RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Physiological roles of the Ribotoxic Stress Response' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ribotoxic stress response (RSR) surveys the structural and functional integrity of ribosomes and is triggered by diverse groups of ribotoxins (e.g. ricin), UV irradiation and some chemotherapeutics. When presented with impaired ribosomes, the proximal MAPKKK ZAK activates MAP kinases p38 and JNK to initiate a powerful inflammatory response. This signalling contributes to the detrimental reactions to ribotoxins and fatal side effects of cancer therapy. However, despite decades of research into the RSR, the physiological relevance of the underlying pathway in whole organisms is unknown. I hypothesize that the RSR constitutes a general translation quality control pathway and hence I aim to uncover the physiological and pathological implications of RSR impairment in mice and nematodes.In one line of investigation, I will elucidate the connections between UV radiation and RSR-mediated p38 activation. I hypothesize that this signalling pathway is critical for sunlight-induced skin inflammation and development of skin cancers of different cellular origins. Rewardingly, we found that cells from our ZAK knockout (KO) mice are refractory to UV-induced p38 activation, which is a significant contributor to skin cancer development. My team has also observed deregulation of protein translation in RSR-deficient human and mouse cells, and a reduced lifespan of ZAK KO nematodes. Thus encouraged, I will determine the impact of the RSR pathway on cancer development and aging processes in mice, and I will unravel the molecular connections between defective ribosomes, RSR activation and regulation of translation. Finally, I am in a unique position to evaluate the RSR as a putative drug target and I will investigate the potential of ZAK inhibition to treat or prevent skin cancer, and to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'More specific insecticides: harnessing knowledge of insect receptors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Pest control is a central component of agriculture. However, insecticides and agriculture can have an impact on ecosystems. Regulations have been taken in Europe to ban some insecticides, based on the possible threat they pose to pollinators. There is an urgent, unmet need for species-specific insecticides that are safe for non-target organisms. In the proposed proof-of-concept project, we aim at demonstrating that peptides specifically designed against neurotransmitter receptors can be potent at pest species without affecting beneficial species. During the previous ERC-StG project, we developed tools to obtain pure mammalian neurotransmitter receptors. We have adapted those tools for insect receptors, which are the most important insecticide targets. We here propose to use insect receptors for the selection of species-specific peptides. The peptide libraries will be designed by computational-guided mutagenesis and screened by yeast display. Within the project, we aim to secure a solid IP position on the technology platform we will build, in order to maximise the likelihood of success for a commercial endeavour. We will explore the market opportunity and regulatory pathway for subsequent product development,  in order to define a business model and implement early commercialisation steps.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Pollution and recivery of fish farm sediments'.

assistant: **Innovation**

In order to prevent interactions between fish farms and the marine environment showing adverse effects on economy (diseases, low quality) mitigation strategies are urgently needed). One promising strategy is the transfer of fish farms, which might relieve organically burdened sediment leading to improved production) There is, however a lack of information on the effects of these measures, i.e. in semi-enclosed and none-tidal systems. Therefore, a major goal of the proposed work is to characterise and model the change of the benthos at different study sites once the point source of organic enrichment, i.e. the fish farm, has been removed or established, respectively. Specific objectives should include documentation and quantification of the changes occurring in terms of biogeochemistry, benthos, and fish pathogens, and to develop a predictive model to optimise balance between biomass production and product quality.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'DNA recognition by drugs and proteins' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The DNAREC EST site will perform internationally leading research training in the area of recognition of DNA by synthetic agents and biomolecules (drugs and proteins), an area at the interface of chemistry and biology. This will be achieved through multid isciplinary training on projects each of which will involve chemists, biologists and biophysicists with a broad spectrum of complementary expertises which range from drug design and synthesis, through biophysical techniques to molecular biology. DNAREC wi ll train students in projects focused on the areas of drug-DNA recognition and protein-DNA recognition. 12-month trainees will study one area while 36-month trainees will study both. DNAREC will train four 36-month fellows and four 12-month fellows.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Polarity and Central-Symmetry in Asymptotic Geometric Analysis'.

