RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Beta Cell Therapy in Diabetes'.

assistant: **Innovation**

Type 1 diabetes is a serious chronic disease with major health risks and heavy burden on patients and society. It is caused by massive immune-mediated loss of insulin-producing beta cells in the pancreas that can so far not be locally corrected. A cellular allotransplant in the liver can install a new beta cell mass but the size is insufficient and the procedure faces limitations of donor shortage, inaccessibility of the implants, risks of associated immunosuppression. Our consortium of research, clinical and bioindustry teams is focused on overcoming these obstacles and implementing a roadmap for translation to preclinical models and clinical trials. We will pursue three interacting tracks. First, our ability to induce beta cell progenitors and stimulate beta cell proliferation in vivo should lead us to cells and compounds that activate this process in a diabetic pancreas, thus activating endogenous beta cell regeneration. Second, we will produce human beta (progenitor) cells in vitro by derivation from stem cells as well as from reprogrammed autologous cells; their therapeutic potential will be compared to that of primary human beta cells following implantation in rodents using a site that is accessible to modulation and monitoring. Third, we will design an antibody-based therapy for inducing immune tolerance to regenerated beta cells and to a beta cell implant. Efficacy, safety and regulatory criteria will be determined for clinical implementation. Clinical protocols will be prepared by adjusting associated therapy and by adopting an accessible and controlled implant site. Clinical trials will benefit from state-of-the art biologic markers for comparative analysis of the developed forms of beta cell therapy. This program should provide proof of principle for strategi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening Ukraine and EU research cooperation in the field of Material Sciences' (SUCCESS).

assistant: **Concept**

The 36-months SUCCESS project is based on a twinning approach between one of the leading Ukrainian scientific and educational organisations, the Institute for Scintillation Materials of Academy of Science of Ukraine (ISMA), with their long term partner University Claude Bernard of Lyon (UCBL). The project gives Ukraine the possibility to improve the research activities of their highest quality in the FP7 thematic priority “Nanosciences, nanotechnologies, materials & new production technologies” (NMP), and in particular in the field of Material Sciences.SUCCESS include several main types of activities, thus forming a coherent plan for improving the ISMA’ capacities in a number of fields relevant to the FP7 Thematic Priority “NMP”:(1) Preparatory and analytical activities: preparation of ISMA Strategic Development Plan based on ISMA SWOT analysis and socio-economic analysis on Ukraine, Eastern Europe and EU level;(2) Twinning activities, based on the twinning and joint research plan to be prepared and implemented jointly by ISMA and UCBL, and linked to the Strategic Development Plan of ISMA. This activity includes, for example, exchange of researchers and young specialists, organisation of joint scientific workshops, set up of joint research experiments in EU, feasibility study of a joint virtual laboratory ISMA-UCBL and first implementation steps. Sustainability plan will be designed and implemented.(3) International cooperation activities, such as networking & brokerage, ETP and FP7 consortia integration etc, which will be implemented on wide European and regional level, involving other European organisations, thus extending the project impact.(4) Training and coaching activities, that will aim to increase the ISMA' understanding of FP7, build competences and enhance th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design against DISTortion of metallic aerospace parts based on combination of numeRical modelling ACTivities and topology optimisatION' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Thanks to the implementation of advanced CAD and topology optimisation, lighter and more efficient component designs can be conceived nowadays. However, current design tools and methodologies do not account for part distortions in manufacturing. Distortions are critical during prototyping and ramp up stages and they increase developing costs, times and generate wastes and scraps. Design against Distortion topic is focused on the development of numerical modelling strategies which can anticipate distortions even from the design stage. In this context, DISTRACTION project copes with the development and application of rapid distortion prediction numerical methodologies applicable to machining and additive layer manufacturing (ALM) of metallic parts and the development of concurrent topology optimisation codes capable of accounting for part distortion. Integration will be based on efficient adjoint sensitivities for simplified distortion prediction models. This will enable for first time to have optimised designs which are “ready-for-production” and robust against distortions. Developments will be applied to relevant use cases and will be based both on open source and commercial software. The following specific objectives are targeted:•A 30% weight reduction of fuselage component’s weight•Reduction of manufacturing costs of new fuselage parts by 20% •Reduction of time-to-market of new fuselage parts by 25%•Reduction of computational times by 30% for predicting distortions •Reducing scrap ratio of fuselage parts during prototyping and ramp up phases by 50%Consortium (IK4-LORTEK & TU-DELFT) of DISTRACTION proposal will have as reference internal know-how related to all previous developments in simplified Finite Element methodologies. The working group will be composed by skil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The influence of Environmental Variability On Mussel Aquaculture and adaptation in the context of global ocean change' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Global ocean change (GOC, including warming and acidification) poses one of the largest threats to marine fisheries and aquaculture. Yet, there are still few predictive consequences, due to the limited understanding of species’ in situ responses. Recent studies suggest that spatial differences in environmental conditions influence physiological tolerances of marine populations. This project tests the hypothesis that environmental variability of multiple stressors (temperature, pH, salinity) enhances physiological hardiness of sensitive early life-stages of an economically valuable mollusk, the mussel Mytilus galloprovincialis. The project implements a novel, three-pronged, multidisciplinary approach using (1) population comparisons to assess performance of mussels from sites of low and high environmental variability, (2) mild stress exposures to test for enhanced physiological performance in the field, and (3) larval cultures to assess proteomic responses to temporal variability of multiple stressors and carryover effects to juveniles. This project includes collection of oceanographic time-series data at field sites (including at an aquaculture farm), with state-of-the-art pH sensors, to identify frequency of stress events and inform experimental design. This still rare approach, using in situ data with laboratory studies, improves environmental realism in GOC studies. The project addresses a crucial gap in the current understanding of coastal environmental variability and multiple stressors and has direct application to aquaculture practices. By combining the researcher’s and host’s expertise on marine physiology related to GOC pressures, this project will advance innovations in the field of GOC biology, state-of-the-art pH sensor technology transfer, and applied prote
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The threat status of endemic Atlantic Forest trees' in the context of a Horizon 2020 call.

