RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Regeneration and zonation by ZEB2 of Liver Endothelium'.

assistant: **Concept**

The liver is a crucial organ in metabolism and removal of waste products from the body. Hereto, the liver parenchyma receives a mix of nutrient-rich blood from the portal vein and oxygen-rich blood from the hepatic artery. Blood flows through the sinusoids and leaves the liver via the central and hepatic veins. Hepatic sinusoids are highly specialised channels in which hepatocytes are organised in zones according to their position relative to the portal and central veins. They are lined with a specified, fenestrated, discontinuous endothelium. Many drugs (e.g., chemotherapeutics) and toxins cause damage to the sinusoids that may lead to liver fibrosis and cirrhosis. Formation of new sinusoids is an indispensible step for liver regeneration. Furthermore, liver sinusoidal endothelial cells (LSECs) produce agents that stimulate hepatocyte proliferation. Time-dependent expression of different proteins in the developing liver is important for sinusoid formation. The host lab found that the transcription factor Zeb2 (also known as Sip1) is highly expressed in LSECs in the developing and adult liver. Furthermore, its expression in adult LSECs is mainly in those from the pericentral zone. We hypothesize that Zeb2 is a transcriptional determinant of LSEC specification, zonation, maintenance and regeneration. Here, we aim to: (i) evaluate whether/how Zeb2 contributes to LSEC specification and zonation; (ii) establish a role for Zeb2 in LSECs in adult mice; (iii) assess its role in sinusoidal regeneration during liver disease; and (iv) estimate the therapeutic potential of Zeb2-treated endothelial progenitors in recovery from liver injury. To address these aims, we will use a multidisciplinary approach based on lentiviral overexpression in cultured ECs, transgenic mice lacking or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Sastravid - a new paradigm for the study of Indian philosophical texts' (SV-RT), addressing dissemination and exploitation.

assistant: **Impact**

The aim of the present project is to transform the way Indian philosophical texts are currently studied. To do this we provide a philosophical analysis of a set of central works from the Indian tradition, a set well known for its demanding content and the conceptual complexity of the arguments it contains. This analysis will incorporate a set of cutting-edge methodological principles, the most important of which is the intricate interlinking of conceptual analysis and its textual basis. These principles will be encoded in a web-based electronic tool that will be developed during the course of the project. This tool, called Sastravid, incorporates an example of the new research paradigm and at the same time facilitates further academic research based on the same approach. Its aim is to provide a key that unlocks the contents of Indian philosophical texts by bringing together the information contained in commentarial works, both ancient and modern, in a way that makes it easily accessible from the text itself. Apart from structuring the works, providing commentarial background and linking texts to other texts the present project develops a radically new way of analyzing the text's conceptual contents. This analysis is linked directly to the texts themselves, which makes it easy to switch between philological and philosophical modes of research. This linkage between conceptual and textual analysis embodies a radically new way of thinking about Indian philosophical texts that is located at the very frontier of the discipline and has never been applied to the study of philosophical texts before. It pushes the study of Indian philosophical works beyond the domain of mere textual scholarship into the emerging field of research studying Indian philosophy as philosophy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Decoding Cellular Memory: Exploring the Consequences of Cell Proliferation Over Time'.

assistant: **Objectives**

Maintaining cell identity is crucial for multicellular organisms; yet this “cellular memory” is potentially compromised each time a cell divides. To date, the degree to which sustained proliferation contributes to the accumulation of epigenetic and transcriptional errors over time, and to aging per se, is largely unknown. In DECODEM, I aim to analyse cell divisions uncoupled from chronological time, to gain unique insight into the cellular mechanisms underlying aging.We will investigate the extent to which a cell’s proliferative history determines its biological age. We will focus on the heterogeneous pool of muscle stem cells (MuSCs), to determine i) the links between the maintenance or loss of proliferative ability of individual MuSCs; ii) the accumulation of epigenetic and transcriptional alterations in different proliferative contexts; iii) the impact of replicative histories on the function of individual cells; and iv) the potential for blocking or reversing proliferation-associated alterations.DECODEM has the potential to reveal the fundamental rules that govern the degradation of transcriptional and epigenetic programs over replicative and chronological time. By advancing our understanding of aging and identifying alterations linked to degraded cell identity, this research holds the potential to contribute to regenerative therapies and to open new avenues for treating age-related diseases.


