RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'From Bildung to Learning Society. Philosophical Foundations and Mutations of a Modern Ideal' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The main objective of this project is to compare the modern philosophy of Bildung and the contemporary paradigm of the Learning Society (LS) by systematically analyzing their homological structures. Through this comparison, we aim to expose the important conceptual mutations of the ideal of educational autonomy occurring from the first paradigm to the latter.    This research combines history of philosophy and political philosophy and will follow a plan in four steps:  1. Historical reconstruction of the constellation of texts formed around the concept of Bildung in classical German philosophy, through an original typology of the contrasting positions of the main authors of this period, from Herder to Humboldt.  2. Identification and analysis of the most significant critical transformations of the Bildung concept by influential philosophers since the second half the 19th century.  3. Establishment of a corpus of scientific and political texts and discourses on the LS, for comparing the paradigm of LS to the modern philosophy of Bildung following an analytical grid pointing the conceptual and normative homologies and mutations between them.  4. Concrete application of this systematic comparison and testing of the heuristic potential of the Bildung philosophy in the particular context of the current debates on the transformations of the Idea of University.   The novel aspects of the this project are twofold:  (a) To provide an innovative comparative method for systematically analyzing the contemporary mutations of modern philosophical concepts. (b) To lay the foundations for a comprehensive philosophy of University and academic freedom.   Through an analysis of political-educational narratives, we will show that the great narratives of the philosophical modernity – such a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modulation of CFTR stability and function from the extracellular space' under Seventh Framework.

assistant: **Concept**

The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) is a unique ABC protein functioning as a chloride channel. It consists of two transmembrane and two nucleotide binding domains, and a regulatory region. The cftr gene is mutated in cystic fibrosis, an inherited disease of high morbidity and mortality mostly affecting people with European ancestors. So far more than 1,500 mutations are known affecting the stability or the function of the protein that results in the lack of functional channels in the cell membrane. This leads to imbalanced water and salt homeostasis affecting the function of all organs with secretory epithelia. Therefore it is important to develop therapeutic agents to stabilize CFTR and restore its function. This is being done by blind screening resulting in compounds that are hydrophobic and act on either the transmembrane or intracellular parts of the protein. In this study we aim to modulate the stability and function of CFTR from the extracellular side. The advantage of this approach is the targeting of the hydrophilic extracellular loops that enable structural studies and design of water soluble drugs with advantageous toxological properties. We will employ cutting-edge computational approaches combined with solid experimental methods to gain insights in the structure and dynamics of the larger extracellular loops in CFTR. The effects of the extracellular loops on the conformation of the transmembrane region and the protein function will be studied that will establish a basis for rational drug design. Our preliminary results indicate that the extracellular loops possess stable secondary structural elements and changes in their conformation can either stimulate or inhibit the protein function. Together, the extracellular loops will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fermentation of food products: optimised lactic acid bacteria strains with reduced potential to accumulate biogenic amines' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Lactic acid bacteria (LAB) play an important role in the production of fermented food by dairy and wine industries. Decarboxylation of did- and tricarboxylic acids by LAB is a desirable step resulting in the production of compounds which enhance the organoleptic properties and/or the stability of the finished products .However, decarboxylation of amino acids (e.g. histamine, tyrosine) leads tithe production of bioorganic amines (BA) (e.g. histamine , tramline) which have undesirable toxic properties. The goal of the present proposal is to acquire anon-depth understanding of the individual acid, and amino acid decarboxylationpathways, to obtain strains unable to produce BA and to generate aroma producer strains resistant to acid stress. We aim to develop strains and systems for the food industries to avoid health risks of EA by controlling their production and, in parallel, to improve the beneficial citrate/maltase decarboxylating pathways
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'The world’s first collaborative professional 3D design tool'.

