RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European School for Interdisciplinary Tinnitus Research' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The European School for interdisciplinary tinnitus research (ESIT) provides an opportunity for young researchers to work on leading-edge research projects, which will radically improve the situation of 42 million European tinnitus patients. They will develop new treatment solutions for tinnitus, fundamentally improve existing treatment paradigms, implement innovative research methods, perform the first genetic studies on tinnitus and establish the largest pan-European tinnitus dataset, which will allow the implementation of innovative solutions for personalized tinnitus treatment. High quality network-wide training will prepare the individual researchers with outstanding academic as well as personal skills to perform these tasks. The international training programme offered by the ESIT network extends far beyond the doctoral training that can be offered by single universities. A distinctive feature of ESIT is therefore the tight integration of academic, clinical, and industrial partners together with patient organisations and public health authorities. Fellows will be trained by leading specialists from multiple domains and become familiar with the various work environments in the European health sector. The strong intersectoral and interdisciplinary training provides them with all relevant skills and experiences to excel internationally, to recognise their full potential and to take mature career decisions. ESIT will thereby build up a future generation of creative, entrepreneurial and innovative researchers for the European Research Area, trained to master the upcoming challenges in the field, to implement sustained changes in the clinical management of tinnitus, and to shape PhD education programmes for forthcoming students.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multidimensional Analysis of Axis Patterning in Plant Embryo' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Plant cells are immobile, therefore positional signaling is essential for body patterning. While many genes involved in positional signaling in plants are known, we currently lack a mechanistic understanding of their functions. Embryonic axis pattering is the earliest and simplest instances of positional signaling. In Arabidopsis thaliana, embryo is initially radial symmetry. Soon after, the embryo switches to bilateral symmetry and development continues along the newly-established axis. How these patterns emerge from a small group of homogeneous cells remains a fundamental unanswered question in developmental biology. Answering this question requires an in-depth analysis of the spatio-temporal relationship between gene expression and cellular patterns. Today, advanced microscopy and latest image analysis allow us to quantify division, growth and gene expression in individual cells throughout embryogenesis. The host group has been studying the regulatory role of homeobox proteins, PHABULOSA (PHB) and PHAVOLUTA (PHV). Distribution of PHB/PHV protein is restricted by microRNA to apical embryo, triggering embryonic shoot formation. If the PHB/PHV distribution is a positional signal reflecting apical-basal axis, how do they regulate cellular growth and division patterns to establish axis? I will generate a 4D map of axis patterning, extract high quality quantitative data to develop spatial computer models, and examine the interplay between geometry and genetic regulation on axis patterning. I will also apply same approaches to study embryos in other Brassicaceae species. Such comparative developmental analysis will reveal the core mechanism of axis formation shared among these species and also provide insights into the origins of their embryonic morphological diversity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'An integrated approach to understanding the impact of de novo mutations on the mammalian genome'.

assistant: **Objectives**

Understanding the process of spontaneous mutation is fundamental for understanding the genetic basis of quantitative variation, the threat posed by declining population size in conservation biology and the distribution of nucleotide variation in the genome. I will address these and other unanswered questions concerning the evolutionary impact of spontaneous mutation using the house mouse as a model system. With the first, highly replicated mutation accumulation (MA) experiment in any vertebrate, I will study the impact of mutation accumulation on fitness and other quantitative traits and on genomic variation. I will pay particular attention to the effects of mutations in the heterozygous state, since this is important for resolving two important questions: 1. The threat posed by deleterious mutation accumulation in humans, where natural selection has weakened in many populations, and in endangered species, where declining effective population size has made selection less effective, and 2. The extent by which new mutations sustain response to artificial selection. By characterizing many thousands of mutation events by genome sequencing of MA lines and wild mice, I will determine the molecular spectrum and the factors explaining mutation rate variation across the genome. I will exploit this new knowledge to address the long-unanswered question of the causes of correlations between nucleotide diversity and the recombination rate and the density of conserved genomic elements. I will develop new approaches, incorporating the simultaneous action of mutation, selection, drift and recombination, to determine the contributions of background selection and selective sweeps to variation in nucleotide diversity, and to quantify the contributions of coding and noncoding mutations to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Selective Recovery of Critical Raw Materials by Using Metal-Organic Framework Based Adsorbents' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Selective recovery of Critical Raw Materials (CRMs) from underexploited mining side streams can contribute to reducing the European dependence on imports of these refractory metals. RUMBA: “Selective Recovery of CRMs (Nb, Ta, W) by Using MOFs Based Adsorbents” aims to improve the efficiency of conventional hydrometallurgical methods. These methods require the digestion of ores under strong acid or alkaline conditions and the recovery of CRM via liquid-liquid extraction. RUMBA innovative approach is based on the use of solid adsorbents known as Metal-Organic Frameworks (MOFs). MOFs are crystalline materials with porous and flexible frameworks. Their properties (porosity, flexibility, adsorption capacity, chemical and thermal stability) make them capable of extremely fast sorption with unprecedentedly high selectivity toward targeted ionic species. Despite their suitability for heavy metals capture, MOFs have never been used for recovering CRMs. RUMBA involves the first study of the interactions CRM-MOF to guide the design of frameworks with high affinity/selectivity toward target CRMs. Extraction experiments will be performed in samples from real mining streams. Additionally, the CRM-MOF systems will be studied for possible added-value applications of environmental relevance. The feasibility for succeeding in the scientific and training objectives pursued in RUMBA is supported by the strong expertise of the host institution (ICAMCyL) in advanced mining technologies and the solid background of the researcher in synthesis and characterization of MOFs. RUMBA offers the researcher the opportunity of resuming her research career through the exploration of a completely different application for materials she is familiar with. She will gain scientific skills in mineral processi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global Acoustic interaction and Psychoacoustic impact of the autonomous vehicles in interior and exterior NOISE' (2021-2027).

