RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A zebrafish model of pancreatic neuroendocrine tumor to test resistance to antiangiogenic compounds' under Seventh Framework.

assistant: **Concept**

Neuroendocrine tumours (NETs) consist of a range of rare neoplasms that may arise from any (neuro)endocrine cell situated in any part of the human body. Despite the recent approval of two new drugs (sunitinib and everolimus) for pancreatic NETs, innate resistance is frequently encountered in these tumours and patients showing a response invariably relapse due to acquisition of resistance. Moreover, while new data are being generated, including publication of the exome sequence of pancreatic neuroendocrine tumours, the mechanisms of resistance to angiogenesis compounds have not yet been completely elucidated.Data from animal models are scarce about resistance mechanisms to antiantiogenesis compounds in NETs. The zebrafish has recently emerged as an invaluable model system for the study of human cancers.Our main aim is to establish a new zebrafish model for neuroendocrine tumours that can be used to investigate resistance mechanisms to antiantiogenesis compounds. The main hypothesis of our proposal is that we will be able to develop an autochthonous transgenic model of pancreatic neuroendocrine tumours in zebrafish and combine this with the already established kdrl-eGFP transgenic zebrafish line with blood vessels expressing a green fluorescent protein.The objectives of the study are:1.To engineer an autochthonous transgenic zebrafish model of neuroendocrine pancreatic tumours.2.Couple the above model with zebrafish possessing GFP-marked blood vessels.3.Test the activity of known antiantiogenesis compounds such as sunitinib and novel ones in the model generated.4.To establish lines of fishes resistant to antiantiogenesis drugs.Angiogenesis being a complex and dynamic process, the in vivo study of acquired resistance in tumours and accompanying alterations in tumour vascul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Intensity Correlations for Stars' (IC4Stars).

assistant: **Concept**

The pioneering experiments of intensity correlations by Hanbury-Brown and Twiss more than 50 years ago not only allowed to measure the angular diameter of many bright stars, but it also motivated Roy Glauber to develop his quantum formalism of photon statistics. The advent of direct optical interferences of light collected by different telescopes developed in the beginning of the 70s, with superior performances in terms of signal to noise ratio and correspondingly reduced required observation time put an end to these first attempts of intensity correlation imaging for astrophysics. State of the art optical interference imaging is however limited by accessible baselines and the required mechanical precision for optical delay lines are limited in particular due to atmospheric fluctuations and at short wavelengths. In IC4Stars we will use modern photon counting techniques to perform quantum optics measurements and probe quantum systems in astrophysics. A first target will be a quantum degenerate Fermi gaz of electrons (a white dwarf) whose angular diameter is out of reach for direct optical imaging techniques. A second goal will be the search for quantum sources of radiation by looking for random lasing in astrophysics, to be detected by second order photon correlation.


**Keywords:** Hanburry-Brown and Twiss, intensity correlations, random lasing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Assessing the conditions for a region-wide TRANsition to SOLAR energy in the Mediterranean' to be submitted under Seventh Framework.

assistant: **Abstract**

North Africa and the Middle East have the largest solar energy potential in the world (World Bank 2010). Developing solar energy is capital intensive, and the Mediterranean region is not rich in private and public capitals. This means that the transition to solar energy has high initial costs that Mediterranean countries cannot afford alone. Experts and political scientists have been working on how to scale-up solar energy investment to targeted countries (scaling-up problem). However, official reports showed that the shift to solar energy is taking place in very few Mediterranean countries rather than within the region as a whole (UNEP 2012). Surprisingly, no specific attention is being devoted to the problem of ‘how a region-wide transition to solar energy can be achieved in the Mediterranean’ (widening problem). The TRANSOLAR project is tackling the ‘widening problem’ directly on the ground. Drawing on comparative country-case studies in five selected countries (Morocco, Algeria, Tunisia, Egypt and Turkey) between 1994 and 2012, This project will offer an in-depth study of: (a) the regulatory frameworks and existing financing mechanisms in the Mediterranean region; (b) the limits and potential of Euro-Med renewable energy cooperation; (c) and the state of public participation (i.e. civil society at large) and transfer of know-how in the field of solar energy within the Mediterranean region. To gather evidence, this project will employ the following methods: semi-structured interviews with policy makers, questionnaires and a participatory assessment with public/private decision-makers. As a result of this, this project will build knowledge on how to facilitate a region-wide transition to solar energy in the Mediterranean. KEYWORDS: Socio-Technical Transitions in Devel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Intrinsic and extrinsic determinants of neuronal identity' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Neuronal diversity determines the variety of circuits that can be formed and thus sets the framework for an animals behavioural repertoire. During development, distinct neuronal types emerge from interactions between cell-intrinsic processes and cell-extrinsic processes. In the brain, untangling how intrinsic and extrinsic processes contribute to neuronal identity has been difficult, as neurons are highly interconnected and heterogeneous cells with distinct and dynamic sensitivities to environmental signals. In such conditions, high temporal single-cell resolution approaches are required to parse out the drivers of cell-type differentiation. The mouse neocortex is an ideal model to tease out drivers of differentiation: radially, cell-intrinsic genetic mechanisms drive the generation of successive neuron types across cortical layers; tangentially, cell-extrinsic processes are critical to drive differentiation via synaptic input across cortical areas. Here, using the developing neocortex as a model system, I propose to identify how cell-intrinsic and -extrinsic processes interact to define distinct neuron identities by characterizing: 1. emergence of area-specific neuronal and progenitor identities using FlashTag fate mapping and single-cell RNA sequencing (Work Package (WP) 1) 2. plasticity of area-specific neuronal states in response to genetic manipulation, transplantation or input/activity manipulation (WP2) 3. spatial context-independent components of neuron identity, by uncovering core molecular and circuit states in vitro (WP3) 4. postnatal experience-dependent controls over neuronal identity, using the precocial rodent Acomys as a new model to study the role of early brain-world interactions (WP4). Together, these experiments aim to identify the molecular determin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'European Network for Cyber-security'.

