RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Study of regulation of e2f activity by the co-activator cbp' under Fourth Framework.

assistant: **Concept**

Considerable evidence suggests that the E2F transcription factor family play a critical role in cell growth control. Study of E2F1 protein, a major component of E2F has shown that its activation domain could be repressed by direct binding of the retinoblastoma protein and activated by binding of the proteins MDM2 and CBP to this same domain. The same region of the activation domain of E2F1 is bound by RB and CBP, which display antagonistic effect on E2F1 activity. The aim of this project will be to establish the relationship between RB and CBP interaction at the E2F1 activation domain. This will include a biochemical analysis in order to characterize the mechanism of RB and CBP binding to the E2F1 activation domain. It will also include a biological analysis, in order to establish whether CBP, through the activation of E2F1, can overcome the RB-induced G1 arrest, induce S-phase progression or display oncogenic activity in cooperation with an activated ras oncogene.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Application of molecular genetic advances to the understanding and management of hypertrophic cardiomyopathy', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives:The objectives of the program are:1.To organise a multicenter program of genotyping in HCM.2.To further examine the relation between genotype and phenotype in HCM.3.To perform in vitro and in vivo investigation of the functional consequences of mutations in the HCM disease-genes.4.To assess the role of genotyping in risk stratification for sudden deathBrief description:This Reinforced Concertation will bring together and co-ordinate European research into the molecular genetic basis and clinical expression of familial hypertrophic cardiomyopathy, an autosomal dominant heart muscle disorder which is caused by mutations in sarcomeric contractile protein genes. The program of combined clinical and molecular genetics will:* organise a shared multicenter program of genotyping in HCM with specific laboratories responsible for particular genes* obtain a sizeable population of clinically well characterised and genotyped HCM patients in order to examine the genotype/phenotype relation. Aspects of the phenotype to be examined include: cardiac morphology and histology and determinants of prognosis/sudden death. The influence of modifier genes on the extent and severity of left ventricular hypertrophy will be examined.* assess the functional consequences of mutations in HCM disease genes through the development of transgenic animals* assess the potential impact of a genetic diagnosis on the identification and management of patients at high risk of sudden deathIt is anticipated that achievement of these objectives will:* facilitate diagnosis and management of patients with HCM who are at particular risk of sudden cardiac death* provide scientific insight into the determinants and functional development of myocardial disarray and hypertrophy in HCM and the hypertrophic pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Regulation of DNA replication by the E2F/RB pathway in Arabidopsis' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In plants and animals the E2F-RB pathway is one the most important cellular mechanisms that control the decision to continue or stop cell division. E2Fs are a family of proteins that require the association with the DP proteins for control the transcription of genes involved in cell cycle transitions and DNA synthesis, e.g., components of the pre-replication complexes (pre-RC), among others. The function of these E2F/DP factors is negatively regulated by the retinoblastoma protein (RB), which binds to E2F proteins and block their trans-activating potential. Arabidopsis, has six E2Fs (E2Fa through E2Ff) and 2DPs (DPa and DPb) genes. Two of them, E2Fa and E2Fc have been analysed in more detail: E2Fa acts as a transcriptional activator while E2Fc as a repressor.Recent studies in Drosophila and mammalian cells have revealed a novel function of the E2F/RB pathway. This is its involvement in regulating directly the activity of DNA replication origins. Thus, a RB-mediated association between the E2F/RB complex and certain O RC proteins has been observed. The E2F-RB-ORC complex seems to limit DNA replication by inhibiting the activation of DNA replication origins.The present project is specifically aimed at elucidating the potential implications of the plant E2F/RB pathway in regulating ORC function and, eventually, DNA replication origin activity. To this end, we will use Arabidopsis as a model system. In a first step, we will generate a full interaction map of all six Arabidopsis E2Fs with each Arabidopsis ORC subunit using a yeast two-hybrid approach; we will confirm positive interaction by in vitro pull-down experiments using purified fusion proteins expressed in bacteria. The receiving laboratory has generated a number of transgenic plants expressing tagged versions of pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Studies on the nucleation of zeolites from gels containing pre-structured Si species' in the context of a Sixth Framework call.

assistant: **Objectives**

Understanding of the nucleation of zeolites continues to be one of the main targets in its chemistry. In spite of the huge effort done by scientific community in this field and the high number of the characterization techniques used, the information relate d to the nature of the species involved in the nucleation is generally scarce, which is the main limitation for advancing in the knowledge of crystallization processes. We propose a study trying to overcome this disadvantage, that is, using a priori knowing the Si species that will cause the crystallization. Those are called pre-structured species since they contain some of the subunits that will be present in the final crystalline phase. Starting from gels containing these well-known species that can poten tially act as nuclei in the formation of a particular zeolite, it would be relatively easy to follow the crystallization processes. In particular, for systems in which some evidences on the growing have been clear in the literature, we will start from the linear or layered species that joining together generate the final tri-dimensional structure. In this sense, the case of MCM-22 zeolite could be an adequate system to be studied as starting point. A proper characterization following the crystallization wou ld be as important, if no more, as synthesis itself in the development of this project. Consequently, a systematic characterization by both in-situ and ex-situ techniques is planned. Thus, in-situ synchrotron-radiation techniques such as combined small and wide-angle X-ray scattering (SAXS/WAXS) and energy-dispersive X-ray diffraction (EDXRD), can give us essential information on the first stages of the nucleation and kinetics of crystallization, respectively; ex-situ 27Al and 29Si solid and liquid NMR woul d al
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Molecular Spectra of Missing Ions in the Laboratory and in Space'.

