RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Deciphering Alzheimer’s disease molecular subtypes to advance treatment development.' to be submitted under Horizon Europe.

assistant: **Abstract**

Worldwide, 50 million people suffer from dementia, which is caused by Alzheimer’s disease (AD) in 70% of the cases. There is no treatment to stop, reverse or prevent AD. AD is pathologically defined by amyloid plaques and tau tangles in the brain, implying that it is a single disease entity. Still, patients vary greatly in rate of decline and underlying pathophysiology, which hampers the search for cures. I have discovered and replicated 5 AD subtypes in patients based on cerebrospinal fluid proteomics (CSF). Subtypes had distinct pathophysiology, including differences in amyloid metabolism and clearance, as well as in cognitive decline. This indicates that they would need tailored treatments.The goal of this project is to understand AD subtype specific mechanisms, and how these are related to cognitive decline, taking CSF proteomics as a starting point. I will address the following scientific needs:1. Understand which AD subtype molecular processes change over time, and how those changes relate to cognitive decline. This requires large datasets of individuals with repeated CSF proteomics. I have access to two large, deeply phenotyped cohorts with already collected repeated CSF samples over 5 years from 700 individuals, in which I will measure proteomics.2. Study drivers of AD subtypes with genetics and in a subset of n=50 with tissue proteomics.3. Develop markers in blood for subtype detection, which would remove barriers for clinical use.4. Test if AD subtypes differently respond to amyloid modifying drugs, which is the strongest proof that AD subtypes need tailored therapy.If successful, DecipherAD will provide proof of concept that AD subtypes have use as a theragnostic tool, show which genetic factors drive molecular subtypes, how molecular signatures change over t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Modern Bigness : Challenges for European Competition Law' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The influence of large tech-companies in society is undeniable. The emergence and development of the digital economy marks a paradigm-shift towards a more connected and fluid platform society. New challenges stem from rapid technological developments, the combination of economic and digital power, and arise from a combination of unprecedented data-collection and the indispensability of pivotal platforms for both market-participants and citizens. This impacts both markets and democracy. Even though the challenges are urgent, law struggles to find answers. This is true also for European competition law, which aims to combat the negative effects of market power. However, as is hypothesized here, powerful tech-companies give rise to a new type of power: Modern Bigness. It impacts both market values and non-market values, such as freedom and democracy. The MOBI project investigates whether European competition law can and should tackle the challenges of Modern Bigness, arising from the digital economy. It will first develop an original theory of Modern Bigness. A case study on hypernudging digital platform-users and autonomy, and a case study on access to platforms by using the essential facilities-doctrine or public utility theory will highlight the entwinedness of market and non-market impacts, while a third study evaluates whether the power of Modern Bigness itself could be under threat by the disruptive impact of blockchain-technology. The overarching research question is answered by considering the response to the question whether European competition should tackle the multifaceted challenges of Modern Bigness within a normative framework building upon European constitutional theory and the nascent field of technology regulation.The project fundamentally reconsiders the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms of MTOC guidance and Genetic Transfer at the Immune Synapse: novel modes of Immuno-modulation.' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Cell-cell synapses are an exquisitely evolved means of communication between cells. During the formation of the immune synapse (IS), diverse transmembrane and membrane associated molecules are reorganized into a highly segregated structure at the T cell–Antigen-Presenting Cell (APC) contact site. As part of this process, the tubulin cytoskeleton is vectorially directed toward the center of the IS, where the microtubule-organizing center (MTOC) localizes. MTOC translocation is an early event in IS formation that brings the secretory apparatus into close apposition with the APC, thus providing the basis for polarized secretion.The proposal aims to define how the MTOC controls cytoskeletal rearrangement and communication at the IS, as a mechanism for macromolecule transport and nucleation of signalling molecules during synaptic contact. We will study the mechanisms of MTOC-mediated polarization of multivesicular bodies (MVB) and exosome delivery during IS formation, and will assess the role in these processes of MTOC translocation regulators (HDAC6) and microtubule (MT) polymerization promoters (Plk1 and EB1). MTOC-dependent mitochondrial polarization to the IS will be assessed as a bioenergetic source for cytoskeletal rearrangements, IS maturation and polarized exosomal delivery. In particular, our proposed study of the possible horizontal transfer of miRNAs during cognate interactions between immune cells has the potential to reveal how miRNAs can control the early initiation of immunity. We will investigate the mechanism of directional transfer of RNA-harbouring exosomes at the IS from T cell to APC, and will examine the functional consequences of this transfer on APC biology and on the immune response. These studies will open avenues for the treatment of immune-related
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Orchestrating the Transcriptome and Proteome in Time and Space:Quantitative Modeling of Protein Production, Degradation and Localization in Mammalian Systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Gene expression in mammalian cells is tightly controlled and depends on the interplay between the production, degradation and localization of RNA and proteins. Each of these processes is highly regulated, but it remains largely unclear which of these is the dominant process determining the final concentration of each protein in each cell state or time point on a genomic scale.In my outgoing phase, I will systematically study the dynamics of gene expression control of mammalian cells, using the clinically-relevant model system of immune dendritic cells (DCs) responding to the pathogen component LPS. First, I will evaluate the contribution of protein production and degradation to changes in overall protein levels following LPS stimulation. Second, I will integrate the generated data with already available data about the dynamics of the RNA life cycle to build an unprecedented quantitative genome-scale model of the temporal dynamics of gene expression, from transcription to protein degradation. Third, I will study systematically the translational potential of short non-canonical ORFs encoded on putative long non-coding RNAs. Finally, I will use these data to select new candidate regulators of the immune response of DCs and validate and refine their roles by systematic genetic perturbations followed by signature-scale monitoring.In my returning phase, I will apply the experience gained and methods developed during my outgoing phase to systematically study gene expression in hippocampal neurons upon synaptic stimulation. In particular, I will study gene expression control in somata and dendrites separately, thus considering spatial and temporal regulation of gene expression dynamics.The proposed study will provide insight into the temporal and spatial expression dynamics of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum dynamical neural networks', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Quantum neural networks are a young research field, that has been rapidly expanding due to their potential to attain revolutionary computing capacities and the possibility to learn on quantum data, inaccessible to classical computers. However, despite impressive proof-of-concept results, currently existing approaches that rely on sparsely coupled qubits, are not scalable to network sizes and connectivities with tunable weights required for state-of-the art tasks. In qDynnet, I will adopt a completely new and unexplored approach that uses parametrically coupled superconducting quantum oscillators instead of physically coupled qubits, that will allow me to obtain quantum neural networks of unprecedented size, connectivity and tunability. To do this, I will shift the paradigm by implementing neurons as basis states of dynamically coupled multi-level quantum oscillators, and connections between neurons as transition rates obtained through different dynamical processes such as parametric coupling, resonant drives and dissipation.  I will implement experimentally quantum neural network architectures that were only simulated until now and use them to demonstrate data classification with basis state neurons. In order to go towards more complex tasks, I will use parametric coupling to introduce tunable connections between neurons. I will develop new training methods that will allow me to tune connections in such dynamical quantum neural networks and use them to demonstrate learning to recognize quantum states. I will develop circuit geometries that will be scalable to large quantum neural networks with millions of neurons and tunable connections. The qDynnet project will provide understanding of physics, and methods for dynamical coupling and training, that will have a broad imp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The emergence of new industrial activities: fusing services and manufacture' to be submitted under Fifth Framework.

