RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A Fibroblast-Targeting Advanced Lead Mitigating Inflammation and Fibrosis in IBD' to be submitted under Horizon Europe.

assistant: **Abstract**

Inflammatory bowel disease (IBD), which comprises Crohn's disease (CD) and ulcerative colitis (UC), is a growing global health challenge affecting over 6.8 million people. Characterized by chronic inflammation leading to intestinal fibrosis, IBD significantly reduces quality of life and increases the risk of severe complications, including colon cancer. Current treatments primarily target inflammation, and fail to address the persistent activation of inflammatory fibroblast phenotypes and the resulting fibrosis, contributing to frequent relapses and a heightened risk of disease progression.To address this gap, FIBROLEAD introduces a pioneering approach by targeting fibroblasts, key mediators of chronic inflammation and fibrosis in IBD. Our recent research identified VM-313 to effectively disrupt pathogenic fibroblast activation. We now have evidence that this compound has a strong potential in mitigating both inflammation and fibrosis in vitro, ex vivo and in a mouse model of lung fibrosis. Additionally, it exhibits a favourable safety/toxicity profile and drug-like properties that are equal or superior to currently available anti-fibrotic drugs. These findings position VM-313 as a promising candidate for expanding and improving therapeutic strategies for IBD and other fibrotic diseases.This PoC project aims to develop VM-313 as an advanced lead and validate its clinical and commercial potential. Our approach includes assessing its in vivo safety and efficacy in animal models of IBD and determining its mode of action via target identification and validation studies. In parallel, we will develop a comprehensive business case, engage with key stakeholders, and conduct a commercial assessment to evaluate market entry potential. By leveraging our unique targeting strategy a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Machining of very hard materials for tool and die manufacturing' (1994-1998).

assistant: **Concept**

Actually at mid-term of the project, the development of the hard milling technology for the finishing of molds have been achieved according to the objectives of the project. Based on the partners' input a geometry was designed which could be machined successfully for one material. The process reliability for the roughing and pre-finishing of hardened steel with a hardness above 54 HRC up to 64 HRC is limited due to insufficient performance of the cutting tools and not adapted machining strategies in state of the art CAM systems. New cutting tools with small diameters were developed to machine special features of the test geometry.Machining of hardened steel has experienced a considerable growth potential over the past years. It poses a competitive alternative to EDM, that is characterized by the need of electrode design and manufacturing, and removal of the heat affected zone. This process chain still accounts for most of the long and costly manufacturing cycles in tool and die shops. It could be shortened significantly in many cases by using milling instead of EDM. The CRAFT-project Machining of very hard materials in tool and die manufacturing is designed to substantially enhance the performance of these milling processes through focused development of applicable hard machining technology. An increased usage of milling versus EDM on selected geometries and materials will result in higher productivity and lower manufacturing costs. It will increase the competitiveness of the participating European enterprizes in their field of business. The enterprizes are representing machine tool builders, tool manufacturers and tool and die makers from Sweden, Denmark, Germany, Spain and Portugal. All companies have a vital interest in the advancement of hard machining technology, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'THE ENIGMA OF SUPERSOLIDITY'.

assistant: **Innovation**

A « supersolid » is a quantum solid inside which a fraction of the mass is superfluid. The coexistence of solid and superfluid properties is paradoxical and its understanding is a challenge attracting many research groups since its discovery in helium by Kim and Chan in 2004. The existence of anomalies in the rotational inertia of solid helium around 100 mK has been confirmed. They are accompanied by a peak in the specific heat and by astonishing anomalies in the elastic properties. It is now generally accepted that supersolidity is due to the presence of disorder in the samples: dislocations, grain boundaries, helium 3 impurities &However, in our opinion, nobody understands how which kind of disorder is responsible for the observed supersolidity. Although the characterization of disorder in solid helium samples is a difficult task, we have a long experience of crystal growth in helium and a dilution refrigerator with optical access which allows direct observation of the crystals during their growth, an essential control of their quality. We know how to prepare either polycrystals , disordered single crystals or very high quality single crystals. We propose to study the elastic properties and the rotational inertia of solid samples with known disorder. In most previous experiments one had to guess what was the crystal quality. With dc-flow experiments and ion mobility measurements, we also propose to investigate the predicted superfluidity of grain boundaries and dislocation networks. After clarifying the respective role of defects and impurities in solid helium, and thanks to the international collaboration we propose, we should be able to progress in the understanding of supersolidity, hopefully to discover its nature.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Enhanced digital cinema' (EDCINE) targeting Sixth Framework.

