RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The influence of Aryl hydrocarbon receptor ligands on protective and pathological immune responses' (AHRIMMUNITY).

assistant: **Innovation**

The Aryl hydrocarbon receptor is an evolutionary conserved widely expressed transcription factor that mediates the toxicity of a substantial variety of exogenous toxins, but is also stimulated by endogenous physiological ligands. While it is known that this receptor mediates the toxicity of dioxin, this is unlikely to be its physiological function. We have recently identified selective expression of AhR in the Th17 subset of effector CD4 T cells. Ligation of AhR by a candidate endogenous ligand (FICZ) which is a UV metabolite of tryptophan causes expansion of Th17 cells and the induction of IL-22 production.  As a consequence, AhR ligation will exacerbate autoimmune diseases such as experimental autoimmune encephalomyelitis. Little is known so far about the impact of AhR ligands on IL-17/IL-22 mediated immune defense functions. IL-22 is considered a pro-inflammatory Th17 cytokine, which is involved in the etiology of psoriasis, but  it has also been shown to be a survival factor for epithelial cells. AhR is polymorphic and defined as high or low affinity receptor for dioxin leading to the classification of high and low responder mouse strains based on defined mutations. In humans similar polymorphisms exist and although on the whole human AhR is thought to be of low affinity in humans, there are identified mutations that confer high responder status. No correlations have been made with Th17 mediated immune responses in mice and humans. This study aims to investigate the role of AhR ligands and polymorphisms in autoimmunity as well as protective immune responses using both mouse models and human samples from normal controls as well as psoriasis patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DISTRIBUTED PBX DEVELOPMENT SYSTEM WITH LAN INTERCONNECTION' (DIPSYLAN).

assistant: **Concept**

The DIPSYLAN (Distributed PBX with LAN interconnection) is a single contractor first user action (FUSE) project. The duration of the project was 14 months (September 1st, 2000 until October 31st, 2001). Global Digital Technologies SA (GR) (GDT) is the coordinator of the project. According to the FUSE framework, GDT subcontracted technology provision and transfer activities to SIDSA (ES) and NTUA (GR).The objective of DIPSYLAN is to enhance GDT?s technical capabilities and business process in such way that, by the end of the project, the design, development and delivery of complete prototypes of telecommunications subsystems comprising of both hardware and software would be possible.The focus of DIPSYLAN was in the acquisition of know-how for the development of H/W subsystems and in the adoption of correct business processes for the cost-effective production of prototype and small volume H/W subsystems (at printed circuit board level).OBJECTIVESThe DIPSYLAN project objectives are summarized as follows:- Acquire technology in the area of H/W design and prototyping;- Optimally use the acquired technology through the revision of the company's business process;-Carry-out the DIPSYLAN baseline project (DeReGate)DESCRIPTION OF WORKThe baseline project designed a low cost, compact system with H/W and S/W prototyping capabilities, able to support the development of SOHO communications applications (Intelligent NT, Small PBX, Router, Information gateway etc.) The board integrates the necessary processing capacity and interface support to facilitate S/W development and integration, as well as prototype application demonstration under realistic configurations and system conditions. Low cost and realistic system configuration was achieved with the integration of state of the art com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of protective anti-pneumococcal B cell immunity after immunization.' under Horizon Europe.

assistant: **Concept**

Pneumococcal pneumonia is one of the leading causes of death in children and the elderly worldwide. Pneumococcal vaccines have significantly reduced global incidence of pneumococcal disease, however, current vaccines show varying efficacy among covered serotypes, leading to insufficient level of protection for complete herd immunity. Memory B cells (Bmem) are responsible for high-affinity and long-lasting humeral immunity, and serotype-specific Bmem are associated with increased protection against pneumococcal colonization. Despite their critical role, to date, information on immunization-elicited cellular responses is limited. Here, I propose to characterize pneumococcal serotype-specific B cells for 25 cellular markers, transcriptome and BCR sequence, and link this phenotypic profile with functionality by analyzing recombinantly expressed antibodies. These analysis will involve the integration of 33-colour spectral flow cytometry, 10X next generation RNA and BCR sequencing, B cell cloning, generation of recombinant monoclonal antibodies and functional analysis by antibody avidity and opsonophagocytic capacity. Via computational science, using a data-driven and high-dimensional approach, I aim to identify the phenotypes of protective serotype-specific B cell immunity by analyzing individuals of different ages (children and adults), geographic location (Malawi and Europe) and immunization route (vaccination and colonization). This information will shed light on cellular differences of non-efficient vaccine responses, and may aid in development of improved vaccines. Additionally, the proposed activities and training by experts will be critical for my career development to become an independent researcher in the field of clinical immunology and vaccinology.


