RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Diagnostic Test For The Differential Diagnosis of Bipolar Disorder and Major Depressive Disorder' (DDBSD).

assistant: **Innovation**

Neuropsychiatric disorders contribute 13% to the global burden of disease and cost the European economy an estimated 789bn EUR a year. PsyOmics is a Cambridge-based biotechnology start-up focused on reducing this burden by providing scientifically-validated solutions that improve the prevention, diagnosis and treatment of psychiatric disorders. This project relates to the first clinical diagnostic that we intend to bring to market, a test to improve the diagnosis of bipolar disorder and major depressive disorder.It is estimated that 33.4m people within the WHO European region suffer from major depression each year, and around 7m suffer from bipolar disorder. The separation of these two groups for appropriate treatment is very challenging because patients with an underlying bipolar disorder typically present with depressive symptoms that are indistinguishable from those of MDD.  The result is that around 40% of all patients with an underlying bipolar disorder are initially misdiagnosed with depression and prescribed antidepressants, rather than mood stabiliser treatments. On average it takes over 7.5 years for the correct diagnosis to be reached.There is no evidence to suggest that antidepressant monotherapies are effective in treating bipolar disorder and furthermore they are known to lead to an increased risk of anti-depressant induced mania, rapid cycling and suicide attempts among these patients, all of which lead to an increased rate of hospitalisation and healthcare costs. Our clinical diagnostic will reduce this level of misdiagnosis by enabling GPs and Psychiatrists to efficiently identify those that have an underlying bipolar disorder amongst those that present with depressive symptoms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Programmable Reconfigurable Optical Transport for Efficiently offering Unconstrained Services in 6G' (PROTEUS-6G) targeting Horizon Europe.

assistant: **Abstract**

PROTEUS-6G focuses on the development of advanced packet-optical x-haul networking infrastructure, relying on novel software-programmable photonic-integrated-circuit based subsystems operated under an intelligent software management system, capable of simplifying and optimizing network operations and supporting future ultra-high capacity, low-latency and energy-efficient 6G cellular and cell-free MIMO radio access networks.The targeted innovations will enable efficient utilisation of packet and optical resources (spectral subcarriers and spatial lanes), realizing the vision of flexible functional splits (FFSs), adapting the fronthaul, under dynamically customizable operational conditions, to the network demands, for varying distribution of users, traffic demands and use-cases.To implement the 6G optical-enabled radio-access network, the consortium will develop ultra-low energy (low-pJ/bit), ultra-high capacity (0.8 Tb/s) and fast-reconfigurable (sub-ms) software-programmable solutions (i.e. transceivers, multiplexers and fast optical switches integrating tuneable lasers/filters) based on novel photonic processing/switching schemes, to be reconfigured by an intelligent control plane optimizing the utilization of resources across the front-/mid-/back-haul continuum and reducing unnecessary opto-electronic transitions, thus collectively improving performance while minimizing the environmental impact.The PROTEUS-6G consortium covers the entire value-chain of industry/academia organizations focusing on implementing wireless-optical connectivity solutions. The participating experts possess demonstrated expertise re delivering on their promises as indicated by their research track record and exploitation activities towards commercialization of new products and contributions to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PEPtide-based Therapy for recurrent Ovarian Cancer' (PEPTOC).

assistant: **Concept**

Ovarian cancer recurrence after complete clinical response is a major challenge in gynecologic oncology. Recurrence occurs in nearly 25% of early-stage cases and in more than 80% of advanced-stage cases. Current targeted therapies for the treatment of ovarian cancer relapse are still in Phase II clinical trials and, while these therapies represent significant advances in cancer treatment, they target broad inhibitory mechanisms that affect DNA repair and signaling pathways in a variety of cell types, which lead to significant side-effects.To address the critical challenge of recurrent ovarian cancer, PEPTOC’s solution shifts the paradigm from treating recurrence to preventing it. By strategically targeting the cellular pathways involved in chemotherapy resistance, PEPTOC offers a preventive approach to avoid ovarian cancer recurrence.This ERC Proof of Concept project aims to:1) Perform preclinical validation of PEPTOC in an in vivo model. 2) Secure intellectual property and define the commercialization pathway. 3) Develop and implement a comprehensive business strategy. Taken together, the objectives of PEPTOC will pursue the steps necessary to develop a viable therapeutic option: ensure that the therapy is both safe and effective in vivo, protect intellectual property and define the commercialization pathway (spinout company and strategic partnerships, if needed), and engage with relevant stakeholders through a series of activities, including workshops with oncologists, focus groups with patients, and meetings with pharmaceutical representatives and investors at industry events. To guide these efforts, we will rely on the expertise of Key Opinion Leaders serving on an Advisory Board to ensure that PEPTOC’s development is strategically aligned with market needs. If succ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'INFRAFRICA – A comparative study of foreign-financed and foreign-built infrastructure in Africa: perspective from Ethiopia and Angola' (INFRAFRICA) under Horizon Europe.