**Keywords:** CRISPR barcoding; cell identity; epigenetics; aging; proliferation; single-cell multiomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Regulation of (ADP-ribosyl)ation signalling in the DNA damage response: elucidating the function of a novel PARP1/ARTD1 interactor' to be submitted under Horizon 2020.

assistant: **Abstract**

(ADP-ribosyl)ation is a dynamic post-translational modification synthesised by PARPs/ARTDs and regulates a diverse array of cellular processes, including the DNA damage response (DDR). The last decade has significantly improved our understanding of the key enzymes involved in (ADP-ribosyl)ation and the cellular pathways they function within. However, our understanding of how these enzymes are regulated is lacking and demands further investigation. In this proposal I seek to redress this.I have provided promising preliminary data identifying a novel uncharacterised interactor of PARP1 involved in the DDR. I expect that this novel protein will have a fundamental role in PARP1 biology in cells given that the two have co-evolved and form a protein complex in cells. I will implement newly available cutting-edge technologies, such as CRISPR-Cas9 and quantitative cell biology approaches, into an interdisciplinary strategy involving genetics, cell biology, structural biology and biochemistry. This strategy will allow me to address the following research objectives: (1) elucidate the function of this protein complex in genome maintenance (2) determine the atomic structure of the complex (3) define the physiological function of the protein complex using genetic mouse models.This timely and holistic approach will allow me to answer crucial outstanding questions related to the regulation of (ADP-ribosyl)ation signalling for the first time. Consequently, this will be the first mechanistic study of its function and therefore my research objectives are likely to yield original insights into novel aspects of (ADP-ribosyl)ation signalling.The objectives described in this proposal will enhance my potential to become an independent investigator by promoting the diversification of my techn
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implementation of architectured real time systems using the vehicle area network', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

REALNET is a 24 month project dealing with the CAN protocol which became a Pan-European standard and is likely to be applied throughout the world. The white book of the OMI defines multiplex technology as being of highest priority. This is because the technology sees emerging markets and is key to consolidate the world class position of the European auto manufacturers. More than 13 million vehicles are produced in Europe every year. An increasing value of electronics is driven into these cars due to the application of multiplex technology. For the car manufacturer multiplex has significant advantages as it reduces the wire harness cost and allows the implementation of consumer visible distinguishing features. The European Module Library ELI does not contain any automotive multiplexing cells yet. Throughout the REALNET project a communication cell implementing the CAN protocol will be added to the European module library ELI. The integration of the cell with a CMOS microcontroller will be demonstrated. An extensive test and validation plan will be made an integral part of the ELI representation of the cell, such that the correct implementation of the CAN protocol can be ensured in future applications. Beside the implementation and exploitation of the CAN cell, an engine management demonstrator will be built in order to develop, integrate and demonstrate all aspects of a modern networked system. It will be top-down architectured and will apply an OSEK conformant operating system. The project consortium mirrors the vertical integration of the REALNET project: Dassault Electronique is involved in professional software development and has an excellent background on the validation of the VAN protocol; Motorola is a leading supplier of integrated circuits for the European auto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Innovative software tools for reliability centered maintenance management'.

assistant: **Innovation**

Objectives and content The main objective of this project is the development, setting-up and validation of an innovative methodology based on reliability and cost criteria, which, by its application to the improvement of the maintenance planning of equipments, allows to reduce the economic losses and to improve its availability. In consideration of its characteristics, the same results may be also obtained using the methodology for the improvement of the conception, project planning and construction of the components and equipments when this type of intervention is suggested by the experience feedback obtained on the basis of the calculated reliability and of a suitable use of the system analysis code. To meet these objectives, the project provides the setting-up of the computer methods constituting the methodology (a data bank for the storing of historical data, computer methods for the processing of reliability data on their basis, a computer method for the preliminary definition of the maintenance strategies and a Montecarlo reliability computer program for the system analysis) and its validation by a systematic application carried-out for two years on existing complex systems (transport systems, production industries, power production plants and telecommunication networks) directly managed by the partners who perform this activity. The validation will be an essential activity of the project which allows to obtain the sting of the methodology, its acquisition by the installations to which it is applied and, mainly, the demonstration that the prefixed objectives may be achieved by its application. To this aim, at the end of the project, savings in the costs and unavailability will be effectively measured by the quantification of direct and indirect factors such as gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Sustainable, High-throughput, Industry-ready, Next-generation technology for European manufacturing leadership in PV' (2021-2027) under Horizon Europe.

assistant: **Objectives**

SHINE PV will develop alternative technological routes to PV production for Silicon Heterojunction and TOPCon solar cells, covering the three key steps in the back-end manufacturing: metallization, post-processing and interconnection. SHINE PV will demonstrate different flows and down-select the most promising ones in terms of cost of ownership and high volume manufacturing readiness. Advanced equipment at TRL7 with Industry 4.0 dedicated features, innovative materials and solutions will be developed.For the metallization, SHINE PV will introduce parallel dispensing and plating as High Volume Manufacturing (HVM) alternative processes to incumbent screen printing, with the objective of demonstrating the complete or partial replacement of Ag with Cu, a fundamental step to enable Tera-Watt scale production levels.Moreover, SHINE PV will increase the efficiency through cell post-processing by applying Light Soaking process in HVM and recover the cutting-induced losses by Edge Re-Passivation. For the module making step, the innovations in interconnection proposed  are Twill and Shingling processes and HVM equipment. Both will leverage on the optimization of the metallization and post-processing steps and will demonstrate their potential in terms of superior electrical properties, aesthetics, reliability, and compatibility with premium module designs.The expectation of the project is to enable an increase of solar cell (or module) efficiency of 0.5% absolute versus the reference process with a simultaneous CoO reduction of 20%, due to reduced material costs and increased equipment productivity.SHINE PV project will demonstrate the integrated innovative processes and novel equipment both virtually and within physical pilots at industrial partners at TRL7. To our knowledge for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Freight delivery rationalisation in cities'.

