RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Brain organoid-on-chip: a microfluidic platform to study neocortical development' (BROOC).

assistant: **Innovation**

A human model of neocortical development to understand neurodevelopmental disorders such as autism spectrum disorders or intellectual disability is urgently needed. Neural 2D cultures derived for example from induced pluripotent stem cells (iPSC) have been used for many years but lack the complexity of the tissue environment essential for the functionality of the developing neocortex. A promising approach to provide controlled microenvironments that generate physiological conditions and allow controlled 3D spatio-temporal structuring is the use of Organ-on-chip (OoC) technology. This BROOC proposal aims to establish a new generation of Brain Organoid-on-Chip. To study neocortical development and test pharmaceutical interventions, this project will construct new cerebral organoid model with multi-layered cortical structures on microfluidic chip system within integrated electrode array. Moreover, the Brain Organoid-on-Chip platform has the potential to transform the field and will have many applications especially for studying neurodevelopmental disorders. By overcoming several drawbacks of currently available cerebral organoid models, it will impact on the emerging field of organoids in general spanning from organoids used as alternative methods for animal experiments to cerebral organoids generated from diverse species used as a tool to study the molecular mechanisms of brain evolution.


**Keywords:** organ-on-chip, brain organoid, 3D cell culture, hydrogel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Plug-and-play sustainable dyeing solution to help the textile industry reduce energy costs and environmental impact'.

assistant: **Objectives**

Textile and fashion brands face mounting pressure from national and international policies, consumers, and institutional investors to transform their practices and decrease greenhouse gas (GHG) emissions. Presently, textile dyeing methods are both energy-intensive, resulting in higher GHG emissions, and economically burdensome. Although sustainable dyes can reduce GHG emissions, they often come at a higher cost due to expensive materials, additional capital investments, or the need for high temperatures, leading to elevated energy expenses.Ever Dye has pioneered an innovative dyeing process with a biosourced pigment, effectively detoxifying the textile industry, diminishing GHG emissions, and significantly reducing energy costs by enabling dyeing at room temperature. This breakthrough allows dyeing houses and fashion brands to achieve substantial savings while adhering to the growing demand for emission reduction across the textile value chain.Ever Dye has already made considerable headway in the market and intends to carry out laboratory and industrial trials in partnership with several prominent fashion brands.


**Keywords:** textiles, fashion industry, sustainability, GHG emissions, dyeing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Design Principles in Late-Gothic Vault Construction - A New Approach Based on Surveys, Reverse Geometric Engineering and a Reinterpretation of the Sources' (REGOTHICVAULTDESIGN) under Seventh Framework.

assistant: **Objectives**

The project is dealing with the study of the design of Late Gothic vaults by correlating the existing knowledge with surveys performed on existing structures. The aim is to gain a better understanding of how the design of these highly complex structures was performed, searching in particular for a possible connection between geometric design of the vaults, structural design and architectural proportion systems.While until now the knowledge is mainly based on sources and in some aspects appears inconsistent, the innovative approach of the project consists in formulating hypotheses on the design directly from the built artefact, with a working method not common in surveying until now.On this background, the current interpretation of the sources will be revised. Moreover, a relevant but still underestimated source will be edited and studied. The methodological problems regarding the interpretation of the geometric features of surveyed buildings and the interpretation of design processes in architecture will be discussed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CONCURRENT ENGINEERING WORKFLOW' (CONFLOW).

