RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Enhancing palliative care in ICU' to be submitted under Horizon Europe.

assistant: **Abstract**

About 10% of all decedents in the population die after admission to an intensive care unit (ICU). These patients often have distressing symptoms and may receive more intense life-prolonging treatment than they would have chosen, their family members often experience lasting distress from the experience and many ICU physicians and nurses are burdened by their perception of potentially non-beneficial care.The EPIC project aims to sustainably improve palliative care for critically ill patients and their families in the ICU. An interdisciplinary consortium collaborates to provide a novel harmonized palliative care practice model using telemedicine. The project is the first European interventional study on palliative care in the ICU, using a systems-based approach with proactive patient identification, checklist and blended learning targeted to specific requirements of ICU clinicians. Effectiveness of the new model is assessed through a stepped wedge randomized trial with 7 clinical centers from 5 European countries, 23 multi-disciplinary ICUs and enrolment of 2001 patients. Primary outcome is a reduction in ICU stay to relieve suffering. Cost implications and cost effectiveness will be assessed from different perspectives. An evidence-based patient decision aid for critically ill patients is developed. Additional outcomes serve deepen our understanding of barriers and facilitators and provide ethical recommendations for the use of telepalliative care in civic society. The vision of EPIC is to contribute to a mind shift from a narrow focus on prolonging life towards more holistic care. A European patient and family advisory group is implemented to engage patients and family members from the start and co-create open-access information to increase acceptance of palliative care
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Asynchronous Networks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Complex systems of interest in contemporary science and technology can often be viewed as networks of interacting subsystems or subnetworks. In the simplest, and so far most studied cases, subnetworks all run on the same clock, are updated simultaneously, and dynamics is governed by a fixed set of dynamical equations. In biology, especially neuroscience, and technology, for example large distributed systems, these assumptions often do not hold: components may run on different clocks, there may be switching between between different sets of network dynamical equations and, most significantly, components of the network may run independently of the rest of the network for periods of time. We say networks of this type are asynchronous. The project will develop a theory of dynamics on adaptive asynchronous networks with a focus on finding conditions imply predictability and functionality of the network, notably the avoidance of deadlock and race conditions. Methods will use techniques from the statistical theory of dynamical systems, networks, and stochastic analysis as well as ideas coming from correlation based learning and computational neuroscience. Among many applications, we remark the potential for significantly improved understanding of large distributed networks (both technological and biological), as well as dynamical system based models for qualitative computing, learning and pattern recognition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'NanoClassifier - QCM for rapid label-free Bionano interface evaluation and screening of effectiveness of nano-targeting strategies for therapeutics'.

assistant: **Concept**

Nanomedicine and Nanosafety rely on the same fundamental interactions between the nanoparticle interface and the biological milieu surrounding it, and it is this “corona” of proteins and other biomolecules that form at the bio-nanointerface that determines the fate and behaviour of nanomaterials.  Understanding, classifying and predicting nanoparticle coronas from their physicochemical properties offers a novel approach to screening for toxicity at early stages of product development and for regulatory purposes.This biomolecule corona also explains why many nanoparticle targeting strategies, that seem promising when tested under non-physiological conditions, fail when tested in vivo, where multiple competitive interactions occur, and where non-specific binding in many cases blocks the targeting functionality of the nanoparticles, rendering them inactive.However, despite the rapid increase of our understanding of the issues, methods by which to characterise the functioning bio-nanointerface in biologically relevant environments remain a challenge, and are time consuming and expensive.  The partners in the NanoClassifier IAPP project   are at the forefront of their respective areas and are pioneering new methodologies for study of complex questions in biologically relevant milieu and represent an optimal partnership to address this challenge.Together, NUID UCD and Attana AB will develop a cost effective, high throughput screening platform for characterisation of the bionanointerface and its cell-binding partners, to address a range of important questions currently hampering the implementation of nanotechnologies, both in medicine and generally in consumer products. The inter-sectoral nature of the project is critical to its success, as Attana AB bring their platform for k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Energy efficient High Performance Computing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Qarnot computing aims to develop a flexible High Performance Computing grid able to reuse the heat emitted by calculation units for the heating purposes of houses and business premises.Regularly, huge data centers are opened for storage or calculation of numerical data. Needs, including calculation power, are becoming increasingly important, which explains the creation and implementation of more and more of these data centers. However, the past few years have shown that these clusters are particularly energy-consuming not only because of the calculations but also because of the cooling systems.The idea is to sale processing power on the cloud. The calculations are smartly distributed to a remote computing grid. The grid is composed of calculation units that are actually electric heaters. The heat is produced by the processors that perform the computing.Qarnot computing sales cloud HPC on one end, and refunds  the electricity used by electric heaters on the other end. This solution allows Qarnot to build progressively a scalable computing grid avoiding the massive investments of a data center. Furthermore, there is no need to cool the infrastructure as the heat is directly used for heating purposes. Seasonality has already been taken into account by using CPU low power mode, install calculation units in strategic hosts such as schools that are closed during summer. In addition, computing power demand is seasonal, there is less jobs to perform during summer. Qarnot computing grid will be able to guarantee all year long a certain capacity, the extra power will be offered for free to universities and will be used as an adjustment variable (to meet the needs for calculation and the needs for heat).Qarnot can therefore propose a very energy efficient cloud HPC for reasonable
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'ADVANCED TOOLS AND METHODS FOR VIRTUAL ENVIRONMENT DESIGN AND PRODUCTION'.

