RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Magnetic cross-modal brain activity scanner MAX-BAS' (MAX-BAS).

assistant: **Innovation**

This Innovation Launchpad proposal aims at commercializing the first cross-modal MEG-MRI scanner. Our superconductor-based detector system is used for both magnetoencephalography (MEG) and magnetic resonance (MR) to achieve imaging (I) of brain activity overlayed accurately with anatomical brain images. In the FET Open project BREAKBEN, we are finalizing our research prototype and demonstrating the commercial potential with patients and healthy subjects. The next step is to aim for the markets, which requires careful assessment of the accuracy of the device and measures to further standardize and automate the MRI procedures.This will also lead to the first commercial implementation of ultra-low-field MRI, measured in microtesla-range magnetic fields. In addition to the synergy with MEG, this type of MRI enables unique advantages compared to conventional MRI, including improved contrast for tumors, and an extremely safe and open scanner that is potentially completely silent. Cross-modal MEG-MRI provides useful information for both research and for clinical use.


**Keywords:** imaging, brain, MEG-MRI, neuroscience, superconductor, biomagnetism, SQUID
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Energy Optimisation in European Greenhouses' (GREENERGY).

assistant: **Innovation**

Unlike field agriculture, which bases production costs on hectares, greenhouse costs are calculated on a per-square meter of growing area or on a per plant basis. The production costs represent around 78% of the total chain costs in greenhouses, being energy consumption the main factor affecting those expenses. It is estimated that greenhouses cover an area of about 41000 ha in the European Union, setting Europe as the biggest supplier of greenhouse products in the world. At the same time, as Eastern European markets open up, the EU is also becoming the biggest consumer of greenhouse products in the world. However good the situation may seem the competitiveness of European growers is threatened by the increasingly higher costs of fuel and the competition of external growers producing at low costs. A reduction in the production costs of commodities will help the European greenhouse producers to retain their position in the European market where internal transportation costs are significantly lower than those of external competitors.The most important aspect of the production that can be improved to reduce costs is energy consumption. Therefore, an optimisation of the energy consuming systems and operating procedures in existing greenhouses will reduce production costs enabling European greenhouse growers to remain competitive in the European market. On the other hand, reducing the energy consumption in their facilities will help farmers face the increasingly restrictive environmental regulations affecting the sector.In this project, it is intended to investigate the greenhouse energy requirements for different areas in Europe. A tool for auditing energy efficiency in greenhouses, a set of technical improvement measures and a guideline for the optimisation of energy consu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Euroconf-inv'.

assistant: **Innovation**

The EuroConference Recent Development In The Wave Field And Diffuse Tomographic Inverse Problems" focuses on the latest mathematical research of inverse problems that originate from wave field or tomographic inversion applications. In these applications, the goal is to retrieve information from an inaccessible region by probing it with wave fields (typically electromagnetic, acoustic or elastic waves) or by monitoring diffusion through it (typically electric current, near infrared light or heat flows). In recent years, the mathematical research around these problems has been intensive and completely new approaches to solve these challenging problems have emerged. Examples of such new approaches to solve these challenging problems have emerged. Examples of such new approaches are the use of differential geometric methods and techniques of control theory for partial differential equations. This research has also a strong impact on the research in applied and industrial sector."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Natural products from marine fungi for the treatment of cancer' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The aim of MARINE FUNGI is the demonstration of sustainable exploitation of marine natural resources providing appropriate culture conditions for the underutilised group of marine fungi, thus enabling efficient production of marine natural products in the laboratory and also in large scale cultures, avoiding harm to the natural environment. The focus of MARINE FUNGI are new anti-cancer compounds The project will carry out the characterisation of these compounds to the stage of in vivo proof of concept ready to enter further drug development in order to valorise the results of the project.MARINE FUNGI covers two approaches to gain effective producer strains:a) Candidate strains originating from one partner’s strain collection will be characterised and optimised using molecular methods.b) New fungi will be isolated from unique habitats, i.e. tropical coral reefs, endemic macroalgae and sponges from the Mediterranean. Culture conditions for these new isolates will be optimised for the production of new anti-cancer metabolites.MARINE FUNGI will develop a process concept for these compounds providing the technological basis for a sustainable use of marine microbial products as result of “Blue Biotech”. The project will explore the potential of marine fungi as excellent sources for useful new natural compounds. This will be accomplished by the formation of a new strongly interacting research network comprising the scientific and technological actors, including 3 SMEs and 2 ICPC partners, necessary to move along the added-value chain from the marine habitat to the drug candidate and process concept. The generated and existing knowledge will be disseminated widely for the valorisation of the project results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Refined invariants in combinatorics, low-dimensional topology and geometry of moduli spaces' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Some invariants appearing in low-dimensional topology and algebraic geometry admit a so-called refinement: a much stronger, but more complicated invariant. For instance, in low-dimensional topology we study the Poincare polynomial of the triply-graded Khovanov-Rozansky homology of a knot, which is a refined version of the HOMFLY-PT polynomial. The usual Poincare polynomial and the E-polynomial of a character variety are refined by the full mixed Hodge polynomial. On the cohomology of a moduli space of Higgs bundles, we need an extra filtration, the so-called perverse filtration, to define the refinement. Where classical invariants produce polynomials in one variable q, and often have expressions involving Schur polynomials, refined invariants produce polynomials in two variables q and t, and often have expressions involving Macdonald polynomials. The connection conjectures and the P=W conjecture relate refined invariants appearing in the three contexts above.We propose to develop a comprehensive theory connecting these notions, and as main applications, to solve the P=W conjecture for character varieties, the Gorsky-Negut-Rasmussen conjectures relating knot invariants and sheaves on the Hilbert scheme, Cherednik's conjectures computing homologies of algebraic links via DAHA, the Hausel-Letellier-Rodriguez-Villegas conjectures computing mixed Hodge polynomials of character varieties, nabla positivity, and the Stanley-Stembridge positivity conjectures.To achieve our goal, we will build on methods developed in our previous work on the solution of the shuffle conjectures, the computations of homology of torus knots and Poincare polynomials of character varieties, and the proof of the curious hard Lefschetz conjecture. These methods include combinatorics of Dyck paths, symme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fairground Attraction - Molecular Machines' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

