RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High throughput phylogeography of tumors:  how the tissue environment influences cancer evolution?' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The tumor microenvironment (TME) is a dynamic ecosystem wherein tumor cells, immune cells and stromal cells interact and evolve. One of the primary characteristics of cancer progression is the diversification, selection and expansion of tumor sub-clones in manner that largely depends on the TME, e.g., through immune responses or metabolic crosstalk. Advances in single-cell and spatial genomics provide exciting opportunities for studying how tumors evolve in their tissue context, by lending an information-rich perspective on which cell subsets are present and how they might interact. However, fundamental questions, which require the knowledge of how single tumor cells are related sub-clonally, remain challenging to study through that perspective. Fundamentally - what characterizes the immediate cellular environment of successful subclones? Here, we develop transcriptional phylogeography - a paradigm for studying tumor development in-situ, on a transcriptome-wide scale, and at single cell resolution. Our work will leverage studies by us and others that utilized CRISPR/Cas9 mutations coupled with single cell RNA sequencing to infer the lineage structure of thousands of single cells at a time. Adapting this system for in-situ profiling, we will generate the first of its kind phylogeography dataset of a tumor model. This data will allow us to identify tissue locations that harbor critical sub-clonal properties such as unrestrained growth, dedifferentiation, and metastatic seeding, and thereby investigate - through the lens of high throughput genomics- how the TME is associated with these properties. We will also identify and offer solutions for outstanding analytical questions in this nascent area, from lineage inference given sparse data to characterizing the metabolic aspe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation of lesion network mapping as a technique to identify therapeutic targets for brain disorders' (NetworkStim).

assistant: **Concept**

Disorders of the brain are a major source of disability, and place an enormous burden on society. Currently, many first-line treatmentsare non-specific, invasive, or cause side-effects. Non-invasive brain stimulation techniques, such as repetitive transcranial magneticstimulation (rTMS), have been shown to offer a safe treatment alternative, with rTMS first clinically approved for major depression in  2007. Unfortunately since then, translation to other disorders has been slow, mainly due to the lack of reliable methods to identify where in the brain to stimulate. Lesion network mapping (LNM) is a method recently introduced to address this problem. LNM works by mapping the connections of causative brain lesions, converging upon a small number of commonly connected locations in the brain. LNM has localised abnormal networks in over 40 different disorders. However, as yet no study has tested whether these networks respond to treatment. Therefore, the aim of this study is to conduct a clinical trial testing whether rTMS delivered to a specific site in the somatosensory cortex identified in our previously published LNM study (Corp et al., 2019, Brain) results in treatment benefit for cervical dystonia patients. Cervical dystonia is an ideal test case, as changes in abnormal neck movement symptoms are easily measurable, and this somatosensory location is on the surface of the brain, so easily reachable with rTMS. We will employ a randomised, sham-controlled, double-blind, crossover clinical trial, with 30 patients receiving 10 daily sessions of real and sham rTMS. Before and after the brain stimulation, we will collect clinical, behavioural, and physiological data to measure patients’ response to the intervention. Improvement in cervical dystonia symptoms after brain stimula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Nanoelectronics for Electric Vehicle Intelligent Failsafe Drive Train' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The overall objective is to develop sustainable drive train topologies including control concepts for inherently safe electric vehicle power-train. The project focuses on significant steps ahead in terms of: 1. Development of smart electrical power-train concepts comprising high efficiency torque dense motors fully integrated with power converters and storage systems for modularity, compactness reliability and low cost.2. Novel electrical machine topologies involving the use of soft magnetic composites and power electronics packaging and cooling systems suitable for in-motor integration. These will allow the implementation of innovative industrial processes for the manufacturing of lightweight low cost electrical drives.3. Innovative drive train architecture and microcontroller concepts capable of achieving intrinsic fail-safe behaviour of the power-train thus enhancing the overall reliability and safety.The project will address the research on Power and high voltage electronics and smart miniaturized systems up to the subsystems, systems and vehicle demonstrators, encompassing the full supply chain of electric drives for EVs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Combined electromagnetic - circuit analysis of electrical machines', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The aim of this return grant will be to investigate some procedures for machines transient analysis by using the Finite-Element Method (FEM) coupled with circuit equations in two dimensions. It includes two cases: -The first one allows the determination of the machines parameters by means of Finite - Elements simulations in quasi -static -The second consists in time - stepped simulations of transients the symmetrical and asymmetrical short - circuits and the out of phase synchronisation of the synchronous machines, for instance These simulations allow the determination of the winding currents and the rotor torque. Numerical results will be compared with those obtained by experiments. The innovative aspects of the research are: 1) the direct solution of the Maxwell field equations without using potentials as it is done up to now and 2) the use of new approximation vector functions in the Finite Element Method replacing the common scalar ones, which used up to now
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Chiral One Dimensional Enchainment of Metals'.

