RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Changing Glaciers: Enhancing International Research Capacity and Learning Collaboration in Reconstructing the Impacts of Glacier Responses to Climate Change'.

assistant: **Innovation**

Climate change over both geological and human timescales has an immense impact on Earth environments. Changes in mountain glaciers provide both a particularly sensitive indicator of local-to-regional patterns of climate change and are crucial for water resources and natural hazards in mountainous regions and adjacent lowlands.  An international research project, led by Professor Stroeven at Stockholm University, is focused on reconstructing changes in mountain glaciers across Central Asia. As a MCIIF, Professor Jon Harbor, a recognized senior leader in interdisciplinary research and education in glacial studies, will play a central role in this international research project. Professor Harbor will co-lead the fieldwork, be a primary collaborator in analyzing results and writing journal publications with faculty and students in member states and ICPCs, and will co-lead and evaluate collaborative online international educational modules involving students in the member states and the US. His work will enhance and reinforce research excellence in both the lead member state (Sweden), and five other member states and ICPCs (Germany, Kyrgyz Republic, Mongolia, Russia, and China).  Professor Harbor’s unique areas of expertise for the MCIIF include terrestrial cosmogenic nuclide methods for glacial research, and development and evaluation of novel online collaborative learning.  Outcomes of the MCIIF will include a significant broadening of the competences of the host and collaborating organisations, in particular in interdisciplinary expertise and in building long-term, mutually beneficial cooperation between Europe, the USA and Asian ICPCs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'AlzheimersInAction: A multi-disciplinary approach to determine the cellular and molecular mechanisms underlying the inflammatory response to amyloid-β in Alzheimer’s disease.' under Horizon 2020.

assistant: **Concept**

In addition to devastation for the patients and their families, Alzheimer’s disease (AD) generates enormous costs for the wider European economy and is an urgent health priority. There are currently no drug treatments that can cure AD or other common forms of dementia. This absence of therapeutic interventions comes from a lack of understanding about the biological changes that cause most neurological diseases. It is critical to fill in the gaps in our understanding of what biological changes are occurring during the early stages of AD in order to develop treatments that could slow progression or delay the onset of AD. The comorbid nature of this disease and the difficulty of capturing neurobiological processes in action in real time have made it very difficult to determine what changes in the AD brain actually cause the synaptic and neuronal damage that leads to behavioural symptoms. To overcome these difficulties, I propose a multi-disciplinary approach that combines and develops cutting-edge techniques in Drosophila cell biology, molecular biology, time-lapse imaging, computational modelling, and electrophysiology in parallel with exploitation of the powerful molecular genetics, versatile promoter systems and rapid development of flies. Specifically, throughout AlzheimersInAction I will use these techniques to develop an in depth understanding of how an overproduction of amyloid-β causes downstream pathologies, and how activation of the immune cells during AD causes disease pathogenesis. By the completion of this project we will have a greater understanding of the cellular and molecular mechanisms underlying the inflammatory response to Aβ in Alzheimer’s disease. With 10.5 million EU citizens currently living with dementia, and this value predicted to increase at an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Chemical markers for autism: a metabolite profiling study'.

assistant: **Innovation**

Autism is a condition involving abnormal childhood neurological developmental behaviour. Whilst there are accepted diagnostic criteria based on behavioural testing, there is at present no consensus on biochemical factors involved in this chronic condition, and no drug-based treatments prove to ameliorate the condition. Research on autism is of enormous importance for society, yet relatively few papers on the disease are published in journals surveyed by databases covering the physical and biological sciences .The aim of this project is to apply a metabolite profiling approach in an unbiased strategy for finding markers for autism, with the goal of assisting diagnosis and identifying metabolic pathways which have been disturbed.Objectives are to use:(i) LC-MS, capillary electrophoresis and NMR to collect analytical data on urine samples from autistic and non-autistic children,(ii) data analysis to locate significant difference features between the data from control and autistic population sets, and a data-fusion approach to elucidate and combine difference features from the three methodologies,(iii) MS/MS and NMR to obtain structural information and identification of compounds responsible for difference features.The proposed project will allow the researcher to complete her previous research experience in an international setting and will provide the researcher training in a multidisciplinary field of importance for her professional career as an independent scientist. Results on autism from the proposed project will also be valuable for society. This work has the potential to identify the points at which metabolism has been disturbed in the condition of autism, and thus point the way for new diagnostics and targets for treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Cortical interactions underlying the selection of actions' under Sixth Framework.

