RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional characterization of FAN1, a structure-specific DNA repair nuclease' under Seventh Framework.

assistant: **Concept**

DNA interstrand crosslinks (ICLs) are toxic lesions, which prevent the separation of strands necessary for DNA replication. ICLs arise in cells when common endogenous metabolites react with DNA and when cells are exposed to commonly used chemotherapeutic drugs, such as mitomycin-C (MMC) and cisplatin. Defects in the repair of endogenous ICLs cause Fanconi anaemia, characterized by chromosome instability and cancer predisposition, which underscores the importance of ICL repair for human health. In 2010, several groups reported the identification of Fan1, a structure-specific nuclease that is required for ICL repair, but the underlying mechanisms are unclear and little is known about how Fan1 promotes DNA repair. Recently, it was reported that Fan1 mutations in humans cause karyomegalic interstitial nephritis (KIN), which is characterized by degeneration of organs including kidney. This may reflect premature aging of organs caused by unrepaired DNA damage. The lab in which I will carry out the proposed studies is generating Fan1K975A/K975A knock-in mice, which express a nuclease-inactive form of Fan1. I will study these mice in detail to test the consequences of Fan1 inactivation at the level of cell and organism. I am particularly interested in testing for a Fanconi anaemia-like phenotype and/or progeria. Cells from the Fan1-defective mice will be used to determine the role of Fan1 in ICL repair. There are several nucleases other than Fan1 required for ICL repair, such as Mus81-Eme1 and Slx1. I will also test the relationship between Fan1 these factors by making mouse defective in Fan1 and each of these factors. Finally I aim to study the regulation of Fan1 function by phosphorylation. These experiments will provide valuable insight into Fan1 function, and the project wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Hunting Invisibles: Dark sectors, Dark matter and Neutrinos'.

assistant: **Objectives**

Despite huge progress in particle physics and cosmology, most of the Universe’s building blocks and how they function remain hidden to us: Neutrinos are the most abundant known fermion but the reasons why they have mass and mix are unexplained; we have evidence of Dark Matter but we do not even know which particle makes it up;  particles and antiparticles show to behave differently (the so-called CP-violation) without a compelling reason; we see that in the Universe there is mostly matter and very little antimatter, but we do not know why this is the case. Symmetries and their breaking will be the guiding principle to address those questions. HIDDeN will focus on revealing the (a)symmetries we have yet to discover, hence hidden (a)symmetries, and the particles on which they act, in particular the invisible sector, made of neutrinos, dark matter and other elusive particles. We will explore simultaneously the puzzles related to the CP symmetry in the lepton sector as well as in strong-interactions (the latter leading to axions and axion-like particles), (a)symmetries in the mass and mixing patterns of known particles, (a)symmetries responsible for the dark matter stability and its interactions. And we will address a key question: are all these sectors part of a new HIDDeN sector whose discovery will lead us to the New Standard Model? The mission of the HIDDeN ITN is to train the new generation of researchers to address these most fundamental questions via an ambitious multidisciplinary research and training program. We focus on phenomenological studies and include crucial links to experiments and industrial partners. We bundle world leadership in phenomenology research and our network includes representatives of key-experiments and laboratories on the field, such as CERN,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Industrialization and commercialization of mass production processes for the texturing during moulding of dynamic seals in order to increase industrial equipment energy efficiency and durability'.

assistant: **Concept**

Softslide project's main objective is to generate €60 M revenue, an EBIDTA of €19,9M and 350 new jobs with the commercialization of SoftSlide's technology estimated from a conservative sub-market share of 15% of the total elastomeric and plastic dynamic seals European market. SoftSlide technology will positively impact the seal industry by providing around €3315 M/year in energy savings for hydraulic and pneumatic end-users. Energy losses caused by friction within dynamic seals in rotating, moving and reciprocating devices (e.g. motors, valves, air compressors, accumulators...) represent up to 25% of total energy consumption. In addition, dynamic seals related friction, damages the seal surface overtime, thus reducing its lifetime. Although, it is of common knowledge that low-friction dynamic seals can be obtained by specifically designing and engraving micro-patterns on the seal contact area (area in contact with the moving mechanism), current seals' mass production processes do not incorporate this crucial step. To get a low-friction dynamic seal, the micro-pattern needs to be individually engraved, seal by seal at an independent later stage, once the seal has been produced. This greatly increases the cost and limits the productivity of low-friction dynamic seals being impossible for end-users to include these in their systems. SoftSlide project has created a mass production process that transfers micro-patterns during moulding stage to obtain low-friction, high performing dynamic seals. This process can be easily adopted by dynamic seals manufacturers seals with an insignificant cost increase.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Ethnic Conflict, Cross-Community Practices & Transversal Assemblages'.

