RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Metrics of climate change'.

assistant: **Innovation**

Problems to be solved.In order to quantify the potential climate impact of changing atmospheric constituents such as greenhouse gases" two simple measures have been used, namely "Global Warming Potential" (GWP) and "Radiative Forcing" (RF). These measures are convenient "metrics" allowing estimation of potential climate change in terms of e.g. global mean temperatures from an emission into the atmosphere of greenhouse gases. It has recently been found, however, that these metrics have shortcomings, in particular when considering short lived, chemically active and not well mixed chemical species.Scientific objectives and approachThe objectives are to assess current metrics of climate change e.g. Radiative Forcing and Global Warming Potential as used in the Kyoto Protocol, to refine metrics of climate change suitable for climate forcing agents arising from inhomogeneously distributed perturbations of the atmosphere e.g. aerosols, ozone, contrails and from gases with different levels of thermal infrared optical thickness and different atmospheric adjustment times e.g. CO2 versus CH4 and to evaluate the refined metrics with respect to their usefulness for policy makers. Several cases of localised emission perturbations of ozone precursors will be defined. Using two different chemical transport models, the indirect impact on ozone and other greenhouse gases (e.g., methane) will be calculated and radiative forcing will be determined. Idealised and realistic cases of perturbations of climate change agents will be defined. The equilibrium climate responses to these forcings will be compared using three different general circulation models, and the causes of disagreement will be analysed. A review of available metrics of climate change will be made. Available metrics (like radia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'WEights and MAnufacturing Costs' (WEMACS), addressing dissemination and exploitation.

assistant: **Impact**

This proposal dedicates its tasks to the specification, design and development of a software application to support the CLEANSKY Green Regional Aircraft Design. The WEMACS software suite is intended to become a high-tech, flexible and innovative tool to provide estimation on structural components. Existing know-how on parts will be used to provide accurate estimates on structural changes. The structures focus will be on the wings, fuselage pylons and tail of the aircraft. Parameters on size and geometry, weights and manufacturing costs shall be calculated with depth and accuracy. WEMACS shall obtain detailed weights for structural items taking baseline information previously obtained by conventional methods. It will also derive updated detailed information about costs to manufacture the aircraft. Knowledge Based Engineering (KBE) philosophy is where WEMACS draws its foundation. KBE is the added innovative component in WEMACS, driving progress in the technological implementation of the knowledge management vision and strategy for the aircraft engineering business.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Analysis of volatile non-methane hydrocarbons in air: improvement and harmonisation of the canister sampling and analysis'.

assistant: **Innovation**

The AMOHA project aimed at improvement of NMHC measurement techniques based on sampling ambient air in stainless steel canisters. The project consisted of RTD and intercomparison parts. In the RTD part each step of the sampling and analysis procedure has been investigated, problem areas have been identified and recommendations for the best measurement practice had to be made. In the intercomparison part the analytical proficiency of up to 15 European laboratories has been tested in four annual intercomparisons of increasing complexity.Work programme:Procedures for cleaning canisters, sampling of ambient air, sample preconditioning, separation of individual NMHC compounds, their identification and quantification, preparation of stable standards and testing of NMHC gas mixtures have been investigated in the RTD part. In the intercomparison part we carried out four NMHC intercomparisons using synthetic 4 component, 30 component, 30 component plus pressurised ambient air test samples in the 1st, 2nd, and 3rd intercomparisons, respectively, and ambient air measurements in the 4th intercomparison. The results of each intercomparison were discussed at a workshop in order to obtain feedback on the measurement problems of the participants and to demonstrate that the problems can be overcome. The improved measurement practice has been described in standard operating procedures (SOPs).Currently used electropolished stainless steel canisters proved to be superior for NMHC measurements to silica lined and aluminum canisters, although the latter might offer advantages when other more polar volatile organic compounds are to be measured. Aluminum high-pressure cylinders performed better in terms of NMHC stability for pressurised ambient air sample than stainless steel high-pressure cyl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Plant adaptation in a changing pollination climate' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Pollinator population declines and changes in assemblage composition are among the best documented and most worryDeclines in pollinator populations and changes in the composition of local pollinator assemblages are among the best documented and most worrying consequences of ongoing environmental disruptions. The POLLCLIM project aims to better understand the consequences of these changes in “pollination climate” for animal-pollinated plants. We will develop a novel conceptual framework for analysing plant adaptation to a functionally diverse set of pollinators and apply it in empirical studies of a pollination-generalized wildflower. Through observational field studies, controlled experiments and tailored statistical modelling approaches, we will evaluate the contributions of individual pollinators to natural selection on flowers and other plant phenotypic traits functionally involved in the pollination process, and how well these refined estimates of pollinator-mediated selection extrapolate to evolutionary population divergence.Our conceptual framework emphasizes the (likely non-additive) individual contributions of each pollinator species in pollination-generalized plants visited by a functionally diverse set of pollinators. Building on three years of preparatory work, we will study a set of 50 plant populations in southern Scandinavia. Annual population surveys will inform on phenotypic adaptation to local pollinators, well-replicated selection studies will inform on spatio-temporal variation in selection, single-pollinator flight-cage experiments will allow us to estimate the contribution of each pollinator taxon to selection, and quantitative-genetic analyses will evaluate the relative influence of natural selection and genetic constraints in population divergence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Major depression as a metabolic disorder: The role of oxygen homeostasis and mitochondrial bioenergetics in depression etiology and therapy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

