identify and characterize in detail lincRNAs whose expression levels are changed in response to drought. Preliminary results from Prof. Nam-Hai Chua’s lab (outgoing host) have uncovered more than a few hundred lincRNA genes that belong to this category and whose functions await discovery. This is a potential class of genes that may orchestrate drought responses by the epigenetic regulation of gene expression. Manipulation of the expression levels of these candidate lincRNAs will uncover their possible functions and analysis of chromatin modifications and neighboring gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TRafficking as A Criminal Enterprise' (TRACE).

assistant: **Concept**

TRafficking as A Criminal Enterprise (TRACE) aims to support stakeholders in combating and disrupting human trafficking, one of the largest criminal enterprises in the world, by assessing and consolidating information surrounding the perpetrators and the wider trafficking enterprise. TRACE adopts a multi-disciplinary approach: legal, criminological, socio-economical, psychological and law enforcement-oriented, in order to provide a full account of the phenomenon, and build upon on-going European and national projects and activities. It will focus on the activities of the perpetrators by developing an understanding of the structure, social relationships, modus operandi, travel routes and technologies associated with different types of human trafficking (human trafficking for sexual exploitation, labour exploitation, forced criminal activities etc.). Based on the analysis of perpetrators’ behaviour TRACE seeks to be able to better identify who is in danger of being trafficked and furthermore, who is vulnerable to becoming involved in human trafficking (including those who may have been victims themselves). TRACE acknowledges that human trafficking involves a chain of criminal behaviours, activities and processes and will consolidate up-to-date information, good practice and expert opinion to provide stakeholders with an intervention strategy based on policy recommendations for  disrupting the trafficking chain. These recommendations will be based on stakeholder consensus reached via interviews, expert workshops, and the final conference. TRACE has designed its dissemination plan, including the development of briefing papers, to disseminate relevant up-to-date information surrounding the different facets of the project to relevant stakeholders in order to support their eff
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nano Engineering for Cross Tolerance: new approach for bioengineered, vascularised, chimeric islet transplantation in non-immunosuppressed hosts', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Diabetes is caused by insufficient or lack of insulin secretion by the specialized B cells of the pancreas and, if not treated adequately evolves into in complications which alter patients integrity and wellness. Treatment is based on lifetime drugs administration for blood glucose control or parenteral infusion of insulin to better control glucose levels and glycosylation of hemoglobin. Artificial pancreases are in development but still dependent by external energy sources and need permanent transcutaneous access to release the hormone. Pancreatic whole organ transplantation is a major intervention requiring selected recipient and matched cadaveric donor which keep numbers down. Islet of Langerhans transplantation is a non-invasive method for the treatment of type 1 diabetes but several questions remain and several issues have to be addressed in order to improve the method since islet engraftment is clearly suboptimal, as a result of pro-apoptotic and pro-inflammatory stimuli sustained during islet isolation and at the site of implantation, the long-term islet graft function drops to 15% with time, and the current systemic immunosuppressive regimen has several drawbacks in terms of side effects. Solution should be find to increase transplantation efficiency with an higher number of islet, eventually from animals, induce tolerance toward the graft, avoiding systemic, lifetime immunosuppression and, lowering a specific inflammatory reaction and enhancing graft micro vasculogenesis to improve islet nesting. NEXT provides a 360° solution to the pitfalls of current methodology for pancreatic islet transplantation: i) Nano technologies, to engineer donor cell surfaces in order to derange recognition and suppress their rejection; ii) Advanced tissue engineering methods, to as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The Telosome: Deciphering the architecture of the shelterin complex and its network'.

assistant: **Concept**

Telomeres of eukaryotic chromosomes are protected by the shelterin complex. The human shelterin is a six-subunit protein assembly (TRF1, TRF2, TPP1, POT1, TIN2, Rap1). This complex associates with telomeric DNA and prevents the mistaken detection of the telomeres as double strand breaks by the DNA Damage Response (DDR) machinery. Illicit DNA repair at telomeres results in cell cycle arrest and end-to-end chromosomal fusions or other improper recombinations causing genome instability. The abrogation of the shelterin assembly or subunit removal decompacts the telomere and causes DDR accumulation. Defects in the shelterin complex are associated with telomere-related pathologies such as cancer and aging. The supra-structure of the mammalian shelterin complex remains unknown. Therefore, we lack fundamental knowledge regarding its organization and function.The shelterin complex also acts as a signalling hub, recruiting accessory factors that participate in telomere homeostasis and maintenance; and shelterin subunits are subjected to posttranslational modifications (i.e., ubiquitination, phosphorylation, SUMOylation); however, the functional role of these modifications is not fully understood. The overarching aim of this project is to solve the atomic structure of the human shelterin complex by cryo-EM and elucidate the molecular events of telomere biology during the cell cycle combining cellular and proteomic approaches. The outcomes will provide the first structure of the shelterin complex and the shelterin interactome, which will allow to understand defects underlying pathology at molecular level and join this information to physiologic and phenotypic data. This project will have a substantial impact on my career, as new skills in biophysics, structural biology and proteomi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Psychiatric spaces in transition: discourse, dwelling, doing' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

