RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Endoscopic access to the feto-placental unit: from animal experiments to clinical applications' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

To develop safe and performing instruments or devices for intra-uterine endoscopic fetoplacental interventions, including new small diameter optics, amniotic distension and coagulation devices. fibre-optical monitoring devices and techniques for chronic catheterisation and aminiotic sealing. tested in animal experiments and where applicable validate it in man.To set up a register of operative fetoscopies which will allow to bridge the gap between actual investigational procedures and routine established clinical practice.The unborn foetus has become a patient to whom diagnosis and therapy is offered prior to birth. Occasionally invasive procedures are needed for foetal diagnosis and therapy For diagnostic purposes, only seldom fetoscopy, being the insertion of an endoscope in the amniotic cavity is needed, since ultrasound resolution has improved so much. Ultrasound today is also used to guide invasive procedures, such as needle insertion to sample fetoplacental tissues. or to inject substances e g intra-uterine transfusion In some rare conditions the foetus needs to be operated on during its intra-uterine life. Foetal surgery actually requires maternal laparotomy hysterotomy, and temporary exposure of the foetus. Such a procedure is unfortunately associated with poor foetal outcome while being very invasive to the mother.More recently fetoscopy has been revived to operate on the foetus and placenta, which opened new perspectives for foetal medicine Minimal invasive endoscopic procedures do not require exteriorisation of the foetus, who can so be maintained in its natural environment. This is associated with less foetal and maternal morbidity Some clinical procedures, such as laser coagulation of feto-placental vessels, or cord ligation, have gained acceptance and saved
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Exploring the interface between cell metabolism and gene regulation: from mRNA interactomes to ""REM Networks""""' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The question of how (intermediary) metabolism and the regulation of gene expression are inter-connected represents one of the central challenges for the next decade of research. This proposal aims to take a decisive stab at this question, exploiting hidden gems from the literature and modern day technologies.Some metabolic enzymes have been caught “moonlighting” as RNA-binding proteins and, intriguingly, their RNA-binding activities appear to be under the control of metabolites and/or cofactors of these enzymes. Moonlighting enzymes could thus act as metabolite-controlled RNA regulators in RNA-enzyme-metabolite, or “REM” networks, imposing post-transcriptional influence on gene expression in metabolite-dependent ways. The riboswitches found in bacteria offer a precedent for how metabolites can have a direct effect on RNA metabolism.Within this proposal, we describe how we plan to uncover “all” the mRNA-binding proteins (the mRNA interactomes) of eukaryotic cells in vivo, a feat which would have been impossible until recently. Following the determination of the mRNA interactomes of yeast and three strategically chosen mammalian cell lines, we will focus our follow-up analyses on the RNA-binding enzymes of intermediary metabolism of these interactomes: decipher their bound RNA targets, learn how different metabolic states and metabolites affect the RNA-enzyme interactions and, most importantly, establish the physiological importance of the studied REM networks.The determination of mRNA interactomes will generate an unprecedented resource for the RNA biology community. We undertake this work with the motivation to uncover a key principle of how metabolism and gene expression may be connected, opening a new field of investigation for different disciplines in biomedical rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Social Intergration by Transitional Labour Markets: New pathways fo r Labour Market Policy' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The research project aims at: Developing a theoretical analysis supported by institutional indicators of the nature of transitional labour markets to facilitate social integration, the types of transition which occur under different institutional arrangements, and performance indicators on an aggregate level for social integration and exclusion.The general approach would be to develop a socio-economic theory of institutional change and innovation supporting social integration and preventing social exclusion. In this framework it is foreseen: * To examine the transitions provided by flexible working time arrangements, in particular part-time work. Patterns of working time flexibility will be examined in relation to household structures, to understand how working time flexibility is related to changes in household composition and how this can prevent or encourage forms of social exclusion. Innovative methodological tools will be developed in order to allow for an integration of quantitative and qualitative methods. Cross national research will be developed to show how the mechanisms of social exclusion operate within the specific national institutional framework. * To evaluate active labour market policies in terms of their capacities to prevent social exclusion (especially through work sharing and job rotation policies) and to support social integration (especially through training policies and intensive placement services). Special emphasis will be given to the implementation and organisation of policies. The theoretical aim is to lay down the foundations for a new political economy of labour market policy merging possibly in a productive way the paradigms of new public management. * To establish why education and training systems fail to secure a sufficient level of ba
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'E-COMmerce Proficient Analytics in Security and Sales for SMEs' to be submitted under Seventh Framework.

