RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The neural representations of person identity information: fMRI and neuropsychological investigations' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Person recognition is critical for appropriate social interactions, however we currently know very little about its neural basis. One possibility is that person knowledge is distributed in a network of modality-specific neural systems. Alternatively, Bruce & Young (1986) suggested a cognitive hierarchical model in which information from modality-specific recognition units (MRUs) is relayed to person identity nodes (PINs) containing or giving access to unified, amodal person representations. This project aims to advance our understanding of the neural mechanisms underlying person identity recognition. Specifically, using fMRI approaches with typical participants and individuals with selective developmental deficits, I plan to accomplish three objectives:(1) identify the neural regions that represent person identity information irrespective of input modality. Multivariate pattern analysis of neural activations to faces, voices and names of famous individuals will be performed to reveal areas that are sensitive to person identity per se;(2) reveal the content of identity representations in modality-specific and modality-independent regions. Using fMRI I will examine brain responses to famous, personally-familiar, and newly-learned individuals, from faces, voices and names. Within and across regions of interest and modalities, patterns of brain activation to different experimental conditions will be compared using representational similarity analysis (RSA) to reveal organization principles and representational content;(3) examine the development of PINs when MRUs are compromised. I plan to conduct a systematic behavioral investigation on identity recognition from various modalities in developmental prosopagnosics, individuals who have severe difficulties recognizing faces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrated Multimodal Airport Operations for Efficient Passenger Flow Management' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The airport of the future is expected to become a multimodal connection platform, creating the conditions for travellers to reach their destination by the most efficient and sustainable combination of modes and allowing the airport and its surrounding region to make a better use of their resources. The goal of IMHOTEP is to develop a concept of operations and a set of data analysis methods, predictive models and decision support tools that allow information sharing, common situational awareness and real-time collaborative decision-making between airports and ground transport stakeholders. The specific objectives of the project are the following:1. Propose a concept of operations for the extension of airport collaborative decision-making to ground transport stakeholders, including local transport authorities, traffic agencies, transport operators and mobility service providers.2. Develop new data collection, analysis and fusion methods able to provide a comprehensive view of the door-to-door passenger trajectory through the coherent integration of different types of high resolution passenger movement data collected from personal mobile devices and digital sensors.3. Develop predictive models and decision support tools able to anticipate the evolution of an airport’s passenger flows within the day of operations and assess the operational impact on both airport processes and the ground transport system, with the aim of enabling real-time collaborative decision-making between airports and ground transport stakeholders and enhanced passenger information services.4. Validate the proposed concept and the newly developed methods and tools through a set of case studies conducted in direct collaboration with airports, local transport authorities and transport operators. The case
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of NMDA receptors on experimental renal failure. Relationship with NO' (NMDANOARF), addressing dissemination and exploitation.

assistant: **Impact**

N-methyl-D-aspartate receptor (NMDA-R) is an amino acid receptor and membrane calcium channel. NMDA-R is activated by binding of co-agonists, L-glutamine and L-glycine. In the brain, calcium entry via NMDA-R activates type I nitric oxide synthase (NOS I).The kidney also contains NOS I and vasodilates in response to L-glycine. We recently demonstrated that NMDA-R are expressed in kidney cortex, where they exert a tonic vasodilatory influence and may account for the vasodilatory response to glycine infusion. Nitric oxide is a gas that exerts, among others, vasodilatory effects in the kidney.Me and others have demonstrated a role of nitric oxide in several types of acute renal failure, from aminoglicoside-induced, to ischemic in nature. Also, in a recent pap er, I suggested a role for nitric oxide in renal mass reduction due to uninephrectomy. Glycine infusion has been proven to be beneficial in several renal conditions, but the mechanism by which this happens is yet to be elucidated. From cyclosporine nephrotoxicity to ischemic renal failure, increases in glycine availability lead to improvements in renal function.Furthermore, use of NMDA antagonists has been proven to reduce ischemic damage in the brain and aminoglicoxide ototoxicity. Thus, the relationship between NMDA-R and NO in the kidney in normal and pathological conditions is an exciting field that could lead to new therapies in the treatment of renal diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Establishing continuous biomarker monitoring for Big Data in fitness and healthcare' (2014-2020).

assistant: **Innovation**

Goal of the PoC is to evaluate possible commercial applications of a multi-sensor test strip and the necessary oxygen scavenger that were patented within the ERC starting grant “REDOX SHIELDS”. Such a multi-analyte sensor can be used to calibrate the millions of data points generated by wearables every day to improve the accuracy of non-invasive sensors in a Big Data scheme in fitness and healthcare. The test strip is designed to accurately measure multiple analytes from a tiny drop of blood.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Distributed Learning-Based Control for Multi-Agent Systems' (DiLeBaCo).

