RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Dynamics of chromatin structure in model and pathogenic yeasts'.

assistant: **Objectives**

In eukaryotic organisms, essential processes such as RNA transcription, DNA replication and repair are dependent on chromatin structure. Chromatin modifying enzymes are critical for the dynamic regulation of chromatin structure during the cell cycle and the maintenance of proper cell function. The proposal is focused on the Saccharomyces cerevisiae Esa1 protein, a member of the conserved MYST family of histone acetyltransferases. Indeed, Esa1p is involved in very diverse processes such as transcriptional silencing and activation, and have critical roles in DNA damage repair, cell cycle control, and chromosomal and sub-nucleolar architecture. Yet, much remains to be learned about Esa1p genomic targets and interactions.The aim of this project is to characterize the functional diversity of the MYST HAT Esa1p in DNA-dependent processes. Esa1p is known to regulate activation of transcription through chromatin acteylation within a multimeric complex called NuA4. We will ask whether Esa1p promotes silencing through this complex or another one, yet unidentified. At last, newly defined HAT activities that suppress esa1 mutants will be characterized and their function in DNA damage/repair explored.The new skills and knowledge acquired during this training in a third country organisation will be transferred and applied to the pathogenic yeast Candida albicans. Indeed, knowledge on chromatin structure function in this species is limited. Most interestingly, various aspects of C. albicans biology are likely to be the subject of epigenetic regulation involving changes in chromatin structure. Thus, we will initiate the functional characterization of the ESA1 homologue in the biology and pathogenesis of C. albicans. This project will allow the applicant to gain a highly qualified train
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From Essence to Cinnamon: Making our Proprietary CMS Open Source for Customizable Web- Platforms' (Cinnamon).

assistant: **Concept**

75% of all websites are open source, even the European Commission platform mainly relies on Drupal today. Whilst most of the open source CMS platforms have many users, they each have their weaknesses. This is why many companies still rely on custom software development or simply reach for a template or customize a theme. Cinnamon Open Source CMS: Since 2005, we are using our Apogee Essence proprietary CMS that is is easy to use, safe and allows changing the core code with limited programming skills. We now want to take the next step and make it open source and call it Cinnamon Web Development Framework. Cinnamon is a powerful CMS and Framework that allows for fast, flexible and problem-free development, management and maintenance of any website, e-shop or portal. Cinnamon allows creating dynamic web applications and websites that are not only well structured and attractive, but that are also visible and popular within the web. A website has become a business card and proof of existence for companies. Still, ha lf of all businesses do not have a corporate website. As a consequence, there is still much room for growth, and Cinnamon can facilitate this task. This gives us access to the European web content management market size is predicted to account for 20% of the overall market share by 2022, which is around €1.9 billion.We will follow a freemium model where developers and designers can use the platform for free and then sell their templates and plugins, etc. within Cinnamon to other users. Both of our general partners Nektarios Baziotis (Managing Director) and Markos Giannopoulos (CTO) together with a team of senior developers and UI Experts are fully committed to making Cinnamon a success as we see this as the next logical step for our business as it offers major gro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Share it! Content sharing in home-to-home networks' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The Share it! project aims to develop an end-to-end system that enables easy access to and transfer of personal content between local storage devices using home-to-home (h2h) networks and that enables innovative servicest hrough a seamless combination of on-line, broadcast, and stored content. To achieve this objective, the project will develop technologies that allow secure remote viewing and manipulation of stored content through broadband connection, the convergence of broadcast content and user-produced content and metadata.OBJECTIVESThe main objective of Share it! is to develop an end-to-end system that enables easy access to, and transfer of, personal content between local storage devices using home-to-home networks and that enables innovative services through a seamless combination of on-line, broadcast, and stored content. Another important objective is the contribution and adherence to standards. This enables true interoperability across different content providers, service providers, and equipment manufacturers.DESCRIPTION OF WORKIn the first half year of the project, technology and user requirements will be studied. Based on these requirements an end-to-end system architecture will be developed. For interoperability reasons public interfaces need to be standardized. Existing standards will be used where appropriate and new ones will be defined and standardized in the relevant standardization bodies, such as TV-Anytime Forum and DVB. Subsequently, an interoperable storage system that enables easy access to content and applications in home-to-home networks will be developed. In parallel several application and service concepts based on the integration of broadband to and from the home network with mass local storage will be tested for feasibility. Some applicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Deoxyuridine Triphosphate Nucleotidohydrolase as a drug target against Malaria'.

assistant: **Concept**

There are around 500 million clinical cases of malaria each year and about 1-2 million people die from this debilitating disease. There is an urgent need for the development of new drugs owing to problems with drug resistance. New drugs should have novel mechanisms of action to prevent cross-resistance with existing drugs. We have discovered some novel, drug-like and selective inhibitors of the Plasmodium enzyme, deoxyuridine triphosphate nucleotidohydrolase (dUTPase). The role of the enzyme is to hydrolyse dUTP to dUMP, maintaining a low dUTP:dTTP ratio. The aim of this project is to optimise these early lead molecules to generate preclinical drug candidates. The project will consist of: medicinal chemistry to prepare and optimise lead compounds; ADME-Tox assays to ensure that the compounds have correct 'drug-like' properties; assays to determine the efficacy of the compounds; mode of action studies; crystallography of inhibitors with the enzyme active site to assist in the drug design process.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'All AtlaNtic Cooperation for Ocean Research and innovation' to be submitted under Horizon 2020.

