RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'stable Isotope Study of bone and dental remains: Hydrogen and Oxygen methodological Developments'.

assistant: **Concept**

The study of the interactions between ancient societies and their environment is a key element to decision-making in the global context of climate change. Stable isotope analysis of biological (bone and dental) remains provides insights into climatic conditions, dietary habits and geographical mobility of modern and past populations. The ISHOD project sets up to refine the analysis and interpretation of two proxies: the hydrogen (d2H) and oxygen (d18O) stable isotope compositions of animal and human remains from modern and archaeological contexts.Traditionally, d2H and d18O values are respectively measured on distinct matrices (bioapatite for d18O and collagen for d2H). Both proxies face analytical (atom exchange during pretreatment procedures) and interpretative (what information are recorded) challenges. ISHOD aims to develop (1) d2H measurements of bioapatite and whole bone and (2) d18O measurements of collagen. Once operational, protocols and setups will be used to explore how d2H and d18O values compare with other isotopic systems (C, N, S, Sr) and record climate, diet and geographic origin. They will be applied to investigate the medieval city of Ieper (Western Flanders, Belgium).I will be hosted at Vrije Universiteit Brussels and supervised by Prof. Christophe Snoeck, a renowned expert in bioarchaeology specialized in isotope analysis of animal and human remains. During the fellowship, I will be trained to improve my scientific (stable isotope facility operating, pretreatment expertise) and interpersonal (leadership, networking) skills. ISHOD will lead to new chemical procedures and analytical setups to perform d2H and d18O measurements, which will advance our understanding of how ancient European societies experienced and adapted to climate changes. The projects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Software-defined Edge Computing Solution' (ONEedge).

assistant: **Concept**

So many companies now, both long-established and newly emerging, from multiple industries like gaming, the Internet of Things (IoT), social networking and telecommunications, are focusing their business strategies on being able to provide innovative services and capabilities where latency is the key factor for quality of experience. Yet, despite the urgent need to define the foundational platform to deliver services at the network edge, at present, the companies that are developing next-generation solutions simply do not have a viable and cost-effective platform on which their low latency applications can become mainstream. Existing edge platform solutions require building and maintaining extremely heavy, expensive and complex deployments. Our innovative product, ONEedge, will provide an automated software-defined platform to build private edge computing platforms based on resources leased on demand in close proximity to the users and devices. A first prototyped version of the product is publicly available, and has been successfully demonstrated in several industrially relevant environments. We have existing customers interested in using this innovative product. The aim of this project is to bring ONEedge to industrial readiness and maturity for market introduction. ONEedge is targeting an untapped business opportunity, estimated at $2.0 billion by 2022 and expanding at a CAGR of 115%, by using an easy-to-adopt innovative business model fully based on open-source software and support subscriptions. OpenNebula Systems is an international business with a 23% compound annual growth rate in the last 4 years and seasoned experience in developing and bringing to market open-source enterprise products. Our conservative financial projection for the project shows a 50% Internal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development, dIagnostic and prevention of gender-related Somatic and mental COmorbitiEs in iRritable bowel syndrome In Europe' (DISCOvERIE).

assistant: **Innovation**

Mental (anxiety and depression) and non-mental (fibromyalgia and chronic fatigue syndrome) comorbidities are highly prevalent in irritable bowel syndrome (IBS), with over 60 million Europeans affected, mostly women, by devastating manifestations, impaired treatment and quality of life. Estimated costs are €43 billion/year for IBS, mostly derived from comorbid IBS. Our hypothesis is that comorbid IBS represents a distinct clinical entity, arising from distorted brain-gut communication with a unique, specific, but undefined pathophysiological origin, differing from IBS alone. DISCOvERIE was created to advance the understanding of its causative mechanisms. Identification, validation and comprehension of these mechanisms will help stratify these patients into distinct clinical phenotypes, improving disease management, increasing quality of life and reducing socioeconomic costs. In particular, we will deliver specific comorbid-IBS physiopathological knowledge as clinical guides and protocols for newly created, hospital-based, transversal and multidisciplinary units for implementing personalized management and wellbeing of European citizens and to position Europe as a global leader in comorbid IBS personalised medicine. We will also deliver prognostic and therapeutic biomarkers and patents, technological innovation via e-health tools for personalized assessment of clinical/nutritional/physical activity and disseminate new knowledge widely. Impact will be assessed by recording media presence, scientific publications and by monitoring health-related quality of life of patients and promoting cost-effective care. To this end we have created a user board involving patient associations, clinical specialists, European healthcare experts, large pharma and SMEs representatives. We wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Isaac Newton Institute for mathematical sciences Marie Curie conferences and training courses, Framework 6 series two' under Sixth Framework.