assistant: **Concept**

A. Platform Development:I. Server SideL%1. Secure Access SystemL%2. Data Repository3. Versioning SystemII. Client Side1. Worlds Studio Platform  Client2. Worlds Studio Platform - Graphical User Interface3. MPEG-4 Viewer and Browser (2D such as JPEG, GIF, BMP, RGB and 3D such as VRML, MPEG-4-3D)4. Render Interface5. Maya to Virtools Exporter6. Maya to MPEG-4 Converter - Facial Animation7. Maya to MPEG-4 Converter - Body Animation8. Maya to MPEG-4 Converter - Text to Speech for Face AnimationB. Business Case/Demonstrator1. Proposition for Beijing Olympics2. Paris Air Show 2003C. Dissemination1. Internal Web Site2. External Web Site3. Project Brochure4. International RichmMedia2003 Workshop in Lausanne, Switzerland
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Alzheimer disease Related Functional Effects of the Urokinase-Type Plasminogen Activator (uPA) Gene PLAU' (ARFUPAG) targeting Sixth Framework.

assistant: **Abstract**

Alzheimer's disease (AD) is a complex neurodegenerative disorder that causes a progressive decline of cognitive abilities. Abundant evidence suggests that elevated amounts of the small highly amyloidogenic protein beta-amyloid (Aß) contributes to the neuro degenerative process in AD. Susceptibility loci for AD have been identified on chromosome 10q. Within the proximal region (~10q21-22), the plasminogen activator urokinase gene (PLAU) has been suggested as the strongest candidate due to its functional implication in plasmin generation, a serine protease capable of degrading Aß protein. Subsequent screening studies in multiple populations have identified an AD associated SNP within exon 6 of this gene (rs2227564).This SNP has also been shown to be associated with elevated plasma Aß levels in 24 extended LOAD families and with elevated plaque counts in autopsy confirmed cases. PLAU knockout mice have also been shown to present with elevated plasma Aß levels. However, the functional relevance of the PLAU gene t o AD in particular to Aß levels in the brain and related neuropathology needs to be examined in greater detail. Through the generation of a PLAU knockout-APP23 mouse model, the use of sRNA inhibition (RNAi) in primary neuronal cell culture from APP23 mice and the use of other state of the art technologies we hope to improve the current understanding, and determine the functional relevance, of the PLAU gene in AD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hydrologic Extremes at the Global Scale: teleconnections, extreme-rich/poor periods, climate drivers and predictability' (HEGS), addressing dissemination and exploitation.

assistant: **Impact**

Hydrologic extremes (floods and intense precipitations) are among Earth’s most common natural hazards and cause considerable loss of life and economic damage. Despite this, some of their key characteristics are still poorly understood at the global scale. The IPCC thus reports “a lack of evidence and thus low confidence regarding the sign of trend in the magnitude and/or frequency of floods on a global scale”. More generally, the space-time variability of hydrologic extremes is yet to be thoroughly described at the global scale. As a striking illustration, the recent initiative “23 unsolved problems in Hydrology that would revolutionise research in the 21st century” of the International Association of Hydrological Sciences includes questions such as: are the characteristics of extreme hydrologic events changing and if so why? How do extremes around the world teleconnect with each other and with other factors? Why do extreme-rich/poor periods exist?It is vital to fill these knowledge gaps to inform design, safety and financial procedures and to improve hazard preparedness and response. The project’s ambition is hence to better understand the global space-time variability of hydrologic extremes, using a three-pillar research strategy based on methodological innovation, extensive data analysis and proof-of-concept case studies. The specific objectives are to:1. Develop a statistical framework to describe the global-scale variability of extremes in relation to climate;2. Analyse global precipitation/streamflow datasets with the aim of quantifying teleconnections, spatial clustering, trends and extreme-rich/poor periods, along with their climate drivers;3. Explore practical applications such as global early warning systems allowing international disaster response organisatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Circuit mechanisms of fear vs. reward in the limbic system'.

