RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Unveiling the role of Ecological Interactions in Antibiotic Resistance Evolution via Horizontal Gene Transfer' (2021-2027).

assistant: **Innovation**

Horizontal Gene Transfer (HGT) stands among the most common mechanisms for the emergence and persistence of Antibiotic Resistance (AR) in microbial communities, a major challenge in medicine and agriculture. While molecular mechanisms driving HGT are typically studied through in vitro co-cultures of two species, a donor and an acceptor species, HGT occurs in nature within microbial communities (such as the human gut microbiome) in which such two species interact with many others. Metagenomics has identified these ecological interactions as potential catalysts for HGT, yet direct experimental evidence remains lacking.This project aims to elucidate how ecological interactions drive HGT of AR genes in diverse bacterial communities by combining experiments and theoretical models. Recent experimental advances have enabled the ecological interrogation of highly diverse communities in vitro, while theoretical models, inspired by statistical physics, can disentangle the dominant ecological interactions and predict the community dynamics. I will use high-throughput, in vitro techniques to assemble hundreds of different synthetic communities in which we will measure the rates of HGT of AR genes, both in the presence and absence of antibiotic exposure. I will develop a novel theoretical model that incorporates species interactions, environmental context and HGT. Utilizing statistical physics tools, I will generate testable predictions capable of interpreting the experimental outcomes. The project aims to generate a novel, quantitative understanding of how ecology modulates the HGT of AR genes, bridging the gap between molecular mechanisms previously described in pairwise co-cultures and ecological trends inferred from metagenomics. This knowledge will not only lead to the developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Microbiome Assembly and Transfer under Ecological- and Sexual Selection' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Bacteria, like animals, rely on transmission to spread and colonise new environments. In this context, the microbial communities that inhabit and/or transiently interact with animal hosts, collectively known as the “microbiome”, are key to animal health and fitness. The assembly of the microbiome in the hosts begins at birth and later undergoes a variety of dynamic processes influencing its establishment, function and evolution. Newly, research has theoretically recognized the importance of the microbiome associated with reproductive organs and fluids in influencing a range of reproductive processes and outcomes in males and females. The study of such communities founding the ""reproductive microbiome"" and the ease with which they could be tracked between hosts’ reproductive systems therefore offers key advantages for measuring the role of host-mediated transmission in microbiome assembly and variation. Still, we lack an understanding of the ecological mechanisms influencing such variation. Advances in meta ’omics are sparking interest in how microbiomes impacts physiology, propensity to disease and in turn natural and sexual selection. In addition, gnotobiotic organisms provide unique opportunities to study host-microbiota interplay with a level of experimental control that is not achievable in human studies. Coupling these two approaches should allow to pinpoint key mechanisms underlying this mutualistic relationship in a research field that is still in its infancy. In this light, we will make use of accurate observational systems that have been established to monitor interactions and mating events in the internally fertilising fish Poecilia reticulata, to measure the contribution of host contact to reproductive microbiome transmission and assembly, and how how this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Bayesian Statistics in Infinite Dimensions: TargetingPriors by Mathematical Analysis'.

