RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mitochondrial crosstalk signalling in the regulation of ageing' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Mitochondrial defects are associated with aging and age-related pathology, but the molecular mechanisms regulating mitochondrial function during ageing are poorly understood. The most relevant genetic pathway regulating ageing is the insulin/IGF-1 signalling (IIS) pathway. The mitochondrial prohibitin (PHB) complex influences cellular metabolism and mitochondrial biogenesis, affecting ageing in opposite ways in wild-type animals and IIS-defective C. elegans mutants. The aim of the proposed research programme is to shed light on the intricate communication between mitochondria and cell-signalling networks in the regulation of ageing. Our specific objectives are: 1-Elucidate the cellular signalling pathways involved in the metabolic responses to mitochondrial dysfunction upon PHB depletion in wild type animals and IIS-defective mutants, using genome-wide RNAi screens, 2-Conduct a comprehensive metabolic profiling of wild type and IIS mutants in the presence and absence of prohibitins and 3-Identify genetic suppressors of prohibitins by performing forward genetic suppressor screens. As an ultimate goal, genes discovered in C. elegans will be tested in vertebrate assays for a conserved role in ageing. We will implement an interdisciplinary approach that combines the genetic power of C. elegans with state-of-the-art metabolomic approaches as well as automated sorting and optical imaging technologies to monitor fat content and mitochondrial biogenesis, in a genome-wide scale, in vivo. The fine-tuning of cellular metabolism, by integration of diverse signalling inputs is the molecular basis of longevity. This project represents a truly integrative and innovative approach to identify cellular signalling pathways involved in mediating lifespan-extending metabolism adjustments, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Latin Talmud and its Influence on Christian-Jewish Polemic' under Seventh Framework.

assistant: **Concept**

While polemics and dialogue between Judaism and Christianity are as old as the Christian religion itself, one can clearly distinguish different periods, trends and intensities in the relations between the faiths. A significant landmark in this long and complex history is the Latin translation of large sections of the Talmud, the most important Jewish post-biblical text and the basis for the development of Rabbinic Judaism.When during the 13th century Christian theologians started to examine and translate the Talmud from Hebrew and Aramaic into Latin, they were faced with a huge body of texts which represented centuries of legalistic and homiletic materials. The discovery of this immense post-biblical Jewish literature became a source of fascination for Christians who believed that this text, which encompasses every aspect of Jewish life, was fundamental both for refuting the Jewish faith and for substantiating the truth of Christianity. This realization heralded a rethinking of the place of Jews in Christian society and redefined Christian-Jewish dialogue and polemic.The purpose of our project is to edit and publish the largest extant collection of Talmudic passages translated from Hebrew into Latin, that is, the ""Extractiones de Talmud"", while studying this ground-breaking document in the context of the trial and burning of the Talmud in 1240-42 and its aftermath.This project addresses vital questions of Jewish and Christian identity, still relevant to the 21st century, and can only be carried out by a transdisciplinary research team including specialists from Latin Philology, Hebrew Studies and History.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unraveling how evidence accumulation determines conscious experience using voltammetry' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Consciousness entails the phenomenal experience we have of the world and ourselves. Although it is at the heart of major philosophical, scientific and ethical issues, our understanding of the neural mechanisms of consciousness remains limited. The study of consciousness is compartmentalised, with researchers focusing on isolated sub-aspects of the problem, via restrictive paradigms that ignore the temporal dynamics of conscious experience, its metacognitive component, or its dependence on levels of consciousness. Moreover, we know virtually nothing about the single-neuron and neurochemical basis for consciousness in humans.VOLTA will advance beyond these empirical and theoretical limitations by conducting a multidimensional and multiscale study of consciousness. The project builds on a computational framework I recently developed linking consciousness to evidence accumulation. It will utilise the clinical context of pharmaco-resistant epilepsy to collect unprecedented behavioural and neural data. Individuals with epilepsy will participate in novel behavioural paradigms quantifying multiple dimensions of conscious experience, including its temporal dynamics, metacognitive components, and existence under sleep and anaesthesia. These experiments will be combined with triple neural recordings that simultaneously characterise #1 the global activity of neural populations, #2 spiking activity of individual neurons, and #3 electrochemical activity by measuring neuromodulator release with voltammetry. These unprecedented recordings will provide a multiscale map of the neurobiological basis of consciousness. My team and I, assisted by international experts, will interpret this rich dataset in light of seven preregistered hypotheses derived from my computational framework. In summ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Larpocracy: Developing Spaces for Deliberation and Democratic Skills through Role-Playing', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Online social media is not living up to its promise to offer alternative arenas promoting civic deliberation among people with diverse opinions. In the wake of this perceived failure of the online environment, activists, educators and scholars alike have begun to turn to alternative forms of civic engagement, both online, offline and mixed. Larp, live role playing, is one such form. Larps create cultural, artistic spaces offering great potential for alternative engagement with politics. Furthermore, Larps are not restricted to physical space. Rather, larp exemplify how social spaces can be deliberately and collaboratively designed to be conductive of inclusivity and democratic engagement. Studying larp, enhancing their capacity of supporting democratic engagement and political expression, and learning from them to inspire the deliberate design of social media and other spaces for political expression, thus directly answers to the call topic and opens unique opportunities for the design of future spaces for democratic deliberation, including future social media.The project will produce:- Studies and experiments chartering capacities of larp in supporting democratic engagement and fostering democratic skill-building- Public events in collaboration with designers and organisers from marginalised and vulnerable communities- Design exemplars of larp and larp spaces capable of supporting inclusivity and democratic engagement.- Evidence-based Democracy by Design Toolkit- A widespread community of Experts understanding the capacities of larp and larp-like spaces in fostering democratic engagement.- Evidence-based Policy Recommendations supporting policy-makers in multiple domains


