RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Toolset for development of high performance and energy-efficient software, realising the potential of ubiquitous computing and the Internet of Things'.

assistant: **Innovation**

The huge, emerging market that is referred to by terms such as ‘ubiquitous computing’ and the ‘Internet of Things’involves not mere hundreds of millions, but tens to hundreds of billions of processors.When planning to manufacture ten to the tenth or eleventh power of items, cost rules;when planning to deploy them, energy efficiency and maintenance cost rule.Conventional processors, running legacy software, were never designed to address these three crucial considerations.We believe that the wisest way to ameliorate this problem is to abandon legacy software that has been driving conventional computer architectures and address these demanding problems in a fresh, simple way.The GreenSoft project targets development of a novel, highly productive and energy-efficient programming framework and software toolset to synergetically support use of state of the art low-energy processors. Our approach addresses the critically important need for the combination of high performance and energy-efficiency, which is the key to fully realise the potential of ubiquitous computing and the Internet of Things.The GreenArrays GA144 is a recent example of a low-power spatial processor, composed of many small, simple, identical cores.The novel architecture is optimised for performance, i.e., speed combined with low power consumption.However, traditional compilers and other existing software tools do not support such emerging multi-core processors.GreenSoft represents a new paradigm for efficient product development, taking full advantage of inherent benefits made available by the technology.By generating compact and highly efficient programmes which fully exploit inherent low-power capabilities of processor architecture, compounded with the benefits of processor hardware that consumes only 1%
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Handheld Molecular Contaminant Screener'.

assistant: **Innovation**

There is an ever-increasing need for real time detection for risk related substances (e.g. pesticides, bacteria and antibiotics) in agro and food products. Food quality, food frauds and food scandals are becoming a major issue these days. Prime examples of recent food disasters are the Fipronil Dutch egg scandal and Salmonella French baby milk scandal. These scandals have not only resulted in health effects but also resulted in massive economic losses (> € 600m), losses in jobs and damage of the reputation of the European agro and food industry which takes pride in being the best in the world. Current high-end screening methods are laboratory based which are time consuming (5-12 days) and expensive (€200 per hour of testing cost at central labs). By the time results are out, food is already in the processing stage or in the supermarkets. We propose real-time detection of risk related substance using handheld molecular contaminant screener (HMCS) based on a novel portable mass spectrometry technology. With HMCS rather than bringing the sample to the lab you bring the lab to the sample. HMCS enables food companies to test food or food products for contaminants before collecting food from the farms and at various stages of the food value chain. We have validated by speaking with customers such as Freisland Campina (the world’s largest dairy co-operative) and Vion food group to name a few who indicated to pilot HMCS based on the success of feasibility study. The feasibility study in phase 1 will technically validate the value of HMCS validate in terms of sensitivity (parts-per-billion), portability (< 9kg) and speed of detection (< 30 seconds). The economic feasibility study should provide lacking information about the decision making unit (farmer-food companies relationshi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Bulgarian awareness for participation in transnational research and innovation schemes in Europe' (BAOPITR), addressing dissemination and exploitation.

assistant: **Impact**

Bulgaria is for the first time fully associated to the European RTD Framework Programme. Bulgarian SMEs and RTOs lack information and support regarding their possibility to participate, and even lack technological tools (i.e. Internet, e-mail, etc.). There is an urgent need to be informed, trained and supported in FP5 project preparation and participation. The objectives of the project are to raise awareness among them regarding the opportunities of the FP5, and to develop transnational cooperation between Bulgarian and European SMEs and RTOs.The objectives will be achieved through the organisation of 7 awareness and training workshops on FP5, covering the whole Bulgarian territory, address all issues related to the participation process, clarifying procedures, and answering questions on problems faced. The expected results are the enhanced participation of Bulgarian entities in FP5.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tumor targeting through a TME-specific regulatory code and programmable CAR T cells' (TRAP-CART).

