RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Understanding the roles of mammalian sialidases in glycolipid catabolism'.

assistant: **Objectives**

Sialidases are widely distributed in nature, from microorganisms to mammals. Mammalian sialidases differ in their tissue distribution, subcellular localization, substrate specificity and pH optimum. To date, several mammalian sialidases have been cloned; a lysosomal form (Neu1), a cytosolic form (Neu2), a plasma membrane-associated form (Neu3) and a lysosomal/mitochondrial form (Neu4). Defining the functional impact of sialidases on complex physiological and cellular processes should uncover the biological significance of sialidase-susceptible sialic acids on glycoproteins and glycolipids. Our goal has been to clarify biological functions of mammalian sialidases. Recently we investigated the role of lysosomal/mitochondrial sialidase Neu4 in glycolipid degradation using mouse model with the combined deficiency of β-hexosaminidase A (HexA) and sialidase Neu4. Our mouse model progressed toward the neuropathological abnormalities of human Tay-Sachs patients.  The appearance of epileptic seizures and increased glycolipid storage demonstrated the predicted increased severity of disease indicative of the importance of Neu4 in glycolipid degradation but it is clear from the much milder than expected phenotype that other sialidases such as Neu1 and Neu3 also contribute to catabolism reactions. We now propose to investigate the intralysosomal mechanism by which glycolipids are degraded by sialidase Neu1 using  mouse models. Therefore, the main objectives of this proposal are: (1) to generate first Neu1-/- knockout mouse models (2) to generate Neu1-/-HexA-/- (3) to generate Neu1-/-Neu4-/-HexA-/- triple knockout mouse models. If successful, our studies will significantly increase the state of knowledge of sialidase contribution in glycolipid degradation and can suggest new therapeu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Provision of Scientific, Technical and Administrative Management of COST' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

This EC-ESF COST II Grant Agreement is meant to provide support to COST over the duration of the 7th Framework Programme, i.e. at least 91 months in total, as defined in the Specific Programme “Cooperation”. It is implemented through an initial period from 2 June 2007 to 1 June 2008 followed by yearly amendments to cover the whole duration of FP7.COST is a unique means for European researchers to jointly develop their own ideas and new initiatives across all scientific disciplines through trans-European networking of nationally funded research activities. Based on a European intergovernmental framework for cooperation in science and technology, COST has contributed since its creation 40 years ago to closing the gap between science, policy makers and society throughout Europe and beyond.COST's mission is to enable, through a “bottom-up” approach open to all science and technology domains including interdisciplinary, new and emergent fields, break-through scientific developments leading to new concepts and products and thereby contribute to strengthen Europe’s research and innovation capacities.COST, as an integral part of the ERA, is putting particular efforts in rein-forcing its activities and impact in European countries where excellent researchers need to gain visibility at European and global level by con-necting them throughout Europe, building trust, and contributing to strengthen their capacities.COST is governed by the COST Committee of Senior Officials (CSO), which is composed of representatives of 35 COST Member Countries (plus one cooperating state) and elects its President for a renewable mandate of three years.COST is financed by the EU through a budget from the Framework Pro-grammes for research, technological development and demonstration activities and ha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ruthenium-based photoactivated chemotherapy against eye cancer' (Ru4EYE).

