RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Calcium, the backbone of fish culture: Importance in skeletal formation, reproduction and normal physiology' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The first objective is to identify the relative importance of the different sources of calcium during critical phases of development, growth and reproduction during a normal production cycle on a fish farm. The second objective is to determine experimentally whole animal calcium homeostasis during larval development, vitellogenesis and normal growth and the role of PTHrP in maintaining homeostasis. These will be related to observations of calcium requirements and balance made on the fish farm. The third objective will be to determine the molecular mechanisms, which underpin bone formation in fish and the way in which PTHrP regulates this process.The PTHrP gene promoter(s) will be identified and used to characterise factors, which may influence its expression in vivo. Genes differentially expressed during endochondral bone formation, and thus strong candidate genes for this process will be isolated and their regulation by PTHrP determined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Relationships between Energetic Status and Population Parameters in Seals' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In light of global climate change, reliable tools to assess status and trends of animal populations are essential to support efficient species conservation management. This project is aimed at identifying the impact of environmental changes on population dynamics of top marine predators by studying how fish availability affects fitness and survival of seals in the North Sea. We will first determine how changes in fish availability affect bioenergetics and foraging behaviour of seals through controlled laboratory experiments on captive seals mimicking different environmental and food conditions. Using these data, a dynamic bioenergetic model will be built to determine energy budgets in relation to foraging, age/size class, season and prey availability variables. We will then estimate how this translates into changes in fitness, survival and reproduction in seal populations based on foraging behaviour of wild seals recorded using telemetry equipment. From these, a state-space model will be developed to estimate age, fecundity, and juvenile survival rates as functions of differences between energy requirements and intakes and of environmental parameters. Finally, we forecast future population trends as well as potentially times and places where seals might be most sensitive to environmental changes. This will be done by linking the previously mentioned state-space model to environmental conditions and prey distribution predictions to estimate spatial and temporal location profitability and seal survival. This interdisciplinary approach will combine laboratory experiments, tracking data from free-ranging seals and complex state-space and spatio-temporal model analyses. It will contribute to advancement in marine mammal ecology by providing essential physiological and behavi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Computational Symmetry for Geometric Data Analysis and Design' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The analysis and synthesis of complex 3D geometric data sets is of crucial importance in many scientific disciplines (e.g. bio-medicine, material science, mechanical engineering, physics) and industrial applications (e.g. drug design, entertainment, architecture). We are currently witnessing a tremendous increase in the size and complexity of geometric data, largely fueled by significant advances in 3D acquisition and digital production technology. However, existing computational tools are often not suited to handle this complexity.The goal of this project is to explore a fundamentally different way of processing 3D geometry. We will investigate a new generalized model of geometric symmetry as a unifying concept for studying spatial organization in geometric data. This model allows exposing the inherent redundancies in digital 3D data and will enable truly scalable algorithms for analysis, processing, and design of large-scale geometric data sets. The proposed research will address a number of fundamental questions: What is the information content of 3D geometric models? How can we represent, store, and transmit geometric data most efficiently? Can we we use symmetry to repair deficiencies and reduce noise in acquired data? What is the role of symmetry in the design process and how can it be used to reduce complexity?I will investigate these questions with an integrated approach that combines thorough theoretical studies with practical solutions for real-world applications.The proposed research has a strong interdisciplinary component and will consider the same fundamental questions from different perspectives, closely interacting with scientists of various disciplines, as well artists, architects, and designers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An experimental investigation of the effect of conduit flow on the fragmentation of magma during plinian-style eruptions' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The effect of conduit flow on magma fragmentation during plinian-stile eruptions will be investigated combining the following information:i) literature data on natural pyroclasts, that will provide the working hypotesis and a comparisonfor experimental tests and their results, respectively;ii) literature data from numerical simulations of magma flow in the conduit, to provide the information about the state of magma and flow conditions prior to and at fragmentation;iii) experiments on the rehology of bubble suspensions of analogue viscoelastic materials during fast cylindrical flow, expected to provide the key parameters for a scaled model of the process;iv) fast decompression experiments on hydrated synthetic silicate melts that will show the actual behaviour of magma under the expected conditions the goal of the project is to investigate the relationships between conduit diameter and shape, flow conditions, and magma fragmentation, aiming at constraining the fragmentation criterion to be included in numerical simulations of eruptions and to provide new clues for the reconstruction of past eruptions from their products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stochastic Transport in Upper Ocean Dynamics' (STUOD) under Horizon 2020.