assistant: **Concept**

Emotions are a central part of our mental self and health, playing a crucial role in guiding behaviors essential for survival. For instance, threats evoke fear and avoidance behaviors; conversely, rewards induce reward-states and approach behaviors. Resolving how the variety of emotions emerges in the brain remains a major challenge for modern neuroscience. The main objective of the proposed research is to investigate how opposite emotions like fear and reward are differentially processed in the limbic system. We hypothesize that these basic emotional states are encoded by interactions of neural circuits specific for negative or positive emotional valence and circuits for arousal. To address this problem, we will first aim to develop a novel genetic tagging approach for differential brain-wide screening for emotional valence and arousal circuits in a combined Pavlovian fear and reward conditioning task. Second, we will investigate how fear and reward are encoded in selected hotspots within this circuitry: by pharmaco- and optogenetic manipulations, we will test whether emotional states require the activity of, and can be induced by, a combination of valence and arousal circuits. This research will provide a circuit mechanistic framework for understanding the neural organization of emotions in health and disease and establishes a novel imaging method which will be useful for investigating other brain functions in a similar fashion.This postdoctoral project will significantly contribute to my career development by complementing my expertise in behavioral neuroscience with training in circuit neuroscience and by reinforcing my professional maturity and leadership qualities. Moreover, the reciprocal transfer of my expertise in behavioral neuroscience to the host laboratory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Systems Genetics of Heritable variaTions'.

assistant: **Objectives**

The complexity by which genotypes modulate phenotypic variation has been a major obstacle in understanding the basis of inter-individual differences. In the particular case of disease susceptibility, enormous efforts have been conducted among large consortia of quantitative geneticists, and a recent wealth of results showed both victories and frustrations. Victories because many genetic factors could successfully be linked to diabetes, heart failure, cancer, infectivity, and many other common diseases. Frustrations as it is becoming more and more apparent that genetic dissections are far from completion, with many unsolved questions especially regarding gene x environment interactions and incomplete penetrance. In this context, I propose to revisit the molecular basis of phenotypic diversity by addressing fundamental questions in a simple and powerful model organism: the yeast S. cerevisiae.Combining experimental biology and bioinformatics into a ‘systems’ approach, I propose 1) To reconsider our current view of genetic determinism. By examining the effect of genetic variation on single-cells, we will visualise how they shape probability laws underlying phenotypic outcomes. This will prepare us to the upcoming era of generalized single-cell analysis. 2) To investigate how chromatin epigenotypes affect phenotypic variations. We will characterize nucleosomal epi-polymorphisms and study their impact on transcriptional and phenotypic responses to environmental changes. This will establish whether and how individual epigenomes should be considered when planning trait dissections.This ambitious project is grounded on solid preliminary results and can be achieved thanks to my dual expertise in numerical science and experimental genetics. The questions addressed are fundamental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Low Energy And Near to zero emissions Ships' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The specific challenge for waterborne transport call MG4.1 is, “To support developments that make new and existing vessels…more efficient and less polluting”. A sound way to support developments is, to demonstrate solutions that are sufficiently close to market so that ship owners will consider these in their future investment plans. Following this reasoning LeanShips will execute 8  demonstration actions that combine technologies for efficient, less polluting new/retrofitted vessels with end users’ requirements. Demonstrators were selected for their end-user commitment (high realisation chance), impact on energy use/emissions, EU-relevance, innovativeness and targeted-TRL at the project end. Selected technologies (TRL3-4 and higher) address engines/fuels/drive trains, hull/propulsors, energy systems/emission abatement technologies. Technologies are demonstrated mostly at full-scale and evidence is provided on energy and emission performance in operational environments. The LeanShips partnership contains ship owners, shipyards and equipment suppliers, in total 48 partners from industry (81%) and other organisations. Industry has a leading role in each demonstrator. Target markets are the smaller-midsized ships for intra-European waterborne transport, vessels for offshore operations and the leisure/cruise market. First impact estimates show fuel saving of up to 25 %, CO2 at least up to 25%, and SOx/NOx/PM 10-100%. These estimates will be updated during the project. First market potential estimates for the  LeanShips partnership and for markets beyond the partnership are promising. Project activities are structured into 3 layers: Basis layer with 8 focused demonstrators (WP 04-11), Integration layer with QA, Innovation Platform and Guide to Innovation (WP02), Disseminatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Promotion and support to the implementation of the energy labelling for Space, Combi Heaters and Water Heaters with a focus on the “Package label”' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The ‘Label Pack A+’ project aims at supporting the implementation of the energy labelling of heating appliances while boosting its impact, the focus being on the “package label” and its potential to push for the uptake or renewable technologies, in particular solar thermal, in combination with more efficient conventional technologies.The project will address one of the main challenges related to this particular energy labelling process in relation to other Energy-related Products : the issuing of the package label by installers. This challenge involves the preparation of the industry, retailers and installers to this process, including the communication to the final consumer.Therefore, the main objectives of the project are to:- Provide guidelines, as well as standardized answers to clarify the responsibility of each actor in the supply chain. These activities will, in particular, focus on installers and SMEs, who might be facing specific implementation challenges;-> Facilitate the exchange of product fiches and product related information on the format of equipment’s databases, available to all the actors in the energy labelling process;-> Apply the energy labelling calculation methodology and make it available to all the actors in the supply chain in the form of a user-friendly online calculation tool; -> Develop and provide industry specific training material, especially focusing on the responsibilities’ and roles of installers in the energy labelling process;-> Provide tailor-made information for end consumers, which will either be directly accessible by them, or used by dealers to explain the significance and added value of the “package label”;-> Provide consolidated expertise on the energy labelling process to the Commission and national authorities, based on the