RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'European West Nile collaborative research project' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

West Nile virus (WNV) is one of the most evident examples of emerging/re-emerging pathogens one can nominate, which is characterized by occasional virulent epizootic outbreaks. Despite intensive research done since its first appearance in the Americas in 1999, many aspects of its molecular biology, epidemiology, ecology, pathogenesis and life cycle are still poorly understood. Being a generalist pathogen par excellence, its eco-epidemiology is extraordinarily complex, involving hundreds of different vectors and hosts, which differ between locations. In addition, as other RNA viruses lacking proofreading replication, its genome is highly variable and consequently of extraordinary plasticity. As a result, many WNV variants have evolved independently in different parts of the world. As the virus moves from one area to another, either by nature, through migrating birds, or by human influence (commerce and/or other activities), different WNV variants (lineages) from different origins can coexist and co-evolve in a particular area. This is the case in Europe, with at least five of seven WNV lineages identified to date. This situation is clearly different from that of North America. However, most studies on WNV currently come from the USA, biasing the knowledge available not only toward the virus there -a serious bias with important consequences influencing, for instance, diagnostic methods- but also to the WNV ecology in hosts and vectors.In the present Project we propose to conduct comprehensive studies on the WNV situation in Europe and affected surrounding countries that accounting for the peculiarities of WNV eco-epidemiology in this region. Moreover we will strive to cover knowledge gaps regarding its ecology, epidemiology and pathogenesis in Europe. Finally, the Project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polymeric Analogs to Biolubrication Systems' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Lubrication in nature is based on water, but only functions due to the presence of a host of biomolecules. In articular (e.g. hip) joints, it appears that the lubrication system is even more complex than previously believed, involving multiple gradients in structures and properties. Gels and brushes appear to play an important role in biolubrication, while highly confined, highly hydrated charged polymers are key to the important mechanical properties of cartilage. Components such as hyaluronic acid, glycoproteins, and lipids all appear to act synergistically to yield the extraordinary tribological properties of the cartilage-synovial-fluid system. POLYBIOLUB seeks to mimic the mechanisms revealed by the latest studies of cartilage, by means of the synthesis of functionally similar polymeric structures. This is a completely novel approach to the problem, which has the promise not only of revealing structural dependencies of cartilage function, but also of yielding radically new, biomimetic, lubricious, low-wear materials that could find applications in either industrial or clinical environments. The principal synthetic tool will be controlled radical polymerization in a flow environment, involving in situ growth monitoring, followed by a series of postmodification and grafting steps, to yield structures that are lubricious, wear resistant, and tough. These efforts will be accompanied by extensive characterization of composition, structure and mechanical/tribological properties at each stage. Our group has extensive experience in controlled radical polymerization in a flow system, postmodification of polymers, brush-gel and layered polymer systems,. We also have over a decade of experience in water-based lubrication, natural lubrication, synovial-joint studies, and multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'NORTHAMPTON BIOMASS POWER STATION [PHASE 1]' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Bubbling Fluidised Bed Combustion of 120.000 ton/yr of poultry litter based on the Kvaerner Pulping process producing 9,6 MWe during 8000 hours per year (electrical efficiency 23 %). Limestone is injected in the furnace to remove acid gases and activated carbon for dioxins and heavy metals. The ash is recycled as fertilizer after granulation. The innovation is the fluidized bed process application for the poultry litter feedstock and efficient operation without bed sintering and agglomeration. Project has received NFFO support.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Expanded genetic alphabets for orthogonal encoding of genetic information' (OrthoScript) targeting Horizon Europe.

assistant: **Abstract**

In OrthoScript, we aim to build a technology platform for the efficient synthesis, replication and evolution of DNA and RNA comprising alternative genetic alphabets that are either orthogonal to the natural alphabet or expand its combinatorial potential and information density. Our approach involves the leveraging of protein design and evolution approaches to generate bespoke DNA and RNA polymerase enzymes for the encoded synthesis and sequencing of expanded genetic alphabets with high efficiency and fidelity. If successful our approach unlocks the potential of these new alphabets for information storage and enables a systematic investigation of the relationship between complexity (informational density), evolvability and phenotypic diversity in informational biopolymers. The same polymerases are critical for the scalable integration of an expanded alphabet into an orthogonal replisome in a living cell. If realised, we provide a technology platform for the encoding of information in expanded, orthogonal genetic alphabets both in vitro and in bacteria with transformative potential in applications like molecular information storage and genetic code expansion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanisms and Cellular Functions of Molecular Chaperones' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Intense research efforts in the past decade have led to the discovery of the conserved families of chaperones which constitute the cellular system for folding and repair of proteins. They assist the de novo folding of proteins, prevent and reverse aggregation of misfolded proteins and allow their refolding, mediate protein translocation across membranes, and cooperate with proteases in protein degradation. Chaperones are thus fundamentally important for cellular processes and have considerable medical and biotechnological relevance. The fast moving field of chaperone research has entered a fascinating period in which basic molecular concepts of chaperone action are being established. It can be expected that the proposed conference will present many new results and, by bringing together scientists from traditionally separated disciplines including cell biology, genetics, biochemistry and biophysics, will be a major stimulus for the field. The conference addresses open issues regarding the mechanism and cellular functions of chaperones. One topic is the mechanistic dissection of chaperones, which is particularly revealing since high-resolution structures became available. A second topic addresses the roles of chaperones in folding reactions during the life span of proteins, from synthesis to degradation. A third topic addresses the misfolding and aggregation of proteins, which can cause amyloid and prion diseases. An intriguing recent development covered in the conference concerns the influence chaperones have on folding and aggregation states of such proteins.European scientists are among the world-leading scientists in this fleld. To maintain this strong, position, it is of central interest to European researchers to continue the highly successful European conference se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EID on the advanced science and technology of rat models for neurodegenerative diseases' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

