RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Connecting ethology to the social sciences: A primatological analysis of human bystander behavior during conflicts' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Primatology provided extensive evidence of non-human primate behavior during conflicts claiming a behavioral universality shared with human primates. However, little is known about human behavior during conflicts because direct and undisturbed naturalistic observations of humans are rare. Recently, social scientists started to fill this gap by observing adult human behavior in real-life conflicts using Closed Circuits Television (CCTV). These systematic and unobtrusive observations of adult humans provided evidence for behavioral continuity between human and non-human primates during conflicts but currently lack integration with theories and methodologies from ethology. This project aims to connect ethology to the social sciences by testing theories of bystander conflict behavior from primatology on CCTV camera observations of human adults in 500 conflicts. It integrates methodological standards for observational studies from ethology in the social sciences, and provides motivational explanations of bystander actions in conflicts for the benefits of observational studies in both fields. The integrative methodology adds to both primatology, by providing understanding of human behavioral continuity in the primate order, and to sociology, by providing an evolutionary perspective on human behavior in the context of bystander conflict management. In turn, by conducting the project, I will acquire, as primatologist, an inclusive theoretical understanding of bystander interventions in primates, including the human species that will launch me into an interdisciplinary career.


**Keywords:** Homo sapiens, primates, conflict management, observational method
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Multilingual Joint Word Sense Disambiguation' (MULTIJEDI), addressing dissemination and exploitation.

assistant: **Impact**

In the information society the language barrier represents one of the main obstacles to the automatic use, integration and manipulation of knowledge, and this is manifested in the lack of intelligent systems able to perform unified semantic processing of textual resources in a multitude of different languages. To create such systems, a necessary step is to assign the appropriate meanings to the words in documents, a task referred to as Word Sense Disambiguation (WSD). But while WSD is typically performed in a monolingual setting, in order to enable multilingual processing, the semantic connections between word senses (i.e. meanings) in different languages need to be exploited. However, current state-of-the-art systems mainly rely on the existence of bilingual aligned text collections or limited-coverage multilingual resources to perform cross-lingual disambiguation, an unrealistic requirement when working with an arbitrary number of language pairs.Here we propose a research program that will investigate radically new directions for performing multilingual WSD. The key intuition underlying our proposal is that WSD can be performed globally to exploit at the same time knowledge available in many languages. The first stage will involve the development of a methodology for automatically creating a large-scale, multilingual knowledge base. In a second stage, using this lexical resource, novel graph-based algorithms for jointly performing disambiguation across different languages will be designed and experimented. Crucially, we aim to show that these two tasks are mutually beneficial for going beyond current state-of-the-art WSD systems. The proposed project will have an impact not only on WSD research, but also on related areas such as Information Retrieval and Machine Trans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Chemokine functions in collective cancer cell invasion: induction, guidance and systemic dissemination' (CICCI) targeting Seventh Framework.

assistant: **Abstract**

Cancer progression recapitulates, in part, ill-fated morphogenesis, including single-cell and collective cell migration and associated invasive growth, metastasis and poor prognosis of cancer disease. Chemokines and their receptors enhance cancer progression, by supporting both cancer invasion and proliferation. Previous studies have addressed chemokine function on individual cancer cell functions with emphasis on in vitro effects, yet their contribution to in vivo growth and collective cancer invasion remain unclear. In this project, using state-of the art in vitro and in vivo models, the impact of chemokines and chemokine receptor expression and function on collective cancer invasion and leader-cell function will be addressed. Candidate chemokines identified through in vitro invasion studies will be tested for their ability to guide collective cancer invasion in vivo, using orthotopic 3D matrix cultures and down modulation or overexpression of individual or multiple chemokine receptors. Chemokine-driven collective invasion will be monitored in orthotopic tumor xenografts in nude mice or zebrafish embryos, monitored by intravital microscopy. By inhibiting and/or overexpressing defined chemokine receptor pairs, chemokine-mediated cell sorting and leader-cell function will be monitored. This project will show new functions of chemokine signaling in collective cancer cell invasion, in reminiscence of multicellular movements during embryonic development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Translating Institutions. Digitization of Administrative Data Assets as Redesign of the Modernist State'.

