RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'NiCE  - Networking intelligent Cities for Energy Efficiency', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

NiCE will promote and advance implementation of the commitments of the Green Digital Charter (GDC).Promoted by EUROCITIES, the network of major European cities, and signed by 23 cities until September 2011, the GDC commits signatories to exploit ICT as enabling technology for reducing CO2 emissions, to demonstrate leadership in adopting innovative technical solutions for delivering on climate change commitments; and to build partnership between the public and private sectors to use ICT as an enabler to significantly reduce energy consumption and CO2 emissions. It is structured into three building blocks:1. Develop GDC Framework and ToolsThe project will develop a common framework and tools for classifying, assessing, reporting on, and supporting city actions in the context of the Green Digital Charter, also with a view of allowing integration with the cities' Covenant of Mayors reporting activities.2. City Support and ActionThese framework and tools will be transferred to cities and their implementation partners through a series of targeted exchange and learning activities with experts and other signatory cities with a view to triggering implementation. A strategy for continued exploitation and support activities beyond the project's lifetime will be put in place.3. Outreach and EngagementNetworking and visibility events will be held to increase the number of signatories and showcase cooperation opportunities with key policy and practices communities, including a special focus on engaging with Chinese cities currently developing similar initiatives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

PAS GRAS aims to prevent and reverse obesity and associated metabolic complications in four age groups: pre-pubertal children (3-9 yr), adolescents (10-18 yr), young adults (19-25 yr), and adults (25-55). PAS GRAS focuses on four main pillars. 1) Develop a personalized risk assessment tool (RAT): an algorithm that will anticipate obesity priming and development in the critical age groups, and identify risk factors for specific complications in subsequent years that will constitute new outcomes for interventional studies. 2) Develop and implement RAT-based personalized interventions by integrating non-pharmacological lifestyle modifications including Mediterranean Diet components alone or with rational pharmacological targeting metabolic and neuroendocrine mechanisms. 3) Inform and engage effectively target groups on obesity causes, risks and intervention by co-production of creative and interactive digital tools (including a simpler version of the RAT) and personalized diet and physical activity programs. 4) Expand and consolidate the PAS GRAS tailor-made campaign across Europe through developing joint programs for health and food/nutrition literacy and physical activity, with healthcare centres, schools, sports clubs, municipalities, and other relevant actors and public authorities. PAS GRAS outcomes will contribute to a long-term 15% decrease in overweight/obesity prevalence in adults and 30% in children/adolescents in the EU until 2050, contributing to a downstream reduction of obesity-associated complications, pharmaceutical and surgical interventions, and to promote Mediterranean Diet as tool for a more nutritious and sustainable future. PAS GRAS is a unique multi- and interdisciplinary research team from 8 countries, including 12 top-level Universities and Researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'In situ remediation of contaminated soils by plants' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Well over 4 million hectares of land in Europe are contaminated with heavy metals. These areas are not only unfit for food production and potentially hazardous to human health, but may also be unsuitable for other forms of sustainable economic development. The remediation of these soils by currently available physico-chemical methods is either very costly or impossible. It has become clear that biological approaches to cleaning up these soils would be more effective, more economic. and more environmentally desirable. To overcome this problem, this proposal will help develop the use of either a special class of pants known as metal hyperaccumulators which can contain very high (up to percent ) concentrations of metals in their small above ground biomass, or non-hyperaccumulating high biomass crop species, and to increase the metal extraction by each. The scientific community agrees that the prerequisites for developing phytoextraction are (a) basic information about the mechanisms by which particularly hyperaccumulator plants access metals in soil and accumulate them in the above ground material, and (b) knowledge of how manage hyperaccumulators or high biomass crops to maximise uptake and-decrease the bioavailable fraction of metals in soils. To achieve this, we have assembled a group of specialists who will use a fully integrated approach to both the intrinsic plant properties and management factors required. Our specific objectives are: (1) to increase understanding of the process of hyperaccumulation, (2) to increase mobilisation and uptake of metals in the rihizosphere of hyperaccumulators or high biomass crops, (3) to give an improved understanding of the agronomy, and management of metal harvesting crops, (4) measure the changes in total and bioavailable metals in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Rebuilding governance and resilience out of the pandemic'.

