RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A patient specific approach to tissue expansion in breast reconstruction' to be submitted under Horizon Europe.

assistant: **Abstract**

Breast cancer is the most prevalent cancer globally, affecting 13% of women in their lifetime. For those women who undergo a mastectomy, breast reconstruction has become an integral part of their treatment. While two stage implant-based reconstructions are by far the most common procedure, they are sub-optimal: They suffer from high complication rates and low patient satisfaction. The first stage of implant based reconstructions involves the insertion of a tissue expander, silicone implants gradually inflated below the skin over several weeks to induce new skin growth. Improving patient outcomes and patient satisfaction requires a deep understanding of the biomechanical mechanisms associated with growing new tissue and the challenges associated with predicting its future behaviour. However, the lack of adequate in vivo techniques to evaluate and predict the amount of tissue growth is an obstacle to effective surgical planning.BreastRecon aims to address these challenges by developing a novel acoustoelastic method which can non-invasively determine key biomechanical parameters. Specific objectives of BreastRecon include (i) the development of a wearable surface wave device for clinical in vivo measurements (ii) the quantification of in vivo tension using the device (iii) the non-invasive determination of tissue growth and (iv) the development of a real-time optimisation procedure for the design of tissue expansion protocols. To achieve these ambitious goals, BreastRecon employs a distinctive combination of acoustoelastic tissue measurements, physics-based machine learning techniques and novel device development.BreastRecon will initially provide a tool to monitor tissue growth in vivo, offering valuable fundamental insights into growth and remodelling processes. Ultimate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Systems Biology to understand Plant Architecture', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Extensive feedback between gene expression state and the cellular environment yields  tangled hierarchies . This lack of strictly hierarchical control mechanisms poses a challenge to developmental biologists: the outcome of interaction networks with extensive feedbacks is not intuitive and must be analyzed with analytical tools. Here, I propose a combination of experimental and theoretical approaches to study control mechanisms of plant architecture and their emergent properties. The plant hormone auxin appears to be a major player in developmental patterning and architecture. We and others have shown previously that auxin distribution patterns can self-organize and elaborate different architectures by principles of self-organization. We have discovered that the PLETHORA transcription factors, which form instructive gradients during root development, are involved in early embryo and shoot development as well, and that they constitute a  principal component  of plant development. Excitingly, PLETHORA genes are regulated by auxin accumulation but they feed back on the most important actors that determine auxin distribution, the PIN proteins. The dynamics of this PLETHORA-PIN loop can display emergent properties that may explain the majority of principal patterning events that determine root and shoot specification as well as branching. Here, I propose to investigate this feedback system in detail using (1) molecular genetic approaches, (2) computer modelling and (3) functional genomics approaches. The projected outcomes are a deep understanding of major control mechanisms for tissue pattern and organismal architecture and general insights into genetic information encoding using tangled hierarchies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Handy natural ventilation rate calculator based on computational fluid dynamics' in the context of a Seventh Framework call.

assistant: **Objectives**

Considering crop and animal production, IAQ, gas emissions, associated health effects and socio-economic problems, one of the biggest issues, these days, in Europe as well as in the world is to measure the ventilation rate of naturally ventilated buildings. Among various direct and indirect methods, the CFD approach can produce the most practical and timely solutions because of its outstanding potential for analyzing complex air flows. In this project, the candidate will develop a free simulation tool to predict the ventilation rate of naturally ventilated agricultural buildings, such as greenhouses and livestock houses. As next generation of CFD approaches, the free simulation tool, HNVR calculator, will be built of automated user interfaces and the CFD technique so that users can directly use the program without CFD experts in simulating the air flows in and around the buildings with convenience and stable accuracy of the results. Regarding the ventilation researches, the host institute, M3-BIORES in KU LEUVEN, has accumulated knowledge and experiences over the decades, whereas the applicant has been working on simulation research and its applications. Therefore the applicant will provide new perspectives on solving problems by bring the state-of-art knowledge and experience to the host institute. In addition, active knowledge transfer between them will create a synergetic effect on completing this project and enhance the European host Institute’s position at the forefront of advances in this field. This project will also encourage long term collaborations between the European host group and the Korean research group (Aero-Environmental and Energy Engineering Lab.) which is one of the biggest leading group in the field of agricultural engineering in Korea.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Optimal use of hospital resources and intervention using suPAR for improving prognosis and care for patients with COVID-19' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Optimal use of hospital resources and intervention using suPAR for improving prognosis and care for patients with COVID-19 To optimize hospital resources, it is necessary to test which patients that can be sent home (mild outcome of infection) and which patients that should be admitted to hospital (high risk patients). This will deliver on the tasks: 1) Identify patients that can safely cope with the infection at home and 2) Identify high risk patients early in the disease and 3) Select high-risk patients that may benefit of therapy.But how can we identify low- or high-risk patients?The suPARnostic test developed by ViroGates and CE/IVD approved for clinical use is highly prognostic marker for 30-day mortality. Some hospitals have suPAR in routine clinical assessment of patient risk, and preliminary data support that suPAR levels can triage whether patients with COVID-19 will have a mild or a severe outcome of COVID-19 and thereby select which patients that could be discharged or admitted.We aim to transfer manufacturing, upscale and implement the suPARnostic technology across hospitals in Europe to improve the risk stratification of COVID-19 patients and optimize hospital resources. We furthermore provide a test method that can identify high-risk patients that may benefit from experimental therapeutic interventions that may impact on outcome. The identification of patients in high risk of mortality (patients with high suPAR) provide a possibility to intervene.


