RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Building blOcks for iOdine thruSTer' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In the last decade, SmallSats (mass <500 kg) disrupted the space market since they allow to access space at a markedly lower cost with respect to medium-to-large systems, and this trend is expected to further grow in the next years. Solid iodine propellant has proven to be an enabling technology to consolidate electric propulsion (EP) in the SmallSat market. Nonetheless, its widespread diffusion is still hindered by issues related to the low maturity of this technology. In order to establish the groundwork for a future standardization and industrialization of iodine-based EP, a modular approach will be pursued in the frame of the BOOST project. Different EP building blocks suitable for different types of thrusters (Grid Ion Thruster GIT, Hall Effect Thruster HET) will be developed and assembled reaching TRL 5/6. A neutralizer based on an optimized RF cathode will be designed such as to be compatible with iodine propellant. A fluidic subsystem conceived for iodine propellant will be upgraded and adapted to the system. Moreover, a tank will be developed in optic of on-orbit servicing. In particular, a smart recharging system will be conceived with cartridges of solid propellant that can be stored into the tank during thruster operations. When the cartridge is completely exhausted it shall be extracted and substituted with a new one by a servicing spacecraft. Once every sub-system is completed and preliminary tested, the overall system shall be integrated for the final verifications. The outcomes of the BOOST project shall not only contribute to paving the way to a future standardization and industrialization of several electric propulsion building blocks but will also lead to a stronger space capacity in Europe, making it more attracting to the international stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Safety of progestins in hormone replacement therapy: Molecular mechanism and clinical application' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Objectives:To study the molecular basis of estrogen and progestin regulation of cell proliferation in uterus- and mammary gland.To develop cell/tissue culture and transgenic (knock-out") animal models for studying the action of sex steroids and for testing new progestins.To study the biological properties of new synthetic progestins for their suitability for HRT.Brief description:The major benefits and potential risks of long term progestin therapy are associated with their ability to regulate cell proliferation in the uterus and the mammary gland. Thus, it is important to learn what are true progestin effects in these organs as well as what are the combinatory effects of estrogens and progestins. The effects of long term progestine treatment on the uterus will be studied in women receiving progestin therapy. The effects of short- and long-term estrogen and progestin administration will be studied in more detail by using experimental animals and the molecular basis of these effects will be studied in vitro in mammary gland- and uterus-derived cell lines and explant cultures. These studies aim to unravel the mechanism of the effects of estrogen and progestins in the uterus and the mammary gland. In addition, a development of a transgenic (gene "knock out") model for testing new progestins has been started. These mice express only one of the two progesterone receptor isoforms and will serve as models to study different and sometimes opposite effects of some synthetic progestins through these two different receptor isoforms. New progestins aiming at the establishment of progestins with narrow tissue specificity will be characterised in multiple in vitro and in vivo approaches. The aim will be a development of new tissue specific progestins which can oppose estrogen induced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Environmental risk assessment of veterinary medicines in sludge' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Problems to be solvedVeterinary medicines are widely used across Europe and are released to land either directly or indirectly through the application of sludge. The medicines may persist and have the potential to runoff to surface water or leach to groundwater where they could impact human and environmental health. Under EU Directive 81/852/EEC, an environmental risk assessment is required on certain veterinary medicines. However, unlike other classes of chemical (e.g. pesticides, nutrients and industrial chemicals) the environmental impact of veterinary medicines is poorly understood. Consequently current risk assessment procedures are simple and have been developed to predict 'worst case' concentrations. Moreover, the approaches have not been validated. There is therefore a need to generate data on the behaviour of a range of veterinary medicines in the environment in order to develop an improved understanding of those factors and processes that affect their fate and to refine and validate current risk assessment approaches. This study, which will combine laboratory, semi-field, field and modelling studies, will investigate sorption, degradability, ultimate fate and ecotoxicity of a range of veterinary medicines. On the basis of the studies rules, models and experimental approaches will be recommended for the assessment of veterinary medicines that will be used in the EU in the future. A range of scenarios will be developed to assess the risk of veterinary medicines across Europe and finally, a tiered approach will be developed for use by industry and regulators involved in assessing the environmental risk of veterinary medicines.Scientific objectives and approachThe overall objective of the project is to develop approaches for assessing the environmental impact of v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Near infrared spectrophotometry and imaging for non-invasive functional assessment of biological tissue' under Fourth Framework.

