RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'From capture based to SELF-sustained aquaculture and Domestication Of bluefin tuna, Thunnus thynnus' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

SELFDOTT proposes to implement knowledge already obtained on the artificial control of reproduction of the Atlantic bluefin tuna (BFT), Thunnus thynnus, to obtain viable eggs, and study embryonic and larval development for the production of fry (juveniles). At the same time, suitable and environmentally performing feeds for the growout of BFT will be developed, thus reducing or eliminating the practice of raw fish importation and feeding by the fattening industry. Wild juvenile and mature BFT will be reared in captivity at two sites in the Mediterranean, and will be used to study puberty, gametogenesis, and the influence of diet on reproductive maturation and gamete quality. Mature fish will be induced to spawn using hormone implants and the eggs will be collected using devices designed specifically for cages. To establish the knowledge-base for controlled development of BFT larvae, the mesocosm and artificial larval rearing methods will be employed. The ontogenesis of essential biological functions will be studied, including environmental perception, digestion, immunity and behaviour. A protocol for the commercial-scale larval rearing of BFT will be recommended at the end of the project. Whole body and stomach composition of wild fish will be analyzed and serve as a guide to formulate nutritionally complete artificial feeds for BFT. Juveniles will be captured from the wild, adapted to captive conditions and used to carry out weaning and feeding experiments, using moist and dry pelleted diets. The environmental impact of the formulated feeds will be examined and compared to existing raw-fish practises. SELFDOTT will produce the basic knowledge necessary for the development of a self-sustained aquaculture industry for the BFT in the Mediterranean, thus enhancing the comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Investigation of phosphorus dynamics and microbial linkages for managed soil development' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Low P-availability in soils, soil degradation, over-application of P fertiliser and gradual depletion of P-resources are a threat for the sustainability of future agricultural production. Within soils, microorganisms play an active role in the cycling of P by: 1) storing P within their biomass, 2) mineralising non-plant available organic P, and 3) solubilising inorganic P forms . They are thus a key driver in the cycling of P in soil, both in shortterm (e.g. over a growing season), and in longer term, governing changes in soil P pools as soils develop. Greater insights in soil microorganisms’ role in cycling P in soil as a function of soil age, properties and management would create new opportunities for developing more sustainableagricultural systems that make better use of P, whilst simultaneously preventing losses to the environment. In this project  I will investigate the interactions between soil P, soil microorganisms, and soil characteristics that promote microbial P cycling and P availability to plants along a managed soil chronosequence (Industrial partner: Inden mine, RWE Power AG, Germany (RWE)). The site represents a unique opportunity to study P dynamics under the effect of management practices and microbial processes over time. I will use state-of-the-art methods (e.g. isotopic and spectromicroscopic techniques) to deliver a better understanding of how soil microorganisms can regulate P availability in soil. I will address the following scientific question: How do soil properties, management and time affect P dynamics driven by soil microorganisms? I will carry out the research at the University of Copenhagen (Denmark) at the Department of Geosciences and Natural Resource Management (IGN), under the guidance of Assoc. Prof. Carsten Müller; and I will under
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of novel treatment strategies based on knowledge of cellular dysfunction in diabetes' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

A reduction in functional pancreatic beta cell mass is the key feature of type 1 and type 2 diabetes. Beta cell failure is exacerbated in the context of obesity and insulin resistance. Brown adipose tissue (BAT) is a highly metabolic organ, mediating energy dissipation and glucose disposal, thus contributing to maintain energy balance. BAT dysfunction contributes to obesity and impaired glucose metabolism, increasing functional demand on the beta cells. The cellular dysfunction of beta cells and BAT in diabetes is the fruit of defective signal transduction and organelle function, and the vulnerability to these molecular defects may be modulated by diabetes genes. To identify the crosstalk and pathways responsible for beta cell and BAT dysfunction and beta cell apoptosis in diabetes at its real level of complexity, this consortium will use cutting edge genetics, functional (epi)genomics, molecular biology and computational tools to reach an accurate organelle and cell diagnosis. This diagnosis will be used to define novel targets for intervention to prevent dysfunction and facilitate recovery of functionally impaired metabolic tissues. Some of these targets have already been identified by consortium members, including endoplasmic reticulum (ER) stress and mitochondrial dysfunction and apoptosis. Since many of these targets are related to dysfunction of specific organelles, we will focus on the novel concept of organelle therapy, aiming to preserve mitochondrial and ER function by the use of viral vectors and small molecule chemical probes. We will thus follow a two-pronged approach, namely a focused approach to restore known and specific cellular/organelle dysfunctions and a systems biology approach to identify novel targets for intervention. This, in combination with hi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Nutrient sensing and signaling by the yeast Gap1 amino acid transceptor' (2007-2013).

