RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Direct observation of ligand binding and channel gating on individual ligand-gated ion channels', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Understanding the dynamics of ligand-gated ion channels is essential for understanding synaptic processes and neuronal signal integration (neurotransmitter gated channels) and intracellular signalling (cyclic nucleotide gated channels). Here we will combine single molecule fluorescence detection, with single channel electrophysiology, to detect ligand-binding and follow subsequent channel gating simultaneously. Single-channel patch-clamp alone can only measure two experimental states and their development in time: open and closed. Still, given some assumption, such data permitted construction of detailed kinetic models. Fluorescence detection can determines whether ligands are present or not, and the kinetics of the binding process. However, the nature of the ligand (agonist or antagonist) is not directly accessible. It was suggested more than 10 years [Edelstein 1997], that combining the two approaches on the single-molecule level will gain insights into the receptor mechanism. We will combine the two approaches to directly link the two molecular functional determining events (ligand binding and channel gating) within one experiment. Recently we implemented a combination of confocal single molecule fluorescence detection with single channel patch clamp, and showed (on the example of nAChR and fluorescent epibatidine) that such experiments are technically possible and feasible [manuscript in preparation]. We identified two parameters as limiting for the achievable time resolutions: counting noise and ligand diffusion into the confocal volume. Scope of this project includes: (1) identifying and analyzing biological systems with kinetics accessible to this approach, (2) developing techniques to reduce the time limitation, in particular the use of FRET to avoid the diffusi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pilot-scale hybrid roll to roll/sheet to sheet manufacturing chain for flexible OLEDs' (Flex-o-Fab) targeting Seventh Framework.

assistant: **Abstract**

Organic Electroluminescence (OLED) is the most promising technology to deliver flexible, thin, light weight, power efficient and environment-friendly light sources. Currently glass based OLED devices are slowly entering the market place, opening new possibilities for lighting solutions. By adding flexibility and robustness at a lower price point, flexible OLEDs will change the lighting industry and revolution the way we all experience lighting.<br/>The introduction of flexible OLED lighting is hampered by a lack of reliable series production technologies, flexible OLEDs exist in the lab but not yet in the fab. Roll-to-roll (R2R) manufacturing of these devices is seen by many as the future cost-efficient manufacturing technology for flexible OLEDs. However, complete roll to roll manufacturing of flexible OLED is still years away and will not be able to bring flexible OLEDs to the market place within 10 years.<br/>The overall objective of the Flex-o-Fab project is the demonstration of a reliable manufacturing process for OLED lighting foils enabling market introduction within 3 years after the end of the project.<br/>Flex-o-Fab will take existing technologies in use for the manufacturing of glass based bottom emissive small molecule OLEDs and use these as a basis to develop a pilot series manufacturing process for flexible OLEDs.  By doing so, the project will be allowed to focus on the roadblocks and bridge the gap between sheet-to-sheet (S2S) produced glass OLEDs and the future envisioned complete R2R lighting foils.<br/>Flex-o-Fab will strengthen and expand the leading position of the European lighting industry by making the shift from lab to fab and make flexible OLED devices an industrial reality. Furthermore, the new sustainable disruptive technologies will create l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Energy leading-edge technology for high performance gear shaping machines' (E-Optimum) under Horizon 2020.

assistant: **Objectives**

E-Optimum (‘Energy Optimum’) is a leading-edge technology for gear shaping machines, leveraging the latest engineering progress in terms of design and motorization, which guarantees an optimum quality of end product while offering wide margins of improvement in terms of energy savings and operational & maintenance (O&M) cost reductions. The pioneer of the mentioned innovation is Comur S.r.l., a fast-growing and historical family business founded in 1983, specialized in the manufacture of gear-hobbing and shaping machines, providing special tooling and fixtures for any kind of application. After more than 50-year experience, Comur is one of the most important key players within the Italian industrial gear market. Our revolutionary technology is set to change the entire industry, as it addresses the current limitations of gear shaping machines that are extremely energy consuming, non-flexible and pollutant since they lack an ecological post-process compatible with current technologies. The use of E-Optimum will allow our clients, first of all in the automotive sector, to reduce energy consumption of the main motor by 11kW (40%), and decrease operation & maintenance costs by 25% and 15% respectively. Fully aligned with our technical and commercial strategies, E-Optimum will contribute to boost the growth of Comur. With our cutting-edge solution, we estimate to achieve an accumulated revenue of €11,160,000 deriving in an accumulated profit close to €3.27M by 2025 and a Return of investment (ROI) of 4.87.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biological Impact of Benzoxazinoid Metabolization by a Specialist Root Herbivore' under Horizon 2020.

