RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Seaweed derived anti-inflammatory agents and antioxidants' (SWAFAX).

assistant: **Concept**

The project is designed to address a commercial opportunity to obtain bioactive compounds from seaweeds for application in food and health & wellness products. Although polyphenols from land plants are widely used as functional food ingredients and food supplements, seaweed sources have been little studied or exploited. The consortium comprises 4 SME partners Hebridean Seaweed, Marigot, Coressence and Mesosystem, and 3 RTD providers – CyberColloids and Universities of Reading and Ulster. In the first stage of the project seaweed polyphenol extracts (SPEs) will be prepared. One of the SPEs will be produced at food grade quality from Ascophyllum. In addition, a series of novel polyphenol extracts from a range of seaweed types of relevance to the partner SMEs, will be prepared. All the extracts will be characterised for their polyphenol content. The antioxidant and anti-inflammatory activities of the food grade SPE will be assessed in a dietary intervention trial in human subjects. The end points will include prevention of oxidative DNA damage in lymphocytes, and modulation of anti-inflammatory and pro-inflammatory cytokines in plasma. In addition a short-term dietary intervention in human volunteers will be conducted to assess bioavailability and metabolism of the component polyphenols in the extract. Finally the novel SPEs will be investigated for anti-inflammatory and anti oxidant activity in vitro. The food grade SPE will be included as a comparator. In this way it should be possible to extrapolate from the in vitro activities to provide an estimate of the likely in vivo effects in terms of anti-oxidant and anti-inflammatory properties and to provide the SME’s with candidate extracts with potential beneficial properties that can be further developed at a later stage. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intramembrane Proteases, their Inactive cognates, and Disease""' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The ability to release signals from the cell surface is dependent on the correct functioning of the secretory pathway. This proposal focuses on trafficking regulation and quality control within the secretory pathway by members of the rhomboid superfamily, and members of the Signal Peptide Peptidase-Like family (SPPL).The metalloprotease TACE (TNF alpha converting enzyme) is an important sheddase for cell surface proteins, including the proinflammatory cytokine TNF (tumour necrosis factor), and ligands of the epidermal growth factor receptor. Crucially, TACE activity is highly regulated by diverse physiological and pathological stimuli, but little is known about the mechanism of regulation.Recently I have shown that iRhoms, endoplasmic reticulum (ER)-localized catalytically inactive homologs of rhomboid proteases, are essential TACE regulators. iRhoms act as trafficking factors: they bind to TACE in the ER and control its trafficking into the Golgi apparatus, wherein TACE undergoes an essential activation step (prodomain removal). Because of this TACE activation defect, mice null for iRhom2 have profound inflammatory defects (caused by a failure to shed TNF). iRhom1 mice die a few weeks after birth because of a range of defects, whereas iRhom double knockout (DKO) mice, which completely lack TACE activity, die during mid embryogenesis. The fact that the DKO phenotype is worse than the TACE knockout implies the existence of novel clients.This program, which has a strong biomedical focus, will examine iRhom regulation in response to stimuli to address whether iRhoms are the illusive ‘sensors’ for TACE-activating stimuli. It will also identify novel clients implied by the severe iRhom DKO phenotype. Combining mouse knockouts, disease models and biochemistry, we will also ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Public attitudes towards Social Europe: Diverging interpretations and support within and across EU member states?', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Political leaders of the European Union increasingly believe that a ‘Social Europe’ is indispensable for the continuation of the European project. Even though the course towards a more Social Europe is set, it remains unclear what the notion of Social Europe actually means, as it can refer to very different policy objectives and instruments. This is a problem since citizens’ support is crucial to democratic decision-making but is also unclear amidst opinions about specific interpretations of Social Europe. That problem is compounded by the lack of scholarly attention to how different citizen interpretations of Social Europe interact and vary across EU member states. This project aims to redress this major scholarly silence, by theoretically and empirically exploring citizens’ attitudes towards various interpretations of Social Europe. Specifically, it aims to unveil (1) to what extent European citizens are concerned about the protection of existing social rights and their further development, (2) to what extent Europeans support the development of EU-level policies to protect and enhance social rights (rather than only relying on domestic social policies in the member states to do so), (3) which combinations of policy measures, reflecting different underlying notions of ‘Social Europe’, are most supported by European publics, and (4) what dividing lines exist regarding these supportive attitudes within and across EU member states. To this end, the project relies on a unique combination of four different large-scale opinion surveys. The empirical results will deepen understanding of the stumbling blocks to consolidating and improving the welfare state and the European Union and identify pathways to strengthen the EU’s social dimension in a way that is supported by Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Alpha CaMKII autophosphorylation as a mechanism to regulate alcohol consumption' (2007-2013).