One of the most important bottlenecks for finding more effective drugs for brain disorders is the development of model systems that translate to human pathology and are predictive of clinical efficacy. To address this bottleneck PhenoRat will focus on the generation, characterisation and validation of transgenic rat models of two neurodegenerative diseases: Huntington disease (HD) and spinocerebellar ataxia type 17 (SCA17). For this purpose we have assembled a unique consortium in which industry (Noldus Information Technology and Delta Phenomics), academia (University of Tuebingen), and a university-related foundation for entrepreneurship (StartLife) will work closely together to achieve both organization of an excellent training program and excellent research projects with a pronounced focus on intersectoral doctoral education and transfer of knowledge. Two rat models, one already established model for SCA17 and one to be newly generated knock-in rat model of HD, will be behaviourally characterized using a unique integrated system based on video tracking and operant testing in a home cage situation. In addition, innovative behavioural paradigms will be developed to test for the cognitive and emotional impairments typically seen in SCA17 and HD. These findings will be extended with more sophisticated methods to assess fine motor coordination and gait abnormalities. Besides traditional methods of analysis of behavioural data, new statistical methods will be developed to enable behavioural classification of transgenic and wild type animals. This will enable the detection of early onset of specific symptoms and provide read-out parameters in pre-clinical studies applying novel substances for the treatment of HD and SCA17. Last but not least these read-outs will be validate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Water splitting by solar energy: From lab-scale to prototype devices' under Horizon 2020.

assistant: **Concept**

Hematite is a promising photoanode material for harvesting solar energy by splitting water into hydrogen and oxygen. It has a favorable bandgap energy (2.1 eV), good catalytic activity for water oxidation, low cost, is chemically stable in alkaline solutions and environmentally friendly. However, its water splitting efficiency is limited by electron-hole recombination length and it produces a below threshold photovoltage. The key to increasing the recombination length is supressing defects such as grain boundaries or surface roughness of the photoanode. The second issue is successfully resolved by coupling the photoelectrolytic cell to a photovoltaic cell, a so-called tandem cell with theoretically higher efficiency owing to optimal use of the solar spectrum. Both of these drawbacks are accounted for in this project.The aim of this project is to optimize the water photoelectrolysis performance of the photoelectrolysis-photovoltaic tandem-cell device by tailoring the microstructure of the thin film hematite photoanods, and up scaling from the laboratory scale to a prototype device. Fabrication of an efficient water-splitting cell is challenging as it consists of several thin film layers. Each of these layers impacts on the performance of the water-splitting tandem-cell.Up scaling from the lab scale to the prototype scale (10x10cm2) will be carried out in cooperation with PVComB in Germany. This poses entirely different challenges, creating the need for an adapted fabrication sequence and deposition conditions that ensure the adhesion of the ceramic and metal thin film layers. At the end of this project, I personally will have gained expertise in advanced microstructural analysis technique and also in the leadership role, which will enable me to take the next step in my c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Semiparametric Inference for Complex and Structural Models in Survival Analysis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In survival analysis investigators are interested in modeling and analysing the time until an event happens. It often happens that the available data are right censored, which means that only a lower bound of the time of interest is observed. This feature complicates substantially the statistical analysis of this kind of data. The aim of this project is to solve a number of open problems related to time-to-event data, that would represent a major step forward in the area of survival analysis.The project has three objectives:[1] Cure models take into account that a certain fraction of the subjects under study will never experience the event of interest.  Because of the complex nature of these models, many problems are still open and rigorous theory is rather scarce in this area.  Our goal is to fill this gap, which will be a challenging but important task.[2] Copulas are nowadays widespread in many areas in statistics. However, they can contribute more substantially to resolving a number of the outstanding issues in survival analysis, such as in quantile regression and dependent censoring.  Finding answers to these open questions, would open up new horizons for a wide variety of problems.[3] We wish to develop new methods for doing correct inference in some of the common models in survival analysis in the presence of endogeneity or measurement errors.  The present methodology has serious shortcomings, and we would like to propose, develop and validate new methods, that would be a major breakthrough if successful.The above objectives will be achieved by using mostly semiparametric models.  The development of mathematical properties under these models is often a challenging task, as complex tools from the theory on empirical processes and semiparametric efficiency are requ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced Mixed Realities' under Horizon 2020.

