RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Automated mini-invasive surgical approach to the treatment of mitral insufficiency' (MITrep), addressing dissemination and exploitation.

assistant: **Impact**

Mitral valve insufficiency is a heart condition, where blood is abnormally leaking out of the mitral valve. This condition mainly afflicts the elderly patients: -80% of patients aged 80+ show moderate symptoms (chronic fatigue, shortness of breath, palpitations, racing heart rate)-10% of patients above 75 with severe symptoms are at risk of a sudden death (stroke) within 5 years.-Prevalence will double by 2030.Mitral insufficiency is treated with open heart surgery (300,000 operations/year in the EU and the USA) followed by intensive care. But this operation is unbearable for fragile patients. Half of the patients above 75 are tagged inoperable because of their age. Less invasive repair surgeries have been tested (annuloplasty by transfemoral surgery) but lack efficiency and safety and require highly skilled surgeons (not available in each hospital).In this context, the company CMI’nov has developed MITrep, the first patented mini-invasive surgical device that automatically goes to the mitral valve with no trial and error to affix a leak-preventing ring on the valve.It uses the transapical approach. Once the ring is anchored, the mitral valve returns to normal activity. No heavy post-surgery effects are expected. No intensive care required.MITrep can be used by any surgeons : no need to be a mitral valve specialist. It will allow to halve the operation time (from 5 hours to less than 2 hours), reduce hospitalization time to 3 days (vs 5-8 days with 2 days in ICU) and cost about three times less than open heart surgery (30k€ vs 80+k€). It means a dramatic cost reduction for healthcare systems and a real improvement of the care of the elderly patient.This project holds the ambition to build a new gold standard in valvuloplasty worldwide, starting with mitral repair and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'HIV protease inhibitor resistance by enzyme-substrate coevolution' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Despite the success of antiretroviral drugs, therapy of HIV/AIDS still suffers from severe drawbacks because of undesired consequences of therapy. The major undesired consequence is resistance which renders individual drugs and complete drug classes ineffective. 70-80% of HIV-infected patients undergoing resistance testing carry drug resistant virus and 10% of new transmissions involve resistant or multi-resistant viruses. With the roll out of HIV therapy in developing countries, drug resistance will become a worldwide problem, while resistance development in non-subtype B strains of HIV (dominant in developing countries) is largely inferred from results obtained with subtype B viruses. Protease inhibitors (PI) have been a key factor in the success of HIV therapy, but as with all clinically used drugs resistance has been observed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Versatile printed solutions for a safe and high-performance battery system'.

assistant: **Concept**

In order to boost the transition to a climate neutral transport sector, VERSAPRINT will bring innovations to the battery system to tackle safety issues, enhance performances as well as decrease cost and environmental impact. The VERSAPRINT technical solutions will be achieved mainly by 2D/3D printing directly on battery components and will operate from the heart of the battery system (i) providing an efficient cell thermal regulation in order to reduce risk of Thermal Runaway (TR) and increase density and lifetime; (ii) significantly improving the system thermal and safety management thanks to in operando sensoring; (iii) adding thermal and safety-oriented functionalities on busbars; (iv) allowing easy and safe dismantling and re-manufacturing; (v) lowering the casing’s weight, without losing its capability to contain TR and while ensuring good recycling rate; (vi) providing an advanced thermal/fire response; and (vii) controlling the exhaust gases released during a TR by cooling and evacuating them safely.VERSAPRINT will also implement a Decision Tool in order to choose the most optimised configuration for a given end application and will provide a validation at TRL5 (i) at module level with two module prototypes (for automotive and aeronautics) as well as one virtual module prototype (for waterway transport); (ii) at system level through simulation for all these applications. Other applications such as bus, non-road mobile machinery and stationary storage will be explored as well, through simulation.VERSAPRINT aims to reach the cost and performances targeted in Batteries Europe 2030 KPIs, while increasing module density by 5% and significantly improving the battery system fire resistance and safety (no fire outside module during TR). Sustainability will be assessed at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multiphoton Ionization Nano-Therapy' to be submitted under Seventh Framework.

assistant: **Abstract**

The application of nanotechnology for addressing key problems in clinical diagnosis and therapy holds great promise in medicine and in cancer in particular. Recent works have shown significant progress in nanoparticle-mediated drug delivery and therapy. In these applications, however, the small dimensions of the nanoparticles have been used primarily for efficient delivery and specificity, while the effects mediated by the nanoparticles occur away from the particle itself, affecting the entire cell\tumour volume. We propose to study and develop, for the first time, a novel scheme for cancer therapy that treats cancer cells at nanoscale resolutions. Briefly, when noble-metal nanoparticles are illuminated with femtosecond laser pulses tuned to their plasmonic resonance, order-of-magnitude enhancements of the optical fields several nanometres away from their surfaces lead to local damage only to nearby molecules or cellular organelles. This process, which practically involves no toxic agents, is at the basis for this proposal; we will utilize techniques for targeting nanoparticles to cells, initiate and control cancer cell destruction using nanoparticles and femtosecond laser pulses, and develop technology for conducting image-guided minimally invasive cancer therapy in remote locations of the body. Preliminary results supporting the proposed scheme include nonlinear optical imaging and ablation of living cells, in vivo endoscopic imaging of cancerous tumour nodules, and computer simulations of light-nanoparticle interactions. Using state-of-the-art concepts in nanotechnology, biology, chemistry, and medicine, the proposed novel multidisciplinary research will attempt at offering a feasible and safe addition to existing forms of cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Personalized whole brain simulations: linking connectomics and dynamics in the human brain'.

