RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Macroencapsulated Porcine Pancreatic Islets to cure Diabetes Mellitus type 1/2' (XENOISLET) under Seventh Framework.

assistant: **Objectives**

During the last five years, within the EU FP6 Integrated Project XENOME (LSHB-CT-2006-037377), we have convincingly demonstrated in primates that a complete control of induced type 1 diabetes is routinely obtained for 6/8 months after transplantation of subcutaneous alginate macroencapsulated porcine islets xenograft without the use of any immunosuppression. In order to improve the function of pig islets, we have produced with AVANTEA a transgenic pig expressing GLP-1 at the level of the pig islets. In fact, GLP1 is not only able to (i) increase the insulin gene expression and insulin biosynthesis, but also to (ii) induce the replication of islet cells and promotes islet-cell neogenesis and (iii) protect islets cells from apoptosis. GLP-1 has already demonstrated its in vivo potential to improve insulin secretion in subjects with impaired glucose tolerance and type 2 diabetes. New vectors (GLP1/M3Rr) containing both GLP1 sequence and muscarinic receptor mutation  (M3R) will also be tested.  The main objectives of this four-year project will therefore be (1) to evaluate in vitro the effect of GLP1/M3R transgene expression in pig islets after hyperglycaemic challenge; (2) to continue to produce double transgenic pigs specifically  expressing GLP-1/M3R in pig islets under  insulin promoter, and (3) finally to test these modified pig islets in our well characterized pig-to-diabetic primates model in vivo. However, in order to use islets from newborn unmodified or transgenic pigs, we will also set up (4) the pig islets isolation and cell maturation technique for Neonates Pancreatic Pig Cluster cells since neonates pig islets have prolonged survival and would also render possible the use of Designed Pathogen Free (DPF) neonates pigs which will represent a key point to reach c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Probing the angular dynamics of biological systems with the optical torque wrench' (BIOTORQUE).

assistant: **Innovation**

The ability to apply forces to single molecules and bio-polymers has fundamentally changed the way we can interact with and understand biological systems. Yet, for many cellular mechanisms, it is rather the torque that is the relevant physical parameter. Excitingly, novel single-molecule techniques that utilize this parameter are now poised to contribute to novel discoveries.  Here, I will study the angular dynamical behavior and response to external torque of biological systems at the molecular and cellular levels using the new optical torque wrench that I recently developed.In a first research line, I will unravel the angular dynamics of the e.coli flagellar motor, a complex and powerful rotary nano-motor that rotates the flagellum in order to propel the bacterium forwards. I will quantitatively study different aspects of torque generation of the motor, aiming to connect evolutionary, dynamical, and structural principles. In a second research line, I will develop an in-vivo manipulation technique based on the transfer of optical torque and force onto novel nano-fabricated particles. This new scanning method will allow me to map physical properties such as the local viscosity  inside living cells and the spatial organization and topography of internal membranes, thereby expanding the capabilities of existing techniques towards in-vivo and ultra-low force scanning imaging.This project is founded on a multidisciplinary approach in which fundamental optics, novel nanoparticle fabrication, and molecular and cellular biology are integrated. It has the potential to answer biophysical questions that have challenged the field for over two decades and to impact fields ranging from single-molecule biophysics to scanning-probe microscopy and nanorheology, provided ERC funding is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Soil C cycling and ecosystem processes: effects of plant diversity, plant community composition, N deposition and herbivory on soil C storage dynamics' (2002-2006).

