RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Robust Internal Thermal Insulation of Historic Buildings' (RIBuild) under Horizon 2020.

assistant: **Objectives**

RIBuild will strengthen the knowledge on how and under what conditions internal thermal insulation is to be implemented in historic buildings, without compromising their architectural and cultural values, with an acceptable safety level against deterioration and collapse of heavy external wall structures. The general objective of RIBuild is to develop effective, comprehensive decision guidelines to optimise the design and implementation of internal thermal insulation in historic buildings across the EU. RIBuild focuses on heavy external walls made of stone, brick and timber framing, as most historic buildings are made of these materials. The general objective is achieved through three main activities• To obtain a thorough knowledge level to characterise the eligibility of the building for a deep internal thermal insulation renovation. This knowledge is obtained through screening of historic buildings, investigation of material properties and threshold values for failure• To determine the conditions under which different internal insulation measures are reliable and affordable measures based on probabilistic modelling of the hygrothermal performance, the environmental impact and the cost/benefit• To develop a set of comprehensive decision guidelines  and a web-based assessment tool, which are demonstrated in a number of buildings. RIBuild addresses the most difficult retrofitting measure of historic buildings: internal thermal insulation. The adaption of knowledge developed by RIBuild contributes to sustainable historic buildings with improved energy efficiency implying an easier conversion of energy supply from inefficient fossil fuels to efficient renewable energy sources. RIBuild also assesses the hygrothermal performance of the building construction, thus no collater
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Characterisation of a new protein secretion pathway in pseudomonas aeruginosa' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

This proposal aims to characterise a novel protein secretion pathway in Pseudomonas aerations, which would mediate the secretion of folded proteins from the cytoplasm to the extra cellular medium that would be different from any other bacterial secretion system described so far.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of new technology for aluminium dross complete recovery' (Alucyc) targeting Seventh Framework.

assistant: **Abstract**

The aim of the Alucyc project is to develop a new process to recover metallic aluminium from aluminium dross. Comparing with available state-of-the art technologies, the yield of metallic aluminium will be increased from 95% to 99% using the new technology developed in Alucuc. Alucyc technology is waste-free, cryolite and the remaining aluminium oxcide could be used in melting of primary aluminium as additives.To develop the Alucyc technology, a phase model, novel electro slag furnace with non-consumable electrodes and process and power control systems will be designed and integrated. By consultations of primary aluminium smelters, Alucyc technology will interest potential end users in industry and will be therefore easily exploitable.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DevelopIng Genetic medicines for Severe Combined Immunodeficiency (SCID)' (SCID).

assistant: **Innovation**

Severe combined immunodeficiency (SCID) is a devastating rare disorder of immune system development. Affected infants are born without functional immune systems and die within the first year of life unless effective treatment is given. Treatment options are limited to allogeneic haematopoietic stem cell transplantation and autologous stem cell gene therapy. Over the last 15 years, gene therapy for two forms of SCID (SCID-X1 and ADA SCID) has shown significant safety and efficacy in correcting the immunodeficiency and allowing children to live normal lives. Proof of concept of gene therapy for 3 other SCID forms has also been shown by members of the proposed SCIDNET consortium and is ready for translation into clinical trials. We are therefore in a position whereby, over the next 4 years, we can offer gene therapy as a curative option for over 80% of all forms of SCID in Europe. Importantly for 1 of these conditions (ADA SCID) we will undertake clinical trials that will lead to marketing authorisation of the gene therapy product as a licensed medicine. In addition, we will investigate the future technologies that will improve the safety and efficacy of gene therapy for SCID.Our proposal addresses an unmet clinical need in SCID, which is classified as a rare disease according to EU criteria (EC regulation No. 141/2000). The proposal also addresses the need to develop an innovative treatment such as gene therapy from early clinical trials though to a licensed medicinal product through involvement with regulatory agencies and is in keeping with the ambitions of the IRDiRC. The lead ADA SCID programme has Orphan Drug Designation and clinical trial design is assisted by engagement with the European medicines Agency. The ADA SCID trial will act as a paradigm for the developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The Effect of DNA Topology on Eukaryotic Replication'.

