RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Paediatric european network for treatment aids', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The primary aim of PENTA is to evaluate new antiretroviral and immune therapies in children, and particularly to develop trials addressing important management issues, which cannot be assumed from results of trials in adults. Has established a network of paediatric centres and collaborating laboratories from 11 European countries to undertakemulticentre clinical trials. With the prolongation of disease-free life associated with potent antiretroviral therapy(ART), new therapies are evaluated in adult trials using endpoints of viral load reduction and immune response. However, there are important differences between adults and children in these parameters. Pharmacokinetic studies are essential as some drugs such as the protease inhibitors are metabolised faster in children and extrapolating from adult data would result in under dosing which could increase the risk of developing resistance to HIV. Increased collaboration with other international groups running studies in HIV infected children is planned for new trials and for undertaking meta-analyses. Collaboration and communication between clinical centres will be increased through pentad newsletter, training exchanges and the development of a PENTA website.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Simulating Brains: Cognition Grounded in the Simulation of Sensorimotor Processes in the Human Neocortex' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Grounded (embodied) cognition theory proposes that cognition is grounded in processing of sensorimotor information. The main proposal for how this information grounds cognition is mental simulation. This process has been suggested to depend primarily on hierarchically-organized, convergence-divergence zones in association cortex. However, no direct neural tests of mental simulation or this mechanism have been done. This project will test crucial timing predictions. By this account, processing proceeds sequentially from unimodal areas in one modality through multimodal association areas and then out to other unimodal areas. To test this, the project aims to determine how and when processing sensorimotor features in the human brain affects the cortical dynamics as they unfold over time for visual object cognition. The researcher’s multi-state interactive account of the cortical dynamics for visual object cognition predicts the timing and location of effects. Such precise predictions allow the most powerful conclusions from neuroscience data. High-density, event-related potentials have the time precision needed. Functional magnetic resonance imaging, which has higher spatial precision, helps localize effects. Transcranial magnetic stimulation disrupts perceptual or motor processing briefly to test the causal role. To integrate human and non-linguistic animal data in future computational models, studies focus on objects (i.e., not words) in the visual modality that dominates in humans. This project will for the first time reveal how, when, and how much processing modal features (color, motion, shape, size, orientation, and actions) affects the temporal dynamics of cortical processes supporting visual object cognition and the causal role of such sensorimotor processing. Such
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SMARTSENS: Smart wear for sensing the neuromusculoskeletal system during human movement in vivo' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Neurological injuries such as stroke or spinal cord injury, leave 5 million people disabled worldwide annually, drastically impairing individuals' ability to move independently. The main element hampering efficacy of current neuro-rehabilitation procedures is the inability of sensing the activity of neural cells involved in the control of movement, along with the movement-generating mechanical force produced by innervated muscle-tendon units, in the intact moving human in vivo. Current technologies for sensing the neuromusculoskeletal system rely on expensive, large, and bulky sensing devices that can only be used in the highly controlled settings of research laboratories. Therefore, a wearable, rapid-to-wear system that could track function in a persons motor neuron activity along with associated function in muscle, tendon and joint function would revolutionise current neuro-rehabilitation paradigms. SMARTSENS proposes a fully wearable, non-invasive solution to monitor a range of clinically relevant neuromuscular parameters, which currently could only be extracted in constrained laboratory settings via lengthy procedures. SMARTSENS enables measuring such information during daily life activities using a sensorised smart wear that is unobstructive and rapid to wear. This will enable continuous monitoring of the human neuromusculoskeletal system, which will disrupt current movement-measuring and diagnostic systems, by enabling causal understanding of the activity of neural and musculoskeletal structures in vivo at a resolution not considered before.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Longitudinal analysis to study neurodegenerative diseases mechanisms in specific neuronal subtypes', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) are the most common human neurodegenerative diseases. Each features an abnormal accumulation of proteins, but whether the aggregation leads to neuronal death is controversial. HD is caused by a single mutation that increases the number of CAG repeats. Mutant huntingtin (htt) forms intraneuronal inclusion bodies (IBs). To determine if IBs are pathogenic, incidental, or a beneficial coping response, we developed an automated microscope system that enabled us to follow individual neurons over long periods of time. We prospectively measured the survival time of individual neurons and simultaneously monitored features, such as htt expression levels and IB formation. Using survival analysis methods, we sought to identify the best predictor of neuronal death. We found that the amount of diffuse mutant htt predicted death and that IB formation decreased the risk of neuronal death. Thus, IB formation may be a coping response against the more toxic diffuse mutant htt forms. Another common pathological hallmark of neurodegenerative disorders is a strong specificity for the affected neuronal populations. Paradoxically, the proteins affected in these diseases are ubiquitously expressed and yet only specific subsets of neurons are affected. Interestingly, areas less affected in HD brain patients show more IBs. Because aggregation and neuronal specificity are hallmarks of neurodegenerative diseases, we hypothesize that the different capacities of neuronal subtypes for handling mutant proteins (i.e., efficient aggregation or/and activating degradation pathways) explain differences in survival among neuronal types. We will express proteins affected in htt variants or PD (mutant versions of LRRK2) in differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Regional Storm, wave and surge scenarios for the 2100 century' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Objectives : To use numerical models to study storms, surges and waves, in the European/Northeast Atlantic region under present climate conditions and in a climate influenced by increase CO2-concentrations. Brief Description of the Research Project : The focus will be on improved statistical description of changes and understanding of key physical mechanisms. The project is a joint effort of meteorologists and oceanographers. The backbone of the project is two 20 year GCM-runs with the ECHAM-4 model at T-106 horizontal resolution, corresponding to 'present day' and 'equivalent CO2-doubling' conditions, respectively. For the atmospheric part of the project, the T-106 runs will be analysed with respect to severe storms in the North Atlantic. Furthermore, extreme cases will be studied in detail with the HIRHAM regional climate model. The effect of water vapour on baroclinic development will be studied. Also polar lows in the Norwegian Sea and convective systems in the Mediterranean will be studied using regional climate models (HIRHAM for polar lows and BOLAM for Mediterranean systems), based on selection criteria from the T-106 runs. For the oceanographic part, surge models will be run for the North-western European shelf area, with the atmospheric forcing from the T-106 runs and surge statistics will be derived. The dependency of storm statistics on the horizontal resolution of the surge model will be studied. A dynamical/statistical downscaling method will be developed to calculate surge statistics in estuaries. Also case studies of surges in the Mediterranean Sea will be performed. Ocean waves will be studied by running wave models forced by the T-106 runs covering the Mediterranean as well as the Northern Seas. Furthermore, an 'ocean wave generator' will be developed
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Large-area Organic and Hybrid Solar Cells' under Seventh Framework.