assistant: **Concept**

The Ru4EYE PoC proposal will develop the first pre-clinical evaluation of Ru-based PACT compounds in uveal melanoma (UM) model. UM is a rare malignancy of the eye. Although treatment against UM do exist, they do no always preserve vision or the eye, and often lead to patient death via metastasis to the liver. A better treatment that would save vision, the eye, and the patient, is looked after. UM appears as an appealing disease for photoactivated chemotherapy (PACT), a new form of phototherapy developed within my ERC Starting Grant RuProLight. PACT agents are photosensitive compounds that can kill cancer cells selectively under the action of light. In PACT dioxygen does not need to be present at the site of light irradiation because the mechanism of photochemical activation is an oxygen-independent bond breakage reaction between a bioactive, cytotoxic agent, and a light-removable protecting group. Innovative therapeutic solutions such as PACT are typically difficult to bring to the market because of the risky nature of drug development and the funding required for clinical trials. The vision in this grant proposal is that positive results on a rare form of cancer such as uveal melanoma could not only offer a relatively short-term solution to uveal melanoma patients, but also accelerate translation of Ru-based PACT to the clinics by driving developments for other diseases as well. The biological testing of Ru-based PACT compounds will be performed in a complete series of translational cancer models: from in vitro (2D monolayers of normoxic and hypoxic cancer cells, 3D tumor spheroids) to in vivo (xenografts in zebrafish embryo for studying metastasis formation and treatment, and mouse model for in vivo toxicity and efficacy). The aim is to develop a pre-clinical proof-of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Access to Risk Finance and SMEs NCP cooperation network' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The main objective of this action is to empower the network of National Contact Points (NCP) for Small medium-sized enterprises - SMEs and Access to risk finance (SMEs, ARF) under Horizon2020, by promoting a systemic service and knowledge provider for SMEs, industry and ARF community. Such knowledge and service provider will include collaboration and networking with relevant networks in thematic areas across the three Pillars of Horizon 2020, as well as networks focusing on SMEs such as the Enterprise Europe Network - EEN.Special attention will be dedicated to strengthening the knowledge of less experienced NCPs from Member States (MS) and Associated Countries (AC) in order to deliver professional cross borders know-how including the EU, National and regional level The Network will address the real needs of European SMEs and industry, notably newcomers , established in the MS and AC with a view on  stimulating, encouraging and facilitating a more effective participation of European companies into the several funding opportunities included in Horizon 2020.


**Keywords:** National Contact Points, Innovation in SMEs, Access to risk Finance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Functional diversity in marine biogeochemistry: a combined approach using fluorescent and isotopic tracers for the quantification of silica deposition by individual diatom cells'.

assistant: **Innovation**

DIATRACK aims to enable the quantification of a biogenic element flux at the individual species level and thus understand the complex nutrient control of diatom (algae) abundance and hence, the ability of marine populations to modulate global warming. The principal objective is to develop a methodology to estimate individual cellular activity among diatom species and utilisation of silicic acid by natural diatom communities. This novel application brings together isotopic methods used to quantify silicon fluxes and the use of fluorescent tracers of silica cell deposition with diatom taxonomy and image analysis. We expect our methods will become standards for assessing the variability of cell specific activities in natural communities. Our observations and experimentation will be conducted in cooperation with oceano-graphical cruises (PROOF/KEOPS, PNEC/MEDOC).We intend to improve our understanding of phytoplankton community dynamics and provide new parameterisations for the new generation biogeochemical models (e.g. Dynamic Green Ocean Model of the Max-PlanckInstitute). DIATRACK is an innovative combination of specialty expertise from two disciplines - taxonomic ecology and isotope geochemistry, an innovation in line with multidisciplinary goals and recommendations of IMBER (Integrated Marine Biogeochemistry and Ecosystem Research), JGOFS(Joint Global Ocean Flux Study), European Network of Excellence EUR-OCEANS, and CNRS PROOF (PROcessus biogeochimiques dans l'Ocean et Flux).DIATRACK addresses a top priority in FP6: sub-priority area 1.1.6.3 Global Change and ecosystems (FP6-2003-Global-2, 30 June, 2003) and will foster international co-operation within the Science and Technology Agreement signed between the European Union and Australia. DIATRACK supports the main object
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Exploring the shell structure of exotic Sn isotopes with an Active Target'.

