RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Next Generation of Heat Pumps working with Natural fluids' (NXTHPG), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of the project is the development of several reliable, safe, high efficiency and high capacity heat pumps working with the two most promising natural refrigerants: Hydrocarbons andCO2, together with a set of improved components and auxiliary devices adequate for the efficient and safe use of the two refrigerants.The project aims to reach a higher efficiency (10-20% SPF improvement) and lower Carbon footprint (20% lower TEWI) than the current state of the art HFCs/HFOs or Sorption heat pumps. The costs shall be very similar or slightly higher than the latter systems (10%). The project will also focus on the development of an efficient capacity modulationin order to enhance the integration capability with other renewable sources in the energy systems of Buildings and Industry. In this sense, if the project is successful, it will clearly bring a definitive step forward to overcome the barriers holding back thespread of natural refrigerants by proving that a new generation of heat pumps based on HCs and CO2 is perfectly feasible and commercially competitive.The first objective of the project is the identification of the cases in which the use of Natural refrigerants can lead to cost effective and high efficient solutions with a fast commercial exploitation. The following cases have already been identified for their potentialinterest:-Hydrocarbons (HCs): air or water to water heat pumps supplying hot water at (40-50ºC) for heating applications as well as to produce sanitary hot water at 60ºC.-CO2: heat pump of high capacity to produce sanitary hot water at 60ºC directly from city water (10-15ºC). Designs with higher temperatures in the range 70-90ºC should be also explored.The project involves 6 key industrial partners (component manufacturers and heat pum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'BRIDGE: Bridging resources and agencies in large-scale emergency management' (BRIDGE).

assistant: **Concept**

The goal of BRIDGE is to increase safety of citizens by developing technical and organisational solutions that significantly improve crisis and emergency management. The key to this is to ensure interoperability, harmonization and cooperation among stakeholders on the technical and organisational level.Therefor BRIDGE delivers:-Resilient ad-hoc network infrastructures, focussing on the requirements evolving from emergency scenarios-Generic, extensible middleware to support integration of data sources, networks, and systems-Context management system to foster interoperability of data, providing meaningful, reliable informationTechnical interoperability is crucial for improving multi-agency collaboration and continuous training, but its full potential can only unfold, if technology can be integrated and sustained into agency workflows and communication processes. On the level of organisational harmonisation, BRIDGE will provide:-Methods and tools that support run-time intra- and inter-agency collaboration-Model-based automated support system combined with scenario-based training-Agent-based dynamic workflow composition and communication support systemMaking available an increasing amount of data for crisis response systems has to be accompanied with developing intelligent human-computer interaction models to make these data usable. BRIDGE will contribute to this by developing:-Adaptive, multi-modal user interfaces-Novel stationary and mobile interaction techniques-Approaches on how to raise awareness through visualization of ad-hoc networksBRIDGE is committed to an iterative user-centred approach incorporating and validating user and domain requirements.The consortium consists of a well-balanced mix of cross-disciplinary academics, technology developers, domain experts an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Low oxygen, key ingredient of the plant stem cell niche?' in the context of a Horizon Europe call.

assistant: **Objectives**

Oxygen (O2) is essential for efficient energy conversion by multicellular organisms, including plants. Therefore, environmental conditions where O2 is limited (hypoxia) such as during flooding stress, pose a severe threat to plant survival and can lead to death when prolonged. I recently discovered that plant stem cells of the shoot apical meristem (SAM) are embedded in a local hypoxic niche and that this condition is even important for meristem activity. This suggests that local hypoxia may play a positive role in regulating meristems, despite being harmful to other plant tissue. Safeguarding  the stem cell pool of the SAM is especially important for plant fitness, since it not only produces all above ground tissue, but also specifies the germline. In this project, I will therefore challenge the paradigm of hypoxia as a solely stressful conditions and propose that local hypoxia might create a protective environment for stem cells, whereas oxygenation outside the meristem might allow growth of differentiating organs. I will address this hypothesis via three interlinked strategies. (1) Complete the development of prototype O2 biosensors, which will unlock the ability to visualize and understand the role of O2 gradients in plant tissue. (2) Employ genetic manipulation of the O2 sensing machinery to test if and how O2 gradients provide a positional cue that spatially organizes the SAM and its derived organs. (3) Investigate the role of meristem hypoxia in formation of DNA-damaging radicals from O2 metabolism and study the evolution of the hypoxic niche and its perception.Protection of meristems and differentiating organs is essential for plants to survive flooding events which are increasing in frequency due to global warming. The novel insights on how O2 levels regulate d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Co-constructing interactive short and mid-tier food chains to value agrobiodiversity in healthy plant-based food' in the context of a Horizon 2020 call.

