RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Harnessing the splicing code for targeted control of gene expression', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Alternative splicing (AS) of mRNA precursors plays important roles in tissue-specific gene regulation and biological regulatory mechanisms, as it can radically alter protein expression, cell phenotypes and physiological responses. Altered splicing also contributes to disease mechanisms, ranging from neurodegeneration to cancer. Drugs modulating AS have recently provided the first therapy for Spinal Muscular Atrophy, a common genetic disorder, illustrating the huge potential for treating many other diseases of unmet need, if only we understood the mechanisms controlling splice site selection and how to regulate them with small molecules. Unfortunately, despite decades of research, a comprehensive understanding of the mechanisms that control specificity of AS is lacking. This gap in basic knowledge prevents opportunities to harness splicing modulators as tools to study gene function, novel therapeutics or other biotech applications. This Project addresses head-on the major technical challenges that have limited progress in the AS field. Building on extensive preliminary data, we will use a multidisciplinary approach that combines chemical, structural, cellular, systems biology and machine learning to characterize mechanisms of splice site selection and identify targets for modulating these mechanisms using tool compounds. The outcomes will define key regulatory sequences, splicing factors and molecular interactions involved, thereby illuminating how the splicing machinery efficiently accommodates, yet also discriminates between, a wide range of splice site sequences. This will enable future applications harnessing splice site selection. Our primary goal is to answer the central question, ‘Is it generally possible to modulate splicing with high specificity using small mole
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Unravelling the genetic influences of reproductive behaviour and gene-environment interaction'.

assistant: **Innovation**

This project will be the first to engage in a comprehensive study of the role of genes and gene-environment (GxE) interaction on reproductive behaviour. Until now, social science research has focussed on socio-environmental explanations, largely neglecting the role of genes. Due to unprecedented advances in molecular genetics over the last two decades, for the first time in history we are able to examine whether there is a genetic component to reproductive outcomes, including age at first birth, number of children and infertility. Building on my substantive empirical research, I first develop a multifactor theoretical and measurement model isolating socio-environmental and lifestyle factors. Second, I apply the most cutting-edge techniques in genetics to examine the genetic architecture of reproductive behaviour, including: the first genome-wide association study (GWAS) of reproductive choice; polygenic risk scores; and, genome-wide complex trait analysis (GCTA). Third, I focus on gene-environment interactions (GxE) to test different mechanisms of how the environment moderates genetic influences. Fourth, I propose to use genetic markers as instrumental variables (IVs) in a bi-directional Mendelian randomization (MR) analysis to determine causality and address the endogeneity of lifestyle and education in reproductive outcomes. This transdisciplinary project will produce fundamentally different results, overturn established links and deliver major breakthroughs in fertility research and beyond. This project is not only ground breaking by setting a new research agenda, but due to the inclusion of  new genetic variables and  techniques to study the causal effects of genes and their interaction with environment, will yield major innovations useful  within demography and bey
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Graphene-based flexible perovskite solar cells for space applications' (GPSpace), addressing dissemination and exploitation.

assistant: **Impact**

The GPSpace project will address the use of graphene-based materials in solar cells for space applications, aiming to improve the stability of device architectures against the harsh environment in space. This research will evaluate the performance of graphene nanomaterials as electrodes and as interfacial layers regarding ultraviolet (UV) stability of metal halide perovskite solar cells under high vacuum. Additionally, this approach will contribute to the development of lightweight solar cells architectures with high specific power (EPw).


**Keywords:** Perovskite solar cells, graphene, interface engineering, inorganic and organic chemistry, space-based solar power
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Added-value for metallic coated products by new sol-gel process', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The AVCOP project (added-value for metallic coated products by new sol-gel processes) proposes to enable seven small manufacturing enterprising companies to re-define the product offer in the market for metal-finishing applications. The proposal seeks to combine nano-structured sol-gel coatings with ionic liquids for the first time to seal and protect anodised aluminium, hot-dip-galvanised steel and electroplated zinc. The traditional manufacturing sectors are experiencing significant threat from cheaper, low-quality and low-cost imports from lower cost economies. In the spirit of Europe 2020, the SME’s aim to respond through the exploitation of innovative surface treatments to offer the market levels of wear-resistance, corrosion protection and aesthetic appearance that exceed the best standards available today. The SME’s aim to derive significant benefits for their manufacturing processes by reducing the energy input for the anodising process by 50%, the elimination of all toxic pre-treatments from the galvanising process and the use of nano-structured, ionic-liquid-enabled coating systems, that will be entirely solvent-free. The SME consortium is drawn from member states from the four poles of the EU compass presenting a perfect representation of the developmental span for EU member states. All of the SME’s have experienced challenges through product substitution or replacement from inferior–quality imports and aim to respond proactively by drawing the leading research performers in the field of sol-gel chemistry for corrosion and wear protection and the emerging chemistry of ionic liquids
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of integrated modelling techniques to assess impacts of climate change on pathogens and water quality' under Seventh Framework.

