RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role, regulation and targeting of nucleic acid-sensing TLRs within the tumour microenvironment' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Inflammation is an integral part of carcinogenesis. Several different cells of myeloid, lymphoid and non-hematopoietic origin contribute to the strong link between cancer and inflammation and maintain a pro-tumoral environment. The complexity of this environment and the diversity of tumours lead to distinct responses during tumour immunotherapies. Nucleic acid-sensing (NAS) TLR ligands are an essential component of anti-tumour strategies to induce efficient tumour-specific adaptive immune responses. NAS TLRs can also detect nucleic acid released during tumour necrosis, thereby modulating the tumour microenvironment. Interestingly, NAS TLR signalling can induce cell death via apoptosis or induce pro-tumoral survival and proliferation of cancer cells.  These opposing effects of NAS TLR ligands may be due to the differential response of distinct tumour-associated cells to TLR ligands. Indeed, the individual response of subsets of tumour-associated cells remains unclear, thus making it difficult to predict the outcome of tumour immunotherapies. Furthermore, the expression and regulation of NAS TLRs in tumour-associated cells remains unknown. Using ex vivo cultures from adenocarcinomas and melanomas, we will systematically analyze the expression of all NAS TLRs on sorted cells. Using cutting edge technologies, we will dissect the role of TLRs in modulating the tumour microenvironment, which will provide novel insights into our ability to modulate cellular inflammation in the tumour. This proposal has the potential not only to reveal novel aspects of NAS TLR regulation, but also to provide new targets for the modulation of the tumour stroma and the infiltrating cells during carcinogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of the molecular mechanic valence method - mm vb - with application to the mechanisms of photochemical reactions' (1994-1998).

assistant: **Innovation**

The group of Professor M. A. Robb has completed the initial development and software implementation for the combination of quantum mechanics (Valence Bond VB) with molecular mechanics (MM). The MM-VB method enables very large systems to be studied. Program : The following developments are envisaged : - The existing package must be improved in its efficiency and design - The VB part of the method only concerns bonds making/breaking between carbon sites. The parametrization must be extended to other atoms (hydrogen, nitrogen and oxygen for example) - The method is not time-consuming. It would be therefore very interesting to develop Dynamics methods within the MM-VB formalism Applications : The following examples of possible applications are of interest : - The dynamics of photochemical reactivity in polyenes and aromatic hydrocarbons - Efficient generation of organic intermediates from diazirines (carbenes) and azoalkenes (biradicals)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sensing as a Service', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Water utilities face growing challenges due to urbanization, water scarcity, rising energy prices, and aging water supply networks.To improve resource efficiency, utilities are integrating smarter technology in their networks. However, there are some constraints that make implementation difficult, such as reasonable and easy access to sufficient power for technological solutions. Furthermore, these solutions need to be pieced together using different components from various manufacturers (sensors, battery, data logger, connectivity and software). In addition, experts are needed to making the entire system work. With our self-powered and smart plug-and-play sensors,we provide more data to water system managers and help them better understand and manage their pipe networks.


**Keywords:** Water,Service innovation,Business model innovation,Environmental and Green Technologies,Network infrastructures,Digital services
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Clean Label Enhanced and Redefined Upcycled Starch' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The increasing demand for pulse protein concentrates and isolates reflects a shift from animal to plant-based diets. At the industrial level, producing high-protein fractions from pulses generates significant starch co-products. However, native starches often lack the functional properties needed for food applications, leading to their undervaluation or use as animal feed, which poses both environmental and economic challenges. While chemical modification is commonly employed to enhance starch functionality, this method does not meet clean or green labeling standards, highlighting the need for more sustainable solutions.The project aims to develop a high-throughput green process for producing functionalized starches, understand the relationship between starch structure and functionality, and identify starches suitable for controlled-release applications.Specifically, I will use atmospheric pressure plasma jet and enzymatic treatments to modify starch co-products, creating enhanced starches with porous and branched structures. Advanced analytical techniques, including field emission scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffraction, and size exclusion chromatography, will be employed to investigate the effects of multi-scale structural modifications on starch functionalities. Additionally, I will explore the use of caffeine as a model compound to evaluate the ability of the modified starches to function as controlled-release systems.Overall, the project will address a significant research gap and provide sustainable solutions for utilizing starch co-products, supporting the European agri-food system’s sustainability goals. It will contribute to reduced waste, enhanced food safety, and increased market competitiveness through the dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Catalytic abatement of n2o and nox from combustion power plants ('CADENOX')' to be submitted under Fifth Framework.

