RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Relaxed Semantics Across the Data Analytics Stack', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The RELAX European Doctoral Network aims to train a cohort of highly mobile and adaptable researchers to become experts in the design of scalable and efficient data-intensive software systems. These experts will master the specific skill of navigating the semantics or correctness conditions of applications, with the goal of enhancing scalability, response times, and availability. Working across the disciplinary specialisms of data science, data management, distributed computing and computing systems, the Fellows will develop knowledge of the broad issues underpinning data analytics systems. The bespoke training programme fosters intellectual enquiry and combines technical and scientific research training with courses in innovation, management and leadership. The training network addresses a critical skills gap in data analytics expertise, which needs urgently addressed to support innovation and employment in a fast-growing European data economy. The 14 partner organisations representing 8 countries will benefit first-hand through intersectoral collaboration and an Open Innovation model.


**Keywords:** data analytics, relaxed semantics, data quality and representation, coordination and synchronisation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Smart materials with switchable surface for effective removal of forever chemicals', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Per- and polyfluoroalkyl substances (PFAS), often called “forever chemicals”, are persistent and toxic pollutants widely detected in water, while conventional adsorbents struggle with low selectivity, poor short-chain PFAS removal, and energy-intensive regeneration. This project introduces a smart, temperature-responsive hydrogel platform that exploits the intrinsic hydrophobicity of long-chain PFAS and hydrophilicity of short-chain PFAS for their selective removal. Integration of photothermal materials will enable solar-driven, zero-energy switching without extra heating energy. Around the lower critical solution temperature (LCST, ~32 °C), the hydrogel surface has switchable characteristics: above LCST, the surface turns to hydrophobic to capture long-chain PFAS while releasing short-chain species; below LCST, the surface transforms to hydrophilic to adsorb short-chain PFAS and release long-chain ones. This principle allows selective and effective removal of both long- and short-chain PFAS. The introduction of fluorinated and cationic monomers could catch the fluorinated alkyl tail and the anionic head of PFAS via fluorophilic and electrostatic interactions , respectively, thereby enhancing the selective capture of PFAS by smart hydrogels. Machine learning will guide optimal monomer combinations, accelerate synthesis and optimize performance. Scalable formats (beads, membranes) will be validated in real-water continuous-flow tests with techno-economic analysis. By combining material science, computational modelling, environmental engineering, and sustainability assessment, this project will deliver a selective, regenerable, and cost-effective PFAS treatment technology, supporting EU Green Deal and Zero Pollution goals, and providing a transferable framework for the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Design optimisation of aluminium structures in shipbuilding' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The economic development and integration of Europe is being accompanied by an ever-increasing demand for mobility of people and goods. Meeting this demand asks for new approaches in all sectors of transportation. For the shipping trade, one of the implications is that there currently is a need for fuel-effective vessels that are capable of taking a relatively high payload directly to its inland end destination. Lightweight materials will play a key role in realising such vessels. Theme of the proposed project is the conceptual development of a lightweight, shallow-draught inland-water cargo ship. To successfully exploit the assets of such lightweight materials as aluminium, new methods of shipbuilding should be developed rather than adapting the current ones for steel. This requires several designing and manufacturing issues to be addressed. The significant increase in the use of aluminium for simple standardised ships, following this new approach, is to result in a draught reduction of 40% as compared to conventional ships. In effect, these vessels should be able to sail waterways of 1.0 m minimal depth or less; this correspondingly improves their employability and functionality for inland-water operation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of Long-Term T cell Memory against M. tuberculosis' (TB-MEMORY).

assistant: **Innovation**

The ability of T cells to respond to a second encounter with antigen is an essential element of memory immunity and indeed a prerequisite of a successful vaccination. Many recent advances have been made in our understanding of the cellular basis of immunological memory (reviewed by Kaech) (1). However, major gaps in our knowledge on the generation and persistence of cell mediated immunological (CMI) memory still exist. In particular, factors that allow vaccines to generate long-lived memory are still not understood. It has been suggested that this may be one of the major drawbacks of non-replicating vaccines such as recombinant subunit vaccines (1).In this regard, mice cleared of an infection with tuberculosis (TB) respond vigorously upon re-exposure to mycobacteria and are efficiently protected against re-infection, whereas the efficacy of some subunit vaccines declines over time as shown in fig. 1. The reasons for this are unknown. This data clearly demonstrates the need of more fundamental studies of immunological memory induced by vaccines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Antigenic and Topographical Imprinting of Human B Cell Memory and Its Reprogramming Potential' in the context of a Horizon Europe call.

