RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Generative Artificial Intelligence in Population Genetics' (PopGenAI), addressing dissemination and exploitation.

assistant: **Impact**

Understanding the demographic history of populations and species is essential, as it plays a critical role in conservation and breeding programmes for both wild and domesticated species. However, inferring demographic history from genetic data faces the problem of model non-identifiability, where different demographic histories fit the genetic data equally well. This issue is amplified by the use of summary statistics instead of complete genetic data. Addressing the model non-identifiability problem is fundamental for improving the precision of demographic inference, particularly in complex cases involving multiple independent admixture events or barriers to gene flow.This project aims to resolve the problem of model non-identifiability in demographic inference by developing a generative artificial intelligence (AI) tool that can uncover histories that are indistinguishable when a particular summary statistic is used. This generative AI will serve three core purposes: (1) identify non-identifiable demographic histories, helping researchers better understand the range of possible historical events that could explain the data; (2) apply this tool to clarify complex demographic histories in domesticated species, such as cattle, providing more accurate insights into their genetic background and informing breeding programmes to maintain genetic diversity; and (3) detect barriers to gene flow in recently diverged species, offering deeper insights into local adaptation and speciation processes valuable for conservation.By addressing the model non-identifiability problem and applying this approach to key biological questions, this project has the potential to transform the study of demographic history in population genetics and open new perspectives for research on species evol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Sublinear algorithms for the analysis of very large graphs'.

assistant: **Innovation**

Large graphs appear in many application areas. Typical examples are the webgraph, the internet graph, friendship graphs of social networks like facebook or Google+, citation graphs, collaboration graphs, and transportation networks.The structure of these graphs contains valuable information but their size makes them very hard to analyze. We need special algorithm that analyze the graph structure via random sampling.The main objective of the proposed project is to advance our understanding of the foundations of sampling processes for the analysis of the structure of large graphs. We will use the approach of Property Testing, a theoretical framework to analyze such sampling algorithms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Identification of novel effectors of the Type Six Secretion Systems in Pseudomonas aeruginosa' to be submitted under Seventh Framework.

assistant: **Abstract**

Pseudomonas aeruginosa is a human pathogen causing life-threatening nosocomial infections. Its virulence mechanisms are pleiotropic, but secretion systems have a key role in transporting effectors, toxins and other virulence factors from the bacteria into the environment or target host cells. In recent years, a novel secretion system, the Type VI secretion system (T6SS), was shown to be important for P. aeruginosa virulence. Of three T6SSs encoded on the P. aeruginosa genome, the H1-T6SS is important for P. aeruginosa to compete with other bacteria and to establish chronic infections. H1-T6SS is involved in the secretion of at least three bacteriolytic effectors, Tse1-3, whereas no effectors have been identified for H2- and H3-T6SS. We hypothesise that proteins secreted by these two systems mediate other important aspects of P. aeruginosa virulence and their identification and characterisation are crucial to further understanding the H2- and H3-T6SS function and P. aeruginosa pathogenesis. This project will identify these effectors, using three approaches: 1) identification of regulatory elements controlling H2- and H3-T6SS gene expression in order to up-regulate expression of the H2- or H3-T6SS clusters and other co-regulated genes; 2) analysis of H1-, H2- and H3-T6SS gene expression in biofilm conditions using flowcells; 3) identification of H2- and H3-T6SS secreted effector proteins via secretome analysis of strains that have up-regulated expression of H2 and H3-T6SS clusters. The discovery of these secreted factors will be a breakthrough, since only a very limited number of T6SS substrates have been identified. It will give new insights into P. aeruginosa virulence and could be exploited for development of new therapeutic options.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development and characterisation of novel materials for hydrogen storage' (MATERHY), addressing dissemination and exploitation.

assistant: **Impact**

Hydrogen storage is considered to be the key challenge in achieving a hydrogen-based economy. The long-term solution for many applications like in vehicles is hydrogen storage in solid materials. Light-weight complex hydrides are considered as the most promising materials. This proposal is focused on hydrogen storage in selected novel boron-based complex hydrides based on alkali and 3d/4d transition metals, so-called mixed borohydrides. The proposal addresses synthesis of novel compounds by advanced ball milling, characterisation with respect to thermodynamics, kinetics and structure and studies of the effect of catalysts. The researcher from Hiroshima University has a significant competence in methodology related to ball milling and thermal characterisation of novel complex hydrides. The host institution, IFE, has a significant experience in hydrogen storage materials, and in particular structural studies of such compounds. A major goal of the project is a transfer of knowledge related to novel methods for synthesis and thermal characterisation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Endothelial metabolism dictates the bone marrow niche and the plaque microenvironment' (ENDOMET-STEER) under Horizon Europe.