**Keywords:*
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Higher Education Leading to ENgineering And scientific careers'.

assistant: **Concept**

Women participation in engineering occupations appears as a key-issue for European economical and technical development, as well as a central achievement towards gender equality and social justice.  Many studies have identified gender-mainstreaming measures in engineering education; for example, the WOMENG project (HPSE-CT-2002-00109) has recently highlighted key-moments for action and recommendations. Yet, other studies have confirmed that successfully implementing such measures requires in each case a tailor-made overall approach to take into account the specific cultural and economical context in which they must be implemented.  The aim of this project is to provide indications about how to launch such measures and monitor the obtained results. The study will be grounded on empirical research about the implementation of selected gender mainstreaming measures in various pilot institutions of engineering education and research all over Europe, including institutions for continuing education and distance learning. After analysing the existing situation, each institution will choose the measures that seem the most realistic and appropriate to its particular case, while implemented measures will have to privilege a global approach from engineering education institutions. They will be intended at the same time for students, faculty and staff and consider transitions from secondary education to higher education and from higher education to academic and industrial professional spheres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimal taxation and the new political economy' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The purpose of this thesis is to integrate political economy concepts into optimal taxation models. A first interesting issue arises when decision are made according to some voting procedure. The existing literature is essentially of positive nature and leaves out the important issue of the design of the political process itself. Normative issues reemerge when one considers the problem of constitutional design, that is the stage at which a society decides upon the rules according to which decisions will be reached in the future. This problem is of crucial relevance for the ongoing European integration process where many issues of << constitutional design >> are still outstanding. The second relevant concept is the possibility of corruption in the decision process. I would like to integrate this phenomena into normative models of optimal taxation and redistribution. Once again, this problem is particularly relevant for the stage of constitutional design and, hence, for the European integration process, in particular as far as the design of (interregional) redistributive policies is concerned.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Dendrimers for photonic devices'.

assistant: **Objectives**

The goal of this interdisciplinary research project is to develop synthetic methods toward new types of dendrimers with tetrapyrrolic core and (indolo)carbazole dendrons, to reveal and analyse physical and chemical mechanisms of control of the luminescence response of dendrimers, and to create a basis for their resulting applications as molecular photonic devices. Combined efforts of synthetic chemists, spectroscopists and theoreticians from Western and Eastern Europe will be applied to achieve this aim. New types of dendrimers with tetrapyrrolic core possessing promising luminescent features, will be synthesized. Physical and chemical mechanisms of manipulation of their optical response will be revealed and analysed with using diverse spectroscopic approaches including steady-state and transient absorption, luminescence, fluorescence line narrowing, infra-red and Raman spectroscopies, luminescence microscopy and single molecule detection at ambient and low temperatures. The two-photon absorption spectroscopy will be applied for the design of infra-red light harvesting antennae and nonlinear optical devices. Theoretical methods will be applied to obtain the optimized molecular conformation of the dendrimers and to establish the pathways of the migration of excitation energy. The realization of this project will lead to the deeper understanding of fundamental processes of light energy transformation in supramolecular systems, which provides the basis for the design of efficient luminescent sensors and photonic devices that will be available for broad implementation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mediating Semi-Authoritarianism: The Power of the Internet in Russia' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