assistant: **Innovation**

The proposal aims the reintegration of a senior post-doctoral researcher of Spanish nationality, Dr. Marta Rubio-Texeira, now working at the Whitehead Institute (MIT, Cambridge, MA, USA), into the European research area at VIB/KULeuven in Belgium. Dr. Rubio-Texeira has advanced knowledge and extensive technical know-how on molecular mechanisms involved in plasma membrane protein trafficking and internalization in yeast, in the use of yeast as a tool to study proteins involved in neurodegenerative diseases and in the biotechnology of lactose fermentation. She will be integrated into the VIB department of Molecular Microbiology, located at the KULeuven, as a senior post-doctoral researcher, with committed support of the FWO Flanders for her initial appointment. With her experience she will strenghten the world leading research at this department into the molecular genetics and biochemistry of nutrient sensing and signaling in yeast. She will concentrate her work on the functioning of Gap1, an amino acid transporter that also functions as an amino acid sensor for activation of the protein kinase A (PKA) pathway in yeast. Gap1 is the best established example in eukaryotic cell biology of an actively transporting nutrient carrier that also functions as a receptor protein (‘transceptor’). She will investigate the relationship between Gap1 mediated amino acid activation of the PKA pathway and the rapid amino acid induced downregulation of Gap1 by dephosphorylation, ubiquitination, internalization and degradation. The latter is reminiscent of ligand-induced downregulation that occurs in many classical receptor proteins. In the second part of her work she will focus on elucidation of the components in the signaling pathway between Gap1 and PKA. The research on yeast nutrient sen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Silicon based materials and new processing technologies for improved lithium-ion batteries' (SINTBAT).

assistant: **Concept**

According to the European Energy Storage Technology Development Roadmap towards 2030 (EASE/EERA) energy storage will be of the greatest importance for the European climate energy objectives. The Sintbat project aims at the development of a cheap energy efficient and effectively maintenance free lithium-ion based energy storage system offering in-service time of 20 to 25 years. Insights gained from advanced in-situ and in-operando analysis methods will be used for multi scale modelling targeting on the simulation of aging mechanisms for a reliable lifetime prediction and enhancement. In addition, the latest generation of anode materials based on silicon as well as a prelithiation process for lifetime enhancement will be implemented in the cell manufacturing process. The implementation of high energy materials combined with a low cost and environmental benign aqueous cathode manufacturing process will lead to remarkable cell costs reduction down to 130 € per kWh. This will enable battery based storage system for an economic reasonable price of less than 400 € per kWh (CAPEX) and will lower the OPEX down to less than 0.09 € per stored kWh for the targeted in-service time of 20 to 25 years (10,000 cycles). The technical developments will be supported by the set-up of a relevant roadmap as well as a catalogue for good practice. To guarantee the highest possible impact for the European economy the Sinbat consortium installed an Industrial Advisory Board including various European battery material suppliers, cell manufacturer and end-users whereby the whole value added chain in this way is completed within the Sintbat project. This strong interaction of the Sintbat consortium with relevant stakeholders in the European energy economy will assure that battery based energy storag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'ARGONAUTE proteins transport routes and subcelular activities'.

