RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Non-Equilibrium Processes in Galaxy Clusters'.

assistant: **Innovation**

I propose to study the dynamical and nonthermal processes in the intracluster medium (ICM) by combining a phenomenological analysis of observational data, a theoretical study, and dedicated numerical simulations.The proposed research is designed to address the central open questions in the theory of clusters, resolve the present tension between observations and simulations, distinguish between different theoretical models, and prepare for future observations.One main goal of the research is to disentangle the distributions of cosmic-rays, magnetic fields, and turbulence in the ICM, and identify their origins, evolution, and implications.A second goal is to facilitate a self-consistent model for the cool cores observed in the centers of most clusters, by identifying the mechanism that stabilizes the core against cooling, the feedback processes that render it robust, and the role played by active galactic nuclei and global flows.The research is motivated in part by the apparent lag of ICM theory behind the recent observational progress and the present numerical capabilities. In particular, it would utilize the recent observations of cold fronts, spiral patterns, and radio minihalos, that appear to exist in most cores.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nemael' under Fifth Framework.

assistant: **Concept**

The 5th RTD Framework Programme of the EU is presented under the heading: Creating a User-Friendly Information Society. It has as its main objective the realisation of benefits of the information society for Europe both by accelerating its emergence and by ensuring that the needs of individuals and enterprises are met"" New media and everyday life in Europe Conference addresses this agenda directly. The Conference will investigate the social dynamics of the information Society from the point of view of the user, the consumer and the citizen. It will advance understanding of the relationship between technology (use), market (consumption) and the polity (Citizenship) by examining the dynamics of the new ways of living and working promised by the transition to the Information Society.The field itself is a new one in Europe. Research on technology grounded in interdisciplinary social scientific approaches to the new media is just beginning to have significant effects on the ways in which innovation is understood, and managed. It is possible to suggest that European research leads the world in this area. However, expertise is limited to a small number of Research centres, most of which are spread over different EU Programs, Actions or network.Our first objective is to create a forum for the high-level encounter of leading European academics in the field of new media and society, who are spread in Europe on a myriad of national, international and EU research projects (see sections on European added value for details). Conversely, little funding and opportunity is available to scholars to transcend the physical and intellectual borders of their networks, and create a truly European Res Publica Literarum in the field of Information Society. The main objective of our conference
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Maximizing the integration capacity of the European Union: Lessons and prospects for enlargement and beyond' (MAXCAP), addressing dissemination and exploitation.

assistant: **Impact**

The ‘big bang enlargement’ of the European Union (EU) has nurtured vivid debates among both academics and practitioners about the consequences of ‘an ever larger Union’ for the EU’s integration capacity. The research project MAXCAP will start with a critical analysis of the effects of the 2004- 2007 enlargement on stability, democracy and prosperity of candidate countries, on the one hand, and the EU’s institutions, on the other. We will then investigate how the EU can maximize its integration capacity for current and future enlargements. Adopting an inter-disciplinary and mixed methods approach that combines desk research, in-depth interviews and Q-methodology, MAXCAP willa) explain the effects of the EU’s integration modes and strategies on democracy and socio-economic development in the new members, candidates and neighbourhood countries;b) inquire into the relationship between the widening and deepening of the EU by establishing conditions for effective decision-making and implementation in an enlarged EU;c) identify the social limits to the EU’s integration capacity related to citizens’ perceptions of the last and future enlargements;d) study the EU’s current and past negotiation strategies in the context of enlargement and investigate to what extent they need to be adjusted to changing conditions in the EU and the candidate countries;e) examine how the EU employs different modes of integrating countries with highly diverse economic powers, democratic qualities of governance, and institutional capacities andf) assess whether alternative models, such as the European Neighbourhood Policy, can be successful in bringing countries closer to the EU.MAXCAP which features a nine-partner consortium of academic, policy, dissemination and management excellence will create new
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DNA Damage and Repair and its Impact on Healthy Ageing' (Dam2Age), addressing dissemination and exploitation.

