RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CodeSphere - Discovering Therapeutic Nanoparticles by Molecular Encoding' to be submitted under Horizon 2020.

assistant: **Abstract**

There is currently no high-throughput method to efficiently identify and optimize nanoparticle delivery of therapeutic relevant cargo such as drugs or mRNA before progression through costly clinical development.  This is in stark contrast to the situation for small molecules and antibodies, where screening technologies such as high-throughput small molecule screening and phage display in the last decades have proven very successful to aid and drive drug discovery and development.Our project ‘CodeSphere’ seeks to develop a method for DNA-tagging of nanoparticles to efficiently optimize nanoparticles on several parameters in parallel from libraries which - in time - will be at least 1.000-10.000 larger than the capability of current state-of-the-art screening methods. The project will initially work towards the generation of a library of > 1.000 different T cell targeted liposomal nanoparticles containing mRNA encoding anti-cancer proteins.This library of DNA-tagged nanoparticles will be screened in “one-pot” in human blood to identify nanoparticles with optimal characteristics to efficiently deliver mRNA to specific cell populations.Through such a technology, one could gain knowledge on which particle design is most optimal including stability in blood, ‘stealth’ evasion of the immune system, optimal systemic circulation time, efficiency in reaching the target tissue (e.g. cancer lesion) and efficiency in delivering the drug or other cargo. The technology can be applied to whole blood preparations, primary cells, cell lines, and even as in vivo screening in whole organisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Market Selection, Frictions, and the Information Content of Prices' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

This project studies information aggregation in multiple-linked auction markets with large numbers of goods and bidders. Past work assumes bidders trade in a single, centralized, frictionless auction market. Instead, I study bidders with unit demand who decide to purchase one of many possible goods which are on auction in distinct markets. The goods traded in each market are identical, common-value objects and the price is determined by a uniform-price auction. Bidders receive imperfect signals about the state of the world and select to bid in one of the auction markets. The markets differ in institutional structure and therefore frictions. Market frictions result from imperfect competition, government interventions, informational frictions, and preference heterogeneity. All such frictions render the gains from trade uncertain.I address the following questions: How do market frictions affect information aggregation if bidders can strategically choose between markets? What are the mechanisms through which market imperfections disrupt information aggregation? Which market’s price is a better statistic for market participants’ information? Which market attracts better-informed bidders? Do prices aggregate beliefs more accurately in good times or in bad?Initial findings suggest that the proposed framework can prove particularly fruitful in addressing these questions. Specifically, I show if the gains from trade are uncertain in even one market, then prices do not aggregate information in any of the markets. In contrast, if all markets are frictionless, then the price in each market aggregates information. These findings are driven by how bidders self-select across markets: Better-informed bidders select frictional markets while uninformed, pessimistic bidders select the saf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'A laser-cooled molecular fountain to measure the electron EDM'.

assistant: **Innovation**

I propose to build an instrument that cools YbF molecules to microK temperature using laser light, and throws them up as a fountain in free fall.  This will be used to detect CP-violating elementary particle interactions that caused our universe to evolve an excess of matter over antimatter  These interactions cause the charge distribution of the electron to be slightly non-spherical and it is this property, the permanent electric dipole moment (EDM), that the ultracold molecules will sense.Laser cooling of any molecule is very new, with first results emerging from a few laboratories including mine. Developing a fountain of molecules will be a major advance in the state of the art.  As well as being the key to the new EDM instrument, this will be important in its own right because ultracold molecules have major applications in chemistry, quantum information processing and metrology.In the fountain, the electron spin of each molecule will be polarized. On applying a perpendicular electric field, the spins will precess in proportion to the EDM.  At present the (warm) YbF molecules in my lab precess for only 1ms. This gives us world-leading sensitivity, but has not been sufficient to detect the CP-violating forces being sought. The fountain however will achieve precession times of almost a second, giving over 1000x more rotation.  The increase in sensitivity should reveal a clear EDM, providing information about the fundamental laws of physics, and the important CP-violating physics of the early universe, which is currently not understood.By advancing the preparation of ultracold molecules, this project will address a key question in particle physics and cosmology: the nature of CP-violating physics beyond the standard model. The approach is radically different from standa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Palladium anchored Halide Perovskites for Solar-driven Diphenyl Carbonate Synthesis' (SolarCar).

