RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Safe and COnnected aUtomation in road Transport' (SCOUT).

assistant: **Innovation**

The project ""Safe and COnnected aUtomation in road Transport"" (SCOUT) aims at identifying pathways for an accelerated proliferation of safe and connected high-degree automated driving in Europe, taking into account user needs and expectations, technical and non-technical gaps and risks, viable business models as well as international cooperation and competition.The analysis will start from a thorough consideration of the concerns and expectations from the perspectives of users, suppliers of the technology and experiences from projects and field tests. Alternative strategies for the implementation of automated driving will then be developed, under due consideration of different innovation cycles in the related industries (automotive, telecom, infrastructure, services) and the pending challenges regarding framework conditions (legal, testing & validation, safety & security).  With regard to the perceived use cases for connected automation in road transport, technical und non-technical gaps and risks for the implementation will be identified, assessed and ranked. In parallel, sustainable business models will be identified with particular emphasis on the role of digitization, connectivity and data-driven business cases. Advice for policies and regulatory frameworks for safe and connected automation will then be derived on the basis of the aforementioned analyses with the support of a network of relevant stakeholders, and subsumed into a common roadmap aiming to implement the formulated vision for ""Safe and connected automation in 2030"". The results will be communicated to and discussed with policymakers, stakeholders and the general public at a multitude of opportunities. International trends and results of European funded projects will be closely monitored and reflecte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Analysis of the gene regulatory network controlling ES cell identity' (GRNES).

assistant: **Concept**

Self-renewal of embryonic stem (ES) cells depends on the activity of a network of transcription factors at the centre of which lies the triumvirate of Nanog, Oct4 and Sox2 that bind together to a multitude of target genes to either activate or repress their expression. Nanog was initially isolated by the host laboratory on the basis that elevating its expression increased ES cell self-renewal efficiency. Surprisingly however, the host laboratory further demonstrated that ES cells continue to self-renew in the absence of Nanog, albeit with dramatically reduced efficiency. Moreover, Nanog is not expressed uniformly within the Oct4/Sox2-expressing undifferentiated population. Instead, ES cells fluctuate between a state in which Nanog protein levels are low or absent, associated with a poor self-renewal efficiency, and a state in which Nanog levels are high, associated with a high self-renewal efficiency. In order to shed light upon the means by which these fluctuations direct altered cellular functions, we propose a project with the specific aims of: (i) determining the gene expression profile in ES cells expressing distinct forms of Nanog, (ii) analysing the co-dependency of chromatin binding by Nanog, Oct4 and Sox2 at relevant target genes, and (iii) test the functional importance of the most relevant Nanog responsiveness genes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interconnection between R-loops and co-transcriptional alternative splicing' (RLOOP-AS) under Horizon 2020.

assistant: **Objectives**

R-loops are long RNA/DNA hybrids naturally formed behind RNA polymerase II (Pol II) during transcription, but their persistence is a threat for genome integrity through the creation of DNA damage, leading to cancer development. However, several recent studies reported a new and exciting role for R-loops in gene expression regulation by influencing transcription termination and chromatin modification. As mutations in several RNA processing factors have been shown to stabilize R-loop formation, we propose here to investigate the link between R-loops and co-transcriptional alternative splicing (AS) and to decipher the underlying mechanisms, a hypothesis supported by our preliminary results identifying more than 3000 splice junctions affected by decreased R-loops upon overexpression of RNase H1. The use of a specific antibody to RNA/DNA hybrids and stabilization/removal of R-loops coupled to high-throughput analysis of splicing (RNA-seq), R-loop profiling (DRIP-seq) and Pol II positioning and measurements (PRO-seq) will allow us to investigate genome-wide regulation of AS by R-loop formation. We will use particular AS events as models to elucidate the molecular mechanisms interconnecting R-loops and AS. Moreover, based on our previous expertise, we plan to study the impact of R-loops on DNA damage-induced AS alteration as a model of physiological regulation of AS by R-loops. This project will provide new insights on AS regulation through the formation of R-loops and also on cancer progression through R-loop stabilization. Finally, this project will allow me to acquire independent thinking and scientific leadership to reach an independent academic position in France.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Grammaticality and the minimal verb phrase: Evidence from colloquial registers' (MicroGram).

assistant: **Concept**

The main objective of this project is to explore in a systematic, data-driven and cross-linguistic fashion the morphosyntax of a recently discovered, unique clause type: radically truncated clauses (Halm 2021 ). Such clauses are radically minimal because, exceptionally, they are spelled out (i.e. uttered) at a very early stage of the derivation (i.e., sentence-building), prior to receiving almost all of the clausal layers that a sentence is supposed to have on top of the minimal verb phrase (VP) itself. In radically truncated clauses, layers oftense, agreement, mood, modality, aspect, voice and dedicated higher functional projections such focus or negation are missing: what remains is the minimal VP: the verb itself, its internal argument (an object or an unaccusative subject) and verbal particles (if they exist and are VP-internal in a given language). This minimal VP itself can be the target of adjunction (topicalization, quantifier raising and the adjunction of adverbial adjuncts) resulting in larger structures.Such truncated clauses have so far been neglected since they are only produced in specific, colloquial registers (live speech under intense time pressure, electronic communications), and such registers were difficult to observe and gather data on before the advent of widespread electronic text-based communication. My objective is i) to systematically collect and rigorously analyse a large amount of data on this construction from a set of typologically distinct languages and ii) to develop insightful theoretical conclusions from this large body of new empirical evidence.The theoretical questions where the study of radically truncated clauses is likely to be illuminating include linearization (or word order, more generally), case assignment, the exact size of no
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multi-Gigabit, Scalable & Energy Efficient on-board Digital Processors Employing Multi-core, Vertical, Embedded Opto-electronic Engines' in the context of a Seventh Framework call.