assistant: **Innovation**

Multi-agent systems offer a great potential to improve the quality of modern society life. In the near future fleets of autonomous cars will be able to reduce traffic congestion and fuel consumption while increasing road safety. With almost half of all freight being transported by road, it makes up approximately a quarter of the total EU energy consumption and accounts for 18% of the greenhouse emissions. Fuel reduction in this area will have a significant impact on the environment. One way to achieve such reductions is through platooning where heavy-duty vehicles drive close to each other to reduce their aerodynamic drag and thus increase their fuel efficiency. While autonomous driving and platooning are areas of active research, open challenges arise in complex traffic scenarios with human interactions. Another challenge is that hierarchical control design with several different layers is required. The specific goals of the project are to develop novel algorithms for the control of safety-critical multi-agent systems in real-world scenarios, to understand the role of local informational constraints on the performance and safety of such systems and to design incentives for the individual agents that lead to a desired coordination of a fleet. This way global objectives will be optimized while accounting for complex traffic situations. The scientific contribution lies in combining  and extending recent results from distributed predictive control, statistical learning and game theory as well as understanding the role of informational constraints in distributed learning-based control of multi-agent systems. The developed methods will have a high impact on both industry and society. In particular, the project will enable platooning in more complex scenarios, which has the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role for the endogenous cannabinoid system in ethanol and nicotine addiction: implications for the treatment of drug abuse (CANNABINOID ALCOHOLISM)' (1998-2002) under Fifth Framework.

assistant: **Objectives**

This proposal is aimed to explore the role of the endogenous cannabinoid system (ECS) on the development of ethanol and nicotine tolerance, rewarding effects and physical dependence. The studies will be done in normal mice and rats as well as in CB1 knockout mice and Sardinian Alcohol Proffering rats. We will characterize the changes induced by acute or chronic ethanol/nicotine administration on the ECS, (Enzymes for synthesis and metabolism of endocannabinoids and cannabinoid CB1 receptors and its transudation systems), as well as the activity of drugs acting at the ECS in drug ethanol/nicotine self administration and withdrawal. The final goal is to investigate the utility of drugs targeting the ECS for the treatment of alcoholism and tobacco addiction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Open Collaborative Model for Tuberculosis Lead Optimisation'.

assistant: **Objectives**

Early stage Drug Discovery efforts over the last 5 years have resulted in the identification of a number of promising lead compounds in the fight against TB. These leads need to be further progressed and optimised into candidates for pre-clinical development through the Drug Development progression cascade.Three compound families are of particular interest: 1) InhA Inhibitors, 2) New potent whole cell anti-tubercular compounds with unknown mode of action and 3) new Beta-lactam/Beta-lactamase combinations for TB. A preclinical package is already in place for some of them, but further work is necessary for others in order to justify the progression of a single anti-tubercular family to the more resource intensive stages of preclinical and clinical development.The project will encompass the parallel progression of the three compound families through: A) Lead Optimization Chemistry efforts and MoA studies (Genetic and Proteomic) for whole cell inhibitors, B) In vitro and in vivo evaluation of a new orally bioavailable Beta-lactam alone or in combination with a Beta-lactamase inhibitor to evaluate the sterilising potential of the new drug/s and C) the optimization of an InhA inhibitor for later preclinical development.These efforts will yield candidate molecules for new ""information rich"" in vitro assays of antimycobacterial activity (artificial granuloma, activity against slow/non growing cells and activity against clinical isolates) as well as for in vivo safety and efficacy evaluation in different animal models of infection (acute and/or chronic). At this stage a single compound family will be prioritized.Further studies will be performed assessing the potential for shortening treatment in stand alone therapy as well as in combination regimens both in vitro and in vivo.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'NATURAL CAPITAL ACCOUNTANCY TO IMPROVE REPORTING AND ENVIRONMENTAL PERFORMANCE'.

