RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of membrane trafficking in immune cell function' to be submitted under Seventh Framework.

assistant: **Abstract**

Recently, receptor signal transduction has been identified to occur not only at the plasma membrane, but also at various intracellular compartments. Hence, receptor trafficking and signal compartmentalization may contribute to a higher level of cellular organization. The proposal’s objective is to understand fundamental principals in the regulation and biology of membrane trafficking and signal compartmentalization, and to test them in a physiological context. The overall research concept is to study two immune specific regulators for small GTPases, RIN3 and ACAP1, which are involved in the regulation of membrane trafficking and the actin cytoskeleton. In a functional genomic approach, mice deficient for these genes will be generated and lymphocyte signaling and immune cell function/development will be used as a physiological read out to study the biological role of signal compartmentalization. The analysis of knock-out mice will be complemented by biochemical in vitro experiments to further dissect molecular mechanisms of RIN3/ACAP1 function. In addition the potential role of these molecules in the development of immune disorders, such as allergy/asthma will be analyzed. Thus, the study will provide novel insights into the complexity of functions regulated by signal compartmentalization, may have far reaching implications for our understanding of immune cell function in health and disease, and may offer an opportunity to develop novel therapeutical strategies in autoimmunity.  The researcher is an internationally experienced and well recognized expert for membrane dynamics and trafficking. The proposed theme regarding the physiologic relevance of membrane dynamics demonstrates a high degree of originality and innovation in a very promising research field. The host, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects of global change on the social behaviour of marine organisms' under Horizon 2020.

assistant: **Concept**

The IPCC projects a 0.2-0.3 unit decrease in oceanic pH and a concurrent 1.0-3.7°C increase in sea surface temperature by 2100. These changes will have considerable impacts on marine organisms and are a threat to European and global biodiversity, food security, and socioeconomic productivity. While physiological impacts associated with marine global change have been well documented, behavioural impacts are less well known, even though behaviour has a major influence on the structure and function of marine communities. Furthermore, of the documented behavioural changes associated with global change, social behaviours - which play a key role in the survival and persistence of marine animals – are largely ignored. This project thus aims to advance current knowledge of global change biology by testing hypotheses pertaining to the impacts of ocean acidification and warming on the social behaviour of marine organisms spanning a wide range of taxa – from invertebrates to fish. Herein, it is hypothesized that predicted near-future (i.e., 2100) CO2 and temperature conditions will alter the social behaviour of crustaceans (shrimp shoaling), echinoderms (urchin and sea star aggregations), and fish (stickleback shoaling). This project will also test for physiological mechanisms underpinning global change-induced behavioural changes (GABAA functioning), as well as transgenerational effects (transgenerational acclimation in stickleback shoaling behaviour). The training, mentorship, and practical experience associated with this project will provide the fellow with the skills and competency to become an international leader in global change biology and marine animal behaviour. Furthermore, the knowledge generated by this project will answer critical questions in global change biology,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'National institutional autonomy within the EU legal order: uncovering and addressing its distinctive appearances, origins and impact on Member States' administrations'.

assistant: **Concept**

Despite significant advancements in European integration, the institutional design and organisation of administrative structures implementing and enforcing EU law had traditionally remained the responsibility of EU Member States. Over the past decade, however, EU legislation has increasingly come to impose more organisational requirements on those Member States administrative structures. That evolution is most remarkable as EU law has long recognised the existence of a principle of national institutional/administrative autonomy. That principle is to guarantee Member States freedom to designate and structure the administrative bodies responsible for the application and enforcement of EU rules.How far does the EUs more extensive involvement in Member States administrative design decisions actually reach and can one find parallels between different fields of regulation? If so or if not, what are the implications for our understanding of institutional autonomy as a principle of EU (administrative) law? So far, legal scholarship, including the PIs previous work on EU market supervision, has paid only scarce attention to those important questions.The principal objective of this project will be to analyse the scope of Member States administrative autonomy and to uncover, explain and conceptualise the limits that are imposed on it by EU law. To do so, it will first of all map and compare EU laws influence over Member States administrative designs across 18 domains of regulation influenced by the EU. Since the traditional legal scholarship toolkit insufficiently allows to grasp the different factors having given rise to Member States administrative design decisions, the project will subsequently rely on actor-network theory (ANT) to uncover those factors. Using that particular r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A Forgotten Renaissance: The Interplay between Jurisprudence and Humanism (14th-16th c.) and Its Cultural Legacy' (HumanLaw) under Horizon Europe.

