RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards a kinematically complete investigation of radiation-induced biomolecule fragmentation' (KICOBIOFRAG).

assistant: **Concept**

I propose to investigate radiation-induced dissociation of DNA building blocks by coincident determination of the momenta of the collision products. The unprecedented possibilities, arising from the development of reaction microscopes and the advent of high- speed digitizers, render even kinematically complete studies possible. Cross sections for different dissociation channels as well as momenta of fragment ions and emitted electrons will be measured.The proposed studies have their direct application in the context of biomolecular radiation damage: The biological effects of ionising radiation in living cells are not a mere result of the direct impact of high energy quanta of radiation. Secondary particles such as low energy electrons, radicals and (multiply charged) ions are formed within the track. The interaction of these secondary particles with DNA is responsible for a large fraction of biological radiation damage to a cell. For a quantitative understanding of this damage I thus plan to investigate the interaction of ionising radiation with molecules naturally surrounding DNA in the cell nucleus (proteins, water, DNA building blocks). The obtained data can be used as an input for track structure calculations to estimate biological radiation damage potentials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Iwasawa theory of p-adic Lie extensions' under Seventh Framework.

assistant: **Concept**

One of the most challenging topics in modern number theory is the mysterious relation between special values of L-functions and Galois cohomology: they are the “shadows” in the two completely different worlds of complex and p-adic analysis of one and the same geometric object, viz the space of solutions for a given diophantine equation over the integral numbers, or more generally a motive M. The main idea of Iwasawa theory is to study manifestations of this principle such as the class number formula or the Birch and Swinnerton Dyer Conjecture simultaneously for whole p-adic families of such motives, which arise e.g. by considering towers of number fields or by (Hida) families of modular forms. The aim of this project is to supply further evidence for I. the existence of p-adic L-functions and for main conjectures in (non-commutative) Iwasawa theory, II. the (equivariant) epsilon-conjecture of Fukaya and Kato as well as III. the 2-variable main conjecture of Hida families. In particular, we hope to construct the first genuine “non-commutative” p-adic L-function as well as to find (non-commutative) examples fulfilling the expectation that the epsilon-constants, which are determined by the functional equations of the corresponding L-functions, build p-adic families themselves. In the third item a systematic study of Lie groups over pro-p-rings and Big Galois representations is planned with applications to the arithmetic of Hida families.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Identification of tumor-associated peptides presented by hla molecules from colon carcinoma cells' in the context of a Fourth Framework call.

assistant: **Objectives**

Stimulation or adoptive-transfer of tumor-specific T cells are, at present promising new lines in cancer immunotherapy. For melanomas, tumor-selective peptides presented by HLA-molecules to cytotoxic T cells (CTL) have been identified, first clinical trials being underway. For many other tumors including colorectalcarcinomas, relevant information is not yet available, although candidate antigens for tumor-specific immunity are known, including mutated-RAS. The objective of this proposal is to definitely identify HLA-class-one presented peptides of mutated-RAS and other tumor-associated proteins (ex: p53 CEA) by a purely biochemical approach. Large number of colorectal-carcinoma cells will be produced, either by in vitro culture or by expansion in nude mice of cell lines already established at INSERM U395. HLA-molecules will be precipitated and associated peptides will be extracted using procedures well established in Dr. Rammensee's group. Resulting peptide mixtures will be screened by mass-spectrometry for peptides conform with those predicted based on the protein sequence of the candidate antigens and allele-specific HLA motifs that have been determined in Dr. Rammensee's laboratory. Results are expected to give the basis for experimental immunotherapy of colorectal-carcinomas, using peptide specific CTL.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Health in Times of Transition: Trends in Population Health and Health Policies in CIS Countries'.

assistant: **Concept**

Goal: To understand long-term trends of population health as a consequence of socio-economic transitions, with a focus on lifestyle-related issues.  Overviews: A unique team with extensive expertise in health effects of transition will generate new knowledge on health determinants in 11 CIS countries: Russia, Belarus, Ukraine, Moldova, Kazakhstan, Uzbekistan, Kyrgyzstan, Armenia, Azerbaijan and Georgia.  It employs a model of health determinants acting at individual and societal level, with distal and proximal influences on health. It focuses on alcohol, tobacco, diet, and health care, each linked to diseases specified in the call.   Objectives: a) measure and explain prevalence and distribution of risk factors, health outcomes, and their social, cultural, and economic determinants; b) develop and implement validated community profiles to capture the opportunities and obstacles to leading a healthy lifestyle (in relation to diet, alcohol, smoking); c) assess health system performance, focussing on  accessibility and quality of health services; d) quantify the cost of ill health through reduced labour supply and productivity; e) identify opportunities for and obstacles to policy change (alcohol and tobacco) in Russia: f) market analysis (alcohol & tobacco); g) regional analysis of alcohol -related mortality in Ukraine.  Methods (corresponding to objectives):  a) Large scale household surveys, multiple regressions; b&c)  Rapid appraisal using structured observation, mapping, media analysis, interviews, focus groups d) econometric modelling (instrumental variables) e) stakeholder analyses f) econometrics g) multivariate analysis  Finally, the project will bring concrete benefits by influencing policy in ways that will support health by: · disseminating findings within each
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Integrated shipcontrol system for small tonnage and fast shuttle ships'.