assistant: **Innovation**

Over the last 20 years globalization studies have been posing ground-breaking questions about forms of authority emerging from the disassembling of the nation-state. These studies have questioned long-standing categories of political thought, like territoriality, authority, sovereignty, mainly along the Local/Global and Public/Private divides.From a different perspective, works in the Science and Technology Studies (STS) domain have stressed that the emergence of a new political order is always deeply entangled with the production of socio-technical formations. It is thanks to the engagement with the manufactured milieu that modern political entities redefine the meanings of citizenship, legitimate power, territorial authority, and their constitutional epistemological boundaries.Therefore, since it aims at investigating actors and procedures of authority emerging from the disassembling of the modernist state, the ""Translating Institutions"" research follows the processes through which technology-making interacts with practices of governance-making. By adopting an STS stance, ANT epistemological insights and narrative techniques of analysis, the research aims at demonstrating that, far for simply dragging processes into the ""virtual"" domain, the digitization of administrative procedures in institutional settings is challenging existing institutional orders, triggering emergent actors, divergent information-policy orders and hierarchies, novel subjects of authority and procedures of legitimacy.On a disciplinary level, this research asks whether STS' post-modernist epistemology can undertake a mutually enriching dialogue with political science's insights about novel forms of authority emerging in the global era.The project  aims to strengthen the researcher’s brilliant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Lysosomal lipid logistics'.

assistant: **Objectives**

Lysosomes are the central degradative organelle of all cells and function as logistic centres of cellular metabolite flux. Their dysregulation underlies ~70 monogenetic lysosomal storage disorders, metabolic syndromes, neurodegenerative maladies, and aging, thus affecting an ever-growing portion of the human population. A frequent denominator in these pathophysiological conditions is the deposition of lipids and lipid metabolites in the lysosomal lumen which leads to the accumulation of dysfunctional lysosomes, inflammatory responses, and cell death. The molecular mechanisms governing lipid flux through lysosomes are poorly understood, despite their importance for human disease. My proposed project will provide fundamental insights into the regulation of lysosomal lipid metabolism and thus pave the way for new therapeutic strategies. To achieve this, I will address two key aspects of lysosomal lipid logistics with direct implications in lysosomal lipid-dependent diseases: First, I will systematically interrogate the poorly understood mechanisms that establish and maintain the specialized lipid composition of the lysosomal limiting membrane. Second, I will uncover mechanisms that regulate the export of lipids and their metabolites from the lysosomal lumen into the cytoplasm. Finally, I aim to harness the findings to boost lysosomal membrane biogenesis and upregulate lipid metabolite export pathways to counteract pathologic lysosomal phenotypes in neurodegeneration-driving microglia cells. The results will provide unprecedented insight into the regulation of lysosomal lipid metabolism and will inform novel strategies to alleviate pathological phenotypes in human diseases with utmost societal importance.


**Keywords:** Microglia, lysosomal storage disorders, neuroinflamma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Recyling of rinse waters from metal finishing facilities elimination of organics by catalytic oxidation' (RECYCAT).

assistant: **Innovation**

Objectives and content Recycling process water is a growing need for a variety of industries faced with increasing water costs and environmental constraints. Metal finishing activities such as printed circuit board manufacturing produce large volumes of rinse water slightly contaminated with inorganic chemicals and organic additives. While the former can be removed with proven technologies, there is a need for effective processes for elimination of trace organics in order to allow recycling of rinse waler without negative impact on process bath quality. The objective of the project is to develop a water recycling process adapted to this need, able to remove 95% of the Chemical Oxygen Demand of the rinse water by combining proven membrane separation (ultrafiltration, reverse osmosis) with an innovative chemical oxidation. Other industrial sectors such as the chemical, pulp and paper, mechanical, automotive and textile industries will also benefit from this water recycling technology for a sustainable developments. Two types of advanced oxidations will be specifically investigated: - an emerging technology, catalytic ozonation; - an innovative concept, adsorption with closed-loop sorbent regeneration by catalytic wet oxidation. The consortium combines the competences of Anjou-Recherche-Compagnie Générale des Eaux (CGE) (developer of oxidation processes for water treatment), OTV (designer-supplier of these processes and subsidiary of CGE) with those of Enirisorse (manufacturer of advanced materials), the Universities of Venice and Bologna-INCM (provision of experience on oxidation catalysts), the University of Poitiers-LCEN (research on water chemistry, advanced oxidation processes and catalytic ozonation) and Philips CFT (operational expertise on separation processes for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of the transcription factor Nfix in muscle regeneration and muscular dystrophies' in the context of a Seventh Framework call.