assistant: **Concept**

Two major issues hamper successful treatment of solid cancers with CAR T cells. First, immunosuppression imposed by the tumor microenvironment (TME) can compromise CAR T cell function. Second, CAR T cells require specific antigens for precise tumor recognition to limit/avoid toxicities associated with on-target/off-tumor activity. Initial attempts to overcome these challenges included immune checkpoint blockade and tunable CAR T cells. Here, we propose to develop a conceptually new framework for solid tumor therapy that introduces genetically modified, blood-derived TME cells as Trojan horses to deliver inflammation and broadcast “intratumor” signals that activate programmable CAR T cells. Overall, we will design a hematopoietic stem cell (HSC)-directed strategy for Tumor microenvironment-Regulated Activation of Programmable CAR T (TRAP-CART). This project builds on the host lab’s expertise in high-throughput genomics, bioinformatics, and CAR T cells, and on my own background in HSC engineering.Through epigenome/transcriptome profiling, we will systematically identify gene-regulatory elements that are specific to blood-derived cells in the TME. We will use such regulatory sequences for HSC-directed gene therapy, such that their progeny will express a programmed transgene only in the immediate vicinity of tumor cells. This TME-regulated transgene will induce inflammation (to help overcome the hostile immune environment of many solid tumors) and/or release localized activatory signals for CAR T-cells (making it possible to use weakly specific CARs while avoiding on-target/off-tumor activity elsewhere in the body). We will focus on melanoma as our “model cancer”, which has a high mutational burden, good mouse models and is widely used for testing cutting-edge immunotherapi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative, cost-effective, ultra-compact MRI-guided therapy system for diagnosis and immediate treatment of Parkinson's Disease' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Currently, there are 1.2M people afflicted by Parkinson’s disease (PD) only in EU and the incidence is forecast to double by 2050 primarily as a result of the ageing population. They require high invasive treatments when drug therapy and early medication are not effective anymore. Then, Deep Brain Stimulation (DBS) is the most commonly performed surgical treatment for Parkinson's patients, consisting in electrical stimulation of the deep regions of the brain responsible for movement disorders such tremors, stiffness and trouble walking. However, this treatment is highly-invasive and may lead to serious complications like hemorrhages and infections. Neuroparticle developed the Magnetic Particle Therapy (MPT), an ultra-compact, low-cost and non-invasive system for DBS in PD treatment. This stimulation is performed by image-guided placement of magnetic nanoparticles into the brain. The Neuroparticle’s system has been tested in various pre-clinical trials with excellent results published on peer- reviewed medical journals and presented at scientific conferences. This technological breakthroughs also enables meaningful reduction in size as it weighs only 90 kg and is perfectly head-sized (no shielding needed), saving hospitals valuable space and requiring less initial investment on setup labor. Finally, preliminary cost estimates show that the Neuroparticle’s system will allow hospitals to save up to 2/3 on cost of purchase and installation relative to competitors. During the Phase 1 feasibility assessment, in conjunction with partners, Neuroparticle will identify specific private hospitals to sell to. Target markets of Germany, Italy and Spain will be sized and contacts established. A supply chain procedure will be established in order to insure fast delivery for machine se
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A disruptive hypoxia activated prodrug for the treatment of resistant cancers: an AI-driven approach' under Horizon Europe.

assistant: **Concept**

TUMAGOSTIC will advance the development of CP-506, a next-generation Hypoxia Activated Prodrug (HAP) for the treatment of hypoxic tumours, representing over 50% of all solid tumours. CP-506 overcomes the limitations of previous HAP development attempts and can provide more targeted treatment compared with alternatives such as chemo-immunotherapy combination and PARPi. Our approach, combining CP-506 with improved patient targeting based on two AI-driven biomarkers (tumour hypoxia and Homologous Recombination Defect), has high potential to increase the effectiveness of standard of care therapies such as immunotherapy (IO) in combination therapy (prodrug-IO) and improve patients progression free survival and quality of life in several cancer types. We aim to advance CP-506 towards commercialization by carrying out a phase I-IIa clinical trial and corresponding business development activities, paving the way for a licensing agreement with the potential to exceed 450M.


**Keywords:** Hypoxia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'All-in-One Cell Screening Chip: Device for Affordable High-Throughput Cell Screenings' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Experiments with live cells are fundamentally important in biology, pharmaceutical industry, biotechnology or in medicine and diagnostics. One important example of cell experiments is the prescreening of cells from cancer biopsies with anticancer drugs in order to identify the most effective and least toxic combination of drugs for a particular patient also known as personalized medicine.The goal of this ERC Proof-of-Concept project is to develop, fabricate and optimize a device (CellScreenChip) for performing miniaturized, parallel and, therefore, more affordable and faster cell screening experiments for the areas of diagnostics and personalized medicine. Applications of the CellScreenChip include (but not limited to) cell based disease diagnosis (e.g. cancer diagnostics), drug screening (e.g. body on a chip) or personalized medicine (e.g. personalized drug compatibility tests). The CellScreenChip will be based on our recent development of the superhydrophobic-superhydrophilic micropatterning methods and the ability to create high-density arrays of droplet microreservoirs on superhydrophobic-superhydrophilic patterns that can be used for parallelized and miniaturized cell experiments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation'.

assistant: **Objectives**

The pathological alterations of neurological function (e.g., stroke, trauma, neurodegeneration, epilepsy, neuropsychiatric diseases, chronic pain) are commonly associated with alterations in brain rhythms and activity patterns. There is an urgent clinical need for treatments that can precisely control and restore neural activity, taking advantage of state-of-the-art technological developments in a variety of fields including nanotechnology, nano- and microelectronics, novel materials, brain science, clinical neurology, and computational modelling. META-BRAIN (MagnetoElectric and Ultrasonic Technology for Advanced BRAIN modulation) brings together seven expert partners in these fields with the aim of achieving precise spatiotemporal control of brain activity using magnetoelectric nanoarchitectures that can be polarized by non-invasive, remote magnetic fields. This novel principle of brain activity control will minimize the amplitude of the required magnetic fields, be wireless, and have enhanced spatial resolution from single neurons to cortical areas. We will develop a model-driven fabrication of the coils and monitor the effects on brain function with arrays of graphene microtransistors that uniquely allow full-band recording, integrating all elements in a closed loop. As an alternative to remote brain stimulation we will also use novel ultrasonic technologies. The META-BRAIN control paradigm will be systematically studied in pre-clinical systems from individual neurons to the full brain. All developments and experiments will be carried out in conjunction with theoretical models that will simulate, quantify, and predict optimal arrangements and patterns for the desired output. Translation to humans will be evaluated with our clinical partners, and a detailed disseminat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamics of modified chromatin domains' (DYMOCHRO).

