RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Combatting Bacterial Resistance in Europe', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The emergence of Antibiotic-resistant bacteria (ARB) is a global problem, having recently been elevated to the top three threats identified by the World Health Organisation (WHO), and subject of numerous national and international government activities, including the Trans-Atlantic Task Force on Antimicrobial Resistance established by the US and EU presidencies.  The estimated costs of ARB are around € 1.5 Billion per year in Europe, with an estimated 25,000 deaths (European Center for Disease prevention and Control/European Medicines Agency “time to react”). While the threat of antimicrobial resistance is growing, so are the challenges to bringing forward new therapeutic options for patients infected with resistant organisms. There is a need for a better understanding of how antimicrobial resistance is evolving globally, of what novel molecular mechanisms can be exploited as new forms of antimicrobial therapy and of how to more efficiently develop new treatments so they can be more rapidly brought to patients in need. The over-arching concept of New Drugs for Bad Bugs (ND4BB) is to create an innovative public-private collaborative partnership that will positively impact all aspects of ARB through the discovery and development of novel agents for the treatment, prevention and management of patients with bacterial infections. COMBACTE is one of the first projects to be launched under this programme with the aim of developing a broad European network of fully capable and Good Clinical Practice (GCP) compliant clinical investigation sites to execute clinical trials enabling the registration of novel agents to be used in the treatment of patients with bacterial infections.  The growth and application of the network will be supported with robust microbiologic surveillance da
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Sensory transduction in pain-sensitive neurones' under Fourth Framework.

assistant: **Concept**

The transduction of painful stimuli into nerve impulses in pain-sensiti neurones is poorly understood. The proposed project will use cultured neurones from the dorsal root ganglion, which are known to respond to a variety of painful stimuli, and will examine the electrophysiological response of the neurones to bradykinin, capsaicin and noxious thermal stimuli. Techniques to be used will include whole-cell and cell-attached patch clamp, calcium imaging using confocal microscopy, and receptor identification using immunohistochemistry and in situ hybridisation. Stimuli will be applied using a rapid solution change method. The principal projects will include (i) Biophysical characterisation of ion channels activated by bradykinin, capsaicin and thermal stimuli (ii) An investigation of signal pathways and internal transmitters underlying activation of ion channels by noxious stimuli (iii) An investigation of the mechanisms of response adaptation observed on repeated application of noxious stimuli (iv) An investigation of signal pathways activated by B1 receptors, using neurones from a B2 knockout transgenic mouse.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhancement of public transport efficiency through the use of mobile sensor networks' (MORYNE) targeting Sixth Framework.