assistant: **Innovation**

Human actions are causing (1) declines in biodiversity, (2) increases in atmospheric CO2 and (3) increases in N deposition. The interactive effects of these factors and their consequences on ecosystem processes are unknown, though they play a critical role in global soil C storage dynamics. Recent data from well-replicated, long-term studies on the effects of plant diversity on both ecosystem productivity and carbon sequestration show that enhanced biomass accumulation is positively related to plant diversity. Moreover, preliminary work suggests that plant species composition may be as important as species diversity in affecting soil C sequestration. Finally, biotic factors such as herbivory through indirect effects on plant roots, affect long-term fate of C and below-ground processes. Hence, the present project aims to address the effects of (1) plant diversity, (2) plant community composition, (3) N deposition, and (4) herbivory on soil C storage dynamics. The study will make use of a well-replicated, long-term study design that has been established in 1994 at Cedar Creek, Minnesota, US, as well as glasshouse experiments using isotopic techniques in the UK. Soil and plant material will be measured for C and N. Data on plant productivity, N mineralization rat es, C:N ratios, and nitrogen use efficiency will be collected according to different treatments. The research project is the first, to our knowledge, to test the effects of varying biodiversity, species functional composition and N fertilization on soil C storage dynamics at the ecosystem-scale being part of a well-replicated, long-term factorial grassland biodiversity experiment. Therefore, the overall results of the study will contribute to the important ongoing scientific research, which focuses on the effects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Neocortical Daisy Architectures and Graphical Models for context-dependent Processing', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The neocortex of higher mammals like carnivores and primates has a lattice-like network of local circuits embedded within inter-aerial connections, which together form the 'daisy architecture' (DA). Our hypothesis is that the DA supports self-organized, context-dependent processing. Data derived from quantitative neuroanatomy and high spatio-temporal resolution imaging of cortical activity will be used to test theoretical predictions about the possible mechanisms and function of the DA. Understanding this architecture, and its computation will have two major benefits: Firstly, it will contribute to our understanding of how the brain reasons, and so will have important implications for mental health. Secondly, if the structure and dynamics of the DA could be reversing engineered it would be a major advance in Information Technology by offering novel methods for scalable, distributed, autonomous computation.We explore two candidate models of computation on the DA: graphical models such as Bayesian Networks and Factor Graphs that factor complicated global functions into a product of simpler ones and Dynamic Link Architectures that encode and recognize objects by dynamic composition of neuronal interactions. We implement these computational styles in hybrid analog/digital CMOS VLSI circuits, which contribute to the 'End of Moore's Law Problem' by demonstrating how existing CMOS technology could be more efficiently deployed than in clocked digital systems. We explore the semantic nature of the biological computations by imaging the activity of cortical neurons as they respond to perceptually significant stimuli and evaluate our hypotheses about the DA by constructing object recognition systems that extract meaningful invariances from examples. These results would considerabl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'VALORISATION AND OPTIMIZATION OF NOVEL FIRST-IN CLASS SUCCINATE-DEPLETING THERAPIES'.

assistant: **Innovation**

SUCCIPRO is a spin-off company from Pere Virgili Health Institute and Rovira Virgili University.  It is an early-stage drug development company focused on therapies able to modulate the succinate-SUCNR1 pathway, which have strong potential on many inflammatory and metabolic disorders. Currently, the company is developing SUCZYME, a novel first-in-class oral enzyme therapy able to deplete succinate that has Crohn's Disease as a first indication. SUCCIPRO will lead the development until the end of Clinical Phase 2a, when the asset will be licensed to a bigger pharma company.Current proposal aims to conduct critical technical and business activities with the overall goal of raising a first seed investment round. From a technological perspective, during the project the team will advance in the development of the enzyme therapy by partnering with an innovative company expert in enzyme engineering able to improve our candidates in terms of specificity, activity and stability. Later, we will conduct in vitro and in vivo efficacy studies that will enable the designation of final lead candidate.  In parallel to the technical development, and in order to have more a more accurate vision about the European market, we aim to perform early price & reimbursement and market studies in Europe. We will also participate in the activities organised by InvestEU and the Enterprise Europe Network and we will introduce our company into the US start-up ecosystem to expand company's innovation network and look for investment in the US. Overall, the project will contribute to increase the TRL level of our asset, improve our competitiveness and visibility within the international biotech sector and support us in the raising of a seed investment round.