assistant: **Objectives**

New multi-beam Tera-scale capacity satellites will require a disruptive approach to address digital on-board processors that rely on electronics which consume space, power and cost and reach their capacity saturation. The disruptive solution must combine scalability, technical feasibility, power-efficiency and cost-effectiveness. ROBIN aims to provide this solution realizing multi-gigabit optical inter-connectivity with a unique combination of low-power and high-bandwidth multimode (MM) GaAs VCSEL/PDs, low power, radiation-hardened BiCMOS drivers and radiation-hardened multi-core fibers (MCFs). ROBIN will integrate these technologies on a space grade photonic integration capable to provide ruggedized transceiver modules with a record-high 150Gb/s throughput and 6mW/ Gb/s energy consumption which is a 3-fold improvement against state-of-the-art (SOTA) US-based products. ROBIN will fabricate the first >15GHz MCF-matched 850nm VCSELs operating at -40 to +100 oC and will drive energy consumption down to <200 fJ/bit (0.2 mW/Gb/s). ROBIN will demonstrate the first >30 GHz MM MCF-PDs with >0.6A/W responsivity. ROBIN will couple MCF-VCSELs/PDs to the first 6-core radiation-hard MM-MCF to offer the capability for single-feedthrough robust and hermetic module packaging. Fibers will be distributed through a monolithic fan-out avoiding the use and procurement of expensive connectors. ROBIN will develop the first 25 Gb/s 6-channel, driver/TIA ICs with record-low <2pJ/bit energy consumption in a 5-fold decrease against SOTA products. ICs will be fabricated with IHP 0.25μm SiGe BiCMOS process which is under ESA qualification. ROBIN will fabricate an opto-electronic 6x25 Gb/s capable ADC/DAC module using MCF optical interfaces and will test it in a full-scale optical interconnect bread
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Plasma-assisted catalysis for the removal of volatile organic compounds from waste gas stream' to be submitted under Sixth Framework.

assistant: **Abstract**

The purpose of this project is to investigate the effectiveness of the novel hybrid technology of plasma-assisted catalysis as a means for environmental clean-up of polluted, waste gaseous emissions and to gain a fundamental understanding of the synergistic effects that result from the combination of two existing and proven technologies. Particular emphasis will be placed on the destruction of emissions of volatile organic compounds including halogenated species.Attention will be given to minimising the production of unwanted and harmful by-products during the processing including the elimination of NOx (oxides of nitrogen) production when treating polluted air streams. A range of catalysts will be prepared and screened to maximise the efficiency of destruct ion and to exhibit selectivity in the minimisation of unwanted by-products. In this way, the goals of environmental clean-up will be achieved with minimum energy consumption.The efficiency of the processing will be enhanced by the incorporation of real-time computer control utilising artificial intelligence methods to obtain the required outcomes in terms of destruction and by-product formation in the most energy efficient manner possible. A fundamental understanding of the mechanism of the plasma-assisted catalytic processing will be achieved by producing a validated, computer-based, chemical kinetics-modelling package that will describe the gas-phase and surface chemistry.This will be used both to interpret the experimental results obtained and also as a predictive tool to allow new systems to be designed and developed. Collaboration with industrial partners will allow issues such as scale-up, implementation, field-testing and commercialisation to be addressed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Configuration and morphology of recycled polymers in life-time studies.' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The project aims at developing pyrolisis coupled with gas chromatography and mass spectrometry (Py-GC-MS) to monitor configurational changes in recycled polymers. These results will correlate with morphological changes determined by thermal analysis, improving the possibility to predict life-time of recycled materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Forecasting with large datasets: A time varying covariance matrix' (FORECASTING) targeting Horizon 2020.