We will construct molecular assemblies (machines) of unprecedented complexity leading to unique function. The machines will be anchored to surfaces, like their macroscopic counterparts, and are molecular variants of familiar fairground attractions the ‘Big Wheel’ and ‘Teacups’ ride. The functional units which make up the assemblies are phthalocyanines and porphyrins such that they are themselves multichromophore arrays designed to allow energy and electron transport to and from a metal surface. There are possible applications of these structures including potential for multielectron processes of relevance for new generation energy capture systems, molecular computing, data storage and security. The challenge is to construct, in a controlled manner, complex assemblies using recently described chemistry from the hosting group as a starting point. This new chemistry, which allows the controlled construction and functionalisation of silicon, gemanium and boryl macrocycles, makes such assemblies achievable for the first time. The molecules are aesthetically beautiful and likely to capture the imagination of the wider scientific community. Characterisation and evaluation of these entities will be a crucial aspect of this programme and will be important to determine the potential of this approach for constructing functional molecular device components. Surface bound assemblies/machines will be characterised spectroscopically, electrically and microscopically. Preliminary function will be interrogated using time resolved spectroscopy, electrochemistry and interfacial charge injection processes, and spectroelectrochemistry. The programme combines high-impact research with exposure to wide-ranging training and experience. In addition to new synthetic techniques and protocols, the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Tissue Cytokines at the Nexus of  Immune Cell-Cardiac Stromal Cell Interaction' to be submitted under Horizon 2020.