assistant: **Abstract**

The proposed project aims to develop an advanced and cost-effective catalytic technology for the system for the simultaneous abatement of N and NOx degrading emissions from oxygen rich exhaust of combustion plants. The development will be based on the selective catalytic reduction of N and NOx by hydrocarbons. Sometimes, external hydrocarbon addition could be necessary depending on its level in the exhaust, but in this way, the project is expected to have a wider applicability. Even in that case, the required amount is below the costly equivalent one of conventional SCR-systems. Due to the presence of poisons in combustion off-gases, practical applications require the development of highly active and selective catalysts stable over a meaningful time of operation. The process approach will be evaluated by catalyst development and lab- and bench scale experiments. The work will be supported by basic studies and catalyst characterisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease' to be submitted under Horizon Europe.

assistant: **Abstract**

MASLD is the condition of excessive accumulation of liver fat unrelated to alcohol intake, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH). With a 25% prevalence in the general population, MASLD is currently the most common liver disease, and a major healthcare and economic burden. While hyperlipidaemia, obesity and insulin resistance are the major risk factors for MASLD and contribute to its rising prevalence, growing evidence suggests that exposure to endocrine-disrupting chemicals (EDCs) can initiate and/or cause progression of MASLD. EDC-MASLD will focus on investigating the impact of environmental exposure to EDCs on the internal exposome (metabolome, gut microbiome, epigenome, proteome, immunome) and degree of liver damage in MASLD in prospective study settings, with a focus on the period of transition to progressive stages of MASLD. EDC-MASLD is particularly focused on interactions between EDC exposure, sex, genotype, diet, socioeconomic and lifestyle factors, via the data and biosamples available in the unique European NAFLD Registry, comprising over 9,000 patients with histologically characterised MASLD. EDC exposure studies will be performed in murine models of MASLD, zebrafish models, and human 2D/3D in vitro models, with an aim to understand respective mechanisms-of-action and to develop novel EDC screening tools. The EDC-MASLD consortium has diverse and complementary expertise in the domains of hepatology, endocrinology, toxicology, exposome research, metabolomics, systems biology, environmental economics, and communications & technology research, with respective PIs being global leaders in their fields. Taken together, EDC-MASLD will significantly contribute to the actions centred on identification and mechanistic a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Functional and genetical characterization of Ccbe1, a novel regulator of lymphangiogenesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Ccbe1 has recently been identified as an essential regulator of lymphangiogenesis in zebrafish. Loss of function of this secreted factor leads to a failure of lymphangioblast budding and a complete lack of lymphatics. Intriguingly, mutations in human CCBE1 are causative for a congenital lymphatic malformation disease, termed Hennekam syndrome (HS). The main goal of this project is to understand the function of Ccbe1 in development and disease. Firstly, since the mode of action of Ccbe1 is completely unknown, we will focus on identifying interaction partners for this secreted protein by three different approaches: (1) I will test the interactions between Ccbe1 and one potential binding partner identified in a yeast-two-hybrid assay (2) I will perform IP experiments with myc-tagged Ccbe1 protein, followed by Mass Spectrometry for protein identification. (3) I will analyze an additional gene causing HS, identified in the human clinic. For all three approaches, candidate genes will be validated further through expression pattern analysis in zebrafish and mouse, in conjunction with functional tests through morpholino injections and co-IP studies with Ccbe1 in zebrafish. Secondly, I will focus on analyzing Ccbe1 conditional mouse knock out models. Using inducible and constitutive tissue specific Cre-recombinase lines, I will identify those tissues and cell types which require Ccbe1 activity for their normal physiological functioning. Particular attention will be on the role of Ccbe1 in those organ systems that are affected in HS patients, i.e. the lymphatic system and the brain. Furthermore, the inducible knockout of Ccbe1 in adult mice will answer the key question whether Ccbe1 is also required during adult stages for lymphangiogenesis. CCBE1 is one of very few genes known t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SENSE-PARK: Supporting and Empowering Parkinson patients in their home environment using a Novel SEnsory information system that monitors daily-life-relevant parameters of PARKinson disease and their' (SENSE-PARK), addressing dissemination and exploitation.

