RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development and mechanistic investigations of efficient Fe-catalysed asymmetric C–H activation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The importance of chirality in bioactive molecules is well established with only one enantiomer exhibiting the desired biological activity. To date, more than 90% of chiral drugs on the market are supplied as racemates potentially causing side-effects or of uncertain bioactivity. The enantioselective synthesis of chemicals has risen to address such issues with enantioselective catalytic C–H activation standing out due to its atom economy, step efficiency, and avoidance of substrate pre-functionalization. So far, metal-catalysed enantioselective inner sphere C–H activation relies mainly on precious and/or toxic metals, such as Pd and Ru, limiting the reaction’s applicability. Therefore, efforts are currently being made to replace such metals with more benign 3rd row transition metals. Nevertheless, only one report of such transformation has been reported with Fe despite Fe being extremely desirable due to its low cost, toxicity and high natural abundance. The AsymFeCH project will address this issue through the development of non-toxic, sustainable and inexpensive Fe-catalysed enantioselective C–H activation reactions. For this purpose, low valent Fe complexes with chiral phosphines will be used as precatalysts in the catalytic hydroarylation of allenes or alkenes with aromatic ketones. The mechanism and origin of enantioselectivity of the developed reactions will then be delineated through a unique combination of spectroscopies and kinetic studies. Subsequently, the acquired mechanistic understanding will be used for further reaction development with more challenging substrates (imines and 1,1-diphenylketone derivatives) setting the foundations for the scientific and industrial communities to advance the field of asymmetric Fe-catalysed C-H activation. This will not onl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'John Hume and the Creation of the European Dimension in Ireland' (JHCEDI).

assistant: **Innovation**

John Hume and the Creation of the European Dimension in Ireland will investigate how John Hume helped to create the conditions for a diverse constituency in Northern Ireland to reimagine its political and cultural identity in Europe. The kernel of JHCEDI is a research question that has not been adequately addressed in the literature on Hume, or on Ireland in Europe: How did Hume’s reconceptualisation of Ireland in Europe facilitate the peace process in Northern Ireland? This project could hardly be more timely: a thorough public awareness of the history of Northern Ireland in Europe through the lens of its key political actor, Hume, over the past half-century could provide a vital contribution to public discourse and attitudes towards the future. Today three pillars of considerable geopolitical significance – the threat to the Good Friday Agreement, the disruptions of Brexit, and the ongoing controversies that surround the Northern Ireland Protocol – give urgency to JHCEDI. No work yet exists that fully transcends the paradigms in which Hume has been framed by situating Hume’s project in the paradigm of nation formation in a European tradition as well as in ethnic studies. This is the gap in the literature that JHCEDI will address. The vision he shared with t of a Europe of regions and of shared sovereignty was at once a transnational priority for Hume and a strategy to resolve Ireland’s internal dilemmas. The objective of JHCEDI is to investigate how Hume helped to create the conditions for a diverse constituency in Northern Ireland to reimagine their political inheritance. The outputs of JHCEDI will be the articles and the public dissemination of my findings, being essential actions to lay the groundwork for my monograph in this subject.


**Keywords:** Democracy, hum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Smart Multifunctional silica-based Nanoparticles for Targeted Therapy'.

assistant: **Innovation**

NanoSil4Cancer project will be able to accelerate the uptake of nanotechnologies, by developing, mesoporous silica-based prototypes of nano-vehicles, according to an innovative and proprietary approach (EP06745236), active in smart chemotherapy. This is aimed to minimize toxicity and the side effects of the traditional antitumor agents and to increase their therapeutic potential. This technology platform enables customers’ molecules to be formulated as pH–sensitive pro-drugs and introduced in smart nanoparticles able to reach the intracellular compartments of cancer cells where the drug is released. Development of new prototypes will lead to new patent applications. Recently we have developed and optimized a device, provided with folic acid, able to manage bortezomib release in cancer cells overexpressing folate receptor, FR (PCT-13511). The nanoparticles are only recognized and internalized by FR overexpressing cancer cells, where they release the drug, sparing normal cells. Nevertheless, our technology is general, not limited to a specific prototype, but depends on customer's needs, market and final users' needs. The feasibility study will individuate strategical market interests to address the prototypes production as business opportunities for our SME. Market trend and the role of Big Pharma will be defined to identify commercial partners and stakeholder to be involved in the project. We will buy sectorial report, we will use patent search such as EPO and Thomson, we will acquire missing competence in marketing and communication. The approach will represent a strong step forward in chemotherapy, improving the efficacy, lowering drug dosage (thus minimizing side effects for cancer patients and environmental impact), other than dramatically lowering EU Healthcare cost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ab initio Statics and Molecular Dynamics Simulation of Olefin Metathesis Catalysts for pharmacological purposes' under Seventh Framework.