assistant: **Concept**

Background. We have detailed maps of brain structure and function, yet are lacking understanding of how the highly connected units interact and give rise to mental processes. The Virtual Brain (TVB), a whole brain simulation framework, aims to bridge that gap. Yet it is still developing. We are proposing here breakthrough advances that reveal mechanisms of brain function and foster collaboration between research groups. Vision. Clinical applications that simulate individual patient brains and predict trajectories of recovery or decline or test therapies to select the best one for that person. Goal. Using biologically realistic brain models and multimodal functional and structural imaging data to elucidate control mechanisms of the human brain in aging. A database collects key data and allows identifying most generic models and mechanisms below the spatial and temporal resolution of non-invasive imaging techniques taking into account the complex interaction in the brain that without a model would be impossible to keep track of. Objectives. 1) Parameter optimization for large parameter space search and a library of dynamical regimes linking dynamical regimes and underlying mechanisms to biological (cognitive) age. 2) Identifying the role of intrinsic plasticity for network reconfigurations in the resting state and its age dependency. 3) Model based identification of task related plasticity mechanisms and their functional consequences for network reconfigurations in coordination learning in aging. 4) An interactive tool that provides access to the dynamical regimes library and makes pre-computed simulations easily accessible allowing researchers to benefit and learn from existing work. Impact. Understanding development, aging and brain disorders from the perspective of dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Nanoparticle-Assisted liquid biopsy based on Extracellular for Early Diagnosis of Glioblastoma' (NExGliO).

assistant: **Concept**

Glioblastoma (GB) is the deadliest primary malignant brain tumour, with a median survival of less than one year while current diagnostic methods suffer from significant limitations, leading to misdiagnosis and poor progression monitoring and are accompanied by invasive biopsy. Currently, there are no blood-based biomarkers available as support tool for GB management. A promising approach for such systems are liquid biopsies based on Extracellular Vesicles (EVs) that present a promising and minimally invasive approach. EVs act as versatile communication hubs, transporting a meticulously selected cargos that include various RNA molecules. The specific composition of EVs is influenced by their cell of origin, highlighting their potential as specific biomarkers for aggressive tumours such as GB. The NExGliO project aims for the development of multiplex biosensors for simultaneous detection on array of EVs-based ncRNAs signature specialized for GB diagnosis. This will be achieved via noble metal NPs which are frequently utilized as SERS substrates due to their strong plasmonic properties for ncRNAs detection. Supporting AI technologies will be developed to improve early-stage cancer diagnosis through ncRNA signature identifying algorithms. The NExGliO Staff Exchange brings together internationally recognised experts with complementary expertise from molecular biology, chemistry, nanotechnology, and AI to develop a robust platform for the early diagnosis and monitoring of GB, thus reducing reliance on invasive procedures and improving survival rates. The secondments and local training will synergize expertise from both academic and non-academic partners for a robust collaboration and to generate knowledge transfer between the consortium partners.The direct application of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Biodiversity Community Integrated Knowledge Library' (BiCIKL) targeting Horizon 2020.

assistant: **Abstract**

BiCIKL is a proposal that will initiate and build a new European starting community of key research infrastructures, establishing open science practices in the domain of biodiversity through provision of access to data, associated tools and services at (1) each separate stage of, and (2) along the entire research cycle. BiCIKL will provide new methods and workflows for an integrated access to harvesting, liberating, linking, accessing and re-using of sub-article-level data (specimens, material citations, samples, sequences, taxonomic names, taxonomic treatments, figures, tables) extracted from literature. BiCIKL will provide for the first time access and tools for seamless linking and usage tracking of data along the line: specimens → sequences → species → analytics → publications → biodiversity knowledge graph → re-use.