assistant: **Concept**

Future urban mobility is envisioned with electrified vehicles (xEV) with driving assistance systems (such as autonomous vehicles, AV) coexisting with other road users like pedestrians and cyclists, resulting in smart and sustainable cities with less air and noise pollution.However, one of the most significant problems with xEV in urban areas is the lack of noise. The noise reduction of vehicles has been very welcomed by society but with the inherent risk of losing its detectability, with particular attention to vulnerable road users. Several studies reported that xEVs are more likely to have more accidents with cyclists and run over pedestrians (especially the most vulnerable ones like blind people). External noise is one of the perils facing the quietness of xEV, but the interior noise should also be addressed. The internal acoustic and vibration environment would help reduce monotony and increase awareness of drivers using automated driving modes (with still required human feedback), and contribute to the passengers' welfare.In xEV running at low speeds (urban areas), most internal and external noises are produced by the electric and electronic elements in the powertrain. The electrified powertrain offers the opportunity to create specific sounds following certain requirements and endorsing associations for increasing safety in road users, awareness of drivers, and comfort appreciation.The GAP_NOISE project aims to define a set of actions to fill the gap between the current knowledge and technology in xEV and human psychoacoustics, combining the engineering fields of electric motors, modelling methods, control strategies, in addition to the recognized interaction between perceived sound quality and vibration. Thus, establishing an ideal theoretical and practical arena
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Clinical introduction of cellular extracorporeal hepatocyte support therapy in the treatment of chronic liver disease' in the context of a Fourth Framework call.

assistant: **Objectives**

Brief description : The concept of operation is to work on the basis of an established project, using already developed technology and device prototypes. Research or technological development is not required.The Project brings together the expertise of clinicians, bioengineers and cell biologists in a truly interdisciplinary approach. Four teams of researchers in four European countries are involved. Clinical applications within centers of excellence in the field of management of liver diseases are planned in order to gain clinical data for several concerted actions between university hospitals, to demonstrate the viability of a new field in medicine, and to interest European industry involved in medical devices and extra-corporeal therapies (dialysis, plasma separation, heart-lung support) with this new technology.Since the development is in the field of biomedicine and involves biotechnology, the traditional European companies handling with medical extra-corporeal devices have not yet decided to enter this field. The clinical trails in the Project are seen as a vital precursor to attract the interest of European companies with the necessary competencies and resources to carry hybrid liver support into industrial production and dissemination via larger scale clinical studies. Without the results of the Demonstration Project it is unlikely that such companies will be willing to commit substantial resources to the production of such systems. This would form the basis for industry-sponsored larger scale multi-centric European studies. A particular Project aim is to use company demonstration meetings as a tool to convince European industry that uncertainties and financial risks associated with this new field of medical technology are not as high as previously thought and t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Miniaturised Respiratory Assist to treat acute lung failure patients using a breakthrough hyperbaric technology' (MiRA) targeting Horizon Europe.