**Keywords:** succinate, enzyme therapy, me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustainable materials and process for green printed electronics (Sustain-a-Print) (SaP)' to be submitted under Horizon Europe.

assistant: **Abstract**

Prompted by the dire forecasts for increased resource extraction and waste generation, and their detrimental effects on climate and biodiversity, a Circular Economy Action Plan has been put forth where electronics and electronic equipment have been identified as a priority product group with circularity potential. With an annual growth in waste of 2%, this group is one of the fastest growing waste streams in the EU, while less than 40% of electronic waste is recycled within the EU. There is a need to explore new options for electronics that are designed for reuse, repair, and high-quality recycling. To address this challenge, several factors must be considered such as the Industrial End User’s (IEU) specifications, Life Cycle Analysis (LCA) and the products end-of-life (EoL). Printed electronics (PE) is an additive manfucaturing method that can address these challenges and is characterized by its versatility, scalability, and low material usage, thus making it an ideal candidate for a circular production of electronics in general. Flexible and even stretchable electronics can be obtained with this method by printing conductive and dielectric inks on flexible/stretchable substrates opening new applications in the market. However, similar to traditional electronic production methods, current life cycle for a PE product starts with materials (substrate, conductive and dielectric materials) obtained through mining of raw materials. These materials are put into production lines, consisting of large volume analogue printing, gluing on discrete components and lamination processes. The EoL are either landfills or incineration, which in both cases, destroys precious materials, thus forcing the use of mined raw materials. The main goal of Sustain-a-Print (SaP) is to open new life
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'MATERIAL DESIGN FOR ADDITIVE MANUFACTURING (MADAM)' (MADAM) under Horizon 2020.

assistant: **Objectives**

This projects aims to develop numerical algorithms for designing the new generation of advanced materials: Metamaterials.  Their impressive properties (one of the lightest, stiffest and strongest materials available today) arise from their non intuitive topologies.   Due to the additive manufacturing (AM) revolution or 3D-printing techniques, we are at the right moment where these complex topologies are now possible to be created.                                                                                                                  However, additive manufacturing has its own manufacturability constraints. Although several advances have been developed in the last years, most of these new advanced materials, specially mechanical metamaterials, have been designed with considering no manufacturability constraints, i.e., are just theoretically design. Even more worrying, when manufacturability is possible, they show severe symptoms of fragility or limited resistance. MADAM project seeks to solve these limitations incorporating manufacturability and resistance properties in the process of material design (MAD). The specific objectives are:1) Develop numerical algorithms to solve the MAD  problem when considering AM constraints.2) Develop numerical algorithms to solve the MAD problem when considering stress constraints.3) Develop second order optimization algorithms to efficiently solve the MAD problem.The project is throughly designed for maximizing training and transfer of knowledge to the host.  Risk and project management, IPR and Communication activities are also meticulously designed.Additionally, MADAM will be connected with the enormous multi-partner AM Sofia consortium (Michelin, EADS) by disseminating and attending (confirmed) to monthly industrial meetings
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multisite transition metal complexes - a new approach towards bistable molecular devices' in the context of a Fourth Framework call.

assistant: **Objectives**

The prospect of using molecules or small assemblies of molecules as elements in electronic devices establishes an exciting challenge for chemists. Bistable systems are the key building blocks of all digital electronic devices, such as imaging and information storage. In this proposal we present a novel approach to a bistable molecular system based on threaded multisite transition metal complexes. Our approach utilizes a rotaxane-type assembly, consisting of a molecular thread with two different coordination sites bidentate and tridentate , and a coordinating ring. The ring contains a bidentate coordination side, while its location on the thread can be electrochemically triggered through the oxidation state of the transition metal ion. Translation of the ring between the two coordination sites is controlled through a switchable gate, triggered by a second external signal. A system which contains the above described structural features can then be devised to undergo a cyclic series of transformations, establishing the requirements for a bistable molecular device. We anticipate that this new principle will open appealing perspectives for the design of molecular-based memories and devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'sRNA regulatory networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