assistant: **Objectives**

Gravity Sketch plans to build the world’s first collaborative 3D design tool for professional designers in which cross-functional teams can work together in real-time. Project Orchestra will build a platform accessible through VR, laptops, tablets and phones, allowing teams of designers, managers, engineers, and marketers to create and collaborate together on the same design in real-time, and then export directly to industry-standard computer-aided design (CAD) software for further refinement.This reduces the 2D stage of the design process, along with the manual translation to CAD, and drives significant cost savings in design-intensive industries by providing up to 90pct efficiency savings in workflows.Orchestra targets the needs of the transportation, industrial, and consumer product design industries, along with the very large film and computer games markets.Building a software platform to achieve real-time creation and collaboration requires a vast technical leap from anything now available in the market, because the challenge of manipulating and rendering 3D data in real-time becomes exponentially larger with each additional participant. But the global market for such a tool is multi-billion-Euros in size and the challenge is solvable by leveraging Gravity Sketch's proprietary technical know-how. We already have as clients design teams from some of the largest automotive manufacturers in the world, and over 20,000 professional SME and freelance customers. Project Orchestra expands this footprint to transportation as a whole, architecture, consumer products, footwear, and to large film and game studios. At the same time, it expands the target user base from designers to all stakeholders involved in the design process.Gravity Sketch has a multinational team of indust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'APPROAcH: Antimicrobial and Save 3D-Printable Polymers for Oral Health' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A major problem in dental care restorations is bacterial infiltration. Bacteria between the tooth and the restoration is a potential cause of postoperative sensitivity, pulp inflammation, and necrosis. In orthodontics, the formation of biofilms during treatment bears the risk of enamel decalcification, cavity formation, and gingival inflammation due to the fact that colonized bacteria are extremely hard to remove in presence of orthodontic appliances. Another related problem is that the current fabrication of dental restorations and braces is labor intensive, requiring highly skilled technicians. Recently, steps have been taken to change the traditional workflow and introduce 3D printing (3DP) technology in this field. 3DP enables a more patient specific way of working, increasing the quality of dental care on the one hand and reducing the costs on the other hand. To address both problems, a highly innovative 3DP antimicrobial polymer system for applications in dentistry and orthodontics will be developed in this proposal. Since the materials will be in contact to or incorporated into the body, attention needs to be paid to render these systems non-toxic and biocompatible. Second, the commercial, IPR and business opportunities of these novel materials will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Sustainable, Biobased and Bio-Inspired Materials for Smart Technical Textiles' (SUBBIMATT).

assistant: **Innovation**

In SUBBIMATT we will develop a novel generation of biobased and bioinspired sustainable smart technical textile materials to address current and future energy needs. We start from developing debondable adhesives, bio-polyurethane and negative thermoresponsive materials. Complementing these with existing (but tuned) biobased materials will enable circular textile intermediate products: high end coated fabrics, nanomembranes and shape memory filaments. Subsequently, these textile intermediates will be the stepping stone for making bioinspired Smart Textile Materials (STM) featuring mechanical actuation, energy harvesting and tuneable fabric openness. Lastly, the novel bio-STMs will be implemented in three demonstrators with integrated energy harvesting: shape morphing building envelopes, automotive interior textiles and advanced garments with adaptable breathability.The Safe and Sustainable by design (SSbD) framework will be applied, developing a protocol for technical textiles development. Combining modelling and experimental characterisation will allow to optimise the development of the STMs and demonstrators, predicting their safety, functionality and energy harvesting capabilities. For the demonstrators we plan to integrate complimentary elements (e.g. sensors, batteries or supercapacitors) resulting from other projects (via liaison). SUBBIMATT results will help to find more sustainable ways for covering the most important consumer living standard needs: energy, sustainability and comfort. The demonstrators will be products that citizens use on a daily basis, thus helping to increase visibility and impact. That way, we aim to create a positive momentum for the novel generation of smart biomaterials and for their application in bioinspired technical end-uses, thus help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Research of efficient materials for the negative electrodes of ni-mh battery' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The main aim of the present project is to produce new materials which can be used as negative electrodes of MH batteries with a better storage capacity than the currently used ones. LaNi5 compounds have reached today industrial seal production, however their capacity is limited to 370 mAh/g The search for increased capacities leads now to investigate new families of alloys like body-centred cubic vanadium based solid solutions, because they have larger theoretical hydrogen storage properties. It is worthy to remark that Ni-MH batteries are nowadays economically competitive and much more friendly with nature than the currently employed batteries. Preliminary experiments carried out at Dr. Percheron-Guegan's lab have shown that the compound Ti0.21 V067 Nio Ni0.12 give a reversible electrochemical capacity dose to 500 mAh/g. Therefore, we propose to investigate the ternary system Vanadium Titanium-Nickel to optimise not only the hydrogen loading capacity but also hydrogen activation and electrolyte corrosion, problems. The alloys will be synthesised by conventional induction melting or mechanical alloying They will be characterise. by optical metallography, electron probe micro-analysis and X-ray diffraction in order to verify the number, nature composition and homogeneity of the present phases. Their hydrogenation behaviour will be studied both by volumetriv measurements and by electrochemical techniques. Training content (objective, benefit and expected impact) The training content of this proposal will allow me to gain experience in the field of metal hydride batteries, the use of electrochemical techniques, and the development of new intermetallic compounds. This fact together with my present stay in Germany working on thin film hydrides
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of complement in the induction of autoimmunity against post-translationally modified proteins' (AUTOCOMPLEMENT).