assistant: **Abstract**

Project MORYNE aims to contribute to greater transport efficiency, increased transport safety and more environmental friendly transport by improving traffic management in an urban and sub-urban area.MORYNE will provide an effective co-operative system, by :- Using public transport vehicles (e.g buses) as elements of a network of mobile sensors, communicating with the infrastructure- Setting up co-operation between public traffic management and city traffic management.In the proposed Traffic Management System,- Public transport vehicles are equipped with sensors that collect data on the vehicle environment- Sensor data are processed locally and in real-time to generate information which are sent to a Public Traffic Management Centre through reliable and cost-efficient radio communications- The Public Traffic Management Centre generates decisions that are broadcasted to public transport vehicles and fixed points (like message panels at bus stations)- The collected information is also made available to a City Traffic Management Centre to provide an up-to-date picture of the traffic situation- The City Traffic Management Centre derives traffic management decisions that are broadcasted to distributed Traffic Control Devices (e.g. Variable Message Sign panels) and to vehicle drivers (via PDA, Internet).The project will focus on:- The development of an approach for new safety- and efficiency-oriented transport management and traffic management;- The development and validation of technologies for appropriate sensing, information processing, communication, interfaces;- The development of an in-laboratory demonstrator;- The validation of the proposed concepts through field testing with Berlin Buses Authority;- The analysis of potential impacts (social, economic, environmental) an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Anthropocene Frontiers: Colonial Climate Science in Siberia and Central Asia' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The AnthroFront project analyzes the relationship between climate science and colonial violence from the perspective of the Russian Empire’s Siberian and Central Asian frontiers in the earlier nineteenth century. Scholars have shown how climate science developed on the scale of Europe’s late overseas and land empires in the late nineteenth and twentieth centuries. Far less is known about the knowledge produced by earlier processes of conquest and the expropriation of Indigenous land. This project studies a cohort of Baltic-German scientists dispatched to Russian frontiers to understand how borderland encounters generated knowledge about climate change. The first comprehensive study of colonial climate sciences in the Russian Empire, this project develops a new framework for understanding interdisciplinary and intercultural exchanges of climate knowledge. The project gives historical context to contemporary policy debates and provides a pedagogical model for teaching climate history in public schools. Research integrates German and Estonian archives with digitized sources and focuses on three core themes: (1) the role of instructions in organizing colonial travel, (2) the dynamics of encounter between settler, Indigenous, and expeditionary groups, and (3) the circulation of knowledge from central Europe to Central Asia and back. The project will be carried out over twenty-four months in the Department of History of Science and Ideas at Uppsala University under the supervision of Dr. Linda Andersson Burnett, Senior Researcher in the history of colonial travel and indigeneity. The fellowship is also enriched by collaboration with Dr. Jennifer Keating at University College Dublin, a leading environmental historian of Imperial Russia. While advancing the MSCA Green Charter t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ice Chilling System for Enhanced Food Cooling' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The IceChilling project will demonstrate an enhanced cooling system as an add-on solution for the air chilling and spray chilling methods current used by most poultry meat processors. Food safety and quality are the main concerns of consumers who demand more fresh foods, longer shelf-life and safer foods. Western consumers eat 30-50 kg of chicken meat per person/year and they prefer fresh meat over frozen. As up to 75% of chickens are contaminated with Camphylobacter, this is a major concern and challenge for the meat industry and health authorities. Increased size of chickens, along with high speed slaughterhouse output requires more efficient cooling than is possible with the currently used technology alone. The ThorIce add-on solution provides increased chilling efficiency that is applicable in most current facilities, without the need to build larger chilling chambers or installing of longer conveyer belts. Therefore, offering great savings for the meat processor, as well as improved food quality and safety.The ThorIce group is a specialized manufacturer of high-quality ice-slurry generators with >300 units sold worldwide since 2006. ThorIce has now developed the new IceGun system (patent pending) composed of ice-slurry generator, circulation system and the IceGun unit that delivers dewatered soft ice onto a target, such as a chicken carcass on a conveyer belt. The primary customers are poultry slaughterhouses but also other meat and fish processing industries. The first ThorIce system has already been developed and demonstrated effectively at Matfugl chicken meat processor in Iceland and the next one is being developed for a Hungarian customer. The 1st phase feasibility assessment is intended to result in a comprehensive business plan for demonstration and marketin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Environmentally Friendly Coastal Protection in a Changing Climate' (EnviCOP), addressing dissemination and exploitation.

assistant: **Impact**

Based on previous collaboration, a group of 3 EU research organizations (from Italy, Portugal and Bulgaria) and 2 non-EU research organizations (from USA and Brazil), experienced in the area of research on environmentally friendly (soft) coastal protection methods, decided to bring together their expertise in an IRSES network - the project EnviCOP (Environmentally Friendly Coastal Protection in a Changing Climate).EnviCOP aims at strengthening research partnerships between the above organizations, primarily through short period staff exchanges of 14 Early stage and 7 Experienced researchers, as well as through various networking activities. Research activities of the project will focus on work-out/improve/coordinate advanced tools (numerical simulation and physical models) that are able to forecast short term and long term phenomena with respect to coastal protection in a changing climate.The project is expected to provide improved process understanding, new knowledge, methods, new and improved numerical and physical model tools, resulting in introducing new and improved environmentally friendly coastal protection structures.Project objectives will be pursued by exploring the available experience and scientific potential of all partners, using complementarities and creating synergies, based on existing previous collaboration.Project output should finally serve decision makers in strengthening emergency planning arrangements, improving co-ordination of coastal erosion and surface water flood risk; managing the investment of significant levels of public funding, and helping coastal communities adapt to climate change.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'H2moves.eu Scandinavia'.

assistant: **Innovation**

With this proposal the Scandinavian Hydrogen Highway Partnership (SHHP) applies for becoming the first EC funded European Lighthouse Project (LHP) for hydrogen fuel cell cars. Correspondingly, the LHP has been christened “H2moves Scandinavia” being synonymous to “H2moves.eu” as acronym for the cluster of European demonstration projects on hydrogen for transport. A state-of-the-art hydrogen refuelling station will be integrated in a conventional gasoline and diesel refuelling station in Oslo in early 2011, thus fulfilling all requirements specified in the call and offering the typical service profile of today’s conventional fuelling stations. The objective is to provide hydrogen in a normal retail setting with a fully integrated purchase interface and in an urban environment with probably the densest hydrogen fuelling station network anywhere in Europe. The user interface design will be intuitive, safe and easy to use, and the plan is to provide fully renewable hydrogen from electrolysis and hydropower. Ten Mercedes-Benz B-class F-CELL cars and an additional two Alfa Romeo MiTo fuel cell vehicles from Centro Ricerche FIAT will be provided for daily operation in Oslo and on specific tours in southern Norway and the whole SHHP region. In addition to these latest state-of-the-art fuel cell vehicles, five city cars from H2 Logic, mostly driven within the city of Oslo, will complement the vehicle fleet. The city cars will be based on a two-seater battery electric vehicle with a fuel cell range extender, being capable of up to 250 km driving range. Out of this fleet of customer cars, at least two cars (sedans and city cars) will be employed also on at least five European hydrogen vehicle demonstration tours. For the on-site refuelling of hydrogen during the vehicle demonstrati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Reaction to Emergency Alerts using voice and Clustering Technologies' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