assistant: **Concept**

Some herbivores can sequester and use plant secondary metabolites for their own defense. Despite many examples of sequestration, the impact of these compounds on herbivore performance and natural enemy resistance in still not well understood, especially for root herbivores. The objective of this project is to investigate the biological relevance of benzoxazinoid N-glycosylation by the western corn rootworm Diabrotica virgifera virgifera, one of the main pests of maize that sequesters benzoxazinoids from maize roots. To reach this aim, the project will combine mass spectrometry imaging with environmental RNAi and ecological assays to understand how the formation of N-glycosylated benzoxazinoids affects herbivore performance and resistance to entomopathogenic nematodes. This will be the first study to investigate the relevance of secondary metabolite sequestration in a root pest through molecular manipulation. This project will shed light on the importance of plant defense sequestration for root-feeding insects, for plant-insect interactions and for crop protection.


**Keywords:** Plant-herbivore Interactions, Western Corn Rootworm, Maize, Sequestration of Plant Secondary Metabolites
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Smartphone Measured Eye-Based Digital Biomarkers for Drug Use Detection' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Drug addiction is a global problem; nearly 30 million illicit drug users worldwide suffer from problematic drug use.  Kontigo Care AB is developing an innovative medical device – Previct Drugs - a robust, app-based, eHealth-platform for place unbound, continuous, voluntary, self-monitoring of drug use. It will constitute an add-on to Kontigo Care’s current eHealth offer developed for management of other addictive disorders (alcohol abuse and hazard gambling). Using smartphone cameras, patients suffering from drug addiction, will be identified, and asked to record a 10 s long video of their eyes. Analysis of eye biomarkers associated with pharmacodynamically induced pupil reactions (pupillometry) will yield instant results on drug use/sobriety. Our unique, disruptive Internet of Thing (IoT)-based approach is designed to combine continuous monitoring of drug use and daily mood/cravings, with communication tools aimed at improving the impact of distance care. Real-time results become instantly available to caregivers through our cloud-based Care Portal, allowing fast interventions and correct patient prioritisation. This eHealth solution will drive healthcare digitalisation resulting in extreme cost-efficiency of out-patient treatments as well as convenience and complete privacy during drug screenings. A sophisticated AI-system will assess personal risks of relapse and transform addiction management to become proactive instead of reactive. This approach has the potential to enhance personalised therapy outcomes by ensuring that help can be provided fast to the patients who need it the most. The project objective is to prepare for commercialisation of the Previct Drugs module by determining the most efficient routes for gaining clinical and market acceptance by validating t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Ports as Energy Transition Hubs' (POTENT).

assistant: **Innovation**

In February 2023, the President of the European Commission highlighted a unique generational opportunity for the European Union (EU) to secure its industrial leadership in the growing net-zero industrial value chains. The EU is committed to spearheading the twin transitions of digitalisation and energy system transformation and turning skills into high-quality jobs. The POTENT (‘Ports as Energy Transition Hubs’) doctoral training network will explore the strategic role of Europe’s ports in this transition. It brings together a multidisciplinary network of academic and non-academic partners to provide interdisciplinary and inter-sectoral research training for 15 doctoral candidates (DCs). The training is structured into thematic work packages: 'Transition Infrastructure', 'Socio-Techno-Economic Analysis', and 'Port Governance and Business Models'. POTENT is designed as a leadership and inclusion platform with an encompassing approach for securing gender equality in recruitment, supervision and training, and in research design. The DCs are supervised by at least three academic and one non-academic supervisor. Academic supervisors are primarily Category A Researchers, guaranteeing high-quality research training. Non-academic supervisors serve primarily in mid-management and executive roles in world-class organizations across the energy transition system. Guided by Innovative Doctoral Training principles, POTENT strengthens excellence, interdisciplinarity, global mobility and networking – incorporating 15 academic and 18 non-academic secondments. The key innovative aspects of POTENT include state-of-the-art knowledge integration and multidisciplinary research. The programme offers robust career development support through a combination of local, network, and external skills
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Optimized oxidoreductases for medium and large scale industrial biotransformations'.

assistant: **Concept**

The INDOX proposal on industrial oxidoreductases aims to provide relevant industrial case stories to demonstrate the efficacy of optimized biocatalysts on targeted reactions, and to establish the processes scalability, sustainability and cost-efficiency versus chemical conversion processes. The chemical industry (specialties excluded) is not yet embracing enzymatic oxidation reactions to a significant extent primarily due to lack of biocatalysts with the required selectivity, availability and compatibility with the rigorous process conditions. Selected industrial oxidation and oxyfunctionalization target reactions form the basis for the INDOX screening and optimization of new biocatalysts, including: i) Intermediates for agrochemicals/APIs; ii) Polymer precursors and functionalized polymers; and iii) Intermediates for dye-stuffs. The project flow comprises: i) Recovery of selective biocatalysts from the groups of heme-peroxidases/peroxygenases, flavo-oxidases and copper-oxidoreductases from fungal genomes and other sources; ii) Improvement of their oxidative activity and stability by protein engineering (using rational design, directed evolution and hybrid approaches combined with computational calculations) to fulfill the operational and catalytic conditions required by the chemical industry; and iii) Optimization of reaction conditions and reactor configurations (including immobilization technologies and new enzymatic cascade reactions). Finally the cost efficiency compared to chemical processing will be evaluated. The INDOX approach is supported by a highly-specialized consortium of SMEs, large companies and research/academic institutions. Production of the new optimized biocatalysts and their introduction into the chemical market will take advantage from the partici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Research to Reality: Digital Solutions to European Challenges' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