assistant: **Abstract**

Recently there has been considerable focus on methods that enable time varying estimation of parameters in econometric models in the presence of, possibly stochastic, structural change. An interesting strand of this literature dispenses with the, computationally expensive and theoretically unclear, standard Bayesian estimation methods in favour of kernel estimation. In this project we intend to extend that strand of the literature to the case of large dimensional datasets and perhaps the most commonly explored problem of covariance estimation. Our primary focus will be to combine kernel estimation with fixed coefficient estimation methods for large dimensional covariance matrices. We will then try to provide theoretical results that allow for time variation in the large data generating process. This is a novel extension in the literature. To strengthen our theoretical results, we aim to provide an extensive Monte Carlo analysis and illustrate the utility of our methods in terms of out of sample forecasting. The proposed estimators have many interesting empirical applications. On top of the theoretical paper, our aim is to provide, two empirical papers, in the area of Macroeconomic Forecasting and Optimal portfolio allocation. To this end, we will use the proposed estimators, to forecast key macro variables with large dimensional linear regression, and compare with similar, data rich methods, that are currently used in the literature. Finally we will combine our methodological advancements with optimal portfolio allocation theories. Our preliminary empirical results show that the benefits from the proposed estimators are expected to be high and significant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Enhancing entrepreneurial ecosystems for education' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ENTREPRENEDU brings together different innovation stakeholders and educational entities from 6 different European countries, 3 low/moderate innovative regions (IT, BG, EL) and 3 high innovative regions (BE, DE, IE). The project aims at creating a high replicable and scalable education model (c.d. Venture Capital Program) for both businesses and educational systems via  a series of 3 Hackathons, developed at regional level, supporting developed concept and ideas to become concrete solution. At the end of the project, the program will be validated in the 3 educational entities that are part of the consortium. More specifically, ENTREPRENEDU aims at:• Enhancing the proliferation of new business model and entrepreneurial skills, directly involving 90 teams of youth (age 18 to 30 years old), in 3 different Hackathons (30 teams per Hackathons) ;• Providing a highly-replicable model to provide business know how for young Europeans, which will be validated in 3 educational institutions (IT, GR, BG) ;• Supporting the 12 most viable and promising ideas and concepts from the early stages to the commercialization of their solutions, through 5 concrete outcomes that should be reached by the end of the project (please refer to section 1.3) ;• Validating the Venture Capital Program (educational model) in 2 Universities and 1 VET entity on 90 students.The ENTREPRENEDU unique and interdisciplinary methodology will enhance entrepreneurial know-how and business skills and activities in less and moderate developed innovation regions, thus reinforcing their acceleration capacity and enabling youth to scale their concept to fully concrete solutions with strong market potential, subsequently enhancing the development and competitiveness of these regions.


**Keywords:** Venture Capital Progra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Morphogenesis during pre-implantation development: molecular and mechanical regulation'.

assistant: **Concept**

During the first days of mammalian development, blastomeres organize themselves into the blastocyst, which implants the embryo into the maternal uterus. Failure to build the blastocyst will result in a miscarriage and yet the mechanisms underlying the construction of the blastocyst are mostly unknown. The blastocyst is sculpted by forces generated by its constituent cells. Without a tool to study the mechanics of the mammalian embryo, it is challenging to identify the molecules and cellular processes controlling morphogenetic forces. Using biophysical methods, I have recently measured the forces shaping the mouse blastocyst and identified cellular processes generating and controlling them. This approach enables the identification of the molecules controlling morphogenesis and constitutes the first step towards a complete theoretical modelling of blastocyst morphogenesis.The aim of this project is to understand the molecular and mechanical aspects of blastocyst morphogenesis. By developing novel biophysical tools for the developing blastocyst, we will measure uncharacterized mechanical properties such as cytoplasmic and luminal pressure, adhesion strength and viscosity. The resulting mechanical map of the blastocyst will help understand the mechanisms of action of genes involved in its morphogenesis. To identify novel candidate genes involved in blastocyst morphogenesis, we will carry out a screen using live high-resolution confocal microscopy of mouse embryos injected with siRNA. Together, this will reveal the molecular, cellular and mechanical processes controlling blastocyst morphogenesis. I expect this to shed light on how blastomeres self-organize into the blastocyst and to reveal the physical laws underlying morphogenesis in general. Importantly, the knowledge and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biochemical and mechanochemical mechanisms in polarized cells' (BIOPOL).

assistant: **Innovation**

BIOPOL is an interdisciplinary European training network at the interface of cell biology, physics and engineering. BIOPOL aims specifically at the understanding of fundamental mechanochemical principles guiding cellular behaviour and function and their relevance to human disease. A new supra-disciplinary research field is emerging bringing together the fields of molecular cell biology, physics and engineering aiming at an in depth understanding of fundamental cellular mechanochemical principles. BIOPOL combines exactly this required expertise in one joint training program for young researchers. BIOPOL has assembled a unique multidisciplinary consortium bringing together top scientists from the fields of molecular/developmental cell biology, membrane physics, engineering as well as specialists from the private sector. The scientific objectives focus on understanding of fundamental mechanisms of cellular mechanosensing in health and disease, the role of external forces in cell division and mechanochemical regulation of cell polarity including tissue formation. Finally, part of BIOPOL´s research program is the further development of cutting edge technologies like advanced atomic force microscopy, novel photonic tools like optical stretcher or innovative organ on a chip technology, exploiting physical cellular properties. BIOPOL´s collaborative cutting edge research program is integral part of its training program provided to early stage researcher and is further translated into seven state of the art experimental training stations representing the consortiums expertise. In addition, BIOPOL has developed a 3 years modular curriculum including workshops, summerschools, Business plan competitions and conferences with a specific agenda of transferable skill training elements