assistant: **Concept**

Research into the functional architecture of the human brain is increasingly focusing on the interaction between separate modules in the brain. Rather than labelling brain functions to neural structures on a one-to-one basis, it is now recognised that any cognitive function is the result of the combined activity in different regions of the brain.Consequently, the question of how activity in one part of the brain influences another part of the brain (the effective connectivity) is rapidly becoming the central focus of research today. The proposed project will focus on the effective connectivity in the motor system. Using a novel technique for assessing effective connectivity (paired-pulse TMS) test participants will be asked to perform a variety of movements.Successful performance on these tasks is suggested to depend on the interaction between various motor-related regions in the human brain. The project will focus both on healthy participants and patients recovering from stroke, in which communication, and thus the connectivity, within the motor system is suggested to be impaired. The goal of the project is to gain insights into the functional connectivity underlying the selection of actions in the human brain.The project will allow a young and talented researcher with a background in neuroimaging of the brain and motor system to acquaint himself with the study of effective connectivity using paired-pulse TMS. He will work in a laboratory that has a well-established reputation in the development and application of novel methods for the study of cortical interactions.Apart from allowing the researcher to acquire a number of new fundamental and clinically oriented research skills, this project will also allow him to further integrate into the international scientific com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Evaluating the Performance of Fuel Cells in European Energy Supply Grids' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

It has become apparent in the development of the Fuel Cell and Hydrogen Joint Undertaking (FCH JU) Multi Annual Implementation Plan (MAIP) and Annual Implementation Plans (API) that it is difficult to formulate precise targets and requirements for stationary fuel cell applications due to the complicated interaction of FC system operation with grid specifics and the differing goals of FC implementation in the Member States. Neither for efficiency and emission levels, for example, nor for more technical specifications like cycling ability and turn-down ratio can clear targets be set and benchmarks applied that are independent from the energy supply grid  environment the FC system is operating in.Therefore it was decided to omit such targets from the JU programme, which on the other hand constitutes an unsatisfactory situation due to the lack of clear technical guidelines.The project will contribute to solving this situation by collecting and reviewing information on stationary FC operations in various grid environments and application strategies. From this analysis and using information on competing technologies and their future development, benchmarks and targets for stationary fuel cell applications in Europe will be developed and coordinated with the relevant European stakeholders, as well as with the FCH JU and the Commission. These benchmarks will be essential in assessing the progress of the JU programme in improving fuel cell technology and the advantages fuel cells can offer over conventional technologies in the context of different energy supply grids.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Developing cross compliance in the eu - background, lessons and opportunities'.

assistant: **Concept**

Cross compliance is a mechanism for attaching environmental conditions to the receipt of agricultural support payments, which is a means of integrating environmental objectives into agricultural policy. The Agenda 2000 CAP reform enables EU Member States to implement cross compliance under Regulation (EEC) 1259/1999, which has been taken up by some countries. However, the use of this instrument is in its infancy and many questions remain about its most appropriate and effective use to promote sustainable development in a EU context. This project will investigate national responses and discuss key issues in applying cross compliance within the EU. It seeks to develop a better and informed understanding of the advantages, the appropriate mechanisms and the constraints of cross compliance as a means of integrating environmental and agricultural policy objectives within the developing framework of rural policy in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'A prime boost strategy for immunotherapy of breast and ovarian cancer'.

assistant: **Innovation**

This project aims to develop a protocol for effective immunotherapy of breast and ovarian cancer based on a prime boost strategy and the MUC1 antigen which is over-expressed and aberrantly glycosylated in 90% of these malignancies. The strategy will combine cDNA priming with a glycoprotein boost. Different cancer-associated glycoforms of MUC1 will be produced in CHO cells, wild type, and modified by transfection of specific glycosyl transferases. The glycoproteins will be purified, characterised and comparatively evaluated with MUC1 cDNA for efficacy in tumour rejection in mouse models. Chemo-enzymically synthesised MUC1 glycopeptides will be used to evaluate immune responses. Conditions for production to GMP standard of MUC1 cDNA and the selected glycoprotein will be established to prepare for a clinical study. The pattern of glycosylation in cancer cells will be defined with microarray technology and MUC1 cDNA modified.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Regulation of synaptic development and plasticity by molecular pathways linked to human evolution' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The synapse is a nanoscale machine, which transfers, integrates and stores information in brain circuits. Its function relies on multimolecular networks of interactions whose composition and dynamics shape synaptic transmission. A large body of evidence indicates that synapses specialized in humans. Human synapses are more densely distributed along dendrites and their period of maturation is protracted compared to rodent or non-human primate synapses. The rules governing their plasticity also differ from the other mammalian species studied so far. These traits contribute to the formation and function of complex circuits supporting human cognitive abilities. Yet, the underlying molecular mechanisms are not known. Here we will investigate the role of molecular pathways linked to human evolution in the regulation of synaptic development and plasticity. The proposed research takes advantage of my previous work on Slit-Robo Rho GTPAse-activating protein 2 (SRGAP2), one of the few genes specifically duplicated in humans, and the only one implicated at synapses so far. We will use the duplications of SRGAP2 as a thread to uncover i) fundamental mechanisms of synaptic development and plasticity, and ii) regulations specific to human synapses. To achieve our goals, we will employ a multi-disciplinary approach based on in vivo manipulations in intact mouse cortical circuits, mass spectrometry, live-cell single-molecule super-resolution microscopy, electrophysiology, and engineering of cortical neurons derived from human pluripotent stem cells. The combination of mouse and human models will allow us to establish a robust framework to bridge the gap in knowledge between cellular neurobiology and human brain evolution, and better understand synaptic dysfunctions in neurodevelopmenta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International Cooperation in Aviation Research' (ICARe).

