RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A microfluidic high throughput approach to helicase biophysics' (MUTAnTS).

assistant: **Innovation**

We propose a novel high-throughput method to study the chemo-mechanical coupling in molecular motors using helicases, enzymes that couple ATP hydrolysis to unwinding of the double helix, as a model system. The method combines a cell-free expression system, droplet microfluidics and fluorescent assays with next generation sequencing to test large (up to millions of elements) libraries of helicase mutants for both unwinding and ATPase activity. The aim is to identify all sequence positions that, if mutated, lead to uncoupling, i.e. abolish unwinding while preserving ATPase activity. Once these positions are identified, their distribution on the enzyme sequence and structure will be analysed to obtain insight into the coupling mechanism. Notably the methodology could be applied to systems where the classical, structure-based analysis of the chemo-mechanical coupling is not possible. We will demonstrate our method on the RecQ helicase from e. coli using existing information on this system as a means of validation. Any further insight will be a demonstration of the power of our approach. When fully developed, our method will serve as a discovery tool for the interdisciplinary community working on helicases that includes medical, biological and physical sciences. It may be applied to aspects of helicase biophysics beyond the chemo-mechanical coupling, to other enzyme families and to screen for helicase inhibitors with higher throughput and lower cost when compared to robotic mictotitre-plate techniques. The proposed work will be carried out at the Griffiths Lab (ESPCI Paris) with a secondment at the Crick Institute (London). This project integrates the training in biophysics of the Experienced Researcher with the expertise of the Host Institution on high-throughput methods an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Fellowships in Advanced Cultural and Social Studies at the Max-Weber-Kolleg'.

assistant: **Concept**

The MWK-Fellows programme financed by COFUND aims to allow excellent incoming researchers from countries other than Germany (in accordance with the EU-mobility-rule) to conduct their own, freely chosen, independent research projects in a highly competitive and intellectually vibrant research environment provided by the Max Weber Center for Advanced Cultural and Social Studies (Max-Weber-Kolleg). The Max-Weber-Kolleg is a high-ranking research centre which forms an avant-garde institution of the University of Erfurt. It is distinguished by a unique organisational structure – combining the features of an Institute for Advanced Study and a Graduate School – and a ‘Weberian’ research programme. The ‘Weberian’ research programme combines historical, comparative and interdisciplinary perspectives with an interest in normative issues in the social sciences. It has a focus on societal challenges of contemporary societies, especially (religious) plurality, cultural diversity and social order, processes of acceleration and growth. The core disciplines are sociology, economics, religious studies, law, philosophy and history, but MWK-Fellows programm is open for related areas as well.The Max-Weber-Kolleg is based on the principles of interdisciplinarity and internationality with a long-standing and progressively fine-tuned fellowship programme. By means of the COFUND-action Max-Weber-Kolleg will not only increase the number of international fellows but include a new intersectoral dimension into its fellowship programme.At the Max-Weber-Kolleg, MWK-Fellows will enjoy the best possible support and an opportunity of being connected with larger research projects. Nevertheless the applicants’ freedom of choice of the research project is fully guaranteed.The MWK-Fellows programme will im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Translational SYStemics: Personalised Medicine at the Interface of Translational Research and Systems Medicine' (TranSYS) targeting Horizon 2020.

assistant: **Abstract**

TranSYS will recruit 15 ESRs to highly skilled jobs in the new area of Systems Health developing tools and approaches to exploit large and complex datasets, to advance Precision (Personalised) Medicine in several disease areas. The training programme and experience of different international research environments cuts across traditional data and life sciences silos. The emphasis on translational research will support new collaborations between academics and the pharma and health analytics sectors. Our ESR projects will advance the state of the art on biomarker discovery, improve understanding of disease-specific molecular mechanism and target identification for optimal diagnostics, disease risk and treatment management, refine data generation and their management (including warehousing, disease specific and standardised approaches for data processing, visualisation and model development) leading to improved clinical study design, clinical sampling and more targeted therapeutics. This ETN will internationalise participants, and leverage EC and industry sponsorship, to structure and expand the unique training programme and advance emerging research areas, combining wet-lab, clinical and Big Data resources with computational and modelling know-how. To achieve a paradigm shift in research training this ETN brings together international leaders in Preclinical Science & Molecular Medicine, Systems Analytics, and Targeted Therapeutics, from academia and industry. These experts are ideally positioned to develop the proposed training programme and deliver a highly-trained workforce of next generation scientists, with the right mind-set, knowledge and skills, at the interface of Translational and Systems Medicine. The TranSYS training programme is designed to address a critical s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Framework to IMPROVE the Integration of Patient Generated Health Data to Facilitate Value Based Healthcare' (IMPROVE).