**Keywords:** biodiversity, genomics, literature, collections, taxon names, linked open data, biodiversity knowledge graph, open science, data interoperability, reproducibility, data extraction, publishing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Political Concepts in the World', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The POLITICO PhD programme will build on the success of the interdisciplinary training provided by the University of Aberdeen’s Centre for Citizenship, Civil Society and the Rule of Law (CISRUL), which specializes in the global application of political ideas.2 cohorts of 6 high-quality international ESRs will propose and develop their own research projects around the theme of how political concepts are deployed in the world. POLITICO ESRs will ask how, and with what consequences, policy institutes, social movements and media commentators invoke such ideas such as ‘nation’, ‘democracy’ and ‘civil society’. POLITICO will reach beyond the West to locate political ideas in South, Central and Eastern Europe, the Middle East and North Africa, South and East Asia, and Latin America and the Caribbean.Selection will be via an open, transparent, merit-based, impartial, equitable and internationally advertised process, which will take special care to allow free choice of research projects. With POLITICO’s inter-disciplinary supervision and inter-sectoral training, the ESRs will build careers not only in state-of-the-art research, but also in incisive policy design, social movement leadership, and influential media commentary. In these careers, the researchers will apply their acute awareness of how political concepts vary across contexts and are invoked in political action.To further develop the ESRs’ inter-disciplinary expertise, and to provide opportunities to present research and engage in debate, CISRUL will host a full series of seminars, workshops and conferences, all co-designed with ESRs and on topics that cross-cut POLITICO themes.POLITICO ESRs will be supported by 23 internationally-recognised partner organisations, committed to providing specific training to researchers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A Design Principle for Predicting Flexible Metal-Organic Frameworks', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Metal-organic frameworks, MOFs, are porous organic-inorganic hybrid materials that hold the potential for developing newtechnologies to tackle some of the pressing global challenges such as pollution, climate change and energy crisis. Their typical lowmass densities, high internal surface area, large pore volumes and facile chemistry makes them suitable for application in gas storage,filtration, extraction, catalysis and so on. Some MOFs are known to show a substantial degree of structural flexibility wherein theframework reversibly expands/contracts when subjected to external stimuli like pressure/heat/light or during absorption/desorption.This structural flexibility, if fully understood, can be used to enable the technological development of MOF-based recyclable filters,switchable catalysts, threshold sensors, stimulus-induced drug delivery systems with integrated key-lock functionality, compressiblegas tanks and so on. However, the origin of this flexibility has not yet been sufficiently understood to enable the rational design offlexible MOFs. This research project aims to provide a conceptual understanding on the origin of this flexibility at the atomic regimeby analysing all unique building units, topologies, and frameworks of all published MOFs to design a universally robust metric forpredicting flexibility and mechanical properties of MOFs with the overarching goal of providing a theoretical methodology for thecrystal engineering of flexible MOFs.


**Keywords:** Metal organic frameworks,  Mechanical properties,  Flexibility,  Machine learning,  Judgement of Energy Distribution, Analysis,  Prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovation Associate for Urban Innovation Lab project' (2014-2020) under Horizon 2020.

assistant: **Objectives**

We are delivering no-nonsense innovation and impact solutions for social, commercial and public partners. We are currently successfully growing a service line called ‘Urban Innovation Lab’ which supports European cities in developing and running social innovation labs. These are multi-stakeholder initiatives supported by a carefully designed and professionally facilitated creative process and pervasive technologies to help a district or a city create an innovative & sustainable public space and build a socially coherent & engaged community. We combine innovation process management, design thinking, innovation technologies and collaborative methods expertise to deliver state-of-the art support for such innovation labs. We are one of only a few companies in Europe with this very specialized expertise. As urban innovation labs / living labs / social innovation labs become an increasingly popular form of open innovation, being run by national and local governments, NGOs and businesses alike, we see the potential of very high growth in this domain. To leverage this opportunity, we are looking for an Innovation Associate to join our company. The Innovation Associate will research the current state-of-the-art of the urban social innovation scene, map potential partners and the locations with the best fit for this form of innovation support, develop the service itself (including the collaborative process and a toolbox of urban social innovation tools, techniques, templates and technological support), develop the social impact assessment methodology suitable for the lab context, participate in (potential) client meetings, assist in client proposal preparations, write and publish thought leadership pieces and represent the company in relevant events, networks, and conferences. Mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Tackling informal employment in Asia: building post-COV19 solutions to precariousness through case-study based evidence on Bhutan, Laos, Maldives, Myanmar, Philippines, Thailand and Vietnam'.

assistant: **Concept**

According to the last WESO report, there are over 1.4bn workers in vulnerable jobs worldwide, with numbers expected to rise in 2020 due to COVID-19. Several attempts have been made at both domestic and international levels to address these concerns. This includes efforts through the Sustainable Development Goals process, which includes a specific statistical indicator to measure informal employment (8.3.1), the formulation of SDG8 (decent work) and SDG9 (sustainable industrialization). Across countries and world regions, the degree to which SDGs have been used to address youth issues and inform national policies varies significantly. Indeed, in spite of the fact that the great majority of states have formally committed to addressing the SDGs, including those related to insecure employment, there is little evidence to indicate that developing regions currently have the capacity to systematically study the problems if informal employment and vulnerability in ways that facilitate the development and implementation of concrete viable solutions. This is due, in our view, to two major challenges. First, although a number of approaches that have been used inside the EU, there has been little, if any, attempt to adapt the existing framework elsewhere. Second, no systematic review of anti-precariousness policy has been attempted beyond the EU region. LABOUR is a research and training programme designed to address the above-mentioned shortfalls of research and development approaches with particular attention to a region where this is particularly worrying concern. Informal employment in Asia is estimated to account for 68.2% of the active population. By gathering a team of 14 participants that includes academic and non-academic partners working on labour insecurity, we aim not on