assistant: **Innovation**

The project has two major objectives:- The development of a fundamental approach to dynamic linking workflow design and execution to product structures to achieve product-object driven workflow management functionality for concurrent engineering;- The application of autonomous knowledge acquisition techniques to obtain intelligent workflow management functionality for recurrent engineering tasks.In the engineering domain the product structure fixes the tasks which have to be performed to achieve a certain goal. The product components (objects), their characteristics (attributes) and their relationships within assemblies (interference) determine the planning and operational processes needed to manufacture an optimal product in terms of price, time to market and quality. Therefore, reference processes have to be defined at the component level that describe which workflows (activities and work items) within the product and process definition have to be conducted according to the component attributes. At the assembly level, the relationship between the components has to be represented in order to assess the interdependence between the reference processes at the component level. The process definition module of the workflow management system has to be enabled to connect the reference processes with the product structure. Modifications in the product structure must automatically result in adapted process definitions. According to the resulting design, the workflow management system executes the workflow, manages the engineering work units involved, provides them with the required data and, in this way, establishes efficient concurrent engineering.In order to achieve a dynamic link between the product structure and the workflow design, rules are required which adapt the workfl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Disentangling Cross-Scale Drivers of Coral Reef Fish Community Structure for Ecosystem-Based Management' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Ecosystem-based management is the dominant paradigm for species-rich, but data-poor coral reef fisheries. But its operationalisation is hindered by a lack of information on the natural organisation of coral reefs as determined by distinct biophysical processes operating across scales in space and time, and therefore how that organisation is affected by local human impacts. Understanding how natural and human drivers interact to determine ecological organisation is critical to the local, context specific and spatially explicit application of ecosystem assessments for management, such as prioritizing management areas based on recovery potential and degree of depletion from an unimpacted baseline state. FISHSCALES not only addresses that knowledge gap, but for the first time proposes a unique natural experiment of unprecedented scale with a novel combination of trait-based approaches and high-resolution oceanographic modelling to reveal the relative influence of interacting biophysical environmental drivers and local human impacts on the functional structure of reef-fish communities across scales (from reefs to regional). Using existing multidisciplinary data spanning 45° of latitude and 65° of longitude across 39 central western Pacific islands, this project will use predictive models to identify the natural biophysical mechanisms that best explain the spatial variation of reef-fish functional diversity across scales. It will then model how local human impacts disrupt those biophysical relationships, and explicitly quantify the relative impact of different human disturbances (from fishing to coastal development). Collectively, the results of FISHSCALES will advance our capacity to predict spatial patterns of functional diversity and structure of reef-fish communities, pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Integrated mesoscale-hydrometeorological modelling for rainfall and flood forecasting.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The research aims to produce a simple, physically-based rainfall forecasting model capable of being coupled with catchments or urban scale hydrological models for the purpose of flood forecasting, and capable of being adaptive to the variety of storm types experienced across Europe. It is anticipated that this can be achieved by further developing an existing rainfall forecasting model and doing so through a case study methodology. Having already tried and tested the model with respect to storms crossing the United Kingdom, the focus in this project is to improve its competency with respect to heavy precipitation events in Mediterranean regions and where complex terrain strongly influences storm development. Catalonia, Spain, is the proposed location for the case study and the model will be subjected to a series of storms observed in the region in order to examine its behaviour and identify weaknesses in its forecasting. Improvements will be sought by maximising the information extracted from remotely sensed data and Numerical Weather Prediction Model forecasts of standard atmospheric variables. Upon being satisfied with changes made to the model, the case study will be completed by assessing the performance of the final version" with a new set of storms from the same region. The proposed research is a natural progression from the work undertaken in the European Commission funded HYDROMET Project (Contract no: ENV4-CT96-0290), the aim of which was the development, of active on-line hydrological and meteorological models to minimise the impact of flooding."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Reliable Vulnerable Road Users Behaviour Prediction Considering Spatiotemporal and Socialized Interactions' under Horizon Europe.