**Keywords:** Larp, Deliberation, Democracy, Role-Play, Marginalized Communities, Social Space De
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'The Human Immune System mouse as a new model to study HIV vaccination'.

assistant: **Concept**

The study of development and function of the immune system in vivo has made intensive use of animal models, but performing such work in human beings is difficult, for experimental, practical and ethical reasons.Confronted to this scientific challenge, several pioneering groups have developed in the late 80s mouse models of human immune system development. The system has now been considerably improved with the Human Immune System (HIS) mouse that exhibits a complete human innate and adaptive immune system.This new model is extremely suitable to test the response of the human immune system to candidate HIV vaccines in an in vivo setting. I propose in the present project to validate the HIS mice as a new model to study HIV vaccination. For infection, we will use a new promising strain, the HIV-rtTA, a conditional live-attenuated virus.In this virus, the replication is controlled and dependent on the presence of a non-toxic effector molecule and thus can be turned on and off at will in a graded and reversible manner. This drug-dependent virus will provide a unique reagent to study the virus-host interaction and viral pathogenicity in vivo.As a vaccination approach, one would like to limit virus replication to the extent that is needed to mount a protective immune response, after which replication is stopped and subsequent virus evolution is blocked.The use of HIV-rtTA virus in the HIS mouse will provide relevant information on the requirements for a vaccine to obtain protection against HIV. Overall, this project will contribute to the validation of the HIS mouse model as a tool for pre-clinical tests.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Five-Dimensional Localization Microscopy for Sub-Cellular Dynamics' under Horizon 2020.

