RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'EU Fusion for ITER Applications' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

ITER is the next generation of fusion devices and is intended to demonstrate the scientific and technical feasibility of fusion as a sustainable energy source for the future. To exploit the full potential of the device and to guarantee optimal operation for the device a high degree of physics modelling and simulation is needed already in the current construction phase of the ITER project. First principles modelling tools that are needed for an adequate description of the underlying physics cover both a wide range of timescales and spatial orderings and are in general very demanding from a computational point of view. Current modelling activities relies on local or national computational resources and an improved access to computing infrastructures will be instrumental in advancing a pan-European modelling activity for ITER to a very competitive status in relation to the ITER partners.  <br/>The EUFORIA project will provide a comprehensive framework and infrastructure for core and edge transport and turbulence simulation, linking grid and High Performance Computing (HPC), to the fusion modelling community. <br/>The project will enhance the modelling capabilities for ITER and DEMO sized plasmas through the adaptation, optimization and integration of a set of critical applications for edge and core transport modelling targeting different computing paradigms as needed (serial and parallel grid computing and HPC).  Deployment of both a grid service and a High Performance computing services are essential to the project. A novel aspect is the dynamic coupling and integration of codes and applications running on a set of heterogeneous platforms into a single coupled framework through a workflow engine a mechanism needed to provide the necessary level integration in the physics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transforming Education for Democracy through Aesthetic and Embodied Learning, Responsive Pedagogies and Democracy-as-becoming' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Democracy is a lived experience. To flourish, democracy needs healthy roots in people’s engaged feelings, awareness and sensibilities as embodied beings connected with each other and their localities, communities and the natural world. Democracy cannot be understood and enacted simply through cognitive learning or technical interactive skills. Yet, education for democracy gives little attention to nurturing those aesthetic, affective and embodied roots of democracy. This is because the learning theory on which most education for democracy is based omits a fundamental dimension of learning – that is, the aesthetic and embodied nature of learning. The ambition of this project is to remedy this omission.The project will:- design an innovative, evidence-based aesthetic and embodied pedagogical framework which has an impact on the practice of education for democracy through associated guides to practice (toolkits) that support responsive, participatory pedagogies- test, through participatory action research, a prototype of the framework and guides in differing phases of education and national contexts- refine the framework and guides- disseminate and activate exploitation of the pedagogical framework and guides by ‘trailblazer users’.   The project’s scientific impact will be achieved through groundbreaking, transdisciplinary research that shows how aesthetic and embodied learning and responsive pedagogies for democracy facilitate new ways of ‘seeing’ and exploring self and others, enabling truly democratic relations and nurturing predispositions and capabilities for active democratic citizenship and deepening democracy.Societal impact will be achieved through new pedagogical approaches that engage learners’ and educators’ hearts as well as minds, increase capacity for democ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Translating fundamental insights in endothelial metabolism: PFKFB3 drug discovery and development' (PFKFBLOCK), addressing dissemination and exploitation.

assistant: **Impact**

Angiogenesis, the growth of new blood vessels, contributes to major pathologies such as blinding ocular disease, inflammation and cancer. Blocking angiogenesis has therefore become a major field of research and an attractive therapeutic strategy. Current anti-angiogenic therapies focus on blockade of pro-angiogenic factors, such as VEGF. However, in cancer, insufficient efficacy, resistance and toxicity restrict the success of anti-VEGF agents. There is thus an urgent unmet need for novel anti-angiogenic strategies. In our ERC Advanced research grant (ECMetabolism), we developed an entirely novel anti-angiogenic concept and strategy, based on targeting key metabolic pathways in endothelial cells (ECs), cells lining blood vessels. More in particular, we identified - for the first time - that PFKFB3, a key glycolytic regulator, as a novel and promising target for anti-angiogenic therapy. Our findings show that glucose metabolism determines vessel sprouting and that lowering glycolysis only partially and transiently (by blocking PFKFB3) sufficed to inhibit pathological angiogenesis without causing systemic effects. In this ERC proof of concept project, PFKFBLOCK, we aim to develop lead small molecule compounds, blocking PFKFB3, and evaluate their potential to block pathological angiogenesis. Currently, no specific and orally available PFKFB3 blocker exists underscoring the value of our proposal and the necessity to develop such blocker for therapeutic applications. Through collaboration with a drug discovery unit we will identify lead molecules with novel intellectual property potential. Those lead compounds will be validated in relevant in vivo models and considered to be patented. The ultimate goal of this project is to get the best PFKFB3 inhibitor in clinical trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Photonic Quantum Computer' (EPIQUE) targeting Horizon Europe.