assistant: **Objectives**

The overall objective of this multi-actor, participatory project is to facilitate the use and increase the value of Neglected and Underutilised Crops (NUCs) in food chains to foster healthier diets and more sustainable food systems. To achieve this, DIVINFOOD will focus on interactive short and mid-tier value chains that can meet the growing consumer demand for: 1) healthy plant-based food; 2) products with a local/regional identity, and 3) diverse services and benefits received from agriculture and food. DIVINFOOD will study minor cereals and legumes in 3 geographical regions that face various climatic hazards and diverse socio-economic challenges to developing agrobiodiversity-rich value chains. DIVINFOOD will: - Co-develop, with consumers, new interactive marketing modes and channels valuing biodiversity use and its services/benefits, with the support of participatory guarantee systems and digital tools- Co-produce new and diversified plant-based healthy and appetising products and recipes from NUCs meeting consumers’ needs, from minimal or mild food processing and formulations better expressing NUCs’ potential- Benchmark diverse agroecological farming systems and techniques that improve NUCs’ performance, inter-specific biodiversity and the provision of citizen-focused agro-socio-ecosystem services- Breed more performant cultivars of cereals and legumes with local adaptation, intra-specific biodiversity, biotic and abiotic stress tolerance, and potentiating nutritious and appetising food- Demonstrate new business models that diversify income and activities for farmers and small-scale processors who are using agrobiodiversity- Co-design pilot multi-actor territorial networks/social cooperatives in charge of managing, propagating and promoting NUCs. Design policy reco
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Improvement of effort, cost estimation and cost control' (COCOSPIE), addressing dissemination and exploitation.

assistant: **Impact**

The growing competition in the software business constantly increases the pressure on companies' potential profit margins, intensified even by low price offers from Eastern European countries. Therefore a reliable effort and cost estimation becomes a major concern for many software vendors.As a significant amount of Philotech's offers were rejected, because effort and cost were estimated to high and up to 25% of the projects ended without a profit or even with a loss, Philotech identified the effort and cost estimation and control as the part of the development process to be improved. To gain the capability to estimate the effort and cost of all projects within a sufficiently narrow confidence interval is the objective of this experiment.THE EXPERIMENTAfter evaluating the available cost estimation methods and tools, data of suitable former projects accomplished by Philotech will be inserted into a project database and used to calibrate the parameters of the selected cost estimation model and tool.Finally, the Baseline Project, which is typical for Philotech's area of software development, serves to validate the calibrated model(s) and tool(s). The estimated effort and cost figures, provided by the calibrated model/tool will be compared to the real effort and cost of the Baseline Project.EXPECTED IMPACT AND EXPERIENCEThe experience gained during the PIE should give Philotech the capability to estimate the effort of all projects within a margin of 10 to 15% and to perform all projects within budget. Philotech plans to form a team of experts to support and train the staff of the company in estimating effort and cost for software projects. Additionally, this training will also provide them with the knowledge to early identify cost drivers in a project and to take timely mea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Stem Cell-Derived Exosomes for the treatment of Traumatic and Degenerative Eye Disease' (EXO-EYE).

assistant: **Concept**

The death and dysfunction of retinal ganglion cells (RGC) is a major cause of blindness in traumatic and degenerative ocular disease. For example, 60M people are affected by glaucoma with 4.5M becoming blind in both eyes, whilst optic neuritis affects 5/100,000 people and represents a significant problem for sufferers. RGC are the sole projection neurons and their axons make up the optic nerve, making them exquisitely sensitive to injury. As CNS neurons are irreplaceable, neuroprotective strategies are paramount to therapies aimed at preserving vision but as of yet, no such therapy exists. Current research has demonstrated significant neuroprotection by mesenchymal stem cells (MSC) including those from the bone marrow (BMSC), acting not as replacements for RGC but rather, as paracrine-mediated support cells. Clinical trials are already ongoing to test their efficacy in patients. Despite this, the exact mechanism behind their neuroprotective potential is not well understood. Recent studies have shown that exosomes, extracellular vesicles containing proteins, mRNA and miRNA may mediate much of the paracrine support offered by MSC and thus act as an easily purifiable cell-free alternative therapy for RGC neuroprotection. This proposal aims to assess the therapeutic efficacy of BMSC-derived exosomes, their characterisation and that of their RNA cargo. We will test these exosomes in animal models of traumatic (optic nerve crush) and degenerative (glaucoma) eye disease. Specifically, this proposal employs a novel strategy to promote RGC survival (relevant to ONC and glaucoma) and axon regeneration (relevant to optic nerve crush) through the use of exosomal delivery of mRNA/miRNA into injured RGC utilizing in vitro and in vivo injury models, RNAseq and CRISPR technology.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Eurexpress, a european consortium for large-scale gene expression analysis by rna in situ hybridization' to be submitted under Fifth Framework.