assistant: **Concept**

The sub-cellular processes that control the most critical aspects of life occur in three-dimensions (3D), and are intrinsically dynamic. While super-resolution microscopy has revolutionized cellular imaging in recent years, our current capability to observe the dynamics of life on the nanoscale is still extremely limited, due to inherent trade-offs between spatial, temporal and spectral resolution using existing approaches.We propose to develop and demonstrate an optical microscopy methodology that would enable live sub-cellular observation in unprecedented detail. Making use of multicolor 3D point-spread-function (PSF) engineering, a technique I have recently developed, we will be able to simultaneously track multiple markers inside live cells, at high speed and in five-dimensions (3D, time, and color). Multicolor 3D PSF engineering holds the potential of being a uniquely powerful method for 5D tracking. However, it is not yet applicable to live-cell imaging, due to significant bottlenecks in optical engineering and signal processing, which we plan to overcome in this project. Importantly, we will also demonstrate the efficacy of our method using a challenging biological application: real-time visualization of chromatin dynamics - the spatiotemporal organization of DNA. This is a highly suitable problem due to its fundamental importance, its role in a variety of cellular processes, and the lack of appropriate tools for studying it.   The project is divided into 3 aims:1. Technology development: diffractive-element design for multicolor 3D PSFs. 2. System design: volumetric tracking of dense emitters.3. Live-cell measurements: chromatin dynamics. Looking ahead, here we create the imaging tools that pave the way towards the holy grail of chromatin visualization: dynamic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photonic Advanced Research And Development for Integrated Generic Manufacturing' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of PARADIGM is to effect a fundamental change in the way photonic integrated circuits (PICs) based on indium phosphide (InP) are designed and manufactured in Europe, with the aim of reducing the costs of design, development and manufacture by more than an order of magnitude and making more complex and capable designs possible than ever before.<br/>The key step is to develop a generic platform technology for application-specific PICs. This will be achieved by adopting a similar methodology in the field of photonics to the one that has been so successful in microelectronics.  The new approach developed in PARADIGM will be indispensable in creating a sustainable business sector with potential for significant future growth.<br/>PARADIGM addresses the whole product development chain from concept, through design and manufacturing to application.  It will establish library-based design, coupled with standardized technology process flows and supported by sophisticated design tools.  Our goal is to develop technical capability at the platform level, rather than at the level of individual designs, greatly reducing the cost and time required to bring a new component into production, whilst allowing the designer great freedom for creativity at the circuit level.<br/>To establish a generic, design-rule and library-based methodology for photonic ICs is an ambitious and demanding task, which could only be contemplated with a consortium possessing a wide range of complementary skills.  PARADIGM has brought together just such a collaboration of Europe's key players in the fields of III-V semiconductor manufacturing, PIC design and applications, photonic CAD, packaging and assembly.<br/>The project will verify the potential of the generic approach by fabricating a number of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Study of the molecular mechanisms involved in the beneficial effect of high CO2 levels to preserve table grape quality during the storage at low temperature' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Low temperatures induce numerous cellular and physiological disorders, such as an increase in respiratory rate, reduction of photosynthetic activity and generation of reactive oxygen species causing a set of visible symptoms known as chilling injury in crops that are susceptible to cold. To overcome these alterations, fruit activate a number of defense mechanism that includes synthesis of pigments to protect from photoxidative stress, enzymes to reduce oxidative stress and an increase in the levels of cryoprotective and antifreezing proteins. Although table grape is classified as tolerant to chilling injury, non-treated grapes responded to temperature shifts in the first stage of storage at 0ºC activating defense responses related to the phenylpropanoid pathway, whereas the application of high CO2 levels reduced these responses. In addition, previous studies indicate that the efficacy of gaseous treatment reducing decay in table grapes was not mediated by the induction of pathogenesis-related proteins (PRs), such as chitinase and β-1,3-glucanase. All these seem to indicate that although table grape is tolerant to cold injury it senses temperature shifts triggering a stress response, and the treatment with high CO2 levels could be participating in the perception of low temperature by the fruit, alleviating partially this stress and improving fruit quality. However, very little is known about the biochemical and molecular mechanisms involved. Thus, having as a final goal the improvement of the quality of table grapes during the postharvest period, we aim to obtain a comprehensive understanding of the molecular mechanisms involved in the differences observed in response to low-storage temperature between table grape bunches non-treated and treated with high levels of CO2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'High Voltage Aerospace Cable System' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Current research and development is focusing on propulsive energy components for hybrid aircraft. This will open the path to an all-electrical aircraft. Power levels are predicted to be between 2 and 4MVA for hybrid systems and up to 40MVA for all electrical systems. This will require the transmission of electrical power across the airframe at previously unseen scales. This will not be possible without the development of power dense and safe cabling systems that operate at higher levels of voltage and current. To this end, the objective of HIVACS is to bring together a coherent suite of experimentally validated simulation models to permit the design exploration and optimisation of future aerospace cable systems to allow the aeronautical industry to meet the high-power design requirements of future aircraft programs. The project will also provide recommendations for future standardisation to the relevant standard committees and identify key axis for further development. After performing a state-of-the art review, a requirements and Failure Mode Effect and Analysis (FMEA) will be performed on the design and manufacturing processes on a selection of designs. A range of existing models will be used to assess the performance of these designs with these being adapted to the aerospace environment. The models will be validated by comparison to experimental test bench activities undertaken on existing cables. Once the models are qualified and accepted by NEXANS as being appropriate for adoption in an industrial setting, they will be used in a design optimisation process to determine optimal geometry and sizing of the candidate cables and predict their expected performance. With an optimum cable design, two cable types will be produced using different manufacturing techniques. Bo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development and application of hybrid joining in lightweight integral aircraft structures'.

assistant: **Objectives**

The main objective of the DAHLIAS project is to optimise hybrid joining (Refill Friction Stir Spot Welding, RFSSW, with an adhesive sealant bond) for application in aircraft structures. RFSSW is a solid-state joining technology especially applicable to lightweight alloys in similar and dissimilar configurations. The process has been successfully applied to difficult-to-weld and non-weldable alloys and is considered a potential replacement of mechanical fastening. Overlap joints in aircraft structures require the use of sealants for corrosion protection reasons. Using sealants with an adhesive function would complement the high quality joints produced by RFSSW by not only protecting against corrosion but also contributing to the overall mechanical performance of the structure. To achieve the main goal of this project a work plan consisting of eight work packages has been devised. Two work packages are focused on the RFSSW process development using standard samples with and without adhesive sealant. In parallel the adhesive sealant technology, including surface pre-treatment will be developed. The hybrid joining solution developed in this project will be compared to conventional joining technologies to define its potential. Hybrid joining brings a number of advantages to production and performance of aircraft structures. The change from differential to integral design introduces new challenges in the analysis of mechanical performance. Hence, the damage tolerance behaviour of hybrid joints is also investigated in this project. Quality control methods will be investigated by selecting NDT methods and by process control based on online monitoring of parameters. In the last phase of this project technology demonstrators will be produced to evaluate the capabilities of the pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Assocgov' (ASSOCGOV), addressing dissemination and exploitation.

assistant: **Impact**

Associations are central to some systems of economic management, but, despite its greater reliance on outside input to policy making when compared to member states, not yet to the EU. EU wide business associations offer the prospect to support public policy making, and to implement policy initiatives aimed at stimulating wealth creation through the encouragement of global sectoral competitiveness, but certain characteristics of associations, their environment, and member incentives may account for differences in their governance and hence their ability to contribute to EU wealth creation.