**Keywords:** Risk status biomarker suPAR, risk prediction, COVID-19, antiinflammatory treatment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanocrystalline heterosupermolecular materials for optoelectronic applications' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Europe has world leading expertise in the fields of both supermolecular photochemistry and optoelectronic applications of nanocrystalline metal oxide films. This programme brings together expertise from both of these fields to adress the development of inn ovative heterosupermolecular devices which combine the specificity and unique functionality of supermolecular chemistry with the nanometer scale strcutural control and ease of integration into electronic devices of nanocrystalline metal oxide electrodes. T he project will be science focused, with specific technological objectives. Key scientific elements of the project will be the synthesis of supermolecular structures designed both to achieve the desired functionality and including binding groups for ligati on to metal oxide surfaces, the self-assembly of these structures on the surface of mesoporous, nanocrystalline films, the electrochemical and photochemical evaluation of the resulting heterosupermolecular systems, and the functional evaluation of these sy stems for technological applications. The project will target the demonstration of four innovative heterosupermolecular devices: ligth emitting diodes, optical data storage devices, magneto-optical data storage devices and electro-optical sensing and switc hes. The proposal will be at the meeting point between supermolecular chemistry, nanostructured inorganic materials science and optoelectronic device physics. It is therefore highly multidisciplinary and involves leading European groups working in organic, inorganic, biology, physical and materials science. This project will develop a critical mass of expertise targeting this innovative approach to optoelectronic devices, allowing Europe to establish a scientific world lead which will form a secure basis fo r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Family structure, labour market participation and the dynamics of social exclusion'.

assistant: **Objectives**

The project has six objectives: (i) to increase the understanding of the processes of social exclusion and social reintegration in Europe by using an explicitly dynamic approach; (ii) to examine and compare the extent and impact of social exclusion among men and women at transitional stages in the life course; (iii) to establish the ways in which the policies of Member States affect the risk of social exclusion during these transitions; (iv) to explore the effect of community and family structures on the extent and experience of social exclusion associated with life course transitions; (v) to assess the contribution that the European Community Household Panel (ECHP) can make to the analysis of social exclusion, and make recommendations for improvements to the survey; (vi) to improve the dissemination of techniques for analysing social exclusion throughout Europe. The use of an explicitly dynamic approach to the analysis of social exclusion is fundamental to the proposed project. It will make extensive use of the ECHP to apply dynamic analysis on a comparable basis to the six countries in the study: Austria, Germany, Greece, Norway, Portugal and the UK. However, it will also make use of national datasets to complement the ECHP analysis, and will use in depth interviews to provide a deeper understanding of the social processes at work. The combination of dynamic and comparative analysis can be expected to generate new knowledge and theory, thus helping in the formulation of more effective policies at the level of national governments and the European Union.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Surface Plasmon early Detection and Treatment Follow -up of Circulating Heat Shock Proteins and Tumor Cells' to be submitted under Seventh Framework.

assistant: **Abstract**

Cancer causes an increased expression of Heat Shock Protein HSP70 in the peripheral blood, at the surface of, and in cancer cells as a result of different sources of stress, including anti-cancer treatments. It was recently demonstrated that tumorigenicity, metastatic potential and resistance to chemotherapy correlated with an increased of expressed HSP70 in cancer cells. On the contrary, HSP70 depletion using combinatorial small peptides called peptide aptamers sensitizes cancer cells to die and could help in cancer therapy.The core goal of this project is to combine the latest advances of nano-optics, optical manipulation and microfluidics with the ultimate understanding of HSP70 to develop a novel integrated and ultra sensitive sensing platform for early cancer detection. An early detection would benefit to traditional but also new cancer therapies based on peptide aptamers which could be delivered sooner and at lower doses. The planned sensing device, based on surface plasmon resonances supported by micro and nano-structures, will operate in a microfluidic circuit to minimize the volumes of analytes and increase reproducibility. Enhanced and confined plasmonic fields will be engineered at the nanoscale to implement two main sensing schemes: (i) ultra sensitive tracking of HSP70 proteins circulating in the peripheral blood based on resonance shift induced by specific protein/receptor binding, (ii) individual cell optical trapping (exploiting latest generation of plasmonics tweezers) combined with scattering imaging and Surface Enhanced Raman Scattering to monitor the concentration of HSP70 proteins at the membrane surface and achieve systematic cancer cell screening. These transduction mechanisms and plasmonic tweezers will be integrated into a compact platform to op
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Charm, a laboratory for QCD' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Accurate measurements of specific charm particle decays are needed to provide calibration for lattice-QCD calculations. These inputs are crucial to extract electro weak parameters as the CP violation phase and light (u, d, s) quark masses. These are among the objectives of the CLEO-c experiment, which starts taking data by mid-2003. Several of these measurements can be conducted at b-factories using the large, already registered, statistics of charm quark pairs produced in the continuum. The applicant will be a member of a group of French and German physicists who are already involved in the Barbary collaboration. She will contribute to general-purpose activities in the collaboration and in the development of tagging tools to select D°, D+, Ds and charm-baryon samples. Physics analyses will be centred on the study of semileptonic decays of these particles and on lepton decays of the D+ and Ds mesons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated knowledge on functional genomics in sustainable aquaculture' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