assistant: **Concept**

The research aims at the elaboration of a philosophy of transformative action for ethnically segregated, conflict-ridden societies, in order to explain the challenge posed by existing practices of cross-community cooperation. This new approach to ethnic conflict draws on the tradition of transversal critical thought and on Gilles Deleuze & Félix Guattari’s (D&G) theory of assemblages. It focuses on the revitalisation of radical agency and conceives cross-community practices (CCPs), assembled by subjects (individuals and groups) and objects (cultural and spatial) in divided societies such as Northern Ireland, Israel, and Australia among others, as producing alternative political spaces by challenging segregated forms of life and actual power relations. Objectives: 1. To explore the concept of transversality in Western critical thought through the lens of ethno-cultural conflict: 1a. To examine the genealogy of transversality through the oeuvres of M. de Certeau, F. Guattari, G. Deleuze, and M. Foucault and of contemporaneous interpreters of the concept. 1b. To explore the articulation of the concept in these texts in relation to social struggles and in the context of divided societies. 1c. To articulate a revisited concept of transversality appropriate for the theorising of ethno-cultural conflict. 2. To explore the applicability of D&G’s theory of social assemblages for ethno-cultural conflict. 3. To place the notions of transversality and assemblage within the context of ethno-cultural conflict and the politics of segregation. 4. To connect between transversality, assemblage and the politics of CCPs in divided societies using existing published research on case-studies. 5. To assemble a theoretical framework for comparative analysis of CCPs in divided societies. This r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Technology Opportunities and Strategies towards Climate-friendly trAnsport' under Seventh Framework.

assistant: **Concept**

The EU has committed to reducing GHG emissions by at least 20% based upon the 1990 level by 2020 and further reductions are expected beyond that timeframe.  However, realizing this and subsequent targets may become increasingly challenging, given the past growth and future projections of transportation GHG emissions.  The proposed activity enables the EU to obtain a better strategic perspective as to what contribution future transportation technologies and fuels could make to reduce GHG emissions.  The project presented here assesses the technical feasibility, economic affordability, and social acceptability of technology policies that would lead toward a lower climate-impact transport system within the EU under different scenario conditions.   The project is organized around three major workshops, which include important stakeholders from academia, industry, government, NGOs, and key participants from relevant existing and former EU projects.  In order to enable informed and focused discussions at each workshop, participants are provided with supporting studies well before each workshop.  The workshops and supporting studies cover (1) a techno-economic assessment of major transport modes (automobiles, buses, trucks, aircraft and railways) and of alternative transportation fuels for reducing GHG emissions; (2) an integration of these technologies in scenarios of European transportation futures; and (3) an estimate of the penetration of future low-GHG emission technologies and fuels for promising policies under the different scenario conditions, along with an assessment of the societal implications of these policies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Rotatory role-playing and role-models to enhance the research integrity culture' (Path2Integrity) targeting Horizon 2020.

assistant: **Abstract**

The Path2Integrity project is a two-component coordination and support action to enhance research integrity culture. Path2Integrity develops and fosters role-models and rotatory role-plays for adolescents. A Path2Integrity campaign on scientific facts about research integrity and role-models, raises awareness on research integrity within secondary schools and universities. Complementary a Path2Integrity handbook of instructions, which contains vivid stories on research integrity and rotatory role-playing as primary dialogical exercise increases students’ ability to reason on the acceptance or rejection of norms in research integrity. Partners from the Consortium have award-winning experience in creating those settings, which allows Path2Integrity to work with already in existence and successful educational practices.  Taking into account that different disciplines and different schools of thoughts are involved, the Consortium takes paramount importance, to ensure explicitly that the Path2Integrity handbook and campaign are based on optimal and systematic evidence-based decisions. Therefore, the key concept of the Consortium is the development of practical educational knowledge. The Consortium will train at least 150 disseminators in the consortiums countries and beyond, and additionally foster the campaign (fact sheets, infographics, flyers, posters, brochures) in at least 15 European countries to enable awareness-raising in different educational organizations (schools and universities).


**Keywords:** Innovative learning methods for research integrity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Receptor signalling in space and time - Gaining high-resolution information of the temporal and spatial control of  G protein-coupled receptor signalling.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

G protein-coupled receptors (GPCRs) are the largest family of cell surface signal transducing proteins encoded by thehuman genome. They allow the cell to respond to diverse array of extracellular signals, control most (patho)physiologicalprocesses, and are currently the therapeutic target of over 30% of marketed drugs. However, GPCR drug discovery is stillcharacterised by a very high attrition rate, which reflects our inadequate understanding of the complex mechanisms ofGPCR signalling and regulation.Up until recently, understanding of GPCR function was obtained from snapshots of receptors at different points in time and amajor limitation for the study of GPCRs has been the inability to assess receptor activation and subsequent signalling eventswith high temporal (duration and frequency) or spatial (location) resolution. However, in the recent years there has been anexplosion of biophysical and imaging approaches that will allow greater temporal and spatial resolution of receptor functionthan ever before. In this project we will measure ligand binding, receptor conformational changes, G protein activation,recruitment of regulatory proteins and receptor trafficking in real time and in live cells. We will therefore obtain detailedmechanistic understanding of the dynamics of GPCR activity in health and in disease that will reveal novel interventionpoints for future, more effective receptor-based therapies.This proposal combines my expertise in the study of GPCR interacting proteins and their role in receptor signalling andtrafficking with the expertise of the Host Institution in the application of state-of-the-art imaging and biophysical approachesto study of this receptor family. As such, this project will not only broaden my research and technical skills in GPCRvisualiza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Democratized Financial Services'.