assistant: **Concept**

Ions play a key role in the chemical evolution of our universe. The process of star and planet formation istightly connected to the presence and abundance of these species. Their spectra turn into diagnostic tools forvarious astrophysical environments and their temporal evolution. However, laboratory spectra of most ionsrelevant to astrophysics are not available. Moreover, predicted spectra from ab-initio theory are not nearlyaccurate enough to guide astrophysical searches. Therefore, corner stones for our understanding of chemistryin the interstellar medium are missing. In sharp contrast, highly sensitive telescopes with large collectionareas are ready to find these species in space.In order to make this important next step in molecular astrophysics I propose to record high-resolutionspectra from the microwave to visible range using our unique and innovative light induced reactions (LIR)methods in ion traps. It is molecule specific through mass selection, many orders of magnitude moresensitive and less complex due to buffer gas cooling as compared to conventional methods.High-resolution spectroscopy is the most accurate discipline in quantitative sciences and for molecules it islinked to highly accurate molecular structures, bond lengths and angles. But this fundamental concept is putinto question for very floppy molecules, e.g. protonated methane, one of the key missing ions in space.Therefore, also new models describing the structure and internal dynamics of molecules shall be developedin this interdisciplinary project.Based on the laboratory spectroscopy in this project new molecules will be found in space. We shall unravelthe role of the most important missing ions which will have great impact on the interpretation ofastrophysical observations. At the same time und
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The malignant Glioma immuno-oncology matchmaker: towards data-driven precision medicine using spatially resolved radio-multiomics'.

assistant: **Innovation**

Adult and paediatric malignant glioma (GBM and pHGG) remain among the most difficult-to-treat cancers with 5-year survival rates of <5% despite intensive standard-of-care therapy. The differences among patients and the heterogeneous and plastic nature of each individual tumour have resulted in all therapeutic clinical trials failing during the past 20 years. Recently, immunotherapy has been showing great promise, but only in subsets of patients. Identifying those patients cannot be done a priori as biomarkers are still largely missing, nor are we able to follow-up on therapeutic efficacy when patients get treated. The GLIOMATCH project aims at improving the clinical outcome of GBM/pHGG patients by enabling immunology-based patient stratification to empower personalised matching of appropriate immunotherapy, while improving follow-up of clinical responses to existing/novel therapeutics. This will be achieved by integrating spatially resolved, multi-layered tissue maps (using integrated single-cell multiomics), with non-invasive MRI images. This integration will fuel into a novel MRI Radio-multiomics hub, that will be made available to clinical professionals through which they can perform tumour-host based patient stratification and personalised therapy matching while interpreting longitudinal follow-up and treatment efficacy. The proposed data-driven models will be developed by analysing the largest cohort of immuno-oncology (I/O) treated GBM/pHGG patients (n>300, including pre-post treatment samples) with matched controls (n>300) and exceptionally long-term surviving GBM patients (n~140), in which various tumour-host niches will be studied in how they respond to I/O perturbations and lead to improved clinical outcome. This will be empowered by deploying an UNCAN-compati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Researching crowdsourcing to extend IoT testbed infrastructure for multidisciplinary experiments, with more end-user interactions, flexibility, scalability, cost efficiency and societal added value' in the context of a Seventh Framework call.

assistant: **Objectives**

IoT Lab is a research project exploring the potential of crowdsourcing to extend IoT testbed infrastructure for multidisciplinary experiments with more end-user interactions. It will research and develop:1. Crowdsourcing mechanisms and tools enabling testbeds to use third parties resources (such as mobile phones), and to interact with distributed users (the crowd). The crowdsourcing enablers will address issues such as privacy by design, identity management, security, reputation mechanisms, and data ownership.2. Virtualization of crowdsourcing and testbed components by using a meta-layer with an open interface, facilitating the integration and interaction with heterogeneous components. It should ease data integration and reduce the cost of deployment in real environment.3. Ubiquitous Interconnection and Cloudification of the testbeds resources. It will research the potential of IPv6 and network virtualization to interconnect heterogeneous and distributed resources through a Virtual IoT Network and will integrate them into the Cloud to provide an on-line platform of crowdsourcing Testbed as a Service (TBaaS) available to the research community.4. End-user and societal value creation by analyzing the potential end-users and crowdsourcing participants to propose an optimized model for end-user adoption and societal value creation.5. Crowdsourcing-driven research" as a new model in which the research can be initiated, guided and assessed by the crowd. It will compare it to other models.6. Economic dimension of crowdsourcing testbed, by analyzing the potential markets and business models able to monetize the provided resources with adequate incentives, in order to optimize the exploitation, costs, profitability and economic sustainability of such testbeds. It will also devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transnational Figurations of Displacement: Connectivity and Mobility as Solutions to Protracted Refugee Situations' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