assistant: **Objectives**

I will study the role of the transcription factor  Nfix, in post-natal skeletal muscle growth and regeneration, and in the pathogenesis of muscular dystrophies. I have recently demonstrated the role of the transcription factor Nuclear Factor IX, Nfix, in driving the transcriptional switch from embryonic to fetal myogenesis, characterized by a switch from slow to fast twitching and more mature fibers. Current data show that Nfix is also strongly expressed in satellite cells (SCs), the muscle adult stem cells responsible for post-natal muscle growth and regeneration. Therefore, I will investigate: 1.    The gene expression profile of the muscle specific Nfix null SCs in vitro in comparison with wt SCs.  2.    The ability of Nfix deficient SCs to repair muscle damage in comparison with wt SCs. Moreover, I will study the possible use of Nfix in muscular dystrophies. Muscular dystrophies are characterized by primary wasting of skeletal muscle and currently lack a therapy. Among the different approaches, many efforts are directed to induce hypertrophy in dystrophic to counteract progressive degeneration. This is achieved by enhancing regeneration at the expense of the satellite cell pool. Interestingly, fast muscle fibers are preferentially affected in different muscular dystrophies. As Nfix regulates slow myosin expression, I propose that a slower twitching muscle may escape muscle degeneration in a dystrophic mouse model. In this perspective, the possible interference of Nfix with the pathogenesis of muscular dystrophy will be studied by crossing muscle-specific Nfix null mice alpha sarcoglycan null mice ( a model for Limb Girdle 2D muscular dystrophy) (Aim 3). The results of this study will have important implications for the understanding  of the mechanisms regulating pos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Unified Principles of Interaction' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Most of today’s computer interfaces are based on principles and conceptual models created in the late seventies. They are designed for a single user interacting with a closed application on a single device with a predefined set of tools to manipulate a single type of content. But one is not enough! We need flexible and extensible environments where multiple users can truly share content and manipulate it simultaneously, where applications can be distributed across multiple devices, where content and tools can migrate from one device to the next, and where users can freely choose, combine and even create tools to make their own digital workbench.The goal of ONE is to fundamentally re-think the basic principles and conceptual model of interactive systems to empower users by letting them appropriate their digital environment. The project will address this challenge through three interleaved strands: empirical studies to better understand interaction in both the physical and digital worlds, theoretical work to create a conceptual model of interaction and interactive systems, and prototype development to test these principles and concepts in the lab and in the field. Drawing inspiration from physics, biology and psychology, the conceptual model will combine substrates to manage digital information at various levels of abstraction and representation, instruments to manipulate substrates, and environments to organize substrates and instruments into digital workspaces. By identifying first principles of interaction, ONE will unify a wide variety of interaction styles and create more open and flexible interactive environments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Polarized 2D Materials Inspired by Naturally Occurring Phyllosilicates' (2021-2027).

assistant: **Concept**

Since the last decade, the number of isolated two dimensional (2D) materials keeps growing exponentially. The research community relies predominantly on synthetic single crystals, remaining limited to the variations of only several material classes. Naturally occurring van der Waals (vdW) crystals – 2D minerals – offer wider structural and compositional variety, but remain largely unexplored. Further, developing nanotechnology based on non-toxic and abundant surface minerals found in soils and clays will ensure sustainable, environmentally friendly, and biodegradable electronics.Recently, the focus of 2D electronics is largely on novel semiconductors, and spontaneously polarized materials. The number of vdW insulators is extremely disproportional to both semiconductors and metals. Almost exclusively the entire field relies on hexagonal boron nitride. Surely, this cannot be the only technologically relevant system, and new members would also open unexplored pathways in device design and functionality.With my project POL_2D_PHYSICS, I aim to introduce and establish a class of phyllosilicates as a multifunctional 2D materials platform. My project will explore their limits with respect to three applications: as gate dielectrics, as magnetic insulators, and as ferroelectric insulators. Starting from minerals, I will study their structure property relation. To bridge the gap between an interesting concept and a potential future technology, I will develop pathways to synthesize phyllosilicate single crystals and thin films with targeted properties for applications in 2D electronics.If successful, the project will develop scalable novel concepts in charge transfer doping, and implement the proposed materials class into multifunctional 2D polarization electronics. With high risk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Open Water Management - from droplets of participation to streams of knowledge' (DAIAD).

assistant: **Innovation**

Efficient water management is a challenging issue with the potential to affect the long-term well-being, economy and security of society. Policies for sustainable water management have been established in the EU. However measures to support efficient water use for citizens are currently lacking. Consumers have limited means to accurately monitor their water consumption and thus stimuli to modify their behaviour towards a sustainable lifestyle.A potentially groundbreaking approach for efficient water use and reuse lies within the empowerment of consumers. The principles of open knowledge and participation have provided solutions and driven innovation in similar challenging and complex issues. We believe that a similar bottom up method, in which citizens can voluntarily adopt low cost water monitoring services, self-induce behavioural changes, and accordingly demand better services, can be a catalyst for large-scale changes in efficient water management.The DAIAD  project constitutes an innovative approach for addressing the challenge of efficient water management through real-time knowledge of residential water consumption, bringing together leading members of the water and ICT domains. Our goal is to research and develop innovative low cost, inclusive technologies for real-time, high granularity water monitoring and knowledge extraction. We will devise multi-modal feedback interfaces, recommendation, and analysis services to communicate knowledge and incur behavioural changes to consumers in residential settings. We will apply big data management and analysis technologies to provide efficient management and analysis of real-time water consumption data, as well as multiple relevant data sources. This will enable water stakeholders to gain novel insight and explore the hi