assistant: **Abstract**

Photonics is one of the first platforms explored for quantum computing (QC), bringing the advantage of low decoherence and natural connectivity for distributed and blind QC. Recent years have witnessed a step-change in the scale, complexity, and scope of QC with photons which recently led to 3 out of the 4 demonstrations of quantum advantage from Canadian and Chinese groups. These impressive achievements were obtained with squeezed light in bulky apparatus that are not fit for scalability. Europe shows strong leadership in development of integrated optical QC platforms, with breakthroughs in the development of high transmission dense photonic chips, record efficiency detectors and deterministic single photon sources. Photonic QC also benefits from a clear roadmap toward fault tolerant architectures proposed by leading EU quantum algorithm teams. EPIQUE gathers world leaders in photonics QC with expertise in both technology and algorithms from academia and SMEs who work together to deliver the technological breakthroughs required to push the platform toward general purpose QC. This will be achieved via new nanofabrication that combines novel switching with mature silicon compatible circuitry, via optimising both single photon sources and detectors, via new interfacing possibilities in silicon nitride and direct write modular chips, via fast low loss switching in lithium niobate, and via quantum architectures that leverage all of these advances. EPIQUE will develop three QC prototypes that will demonstrate essential building blocks of generating and fusing quantum states to entangle >10 qubits, and critical measurement and feedforward capabilities required to scale the platform to >1000 qubits. At the end of this project, we will have proven a route to general purpose qua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a cost effective system for exchanging information and managing risks of chemicals for the construction industry, addressing new challenges related to European chemical legislation' (CHEMXCHANGE), addressing dissemination and exploitation.

assistant: **Impact**

This proposal addresses the great challenge faced by the SMEs in the construction sector of complying with today’s obligations and regulatory requirements regarding exchange of information on hazardous chemicals between various actors in the sector. The European construction sector, being the largest industrial sector highly dominated by small enterprises, is a major downstream user of chemicals and chemical-containing articles, including hazardous and particularly high-risk substances. Chemical safety at the working place represents a significant management burden for the construction companies and SMEs in particular, lacking knowledge, resources and systems for proper required chemical management. The most significant problem identified by the sector itself, is the lack of proper high-quality chemical risk information on the building sites, and low quality of safety data sheets (SDS) in particular. SDS is the major tool for hazard communication down the chemical supply chain to the end users and urgently needed to carry out legally required chemical risk assessment and risk reduction measures. The proposed ChemXchange chemical information exchange system seeks to fulfil the acute needs of the European construction sector regarding legal compliance particularly relevant due to the newly introduced European chemical legislation REACH, including challenges connected with chemical risk assessment, chemical communication up- and down the supply chain as well as and chemical management. Through a common sector-driven electronical chemical information system, the project seeks to solve all practical and judicial problems related to regulatory compliance as well as offering the sector a complete adapted business solution for total quality chemical management which does not ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'How Artifacts Acquire Agency: Towards a Philosophy of Automation'.

assistant: **Concept**

The proposed project brings together the applicant, a promising early career researcher (Mark Thomas Young) with a prolific and internationally renowned supervisor (Mark Coeckelbergh), hosted by one of the foremost centers for the philosophy of technology in Europe (University of Vienna). The primary objective is to develop a new philosophical approach to the study of automation that challenges dominant conceptions of automation as technologies that operate without human involvement by highlighting the wide variety of ongoing skillful practices upon which they depend. Drawing on perspectives from feminist studies of technology, the project will (1) identify the different forms of human agency upon which automating technologies depend, (2) explore the processes by which they come to be hidden from view and finally (3) examine the ethical concerns surrounding their erasure. In addition to making a substantial contribution to existing literature on automation in the philosophy of technology, the theoretical approach this project develops will also be useful for historical and sociological studies of technology alongside designers interested in the social impacts of automating technologies. By proposing a novel conception of automation which is useful across disciplines, this research addresses the secondary objective of this project; to establish the project manager as a leading voice in the philosophy of technology and to provide him training and experience that will enable him to attain his long-term career goal of a permanent position in philosophy. In addition to disseminating research results through the production of articles, a journal special issue and the organization of academic events on the theme of automation, this project will also utilize forms of public out
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Thin Monocrystalline silicon solar Cells and Modules' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

