RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multi-modal Optical Diagnostics for Ocular and Neurodegenerative Disease' (MOON) under Horizon 2020.

assistant: **Objectives**

The rising life expectancy of EU citizens is creating a dramatic increase in age-related degenerative diseases and associated healthcare costs. The MOON Project (Multi-modal Optical Diagnostics for Ocular and Neurodegenerative Disease) meets this societal challenge by applying photonics to diagnose age-related diseases of the eye and central nervous system. Consistent with the ICT-29-2016: Photonics KET 2016 Work Program, MOON will design and build a multi-band, multimodal and functional imaging platform combining label-free molecularly sensitive Raman spectroscopy with high speed and high-resolution Optical Coherence Tomography (OCT), for in-depth diagnostics of ocular and neurodegenerative diseases. MOON will enhance OCT – already the gold standard of retinal imaging - through the development of a disruptive laser technology that enables wide-field structural and functional imaging. MOON will establish a reference database for molecular biomarkers of addressed diseases that enables, for the first time, in-depth molecular-specific diagnosis of retinal diseases and neurodegenerative pathologies based on Raman spectroscopy. The MOON system will be validated in vivo in a clinical setting through close collaboration between clinicians and commercial partners. The clinical validation will establish the diagnostic accuracy of the multi-modal platform, while also verifying the ease-of-use needed for widespread adoption. MOON is driven by unmet medical user needs in diagnostic imaging with a clear business case addressing the highly promising ophthalmic market of early and in-depth molecularly sensitive diagnostics of retinal and neurodegenerative diseases. The three industrial partners cover the complete value/supply chain. MOON aims to bridge the gap between research and pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional cartography of intestinal host-microbiome interactions' in the context of a Horizon Europe call.

assistant: **Objectives**

Microbiome-host crosstalk is crucial for gut homeostasis and its dysregulation is a hallmark of diseases such as colorectal cancer (CRC) and inflammatory bowel disease (IBD). Despite its key relevance for a holistic understanding of the human superorganism and its (patho-)physiology, how local host-microbiome interactions form specific niches in the gut and how these niches function at the cellular and molecular level remains unexplored, mainly due to a lack of suitable technologies.To fill this gap, we propose to jointly reconstruct the host transcriptional and microbiome compositional landscape of the human gut across a large number of healthy individuals as well as IBD and CRC patients. For this, we will leverage a combination of novel spatial profiling technologies for unbiased transcriptome sequencing and microbiome profiling at single-cell resolution in situ. First, we will spatially delineate local niches formed of specific microbes and host cells. To dissect this complex crosstalk into specific interactions, we will secondly use in vitro and in vivo models to introduce perturbations either on the host or the microbiome side. Finally, we will integrate the resulting data to deconvolute host-microbiome circuits computationally and to predict functional niches, in particular host responses to pathogens of relevance in IBD and CRC. Interesting predictions will be tested in organoid and animal models. Developing a spatially resolved computational model of the gut ecosystem will allow us to predict early local events in disease onset; from these we will identify and validate prognostic IBD and CRC biomarkers for future clinical translation.This work will revolutionize our understanding of intestinal host-microbiome interactions by adding a first-ever functionally reso
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RAPID DETECTION SYSTEMS FOR MOULD CONTAMINATION' in the context of a Fourth Framework call.

assistant: **Objectives**

Fungal contamination of food and feeds causes considerable economic losses aswell as posing a health threat to the consumer, because of mycotoxin production.Current methods for detection of fungal infection in foods are time-consuming andinsensihve and do not make use of recent technological developments in analyticalmethods. The proposal combines the complementary expertise of four researchgroups in Europe in a coordinated assay development and va]idation programme.The primary objective of the project is to develop and validate rapid andconvenient broad-specificity assays for general fungal contamination of cereals,which will be applicable to boffi laboratory and field use. The emphasis will beplaced on immunoassays based on broad-spectrum antibodies to fungal mycelialproteins and also antibodies to ergosterol, a fungal sterol. Instrumental methods(NIR/NIT, electronic nose) for ergosterol detection will also be examined and allmethods compared with traditional methods. The study will give a useful insightinto the antigenic composition and molecular characterisation of common fungalcontaminants of cereals, which will contribute to the setting up of speedierclassification systems for novel fungal species.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Patient-specific treatment for Parkinson's disease using reprogrammed skin cells'.