assistant: **Concept**

ICARe is a Coordination and Support Action addressing the international cooperation area of the topic MG-1.5-2016-2017: Identification of gaps, barriers and needs in the aviation research.Europe has a leading position in aviation, but needs to maintain and strengthen this position. A new Strategic Research and Innovation Agenda (SRIA) was elaborated by ACARE to address this challenge. The international cooperation contributes to the achievement of SRIA goals but requires a dedicated strategy based on a holistic approach and in depth analysis. ICARe will fulfill this gap and deliver recommendations with regards to International Cooperation for the Aviation Research and Innovation. To do so, ICARe starts with the analysis of past and current cooperation in order to draw lessons. A worldwide mapping of technologies of interest for aviation – even if they originate from other sectors - will be embedded in a secured on-line database. For each of the 21 countries addressed previously by the ACARE INCO group in 2015, a detailed and documented country profile will be established, including technical and non-technical aspects (IPR, trade regulations, cultural barriers and funding organizations, etc.). These results will be enhanced by concrete dialogues and actions through 6 open platforms with the representatives of selected countries (USA, Japan, Canada, China, Russia and the 6th country to be selected during the project). Thanks to this approach, ICARe will support the European Commission in the definition on its International cooperation strategy. ICARe will also facilitate existing and future partnerships in order to fulfill the technological needs identified in the SRIA.The consortium includes 12 partners representing industries, operators, research centers, universities,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Dissecting renal metabolic reprogramming heterogeneity to target kidney fibrosis' to be submitted under Horizon Europe.

assistant: **Abstract**

Chronic kidney disease (CKD) affects 10% of the population and fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of CKD. Myofibroblasts are the key ECM producing cells and are activated by cross-talk with injured proximal tubule anChronic kidney disease (CKD) affects 10% of the population and fibrosis driven by excessive accumulation of extracellular matrix (ECM) is the hallmark of CKD. Myofibroblasts are the key ECM producing cells and are activated by cross-talk with injured proximal tubule and immune cells. Although a derangement in fatty acid oxidation (FAO) of tubular epithelium is crucial in the pathophysiology of CKD, the metabolic rewiring of kidney myofibroblasts remains elusive. Our preliminary observations suggest that cell type-specific metabolic shifts could define new cellular subpopulations with a differential role in the fibrogenic response. To understand this, the following objectives have been defined: 1. To decipher the role of FAO in myofibroblasts during kidney fibrosis; 2.To dissect metabolic changes as important drivers of kidney fibrosis and CKD; 3. To validate key metabolic pathways in complex ex vivo models of kidney fibrosis. To address these aims, I will map the genetic and metabolic spatio-temporal features of kidney fibrosis by a combination of cutting-edge multi-omics technologies at large scale (Spatial single cell ATAC sequencing for transcriptomics and Space M for metabolomics). This will be complemented by advanced computational analyses and modeling, using CKD human biopsies and mouse renal samples from available genetic models for myofibroblast tracing and FAO enhancement. Innovative in vitro systems (cell coculture and kidney organoid systems) will be used to identify and target cell type-specif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Digital Adaptive Filter Design Based on the Fast Affine Projection Algorithm and the Logarithmic Number System Arithmetic' (LFAPDIFI) under Sixth Framework.

assistant: **Objectives**

The aim of the project is to study the design of a digital adaptive filter at algorithmic level and its efficient implementation in an FPGA device. The use of the Fast Affined Projection (FAP) adaptive algorithm proposed in this project represents a qualitative leap in digital filter design. A class of the FAP algorithms outperforms the classical Least Mean Square (LMS) approach used in commercial devices for digital filtering with many parameters and fast adaptation, without substantial increase of complexity. The thorough investigation and analysis of the FAP will provide a sound theoretical background in order to design an efficient FPGA hardware implementation. A successful implementation of the fast and robust digital adaptive filter requires the use of inappropriate floating-point like arithmetic suitable furan FPGA device. The application of the Logarithmic Number System (LNS) arithmetic as an alternative to the standard floating-point appears to be an attractive and suitable solution. The project will build on an existing cooperation between two partners, one from an EU member country and one from an Associate Candidate Country. The project will provide the young researcher from the prospective country with the opportunity to work within the advanced research group preparing him for work in unified Europe. Thus, the collaboration in this project will provide a step forward towards the integration of the prospective members to the European Community.