RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interoperable applications suite to enhance European identity and document Security and fraud detection' (EINSTEIN).

assistant: **Innovation**

Combatting frauds on identity and travel documents is a key mission of law enforcement agencies and border guards. Industries have been working on new means to combat frauds on identity, and public authorities are using numerous technologies to accomplish their mission, but permanent innovation is required to fight highly skilled defrauders. A number of European innovation projects have tested new ways to combat fraud but few of them reached an operational level.EINSTEIN objectives is to enhance significantly existing public authorities’ means through innovation, building on technologies proven in the labs but not mature for an operational usage yet. EINSTEIN will deliver six applications essential to fight identity frauds: 1) online ID issuance using a secure cloud-based server for real-time biometric quality checks and fraud detection, 2) mobile document and identity checks using commercially available smartphones, 3) document authentication module to detect fraudulent documents, 4) pre-registration for land-border crossings including biometrics and DTC, 5) EES kiosk with advanced fraud detection using video surveillance, 6) fast track for enrolled travelers using on-the-move face and iris. To ensure TRL7 at a minimum, practitioners will run six different pilot use cases in their own environment. A key objective is also to ensure interoperability and flexibility of all the components developed in the project so that they can be reused in different contexts, possibly by different providers. Design of open, well-defined, standardized interfaces will allow achieving this objective.Privacy being an essential concern of all European citizens and governments, EINSTEIN will take into account privacy-by-design principles, developing flexible components to ease their customiza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bioinformatics and Information Retrieval Data Structures Analysis and Design'.

assistant: **Innovation**

Nowadays computers are used to process huge amounts of information, for example a major search engine processes tens of thousands of searches per second. Still the future of the information age is at risk. Computer architectures will not be resilient enough for the next information challenges. It is not only a matter of word size or clock cycles. New DNA sequencing technologies are evolving much faster than Moore's law, this means that they are evolving faster than the amount of transistors that go into CPUs and GPUs. Moreover computer disks are, by far, the slowest part of the architecture and are evolving even slower, therefore widening the relative time that information takes to reach the processor.Processing the amount of information, that will make personalized medicine a reality, requires a new approach. A new class of data structures has recently been developed to address the new challenges in storing, processing, indexing, searching and navigating biological data. Similar tasks have been also tackled by researchers in the information retrieval community: such as designing algorithms for sequence analysis, networks representation or compressing and indexing repetitive data. Synergies of researchers from both fields can lead to new efficient approaches to improve the technology used for analysis of genome-scale data.The overall goal of BIRDS is to establish a long term international network involving leading researchers in bioinformatics and information retrieval from four different continents, to strengthen the partnership through the exchange of knowledge and expertise, and to develop integrated approaches to improve current approaches in both fields. It will be implemented through staff exchanges, in addition to summer schools, workshops and conferences to faci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Elucidating the mechanism of action of cyclotides: ultra-stable proteins from plants' (2007-2013) under Seventh Framework.

assistant: **Objectives**

The utility of conventional peptides in pharmaceutical and biotechnological applications is limited by their poor stability and bioavailability. Cyclotides are plant derived mini-proteins with unique structural properties that make them exceptionally stable and have a range of exciting applications in drug design and agriculture. Beside the variety of intrinsic activities, there are still many unanswered questions regarding the mechanism involved in cyclotides activity. Understanding how they exert their biological effects is a crucial step and is the basis of this proposal. Recent evidence has emerged that these actions are mediated by membrane interactions and this study will determine the chemical and biophysical basis for these interactions. The main goal of this project is to explore the interaction of a selected set of cyclotides with biological membranes. The specific objectives are to evaluate: 1) the structural features important for the membrane binding of cyclotides; 2) the structural basis of membrane selectivity; 3) if the self-association properties of cyclotides are involved in their mechanism of action; 4) the biophysical basis for the effects of cyclotides on living cells; 5) the information from objective 1-4, together with bioactivity data to rationalise the bioactivity of cyclotides. Understanding how cyclotides exert their biological activities will provide valuable information that can be applied in subsequent drug design studies. The outgoing host lab has a strong background on cylotides and several facilities that can be optimized for peptide-lipid studies (NMR and fluorescence spectroscopies, isothermal titration calorimetry and surface Plasmon resonance). An advanced training to complement applicant specific expertise and skills in peptide-lipi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Second generation of planted hardwood forests in the EU' in the context of a Horizon 2020 call.