assistant: **Innovation**

Cellular reprogramming is a new and rapidly emerging field where somatic cells can be turned into pluripotent stem cells or other somatic cell types simply by overexpression of specific combinations of genes. This remarkable discovery allows for the generation of patient specific cell lines that will serve as major tools for understanding how diseases arise and develop, and they may also prove useful for drug screens, diagnostics and other biomedical applications. We have developed a reprogramming technique that directly converts human fibroblasts to functional dopamine (DA) neurons, which is the subtype that is affected in Parkinson’s Disease (PD). This opens up for possibilities to generate therapeutic neurons, including patient specific neurons on demand. These neurons, and the techniques for producing them, will become valuable tools for understanding and treating neurodegenerative diseases such as PD. Direct cell conversion is of particular interest for cell replacement therapy as the reprogramming does not involve a proliferating cell intermediate, and thus the risk of uncontrolled proliferation and tumor formation after transplantation is minimized. This project integrates mechanistic studies based on single cell sequencing to improve the technology and control of cell fate such that a large number of authentic DA neurons are obtained. Induced DA neurons will be generated from individuals with PD and age matched healthy donors and subjected to comparative assessments in vitro and in vivo in order to investigate whether any potential PD-associated pathology emerges in the patient derived cells. This will then guide future decisions regarding autologous vs. allogeneic donors. The cells will be extensively validated using pre-clinical animal models of PD. The studie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Molecular interactions in nucleus and cytoplasm regulating HIV/host cell relationship : from basic research to antiviral intervention' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To progress in the basic knowledge of host cell/HIV genome relationship in order to better adapt future antiviral therapies to the strategies of latency, reactivation and replication used by HIV to persist in immunocompetent cells and suppress their functions.Five teams from France, United Kingdom and Spain imbricate their efforts to characterise molecules targetable for antiviral intervention, on the base of their participation in the transduction and transcription pathways controlling the expression of integrated HIV provirus in immunocompetent cells that are natural targets of HIV infection, namely CD4 T lymphocytes and macrophages. The project focuses on the following aspects :- Characterisation of the IkappaB kinase and/or phosphatase directly controlling the phosphorylation, ubiquitinylation and degradation of IkappaB resulting in activation of NF-kappaB.- The regulation of nuclear import and export of NF-kappaB and IkappaB, and the mechanism of termination of NF-kappaB function by nuclear translocation of IkappaB.- The role of interactions between NF-kappaB and IkappaBalpha in the control of HIV genome transcription in transformed and normal T cells and macrophages.- The influence of HIV particles, whether infectious or not, on the above events and on the regulation of transduction pathways controlling T lymphocyte activation and viability.- The effects on the NF-kappaB system of non-toxic compounds capable of dissociating NF-kappaB translocation and activity, and suppressing HIV replication.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Safety and reliability of industrial products, systems and structures' to be submitted under Fifth Framework.

assistant: **Abstract**

The Thematic Network is concerned with providing safe and cost effective solutions to industrial products, systems, facilities and structures across different industries. The scope of the project is the integrated treatment of the important aspects of design, production, operation of industrial products, systems and structures. The main emphasis is on the use of reliability-based methods for the optimal design of products, production facilities, industrial systems and structures from the point of view of balancing the economic aspects associated with providing predefined safety levels, with the associated costs of maintenance and availability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Ergoefficient mechanised logging operations'.

assistant: **Objectives**

The objective of Ergo wood is to give the European logging industry a better competitiveness through development of the organisation of logging operations and its machinery. Mechanisation is one way to reduce costs in logging, and to keep peripheral regions on the market. However, it must be done without jeopardising the operators' health. The project intends to find guidance on ergonomic matters. This will encourage the development of safe and efficient forest machines, as well as the improvement of the sustainability in human resources. The project also involves sharing good examples of work organisation. The measured effects will be presented in terms of economical, social and health output. Reliable cost/benefit methods will be developed making it easier to decide on ergonomic investments. The project has a significant input by the industry, which will ensure its practicality output.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Digital Marketplace to empower SMEs for the digital transformation' (UDIGITAL).

assistant: **Concept**

Digital Transformation is the complete transition of the business activities of a company to the digital realm. Thus, during 2017, over 80% of enterprises spent an average of 44% of their IT budget in their digital transformation. However, 84% of companies fail at this challenge since the current approach to digital application development is expensive, complex, time-consuming and fragile. On top of that, SMEs also face budget constraints, legacy system issues, and limited availability of skilled employees. But UGROUND, due to the use of semantic engineering, has created a high productivity platform- patented in the USA- that provides total flexibility and enables SMEs to innovate very quickly and at a low cost. UDIGITAL is its cloud environment, where integrators will have access to our semantic engine (which interprets and proccess human knowledge), and to several different business model framework for each target market, addressing the specific needs of SMEs in those niches. Key straightforward benefits of our solution are: increase company competitiveness, including a 400% reduction of the development costs % (operation and programming times) and up to a 60% of the development effort (man hours and programming skills). As a result, the digital transformation investment ROI is less than one year. As it has been proved in our current clients our technology is able to increase over 99.5% the operational efficiency, and reduce up to 350,000 man hours.UDIGITAL is focused in supporting SMEs, which have an actual problem at digital transformation due to lack of internal expertise or limited resources to buy expensive platforms. Through this project, we aimto reach over 4000 clients, targeting sectors such as legal and consultancy services, manufacturing, human resources an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'APERIM: Advanced bioinformatics platform for PERsonalised cancer IMmunotherapy' to be submitted under Horizon 2020.