assistant: **Objectives**

One of the most drastic impacts of man on Earth is species extinctions. We do not know how many species are extinct and how many will go extinct, but we may be experiencing a sixth mass extinction. Thus, actions to help protect species from extinction are urgently needed. These actions should be prioritized in biomes such as tropical forests that shelter enormous biodiversity but have increasingly been impacted. One example is the Atlantic Forest in South America. It shelters around 5% of world species, half of them being endemic. But 86% of its original extent has already been lost and only about 1% is effectively protected. To support the protection of the Atlantic Forest, this proposal has the following goals: (i) to assess the threat status of endemic Atlantic Forest trees (EAFT) based on all criteria of the International Union for Conservation of Nature (IUCN), (ii) to quantify the evolutionary uniqueness of globally threatened EAFT, (iii) provide guidelines to conserve threatened EAFT, including the identification of gaps of knowledge and priority areas for their conservation, and (iv) to involve the local society in species conservation through the proposal of a citizen science program. The proposed action is perfectly aligned with targets of the United Nations Strategic Plan for Biodiversity 2011-2020, the Global Strategy for Plant Conservation 2011-2020 and the IUCN Global Tree Specialist Group. It is multi-disciplinary with both scientific and applied components. It combines large datasets with high-resolution maps, up-to-date modelling techniques and the expertises of researchers from four different countries. It will also provide new information that can be readily used by conservation agencies. Finally, it will engage different social actors to launch a con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D bioprinting of pancreatic tissue for biomedical research' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Developing therapies for pancreatic diseases, such as diabetes and pancreatic cancer, is hampered by a limited access to pancreatic tissue in vivo. Engineering three-dimensional (3D) tissue models, which accurately mimic the native organ, have great potential in biomedical applications, by both providing powerful platforms for studying tissue development and homeostasis and for modeling diseases in pharmaceutical testing. Our research proposal establishes a multi-disciplinary European consortium with the ambitious goal of developing an innovative bioprinting approach for generating pancreatic tissue. Tissues and organs comprise multiple cell types with specific biological functions that must be recapitulated in the printed tissue. We will biomimic developmental processes to fabricate 3D bioprinted pancreatic tissue units that allow sustained cell viability, expansion and functional differentiation ex vivo. Specifically, the aim of this proposal is three-fold: 1. To expand and unify the knowledge of 3D in vivo architecture of the developing pancreas; 2. To develop bioprinting technology for engineering vascularized pancreatic tissue units; and 3. To establish conditions for in vitro differentiation and maturation of the bioprinted pancreatic tissue.This exploratory research in the emerging technological field of bioprinting will pave the way towards new technological possibilities of growing functional tissues and organs in a laboratory. We expect that the knowledge and paradigms generated by our research project will not only drive major technological advances in tissue-engineering and bioprinting, but will also open radically new possibilities in medicine, allowing to study pancreatic diseases ex vivo in fabricated tissue, to develop new drugs, and, possibly to facilit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced versatile artificiaAdvanced versatile artificial intelligence technologies and interconnected cross-sectoral fully-operational national focal points for combating illicit firearms trafficking' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Ceasefire targets the development of a highly innovative, holistic, multi-disciplinary, high-tech and versatile approach for significantly increasing/broadening the operational capabilities of EU Law Enforcement Agencies (LEAs) in their struggle to detect, analyze and track cross-border illicit firearms trafficking related activities. In particular, Ceasefire efforts will concentrate on the following major driving axes: a) The development of advanced Artificial Intelligence (ΑΙ) technologies for significantly facilitating the everyday work of the involved practitioners, and b) The establishment of fully-operational National Focal Points (NFPs), by targeting to alleviate from current organizational, operational, cooperation, legal, cross-jurisdictional, trans-border and information exchange challenges. The former corresponds to a wide set of AI-enabled tools, including solutions for cyber patrolling, Web data gathering, on-the-spot detection of firearms, advanced Big Data analytics, cryptocurrency analysis, large-scale information fusion, visual analytics and firearms-related intelligence collection. On the other hand, particular attention will be given towards defining models, protocols and procedures for making NFPs fully functional, complemented by activities for mapping the various legal frameworks (within different countries) and procedures (within different agencies) for harmonizing investigations, cooperation, lawful evidence collection and forensics analysis. The development of efficient information sharing mechanisms among LEA (police, border guard, customs), judicial and forensics authorities will further reinforce the system capabilities. Moreover, the tasks of Ceasefire will complement the objectives and activities of the EU Policy Cycle (EMPACT) – Firearms (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Immediate and long-term health risks of excessive screen-based media use' (SCREENS).