TRAFIG introduces a novel perspective on protracted displacement situations (PDS) that will improve the protection and resilience of refugees and enhance trust and cooperation between refugees and host communities. It considers the transnational and local connectivity of displaced people and host communities as well as their capability of mobility as socioeconomic and socio-psychological resources that displaced people use and upon which their resilience relies. The project will develop a rapid assessment tool to identify the most vulnerable groups in PDS and to analyse interactions between displaced and host communities. As an evidence-based tool for creating impact, it will support policymakers and practitioners to enhance the self-reliance of displaced people as well as host-refugees relations through tailored programming and policy development. We closely cooperate with key stakeholders throughout the entire life cycle of the project. Our research is based on a novel concept of transnational figurations of displacement that combines the figuration model – a meso-level approach emphasizing the networks of interdependent human beings – with the transnationalism approach and state-of-the-art knowledge on forced displacement. Through comparative empirical research, both qualitative and quantitative, in camps and urban settings at sites in Asia, Africa, and Europe, TRAFIG will answer the following questions:  (1) How do displaced people gain access to and make use of humanitarian and migration policies and programmes?  (2) Why and how do displaced people live in vulnerable situations and sustain their livelihoods? How can policy support their self-reliance? (3) How do transnational networks shape refugees’ experiences and trajectories? (4) Which processes structure relat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Addressing Verification and Validation Challenges in Future Cyber-Physical Systems', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The scientific objective of the ADVANCE project is to conceive new approaches to support the Verification and Validation (V&V) of Cyber-Physical Systems (CPS). It will explore techniques, methods, and tools applicable to different phases of the system lifecycle, but always with the final objective of improving the effectiveness and efficacy of the V&V process. In particular, ADVANCE will focus on two main aspects of V&V: i) techniques to collect V&V evidences for a CPS (focusing on system modeling, testing,  fault forecast, and systematic processes like FMEA), and ii) techniques to manage and analyze data of the system under analysis (focusing on data analysis, requirements management, traceability).The strategic objective of the project is to build an international network of collaborations on the topic of V&V of CPSs. Besides allowing the consortium to reach the project’s scientific objectives, the established interactions would allow the training of students and professionals on the latest innovations in the V&V panorama, and have them work together towards a common goal. In fact, besides the technical challenges described above, an important factor hampering advancements in the V&V of CPSs is a worldwide lack of skilled professionals in V&V, software testing, and Information and Communication Technology (ICT) in general. One of the outputs of the project will be a set of training material, both in the form of slides and video courses, on the topic of Verification & Validation of Cyber-Physical Systems. These objectives will be pursued by joining together V&V experts having different specialization and different backgrounds, and establishing a targeted transfer of knowledge and collaboration program, using two real case studies as reference throughout the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Multi-dimensional omics approach to stratification of patients with low back pain' (PAIN-OMICS) targeting Seventh Framework.

assistant: **Abstract**

Pain-OMICS is a multidisciplinary consortium of leading clinical, academic and SME researchers in pain and different omics technologies. Genome-wide association studies identified a number of loci associated with pain, but the level of knowledge about underlying mechanisms of different pain syndromes as well as individual variation in the disease course remains inadequate. Pain-OMICS will capitalise on its existing high quality clinical, genetic, biochemical and pharmacological data and biological samples on over 5000 well characterised patients with low-back pain (LBP) and controls available to our EU and US clinical partners. We will exploit novel technological approaches made available through the expertise and global leading position of our analytical partners. These comprise cutting edge genomic, epigenomic, glycomic, and activomic approaches which reflect signal transduction and membrane dynamics. We believe that the inclusion of these complementary analyses will elucidate pathways through which acute LBP fails to resolve and becomes chronic LBP. In addition, these approaches will reveal pathways and biomarkers of chronic pain through which individual differences affects symptoms and response to therapy. Participation of leading clinics on both sides of the Atlantic will enable replication of all finding in at least three independent large cohorts, as well as in prospective study and a large twin cohort. A complex systems biology approach will be used to integrate, interrogate and understand this multidimensional dataset in order to achieve the aims of identifying novel diagnostic and prognostic biomarkers as well as new targets for therapeutic intervention. The track record of achievement of our partners coupled to participation of research-intensive SMEs is a st