RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Long-term coastal adaptation, food security and poverty alleviation in Latin America' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

TRADITION aims to understand the long-term trajectory of human interaction with coastal resources and its legacy to present day small-scale fisheries in Latin America. Founded on traditional knowledge rooted in the past, small-scale fisheries are a crucial source of food and livelihood for millions of people worldwide, and play a pivotal role in poverty eradication in developing countries. A thorough recognition of the cultural and socio-economic significance of Latin American fisheries requires a temporal component that only archaeology and history can provide. TRADITION will investigate a 4000-year record of coastal exploitation in one of the world's most threatened tropical environments: the Atlantic forest of Brazil. We will draw together archaeological, palaeoecological, historical and ethnographic records to address fundamental questions that impinge upon our current understanding of the development of small-scale fisheries in this region. How did coastal economies adapt to the spread of agriculture? What was the impact of past climate and environmental changes on coastal populations? What was the impact of European colonisation of the Americas on the development of small-scale fisheries? What was the role of historical institutions and regulations in the negotiation between traditional and modern practices in small-scale fisheries? How have the historical practices and events shaped current small-scale coastal communities, and can this knowledge benefit current management strategies. The answers will help us understand how coastal economies responded to unprecedented societal and environmental changes by adapting their subsistence practices, technology and culture, while contributing to the foundation of coastal societies in Latin America.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of microsensors for use in the marine environment' (MICROMARE) under Fourth Framework.

assistant: **Objectives**

The overall objective of the project is to develop, improve, and test microsensors and signal processing systems for in situ use in shallow water and deep sea environments. The proposed achievements will make it possible to perform in situ determinations of 1) concentrations of dissolved constituents  in sea water, 2) fluxes over the sediment-water interface, 3) fine scale depth profiles of concentrations and biogeochemical processes in the sediments, and 4) physical sea floor characteristics. Microsensors are defined by their minute(0.005-0.050 mm) total tip diameter. The small size of microsensors makes it possible to perform determinations with a minimal disturbance of the environment. The small size also makes it possible to develop novel sensors, where the efficient diffusional transport over short distances is used to supply reactants to the signal-producing zone within the sensor. Other advantages of micro-scale sensors include rapid response, low detection limits, long-lasting internal reservoirs of reactants and low power consumption. The sensors to be developed or adapted can be classified in three major categories: -biosensors: for the measurement of methane, nitrate, sulphate, and sulphide -electrochemical sensors: for the measurement of flow and sediment diffusivity -optical sensors (optodes): for the measurement of oxygen, pH, carbon dioxide, and the position of the sediment surface. Measuring systems including optics and electronics will be developed to enable use of the sensors in shallow waters and in the deep sea. The measuring systems will be designed for low power consumption and minimal space requirement. In situ tests will be performed on a deep sea lander profiling the sediment at 0.025 mm resolution and on unmanned platforms for monitoring of sea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Overcoming resistance to immunotherapy: Immunostimulatory tumor-derived extracellular vesicles as multifunctional anticancer agents' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Tumor immunotherapy with immune checkpoint inhibitors (ICI) has unprecedented therapeutic potential, but its success is limited to a minority of patients with preexisting antitumor T-cell immunity. For patients with poorly-immunogenic tumors, combinatorial immunotherapies are urgently needed. With a vast and bioactive cargo (proteins, lipids, nucleic acids), extracellular vesicles (EVs) have intrinsic property to regulate complex pathways in distant target cells. Even though they can transfer tumor antigens which potentially activate T cells, tumor-derived EVs (TEX) have mainly been associated with immunosuppressive function. I have recently identified innate immune pathways within tumor cells that regulate TEX biogenesis and immunogenicity. This allows for the first time to force tumor cells to release a defined immunostimulatory (is)TEX product. The unconventional objective of IMMUNO-TEX is to generate a platform for the pioneering therapeutic use of tumor-derived isTEX as multifunctional cell-free anticancer agents. isTEX combine a cargo of a plethora of patient-specific tumor (neo-) antigens and immunostimulatory constituents within a single, non-toxic delivery vehicle, that allows for efficient priming of tumor antigen-specific T cells. The ability to harness the vast potential of isTEX is directly interwoven with a more detailed mechanistic understanding how tumor-specific cargo packaging in EVs occurs and how they alter immune cell function. Therefore, IMMUNO-TEX will identify and exploit the intracellular machinery in tumor cells for optimal isTEX generation, investigate how isTEX enable an immune-supportive tumor microenvironment, and validate isTEX to overcome ICI resistance in relevant murine and human model systems. Hereby, IMMUNO-TEX will eliminate current
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Robotic Synthesis Farm' under Horizon 2020.

assistant: **Concept**

Scientists in academia and industry who perform R&D in nature and life sciences are facing problems related with commercially availability of synthetic novel compounds. UAB SynHet novel RoboSynFarm approach addresses the disruptive and innovative solution for broader sustainable synthetic compounds accessibility targeted customer demand with significant impact not only on the final, more affordable synthetic product price but also on lower energy consumption and greener environmental impact.