assistant: **Concept**

The main goal of AdMiRe is to develop, validate and demonstrate innovation solutions, based on Mixed Reality (MR) technology, which will allow for TV audiences a step change in interactivity, and bring for content creators a radical improvement in talent immersion and interaction with computer generated elements. AdMiRe is focused on sectors where the lead industry partners in the consortium are key players, thus guaranteeing the impact of the innovation and the take up of the technology. At present, TV audiences can interact with the shows they are watching only through social media or HBBTV. Comments, video and audio from the audience may be incorporated into TV program formats, but this is done in such a way that viewer engagement is quite limited and there is not much potential for innovation. AdMiRe will radically change this by producing solutions that will allow viewers at home to be incorporated into the live TV program they are watching and to interact with people in the TV studio. The key innovation here is to use a regular mobile phone to capture the viewer, extract him/her from the background and finally composite the viewer into the studio footage as an MR object. As for content creators, be it in film, TV or live productions, there is an ever growing trend to combine actors and performers with computer generated objects and have them interact. But the number and difficulty of the technical challenges involved have resulted in methods and technologies of reduced scope, resulting in less engaging content. AdMiRe takes the exact opposite approach, producing authoring tools that remove the main technological obstacles and that will allow actors to be immersed in virtual environments, performers to feel at home within the space, and directors to have the opport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FLOW Control Actuators at Aircraft scale manufacturing by SLM with high aerodynamic performance for using in Harsh environment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The main goal of FLOWCAASH project is to design and manufacture reliable and safe flow control actuators at aircraft scale by Selective Laser Melting (SLM) able to withstand the high temperatures (up to 260 °C) and pressures (5 bar) during flight test with aerodynamic performance and high resistance to harsh environments. FLOWCAASH project is focused on the development of innovative designs of Active Flow Control (AFC) actuators to be manufactured by powder bed based additive manufacturing (AM) using Ti6Al4V alloy. Selective Laser Melting (SLM), that utilizes a laser as a thermal energy source to melt the powder has been chosen as the preferred AM technology. The innovative designs of these AFC actuators will allow to be installed in restricted space in the next generation aircrafts with UHBR (Ultra High Bypass Ratio) engines. Two different actuators will be considered, Pulsed Jet Actuator (PJA) and Steady Blowing Actuator (SBA). These actuators will have the potential to reduce aerodynamic flow separation and to increase lift coefficient. This will be obtained by bionic design which allows complex geometries and improve structural strength while reducing the weight. In order to assure process reliability of large Ti parts, distortion prediction numerical simulations will be accomplished. As-built part will be post-processed by means of heat and surface treatments in order to ensure dimensional stability and adequate surface quality for aerodynamic performance.Afterwards the actuators will be validated by aerodynamic and harsh environment tests including rain, icing, sand and dust, vibrations and anti-icing fluid. The FLOWCAASH project will be developed by a well-balanced consortium that brings together 2 partners: the research center LORTEK and the aerospace test labor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Homotopy algebras in homotopy theory and higher category theory' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

We will study in this project exciting new interactions and applications between two fundamental modern research areas of mathematics, homotopy theory and higher category theory. These areas of mathematics are used in applied sciences. For instance, homotopy theory is used in robotics and in computer science. Higher category theory studies the way in which complex structures arising for instance in physics, computer science, biology, can be described by a common language, the one of ‘weak n-categories’. In this project, we apply ideas and techniques from homotopy theory to higher category theory. This will provide new and groundbreaking insights into the latter and will return homotopical applications. We will study certain structures which resembles simple algebraic ones but which are in fact much more complex because the defining data are specified ‘up to homotopy’. These structures are called homotopy algebras. We will then study ways in which a homotoy algebra can be made suitably equivalent to a simpler structure, a strict algebra. This process is called rigidification. We will then apply this theory to weak n-categories. We will view one of the models of weak n-categories, due to Tamsamani, as homotopy algebras, and study its rigidification. This will produce a new important type of higher categorical structure, called weakly globular n-fold categories. These will then be used in applications. We will obtain a new way to describe the building blocks of topological spaces, called n-types, and we will understand their connection with iterated loop spaces. We will also pursue other homotopical applications which will lead to the computation of important invariants used to describe topological spaces.