assistant: **Abstract**

Acute lung failure (ALF) is the third leading cause of death globally and is characterised by severe respiratory impairment. When non-invasive ventilation (NIV) fails, the treatment escalates to invasive mechanical ventilation (IMV) - the current standard of care for ALF. IMV is highly invasive, with a high risk of complications and an avg. in-hospital mortality rate of 35%, costing thousands of euros per patient. Hospitals have signalled an unmet need for safe and adequate alternatives to IMV in ALF. HBOX Therapies GmbH is bringing MiRA (Miniaturised Respiratory Assist) to market: a disruptive and innovative hyperoxygenation therapy that combines unrivalled blood oxygenation and CO2 removal to treat ALF patients, while they are awake. Such a breakthrough therapy has the potential to be the first treatment option for ALF patients who fail NIV. MiRA therapy has an outstanding cost-effectiveness and improved patient outcomes by avoiding or limiting the need for IMV and further respiratory deterioration in these patients. The growing incidence & prevalence of respiratory diseases causing ALF suggests that there are up to 6 million ALF patients who could benefit from MiRA every year, representing a market potential of €10.4 B/year. Behind MiRA, there is our extracorporeal hyperbaric blood oxygenation (HBOX) technology - 2 patents protect the technology and the approach. HBOX has been validated in animal trials (TRL 5) and we now need to: i) finalise the integrated system for improved safety & efficacy, ii) complete clinical studies, and iii) obtain MDR/CE certification for the MiRA medical device to commence commercialisation. We expect the results of the MiRA project to accelerate the market entry of HBOX and to serve as a platform technology for additional clinical applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'World Wide Welfare: high BRIGHTness semiconductor lasERs for gEneric Use' (2002-2006).

assistant: **Innovation**

High brightness laser diode technology is a key enabling technology for the modern information society, especially in the fields of health-care, telecommunications, infotainment, environment and security. Laser diodes offer high output power, compactness, robustness, and mass production capabilities. However their use in the above mentioned domains is often limited by the difficulty to reach satisfactory performances on  power and beam quality simultaneously. The term high brightness"  indicates exactly the capability  of a high power laser diode to provide high beam quality.The brightness governs directly the performance of systems, such as the transmission span of an optical data link, the reliability of a diagnosis in fluorescence imaging of cancer, or the resolution of a laser projection display. Therefore,  the need for high brightness laser diodes in these applications is currently strongly increasing.The WWW.BRIGHTER.EU consortium proposes a long-term vision aiming at pushing the limits of the current laser diode technology towards higher brightness, and at demonstrating applications such as:· Laser sources for medical imagery for cancer diagnosis and intelligent therapy· Optical amplifiers for telecommunication networks· Compact source for projection displayThe approach consists of mobilising the expertise of the core European players of the laser diode technology, and combining it with original optical technologies e.g. smart cavity concepts for higher efficiency and tunability. Leading European research centres and manufacturers participate in order to deploy the developed technology in new applications. Industrialisation constraints will be widely addressed through packaging and reliability studies. The consortium includes major companies and SMEs that will e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Impact of Magnetic field on Emergent solar spectra' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Solar brightness varies at all measured timescales and wavelengths, and canaffect terrestrial atmosphere and climate. Variations on timescales longer than a dayare driven by the solar surface magnetic activity. Solar magnetic field modifies thestructure of the solar atmosphere and its radiative properties, appearing at the surfaceas dark spots and bright faculae. These features continuously evolve with time andmodulate solar brightness. Although significant progress has been made in modelingsolar brightness variations, their amplitude in the ultraviolet (UV) range remainscontroversial. IMagE aims at resolving this controversy.A crucial ingredient of the irradiance models are brightness spectra of the variousmagnetic components. Spectra that have been used until now relied on a number ofsimplifications that are not valid in the UV. To properly account for the physicalmechanisms which influence the solar variability in the UV, including theline blanketing and departures from local thermodynamic equilibrium (LTE),non-LTE computations of spectra from realistic 3D magnetohydrodynamic (MHD)atmospheres are needed. This iscomputationally extremely challenging. IMagE will exploit state-of-the-art MHDand radiative transfer simulations to device a method for efficient, yet accurate,synthesis of the non-LTEbrightness spectra of the different magnetic components. This method will be validatedagainst high spatial resolution observations of the Sun. Incorporation of the spectracomputed with this method in the physics-based irradiance modelswill lead to a breakthrough in our understanding of the solar UV irradiance variability.The grid of non-LTE spectra for different magnetic field strengths and solardisc positions produced within IMagE can also be used to analyze the data fromfuture
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Assessment of an excimer laser based tool to achieve perfect dry single step resist and polymer stripping for submicron technology' (ELDS).

assistant: **Innovation**

To evaluate the L-Stripper system to obtain:Photoresist stripping results for the advanced processes of sub-micron technologies.Cost of ownership figures for reference to other equipment.Assessment of installation and equipment functionality for future improvements.Assessment of yield improvement.Removal of tough compounds which are formed during semiconductor wafer fabrication, is one of the tough challenges in photoresist stripping of sub half micron semiconductor wafers. The L-Stripper, a novel DUV-excimer laser based system, was developed by Oramir Ltd. to solve those demands. The fully automatic equipment comprises an industrial excimer laser, specially designed UV optics and a process chamber where the stripping process is achieved.The L-Stripper will be evaluated for its capability to achieve perfect dry single step (no post dry strip wet processing) resist and polymer stripping on deep sub-micron 150 mm and 200 mm semiconductor wafers.Expected results include single step dry photoresist stripping with reduction of cost of ownership (CoO), improved process yield and uptime.