assistant: **Objectives**

China’s increasing presence in Africa through the Belt and Road Initiative has raised concerns about the development, governance, and foreign policy implications of Chinese-financed, Chinese-built infrastructure projects. At a time in which the European Union is putting African infrastructure investments at the centre of its Global Gateway initiative, my INFRAFRICA project— a comparative study of foreign-financed and foreign-built infrastructure in Africa: perspective from Ethiopia and Angola—expands current knowledge about foreign engagement in the African infrastructure sector. By taking the infrastructure sectors of Ethiopia and Angola as case studies, INFRAFRICA aims to contribute to three interconnected debates. First, the project evaluates the impact of foreign construction firms’ operations on the host countries’ economies. To do so, INFRAFRICA explores and compares the behaviours of Chinese firms with other foreign infrastructure firms at the micro level through critically evaluating the formation of local economic linkages. Second, INFRAFRICA explores the modalities of foreign engagement in the two African countries by investigating ways in which African state and nonstate actors negotiate with, accommodate, and contest foreign actors involved in the financing and building of infrastructure projects. Third, through exploring the political, institutional, economic, and legal contexts of the two countries, INFRAFRICA identifies the barriers that shape the negotiation, implementation, and outcomes of foreign-financed and foreign-built infrastructure projects in Africa. In carrying out my research, I will be based at the Robert Schuman Centre for Advanced Studies at the European University Institute, where I will work under the supervision of Professor Bernard Hoek
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Gene- Environment Interactions in Heart Development' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cardiovascular malformation (CVM) is the commonest cause of childhood death in developed countries. In the EU there are 51,000 new cases each year and two million affected individuals. Yet, despite intensive research, the cause of 80% of CVM remains elusive. The mission of CHeartED is to identify genetic and environmental pathways that can be modified with the goal of reducing preventable CVM incidence.  Epidemiological studies have shown that the stress of maternal hypo or hyperglycaemia increases the incidence of CVM. We plan a genetic association study in individuals with and without CVM born to diabetic mothers, to test whether genetic variants are associated with CVM. A similar study, without prior risk hypothesis, addresses tetralogy of Fallot, a CVM, which requires surgery in early life. These studies will reveal common genetic variants associated with CVM and thus add to existing knowledge on the aetiology of CVM. Moreover, the identification of genetic factors that differ in the context of maternal diabetes will disclose any associations in genetic pathways influenced by environmental factors. RNA expression studies in the mouse to identify new genes and pathways involved in outflow tract malformations and maternal diabetes associated with CVM, will complement the human studies. Finally, we will develop a 3D atlas of gene expression patterns and cardiac morphology at key developmental stages that will serve as a morphological framework.  Central to our proposal is the development of a bioinformatics tool complemented by an open-access Wiki-based database. The bioinformatics tool will combine the sequence data and expression data generated by the human and mouse studies with morphology and literature to prioritize genes and generate hypotheses. The Wiki, which w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Engineering of hybrid cells using lab-on-chip technology' (HybCell), addressing dissemination and exploitation.

assistant: **Impact**

The overall aim of the here described projects is to learn fundamental characteristics of cellular organization and compartmentalization, in particular the role of the lipid membrane, and to exploit this knowledge for engineering minimal cells with a great impact in the context of synthetic biology and also for pharmaceutical and medical applications. The first major objective aims at combining natural cell membranes with synthetic membranes to form defined hybrid systems with the size of cells or cell organelles. This approach has the intriguing advantage that the membrane receptors or channels are reconstituted in the hybrid cell and remain functional. In consequence, signaling pathways of a cell can be mimicked and therefore, the vesicles can be addressed similar to a cell or can serve as cell-free sensor. The second major objective addresses the challenge to build multi-compartment systems. In a defined number and formulation, smaller compartments are enclosed in a larger vesicle and carry other constituents than the lumen of the larger host vesicles (catalysts or enzymes, respectively; DNA; buffer systems; other active biomolecules). With the acquired fundamental knowledge on membrane permeability and fusion, multi-step reactions can be conducted, where several compartments are involved, just like in a living cell. The key methods to address these challenges are based on lab-on-chip technology that provide the unique potential to systematically investigate membrane properties by allowing precise formation, positioning, manipulation and analysis of the membranes; together with many more advantages such as the fast and controlled fluid supply, the possibility of tailoring the chemical surface patterns and surface topology and the application of electrical fields. Mic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Food security through ricebean research in India and Nepal' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Cereal production in S Asia has far outstripped that of legumes, with serious consequences for the food security and nutritional well being of poor farmers in marginal areas. Ricebean (Vigna umbellata) is a legume grown in Western, Northern and Eastern (WNE) India and Nepal but landraces predominate. It is grown as an intercrop, particularly of maize, and has been grown on residual water after rice. There is little or no choice of improved varieties as there has been almost non-modern plant breeding in the crop, and seed supply is limited or non-existent. Consequently, it is not grown widely despite being suitable for marginal areas where many poor people live. Established marketing channels do not exist.Ricebean grows well on many soils. It has rapid establishment, pest resistance, and potential for good yields of nutritious fodder and high quality grain, and this neglected crop has great scope for genetic improvement. We will utilise the partners' diverse capabilities to develop, test and promote farmer-friendly, profitable, sustainable interventions to integrate ricebean into maize- and rice-based cropping systems and legume markets in India and Nepal. We will assess genetic diversity in Nepal and India using participatory and molecular techniques, collect germplasm, and catalogue indigenous knowledge on ricebean diversity.We will elicit consumer willingness to pay for ricebean and assess its nutritional effects. We will carry out participatory agronomic trials to assess environmental adaptation. We will reach our overall objective of making ricebean more than locally popular by matching farmer-preferred varieties to diverse seasons, environments and market requirements, using a combination of genetic, agronomic, and socio-economic approaches firmly based on client-o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The global impact of coastal water contamination on economic development' under Horizon Europe.