assistant: **Innovation**

Culminating more than a decade of crisis in Europe, the Covid-19 pandemic has opened an unprecedented window of opportunity for institutional and policy change, not only at the “reactive” level of emergency responses, but also to tackle more broadly the many socio-political challenges caused or exacerbated by Covid-19. Building on this premise, REGROUP (Rebuilding governance and resilience out of the pandemic) aims to: 1) provide the European Union with a body of actionable advice on how to rebuild post-pandemic governance and public policies in an effective and democratic way; anchored to 2) a map of the socio-political dynamics and consequences of Covid-19; and 3) an empirically-informed normative evaluation of the pandemic. REGROUP pursues this threefold objective via a multi-level (national, supranational, international) and multi-sphere (political, societal, ideational, digital) research approach, and guided by three overarching analytical themes: “reordering”; “risk”; “resilience”. We operate in nine collaborative work packages—grouped in three blocks: “diagnosis”, “evaluation”, and “prescription”—bringing together expertise and methods from a range of social sciences and humanities. Doing so, we advance the state of the art conceptually, theoretically, and methodologically. REGROUP is conducted by a consortium of 13 internationally renowned institutions, committed to scholarly excellence, inclusiveness, and open science. The project is designed to achieve a high degree of policy, societal, and scientific impact, which it will achieve via a multi-pronged dissemination and communication strategy. This includes links to some of the EU’s main debates and events, such as the Health Union, the Green Deal, the Digital Decade, the Economic Governance Review, the Conferen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The cognitive neural and genetic basis of face perception' (CNGBFP) targeting Sixth Framework.

assistant: **Abstract**

It is well established that face- processing entails specialized processing mechanisms that are not used for the processing of non-face objects. The current project aims at understanding the nature of these face recognition mechanisms by studying the cognitive, neural and possibly genetic markers of impaired face recognition abilities. To that effect, we will recruit individuals who suffer from developmental prosopagnosia (DP), a lifelong impairment in the recognition of faces, with no apparent brain damage. Using cognitive paradigms, we will assess the nature of the face representation of these individuals and how it differs from the face representation of normal individuals. Using functional MRI (magnetic resonance imaging) we will assess if and how the neurophysiological response to faces is abnormal in DP.Finally, to assess a possible genetic marker for face processing abilities, we will investigate the cognitive and neural correlates of face processing of family relatives of DPs and assess whether they show similar cognitive and/or neural abnormalities. The experience in cognitive and neuroscience methods that I gained during my doctorate and post-doctorate training in the US will allow me to successfully conduct this project and to transfer the knowledge I acquired to students and colleagues in Europe. My plan to continue my collaborations with my colleagues in the Prosopagnosia Centres in the US and London and to establish new inter-disciplinary collaborations with European laboratories will contribute to European scientific excellence and competitiveness.By characterizing the abnormal system, we hope to gain knowledge about the function of the intact face processing system and to promote the development of training techniques to improve face- processing abilitie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Controlling Pervasive Transcription', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The human genome is pervasively transcribed, producing RNA from ~ 80-90% of its DNA, yet only a small fraction of transcripts result in the generation of functional RNAs. Instead, the majority of transcription initiation events are prematurely terminated and the resulting RNA is targeted by decay pathways. How cells determine which RNAs to degrade vs. which to prepare for functional tasks, is a central question. Interestingly, new data from my host laboratory, that motivates this application, suggest that non-productive transcription events are correlated with low transcription initiation levels; i.e. lowly transcribed RNAs appear to be more susceptible to early termination and ensuing rapid degradation. Transcription termination in these instances is conducted by either Integrator (INT) complex or components interacting with ARS2 transcription termination factor. In the present project, I will investigate the mechanisms underlying this relationship, which could possibly rationalize how cells keep their spurious transcription under control. Considering the association of INT and ARS2 mutations with cancer and neurological diseases, my results might also pave the way for therapeutic interventions.Previous approaches utilizing targeted transcription repression/activation by CRISPRi/a approach are based on absolute On/Off transcription from the selected loci without the ability to fine-tune the transcription at a predicted level. Here, I will utilise newly reported mismatch guide RNA/CRISPR-dCas9 to manipulate initiation to defined levels and hereby establish a tuneable system to assay the fate of RNAs expressed from weaker vs. stronger promoters. I will then exploit this system to address the molecular mechanism, dictating genome control based on transcription initiation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Further integrating key research institutions from Southeast Europe into the European Research Area' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