assistant: **Objectives**

Inflammation is an important driver of atherosclerosis, the primary cause of global morbidity and mortality in emerging and developed countries. New strategies to reduce atherosclerotic cardiovascular disease (CVD) risk are therefore eagerly needed. I recently found that atherogenic inflammatory stimuli rewire cellular metabolism in endothelial cells (ECs) and thereby contribute to atherosclerosis progression. Defining the intricate link between EC inflammation, metabolic rewiring and functional consequences for the vasculature will open new avenues for therapeutic strategies in CVD. My recent work shows that CVD-associated metabolic changes in ECs can affect their secretome. In turn, the endothelial secretome disrupts both stem cell function in the bone marrow niche and macrophage activation in the plaque microenvironment, two highly vascularized tissue compartments that drive atherosclerosis progression. Based on these findings, I hypothesize that CVD-associated EC metabolic changes impact the micromilieu in both tissue compartments, propagating the proinflammatory state in CVD patients.With this ERC project I aim to define (1) how EC metabolism is affected in atherosclerosis, (2, 3) what the impact of altered EC metabolism is for stem cell function in the bone marrow niche and for macrophage activation in the plaque, and ultimately (4) to define how interventions in EC metabolism improve tissue function and halt CVD development.I will apply innovative 3D organ-on-chip models that accurately reflects the human bone marrow and plaque microenvironment. By combining this with a unique collection of human ex-vivo atherosclerotic plaques, human bone marrow cells and novel transgenic in-vivo models, I will generate essential new insights that help to understand the developm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Partnership, Leadership and Assessment Network for HPC' under Seventh Framework.

assistant: **Concept**

PLANETHPC is Framework 7 Support Action designed to bring together the HPC community in Europe and beyond to exchange knowledge, to identify shared and complementary goals and to identify the research challenges ahead. This will culminate in the production of a research roadmap which outlines research priorities for the mid to long term.The project involves establishing a free-to-join network of members (PLANET), and providing facilities enabling them to share knowledge. These will include providing an on-line forum for exchange of ideas, establishing special interest groups, organising events such as workshops for knowledge exchange and publicising the network.  Members of the network will gain value via interactions with other members and through support activities such as newsletters and opportunities to contribute to the recommendations that the project will make in the research roadmap  The project will be carried out by a single partner, EPCC, the supercomputing centre at The University of Edinburgh, for reasons of efficiency and simplicity. The activities of the project will be overseen by an invited expert group.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FLEXIBLE SENSOR CO-OPERATION FOR STRUCTURAL HEALTH DIAGNOSIS/PROGNOSIS' under Seventh Framework.

assistant: **Concept**

Safe operation of structures requires rapid and early detection of structural degradation. A potential approach is to monitor structural degradation in real-time, including damage/facture due to unforeseen circumstances, by deploying sensors and efficient/effective wireless mesh networks throughout the structure.  This proposal addresses the development of suitable combinations of sensors to monitor damage and their prediction during an aerospace structural component’s service life. Diagnostic and prognostic algorithms will determine the damage evolution (initiation/propagation) and damage type (i.e., delamination). The research will also focus on the development of models to predict failure evolution using FEM-based progressive failure analysis that considers the effect of defects and uncertainties not anticipated during design stage. This would cover in-service accidental damage, tracking of repairs and monitoring of sensor changes reported during transmission. Flexible, low-cost, easy-to install solutions for autonomous ad-hoc monitoring will be assessed. This project will to determine the feasibility of coordination of data from heterogeneous sensors, with special focus on improving the wireless transmission of data. The aim is to determine and validate the type, number and arrangement of sensors needed to characterize a given structural damage scenario.  This project will cover five key topics: 1) Assess and design the architecture of a smart and flexible wireless sensor network for multiple sensors with on-board processing, 2) Design and fabricate prototype sensor modules for selected candidate sensors. The process board will be designed for all sensors so that only one board is necessary with each sensor interfacing the wireless chip, a micro controller and a mem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'From Geometry to Combinatorics and Back: Escaping the Curse of Dimensionality' (GeoScape).