assistant: **Abstract**

The main ambition of AANChOR is to promote the implementation of the South Atlantic Research and Innovation Flagship initiative and the Belém Statement (BS), signed by the EU, Brazil and South Africa in 2017, to upscale research and innovation cooperation within the Atlantic basin, from Antarctica to the Arctic. AANChOR will pursue this ambition by providing the EC and the BS Implementation Committee (to be established by signatories of the Statement) with a framework to identify and contribute to the implementation of concrete long-term collaborative activities, reinforcing international cooperation between Europe and tropical and South Atlantic countries and connecting with the challenges and research needs of the North Atlantic Ocean. AANChOR will be responsible for launching a multi-stakeholder platform to identify collaborative activities, building on national and international ongoing initiatives such as the All Atlantic Ocean Research Alliance and addressing activities aimed at reinforcing capacity building, promoting academia-industry knowledge transfer for an enhanced ocean innovation, developing common standards, enhancing citizen awareness and ocean literacy and converging and aligning R&I infrastructure initiatives. To contribute to the implementation of the identified joint activities, AANChOR will provide seed money for the first development stages of selected joint pilot actions and support the identification of the most appropriate existing funding mechanisms and tools for further development of the selected activities. AANChOR will also define long term measures for the sustainability of the cooperation framework beyond the lifetime of the CSA. Recognising the evolving nature of the BS implementation, flexibility has been incorporated into the structure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'First in Man Novel Anticancer Therapeutic based on Dependence Receptors Concept'.

assistant: **Concept**

It is usually assumed that transmembrane receptors are inactive unless bound by their respective ligand. Against this dogma, the CLB proposed that some receptors may also be active in the absence of ligand and in this case trigger cell death. These receptors were called dependence receptors (DR) as their expression at the cell surface leads the cell to be dependent for its survival on ligand availability. The prototypic DRs are receptors DCC and UNC5H that bind their ligand netrin-1. The FP6 HERMIONE project (2006-2009) aimed to show DRs are negative regulators of tumor progression and to provide a setting in which DRs could be used in therapeutic perspective. The project was successful in these 2 aspects. Of interest, it was shown that in a large fraction of human cancers netrin-1 is autocrinally expressed to block DCC/UNC5H-induced apoptosis and that interference with netrin-1/receptors interaction is associated with tumor growth and metastasis inhibition in animal models of various cancer types. The results of HERMIONE and subsequent R&D performed by the HERMIONE-spin-off company Netris Pharma (NP) allowed the development of a promising anti-cancer drug candidate (anti-netrin mAb). Large pharmaceutical firms declared their interest to acquire this biologic after completion of human safety and possibly efficacy data. The challenge now is to bring rapidly and successfully this product to the patients. This requires maximum effort to develop the anti-netrin mAb production process, to perform preclinical regulatory toxicology and pharmacology, to evaluate the safety and gain some data on the efficacy of this biologic in human. The final objective of the project is a first-in-class first-in-man clinical trial. The HERMIONE-2MAN project will pave the way to an outstanding
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Autonomous Reed Bed Installations' under Seventh Framework.

assistant: **Concept**

Subsurface-flow constructed wetlands have become a very popular cost effective and green technology for treatment of waste water throughout Europe and the rest of the world.  Original predictions over the longevity of constructed wetlands were approximately 50 -100 years (Conley et al 1991).  However, it has become disappointingly apparent that these systems are clogging and have on average a lifetime of less than 10 years (Griffin et al 2008). Currently when a wetland becomes clogged, the whole site has to be refurbished and the reeds regrown, which takes several years and has significant economic consequences for the operators.Our project ARBI aims to develop and trial an Autonomous Reed Bed Installation containing a magnetic resonance probe, can be deployed in several locations within a wetland to give measurements at different depths.  By measuring the relaxation times of MR, sufficient information can be obtained to determine the clog state of the gravel bed of a wetland. This would enable the operators to isolate those areas of the bed where the problem resides and make a partial intervention, without the need to remove and re-plant the whole reed bed. When the system is  developed, we will have potential for application in other water treatment systems based on subsurface flows like: slow rate sand filters, and river bank filtration.The project will have major benefits for those organisations who would like to install reedbeds but  have resisted doing because of concerns over performance and maintenance costs.  These will increase the potential size of the market for reedbed installers and benefit the SMEs in the consortium who currently are operating in a constrained market which has not achieved its true potential.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Dynamical constraints for the predictability of heat waves in current and future climates' (HEATforecast), addressing dissemination and exploitation.