assistant: **Concept**

The computational calculations nowadays do not act as a support element for supporting experimental results. Now we have taken more ambitious roles, going forward and saving time and money to the experimental sector. Thus we will tackle existing unexplained effects in olefin metathesis, including no stability, no or low activity, deactivation of the catalysts. By means of DFT, the design of more active catalysts will render the method of wider use as a tool for molecular assembly, rendering syntheses simpler and faster by reducing the number of required reactions to obtain the desired molecule, thus a reduction of the amount of waste produced too.The science outlined impacts the pharmaceutical world in numerous ways.Several quantum mechanics studies have been performed to rationalize the mechanism of olefin metathesis promoted by Ru-based catalysts. However, with the single exceptions of an old study on an oversimplified system, and 2-3 projects, all the computational results published to date have been obtained with static techniques. The dynamic studies are able to escape from the limits of our understanding of this important reaction.Half of the project is focused on an ab initio molecular dynamics simulation of Ru-catalyzed olefin metathesis. Taking advantage of the state-of-the-art ab initio molecular dynamics simulation CP2K package the dynamic characterization of the metathesis reaction pathway from reactants to products will be investigated. Free energy surfaces connecting the reactants to the Ru-metallacyclobutane key intermediate and finally to the products will be reconstructed from the simulations. Furthermore, simulations will be also performed to clarify the isomerization pathways that connect different reaction pathways corresponding to different geometri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Energy and climate change' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

Specific ObjectivesThe project develops along two activity lines, namelyA) Support to the EU Energy Policy- Contribution to the pan-JRC Energy Technology Observatory activities (mainly on the economic analysis of technologies and technology foresight);- Development and maintenance of a technology characterisation database including the relevant information to conduct energy/environment/economic (E3) analyses. The support of an ESTO action is foreseen for this task;- Development of a systematic database on regulatory and legislative issues concerning renewable energy (subsidisation schemes)- Contribution to the Energy Technology Observatory activities (mainly on the economic analysis of technologies and technology foresight);- Contribution to the Energy Technology Observatory activities (mainly on the economic analysis of technologies and technology foresight)- Development of a world energy technology outlook, as well as alternative scenarios, incorporating a number of state-of-the-world hypothesis, including technology costs, resource endowment and institutional framework;- Analysis of security of supply issues. Elaboration of forecasts on prices and resources, with particular attention to the natural gas supply in the EU;- Specific support to Policy Papers by DG TREN, concerning various issues;(transportation, renewable, industrial regulation)B) Support to the EU Environmental policies;- Techno-economic analysis of carbon mitigation instruments within the European bubble. The task would support the EU position in the post-Kyoto negotiation rounds. The different regimes of tradable pollution permits and/or joint implementation/clean development mechanisms are the key issues to look at. This has to be developed in support to the Emissions Trading Directive;- Technology d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Through Amateur Eyes: Film and Photography in Nazi Germany' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Through Amateur Eyes is a single-authored book that marries archival research with theoretical and historical interpretation to put forward a study of the role of amateur documentary films and photographs in the memory and memorialization of World War II and the Holocaust. The images to be researched are taken by self-identified Nazis in Germany between 1926 and 1943. The project explores the images’ formation by and influence on forces that shaped the social structure and visual culture of the Nazi period: technological developments, cultural and social events, aesthetic trends. The project approaches this images from a unique perspective: it privileges their status as amateur films and photographs, and holds their status as products of self-identified Nazis in abeyance.    Because many of the images are recycled in contemporary narratives that memorialize World War II, Through Amateur Eyes also analyses the recyclings as cues to contemporary beliefs and practices of cultural memory. The re-presentation of archival images is found in museum and gallery exhibitions, television documentaries, magazines, documentary films, and the World Wide Web. The recyclings are found in mainstream and alternative media since 1995 in Western Europe and North America.  The approach to the amateur image as a site of European culture from a simultaneously German and Anglo-American perspective guarantees the project’s intervention in the urgent ongoing debates about the events that took place, their visual representation and how to continue to remember them today. The project will be the first of its kind, setting new standards for the writing of history through images, and introducing new methodologies to the study of film and photography as historical documents. Ultimately, it’s methodol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Personalised Guide for Eating and Activity Behaviour for the Prevention of Obesity and Eating Disorders' (SPLENDID) under Seventh Framework.

