RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Data science tool for Epidemic FOrecastinG' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Several organisations active in the health care market make decisions based on an estimation of the number of individuals infected with an infectious disease. These organisations benefit from a timely and trust-worthy prediction of the number of infected individuals. To date, infectious disease predictions tools are inadequate because they typically include limited and domain-specific data and because the translation to impact for specific stakeholders in the healthcare market is lacking. DEFOG proposes a data science solution as we will integrate classical surveillance data, pharmacy sales data, out-of-hours general practitioners data and social contact data in a novel real-time forecasting tool that will yield better and more rapid warning signals of the number of infected cases. DEFOG will produce software and know-how under intellectual property of the principal investigator which will be exploited through licence agreements with and consultancy services for various stakeholders. DEFOG will build on recent advances in mathematical modelling for infectious diseases as part of the original ERC-TransMID project. The team offers a vast amount of expertise in mathematical and infectious disease modelling, computational processing, business development and has an extensive collaborative network with research centres, regulatory agencies and companies, of which 4 entities already expressed interest in exploring the use and/or sharing data for of the proposed innovative real-time disease forecasting tool.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Advanced grinding process for near net shape forming tools' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Wear resistant tools for near net shape forming processes are used in the capital and investive goods industry. Examples can be given from the internal profiling by calibrating of tubes or the punching of vessels and cans. The tools used in this field have to cover high wear resistance and form/profile accuracy. Due to the difficult forming operation sequences in the near net shape manufacturing processes the tool geometries are mainly based on free-form or complex regular surfaces (rotational symetric). The materials used for tool manufacturing are in general hard alloy metals (carbides) to serve the manufacturing demands. The objective of this project is to reduce the cycle time for grinding of near net shape forming tools. This will be achieved by use of an advanced CNC high-speed grinding process with specialised diamond wheels. The grinding wheeis will be developed and designed according to the new grinding process requirements. A small series of new wheels will be manufactured for an experimental use under practical industrial conditions. A suitable tool dressing operation will be investigated and optimized for industrial application. Furthermore, an oil-based cooling lubricant will be optimized due to minimum of tool wear, surface integrity and quality as well as environmental and health aspects. An experimental environment based on an external high speed grinding machine tool will be established. The machine tool will be equipped with specified sensors for on-line and in-situ monitoring and surveillance of the process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'XReverb: efficient generation and perceptual evaluation of reverberant spatial audio for Extended Reality'.

assistant: **Innovation**

Extended Reality (XR) refers to the technology which creates a 3D immersive environment where a user can perceive and interact with virtual objects by means of a head mounted display. Even though XR is still an active research area, its European market has already reached an estimated worth of €34 million, employing up to 480,000 people. It is expected that a mature XR infrastructure will raise the standards for remote working by enabling functional virtual workspaces, which could stimulate the European economy by offering equal opportunities to workers regardless of geography, and reduce greenhouse gas emissions due to less commuting, which is in line with European goals. A key part of XR is spatial audio, or sound signals which the user perceives as if they come from specific locations in a 3D space. Realistic spatial audio can be computationally expensive, particularly when simulating reverberation, i.e. the interaction of a sound source and the environment. This project investigates how humans perceive spatial reverberation to build more efficient rendering methods which enable high-quality spatial audio on XR. To that end, a novel reverberation encoding technique is proposed, based on a variable order Ambisonics framework, and a model for sound localisation in reverberation will be developed, which is expected to be a significant advancement in the field of auditory perception. The project will take place at a leading multidisciplinary group specialised on real-time spatial audio processing and who can offer excellent international collaboration opportunities. The researcher will bring skills on evaluation of spatial reverberation and inter-sectoral experience from having worked at a world leading research group within the industry, which will facilitate the transf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Snow generation with reduced energy consumption and noise emission, more consistent quality and extended operating temperature ranges' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Mountainous regions are often strongly dependent on tourism, particularly on winter tourism. Technical snow is of vital importance in operating ski resorts that are fighting climate change. Operating costs and environmental aspects considerably gain importance and threaten feasibility of snowmaking.This proposal presents a multi-barrier approach to establish a scientific basis in technical snowmaking, which was prior dominated by incremental experimental developments. Bringing a scientific understanding to the process development we anticipate major improvements, especially in fluid dynamics and noise-control.Current snowmaking technology is already sophisticated, but still yields a major potential for improvement. High energy demands and therefore operating costs hinder the widespread use of the technology, as well as the high noise emissions that are restricted by law.The new snowmaking system will offer an improved performance allowing production of quality snow with reduced energy consumption at higher temperatures and with low noise emission. This will enable the widespread and financially viable use of snowmaking technology in ski resorts. Operators profit from low operational costs and an earlier season start. The lowered noise emission enables use near residences or wildlife sanctuaries.Tourism industry is major branch in Europe and together with all its linked businesses accounts for 10% of Europe’s GDP and 12% of the total employments. It annually generates €266 billion.The tourism market is steadily growing at about 4%, the high demand on winter tourism is lasting and climate change is threatening. This demands increased use of snowmaking equipment.In developing the new snowmaking equipment we will generate improved technologies in the area of fluid dynamics,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ongoing chromosomal instability in cancer: real-time imaging and single cell genetics of missegregating chromosomes.' under Horizon 2020.