assistant: **Concept**

As a connection module between the perception layer and decision-making control layer of autonomous vehicles, behaviour prediction is one of the research focuses in this field. The existing behaviour prediction technoAs a connection module between the perception layer and decision-making control layer of autonomous vehicles, behaviour prediction is one of the research focuses in this field. The existing behaviour prediction technologies have the problems of unclear spatiotemporal interaction coupling mechanism and socialized interaction mechanism between the target object and environment, which makes it difficult to achieve accurate behaviour prediction and seriously restricts the practical application of this technology in the field of autonomous vehicles. Aiming at complex high-load mixed traffic flow scenarios, this project takes Vulnerable Road Users (VRUs, e.g. pedestrians, cyclists, etc.) as the research objects, and conducts research on the theories and key technologies of behaviour prediction driven by spatiotemporal and socialized interactions. The content includes: VRUs-vehicle coupling mechanism investigation in spatiotemporal domain and spatiotemporal interaction modelling; VRUs-vehicle socialized mechanism study in social psychology aspect and adaptive socialized interaction modelling; synergistic driven mechanism study in multi-model integration field and dynamic ensemble learning modelling; and validation and optimization of VRUs behaviour prediction models. The vision of ReSIN is to develop an accurate, interpretable and robust/resilient VRUs behaviour prediction model for AVs to behave safely, efficiently and confidently under complex and uncertain traffic environments. By empowering AVs with this prediction capability, ReSIN will enable a seamless inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Antigen presentation and T cell-mediated immunity: membrane trafficking in cross-presentation' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Cross presentation is the process by which professional antigen presenting cells (APCs) present phagocyted antigens in the context of MHC class I molecules (MHC I), to prime CD8+ T cells. Recent findings have revealed that this process takes place in a spe cialized, ER-phagosome mix compartment in the major APCs, like dendritic cells (DCs) and macrophages. This novel compartment was also shown to be self-sufficient for cross presentation. In this context, ER membranes are recruited to the forming phagosome and contribute to peptide translocation and loading on MHC I within phagosomes. Internalised antigens are partially degraded before translocation to the cytosol and processing by the proteasome. Processed peptides are then returned inside phagosome to be loaded on MHC I molecules. Peptide loaded MHC class I molecules then reach the plasma membrane where CD8+ T cells recognize them. Despite the evidences of ER contribution in phagocytosis process, the molecules responsible for ER-phagosome fusion remain unknown as well the origin of the MHC class I molecules involved in cross presentation is still unclear.Our aim for this proposal is to elucidate the components of the molecular machinery involved in ER-phagosome fusion and to analyse the trafficking of MHC I molecules during cross presentation. SNAREs and Rabs are two protein families involved in membrane trafficking and fusion. We have observed the presence of the ER SNARE Sec22 and the plasma membrane t-SNAREs syntaxin3, syntaxin4 and SNAP23, as well Rab1 and Rab2 on purified phagosomes from D1 dendritic cells. These data suggest that some of them could be involved in ER-phagosome fusion. We will directly address this possibility using both in vivo and in vitro approaches, such as silencing protein production utilizi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Measuring Illegal Online Pharmacies' Impact and Co-evolution' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The pharma analytics market reached $60B in revenues in 2021 and is expected to grow at a 20% annual rate in the coming years. The data and business intelligence provided by pharma analytics companies around drug sales is of outmost importance for multiple stakeholders in the pharma industry (e.g., manufacturers, distributors, and regulators), who rely on this data for their decision-making. However, this data is becoming increasingly biased and myopic: it only accounts for drug sales from legal pharmacies, overlooking sales from illegal pharmacies. This limitation is becoming more and more problematic since sales from illegal pharmacies (mainly operating online) are growing at a substantive pace. The goal of this PoC is to address this limitation through the development of a web service that will provide data and business analytics on drug sales by Illegal Online Pharmacies (IOPs). This web service will allow potential users to visualize market trends, download data, and develop customized reports on IOPs The goal of this PoC is to develop a web service API that will provide data and business analytics on drug sales by Illegal Online Pharmacies (IOPs) through a web portal. This web service will allow potential users to visualize market trends, download data, and develop customized reports, and will be provided following a pay-per-use commercial structure. While multiple stakeholders in the pharma industry are potentially interested in this data (e.g., manufacturers, distributors, pharma analytics companies, policy-makers, and law enforcement authorities), this data is currently unavailable due to the obscure nature of IOPs’ activities. The web service proposed in this PoC will generate such data through the algorithms designed in the ILLEGALPHARMA ERC-funded project. A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The first Total Artificial Heart (TAH) that truly mimics the human heart and has the potential to revolutionise the market'.

assistant: **Concept**

The Realheart TAH system (RTS) is the first total artificial heart designed to mimic the structure and function of the human heart. Its unique patented construction of two atria and two ventricles is separated by an atrioventricular plane which contains the valves, enabling to pump blood naturally whilst reducing the risk of blood flow complications. RTS is designed to be efficient (12h battery), silent, lightweight (2.5kg), easy to implant and automatically adapt to different (physiological) activity levels. It consists of two identical artificial heart pumps, a drive line and an intelligent control unit. RTS is connected via a cable through the skin to a controller carried together with two batteries in a belt around the waist. RTS is aimed as a permanent solution for end-stage heart failure patients, but also for patients waiting for a transplant. Realheart will complete GLP animal trial, clinical trial preparatory activities and first-in-man (EFS) trial during the EIC project.


**Keywords:** Total artificial heart,Cardiothoracic surgery,Congestive Heart Failure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hazard analysis and control of food contamination : prevention of fusarium mycotoxins entering the human and animal food chain' in the context of a Fifth Framework call.

assistant: **Objectives**

In Europe wheat, barley and maize are significant components in food and feed processing. Fusarium moulds have become a serious problem because they produce a range of toxic metabolites (mycotoxins) which endanger the health of both humans and animals. This project will integrate Hazard Analysis with a range of control strategies for the prevention of these fungi and their mycotoxins entering the human and animal food chain. By identification of the critical control points in the food chain using HACCP and intergration of this with preharvest biocompetitive methods, post-harvest control using natural and novel food-grade preservation systems, and decontamination strategies using microbial and physical methods, entry into the food chain will be prevented. The commercial exploitation of the technologies will be examined in collaboration with end users. This trans-european consortium includes partners in UK, Finland, Holland, Spain and Italy.