In essence, SEE-ERA.NET PLUS is the next step in further integrating the Western Balkan countries (WBC) and selected key research communities into the European Research Area. It will further enhance the coordination of bilateral R&D cooperation with WBC. By joining forces and by pooling financial resources, the SEE-ERA.NET PLUS consortium will bring critical mass to bear. The main objective of SEE-ERA.NET PLUS is to launch and implement one joint call for trans-national research proposals (JERPs). With a call budget of EURO 3.5 Mio, it is planned to fund approximatly 23 trans-national research projects in the SEE-region. Specific scientific priorities will be chosen for the scope of the call, based on the regional collaboration needs of the participating countries and considering the priorities of the 7th EU Framework Programme on Research and Technological Development and Demonstration (FP7). The JERPs are selected through an independently peer review process. A final comprehensive review will assess the impact of the call and the results at European level. Three reports on the impact of the call, on policy recommendations for future cooperation and on the institutional sustainability of the SEE-ERA.NET PLUS consortium will be prepared and widely disseminated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Role of Beta-Adrenergic Signaling in Cardiac Progenitor Cell Activation after Myocardial Infarction' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Cardiovascular diseases are a leading cause of mortality in the industrialized world with myocardial infarction (MI) being one of the common pathological events. Cardiac progenitor cells (CPC) are a progenitor cell population within the myocardium and are activated after MI to proliferate, migrate to the infarct site, and participate in cardiac regeneration. CPC are a current therapeutic target to diminish cardiac injury after a MI. After a MI, the beta-adrenergic system gets activated due to excessive concentrations of catecholamines accumulating in the myocardium. Interestingly, beta-2 adrenergic signaling has been suggested to promote CPC proliferation. It is currently unknown whether resident CPC could be affected by β-adrenergic signaling therapies. We therefore propose the general hypothesis that beta2-adrenergic receptor signaling after a MI favors the activation of endogenous CPC. We will use a mouse model of MI to evaluate the activation of CPC after treatment with beta-adrenergic agonists/antagonists. CPC will be analyzed by flow cytometry and immunohistochemistry. Cardiac outcomes (infarct size and arrhythmic events) will be correlated to the activation of the CPC. We will further investigate the hypothesis that beta2-adrenergic signaling mediates CPC activation through the regulation of intracellular calcium. We will treat murine and human CPC with beta-adrenergic agonists/antagonists and examine changes in intracellular calcium flux. We will correlate the effect of beta-adrenergic signaling on CPC proliferation and migration in vitro to calcium handling. Validation of our hypothesis would begin to dissect the natural molecular signals that are an integral part of myocardial healing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Beyond Features: Similarity-Based Pattern Analysis and Recognition' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Traditional pattern recognition techniques are centered around the notion of feature". According to this view, the objects to be classified are represented in terms of properties that are intrinsic to the object itself. Hence, a typical pattern recognition system makes its decisions by simply looking at one or more feature vectors provided as input. The strength of this approach is that it can leverage a wide range of mathematical tools ranging from statistics, to geometry, to optimization.  However, in many real-world applications a feasible feature-based description of objects might be difficult to obtain or inefficient for learning purposes. In these cases, it is often possible to obtain a measure of the (dis)similarity of the objects to be classified, and in some applications the use of dissimilarities (rather than features) makes the problem more viable. In the last few years, researchers in pattern recognition and machine learning are becoming increasingly aware of the importance of similarity information per se. Indeed, by abandoning the realm of vectorial representations one is confronted with the challenging problem of dealing with (dis)similarities that do not necessarily obey the requirements of a metric. This undermines the very foundations of traditional pattern recognition theories and algorithms, and poses totally new theoretical and computational questions. In this project we aim at undertaking a thorough study of several aspects of purely similarity-based pattern analysis and recognition methods, from the theoretical, computational, and applicative perspective. We aim at covering a wide range of problems and perspectives. We shall consider both supervised and unsupervised learning paradigms, generative and discriminative models, and our interest will ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A New Intervention for Implementation of Pharmacogenetics in Psychiatry' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Due to the chronic relapsing nature of mental disorders and increased life expectancy, the societal burden of these non-communicable diseases will increase even further. Treatments for mental disorders are available, but their effect is limited due to patients’ (genetic) heterogeneity, low treatment compliance and frequent side effects. Only one-third of the patients respond to treatment. Today, medication selection in psychiatry relies on a trial-and-error approach based mainly on physicians’ experience. Pharmacogenetic testing enables assessing person-specific genetic factors that predict clinical response and side effects. Recent studies show that genotyping of drug-metabolizing enzymes can increase the effectiveness of treatment, which could benefit millions of patients.  PSY-PGx is the first initiative to propose a large-scale non-industry sponsored clinical study that demonstrates the clinical benefits and potential of implementing pharmacogenetics for psychiatric patients in existing medical settings. To this end 1) available biobank data (www.biobankki.fi, www.ukbiobank.ac.uk), with the aid of AI, will be searched for pharmacogenetics that influence medication response. This information is used to 2) perform a clinical trial that will be the first large international, multicenter clinical trial on using pharmacogenetic-based treatment personalization in real-life psychiatric care for depressed, anxiety or psychotic disorder patients. All data is combined with AI to set-up an algorithm for personalizing medication prescription for psychiatric patients that reduces side effects and increases effectiveness of pharmacotherapy. PSY-PGx will thus deliver a new model of care for sustainable healthcare systems and reduce the suffering of psychiatric patients.


**Keywor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The drosophila mitochondrial gamma polymerase - molecular characterization and role in the maintenance of a mtdna deletion phenotype' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The gamma polymerase, which catalyse the replication of the mitochondrial genome (mtDNA) has been recently identified in Drosophila melanogaster and the two genes encoding the two different subunits have been cloned. The aim of the project is to study the promoter region of the catalytic subunit gene. In a first step, with classical experiments (primer extension and S1 protection analysis), We will identify putative important motifs implicated in the regulation of the gene. Once identified, they will be used to study factors which bind specifically to them. These factors will b e further characterized using the one-hybrid system in yeast. In parallel, identification (cloning and sequencing) of the catalytic subunit gamma polymerase gene will be done in a mitochondrial mutant strain of D. subobscura in order to study a possible defect in the gene. This project will allow to extend the current knowledge of the mtDNA replication which is a main aspect of the mitochondrial biogenesis.