assistant: **Objectives**

Asymptotic Geometric Analysis is a relatively new field, the young finite dimensional cousin of Banach Space theory, functional analysis and classical convexity. It concerns the {\em geometric} study of high, but finite, dimensional objects, where the disorder of many parameters and many dimensions is ``regularized'' by convexity assumptions.   The proposed research is composed of several connected innovative studies in the frontier of Asymptotic Geometric Analysis, pertaining to the deeper understanding of two fundamental notions: Polarity  and Central-Symmetry. While the main drive  comes from Asymptotic Convex Geometry, the applications extend throughout many mathematical fields from analysis, probability and symplectic geometry to combinatorics and computer science. The project will concern: The polarity map for functions, functional covering numbers, measures of Symmetry, Godbersen's conjecture, Mahler's conjecture, Minkowski billiard dynamics and caustics. My research objectives are twofold. First, to progress towards a solution of the open research questions described in the proposal, which I consider to be pivotal in the field, including Mahler's conjecture, Viterbo's conjecture and Godberesen's conjecture. Some of these questions have already been studied intensively, and the solution is yet to found; progress toward solving them would be of high significance. Secondly, as the studies in this proposal lie at the meeting point of several mathematical fields, and use Asymptotic Geometric Analysis in order to address major  questions in other fields, such as Symplectic Geometry and Optimal transport theory, my second goal is to deepen these connections, creating a powerful framework that will lead to a deeper understanding, and the formulation, and resolution, of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Bifunctional and regeneratively active biomaterial: Towards an ultimate solution for osteoarthritis treatment'.

assistant: **Innovation**

Osteoarthritis (OA) is the most common form of arthritis of the joints, affecting over 70 million EU citizens. At present, no cure for OA is available; only symptomatic therapies may help to ameliorate this painful disorder. OA affects the integrity of the cartilage and progresses to an increased damage in its surrounding tissues, inclusive bone, and to inflammation of the synovial tissue. The latter reaction is caused by an accumulation of bone splinters. The therapy of choice would be – if available – bidirectional: first, regeneration of the damaged cartilage (by implants) and second, dissolution of the bone fragments (by injections). This proposal presents for the first time this two-fold solution. Within my ERC Advanced Grant “BIOSILICA” (No. 268476) we disclosed that biosilica elicits morphogenetic activity in cells involved in connective tissue formation. The effect of silica is augmented by another natural inorganic polymer, by polyphosphate (polyP), which is synthesized in most animal cells, especially blood platelets that accumulate in damaged bone and cartilage. polyP acts as “metabolic fuel” for the synthesis of the extracellular inorganic and organic skeletal and cartilage tissues. Our strategy is to combine and to amplify the beneficial properties of these two polymers, biosilica and polyP, their morphogenetic activity with their structure-forming/guiding activity, by applying hybrid microparticles, consisting of silica and polyP. The proposed project will provide the proof-of-concept of this dual strategy, using silica and the amorphous Mg2+/Ca2+ salt of polyP together with hyaluronic acid, to dissolve firstly existing bone splinters in the synovial fluid (by injection), reducing the painful joint burden in osteoarthritis, and secondly to repair damaged c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Market maturation of a packaging concept for sustainable and resource efficient food packaging' in the context of a Horizon 2020 call.

assistant: **Objectives**

The growing importance of sustainability – interlinking social, economic and environmental considerations – and logistics in the food and drinks supply system mean that packaging has become a key interface of this industry. Additionally, in the increasingly competitive retail landscape, differentiation and product standout is growing more important. This result in fierce competition among retailers and brand owners, leading to a strong focus on packaging cost, environmental sustainability, quality and attractive merchandising displays. However, until now, the increase of functional and environmental performance and appearance has invariably resulted in higher costs creating a business opportunity to a packaging concept that could present sustainable principles and goals whilst addressing cost, performance and market pressures.EcoSave Packaging (ESP) aims to pursue this market opportunity by bringing to market its innovative packaging material and patented assembling process that successfully address all aforementioned needs. The ESP’s assembling method and the ESPack material technology allow several key advantages and value propositions: i) 25-50% lower cost; ii) 30-70% lower environmental impact; iii) better barrier properties; iv) attractive touch-sense; v) high-quality printing options; vi) reduced transportation and storage costs; vii) higher stack pressure; viii) significant less drop damage.  ecoSave project is expected to significantly enhance the profitability of ESP, with expected revenue of €73M and profits of €15M, 5 years after commercialization. Moreover, the successful achievement of ecoSave objectives is expected to assist Europe in achieving objectives to secure resource efficient eco-innovative food processing. This project will therefore entail increa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Control of source-sink relations by carbohydrate regulation of gene expression', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Increasing plant yield potential is still a realistic goal of plant breeding. Plant growth and productivity is determined not only by the photosynthetic activity of the plant, but by the way in which the products of photosynthesis are allocated and utilised during plant growth and development. It has recently been discovered that internal signals arising from primary carbon metabolism directly influence photoassimilate production and utilization through the control of gene expression in source and sink tissues. Such controls therefore regulate carbohydrate allocation and utilization in important sink organs such as tubers, roots, fruits and seeds, and so directly determine plant productivity. The aim of this research is to investigate sensing and signal transduction pathways and their components which mediate carbohydrate regulation of gene expression in source and sink organs, and so control carbohydrate production, utilization and plant yield potential. In so doing we shall subsequently be able to manipulate these sensing and signalling pathways with the aim of beneficially modifying plant productivity. We shall carry out a genetic, molecular and physiological analysis of these signalling systems in the model species Arabidopsis, in order to understand how they work and to provide molecular tools to manipulate them. We have identified several target proteins which are believed to function in carbohydrate sensing and signalling, which shall be the focus of research in Work Area 1. These proteins include sugar transporters, protein kinases and hexokinases. The second work area will involve the analysis of mutants altered in their response to sugar signalling. Three participants have isolated such mutants and we believe that collectively we have ALL the sugar-responsive
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evolution of host specialization and the maintenance of biodiversity in herbivorous insects' in the context of a Sixth Framework call.