**Keywords:** Organic chemistry, Organic synthesis, Farm, AI, Machine learning, Neural network
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Targeting novel lipid pathways for treatment of cardiovascular disease'.

assistant: **Objectives**

Lipid lowering has significantly reduced cardiovascular disease (CVD) mortality in EU. However, the aim to abolish CVD in EU is far from achieved and attempts to improve on the benefits of statins with new agents have not yet delivered new therapeutics.  The Consortium Athero-Flux builds on FP7-generated large-scale lipidomics data showing that specific sphingolipids and in particular distinct ceramides with specific acyl chain lengths are better predictors of CV outcome than traditional risk factors such as low-density lipoprotein-cholesterol. Sphingolipids are implicated in significant biological activities including cell survival, inflammation, and metabolic diseases. Moreover, their levels in metabolic diseases are modulated by previously unrecognized factors such as the gut microflora. Thus, we hypothesize that by controlling sphingolipid metabolism a better primary and secondary prevention of CVD events than with statins alone can be achieved.  Athero-Flux builds on cutting-edge SME-led biotechnological tools including: a) high-throughput lipidomic platforms that allow the study of kinetics of lipid metabolism at the molecular lipid level including the new stable isotope labelling technique (Flux); b) whole genome RNA interference screening tools that will allow to identify the regulators of the production of ceramides and the mediators of their biological effect; c) unique locked nucleotide antagonist platforms that have been successfully used clinically in more that 300 patients worldwide. Moreover, it involves Academic partners with top expertise in atherosclerosis, sphingolipid metabolism, and gut microflora to validate targets in the ceramide metabolism. The identification and the validation of the best targets to abate ceramide metabolism though a combinatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'How do infants mentalize? Bringing a neuroimaging approach to the puzzle of early mindreading.' (DEVOMIND).

assistant: **Concept**

Human social interaction and learning depends on making the right inferences about other people’s thoughts, a process commonly called mentalizing, or Theory of Mind, a cognitive achievement which several decades of research concluded was reached at around age 4. The last 10 years has radically changed this view, and innovative new paradigms suggest that even preverbal infants can think about others’ minds. This new developmental data has created arguably one of the biggest puzzles in the history of developmental science: How can infants be mentalizing when years of research have shown that a) pre-schoolers fail at mentalizing tasks and b) mentalizing depends on the development of cognitive control, language, and brain maturation? The key issue is whether behaviour that looks like infant mentalizing really is mentalizing, or might infants’ success belie alternative processes? The most powerful strategy for resolving this puzzle is to look to brain activity. By applying the same methods and paradigms across infancy and early childhood, DEVOMIND will investigate whether infants’ success on mentalizing tasks recruits the same network of brain regions, and neural processes, that we know are involved in success in older children and adults. In the second half of the project, we will use our neural indicators of mentalizing to test a completely novel hypothesis in which infants’ success is possible because they have a limited ability to distinguish self from other. Although novel, this hypothesis deserves to be tested because it has the potential to explain both infants’ success and preschoolers’ failures under a single, unified theory. By bringing a neuroimaging approach to the puzzle of early mentalizing, DEVOMIND will allow us to move beyond the current impasse, and to gene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synthetic metabolic pathways for carbon fixation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Carbon fixation is the main pathway for storing energy and accumulating biomass in the living world. It is also the principal reason for humanity s utilization of land and water. Under human cultivation, carbon fixation significantly limits growth. Hence increasing carbon fixation rate is of major importance towards agricultural and energetic sustainability.Are there limits on the rate of such central metabolic pathways? Attempts to improve the rate of Rubisco, the key enzyme in the Calvin-Benson cycle, have achieved very limited success. In this proposal we try to overcome this bottleneck by systematically exploring the space of carbon fixation pathways that can be assembled from all ~4000 metabolic enzymes known in nature. We computationally compare all possible pathways based on kinetics, energetics and topology. Our initial analysis suggests a new family of synthetic carbon fixation pathways utilizing the most effective carboxylating enzyme, PEPC. We propose to experimentally test these cycles in the most genetically tractable context by constructing an E. coli strain that will depend on carbon fixation as its sole carbon input. Energy will be supplied by compounds that cannot be used as carbon source. Initially, we will devise an autotrophic E. coli strain to use the Calvin-Benson Cycle; in the next stage, we will implement the most promising synthetic cycles. Systematic in vivo comparison will guide the future implementation in natural photosynthetic organisms.At the basic science level, this proposal revisits and challenges our understanding of central carbon metabolism and growth. Concomitantly, it is an evolutionary experiment on integration of a biological novelty. It will serve as a model for significantly adapting a central metabolic pathway.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Recycling technologies for ELV components to create a sustainable source of market grade materials for EU applications'.

