RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biocontamination survey for Microbially Influenced Corrosion exposure TEST' (MICTEST).

assistant: **Concept**

Microbially influenced corrosion (MIC) is a costly problem caused by microorganism growing in the hydrocarbon-water interphase, affecting fuel production and processing equipment, fuel storage tanks, fuel handling systems and other infrastructure. Anti-microbial and/or antibiofilm materials and coatings are promising solution to passively control bio-contamination by preventing the adherence and growth of species to surrounding surfaces. However, methods for assessing antimicrobial materials under industrially-relevant environments are still missing. Studies defining real bio-contamination and key parameters are fundamental. MICTEST will develop new bio-contamination exposure protocols for lab-scale validation of materials, coatings and components for aircraft fuel systems. MICTEST will be focused on: i) performing an exhaustive sampling of contaminated fuels and materials, ii) defining representative core microbiomes of microorganisms isolated from real samples, iii) determining key parameters mimicking real environments, iv) selecting representatives coatings, materials and components, and v) proposing the most appropriate combination of technologies for assessing antimicrobial/antibiofilm properties correlated with material degradation, coating performance and the potential effects on fuel properties. Different protocols will be developed and adapted to fuel type, material and environmental conditions that are representative of the bio-contamination developed in real scenarios.The added value of the new protocols will be demonstrated by performing validation studies in a list of materials (metallic elements, coatings, polymers) in 25L pilot tanks in climatic chambers for comparing the biofilms obtained following the new methods, current methods and the ones using rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of quick non expensive moulds for preseries of plastic and composite components' under Fourth Framework.

assistant: **Concept**

The project has complied with the original objectives and the deliverables as described before have been supplied. The two final mould inserts that were to be manufactured have been tested successfully. The main technical obstacle lay in the handling of the aluminium composite by means of the lost wax processes, as there was practically no experience known in the world with this material.Sound components have been produced at the end of the project and the outstanding wear properties of the selected material have been confirmed. The results of the project have opened new perspectives for this family of materials that could now accede to new important markets.The main outcomes of the project can be summarised as follows:1) Manufacturing of two prototype mould inserts (For polymer injection and SMC) using rapid prototyping models and the lost wax processes;2) Manufacturing and preparation of Castform models suitable for investment casting applications;3) Economical and technical evaluation report of the new technology including a summary of the knowledge acquired during the project.One of the main industrial problems is the high cost and time required for the development of a new product, being the production of the moulds for the prototypes one of the most lengthily and costly step in the development stage. In the case of the plastic and polymeric composites industry, the molds are usually machined from steel, or eventually from aluminium when a small number of prototypes is sufficient. Modifications are very limited, expensive, and especially time consuming, exceeding periods of six months very often. The aim of the present project is the development of a new manufacturing method for the production of molds for prototypes and small series of components, in a short time
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'HYdrogen cells for AiRborne Usage'.

assistant: **Innovation**

In order to meet the increasing pressure to reduce fuel consumption and greenhouse gas emissions, airlines are seeking alternative sources to power non-propulsive aircraft systems. The next generation of aircraft is heavily investigating the use of non-fossil fuel to generate electrical power for non-essential applications (NEA). Hydrogen fuel cells are actively being pursued as the most promising means of providing this power. Fuel cells also have the added benefits of no pollution, better efficiency than conventional systems, silent operating mode and low maintenance. The by-products from the fuel cells (heat, water and oxygen depleted air) will also have a positive impact on the global aircraft efficiency when they are harnessed and reused within the aircraft system.The HYCARUS project will design a generic PEM fuel cell system compatible of two NEA, then develop, test and demonstrate it against  TRL6. A secondary electrical power generation model for a business executive jet will be run. The application will be tested with the fuel cell system and the storage system under flying conditions. Furthermore, investigations will be made to understand how to capture and reuse the by-products.The HYCARUS project will extend the work already completed in the automotive sector, particularly for safety codes and standards, and develop these for use in airborne installation and applications. Improvements in terms of efficiency, reliability, performance, weight /volume ratio, safety, cost and lifetime under flight conditions at altitude and under low ambient temperatures (mainly in the air) will also be examined.The HYCARUS project also aims to foster a better and stronger cooperation between all the agents of the sector: Aeronautics equipment and systems manufacturers, aircraft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sensor based planning and control for the automatic sorting of recyclablematerial' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Due to the continually rising intake of waste and the further reduction of the capacity of dumps, many countries of the European Community have been seeking solutions for the disposal of waste since the early 70's. Recycling of wasted materials seems to be the most effective way to solve this challenging problem. In general for technical reasons, it is necessary to sort the material by group during the recycling process. Currently, this sorting is performed manually on so-called 'reading conveyor belts'. Unfortunately, this method allows for increasing physical and hygienic burdens on the personnel, mainly through micro organisms, especially fungus and fungus spores. This results in a high rate of absence due to illness, a high turnover among the employees, and low motivation, with evident economic consequences. At the 1996 Hannover Industry Convention, Fraunhofer IPA (the host institution) presented a robotic cell for the semi-automatic sorting of waste: the recyclable material to be sorted is poured onto a moving conveyor belt, where it is identified and localised by the service personnel by means of a touch-screen system. A Scara SR 80 E robot picks the identified waste item, and deposits it in the corresponding shunt. The conveyor belt is covered with a glass plate to protect the service personnel from possible health hazards. The objective of the present project is the full automation of the above cell and the improvement of its performance, through the following steps: - Design and implementation of a vision system for the automatic localisation and gripping of the items on the moving conveyor belt (a proper use of fuzzy logic will allow dealing with the many uncertainties in the available data) - Design and implementation of a sens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Petrifying Wealth. The Southern European Shift to Masonry as Collective Investment in Identity, c.1050-1300' under Horizon 2020.