assistant: **Objectives**

The European Network for Cybersecurity (NECS) was formed in response to the increased need of highly qualified experts able to cope with all the aspects of the European cybersecurity strategy  that is currently under implementation.There is indeed an evident need and opportunity to grow a new generation of young researchers able to answer this demand for expertize, trained to the changing nature of the challenges to be faced. These challenges include evolvable threats and new technological means to exploit network and information security vulnerabilities of cyber systems that have eventually consequences in the physical world. Starting from these considerations, the European Commission proposed the “DIRECTIVE OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL concerning measures to ensure a high common level of network and information security across the Union” . This directive proposal, on the one hand, recognizes the relevance for the European economy of cybersecurity, on the other one, poses the regulatory basis for achieving a common level of cybersecurity preparedness among the main European public/private stakeholders. This 4-year project for a cybersecurity research and training network aims at contributing to answer this increased demand of human expertise in the field. The project; by fosters ing a multi-sectorial/disciplinary approach that is clearly necessary for tackling all cybersecurity aspects - as also recognized by the European Network and Information Security (NIS) platform recently established by the EU to contribute to the strategy that is firmly based on a public/private cooperation.Being cybersecurity inherently multi-sectorial, NECS has participants (beneficiaries and partners) both from the academic sector (7) and non-academic one (5). In the NECS res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Marine INspection rObotic Assistant System' (MINOAS) targeting Seventh Framework.

assistant: **Abstract**

The increasing competitiveness in marine operations creates a need for new system concepts that introduce high technology value added products, facilitate the processes involved and minimize the downtimes. The need, thus, lies not only in incorporating the technological means so far available, but in changing the way the corresponding authorities stand against the challenges at hand.MINOAS project proposes reengineering of the overall vessel-inspection methodology, by introducing an innovative system concept that incorporates state of the art technologies, but at the same time formulating a new standardization of the overall inspection process. Through holistic approach, MINOAS proposes the development of a new infrastructure that substitutes human personnel by high locomotion enabled robots and ‘teleports’ the human inspector from the vessel’s hold to a control room with virtual reality properties. The human’s perceptual abilities are enhanced through the utilization of high resolution tools (eg sensors) and are augmented through the parallel processing property provided by MINOAS. Following the centralized control scheme adopted in similar distributed control methodologies (SCADA), the number and the sequence of the tasks required is rearranged and the overall inspection procedure is brought in alignment with the current tendency adopted in similar inspection, exploration and surveillance tasks.The proposed innovative system concept, considers the assembly of a robot fleet with advanced locomotion abilities and sets of tools that are dedicated to the tasks attached to the inspection process, the development of control techniques and algorithms that provide a semi-autonomous nature to the operation of the robot-fleet and a hierarchical controller that realize the virtu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Digital imaging techniques for surface quality assessment in manufacturing industry' (DIGIMAN), addressing dissemination and exploitation.