assistant: **Concept**

Excessive screen-based media use in young people is a clear emerging public health concern which commands serious attention and research to keep pace with the fast and profound changes in technology of screen media and how it is used. The proposed research project’s overarching objective is to investigate the immediate and long-term effects of screen-based media use on a number of important health outcomes in young people. In work package (WP) 1 and WP2 we will investigate the short-term effect of limiting screen use and timing of limiting use on circadian rhythm, sleep, physical activity patterns, and mental stress in 7-year old children and among adolescents/young adults. The WP3 of the proposed project will develop and validate a parent- and self-reported questionnaire to assess time spent (and timing of use) on different forms- and content of today’s screen media among young people and adults. We will introduce these instruments in a number of large-scale population-based cohort-studies. One of the studies will include a large birth-cohort study, which is the basis for the WP4 sub-study. The 7- and 9-year wave of the birth cohort study will provide an ideal context to investigate the long-term influence of exposure to screen-based media on physical fitness, adiposity, glucose metabolism, and mental health in children. The project will integrate multidisciplinary research into the most thorough investigation to date of the plausible short- and long-term effects of screen-based media. Through rigorously conducted randomized crossover experiments and prospective observations in a birth cohort the present project proposal will leverage methodological development of screen use assessment and new technology advancements to assess physical activity patterns, circadian rhyt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Application relevant validation of c-Si based tandem solar cell processes with 30 % efficiency target'.

assistant: **Innovation**

Crystalline silicon wafer solar cells have been dominating the photovoltaic market so far due to the availability and stability of c-Si and the decades of Si technology development. However, without new ways to improve the conversion efficiencies further significant cost reductions will be difficult and the c-Si technology will not be able to maintain its dominant role. In the SiTaSol project we want to increase conversion efficiencies of c-Si solar cells to 30 % by combining it with III-V top absorbers. Such a tandem solar cell will result in huge savings of land area and material consumption for photovoltaic electricity generation and offers clear advantages compared to today’s products. The III-V/Si tandem cell with an active Si bottom junction with one front and back contact is a drop-in-replacement for today’s Si flat plate terrestrial PV. To make this technology cost competitive, the additional costs for the 2-5 µm Ga(In)AsP epitaxy and processing must remain below 1 €/wafer to enable module costs <0.5 €/Watt-peak. It is the intention of the SiTaSol project to evaluate processes which can meet this challenging cost target and to proof that such a solar cell can be produced in large scale. Key priorities are focused on the development of a new growth reactor with efficient use of the precursor gases, enhanced waste treatment, recycling of metals and low cost preparation of the c-Si growth substrate. High performance devices will be demonstrated in an industrial relevant environment. The project SiTaSol approaches these challenges with a strong industrial perspective and brings together some of the most well-known European partners in the field of Si PV and III-V compound semiconductors. Furthermore SiTaSol will support the competitiveness of the European industry b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Delivery of algae oil into vegan milk through novel O/W emulsions (nano-emulsion and Pickering emulsion) stabilized with seaweed peptides'.

assistant: **Concept**

Health benefits of oils rich in polyunsaturated fatty acids, such as algae oil, have surged researchers to find efficient ways to deliver these oxidation-prone oils into food products. One of the hottest areas in this regard is the incorporation of the oils in oil-in-water emulsions; however, the emulsions are physically and oxidatively unstable upon storage, leading to quality deterioration in the final product. The present study is thus an attempt to stabilize these delivery systems by reducing droplet sizes and forming the so-called nano-emulsions as well as taking such measures as the encapsulation of the oil and incorporation of antioxidant peptides from seaweeds. Another state-of-the-art measure is the use of bioactive peptides purified from seaweed in a complex with a cationic surfactant as Pickering particles to form stable PUFA-rich oil delivery systems. The emulsions, either in encapsulated or non-capsulated forms, will then be introduced into oat milk to produce marine oil-enriched vegan food. A unique characteristic of this research is that bioactive agents will be purified from Palmaria palmata, a seaweed found in Denmark, which can contribute to attaining sustainable development in food technology. In this sense, one of the most restricting obstacles to using natural peptides is their bitterness; the present study tries to reduce or ideally remove bitterness by electrospraying the emulsions containing these peptides. This interdisciplinary research will pave the way for prospective researchers to consider the possibility of delivering healthy oil into vegan societies’ food baskets through efficient means in a way that taste and odour of the final products are not sacrificed for this purpose. The gained expertise in the present project will provide great jo