REACT aims at reducing risks to citizens and the environment by enhancing the interactivity of citizens with Emergency Services and by providing added value to integrated information coming from disparate sources.REACT will:- capture more of the information available from callers and automatic systems;- complement the data with associated services able to semantically analyse and cluster environmental and crisis management information;- make data available to PSAP operators through a GIS-based interface;- allow the definition of operative scenarios to be used for an early identification of events and associated evolution patterns.REACT will support existing emergency systems by providing an interoperable multimedia Enhanced Emergency Call Service, that would operate on an everyday basis and deal with the small to mid size incidents, that unless properly handled and coordinated, could escalate in scale.The key contributions of REACT to the current emergency control services will be:- Integration of the emergency caller location featured by the E112 and eCall;- Call clustering and prioritisation through semantic, time, location - leading to clearer decision making and support (4D GIS);- Automatic identification of keywords from the PSAP operator speaking supporting the filling of a job description form for starting the emergency call workflow;- Interoperability across call centres and emergency services as REACT presents an XML GIS-based data store accessible using secure Web Services.REACT will normalize warnings from various sources, allowing their aggregation and analysis so that additional knowledge can be extracted and presented to the PSAP operator as an aid to situational awareness, pattern detection and dispatching of resources.The project includes demonstration i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Establishing international standards in the analysis of patient reported outcomes and health-related quality of life data in cancer clinical trials' under Horizon 2020.

assistant: **Concept**

Measuring and quantifying how a patient feels or functions during treatment is an important endpoint in cancer clinical trials. It is generally accepted that the collection of PRO data in cancer clinical trials allows the inclusion of the patient’s voice in the risk-benefit assessment of therapies. However, no standards exist on how to analyse, interpret or report health-related quality of life (HRQOL) and other patient-reported outcomes (PROs). This initiative wants to pursue efforts in addressing the urgent need for standardization, by setting clear and validated standards that are tailored to and endorsed by all relevant stakeholders. With a strong international and multi-stakeholder Consortium, the initiative aims at finding consensus on suitable methods to analyse valid PRO objectives in cancer randomized clinical trials (RCTs) and ways to communicate these PRO findings in a standardized way that is understandable to all. To achieve this aim, SISAQOL-IMI will identify valid PRO research objectives and match these with appropriate statistical methods for PRO analysis in cancer RCTs. Translation to the estimands framework will be provided. Furthermore, the possibility of extending these recommendations to single-arm trial designs will be explored. Recommendations on clinically meaningful change for PRO instruments, as well as design considerations and ways for assessing quality of collected PRO data will be developed, and tools and templates for presentation and visualization of PRO findings freely made available. Strong emphasis is put on continuous collaboration with patient advocacy representatives throughout the project. Increased interpretability, adoption and full use of PRO outcomes for all stakeholders is expected by providing consensus-based and validated re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Breaking and rebuilding the genome: mechanistic rules for the dangerous game of sex.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Sexual reproduction depends on the programmed induction of DNA double-strand breaks (DSBs) and their ensuing repair by homologous recombination. This complex process is essential for sexual reproduction because it ultimately allows the pairing and separation of homologous chromosomes during formation of haploid gametes. Although meiotic recombination has been investigated for decades, many of the underlying molecular processes remain unclear, largely due to the lack of biochemical studies. I have recently made important progress by, for the first time, successfully purifying proteins involved in two aspects of meiotic recombination: DSB formation and the final stage of formation of the crossovers that are a central raison-d’être of meiotic recombination. This has opened new avenues for future research that I intend to pursue in my own laboratory. Here, I propose a set of biochemical approaches, complemented by molecular genetics methods, to gain insights into four central problems: (i) How meiotic proteins collaborate to induce DSBs; (ii) How DSB proteins interact with components that form the axes of meiotic chromosomes; (iii) How proteins involved at later stages of recombination form crossovers; and (iv) How crossover proteins interact with components of synapsed chromosomes. For each problem, I will set up in vitro systems to probe the activities of the players involved, their interactions with DNA, and their assembly into macromolecular complexes. In addition, I propose to develop new methodology for identifying proteins that are associated with DNA that has undergone recombination-related DNA synthesis. My goal is to gain insights into the mechanisms that govern meiotic recombination. Importantly, these mechanisms are intimately linked not only to gamete formation