assistant: **Abstract**

Cancer treatment platforms that involve the use of the adaptive immune system have demonstrated profound tumour regressions including complete cure. Importantly, technological advances in next-generation sequencing (NGS) allow for the first time the development of personalised cancer immunotherapies that target patient specific mutations. However, clinical application is currently hampered by specific bottlenecks in bioinformatics, which we aim to address in this proposal. The overall objective of our trans-disciplinary network of leading experts in bioinformatics and cancer immunology is to develop an Advanced bioinformatics platform for PERrsonalised cancer IMmunotherapy (APERIM). Specifically we aim to develop: 1) database for the integration of NGS data, images of whole tissue slides of tumour sections, and clinical data. To enhance the usability and the data sharing we will use semantic web technologies, and will provide standardised interfaces to a set of analytical tools. 2) tools for automated quantification of tumour-infiltrating lymphocytes using whole tissue slide images and NGS data for patient stratification.3) analytical pipeline for NGS-guided individualised cancer vaccines including crucial NGS data analysis and epitope selection components for the selection of vaccination targets.4) a method for deriving T-cell receptor (TCR) sequences from NGS data and predicting TCR specificity.We will achieve these aims using unique training and validation datasets available to the consortium. We will develop user-friendly software modules as well as analytical standard operating procedures for clinical use, and apply the bioinformatics platform in clinical settings. The bioinformatics platform will considerably accelerate the clinical translation and maximise the ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Laser Scanning for Automatic Bridge Assessment' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Bridges on Europe’s transportation network are at risk due to increased freight demands, aging, environmental impact and climate change. Deficiencies of bridges must be assessed in a timely manner for planning critical maintenance, repairs and expansions. However, with bi-annual general inspections of bridges, damage may not be documented timely to prevent catastrophic collapse. Moreover, visual inspection is the predominant method that has many downsides: subjective results, slow and expensive procedures, high safety risks for inspectors and requirements of experienced inspectors, and traffic closures. Recently, although unmanned aerial vehicle (UAV)-based image has been developed for bridge inspection, results based UAV-images are of relatively low accuracy, which can be exaggerated when the images subject to shadows and noise. While several pieces of methods have been proposed to process data (both images and a point cloud), these approaches are not automatic, scalable and robust. Thus, to address those issues, the project “Laser Scanning for Automatic Bridge Assessment” called BridgeScan proposes the framework to use laser scanning integrated into UAV to acquire 3D topographic data points of bridges and to automatically process data for bridge assessment purpose. This project will involve (i) investigate a flight path and scanning parameters to scan a bridge structure by UAV with an integrated laser scanning sensor, (ii) develop automatic, robust, efficient methods to process laser scanning data to identify structural deficiencies for bridge condition rating and (iii) develop automatic methods for reconstructing a 3D bridge model for bridge assessment based on finite element analysis. Success of the BridgeScan project will be fundamental for further deploying UAV wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Affordable smart GaN IC solutions as enabler of greener applications' (ALL2GaN), addressing dissemination and exploitation.

assistant: **Impact**

ALL2GaN will be the backbone for the European Power Electronics Industry by offering an EU-born smart GaN Integration Toolbox. The project will provide the base for applications with significantly increased material- and energy efficiency, thus meeting the global energy needs while keeping the CO2 footprint to the minimum.46 partners from 12 European countries will collaborate on 8 major objectives along the entire vertical value chain of power and RF electronics.  O1: Push the limits of industrial GaN devices and system-on-chip approaches for ≤ 100V  O2: Leverage the full potential of innovative substrates for GaN  O3: Achieve novel benchmark solutions for lateral GaN devices and integrated circuits ≥ 650V  O4: Reach best technical and cost performance of RF GaN on Si with novel integration concepts  O5: Break the packaging limits by application driven integrated solutions of high performance GaN products  O6: Advance the methods to evaluate and optimize reliability and robustness of GaN components, modules, and systems for shortest time-to-market and maximum product availability at the end user  O7: Demonstrate highest affordable performance for greener power electronics and RF applicationsO8: Road-mapping for the future GaN technology development and applications to support long-term exploitation/business cases and European leadership beyond ALL2GaN.The collaboration in ALL2GaN is based on a work package structure covering activities on novel power- and RF-GaN technologies for various voltage classes, latest packaging technologies, research on reliability and demonstration in 11 Use Cases. With ambitious goals and a clear vision, ALL2GaN will unleash the energy saving and material efficiency potential of GaN semiconductors for a broad field of applications, thus bein