assistant: **Innovation**

Combinatorics is a fundamental mathematical discipline whose study has experienced unprecedented growth during the past few decades. Its rapid development can be partially explained by spectacular applications of extremal combinatorics in additive number theory, information theory, theoretical computer science, and elsewhere. Asymptotic results in extremal and probabilistic combinatorics have proved to be powerful tools in the structural and algorithmic analysis of huge networks such as the internet graph, brain maps, social networks, and integrated circuits. We have deep, well developed algebraic, topological, and probabilistic techniques to tackle some basic problems of modern combinatorics, but many classic Ramsey-, Turán-, and Szemerédi-type questions remained open.   The main goal of the proposed work is to attack some hard problems for large classes of graphs and hypergraphs arising in geometric, algebraic, and practical applications. These structures escape the ""curse of dimensionality”: they can be embedded in a bounded-dimensional space, or they have small VC-dimension, or a short algebraic description. The work of the principal investigator, his collaborators and students has played a significant role in the introduction of modern combinatorial tools in geometry. In the present project, he aims to explore the reverse direction: to develop and apply geometric techniques to settle important special cases of notoriously difficult combinatorial problems on (1) bounded degree semi-algebraic graphs and hypergraphs, (2) graphs and hypergraph of bounded VC-dimension, (3) ordered graphs, 0-1 matrices, and graphs embedded in the plane or in other surfaces. Progress on the problems described in the proposal is expected to lead closer to the solution of some classical pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Ground European Network for Earth Science Interoperations - Digital Earth Community'.

assistant: **Concept**

Digital Earth is a visionary concept for the virtual representation of the Earth that is spatially referenced, interconnected with the world's digital data repositories, and encompassing all its systems and forms, including Earth Sciences, Natural Resources Management, Environmental Monitoring system and human society dimensions. The project will establish open data and services access, allowing European and worldwide Digital Earth Communities to seamlessly access, produce and share data, information, products and knowledge. This will create a multi-dimensional, multi-temporal, and multi-layer information facility of huge value in addressing global challenges such as biodiversity, climate change, pollution and economic development. GENESI-DEC evolves and enlarges the platform developed by the predecessor GENESI-DR project by federating to and interoperating with existing infrastructures. GENESI-DEC will:Enlarge the GENESI-DR infrastructures in terms of both resources availability and geographical extent.Provide guaranteed, reliable, easy, effective access to a variety of data, facilities, and applications to an ever increasing number of scientists and users.Harmonise operations at selected key infrastructures limiting fragmentation of solutions and assure that the access to data and resources is secure and controlled, according to policies.Enable multidisciplinary collaboration among communities and the creation of user-configured virtual research facilities.Integrate new scientific and technological paradigms in operational infrastructures in response to the latest Digital Earth requirements.Stimulate, educate and support the creation of virtual research communities.GENESI-DEC involves key partners of ESFRI projects and collaborates with key actors of Digital Ear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Palaeomagnetic fingerprinting of oceanic terranes in old orogens - the Caledonides as a test case', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The collision and subsequent suturing of oceanic terranes to continental margins during orogeny is a well documented feature of modern orogens. However, the recognition of oceanic terranes in older orogens has proved to be problematic due to the often ambiguous nature of their faunal, sedimentological and geochemical signatures. In cases where the convergence between these various elements is predominantly latitudinal the palaeomagnetic technique can prove successful. I therefore propose to carry out palaeomagnetic studies in five possible oceanic terranes in the European Caledonides with a view to: (1) Identifying those which are truly oceanic and (2) Constructing separate terrane drift-histories for these oceanic terranes. These studies will not only yield new constraints on the evolution of the European Caledonides but will also test models of terrane accretion, hence contributing to global issues of crustal evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'At the Margins of Equality: A Theory of Vulnerability to Social Exclusion' (MESE) under Horizon Europe.

assistant: **Objectives**

The COVID-19 pandemic has exposed our shared vulnerability to isolation, serving as a reminder that relations of marginalization and exclusion constitute significant obstacles to the achievement of a society in which everyone can fully participate and stand in relations of equality with each other. Moreover, empirical research has shown that marginalised individuals are being disproportionately disadvantaged by the Coronavirus emergency in several ways: they are the target of stigmatization and discrimination. And, although they are more likely to experience mental health issues and are typically exposed to serious health risks, they are not provided access to the same degree of medical care as other members of society.  The current socio-political state of affairs, then, vividly illustrates how persons' vulnerability to social exclusion is one of the most pressing social justice challenges that liberal democracies must face. Building on my previous research on the justification and the value of equality, in this project I will contribute to the Horizon Europe strategic plan towards ""creating a more resilient, inclusive and democratic European society"" by developing the first-ever comprehensive liberal egalitarian theory of vulnerability to social exclusion in analytical political philosophy. This theory will define the rights that marginalized individuals have to be fully included as equals in society and identify the social arrangements that the state ought to put in place in order to ameliorate their social condition. In our current pluralist and diverse societies the call for social equality is ubiquitous but its precise meaning is contested. By providing an account of what shape equality takes when applied to socially marginalized groups, this research will thus