assistant: **Impact**

Project's actual outcome (actual status at mid term):Prototype systems for the fixed camera system and the robot guided strain analysis system together with a prototype marking facility have been build and are in the stage of industrial testing. A database for aesthetic defects is has been set up and filled with data. A prototype of an aesthetic defects device has been build and integrated into the system. The DIGIMAN common user interface developed in this project allows easy monitoring and interpretation of the quality of the measured sheet metal parts.Objectives and content Sheet metal forming is one of the most efficient and most economic production processes for mass production of several components. However, sheet metal stamping of complex components is also characterised by several failure modes like wrinkling and puckering, cracking and necking as well as surface defects. Avoiding rejects requires quality control in the production line and the evaluation of the collected data to control previous process steps. The surface geometry measurement and aesthetic defect detection of stamped parts in the manufacturing process shall be performed with digital image processing techniques combined with automated strain analyses. The main problems using these techniques are the large dimensions of the formed parts combined with very small features respectively errors. In addition the time available for the quality control of each part is very short within the scope of the mass production. Therefore, the objective of the project is the development of an automatic optical measuring system for the assessment of sheet metal components in terms of shape accuracy, strain and surface quality. To achieve this goal, the system has to analyse the surface of the component. Based on the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of technology to measure concentrations of water in heavy fuel oil' (1994-1998).

assistant: **Concept**

This project will develop the technology employed by an existing fluid level sensor to produce a novel, relatively inexpensive method of measuring the concentration of water in heavy diesel fuel oil. This will enable large diesel engine manufacturers to optimise the removal of nitrogen oxides from exhaust fumes by monitoring the amount of water added to the fuel for this purpose. The present device can determine which of up to three fluids of fixed concentration is present in its flow chamber using an Infra-red interrogation technique. The research programme will expand and develop this process to the point where water in oil concentration can be measured to a satisfactory accuracy. The scientific innovation will incorporate a coherent light source and a position sensitive detection and analysis system. It is anticipated that the subsequently developed instrumentation will find many applications in other areas of industry where concentration levels must be monitored and controlled.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A novel class of antibiotics to combat Antimicrobial Resistance' (OMN6), addressing dissemination and exploitation.

assistant: **Impact**

We are in living in times where the efficacy of antibiotics is no longer guaranteed. Despite the urgent need to mitigate the spread of antimicrobial resistance (AMR), very few antibiotics are being developed. AMR management costs €1.5 B and causes 33,000 deaths each year in the EU. We at Omnix are determined to change lives and repopulate drug development pipelines by demonstrating clinical efficacy of a novel class of antibiotics. We have made potent antimicrobial peptides found in nature druggable, by hampering their biodegradability using our proprietary platform technology.  The results are highly selective, life-saving therapies which are safe to humans. These bioengineered peptides constitute a new class of antibiotics due to their unique mechanism of action, which remains effective regardless of underlying resistance patterns.We intend to solve the most urgent clinical need in infectious disease management by targeting drug resistant pathogens topping the WHO’s priority list. The project will demonstrate clinical safety and efficacy in treating A. baunmannii infections. This top-most critical pathogen exerts a mortality rate of ~40%. We have already successfully established a preclinical proof of concept for our lead candidate. Commercialisation is planned to take place with a partner from the pharma sector. The deal size is predicted to be €150-250 and conservative estimates on sales forecast revenues around €50 M five years after launch. Revenues will be reinvested into developing antibiotics for other critical pathogens and into scaling Omnix to over 150 employees.Our approach has the potential to make a significant impact on the global AMR challenge, as we base our drug design on peptides that have remained effective for millions of years, demonstrating a low
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'MULTILEVEL ADVANCED RAILWAYS CONFLICT RESOLUTION & OPERATION CONTROL'.

assistant: **Innovation**

Traffic conflict detection and resolution on EU railway and metro networks is the focus of MARCO. The project will develop tools, algorithms and technologies for this purpose at top high traffic and mainline supervisory level, the medium level of high traffic areas with complex junctions or stations, as well as local lines, and the end line situation on underground services. Central operators at all three levels will access the conflict resolution system via a user-friendly man/machine interface. Planned for testing in three Member States, the system is expected to upgrade the quality of transport, with better passenger information and much reduced delays.The purpose of the MARCO project is to develop a set of tools, algorithms and technologies for the Conflict Detection and Resolution in a wide range of real time applications within Railways and Metros networks. Referring to a multilayered Supervision System for Traffic Control, the project will improve the Conflict Resolution Sub-System (CRS) for:- Top level of Railways System: Global Area Network (GAN) which includes many High Traffic Area (HTA) and Main Lines (ML) in between. The GAN will be considered both at the Country and at the Subnetwork level.- Medium level of Railways System: High Traffic Area which includes complex Junctions, Stations, local lines.- Underground level, developed for its most complex operative situation(end line)For each level of the above hierarchy, an appropriate man-machine interface will be developed to allow the central operators to interact with the CRS in an immediate and friendly way. The CRS will be verified on well defined contexts in Germany, Italy, Belgium and Finland and in particular:- Global Area Network, applied to Germany and Belgium network, in laboratory through Simulator T