assistant: **Objectives**

During the last ten years the overloading of the road systern and environmen has increased drastically as a result ofthe growth of truck-trafflc with over 65 %. It has proved to be essential to improve the competitiveness ofthe waterborne trafflc in order to deminish this environment hazardous progress. The essential part ofthe progress is effective use of small tonnage. There is a cap in navigation technology which irnpedes the safe and effective navigation on narrow waterways and in harbour-areas. The specific objective of this research is to lessen these obstacles by developing a novel integrated shipcontrol system (ISC), the kernel of which is a laser based short range navigation and automatic mooring system. The system will at the sar allow higher speed in harbour operations and decrease the possibil accidents. According to the maritime accident statistics, in 35 % of the cases the dangerous situation was sighted too late and in 40 % not at all. system will be based on image processing of laser rangefinder data and is supported by GPS or dead-reckoning. It is estimated that the new system will deminish 30% of accidents owing to svigation errors, enabling savings of 5% in insurance contribution as well as in nurnber of effective working days. The system will increase the effectiveness of shipoperators by 5-10% and it is estimated to lead to annual investments of 10 MECU.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'REsearching Legal Implementation of an Intersectional Framework: a feminist sociolegal analysis of opportunities and obstacles' to be submitted under Horizon Europe.

assistant: **Abstract**

RELIEF (REsearching Legal Implementation of an Intersectional Framework: a feminist sociolegal analysis of opportunities and obstacles) explores the implementation of intersectionality as an anti-discrimination framework in legislation, legal praxis and public policies with an interdisciplinary feminist approach. Intersectionality originates as a legal critique to understand how gender intersects with other axes of discrimination (sexual orientation, ethnicity, religion, nationality, disability, and socioeconomic status) and RELIEF aims to investigate how legal implementation of intersectionality can address a more diverse and complex understanding of discrimination from a law-in-action perspective. This project will enhance my sociolegal research skills on gender equality and anti-discrimination within the EU multilevel legal framework under the supervision of Dr. La Barbera at the Spanish National Research Council (CSIC) and in affiliation with the Gender and Politics (GEYPO) research group. At the same time RELIEF will contribute to feminist theory building by investigating how public institutions can effectively implement an intersectional framework. To achieve this goal, RELIEF conducts a sociolegal analysis of Spain’s anti-discrimination law, focusing on institutional actors, academic experts and civil society, combining legal analysis, qualitative and participatory methodologies. With a feminist participatory approach RELIEF directly engages stakeholders, connecting the scientific goals with the wider expected social impact and bridging the gap between sociolegal research, legal implementation and activism. RELIEF’s empirical evidence enriches the theoretical debate on the institutionalisation of intersectionality, co-produces transformative knowledge and provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'dEUdil: Building on open data as a new business model in the business information industry'.

assistant: **Concept**

DueDil is on a mission to contextualise the world’s private company information and, in the process, to do for private markets what Bloomberg has done for public ones. At the heart of DueDil’s success is a big data platform built on top of open data that leverages geo-localisation and network analysis techniques. This combination of our data processing architecture and proprietary algorithms enables us to shift the paradigm of the business information industry with a product that offers superior data contextualisation and usability and unprecedented transparency. By creating tools on top of open data, we are innovating in the business information industry in a way that is simply unavailable to the traditional incumbents who have grown through acquisition rather than innovation. We are well established in the UK & Ireland and the next step is pan-European expansion. To this end, we are seeking a grant to strengthen our technology backbone and enable the scaling and gradual localisation of our services from 2 to 19 European Member States (MS). We aim to create a unified database of company and corporate director information across the 19 MS with information matched and searchable seamlessly within and across the 19 MS. We will also start building our continental Europe business development capacity for those new markets centrally from London, rolling out our solution incrementally across Europe. By removing the major, widely acknowledged barrier to growth: finding new business and risk managing suppliers and customers by providing access to business information of unprecedented transparency, we believe DueDil can become a powerful growth and job creation engine for Europe and thus generate a massive return for European taxpayers’ money. To achieve this, we have assembled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigation of interfacial structure of buried inorganic-organic interfaces in organic photovoltaics -- LiF at organic-cathode interface' (LIFORGANICPV).

assistant: **Concept**

In order to improve the efficiency of organic microelectronic devices,  there has to be a better understanding of both the connection between the crystalline structure and device performance, and the role that the organic/organic and inorganic/organic interfaces play in determining that structure. The main objective of the proposed research project is  understanding the role of structure in solar cell efficiency and using control of that structure to produce a device with improved efficiency.  In order to reach that goal, the work is aimed at establishing  the structure of LiF on the surface of an ordered organic thin film, exploring the impact of deposition of LiF on the order of the underlying organic molecule, and relating  any changes in structure near the interface to device performance. The intention would be to produce a small molecule solar cell with improved power efficiency achieved by modification of the organic/inorganic interfacial order.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Time resolved superexcited state dynamics'.