assistant: **Concept**

The INIMS is an international research institute of outstanding reputation, covering the broad spectrum ofmathematical sciences. From 2005 to 2008 the Institute will hold a number of interdisciplinary programmesduring which Marie Curie Conferences and Trai ning Courses will take place. Those programmes approved todate for that period are Model Theory and Applications to Algebra and Analysis, Developments in QuantitativeFinance, Pattern Formation in Large Domains, Global Problems in Mathematical Relativity, P rinciples of theDynamics of Non-Equilibrium Systems, Logic and Algorithms, Spectral Theory and Partial Differential Equationsand Noncommutative Geometry. These and future programmes cover a large part of the science and technologyareas forming the seven th ematic priorities of FP6.Mathematics is a vital underpinning tool across all sciences of immense importance, and conferences held at theNewton Institute will encourage the development both of basic science and of new mathematical techniquesrelevant to esta blished scientific areas. A common theme of all these Newton Institute programmes will be theways in which mathematics is an essential component of scientific advances, in particular in priority areas for theEC.The objective is to ensure that the work of t he Institute, focussed in a theme at the conferences, is disseminatedmore widely in the European Community, and that more young people from across that community are given theopportunity to participate in workshops and seminars in a wide range of mathemati cally-related sciences. TheMC Conferences and Training Courses are linked by the fact that they all explore an important topic at thecutting edge of the mathematical sciences but it is expected that different scientists will attend each event andhence a la r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'LIPOFABRIK: A ground-breaking biomolecular production platform for safer, more efficient and sustainable pest control and crop health management.' (LIPOFABRIK) under Horizon 2020.

assistant: **Objectives**

Plant pathogens are a major threat to feed and food production, being responsible for the loss of over 40% of the world food produce. Also, feed and food contaminated with microbes or their toxic by-products is banned from the market and lift trade barriers. Producers rely on plant protection products to fight pathogens, but since most of them have chemical origin, their use entails major risks. Along the hazard for the exposed applicators, chemical residues contaminate soil, water, plants and their products, posing a major threat for consumers and livestock. To reduce these risks, authorities are banning many chemicals from their use in plant protection, leaving the market with no effective alternatives. In response, we at LIPOFABRIK have developed and patented a suite of innovative biopesticide molecules of biological origin, lipopeptides. Our biopesticide molecules are effective and eco-friendly, with proven protective properties that spare plants from damaging agents, but also prevent the deposit of residues or contaminants. Today, we are able to produce and commercialize our lipopeptides at a small scale, but the need for lipopeptides in agriculture, seed protection or gardening reaches up to several hundreds of tonnes per year. This need is not being met today. Thus, the ultimate objective of this project is to optimise our technology and achieve the industrial capability to cover the market need. To achieve this goal, in Phase 1 we will conduct a Feasibility Study to help us gather input on the main technical, commercial and financial aspects influencing the project. Once completed, our project will bring significant benefits for agriculture, environment and society. It will supply safer, non-toxic and effective biopesticides, reducing the incidence of poisoning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cells and giant viruses: a win-win co-evolution' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The discovery of Mimivirus, the first icosahedral virus visible by light microscopy, was followed by the characterization of many other relatives. Its aquatic relative Megavirus chilensis, has a 1.2 Mb genome and encodes more than 1000 proteins, 2/3 unique to the Mimiviridae. Their infectious cycle is cytoplasmic. During the last 10 years, my laboratory discovered three other giant virus families: -the pandoraviridae, with their unique amphora-shaped 1m long virion morphologies, genome sizes reaching 3Mb and encoding thousands of proteins, most of which without homologues in the cellular or the viral world  the mollivirus, which was isolated from a 30,000 years old Siberian permafrost sample, presents common features with the pandoraviruses. They share 60 unique genes and the roughly spherical (0.6m) mollivirions present an external tegument resembling the pandoravirions. Both viruses have an early nuclear phase  the pithovirus, despite its amphora-shaped virions, has a fully cytoplasmic cycle. Our work raised questions on the origin of these intriguing viral families and their position in the tree of life.  My project is unique as it will address the coevolution of these viruses and their amoebal hosts by focusing on specific features of the virions in two overall aims. 1) Promising preliminary results led us to hypothesize that a progressive transition from the rigid icosahedral virions to the more plastic amphora-shaped particles was made possible through hijacking of the host cellulose synthesis pathway by the ancestor of pandoraviruses. 2) The icosahedral mimivirus package its genome in a complex rod-shaped structure. My team will investigate this structure to unveil possible evolutionary links with the genome packaging systems in the cellular world. We will charac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AGeing effects on human aORta: from shApe to flowS' to be submitted under Horizon 2020.