assistant: **Concept**

The task of developing large-area, thin film solar cells based on polymers as well as solid-state organic-inorganic (hybrid) systems will be undertaken. The required novel materials (charge transport polymers, semiconductor surfactants/compatibilizers and inorganic nanoparticles) will be synthesized and the compounds with the most potential will be scaled-up for the purpose of modern fabrication methods such as roll-to roll (R2R) processing. Additionally, the efficient devices will be tested and analyzed in out-door conditions in India and under accelerated ageing conditions in Israel to understand the degradation mechanism. Finally the basic information from stability studies will be used to design novel materials suitable for highly efficient devices of long-term stability. The programme is intensively intertwined with an Indian consortium, especially in the fields of novel materials, out-door testing, transfer and exchange of knowledge and methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Mineral-fluid Interface Reactivity' in the context of a Sixth Framework call.

assistant: **Objectives**

The Mineral-fluid Interface Reactivity (MIR) Early Stage Training Network (EST) is comprised of 5 universities located in Germany, France, Spain, Denmark, and the United Kingdom offering structured training for students pursuing a PhD or Masters Degrees. This training program is intended to produce young scientists to fill needs in industry, consulting engineering firms, regulatory agencies, and local government in addition academic positions.The core objective of the MIR network is the training and professional development of young scientists in the state-of-the-art in the field of mineral-fluid reactivity. Mineral-fluid reactions, including dissolution, adsorption, nucleation, precipitation, and solid-solution formation are key to solving such pressing issues as development of smart coatings on body implants or drug delivery systems, minimizing risk in groundwater extraction, safer pesticide application, optimising CO2 sequestration, assuring drinking water quality, safe storage of radioactive waste products, and minimizing pollutant transport.The ability to accurately predict reactions in these systems is of utmost importance for municipalities and for industry in Europe today, but it relies on a detailed description of mineral-fluid reactions. Because of the cost of acquiring and maintaining the facilities and the time required to become an expert, only a few of these expertises are available in any single laboratory or any single European country. The MIR network has been created to overcome the limitations by combining forces from University research centres from several countries. This multi-site, international network will provide the cross-disciplinary training that will produce scientists ready to advance the limits of knowledge for true innovative breakthroug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Enabling Technologies for Personal Air Transport Systems' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Considering the prevailing congestion problems with ground-based transportation and the anticipated growth of traffic in the coming decades, a major challenge is to find solutions that combine the best of ground-based and air-based transportation. The optimal solution would consist in creating a personal air transport system (PATS) that can overcome the problems associated with all of our current methods of transportation.We propose an integrated approach to enable the first viable PATS based on Personal Aerial Vehicles (PAVs) envisioned for travelling between homes and working places, and for flying at low altitude in urban environments. Such PAVs should be fully or partially autonomous without requiring ground-based air traffic control. Furthermore, they should operate outside controlled airspace while current air traffic remains unchanged, and should later easily be integrated into the next generation of controlled airspace.The myCopter project aims to pave the way for PAVs to be used by the general public within the context of such a transport system. Our consortium consists of experts on socio-technological evaluation to assess the impact of the envisioned PATS on society, and of partners that can make the technology advancements necessary for a viable PATS. To this end, test models of handling dynamics for potential PAVs will be designed and implemented on unmanned aerial vehicles, motion simulators, and a manned helicopter. In addition, an investigation into the human capability of flying a PAV will be conducted, resulting in a user-centred design of a suitable human-machine interface (HMI). Furthermore, the project will introduce new automation technologies for obstacle avoidance, path planning and formation flying, which also have excellent potential for other
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Ultra-Fast Brillouin Light-Sheet Microscopy for Real-Time Mechanical Imaging in Biology'.