assistant: **Objectives**

The novel COVID-19 vaccines have effectively reduced morbidity and mortality but unexpectedly failed to provide long-lasting sterilizing immunity. While specific serum antibody (Ab) titers were durable, local upper respiratory tract (URT) mucosal Ab responses were surprisingly short-lived. This shows both our lack of and need for a deeper understanding of URT mucosal immunity and its distinctions from systemic immunity. My proposal is designed to answer two key questions arising from this: How does the initial exposure site—mucosal or systemic—shape and imprint immune memory? And how is this imprinting reprogrammed by subsequent exposures via different exposure routes?In the TopBMemory project, I will: (1) delineate how the antigen (ag) nature and primary exposure site shape human memory B cell (MBC) subset heterogeneity and their imprinting. I will generate the first single-cell (sc) multiomic profiles of ag-specific (ag+) MBCs with context-specific imprints by a project-specific pipeline integrating transcriptomic, epigenomic, and phenotypic data. (2) Determine how alternative re-exposure sites reprogram existing imprints—overwrite or complement them—which will be the first demonstration of the potential for natural imprint reprogramming in MBC. (3) Test targeted reprogramming of MBC subsets within tonsil and nasal mucosa-derived organoid co-culture systems. My findings will significantly advance understanding of MBC ontogeny and plasticity, both in host protection and also immunopathologies, and inform the development of a new generation of vaccines and therapies.The groundbreaking nature of TopBMemory lies in its first large-scale contextualization of human ag+ MBC subset origins and functions, exploring their responses and adaptions to varying routes of ag re-expos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Biointelligent Production Sensor to Measure Viral Activity'.

assistant: **Concept**

We aim to transform virus biomanufacturing processes and enable new quality control strategies by a continuous, real-time capable biohybrid sensor technology to detect cell-based virus infection cycles. BioProS sensor concept makes use of an optical sensor technology in combination with cell-based measurement principles. In this context a platform technology will be developed that can be adapted to multiple specific analytes which enables its applicability in different industries and production settings. The development of such platform technology together with its technological complexity requires the involvement of multiple stakeholders throughout Europe and across disciplines (biology, engineering science, data science, manufacturing experts). Digitalisation has to extend from the very beginning of the process into the whole manufacturing chain, utilising all advances achieved in smart and lot-size-one manufacturing in recent years. This leads to the closely intertwined interaction of technical, informational and biological systems also referred to as bio-intelligent systems. This new paradigm opens up a large new space for innovations, recognised as a strategic field in America, Asia and Europe. Based on the manufacturing excellence leadership of Europe, BioProS will significantly contribute to all expected impacts of the Destination “Digital and Emerging Technologies” and explicitly to each of the four expected outcomes of this call topic. The consortium aims to gather all required expertise and set the basis for international partnerships. In close cooperation with pan-European initiatives and with the support of an industry advisory board, project partners aim to transform the vision of bio-intelligent manufacturing and demonstrate the applicability of disruptive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INNOVATIVE FUNCTIONAL PAINT FOR AIR PURIFICATION' under Horizon 2020.

assistant: **Concept**

AM Technology Ltd is an SME founded with the objective of successfully developing and commercialising innovative functional paints based on AIRLITETM technology, an air purification technology based on the photocatalytic oxidation effect of Titanium dioxide (TiO2). The paints based on AIRLITE  are capable of transforming any architectural surface into a natural air purifier, using only the energy of light, making no noise and requiring no maintenance. AIRLITETM can be used for both indoor and outdoor environments, making it a real and effective solution for effectively solving poor air quality issues at a reasonable cost. AIRLITE is a unique technology in the sense that it brings together an exceptional performance in terms of air purification  (well above any other photocatalytic paint) and some other additional characteristics and advantages:AIRLITE reflects the hot component of sunlight, preventing the passage of excessive heat, which remarkably reduces the energy consumption needed to cool indoor environments.AIRLITE eliminates mould, bacteria and bad smells, and repels dirt. AIRLITE generates a high concentration of natural disinfectants which kill more than 99.99% of bacteria in the treated environment.Other advantages: Safety (is completely free of Volatile Organic Compounds (VOCs)), high durability (lifetime extended by twice that of normal paint resulting in less repainting costs), and a very low price (6 times less than existing photocatalytic paints).On their way to the market, AM Technology have developed some preliminary AIRLITE based products, and conducted an early stage commercial validation phase with them. This validation demonstrated the business viability of the project and identified the tasks and activities that need to be undertaken (from a techni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Extracellular Matrix in Epileptogenesis' (ECMED).