assistant: **Impact**

Parkinson's disease (PD) is the second most common neurodegenerative disease, and prevalence increases with age. This leads, in an aging society, to increasing personal, social and economic burden. To date, basically only symptomatic treatment is available, which application almost always leads to the feeling of dependence and lose of self-control in (a) person(s) with PD (PwP's). A further shortcoming in PD-related treatment is the limited quality of disease state-defining parameters. Recent ICT-associated projects have mainly been focusing on the observation" of the user rather than giving feedback to him/her, and they bear little resemblance or application to the reality of living with PD. In addition, obtrusive measurements influenced results in particular in PwP's due to disease-caused neural network changes.The aim of the SENSE-PARK project is to develop an unobtrusive and empowering information system for use in the home environment, which provides the users with practical, engaging and motivating tools to monitor patterns in their condition. In more detail, the SENSE-PARK system will inform the users about motor and non-motor functioning in daily life activities ('being', data collection via RFID sensors and a wrist-worn data logger), leisure activities ('belonging', data collection via gaming console and adapted interface) & scientific environment ('becoming', for validation).The project will include PwP's at central positions to ensure the development of a user-friendly and effective system, and consequent dissemination. In addition, with the SENSE-PARK system, disease course-associated parameters which are provided to the user can also be provided to the doctor, to enable an intense and transparent at-the-point discussion between two specialists of the diseas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Functional Photonic Crystal Devices for Metropolitan Optical Networks' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Optical networks continue their growth in the metropolitan core and access segments. The FUNFOX project addresses the use of photonic crystals (PhC) to miniaturise and improve semiconductor optoelectronic devices needed in these networks. It focuses on InP-based devices exploiting advances made in the FP5/IST PhC-related projects PCIC and PICCO. It gathers for a three year duration 380 personmonths through nine partners, including 7 academic laboratories, a large industrialist and a SME, with a total cost above 3.3 Meuros.Three device-oriented workpackages address (i) active functions, (ii) passive functions and (iii) the active-passive integration. They cover the most relevant device aspects for metro networks.Active functions to be demonstrated during the project are highly linear optical amplification and wavelength conversion. Passive functions exploit novel schemes permitted by photonic crystals, either for spectral selection, notably in relation with monitoring and multiplexing, or for polarisation management (i.e. polarisation diversity). Integration of wavelength selective functions with single-mode lasers will result in wavelength-stabilised laser sources. Integrated devices performance will be assessed through a  system  testbed in the fourth main workpackage. The objectives take into account the emerged knowledge of losses in two-dimensional photonic crystal structures. It exploits both the 'membrane' and the 'conventional heterostructure' approaches of the former FP5/IST projects, and in particular their combination by bringing their advantages into a single device.All these devices, with improved performance and high degree of integration, thus potentially low-cost, will contribute to future large scale deployment of metropolitan core and access networks fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fast - development of an automatic system for cheap and reliable real-time fabric inspection on the loom' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The work consisted in the collection of the user requirements in order to have an accurate definition of the system specifications (Task 1). The next step was the development of the defect database for the definition of the neural network training set in parallel with the design of the vision hardware (Task 2). Based on the specifications defined in task 2, the Vision Equipment has been developed in parallel with the feature extraction software (Task 3). Finally a mechanical system was developed in order to integrate the different sub-systems in a basic prototype (Task 4) to have an evaluation of the system performances (Task 5).The following results have been achieved:-Collection of the training-set of fabric defects;-Development of the Integrated Vision Camera;-Development of the Feature Extraction software installed on the Integrated Vision Camera;-Integration of the vision hardware and lighting system for the development of a Scanning Head prototype;-Development of the mechanical hardware and interfaces to the Scanning Head Driver;-Development of the control software for the Scanning Head Driver;-Development of the Defect Detection and Classification software.The objective of the project is to develop an automatic system (FAST) for the realtime detection and sorting of faults during the weaving of a fabric to provide the textile SMEs with an efficient, cost effective tool for monitoring and improving the production. Currently there are no systems available on the market to automatically detect the faults directly on the loom. The inspection of fabrics is presently performed by human operators. This solution is expensive and not reliable. Attempts have been made in recent years to introduce automatic systems but the high costs, the frequent need for assistance, and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A point-of-care serological rapid diagnostic test for risk of Plasmodium vivax hypnozoite infection (PvSeroRDT)' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Plasmodium vivax is considered the most difficult species of human malaria parasite to eliminate because of the inability of conventional diagnostics to detect individuals who carry dormant liver forms and sustain malaria transmission. The consortium has developed the first diagnostic test that addresses this problem. PvSeroRDT aims to develop a point-of-care (POC) rapid diagnostic test (RDT) to transfer the consortium’s validated lab-based test to the field to support implementation of the P. vivax Serological Test and Treatment (PvSeroTAT) malaria control strategy.      The PvSeroRDT specific objectives are: 1) Develop a POC RDT using lateral flow technology to measure antibodies to four P. vivax proteins that are biomarkers for the dormant liver-stage of P. vivax. 2) Establish Africa-based manufacturing capacity at DIATROPIX (Senegal) following RDT development at Abingdon Health, a UK-based SME specialising in lateral flow assays.3) Validate RDT performance with bio-banked samples, followed by field-based clinical validation on freshly collected samples in Ethiopia and Madagascar.4) Develop a clear regulatory strategy to streamline market authorization and access to this first-in-class P. vivax serological testing. PvSeroRDT addresses all expected outcomes and impacts of this call topic and work program, respectively. Specifically, it will contribute a robust POC diagnostic to the pipeline in sub-Saharan Africa (SSA) and enable the implementation of the AU-EU Innovation Agenda for public health. The project is designed to address the WHO’s preferred profile for P. vivax diagnosis, to translate an SME prototype to Africa-based industrial design, and to test clinical performance in several SSA sites, thus enhancing international cooperation in SSA and improving trainin