assistant: **Innovation**

Understanding molecular basis of alcohol addiction still remains a great challenge for science and at the same time the only chance for designing successful molecular therapy. Calcium and calmoduline-dependent kinase II alpha (alpha CaMKII) is a major protein of forebrain glutamatergic neurons with well established function in various aspects of cell physiology, e.g. actin remodelling. Alcohol-induced actin remodelling has been recently implicated in control of alcohol resistance and consumption in mice. Interestingly, we have found that mice with mutated autophosphorylation domain (T286A) of alpha CaMKII (Giese et al., 1998) have decreased basal level of polymerized actin as well as alcohol consumption and preference (Radwanska, unpublished observations). Thus we would like to hypothesis that alpha CaMKII autophosphorylation is a key modulator of alcohol-induced actin-remodelling and thus alcohol consumption and preference. To verify our hypothesis we shell accomplish the following objectives: - to test whether autophosphorylation of alphaCaMKII regulates acute behavioural response to alcohol as well as to long-term alcohol drinking; - to identify brain regions in which autophosphorylation of alphaCaMKII contributes to actin remodelling; - to investigate which signalling pathways connect CaMKII autophosphorylation in mutant mice with actin remodelling; - to test whether autophosphorylation of alphaCaMKII regulates actin remodelling induced by alcohol; Here we will establish the role of CaMKII autophosphorylation in actin remodelling and alcohol preference. Toward this end, integrative approach will be used: behavioural studies with mutant mice (CaMKIIT286A) will be combined with various molecular and biochemical analyses of protein expression and phosphorylation. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Degassing systematics of Highly Siderophile Elements from magmas: New constrains on the convecting mantle, and the origins of global HSE anomalies in sedimentary rocks' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Highly Siderophile Element (HSE: Os, Ir, Ru, Rh, Pt, Pd, Au & Re) studies in oceanic basalts provide vital information on the partial melting regime, constrains on the different mantle end-member compositions, and hence on mantle geodynamics. However, it has been recently showed that Re could be lost by volatilisation upon eruption of the basalts. For the other HSE, the only evidence (indirect) of their potential losses via degassing resides in the high Ir and Au contents of volcanic emissions and airborne particles.This project aims to obtain quantitative constrains on the volatile loss of HSE during magma degassing in order to better constrain the mantle composition, the degassing flux of HSE to atmosphere and determine whether global HSE anomalies in the sedimentary record result from meteorite impacts or large-scale volcanic emissions. These objectives will be achieved by coupling studies of HSE and volatile elements in oceanic basalts from the Lau Basin, Iceland and the East Pacific Rise. Analyses o f melt inclusions and basalt glasses will provide the pre-eruptive and post-eruptive composition of the lavas.HSE will be determined by ultra-sensitive inductively coupled plasma mass spectrometry (ICP-MS) after ultra-low blank separation techniques. Volatile elements (CO2, H2O, d13C and d18O) will be analysed using a volatile extraction line coupled with ICP-MS, secondary ion mass spectrometry and Fourier transform Infra-Red Spectroscopy. This project will promote research excellence and the innovative and multidisciplinary aspect of European research by undertaking the first study ever done on the effects of degassing on HSE systematics.The development of new, ultra-low blank HSE separation coupled with for the first time micro-drilling techniques applied to the analy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Strategic Assessment Methodology for the Interaction of CTP Instrument' under Fourth Framework.

assistant: **Concept**

The overall goal for Project SAMI, as specified in Task 1.6/33, is:i) to define a comprehensive assessment methodology;ii) to describe major findings and policy recommendations on CTP issues including policy implementation in the CEEC/CIS;iii) to define and develop decision models (presented in a report and an interactive computer program) which can be used in relation to the interactions between policy instruments/measures and identified CTP targets;iv) to prepare a short manual/guide for strategic policy assessment on CTP issues, addressing the policy and decision-makers.Within the overall goal, the following specific, measurable objectives have been specified, each related to a work package, each directly measurable, and each contributing to one or more of the project deliverables: 1) to identify candidate CTP targets and assess possible conflicts and synergies between them in order to define the structure of a target system including hierarchical levels, interactions, and quantifiable indicators;2) to define scenarios and sets of possible CTP instruments related to selected targets;3) to refine and test an optimisation methodology - previously developed on an urban level - on the European strategic level;4) to define and develop a strategic assessment methodology - including necessary software - for system-wide (European) impacts of policy packages; 5) to clarify the conditions for CTP implementation on the European level when considering also the implications in the CEEC/CIS.Links with other projects, tasks, areas, programmes, policy actions:Definition of the scenarios: projects SCENARIOS (tasks 1.1.2/11A, 12 A, 13), STREAMS (1.1.2/11A, 12 A), POSSUM (1.1.2/13).Instruments: projects QUITS (task 1.2/14), TRENEN II STRAN, PETS, ECONOMETRIST, EUROTOLL (all four in tas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Quantum Waveguides Application and Development'.