A number of projects, using molecular technologies and a functional genomics approach to improve sustainability of European aquaculture, have been funded within the EU 5th and 6th frame work program. An integration of the outcome of these projects would undoubtedly contribute to build a large common knowledge base in this area. A synthesis of the different data sets can be expected to give a potentiated effect, creating a more significant output than the sum of the individual projects. Integration and communication of the different projects outcome would also reduce possible overlap both currently and in the future. Bringing together a large number of research groups/projects in a common forum should generate a critical mass and improve European and International visibility in this important area of production. The overall aim of the present project is to integrate the outcome of the projects within Framework Program 5 and 6 that concern genome mapping and functional genomics in aquaculture, in order to generate a common scientific basis of a functional genomics approach to aquaculture. This will be achieved through a series of instruments including work group meetings, analyse and combining of results in joint scientific publications as well as the creation of a common internet site containing both public and restricted, accessible for registered scientific members, areas.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Asymptotic methods in the spectral analysis of ordinary differential operators' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content The purpose of this project is to extend and develop the use of asymptotic methods in the spectral analysis of singular differential operators of Sturm-Liouville type. These operators have widespread applications in Engineering and the Physical Sciences, and include the one-dimensional Schrodinger operator. The proposed work will focus primarily on exponential asymptotics and the method of subordinacy, although it is expected that other techniques such as asymptotic integration will also be involved. Historically, the various asymptotic methods have developed largely independently, and in differing contexts. Thus the development of asymtotic expansions has been significantly influenced by its applications in fluid dynamics, whereas applications of asymptotic integration and the method of subordinacy are more usually found in quantum mechanics. However, recent work has shown that asymptotic expansions have an important, but as yet underdeveloped role to play in spectral theory, and that significant results can be achieved by combining methods from the different traditions. The main objectives of this project are: (I) To identify, explore and develop relevant links between the various asymptotic methods, with a view to providing a more integrated approach to their use in spectral analysis and initiating new areas of application. (II)To investigate and develop the role of asymptotic expansions in spectral theory, particularly in connection with the phenomenon of resonance poles and in conjunction with the method of subordinacy. (III)To promote the use of asymptotic methods which enable the singular, absolutely continuous, simple and degenerate parts of the spectrum to be distinguished. Training content (objective, benefit and expected impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Understanding the Interaction of T cells and Immune Complexes in Systemic Lupus Erythematosus'.

assistant: **Innovation**

Systemic Lupus erythematosus (SLE) is an autoimmune disease with a complex pathogenesis. Immune complexes (ICs) are formed and deposited in various tissues, leading to inflammation and damage. T cells are part of the adaptive immune system, but also express innate-like receptors that could interact with ICs by binding complement factors or the constant region of immunoglobulins. However, the extent of these interactions and there relevance for the SLE pathogenesis has not been investigated so far. In the TICI-SLE project, we will analyze these interactions by 1) investigating the expression of receptors that could interact with ICs on T cells in the blood and inflamed tissue of SLE patients, 2) cultivating T cells with immune complexes and antibodies stimulating or blocking individual receptors, thereby elucidating the consequences of these interactions and 3) analyzing spatial T cell/IC interactions and their secondary consequences (like proinflammatory changes in stromal cells and chemoattraction of inflammatory cells) in skin samples from SLE patients. We hypothesize that T cell/IC interactions result in (co-)stimulation of T cells, leading to production of proinflammatory cytokines, cytotoxicity and induction of an inflammatory microenviornment. Understanding these interactions can then be exploited by the future development of therapeutics targeting these interactions. An additional focus of the project will be the personal development of the applicant and the dissemination and exploitation of project results.


**Keywords:** Systemic Lupus erythematosus, autoimmunity, T lymphocytes, immune complexes, complement system