assistant: **Concept**

Genomes from tumor cells are often grossly derailed in DNA content, with chromosomes gained, lost, fused or otherwise rearranged. Presumably, many of these aberrations stem from mistakes during cell division, during which the DNA is normally divided equally to both daughter cells. Cell division is often studied microscopically in 2D cell culture, while DNA sequences from cancer genomes are often re-constructed from tumor patient material. As a consequence, there is still a poor understanding regarding the direct genetic consequences of mitotic errors and as such, genomic instability. Patient-derived tumor organoids, in combination with cutting-edge technology that combines direct microscopic observation of mitotic events, with single-cell whole genome sequencing (scWGS), provide a unique opportunity to tackle these fundamental questions.To understand the occurrence and maintenance of genomic instability, I will study organoids derived from esophageal adenocarcinoma (EAC) patients. While observed in many cancers, EAC genomes in particular show genomic catastrophes and are thought to drive tumorigenic transformation. Cells will be filmed in real-time to detect mitotic errors. Daughter cells from erroneous divisions will be photoconverted, allowing single cell tracking and isolation for prospective genetic analysis. scWGS will detect imbalances in chromosome number and/or structural rearrangements between the paired daughter cells. Genetic aberrations can be directly linked to the observed mitotic error and cell fate across multiple divisions to understand its role in tumorigenesis. To couple molecular mechanisms to genetic footprints, fluorescent markers will be implemented to interrogate the type of DNA damage missegregated chromosomes receive, how this affects the subse
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Theoretical and computational study of polymers - fluorescent proteins mixtures for applications in bio-LEDs' (BIOS).

assistant: **Innovation**

In the field of lighting, a new technology has recently appeared: the bio-LED, which makes use of derivatives of the green Fluorescent Protein (FP) as downcoverting materials. This provides a cheap, green and easy to procure replacement for the currently used rare-earths-based downconverting filters, whose sustainability is hindered by the associated costs and their ecological impact. Despite the encouraging results obtained so far, the bio-LED needs improvements in terms of stability and performances in order to become competitive in the market. BIOS (BIO-led through Simulations)  aims at addressing these issues by studying the fundamental structural and electronic properties of the FP-based filter at realistic, working conditions (i.e. high temperature) using a theoretical and computational approach. This will allow us to characterise the interactions that stabilise the FP-polymer matrix mixture, thus providing guidelines for the chemical design of components of the downconverting filters to improve thermal stability. Hybrid  approaches that makes use of molecular dynamics, molecular mechanics, quantum mechanics and analytical models will be employed to first characterise the interactions that stabilise FPs in non-physiological conditions while allowing them to maintain their optical activity, and then to study in detail the deactivation paths of the FPs, with a particular focus on thermal dissipation procceses, which currently constitute the main obstacle to the market competitiveness of the bio-LED technology. Through BIOS we will therefore obtain insight in the strategies to adopt to improve the performances of the final device.


**Keywords:** Biomaterials, biophysics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mid-blastula transition in mammalian embryos' (2021-2027).

assistant: **Innovation**

Early animal embryos undergo a profound reprogramming of cell behaviour at the blastula stage in a major developmental transition known as the mid-blastula transition (MBT). Earlier studies demonstrated that MBT is an essential transition for embryonic development across various species, involving simultaneous changes in key cellular activities: activation of zygotic genome transcription (ZGA), cell cycle elongation, loss of division synchrony, and onset of cell motility. In contrast, little is known for mammalian embryos, which are often viewed as not having an MBT because of their slow initial cell cycle and early ZGA. However, MBT also exhibits a switch in the cell growth mode from reductive cleavage divisions to proliferative growth, and our recent findings suggest that this switch occurs at the blastocyst stage in mouse embryos. This project aims to identify the mammalian MBT, define its fundamental features and investigate the mechanisms that control its timing. Employing light-sheet microscopy to image mouse embryos at high spatiotemporal resolution, automatic cell segmentation and single-cell tracking, I will quantitatively characterise the cell volume dynamics in early embryogenesis. This will allow me to identify the transition from cleavage to proliferative growth and use this time reference to characterise novel MBT features. Specifically, I will focus on 18 hours within the blastocysts stage to test the hypothesis that mammalian MBT entails changes in cell fate, metabolism, spindle assembly and/or cell cycle control. Through temporally controlled perturbations I will determine if there is a causal link between these changes and identify the upstream regulator, the trigger for the mammalian MBT, as well as the mechanism by which the MBT timing is controlled.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Impact of disruptive events on attitudes on science and democracy in seventeenth and eighteenth-century England and Denmark/Sweden' under Horizon Europe.