PROJECT OBJECTIVES The objective is to demonstrate theoretically and experimentally that in a silicon solar cell both maximum cell efficiency and lowest manufacturing costs can be achieved for wafer thicknesses between 100 and 150 Mm. This has benefit in lowering the cost of modules by having simultaneously a high module power and low manufacturing costs due to the use of thin silicon wafers and balance of system costs are also reduced. TECHNICAL APPROACH The project starts by modelling solar cell structures to define the ideal combination of wafer thickness, resistivity, minority carrier diffusion length and surface passivation for the highest efficiency. This modelling will be consistent with known parameters achievable from available processing techniques. Having defined the desirable solar cell structure the project is directed at realising these structures. The following sequence will be followed WP1 Solar Cell Modelling WP2 Preparation of substrates WP3 Solar Cell Development WP4 Module development and testing Wire sawing will be used to cut the thin wafers and the PERC cell structure will form a basis for the solar cell development. EXPECTED ACHIEVEMENTS AND EXPLOITATION The expected outcomes are higher efficiency solar cells than present and a much lower utilisation of silicon around 50% less than that previously used. This should result in technological leadership for the participant companies giving lower production costs superior products and a significantly increased market. The specific targets are to demonstrate laboratory solar cells of 4 cm2 area with efficiencies of >18% and in solar cells made under production conditions >17 % efficiency on a 100cm2, both on wafers thinner than 150 um.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of mammary epithelial morphogenesis by microtubule plus-end tracking proteins' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The mammary gland functional unit develops as a result of a complex morphogenetic process organizing polarized epithelial cells into a branched network of ducts terminating in acini. Most of human breast cancers originate from transformation of epithelial cells and induce breakdown of this structure. Studies in cells grown in two-dimensional (2D) cultures have shown that microtubules target and regulate actin network and adhesion complexes, which are also known to be essential components of three-dimensional (3D) tissue architecture. Here, I propose to address microtubule functions and behavior in a more relevant system to model physiological morphogenesis. For this purpose, I intend to investigate mechanisms underlying the regulation of microtubule dynamics and their biological impact in an in vitro reconstituted acinar model of untransformed mammary epithelial cells grown in 3D. My project aims at addressing the role of the growing family of microtubule plus-end tracking proteins (+TIPs) in the control of microtubule functions during 3D mammary epithelial morphogenesis. Special focus will be given to +TIP-dependent microtubule cross-talk with key structural components of acinar architecture. Imaging of microtubules in 3D mammary epithelial culture will be used to analyze microtubule behavior during epithelial-mesenchymal transition and the role of +TIPs in this process.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multimodal nanoparticles for structural and functional tracking of stem cell therapy on muscle regeneration' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cell therapy offers promising opportunities to approach several diseases for which no effective therapies are currently available. However, the prognosis of the treatment efficacy commonly only relies on the progression of the disease symptoms. There is a need of tools to evaluate and predict the safety and success of cell-based treatments in earlier stages. The current lack of methods providing real-time tracking of transplanted cells and knowledge on their early biodistribution and viability, is one of the major weakness of the available cell-based treatments.The main goal of nTRACK is to develop a safe and highly sensitive multimodal nanoimaging agent enabling noninvasive, quantitative and longitudinal stem cell tracking and whole body biodistribution. nTRACK will also provide information on cell (long-term) viability using the combination of CT, MRI and PET, which are imaging modalities that are clinically available. The synthesis of nTRACK NPs and cellular labeling processes will be scaled up and will follow good manufacturing practice (GMP) requirements. A second goal is to establish a predictive model for early assessment of treatment effectiveness, based on short-term evaluation of the typical migration and biodistribution patterns of the stem cells. This predictive model could substantially improve overall management of the disease and will transform cell therapy treatment from “one size fits all’ concept towards personalised treatment. The nTRACK technology will be demonstrated on a muscular injury sheep model, using imaging infrastructure commonly used in hospital settings. In addition, non-clinical safety studies on the nTRACK nanoparticles will be conducted following the conclusions of a series of formal interactions with regulatory authorities, to allow th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Non-Invasive Chemistry Imaging in the whole human body' under Horizon 2020.

assistant: **Concept**

The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body. Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.Breakthroughs: I. Methodology for the discovery of discriminative  biomarkers and II. Technological platform for full body biochemical imaging. Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding. Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging. Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its p