assistant: **Concept**

IMPROVE will use Patient Generated Health Data (PGHD) gathered via m-health and e-health technologies to gain improved insights into the real-life behavior of, and challenges faced by, patients of all ages with complex, chronic diseases and comorbidities. Already today, a wealth of patient and citizen information is available, but fragmented, and therefore not coming to its full utility and value. These personal data will complement and improve existing approaches for Patient-Centered Outcome Measures beyond those currently available in state-of-the-art platforms. The IMPROVE platform that the consortium will build will enable the smart use of patient input and patient generated evidence to 1) advance the role of patient preference and patient experience in the context of treatment selection, 2) improve medical device design based on patient preferences and experiences, and 3) facilitate faster market entry of patient-centric and cost-effective advanced integrated care solutions. Improved clinical adoption of Value Based Health Care, and enhanced return on research and innovation investments will be demonstrated in different care settings across the EU, for 10 use cases in at least 5 different disease areas (e.g., ophthalmology, oncology, cardiovascular disease, chronic inflammation, and neurology). The use cases will be conducted using a large variety of implementation strategies, building on a design thinking approach, to optimally test the innovative framework of data gathering and translation into controlled change and action. In addition, a significant contribution from implementation science is planned to reach out to all stakeholders that are relevant for this initiative and maximise the impact to IMPROVE healthcare provision.


**Keywords:** Patient Generated He
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evolutionary origin of multicellularity and the oxygenation of Earth' (EVOXY), addressing dissemination and exploitation.

assistant: **Impact**

The origin of multicellularity is considered a major transition in the evolution of life. It has independently evolved over 20 times in different pro- and eukaryote lineages. Underlying genetic mechanisms are still far from being understood. Moreover, it seems that the transition to multicellularity in cyanobacteria might have be correlated to the “Great Oxidation Event” (GOE), over 2.4 billion years ago.  Here, I propose an ambitious multidisciplinary project, (i)  to study the genetic mechanism that enabled the transition to multicellularity and (ii) to test the hypothesis that the accumulation of atmospheric oxygen is a consequence of the origin of multicellularity in cyanobacteria. Multicellularity might have been a key innovation during cyanobacterial history triggering adaptive radiation and abundance, consequently changing the biogeochemical cycles of Earth. To test this hypothesis I propose to resolve the timing and nature of  cyanobacterial evolution, combining phylogenomic studies with palaeontological data. 30 cyanobacterial species have been chosen for next generation sequencing adding to the full genetic and morphological diversity of this phylum. The resultant data will be used for phylogenomic studies. Distinct gene sets associated with different multicellular lineages will be identified and their history reconstructed using Bayesian and maximum likelihood methods. Furthermore, cyanobacterial fossils from various ages will be analyzed applying different “state-of-the-art” analytical tools, such as Synchrotron X-ray tomography, and will be incorporated in an elaborate phylogenetic dating analyses using a Bayesian approach with different clock models. Results will be critically evaluated and compared to palaeoclimatic data, to reconstruct the origin and div
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Life history of microalgal species causing harmful blooms' (LIFEHAB).

assistant: **Concept**

It is recognized that life strategies, heteromorphic life cycles and behaviour strategies (i.e. ent-excystement rates, vertical migration) play a key role in Harmful algae blooms (HAB) occurrence and dynamics; The interaction between different life history-stages and their relationship with the physical, chemical and biological environment are a very important element for the success of harmful species. In spite of the key role that life history strategies play in bloom dynamics, information on the life history of most European HAB species is fragmentary. LIFEHAB will be a forum of debate between European specialists in life history strategies of micro algal species causing HABs. The main goals are: to find out gaps in current knowledge, to determine the most appropriate methodologies, to identify future HAB research strategies in Europe and to promote the development of co-operative initiatives in that topic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Preventing, avoiding and mitigating environmental impacts of fishing gears and associated marine litter' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

NETTAG+ aims to provide a portfolio of three suitable innovative smart and sustainable solutions to address the negative impacts of fishing gears on marine life and habitats, in line with the second issue of the call “Environmental impacts of fishing gears”. NETTAG+ will be based on synergistic activities between the fisheries industry, scientists and NGOs to develop three solutions to PREVENT, AVOID and MITIGATE the harmful impacts of fishing gears. We will PREVENT marine litter derived from fisheries activities, AVOID loss of fishing gears, and MITIGATE harmful impact by removing existing ALDFG. These three solutions will jointly contribute to reduce ALDFG and marine pollution, namely by: reducing the introduction of hazardous chemicals and microplastics originated from ALDFG; reducing ghost fishing, bycatch and entanglements of sensitive or endangered species on ALDFG; and improving mapping, tracking and recovery technologies to retrieve ALDFG. NETTAG+ aims to upgrade and upscale the integrative preventive approach started in the previous NetTag project, and replicate it in Mediterranean regions. The three solutions will be developed to maturity (TRL 7-8) by the end of the project, and will be tested, validated and demonstrated in real conditions in Atlantic and Mediterranean countries, namely Portugal (PT), United Kingdom (UK), Spain (SP), Italy (IT), Croatia (HR) and Malta (MT). NETTAG+ ambition is to change the paradigm of the fisheries industry, aspiring to transform the societal perspectives about the role of fishers as Guardians and Cleaners of the Ocean. NETTAG+ will empower the sector to take active actions to address marine pollution, promoting their role as key-actors to tackle marine pollution, and will will provide the fisheries industry with three smart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Innovative Intelligent Rail' under Horizon 2020.