assistant: **Objectives**

From the 14th to the 16th centuries, European jurists and humanists worked in the same social milieu, competed for the same political roles, and often shared the same education. Yet, the scholarly consensus portrays these professional groups as indifferent or hostile to one another. HumanLaw challenges this view by revealing a network of mutual influence between jurists and humanists so extensive and significant that its continued oversight is striking.Integrating philosophical, historical, philological, legal, and digital approaches, HumanLaw will illuminate the uncharted interplay between medieval jurisprudence and Renaissance humanism in terms of social interactions, shared references, and mutual intellectual influence. The project will unearth and analyze a vast and neglected manuscript corpus of non-legal works by Renaissance jurists, including philosophical and political reflections, grammatical observations, orations, and poetry. Furthermore, we will use quantitative methods of text and network analysis to trace humanist influences in Renaissance legal literature and to explore the juridical involvement of Renaissance humanists. By examining the humanists’ writings, we will reveal unacknowledged references to coeval legal debates that informed key humanist notions such as virtue, knowledge, politics, and truth. In reconsidering these notions, we will also shed light on their influence on subsequent developments in Western culture, including the debate over universal rights, the birth of modern science, the development of critical methods of inquiry, and the ethico-political theories of the Enlightenment.By challenging traditional narratives, the project will catalyze a paradigm shift in our understanding of the Renaissance and its continuing impact on Western tho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Anti-L1CAM antibody: A novel efficacious immunotherapy for pancreatic and ovarian cancer patients' (Anti-L1CAM).

assistant: **Concept**

Over 170’000 people in Europe and more than 570’000 people worldwide are affected by pancreatic and ovarian cancer. For pancreatic cancer there currently no efficient therapies available and most patients succumb to the disease within 1 year from diagnosis. In ovarian cancer, first line chemotherapy usually leads to good response rates, however tumors recur in 80-90% of patients and in most cases become resistant to conventional chemotherapy, leading to a low overall 5 year survival rate of only 40%. New effective treatments for pancreatic and ovarian cancer are therefore urgently needed.Elthera AG is a Biotech Start-up company created in 2016 in Switzerland with the goal of developing an anti-L1CAM antibody as a novel efficacious immunotherapy for the treatment of pancreatic and ovarian cancer. L1 cell adhesion molecule (L1CAM) is an adhesion molecule, which is expressed on pancreatic and ovarian tumors, and also on a variety of other tumor types including lung, breast, colon cancer and others. It has been shown to promote tumor progression by a variety of different mechanisms, e.g. by directly stimulating tumor cell proliferation and the formation of metastases, by promoting angiogenesis in tumors, and by mediating resistance of tumor cells to chemotherapeutic agents.We have identified a proprietary mouse antibody against L1CAM, which inhibits the cancer-promoting effects of L1CAM, such as tumor cell proliferation and migration and strongly and significantly reduces tumor growth in mouse models of ovarian and pancreatic cancer. The antibody has been humanized and optimized for affinity and stability and is now ready to enter preclinical and clinical development. If funded, the anti-L1CAM project will allow us to establish a GMP manufacturing process and produce a GMP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dynamics of galaxies' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Applications are sought for pre-doctoral fellows to complement their thesis work by a short stay with the Dynamics of Galaxies group of the Observatoire de Mar-seille-Provence, under the Marie Curie training site programme. The prospective supervisors, E. Athanassoula and A. Bosma, have a wide range of complementary skills in theoretical, observational and numerical aspects of galactic dynamics. We will be able to accept two fellows per year. Expertise can be offered in all areas of galactic dynamics, with emphasis on N-body simulations of galaxies and galaxy systems, barred disk galaxy dynamics, and the dark matter content of spiral galaxies. For further information, see our Web page at http://www-obs.cnrs-mrs.fr /dynamique/000dyn1.htmlFellows in this programme work for a Ph.D. degree under the supervision of their home university and department, but visit us for part of their studies, during 4 -6 months, and work under our supervision. A detailed research project in one of the above areas should be described in the application, and candidates are encouraged to contact us beforehand. Good experience in computing is required. Fellows will be offered excellent computing facilities in both hardware and software, and, if needed, access to numerical simulations executed on the dedicated GRAPE computing equipment we operate. The Observatoire de Marseille is centrally located, close to a metro station, and can offer on site housing if desired. The fellowships at our site are open for all non-French students enrolled in a Ph.D. programme in one of the European Union or associate member states. In selecting fellows, we will follow all legal and ethical standards by affirmatively prohibiting any national, racial or sexual prejudice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the mechanisms of antiviral RNA interference in mammals' in the context of a Horizon 2020 call.

assistant: **Objectives**

Organisms such as plants, worms or insects rely on RNA interference (RNAi) to mount an antiviral immune response. On the other hand, it is widely believed that the type I interferon (IFN-I) pathway replaced antiviral RNAi as a primary line of defence against viral infections in chordates. However, recent work from multiple teams, including the host laboratory, has described a possible antiviral role for RNAi in cultured mammalian cells and in mice during infection with different RNA viruses. The importance of RNAi as an antiviral mechanism in mammals remains a matter of great controversy, in part due to a dearth of in vivo studies. In particular, the cell type(s) performing RNAi in vivo remains unknown, as is the relative importance of antiviral RNAi compare to the IFN-I response.  I propose to decipher the mechanism and importance of antiviral RNAi in mice, by answering three main questions: 1) Where is antiviral RNAi happening? I will identify cell types implicated in antiviral RNAi using reporter viruses and permanent genetic marking of RNAi-competent cells. In parallel with these unbiased approaches, I will study antiviral immune responses in specific cell types likely to rely on antiviral RNAi, such as stem cells. 2) How is antiviral RNAi happening? I hypothesise that antiviral RNAi relies on truncated isoforms of Dicer expressed in specific cell types, and/or production of viral DNA as a means of boosting the RNAi response. I will explore both possibilities in detail. 3) What is the importance of antiviral RNAi? I will specifically ablate antiviral RNAi in cell niches that use this defence mechanism to assess its importance with respect to IFN-I.  Overall, my work aims at dissecting antiviral RNAi pathways in mammals and assessing their in vivo significance. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Cinema and Science'.