assistant: **Innovation**

Small RNAs (sRNA) have emerged as major players in a multitude of pathways, controlling development and preserving genome integrity in plant and animals. To fulfill their biological function, sRNA are loaded into ARGONAUTE (AGO) proteins, together this AGO/sRNA complex recognizes and regulates the target genes. Depending on the organism and the sRNA pathway involved, AGOs have nuclear and/or the cytoplasmic localization and functions. Although globally AGO mediated processes are reasonably understood, the transport routes involved, their shuttling regulation and transient subcellular roles remain completely unknown. This proposal outlines a series of mutually reinforcing experiments to mechanistically study the transport routes and subcellular roles of AGO-sRNA complexes. In details, combining cell biology, RNA biochemistry, protein modeling, bioinformatics, deep-sequencing analyses, nuclear fractionation methods and single-molecule studies the proposed project aims to: 1) Identify key subcellular localization signals of AGO proteins; 2) Decipher AGO shuttling mechanism and their regulation; and 3) Dissect cytoplasmic and nuclear roles of AGO proteins on RNA pathways. The anticipated results will provide a crucial breakthrough in the eukaryotic RNA pathways and gene regulation fields. The interest in non-coding RNA action goes beyond mere mechanistic knowledge. Understanding non-coding RNA action is of paramount importance given the extraordinary potential held by the therapeutic, veterinary and agronomic exploitation of these molecules. As a result, the knowledge on the transport routes and subcellular roles of AGO-sRNA complexes obtained during the proposed project will provide an important contribution to European excellence and competitiveness in the field.


**Keyw
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Walking towards an European regionally based research area on new processes and flexible intelligent manufacturing systems' (MANUNET) targeting Sixth Framework.

assistant: **Abstract**

Manufacturing is a key economical activity in Europe, with a turnover of 4,300 B, representing the 31.5 % of the total added value generated and offering 40 million direct jobs. But manufacturing is at risk in Europe and its competitiveness sits on innovation and r+d. National and European programs have increased their requests towards more technology driven targets (new functional materials, nanotechnologies), while short to mid term objectives of many manufacturing sectorial needs have been attended by Regional research programs, playing the role of near to industry", specially in those numerous cases where sectors are highly concentrated in particular European poles. But the fragmentation of research at this regional level is significant, and little has been done to realize the "regional dimension of ERA (Com 2001-549)". Said that, MANUNET Coordination Action, based on the results of MANUNET SSA, tackles the challenge of supporting the building up of the European Research Area on Manufacturing, mainly based on a regional structure, with the following strategic objectives:(1) Execution of two Common Call for Proposals for Research in Manufacturing, open to 22 European Regions, as the key contribution from MANUNET to ERA(2)Durable cooperation by means of the execution of the MANUNET model of yearly Coordinated Calls, in an evolutionary path that will also benefit from the extended opportunities in FP7 (ERA-NET-PLUS)(3)Coordination with other European R&D support initiatives in Manufacturing, from the Technology Platforms side (emphasis in MANUFUTURE) and other instruments ( Eranets, MNP area of FP6/7)(4)Mutual enrichment of the regional/national R&D support programmes by fruitful interchange of experiences(5)Enlargement to 31 Regions, creating a notable platform to imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ion Mobility Mass Spectrometry Training Network' (MobiliTraIN).