assistant: **Impact**

We pioneered an initially highly controversial connection between DNA damage and (accelerated) aging. In the previous ERC grant ‘DamAge’ we reached the stage that (segmental) aging in DNA repair-deficient mice can be largely controlled. The severity of the repair defect determines the rate of segmental aging; the repair pathways affected influence which organs age fast; conditional repair mutants allow targeting accelerated aging to any organ. Importantly, we found that dietary restriction (DR), the only universal intervention known to delay aging, extends remaining life- and healthspan in progeroid Ercc1Δ/- mutants by 200% (see Vermeij et al., Nature 2016 and fig.2). Also Xpg-/- progeroid repair mice strongly benefit from DR, generalizing this finding. The prominent Alzheimer- and Parkinson-like neurodegeneration is even retarded up to 30-fold(!) disclosing powerful untapped reserves unleashed by 30% less food, with enormous clinical potential. Also we discovered that in accelerated and normal aging gene expression declines due to accumulating stochastic transcription-blocking lesions and that DR counteracts genomic dysfunction. In Dam2Age we will focus on the cross-talk between DNA damage, aging and DR with emphasis on the relevance for normal aging, elucidate underlying mechanisms and use our unique -for DR research superior- mouse models and a variety of novel assays to search for effective nutritional-pharmacological DR mimetics. This serves as a stepping stone towards potent universal therapy for a range of repair-deficient progeroid syndromes and prevention of many aging-related diseases, most urgently dementia’s, to promote sustained health.


**Keywords:** Premature aging, nutritional intervention, dietary restriction, progeroid syndromes, mouse, models, DNA re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'UK Presidency Conference. The European Charter and Code for Researchers: Turning Policy into Practice' (2002-2006).

assistant: **Innovation**

In response to the ERA debate started in 2000 and consolidated politically by the Lisbon agenda, whose overall strategic objective is to make 'Europe the most dynamic and competitive knowledge economy in the world by 2010', the European Commission has adopted new instruments aimed at contributing to the development of a European labour market for researchers, namely the European Charter for Researchers and a Code of Conduct for the Recruitment of Researchers. These provide a framework of general principles for the roles, requirements and entitlements of researchers, funders and employers.This UK Presidency conference is designed to explore the benefits of adopting these principles and identify the practicalities of application. The conference will use a mix of strategic plenary presentations, practical workshop sessions and panel discussions to explore the issues and develop practical solutions. The keynote speakers and workshop leaders will be drawn from a range of experiences across sectors and Member States. In order for the principles of the Charter and Code to be adopted it is important to facilitate change within employing organisations, which need to be convinced of the benefits of implementation. Thus the participants will include people that are empowered to ensure a real change.Participants will include:- HR and Personnel Directors of both academic and non-academic employers;- University Deans and R&D Directors;- National and European representative bodies concerned with the interests of researchers;- National and European bodies representing researchers; and- Professional associations and institutions including government representatives and awarding bodies concerned with postgraduate education and employment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Upgrade Speed To Accelerate Revolutionary Telecoms', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The replacement of aging copper wire telephone legacy, internet infrastructures requires substantial investment and civil engineering works, such as the digging-up of roads to lay down high-speed broadband, account for up to 80% of the cost of deploying high-speed networks.  Telecoms companies are rolling out fibre networks within EU member countries, across Europe, and in countries in the rest of the world. However, those companies are meeting their implementation targets by installing fibre from the area network to the street cabinet (otherwise known as the “Final Mile”) where it is most economic to do so leaving some 10 to 15% hard to reach broadband subscribers with a substandard service.  Furthermore, whilst the target of 100Mbps was the target for 2020 set in 2012, technology has moved on and the new standard being set by countries such as South Korea with advanced digital networks is up to 10Gbps. Although copper wire internet infrastructures are slow they are ubiquitous, based on telephone communication and reaching into almost every household and business.  F2F’s solution is a cable extraction technology to enable the utilization of the copper wire infrastructure and with very limited expensive excavation replace the copper inner core of the pre-existing cable with fibre optic cable using the original cable sheath as a duct.  Our technology is focused on extraction and replacement of the copper core cable both from the broadband backbone to the area network and from the area network to the street connection point. It works by compressing the copper inner core within the sheath of a buried or ducted cable using a lubricating fluid injected at pressure between the cable sheath and wrapping around the copper inner core. Once the inner core is fully compressed, it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The politeness system and the emergence of a Sprachbund'.

