RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Bridge to Canaan: Tell el-Daba (Egypt) in the Late Middle Kingdom, ca. 1820 to 1720 B.C.' to be submitted under Sixth Framework.

assistant: **Abstract**

Tell el-Daba-Avaris, the capital of the Hyksos rulers of Egypt, is one of the largest and most important sites for our understanding of the Near East in the Middle Bronze Age, because it provides evidence of a mixed culture with Egyptian as well as Canaanite components.The origins and history of the immigrants who helped to create this culture remain unclear. By assembling all the evidence available for a large area of settlement of late Middle Kingdom date, ca. 18201720 BC, excavated between 1966 and 1980 and unpublished, their history will be traced in all facets that can be gained from archaeological data.This will complement the scarce textual evidence existing for this period. First context groups within the excavation area will be assembled, consisting of metal and stone implements, animal bones, flint tools, shells, scarabs, archaeo-botanical remains and ceramics; to analyse them by application of statistical methods and interpret the results by comparison with similar purely Egyptian settlements.There are some well excavated sites belonging to the late Middle Kingdom-early Second Intermediate Period, ca. 19801700 BC, for comparison, such as Memphis, Dahshur, Lisht, Abydos, Thebes, Elephantine and the military forts in Lower Nubia, which will provide additional evidence regarding the architectural lay-out; settlement patterns; functional areas in the settlement; socio-economic issues like trade patterns and the life style of a non-elite community.This study will provide the first firm evidence for the beginning of the acculturation of Egyptian and Canaanite culture at Tell el-Daba, a process, which culminated in the Hyksos rule. It will provide a test case for interference theories in cultural studies.The research training with a group of innovative scholars at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A MET-TARGETED TYROSINE KINASE INHIBITORAS A NEW ANTICANCER DRUG' (METINHIB) targeting Sixth Framework.

assistant: **Abstract**

Advances made in recent years in identifying tyrosine kinases as signalling molecules governing proliferation and invasiveness have revealed the importance of their genetic alterations in the road to cancer. In particular, a little more than half of the known receptors tyrosine kinases have been repeatedly found either mutated or overexpressed in human malignancies, including sporadic cases. This has opened a whole new field of research aimed at developing new therapeutics by targeting tyrosine kinases. The success of Gleevec (an inhibitor for the Abl tyrosine kinase) in the treatment of Chronic Myeloid Leukemia has shown the potential of small molecule inhibitors as anticancer drugs. Furthermore, its rapid progress into clinical development has highlighted the importance of identifying the appropriate clinical setting for efficacy testing.We have preliminary evidence that an ATP-analog, known as a Trk inhibitor, may also be active on Met-mediated tumours. Treatment of nude mice carrying xenotransplants of a gastric carcinoma line over-expressing Met caused complete regression of the tumours after four weeks.We propose to further validate the anticancer potential of the drug in xenotransplants of other Met-positive tumour cell lines, and to ultimately test it in double transgenic mouse models for rhabdomyosarcoma and melanoma, two cancers for which there is a very strong rationale for causal involvement of the Met gene. The former is the most common solid tumour of childhood, and the latter is one of the fastest easing type of cancers in the world. Both tend to be particularly malignant and resistant to traditional therapy. The results of these pre-clinical tests may be critical in guiding the choice of patients for subsequent clinical trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Risk assessment for occupational dermal exposure to chemicals' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Skin diseases due to contact with chemicals form the largest group of occupational diseases, not even including diseases by uptake of chemicals through skin. However, little information is available on dermal exposure to chemicals. The proposal aims to reduce acute and chronic ill-health by developing a validated predictive dermal exposure model and a practical dermal exposure risk management toolkit for use in workplaces. To achieve this, a programme comprising four interrelated work parts, is proposed: qualitative survey of processes, tasks, populations and determinants of dermal exposure throughout Europe; quantitative assessment of potential dermal exposure for selected tasks; development of a predictive dermal exposure model; its validity will be determined with biological monitoring; development of a practical risk management toolkit for workplaces, to enable employers to rank dermal exposure risks and choose control measures.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SERIAL CRYSTALLOGRAPHY SOLUTIONS FOR SYNCHROTRON RADIATION FACILITIES' (Serial-X), addressing dissemination and exploitation.