MicroRNAs (miRNAs), a large class of ~22 nucleotide non-coding RNAs (sRNAs) found in many plants and animals act to post-transcriptionally regulate gene expression. Approximately 3% of all known human genes encode miRNAs. Important functions for miRNAs in development, physiology and disease are emerging.Here we propose to identify and characterize miRNA genetic networks by combining forward and reverse genetic approaches, experimental target identification, quantitative cell biology and computational analyses in C. elegans. We will focus our efforts on a set of 14 miRNAs that are conserved between C. elegans and mammals. Specifically, we will test genetic interactions between this panel of miRNA genes and all known genes in C. elegans using synthetic RNAi screens. Based on pilot studies we expect that these screens will identify direct targets of miRNAs as suppressors and genes acting redundantly with miRNA genes as enhancers. In parallel, we will use experimental approaches to identify the direct in vivo targets and upstream transcriptional regulators for these 14 miRNAs. Finally we will use a live assay for miRNA activity to measure the kinetics of the effects of miRNAs on the gene regulatory network.To our knowledge this is the first study to use synthetic genetic screens to uncover genome-wide miRNA regulatory networks. This project is taking advantage of a number of recent advances in C. elegans technology. We will deliver a unique dataset to further our understanding of the biology of individual miRNAs in C. elegans, the characteristics of miRNA regulatory networks in C. elegans and more generally miRNA-dependent control in animals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Virtual User Concept for Supporting Inclusive Design of Consumer Products and User Interfaces' to be submitted under Seventh Framework.

assistant: **Abstract**

The needs of people with sensory or dexterity impairments are generally not well considered when designing user interfaces (UIs) for mainstream consumer products.  The majority of existing interfaces and controls rarely fulfil the accessibility requirements of users suffering from visual, hearing, and dexterity impairments. It is also common for an individual to have multiple impairments than just one; this is particularly prevalent among older people. A combination of these impairments creates a far greater problem when interacting with a product than just one.<br/>The audience for VICON will be older people who have age-related (mild to moderate) impairments (age-related hearing loss, macular degeneration, etc) rather than those with profound impairments. This group of people do not want (or require) 'specialist' assistive devices but mainstream consumer products. However they fully benefit from consumer products, when their UIs incorporate accessible multimodal interaction capabilities providing good usability.<br/>It is unrealistic for a mainstream manufacturer to have a detailed understanding of these issues and design appropriately, due to the complexities of singular and multiple age-related impairments. Therefore their inclusivity knowledge has to be supported from a third party solution.<br/>VICON will conduct extensive user research to build an advanced Virtual User Model that will reflect the requirements of this group, when designing a product or UI. The Virtual User model will accompany the entire design process and support the client throughout, so that the needs of this audience are address at every stage; conceptualisation, product and UI specification, virtual testing and prototype evaluation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Recycling of wastes from ornamental calcareous stone industry on agriculture and other industrial sectors'.

assistant: **Innovation**

Extraction and conventional processes for cutting and machining natural calcareous stones generate by-products, which are, usually, rejected, and non-recycled. Therefore, the consequences are both the environmental problem caused by the accumulation of this waste and the fact that no use is made of a by-product that might have a wide range of applications mainly in agriculture usage (soil rehabilitation, fertilisers,) and in other industrial sectors. The proposer SMEs are very interested in this project whose main objectives are i) to evaluate the environmental impact of by-products generated in the cutting/machining processes and to reduce the amount of waste generated by optimising the process itself and, ii) to recycle these by-products reusing it as a raw material (unmodified or treated) for agriculture usage, and for other industries. Currently, there are not viable solutions to the problem and a systematic research has not been done in this matter. This problem has a clear European dimension because it involves to different countries and the total volume of