RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Radical Chemistry with the Hydrogen Atom Through Water Activation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Water activation, which allows the transfer of universally abundant hydrogen into value added compounds, is an important research field in modern science. This task has been realized mainly by using transition-metal-based systems. Herein we will use a conceptually novel mild water activation strategy which proceeds through a photocatalytic phosphine-mediated radical process. The active species in these processes is a metal-free R3P-OH2 radical cation intermediate where both hydrogen atoms are used in the following chemical transformation through sequential heterolytic (H+) and homolytic (H•) cleavage of the two O-H bonds. The R3P-OH radical intermediate provides an ideal platform to mimic the reactivity of a ""free"" hydrogen atom that can be directly transferred to various π-systems to give H-adduct C-radicals, which are eventually reduced by a thiol cocatalyst leading to overall transfer hydrogenation of π-systems, with the two H-atoms of water ending up in the product. The driving force is the strong P-O bond formed in the phosphine oxide byproduct.Hydrogenation of alkenes, arenes and hetero(arenes) will be investigated, also addressing stereoselective reductions using chiral H-donors. Deuteration and tritiation with D2O and T2O as formal reductants will be explored. Experimental studies will be supported by DFT calculations throughout the studies. Polar effects exerted by the H-donors will be studied, which will allow the design of more complex intramolecular and intermolecular reductive cascade reactions comprising C-C bond forming steps. Reactivity of the novel R3P-OH radicals towards various functionalities will be systematically investigated and the reactive functional groups then incorporated into cascade reactions. Atom-economic radical H-transfer isomerizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Understanding matter-antimatter asymmetries in B meson decays to three particles'.

assistant: **Concept**

The search for sources of CP violation beyond the Standard Model is a high priority in contemporary particle physics. The violation of the CP symmetry is one of the necessary conditions to generate an asymmetry between matter and antimatter, as is observed in the Universe. The LHCb experiment has observed very large CP asymmetries in decays of B mesons to final states containing three charged particles. It is not yet clear whether these effects can be explained within the context of the Standard Model, or whether new dynamics are required. This proposal aims to address this challenge by bringing together the relevant experience and expertise of the researcher and the host institute. The decays of interest will be studied using the Dalitz plot analysis technique, which will allow to establish the dynamics causing the CP violation. The project requires the development and use of several novel approaches to the description of the decay amplitude, and will lead to significance advances in knowledge.


**Keywords:** Beyond the Standard Model, CP violation, Dalitz plot analysis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Laboratory and field methods for determination of bromate in drinking water' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

A large part of distributed waters for human consumption must be efficiently and frequently controlled A 10 ug 1{-1}, regulatory standard for bromate in drinking water as proposed in the new Directive for water intended for human consumption, requires an analytical method with a detection level of at least 2.5 ug 1{-1} (25% of the parametric value). Few water analysis laboratories with statutory function in Europe have demonstrated an ability to determine bromate in drinking water at the ug 1{-1} level.Research, therefore, is urgently needed to meet the following objectives:1. To improve the current laboratory-based method, ion chromatography with conductimetric detection for determination of bromate in raw and potable waters in compliance with the proposed new European Directive of 10 ug 1{-1} to make the method more robust user friendly and less subject to specific interferences and to insure determination capability at the ug 1{-1} level.2. To develop alternative laboratory based methods for determination of bromate in raw and potable waters as per objective 1, and to confirm bromate presence in raw waters.3. To develop novel field based methods for determination of bromate in raw an potable waters.These robust and low cost methods would be suitable for routine monitoring at a waterworks and should be applicable to on-line monitoring.4. To clearly specify the advantages and disadvantages of each method and particularly with respect to potential significant interferences.5. To produce new information concerning the stability of bromate in various types of water (at ug 1{-1} level).6. To validate some of the developed methods and to organise interlaboratory tests involving 8 to 15 laboratories (for the ion chromatography/conductimetry method and one selected field meth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A digital edition of Greek and Roman Sculptors’ signatures (323 BCE-138 CE)' under Horizon Europe.