assistant: **Abstract**

The SME E-COMPASS project offers real-time and on-demand web-based applications and services to SME e-commerce providers that they could not afford or do not have the business capacity for ordering customized applications from large IT and software providers.In an attempt to overcome time and scale limitations in these complex market conditions and threats for SME e-commerce providers, the SME E-COMPASS consortium proposes to design, develop and validate in SME business environments two real-time proficient applications that fosters online security and promotes e-sales , namely :1) Real-time Anti-fraud “Software-as-a-Service” with the following components: fully-functional web-based platform, a reputation database, a knowledge database (KDB).2) Real-time Data Mining “Software-as-a-Service powered by: semantic web technologies, linked data, an event processing engine and web-based visualizations and dashboards.Real-time anti-fraud aims at detecting fraud by analyzing financial transactions. Banks, retailers, credit card companies, telecommunications firms and many other organizations wrestle with this issue. The proposed anti-fraud service scores fraud predicting outcomes using data mining models. Transactions are analyzed as they occur within customer accounts. Once the normal mode of operations is understood capturing all previous transactions, unusual patterns and suspicious transactions are recognized.As the scoring model is limited by the memory and processing power of the machine on which it runs, the SaaS (Software as a Service) paradigm helps handling the massive computational requirements associated with analyzing customer purchasing patterns.The proposed platform can rapidly predict behavior at the transactional level and be part of an enterprise application fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pricing European transport systems' in the context of a Fourth Framework call.

assistant: **Objectives**

To inform the Commission on the current situation regarding the pricing of transport modes in member countries;to examine the degree to which this provides appropriate price signals in the light of all relevant internal and external costs;to forecast the consequences of moving to a more appropriate price structure and level, for road, rail, air and short sea shipping transport bearing in mind other likely developments affecting transport prices, and in particular further deregulation of rail and air services, as well as financial and other constraints. %Cross Channel Traffic; Transalpine Transport; the Finland - St. Petersburg and Oslo - Goethenburg route; Lisbon, crossing of the Tagus River; %QUITS, TRENEN, EUROTOLL and PETS form the joint Scientific Committee Other links with SORT-IT, MINIMISE, STEMM, SCENARIOS, OPTIMA and TRANSPRICE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Europiv 2 : a joint program to improve piv performance for industry and research' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Particle Image Velocimetry is a unique optical method to capture velocity fields in flows. It has been demonstrated in the EUROPIV 1 project. It is especially suited to hold the design of modern aircraft by consequently improving the performance of industrial wind tunnels. PIV provides much more information in much less time, giving a much deeper insight in the flow physics and saving large amounts of wind tunnel costs. Europe is at a leading position for the development of PIV toward industrial applications. The aim of the proposal is to push the development of PIV and to make it a real design tool for modern aeronautics. A joint approach of development, research and demonstration is proposed. Improvement of PIV for turbulence, near wall flows and vortices is looked at. Three demonstrations of Stereoscopic PIV in European industrial wind tunnels are planned. Research on future developments of PIV is performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional components of plasmodesmata - mediators in the process of virus movement' under Fourth Framework.

assistant: **Concept**

We plan to study the composition and function of plasmodesmata in relation to virus movement. The effects of a viral infection on the location and abundance of plasmodesmata associated proteins (PAPs), influenced by viral MPs, has not been studied. To this end, monoclonal antibodies specific for maize will be used as molecular probes to analyse plasmodesmal components. The goals of the project are: 1) identify maize PAP homologs in other plant species, 2) use PAPs as markers for altered plasmodesmal function following virus infection, and 3) characterize PAP function through cDNA cloning and sequence analysis. In this project, my work will be supported by an active collaboration between Dr. A.J. Maule and Prof. K. Roberts at the John Innes Centre. It will provide me with a unique opportunity to obtain training in new areas of cell biology, molecular biology and virology that will be invaluable in establishing a research career in France.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Triggering Haematological Adoptive T-cell Immunotherapy Strategies by HUnting Novel T-cell receptors'.

assistant: **Innovation**

Recent encouraging clinical results obtained with engineered T lymphocytes and increasing advances in the genome editingfield, have opened new opportunities for T-cell receptor (TCR) gene therapy as an immunotherapeutic approach for cancer.Unfortunately, the broad applicability of this treatment is still hampered by the possible mispairing of exogenous/endogenousTCR chains and by the limited number of high avidity tumor-specific TCRs. While the first issue has been successfullyaddressed by the hosting lab with the development a TCR gene editing protocol, the identification of novel tumor-specificTCRs is urgently required and this is the aim of my research proposal. We have the unique opportunity to combine the highlycomplementary expertise of the hosting lab in T-cell biology/genetic transfer and of the applicant on immune repertoiresequencing. We will target acute myeloid leukemia (AML) and hypothesize that by exploiting intrinsic features of AML (i.e.ability of AML blasts to differentiate into potent antigen presenting cells expressing tumor antigens), the functional fingerprintinduced by AML on tumor-reactive T-cells, and cutting-edge technologies (i.e. next generation sequencing; ligandomelandscape analysis), we will provide a comprehensive immunoprofiling of tumor-specific T-cells and isolate tumor TCRspecificities. Results obtained in this study will streamline TCR hunting studies in solid tumors, leading to the generation of aTCR library for different antigens and HLA restrictions, thus rendering TCR gene editing an innovative off-the-shelftreatment available for a high number of cancer patients. Awarding this fellowship will greatly enhance researcher’s careernot only by providing the opportunity to widen scientific knowhow and acquire new skills, but also by en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cellulose architecture systems biology for plant innovation creation' (CASPIC).