assistant: **Objectives**

The MagicTin proposal aims at the use of a new generation active target detector (ACTAR) to study the shell evolution in exotic Sn isotopes. The goal of this project is to commission the ACTAR demonstrator, optimizing it for the neutron-rich beams produced at the forthcoming second generation radioactive ion beam facilities.Worldwide, the availability of exotic ion beams is providing new insight on the evolution of nuclear shells far from beta stability, advancing our understanding of the nuclear force. Measuring transfer reactions, in particular 134Sn(d,p)135Sn, will allow to search for signatures of the existence of a new sub-shell closure at N=90 and to study, in this very neutron-rich region, the nucleon-nucleon interaction in the nuclear medium coupled to the continuum.Experiments where conventional techniques cannot be employed due to low-beam intensities will become feasible using the ACTAR device. This consists of a time projection chamber where the gas is used both as target material and as reaction products detector. Thanks to the fact that the interaction point lies inside the gas volume, very low detection thresholds can be obtained. Detection efficiency is also remarkably improved and this is essential when dealing with low intensity exotic beams.The beneficiary institution is deeply involved in the ACTAR development and the supervisor is managing an ERC project that aims at coupling ACTAR with gamma-ray detectors. Through the MagicTin project, the experienced researcher will have the possibility to learn the ACTAR technology, deeply contributing to the setup of the device for the exotic Sn physics case. Moreover, the experienced researcher (ER) will exploit his experience on scintillators to contribute in the development of the gamma-ray detectors. The ER
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Kits for advanced polymer-lipid nanocarriers for targeted delivery of RNAs to cardiac and skeletal muscle cells'.

assistant: **Objectives**

Currently, RNA therapies are available on the clinics to treat liver diseases and as COVID-19 vaccines. Hence, their therapeutic potential still remains largely unexploited for the treatment of other disorders, such as age-related, rare genetic and infectious diseases. One key problem for effective preclinical research on new RNA therapies is the lack of safe, efficient and cell-specific delivery vehicles. Gold-standard cationic lipid transfection reagents suffer from dose-dependent cytotoxicity, inability for cell-targeted delivery and poor stability. Clinically approved lipid nanoparticles efficiently target liver cells, while attempts to target other cell types have achieved limited success. In POLIRNA I will develop and validate a new safe, efficient, and versatile platform for RNA release to target multiple cell types, based on ligand-functionalized polymer-lipid nanocarriers, by exploiting a new patented method from my ERC-funded project BIORECAR (772168). POLIRNA consists of “kits for research use”, allowing user-friendly preparation of nanocarriers able to effectively deliver non-coding RNAs (such as siRNAs and microRNAs) to target cardiomyocytes and skeletal muscle cells for preclinical research studies on cardiac regenerative medicine and muscle-related diseases (e.g., neuromuscular diseases). Technology development and validation will benefit from collaboration with major experts in the fields and companies supporting the innovation route from lab-to-market. My previous experience as coordinator of research and innovation projects and as co-founding member of an academic spin-off company, and the current involvement of my team in business plan competitions will drive the process of technology validation, with the aim to strengthen technology value proposition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Accelerating transport electrification by machine learning' (ATEM) targeting Horizon 2020.

assistant: **Abstract**

The technological blossom in artificial intelligence (AI) makes possible numerous advancements in various engineering disciplines. The applicant has been in the forefront of this AI innovation, and received seven world prizes in AI competitions. For this fellowship, he intends to use his AI expertise to examine the role that AI technologies can play in accelerating transport electrification, and subsequently contributing to climate action. In view of the strong vehicle industry in Gothenburg, Sweden, Chalmers and Scania AB collectively provide an outstanding research environment for this important topic. More specifically, this project will consolidate data-driven electrochemical battery model, deep reinforcement learning based automated electric vehicle (AEV) speed control and AEV personalized routing recommendation model, which are three biggest challenges in the transition process towards electrified transport systems. The fellowship will be co-supported by AI Innovation of Sweden, and Drive Sweden, with a hope to implement the expected findings in not only the vehicle industry but also transport management sectors. This research is interdisciplinary in nature, and requires expertise from computer science, artificial intelligence, electrochemical engineering, electrical engineering, and transport engineering. In this regard, the host institute, Chalmers University of Technology, has developed a well-designed career training and development plan for the applicant to work with renowned research leaders in relevant disciplines (e.g. Prof. Xiaobo Qu, Member of Academia Europaea; Prof. Karl Johansson, Fellow of Royal Swedish Academy of Engineering Sciences) to enhance his readiness to become an assistant professor after this fellowship. The applicant will also take advant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Firms’ Social Impact:  Balancing Profits and Externalities' in the context of a Horizon Europe call.