assistant: **Objectives**

Understanding the mechanisms generating biodiversity is a central issue in biological sciences. Herbivores are a more bio diverse group than their predators and evidence is growing that this diversity stems from herbivores specializing to their host plants. We aim to study the mechanisms underlying specialization in the weevil Latrines canaries, which occurs on several thistle species (noxious weeds) in the Mediterranean basin. The host range of this insect varies among populations, facilitating the identification of such mechanisms. Previous studies have pointed at the possible role of host phonology, competitors and predators and of trade-offs in adaptations to different hosts, but these hypotheses require testing. We propose to carry out these tests by performing manipulative experiments in the field and in the laboratory, using molecular tools available at the University of Montpellier. Our results will be used to parameterise a model on the evolution of specialization. It is expected that the research project described here helps identifying the mechanisms driving specialization and speciation in herbivorous insects. This insight is instrumental in managing biodiversity and in combating weeds in agriculture, both of which are important issues in EU policy. The applicant will extend her knowledge of Population Biology to Population Genetics, thereby increasing her level of expertise as a professional researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strengthening the European Partnership community', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

ERA-LEARN is the reference point for European Partnerships. It provides evidence and support for their preparation, implementation and evaluation. It is a trusted support platform and service provider for the European Partnership communities, the European Commission, policy makers and other stakeholders at the national/regional level. It supports the Strategic Coordinating Process (SCP) for Partnerships to exploit their potential as an instrument and a policy approach to effectively address major societal challenges. The project activities of ERA-LEARN are geared to serve the specific needs of 1) the European Commission (including executive agencies) 2) EU Member States, Associated Countries, policy makers, and the Partnership Knowledge Hub (PKH), 3) the European Partnership community (governing and managing bodies), and 4) researchers. Collectively, the project aims to increase the effectiveness of the design and implementation of the European Partnerships. ERA-LEARN implements a responsive communication and outreach strategy with various tools and channels for communicating with the broadened Partnership community and the dissemination of results including a strategic and frequent use of social media.The ERA-LEARN consortium will exploit the experience of the previous phases of ERA-LEARN and build on achievements and lessons learned. In particular, the next phase of ERA-LEARN is designed in response to needs of the European Partnership community. ERA-LEARN will engage with the stakeholders and focus on providing support to the Strategic Coordinating Process for the period 2023 to 2027.


**Keywords:** European Partnerships, support to the Strategic Coordinating Process, support to the Partnership Knowledge Hub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Communication middleware for monitoring financial CI - International Cooperation aspects' in the context of a Seventh Framework call.

assistant: **Objectives**

COMIFIN-ICA is a proposal for a collaboration research project among ongoing EU (CoMiFin project, contract ID 225407) and US R&D projects focused on the protection of financialcritical infrastructures.The financial bodies as well as businesses and customers worldwide are increasingly relying on financial infrastructures for their financial activities.At the same time, recent financial market stabilization actions have highlighted the opportunity and convenience of collaboration among the different actors of the global financial system. In order to address some threats and vulnerabilities that may affect financial infrastructures, the European Commission has funded in 2008 a research project named CoMiFin that aims to develop a comprehensive approach to enable the protection of the financial infrastructure through the collaboration of different financial actors and providers of critical services., In the United States, the National Infrastructure Simulation and Analysis Center (NISAC/Sandia) has an on-going project, namely Global Finance as a Complex Adaptive System", that aims to develop models of interactions among banks, foreign exchange markets and other financial institutions.Both projects represent the leading edges in the research about financial infrastructures modelling, management and protection in European Union and United States.The cooperation between those two projects aims at establishing a collaboration in order to reinforce convergent results and leverage on complementary activities.CoMiFin project will disseminate its knowledge on cooperative financial systems in US, and will benefit of NISAC/Sandia knowledge about critical infrastructure modeling. NISAC/Sandia project will obtain advantages from the cooperation with CoMiFin because they can validate th