assistant: **Concept**

SculpSi aims at reconstructing the lives and the works of Greek and Roman sculptors between the Hellenistic period and the reign of Hadrian (323 BCE-138 CE) in the areas corresponding to Roman Italy and the provinces of Achaia and Asia. SculpSi focusses on sculptors’ signatures, taking them as a source of information and a starting point for reconstructing their professional careers: signatures open up many research paths that have yet remained unexploited: their wording, their position on statues or bases, palaeographic dating, language and dialect, etc. They can also help us to reconstruct the work of individual sculptors, attribute them specific artworks and track their mobilities in the Mediterranean. SculpSi will be the first systematic study on sculptors’ signatures between 323 CE and 138 CE: the analysis will be carried out on a corpus of ca. 550 signatures, and will be based on bibliographic data and, whenever relevant, autoptic study; such data will be used to feed Polycles, a prosopographic database already created by the LIMC team at my host institution, but still awaiting launching. The project breaks down disciplinary barriers by combining art history, epigraphy, archaeology, and digital humanities and posing theoretical questions (e.g. role of the artist within society, the idea of authorship) which go well beyond Classical studies. The database -only one of the research products of Sculpsi- will constitute a perennial gate for scholars and students of several disciplines, giving access to data scattered in different parts of Europe and beyond and to the first English and French translations of many inscriptions. Besides being trained in digital humanities, the researcher will develop a unique expertise in Epigraphy and ancient Art History, filling a gap b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Engineering Scalable Algorithms for the Basic Toolbox ScAlBox' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

ScAlBox aims at basic algorithmic tools that can be used in a wide spectrum of applications and that scale orders of magnitude better than the state of the art with respect to input size or number of processors.In the last decades, we witness the transition into the information age with profound effects on science, technology, and our daily life. This transition is driven by a growing spectrum of computer applications that process larger and larger data sets using increasingly complex algorithms. However, the scalability challenge has emerged as a major road block to this progress:An explosion of the amount of data to be processed (big data) coincides with stagnating performance of a single processor core. This widening performance gap can only be closed using many parallel processors. However, parallel algorithms have long been neglected by algorithm theory while heuristic software development optimizes for existing machines and inputs but fails to give predictable scalability for future, larger data sets and more processors.We want to overcome this roadblock by developing scalable solutions for the basic toolbox of algorithms and data structures that are needed in many applications (e.g., sorting, searching, queues, basic graph algorithms, collective communication, and load balancing). My goal is to provide algorithms and software libraries that scale to millions of processors and give hard performance guarantees for arbitrary inputs. This is challenging due to large gaps between theory and practice and because such algorithms have to integrate scalable fault tolerance and dynamic load balancing to an unprecedented extent. I am the right person to achieve this due to my extensive experience in parallel algorithms for irregular problems and my leading role in algorithm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Revealing hidden volcanic triggers for global environmental change events in Earth’s geological past using mercury (Hg)'.

assistant: **Objectives**

Rapid global change events such as mass extinctions punctuate Earth’s geological history. These have driven life’s evolution, shaping the world today. However, the exact processes that trigger or modulate them remain enigmatic. Episodes of large-scale volcanism, namely large igneous provinces (LIPs), are a prime contender. A major obstacle to unravelling the role of LIPs in rapid global change has been lack of a direct/unique proxy for volcanism in the sediments that record events. Without one, determining LIP occurrence and exact temporal relations is challenging, especially where the rock record of LIPs is incomplete. Recent studies have revealed the huge promise of mercury (Hg) as a marker of large-scale volcanism. However, while Hg-record acquisition is gaining pace, we still lack the vital process understanding of the proxy needed to realize its full potential. V-ECHO will test the overarching hypothesis: widespread mercury ‘spikes’ in the geological record are definitive evidence of LIP volcanism even in the absence of coeval lavas.V-ECHO will take an integrated and interdisciplinary approach to develop a process understanding of LIP perturbations to the global Hg cycle and how these translate into sedimentary records. It will address key questions on Hg sources (emission from magmas or thermal metamorphism of intruded rocks) and sinks (deposition pathways and sedimentary preservation). It will combine new measurements with novel experimental techniques and explore key differences in the global Hg cycle deep in Earth’s past. V-ECHO will test whether we can ‘sniff out’ the sedimentary echoes of lost LIPs, especially in the Palaeozoic and Neoproterozoic where the LIP record becomes ever sparser. It will explore proposed volcanic triggers for major Earth change event
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Financial support for young researchers to participate in the large European Conference EPDIC-7""' to be submitted under Fifth Framework.

