RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Efficient public policies for the take-off of agricultural biomass-to-energy projects in greece in the context of the european union c.a.p.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The objective of this study is to evaluate the possibilities of viable bio-energy projects in pilot or larger scale in Greek arable farming systems and to explore efficient public policies to support this activity based on multiple criteria analysis, using models elaborated in INRA, France.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Ocean DYNAmics reconstruction using remotely sensed variables in two CLIMate hotspots' (DYNACLIM) under Horizon 2020.

assistant: **Objectives**

By transporting heat and energy, ocean currents play a major role in shaping the climate of Earth’s many regions. However, characterization of ocean dynamics remains one of the key problems in oceanography. This project addresses the reconstruction of ocean currents from satellite observations. Using two semi-analytical quasi-geostrophic models and proposing a new numerical approach, this proposal aims to exploit the available spatiotemporal sampling capacity of remotely sensed salinity synergistically with sea surface temperature and sea surface high to reconstruct the ocean three-dimensional dynamics. This approach will be applied to the Arctic Ocean and the Mediterranean Sea; two regions of relevant importance in order to better understand the consequences of climate change and where enhanced satellite salinity products are recently being produced. Reinforcing knowledge both on the Mediterranean and Arctic dynamics represent a community priority as they represent key navigation areas, the Mediterranean Sea for its actual navigation transit and the Arctic Ocean if the near future makes ice melting worst predictions a reality and the possibility to navigate through the Northern Pole opens. Moreover, improving the circulation understanding in these areas would also contribute to European politics to reduce the climatic impact of maritime transport contamination.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Serotoninergic Regulation of Body Axis Morphology' (SeRBoMo).

assistant: **Concept**

Idiopatic scoliosis (IS) is a human pathology that affects 1-4% of adolescents worldwide, who suffer from spine deformities for which an effective treatment is not currently available. At present, evidence for genetic causes of IS exist, but the aetiology of this pathology is still not understood. The zebrafish is a powerful organism to model human pathologies that entail body axis misalignment as, by swimming in a viscous liquid, its spine is subject to forces similar to the ones acting on the spine in bipedal position. One essential player in the establishment of embryonic zebrafish longitudinal axis is the Reissner Fibre (RF). The RF consists of SCO-spondin protein, which, during post embryonic life, is secreted by a paraventricular organ, the SCO. Zebrafish scospondin mutants lack the RF and exhibit severe scoliotic phenotype. Remarkably, a similar scoliotic phenotype is observed in the tph2-/- zebrafish, genetically depleted of serotonin. Preliminary observations have shown that serotoninergic projections reach the SCO, in mammals and in the zebrafish. My research objective is to unravel how the neuronal activity of serotoninergic neurons can control the maintenance of a straight longitudinal body axis during the zebrafish post embryonic life. Firstly, a detailed characterisation of spine alignment in correlation to RF assembly will be carried out in the tph2-/- zebrafish. Secondly, the serotoninergic neurons projecting to the SCO will be anatomically located and mapped. Thirdly, the neuronal mechanism by which serotoninergic neurons regulate RF maintenance will be functionally investigated. The long-term goal of this research project is to gain insights in the progression of IS, and to inform preclinical research on the development of diagnostic tools, which are c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced Energy STorage and Regeneration System for Enhanced Energy Management' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

ESTEEM Consortium will bring together their world-leading expertise in aircraft Electrical Power Systems (EPS), Power Electronics (PE), advanced control systems, modelling and simulation for aerospace applications, Energy Storage System (ESS) and smart and Enhanced Electrical Energy Management (E2-EM) strategies to design, develop and manufacture an innovative Energy Storage and Regenerative System ESRS with embedded supercapacitors Energy Storage Device (ESD) for smart energy management of a regenerative Electro-Mechanical Actuator (EMA) emulator. The developed system components; ESD and EMA emulator will be connected together by a Secondary Electrical Distribution Centre (SEPDC) to constitute the ESRS. Then, the ESRS will be interfaced with the “Iron Bird” to demonstrate the concept of advanced Electrical Power Distribution System (EPDS) with E2-EM functionalities. The aim is to demonstrate the E2-EM functionalities for future aircraft EPDS and contributing towards the achievement of more efficient, greener aviation. The developed demonstrator will be efficient, reliable, compact and lighter and smarter.The key system component will be a newly designed DC/DC converter for interfacing the supercapacitors ESD with the SEPDC, which will be under control of supervisor to implement E2-EM functionalities and energy-management algorithm. Intelligent and adaptive converter control algorithm will be developed to provide high dynamic performance essential for fast control of peak power under situations of gird parameters variation. The converter control will consider the implementation of state of health and monitoring algorithms for the supercapacitors ESD.The ESTEEM innovations will reach the market through integration within the Regional IADP in Clean Sky 2. The project part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A Multi-agent Approach to Digital Business Ecosystems' (ECOBUSINESS), addressing dissemination and exploitation.