assistant: **Concept**

Between the years 1050 and 1300 the European landscape turned to stone. It was a structural transformation that led to the birth of a new, long-lasting panorama and helped in the creation of individual, collective and regional identities: a landscape epitomising the way we see the space and territory of Europe. Petrifying Wealth seeks to rewrite the social history of the central Middle Ages, emphasizing the need to reassess from an untried perspective an element that has always been present in our vision of the period—the sudden ubiquity of masonry construction—but which has hardly been given the opportunity to provide in-depth explanations for complex social dynamics. This project seeks to offer novel explanations to previously unasked questions about wealth, building, and collective identity.The speed, extent, and systematization of the construction of churches, towers, castle walls, palaces, and houses within castles and cities provide evidence of an underlying, if unaddressed, issue. That is, it is precisely in the twelfth and thirteenth centuries that the structural link can most clearly be seen between both private and collective wealth, and the investment in stone structures built to last. Our study of the shift involving new institutional dynamics, but also unprecedented social practices, as well as ideological concepts radically different from those that had prevailed until then, aims to break down assumptions that have naturalized this truly astonishing process while using as case studies the undervalued regions of southern Europe to explore the larger questions. By inverting the standard approach that sees the heart of the former Carolingian empire (present-day France and Germany) as the wellspring from which other “peripheral” territories drank, we bring new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification and validation of cerebral KCa3.1/KCa2.3 potassium channels a drug tragets for the prevention and treatment of cerebral ischemia associated with diabetes and Alzheimers disease' in the context of a Seventh Framework call.

assistant: **Objectives**

The objectives of the project are to identify and evaluate potassium channels of the KCa3.1/KCa2.X type as novel drug targets for the prevention and treatment of cerebrovascular ischemia and neuroprotection in metabolic disease and neurodegenerative disorders associated with vascular pathologies, as a new pathophysiological concept and treatment strategy.To reach these aims, the proponent employs genetic models of ion channel deficiency and experimental models of human disease for pharmacological interventions with highly selective small molecule modulators and performs target identification studies on human material. The project will be conducted within the research frame of the Aragonese Institute of Health Sciences and in collaboration with clinical departments of the University Hospital Miguel Servet in Zaragoza, Spain, and the University Hospital Odense, Denmark, and with neuroscientists and pharmacologists at the University of Southern Denmark and the University of California, Davis, United States, for optimal scientific synergy and use of resources.The 1st and 2nd work packages consist of electrophysiological, molecular biological, and imaging studies using genetic and pharmacological tools for “target identification” in cerebrovasculature from murine and human diabetes mellitus type 2 (DM-2), Alzheimer disease (AD), and Morbus Fabry. The 3nd of work package consists of intervention trials and the testing the efficacy of recently developed small molecule modulators in mice models of DM-2 and AD for “target validation”. The 4th work package consists of epidemiological studies in which we define the genetic variability and polymorphisms in KCa3.1/KCa2.3 genes in Aragon Workers Health Study (AWHS)-cohort and evaluate their potential predictive value for disease.Our
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Severe Accident Facilities for European Safety Targets' (SAFEST).

