RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Contribution of the Epstein-Barr Virus and the Tumour Microenvironment to Anti-Apoptotic Mechanisms in DLBCL'.

assistant: **Innovation**

Diffuse large B-cell lymphoma (DLBCL) accounts for over one-third of lymphomas and is fatal in up to 40% of cases. Particularly poor survival is associated with DLBCL subtypes that over-express the oncogene MYC and contain the cancer-causing Epstein-Barr virus (EBV). These tumours frequently resist apoptosis, with a poorer response to chemotherapy. Recent evidence has strongly implicated a role for the tumour microenvironment (TME) in cancer progression; however, the relationship between EBV, MYC, and the TME in DLBCL remains poorly understood.CoMAnD aims to elucidate the synergistic relationship between EBV, MYC and the TME to explore how these oncogenic drivers converge to protect DLBCL tumours from apoptosis. This will be achieved using a new generation of EBV+ and EBV- DLBCL models to derive novel insights into the biology of EBV+ DLBCL. This will be coupled with state-of-the-art intravital imaging of tumour progression in humanised mice and highly multiplexed, spatially resolved, imaging of the TME in EBV+/- patient tumours. This will allow the study, in unprecedented detail, of the impact of viral and cellular oncogenic drivers on the TME and apoptosis in DLBCL.This research directly contributes to Cancer- and Infectious disease-related EU and UN goals, and will support the areas of Open Science, Gender Equality, and the Green Charter.The Fellow will spend 2 years at the Walter and Elisa Hall Institute of Medical Research (Australia) expanding her skills in in vitro disease mimetics, and acquiring a skillset in apoptotic pathways and intravital imaging. She will return to the University of Limerick (Ireland) and receive training in high-dimensional imaging and data analytics.The Fellow will be immersed within a multidisciplinary team with expertise in lymphomagene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optimal Transport and Metric Structures for Evolution Problems' (OPTiMiSE) under Horizon Europe.

assistant: **Objectives**

Several evolution problems, such as gradient flows or rate-independent processes, are governed by variational principles which are extremely useful for studying the existence, stability, and structural properties of solutions by simple and general constructive approximation methods.Deep and beautiful ideas from the theory of Optimal Transport have contributed new insights and additional challenging questions to this scenario and have motivated flourishing and original developments. On the one hand, the applications to gradient flows in the Kantorovich-Wasserstein spaces of probability measures reveal the importance, the power, and the flexibility of the metric viewpoint. On the other hand, the interplay with evolutionary problems has in turn brought new ideas and perspectives to Optimal Transport, inspiring a powerful set of techniques for its applications, especially to the analysis and geometry in metric-measure spaces.In recent years, the PI and his collaborators have given relevant contributions to the general theory of gradient flows, in particular in Kantorovich-Wasserstein spaces, and they have obtained ground-breaking results for metric-measure spaces and Unbalanced Optimal Transport between positive measures with finite mass.The goal of the project is a wide-ranging analysis which aims to combine and broaden the above themes and perspectives, to address crucial and challenging open problems, and to open up novel research directions:  - new generation results and metric-variational principles for evolution equations,- the interplay between curvature bounds and convergence of variational approximation schemes,- a new metric approach to dissipative evolution and saddle-point flows,- new methods and results for paradigmatic highly nonlinear and non-convex partial d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'THE FIRST PERCUTANEOUSLY IMPLANTABLE PADDLE LEAD FOR SPINAL CORD STIMULATION', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Worldwide, around 1.5 Billion people suffer from chronic pain. Chronic pain undermines the ability to lead a productive working and social life, and it has significant impacts on the private and public economy. The estimated total cost for chronic pain is calculated to reach yearly as much as €455 Billion in the USA, and €300 Billion in Europe. Spinal Cord Stimulation (SCS) is a pain relief technique that consist in delivering current pulses to the spinal cord in order to block the sensation of pain. Basic SCS devices comprise implantable leads that are connected to a pulse generator controlled by a control unit. The leads currently available in the market are rather bulky and rigid, poorly stretchable and usually their implantation requires a complex chirurgical intervention.The Percutaneous Spinal Cord Stimulation Paddle Lead (SCS ExpertTM) proposed by WISE is a foldable lead fit for minimally invasive percutaneous implantation, which can be achieved by neurosurgeons and anesthetists. This innovative product addresses a key market need within the SCS segment of the growing neuromodulation market. The goal of this project (PercPad) is to complete the development of SCS ExpertTM and to prepare the path to introduce it into market by the Q4 2022. PercPad is a solid project that will generate important benefits for our company. Within a 5-year period after the launch, WISE expects cummulative gross profits of €36.2 Million, with a payback period of less than 5 years.We have identified a promising market opportunity, as the global neuromodulation market is projected to attain a value of €6.5 Billion in 2022 by rising at a CAGR of 12.5% from 2017, and our target segment is expected to cover over 1/2 of such market worth. Altogether, this represents a very promising scenario
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'De novo Synthesis of Fluoroarenes and Fluoro(hetero)arenes' (FARAON) targeting Horizon Europe.

assistant: **Abstract**

Historically, one of the biggest challenges in synthetic organic chemistry has always been to synthesize fluoroarenes (Ar-F) and fluoroheteroarenes (Het-F) from cheap, readily available starting materials, as fluorination has always concerned synthetic chemists due to either undesirable safety of reagents, low selectivities or poor reactivities. Since fluoroaryl- (Ar-F) and fluoroheteroaryl- (Het-F) are the most common fluorinated motives among pharmaceuticals development of a completely novel synthetic strategy would be of great importance to the research community. De novo construction of fluorobenzene using C1F1 synthons is an unprecedented process. We foresee that little explored monofluorinated ortoformates (RO)3CF (FOFs) could be a synthetic equivalent to access C1F1 synthon for annulation reactions.