assistant: **Concept**

CRUSADE upscales novel technologies to TRL7 integrated in a universal hydrometallurgical method to recycle up to 500 tn/year of spent automotive components (autocatalysts, fuel cells, batteries and printed circuit boards) from end-of-life vehicles and recover ca 40 tn/year of critical raw materials (Cu, C, Co, Mn, Ni, Pt, Pd, Rh, Li, Ru) at commercial specifications. The project leverages predeveloped technologies to establish a market ready pilot unit utilising novel concepts for material tracing using blockchain (AKO, SAISLAB, ENTE) and pan European collection network establishment from the pioneers of the automotive components manufacturers (SUN, ADV, CRF, MONO, ACU) which guarantee the long term sustainable operation of the unit. The material processing covers the whole chain from pre-treatment using validated technologies from the experts on the CRMs recovery (MONO, TUBAF, KUL) and upstream processing using a microwave assisted leaching methodology enabling a 15-80% lower CO2 emission process (depending on the feed), compared to commercial processing. High specification market ready materials are prepared as outputs of the project undergoing a downstream purification and recovery process using solvent extraction and electrowinning, guided by industrial standards for end-use applications, while validated and benchmarked during the course of the project in new automotive products. The processing is automated aiming to a 15% time reduction compared to current processes with the use of an industrial robot and artificial technology guiding the sorting and the hydrometallurgical treatment (Industry 4.0 concept). The materials are commercialised at 15% lower price compared to market standards due to the automated innovative cost efficient processing, CAPEX/OPEX reaching m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Towards effective and efficient pest management in agriculture'.

assistant: **Concept**

Résumé: The reduction of environmental and health risks from pesticide use is a major challenge for agriculture and on top of the agricultural policy agenda. Despite substantial efforts, current pesticide policies have not reached their reduction targets. Recent research shows that targeting farmers’ application behavior could be key for advancing pesticide policies. However, our theoretical understanding of the farmers’ decision-making process is limited and empirical studies on the main drivers of inefficient decisions are missing. The interdisciplinary PESTEFFECT project will i) advance our understanding of farmers’ pesticide use decisions, ii) quantify impacts of the main drivers of inefficient decisions, and iii) identify risk reduction potentials on a regional level. In the project, we will i) develop a conceptual and empirical model of farmers’ pesticide use decisions that integrates concepts from agricultural economics, agronomy, and ecology, ii) provide the first empirical analysis of economic and environmental effects of inefficient pest management decisions using an econometric model and iii) provide temporally- and spatially explicit assessments of risk reduction potentials on a regional level using multi-layered maps. For our analysis, we will use a unique, long-term dataset on farmers’ management decisions, environmental conditions, and biodiversity (losses) from Western France. Results will support the development of pesticide policies targeting inefficient pest management decisions and the creation of guidelines for farmers and farm advisors. The project will thus contribute to a more sustainable agriculture in Europe.


**Keywords:** Agricultural Economics,  Pesticides,  Environment and Health Risks,  Farmers' Behaviour,  Risk Reduction,  Pesticide Poli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Towards prevention, early diagnosis, and noninvasive treatment of uterine leiomyomas through molecular classification' in the context of a Horizon 2020 call.

assistant: **Objectives**

Every fourth woman suffers from uterine leiomyomas (ULs) – benign tumors of the uterine smooth muscle wall - at some point in premenopausal life. ULs, also called myomas or fibroids, cause a substantial health burden through symptoms such as excessive uterine bleeding, abdominal pain and infertility. These tumors are the most common cause of hysterectomy. Considering the impact that ULs have to women’s health, they are severely understudied. Our breakthrough work has shed important new light on the biology and genesis of ULs. In this ERC proposal we hypothesize that ULs can emerge through several distinct mechanisms and anticipate that each mechanism contributes to somewhat different tumor biology, clinicopathological features, and response to treatment. Also, we hypothesize that predisposing genetic variants may confer susceptibility to a particular UL subclass. To test these hypotheses, we shall create multiple layers of high-throughput data on clinicopathologically characterized ULs, including copy number variation, whole genome sequence, gene expression, and methylome profiles. Integration of these data should establish the existence and key characteristics of the different UL subclasses. Finally, we shall examine the effect of currently used drugs as well as new lead compounds in response to treatment, stratified per UL subclass. These efforts will 1) provide biological insight into molecular mechanisms driving the UL genesis and lay the scientific basis of their molecular classification, 2) describe the key characteristics of each class, 3) provide key biomarkers and molecular tools for routine diagnosis of UL subclasses, as well as clues to their targeted treatment, and 4) produce tools for detection of hereditary predisposition to ULs. This ERC project will be a