RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'PORTABLE AND FAST SURFACE PLASMON RESONANCE POINT-OF-CARE TEST FOR COVID-19'.

assistant: **Objectives**

The ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections has led to more than 7.031.249 cases and 403.112 deaths globally as of June 8, 2020.  Although most infections are self-limited, about 15% of infected adults develop severe pneumonia that requires treatment with supplemental oxygen and an additional 5% progress to critical illness with hypoxaemic respiratory failure, acute respiratory distress syndrome, and multiorgan failure that necessitates ventilatory support, often for several weeks.  Worldwide, infections and death from SAR-CoV-2 continue during June with more than 110.000 new cases every day despite lockdown in Europe and oversees. What started as a temporary sanitary issue, has morphed into a more permanent and long-lasting pan epidemic outbreak. One efficient manner to limit COVID-19 spreading and an adequate mean of better managing the COVID-19 outbreak is through unrestrained availability of fast, efficient, accurate and cost-effective point-of-care tests (POCT). Here we propose C-POCT-S, a rapid (<30 min), sensitive (200 vps/mL), selective (SARS-CoV-2), and inexpensive ( < 20 Euros) solution to address this medical need. C-POCT-S is  based on a combination of several technologies such as the use of COVID-19 specific nanobodies (VHH), magnetic nanoparticles with high magnetic strength and a VHH  modified interfaces, all integrated in a a hand-held surface plasmon resonance (SPR) based POC test (C-POCT-S) for the screening of the presence/absence of the SARS-CoV-2 virus in nasal and salvia samples. The aim of this project is to complete product optimization, performance validation in a clinical setting and manufacturing quality control for C-POCT-S and completion of its technical file, to enable declaration of confo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Trafficking transformations: objects as agents in transnational criminal networks' to be submitted under Horizon 2020.

assistant: **Abstract**

The Trafficking Transformations Project will use an innovative, multidisciplinary, object-centred framework to investigate the physical and contextual changes that illicit criminogenic collectables undergo during the trafficking process in three transnational criminal markets: antiquities, rare wildlife, and fossils. It will explore the socio-economic effects of the trafficked objects on participants in international criminal networks. It will transform organised crime research by shifting the focus of trafficking research away from criminals and networks of criminals toward following the objects of desire. Prior approaches to trafficking research cast trafficking as an interface between organised crime (people moving the objects) and white-collar crime (affluent people receiving goods); objects were not considered social agents in these networks. Trafficking Transformations pushes the boundaries of mainstream criminology, proposing an innovative object-centred understanding of trafficking networks, and exploring the ultimate question: How do objects cause crimes?The project will use object biography, a multi-sited ethnography technique, to investigate the influences and transformations of trafficked criminogenic collectables in international illicit markets. Through data collection at multiple sites along trafficking pathways, the transformations of criminogenic collectables, the networks that they create, and the people they influence will form a narrative, a biography of trafficking. This will reveal the hidden lives of illicit commodities prior to their appearance as objects of conspicuous consumption in public markets, and holds the prospect of destabilising existing assumptions about the formulation, maintenance, and disruption of transnational criminal networks,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The ERA Chair Culture as a Catalyst to Maximize the Potential of CEITEC' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The proposed ERA Chair project aims at supporting the on-going structural shift in the culture of the scientific community of Masaryk University by engaging a world-class scientific leader capable of inspiring positive change. Masaryk University has already been deeply involved in this process as the largest contributing member of the Central European Institute of Technology (CEITEC).CEITEC is a scientific centre in the fields of the life sciences and advanced materials and technologies with the aim of establishing itself as a recognized centre for basic as well as applied research. The CEITEC consortium includes the most prominent universities and research institutes in Brno in the Czech Republic. Thanks to EU Structural Funds, CEITEC is currently in a very rapid stage of development. One of the challenges facing our organization will be to maximize the high potential that CEITEC has at its disposal through cross-disciplinary collaboration.Within this proposal, we outline the intent to recruit an individual with the commitment to act as an agent of transformation to CEITEC and Masaryk University as a whole, and we will provide the eventual incumbent with a position and the means within the organisation to implement a robust cross-disciplinary program aimed at catalysing the creation of an open, dynamic scientific environment. Thus, we believe transformational leaders are an essential asset, not just for what they can achieve scientifically, but also how they can lead by example.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Life Long Learning for Visual Scene Understanding (L3ViSU)'.