assistant: **Concept**

The project Cinema and Science (CISCI) is an undertaking to help to raise interest and to improve public understanding ofscience in the young generation. The primary target groups are European teachers and their pupils in schools. CISCI combinesthe most popular media among the young generation, namely movies and the Internet, to help to raise the attractiveness ofscience at schools, to counteract the widely spread misconceptions arising from pseudo-science as well as to raise the pupils'awareness and sensibility of gender-biased representations and public ethical and risk concerns related to science andscientific achievements. CISCI will be available on web-based platforms containing about 160 scientifically relevant and interesting movie clips eachabout 1-3 minutes long from documentaries and popular movies together with related didactical scientific descriptions, commentaries and explanations at a basic (pupils older than 10 yrs) and advanced level (pupils older than 14 yrs) for schoolsmatched to the respective national curricula, and scientific explanations dedicated to the teacher. The content unit issupplemented by multimedia like animations and virtual reality worlds and contains interactive elements. The platforms containalso communication features, search functions, and an online-journal about science aspects in actual movies. CISCI will beimplemented and disseminated through the websites of the CISCI-partners and educational portals or websites of teachersassociations, vocational, educational, governmental and other portal operators. At the end of the project the contents of CISCIwill be available through about 20 websites and educational portals in at least 6 European languages and 8 European countries, and the U.S. with more than one million visitors per mont
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Mass transfer phenomena in methanogenic and sulphidogenic aggregates - characterisation and optimisation based on nmr', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In anaerobic wastewater treatment, Upflow Anaerobic Sludge Blanket (UAS reactors operating under sulphidogenic conditions (COD/SO42- < 1) are an emerging reactor technology for the treatment of sulfate rich wastewater. Unlike methanogenic reactors, few gaseous end products are formed, resulting in inferior mass transfer rates compared to methanogenic UASB reactors.  The aim of this research proposal is to study possible improvement of t treatment efficiency of such sulphidogenic bioreactors by improved mass transfer. Three ways to accelerate mass transfer will be studied: (i) upflow velocity in the reactor, (ii) mixing by gas evolution and (iii) the 'breathing' granule principle. The latter consists of alternate compression and expansion of granules.  The effect of these operational strategies will be evaluated in laboratory scale reactors using specially developed NMR-techniques, i.e. pulsed gradient spin echo-NMR (PGSE-NMR) imaging, PGSE-NMR spectroscopy and chemical shift imaging. NMR was chosen as this non invasive technique provides information inaccessible compared to ex vivo techniques like microelectrodes or confocal microscopy. However, to assess the accuracy and reproducibility of the developed NMR protocols, the effective diffusion and mass transfer coefficients obtained by NMR will be compared to those obtained by microelectrode measurements.  The insight in mass transfer phenomena given by the NMR techniques, in combination with the operation of laboratory scale bioreactors will contribute to the optimisation of the process efficiency of UASB reactors operating under fully sulphidogenic conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Social Sciences and Humanities for Advancing Policy in European Energy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

SHAPE-ENERGY “Social Sciences and Humanities for Advancing Policy in European Energy” will develop Europe’s expertise in using and applying energy-SSH to accelerate the delivery of Europe’s Energy Union Strategy.Our consortium brings together 7 leading academic partners and 6 highly respected policy, industry and communications practitioners from across the Energy, Social Sciences and Humanities (energy-SSH) research field, to create an innovative and inclusive Platform. Our partners are involved in numerous European energy projects, have extensive, relevant networks in the energy domain, and represent exceptional coverage across SSH disciplines across Europe. These enable us to maximise the impact of our Platform delivery within an intensive 2-year project.SHAPE-ENERGY brings together those who ‘demand’ energy-SSH research and those who ‘supply’ that research to collaborate in ‘shaping’ Europe’s energy future. A key deliverable will be a “2020-2030 research and innovation agenda” to underpin post-Horizon 2020 energy-focused work programmes. It will highlight how energy-SSH can be better embedded into energy policymaking, innovation and research in the next decade.Our SHAPE-ENERGY Platform activities will involve >12,114 stakeholders and begin with scoping activities including: an academic workshop, call for evidence, interviews with business leaders and NGOs, online citizen debates and multi-level policy meetings. We will build on our scoping to then deliver: 18 multi-stakeholder workshops in cities across Europe, an Early Stage Researcher programme, Horizon 2020 sandpits, interdisciplinary think pieces, a research design challenge, and a pan-European conference. Our expert consortium will bring their considerable expertise to overcome difficulties in promoting interdi