assistant: **Abstract**

This project is about structural change in European industry resulting from rapid innovation at the interface of knowledge-based services and technology-intensive manufacturing. It focuses on three hybrid sectors in the areas of electronic commerce, business data communication and multimedia in order to appraise the factors underlying their emergence and early evolution.This research purports to add value to the current state-of-practice by: a) using an imaginative approach to empirically analyse structural change at strategic corners of European industry,b) examining emerging hybrid sectors across several countries, c) assembling indicators to build early warning systems" for emerging hybrid sectors across several countries, d) providing valuable policy advise on how to create the socio-economic conditions to nurture such activities."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Engaging SMEs with IST related European Technology Platforms' (EPISTEP), addressing dissemination and exploitation.

assistant: **Impact**

EPISTEP will enable SMEs participation in the FP6 and FP7 according to the Economic and Technological Intelligence guidelines with the goal to explore how to enhance their presence in the three IST European Technology Platforms (ETP), namely mobile communications, embedded systems and nano-electronics. This objective will be realised through two different paths, viz a web based portal to facilitate the exchange and sharing of information as well as contacts among SMEs operating in these three areas and organisation of missions, brokerage events, workshops and technical assistance. Main activities are :1 Establish formal cooperation agreements with each of three ETPs.2 Identify and contact of SMEs operating in the market sectors of mobile communications, embedded systems and nano-electronics3 Raise awareness of SMEs of their specific interests and capabilities of operating in the IST ETPs4 Appraisal of the capability of SMEs to successfully operate in this evolving market sector5 Provide an ongoing interface with the three IST ETPs by establishing an open, broad third tier cooperation framework to provide two way access between the platforms and the broader related SME population6 Identify IST ETP projects and calls for proposals of interest to the identified SMEs7 Identify roles SMEs can play in IST ETPs8 Realise a web portal to facilitate and optimise support and dissemination activities9 Awareness and training of SMEs through the organisation of national workshops and training sessions10 Engage SMEs with ETPs by taking them on missions to meet platform members11 Organise trans-national brokerage events and other partner-search activities12 Technical assistance and help desk for SMEs in the proposal and contract preparation phases13 Ongoing dissemination and exploitati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of an Integrated MEMS (Micro Electro Mechanical System) based DNA Analysis Chip with Active Flow Control Components' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Inherited human genetic characteristics govern the way people may be affected during their life from cardiovascular diseases, cancer, and drug response. These illnesses represent the first three cause of death in worldwide population. The knowledge of genetic factors affecting human susceptibility to genetic-related diseases could enable physicians to safely adapt treatment to each patient. State-of-the-art techniques still suffer from time-consuming and labour-intensive procedures, which require costly and bulky equipment, as well as great quantity of costly reagents, taking several hours to deliver results. Due to needed tedious steps, these processes are also specially prone to human error. The development of rapid, low expensive and high-reliable methodology aimed at providing accurate information related to hundreds of genes in a few minutes is strongly deemed.The SMART-BioMEMS project aims to develop a novel DNA chip with fully integrated functionality, including sample preparation, amplification, gene detection and data processing, ideally suited for ultra-fast, cost-effective point-of-care genetic analysis. Latest advances in MEMS (Micro Electro Mechanical System) technology will be addressed, possessing the appropriate potential to enable complete DNA analysis, with increased functionality and performance, at reduced costs due to the optimised consumption of costly reagents. As well, innovative active flow control elements will be integrated with the chip to precisely move minute amounts of DNA sample and reagents in a controlled way, thus maximising the performance of the whole lab-on-a-chip system.Finally, advanced optical flow visualization techniques, including micro-PIV (Particle Image Velocimetry) and LIF (Laser Induced Fluorescence), and special micro-fl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Results and prospects of research projects on small ruminants in africa' (1998-2002).