assistant: **Concept**

BlockState is proposing efficient, transparent and compliant democratized financial services forthe financial market using Blockchain technology. DFS is translated through the following innovativeproducts which are driven by decentral IT solutions and connected together via a technology stack:CRYPTO15 (crypto index products), DETI (tokenized debt instrument) and DECEND (a platform for smartcontracts for illiquid derivatives). BlockState will be approaching exchange-traded funds, the bondsmarket, and the derivates market, all of which have experienced continuous growth, both in the EU andworldwide. End-users of the solution are private and institutional investors, to which DFS offers an efficientway to safely track top crypto assets (through CRYPTO15 CTF Token and CTF ETN), banks and otherlenders, for which it supports syndicated loan facility from origination to payoff (through the DETIplatform), and financial institutions, which are enabled by DFS to buy and sell derivatives on the blockchain(through the DECEND platform).BlockState is creating the technological and legal infrastructure for the future of investment banking,through a comprehensive set of investment banking modules based on Blockchain technology; ourproducts are more efficient than the current products creating cost savings, more transparent than thecurrent products reducing risk and fully compliant with the regulatory body and easily accessible.BlockState is a new generation of fintech, offering investment banking on a modular platform build onBlockchain technology. The company is building the world’s leading blockchain investment bank,specializing on DLT- based products for asset management, debt capital markers (DCM), and derivatives.BlockState’s products embody technological excellence, highest regula
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advancing the theory of photometric stereo for texture extraction' under Sixth Framework.

assistant: **Concept**

The main goals of the project are to advance the theory of photometric stereo, to develop new practical algorithms for robust photometric stereo, and to broaden the limits of photometric stereo applicability and accuracy for the specific case of surface te xture recovery. Surface texture is modelled as a composition of surface geometry (a bump map) and first-order reflectance characteristics (a Lambertian albedo map). This is why photometric stereo is selected as the method of interest, since it excels in re covery of these two entities. Its input is images acquired under a fixed viewpoint and changing illumination. The motivation for detailed photometric stereo analysis comes from three main points: 1. Applicability. It is usually assumed that the illuminatio n conditions used to acquire individual input images are known. If this is not the case, the output entities can be recovered only up to a global ambiguity containing nine degrees of freedom. Recent work by the applicant shows that when an ideal specular c omponent of reflectance is present, the ambiguity reduces to only two degrees of freedom. We intend to extend this result for more complex reflectance models. 2. Robustness. For high-quality results, common image phenomena such as specular interreflections , cast shadows, etc. must be accounted for, otherwise the results are biased. Such phenomena represent outliers to the assumed model of reflectance. We need to analyse the possibilities for fast and robust methods for their detection. 3. Accuracy. While Po int 2. addresses the phenomena that cause gross deviations of image intensities from the values predicted by a reflectance model, this point focuses on more tiny phenomena of diffuse interreflections in the concavities of a bump map. When the illumination is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Integrated Approaches for Sustainable Crop Production in Slovenia: Resisting Global Changes' (CROPSUSTAIN), addressing dissemination and exploitation.

assistant: **Impact**

Diverse consequences relating to inevitable climate changes including changed weather patterns and invasive species, globalization and the urgent need for the development of sustainable food production systems present enormous challenges for the agricultural sector. The need for sustainable, however, also sufficiently high agricultural production is primarily a scientific challenge because of insufficient knowledge of processes related to changing conditions and competing economic and environmental goals. The specific situation in Slovenia, characterized by overall small enterprises consisting of small fields or orchards in mainly hilly areas require the development of novel concepts for resisting global changes.CropSustaIn aims at significantly improving scientific research for the development of sustainable crop production and environmentally friendly plant protection strategies in Slovenia at changing climatic conditions. A key objective of the project is the creation of a new network integrating the Agricultural institute of Slovenia (KIS), through the collaboration of national and international research institutions, agricultural holdings and companies.Newly established links of KIS with leading European agricultural research institutions will provide access to foreign knowledge flanked with technological modernizations through CropSustaIn. The project therefore allows integration of Slovenia into the European Research Area.Implementation of CropSustaIn will be beneficial for the scientific and applied community in Slovenia dealing with plant health and also other European countries can profit from it. CropSustaIn enforces close collaboration between researchers at KIS and the industry and allows optimized result exploitations. Once the network is established it wi