assistant: **Impact**

The purpose of EcoBusiness is, on one hand, to increase the productivity and the position in the market of MicroArt (and other similar SMEs) by applying cutting edge techniques and methodologies coming from academia, either from the field of management and economics, through the MSE-UEDIN, as well as from the field of artificial intelligence and information systems, through the collaboration with CISA-UEDIN, while giving the opportunity to the university (UEDIN) to test the products of its research in a real scenario while acquiring all the expertise from a real SMEs market network. On the other hand, this programme pretends to facilitate the acquisition of knowledge by the experts at MicroArt on recent research fields such as interaction-centered knowledge sharing, information ecosystems, and digital business ecosystems, while offering the researchers at UEDIN the  necessary knowledge to know how to test and evaluate their research findings and results in real-like scenarios.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Protein engineering for the study of detoxification enzymes and hub proteins' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Proteins that exhibit broad specificity play important roles in different biological processes. These proteins include enzymes that catalyse the chemical transformation of many different substrates and proteins that bind to multiple protein partners. We propose to develop and apply novel directed evolution and chemical genetic methodologies for the study of proteins that exhibit broad specificity, with focus on cytosolic sulfotransferases (SULTs), which detoxify a broad range of xeno- and endobiotics, and proliferating cellular nuclear antigen (PCNA), which binds to multiple protein partners to play a central role in DNA replication and repair. SULTs belong to a large family of detoxification enzymes that exhibit broad specificity and relatively poor catalytic efficiency. It is not clear how SULTs can detoxify a variety of different compounds and what constitutes the molecular basis for their broad specificity. Application of directed evolution methodologies will allow us to identify and isolate SULT mutants with improved catalytic efficiency and novel specificity. These mutants will be thoroughly characterised by applying a variety of biochemical and structural methodologies to provide new insights into the broad specificity, catalytic activity and biological functions of SULTs. In parallel, we propose to develop and apply directed evolution methodologies for the study of PCNA. PCNA is a homotrimeric hub protein that forms a DNA sliding clamp to mediate DNA replication and repair by recruitment of a variety of essential proteins to the DNA template. Very little is known about how these multiple binding choices are regulated or about the importance of the different PCNA-protein interactions at different stages of replication. We propose to generate PCNA mutants with new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Interferometric sar data processing'.

assistant: **Innovation**

Interferometric Synthetic Aperture Radar (IFSAR) is a technique for ra and accurate topographic mapping.  The Digital Elevation Model (DEM) of the scene under investigation is built up by using the phase difference of the signals received by two spatially separated antennas. However, the measured phase difference is restricted to the range [-Pi, Pi], whereas the useful one covers a larger range.  The DEM generation is, therefore, carried out by: conventional SAR dat processing of the two received signals, accurate registration of the two complex images, and phase unwrapping of the measured phase difference.  Concerning the phase unwrapping techniques, the difficulties involved this particular application are given by the typical SAR system geometry. As matter of facts, when the terrain slope grows the measured phase difference may result undersampled (layover regions). Furthermore, due to either decorrelation or shadow effects, the measured signals may have low Signal-to-Noise ratios.  The above mentioned aberrations render the inversion from measured pha to DEM profile very difficult, and the uses of local inversion techniques generate global errors.  The objective of this project is to examine the possibility to use SAR focusing algorithms that directly generate registered images and the use of global phase unwrapping techniques that confine the DEM errors around the aberration sources.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Roles of Pitx, Dach and Meox genes in adult skeletal muscle stem cells' in the context of a Seventh Framework call.

assistant: **Objectives**

Stem cells are present in many adult tissues in a quiescent state. Their contribution to tissue repair depends on their activation, leading to proliferation and subsequent differentiation or return to quiescence. Skeletal muscle provides a model in which to study adult stem cell behavior. This tissue regenerates after injury and the muscle satellite cell is key to this process. These quiescent cells, located under the basal lamina of muscle fibres become activated upon injury, proliferate and differentiate into new muscle fibres or revert to quiescence. Examining the different states that a satellite cell can adopt under physiological conditions should lead to the identification of new regulators of myogenesis, and contribute to a better understanding of the mechanisms controlling quiescence and activation. Transcriptome analysis were performed on purified satellite cells isolated from adult muscles where these cells are quiescent and from growing or regenerating muscles, where they are activated. This analysis provided new insights into the genes differentially expressed in both states. My project will be to follow up on this work by focusing on three genes, Dach1, Meox2 and Pitx2/3. Those genes encode transcription factors whose profiles suggest they are involved in the function of muscle adult stem cells. Proliferation and differentiation of satellite cells will be studied in vivo in regenerating muscles of Pitx2/3 conditional mutant mice, or after inhibition of Dach1 and Meox2 expression by RNAi viral infection of injured muscle. Similarly, ex vivo proliferation and differentiation of satellite cells in single fibers and primary cultures will be analyzed after Dach1 or Meox2 knock-down by RNAi. Conversely, the consequences of the over-expression of these genes will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Enhanced preventive antiparasitic treatment for better health of African pregnants and their babies' (TreatPreg) under Horizon Europe.