assistant: **Objectives**

The past EU funding programs for the afforestation of agricultural marginal areas promoted many walnut quality hardwood planted forests in southern Europe, which are mostly small to medium-sized and dispersed in the territory. Although southern European countries have intensively invested in research on walnut silviculture and genetics, the owners of small planted forests lack the know-how needed to properly manage their plantations, being a majority of them poorly managed or abandoned. Moreover, the average age of the walnut plantations and their need for thinnings imply that large quantities of small-diameter trees will be produced in the years to come. However, small-dimensioned European walnut logs are not demanded by wood industry because of the higher transformation costs and because of the competition of the American walnut.WOODNat, focused on the whole walnut hardwood-chain, aims at increasing the use of quality walnut hardwood produced under sustainable management practices in planted forests of southern Europe, which implies adding value to the whole chain of the walnut hardwood market, involving the different stakeholders of the market. To help this approach, WOODNat will benefit from biotechnology, robotics, and the development of a mobile app. Thanks to WOODNat, walnut plant nurseries will improve characteristics of walnut plants in order to reach a higher standard in the market while increasing nursery productivity, and will keep after-sale contact with plantation managers to get feedback of the success of the walnut plants. A whole package of environmentally sustainable management practices, including sustainable innovative approaches to degrade by-products, will be implemented in walnut planted forests, not only in new plantations but also in many now ab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'High-resolution Boron and beyond Geologic reconstructions for carbon and climate processes' in the context of a Horizon Europe call.

assistant: **Objectives**

The link between climate and CO2 is not always straightforward, particularly during periods of multiple climatic and environmental changes, but atmospheric carbon dioxide (CO2) plays an important part in determining climate on human and geological timescales. For example, state dependency of climate sensitivity, the response of Earth’s temperature to CO2, is a critical unknown for future climate projections and policy strategies. Another unknown is the response of the Antarctic Ice Sheet (AIS) at different CO2 thresholds for its melting and growth, “hysteresis”, despite the fact that this will ultimate determine the magnitude of future sea level rise. Existing records suggest that the ice sheet margin waxed and waned since the Eocene, ~50 million years ago (Ma), while CO2 varied within the likely range projected for year 2100 and Earth’s temperature progressively cooled. HighBorG aims to resolve climate-AIS-CO2 unknowns on three periods of the geologic past: 52-46 Ma (hot Earth, high CO2, likely ice free), largely unexplored 39-23 Ma (when AIS was established), and 17-13 Ma (cold Earth, low CO2, dynamic AIS). HighBorG focuses on reconstructing CO2-climate feedbacks at millennial/orbital timescales, a medium risk high gain opportunity necessary to resolve warming and cooling periods at different climate states. To achieve this, a new automated system for purification-analysis will be developed, accompanied by a laser ablation split-stream approach, utilising new marine archives and cutting-edge methodologies. Seasonal reconstructions from contemporaneous tropical corals will provide a novel way to constrain seawater composition, necessary to obtain accurate estimates of CO2. Earth system modelling incorporating reconstructions will provide a new understanding of the mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Large-N Yang-Mills Theory'.

assistant: **Objectives**

Yang-Mills theory describes the strong interactions of quarks and gluons to form particles such as the proton. It is widely acknowledged as an important outstanding problem at the frontier of physics with connections to condensed matter, mathematical & computational physics. The large N expansion is a promising method to solve the strongly coupled infrared of the theory and quantitatively test its predictions. The proposal's 1st part concerns bound states in an asymptotically free theory, Spherical QCD. It is relevant to experimentally measured form factors and spectra of b-mesons. The aim is to find the meson spectrum and wave functions by a non-perturbative renormalization of the bound state equation for color-singlet variables in the large-N limit. The 2nd part concerns dynamical matrix-valued gluons in 2d QCD coupled to adjoint scalars (relevant to gluon distribution of proton) and QCD on a cylinder. We transform to open and closed string variables and determine a variational principle for the large N Schwinger-Dyson equations and approximation methods for them. The applicant did his PhD in USA and received the American Physical Society's prestigious Apker Award. From previous research, he has a good physical intuition and special technical skills necessary for this project. It will be done at Utrecht in The Netherlands, supervised by Nobel Laureate G. 't Hooft. The training (including EU RTN networks) and collaboration with European physicists will significantly advance his research career. His original viewpoint, novel techniques and training in USA will contribute to the excellence and competitiveness of European science. On the long term, the applicant will use the expertise and training to pursue an academic research career in India while maintaining collaborat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Application-oriented studies on regulatory networks involved in lipid homeostasis and atherosclerosis' (SOUTH).