assistant: **Concept**

The replication of DNA is one of the fundamental processes that drives all life. Errors in replication are responsible for a host of human diseases as well as for all adaptation and evolution, and hence the mechanisms, regulation, and fidelity of this process are of great interest to both fundamental biology and medical research. A complete, active replisome was recently reconstituted in yeast, allowing unprecedented probing and control of eukaryotic DNA replication in in vitro experiments. In this fellowship, I will take the exciting new opportunity offered by this breakthrough to study how torque and twist in the DNA double helix affect replisome activity. I will measure how DNA supercoiling affects replisome assembly and how the progressive buildup of torque impacts its progression along DNA. At the torque that fully stalls the replisome, I will determine its still-unknown composition. Finally, I will examine how such torque buildup impacts the disruption of nucleosomes present on the DNA to assess whether this effect can play a significant role in vivo. To achieve these scientific insights, I will both make use of the biological expertise and single-molecule instrumentation  that are available in the host laboratory (e.g. TIRF microscopy, magnetic tweezers), and use my expertise to develop and exploit an integrated instrument that facilitates evaluation of replisome composition on different DNA substrates.  These experiments will shed light on the functioning of the eukaryotic replisome, particularly its dynamic response to force and torque. The use of single-molecule techniques to study the full replisome is unprecedented, and the development of an integrated tweezers/TIRF instrument will be unparalleled in the depth of insight it can offer. In doing so, I will ans
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'TRENDS AND INDICATORS FOR MONITORING THE EU THEMATIC STRATEGY ON SUSTAINABLE DEVELOPMENT OF URBAN ENVIRONMENT'.

assistant: **Innovation**

Within the 6th Environment Action Programme, the Commission will develop a Thematic Strategy on the Urban Environment. The work will include the development of appropriate indicators and other monitoring tools to assess the effectiveness of the strategy. This task is taken as a premise for the project. TISSUE will evaluate whether the information that can be received with help of existing indicators will be adequate to monitor the Strategy or whether further indicators should be developed. In order to successfully fulfil the task, the project will co-operate with other ongoing actions; in particular the work of the Expert Group on the Urban Environment and their Thematic Working Groups. The overall goal of the project is deployed in specific objectives as follows:- analyse demand and define appropriate trends (in consultation with the Commission) which should be measured to properly determine progress towards sustainable development of the urban environment at local level;- carry out comparative research on existing sets of indicators to determine whether they:i) are able to provide the information needed to monitor developments at the different local levels on the trends identified in the first step;ii) can be used to assess trends at the EU level;iii) their implementation is viable;- define the set-up needed for a harmonised set of indicators and for effectively utilising the information from existing indicators and make recommendations for further research;analyse the conditions how to increase the acceptance of harmonised sets of indicators through Europe and motivate the cities to use them;- collect indicators and structure the indicators into a database. The indicators to be considered are urban environment indicators in use or being developed at EU level, nationa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Airborne Wind Energy System Modelling, Control and Optimisation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The height of conventional wind turbines is limited by the enormous stresses on the structure. The idea of the Airborne Wind Energy (AWE) is to replace the most efficient part of a conventional wind turbine, the tip of the turbine blade, with a fast flying high efficiency kite, and to replace the rest of the structure by a tether which anchors the kite to the ground. Power is generated either by periodically pulling a ground based generator via a winch, or by small wind turbines mounted on the kite that exploit its fast cross wind motion. While the concept is highly promising, major academic and industrial research is still needed to achieve the performance required for industrial deployment. This can best be done by innovative junior researchers in a closely cooperating consortium of academic and industrial partners.The ITN AWESCO combines six interdisciplinary academic and four industrial network partners with seven associated partners, all selected on the basis of excellence and complementarity. All partners work already intensively on AWE systems, several with prototypes, and they are committed to create synergies via the cooperation in AWESCO. The main task is to train fourteen Early Stage Researchers (ESRs) in training-by-research and to create a closely connected new generation of leading European scientists that are ready to push the frontiers of airborne wind energy.AWESCO is the first major cooperation effort of the most important European actors in the field and will help Europe to gain a leading role in a possibly huge emerging renewable energy market, and to meet its ambitious CO2 targets. In addition, the AWESCO early stage researchers will be trained in cutting-edge simulation, design, sensing, and control technologies that are needed in many branches of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Symplectic Geometry, Cotangent Bundles and Mechanical Systems' (SYGECOMES), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of this project is to advance significantly the understanding of the symplectic geometry of cotangent bundles endowed with lifted actions, from the point of view of reduction, mechanics and applications.The usual methods of symplectic geometry and symplectic reduction applied to cotangent bundles with Hamiltonian lifted symmetries are not fine enough to treat this important case since the extra bundle structure that makes a cotangent bundle different from other symplectic manifolds are not taken into account.Recently, adapted methods for the study of singular reduction of cotangent bundles at zero momentum have been introduced by the proposer, opening the field to a big amount of future original research. In this project this program is continuated, obtaining generalizations not only to arbitrary momentum values but also to other related geometries, like Poisson and contact geometry.This study will be done both globally and locally. Globally, the various classic results on regular cotangent bundle reduction will be generalized to the singular case within the framework of stratified spaces. Locally, invariant tubular neighbourhoods and normal forms for the momentum map adapted to the extra bundle structure will be found.The geometric results obtained will produce a core of applications, which are an important part of this project. These include new insights in the stability and bifurcations of relative equilibria in classical mechanical systems, the geometry of symmetric non-holonomic systems with singularities, and the interplay between the schemes of singular Poisson reduction of cotangent bundles and the classical theory of the geometry and representations of compact Lie groups, among others.Finally, this fellowship will provide the pro poser advanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Photocatalysis in Drug Discovery - Asymmetric Preparation of Bioactive Chiral Lactones and Cyclohexanols' (PHOTO-CYCLE) targeting Horizon 2020.