assistant: **Innovation**

This research aims to fill the gap about the 18th and 19th- Spanish and Portuguese spoken in the Iberian Peninsula, by analysing the emergence and development of their own pragmatic system in forms of address.  Both languages underwent deep changes from 1700’s onwards, but these have been hardly researched although some of them affected both sides of the Atlantic. This project attempts to shed light on the arising of a politeness pronouns system that is only attested in the south-western part of the Peninsula and which does not follow the standard or any other system elsewhere in Spain and Portugal. By collecting private correspondence and juridical documents that show real language use, this investigation intends to find why this phenomenon emerged in the south-west, what type of speaker prompted or disfavoured it, what evolution it underwent until establishing itself and what linguistic behaviour it has been characterised by. Likewise, the study of this feature may also underpin the theory about a Sprachbund formed in the south-western Iberian Peninsula between Spanish and Portuguese and how its relation with America prompted common linguistic developments in both the European and American varieties. This study represents pioneering research, since more and more authors are drawing attention to the importance of the 18th and 19th centuries as turning points in the evolution of Spanish and Portuguese, and how these centuries can help understand the current state of both languages and the differences witnessed not only on both sides of the Atlantic, but also within the Iberian Peninsula.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A Novel Detection protocols for REliable prostate cancer Assays' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The technology validation was successfully completed indicating a great commercial potential, and the innovative and inventive aspects of the assay platform are now covered by the filed priority European Patent Office (EPO) patent applications. Validated glycoprofiling of the proteins now uses lectins in a format, fully compatible with clinical PSA assay kits. This PoC grant focuses on 1. Pre-clinical retrospective validation of the early stage biomarker of prostate cancer (PCa) and 2. Commercialisation of the PCa diagnostics kit. Pre-clinical (60 human serum samples) is ongoing and retrospective validation study (450 human serum samples) of the assay will be performed by statistical analysis using a receiver operating characteristic (ROC) curve. The PoC describes all steps, which have been developed so far and all necessary steps, which need to be done for retrospective validation study, product development and commercialisation through our newly incorporated start-up Glycanostics Ltd. (www.glycanostics.com). We will provide PCa diagnostic test resulting in a second opinion to guide the right decision if the biopsy is needed. This will avoid the needless and unreliable biopsies and in the future rival an inaccurate PSA testing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Adaptive Flight Control for Advanced Aircraft Concepts' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Worldwide aviation traffic is predicted to increase manifold, putting challenges on the safety and environmental impact of air transport. Safety as well as “green” aircraft fit in the EU FP 7 Research Vision for Aeronautics. This will require advanced aircraft concepts. Advances in the development of nonlinear and adaptive control theory turn these control algorithms into enabling technologies for these advanced aircraft concepts. Two important examples are fault tolerant and next generation ""green” aircraft. In the former category, a Fault Tolerant Flight System (FTFS) is capable to detect and adapt to changes in the aircraft behaviour. For next generation ""green” aircraft to enforce energy efficiency and environmental compatibility (fuel consumption, emissions and noise), nonconventional strategies are required to control them.Therefore, this project will focus on some key aspects of reconfigurable flight systems for these new concepts. In my PhD, I have already focused on system identification and adaptive control and a few months abroad at DLR in Germany opened up a new perspective on adaptive control. However, flight envelope estimation and flight path prediction, to be considered in this research, are other crucial aspects which need to be included in the global setup of technological solutions for safety. Our approach differs from others since it is physically inspired. This more transparent approach allows interpreting data in each step, and it is assumed that these physical models based upon flight dynamics theory will therefore facilitate certification for future real life applications.After the fundamental developments, research results will be evaluated in the highly sophisticated simulators and flight testbeds at NASA Ames and DLR Oberpfaffenhofen. Since
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Health and mortality in central Europe - trends and determinants' under Fourth Framework.