assistant: **Concept**

I propose novel methods for understanding key aspects that are essentialto the future of Bayesian inference for high- or infinite-dimensionalmodels and data.  By combining my expertise on empirical processes andlikelihood theory with my recent work on posterior contraction I shallforemost lay a mathematical foundation for the Bayesian solution touncertainty quantification in high dimensions.Decades of doubt that Bayesian methods can work for high-dimensionalmodels or data have in the last decade been replaced by a belief thatthese methods are actually especially appropriate in thissetting. They are thought to possess greater capacity forincorporating prior knowledge and to be better able to combine datafrom related measurements. My premise is that for high- orinfinite-dimensional models and data this belief is not well founded,and needs to be challenged and shaped by mathematical analysis.My central focus is the accuracy of the posterior distribution asquantification of uncertainty. This is unclear and has hardly beenstudied, notwithstanding that it is at the core of the Bayesianmethod. In fact the scarce available evidence on Bayesian crediblesets in high dimensions (sets of prescribed posterior probability)casts doubt on their ability to capture a given truth. I shall discoverhow this depends strongly on the prior distribution, empirical orhierarchical Bayesian tuning, and posterior marginalizaton, and therewithgenerate guidelines for good practice.I shall study these issues in novel statistical settings (sparsity andlarge scale inference, inverse problems, state space models,hierarchical modelling), and connect to the most recent, excitingdevelopments in general statistics.I work against a background of data-analysis in genetics, genomics,finance, and imaging, and em
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Silicon cycling in the world ocean: the controls for opal preservation in the sediment as derived from observations and modelling' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The main objectives of the project are:I) To provide a data base of observations and a general circulation model which allow comprehensive studies of the silicon cycling in the oceans;II) To reproduce the first principles of silicon cycling in today's world ocean by use of an ocean general circulation model;III) To offer an explanation for the present opaline sedimentary distribution;IV) To test our improved understanding of opal by a paleoceanographic application of the model and compare the simulations with the observed sediment record.In order to enable full use of the paleoclimatic information of the opal sediment record we propose as scientifically innovative steps to: - gather all existing observed Si and opal data for the present ocean including flux rates and summarize them in a combined data set which allows systematic statistical and analytical evaluation (task 1- data base), - present a first coupled three-dimensional ocean-sediment model including opal and early diagenesis processes on the basis of an ocean general circulation model velocity field which allows realistic regional resolution of large scale oceanic tracer fields (task 2 - model reference run), - use both tools to systematically diagnose model deficiencies (task 3 - comparison) and try to remove disagreements between model and observations for the present ocean by development of new parametrisations for marine Si cycling, in particular for opal dissolution under various conditions (task 4- optimisation), - apply the optimal model version to ocean velocity fields which represent the Last Glacial Maximum and the mid-Miocene (open/closed Central America isthmus) (task 5 - validation).The project is based on a close collaboration of experimental and modelling scientists. It will provide the scientif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Hybrid organic/inorganic memory elements for integration of electronic and photonic circuitry'.

assistant: **Innovation**

The objectives of the project ""Hybrid organic/inorganic memory elements for integration of electronic and photonic circuitry"" (HYMEC) are to resolve fundamental issues of materials science and to realize new hybrid inorganic/organic devices with functionality far beyond current state-of-the-art. This is of direct relevance to the objectives of the FP7-NMP Work Programme, as it calls for ""design novel knowledge-based smart materials with tailored properties, releasing their potential for enhanced and innovative applications"". Specifically, we will perform research towards understanding and controlling all relevant properties of systems comprising inorganic metal nanoparticles embedded in matrices of conjugated organic materials (organic semiconductors), and we will demonstrate the function of such material hybrids as non-volatile memory elements that can be addressed electrically and optically, which thus represent potential interconnects of future hybrid electronic and photonic circuitry. Moreover, we target implementing cost-efficient production routes, such as printing, as well as exploring the ultimate miniaturization of such memory elements by novel sublimation- and imprinting-based nanostructuring processes.Electronic, optical, dielectric, structural, and morphological properties of our systems will be determined using state-of-the-art experimental techniques and modelling to establish a reliable specific knowledge base, which we will exploit for device fabrication and integration. Through our cooperative efforts, we expect to make use of new knowledge for the realization of reliable non-volatile memory elements (NV-ME) employing resistance switching, with a substantial extension of existing NV-ME functionality, i.e., optical addressing of devices in addition t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Home or hospital in heart failure' (HHH) targeting Fifth Framework.