assistant: **Abstract**

We are in a changing era for drug discovery: the growing perception is that basic chemical research will play a greater role in pharmaceutical development. One current challenge is to develop a new kind of chemistry that yields a screening collection of optimal chiral molecules that increase the probability of success in identifying drug-candidate structures. PHOTO-CYCLE seeks to provide some solutions by developing effective technology to rapidly generate, in one single step, architecturally complex chiral natural-like compounds. Specifically, we will use photochemical organocatalytic cascade processes to synthesise polycyclic lactones and polyfunctionalized cyclohexanols, which are common motifs in biologically active molecules. We will combine asymmetric organocatalysis and photochemistry, two powerful strategies of modern chemical research. They have extraordinary potential for the sustainable preparation of novel organic molecules, which are needed to drive innovation in the pharmaceutical industry. PHOTO-CYCLE aims to combine the fellow’s experience in allene chemistry and organocatalysis and the host’s experience in photo-triggered asymmetric processes to develop otherwise unachievable catalytic asymmetric cascade reactions. Specifically, we will focus on the rich reactivity of excited chiral iminium ions to activate readily available allenes and trigger cascade processes. The resulting strategies will be used as an ideal platform for assembling libraries comprising chiral polycyclic lactones and cyclohexanols, which, along with biological screening carried out in collaboration with Lundbeck A/S, will increase the probability of success in identifying drug-candidate structures. The multi-cultural and intersectorial nature of this project will greatly contribute t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Pattern resilience'.

assistant: **Innovation**

The project will develop methods and prototype software tools for modeling and managing pattern resilience in complex systems. Pattern resilience is understood as the capacity of the system to maintain or to recover some desired pattern dynamics in a changing environment. The patterns statistical regularities which are generated by the interconnected components of the system. They evolve with time which justifies the term 'pattern dynamics'.We shall build on statistical physics and Pattern Oriented Modeling techniques to develop a set of robust techniques to express such pattern dynamics in state space of relatively small dimensionality. Viability theory will provide a framework for an inclusive, rigorous and practical definition of resilience, which give possibilities to find sets of actions to maintain or restore the satisfactory pattern dynamics. We shall test the methods and the software tools on a set of concrete applications, in collaboration with field specialists.We shall build on the tests to refine and improve the methods and tools. The applications include: bacteria dynamics, land-use in semi-arid savannas, learning of sequences in basal ganglia, language variety, biotech firm networks. We expect the use of these new methods to bring new knowledge about the resilience of these systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International and intersectoral mobility to develop advanced scintillating fibres and Cerenkov fibres for new hadron and jet calorimeters for future colliders' (INTELUM).

assistant: **Innovation**

Currently, new concepts are being considered for hadron and jet calorimetry in high energy physics experiments, in order to improve the energy resolution of these detectors by a factor of at least two. This is a prerequisite for future studies at the high luminosity, large hadron collider as well as at future electron and proton colliders. Amongst the few concepts being proposed, scintillating and Čerenkov fibres are considered very promising candidates.The INTELUM project will be a 4 year project funding international, industry-academia exchanges to develop micro-pulling-down crystal growth and other new types of fibre technology. This new fibre production technology has the potential to enable fast, low-cost, manufacture of heavy crystal scintillating fibres.In order to prove the new fibre technology concept, two key technical issues will be addressed during the project:• demonstrate feasibility of producing between 20-200km of fibres with consistent quality and well defined production costs• demonstrate sufficient radiation hardness of the fibres that the degradation of their optical properties is below 10% at 1 MGy levelThis ambitious project will be undertaken by a truly international consortium of sixteen institutes and companies, many closely linked to the Crystal Clear Collaboration. The project will also lead to important impacts in other domains such as functional medical imaging and homeland security.