assistant: **Concept**

Research objectives and content It is now apparent that levels of health in the former socialist countries of central and eastern Europe are substan- tially worse than those in the west. After the collapse of the Soviet bloc around 1990 these countries were faced with rapid and widespread societal and economic changes but little is known about how health has been affected by this process. The proposed study will analyse and compare recent health trends in Poland, Hungary, the Czech Republic, and East Germany accompanying this process of transition using mortality data supplied by the WHO and routine data sets from these countries. Based upon a close inspection of these data, I will systematically analyse recent trends in health status in the chosen countries by comparing age-specific death rates for major conditions. Further analysis will examine the contribution of deaths at different age groups and from different causes to changes in life expectancy at birth by using a series of standard demographic tools. The results will not only inform about general mortality trends in Poland, Hungary, the Czech Republic, and East Germany in the post-socialist era but also about specific health problems facing the different countries. For studying potential underlying causes for observable health trends, additional data from health and life-style surveys from East Germany (National Health Survey) will be analysed, primarily focusing on alcohol consumption with other health risk factors also being taken into account. Training content (objective, benefit and expected impact) The proposed study will enable me to acquire competence in methods and techniques required for evaluating and analysing health data on the international level and will lead to a doctorate degree (PhD). These tech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Therapeutic inhibition of the oncogenic Wnt/beta-catenin pathway in mismatch repair deficient hypermutant tumors'.

assistant: **Innovation**

Colorectal cancer (CRC) is a leading cause of death worldwide. Mutations in components of the canonical Wnt/beta-catenin pathway such as APC, CTNNB1/beta-catenin, AXIN2 and more recently RNF43 or ZNRF3 can contribute to CRC tumorigenesis. The hosting team and Dr. Clevers’ group have recently described that inhibitors of the porcupine enzyme, that is essential for the maturation of Wnt-ligands, have therapeutic efficacy in tumors with RNF43 and ZNRF3 mutations. Hypermutant tumors are characterized by mutations in key components of the DNA mismatch repair (MMR) genes, resulting in the amplification in non-codifiying repetitive sequences in the genome known as microsatellites. Recent studies from the hosting team and Dr. Garraway’s group highlighted that mutations in RNF43 and ZNRF3 preferentially occur in a codifying microsatellite (hotspot) in MMR-deficient tumors. Lynch Syndrome is a hereditary cancer-prone disease where patients also develop MMR-deficient tumors as a consequence of germinal mutations in MMR genes accounting for 3-6% of CRC patients with very few therapeutic opportunities. In this proposal we aim to: 1) characterize Wnt-related genetic alterations in Lynch Syndrome patients and determine enrichment of RNF43 and ZNRF3 mutations compared to CRC sporadic tumors; 2) link MMR-deficiency and acquisition of the druggable Wnt-related mutations in RNF43 and ZNRF3; 3) evaluate the efficacy of PORCN/Wnt inhibitor WNT974 on tumors mutated in RNF43 and ZNRF3. We believe that not only Lynch Syndrome but any cancer patient with tumors presenting RNF43 and ZNRF3 mutations could benefit from the treatment with such new generation of Wnt/beta-catenin inhibitors. Our collaboration with the Oncology Service and pharmaceutical companies will accelerate the translation of ou