assistant: **Abstract**

Home monitoring of cardiovascular and other parameters is being tested in heart failure (HF), since HF is an increasing load on scarce hospital resources. Previous monitoring recorded weight, heart rate and blood pressure compared to telephone contacts.Novel features of this application extend this approach by:a) long-term monitoring of respiration and heart rate rhythm and variability, as irregular breathing, arrhythmias and sympathetic hyperactivity have powerful effects on morbidity and prognosis,b) new user-friendly systems to collect such data at home andc) new methods of data transmission and analysis.These new features will be compared with existing state of the art techniques and more simple management algorithms. Prognostic prediction, patient QOL, education and self-care, and cost-effectiveness in different European countries will be assessed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Orchestrating an interoperable sovereign federated Multi-vector Energy data space built on open standards and ready for GAia-X' (OMEGA-X) targeting Horizon Europe.

assistant: **Abstract**

Orchestrating an interoperable sovereign federated Multi-vector Energy data space built on open standards and ready for GAia-XThe aim of OMEGA-X is to implement a data space (based on European common standards), including federated infrastructure, data marketplace and service marketplace, involving data sharing between different stakeholders and demonstrating its value for real and concrete Energy use cases and needs, while guaranteeing scalability and interoperability with other data space initiatives, not just for energy but also cross-sector.The proposed concept and architecture heavily rely on the approaches adopted by IDSA, GAIA-X, FIWARE, BDVA/DAIRO and SGAM as major EU references regarding data spaces. It will pursue the GAIA-X label, which ensures highest standards on protection, security, transparency, openess and trust, avoids vendor lock-in and restricted to EU countries.•Federated infrastructure for data ingestion. There are a lot of independent platforms for data ingestion/storage, open and private. The goal is to define the minimum interoperability and federation requirements needed for these platforms to adhere to the Energy Data Space and be able to share data in a trusted and secure way.•Data Space Marketplaces. This is the common ground where data, which is already harmonized semantically, is indexed, and referenced, maintaining always the required standards of identity, trust and sovereignty. Using the data space as baseline, a marketplace is implemented for stakeholders to share, use and monetize data and services. Data/service providers will be able to advertise their data/services, and data/service users will be able to discover multiple data sets and services.•Advanced Energy Use Case demonstration. Using all aforementioned layers underneath, 4 us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Low cost assembly of jewellery by diffusion soldering' (1998-2002).

assistant: **Concept**

Diffusion sodering has been identified as a new joining process that can help the European jewellery industry to reduce costs by decreasing finishing operation and increase the productivity. The process combines the features of liquid-phase joining (i.e. soldering) and diffusion bonding and has the beneficial features of both techniques. The implementation of this new manufacturing method for gold jewellery will represent technology transfer from high-tech electronic industry to a more traditional, workshop-type activity. In the electronics industry the bonding involves pure metal platings namely of silver and gold whereas in jewellery bulk precious metal alloys need to be bonded. This process does not require corrosive chemical j-fluxes and branzing torches which are used in existing gold jewellery fabrication by brans-zing. Thereby, its use will help to improve the working environment in the jewellery industry and will lead to a market reduction in polluting effluent. Manufacturing yields should also improve by replacing individual operator skills by oven operations. The net prospective cost savings to the European jewellery industry will be about 200 million euro. This process change should help stem the industry's decline through aggressive competition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Investigating DC migration with large, ingested cargos through confining environments'.

assistant: **Concept**

As immune sentinels, dendritic cells (DCs) must be able to ingest material and migrate to lymph nodes to present the processed antigen to T cells, and initiate the adaptive immune response, essential against pathogens or cancer. This means that DCs must be able to navigate through complex environments with this ingested material of varying physical characteristics. Preliminary data revealed that DCs deform and/or rotate large, ingested material to overcome occlusion from entering constriction points (transmigration). Additionally, there are instances of nuclear deformation and even migratory frustration, which reflect reported phenomena of DCs in vivo in mice. I propose to use a suite of fabricated particles and in vitro complex environments to test the ability of mouse bone marrow-derived dendritic cells to overcome physical obstacles with large cargos. The fabricated particles will include oil droplets with tunable deformability, paramagnetic particles, and 3D printed microplastics. The in vitro complex environments are collagen gels and PDMS microchannels where I can observe DCs with ingest particles attempting to through points of constriction. With this experimental set-up, I can measure the efficiency of transmigration, deformation or rotation of particles, as well as the force exerted on particles as a function of particle properties. Furthermore, I can observe the effect of particle manipulation on DC behavior and function, even if they never successfully transmigrate. This work will aim to answer how dendritic cells can migrate successfully with a wide range of materials, but also provide insight into the role of frustrated or trapped DCs that are observed in tissues, and particularly near tumors.