assistant: **Objectives**

Pregnant women in Africa are exposed to considerable health risks, with parasitic infections being a major threat. Schistosomes, soil-transmitted helminths, and malaria parasites are highly prevalent and polyparasite infections are common. In pregnancy, besides iron deficiency parasites are a key factor causing anaemia associated with an increased risk of maternal and infant morbidity and mortality. More than 50% of the pregnant women are affected by anaemia and an estimated 0.8 million pregnant women globally have severe anaemia. Antenatal care is a health program to regularly deliver health services including preventive measures with the aim of improving maternal and newborn health. In terms of fighting parasitic diseases, WHO recommends to preventively treat soil-transmitted helminths, schistosomes and malaria parasites. In many endemic sub-Saharan African countries, however, these recommendations are often only partially implemented and not consistently applied in daily antenatal care. Reasons are multifactorial but hesitation in administering multiple drugs this vulnerable population and the complexity of integrating the use of multiple drugs into the antenatal care schedule. On the other hand, data is accumulating that outweighs the potential risk of antiparasitic drug intake versus health benefits.The project aims to increase the uptake and integration of presumptive antiparasitic treatment during pregnancy to combat anaemia and improve health outcomes for pregnant women and their babies in sub-Saharan Africa. To this end, a multi-country trial will assess the safety, tolerability and efficacy of co-administered antiparasitic drugs. Pharmacokinetic data, cost-effectiveness analysis and public health stakeholder’s involvement will further strengthen the case for f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Engine Integration on Future Transport Aircraft' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

BE95-1049 Engine Integration on Future Transport Aircraft - ENIFAIR For the development and successful marketing of new or modified transport aircraft the use of the new, high efficient engines with ultra-high bypass ratios will be of major importance, since they offer drastic reductions in fuel consumption, noise and emissions. The large diameter of these engines in context with requirements concerning ground distance, weight etc. leads to the necessity of a very close coupling with the wing. This however covers the danger of negative aerodynamic installation effects, which could compensate the possible gains and hence lead to large financial losses. Since today in Europe the knowledge about the underlying flow phenomena is very limited, it is an urgent need of highest importance and consequently main objective of the proposed programme ENIFAIR, to provide the partners from airframe- and engine industry involved with a corresponding common high-quality data base and to develop the tools, necessary for later product developments.The experimental part of the programme makes partial use of hardware from the earlier EC-programme DUPRIN and covers:- manufacturing of VHBR-engine simulators;- high-speed investigations on a model with turbofan/VHBR/UHBR engines in the ONERA S1 wind tunnel;- low-speed tests in DNW on a model with VHBR engines including detailed flow field measurements by using the Particle Image Velocimetry technique;- development of a thrust reverser for VHBR-engines and tests on DNW-model. The numerical part is concentrating on adaptation and application of codes for - investigation of effects due to varying engine positions - calculation of jet behaviour for isolated engines - calculations of viscous flow fields around cruise- and high-lift configurations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial for improved electromechanical coupling, cardiac cell retention and delivery of paracrine factors' (HepEDOT) targeting Horizon 2020.

assistant: **Abstract**

Cell therapy has emerged as a promising therapeutic strategy for cardiac repair, showing modest cardiomyocyte protection and infarct size reduction. It is under debate whether these outcomes are due to the implanted cells or their paracrine factors, as cells are scarce within a few weeks post-implantation. Regardless, this is still not sufficient to promote cardiac remuscularization and reverse medium to severe myocardium injury and fibrosis. Improved cell retention has been achieved with a substantial bulk of implanted cells, but highly associated to graft-induced arrhythmia, representing a significant challenge for clinical translation. The present study seeks to promote cardiac remuscularization after infarct, by improving the retention of cardiac cells and their paracrine factors without causing graft-induced arrhythmia. To do so, a conductive, self-doping and biodegradable oligoEDOT-heparin biomaterial will be synthesized and studied on in vitro and in vivo cardiac infarct models. The conductive EDOT oligomer moiety is envisaged to act as an electrical sink to shield the cardiac tissue from mismatched electromechanical impulses, while heparin will facilitate cardiac cell support and loading of regenerative factors, besides its recently documented doping capacity. The results of this fellowship are expected to overcome low cell retention and graft-induced arrhythmia, two of the biggest obstacles for translation in cardiac cell therapy, but also contribute with new insights regarding conductivity in materials and biological systems, to multiple fields of materials chemistry, medicine and bioelectronics. The world-class academic environment, collaborations and combined interdisciplinary expertise in biomaterials and cardiovascular sciences make the proposed fellowship