assistant: **Objectives**

71% of Earth is covered by ocean. The ocean has absorbed 93% of the heat trapped by human’s greenhouse gas emissions. The ocean’s future responses to continued warming are uncertain. Our project will deliver new capabilities for assessing variability and uncertainty in upper ocean dynamics. It will provide decision makers a means of quantifying the effects of local patterns of sea level rise, heat uptake, carbon storage and change of oxygen content and pH in the ocean. Its multimodal monitoring will enhance the scientific understanding of marine debris transport, tracking of oil spills and accumulation of plastic in the sea.  Our approach accounts for transport on scales that are currently unresolvable in computer simulations, yet are observable by satellites, drifters and floats. Four scientific capabilities will be engaged: (i) observations at high resolution of upper ocean properties such as temperature, salinity, topography, wind, waves and velocity; (ii) large scale numerical simulations; (iii) data-based stochastic equations for upper ocean dynamics that quantify simulation error; and (iv) stochastic data assimilation to reduce uncertainty. These four scientific capabilities will tackle a network of joint tasks achieved through cooperation of three world-calibre institutions: IFREMER (ocean observations, reanalysis); INRIA (computational science); and Imperial College (mathematics, data assimilation). Our complementary skill sets comprise a single systemic effort: (1) Coordinate and interpret high-resolution satellite and in situ upper ocean observations (2) Extract correlations from data needed for the mathematical model (3) Perform an ensemble of computer simulations using our new stochastic partial differential equations (SPDE) which are derived by matching the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Imaging Voltage Gated Sodium Channels Using Positron Emission Tomography' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Voltage gated sodium channels (NaVs) are the primary transmembrane proteins underlying fast electrical communication in neurons of the peripheral and central nervous system (PNS and CNS). Being such an integral part of neuronal signaling, they are implicated in a number of severe diseases that have a major impact on human society. However, drugs and established therapies targeting NaVs are rare due to common off-target effects. Therefore, new NaV-blockers will be developed and used for in vivo imaging using positron emission tomography (PET). For this purpose, novel derivatives of the recently disclosed truncated batrachotoxin (tr-BTX), which represent a completely new type of NaV-blockers, will be synthesized and their ability to block different NaV isoforms (NaV1.1 to 1.8) will be tested using fluorescent assays. The most promising candidates will then be labeled using different positron emitting isotopes such as carbon-11 (11C) and fluorine-18 (18F) exploiting different radioactive half-lifes and metabolic stability. The resulting “hot-tr-BTX” will be subsequently employed in small rodent PET-scans revealing their in vivo pharmacokinetics. This novel and unique tool will provide three major immediate benefits. First, hot-tr-BTX might deliver a general imaging probe for nervous activity in the PNS, and potentially the CNS, by monitoring NaV function in vivo. Secondly, this will allow the investigation of various pain conditions and neurodegenerative diseases and link their pathogenesis to NaV-function. Thirdly, the proposed research might deliver not only new NaV-blockers as potential drug candidates, but will also provide a valuable method facilitating the development of long awaited drugs targeting NaVs for pain therapy, a goal that is currently intensely investigat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A Ferrosilicon Latent Heat Thermophotovoltaic Battery'.

assistant: **Objectives**

THERMOBAT will develop an innovative Latent Heat Thermophotovoltaic (LHTPV) battery for long duration storage (10 to 100 hours) and combined heat and power (CHP) generation. The system stores electricity in the form of latent heat at very high temperatures (1200 deg C) using a new kind of ferrosilicon alloy with very high energy density (> 1 MWh per m3) and converts it back to electricity and low-temperature heat (< 70 deg C) on-demand using solid-state Thermophotovoltaic (TPV) devices. The value proposition is the supply of a very cheap system (< 10 Euro per kWh) that has a very high energy density (> 400 kWh per m3), high global efficiency (> 90 %), that is safe, flexible, compact, silent, recyclable, scalable, and able to produce clean heat and electricity on demand. The dispatchable CHP generation capability of the LHTPV battery will be demonstrated in a sport center that is managed by one of the largest Spanish companies dedicated to the design, maintenance, and operation of infrastructures. THERMOBAT builds on the results (demonstrated proof of principle) achieved within the FET-OPEN project AMADEUS in which a small lab-scale prototype of the system was built and tested. THERMOBAT will bring LHTPV technology closer to commercialization by developing scalable, low-cost, and environmentally friendly processes for the manufacturing of the key components of the LHTPV battery. In addition, we will focus on accelerating tech-to-market activities through Thermophoton, a recently established UPM spin-off company that will receive UPM's know-how and will develop a detailed business plan to make the innovation fully marketable. This tech-to-market plan is also a continuation of another EU funded project named NATHALIE (FET Innovation Launchpad) in which the market and the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EmpoweriNg (European) SME business model InnovatiON' (European), addressing dissemination and exploitation.