assistant: **Concept**

Over 50 million people worldwide have epilepsy and 30% are resistant to our present therapies. Epilepsy, therefore, comprises a major burden to society and so there is a pressing need for new approaches to treatment. The brain extracellular matrix (ECM) plays a critical role in governing brain excitability and function. Although research into the role of the ECM in neuronal signalling and network function has advanced considerably in recent years, its full translational potential has yet to be realised. There is growing evidence for a major role of the ECM in epilepsy including the association between ECM protein mutations and epilepsy, changes in the ECM and associated proteins during the development of epilepsy and the strong association between the ECM and brain diseases associated with epilepsy including stroke, traumatic brain injury, neurodegeneration and autism. This proposal brings together considerable expertise from academic and industry partners in the biology of the ECM with experts in epilepsy research. This, therefore, represents a truly collaborative effort to determine not only the role of the ECM in the development of epilepsy but also novel approaches to treat and to prevent epilepsy.The academic partners will focus on specific research questions, whilst the industrial members will provide diagnostic, treatment and advanced research tools. The project has a strong translational theme and the combination of basic and translational science will be of great benefit for the training of young researchers.Trainees will be exposed to courses, workshops, joint research meetings and inter-laboratory visits. The focus of the training programme is on expanding knowledge and the application of such knowledge to address pertinent question relevant to the diagnosis,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Image-Guided Surgery (IGS) and Personalised Postoperative Immunotherapy To Improving Cancer Outcome'.

assistant: **Concept**

The basic concept of our proposal is to develop nanoparticle-based encapsulated libraries of different immunotherapeutic biomolecules for treatment after surgery as part of a novel cancer management strategy. The current state-of-art for the management of cancer starts with surgery, after identification of an accessible tumour mass. Surgery remains an effective treatment option for many types of cancer today and it is considered curative treatment for most solid tumours. It forms part of a multidisciplinary approach used in conjunction with radiotherapy or chemotherapy. These approaches, however, have several limitations, including inability of surgical resection to affect distal metastatic disease, toxicity to healthy tissues with chemotherapy and lack of effectiveness of radiation therapy in more aggressive tumours. The observation that cancer can relapse months or years after initial surgery implies that micrometastases still resides within the body in a latent state. Our proposal is to take cancer therapy to beyond state-of-art by implementing techniques which will take us into new directions. This includes a) new methods to identify immune gene profiles and biomarkers b) transgenic mouse models where the complex interactions that underlie immune function can be visualised as multiplexed events in real time and c) the use of nanoparticle-based libraries of immune modulating reagent combinations. There are three key objectives within this project: i) to use immune gene signatures to monitor disease progression and therapeutic efficacy of immunotherapy combinations on nanoparticle-based platforms, ii) to optimise the platform to encapsulate libraries of immune components for more personalised, accurate and timely delivery of the payload to its intended target and iii)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Resist no-resistance : mobilising the research efforts for combating multi-resistance against anti-biotics (ROR)' in the context of a Fifth Framework call.

assistant: **Objectives**

There is a growing awareness in the scientific and public health community that multi-resistance against antibiotics is an increasing threat. This pandemic is caused by the inappropriate use of antibiotics in human and veterinary medicine, and often the lack of hygienic standards in health care facilities. Presently, the organisation and coordination of research efforts is insufficient to lead to the required scientific breakthroughs. The focus of the project ROR is to investigate the scientific and operational feasibility of a structured approach of the European research efforts, taking into account all existing initiatives and future needs of research and surveillance-activities, and to describe the critical conditions for an effective and purposive joint European research policy. It will lead to a European Road Map for future research actions in this field for policy-makers, researchers and industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Functional mri of cerebral responses to centrally-acting pharmacological agents' (PHARMACOLOGICALMRI).

assistant: **Concept**

Use of functional MRI to determine the effects of brain-penetrating pharmacological agents on brain perfusion; investigations will be carried out in anaesthetised and conscious animals, investigating additionally the effects of anaesthetics and pulse sequences on drug responses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Semantic Interoperability for Health Network' under Seventh Framework.

assistant: **Concept**

SemanticHealthNet will develop a scalable and sustainable pan-European organisational and governance process for the semantic interoperability of clinical and biomedical knowledge, to help ensure that EHR systems are optimised for patient care, public health and clinical research across healthcare systems and institutions.Through a clinically-driven workplan, exemplified in cardiovascular medicine, SemanticHealthNet will capture the needs for evidence-based, patient-centred integrated care and for public health, encapsulating existing European consensus in the management of chronic heart failure and cardiovascular prevention. Experts in EHR architectures, clinical data structures, terminologies and ontology will combine, tailor and pilot their best-of-breed resources in response to the needs articulated by clinicians and public health physicians.These exemplars will be cross-referenced with other domains and stakeholder perspectives via Clinical and Industrial Advisory Boards and interactions with other projects in Topic 5.3. The project will generalise and formalise the methods and best practices in how to combine and adapt informatics resources to support semantic interoperability, and how these can be developed and supported at scale. Health authorities, clinical professionals, ministries, vendors, purchasers, insurers are involved to ensure the project approach and results are realistically adoptable and viable, building on the SemanticHEALTH and CALLIOPE roadmaps.A business model to justify strategic investments, including the opportunity costs for key stakeholders such as SDOs, industry, will be defined. This, and links with epSOS II and the eHealth Governance Initiative, will inform the shape of the Virtual Organisation that this Network will establish to sustain