assistant: **Abstract**

EDCINE focuses on the optimisation; enhancement and interoperability issues of Digital Cinema based future standards. JPEG-2000 compression and the DCI specifications" document are the cornerstones of the project's efforts.The "DCI specifications" document published in July 05 confirms the SMPTE decision to choose JPEG 2000 instead of MPEG for digital cinema coding doesn't take into account many European issues. The MXF file format and security tools specifications are being adopted following the DCI studios' wishes. They lead to large files because of the lower compression rate but allow larger colour space, better resolution and bit-streams adaptable in quality and resolution. To continue to be able to project digital content, cinemas will have to comply with those requirements within a few years.EDCINE will push the limits of the SMPTE specifications by including quality optimisation, robustness to transmission errors, content security tools, stereoscopic imaging, interactive access, forensic marking and metadata for indexing and retrieval. The project will also supply interoperability with equipments using transcoding to/from MPEG and insure end-to-end security from production to projection and to the others content distribution markets (e.g. television, mobile devices, internet). Networked access to cinema archives allows users optimised access of video data for retrieval and downloading.EDCINE will demonstrate that interoperable solutions between the DCI requirements and the European digital cinema needs may be found. EDCINE developments will be actively pushed at the SMPTE, JPEG and EBU standard bodies where the partners are already active, directly or through the European Digital Cinema Forum (EDCF).The EDCINE project will do more than putting Europe at the fore
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Archaeological soil micromorphology of early prehistoric and ethnographic sites' (GEOARCHAEOLOGY).

assistant: **Concept**

We propose to apply the technique of archaeological soil micromorphology to a selected group of European and Asian prehistoric sites, and of African ethnographic sites, with the goal of reconstructing original contexts of hunter-gatherer activities that w ill lead us to approach the lifestyles and behaviour of our prehistoric ancestors.The project proposed focuses on the Early Palaeolithic, a crucial timeframe that encloses the roots of human evolution and the earliest dispersals that led to the first human settlement of Europe. This research, which comprises an innovative line of investigation, is possible now thanks to present-day technological advancements together with the recent discovery of a number of sites in Europe and Asia dating to 1.8-0.5 million years ago.The proposer is an experienced researcher from Spain specialized in archaeological soil micromorphology. She has previous experience with and permitted access to the prehistoric sites relevant for the project, as well as to the living contexts of the Hadza, a small hunter-gatherer community in Tanzania. The host institution for this project will be the Economies, Societes, Environnements Prehistoriques (ESEP) laboratory of the Maison Mediterraneennes des Sciences de l'Homme (MMSH).This laboratory has a specific area devoted to Geoarchaeology with the necessary space, equipment and experienced personnel. The research will be carried out in close collaboration with Dr. J.-P. Brugal (host institution), France, and will include the use o f a series of related geochemical techniques with which the researcher will become familiarized.This undertaking will represent an outstanding step forward in the professional career of the researcher, as well as her definitive incorporation into the European scientific commun
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Light-responsive microalgal living materials' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Nature fabricates materials with remarkable properties, having the ability to grow, move and sense their environment. Such dynamic and interactive materials are in strong contrast with man-made synthetic materials. Recent scientific interest has emerged to incorporate living cells into materials to form living materials, using most often muscle cells or bacteria. While underexplored, microalgae-based living materials are highly promising due to the light-driven movement of microalgae. The aim of this ERC project is to develop the first microalgae-based photosynthetic living material with a dynamically light-controllable shape and with locally tuned (mechanical) properties.  The fabrication of light-responsive microalgal living materials will be possible through novel fundamental knowledge that we will gain regarding the growth and motion of microalgae within a porous hydrogel. Although this constrained environment mimics one of the microalgae natural habitats (soil), we have limited understanding of the microalgae behaviour within such an environment. We will first investigate how cells move within a porous environment and how they respond to light, with the goal of using light for 3D patterning. We will then explore how the hydrogel-based living material can be locally mechanically reinforced with cell-secreted polymers, and finally how to harness the microalgae light response as a mean to create a soft actuator.  My independent research team uniquely combines expertise in microalgae cell biophysics and in engineered living materials, and we are thus ideally positioned to take on the challenge of creating microalgae-based living materials dynamically controlled by light. This ERC project opens up a new class of materials with life-like functionalities such as shape cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Ways Forward for Space Traffic Management' (SPACEWAYS).

assistant: **Innovation**

SPACEWAYS intends to create a common understanding of the guidelines and standards necessary to develop a Space Traffic Management (STM) concept for the European Union (EU). It also aims to assess European technical available and required capabilities (notably in the field of SSA/SST technologies) with respect to STM requirements; and to provide a set of STM best practices and recommendations in line with EU interests. This includes the preservation of a safe, secure and sustainable space environment as well as the reinforcement of European sovereignty and competiveness.Over its 18-month duration, SPACEWAYS’ first objective will be to analyse the policy, legal and economic context of STM. It will aim to better understand the STM concept’s dynamics worldwide and its consequences for Europe. While key space powers may attempt to create norms and regulations for future STM, SPACEWAYS intends to provide guidelines to support European policy making thereupon.In parallel, another goal will be to assess European capabilities and technology gaps with respect to future STM requirements. SPACEWAYS will identify stakeholders and users’ needs by associating them to the project through a networking platform. It will also proceed to a complete analysis of technical needs defined by future STM possible regulations. Both SSA/SST capabilities and technological developments related to new space missions and functions will be analysed. Here, specific attention will be devoted to mega constellation management, on-orbit operations or launch and re-entry future activities.These parallel lines of work will converge to produce a set of STM guidelines and best practices fully compatible with EU interests. They will be disseminated to relevant communities, to support the EU, as a major space and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New methods for efficient second harmonic generation in waveguides - use of pulsed laser treatments to control the ferroelectric domain structure' to be submitted under Fourth Framework.