assistant: **Innovation**

The meeting on small ruminants in Africa" is a satellite symposia of CAPRI 2000 (international conference on goats at roars on 15-18 may 2000). It will be hold at potters on 20 may. The objective is to present the main results of the small ruminants projects in Africa : "Sissonville" project sponsored by DG12 EU regional project of research on small ruminants in Chad, sponsored by French Cooperation, disease and productivity of small ruminants project in Senegal sponsored by CIRAD-EMVT and ISRA and small ruminant project in Southern Africa. This meeting will be able to propose some recommendations for development of the small ruminants production."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Commercial assessment of a novel protocol for epilepsy characterisation with temporally interfering electric fields'.

assistant: **Innovation**

The ERC StG project “Epilepsy Controlled with Electronic Neurotransmitter Delivery (EPI-Centrd)” is focused on improved therapeutic intervention in drug-resistant patients with surgically-complicated forms of epilepsy. These patients represent a large demographic needing new commercial solutions, as there are fifty million people in the world with epilepsy and up to 50 cases of new-onset epilepsy per 100,000 people each year, where 30% of these cases are patients with drug-resistant epilepsy. Although EPI-Centrd provides state-of-the-art treatments for epileptic zones in the brain of drug-resistant patients, it does not include technology for improved identification of such epileptic zones. This ERC PoC project “The Commercial Assessment of a Novel Protocol for Epilepsy Characterisation with Temporally Interfering Electric Fields (CONECTIF)” dramatically improves the traditional limitations in the identification of epileptic zones in the brain of patients by providing a simplified, less-invasive method capable of localizing epileptic tissue, including the ability to non-invasively investigate previously inaccessibility and surgically-complicated brain regions. The new method utilizing temporally interfering electric fields could have a massive commercial potential and, if successful, would dramatically improve the therapeutic targets for technologies developed in the EPI-Centrd project and for the identification of epileptic zones in other forms of epilepsy, not only in drug-resistant patients.


**Keywords:** Epilepsy,  Electrophysiology,   Identification of epileptogenic zones,  novel protocols in epilepsy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Extensible Processing Units (XPUs) as Enablers of the High-Performance Low-Power Embedded Market' under Horizon 2020.

assistant: **Concept**

According to Frost & Sullivan (2017),  https://store.frost.com/global-autonomous-driving-market-outlook-2018.html,  in 2024 there will be in Europe more than 1.5 million cars which will have at least conditional automation with each car requiring an average of about 2000€ in chips to enable automatic driving. Thus the total available market in Europe will reach 3000M€ in 5 years with a robust CAGR of 30%. Markets in USA and China will be of similar size.The requirements for Level 5 autonomous cars (fully-autonomous vehicles with performance equal to that of a human driver in every driving scenario including extreme environments) will require substantially high processing power not currently available with today’s microprocessors. Processors in future cars not only must deliver increasing higher computing power but also they must do so as efficiently (low-power) as possible given strict automotive safely constraints.  Furthermore, fully-autonomous cars require robust real-time features and dynamic balance between safety, performance and power. In contrast, current microprocessors are either high-performance but are not power efficient (e.g., Intel), or are low-power but unable to reach top performance (e.g., ARM), and generally do not have a strong real-time capability. These key bottlenecks are hindering advances towards fully automated vehicles. MOSAIK has defined a novel modular architecture designed from the ground-up to solve these urgent challenges. To keep European Industry leadership (https://www.mckinsey.com/industries/automotive-and-assembly/our-insights/a-long-term-vision-for-the-european-automotive-industry) setting the framework for car connectivity and user experience is a must. And to do so European industry needs a European Semiconductor company able to r