assistant: **Concept**

Global CO2 emission dominated by burning fossil fuels is resulting in serious societal and environmental issues. To reduce CO2 emission, it is ultimately needed to move away from the reliance on fossil fuels and develop new processes and technologies for CO2 capture and transformation to value-added chemical and products. This project aims to develop and validate an innovative concept for solar energy-driven diphenyl carbonate— essential monomer for polycarbonate—synthesis by coupling CO2 reduction and phenol oxidation half reactions over palladium single atom supported bismuth-based porous halide perovskite photocatalyst. The proposal consists of key scientific and technological targets and objectives; i) modulation of band structure and creation of defects sites on morphology-controlled halide perovskites for anchoring of palladium single atom sites, which will result in a new class of hybrid materials, ii) demonstration of the proof of concept of CO2 reduction and phenol oxidation half-reactions, and the combination of their intermediates to form diphenyl carbonate over hybrid photocatalyst, which is an untouched research territory and has great scientific and technological potentials, iii) exploration and gaining insights about reaction mechanism by using state-of-the-art spectroscopic methods and theoretical predictions. This high-risk/high-gain project is expected to have far-reaching scientific, economic, technological, and societal impacts.


**Keywords:** solar-driven photocatalyst,  single metal atom,  halide perovskite, diphenyl carbonate production,  coupling of photo-redox radical intermediates
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A network slice for every service' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

5G!Pagoda represents the next evolution step in softwarized networks as supported by NFV, SDN and aimed at by the 5G network evolution. The top objectives of 5G!Pagoda are i) the development of a scalable 5G slicing architecture towards supporting specialized network slices composed on multi-vendor network functions, through the development of ii) a scalable network slice management and orchestration framework for distributed, edge dominated network infrastructures, and convergent software functionality for iii) lightweight control plane and iv) data plane programmability and their integration, customization, composition and run-time management towards different markets in Europe and Japan. 5G!Pagoda will develop a coherent architecture enabling research and standardization coordination between Europe and Japan. The proposed developments integrate with a common SDN/NFV based architecture and will additionally provide punctual and highly important developments of the software network architecture. The developments address the next steps of the evolution beyond the immediate NFV standardization and developments, enabling the graceful integration within end-to-end network slices of various highly customized software components, remotely controlling the data path, with specific network function flexibility and network function placement support and easy to manage through a convergent set of scalable orchestration APIs. Besides the technological aspects, 5G!Pagoda will develop a coherent proof of concept with two playground nodes, one in Japan and one in Europe, using a uniform network orchestration and a set of in-slice software features enabling the transparent exchange of knowledge and practical implemented components for dynamic deployment and execution of virtual networ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improving engine performance and efficiency by minimisation of knock probability (MINKNOCK)' under Fifth Framework.

assistant: **Concept**

Objectives and problems to be solved:To date, the optimisation of existing engines and the development of new engine concepts like DGI, down-sizing, turbo charging or CAI is still a challenge for engine developers considering high loads over the entire speed range. This is mostly due to the knocking phenomenon, which is still not sufficiently understood. Engine knock is the limiting factor for increasing engine efficiency and is also responsible for increased emissions at high loads over the entire speed range. Describing and even predicting knocking is a tedious task, requiring detailed knowledge of all the processes occurring in the combustion chamber. The objective of the proposed project is to provide a better understanding of how engine knock is initiated and influenced by fuel and engine parameters. The results of the project complement current databases, instrumentation and simulation tools and empower development engineers to further improve engine performance and efficiency, to reduce engine pollutant and GHG emissions simultaneously and to reduce time and costs in the development process.Description of the work:Understanding the engine knock phenomenon is a mandatory but also tedious task as knock occurs locally in the cylinder and depends on many features such as engine geometry, flame propagation, wall temperatures and ignition timing. However, insight into the knock phenomenon can be obtained by means of CFD simulation and detailed experiments. Therefore, advanced and very promising measurement techniques are being employed and new simulation tools are being developed and validated in this project. Major technical objectives are to perform advanced experiments in both fired research and fired production engines of gasoline type with only minor modifications
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Fire events risk assessment through remote sensing', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The project submitted attempts at demonstrating the usefulness and cost-effectiveness of Earth Observation satellite data in the assessment of forest fire risk over the Mediterranean area for better organization and coordination of air intervenion during forest fire control and extinction operations by National Civil Protection bodies. A prototype" information system will be developed, containing enhanced earth observation products, to be integrated to the Civil Protection decision-making process. In the Mediterranean Countries millions of hectars of forest areas burned in the last years. This causes huge human life and property losses and strong environmental degradation. The operational problems tackled in the project are the following. The Civl Protections have the need to optimise the surveillance operations strategy of air means available for forest fire fighting and extinction, using reliable indications about the maximum fire risk areas. Up to now the only indications are provided by a fire risk index based on weather variables measured mainly at point locations. The FIERS project has the aim to assess the operational feasibility of computation, dissemination and use of a real time forest fire risk index generated from daily AVHRR data (Vegetation Indexes and Surface Temperature ) at 1x1 km resolution. The methodology at hand is quite consolidated, having being tested in many research activities and in particular in the EC MINERVE project (IV RTD Framework Programme-Environment and Climate) where three of the participants to the present proposal were present. The measurable obiectives and deliverables of the system will be: - preoperational systems to generate and disseminate to Civil ProtectionNational organizations a daily forest fire risk index derived from AV
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'IAPP on novel genetic and phenotypic markers of Parkinson's disease and Essential Tremor' to be submitted under Seventh Framework.