assistant: **Concept**

How do disruptive events shape the development of ideas on science and democracy? The question is of utmost importance in our world today as we face an increasing frequency of disruptive events, such as pandemics or wars. To gain a long-run understanding of the fundamental factors that link disruptive events to changes in the development of ideas on science and democracy, the IDEAS-SEED (henceforth IDEAS) project will explore natural experiments in history. Specifically, it will study two university pairs in early-modern Europe that were highly similar in institutions and composition of their student body, yet got treated by plague, warfare, and famine at different times each. The first pair is the University of Oxford and Cambridge in England and the second pair is the University of Copenhagen in Denmark and Lund University in Sweden. The study will cover the timespan of 1600-1720, the time of the Scientific Revolution and competing ideas between liberal Parliamentarianism and kingly absolutism. To quantify ideas, the project will match students at these universities to their publication titles. Then, using state-of-the art techniques in natural language processing and AI, the project will classify the topics of students' publications and identify students' ideological stances. To ensure accuracy free from present-day bias, the study will fine-tune an LLM on historical data. The fine-tuned LLM will be publicly shared and will also be an outcome of the IDEAS project.Overall, the IDEAS project will use a set of natural experiments to explore how disruptive events shaped the development of ideas on science and democracy at the time of the Scientific Revolution and the first writings on liberal democracy- thereby studying the origin of the scientific and democratic beliefs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Helicopters Deploy GNSS in Europe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objectives of this project are to demonstrate new helicopter approach procedures for mountain rescue, offshore oilfield operations, helicopter emergency services and air taxi operations, and support these with necessary standards/certification/safety work to accelerate their operational deployment.Helicopter operations are often restricted to visual conditions which hampers their operational effectiveness. They are also in need of increased safety, since they have accident rates many times higher than commercial fixed-wing operations. This project will help both areas in this growing aviation sector.The project also includes small fixed-wing aircraft demonstrations of EGNOS APV approaches. Fixed wing operational deployments are already being managed by Eurocontrol. So the objectives here are to demonstrate fixed-wing benefits in Eastern Europe (not part of any previous work) and to demonstrate an integrated airport surveillance/navigation concept based on EGNOS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Three Dimensional Single Cell Analysis of the Cancer Stem Cell Inducing Epithelial-Mesenchymal Transition Signaling Networks in Breast Cancer by Mass Cytometry' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Tumor metastases, relapse, and resistance to therapy are the main causes of death in cancer patients. Cancer stem cells (CSCs) drive cancer growth, are likely responsible for cancer reoccurrence, and provide the potential to colonize a metastatic site. A cell plasticity process called epithelial-mesenchymal transition (EMT) generates CSCs from epithelial cancer cells and simultaneously equips these cells with motility and invasiveness, features prerequisite for metastasis. Consequently, therapeutic strategies that target EMT and CSC signaling networks are highly attractive. However, the properties of these signaling networks and their dependency on the tumor microenvironment and cancer genotypes are poorly understood. Here we propose to generate quantitative, time-resolved biomarker signatures and network models of EMT stages and CSCs on the single-cell level and to define their dependency on breast cancer tumor microenvironments and genotypes. Using mass cytometry, a technology able to quantify up to 100 proteins and phosphorylation sites simultaneously in a single-cell, the signaling network structure of EMT and CSC state will be gauged by modulation of cancer-related and signaling genes. These data will be used to infer mathematical signaling network descriptions of EMT and the CSC states, and to determine their master regulators and regulatory sub-networks. By extending mass cytometry to spatially resolved measurements, the EMT/CSC network states and their microenvironment will be analyzed in three dimensions in patient samples, and data will be correlated with associated genomic and clinical information. Based on these in vivo data, follow-up experiments in mouse models will be performed to validate the identified network states and cell-to-cell interaction as ther