assistant: **Concept**

Semiconducting polymers have enabled the development of highly successful technologies such as flexible solar cells and OLED displays. Advances in synthetic chemistry allow precise tailoring of the electronic properties of soluble and processable materials. In the coming decades, a transition to chiral versions of these materials could not only enable the emergence of new technologies, including spintronics and quantum computing, but also increase the energy efficiency of OLED displays by 100%.  Existing strategies for developing chiral semiconducting polymers fall short in achieving the necessary performance levels for light polarization, especially when high energy conversion efficiency is required. This highlights the need for a new paradigm in macromolecular design.PolyMetal focuses on the fundamental aspects of chemical synthesis to produce an unseen class of processable chiral semiconductors. Specifically, PolyMetal will develop an innovative class of semiconducting polymers based on one-dimensional chains of metal atoms held in place by helically chiral polymers. To achieve the precise enchainment of metal atoms, we will develop a selective approach to synthesize phosphorus(III)-based polymers, which are highly sought-after for applications in energy conversion and nanomedicine. Selective catalysis will be employed to determine the chirality at the phosphorus(III) centers, introducing a new concept for the control of polymer tacticity and hence material properties. Upon metal coordination and enchainment, all centers of chiral information will actively participate in optical transitions and lead to helically arranged exciton coupled chromophores at a macromolecular scale thereby maximize the circular polarization of emitted light which we will assess in chiral OL
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Intrinsically disordered proteins in health and disease: mechanisms, molecular context and opportunities for drug discovery' to be submitted under Horizon Europe.

assistant: **Abstract**

Proteins dictate virtually all cellular processes. To do so, precise 3D-structures that fit to their binding partners are exploited. However, up to 40% of the human proteome exist in disordered, dynamic ensembles of states mandatory for function. These so-called intrinsically disordered protein and regions (IDPs) play crucial roles in most aspects of life. They mediate tens of thousands of protein-protein interactions involved in cell signaling, scaffolding, transcription, membrane-less organelles and more. While the pivotal role of IDPs in biology is recognized, most of their functions remains unexplored. The time is now ripe for the next frontier, decomposing protein-protein interactions involving IDPs on a large scale. Importantly, IDPs are emerging drug targets for treating complex diseases: cancer, neurodegenerative disorders, metabolic syndromes and viral diseases, afflicting an ageing European population. The evolving field demands a new generation of experts to take the lead in developing different types of drugs targeting IDP interactions. This MSCA DN project aims to educate ten doctoral students within this evolving field by tackling outstanding questions. In particular, we will delineate the role of context in interactions involving IDPs, including flanking regions, folded domains, disease-related mutations, and aberrant cellular signaling and also design peptide-based ligands based on disordered regions that can potentially be further developed into drugs or molecular probes. A team of 14 established scientists from seven academic institutes and five companies, with excellent experience in supervision and cutting edge knowledge on IDPs and experimental and computational techniques will form IDPro. IDPro constitutes an exceptional network where the PhD stude
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'SUstainable nanoPaRticles Enabled antiMicrobial surfacE coatings'.

assistant: **Objectives**

The catastrophic ongoing pandemic has attracted our attention towards the spread of harmful pathogens facilitated by high traffic surfaces, highlighting the importance and urgency of an economically and environmentally sustainable solution for antimicrobial surface as a potential strategy to mitigate the spread of disease outbreaks. Nanoparticle (NP) filled coatings, with recognised effectiveness against bacteria, viruses, and fungi, are valuable candidates for developing antimicrobial surface and minimising the surface adhesion of pathogens. However, due to the many technical challenges, including difficulty to develop nanocoatings with a long-term antimicrobial capability, durability under real conditions and safety assurance, their application at industrial level is still limited.  The SUPREME consortium will develop a platform of efficient and multifunctional antimicrobial nanocoatings, building upon bespoke TiO2 nanoparticles that have demonstrated an exceptional antimicrobial ability at lab scale (TRL3). Two sustainable routes: 1) customised core/shell and advanced functional nanoparticles and 2) hybrid fibre-nanoparticles (using sustainable bio-based cellulose materials and nanoparticles) will be pursued. Bearing in mind the specific requirements of individual applications, the SUPREME consortium will coordinate the antimicrobial testings to its effectiveness against a wide range of pathogens. The production of the SUPREME coating will follow a sustainable-by-design approach that considers both toxicity and environmental impact from outset to guarantee both market acceptance and sustainability of the overall process whilst having a robust safety assurance in place for human health. The scaling-up production of these sustainable materials and their validation acco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'What makes the Danish sound system so difficult for non-native learners?' to be submitted under Horizon 2020.