assistant: **Abstract**

EPDIC is the only European Conference exclusively devoted to powder diffraction. The main objectives of the conference are to show the state-of-the-art of the technique (which are published later in the international journal Materials Science Forum) and to present the major instrumental advances. Since most large laboratories and industries have PD equipment, any advance in the technique has a direct impact in research and in production. The principal attractiveness of PD is that it provides information on both the structure and the microstructure of the materials. The advent of the PC's and the availability of large European facilities like ERSF or ILL have increased the possibilities of PD spectabularly. Actual relevant topics are the methodology for crystal structure determination from PD data and their combination with data coming from different sources. Improvement of this methodology is necessary for processing patterns collected in situ (e.g. reaction cells) or also under non-ambient conditions (high pressures). Other important topics for their technological significance are the mircrostructure modelling, the depth sensitive texture analysis and the use of X-ray mirrors to thin film analysis and multilayers reflectometry studies.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00012-1.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'NOA, a disruptive portable device to monitor asthma', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In Europe, about 30 million children and adults under 45 years old have asthma. There is no cure for asthma, it is a chronic disease. Asthma can have a very negative impact on the quality of life of those people who suffer from it. However, it can be diagnosed and effectively controlled at an early stage. The total cost of the disease for the European population aged between 15 and 64 was EUR 19.3 billion per year.We have developed the NOA device, that monitors asthma in a simple, painless, non-invasive and precise way, with accurate and immediate results. The NOA is useful for both preventive and post-treatment monitoring.The basis of the NOA device is its ability to measure the Fraction of Exhaled Nitric Oxide (FeNO) of human breath, which is a marker that indicates the existence and extent of inflammation to the upper airways caused by asthma.The NOA is the only portable device able of monitoring asthma with high accuracy, and is easy to use and very fast (5 seconds) because of an innovative patent-protected technological development that combines electronics and pneumatics, sensors and mathematical algorithms. Our solution is based on studies carried out with high scientific rigor, which allows us to guarantee the validity of the NOA. The NOA device has been successfully tested by more than 100 people and 35 doctors.Our client’s segments are hospitals with departments of allergology and/or pneumology and pharmacies. The NOA has important advantages in regard to convenience, speed of the test, price and business model, making it feasible for pharmacies to offer a service that has, up to now, not been on offer.The general objective of the Innovation Project is to bring the NOA device to the European market. Phase 1 of SME Instrument represents an opportunity to get a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The origin of living wild equids (zebras and asses): Fossils and molecules fill the gap in the evolutionary history of the genus Equus.' (STRIPES), addressing dissemination and exploitation.

assistant: **Impact**

The evolutionary history of the genus Equus is a paradigmatic case of adaptation to different environments through time. Modern equids may be divided in two large groups based on genomic and morphologic evidence: the caballine horses (Przewalskis and domesticated horses) and the stenonian wild equids (zebras and asses). Although molecular studies have clarified the evolutionary history of the caballine horses, the origin and evolution of the wild zebras and asses remains enigmatic, despite their well deciphered genomes. STRIPES aims to resolve the phylogeny of the genus Equus, with emphasis on extant zebras as well as African and Asian asses. To do so, I plan to study the fossil horses collections housed at the ICP (Sabadell, Spain), of the the MNHN (Paris, France) and of the NHMUK (London, England). These institutions have important collections from key sites in Eurasia and Africa, with ages matching with the estimated divergence time interval between zebras and asses at ca. 1.8 Ma. I will use 2D and 3D geometric morphometric approaches to more accurately characterize the anatomy of the fossil and living Equus species, and I will further integrate morphological information with genomic (paleoproteomic and molecular) data to perform the first Bayesian total evidence (tip dating) phylogenetic analysis of the genus Equus, which will enable to refine the branching topology and estimated divergence dates of its main lineages. The combination of paleontological and neontologial data, both morphological and molecular, represents a transverse approach of this study between Paleontology, Zoology, and Molecular Biology. The results of this project will yield the most complete phylogeny of the genus Equus thus far, pushing forward the current state-of-the-art and clarifying the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding and preventing the impact of endocrine disruptors on the hypothalamus-pituitary axis in sensitive populations' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Exposure to multiple endocrine disrupting chemicals (EDC) is an environmental insult that interferes with the development and function of the endocrine system, governed by the hypothalamus-pituitary (HP) axis. This interaction is specially concerning in developmental stages of life, such as the perinatal period and puberty. Despite the current body of knowledge on EDC actions on the endocrine system, a comprehensive, holistic understanding of the impact on the HP axis is still lacking. HYPIEND aims to understand the effects of EDC co-exposure in the function and epigenetic programming of the HP axis to delineate interventional strategies for minimizing exposure and consequences on the neuroendocrine system during the perinatal and pre-pubertal stages. To do that, a computational toxicology methodological framework will be built leveraging public data and state of the art data analysis techniques to define EDC co-exposure patterns in target population. The resulting patterns will be evaluated in a sequential tiered approach consisting in cell-based screenings, Danio rerio models of HP axes, in vitro, in silico and in vivo models of placenta and blood brain barrier diffusion and new models of organoids-based organ-on-chip recapitulating the HP axis. EDC effects on epigenetic programming will be evaluated in preclinical models of perinatal and early childhood. Whole genome DNA methylation patterns in the different models will be explored as a source of non-invasive biomarkers of HP axis disruption by EDC. The knowledge generated in preclinical models will be applied in two multi-centre-controlled intervention studies intended to minimize exposure to EDC in children in the perinatal and pre-puberty stages. HYPIEND outcomes will be novel approach methodologies based in in vi