assistant: **Abstract**

Age-related remodeling of the aorta is associated with alterations in morphology and hemodynamics . These alterations are involved and accelerated in the presence of cardiovascular diseases (CVDs), suggesting that they are the likely culprits that underlie the increased cardiovascular risk associated with ageing . However, an advanced characterization of the age-related morphological/hemodynamic alterations and on their synergistic interplay is missing, mainly because encumbered by time-consuming operator-dependent tasks. In this 36 months global fellowship (University of Toronto, Canada and Politecnico di Torino, Italy), the potential clinical utility of such a characterization will be addressed, developing tools for the quantitative assessment of the age-associated alterations in a large-scale cross-sectional dataset of aortas from subjects with successful ageing. After training on phase-contrast magnetic resonance imaging (PCMRI) technique, for each subject the 4D velocity field will be acquired. Quantitative morphometric parameters will be defined and evaluated in vivo. To investigate aortic hemodynamics, PCMRI will be complemented by computational fluid dynamics (CFD) to overcome PCMRI limitations on temporal/spatial resolution and wall shear stress quantification . The impact of CFD assumptions will be assessed by validating CFD results with PCMRI measurements. To improve CFD results accuracy, in the return phase PCMRI data will be incorporated into the numeric simulations, through the assimilation of the acquired flow fields into the CFD solver. Descriptors quantifiable in vivo and able to simplify the understanding of the complex 4D hemodynamic and of age-associated remodeling will be defined. The new tools for diagnostic/prognostic purposes will be integrated w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MILD Combustion with Nitrogen and Carbon Dioxide Reforming', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Reduced net emissions of carbon dioxide (CO2) are necessary to achieve the goals of limited global warming and ensure a sustainable future for our society. This proposal presents a versatile and scalable process for management and valorization of CO2 and nitrogen. Starting from biomass residues, a first step in the proposed scheme involves a pyrolysis process that results in the release pyrolysis oil of rather low heating value. However, combustion under very diluted conditions using a Moderate or Intense Low-oxygen Dilution (MILD) concept allows for efficient and low-pollutant energy conversion. The MILD combustion process is utilized for a CO2 reforming step resulting in generation of syngas. The pyrolysis and the reforming are supplied by heat from the MILD combustion that can be further supplemented by intermittent energy sources such as solar and wind power. The residual char product from the pyrolysis step can be upgraded by activation with CO2 and utilized for adsorption of nitrogen from biomass. The nitrogen-enriched char can then be used for soil carbonization and nitrification. The concept thus addresses the objective of CO2 and nitrogen management with efficient renewable resource deployment. It also adopts a circular approach as it can employ biomass residues as raw material and combines the production of heat and syngas with that of porous biochar materials for several possible utilizations. The process can be adapted by multiple parameters and optimized for different conditions and purposes, and rather than optimizing on a single product or aspect, the concept brings a holistic view. The development of the process will include experimental research with state-of-the-art analysis methods, based on laser diagnostics and neutron scattering, combined with nume
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'An expert system for optimal insertion of intensified energy saving technologies in the industrial processes' to be submitted under Fourth Framework.

assistant: **Abstract**

The competitiveness af the European process industry is mainly determined by its ability to improve the efficiency of the existing processes Existing plants also means limited place for process extension as well as more 5tress from the environmental constraints. Offering more compact and more efficient unit operations that are usually more environment friendly, the intensified energy saving technologies (IEST) are in good position to tackle the problem. A major problem remains unsolved : their ability to fit into existing processes. This concerns the potentia} of application of the IESTs, the determination of their proper sizing and of their conditions of optimal insertion in existing processes including their possible synergies. To answer these needs, the objectives of the project are 1) to set up an IESTs data base including all the data needed to compute and evaluate their insertion in existing processes; 2) to develop a scientific process analysis method aiming at the identification of the potential application of the IESTs; 3) to develop, for each IEST, an algorithm to determine the proper sizing when inserted to a given process; 4) to develop an evaluation methodology for computing the break even points of the technologies with respect to the environmental constraints, the energy savings, the investments and the operating costs; 5) to compare with the help of the tools developed the insertion of the IESTs to the one of classical technologies in industrial case studies in order to determine the potential of application of the IESTs in the European industry. The definition of the optimal insertion of IEST in existing industrial processes requires different tasks to be performed: 1. Charaterize the IESTs by constituting IESTs data bases in the field of heat transfer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'IRON CHELATOR NBMI FOR THE TREATMENT OF IRON OVERLOAD IN BETA-THALASSEMIA MAJOR' (Chelator).

assistant: **Innovation**

β-thalassemia major (βTM) is a lethal orphan disease with genetic background, diagnosed in infancy and requiring recurrent blood transfusions to prevent malformations, assure acceptable quality of life and prolong patient’s lifetime. Constant transfusions are related to severe adverse effects due to the resultant iron overload, including severe impairment of internal organs’ function and heart disease, with cardiac complications causing over two thirds of deaths in βTM patients. Life-long, effective iron chelation therapy is the only measure to reduce these risks, but available chelators have low efficacy and tolerability and/or complicated administration route. Together with high costs it hampers compliance, reducing the efficacy of available chelators even more and leaving unmet the need for safe, effective and easy to use iron chelator.Emeramide is an efficient metal chelator shown to decrease iron levels in vitro and in vivo, with a huge advantage of safety already confirmed in clinical trials up to Phase 2a. The drug has been recognized by the US and the EU authorities and received Orphan Drug Designation for mercury toxicity treatment. Thanks to its great tolerability Emeramide promotes high compliance with chelation therapy, making patients’ lives not only longer, but also as close to normal as possible.