assistant: **Concept**

Cholesterol and lipid homeostasis is achieved through the action of a complex regulatory network (regulome) that controls the expression of genes involved in these metabolic pathways.Our recent studies suggest that:i) high in the hierarchy of the regulatory network is the nuclear receptor HNF4, whose activity on cholesterol metabolism genes is selectively affected by HDAC7 recruitment, and thatii) targeting HDAC7 lowers serum cholesterol levels.Given this premise, the general objective of this proposal is to bridge these new basic science concepts to clinical applications by analysing the transcriptome and the regulome controlling cholesterol and lipid homeostasis and by pharmacologically targeting the HNF4/HDAC7 regulatory axis.We will develop improved strategies for the prevention and treatment of atherosclerosis by pursuing the following specific aims:1. Rational design of high affinity ligands for HNF4 and inhibitors of HDAC7 based on the analysis of their 3D-structures2. Analysis of the global pattern of gene expression (Transcriptome) and transcription factor network (Regulome) involved in lipid homeostasis in control mice and in mice treated with HDAC inhibitors and HNF4 ligands and definition of their pharmacological profile3. Development of clinical diagnostic toolsThe multidisciplinary nature of the proposal will exploit and integrate the expertise in molecular/cell biology, pharmacology, toxicology, medicine, physics/crystallography, chemistry, biochemistry and bioinformatics to identify new molecules affecting lipid metabolism and study their effects on pathophysiological events underlying atherosclerosis.Upon completion of the project we expect to:a. identify HNF4 ligands and HDAC7 selective inhibitors affecting lipid metabolismb. define the effects of thes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'String theory' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

Recently a new class of three dimensional N=8 and N=6 superconformal theory has been discovered. These theories are defined by a classical action and have a (discrete) parameter k that can serve as a coupling constant. Taking k large (coupling small) one can use perturbation Feynman diagram techniques. The theory for k=1 is particularly interesting as it is conjectured to be the N=8 theory living on coincident M2 branes (membranes). Membranes are extended objects in M-theory, and some believe these could be the defining objects of M-theory, much like strings are defining objects of perturbative string theory. This connection between strings and membranes could be interesting to study more and could shed light on M-theory itself. In the nearest future my research will focus on these newly discovered superconformal theories from various viewpoints.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Total Operation management for Safety Critical Activities' to be submitted under Seventh Framework.

assistant: **Abstract**

Over the recent past the accumulation of major mishaps, crises and accidents have made it clear that organisations must still improve their capabilities to address safety “not a stand-alone activity that is separate from the main activities and processes of the organization” but as an integrated part of critical project management. Further it is critical also to understand how weaknesses not only in the technical but also in the organisational interfaces can contribute to significant losses and major industrial accidents.TOSCA (Total Operation Management for Safety Critical Activities) is concerned with the integration of industrial operations into a total performance management system so that concerns about safety, quality and productivity are addressed in an integrated way during life-cycle of a project or a product. The industrial domain of application regards process control industries (e.g., chemical industries, power generation, offshore oil & gas platforms, etc.) that may vary in size, regulatory and cultural aspects. TOSCA will examine vulnerabilities of the technical, human and organisational systems that may have an impact in safety, quality and productivity.  Safety critical activities can be seen as ‘projects’ or ‘safety cases’ that must be examined from the perspectives of many stakeholders (e.g., different departments, subcontractors, regulatory authorities, etc) and decision-making at different organizational levels (e.g., top managers, supervisors and operators).   A participative approach is required that should collect knowledge from the sharp-end operators and integrate it with formal descriptions of how the system works and how responses should be coordinated across the whole organisation. Furthermore, TOSCA should enhance the management of changes a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'eDREAM - enabling new Demand REsponse Advanced, Market oriented and Secure technologies, solutions and business models' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Smart automated Demand Response (DR) represents a valid alternative to grid reinforement for electricity Distribution System Operators (DSOs) to procure in a cost-effective way the necessary flexibility for integrating larger shares of intermittent RESs, while not compromising security of supply and network reliability. However DR potential has been exploited so far to a very limited extent due to a number of technological, regulatory, economic barriers. To cope with these challenges, eDREAM will develop and make available a novel near real time DR scalable secure blockchain-driven technological and business framework aimed to optimize aggregated system services flexibility provisioning to DSOs. The project will research and develop tools and services for: i) optimal DR system design, which includes early detection of flexibility potential via multimodal fusion of aerial, LIDAR and thermal imaging, end users profiling and segmentation by leveraging on big data clustering and large data sets visual interactive exploration and DR optimization services for energy end users; ii) optimal DSO-driven Demand Response management, including novel applications of blockchain decentralized ledger for secure data handling, market-based microgrid control and near real time closed loop DR verification aimed to improve system observability and enable fair DR financial settlement. Novel flexibility market and services/products design, as well as cooperative DSO-aggregator business models enabled by incentive sharing will validate the eDREAM DR technical concept from the economic perspective. The eDREAM technologies will be extensively validated in a lab-based pilot (Greece), followed by two field pilots, a C&I VPP-based optimal aggregated flexibility management in UK and a mixed stationa