assistant: **Concept**

The scientific objectives include achievement of quantitative spectroscopy by developing an advanced European Near Infrared Spectroscopy instrument, designed to meet the requirements of the clinicians. and improve and validate image reconstruction algorithms and improve data acquisition techniques as a first step towards neonatal brain functional imaging.The current CA programme will terminate on 31 December 1995 after establishing a solid base for a shared cost programme. This proposal for the Biomed 2 programme for the period Jan 96 to June 97 has a number of clearly defined objectives. One of the key objectives is the achievement of quantitative spectroscopy by developing an advanced European near infrared spectroscopy instrument. The objectives also include methods and techniques to improve and expand the accuracy of NIRS data and will include determinations of absorption and scattering properties of tissue. Measurement of CBV and CBF will be further refined and spatial localisation available from NIRS will be assessed. Muscle function will be evaluated by combining NIRS and MRS.The FEM models developed during the existing CA programme show good agreement but in order to guarantee a satisfactory behaviour in clinical applications the FEM model has to be validated against experimental data. Both the forward and inverse (reconstruction) models will be validated. The data acquisition time from phantoms as well as from biological tissue needs to be substantially reduced, for functional imaging and an automated data collection system will be developed. In parallel with this work tissue equivalent imaging phantoms representative of the neonatal brain and breast will be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Synthesis of receptors with nanosize cavities. Transducion of molecular recognition into electronic signals', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Almost from the beginning supramolecular chemistry has been associated with possible applications based on shape-selective interaction between molecules or between ions and molecules. These applications involve the translation of molecular properties to macroscopic level and will lead to new materials or devices. The real challenge is find ways to communicate with individual molecules or assemblies of molecules and exploit events at the molecular level. Molecular electronics, wires, switches, etc., have been discussed and nanostructures already approach this level. The objective of this project is the construction of three-dimensional architectures" with large, (semi-) rigid cavities (nanosize cavities). In rigid cavities, complexation is often difficult. Therefore the influence of some flexibility and/ or additional binding sites will be studied in order to obtain optimal complexation. One of the application of these molecules will be to perform (and accelerate) reactions (e.g. Diels Alder) inside of the cavities. Another particular challenge will be the application of these molecules as a possible chemical sensor. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Hungarian Night for Researchers 2011- Hungary-EU Research Careers' under Seventh Framework.

assistant: **Concept**

The protagonists of the 2012 RN will be researchers and the focus of the event will be on their public recognition. We will make a special effort to provide opportunities for both the public and the researchers to learn and think outside the box and present the truth that are behind stereotypes.Researchers will be at the center of all the individual programmes and of the awareness raising activities throughout the project demonstrating that they are ordinary, everyday people in their private life besides having an extraordinary career. During the event, they will show the audience all aspects of their talent (personal or science related) by linking science and other fields of their talent and personal interest. Many programmes will introduce researchers in an unexpected way – through their hobbies, through their private activities or personal engagements, emphasizing their “lay” character,  we plan to interlink researchers’ personal and scientific life in an enjoyable way.  We will follow a welcome in and go out approach. This means that we will welcome the audience at the researchers’ workplace, letting a glance into a world otherwise closed and “secret” to lay people (labs, and other research facilities), and at the same time researchers will appear in public places they are not expected to turn up otherwise in their researchers coats such as city centers, main squares and streets of the participating towns, community and exhibition centers, music halls, theatres and schools. Parallel with this we wish to show people that this scientific environment can be an entertaining place when researchers choose it to be. On the other hand ordinary everyday places such as town squares and streets, public buildings and restaurants, exhibition centres and sport fields can become p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Ubiquitous Pharmacogenomics (U-PGx): Making actionable pharmacogenomic data and effective treatment optimization accessible to every European citizen' (U-PGx), addressing dissemination and exploitation.

assistant: **Impact**

Pharmacogenomics is the study of genetic variability affecting an individual’s response to a drug. Its use allows personalized medicine and reduction in ‘trial and error’ prescribing leading to more efficacious, safer and cost-effective drug therapy.  The U-PGx consortium will investigate a pre-emptive genotyping approach (that is: multiple pharmacogenomic variants are collected prospectively and embedded into the patients’ electronic record) of a panel of important pharmacogenomic variants as a new model of personalised medicine. To meet this goal we combine existing pharmacogenomics guidelines and novel health IT solutions. Implementation will be conducted at a large scale in seven existing European health care environments and accounts for the diversity in health system organisations and settings.  Feasibility, health outcome and cost-effectiveness will be investigated. We will formulate European strategies for improving clinical implementation of pharmacogenomics based on the findings of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Characterization of the Human Gallbladder Microbiome' in the context of a Horizon 2020 call.

assistant: **Objectives**

The human gastrointestinal tract harbors a complex community of microorganisms that confer metabolic, immunological and neurological benefits to the host. This assemblage is known as the Gut Microbiome and has received increased attention over the last decade. Scientists have begun to uncover the importance of these bacterial inhabitants and expand investigations to consider how site-specific microbiomes affect host physiology. While more than one million cholecystectomies (gallbladder removal surgeries) are performed throughout Europe each year, the bacterial communities associated with the human gallbladder and its disease states remain unknown. Studies are lacking that characterize the effects of cholecystectomies on the gut microbiome. Without the ability to regulate bile entering the duodenum during food intake, it is expected that gallbladder removal will lead to downstream changes in the intestinal population. Here, the microbial composition of human bile, gallbladder mucosa, and biopsies of surgically removed healthy gallbladders (adherent and non-adherent microbiota) will be investigated using 16S rRNA metagenomics. The profiles will be compared to samples of a second cohort undergoing emergency cholecystectomies, in order to identify possible biomarkers for gallbladder disease. Once the gallbladder microbiome has been elucidated, the impact of its removal on the gut microbiome will be assessed. Using molecular and cultivation based techniques, on stool samples (collected during the recovery period) and analyzed for community composition, metabolomics, bile, fat and energy content. GallBiome will form the basis for establishing relationships between gallbladder microbiota, gut microbiota, and human health with a view to informing future development of diagnosti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'InnoGuard: Hybrid and Generative Intelligence for Trustworthy Autonomous Cyber-Physical Systems' (InnoGuard).