The event, organised by the Belgian regions represented by the Department EWI from the Flemish Government, Innoviris from the Brussels capital region government, and SPW Economie from the Walloon government, aims to bring together researchers involved in research on digital technologies within the Horizon Europe programme, implementers involved in projects from the Digital Europe Programme, and policy makers working on digital policy at regional, national, and European levels.The primary goal is to discuss policy and practical challenges hindering cooperation between the two framework programmes, particularly in terms of digitalisation. To ensure diverse perspectives, there is a strong emphasis on making this event interactive. Other objectives include fostering networking among different target groups, reviewing the functioning of the Digital Europe Programme, and providing a platform to showcase best practices in cooperation and synergy between the two framework programmes.The event is scheduled for the 5th of February 2024 in Brussels, with visits to relevant organisations in Belgium planned for the following day.Overall, the event aims to create a dynamic platform where researchers, implementers, policy contributors, and other stakeholders can converge, exchange ideas, and contribute to the advancement of digitalisation initiatives in Europe.


**Keywords:** Digitalisation, Research, Digital Europe Programme, Horizon Europe, digital, synergy, policy, Europe, Europe's Digital Decade, strategic autonomy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Hexafly Black Soldier Fly Protein and Oils for Fishfeed' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Hexafly’s innovative solution provides the proteins and oils needed for nutritious feed profiles through the bio-conversion of agricultural waste with little or no nutritional value into a viable feedstock through the breeding of Black Soldier Fly larvae. These are then processed into a protein meal rich in amino acids, and a nutritious oil loaded with omega 3, 6 and 9, this oil has recently been verified as having a nearly identical profile to coconut oil. Within the very same process, the shells of the insects are separated from the insect proteins in order to increase their digestibility, which is then converted into the valuable chitin commodity. Hexafly use their innovative Bio-Conversion technology to up-cycle low value vegetative waste from various industries converting it into high value sustainable natural commodities providing an environmentally friendly cleantech solution to many of the serious problems and issues facing the Animal Feed and Fertiliser Markets. Hexafly’s insect based oils and protein provide a much more ecologically friendly feed source than fishmeal or soymeal, providing more nutritional value, and without requiring the use of any arable land. It is a highly sustainable procedure utilising bio-conversion of agricultural waste to produce a high quality source of nutrition with a minimum carbon footprint. Hexafly’s innovative solution contributes to the green circular economy by reducing reliance on wild fish stocks, while promoting the sustainable growth of existing aquaculture to meet growing human consumption demands. In addition, its adoption will reduce reliance on soy which takes up excessive amounts of arable land, of which may be channelled instead to alternative crops or directed for human consumption. When compared to current market s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'First adaptive eyewear to offer perfect vision for people with myopia and progressing presbyopia'.

assistant: **Concept**

Eyesight is our most critical sense providing over 80% of our sensory impressions, but in the modern world people’s eyesight has become significantly worse. It is the result of irreversible megatrends of increasing indoor lifestyle with high use of digital devices and aging population. While the former affects the development of young eye causing shortsightedness, then population aging leads to higher prevalence of inevitable aging related farsightedness. Moreover, with an aging population, economies increasingly rely on an aging workforce among whom the prevalence of both vision problems is continuously expanding. To prevent this problem from weighing down people’s productivity as well as their personal wellbeing, Pixieray introduces breakthrough adaptive eyewear technology to effectively provide perfect vision for those whose eyes are naturally not up to it anymore. While progressive eyewear with static lenses is currently the primary remedy for correcting near and far sight vision, they severely limit field of clear vision for different distances, create peripheral vision distortions and cause physical discomfort through dizziness and neck strain. In contrast, Pixieray uses its proprietary liquid crystal lens technology combined with the world’s smallest and power efficient IR based eye tracking solution to dynamically adjust eyewear’s optical power given the user’s viewing distance and prescription strength. This allows the wearer to see clearly at every distance with full field of vision and without distortions and physical discomfort.


**Keywords:** Adaptive eyewear, tunable liquid crystal lens, IR eye tracking, myopia, presbyopia