RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Targeting common oncogenes with intracellular monobodies', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Oncogenic signalling networks display a remarkable degree of plasticity. Despite only a limited number of alterations in oncogenes and tumour suppressor genes in most tumours, the majority of targeted therapeutics (monoclonal antibodies and small-molecule kinase inhibitors) does not strongly improve the survival of cancer patients and suffers from the rapid development of resistance. The rising number of targeted drugs in clinical use inhibits only a very limited number of protein targets (largely kinases). Consequently, most intracellular non-kinase oncoproteins remain untargeted. We have previously established the use of small engineered antibody mimics, termed monobodies, to potently and specifically target intracellular protein-protein interactions mediated by the SH2 domains of oncogenic kinases and phosphatases. Expression of SH2-targeting monobodies resulted in the inhibition of signalling and oncogenesis of these oncoproteins. Here, we aim at developing monobody binders to 10 key intracellular oncoproteins for which no chemical inhibitors exist and testing their activity in cancer cells. To enable a possible clinical translation of monobody-based therapeutics, we will develop methods to deliver monobody proteins into cells, including cell-penetrating peptides, bacterial toxins and biocompatible nanocarriers. 'Mirror-image' monobodies, composed of D-amino acids, will be developed and tested to increase intracellular and plasma stability and to limit immunogenicity. The developed monobodies and delivery systems are planned to be tested in mouse cancer models. Our goal is to establish monobodies as novel class of intracellular protein-based therapeutics. We hope to kick off their use beyond basic research tools towards possible applications in cancer patients. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Catalytic Carbene Insertion Reactions; Creating Diversity in (Material) Synthesis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

With this proposal the PI capitalises on his recent breakthroughs in transition metal catalysed carbene (migratory) insertion reactions to build up a new research line for controlled catalytic preparation of a variety of new functionalised (co)polymers with expected special material properties. Metallo-carbenes are well-known intermediates in olefin cyclopropanation and olefin metathesis, but the PI recently discovered that their chemistry is far richer. He demonstrated for the first time that metallo-carbenoids can be used in transition metal catalysed insertion polymerisation to arrive at completely new types of stereoregular carbon-chain polymers functionalised at each carbon of the polymer backbone. Rhodium mediated polymerisation of carbenes provides the means to prepare new materials with yet unknown properties. It also provides a valuable alternative to prepare practically identical polymers as in the desirable (but still unachievable) highly stereo-selective (co)polymerisation of functionalised olefins, representing the ‘holey-grail’ in world-wide TM polymerisation catalysis research. The mechanism and scope of this remarkable new discovery will be investigated and new, improved catalysts will be developed for the preparation of novel materials based on homo- and copolymerisation of a variety of carbene precursors. Copolymerisation of carbenes and other reactive monomers will also be investigated and the properties of all new materials will be investigated. In addition the team will try to uncover new reactions in which carbene insertion reactions play a central role. DFT calculations suggest that the transition state (TS) of the new carbene polymerisation reaction is very similar to the TS’s of a variety of carbonyl insertion reactions. Based on this analogy, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'INnovative oFfshore wInd techNologies In deep waTErs' under Horizon Europe.

assistant: **Concept**

The INFINITE project demonstrates a 4.8 MW floating offshore wind system at 100m water depth with two key technology innovations. The first is a disruptive and environment-friendly concrete tension leg platform anchored with an innovative tendon-based mooring system. The platform is designed to work with commercially available WTGs and is scalable, modular and self-installing, showing a vast potential for industrialisation. The second is an innovative aluminium dynamic cable design that is safer, lighter, cheaper and allows for more standardisation in O&M. The demonstrator makes use of a cost optimised O&M strategy that increases accessibility and turbine availability. Moreover, best practices for value co-creation with local stakeholders are applied leading to increased public acceptance of offshore wind developments and an improved Maritime Spatial Planning. The innovations result in an LCOE of 85.3 EUR/MWh at project end and set the path to achieve 43.3 EUR/MWh by 2030. An LCA of the technology innovations developed and an industrial roadmap bringing together innovation needs, supply chain readiness and policy frameworks to allow mass production and deployment complement the project activities.


**Keywords:** Floating offshore wind, tension leg platform, dynamic cable, demonstration, O&M, local stakeholders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Early Arabic Printing for the Arab Christians. Cultural Transfers between Eastern Europe and the Ottoman Near-East in the 18th century' (TYPARABIC).