assistant: **Abstract**

Myocarditis is an acute inflammatory heart disease that can progress to chronic cardiomyopathy and heart failure. Since there is no specific treatment recommendation available for myocarditis and subsequent inflammatory cardiomyopathy, there is an urgent need to dissect the pathological principles underlying cardiac inflammation and to target those molecular pathways that are at the core of the pathological process.My recent research places cross-reactive CD4+ T cells at the center of inflammatory cardiomyopathy pathogenesis. The activation and sustenance of cardiotropic T cells is controlled in immune cell-nurturing niches that are generated by fibroblastic stromal cells through the provision of tissue cytokines of the TGF-beta superfamily. The overarching goal of this project is therefore to decipher the molecular pathways that govern the interaction of immune cells with stromal cells in the cardiac tissue through the combination of state-of-the-art pre-clinical models, novel methods from quantitative systems biology, functional validation by antibody blockade, and assessment of the translational relevance through the analysis of cardiac biopsies from human patients. The generation of antibodies that neutralize a distinct set of tissue cytokines or their inhibitors will not only serve as functional validation, but will open possibilities for future translational development. Moreover, the utilization of spatial transcriptomics for the analysis of human heart samples will open new avenues for innovative research both in immunology and in cardiology. Overall, I expect that the planned research program will deliver (i) novel targets for the treatment of myocarditis and inflammatory cardiomyopathy, (ii) validated prototype antibodies that ameliorate cardiac inflammation t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A geologic approach to resolving critical uncertainties in the impact of geomagnetic variance on in-situ cosmogenic nuclide production', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Accurate prediction of future climate impacts hinges upon the robust reconstruction of past climate change. Palaeoclimate records serve as benchmark data for modern climate models and are a key element of model validation. Glaciers in particular are sensitive indicators of climate, providing geologic records of past climate fluctuations in the form of moraines. Recent advances in cosmogenic nuclide (CN) surface-exposure dating now allow these landforms to be dated directly, opening glacial geology as a potentially rich global archive of past climate change. However, fundamental limitations in our ability to exploit glacial records as a climate proxy are uncertainty in the 1) variance of CN production rates over time and 2) validity of numerical frameworks used to account for potential production rate variation. I propose to address these challenges directly by developing CN production rates for multiple periods from a single region in the tropics, where the theoretical impact of production rate variability is greatest. I will work with geochronologist Dr. Gordon Bromley of the host institution, National University of Ireland, Galway, to implement my field-based campaign in the Peruvian Andes, where I will map and sample volcanic deposits for CN calibration. I will be trained in noble gas mass spectrometry by Dr. Pierre-Henri Blard at partner institution Centre de Recherches Pétrographiques et Géochemiques, France. My ultimate fellowship goal is to refine and strengthen the surface-exposure dating technique in order to open the glacial geologic record as a global proxy for past change. Crucially, the results of my proposed research will provide both myself and the wider scientific community with the cutting-edge toolset required to apply cosmogenic nuclides to deposits o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Methods for structure determination by multi-dimensional solid state nuclearmagnetic resonance spectroscopy' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The principle problem involved in the determination of structural information by NMR spectroscopy is that of overcoming the extreme complexity of the spectra obtained from abundant spins. I propose to develop multi-dimensional solid state NMR techniques to simplify dramatically the spectrum. The techniques are based on proton detected dipolar local fields. Such techniques have recently been shown to be powerful structural probes in oriented systems, but are much more limited in their application to powdered samples. I propose to introduce improved pulse sequences which will extend the use of these techniques to the measurement internuclear distances in powders. I propose to do this using ideas adapted from a series of recent demonstrations which show that under certain circumstances the NMR behavior of a powder can be made to mimic that of a single crystal. The proposed formalisms and techniques should also have implications for improving the sensitivity and resolution of solid state NMR through their application in other areas such as cross polarization and heteronuclear decoupling. The ideas presented represent a significant step towards the determination of molecular structures in solids by NMR.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Collective dynamics in particle laden lamellae' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Particle laden fluids are of fundamental and contemporary interest due to the recent perspectives of understanding their flows. This research project endeavors to understand the collective behavior of solid particles suspended in fluid lamellae at multiple scales with relevance to aqueous foam. We aim to delineate the concurrence of distinct influences that have thus far been primarily studied in either bulk or single interface studies. These aspects include recent perspectives such as particle jamming in granular media, shear banding/localization in colloidal systems, aggregation dynamics, transitions from thermal to athermal dynamics and the influence of surfactant physical-chemistry. While these phenomena have been studied in 2-dimensional and 3-dimensional spaces, the influence of curved spatial manifolds is expected to exhibit novel and rich phenomenology. Fluid lamellae in are ideal candidates to study many of these phenomenon as a function of spatial curvature. Particle laden foam is also recently being used as precursors to building solid materials. The control of many aspects of the fabrication process relies on an understanding of particle dynamics at the lamellar scale. The proposal outlined here will understand fundamental mechanisms involved in these processes. In the return phase(India), we propose to further the understanding of foam in along with particle inclusions in the regime of impacts. This is expected to be a productive avenue of research as foam and particle inclusions can have multiple relaxation times. At low velocities (impact time >> material relaxation time), impacts are expected to distribute energy over a wider area of the target, however at high velocities (impact time << material relaxation time) the energy is strongly focused at the poi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'cooperation between BCL6 and c-Jun in lymphoma development and progression'.

assistant: **Objectives**

Sequential activation of different oncogenes drive the step-wise progression of precancerous cells to highly malignant tumors. A molecular understanding of the transformation events is crucial to develop anti-cancer therapies. In this sense, The AP-1 transcription factor has gained special attention in the last decades due to its key role in the tumor development. AP-1 comprises a family of dimeric basic region-leucine zipper transcription factors. The founding members of the AP-1 family, c-Fos and c-Jun, were both originally identified as oncogenes. C-Jun is the most potent transcriptional activator in its group. The induction of AP-1 by pro-inflammatory cytokines and genotoxic stress is mostly mediated by JNK that mediates c-Jun N-terminal phosphorylation in its transactivation domain, increasing the transcription of target genes. The B-cell Leukemia-6 (BCL6) proto-oncogene encodes a transcriptional repressor required for the formation of Germinal Centers (GC) which are important in pathology, since GC B cells are thought to represent the cell of origin of most types of human B cell lymphomas. Transgenic mouse overexpressing BCL6 have been generated and they could not fully recapitulate the human disease, suggesting that cooperation with a second oncogene may be required. Previously it has been observed that c-Jun and Bcl6 physically interact, however the significance of this interaction for tumour development was not investigated. The host lab has recently confirmed the association of c-Jun and BCL6 and in this proposal we will investigate whether c-Jun activation cooperates with BCL6 in lymphoma development. A multidisciplinary study, including in vitro and in vivo approaches will be used to define the nature of the cooperation between BCL6 and c-Jun in lymphoma dev