assistant: **Objectives**

Firms conFirms contribute to society not only through profit-oriented activities such as innovation and job creation, but also by engaging in “altruistic” behavior by prioritizing broader social objectives, such as reducing pollution, improving labor conditions, and other pressing social issues. While economic theory suggests that externalities can be addressed through government interventions like taxes or property rights, incomplete information or political challenges often hamper these approaches. As a result, stakeholders must negotiate with firms, playing a key role in determining their social impact. Despite the importance of these negotiations, we know little about what drives them or how they influence a firm’s objectives. BALANCE breaks new ground both theoretically and empirically to assess how firms impact society and the underlying mechanisms.BALANCE’s overarching goal is achieved through four interrelated projects, each addressing distinct frictions that hinder stakeholders from demanding change. Project 1 examines prosocial banks, revealing how their entry affects borrowers’ productivity and long-term local economic growth. Project 2 examines how competition interacts with social impact—either differentiating a firm’s products or reducing its profit margins. Project 3 tackles information frictions in financial markets, where shareholders often lack awareness of whether others share their views on a firm’s green stance, potentially undermining coordinated efforts. Project 4 investigates information asymmetries in global value chains, where competitive pressures and opaque green certifications can lead to biodiversity loss.By integrating industrial organization and trade models with insights from finance and strategy, BALANCE pushes the research frontier whi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Superslippery Liquid-Repellent Surfaces'.

assistant: **Concept**

I aim to progress substantially the understanding and applications of extremely non-wetting surfaces, tying together basic research and attractive technological advancements. The first part focuses on robust synthesis methods for superslippery liquid-repellent (SS-LR) surfaces. Furthermore, using new types of ultrasensitive force measurement for droplets, I will investigate in depth the dissipation dynamics of mobile water droplets and adhesion of droplets to surfaces, to promote understanding on low-friction surfaces. The second part aims at applying these SS-LR surfaces in droplet actuation with potential to outperform existing technologies. Additionally, the potential of SS-LR surfaces for anti-icing and for preventing bio-fouling will be investigated. The research results will have a major impact on liquid-repellent technology and will explore the fundamental physical limits of non-wetting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'HArmonised environmental Indicators for pesticide Risk (HAIR)' under Sixth Framework.

assistant: **Concept**

This project will support Community policies for sustainable agriculture by providing a harmonised European approach for indicators of the overall risk of pesticides. It will integrate European scientific expertise on the use, emissions, environmental fate, and the impact of pesticides on agro-ecosystems and human health, in order to develop improved indicators which address the limitations of existing approaches. The main deliverable of the project is a set of harmonised environmental and human health risk indicators, provided in an easy to use software package. The proposed tool will include methods to predict environmental fate and exposure, and the resulting acute and chronic risks for aquatic and terrestrial organisms, for groundwater, for public health and for applicators of the pesticides. Consistent database structures will be developed for soil, climate, land use, agricultural practice, pesticide use and ecotoxicological data, to enable harmonised use of the indicators by all EU member states and candidate states. State-of-the art methods will be used to extrapolate from test animals to humans and wildlife, and the indicators will include chronic risks based on sub-lethal effects as well as acute risks. The project will use existing datasets to systematically evaluate the validation status of the indicators, including information gathered by regional and national organisations. The indicator outputs will be available on different scales, providing high resolution results at the catchment/regional level, taking account of local conditions of soil, climate etc; and also aggregated and integrated results at the European level. The indicators will provide new and powerful assessment tools for monitoring and managing the overall risks of pesticides. This will contri