**Keywords:** Fluoro-ortoformates (RO)3CF (FOFs), De novo synthesis, C1F1 synthon, Fluoroarenes, Fluoro(hetero)arenes, Annulation reaction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Chemist Researcher for Adhesive and Resolvable Electrolyte Gel Development'.

assistant: **Innovation**

Chemist Researcher for Adhesive and Resolvable Electrolyte Gel Development EEG is a well-established clinical diagnostic method and a valuable tool in neurocognitive research. Lately it is becoming increasingly important for applications like Brain-Computer-Interfaces, NeuroErgonomics, NeuroMarketing. These usages would be even more effective, if EEG would not be so delicate. A lot of working time is wasted in the established applications, and the development of the newer applications is heavily impaired by electrodes that fall off or lose contact, and by incomprehensive EEG data due to overlaying movement artifacts. This situation could be cured very often by electrodes that are fixed to head or skin in an absolutely reliable way, in order to fully benefit of the EEG’s property to be a non-invasive, uncomplicated method to register brain activity as the basis of everybody’s behavior. Our plan is to develop such a reliable fixation method with chemical methods. We, Easycap GmbH, are experienced in manufacturing EEG electrodes and accessories for many different applications, including a high level of support, and therefore we can make sure, that a new product for this field will be user-centered and exactly fitting, and we have the structure for subsequent certification, marketing, and sales to a widespread community. But we currently lack of chemical knowledge, and therefore we are applying for a doctoral chemist as innovation associate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'User-centric Middleware Architecture for Advanced Service Provisioning in Future Networks' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The current paradigm in service provisioning to future communication networks lacks thorough end-to-end interpretation from the quality viewpoint, while the end-users’/customers’ profiles and preferences are mostly not taken into account. The subjective perception of a provided service, known as Quality of Experience (QoE), is one of the most important factors for a user’s decision on retaining the service or giving it up, and the key parameter for enabling advanced customer experience management (CEM). The main objective of CASPER is to combine academic and industrial forces towards leveraging the expected benefits of QoE exploitation in future networks.  In particular, CASPER will exploit the most recent approaches in communication networks, such as the Software Defined Networking (SDN) and the Network Functions Virtualisation (NFV), to design and implement a middleware architecture for QoE-driven service provisioning. The architecture will consist of three interlinked modules, one-to-one mapped to the three instrumental functionalities required for the beneficial exploitation of QoE: i) reliable, secure and passive QoE monitoring, ii) efficient, dynamic and objective QoE estimation, and iii) robust and real-time QoE-driven service management. The three modules will be optimised and released as an integrated solution, in order to accelerate the adoption of QoE-driven network service management. The cornerstone of this effort will be a carefully-planned inter-sectorial secondment programme for Experienced Researchers (ERs) and Early Stage Researchers (ESRs). Under this programme, CASPER is expected to foster the exchange of knowledge and strengthen the collaboration among academia and industry through a bidirectional knowledge-sharing approach, where the academic benef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Directed Evolution in Microdroplets' under Seventh Framework.

assistant: **Concept**

Directed evolution of functional proteins has arguably emerged as an approach to protein engineering that can complement or better design-led approaches to protein function. However, as a random process, enormous numbers of variants have to be screened and selected to have a chance to identify successful catalysts. This process is costly and cumbersome: Industrial screening facilities require investment of tens to hundred of millions of dollars.In the context of ERC StG “ChemBioMech” key steps towards conducting quantitative biological experiments in a much cheaper format (with higher throughput) have been made. Screening of individual library members in monodisperse oil-in-water compartments ('microdroplets’) that are generated in microfluidic devices has been shown to be possible. The droplet compartment constitutes a link between a given phenotype and its encoding genotype. By capturing reaction product the droplet provides a unique system to screen for catalysis.This application is to exploit the commercial potential of a screening system of unprecedented capacity for directed evolution of enzymes that will be attractive for the biotech industry. To implement proof-of principle experiments we have teamed up with two leading industrial partners, to develop and validate the technology by implementing droplet-based selections for relevant industrial problem.Based on interactions with Cambridge Enterprise (the technology transfer office of Cambridge University) that have led to the filing of one patent, we continue to explore the IP landscape, expand ongoing interaction with potential licensees and conduct a marketing study. Finally we will develop a training module to facilitate uptake of this technology in different settings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'European network of excellence in computational logic, Compulog net iii' in the context of a Fourth Framework call.