assistant: **Abstract**

This project has the goals of fabricating waveguides in LiNbO3 and LiTaO3 with a controlled ferroelectric domain structure in two different ways, with the final objective of efficient Second Harmonic Generation (SHG). In the first part, the goal is to achieve periodic reversal of ferroelectric domains by using pulsed thermal excitation with laser pulses. With this novel laser technique it is expected to directly obtain the periodic pattern; this will be used for Quasi-Phase-Matching SHG. In the second part, by Laser Ablation Technique I will deposit and diffuse thin films that will create large and gradual changes in the Curie Temperature with the goal of obtaining, inside the waveguide, an alternative domain structure in the transverse direction to the surface (by alternative poling at the different temperatures). This will improve the overlap between either guided mode or to Cerenkov mode.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'STREAM - Sonar Technology for Remote Environmental Monitoring' (STREAM) under Horizon 2020.

assistant: **Objectives**

Oil and gas is continuously leaking from offshore deepwater infrastructure. Up to 1 million tonnes of oil are lost from deepwater drilling leaks each year, with 601 oil and gas releases reported in the North Sea in 2015 alone, up 14.5% on the previous years. Current leak detection technologies suffer from high false positives, high cost, lack of continuous monitoring and safety risks, meaning the majority of leaks are not detected by equipment. To address this major environmental and economic problem, we have developed STREAM, a unique technology which uses subtle changes in the speed of sound to detect contaminants in seawater. We have recently completed a funded project to technically prove our concept at TRL6. SALT has a proven track record of successfully commercialising highly innovative technologies such as our award-winning SonarBell. We have also successfully led two European collaborative projects to exploit the SonarBell in different applications. Currently, we are in advanced discussions with Statoil and BP who have shown great interest in the STREAM technology. Crucially, we are in negotiations with Subsea7, a global tier 1 service provider, to include STREAM in their service offering. We now need to validate the market opportunity and reduce commercial risk by running large scale trials and optimising our product performance. 5 years post-project, we will generate annual revenues of €31.8 million, €4.7 million in net profits, 282 jobs, representing an 8 x ROI to EC investment. STREAM will significantly reduce the catastrophic impacts of undetected oil and gas leaks on marine ecosystems, fisheries and aquaculture by helping producers effectively detect leaks and meet stricter industry legislation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Platform for ATM Tools Integration up to pre-Operation' (PATIO) targeting Fourth Framework.

assistant: **Abstract**

The PATIO project will develop an evolutionary and adaptable experimental platform to efficiently support the tools integration and validation activities of the ATM authorities, industry and R&D community.It will cater for the suitability for tools integration and validation up to a pre-operational level, from a general and functional viewpoint. It will provide a sufficient degree of realism in the ATC or environment functions to support pre-operational activities, including the representation of various levels of ATC system integration, provision for the use of ATN and the coupling of systems external to the core ATM environment as airport or military ones. Simulation as well as operational data will be used to assess and validate the tools against a wide variety of situations. A set of standard interfaces and commonly agreed set of basic functions will be defined. The time horizon will cover the 3rd phase of EATCHIP and EATMS by means of easy adaptations to different operational concepts, airspace structures, cluster of tools and HMIs. The real-time and fast-forward simulation will be amongst the features of the PATIO platform which will also include flexibility, modularity, portability and scalability, this allows a widespread set of experiment up to full-scale experiments when integrating the tools for pre-operational testing. The ease of interconnection will allow the coupling with other simulation facilities (ATC simulators and aircraft simulators) and its enlargement for the overall ATM validation process (prototypes and mock-ups). Its development will proceed through an incremental approach with two major increments: a minimum platform composed of initial middleware version and low-level functionalities to provide the basis for the other components integration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Crustal structure of iceland - confronting the current controversy withintegrated geophysics'.

assistant: **Concept**

Research objectives and content Geoscience research has yielded two contrasting hypotheses for the structure of the crust and upper mantle in Iceland: a traditional 'thin crust' model and a rival 'thick crust' model. This project will test both hypotheses and determine the 'true' structure beneath Iceland. This fundamental research challenge will significantly advance our understanding of geological processes in Iceland and of mantle plumes. It will contribute to understanding volcanic activity and geothermal resources. A wealth of geoscience data of various kinds exists for Iceland, including seismic, gravity and magnetic data. In addition, new results are flowing rapidly from the Iceland Hotspot project, led by Univ. Durham, U. K., that is collecting earthquake recordings on a dense seismometer network covering all Iceland. It is now urgent to integrate all available geoscientific data to derive a self-consistent model for Iceland. Training content (objective, benefit and expected impact) Objective: To acquire Post-doctoral research experience on a challenging project, thereby establishing myself as a researcher. Benefit: I will develop further the integrated geophysical approach of my Ph.D. topic and extend my skills to new techniques of geophysical data processing. Impact: The work will contribute to a subject of great international interest and will generate a comprehensive model for Iceland that will be of use to many subsequent researchers. Links with industry / industrial relevance (22)