assistant: **Concept**

My goal in the project is to develop and analyze algorithms that use continuous, open-ended machine learning from visual input data (images and videos) in order to interpret visual scenes on a level comparable to humans.L3ViSU is based on the hypothesis that we can only significantly improve the state of the art in computer vision algorithms by giving them access to background and contextual knowledge about the visual world, and that the most feasible way to obtain such knowledge is by extracting it (semi-) automatically from incoming visual stimuli. Consequently, at the core of L3ViSU lies the idea of life-long visual learning.Sufficient data for such an effort is readily available, e.g. through digital TV-channels and media-sharing Internet platforms, but the question of how to use these resources for building better computer vision systems is wide open. In L3ViSU we will rely on modern machine learning concepts, representing task-independent prior knowledge as prior distributions and function regularizers. This functional form allows them to help solving specific tasks by guiding the solution to ""reasonable"" ones, and to suppress mistakes that violate ""common sense"". The result will not only be improved prediction quality, but also a reduction in the amount of manual  supervision necessary,  and the possibility to introduce more  semantics into computer vision, which has recently been identified as one of the major tasks for the next decade.L3ViSU is a project on the interface between computer vision and machine learning. Solving it requires expertise in both areas, as it is represented in my research group at IST Austria. The life-long learning concepts developed within L3ViSU, however, will have impact outside of both areas, let it be as basis of life-long lear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mechanisms and Targeting Stromal Contribution to Tumour Invasion and Metastasis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Angiogenesis inhibition has proven to be a successful anti-cancer therapeutic approach and anti-angiogenic therapies are currently approved as standard therapy in several types of cancer for their clinically validated beneficial extension of overall survival, progression-free survival and/or time-to-progression in these cancer patients. Nevertheless, in preclinical mouse models of cancer, although these therapies also show significant anti-tumour effects and overall survival benefit, these therapies are also triggering increased tumour local invasion, with more distant dissemination and emergence of metastasis (overall tumour malignization).  The clinical relevance of this malignization effect in patients that are currently being treated with antiangiogenic drugs still remains elusive, but the frequent tumour relapses and acquired resistance to therapy in some patients strongly suggests this insidious event should be exhaustively evaluated.In this sense, many laboratories are rapidly advancing in the study of the molecular players and signalling pathways implicated in this event, although an important limitation of all these approaches is that they are all based on Tumour-centered studies of the causes of malignization and are not taking into account the Tumour Stroma contribution to tumour invasion and metastasis. Thus, we postulate that the tumour stroma indeed plays a critical role in malignization after anti-angiogenic therapies and its specific mechanisms should be determined in order to target these stromal components to impede tumour malignization after antiangiogenic therapies.STROMALIGN is a groundbreaking project designed to overcome these current limitations from a novel perspective: instead of focusing on the genetically instable and highly adaptive tumour c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SMART SPEED BUMP' (SSBUMP), addressing dissemination and exploitation.

