RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Steady-state entanglement with superconducting qubits' in the context of a Seventh Framework call.

assistant: **Objectives**

Quantum entanglement is the key resource that makes quantum information-processing machines more powerful than classical ones. In this project in quantum-mechanical engineering with superconducting qubits – electronic circuits that are engineered “artificial atoms” – I will create quantum-entangled steady states that never decay, as long as the qubits are subject to external microwave drive fields. I will do this by designing the driving protocol and the qubits’ dissipative environment – “quantum bath engineering” – in a circuit-QED architecture with carefully designed qubit-resonator couplings and resonator loss rate. The dominating transition rate can then act to prepare the system, rapidly and with high fidelity, in the desired singlet as a steady state of the dissipative time evolution. This is a new concept: only very few related experiments have been done with other physical systems, and none with superconducting qubits. Compared to the standard way of preparing entangled states – by one- and two-qubit unitary gate operations – this scheme has several advantages, chiefly the resilience to energy relaxation of the qubits because the induced transitions and the relaxation processes bring the system back to the desired state.I already have preliminary and promising results in this project, and good international collaborations. The excellent infrastructure and great environment at Chalmers University will help me succeed, which in turn will ensure my integration into the European research community.This research field is internationally very competitive, in particular as superconducting qubits are emerging as the perhaps most viable type of system to base future quantum computers and quantum simulators on. It should therefore be a strategic interest for the EU to con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Flows of hot plasma connecting the Milky Way centre to the corona, halo and beyond'.

assistant: **Concept**

We are less than one year away from the beginning of a revolution in our understanding of the hot, X-ray emitting, plasma of the Milky Way. The growth of galaxies in the local Universe critically depends on the interplay (via outflows and re-condensation) between the hot plasma with the other phases of the interstellar medium (ISM). As a prototype for typical spiral galaxies, the Milky Way offers the unique opportunity to capture the important details of such feedback all the way from sub-parsec to galactic scales. In the 90's, the ROSAT all-sky X-ray maps confirmed the existence of a hot component of the ISM, the Galactic corona. However, because of strong obscuration in the soft X-ray energy band, those maps have a limited horizon of ~1 kpc in the Galactic plane. Therefore, despite the fundamental role of the hot ISM phase, its properties are still basically unknown outside the Solar neighbourhood.My XMM surveys of the Galactic centre (GC) demonstrate that the hot ISM phase can be traced throughout the disc in the harder X-ray band, confirming the feasibility of this ERC project and the strong connection between GC activity and the Galactic corona. Additionally, the hot plasma is a plausible candidate for containing the missing Galactic baryons and a key ingredient for galaxy evolution. However, so far only less than 0.03% of the Milky Way has been covered by the narrow fields of view of current X-ray imaging telescopes.The eROSITA all-sky survey will rectify this state of affairs. Should this ERC proposal be approved, we will trace the connection and feedback between the Galactic corona and halo with the energetic activity at the GC (e.g., due to cosmic rays, stellar and AGN outflows). This will represent one to two orders of magnitude improvement in sensitivity and/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Towards the discovery of efficient CO2 electroreduction catalysts: well-defined RuOx and MoSx nano catalysts'.

assistant: **Innovation**

In future, fuels and basic chemicals may be produced via an electrolytic process that converts CO2, water and electricity derived from renewable energy sources. Such promising, yet underdeveloped technology needs fundamental breakthroughs in the development of efficient electrode catalysts, i.e. electrocatalysts, for CO2 reduction reaction (CO2-RR). In fact, none of the currently known catalysts has adequate efficiency.In this project, I propose to investigate well-defined ruthenium oxide (RuOx) and molybdenum sulphide (MoSx) nano catalysts for the CO2-RR. The goal is to discover new, efficient catalysts on the basis of fundamental insight. In the first phase, model RuOx and MoSx catalysts (nanoparticles, thin films) will be investigated to elucidate the physicochemical parameters that control their performance. In the second phase, synthetic strategies will be applied to enhance the catalyst activity and selectivity; these will be based on the preparation of metal substituted RuOx and on the exploitation of catalyst-support interactions.The proposed investigation is:• Timely, given the relevance attributed by the European Union and by the chemical industry to the research on CO2 re-utilization strategies that involve the integration of renewable energy sources;• Innovative. RuOx and MoSx are promising, yet largely unexplored catalysts for the CO2-RR. The strategies devised to enhance their performance are radically different from what has been proposed so far.• Expected to provide high impact. The structure-activity descriptors identified through this study will open new perspectives for the design of efficient catalysts via controlled synthetic processes. The research methodology is based on the synthesis of well-defined catalysts coupled with a multi-analytical chara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'KAM Patch, the Smart Sweat Patch:  a breakthrough platform for hydration monitoring' (2014-2020).