assistant: **Impact**

In summer 2018, a devastating heat wave affected the entire Northern Hemisphere. Climate change projections indicate that the severity and frequency of such heat waves will further increase over the next decades. At the same time, models remain unable to predict heat waves at lead times of a few weeks  a crucial planning timescale. The poor prediction skill at timescales of weeks to months is to a large extent due to an incomplete understanding of the underlying physical drivers of heat waves. In particular, the atmospheric fluid dynamics responsible for heat waves and their prediction are not sufficiently understood and tend to be biased in models. The seasonal cycle further modulates the drivers and predictability of heat waves. Climate change projections disagree on the changes in atmospheric dynamics responsible for heat waves. The proposed research takes an unconventional path to address these open questions by building a process-based hierarchy of prediction systems ranging from a dry dynamical core to a prediction system using full physics. This hierarchy approach is novel for prediction systems. By systematically adding processes to the model, the relative contribution of atmospheric dynamics and surface drivers for heat waves and their predictability can be estimated throughout the seasonal cycle and for the projected changes in heat waves with climate change. While solving a fundamental question in atmospheric fluid dynamics, the proposed research aims to significantly extend the warning horizon and thereby minimize the societal consequences for future heat waves, which are expected to increase in frequency but so far remain unpredictable. This project combines the experience and strengths of the PI in atmospheric dynamics, predictability, and their applicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European network on children's susceptibility and exposure to environmental genotoxicants' (CHILDRENGENONETWORK) under Fifth Framework.

assistant: **Objectives**

Prenatal, newborn and childhood exposures to genotoxicants pose a special risk due to differences between child and adult in susceptibility and exposures. Some information from European studies with maternal/foetal tissues and with children is available but need systematisation and validation for use in risk assessment. This concerted action will focus on essential topics in feasibility studies: Foetal exposures (placental transport), comparisons of child/adult exposures to urban air pollution, comparisons of metabolism, DNA-damage and DNA repair. Collecting, describing, evaluating and comparing available studies within Europe will also compare the geotaxis effects in children versus adults. Special work packages are devoted to risk assessment and ethical considerations. A survey on available bio banks forms basis for follow up studies in 6th framework program. The proposal comprises input from 13 different European countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EEN Innovation Management Services Berlin-Brandenburg' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Berlin Partner für Wirtschaft und Technologie GmbH (BP) and ZukunftsAgentur Brandenburg GmbH (ZAB), the two economic and technology development agencies of Berlin and Brandenburg, both partners in the Berlin-Brandenburg Enterprise Europe Network consortium, are going to offer innovation management consultancy to SMEs with high potential for innovation, internationalization and growth. The new service will allow the agencies to broaden their service portfolio to SMEs and to support existing programmes for research and innovation. While the latter usually concentrate on technologies and other outputs, InnoManage BB will focus on internal management processes and capacities in the SME in order for them to successfully innovate. Target groups of InnoManage BB are a) companies which have successfully applied for funding in the SME instrument of H2020, and b) other SME in Berlin and Brandenburg which show the potential for innovation, internationalization and growth. As both BP and ZAB have been responsible for realizing the innovation strategies of their respective federal states since more than ten years, both agencies are fully familiar with the scope and challenges facing innovation-orientated companies. BP aims to consult 11 SME in 2014, ZAB 7.


**Keywords:** Innovation, management, SME, H2020, Horizon 2020, SME instrument, SME coaching, innovation processes, management enhancement, innovation consultancy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A social normative model of solidarity-based collective action: Mobilising support for indigenous rights through social media' (MobiliseSolidarity) under Horizon Europe.

assistant: **Objectives**

Indigenous rights groups have become increasingly active worldwide. Mobilising support for indigenous rights movements aligns with a key UN Sustainable Development goal, (10) Reduced Inequalities. This fellowship aims to elucidate how support for indigenous rights movements can be mobilised among the public by capitalising on the influences of social norms and the ease at which they are spread through social media platforms. Though social media can be a tool for mobilisation, little is known about the psychological impacts of perceiving messages of solidarity online. In this fellowship, I will expand my expertise on social norms by examining whether and how these normative messages influence advantaged groups engagement in indigenous rights movements, and how these messages impact the indigenous groups themselves. I will employ innovative experimental and longitudinal methods to illuminate how different normative messages facilitate different psychological motivations for solidarity-based collective action. I will draw on my current expertise in attitude networks to examine the issue from a novel perspective, and transfer these skills to my TC Host. I will gain skills in social media analysis and longitudinal data analysis, which are vital for the research programme, and which I will transfer to my EU host. The impact of this research will be enhanced by utilising a multigroup and multicontext approach, comparing findings from advantaged groups and disadvantaged indigenous groups across Chile and Ireland. This fellowship will expand the psychology of social movements by presenting a novel normative approach to solidarity. Findings will assist Mapuche and Mincir rights organisations in Chile and Ireland respectively in understanding how framing of social media campaigns