assistant: **Innovation**

The main objective of the Project is to examine the circumstances and outcomes of printing in Arabic with Arabic type in the 18th century Greater Syria  (modern Syria and Lebanon), for Byzantine-rite and Catholic Arab Christians. It addresses the connections between Eastern Europe and the Arab Christians of the Ottoman Empire and the social progress brought by the print culture. It focuses on the transfer of printing technology from Moldavia and Wallachia (the Romanian Principalities) to the Ottoman provinces, for the benefit of the Arab Christians. It aims to yield a systematic, detailed inventory of the Arabic books printed in 1701-1800 in the Romanian Principalities and Greater Syria. Several other objectives are included: circumstances of the opening of Arabic presses in Ottoman-ruled provinces; the Antiochian Christians’ ties to Moldavia, Wallachia and Ukraine; the Western European printers’ support to Catholic Arabs; the role of printing in preserving Christian traditions and sanctioning the usage of Arabic in the Church; the contribution of printing to the Arab Renaissance (Nahḍa, 1820s). Presses to be surveyed: in Moldavia and Wallachia, Snagov (1701), Bucharest (1702) and Iași (1743-1747); in Greater Syria, Aleppo (1705-1711), Deyr el-Shuweyr (1734-1800) and Beirut (1750-1753). Other presses will be considered: Qozhaya (Lebanon), where a Book of Psalms was printed in 1610 in Syriac and Arabic (with Syriac type); and Istanbul, where a Turkish-language press worked after 1727 with Arabic type. The study corpus encloses forty-five books so far, with possible additions. They will be surveyed in terms of their content (Greek and Syriac sources, Arabic versions and their authors, variations, printing programmes) and their form (formatting, iconography, ornaments, art
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Quantitative extrapolation in ecotoxicology' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Reliable assessment of the ecological risks posed by chemicals is a fundamental component of European policies concerned with safe use of chemicals e.g. REACh, The Green Deal, and protection of ecosystem functioning and ecosystem services (Water Framework Directive). Chemical risk assessment typically involves extrapolation of effects observed in-vitro and in-vivo under laboratory conditions to predictions of effects at the ecosystem level. This is a very challenging task and current extrapolation models have limitations, notably due to a number of ecological processes that are disregarded by the models and the paucity of data for parameterisation and validation. QTOX will develop mechanistic knowledge and data efficient modelling tools to bridge the gap between standard toxicity data (typically acute effects of single chemicals) and ecologically relevant end points arising from chronic, time variable exposures to chemical mixtures. The results will be achieved through an interdisciplinary and intersectoral research and training program in which 10 doctoral candidates will characterise the mechanistic processes describing the successive events from exposure to ecosystem-level effects and develop models for extrapolation of adverse effects across levels of biological organisation under environmentally realistic conditions. Notably, the effects of chemical mixtures, dynamic exposure conditions and their interaction with climate change scenarios will be characterised in a series of mesocosm experiments at three sites in central and southern Europe. The mesocosm work will serve as a uniting training element and a rich source of data for testing and validating the modelling framework. QTOX will produce an open access toolbox for quantitative extrapolations in ecotoxicology a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhanced manufacturing systems for electro- welded wire mesh' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The aim of the project is to develop a pilot unit able to produce automatically metal meshes to be used in the industry of precast structures; the meshes will be already equipped with all required gaps and holes (doors, windows...) and wires of different section will be automatically placed in different points of the mesh, according to the load to be borne. Such a system addresses a clear need of this industrial sector; characteristics of ease and speed construction and economical convenience of precast structures do not match the present production process of metal electro-welded mesh (used in reinforced concrete) presenting a very low level of automation and a bad use of raw materials. In fact, for use in precast structures metal meshes must be manufactured considering all possible final gaps and holes of the final element (doors, windows...) as well as different load conditions of wires placed in different critical points of the mesh. Instead, meshes are manufactured either completely manually, or, starting from standard meshes, required openings are made manually and additional wire is welded in critical points, with significant loss of time and generation of waste and scraps. A significant effort will be required for the development of such a system, considering the very high degree of automation which will be introduced and the complex manufacturing phase which must be automated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Early detection and bio-control of mushroom pests and diseases in an Integrated Pest Management approach to comply with the European Directive 2009/128/EU' in the context of a Seventh Framework call.

assistant: **Objectives**

Cultivation of edible mushrooms Agaricus Bisporus in Europe is an economically valuable Industry that employs 50,000 employees with a production 965,000 tonnes and 1,300M Euros sales. Pests and diseases in this industry causes loses of  60M Euros related to Pest control. The main pest insects causing crop losses in Europe are Sciarid flies, whereas the main diseases are the fungus Verticillium, Mycogone, Dactilium and Tricoderma. Many chemicals are no longer approved for use, and with an increased demand for reduced pesticide use. Mushroom growers have an increased pressure to implement these alternatives on the basis of Regulation (EC) No 1107/2009 and Directive 2009/128/EC. Quick actions and IPM solutions are therefore urgently needed for mushroom growers as reported by their national associations in order to adapt to a stringent legislation to reduce pesticide use.The main aim of BIOMUSH project is to help European mushroom growers to implement IPM as part of their growing activities both to comply with the upcoming legislation and to reduce crop losses and production costs by efficiently manage pests and diseases. The main objectives: -Develop a tool for early detection of mushroom fungal diseases in situ to facilitate the control of competitor fungi and fungal diseases increasing productivity by 4%; -Provide novel biopesticides for the treatment of pests and diseases in mushroom; -Develop crop specific guidelines for Integrated Pest Management in mushroom crops in Europe; -Training to professional users and distributors.By facilitating the implementation of IPM techniques in mushroom, growers will be able to comply with the upcoming regulation which encourages natural pest control mechanisms reducing pesticides use per farm by at least 70% (3,472 Tons in Europe aft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-throughput hyperspectral imaging across the VIS-SWIR spectrum in a single device' (HYPERIA).