assistant: **Concept**

Dr Rory Coffey graduated with an honours primary degree in Agricultural Science in 2003, he subsequently went on to complete a research masters and PhD in University College Dublin with a focus on Biological Systems Engineering. He is currently working as a Postdoctoral researcher in Ireland. The researcher is requesting funds for 3 years under the guidance of Professor Shane Ward, University College Dublin, Ireland. A two year outgoing phase will be spent working with Dr Mary Leigh Wolfe at the Centre for Watershed Studies, Biological Systems Engineering, Virginia Polytechnic Institute and State University, USA. Knowledge acquired during the outgoing phase will be transferred to the EU in year 3 during the return phase when Dr Coffey will rejoin the Bioresources Research Centre at University College Dublin.The overall scientific aim of the project is to apply watershed modelling techniques to integrate the effects of climate change on waterborne pathogenic organisms and transport of such substances to water sources (groundwater and surface water). Ongoing work in these areas is still in its infancy, and the project proposes a bottom-up approach to investigation.As the project progresses, the emphasis will shift from water quality monitoring techniques, theoretical modelling and simulation (relying on third country host expertise) to model development, application and evaluation within the EU (using home institutions expertise). The project will be completed with a view to environmental application and development of new protocols for water source protection (taking advantage of the home institution's experience in training, communication, scientific management, intellectual property, etc.)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project '1 MW DECENTRALIZED AND BUILDING INTEGRATED PV SYSTEM IN A NEW HOUSING AREA OF A CITY'.

assistant: **Objectives**

The project is a full scale demonstration of a 1 MW BIPV-system in an urban area of the Netherlands through the construction of 350 PV houses. Aims include : large scale demonstration of the technological and architectural potential of BIPV, cost reductions through optimised integration and economies of scale and the establishment of an infrastructure for future co-operation between key decision makers.Prefabricated PV-roofing and facade elements will be architecturally integrated into 350 hours in Amersfoort, Netherlands. Standard frameless PV modules supplied by 2 or 3 manufacturers will be used to provide a total system power of 1 MW. All houses will have standardised electrical designs, including individual inverters. The PV systems will be owned by REMU, although ownership may be transferred to the building owner in exchange for a financial contribution to the project. REMU will be responsible for the maintenance and operation of the systems for a period of 10 years. The size of the project has necessitated the redesign of the electrical infrastructure by REMU. The local authorities have ordered a consortium of project developers to develop the entire area of 5000 dwellings, schools etc. Monitoring will be done via the television cable network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'RV001: An anti-metastatic cancer vaccine'.

assistant: **Innovation**

Prostate cancer is the most commonly diagnosed cancer among men, with an anticipated 1.7M new cases and 499,000 deaths by 2030 worldwide. Although, most cancer therapies available focus on treatment of the primary tumor, the leading cause of cancer morbidity and mortality is metastasis. Today’s current treatments for metastatic prostate cancer focus on later stage of the cancer progression, when the signs of metastasis spread are already observed; and modestly prolong the patient’s survival and have serious side effects. Therefore, there is a high unmet need for new therapies, which can effectively address the problem as the first adjuvant treatment against early stage of metastasis in prostate cancer.RhoVac is a biotechnology company dedicated to the research and development of immunotherapies for the treatment of early stage metastatic cancer. The RV001 (RhoVac’s first product) vaccine is the first therapeutic vaccine against metastatic cancer cells, specifically targeting the prevention of cancer relapses. The concept behind RV001 relies on the reprogramming of the patient own T cells to recognise and eliminate early stage metastatic cancer cells.Together with an unprecedented therapeutic potential in multiple cancer types, RV001 holds important competitive advantages, such as safety, tolerability and cost-effectiveness. However, to secure swift development and successful commercialization, RhoVac needs partnerships and capital to achieve RV001 clinical validation. In this context, we believe SME instrument will be crucial to position RV001 within the metastatic cancer treatment and to confirm the high pharma-economic value of our disruptive technology. The accomplishment of SME Phase 1 and Phase 2 project objectives will maximize the clinical value of our vaccine wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'FUNCTIONAL GENOMICS STUDIES IN MARINE PRIMARY PRODUCTIVITY: ENVIRONMENTAL AND POLUTION EFFECTS ON PHYTOPLANKTON' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