assistant: **Abstract**

Danish is generally believed to be an especially difficult language to acquire for non-native learners. Since research shows that language proficiency plays an important role in both socio-cultural integration and employability of immigrants, the recent influx of immigrants from non-Western countries to Denmark call for more knowledge on the linguistic problems facing non-native learners of Danish. Nevertheless, Danish as a non-native language is hugely understudied.The problems are generally believed to lie primarily in the intricacy of the sound system, especially in the complex phonological processes. Phonologists have argued that Danish phonology is relatively unnatural due to the amount of discrepancy between the underlying abstract representation and the realised surface form of a sound as well as the many-to-many mappings between these two layers of representation. This analysis has led to theoretical predictions regarding the origins of difficulty, which currently have not been tested. The proposed project aims to test these theoretical predictions by investigating the effect of the different types of theoretically predicted difficulty on non-native speech learning. The effect of the different types of difficulty will be tested both in the comprehension direction and the production direction in order to get a thorough understanding of how unnatural aspects of Danish phonology affect non-native speech learning. The project will be the first to approach non-native speech learning of Danish from a laboratory perspective, thereby extending the scientific domain of the field.The outcome of the project provides a stepping stone to improve language teaching materials for non-native learners and better prepare language teachers, which is clearly called for as research s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bringing a health claim to information: Measuring the impact of health data on the health outcomes of European citizens', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

European Union Members States (EU-MS) share similar levels of development and access to care. Yet, key population health indicators vary widely across countries. The societal burden of these inequalities is high, and leveraging evidence to achieve better health outcomes is a priority. Within countries, Health Information Systems (HIS) are the cornerstone of public health interventions. In Europe however, health surveillance data are fragmented: EU-MS report different items to different international data collection exercises; there is variation between countries with regard to the amount of data collected, how it is generated, and its quality; and there are gaps in information. Whereas we have good mortality data, we are weak on morbidity data, on the quality of care for chronic conditions, and on evaluating patients’ experiences of disease. Overall, there is heterogeneity in the level of evidence that can be used by key stakeholders and in specific health-domains; and we do not know the extent to which differences in health information (HI) capacity might influence on the population burden of disease. This post-doctoral project aims to provide a “HI Impact Index” that could be used by EU public health agencies and policy planners to measure the uptake of evidence into policies and care, and ultimately their impact on population health overall and in priority areas for Europe: maternal and child health, chronic diseases, antimicrobial resistance, injury prevention, and patient reported outcomes and experiences. The research will be hosted at the Belgian Federal Research Institute for Public Health under the supervision of Professor Herman Van Oyen, coordinator of the upcoming European Joint Action on Health Information. This MSCA project is a unique opportunity for me t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The role of microbiome-mitochondria interactions in phenotypic flexibility to cold exposure in Great tits (Parus major)' under Horizon Europe.

assistant: **Concept**

The importance of the gut microbiome has become evident in shaping the ecology and evolution of organisms. Microbiome has been connected to maintaining body temperature in exposure, which can mediate changes at molecular levels and modulate metabolic pathways related to energy regulation. Mitochondria, the powerhouse of cells, is responsible for energy production but also produces heat. Although crosstalk between the gut microbiome and mitochondria has been documented in biomedical research,  to my knowledge, no studies have addressed whether this interaction is also observable in wild animals and what kind of effect it has in energy-demanding situations. Also, existing studies on wild systems rely almost completely on correlative data. I will study the crosstalk between microbiome and mitochondria and its effects on the phenotypic flexibility of cold resistance in Great tits. To my knowledge, this is the first time microbiome-mitochondria interactions are studied in wild birds.  By experimentally manipulating the microbiome and mitochondrial function in wild Great tits I’ll be able to study the causal effects of the experiments on the cold resistance phenotypes of the birds. Thus, MIMIFLEX will integrate cellular-level mechanisms with the physiology and phenotype of the animal. Dr. Ruuskanen’s research group has profound experience in both, studying microbiome and mitochondria which complements my expertise in physiological ecology, allowing me to develop new research skills and opening a two-way knowledge transfer. Throughout the project, I will gain experience in conducting excellent research, but also in transferable skills such as project management, leadership, acquiring funding and communicating the results. Therefore, this fellowship would help me to solidify my
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigating the Mechanism of the FeII/2-Oxoglutarate-Dependent Histone Demethylases by a Combined Biochemical/Biophysical Approach' (2007-2013).

assistant: **Concept**

Histone modifications play important roles in chromatin regulation. Methylation of lysine-residues on histone H3 and H4 affects processes ranging from transcriptional regulation to epigenetic silencing. The recent identification of histone lysine demethylases has clearly demonstrated that histone methylation is not a stable epigenetic mark, as previously assumed. The largest family of demethylases employ 2-oxoglutarate as a co-substrate. Each of these demethylases displays remarkable sequence and methylation-state specificity; however, little is known about the mechanisms by which this selectivity is achieved. For the JMJD2 subfamily of histone demethylases the selectivity for different peptide lengths, sequences and methylation states will be investigated using both biochemical and biophysical approaches. The detailed chemical mechanism of these demethylases will also be investigated using a variety of methods, including EPR, Mössbauer and UV-Visible spectroscopic methods, in combination with more conventional biochemical assays. The oxygen-dependence of these enzymes will also be investigated. Finally, peptide arrays of combinatorially-modified histone peptide fragments will provide insights into the ability of these demethylases to recognise and demethylate multiply-modified histone sequences. Overall, these studies will provide molecular detail on how chromatin is regulated by histone demethylases.