assistant: **Impact**

Badennova (www.badennova.es), company created to develop and implement innovative products to help improve thesafety and quality of drivers, preventing accidents, and contributing to the health of its passengers, has developed a smartspeed bump (SSBUMP). The SSBUMP is a pioneer product in the road safety whose main objective is to serve as a speedlimiter for vehicles on any road. It is a smart and selective device since it is an obstacle only for those vehicles exceeding thespeed determined on a specific road and not affect to the vehicles that circulate respecting the speed limits.- The need to create a device with these characteristics is due to the serious deficiencies of the current speed bumps: Trafficaccidents; Back injuries; Damages to the vehicle; Environmental and Noise pollution; Damages in nearby properties;Negative effects on adjacent streets...The Smart Speed BUMP (SSBUMP) resolves all these deficiencies detailed before, because it is highly innovative, thanks totechnology patented worldwide by Badennova. The SSBUMP properties are achieved due to the non-Newtonian materialthat is contained in the SSBUMP, which liquid state is its usual mode, but at the time it receives an impact at high speed itpasses to a solid state until the end of the impact. In this sense, SSBUMP doesn´t offer any resistance to the drivers whorespect the speed indicated, on the contrary it is an obstacle for the drives that don´t respect the speed limit. This material isbiodegradable and nontoxic and non-polluting.The fabrication of the Smart Speed Bumps with our own technology, for subsequent B2B sale (via exclusive distributors) inthe international market. To do this, Badennova asks for the SME Instrument to finish the product to the 100%, and oncecompleted the SME Instrument set up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Protection without Ratification? International Refugee Law beyond States Parties to the 1951 Refugee Convention' in the context of a Horizon 2020 call.

assistant: **Objectives**

Many of the world’s top refugee-hosting countries have neither signed nor ratified the 1951 Refugee Convention. So do international conventions make a difference? The Refugee Convention represents a paradigmatic – and exceptionally timely – test of this theoretical and empirical puzzle, for refugee protection is increasingly politicized and has wide-ranging implications for state sovereignty.The BEYOND project fundamentally reconsiders the impact of international refugee law by developing the first genuinely global and systematic theoretical framework for understanding the behaviour and position of states that have chosen not to sign the Refugee Convention – especially those that still accept the lion’s share of the world’s refugees. These non-party states, overlooked by scholarship and seen as ‘exceptions’ to the international refugee law regime, are at the core of this project rather than the margins. BEYOND asks:1. What is the influence of the Refugee Convention in non-party states?2. How do these non-party states engage with and help create the international refugee law regime?BEYOND exposes and analyzes the various ways non-party states relate to international refugee law. It brings an innovative combination of methods to bear, including case studies on 4 of the world’s top 7 refugee-hosting states–Turkey, Lebanon, Pakistan and Bangladesh. The sub-projects investigate BEYOND’s two basic hypotheses: 1. The Refugee Convention has a significant influence on the behaviour of non-party states; and 2. Non-party states engage with, and help shape developments within, international refugee law.BEYOND sheds crucial, empirically grounded light on the prevailing assumptions about whether and why non-party states are exceptional. It also advances our theoretical and scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fibers' in the context of a Fifth Framework call.

assistant: **Objectives**

Fibres stand as the strongest and stiffest materials and constitute the critical component of composites, which are rapidly replacing traditional materials in structural applications. The outstanding fibre properties come from the strong ionic covalent or metallic bonds that sustain the load. As the ductility of these links is very limited, fibres are brittle and their ultimate strength is controlled by their fracture behaviour. Further improvements in fibre properties can be obtained through a deeper knowledge of the physical mechanisms involved in fibre fracture, and this is the main objective of the interdisciplinary workshop in fibre fracture. Evidently, improving the fibre properties will have significant consequences in the development of new composite materials with enhanced properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Slow relaxation and nonequilibrium dynamics in condensed matter' under Fifth Framework.

