RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pluridisciplinary study for a RObust and sustainabLe Improvement of Fertility In Cows' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Intensive genetic selection in dairy cattle has resulted in a modern cows with very high milk yield but reduced fertility and poor calving performance. The sustainability of dairy cattle farming systems relies in large part on the ability of cows to maintain reproductive performance as they cope with the constraints imposed by environmental conditions and livestock practices.The strategic aim of this project is to unlock the potential for proactive herd management by providing the farmer with improved tools for on-farm reproductive monitoring and management. This will be achieved by a pluridisciplinary approach to eliminate the key scientific/methodological blockages and develop innovative solutions for a robust and sustainable improvement of fertility in cows. The project is structured in four R&D workpackages, one demonstration, one outreach and one management WP. The project will: 1) develop models to support on farm decision at different levels: animal fertility, herd management, and socio-economic impact for the farm and the farmer 2) identify genes and pathways involved in the adaptation of the reproductive function to different environmental conditions, especially low input feeding systems 3) identify the functional quantitative trait nucleotides for days till first luteal activity (based on progesterone measures) and estimate genomic breeding values using whole sequence information on individuals 4) study the adaptative response of animals to different feeding systems and management strategies 5) demonstrate the applicability of the knowledge and tools produced in the PROLIFIC project at the farm level 6) disseminate the knowledge produced in the project to the relevant stakeholders. PROLIFIC is a pluridisciplinary project taking advantage of the skills and expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and Control of Flexible Mode-locked Integrated Laser' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

This proposal aims at the development, characterization and control of a novel class of high repetition rate ultra-short pulse lasers featured by stable, flexibly shapeable emission properties combined in an integrated format (i.e. on chip). The associated benefits in terms of cost, size, and power consumption paired with the intrinsic flexibility are unquestionably significant characteristics to fulfil the dynamic needs of numerous sophisticated applications in the broad areas of metrology, telecommunications, microchip-computing etc., and will in turn enable to finally bring these innovative integrated lasers to the public market. By exploiting a high-Q microring resonator, a novel mode-locking approach named filter driven four-wave mixing (FD-FWM) will be used to achieve stable high-quality spectral emission. Enabled by this scheme, we will investigate and exploit the interesting effect of higher-order modulation instability dynamics (a higher-order characteristic of the mechanism responsible for laser mode-locking, not yet explored), to control and shape the emission as well as the noise properties of the proposed integrated laser device. In particular this will be achieved by dynamically controlling the main cavity dispersion of the system via incorporated specially designed Bragg grating waveguides. In parallel with the investigations on the controllability of the laser emission, the integration of the whole device will be pushed forward by designing and fabricating microring resonators based on silicon (oxy)nitrite technology as well as by developing a novel miniaturized laser scheme based on semiconductor optical amplifiers. The external optical control possibilities of the laser scheme proposed here will be exploited with a view to synchronize two lasers, a hig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Typical and Atypical structures in quantum theory' to be submitted under Horizon Europe.

assistant: **Abstract**

Quantum theory, confirmed in numerous sophisticated experiments, is widely believed to describe our world at the micro scale. It is thus legitimate to investigate, which structures are allowed by quantum theory, and which of them can potentially be relevant for developments of quantum technologies.The basic notion of a quantum state  a mathematical tool used to compute probabilities, characterizing the outcomes of a quantum measurement  is of a primary importance. Furthermore, one analyses quantum maps, which describe how quantum states evolve in time, and quantum supermaps, representing evolution in the space of quantum maps. Assuming that the number of outcomes is finite, all these sets form convex bodies embedded in a real space of a suitable dimension. The case, if the physical system is composed of several subsystems, is of a special interest, as one can analyse correlations and entanglement between subsystems.  Main goal of this project is to investigate properties of typical quantum states, maps and supermaps, and to identify distinguished, atypical structures with extreme properties, useful for processing of quantum information. We will search for new constructions of absolutely maximally entangled multipartite states, which imply existence of quantum error correcting codes, novel schemes of mutually unbiased bases and symmetric informationally complete generalized quantum measurements, which offer optimal measurement accuracy. Moreover, we plan to analyze quantum supermaps with distinguished properties, and study, how these structures behave under decoherence, as quantum features become gradually suppressed.To put all these structures of the same footing we are going to use generalizations of the Choi-Jamiokowski isomorphism, which relates quantum maps with qua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Distributed multimedia-archives for co-operative TV-production' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The field of application for the EUROMEDIA project represents the fusion of digital multimedia technology with broadcasting technology. A basic prerequisite for emerging broadcasting services such as Video on Demand (VoD) is the design of digital archives and the provision of suitable means for access them. Since digitised material intended for broadcasting, including relevant descriptive and administrative data, is multimedia in nature, the digital archives also need to be multimedia.The project addresses both the design of the archives and the development of suitable means for accessing them. It is developing a digital multimedia archive in the broadcasting domain. The project is characterised by:- Use of available technology.- Design and installation of multimedia archives with common access by the users involved in the consortium.- Application of suitable and advanced (semi)automated multimedia indexing and retrieval methods using image processing.- Interconnection of and data exchange between local components installed at the individual users' sites using available communications infrastructure.- Provision of interfaces to administration and production at the broadcasting sites involved.- Integration into the broadcasting workflow.- Analysis of service provision by applying the pilot system to the distribution of programmes among the users involved.The system will also provide mechanisms for the management of rights and remuneration. For coping with mass storage problems, most of the material will be kept in preview quality.The users involved are broadcasters who are participating in the EUROMEDIA consortium and other potential users of the archives.In addition to the broadcasting scenario described above, the generality of the system being developed will be valida
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Forwarding development of novel somatosensory testing equipment in humans' to be submitted under Horizon Europe.