**Keywords:** dendritic cells,  transmigration,  cargo manipul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Youth-centred Preventive Action Approach towards co-created implementation of socially and Physically activating Environmental interventions' in the context of a Horizon Europe call.

assistant: **Objectives**

BACKGROUND: A vast majority of teenagers do not meet guidelines for healthy movement behaviours (i.e. physical activity, sedentary behaviour and sleep), posing major risks for developing multiple non-communicable diseases (NCDs). Sustainable implementation of lifestyle interventions focused on teenagers is a key challenge.AIM: YoPAAPE aims to tailor, implement and evaluate social and physical environmental interventions for structural improvement in the lifestyle of teenagers (12-18 years) in vulnerable life situations to reduce their NCD risk.APPROACH: YoPAAPE introduces teen-centred, evidence-informed co-creation to tackle the complex real-world challenge of unhealthy lifestyles and health inequalities. In urban environments in HICs (NL, DK) and LMICs (ZA, NG), we will engage teenagers and other key stakeholders in local co-creation communities. Together with academic researchers and local stakeholders, teenagers will take a leading role in 1) mapping the local system, including needs and opportunities; 2) tailoring interventions to the local context; 3) implementing, and 4) evaluating interventions guided by our novel SUPER-AIM framework assessing local Systems, User perspective, Participatory co-creation process, Reach, Effects, Adoption, Implementation, and Maintenance of interventions in an integrated manner. IMPACT: All results will be integrated in an open access YoPAAPE toolbox targeted at researchers, public health practitioners and authorities, policy makers, and citizens. By establishing an infrastructure for teen-centred co-creation including capacity building, mentoring, and participation of teenager health advocates, YoPAAPE will nurture sustainable implementation of teenager-responsive preventive interventions tailored to the local context, improving the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Urban Nature Labs'.

assistant: **Objectives**

UNaLab will develop, via co-creation with stakeholders and implementation of ‘living lab’ demonstration areas, a robust evidence base and European framework of innovative, replicable, and locally-attuned nature-based solutions to enhance the climate and water resilience of cities. UNaLab focuses on urban ecological water management, accompanied with greening measures and innovative and inclusive urban design. The UNaLab partners aim to develop smarter, more inclusive, more resilient and more sustainable local societies through nature based innovation jointly created with and for stakeholders and citizens. UNaLab’s 3 front runner cities: Tampere, Eindhoven and Genova, have a track record in smart and citizen driven solutions for sustainable development. They support 7 follower cities: Stavanger, Prague, Castellon, Cannes, Basaksehir, Hong Kong and Buenos Aires plus share experiences with observers as City of Guangzhou and the Brazilian network of Smart Cities. Therefore UNaLab results will impact on different urban socio-economic realities, with diversity in size, challenges and climate conditions. In order to create an EU reference demonstration and go-to-market environment for NBS, UNaLab will use and further develop the ENoLL Urban Living Lab model, and the European Awareness Scenario Workshop method for the co-creation of solutions, and the roadmap approach, in this way achieving an innovative NBS toolbox. Roadmaps will be used in all 10 cities, but in particular serve the follower cities. VTT, with a track record in the field of urban sustainability and Smart Cities, leads UNaLab. The UNaLab consortium is comprised of 29 partners across 12 different European countries and three non-EU countries. The consortium is well-balanced, representing key stakeholders within t