assistant: **Concept**

Important investment decisions are more and more dependent on companies’ environmental performance and the quality of companies’ external environmental reporting. Thus, the biggest companies around the world disclose their sustainability performance to some degree and listed companies worldwide are increasingly aware of their impacts on the environment. There is a clear need of comprehensive tools to quantify the impacts of companies on natural capital and to help companies mitigate or compensate such impacts, so they keep up with the high environmental reporting standards. Existing solutions oriented to measure and reduce natural capital impacts neither provide an integrated measurement of the impact in terms of ecosystem services nor bring support to improve environmental performance. These tools are usually focused in single sectors and work only at narrow spatial scales (e.g. UK, European). In addition, any of them incorporates natural capital net loss and ecosystem degradation measures and its economic, hindering a more sustainable decision-making To bridge the gap between decision making levels around no-net-loss of natural capital, we, Creando Redes, have designed COUNTMITMENT: an online software that enables companies and public authorities to calculate and compensate the natural capital net debt that every industrial activity in any place can incur  COUNTMITMENT will have a deep impact in our company, as we estimate that it will yield a turnover of €7.12M, cumulated profits of €2.85M, 10 new direct jobs and a ROI of 2.01 three years after commercialization, reaching the payback during the second year.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Roles of Palmitoylation networks in ER architecture and functions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The endoplasmic reticulum (ER) is the largest intracellular organelle of mammalian cells. It fulfills major functions such as folding and quality control of membrane proteins, lipid biosynthesis, calcium storage, and modulation of apoptosis. This diversity of functions is accompanied by a complex 3D architecture, the maintenance of which is essential, since alterations lead to disease. How this architecture is generated, how proteins localize to specific subdomains and how structure and functions are coordinated is poorly understood. Our unpublished observations show that many ER membrane proteins, involved in key functions or in organelle shaping, are lipid modified, by the same palmitoyltransferases, and in a switch-like manner. We hypothesize that palmitoyltransferases act as regulators of the mammalian ER, controlling the function of a network of key proteins through reversible acylation, analogous to the control of signaling networks by phosphorylation. To establish the role of palmitoylation in coordinating ER structure/function, we propose a program integrating biochemical, functional and modeling approaches. We will determine the ER palmitome and investigate the impact of acylation on the function of individual proteins, on ER architecture and on the ER lipidome. We will analyze the interplay between and ubiquitination in controlling ER functions. Since we found that the DHHC6 palmitoytransferase is essential in mice and palmitoylates key ER proteins, we will study this enzyme in depth in terms of structure, function, target specific and regulation. Finally, we will combine the information emanating from these studies into a mathematical model of the ER palmitoylation network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Metamodelling of dynamic models of the heart', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Mathematical modelling of biological systems facilitates a deeper understanding of organ function and disease mechanisms. However, biophysically based models have a complex structure, are computationally demanding and extremely difficult to validate, and comparison of competing models is very challenging. These characteristics seriously delay progress in the use of modelling in sciences such as systems biology and medicine, and as the application of models to both large basic science data sets and in clinical context progresses these issues will become increasingly important. The aim of the proposed project is to reduce these bottlenecks using metamodelling, i.e. generation of statistical approximations of model input-output mappings. The objectives are to 1) reduce computational demand of multi-scale spatiotemporal heart models by substitution of parts of the models with statistical approximations, 2) establish a robust platform for global high-dimensional sensitivity analysis (analysis of the impact of the various input parameters on the model outputs) based on metamodels, enabling more efficient model validation, and 3) develop metamodel-based methodology for model construction and validation through systematic comparison and assessment of the prediction spaces of different models and comparison of models to experimental data. We will build a flexible metamodelling framework based on multivariate regression, adapted to handling the high parameter- and state space- dimensionality characterising multi-scale models. The fellowship will have a large impact on integration of metamodelling into the modelling community due to the central role that the host group has in e.g. the FP7-funded Virtual Physiological Human project. The methodology will be generic and highly instru
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Building an Excellency Network for Heightening Agricultural ecoNomic researCh and Education in Romania' (ENHANCE).

assistant: **Concept**

The project coordinator is among Romania’s most competitive agricultural universities, yet at international level and in the agricultural economics discipline still struggles to become fully competitive. Three extremely innovative and well-known Western institutions of agricultural economics research have agreed to deliver the necessary know-how to improve this situation. Mainly four important bricks have been designed in response to the call text of “Significantly strengthening a defined field of research in a particular knowledge institution by creating a link between this institution and internationally-leading research institutions”: 1. Institutional support is provided to implement internal review processes and to strengthen the motivation of the workforce 2. Quarterly training sessions on scientometrics, supply and demand analysis and modelling is going to support the scientific staff of the faculty to become more proficient in applying quantitative methods.3.  Summer schools will be held on game theory, full-cost-calculation and policy analysis in which students of the faculty, but also of other Romanian universities may train their handling of economic issues.4.  Three-months exchanges in both directions will stabilize the exchange of methods and theories and will provide opportunities for joint research and publication.Two groups will support the process: An International Advisory Board will evaluate the quality of the process from a scientific viewpoint after one year and at the end of the project. The Stakeholder Board has the objective of formulating local needs and to link them with the process of scientific development in the faculty. Intensive communication activities additionally contribute to inform the local and scientific public about the twinning pro