assistant: **Innovation**

Understanding ultrafast molecular dynamics that govern the evolution of excited systems allows modeling, predicting and in some cases controlling the outcome of chemical reactions. Using femtosecond (fs) laser pulses to initiate and probe dynamics, we provide insight into the important quantum mechanical mechanisms that control molecular dynamics. However, range of excited dynamics that can be addressed is limited by the wavelengths of readily available laser systems. Specifically, superexcited states, which are states that lie above the threshold for electron emission, can not be initiated directly from neutral molecular ground states with conventional laser systems. Such superexcited states exhibit extremely non Born-Oppenheimer dynamics, as electron and nuclear motion dynamics compete on ultrafast timescales, often leading to fragmentation rather than electron emission. Therefore, I propose to extend the range of investigated ultrafast phenomena to include superexcited state dynamics. Such states will be accessible with conventional fs lasers, not from neutral ground state molecules but from fast beams of negative ions or metastable neutral species that are energetically close to superexcited states. Furthermore, fast beam fragment imaging techniques will be used to record time resolved kinetic energies and correlations of fragmentation products. Specific objectives of this proposal are (i) to investigate time resolved dynamics of superexcited negatively charged water clusters; (ii) to investigate fragmentation dynamics of superexcited H3* states. The contribution of the MC-IRG will provide necessary funding to cover project expenses. In this way, MC-IRG will contribute to the training of students and to the transfer of knowledge I have acquired in the USA to researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Engineering of an Artificial Capsidic Enzyme for Aqueous Dirhodium Catalysis'.

assistant: **Innovation**

Artificial metalloenzymes are expected to bring together the best of the two worlds of homogeneous and enzyme catalysis, combining broad substrate scope with high activity and reaction selectivity under mild conditions. Herein we propose to construct an artificial metalloenzyme based on a dirhodium active site in the capsid scaffold of the protein ferritin. Catalytically competent dirhodium compounds are derived from dirhodium tetraacetate, which possesses fourfold symmetry, with the ligands symmetrically arranged around the equator of the rhodium dimer. The transition metal core is active in a wide range of reactions including cyclopropanation, C-H activation and O-H insertion. These transformations play an important role in the synthesis of natural products, pharmaceuticals, and other industrially relevant targets. We will exploit the fourfold-symmetric pores of the capsidic protein ferritin to construct a dirhodium binding site. A ferritin mutant will be produced with four glutamate residues pointing in the channel lumen, suitable as ligands for the rhodium dimer. After derivatization with dirhodium the artificial capsid will be employed as a catalyst in organometallic reactions, such as the cyclopropanation of diaza carbonyl compounds with olefins in aqueous solution. The catalytic properties of this first dirhodium enzyme will be fine-tuned by the highly modular secondary ligand environment of the protein. The dirhodium binding site will also be introduced at the inner mouth of the fourfold channel, resulting in an active site inside the capsid. High local substrate concentrations and the presence of a second, complementary reaction center inside the capsid might allow multi-enzyme cascade catalysis, thus paving the way toward artificial nanoreactors with tailored
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Early stage coronary disease study with a new high resolution semiconductorsgamma camera', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Myocardial scintigraphy and radionuclide ventriculography at equilibrium are considered the best methods for the diagnostic of coronary disease and the assessment of myocardial performance and therapy follow-up.Until now, the heavy equipment of conventional gamma-camera requires to immobilise the cardiac patient in a nuclear medicine department, usually for the assessment of heavy pathologies. This situation is unfavourable to address two clinical issues which would require light portable equipments :the detection of transient ischemia, at the very early and silent stage of the coronary disease, in the apparently healthy and ambulatory patient,the exploration of cardiac function at the first stage of myocardial infarction, in the intensive care unit, to improve both the prognostic, the therapy follow-up and the comprehensive study of the tissue injury and reperfusion.Cadmium Telluride semiconductors have been chosen to conceive a new pixellised nuclear probe, because of their high sensitivity and high energy resolution, providing excellent spatial and contrast resolution for imaging. Such detectors can constitute the sensitive area of a light probe associated to a computer for data processing and image reconstruction in real time. This ensemble can be easily moved to the patient, either for ambulatory dynamic studies or for cardiac function assessment in an intensive care unit.The industrial partners have defined their work tasks to build a light weight high resolution g-camera. Small size Cd Te detectors, 3 mm * 3 mm * 2 mm, allow their disposition in a 48 * 48 array (2304 independent pieces) in a 15 cm * 15 cm sensitive area designed to overlap the cardiac chest area. The array is divided in 12 blocks of 12 parallel modules inserted on a mother card. Each module is a