assistant: **Impact**

Reaching the ambitions of the Europe 2020 and the Innovation Union requires much more than just technological innovations. In the academic community, Business Model Innovation (BMI) has for a long time been recognized as the key to improved competitiveness and innovativeness. However, BMI does not reach SMEs yet nor is there knowledge on how SMEs conduct BMI in practice.Empowering SMEs to conduct BMI requires new approaches. By leveraging existing networks and communities, we will gather examples, best practices and insights into Business Models (BM) from case studies from each and every European region or industry, complemented with insights from other leading countries worldwide. The BM vortex will thus generate an enormous and rich library of business models patterns and managerial structures, provided on a platform,  to support SMEs in these communities. We will also develop innovative tooling and provide them on the platform to makes it easy for SMEs to develop, evaluate and plan new business models. The ENVISION consortium covers Northern, Western, Central, Eastern and Southern Europe. In each region a top-ranked academic institution in the field of BMI is present as well as innovative businesses that deliver smart and tailored BMI tooling and reach out to SMEs. We build on over a decade of joint work on BMI and BM tooling. We will build and maintain regional and thematic communities. In the communities, support is delivered to help SMEs transform and improve their BMs. The consortium also includes partners and associated partners that will realize our pan-European reach to SMEs: on a pan-European level (e.g., UAEPME and female entrepreneurs’ network), on a national and regional level (e.g., chambers of commerce, family business organizations and statistical offic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'L-type Calcium channels in health and disease' under Sixth Framework.

assistant: **Concept**

Disturbances in ion channel function lead to serious diseases of the nervous system, skeletal and cardiac muscle, and intestine which makes ion channels important drug targets for the pharmaceutical industry. Calcium currents through L-type voltage-gated C a2+ channels (L-VGCCs) play a key role in the cellular signalling in brain, heart, smooth muscles, sensory (e.g. inner ear, retina), and endocrine cells (e.g. pancreatic islets). In distinct cells of these organs, the pore forming 1-subunits Cav1.2 and/or Cav1.3 conduct Ca2+ currents that are required for their function. To address the important question about the differential contribution and functional communication of these L-VGCC isoforms and their potential role in other tissues an already existing net work of collaborating scientists will be complemented by excellent researchers providing the required advanced research methods and front-end ion channel expertise. As Cav1.2 and Cav1.3 show an overlapping expression pattern in a variety of tissues and sub unit-specific antagonists or agonists are not available so far, genetic tools are urgently needed to dissect the specific roles of both Cav1.2 and Cav1.3 in normal and pathological function. This consortium will complement its existing mouse models by new ones and will apply state of the art molecular biological, electrophysiological, Ca2+ imaging techniques and behavioural analyses to reveal the physiological role and pharmaco-therapeutic potential of these channels with a special focus on various diseases (e.g Alzheimer, epilepsy, arrhythmias, diabetes, tinnitus, deafness). The long standing and complementary expertise of the network partners will not only advance our understanding of the role of individual L-VGCC subtypes in health and disease but also provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Time in Intercultural Context: The Indigenous Calendars of Mexico and Guatemala' (TIMEINTERCULTURAL).

assistant: **Innovation**

European libraries and museums hold a small corpus of – still quite enigmatic – ancient screenfold manuscripts from the Aztecs, Mixtecs, Mayas and other indigenous cultures in Mexico and neighbouring Central America. The central structuring principle of these pictographic and hieroglyphic texts is the prehispanic calendar, which was not only the dominant framework for historiography and astronomical observations, but was also used for divination, medical treatment, ritual performance, community organisation and moral codes. The comments from authors writing shortly after the Spanish conquest (A.D. 1521) are crucial, but give a generalised, incomplete and biased picture. A wealth of additional and very relevant information is still to be found in the on-going use of this calendar by “daykeepers” (specialists in traditional healing and other rituals) in contemporary indigenous communities in the region. So far, however, little attention has been paid to this fascinating cultural continuity, which is very rapidly disappearing.This research project, then, has three interrelated aims.1) To document the endangered knowledge, ideas, practices and oral literature related to the indigenous calendar, still in use in Mexico and Guatemala, through simultaneous ethnographic fieldwork in seven indigenous regions: PhD cands, PI, field assistants, documentary-video team.2) Connect the resulting data and insights to the historical information in order to extract an in-depth interpretation and reading of the ancient manuscripts, which in turn will lead to a better grasp of the symbolic meaning and social function of time in Mesoamerican thought and culture: PhD cands, PI.3) Produce a comparative and theoretical analysis of the role of perceptions and conceptualisations of time in the con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Zero discharge aquaculture by farming in integrated recirculating systems in Asia' to be submitted under Fifth Framework.

assistant: **Abstract**

The project ZAFIRA (Zero discharge Aquaculture by Farming in Integrated Recirculating Systems in Asia) will focus on the combination of Western recirculating and traditional Chinese Techniques to outline a zero nutrient discharge facility. Different (local and commercial) feeds will be evaluated in growth experiments for salt and freshwater fish. Different treatments with ozone will be tested to valorise the sludge for later use through the production of single cell protein by bacteria or to be used as feed for nereis or sea cucumber. The each organism the nutrient balance and growth performance under these special conditions will be determined. Experiments will be done first on lab scale and be up scaled to semi-farm level to prove their applied character. From these experiments derived data will be used to develop a bioenergetic model of processes within such systems.