assistant: **Abstract**

The SOMATOSENSE project aims to provide accurate, automated, and innovative tools to probe the human somatosensory afferent system and diagnose problems. Somatosensory information from the skin provides us with a continuous stream of information, to allow us to interact efficiently with the world and to ground us in our bodies. In somatosensory disorders, there can be issues with one or more types of sensory afferent that can cause debilitating effects, including pain. Currently, somatosensory clinical tests are often applied manually, can be painful, and may not be specific enough to make rapid diagnoses. This is a major and prevalent issue, where there are hundreds of millions of people across the world who suffer with somatosensory disorders, such as diabetic neuropathy, which can have complex origins. SOMATOSENSE aims to create efficient, non-painful tests of somatosensation that would be highly beneficial to the clinic and for fundamental research. This investigation is grounded in our in-depth knowledge and skills in somatosensory research and technology development. In two work packages (WPs), we will explore novel tests of somatosensory function, focusing on touch and including temperature mechanisms. In WP1, we will make four small, new devices that are easy-to-use, yet will accurately test different aspects of touch (e.g. the perception of brief touch, moving touch, airflow, and wetness). These will provide complex insights into somatosensory function and integration, which cannot easily be tested with existing technology. In WP2, we will develop a clinical microneurography system, where multiple direct axonal recordings can be gained from human peripheral nerves to provide exquisite insights into neuronal function in patients. These new devices will lead the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Role of Autophagy and Lysosomal Biogenesis in Hypoxia and Radiation-induced cell death in normal and cancer cells' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The aims of the project are to investigate, for the first time, the mechanisms and the role of autophagy and lysosomal biogenesis in hypoxia and radiation-induced cell death in normal and cancer cells. In project 1 we ask whether autophagy and lysosome biogenesis are involved in hypoxia and the acute and/or late toxicity of radiation in normal cells and tissues, and the eventual radioprotection that could be achieved by modifying process. We will study the direct effects of ionizing radiation and hypoxia on the autophagic pathway and lysosomal biogenesis in normal cell lines. Also, we will conduct a moderate-throughput siRNA screen of different autophagic variants and lysosomal biogenesis pathways in hypoxia and radiation in normal cells. Further, we will study the effects of ionizing radiation in liver conditional knockout or overexpressed mouse line of the master transcriptional regulator of autophagy and lysosomal biogenesis TFEB, and compare its radiation toxicity with the commercial available compound the amifostine. In project 2 we ask whether upregulation or downregulation of the autophagy and lysosomal biogenesis could enhance the radiation sensitivity in vitro and in vivo. We will identify mutants in fission yeast that are either protective from, or synergistic with ionizing radiation and link with autophagy and lysosomal biogenesis and will be further exam in breast cancer cell lines. We will conduct a moderate-throughput siRNA screen of different autophagic variants and lysosomal biogenesis pathways in radiation sensitivity in breast cancer cell lines. Also we will develop an inducible dox-shRNA for TFEB in a xenograft model and investigate the therapeutic value combined with radiation therapy. We anticipated to identify critical targets for pharmacological o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Artificial Motion Factory' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Todays robots are confined to tightly controlled environments: even the complex choreographies that the Atlas humanoid flawlessly executes heavily rely on handcrafted control strategies and detailed workspace models, with little place for sensing. To put it bluntly, robots are nowhere near the level of agility, dexterity, and even less so autonomy, robustness, and safety required for their deployment in the wild alongside people.The tenet of ARTIFACT is that the key to an actual revolution will come from the algorithmic foundations of artificial motion intelligence, an AI challenged from the start to interact physically with dynamic environments and, ultimately, people. To do so, we will break away from the dichotomy between optimal control, where the role of perception is traditionally limited to an early state estimation stage, and reinforcement learning, where control policies are typically learned model-free with no guarantee to cope with the curse of dimensionality.In ARTIFACT, we will devise a unified, structured, modular, and learnable control architecture for providing robots with advanced decision-making capabilities to solve complex tasks and face new interactions as they experience the world. It will leverage the notion of differentiable programming at all scales to enable robots to (i) capture models of their interactions directly from a sound combination of sensor data and first principles from physics, (ii) autonomously discover new complex gestures and movements leveraging their past experiences, and (iii) learn embodied representations to control their interactions finely and reason about the physical world. It will be implemented in open-source software and shown in real-world and challenging scenarios requiring fine dexterity and high agility. Altogeth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Clean and efficient cooling in vaccine transportation using Rotating Magnetocaloric Effect' (MAGCCINE).