assistant: **Innovation**

Dehydration is a silent threat affecting the health and wellbeing of a large fraction of the world’s population. Vulnerable groups such as children, older people, pregnant and breastfeeding women, athletes and outdoor workers present the highest prevalence, resulting in associated acute and long-term health risks. Our property technology (EP17382045) is KAM Patch, a wearable smart patch that monitors hydration through sweat analysis, wirelessly and in real-time. KAM Patch is created with novel nano-inks capable of transforming commodity materials such as paper, rubber or cotton into smart sensing materials. Through the latest generation of flexible electronics, the device can be embedded in mass-market daily objects, such as patches or Band-Aids. KAM Patch is simple, affordable and does not require direct user intervention, which facilitates market adoption. This will help people to make smart choices, thus improving their quality of life and producing a positive impact on public health.   The market for this product is still emerging, which is very interesting from a business point of view. Kamleon’s goal is to take a strategic market position in the development of this new health and well-being business. Furthermore, KAM Patch is very different from the technologies currently present in the market, regarding cost and user experience. It is expected that both Kamleon’s value proposition and business models will evolve through time. Initially focusing on hydration, we forecast initial sales during year 3, with a CAGR of 70% and 90 % the following 4 and 5 years through an intensive commercialization and internationalization plan, with an estimated 12 M revenues, generating an employees’ growth from 4 to 52 professionals during year 5.This Phase 1 will consist of a thorou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unlocking the potential of EU cultivated quinoa through the production of protein-rich quinoa flour and functional quinoa starch' under Horizon 2020.

assistant: **Concept**

The European Union is seeking solutions for reducing its dependency on protein imports, while consumers shift from animal to plant-based proteins. As an example, the global plant protein ingredients market is expected to reach more than €11bn by 2025. Currently 98% of the protein in this market comes from soy and wheat. Soy is mainly imported from non-EU countries (where GMO crops are authorised) and its intensive cultivation causes severe environmental issues e.g. deforestation and land-use changes. On the other hand, wheat protein needs to find a gluten-free replacer. Thus, EU food manufacturers are searching for alternative plant-based sources for their protein-fortified food products, which leads to an urgent need to scale-up the production of plant-based protein from alternative sources. Quinoa is recognised as an excellent crop with an outstanding protein quality and an amino acid score of 100% for adults. Its production in the EU has significantly grown in the last decade. However, commercial exploitation of quinoa-protein and its co-ingredients is not carried out because of the lack of breakthrough fractionation technology adapted to the special nature of quinoa seeds. We are GreenFood50, a Dutch company devoted to the production and commercialisation of quinoa-derived ingredients. We have developed QUINNOVA, an innovative dry fractionation technology that allows to unlock the full potential of quinoa. QUINNOVA food ingredients are in line with consumer demands and their functional properties are ideal for being used in tasty bakery, health, sports, vegetarian/vegan and gluten free applications. The process is environmentally friendly, with a reduced energy and water demand compared to alternative technologies. Our goal is to scale-up QUINNOVA to industrial leve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'REgeneration of inner ear hair cells with GAmma-secretase INhibitors to regain hearing in patients with sensorineural hearing loss' (REGAIN).

assistant: **Innovation**

Hearing loss is a chronic non-communicable disease disabling over 328 million adults, and 32 million children worldwide. Sensorineural hearing loss due to loss of auditory hair cells was long thought to be irreversible. However, recent animal studies have demonstrated that pharmacological inhibition of cell signalling via Notch receptors using gamma-secretase inhibitors (GSIs) can regenerate hair cells and partially restore hearing capacity. This novel therapeutic concept provides the first promising lead for actual treatment of hearing loss. Clinical validation of these findings is the next crucial stepping stone in the development of a regenerative therapy for hearing loss. The ambition of REGAIN is to repurpose a GSI molecule for this indication by shifting from systemic to local treatment.The objective of the REGAIN project is to demonstrate and exploit the efficacy of locally administered GSIs to improve hearing through regeneration of inner ear hair cells with a lasting effect. The project will involve 1) the upscaling of GMP production of the clinical GSI candidate, 2) the generation of preclinical data on GSI dosing and local safety, 3) medical ethical clinical trial approval and 4) the demonstration of proof of concept for GSI for treatment of patients with recent onset sensorineural hearing loss. Small molecule drugs targeting the underlying biological causes of hearing loss in a safe way are expected to meet a real medical need for millions of patients, who currently rely on the limited benefits provided by hearing aids or cochlear implants. The partners involved in REGAIN represent the current state of the art in regenerative hearing loss research in the EU. REGAIN will break through that current state of the art, and will advance the first highly promising
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ocean Artificial Upwelling' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The productivity of the ocean is limited by the transport of nutrient-rich deep waters to the sun-lit surface layer. In large parts of the global ocean this transport is blocked by a temperature-induced density gradient, with warm light waters residing on top of heavier cold waters. These regions, which are referred to by scientists as ocean deserts, are presently expanding due to surface-ocean warming. Enhancing the upward transport of nutrient-rich deep waters through artificial upwelling can break this blockade and make these waters more productive. Forced upwelling of deep-ocean water has been proposed as a means to serve three distinctly different purposes: (1) to fuel marine primary production for ecosystem-based fish farming; (2) to enhance the ocean’s biological carbon pump to sequester CO2 in the deep ocean; (3) to utilize the surface to deep-ocean temperature gradient to generate renewable energy via Ocean Thermal Energy Conversion (OTEC). Whereas theoretical and technical aspects of applying artificial upwelling for these purposes have been studied to some extent, the ecological responses and biogeochemical consequences are poorly understood. Ocean artUp therefore aims to study the feasibility, effectiveness, associated risks and potential side effects of artificial upwelling in increasing ocean productivity, raising fish production, and enhancing oceanic CO2 sequestration. This will be addressed through a combination of experiments at different scales and trophic complexities, field observations of eddy-induced upwelling in oligotrophic waters, and ecosystem-biogeochemical modelling of pelagic systems fertilized by nutrient-rich deep waters. If technically feasible, ecologically acceptable, and economically viable, the use of artificial upwelling for ecosyst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'European network for surveillance of tick borne diseases (TICK-BORNE DISEASES)'.