assistant: **Innovation**

Quantum technologies promise to revolutionise our digital world providing security in communications and solutions for what have been thought of as unsolvable computational problems. The project QWAD introduces the technology of laser-written integrated optics, a powerful new tool for next generation quantum communications and computing, solving critical problems in terms of scalability and reliability. This disruptive photonic technology will speed up the evolution from lab systems to real world applications.<br/>Our consortium will target three main outcomes:1) Fabricate laser-written waveguides in highly integrated three dimensional structures to generate and to manipulate both path- and polarization entangled photonic qubits.2) Implement large integrated circuits to perform scalable quantum logic operations and quantum simulation of many-body dynamics.3) Design dedicated waveguide structures for fully integrated quantum key exchange and for quantum enhanced sensing in application ready prototypes.<br/>The project benefits from the outstanding expertise of consortium members who have pioneered photonic and quantum information technologies over the past decades. The development of laser-written waveguide structures will allow extraordinary progress in terms of miniaturization and scalability while maintaining incomparable stability and durability. Key advances in quantum ICT will exploit the 3D waveguide geometries and other innovations to produce tailored quantum simulators and photonic quantum computer nodes. The development of novel ready-made quantum devices within QWAD will open new doors for innovative chip based quantum key exchange components and unrivalled efficiency and sensitivity Lab-on-a-chip devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'InDeV: In-Depth understanding of accident causation for Vulnerable road users'.

assistant: **Innovation**

The InDeV project addresses the second bullet point of the topic MG.3.4. i.e. “… in-depth understanding of road accident causation…”. The main objective of the project is to develop a tool-box for in-depth analysis of accident causation for Vulnerable Road Users (VRU) based on a combined use of accident databases, in-depth accident investigations, surrogate safety indicators, self-reported accidents and naturalistic behavioural data. The tool-box will help to link accident causation factors to VRUs’ accident risk, and provide a solid basis for developing preventive countermeasures and a better input for socio-economic cost calculations of VRU accidents. The proposed approach is to reveal the causational factors by focusing on the process of accident development, thus overcoming the main weakness of the traditional accident data based approach that might find correlations between various factors and accident frequency, but not show the causation chains. It will also employ, to a larger extent, observation of critical traffic events that are similar in process to real accidents, but are relatively more frequent and easier to collect in sufficient quantities. The InDeV project includes the following steps: i) review of methods and identification of the critical sites and road user groups; ii) observation studies at the selected sites; iii) development of technical tools for automated behaviour data collection; iv) analysis of the socio-economical costs; v) compilation of the project results and development of the safety analyst tool-box. The project has a clear focus on VRUs and the course of events in accidents they get injured in. It will provide solid knowledge, help to avoid a skewed view on the problem of VRUs’ safety, and facilitate the proposed tailor-made counterme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development and application of a computable model of general equilibrium to analyse the contribution of halieutic activities to regional development' (PECHDEV) under Fifth Framework.

assistant: **Objectives**

The principal objective of this project is to develop new tools and Models to assess the contribution of fisheries and aquaculture activities to the development of coastal areas, and the degree of interrelationships which maritime activities maintain with components of other economic sectors in the same area. The exercise has a wider scope in that it can facilitate the decision process at the level of public policy makers and the firm. It will provide tools and models as decision-making aids (in particular with respect to decisions concerning the new objective 2 and any structural measures for the fisheries sector).The program is organised in 6 work modules, each sanctioned by the delivery of a product marking a step in the model development to evaluate the contribution of aquaculture and fisheries to coastal area development and their interaction with other sectors of the regional economy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Promoting SMART agricultural WATER management in Bosnia and Herzegovina'.

assistant: **Objectives**

The main objectives of SMARTWATER are: 1) to reinforce the networking, research and innovation capacities of the University of Banja Luka (UNI-BL), University of Sarajevo (UNSA) and other institutions from Bosnia and Herzegovina in the field of sustainable agricultural water management; and 2) to increase their competences and fund-rising skills for a successful participation in the EU Research and Innovation Programs. The project will develop a large set of joint activities promoting networking, joint experimental fields, research cooperation and the exchange of knowledge and experts on specific topics, which are compatible with the overall national research strategy and include the application of smart technologies (cloud-based and remote sensing) in agricultural water management, optimization of water-energy-food nexus and climate change impact and adaptation measures. SMARTWATER foresees the publication of joint research documents in international conferences and peer-reviewed journals. The project will provide technical assistance and expertise to improve research and innovation capacities of BH institutions and delineate adequate national research strategies and policies for the future. The project will boost the S&T capacity through a series of capacity building actions focusing mainly on the early stage researchers. These include advanced training courses, participation in a joint MSc program, summer schools and hands-on workshops on R&I funding. A modern scientific strategy for stepping up and stimulating scientific excellence and innovation capacity will be outlined following a multi-stakeholder participatory approach. An effective communication and dissemination strategy for the adequate promotion of twinning activities and ensuring the expected impacts at re