RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A testbed digital library infrastructure on grid enabled technology' (DILIGENT) under Sixth Framework.

assistant: **Objectives**

The main objective of DILIGENT is to create an advanced test-bed that will allow members of dynamic virtual e-Science organizations to access shared knowledge and to collaborate in a secure, coordinated, dynamic and cost-effective way. This test-bed will be built by integrating the Grid and Digital Library (DL) technologies. Merging of these different technologies will lay the foundations for a next generation e-Science knowledge infrastructure. The DILIGENT infrastructure, which will build upon the efforts of the EGEE project (IST-2003-508833), will serve many different research and industrial applications.The test-bed will be demonstrated and validated by two complementary real-life application scenarios: one from the cultural heritage domain and one from the environmental e-Science domain. Additional objectives of the project are:- to open up Grid technology to a broader range of research and industrial communities;- to broaden the diffusion of DLs by supporting a cost-effective DL operational model;- to promote cross-fertilization between the DL and Grid technology domains that will foster advances in both the areas.In order to achieve its objectives, DILIGENT has identified four main areas of work:- integration of DL services and content together with third-party applications as OGSA-compliant Grid services;- experimentation with real-life user communities;- feedback with respect to the capabilities of the Grid and the design of DL system architectures;- exploitation and sustainability.Two prototypes will be released during the project. The first one, which will run on a restricted Grid infrastructure, will be used to achieve a sufficient level of confidence about the technology and will demonstrate the feasibility of implementing a system that offers DL functional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structure Preserving schemes for Conservation Laws on Space Time Manifolds' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

SuPerMan proposes the development and efficient implementation of new structure preserving schemes for conservation laws formulated in an elegant and universal form through covariant derivatives on spacetime manifolds.Indeed, nonlinear systems of hyperbolic PDEs are characterized by invariants, whose preservation at the discrete level is not trivial, but plays a fundamental role in improving the long term predictivity and reducing the computational effort of modern algorithms. Besides mass and linear momentum conservation, typical of any Finite Volume scheme, the preservation of stationary and moving equilibria, asymptotic limits and interfaces still represents an open challenge, especially in astrophysical applications, such as turbulent flows in gas clouds rotating around black holes.In this project, our focus will thus be on General Relativistic Hydrodynamics (GRHD) for which such Well Balanced (WB) Structure Preserving (SP) schemes have never been studied before. In particular, we plan to devise smart methods, independent of the coordinate system. This will be achieved by directly including the metric, implicitly contained in the covariant derivative, as a conserved variable inside the GRHD model.This approach will first be tested on the Euler equations of gasdynamics with Newtonian gravity, extending already existing WB-SP techniques to general coordinate systems. All novel features will be carefully proven theoretically. Next, the new schemes will be incorporated inside a massively parallel high order accurate Arbitrary-Lagrangian-Eulerian Finite Volume (FV) and Discontinuous Galerkin (DG) code, to be released as open source. The feasibility of the project is guaranteed by the strong network surrounding the ER, including experts on WB-SP techniques and mesh adapta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'NITEC: a Negative Ion Time Expansion Chamber for directional Dark Matter search' (NITEC).

assistant: **Innovation**

The goal of this project is the construction of a Negative Ion Time Projection Chamber (NITPC) with triple Gas Electron Multiplier amplification and pixel readout (GEMPix) for directional Dark Matter (DM) searches. DM is 5 times as prevalent as normal matter in the Universe, but its identity remains unknown. Its mere existence implies that our inventory of the basic building blocks of nature is incomplete: deciphering its nature is one of the most compelling tasks for fundamental physics and astronomy. Weakly Interacting Massive Particles (WIMP) are well motivated DM candidates, independently predicted by Standard Model extensions and Big Bang cosmology. Direct detection experiments aim at observing very low energy (10-100 keV) nuclear recoil of WIMP scattering in the matter. While today leading experiments have managed to reach excellent rejection for electromagnetic components, other background sources (such as neutrinos and environmental radioactivity) will forbid to even think larger mass next-generation detectors without a drastic change in technology. We believe that the combination of the large volumes and improved position and energy resolution provided by the negative ion technique, together with the excellent performances of the GEMPix can offer a significant contribution to this research field. In a NITPC, negative ions drift rather than free electrons, drastically reducing diffusion thanks to their higher mass. This is why we want to combine for the first time this idea with one of the most advanced readout, the GEMPix: a triple GEM detector coupled to a Medipix ASIC board, able to provide excellent spatial, energy and time resolutions. Its sensitivity to single ionization cluster will allow this NITPC, together with the slow motion of the anions, to functio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Long-read sequencing to resolve the missing heritability in patients suspected of PTEN hamartoma tumour syndrome'.