assistant: **Innovation**

In order to better appreciate the incidence and the possible impact of tick-borne diseases in Europe we propose to set up a Network between references laboratories and medical centres of 5 European countries. The main goal is to construct a database of epidemiological, clinical and laboratory data of patients with a tick borne disease. In parallel will be constructed a tissue bank in order to be able to further investigate the etiological agents of tick-borne diseases. One can imagine that depending on the incidence and medical significance of each of these diseases the network would suggest that one or several of theses diseases would be reportable in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Flexible Genome: understanding the genetic regulation of Phenotypic Plasticity.'.

assistant: **Innovation**

In multicellular animals, complex phenotypic traits such as behaviour, lifespan and diseases are not only determined by genetic factors but also in large part by the environment. Understanding how genes and the environment interact to produce fundamental traits is a major question in biology. Many organisms are capable of expressing multiple phenotypes from a single genome when exposed to different environments. This widespread phenomenon is termed phenotypic plasticity (PP). The genetic programs needed to produce alternative phenotypes are encoded within a single genome, and environmental stimuli determine which form is expressed. PP is highly relevant in nature as it allows organisms to survive and reproduce successfully in variable environments. Nevertheless, the molecular and genetic mechanisms responsible for this flexibility are surprisingly poorly understood. Here, I will investigate the genetic basis of PP by applying advanced genomic and computational techniques to an ecological model of PP, the butterfly Bicyclus anynana. In particular, I will 1) identify the genetic programs that produce alternative phenotypes from a single genome; and 2) assess the potential for evolutionary change in PP by characterising genetic variation in these programs. I will do this by applying RNA-Seq and gene co-expression networks to an ecologically well-characterised insect and developing and integrating methods and concepts across disciplines. Combining my significant expertise on the model system with the host laboratory’s outstanding track record in evolutionary genomics and bioinformatics, this project offers a unique opportunity for obtaining an unprecedented and long-desired insight into the genetic mechanisms of PP. This fellowship will train me in precisely the technical a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of novel multiplexed SPEX-based methodologies to accurately genotype forensic, archaeological, and other marginal environmental sources of DNA' to be submitted under Seventh Framework.

assistant: **Abstract**

Traces of surviving degraded DNA in marginal clinical, forensic, archaeological, and environmental samples are generally amplified by PCR, which can often produce highly-skewed product distributions dominated by non-authentic sequences (due to DNA damage and PCR-generated artefacts). The applicant has developed the SPEX amplification methodology, an alternative to PCR which has generated sequence data of unprecedented accuracy from specimens up to 60,000 years old. SPEX creates first-generation copies from target template strands at defined loci and can generate a quantifiable redundancy of coverage (providing in-built controls for the detection of contamination and allelic drop-out). SPEX has provided key insights and solved long-standing puzzles in the molecular processes of DNA degradation. The applicant would be fully-trained in every aspect of state-of-the-art multiplexed genotyping methodologies, at a host institution currently providing high-throughput data for population genetics, disease association and forensics studies in worldwide collaborations. The proposed project to develop multiplexed-SPEX systems could reduce genotyping errors down towards the background level of polymerase misincorporation, allowing the rapid and reliable quantifiable genotyping of even highly marginal samples. This could revolutionise the authentication of sequence data in areas as diverse as basic cancer research, forensics, biomolecular archaeology, and conservation biology. In addition, highly-promising prototypes for the whole genome amplification of marginal DNA could allow key samples to be 'immortalised' for prolonged in-depth genetic analyses. The proposed project would create new hybrid technologies, useful in many fields throughout the EU and beyond. The enthusiastic backin