assistant: **Innovation**

In many prevalent autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) autoantibodies are used as diagnostic and prognostic tools. Several of these autoantibodies target proteins that have been post-translationally modified (PTM). Examples of such modifications are citrullination and carbamylation. The success of B cell-targeted therapies in many auto-antibody positive diseases suggests that B cell mediated auto-immunity is playing a direct pathogenic role. Despite the wealth of information on the clinical associations of these anti-PTM protein antibodies as biomarkers we have currently no insight into why these antibodies are formed.Immunization studies reveal that PTM proteins can induce antibody responses even in the absence of exogenous adjuvant. The reason why these PTM proteins have ‘autoadjuvant’ properties that lead to a breach of tolerance is currently unknown. In this proposal, I hypothesise that the breach of tolerance towards PTM proteins is mediated by complement factors that bind directly to these PTM. Our preliminary data indeed reveal that several complement factors bind specifically to PTM proteins. Complement could be involved in the autoadjuvant property of PTM proteins as next to killing pathogens complement can also boost adaptive immune responses. I plan to unravel the importance of the complement–PTM protein interaction by answering these questions: 1) What is the physiological function of complement binding to PTM proteins?2) Is the breach of tolerance towards PTM proteins influenced by complement?3) Can the adjuvant function of PTM be used to increase vaccine efficacy and/or decrease autoreactivity?With AUTOCOMPLEMENT I will elucidate how PTM-reactive B cells receive ‘autoadjuvant’ signals. This insight wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Performance and qualification tests of lubrication system equipment', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

ULB-ATM will adapt its current test benches for lubrication equipment to the new requirements imposed by the CROR application. The lubrication equipment to be tested are lubrication pumping units (one at a time or several together), oil tanks, heat exchangers and various associated components as filters, valves and other accessories like sensors or monitoring devices.All tests will be performed with the double objective of validating the design of the lubrication components as well as characterizing their performance with the qualification requirements in mind.ULB-ATM has already obtained the qualification of its test benches from Techspace Aero for his ""clean oil"" lubrication test bench and his ""polluted oil"" test bench.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pd(II)-catalyzed direct Csp3-H functionalization of amines: a new platform for the synthesis of privileged molecules' (II) under Seventh Framework.

assistant: **Objectives**

Chemical synthesis, as central science, has a tremendous impact in Society by providing highly valuable compounds as new materials, drugs, sensors or sources of energy. Today, the way we get through those molecules is still a problem to solve. The development of novel methodologies for their efficient and straightforward construction is very relevant for Society, in the short, medium and long term. The last decade has seen the development of a new reactivity concept, taking advantage of the ubiquitous of C-H bond. The direct functionalization of this bond brings forth a more economical and faster way for the derivatization of organic compounds. Consequently, the design of metal catalyzed C-H bond functionalization has become a flourishing area in organic synthesis. This proposal details a design blueprint for palladium catalyzed direct Csp3-H bond functionalization of amines without the presence of any directing group. This will constitute a significant breakthrough in the field of metal catalyzed C-H bond functionalization allowing that “unfunctionalized” molecules become synthetic intermediates in synthesis. To achieve our goal we propose the use of easily accessible cyclic hindered amines as a new versatile platform for the functionalization of Csp3-H bonds. These cyclic cores are easily synthesized from the corresponding ketones and amino alcohols and therefore, after the corresponding functionalization step following by deprotection, we could access to γ-functionalized amino alcohols and β-functionalized ketones. Thus, the same chemical platform would allow us to functionalize two different families of important chemical compounds highlighting the impact that the technology presented in this proposal could have in the organic chemistry field. The work will therefor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Computational study of hydrogen storage in metal-doped materials' under Seventh Framework.

assistant: **Concept**

The efficient storage of hydrogen is the bottleneck in the development of fuel-cell powered vehicles. Currently, technical targets for hydrogen storage capacity have not been met by any existing technology. The European Union has set research needs for hydrogen storage in very high priority in view of the expected benefits of fuel cells in facing the global warming problem. Experimental studies have concluded that a promising method for storing hydrogen is by adsorption in metal-doped porous materials. Physically, in this method, the metal nanoparticles cause dissociation of hydrogen gas and H atoms subsequently migrate to the porous adsorbent. The phenomenon is called spillover and its mechanism is currently not understood. We aim to use a multi-scale modeling approach, consisting of ab-initio DFT calculations, Monte Carlo simulations and macroscopic modeling, in order to: a) Understand the mechanism of spillover and the effects of material properties and operating conditions. b) Quantify the capacity of hydrogen storage by spillover on a variety of metal-doped porous materials, including graphitic materials, carbon nanotubes, carbon foams, graphite-oxide materials, metal-organic frameworks and covalent-organic frameworks) c) Predict materials that would be expected to have high hydrogen storage capacities through the mechanism of spillover.