MitO2Health aims to develop and empirically prove a radically new pathophysiological model of Major Depressive Disorder (MDD) as a systemic energy deficiency disease. Traditionally, MDD is conceptualized as a neurotransmitter deficiency in the brain. However, with pioneering methods my group has provided evi-dence for reduced mitochondrial energy production in MDD, characterizing it as a cellular-metabolic disorder with a lowered production of adenosine triphosphate (ATP). Reduced mitochondrial bioenergy production and impairments in oxygen (O2) homeostasis (reduced levels of erythrocytes, less hemoglobin and its lower O2-binding affinity due to oxidative stress), as well as oxidative stress and inflammation (the MitO2Health parameters) were consistently associated with an increased risk for MDD, but have been neglected so far in MDD research and therapy. In MitO2Health we will more comprehensively than ever before investigate the physiological mechanisms underlying MDD and will provide first longitudinal evidence on the mutual in-terplay between the MitO2Health parameters and MDD. Moreover, we will apply cognitive-behavioral therapy (CBT) as randomized treatment condition to test whether CBT-related MDD symptom reduction is coupled to a normalization of the MitO2Health parameters. We will treat 100 MDD patients with 6 months of CBT and compare them to 100 MDD patients of a waiting-list group and 100 healthy controls. Clinical and biological status will be assessed at four points over 18 months. We will thus characterize the biomarker pro-files of MDD treatment response and resistance as well as MDD symptom recurrence during a follow-up pe-riod. MitO2Health will not only establish a modern etiological model of MDD, but also identify biomarkers of individual therapy resp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Open European Quantum Key Distribution Testbed' in the context of a Horizon 2020 call.

assistant: **Objectives**

OPENQKD brings together a multidisciplinary team of the leading European telecommunication equipment manufacturers, end-users and critical infrastructure providers, network operators, QKD equipment providers, digital security professionals and scientists from 13 countries to reinforce Europe’s position at the forefront of quantum communication capabilities globally.The project will create an open QKD testbed to promote network functionality and use-cases to potential end-users and relevant stakeholders from research and industry. Over 25 use-case trials have already been determined and will be complimented by open calls for funding third parties. OPENQKD will develop an innovation ecosystem and training ground as well as helping to grow the technology and solution supply chains for quantum communication technologies and services.In preparation for not only managing a central QKD testbed in Geneva (CH), but as precursor to managing a pan-European network, we will incorporate testbeds in Cambridge (UK), Madrid (ES) and Poznan (PL), along with specific use-case-driven test sites, and develop a virtual network of these islands of security as an interim substitute for a QKD backbone, bringing these distant networks together. OPENQKD will deploy 40 QKD systems with standardized hardware and software interfaces for network devices and protocols on over 1000km of fiber links, as well as testing compatibility with satellite-based schemes.The OPENQKD network will be used to demonstrate the transparent integration of quantum-safe technologies and solutions broadly across the European digital landscape as well as advancing initiatives for the standardization and certification of QKD-enabled technologies. The work in the OPENQKD testbed should lay the foundations for rolling out a p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Early Interception of Inflammatory-mediated Type 2 Diabetes' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The overall concept of INTERCEPT-T2D is to establish whether an inflammatory-mediated profile contributes to the onset of Type 2 Diabetes (T2D) complications, thus enabling the identification of patients most at risk of complications and the design of personalized prevention measures.T2D is a heterogeneous disease, which is an obstacle to the delivery of an optimal tailored treatment. Consequently, patients’ individual trajectories of progressive hyperglycemia and risk of chronic complications are so far difficult to predict. In this context, onset of diabetic complications represents the most important transitional phase of T2D development toward premature disability and mortality. Chronic systemic inflammation has been suggested to be a major contributor to the onset and progression of T2D complications. INTERCEPT-T2D will bring a new and clinically relevant dimension in T2D care considering at diagnosis inflammatory parameters that are of importance for the transition to T2D-related complications. The combination of state-of-the-art genomics and cell-biology technologies with targeted clinical interventions should lead to potent patients’ stratification. It should allow the identification and prognosis of a novel class or subclass of patients characterized by an “Inflammatory-mediated T2D” endotype. The project has access to the best-documented longitudinal human European cohorts of patients with T2D, with reliable clinical and biological data allowing to trace the transition and evolution towards organ complications. This, added to the exploitation of an extensive health data warehouse, will enable us to establish the inflammatory trajectory of citizens with T2D from diagnosis to the development of complications. To explore the ability to prevent the transition phas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Targeted delivery for liver cancer treatment'.