assistant: **Concept**

Slow relaxations, in the sense that the evolution time of the system becomes of macroscopic magnitude, are a common feature of many condensed matter systems. the best known examples being probably glasses, spin glasses and phase-separation systems. Systems with such slow relaxations are very often out of equilibrium, since a laboratory experiment generally takes place on time scales smaller than their relaxation time. This makes them very challenging systems to study, as usual statistical mechanic tools are insufficient. Since about 1990, a large number of advances have been made in our understanding of glasses and spin glasses.A number of new theoretical tools have been developed (dynamical mean field theories of spin glasses and structural glasses, models of spin glasses without disorder, replica approach to structural glasses), that begin to provide a unified view of systems that were originally thought to be intrinsically different. These new theoretical methods, together with more traditional approaches (trap models for the dynamics of disordered systems, the mode coupling theory of the glass transition, dynamics of randomly pinned systems) form a complex background, often difficult to grasp for a student or young researcher entering the field of dynamics of non-equilibrium systems. Moreover, the concepts mentioned above, although originally introduced in order to study glasses and spin glasses, are fInding an increasingly wide field of applicability. It is now commonly believed that they could be relevant for the description of systems as diverse as powders, foams, driven complex fluids. A recently organized workshop in Santa Barbara (Jamming and Rheology - Constrained dynamics on microscopic and macroscopic time scales, Fall 1997.} showed that a community in this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Re-designing zinc finger proteins by swapping alpha-helical domains with foldamer helices' to be submitted under Seventh Framework.

assistant: **Abstract**

Alpha-helices (aHs) are recurrent structures in proteins, whose folding properties, stability and function have been widely investigated. They often play the key role of recognition elements between proteins, or proteins and nucleic acids. These interactions are generally regulated by the strategic presentation of a few key residues on their surface. The efforts of many groups have been devoted to the synthesis of artificial molecules (foldamers), to mimic the structural complexity of natural helices, with the aim to reproduce their functions. A number of foldamer backbones has been synthesized to date, and their predictability and tunability constitute a great potential for their future applications. However, attaining more complex tertiary/quaternary structures through foldamers is still partially unaccomplished, and constitutes one of the ultimate goals in the field. This project will move a step forward towards the realization of this mission, by creating new composite proteins, swapping aHs with oligourea helices. The first target will be zinc fingers, a well described class of metalloproteins specialized in nucleic acid binding. Their peculiar folding, extensive structural characterization and biological relevance will be an ideal starting point to study the influence of the replacement of aHs with foldamers in this complex machinery. The new composite proteins will be tested to obtain insights into folding, metal complexation, DNA binding ability and cellular behavior of these new entities. This project will form a bridge between the expertise of the applicant in the chemistry of DNA targeting, and the host in oligourea foldamers. A further collaboration with a specialist in metallopeptides will provide the appropriate combination of knowledge required for this m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pathogen-phage cooperation during mammalian infection' in the context of a Horizon 2020 call.

assistant: **Objectives**

Most bacterial pathogens are lysogens, namely carry DNA of active phages within their genome, referred to as prophages. While these prophages have the potential to turn under stress into infective viruses which kill their host bacterium in a matter of minutes, it is unclear how pathogens manage to survive this internal threat under the stresses imposed by their invasion into mammalian cells. In the proposed project, we will study the hypothesis that a complex bacteria-phage cooperative adaptation supports virulence during mammalian infection while preventing inadvertent killing by phages. Several years ago, we uncovered a novel pathogen-phage interaction, in which an infective prophage promotes the virulence of its host, the bacterial pathogen Listeria monocytogenes (Lm), via adaptive behaviour. More recently, we discovered that the prophage, though fully infective, is non-autonomous- completely dependent on regulatory factors derived from inactive prophage remnants that reside in the Lm chromosome. These findings lead us to propose that the intimate cross-regulatory interactions between all phage elements within the genome (infective and remnant), are crucial in promoting bacteria-phage patho-adaptive behaviours in the mammalian niche and thereby bacterial virulence. In the proposed project, we will investigate specific cross-regulatory and cooperative mechanisms of all the phage elements, study the domestication of phage remnant-derived regulatory factors, and examine the hypothesis that they collectively form an auxiliary phage-control system that tempers infective phages. Finally, we will examine the premise that the mammalian niche drives the evolution of temperate phages into patho-adaptive phages, and that phages that lack this adaptation may kill host pathogens