How – and with what consequences – has the emergence of new modes of internet-mediated (i.e. networked, interactive) communication changed our societies in recent years? This is a question that is central to a growing body of communications literature that is often referred to as “mediatization” or “mediation” research. However, while being based on a wide array of disparate theoretical assumptions and methodical approaches, virtually all the current studies on “mediatization” have one feature in common: Their empirical focus lies on western, developed, democratic societies. In the face of this “western bias” of extant research on mediatization, the primary goal of this project is: to take under close scrutiny the mediatization of the political sphere in contemporary semi-authoritarian Russia. To accomplish this goal, this project will seek, for instance, to fathom how common Russians have integrated blogs into their daily news diets and how oppositional politicians make use of blogs as new tools of political communication in the elections in 2011/12. Investigating the Russian case appears intriguing and relevant not only because the country remains a major nuclear and energy power, but also because the Russian internet – in sharp contrast to its Chinese counterpart – is currently not at all being technically filtered. Moreover, at the level of interpretation, a comparative perspective with other (semi-)authoritarian regimes (primarily in Asia and the Arab world) is aspired. Thus, the project will also add valuable and nuanced contributions to the currently ongoing, intense academic debate on the broader question whether the internet in the context of non-democratic regimes is to be seen rather as a “technology of liberation” or as a ""technology of control"".""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular mechanisms underlying BDNF functions in the brain: role of ARMS protein' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Neurotrophins are growth factors including NGF, BDNF, NT-3 and NT-4, which function in cell survival, differentiation, apoptosis, axonal and dendritic growth, and plasticity in the nervous system. Additionally, BDNF has been implicated in human brain pathologies, such as depression, Alzheimer, Huntington, Parkinson, etc. Neurotrophins bind to two different sets of receptors, Trk and p75 receptors, to mediate their functions. Trk activation leads to its phosphorylation in tyrosine and the phosphorylated residues work as docking sites for different adaptor molecules, such as Shc, PLC-γ, FRS-2, SH2B and APS. Recently, a new molecule, ARMS/Kidins220, has been described in association with Trk receptors. ARMS is tyrosine phosphorylated in primary hippocampal and cortical neurons in response to neurotrophins, and is involved in the sustained MAPK mediated by neurotrophins. My work hypothesis is that ARMS/Kidins220 may be an important molecule in neurotrophin functions. For this reason, we propose the study of ARMS/Kidins220 in the differentiation, dendritic branching and neuronal synaptic plasticity mediated by BDNF. The study will be carried out using biochemical and cellular techniques together with molecular biology and genetic approaches. The detailed study of ARMS/Kidins220 will provide a better understanding of the neurotrophin functions as well as the molecular mechanisms that regulate neurotrophin actions and its potential role in nervous system pathologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metallodrugs to Modulate Tumour Cell Machinery', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The past decade has seen substantial advances in our understanding of cancer molecular biology and the technologies available to study it, emphasising the importance of the molecular mechanisms of carcinogenesis in cancer research. We now face having to therapeutically aim for many less common targets rather than a few all-cancer present targets. Effective single molecular targets therapies are generally not sufficient to elicit durable clinical responses and the development of drug resistance is an increasing problem. Consideration of only a single drug–target interaction in vivo has proven to be overly simplistic.The ultimate goal of this proposal is to generate metallodrugs whose mechanism of action is understood and whose targets are identified. These multitargeting drugs would be a more realistic option by leading rational co-extinction strategies for specific cancers.Current cross-discipline trainings make possible the alliance of inorganic chemistry with cell and molecular biology. The unprecedented potential for design of metallodrugs has not been overseen and medicinal bioinorganic chemistry is rapidly expanding.This interdisciplinary proposal involves chemistry, biology and physics, with potential not only for the discovery of novel medicines for cancer treatment, but also for the development of new methodologies to modulate and deconvolute the technology behind the tumour cell machinery. By uncovering the operating principles and mechanisms of action of our metallodrugs at the nanoscale (i.e. subcellular level) we aim to inform on what biological context its destruction would lead to cell death and also to tumour regression.These metallo-medicines will exploit the extraordinary features of transition metal complexes, in particular the capability for in tumour
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Polyester/Polypeptide hybrid biomaterials for biomedical scaffolds' in the context of a Horizon 2020 call.

assistant: **Objectives**

Next generation bioabsorbable and biocompatible polymeric biomaterials are key for the development of new medical devices and advanced approaches in healthcare with significant impact on applicable and affordable treatments for EU citizens. EsterPep will bring together the expertise of the applicant in organo-catalytic synthesis of polyesters with the expertise of the host in synthetic polypeptides and medical applications with the objective to design a new class of poly(ester-peptide) hybrid materials fully based on natural raw materials. The marriage of both systems promises novel functional, processible biomaterials with adaptable material and degradation properties not available from the individual building blocks alone. The objective will be achieved in an interdisciplinary approach combining polymer chemistry and biomaterial science as well as the demonstration of processing feasibility into a biomedical scaffold for tissue engineering. The workpackages have been designed to balance synthetic and application work as well as offering opportinities for intersectorial contacts to benefit the applicants experience. This project is ideally suited to the MSCA-IF programme as it provides mobility and a nurturing, world-class environment for the applicant to embark on a future professional academic career. This will be achieved by developing relevant competences and skills supporting this career path combined with unique scientific training in applied biomedical and biomaterial science guided by a tailored Career Development Plan. The dissemination of research results will target professional audiences as well as communicating to the general public through outreach activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Greek in the West: language communities, migration and the transformation of society in western Europe, 300–700 CE' to be submitted under Horizon Europe.

assistant: **Abstract**

This project reconstructs the place of Greek in the sociolinguistic landscape of western Europe during Late Antiquity (300–700 CE). Integrating textual and epigraphic evidence, it will trace the evolving use and knowledge of Greek in literary and political culture, religion, and daily life. This period witnessed transformations that would change the shape of European history: the rise of Christianity, the fragmentation of the western Roman empire, the introduction of new political and economic institutions, and the resulting restructuring of civic society. Views on the place of Greek in the late antique West still centre around deterministic narratives of ‘decline and fall’, leading to instances of Greek knowledge being dismissed as outliers, thus missing opportunities to examine the period’s continuing cultural, political, and linguistic interactions between ‘East’ and ‘West’. Challenging this consensus, GREEKWEST is ground-breaking in that it is the first study to examine Greek’s changing role in the late antique West and to do so across multiple social contexts. Spoken by roughly half the empire’s inhabitants, Greek had long occupied a central role in Roman society. On the one hand, Greek was seen as a language of high culture and prestige, and educated elite Romans were expected to be bilingual in Latin and Greek. At the same time, Greek was often associated with people from less privileged parts of society: slaves, performers, and merchants. This project seeks a) to establish who knew and used Greek in the late antique West and what sectors of society they came from, b) to reconstruct the motivations for using and learning Greek, and c) to trace how individuals and communities in the West learned and accessed Greek knowledge. This research will fundamentally change