assistant: **Objectives**

The economic shift towards service activity in urban areas will change the nature of transport in these areas more and more to delivery traffic rather than transit traffic. The increase of e-commerce and other expected changes in shopping behaviour are likely to accelerate this change of freight transport to more frequent deliveries, smaller parcels, more stops so a heavier influence on urban circulation. This calls for a highly efficient and widely supported policy to avoid an increase of mobility problems. Local decision makers and the automotive industry decided to join forces and build a joint vision between them and all other stakeholders. Based on this vision, they then will identify the R&D needs on organisational, technical, political, logistical and industrial level.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'PAGITA - The platform digitizing the world of vending machines' (PAGITA).

assistant: **Innovation**

The main objective of PAGITA is to let European customers paying purchases on vending machines by using a virtual wallet, without need of cash.The European Vending Market had a total revenue in 2015 of €14.6 billion Euros , in Europe, vending machines sell over 90 million food and drink items every day. Over 80% of machines are located in the workplace. The automatic vending market has high operating costs due to cash management and theft. A large portion of vending machines are “unintelligent”, they do not communicate any info on current stock and they do not enable optimization for logistics. Vending operators cannotcollect any information on their customers and their purchasing patterns. The increasing consumer preference toward cashless payments is a favourable trend observed in the market. The acceptance of payments through technologies, such as Near-field Communication (NFC), is instrumental in driving public interest owing to the easier, faster, and contactless modes of paymentPagita is a mobile commerce platform which allows customers to make quick and easy purchases from vending machines with an user friendly App. The platform is composed of an hardware module to be installed on the existing vending machines, a mobile app for consumers, and a cloud application for service management.After having tested its solution in Italian market (the main European market as per number of Vending machines), PAGITA is now addressing the European market, and it is targeting 23.000.000 turnover by 2020. The SME instrument Phase 1 will have the purpose to provide PAGITA with the knowledge needed to assess the technical and market feasibility of the project and to design a business and marketing plan that may support successful distribution of the service in the addressed markets
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Research Infrastructures: Foresight and Impact' (RIFI).

assistant: **Innovation**

The RIFI objectives are: - to create a methodology for evaluation of the socio-economic impact of investments in RIs, - to test and improve the elaborated methodology based on its application to several case studies in Romania and Bulgaria (at all the three levels of investment: pan European, regional and national), - to complement the methodology through integrating foresight, and to elaborate on the role of foresight for identifying RI investment opportunities. The RIFI methodological tool is especially important for the new EU member states, the remote islands of EU, and other countries with similar profiles with Romania and Bulgaria (e.g. from the Black Sea Region). The methodology will be a powerfull decision tool both for developing and adjusting the European policies related to RIs, and for pre-assement of certain RI investments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Future Internet Applied to Public Safety in Smart Cities' under Seventh Framework.

assistant: **Concept**

Safecity deals with smart Public safety and security in cities. The main objective is to enhance the role of Future Internet in ensuring people feel safe in their surroundings at time that their surroundings are protected.Safecity is the result of the elaboration of  a vertical Use Case Scenario based on Public Safety in European cities. The main goal of this project is to collect specific requirements driven by relevant users on the Future of Internet versus to the generic ones that will be collected through other objectives.The methodology follow to achieve this goal is as follow:1.\tThe definition of specific scenarios with the finality to negotiate with available infrastructures to support Safecity functionality, considering the involvement of main cities in Europe as Madrid, Helsinki, Athens, Bucharest, Stockholm etc along others. An Experts Committee integrated by other relevant European cities and Public Safety agencies will support this project.2.\tCollection of specific enablers, technical and functional requirements on the Future Internet in relation with Public Safety in contraposition of the generic ones and how the business process may be supported.3.\tElaboration of a conceptual Safecity prototypes and early trials in order to study the feasibility of this initiative. The demonstration of the concept will be carried out in Madrid as main city but other specific requirements will be demonstrated in a second city as Stockholm due to the contrast with Madrid.4.\tA strong liaison with other FI-PPP use cases and the FI Core Platform will be essential to the success of the project. For that, Safecity will support the FI-PPP Essential Interworking programme governance and activities that will ensure the integration of the Project activities across the whole progr