assistant: **Objectives**

The aim of the network is to support all phases of technological change associated with the research, development and application of logic-based techniques and methods in all areas of computing.The research fields of Compulog Net encompass every aspect of computational logic, though special emphasis is currently placed on: Knowledge Representation and Reasoning; Concurrent and Constraint Logic Programming; Logic-Based Databases; Program Development; Language Design, Semantics and Verification Methods; Implementation Technology and Parallelism; Automated Deduction Systems; (Computational Logic and) Machine Learning; (Computational Logic and) Natural Language Processing; Spatial and Temporal Reasoning.Logic-based approaches to computing have a vast potential for industrial exploitation and are currently applied in such diverse sectors as manufacturing, engineering, transportation, distribution, telecommunications, banking, finance, insurance, data management and medicine, as witnessed by numerous case-studies presented at the network's industrial seminars, at network sponsored conferences such as the Practical Applications of Prolog (PAP), the Practical Applications of Constraint Technology (PACT), as well as at the Japanese Symposium and Exhibition on Industrial Applications of Prolog (INAP).The network is structured into three distinct but interrelated frameworks: - Research Co-ordination;- Industrial Action;- Education and Training;together with a fourth framework supporting each of the others: - Information and Infrastructure.- Research Co-ordination is supported by the activities of Research Area Coordinators for each of the Areas mentioned above. These include the organisation of technical meetings and workshops, support for related events and conferences, and infor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Innovative slate splitting machinery' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The manufacture of roofing slates requires the extraction of large slate blocks from a favourable deposit. These blocks are cut into rectangular, 12 cm thick parallelepipeds (called repartons ) whose dimensions are slightly superior to the slate that is going to be manufactured. These repartons are then split into fendis along the plane of cleavage of the slate; this is the splitting operation, which is followed by the edge dressing operation whose purpose is to produce a slate with definitive dimensions, rustic looking bevelled edges which give an attractive aspect to the slates, when they are laid on a roof. These operations generate a lot of waste (only 4 tons of slates are produced for 100 tons of broken down rock) and have remained very manual: the labour expenses represent 80% of the total expenses of a factory). Europe will not be able to preserve a long time its slate industry without rapidly correcting these two weak points. This research project aims at developing a new machine to split the slaty rocks. This new machine will make it possible to exploit the slate contained in the small slate blocks that are now left in the waste heaps of the quarries because their transformation into finished products is no longer profitable. In addition to the reduction of the volume of the slate waste and of the environmental nuisances, the project mainly aims at strengthening the competitivity of the European slate industries, threatened by the competition from countries with a low labour cost. Such a project is based on a major innovation: splitting the small blocks with a jet of water under a 2500 bar pressure whereas slate blocks are presently split with compressed air or manually in countries where labour is cheap. Water splitting is close to the gestures of the old time
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Control of cbp histone acetyl-transferase activity during the cell cycle' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

I will get familiar with the field of chromatin structure and learn new techniques related to this domain. Of special interest for me are acetylation assays for proteins and peptides, handling of high molecular weight protein complexes and the recently developed technique of chromatin immune precipitation. The theoretical as well as the technical knowledge base in the area of chromatin structure and its influence on gene regulation are highly developed in the host laboratory. This environment will allow me to participate in the elucidation of the molecular aspects of cell cycle regulation and cancer development. Knowledge of theRB/E2F pathway and of cell cycle control that I obtained during my PhD will be helpful to conduct the project. For the host laboratory evaluation of the function of CBP/p300 in the control of cell proliferation and tumour suppression is an important issue which could lead to new concepts in cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Soviet Union and Israel in the Global Cold War: Antisemitism, Anti-Zionism, and the Ideology of Soviet Foreign Policy (1967-1991)' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

SOVILASAZION is an interdisciplinary historical project dedicated to studying Soviet anti-Zionism as an element of Soviet foreign policy’s ideology. Using previously unavailable recently declassified archival sources, the project will be set out to analyze the interconnections of Soviet anti-Zionism with the practices of Soviet foreign policymaking in the circumstances of the Global Cold War and will discuss them in relation to the domestic antisemitic discriminatory practices in the USSR. By doing so, SOVILASAZION will broaden our understanding of the ideological legacy left from the Cold War era for our times, when the discussion about the difference between antisemitism and the permitted criticism of Zionism is even hotter than 40-60 years ago. Addressing Soviet anti-Zionism as an element of Soviet foreign policy’s ideology, SOVILASAZION will investigate the history of the post-1967 relations between the USSR and Israel. It will address the attempts of the more pragmatically oriented wing of Soviet bureaucracy to lobby the restoration of the official diplomatic relations that had been broken off after the 1967 Six-Day War and study how the ideological limitations prevented such restoration. SOVILASAZION will also address the functioning of the Soviet bureaucracy in the sphere of foreign policy, it will highlight the heterogeneity of Soviet bureaucratic apparatus and, overall, will broaden our understanding of this underresearched part of the Cold War history.


**Keywords:** Soviet Union,  Ideology,  Cold War,  Antisemitism,  Anti-Zionism,  Israel,  Foreign Policy