assistant: **Innovation**

Cellular identity is defined by complex patterns of DNA and histone modifications, which partition our chromosomes and determine how cells interpret the genetic information. For cells to remember who they are, these modifications have to be tightly regulated over time and through cell division. Loss of cellular identity promotes different types of disease including neurological disorders and cancer.Histone modifications can spread along chromatin and can be transmitted through cell division, giving rise to chromatin position effects and cellular memory. However, the underlying molecular mechanisms are not understood. In particular, we do not know how the size and stability of modified domains is controlled, and we currently lack techniques to study these processes in real-time.Here, I propose to develop the single-molecule ‘chromatin curtains’ platform to directly visualize spreading and maintenance of histone methylation in a reconstituted system and to compare the resulting domains to those found on individual chromatin fibers isolated from cells. In a complementary approach, I will devise and set up a tunable synthetic circuit that installs and reinforces orthogonal epigenetic modifications in living cells to define the functional modules that are necessary and sufficient for chromatin position effects and cellular memory.My project combines molecular biophysics with synthetic biology to elucidate the fundamental principles that govern the dynamics of histone modifications to establish and preserve cellular identity. The chromatin curtains platform I will develop complements sequencing-based methods and will make it for the first time possible to directly assess the dynamics of histone modification patterns on single chromatin fibers under native conditions. I antici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced Magnetic Probes for Minimally Invasive Endovascular Surgery' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Endovascular interventions in minimally invasive surgery (MIS) are vital for treating cardiovascular diseases through small incisions. However, current manual and tendon-driven instruments lack precision. Magnetic actuation offers a groundbreaking solution, providing exceptional dexterity. The APOLLO project aims to develop a flexible probe capable of generating internal magnetic fields, revolutionizing MIS with advanced diagnosis and treatment options. Integrated sensors and biocompatible materials ensure precise control, meeting clinicians' needs in challenging anatomical regions. APOLLO's pursuit of commercial success involves strategic partnerships and dedicated business development efforts. In essence, APOLLO signifies a significant advancement in minimally invasive surgery, offering unparalleled precision and accessibility in treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Additive mass manufacturing of composite ceramic, metal and glass microparts and multilayers from nanosized particles using inkjet and laser technology' (1994-1998).

assistant: **Innovation**

Precursor materials:SiO2 and ZrO2 precursor materials were successfully developed to meet the specific needs for the process and the application. The development of suitable Al2O3 precursors for application on cemented carbides was not successful. The Ni/ZrO2 precursor for making electrically conductive layers was not laser-sinterable. An Ag-based precursor material proved to be a suitable alternative.Ink-jetting:Several of the SiO2 and ZrO2 precursor materials were successfully formulated into ink-jet inks suitable for printing on non-porous substrates. Concept inks with limited pot-life were made for the Al2O3 and Ni/ZrO2 sols. The print heads were modified to handle the aqueous inks developed in the project. The print head was adapted to print smaller droplets for fine line (60µm) applications. Lines and areas (2D) could be applied on steel and fused silica substrates using the inks developed. An electronic tool to run the OEM print-heads was developed and is now a commercially available product.Sintering:Laser-heating processes, specific for each substrate, were developed to sinter the precursor layers. Laser-sintering was successful for all precursors on fused silica (except the Ni/ZrO2). Several ZrO2 precursors could be laser-sintered on steel. Sintering of the Al2O3 precursors on cemented carbides was not successful. An analytical temperature model for laser heating was developed.Equipment:A demonstrator was built to run the Acerlink process on pilot scale. Accurate printing is possible, but integration of the other technologies was not yet achieved.Applications:Friction-reducing layers could be made by the Acerlink process on steel substrates. Well-conducting lines and areas could be made by laser heating. Multi-layer structures and composites could be made by l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Domestic structures and european integration. a multi-stage two-level analysis of constitution building in the european union'.

assistant: **Objectives**

This project will study constitution building in the European Union using a multi-stage two-level-analysis of the Intergovernmental Conference (IGC) to be concluded in 2004. We wish to answer two main questions: How is the process of constitution building carried out? How can we explain the outcome of this process? Our project will relax assumptions on unitary member-state preferences and one-shot processes of constitution building. We will examine the preparatory stage of inter-ministerial coordination, the negotiation stage at the IGC, and ratification in member states. We expect that the more non-unitary a member state government is, the more likely is an IGC agreement. However, we expect that when more alternatives for an agreement exist, their successful ratification is more endangered. Using a multi-pronged data gathering strategy, we will test these hypotheses and assess the two-level character of EU constitution building.