assistant: **Concept**

IN2RAIL is to set the foundations for a resilient, consistent, cost-efficient, high capacity European network by delivering important building blocks that unlock the innovation potential that exists in SHIFT2RAIL: innovative technologies will be explored and resulting concepts embedded in a systems framework where infrastructure, information management, maintenance techniques, energy, and engineering are integrated, optimised, shared and exploited.  IN2RAIL will make advances towards SHIFT2RAIL objectives: enhancing the existing capacity fulfilling user demand; increasing the reliability delivering better and consistent quality of service; reducing the LCC increasing competitiveness of the EU rail system.To achieve the above, a holistic approach covering Smart Infrastructures, Intelligent Mobility Management (I2M)and Rail Power Supply and Energy Management will be applied.Smart Infrastructure addresses the fundamental design of critical assets - switches and crossings and tracks. It will research components capable of meeting future railway demands and will utilise modern technologies in the process. Risk and condition-based LEAN approaches to optimise RAMS and LCC in asset maintenance activities will be created to tackle the root causes of degradation.I2M researches automated, interoperable and inter-connected advanced traffic management systems; scalable and upgradable systems, utilising standardised products and interfaces, enabling easy migration from legacy systems; the wealth of data and information on assets and traffic status; information management systems adding the capability of nowcasting and forecasting of critical asset statuses.Rail Power Supply and Energy Management create solutions to improve the energy performance of the railway system. Research on new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Grassroots economics: Meaning, project and practice in the pursuit of livelihood.' (GRECO).

assistant: **Innovation**

In Southern Europe promises of wellbeing and social mobility have become increasingly elusive since 2008. Economists and policy makers have provided analyses and advised on political action to end the economic crisis, but this has often resulted in greater precarity producing social protest as well as nationalistic and xenophobic reactions. Expert’s accounts are based on mainstream economic models designed to provide monetary stability and growth through enhanced competition in open markets. These models are ‘technical’ and top-down models that largely ignore political, social and cultural dynamics on the ground. Yet social agents are embedded in multiple regimes of value and institutional frames that guide their economic behavior.Four Southern European countries –Portugal, Italy, Greece and Spain— have been strategically selected as research sites due to their relevance in the current European crisis. The project investigates grassroots economics by addressing the social, cultural and political environments in which common people make everyday economic decisions. Through an interdisciplinary approach that uses ethnographic fieldwork and comparative analysis, it highlights the interaction between individuals, households and institutions from a threefold perspective 1) as creating meanings in which the value(s) of action are assessed, 2) as defining the material and ideological conditions of possibility for designing projects, and 3) as providing resources and creating various distribution patterns. It explores the relationship between authoritative models of the economy and the real economic projects and practices of those whose main objective is the pursuit of livelihood.The comparison of grassroots economics with mainstream expert economics will support a theoreticall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'The linguistic and cognitive representation of motion events'.

assistant: **Concept**

The study addresses the issue of the relation between language and cognition and seeks to assess whether language-specific patterns influence linguistic and cognitive activities across speakers of French and Polish. These languages differ in the way they encode two basic parameters associated with motion, Path and Manner: while Polish expresses Path in the prefix and Manner, obligatory, in the main verb [in-run, out-run], French tends to express Path in the main verb and Manner, optionally, in a gerund [enter (running), exit (running)].The aim of the study is to scrutinize by psycholinguistic means the discursive and cognitive implications of these typological patterns. Grounded in an interdisciplinary approach, the study combines two psycholinguistic methods based on videotaped acted events of motion: a linguistic task of verbal description and a cognitive task of similarity judgments. The study seeks to assess whether and how language-specific patterns determine the particular aspects of motion events, such as Manner and/or Path, on which speakers focus in performing these tasks.The projected contribution of the project is(1) to document typological patterns and discursive construction of the information related to motion events in French and Polish,(2) to evaluate the effect of language typology on linguistic and non-linguistic cognition, and(3) to gain insight into factors that determine and constrain linguistic and non-linguistic processing.The results of this study will enhance our understanding of cognitive processes underlying linguistic structure and will have implications for both linguistic and psychology.