One of the most serious challenges for humankind this century will be to understand how climate change (past, present and future) influences life in the oceans. It is known that marine phytoplankton carry out almost half of the global net photosynthesis of the planet. Therefore it will be essential to determine how climate change alters microbial metabolism. However, the integration of cell biology and genomics into oceanographic research is not sufficiently developed, even though biological (and especially microbiological) processes are fundamental for maintaining a functional biosphere.This project addresses the application of a novel molecular approach using genomics and metagenomics to elucidate metabolic activities under different conditions in the ocean in various groups of photosynthetic prokaryotes and eukaryotes. These techniques will also allow the rapid identification of candidate genes and facilitate the association of genes with specific metabolic and regulatory functions in different organisms spanning hundreds of millions of years of evolution. The initial phase of the project will investigate unicellular cyanobacteria using full genome microarrays analysis (outgoing). In a second phase, genomics studies will be done in diatoms, unicellular eukaryotes (return).The novelty of the proposed research lies in its interdisciplinary approach linking oceanography with cell biology and genomics. A key novel aspect of the proposal is the application of a comparative approach to very different groups of photosynthetic organisms, which will allow us to contrast the strategies of responses to environmental changes between them. This will improve our knowledge of the crucial roles marine microorganisms play in maintaining the well being of our planet. The successful im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Superconducting mesoscopic structures as possible elements of single flux quantum logic' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This proposal focuses on studying the feasibility of using superconducting finite antidot lattices of mesoscopic dimension as elements of a new single flux quantum logic. The 2x2 antidot arrays half filled by flux lines will be examined as the unit cell. The repulsion between the magnetic flux lines in the cells results in two bistable states and therefore binary transmission can be considered. A detailed study of the transport properties of the antidot lattices will be initially performed and the switching between its two bistable states will be analysed. Bilayer structures will be grown to investigate the possibilities of this quantum logic. The cells will be patterned in the top layer while the 'read and write' elements will be placed in the bottom layer. The new mesoscopic SQUID without weak links, developed by VSM at K.U. Leuven, will be tested as a non-interfering 'read' element.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of an AI-based algorithm for contrast agent dose reduction in magnetic resonance imaging' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In cranial magnetic resonance tomography (cMRT), the administration of contrast agent facilitates diagnosis of various pathologies such as metastases due to contrast agent enhancement. Patients undergoing a medically indicated cMRT receive 100% of the authorized contrast agent dose, i.e., 0.1 mmol of gadolinium per kg body weight. The main component of MRT contrast agent is gadolinium, which is a highly toxic rare-earth element, which has potential health side effects (inter alia allergic reactions and accumulation in the body) as well as environmental side effects (accumulation in the tap water).Due to the aforementioned issues, the reduction of contrast agent dose in cMRT is highly desirable. To tackle this issue, Katerina Deike-Hofmann from the Clinic for Neuroradiology at the University Hospital Bonn together with colleagues and collaborators from the Institute of Mathematics and Life Sciences developed an artificial intelligence (AI)-based algorithm that allows for contrast agent reduction called SmartContrast. Until today, more than 1.000 prospective data sets were acquired at seven different clinics and SmartContrast showed excellent generalizibility. Thus, Katerina Deike-Hofmann founded the relios.vision GmbH as a spin-off of the University Bonn to commercialize SmartContrast. Her goal is to advance the clinical standard by combining knowledge from the areas of medicine, mathematical image processing, computer vision, and artificial intelligence.


**Keywords:** Artificial Intelligence, Radiology, Computing, Software as a Medical Device, Deep Learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'PROMISERS: PFAS FREE POLYMER MATERIALS FOR PROTON EXCHANGE MEMBRANE (PEM)-BASED FUEL CELLS AND ELECTROLYSERS.'.

assistant: **Objectives**

The PROMISERS project goal lies in the advancement of new non per- and polyfluoroalkyl substances (PFAS) components for PEMFCs and PEMELs utilizing materials based on hydrocarbons and cellulose. The project will achieve this objective by focusing on developing multiple disruptive approaches for ionomers, membranes, electrode inks and MEAs which are free of PFAS. The project is aligned with sustainability principles, with no projected environmental barriers. Sustainable-by-design approaches and non-harmful materials will be targeted to ensure the environmental compatibility. Besides sustainability and zero pollution for the material fabrication also aspects such as safe-by-design, scalability and processing routes will be taken in account. PROMISERS represents a powerhouse consortium, including four major multinational companies: Syensqo (SOF, Chemicals and Polymers), Fumatech (innovative membranes for energy applications), Industrie De Nora (electrochemical industry) and RINA Consulting, two SMEs: Cellfion (sustainable membrane solutions) and Hysytech (engineering), two international research and technology organisations: Leitat, TNO, and an European university: IIT. PROMISERS will deliver and validate short stacks of PEMFC and PEMEL, targeting performances of > 1.5 Wcm-2 at 0.65 V for PEMFC and 3.0 Acm-2 at 1.8 V for PEMEL and with a degradation rate < 5 µV/hr. A techno-economic evaluation and exploitation plan will be executed to move from the technological concept (TRL2) to a laboratory scale multicell-stack (TRL4) PEMFC and PEMEL to ensure a fast-track for its commercialisation.


**Keywords:** PEMFC, PEMEL, non-fluorinated, sustainable, Clean hydrogen