assistant: **Concept**

Every year 1.5 million lives are lost worldwide due to insufficient access to vaccination while, paradoxically, over 50% of all produced vaccines are wasted, mostly due to ineffective temperature control during storage/transportation. The major challenges of the vaccine cold chain are the evermore strict limitations imposed on their aerial transport due to the safety hazards of refrigerant gases, the high-power demand of active refrigeration devices in last-mile deliveries where the electricity supply is unreliable, and the significant carbon footprint of high global warming potential refrigerants.The Magccine project aims to revolutionize the vaccine cold chain by developing a clean and efficient solid state magnetic refrigerator based on a novel approach: the rotating magnetocaloric effect (RMCE) – a recently (2023) patent pending technology by project partners. By reducing the amount of permanent magnets required, the RMCE is expected to enable drastic cuts in the device’s production cost, volume and weight, while enhancing efficiency without the use of any high GWP or hazardous refrigerant gases, highlighting its role as a key enabling technology for tackling vaccine cold chain challenges. Magccine´s goal is to develop and optimize a fully operational prototype for vaccine refrigeration in the 2-8 ºC temperature range, which is required by most vaccines, addressing the Generation of clean cooling and clean cold chain transportation categories of this Challenge.To this end, this project requires top-level expertise on magnetocaloric materials, magnetic field design, thermodynamic simulations and heat pumps which are perfectly matched by the complementary expertise of the five academic institutions (U.Porto, CNRS, U. Seville, U.Aveiro, U.Ljubljana) and the two industr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'PROTEIN TYROSINE PHOSPHATASES IN METABOLIC DISEASES: OXIDATION, DYSFUNCTION AND THERAPEUTIC POTENTIAL' in the context of a Horizon 2020 call.

assistant: **Objectives**

Diabetes mellitus is characterised by hyperglycaemia caused by an absolute or relative insulin deficiency. The global prevalence of diabetes has reached more than 410 million individuals, underscoring the need for novel therapeutic strategies targeting the pathology as a multi-organ disease. Protein tyrosine phosphatases (PTPs) constitute a superfamily of enzymes that dephosphorylate tyrosine-phosphorylated proteins and oppose the actions of protein tyrosine kinases. My previous studies and preliminary data suggest that PTPs act as molecular switches for key signalling events in the development of diabetes, i.e. insulin/glucose/cytokine signalling. Dysregulation of these pathways results in metabolic consequences that are cell-specific. Oxidative stress abrogates the nucleophilic properties of the PTP active site and induces conformational changes that inhibit PTP activity and prevent substrate-binding. I have recently developed an innovative proteomic approach to quantify PTP oxidation in vivo and demonstrated that this occurs in liver/pancreas under pathological conditions, including obesity and inflammation. In this proposal, I aim to fully characterise the activity and oxidation status of PTPs in dysfunctional metabolic relevant cells in obesity and diabetes. Importantly, the crucial role of PTPs make them promising candidates for the treatment of metabolic disorders. I hypothesise that specific antioxidants, diets and/or adenovirus will restore PTP function and ameliorate the metabolic deleterious defects in pre-clinical studies. Over the next 5 years, I aim to:• Identify the major oxidised PTPs in metabolic relevant tissues/cells in both obesity and diabetes.• Determine the contribution of PTP inactivation in cellular responses to metabolic signalling in human sam
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Evolvable and rapidly adaptable monobodies: a broad-spectrum antiviral platform' to be submitted under Horizon Europe.

assistant: **Abstract**

With progress in globalization, expansion of human populations into natural habitats, and aggravation of climate change comes an increased risk of viral outbreaks. As demonstrated by the COVID-19 pandemic, not being prepared for such events has devastating consequences on public health, society and the economy. EvaMobs will improve preparedness of the European Union (EU) for the next viral outbreak(s) of pandemic potential by developing a platform for the discovery, development, production and validation of evolvable and rapidly adaptable antivirals. These innovative medicines will be based on small human-derived proteins called monobodies (Mobs). As Mobs can be engineered to have high binding affinity for virtually any viral protein, this platform can be easily adapted to a broad range of viruses, including newly emerging viruses and viral variants.To demonstrate the capacity of this platform it will first be applied to four pathogenic viruses with epidemic and/or pandemic potential: Influenza A, SARS-CoV-2, respiratory syncytial virus, and Zika virus. Deep-learning and computational design tools will allow generation of tailor-made Mobs with cryo-EM elucidating the molecular details of their binding interaction. Simple bacterial expression of Mobs, the development of a semi-automated high-throughput screening platform for evaluation of the Mobs’ stability and target affinity and streamlined in vitro and in vivo preclinical validation, will allow rapid development and selection of stable and potently neutralizing candidates. The Mob with the best preclinical indicators will then be tested in a phase I clinical trial after implementing a stable formulation and GMP production. The optimized platform can then be adapted to other viruses. Therefore, EvaMobs provides an inn