assistant: **Objectives**

Understanding the mechanical properties of biological systems is crucial for unraveling key processes in development, disease progression, and cellular function. This ERC Proof-of-Concept project proposes the development of a next-generation Brillouin microscope, inspired by light-sheet microscopy principles, to enable ultra-fast, high-resolution, and label-free imaging of mechanical properties in live biological samples. Traditional Brillouin microscopy has been limited by slow acquisition speeds and photodamage, hindering its practical application in dynamic biological contexts. Our novel system integrates planar illumination and highly multiplexed spectral detection to dramatically increase imaging speed while minimizing phototoxicity and preserving mechanical contrast. This platform will empower researchers to study biomechanical dynamics in real-time, from embryonic development to cancer progression, with unprecedented temporal and spatial resolution. The project will also explore commercialization pathways, with potential applications in biomedical research, drug screening, and diagnostic tools. By demonstrating technical feasibility, validating biological relevance, and assessing market potential, this project bridges the gap between fundamental photonics research and impactful biomedical innovation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Photonics for Healthcare: multiscAle cancer diagnosiS and Therapy'.

assistant: **Concept**

The European Training Network PHAST (Photonics for Healthcare: multiscAle cancer diagnosiS and Therapy) provides excellent, highly-skilled education and training in the vibrant field of Biophotonics for 15 Early Stage Researchers (ESRs) in a strong multidisciplinary PhD programme. PHAST addresses some relevant “unmet needs” of the medical community in prevention, diagnosis and treatment of cancer – one of the leading causes of death worldwide – to significantly improve the quality of life for European society. The main scientific goal of PHAST is to develop multiscale advanced photonic technologies for the diagnosis of cancer in vitro and in vivo and the monitoring of therapy for personalized medicine, through its four specific objectives: 1. In-vitro diagnosis as point-of-care approach through optical spectroscopy combined with innovative sampling techniques. 2. Tissue diagnostics and functional monitoring by optical fibre-based biopsy and diffuse optical spectroscopy. 3. Microscale cancer monitoring by multimodal optical imaging of tumour borders during surgery. 4. Macroscale therapy monitoring by diffuse optical spectroscopy, multifunctional optical fibre sensors, autofluorescence, and hyperspectral imaging. The multi-scale level approach employed by PHAST will allow early cancer detection from molecular disease markers in body-liquids up to live organs. In specific cases these techniques will be validated in the clinic thanks to close collaboration with medical institutions. The ESRs will be trained to all the technologies through hands-on laboratory platforms, thematic workshops and courses to build solid careers as biophotonics professionals in both academic and non-academic sectors. This will be possible thanks to the multidisciplinary environment created by the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Reactive lost foam coating'.

assistant: **Concept**

The Lost Foam Casting is a quite new casting technology, which provides many different technical, economical and environmental advantages. However, in casting of aluminium alloys, this process makes a lot of problems, and rejection rates of up to 20 % are usual. Thus, although the technique has some advantages, its present market share is unsatisfactory compared to other casting technologies. Most of the problems are due to insufficient properties of the Lost Foam Coating, which is put onto the plastic pattern in the liquid state and after drying insulates the molten metal from the form sand. The key properties of such a coating are a definite permeability for the molten and gaseous decomposition products of the foam and at the same time a high mechanical stability. Additionally other properties, which can enable easy handling prior to casting, and easy and complete removal after casting, are essentially. The necessary properties are difficult to be achieved with conventional coatings for the conditions of aluminium casting. In this project a new type of Lost Foam Coating for casting of aluminium alloys will be developed and tested. The new approach to the chemical composition of the coating consists in adding reactive components, which can provide a chemical reaction at the casting temperature or below and form a porous ceramic layer with the desired superior properties. To do these developments, a consortium of industrial suppliers and producers of coatings and of casting factories for testing the products as end users has been established (SME), while the scientific work necessary is done by RTD performers. It is expected, that by the use of the new coating the rejection rate of the process can be reduced from 20 % to 1 %, so that in perspective the market share of l