assistant: **Concept**

Building on the findings from our previous ERC PoC project, FLUO, the HYPERIA project will develop a hyperspectral imaging (HSI) camera that uses Fourier Transform (FT) interferometry to capture a detailed light spectrum across its wavelength range for each pixel in the 2D field-of-vision. This constitutes a novel detection approach that will dramatically expand the wavelength range and sensitivity at low light intensities for HSI camera. With its VIS-SWIR range (400-1700nm), the camera will be able to capture visible features, key SWIR ?fingerprints? for physiochemical analysis and fluorescence signals from non-visible features. The HYPERIA camera will have a wide range of possible applications and we will demonstrate it to TRL6 in monitoring of food freshness and composition, plastic waste separation, analysis of fine arts and remote sensing/inspection of building materials. Current HSI cameras are limited to narrow wavelength ranges, so these forms of applications require two or more costly devices and difficult and time-consuming integration of different data sources. The HYPERIA camera will accomplish the task in one device yielding a single hyperspectral datacube at a hitherto inaccessible level of sensitivity and at a lower total cost. In parallel to this, we will obtain market, competitor, and regulatory intelligence to establish our business model, price- and cost model and potential positioning within the market for our prioritised application area, food production and safety monitoring. This will place us in an advantageous position to advance the HYPERIA camera to TRL9 and market readiness after the end of the proposed project.


**Keywords:** Hyperspectral imaging. Spectral imaging. Interferometers. Fourier-transform spectroscopy. FTIR. Food freshness and c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cold Collisions and the Pathways Toward Life in Interstellar Space' (ASTROLAB) under Seventh Framework.

assistant: **Objectives**

Modern telescopes like Herschel and ALMA open up a new window into molecular astrophysics to investigate a surprisingly rich chemistry that operates even at low densities and low temperatures. Observations with these instruments have the potential of unraveling key questions of astrobiology, like the accumulation of water and pre-biotic organic molecules on (exo)planets from asteroids and comets. Hand-in-hand with the heightened observational activities comes a strong demand for a thorough understanding of the molecular formation mechanisms. The vast majority of interstellar molecules are formed in ion-neutral reactions that remain efficient even at low temperatures. Unfortunately, the unusual nature of these processes under terrestrial conditions makes their laboratory study extremely difficult.To address these issues, I propose to build a versatile merged beams setup for laboratory studies of ion-neutral collisions at the Cryogenic Storage Ring (CSR), the most ambitious of the next-generation storage devices under development worldwide. With this experimental setup, I will make use of a low-temperature and low-density environment that is ideal to simulate the conditions prevailing in interstellar space. The cryogenic surrounding, in combination with laser-generated ground state atom beams, will allow me to perform precise energy-resolved rate coefficient measurements for reactions between cold molecular ions (like, e.g., H2+, H3+, HCO+, CH2+, CH3+, etc.) and neutral atoms (H, D, C or O) in order to shed light on long-standing problems of astrochemistry and the formation of organic molecules in space.With the large variability of the collision energy (corresponding to 40-40000 K), I will be able to provide data that are crucial for the interpretation of molecular obser
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A Revolutionary Tech for Exceptionally Efficient Natural  Muscle Tissue Growth in Cultivated Meat Applications'.

assistant: **Objectives**

Whilst meat demand is expected to double by 2050, consumption needs to drop by 50% to reduce greenhouse gases and preserve land. Cultivated meat - meat products manufactured through the harvesting and proliferation of animal cells - offers a feasible alternative, supplying animal protein at minimal environmental costs. However, the industry faces significant challenges linked to production costs, ability to scale-up, and final product quality. The main technical bottlenecks arise from the need to continuously source cells from live animals, and inefficient differentiation and maturation processes, that fail to achieve nutritional and organoleptic characteristics to satisfy consumers. Harnessing unique expertise on muscle cultivation, ProFuse has developed the first spontaneously immortalized and stable myoblast cell line (bovine) with remarkable proficiency in both muscle tissue proliferation and differentiation. Secondly, ProFuse has formulated a media supplement capable of driving the highly effective fusion and maturation into contractile muscle, successfully mimicking natural muscle development. After receiving the licensing of the patent protecting the discovery and the incorporation of our start-up for boosting development and commercialization, our team has established strong relationships with worldwide leading cultivated meat producers and suppliers, developing initial supplement formulations for different 2D and 3D applications. Through this project, we aim at optimizing our combined cell-line + supplement solution for scale-up enabling 3D production techniques up to reaching the validation in relevant environment with at least 3 potential clients while preparing the certification dossier, thus bringing our combined cell-line + supplement solution to TRL6. Pro