assistant: **Impact**

Serial-X aims to expand of the use of serial crystallography across the academic and industrial life-science community by introducing low cost, flexible and easy to use solutions to the most common problems that occur in serial crystallography experiments today. Serial crystallography is a developing method of macromolecular X-ray crystallography that allows diffraction data to be collected at room temperature from a continuous stream of microcrystals. “ProtonPump”, the ERC Advanced Grant awarded to Richard Neutze, applies time-resolved serial crystallography to observe structural changes that occur during the reduction of molecular oxygen to water by cytochrome c oxidase. This PoC builds directly from technical solutions developed to achieve the scientific goals of “ProtonPump”. Serial crystallography was first developed at an X-ray free electron laser but is increasingly being used at synchrotron radiation facilities. Synchrotrons can potentially support up to two orders of magnitude more serial crystallography users than X-ray free electron lasers. Synchrotron based serial crystallography experiments may also become a mainstream method in structure-based-drug-design. But these possibilities will not be realized if the current lack of standardization in sample delivery continues, which is currently prohibitively expensive and requires a high level of technical support to operate. Serial-X will solve this problem by developing and bringing to market standardized, low-cost, flexible and easy-to-use solutions for sample delivery in serial crystallography studies at synchrotron radiation sources. Serial-X will thereby remove the greatest obstacle currently preventing scientists from using serial crystallography for their own research or for structure based drug-design wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Development of pregnenolone derivatives as allosteric inhibitors of CB1 cannabinoid receptors for the treatment of schizophrenia and psychotic syndromes'.

assistant: **Concept**

Excessive activation of the cannabinoid type-1 receptor (CB1) in the brain by synthetic, endogenous or plant-derived(cannabis sativa) cannabinoids can lead to pathological states, which could be ameliorated by blocking receptor signalling.However, due to the large number of functions involving the CB1 receptor, direct CB1 antagonist drugs induce side effectslimiting their therapeutic use. During the ERC-StG funded project, we found that a particular endogenous and labile lipidcompound, pregnenolone, acts as an allosteric and signal-specific inhibitor of CB1 receptors in the brain. Thus, stablepregnenolone-derivative drugs have been produced to exploit the therapeutic potential of allosteric inhibition of CB1 receptorsignalling, which can be used to decrease pathological over-activation of CB1 receptors. One clear pathological state whereover-activation of CB1 receptors plays a key role is schizophrenia and psychotic syndromes. Indeed, cannabis and syntheticcannabinoids can induce psychotic states and excessive CB1 receptor signalling has been proposed to participate in theetiopathogenesis of human schizophrenia. Thus, the present project aims at establishing the innovative and commercialpotential of this new class of drugs, stable derivatives of pregnenolone, as allosteric inhibitors of the CB1 receptor for thetreatment of psychotic syndromes.The following issues will be addressed:1. Technical activities will identify the compounds with the best therapeutic potential.2. Market studies will determine the potential competitiveness of these compounds.3. Additional industry partnerships will be sought for later stages of commercial development.By covering these essential steps bridging a scientific idea from basic research to therapeutic applications, the presentproject is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dynamic Energy System Services to Achieve Renewable Targets' in the context of a Horizon 2020 call.

assistant: **Objectives**

There is a niche opportunity in the electricity market across Europe for the provision of additional system/balancing services, decoupled from electricity generation, resulting from the rise in renewable generation. The innovative and unique approach is the development of hybrid-powered flywheels, synergising two proven technologies, flywheels and batteries and application to the electricity system for the first time, to provide security and stability. Hybrid-powered flywheels are resounding success in Formula1 motor racing for rapid acceleration. Schwungrad Energie plans to exploit the concept to enhance system security and stability. The advanced energy storage technology market is forecast to expand at a Compound Annual Growth Rate of 12.3% to €27 billion between 2012 and 2020.European countries are aiming to achieve low carbon energy systems by transitioning to renewable sources, to realise their European targets. This requires a higher penetration of intermittent, unpredictable generators (wind/solar). In Ireland, with high winds and relatively weak interconnection, the System Operator has proposed a new payment structure for additional system/balancing services, expanding the market. This makes Ireland an ideal location for the first hybrid-powered flywheel facility before market replication throughout Europe and worldwide as renewable penetration increases in other countries.Schwungrad Energie, an Irish company, was set up to successfully develop, operate and roll out facilities to provide system/balancing services in the electricity sector. The key personnel have expertise and experience in the technical, commercial, managerial and financial areas needed for project success and commercialisation within EU and beyond. Some have previous involvement with successfu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Effects of Different Learning Experiences on Automatic Evaluative Processes' (DLEAEP).

assistant: **Innovation**

In evaluative learning, associative learning refers to the effect of repeated exposure to an object and an evaluation that appear together (e.g., “Snakes-Unpleasantness”), whereas propositional learning refers to learning the actual relationship between the object and the evaluation (e.g., “Snakes cause unpleasantness”). A common core assumption in contemporary attitude research is that associative learning affects mainly automatic evaluations (unintentional and sometimes unconscious), whereas propositional learning affects mainly controlled evaluations (deliberated and conscious). However, contemporary attitude theory acknowledges some relationships across the implicit/explicit boundary. The proposed research will extend the investigation of these assumed relationships by examining another possible interrelation across the implicit/explicit boundary: the effect of non-associative information on automatic evaluations. The research will examine how learning specific object-evaluation relationships (e.g., “X causes unpleasantness” vs. “X prevents unpleasantness”) affect implicit measures and automatic evaluation. The research includes unprecedented large-scale (overall N > 30,000) comparative studies that will examine current assumptions about implicit/explicit distinctions in formation and measurement, in addition to the effect of propositional learning on automatic evaluation. It will use a large number of associative and propositional attitude induction methods, four difference implicit measures, and attitude-relevant automatic behaviors. These large-scale tests are possible because of the researcher’s involvement in an American research website that collects data from thousands of participants every week. At the same time, the research will test these questions in sma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'European Joint Doctorate Programme on Optical Sensing using Advanced Photo-Induced Effects'.