assistant: **Objectives**

Individuals with a genetic tumour risk syndrome are at high risk to develop cancer. One of these syndromes is PTEN hamartoma tumour syndrome (PHTS). PHTS is associated with pathogenic variants (PVs) in the PTEN gene. Unfortunately, in the majority of patients suspected of PHTS no PV in PTEN is identified. These patients are considered PHTS-like. The low diagnosis rate in this group of patients suggests the possibility of PVs in regions of PTEN that are not covered in routine diagnostics or suggests that PVs in other genes in the PI3K/AKT/mTOR pathway result in PHTS-like disease. In order to identify the missing heritability in PHTS I aim to develop a long-read sequencing (LRS) approach for PHTS-like patients, which will go beyond the currently state-of-the-art short-read sequencing approaches. I will O1) develop a PTEN-targeted LRS assay and O2) perform this assay on a highly selective cohort of PHTS-like families (n=94). I then will O3) perform whole genome LRS on 25 families that were not solved by targeted LRS to identify novel gene-disease associations. At last, I will O4) validate these new associations in a wider cohort.Via this work, I will improve the diagnostic yield for PHTS by identifying novel genetic mechanisms and genes underlying disease in PHTS-like patients. The unique interdisciplinary structure of the Department of Human Genetics at Radboudumc will allow to rapidly implement genetic testing for the newly identified genetic causes for PHTS. Identification of the precise underlying cause of PHTS will enable cascade genetic testing of at-risk family members to determine their status for the causal variant and thus, risk of disease to them and any future off-spring. Furthermore, this approach will allow the implementation of preventive care strategies for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Waste as Valuable Elements for Europe' in the context of a Horizon Europe call.

assistant: **Objectives**

WAVEE, Waste As Valuable Elements for Europe, aims at valorise skills and know-how coming from academic and industrial scientists operating in the field of waste treatment and material science by the development of cutting-edge and low impact recovery methods for critical raw materials, CRMs from spent Li-ion batteries. The adoption of microwave radiation and mechanochemical approaches, in combination with mild organic/metal-organic compounds to replace conventional pyrometallurgy and strong and hazardous acids will provide a leap forward safer and greener recovery. The developed protocols will be scaled-up to pre-industrial level, to assess the overall efficiency of the innovative recycling processes and the quality of recovered RMs. Lastly, recovered materials will be tested in brand-new devices, such as batteries, catalysts, sensors and nanoelectronics. The outcomes of the project WAVE are relevant in key sectors for EU economy and for EU citizens, tackling the challenge of sourcing rare elements and properly dealing with waste valorisation and circular economy. This will result in improved efficiency and sustainability of the whole industrial chain of battery recycling, while ensuring a solid and reliable source of key RMs within EU. WAVEE Action pursue its main objectives through an intersectoral secondment plan, training activities, workshops and seminars for academic, SME and public audience. The consortium created for the project WAVEE represents a solid combination of internationally-recognised academic organisations possessing a wide experience on protocols related to the synthesis and treatment of materials for energy applications and advanced characterizations that is benchmarked by track record in both research publications and implemented projects.


**Key
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Efficiency of Futures Markets' to be submitted under Seventh Framework.

assistant: **Abstract**

The project is a cooperation between Ghent University, Belgium, Queen's University Belfast , UK, and the SME Risk & Portfolio Management AB, Stockholm, Sweden.It makes use of a unique, private data set provided by the SME involved. The data is on transactions of futures traders, so-called CTAs. These are often referred to as hedge funds, although the institutional setup and trading mechanisms show substantial differences to these. We will analyze the efficiency of the futures markets (including equity, bond, commodities, and currencies. The data allows to track decisions by individual managers or particular groups of managers. We can therefore on a daily basis observe actions CTAs take.Objectives of the project are:(i) to utilize this outstanding data set for academic research, aiming at publications in top-journals(ii) to give the SME access to the most recent academic achievemnets.(iii) to strengthen the SME's profile as a research-oriented and quantitative corporation(iv) to make academic staff familiar with the practice of asset management and(v) to establish a long-term cooperation between the partners.We will achieve this by(i) joint research(ii) a high number of intersectoral secondments in both directions(iii) teaching at the other sector's instittution(s)(iv) a doctroral, education for an SME staff member(v) the recruitment of two experienced researchers to the SME(vi) scientific conferencesAs a result - and since all results will be made available to third parties - the project will help to root decisions by the financial sector in science and will on the other hand help to make academic research practically relevant. Furthermore, the position of the European financial sector and European universities will be strenghtened.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support for EU-China cooperation in the ICT field' in the context of a Sixth Framework call.

assistant: **Objectives**

The Chinese information technology market is, worldwide, the one that presents the greatest prospects in the short, medium and long term. It is therefore essential that European organisations quickly develop scientific and technical cooperation projects with Chinese organisations in order to be able to take advantage of the expected dynamism of the Chinese markets.It is also necessary that the cooperation efforts of European organisations are supported by actions to facilitate their emergence, accompany their development and strengthen their impact. Over the period 2005-2008, the CHINACOOP Project will provide such support, in continuity with the support actions that the IST Programme has been developing European organisations for almost 5 years. These were in particular expressed through the organisation of the EuroChina2002" event in April 2002 in Beijing and the setting up of the "EU-China Working Group on Digital Olympics".More precisely, the CHINACOOP Project will:- continue providing DG Infso with operational support in organising periodic meetings with the Chinese authorities, in particular with the Chinese Ministry of Science and Technology, MOST.- prepare and organise an IST exhibition in Beijing during the 2008 Olympic Games to showcase European know-how in the field of Digital Olympics and ICT in general.- maintain the information and support services for European organisations offered by the www.EuroChina-IT.org portal dedicated to cooperation between the European Union and China in the ICT field.CHINACOOP is expected to have a major impact on the quality of the political cooperation framework between the EU and China in the ICT field, on the intensity of S&T cooperation activities between the EU and China, and on the image of European organisations and of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'European Union Microdose AMS Partnership Programme' (EUMAPP) targeting Sixth Framework.