assistant: **Concept**

InnoGuard addresses novel challenges imposed by quality assurance of Autonomous Cyber-Physical Systems (ACPS), which have integrated Artificial Intelligence (AI) components. Their use in our daily lives is increasing, such as in public transport systems, highlighting the need for novel, robust development methodologies to ensure their dependability, whose compromise could have severe consequences, as exemplified by various incidents (e.g., accidents caused by Tesla's autopilot system). To ensure ACP dependability,  InnoGuard targets developing novel methods for ACPS quality assurance by creating a tailored training program for Early-Stage Researchers (ESRs), with scientific objectives including methods to automate ACPS quality assessment and behavior evolution using AI techniques and enhancing ACPS dependability through real-time security, privacy, and uncertainty handling solutions. Additionally, InnoGuard seeks to improve the trustworthiness of AI methods, enhance environmental sustainability by increasing the energy efficiency of ACPSs with the usage of AI methods, including Large Language Models (LLMs), and validate such techniques in open-source contexts such as Robot Operating Systems (ROS)-based systems. Ultimately, InnoGuard will deliver novel techniques and methodological principles for ACPS quality assurance, ensuring high trustworthiness, reliability, and legal compliance. The project's holistic approach encompasses technical advancements and training initiatives, with a broad plan to disseminate results to industry stakeholders, associations, and the wider public. Through these efforts, InnoGuard strives to elevate the status of ESRs as future experts in ACPS engineering.


**Keywords:** AI-Enabled Cyber-Physical Systems,  Quality Assurance,  Large Language
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Minutiae template interoperability testing' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

As biometrics are adopted more broadly interoperability and security of biometrics becomes increasingly important.The EC has specific requirements to use fingerprints for future visas, non-resident permits formats, passports and travel documents. Consequently there is an urgent need to test and improve the interoperability of fingerprint biometrics.Traditionally interchange of fingerprint data has used the fingerprint image, but data sizes make this inefficient compared to the minutiae template used by most fingerprint systems. The use of minutiae based templates enables solutions to be more privacy sensitive, as the template can be stored on the simplest of smart cards, rather than having to be stored in a central database.MIT brings together key players with all the required expertise to deliver strategic research targeted at testing and improving the interoperability of minutiae-based fingerprint systems within a timescale to meet the needs of EU policy legislation.The project takes as its starting point the existing work on fingerprint minutiae data interchange standards, the problems of interoperability identified in the recent test for the seafarers ID card, and the current NIST benchmark of minutiae interoperability, and will extend this existing work to improve the standards, the test methods and the interoperability of fingerprint minutiae systems.MIT will- define criteria for interoperability and interoperability testing- develop a database of fingerprint images to enable testing,- develop a testbed enabling the automated and repeatable testing of fingerprint minutiae interoperability, and also investigation of how factors such as image quality are important for interoperability,- incorporate an improvement step, whereby the interoperability of the tested syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'REpurposing lung Surfactant Protein B for Inhalation therapy with RNA therapeutics' (RESPIRNA).

assistant: **Concept**

RESPIRNA aims to repurpose lung surfactant protein B (SP-B) to promote the cytosolic delivery of RNA in lung-related target cells. RNA therapeutics, including small interfering RNA (siRNA) and messenger RNA (mRNA), are poised to revolutionize medicine. However, despite a clear unmet medical need in many lung diseases, no RNA formulations are currently available for pulmonary administration. To unlock the full therapeutic potential of RNA drugs, safe and efficient nanomedicines that can deliver them inside target cells are required. SP-B is a key component of pulmonary surfactant, essential for mammalian breathing. In contrast to the general belief that pulmonary surfactant constitutes an important extracellular barrier for macromolecular drug delivery in the lung, I recently discovered a previously unknown property of SP-B in its ability to promote transmembrane delivery of RNA inside cells. Here, I aim to repurpose this biomaterial for intracellular RNA delivery, (1) by exploring SP-B's cellular mode-of-action towards improved cytosolic delivery of RNA, (2) by designing multifunctional and multicomponent lung surfactant nanocarriers and (3) by applying these nanocarriers for RNA delivery in the lung, using models of obstructive lung disease.Gaining mechanistic insight into how an endogenous membrane-active protein like SP-B can mediate cytosolic RNA delivery will allow me to maximize SP-B mediated delivery of promising RNA therapeutics and will fuel rational design of lung surfactant inspired nanocarriers for inhalation therapy. Beyond RESPIRNA, I anticipate that such nanocarriers will be more generically applicable for a wider variety of membrane-impermeable drugs, nanomedicines and pathologies.


**Keywords:** nanomedicine, RNA therapeutics, inhalation therapy, endos