assistant: **Innovation**

Photonics is a key technology of the 21st century and has been identified by the European Investment Bank as being one of “the building blocks of the next digital revolution”. Photonics, with an expected world market of €615B by 2020, underpins all aspects of modern society, including optical telecommunications, biophotonics, medical technology devices and materials processing. Sensing is the largest application sector within European photonics; the compact, portable non-invasive potential of optical sensors makes them ideal solutions for industrial process analysis, environmental monitoring and food analysis. The strong industrial activity in Europe supports the employment of large numbers of highly qualified personnel, and with intense competition from China, USA and others, the demand for suitably qualified graduates has never been higher.Optical sensing is intrinsically a multi-disciplinary topic, requiring expertise in chemistry, physics and engineering; it is therefore ideally suited to a European Joint Doctorate programme. The OPTAPHI consortium brings together 5 world-leading research groups and 11 partner organisations to offer a cohort of 14 ESRs a unique opportunity; a PhD programme with cross-disciplinary training in both integrated photonics and advanced spectroscopy techniques, a double degree awarded by two of Europe's leading institutions and co-supervision by experts in each of the complementary fields. The network will focus on the cutting-edge technologies of Quartz Enhanced Photo-Acoustic Spectroscopy (QEPAS) and Photo-Thermal Spectroscopy (PTS) and includes an exciting programme of workshops, summer school and conference. OPTAPHI will demonstrate compact sensors that can be used in unmanned aerial vehicles for environment sensing, as low cost sensor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Campaigns for Awareness using Media and Publicity to assess the responses of individuals' (CAMPARIE) under Fourth Framework.

assistant: **Objectives**

1. To identify Information Management & Awareness Campaign (IMPAC) methods and strategies aiming at influencing travel behaviour in favour of sustainable transport modes and at enhancing the awareness of the public and the image and attractiveness of these.2. To record systematically and assess the future trends and perspectives for development of transport marketing through a pan European survey of transport decision makers and of publicity and media professionals.3. To develop a userfriendly computer prototype (MIRTO), orientated towards transport policy makers and marketing professionals, as a guide for optimal IMPAC strategies and as a tool for evaluating the effects of the various media used therein.4. To test in situ and evaluate innovative strategies for IMPAC aiming at the promotion of sustainable urban transport with and without the prototype.5. To elaborate recommendations and guidelines regarding the main features of IMPAC focusing on their purpose, content, target destinations, media and displays.6. To achieve a widespread dissemination of the project outcome within and beyond the Transport RTD Programme. %Nantes (FR)Patra (GR)Torino (IT)Case studies:Madrid region (ES) Thessaloniki (GR) Dormagen (DE) %Links with INPHORMM (main link), OPIUM, DANTE, WALCYNG, CAPTURE, TRANSPRICE, CONCERT-P projects from the Transport RTD Programme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'ProDUCTION TECHNOLOGY FOR QUALITY ASSURANCE AND IMPROVED RELIABILITY OF RESISTANCE PRESSURE WELDING' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The quality of resistance pressure welding joints, frequently used in a lot of applications (automotive industry, electrical appliances...) is influenced by various factors. Up to now it is impossible to detect during the welding process whether the strength of the welding point is sufficient. Having finished the welding process, even with non-destructive testing using ultrasonic waves or x-rays, good quality cannot definitely be verified. In particularly safety relevant areas random destructive testing is performed and additional safety points" are welded in order to guarantee that the overall strength of the joint is sufficient. The project aims at guaranteed reliable quality assurance which does not only allow to recognize defective joints during the welding process but also allows to avoid defective joints by on-line interferences (feedback control) during the welding process. Through such a technology it could be expected to reduce drastically the destructive testing, to save time in quality assurance and production (up to 25%) and to improve the welding quality. Well-known methods of artificial intelligence from other areas, especially neural networks shall be employed to evaluate on-line the input data of the welding control system (current, voltage and possibly electrode power) for quality assessment.The quality assurance mechanisms shall be cost effective and capable of being integrated in future control systems without expensive sensor technology. In the case of success there will be a great market in Europe for producers and users of the system and a good opportunity for SMEs in Europe to increase their competitivness."