assistant: **Concept**

Ion mobility-high resolution mass spectrometry (IM-HRMS) is the next-generation analytical platform in research and industry. Unlocking its full potential across applications as varied as biotherapeutics, environment and food safety requires not only pushing back the frontiers of instrumentation, fundamental understanding and applications – but harmonisation is essential. To achieve this, current shortcomings in data collection, analysis and reporting across instrument types, laboratories and research areas need to be scrutinised and overcome. The MobiliTraIN Doctoral Network will form 13 Doctoral Candidates (DCs) who will bring a new fundamental understanding of IM-HRMS, provide reference materials and guidelines for standardisation, develop state-of-the-art methods for the application of IM-HRMS in biopharmaceutical development, biological ‘omics studies, and nontarget screening of contaminants, and lay the foundations for IM-HRMS adoption in industry. Through an interdisciplinary research programme, including an open science approach and training in technical, business and transferable skills, the MobiliTraIN DCs will become leading experts in ion mobility with a unique skill set to successfully advance their careers while supporting Europe’s innovation capacity. Building on existing collaborations and research excellence covering the entire innovation chain of IM-HRMS development and application, MobiliTraIN unites 10 academic institutions, 3 leading instrumentation companies, 1 regulatory agency, 1 pharma industry leader and 5 SMEs from 8 countries. With complementary expertise, know-how and mentoring experience, our consortium is ideally suited to unveil the potential of IM-HRMS as a key technology for safer therapeutics, better understanding of complex disease pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'International congress of human genetics' (ICHG) targeting Fifth Framework.

assistant: **Abstract**

The International Congress on Human Genetics (ICHG) to be held on 15 to 19 May 2001 in Vienna by the European Society of Human Genetics on behalf of the International Federation of Human Genetics Societies (IFHGS) , will provide European Geneticists with a unique opportunity to host geneticists from all over the world, to benefit directly from their presence and to affirm the important role that human genetics plays and will play in Europe in science, in medicine and in industry. Through the present proposal fellowships will be offered to young scientists from economically deprived countries and information will be provided to the international community on the scientific and societal aspects of human genetics through preparatory press relations and an active press room.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Secure Data Processing in the Cloud', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Secure cloud computing is key for business success and end-user adoption of federated and decentralized cloud services and thus essential to stimulate the growth of the European Digital Single Market. RestAssured will provide solutions to specific technical concerns of data protection in the cloud (such as geo-location restrictions on personal data), which are imposed by the dynamic, multi-stakeholder and decentralized nature of federated cloud systems. These concerns mean that privacy and security by design approaches will no longer be sufficient, due to uncertainty at design time of how the cloud and privacy requirements may dynamically evolve and change at run time. To this end, RestAssured provides novel mechanisms and cloud architectures for the runtime detection, prediction and prevention of data protection violations. RestAssured will assure the protection of sensitive business and citizen data in the cloud by combining four pillars of innovation: (1) combination of fully homomorphic encryption to process data without decryption with cloud enablement of SGX hardware for protected data processing, (2) sticky policies for decentralized data lifecy-cle management, (3) models@runtime for data protection assurance, and (4) automated risk management for run-time data protection. The applicability and usefulness of the RestAssured solutions will be demonstrated through three use cases driven by project partners and involving other stakeholders from outside the consortium; High Performance Computing for commercial enterprises; Pay As You Drive usage based insurance; and self-directed Social care for vulnerable adults and social care providers. The main impact of RestAssured will be to enable the free and seamless movement of data within the EU, whilst assuring conformanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Phenomenological implications of supersymmetric models'.

assistant: **Concept**

Research objectives and content The research objective of the proposecl project is the study of the phenomenological implications of extensions of supersymmetric models at the col- lider machines. The moclels I will study include the minimal supersymmetric standard model with an aclditional gauge singlet models with an extra U(1) and superstring-derived models. I will study both the direct and indirect evidences of such models. As indirect evidences I will focus on the precise electroweak measurcments at LEP and SLC. I will compute the radiative corrections within these models and thell I ill compare ttlC electro eak data with ttle theoretical predictions studying how to discrilllinate betweell the arious mo(lels. For the direct searches at LEP 2 the Tevatron and LHC I will compute the cross sec- tion of production of the supersymmetric particles within the above models. Training content (objective benefit and expected impact) With the proposecl project I expect to acquire a lot of experience and a very good knowledge on superstring-deri ed models SIlSy models with e;tra U(1) and/or with extra gauge singlets. I t)elie e that thc collaboratioll with the re- search group in Paris will be a ery goocl opportunity to increase my knowledge o n this subject. Links with industry / industrial relevance (2 )