assistant: **Concept**

The Liver cancer drugs market is expected to become an active ground for competition in the future. According to recent market analysis, the liver cancer market in 2009 was valued at approximately US$0.4bn, indicating a growth rate of 27.1% between 2001 and 2009.  It is estimated that the liver cancer market in 2017 will be $1.2bn, with a compound annual growth rate (CAGR) of 15.5% between 2009 and 2017. The growth of the liver cancer market is driven by the growth of the aging population, the greater access to medical care in the emerging new economic regions like China, and the innovative therapies such as targeted therapyIn this project target delivery for liver cancer treatment using biomarker functionalized vehicles is planned. Due to the lack of the needed expertise in one centre or region a consortium is formed. The consortium focuses on the development of nano-vehicle materials for targeted delivery and the relevant practices towards in vitro level of understanding of the effect of the delivery systems on cancer cell treatment. In this consortium, four work packages (WPs) are formed, namely, WP-1: Pharmaceutical materials; WP-2: Formulations; WP-3: Cancer cell imaging; and WP-4: Cancer cell treatment. To support this consortium, biomarkers will be selected from the available products in terms of the functionality of the biomarkers. The consortium comprises 4 partners (2 from EU, 1 from China, and 1 from USA), who are centers of excellence in their unique areas of expertise: Sichuan for preparation of functional polymersomes, Navarra for drug formulations, FIU for cancer cell imaging, and UoW for cancer cell treatment. Most importantly is the development of novel liver cancer therapy, fostering strategic collaborations between EU and China and knowledge transfer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Building materials from waste materials and their durability'.

assistant: **Objectives**

We offer free positions of PhD research workers with the support of the stay by the EU. The research training for the period of 3 till 9 month is offered to PhD students, who are in their work directly involved in the research of building materials. The training will take place in the scientific milieu of the Faculty of Civil Engineering at the Brno University of Technology and will be secured by a prominent team of specialists involved in the building materials development. Each fellow should take part in research activities in one of the following branches of new materials development for the building industry. Mostly under utilization of wastes: Ceramics, Concrete (Technology, SCC, Durability, Rehabilitation), Light building materials, Surface protection, Cements, Blended Cements, Non-Cement binders (anhydrite, gypsum), Thermal Insulation, Recycling of building materials, Radiology, Road structures. The young researchers will get the ability to understand the complex problems of the production of new products from wastes. Further the properties, microstructure, of these materials, the methods and techniques applied in the development of new building materials and the verification of their durability with the application of mathematics, chemistry, physics or mechanics. The students can during their work use independently or with the technical personal the devices of special laboratories: physical, radiological, physico - chemical and microstructure laboratory and the laboratory of building materials. Except of the basic and applied research the students can utilize a very close cooperation with practice and they will be led to use the obtained knowledge in individual conditions of companies in a factual cooperation with realizing firms. They will have the opportunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'consumer grade Ambient assisted living Product family for OLder adult based on indoor LOcation technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

The goal of this project is to allow the recruitment of a very qualified specialist, as innovation associate of Nively, who holds a PhD (or alternative degree) in disciplines related to design of software interfaces (ideally with experience in design of experience for products targeted to old people) or technologies for Ambient Assisted Living. The associate will lead the analysis, and design of a highly innovative product to maximise safety of old people targeted to the home (B2C) market, through re-design of an existing product, called MentorAge, currently engineered for the B2B market. The product will have to be designed based on sound market and usability analysis. The project will allow opening up significant opportunities for Nively through the creation of a brand-new “consumer business unit” targeting the very vast “silver economy” market. The project will also yield a significant opportunity to the associate, who will be then offered to manage the new business unit after the end of the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Co-ordination and Harmonisation of Advanced e-INfrastructures'.

assistant: **Objectives**

Over the past 6 years, the EC has invested to extend the European eInfrastructure technology and European eInfrastructure (and particularly Grid) operational and organisational principles to a number of regions in the world, and reinforcing the close collaboration and exchange of know-how with similar technologies in other areas. A number of different collaboration models have thus been established between Europe and the rest of the world, while the projects implementing these collaborations have had impacts typically focused on their regions. The CHAIN project aims to coordinate and leverage these efforts and their results with a vision of a harmonised and optimised interaction model for eInfrastructure and specifically Grid interfaces between Europe and the rest of the world. The project will elaborate a strategy and define the instruments in order to ensure coordination and interoperation of the European Grid Infrastructures with other external e-Infrastructures. The CHAIN consortium, consisting of leading organisations in all the regions addressed by the project, will ensure global coverage, European leadership, and most efficient leveraging of results with respect to preceding regional initiatives. First, the project will define a coherent operational and organisational model, where a number of EU countries/regions will possibly act, in collaboration with EGI.eu, as bridges/gateways to other Regions/Continents. Further, the project will validate this model by supporting the extension and consolidation of worldwide virtual communities, which increasingly require distributed facilities (large instruments, distributed data and databases, digital repositories, etc.) across the regions for trans-continental research. Finally, the project will act as a worldwide policy-w