assistant: **Abstract**

Copy number variations (CNV) are ubiquitously found throughout in the human genome. Their role in monogenic as well as multifactorial disorders as potential disease modifier is more and more stressed (Abecasis et al., 2007). In order to investigate the role of CNV in Parkinson’s disease (PD) and Essential Tremor (ET), two frequent neurological diseases, MARKMD brings together the unique expertises of deCODE genetics (Iceland) and University of Tübingen (Germany). On the one hand, deCODE genetics will contribute and transfer its unique genetic, epidemiologic and biostatistical expertise. The University of Tübingen, on the other hand, will contribute and transfer neuroimaging and clinical expertise in regard to PD and ET. Co-operation and transfer of knowledge is dedicated to the establishment of new tools for the detection of disease associated CNV and clinical markers in patients as well as healthy at-risk groups. Thus, we anticipate to come up with new neuroimaging/clinical and genetic markers relevant to the etiology and progression of PD and ET. Transfer of knowledge will be implemented through secondments, recruitments, and meetings. There will be a structured exchange of principle investigators from both partners at project milestones facilitating the training of newly recruited team members. All recruited project members will have workpackages at either partner which allows to disseminate project outcomes easily.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Magnetic Scaffolds for in vivo Tissue Engineering'.

assistant: **Objectives**

The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system.   The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. . .     Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but nowadays there is no way to grant that tissue regeneration take place in the pathological site. The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests [Ref. Nanomedicine roadmap].   The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds – magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. The magnetic moment of the scaffolds enables them with a fascinating possibility of being continuously controlled and reloaded from external supervising center with all needed scaffold materials and various active factors (AF).  Such a magnetic scaffold can be imagined as a fixed “station” that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'OBesogenic Endocrine disrupting chemicals: LInking prenatal eXposure to the development of obesity later in life' to be submitted under Seventh Framework.

assistant: **Abstract**

The incidence of childhood obesity has reached ‘epidemic’ proportions globally and there is an urgent need to increase our understanding of the impact of food contaminants on obesity development. The OBELIX project will examine the hypothesis that prenatal exposure to endocrine disrupting compounds (EDCs) in food plays a role in the development of obesity later in life. OBELIX proposes a multidisciplinary approach that combines epidemiology, neonatology, endocrinology, toxicology, analytical chemistry and risk assessment to address the objectives of the project: 1) To assess prenatal exposure in humans to major classes of EDCs in food identified as potential inducers of obesity (i.e. dioxins, non- and dioxin-like polychlorinated biphenyls, brominated flame retardants, phthalates and perfluorinated alkyl acids) using mother-child cohorts from four European regions with different food contaminant exposure patterns; 2) To relate early life exposure to EDCs with clinical markers, novel biomarkers and health effect data related to obesity; 3) To perform hazard characterization of in utero exposure to EDCs for the development of obesity later in life, using dose-response analysis in a rodent model; 4) To determine mechanisms of action of obesogenic EDCs on developmental programming with genomics and epigenetic analysis in in vivo and in vitro models; and, 5) to perform risk assessment of prenatal exposure to obesogenic EDCs in food, by integrating maternal exposure through food, contaminant exposure and health effect data in children, and hazard data. The outcomes of OBELIX are of particular relevance to the Work Programme, as the proposed project will generate new knowledge about prenatal exposure to major classes of EDCs in food that are potential inducers of obesity and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enhancing health system quality of care in pregnancy and childbirth based on locally generated evidence and adapted interventions' under Fifth Framework.

assistant: **Concept**

We develop a health systems research methodology to identify locally appropriate and accepted strategies and interventions for improved maternity care, based on a pre-tested set of indicators for monitoring and evaluating performance and interaction of service components. Specific sets of interventions are developed jointly with health managers in 3 African study sites. Key areas are content of maternity care routines and underlying concepts, quality of care, staff motivation and performance and organisational / political prerequisites for sustainable management. Selected interventions are implemented through site-specific action plans and follow the steps: Health service analysis, priority setting and identification of appropriate interventions; implementation and evaluation; comparative analysis and documentation of research process and results. The organisational preconditions for sustainability are identified and promoted.