assistant: **Innovation**

Cell walls determine the industrial properties of a range of plant products, including paper timber food fodder and spun fibres, as well as coatings , enewable polymers, and future nanocomposites. The major bottleneck in the development of novel germplasm with new cell wall properties is our lack of understanding of the impact of specific genes on cell wall texture, that is the composite of cellulose microfibrils, CMFs, intercalated between matrix polymers, and on the impact of cell wall texture on industrial properties.The aim of this project is to develop the tools to rationally design plant cell wall properties for industrial end uses. A systems biology approach involving iterative quantitative modelling and experiments has been used to formulate a mathematical model explaining how cells determine wall texture. This mathematical model for cell wall texture formation is geometrical in origin and is therefore referred to as the geo model . It predicts all available cell wall textures given a number of parameters. In this project we will use a systems biology approach to test the function-based design capabilities of the geo model in two widely accepted model plants, Arabidopsis and the industrially important tree poplar. Transgenic plants with novel CMF and matrix gene assemblies will be produced and analyzed for changes in wall texture, chemical composition, and mechanical properties as related to industrial applications.The experimental output will be used as the experimental input in subsequent rounds of iterative modelling and experimentation aimed at fine tuning the geo model, and its associated industrial applications. This systems biology project is new at both the world and European level. and as such lies outside the FP6 thematic priorities. If successful this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'HIGH QUALITY AND COST-EFFECTIVE METAL AM POWDER FOR MANUFACTURING LOWER WEIGHT COMPONENTS WITH IMPROVED PROPERTIES FOR AIRCRAFT AND AUTOMOBILES' (Innopowder).

assistant: **Concept**

3D Printing, or Additive Manufacturing (AM) is a disruptive technology that produces light, high strength components (allowing a weight reduction of 40–60% in the engines, turbines, turbochargers, and structural parts) and novel complex geometries. In addition, 3D printing does not require tools, which means that component manufacturers consume less energy and raw materials. The problem is that raw materials used in 3D printers are conventional materials that have been adapted for 3D printing and they lack the specific technical properties required for aircraft and automobile components, and are also very expensive. Despite the potential benefits of 3D printing, the result is that the 3D printing production costs are prohibitively high in comparison to conventional methods, while the quality of the final components is worse. Innomaq21 SL is a Spanish SME that has designed an atomiser that uses a new technology that produces high-quality metal powders at lower cost. Therefore, INNOPOWDER is a high-quality and cost-effective metal powder for manufacturing transport components through 3D printers. INNOPOWDER has been designed and optimised by our material engineers and it has superior characteristics compared to the currently commercially available metal powders. Innomaq21 aims to use the SME instrument to scale up the production of INNOPOWDER and bring it to the transport market, achieving total profits of over 16M€ by 2024 and providing 36 new jobs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Positive Geometry in Particle Physics and Cosmology'.

assistant: **Objectives**

There are strong indications from physics at both infinitesimal and cosmic distances that our current understanding of the laws of nature is only approximate, and must be replaced by deeper principles. The UNIVERSE+ project seeks a new foundation for fundamental physics, ranging from elementary particles to the Big Bang, revealing a hidden world of ideas beyond quantum mechanics and spacetime. Novel geometric objects recently discovered in theoretical physics hint at new mathematical structures. Combinatorics, algebra and geometry have been connected to particle physics and cosmology in an entirely unexpected way. Leveraging these advances, we will launch the field of Positive Geometry, as a new mathematical framework for describing the laws of physics. To this end, we bring together the necessary expertise in particle physics (Arkani-Hamed, Henn), cosmology (Baumann) and mathematics (Sturmfels). This is the first collaboration of its kind, made possible by a recent confluence of critical insights in both mathematics and physics, which are now so closely aligned as to propel us forward on a clear trajectory. Our goals are fiercely ambitious: we aim to create a new mathematical language for describing physical phenomena at all scales, from the interactions of elementary particles to the large-scale structure of the universe.


**Keywords:** Scattering Amplitudes, Primordial Cosmology, Quantum Field Theory, Feynman Integrals, Computational Algebraic Geometry, Positive Grassmannian
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The first energy and cost-efficient disruptive ZLD Technology for dredged material management, allowing circular economy and zero pollution'.

assistant: **Innovation**

Dredging is an essential activity to maintain maritime and river routes, coastal protection to flooding, among others. Every year, over 2 Bm3 of sediments are dredged around the world, 20-40% of which are highly polluted and must be treated before being disposed to landfill (as current treatment and separation technologies do not allow to cost-efficiently valorise the water and the solids from this dredged material). Water Challenge has developed and patented the first energy-efficient truly Zero Liquid Discharge (ZLD+) technology able to separate 100% of dredged material into fresh water and crystalized solids in one step, without chemicals and with very low energy consumption (<20 kWh/m3).The aim of this project is to develop a pilot plant of 10 m3/day of capacity to separate and valorise the water and solids from dredged materials. This plant will be pivotal to showcase the technology and business model, before scaling it and replicating it around Europe.


**Keywords:** Coastal protection,Dredging,Design innovation,Ecology,Decontamination ,Water,Green technologies