assistant: **Abstract**

The concept of human microdosing with a view to obtaining critical pharmacokinetic (PK) information to assist in the development of new drugs is a relatively new approach. As the pharmaceutical industry is a relatively conservative one, the potential value of this technology has been recognised by many but taken on board by few. It is therefore imperative that a body of knowledge is built to convince the pharmaceutical industry of the merits of human microdosing as a science driven approach to drug development. Standardised, well defined, ultra-sensitive and easy to use technologies for enabling human microdosing are required to facilitate the adoption of the microdosing concept and hence accelerate the drug development process. The European Union Microdose AMS Partnership Programme (EUMAPP) project gathers together 10 organisations from 5 countries (United Kingdom, Sweden, Netherlands, France and Poland) towards the certification of high and low voltage ultra-sensitive Accelerator Mass Spectrometry (AMS) technologies as the most accurate, reproducible and appropriate analytical methodologies for all measurements required by microdosing studies. Microdosing approach conducted with AMS offers new ways of developing drugs that allow bridging the present gap between the laboratory and the clinic. The EUMAPP project will contribute to putting Europe at the forefront of microdosing by i) demonstrating the microdosing approach reliabilityfor predicting drugs PK when used at pharmacological doses (from 7 different biopharmaceuticals), ii) certifying AMS as the most accurate, appropriate and powerful technology for reproducible measurements required by microdosing studies, and finally iii) developing in silico modelling application to predict PK parameters from data derived fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Synaptic resilience in Tau-induced neurodegeneration' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Dementia is an enormous burden on society. Patients require life-long care and there is no cure or symptomatic treatment. At early phases, dementia is closely associated with synaptic degeneration and this correlates well with Tau pathology in >20 Tauopathies. Interestingly, historic observations in hamsters and squirrels show that when they enter into hibernation, they also display Tau pathology and synaptic loss. Pathologists have pointed to these similarities; however, there is an important difference: synaptic loss is progressive in dementia, but reversible in hibernating animals. Capitalizing on recent technological advancements, I will unravel the mechanisms of this remarkable, yet understudied process of synaptic remodeling in hibernation and then use the pathways that reverse synapse loss in hamsters, to counteract Tau-induced synaptic decline in models of dementia. We will achieve these goals by first defining and studying the molecular and cellular drivers of synaptic remodeling during cycles of hibernation. This is based on innovative spatial transcriptomic and synaptic proteome analyses in hamster brains. We will then identify the human homologues of the hamster genes that reverse synaptic loss following hibernation and use a selection strategy in xenotransplanted human neurons and functional assays on custom-designed multielectrode arrays, to isolate genes rescuing Tau-induced neurodegeneration. This approach is bold, but feasible; my lab has a record of accomplishment in synaptic and neurodegeneration research and we already have strong preliminary work implicating specific pre-synaptic pathways in the types of Tau-dependent synaptic remodeling that we will study here. The gain is that we will uncover the mechanisms of a remarkable process of synaptic resi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Breaking waves and air-sea gas transfer' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Experimental and theoretical approaches will be integrated to better understand the complicated processes that influence air-sea gas transfer and to develop algorithms for practical use. To derive better parametrisation of the air-sea transfer velocities of gases in terms of environmental parameters that are routinely available. To improve knowledge of the effect of shear on breaking waves, and how breaking waves and shear combine in air-sea transfer. To develop practical methods of measuring bubble fluxes and distributions which can be applied both on the open ocean and in the laboratory. To improve the parametrisation of the relationship of bulk sea surface temperature and radiometric brightness temperature.Measurements will be made in September 1996 and in February/March 1997 in the Large Air Sea Interaction Simulation Tunnel of the Institut de Recherche sur les Phenomenes Hors Equilibre, Laboratoire Interactions Ocean-Atmosphere Luminy (IRPHE-IOA), in Marseille, France.The tunnel will be sealed and tests will be made to determine the exchange of air between the tunnel and its surroundings. Air introduced in the tunnel will be purified.Whitecaps will be simulated with bubbles generated by an aeration device (a submerged grid of porous ceramic tubes)and by waves generated by wind and/or a wave maker. Bubble spectra and fluxes will be quantified optically and acoustically. Surface phenomena and micro-layer structure will be studied with thermal imagers and radiometers.Breaking wave phenomena and turbulence in water and air will be quantified. Gases will be introduced into the tunnel, either in the water or in the artificially generated bubbles, and gas concentrations will be measured in the water and in the air to determine the exchange rates in a variety of conditions