To ask searching questions about changes in the treatment of people with mental health problems - about the extent to which they experience the right mix of 'protective' and 'empowering' support - is to probe deeply into the 'humanity' of European society. Responding to this challenge, the proposed action will combine in-depth investigation into the near-unique 'laboratory' of psychiatric transition offered by one site in Scotland, Gartnavel Royal Hospital, Glasgow, with an explicitly comparative framing derived from research on equivalent shifts occurring in Sweden. A multi-disciplinary research team, working across human geography, planning-architecture and clinical psychiatry, will deploy a range of engaged, qualitative research methods: interviewing, focus groups, walking tours, drawing work and directed photography, coupled to both standard and more experimental techniques for 'data' interpretation. Based on this research, the team will develop conceptual resources for a 'model' of European psychiatric transition, notably from institutional (asylum/hospital) to de-institutional or trans-institutional landscapes of mental health care. More empirically, the objective is to recover subjective experiences of the changing spaces of Gartnavel as felt, understood and represented by different cohorts of patients and staff (past and present), gathering these materials into a 'living archive' - available on-line and via an exhibition/event - to be made available to all connected with the site, local residents neighbouring the site and a wider public concerned with mental health matters. Through both this impact work and scholarly outputs, a further objective is critically to appraise psychiatric transition, and in particular to re-evaluate the notion of 'the asylum' in an er
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Semi-supervised Structured Output Learning from Partially Labeled Data'.

assistant: **Concept**

Learning classifiers automatically from examples is subject to themultidisciplinary field of machine learning.The structured output learning (SOL) is concerned with thelearning of classifiers for prediction of multipleinterdependent variables exhibiting some structure dependence.Recent progress in SOL focuses mainly on supervised methodsthat require labeled examples. A high cost of labeled examplessignificantly limits application of SOL to many domains.Our goal is threefold. First, to developed framework for semi-supervised SOL from cheap partially labeled examples. Second, to apply this new framework to two important SOL tasks: (i) Markov Networks learning and (ii) learning of 2-dimensional image grammars. Third, to use the new algorithms for solving computer vision problems including the image segmentation and the car license plate recognition.To achieve the first goal, we will examine two strategies. First, we willcombine powerful discriminative methods for SOL with generative models offering a principled way to deal with missing labels. Second, we will extend the existing semi-supervised methods in order to handle the partially labeled examples.To achieve the second goal, we will incorporate the existing methods forsupervised SOL of Markov Networks and 2D grammars to the frameworkdeveloped as the first goal.To achieve the third goal, we will build on the technology forimage segmentation and license plate recognition developed bythe host. The currently used classification methods will bereplaced by the developed semi-supervised SOL algorithms todemonstrate their effectiveness on real-life problems.Achieving the goals will be possible by joining the expertiseof the applicant and the host. This applies both to theoreticaland application oriented goals. The applicant is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Maintenance and Improvement of component-based applications diffused in ASP mode' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

MECASP is a development environment oriented towards maintenance, adaptation and follow-up of applications upgrades, aiming by means of the appropriate tools to reduce corresponding work loads. It enables these composite applications to be diffused more easily in ASP mode. Based on an open metamodel and using new technologies (XML), the project creates a universal development framework for the integration of existing and future tools and applications. It adds original automated merging tools when the components are upgraded in multiple directions. MECASP addresses professional developers and end users, whom it offers the possibility of creating new services intended for small and medium-sized groups (professional services, groupware and personal applications) and of obtaining productivity gains for different purposes: costs, diffusion, reactivity, access.Objectives:The main objectives of MECASP are as follows:a) to supply a tool integration environment oriented towards the adaptation of applications,b) to make that environment universal and open,c) to provide benefits of specific developments to each user,d) to promote the development of rented applications (in ASP mode),e) to enable the development of applications and services for small groups of users,f) to promote large-scale personalisation,g) to facilitate the management of upgrades and adaptation of applications and to automate merger tasks,h) to facilitate the deployment of applications (installation and configuration),i) to achieve productivity gains (costs, deadlines and functionalities) on adaptations of applications,j) to free the suppliers of applications from specific" management constraints.Work description:MECASP is an open and extensible environment dedicated to the adaptation of applications. MECASP is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'breAkThrough innovaTion pRogrAmme for a pan-European Detection and Imaging eCosysTem' under Horizon 2020.

assistant: **Concept**

The ATTRACT Phase-1 project proposes a new collaboration paradigm aligned with the ‘Open Science, Open Innovation and Open to the World’ philosophy. Its objective is the identification and initial development of breakthrough detection and imaging technology concepts for expanding fundamental research frontiers and suitable for future industrial upscaling for novel applications and business. It promotes the involvement of national and pan-European Research Infrastructures and their associated research communities, industrial organizations (especially SMEs) and innovation and business specialists. It proposes a co-innovation approach in which scientific and industrial communities jointly pursue and generate breakthrough concepts in close and equal partnership. The project implementation starts with the launch of an Open Call by the project consortium for €17 million of financial support to Third-Parties. The proposals received will be peer-reviewed by an Independent R&D&I Committee of top experts in the field of detection and imaging technologies. After this process 170 breakthrough technology concepts will receive €100,000 of seed funding each (“lump sum”) to develop the concepts further during one year. The funded projects will then present their results in a Final Assessment Conference in Brussels. The ATTRACT Phase-1 consortium members will provide business assessments to the funded project teams to enhance awareness of future commercial applications. Furthermore, two pilots based on design thinking methodologies will be run for/with interdisciplinary master level students, aimed at discovering and generating social value applications inspired by the technologies of the funded projects. The ATTRACT Phase-1 project consortium comprises top partners capable of catalysin