assistant: **Concept**

Healthy coastal waters play a critical role for global food security. Worldwide, the ocean sustains the livelihood of more than 3 billion people, the vast majority of which live in low- and middle-income countries (LMICs). Worryingly, recent evidence shows that human contamination of coastal waters is having a significant impact on marine life. With a large share of communities relying on fishing for survival, it is likely that coastal water contamination is already disrupting local socio-economic development in LMICs. However, knowledge about this phenomenon remains highly limited. GLOBCOADEV will provide novel insights into the causal effect of coastal water contamination on economic development. Using a novel approach exploiting exogenous variation in coastal water contamination determined by rivers' release and by climate change, we will identify this effect for the last five decades and at a global scale for all LMICs. By gathering a wide array of micro-level datasets, ranging from household surveys to satellite imaging, and applying advanced micro-econometric techniques, we will pursue three major objectives: 1) to provide the first global evidence of the effect of coastal water contamination on early-childhood development, focusing in particular on the role of nutrition; 2) to determine how coastal water contamination affects local economic activities, concentrating on the pattern of fishing and on indicators of overall economic development; 3) to investigate side effects of coastal water contamination that are impacting local economic development, which include changes in political attitudes, the insurgence of violence, and rural-urban migration. GLOBCOADEV will not only fill an important gap in the literature, but also inform the design of policies protecting t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Biological diagnostic tools using microsystems and supersensitive magnetic detection' (BIODIAGNOSTICS), addressing dissemination and exploitation.

assistant: **Impact**

The objective of the proposed project is to develop new medical diagnostic tools based on the most sensitive detector technologies available today. A common denominator for the technologies is reading out the biological state in the magnetic domain. This will be accomplished by using both magnetic nanoparticles as substrates or tags for biological reactions and reading out the atomic nuclear spin. The latter technology is a development from the inductive readout in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). The technology used in this project is a pure magnetic field read-out system, which quite contrary to the inductive method has a sensitivity which is more or less independent of frequency and magnetic field down to very low fields. The several competing technologies will be benchmarked against each other with a model system consisting of biotin and streptavidine in order to gain a unique understanding of the differences and advantages with the different systems. To validate the concept(s), real diagnostic test will be done on in vitro detection of F1 antigen (y. pestis) Mycobacterium tuberculosis in urine samples and detection of Yersinia pestis F1 antigen in environmental samples (bio terrorism). Further to the validation, neuroimaging and instrumentation for diagnosis of neurological diseases will be investigated in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Designing advanced interfaces for the delivery and administration of location independent optimised personal services' in the context of a Sixth Framework call.

assistant: **Objectives**

Mobility has become a central aspect of the lives of European citizens - in business, education, and leisure. Due to rapid technological and societal changes, there has been a bewildering proliferation of technologies and services for mobile users. This has created a complex and confusing communications environment for both users and network operators. Further development of existing technologies, and the addition of new ones in Beyond 3G (B3G) systems, will necessitate a rethinking of fundamental technological issues in order to create user-centred and manageable communication infrastructures for the future.The vision of Daidalos is of a world in which:- Mobile users can enjoy a diverse range of personalized services- seamlessly supported by the underlying technology and transparently provided through a pervasive interface- Mobility has been fully established through open, scalable and seamless integration of a complementary range of heterogeneous network technologies.- Network and service operators start to make business and provide profitable services in such an integrated mobile world.The objective of Daidalos is to develop and demonstrate an open architecture based on a common network protocol (IPv6), which will be a significant step towards approaching the Daidalos vision. The overall Daidalos objectives are to:- Design, prototype and validate the necessary infrastructure and components for efficient distribution of services over diverse network technologies beyond 3G,- Integrate complementary network technologies to provide pervasive and user-centred access to these services,- Develop an optimised signalling system for communication and management support in these networks,- Demonstrate the results of the work through strong focus on user-centred and scenario-bas