assistant: **Innovation**

Severe accident with core meltdown is a threat to the containment integrity. As Chernobyl and Fukushima accidents demonstrate, significant release of radioactive products into the environment can cause severe consequences both for people's health and the country's economy. Severe accidents are the focus of considerable research involving substantial human and financial resources worldwide. The research field encompasses too many challenging phenomena, complicated by high temperatures and presence of radioactive materials.No individual country has sufficient resources to address all important phenomena within the framework of a national research programme, therefore optimised use of recourses and the collaboration at European and international level is very important. Integrating European severe accident research facilities into a pan-European laboratory for severe accident and corium studies and providing resources to other European partners for better understanding of possible accident scenarios and phenomena is necessary to improve safety of existing and, in the long-term, of future reactors. This unique consortium will be able to address and successfully resolve the variety of the remaining severe accident issues related to severe accident analysis and corium behaviour. It will be a valuable asset for the fulfilment of the severe accident R&D programmes that are being set up after Fukushima and the subsequent European stress tests, addressing both national and European objectives.Joint experimental research is a clear objective in the SAFEST project to provide solutions for stabilisation of severe accident and termination of consequences for the current GEN II and III plants. Consequently, the knowledge obtained in SAFEST shall lead to improved severe accident manage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Artifical spider silk textiles' (ArtSilkTex) under Horizon Europe.

assistant: **Objectives**

ArtSilkTex builds on the ERC-funded project ARTSILK, in which we recently have  succeeded in 1) producing artificial spider silk on a scale that, for the first time, opens up the possibility of producing the material for industrial use and 2) inventing engineered spider silk proteins that can be spun into fibers with significantly enhanced mechancial properties. In this project we will manufacture artificial spider silk yarns that will be benchmarked against commonly used yarns on the market.  The breakthrough potential of an environmentally friendly, biobased high-performance fiber is great and our work is expected to result in a material that can be used or many applications and replace some of the petroleum-based synthetic fibers on the market. To pinpoint which markets and applications that are most suitable to target, get a better understanding of our competitors, and to ensure the best possible prerequisites for taking this material to the market, the project comprise four main activities: 1) generation of an IP strategy, 2) a thorough analysis of the material's life cycle, cost of goods and carbon footprint, 3) generation of artificial spider silk yarns and benchmarking against other materials, and 4) business development including setting up a business plan and the launch of a spinn-off company. We have a strong project team with highly motivated and experienced members with complimentary backgrounds, and we have an established collaborations with large international companies and potential future customers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of additives in composite plating' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The electrolytic codeposition of particles with metals is a technique which has been developed over the past 20 years and has already been implemented as an industrial technique. A large-scale application is e.g. the Ni-SiC coatings in the automotive industry. However the scientific insight into the mechanism of codeposition has not yet resulted into a predictive model. This would be helpful to achieve a better controlled degree of codeposition and to increase the process reproducibility. Moreover no unified theory explains nowadays the effect of additives in composite plating. As such the aim of this doctoral research to investigate the role of additives in composite plating and to understand the way how they can promote or hinder the codeposition of small particles (like oxides and polymeric particles) with metals (like copper a nickel) using advanced investigation techniques like the atomic force microscope and centrifuge plating cell.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The role of tumour microenvironment in metastatic hormone-refractory prostate cancer' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The goal of this proposal is to investigate the role of tumor microenvironment in metastatic hormone-refractory prostate cancer (mHRPC). Prostate Cancer (PC) is the most common malignancy in men in Europe while mHRPC is the most lethal form of the disease, causing over 95% of PC related deaths. Extensive clinical and preclinical research using state-of-the-art tumour models has led to the development of several new therapeutics that, unfortunately, provide only marginal patient benefit. One key element missing in standard preclinical models is the relevant metastasis microenvironment associated with mHRPC that may dramatically affect disease outcome. Here, I plan to significantly advance our understanding in mHRPC associated microenvironment with the first androgen dependent PC bone metastasis model I developed that mimics both the pathology and disease progression in patients. My preliminary data indicate that metastasis associated stromal cells may form a unique bone metastasis microenvironment that promotes mHRPC. I aim to identify the underlying molecular mechanisms using a multidisciplinary approach combining intra-vital microscopy, dynamic ADT resistance reporter system, innovative adoptive transfer approach and genetic tools of lineage specific knockout. This work is also designed to translate findings made in mouse models into human disease using innovative humanized in vivo models of mHRPC. The findings generated in this project will lead to innovative therapeutic approaches that can effectively treat mHRPC thus relieve this lethal threat on European societies. MetResistance will make a step change in the field of cancer medicine research by providing new standards to study therapy resistance of metastatic cancer an area representing the number one challenge in