assistant: **Abstract**

High resolution analysis of gene expression can be performed by RNA in situ hybridization, which allows definition of gene expression with great accuracy, this revealing temporal gene activity in individual cells or groups of cells. To apply the power of this high-resolution procedure to the vast resource of cDNAs contained in the evergrowing public sequence databases, seven European groups decided to undertake a concert effort in: a) developing a plan for international coordination on gene expression studies; and b) carrying out a high-throughput expression study of a large number of genes of high biological interest in developing mouse and human embryos as well as in adult mouse brain.The main objectives of this proposal are:1)Select and retrieve a collection of genes of biological value based on extensive bioinformatic analysis of public sequence database. This selection will be based on an extensive bioinformatic analysis of public sequence databases, such as dbEST and UniGene.2)Perform a high-throughput expression study of the genes identified in objective 1, in developing mouse and human embryos and in adult mouse brain. The high-throughput in situ hybridization studies will be conducted by using an automated in situ hybridization (ISH) procedure, under development by the applicants. Using these procedures, 2,000-6,000 murine and 200-400 human cDNAs will be analyzed in the course of this project.3)Construct two project-specific database (Mapped Image Database and Archive Image Database) for the submission, storage, management and release to the scientific community of the expression data generated in this project.The high-throughput RNA in situ hybridization analysis described in this proposal will:-be of crucial importance to better understand the physiological r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development and Characterisation of New Immunogenic GEMMs of Lung Cancer' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

Many studies have recently archived a remarkable clinical efficacy of immunotherapeutic treatments in several cancers including non-small cell lung cancer (NSCLC). However, these approaches are not always successful and it is currently impossible to predict a therapeutic response or serious adverse event. These fundamental issues need to be addressed and, to recapitulate the complexity of interactions between immune cells and cancer, this has to be done in vivo. However, genetically engineered mouse models (GEMMs) of NSCLC do not mirror the genomic instability and the high mutations rate of their human counterparts. Consequently, these tumours rarely present neo-antigens that can induce an immune response, and are considered poorly immunogenic. To our knowledge, a genetically defined model of an immunogenic spontaneous tumour does not exist. Here, we propose to develop such an immunogenic GEMM (iGEMM).The leading mouse model of lung cancer is the GEMM Kraslsl-G12D/wtTrp53fl/fl (KP). We propose two strategies to induce either genomic instability or mutation rate in the KP model. 1) We will overexpress Mad2, a component of the mitotic spindle assembly checkpoint, to induce aneuploidy in KP tumours; 2) We will overexpress the cytidine deaminase Apobec3 to increase the mutation rate of KP tumours.The resulting immunogenic GEMMs (iGEMMs) will be characterised and used to assess new therapies that trigger an immune response and to address mechanisms which drive immunotolerance. iGEMMs will facilitate the investigation of currently available immunotherapies which will help predict clinical response to these therapies and investigation on alternative strategies to treat resistant lung tumours. All together, these investigations will provide novel information regarding the best
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Knowledge brokerage to promote sustainable food consumption and production: linking scientists, policymakers and civil society organisations' to be submitted under Seventh Framework.

assistant: **Abstract**

The policy issue central to this project is food as many of today’s sustainability problems (e.g. water shortage, GHG emissions, pollution of soil and water, decrease of biodiversity, urban waste) are related to the prevailing pattern of food production and consumption (including processing and distribution). Hence, developing more sustainable food production and consumption patterns will have a significant impact on sustainable development in general. This project aims to develop and experiment with new integrative modalities of linking research to policy-making in the field of sustainable food consumption and production, thereby contributing to the establishment of new policy-relevant communities of researchers, policy makers & CSOs and enhancing the use of research insights in policies to promote sustainable food systems. Three different Communities of Practice will be developed, focusing on different dimensions of a newly emerging integrated territorial food geography: a) short food supply chains, b) sustainable public food procurement, and c) urban food strategies. Like the FOODLINKS consortium, each CoP will consist of researchers, policymakers and CSO representatives. In this project we will monitor and evaluate the knowledge brokerage activities in the CoPs, in order to propose new ways of linking research and policymaking in the food domain as well as in other public domains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Macrobenthic communities associated with deep wood falls lying in submarine canyons' under Seventh Framework.

assistant: **Concept**

Life in the deep-sea ecosystems is generally dependent on the constant rain and fall of particles and matter from the photic zone and the continental shelf. Submarine canyons may trap and concentrate large organic falls (e.g. terrestrial debris and sunken wood) from wide areas. Its accumulation on canyon floor creates “islands” that contribute to deep-sea species diversity and dispersal. Therefore, it is widely accepted that submarine canyons may play a significant role in enhancing shelf-basin exchanges and may be biodiversity hotspots.DeepFall focuses on studying the spatial distribution, temporal succession and population connectivity among species from macrobenthic communities associated to wood falls from various submarine canyons. These communities and the objectives targeted in this proposal are poorly known worldwide, and have never been studied in submarine canyons. Within the DeepFall, diverse studies on the ecology, physiology and population dynamics of these communities will be carried out in seven submarine canyons, three Mediterranean, one Atlantic, and three Pacific.The main objectives are: 1) to investigate canyons’ macrobenthic community succession in sunken wood; 2) to study the biology and physiology of Xylophaga spp. (the primary wood degrader in deep-sea ecosystems); 3) to study population genetics and phylogeography of Xylophaga spp. using nuclear and mitochondrial markers.4) to study population connectivity among canyons. In conclusion DeepFall will predict the potential dispersal and connectivity of species among high priority conservation areas such as submarine canyons. DeepFall will also investigate the matter and energy exchanges between coastal and deep-sea regions, and the potential impacts of episodic climate/oceanographic events on deep-s