assistant: **Objectives**

The emergence of eating disorders and obesity as major health concerns increased research in these fields. However, impressive advances in neurobiology, genetics and sociology of eating had minor clinical or sociological impact. In obesity, pharmacological interventions have failed and while life-style interventions seem moderately successful, they are embedded in specific social contexts. In the field of eating disorders traditional interventions have poor results and high levels of relapse. Our central assumption, validated in randomized control trials, is that supervised training of patients to eat and move in a non-pathological way is effective in the prevention of both eating disorders and obesity. The logical next step is to apply the same kind of methodologies to the general population, in real life by combining expertise in identifying and modifying behavioural patterns with current technical advancements in the fields of sensors and intelligent systems. SPLENDID aims to develop a Personalised Guidance System to help and train children and young adults to improve their eating and activity behaviour by detecting subjects at risk for developing obesity or eating disorders and offering them enhanced monitoring and guidance in order to prevent further disease progression. To this end it will monitor key parameters of eating and activity, such as food intake, meals structure, snacking, daily physical activity during real life; evaluate in real-time and offer guidance towards recommended behaviours. Four studies in Sweden and Netherlands will evaluate:(i)a screening programme conducted at school settings during daily meals, with the aim to assess the children's eating behaviour, and (ii)the capability of the system to offer correct and effective guidance on eating/act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fast non destructive evaluation of large structures with loss angle lockin thermography' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Research objectives and content Acoustic waves propagating in a material undergo hysteretical losses of power with consequent generation of heat (loss angle effect). Loss angle lockin thermography is able to provide images of internal defects based on the heat generated by loss angle effect. Corroded areas, delaminations, cracks can be easly visualized. The aim of this project is to develop and test loss angle lockin thermography as a powerful non destructive evaluation technique, whose preliminary results showed to be extremly promising for rapid inspection of large surfaces. This technique has also shown to be able to reveal irnportant defects not detectable with others techniques, marking a significant progress in the field of non destructive testing. Training content (objective, benefit and expected impact) The candidate will benefit from an experience in a laboratory endowed with the newest and most sophisticated techniques. Being involved in the development of this new technique will provide the candidate with a broad experience in ultrasonics, thermography, new and advanced materials, mechanics of fracture and corrosion. This experience will also put the candidate in direct contact with the research centers of industries that already showed their interest. Links with industry / industrial relevance (22) ABB has provided samples with defects not detectable with other techniques than loss angle lockin thermography and showed a great interest in the development of this new technique. Branson, an important company producing ultrasonic welding machines, has shown a greet interest and is willing to cooperate in the project. Industries like Eurocopter, MTU, and others, involved in non destructive testing of structures, showed interest in this technique. AGEMA is natural
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Aerospace Districts: Acceleration of the Strategic Transfer of Regional Advancements' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

AD-ASTRA (Aerospace Districts: Acceleration of the Strategic Transfer of Regional Advancements) is a project about the positive interconnection among innovation ecosystems, with a focus on aerospace sectors.The proposal aims at the development of a connected, competitive, interregional innovation ecosystem between 5 EU regions (Toulouse, South Holland, Madrid, Apulia, Emilia-Romagna) with: a shared interest in fostering aerospace sectors, enhancing the cross-contamination to and from other innovative sectors (e.g., automotive, biomedical, agri-food, big data); different innovation readiness levels; aerospace districts with different levels of maturity and consolidation. “Diversity generates wealth”: the collaboration of these markedly diverse regions, furthermore represented by partners from different spheres of the quadruple-helix, will be a growth opportunity. The establishment of a solid and long-lasting collaborative EU network, able to exploit complementary skills, experiences, territorial and industrial vocations, will contribute to create a “critical mass” in EU strategic sectors such as innovation and aerospace, where global competition leads to a confrontation with actors of increasing size and requires innovative models and approaches.This ambitious goal will be achieved through an iterative process: starting from the collection, analysis and systematization of the experiences (competencies, technologies, networks) of the partner regions with reference to their aerospace districts; analyzing the future evolutions of the ecosystems, in response to technological, economic, political, and social megatrends; correcting or validating hypotheses and evolution models with the support of stakeholder groups; defining an action plan for the development of each of the re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Effective co-delivery of therapeutic peptides and intestinal permeation enhancers using a double Pickering emulsion oral delivery system' (OraPickering) targeting Horizon Europe.

assistant: **Abstract**

Therapeutic peptides (TPs) are one of the fastest growing classes of therapeutics with clinical applications in severe and/or chronic diseases like cancer therapy, hormonal or immune disorders, and infectious or metabolic diseases. To date, most TPs can only be administered by invasive injection, which greatly influences treatment costs as well as patient compliance and wellbeing, as e.g. diabetic patients rely on regular insulin injections. Oral delivery of TPs poses a convenient alternative to circumvent these problems, but it is highly challenged by I) the harsh gastric environment detrimental to TPs and II) the poor permeability of the intestinal epithelium to TPs. To tackle these problems, I propose a novel oral delivery system for TPs based on a unique gastric stable Pickering double emulsion, which is able to I) protect TPs from degradation in the gastric environment and II) co-deliver hydrophilic TPs and hydrophobic permeation enhancers (PEs) to the absorption site; the intestinal epithelium surface. Simultaneous co-delivery of TPs and PEs is crucial, but not often achieved. As key deliverables, OraPickering will establish Pickering double emulsions for the encapsulation of hydrophilic TPs and hydrophobic PEs, explore their stability under gastric conditions, and confirm their efficacy and safety for intestinal TP delivery in vitro and in vivo. To implement OraPickering I will join forces with Prof. Nielsen from UCPH, combining my background in material and interface sciences with her expertise in TP delivery and intestinal permeation models and mechanisms. I consider this the ideal environment for my further career development, to learn relevant techniques for drug delivery and gain further experiences to emerge as an independent group leader. In summary, OraPi