RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Theoretical and numerical studies of stochastic resonance systems' under Fourth Framework.

assistant: **Concept**

It is proposed to undertake fundamental research into the behaviour of externally forced stochastic nonlinear systems which are known to exhibit the phenomenon of stochastic resonance. Theoretical analysis of these systems will be carried out to establish the range of validity of current linear response theories and a general theory of noise induced linearisation - an effect which is believed to be of some importance in its own right - will be established. The full phenomenology of this nonlinear response of these systems will also be established using a recently developed theoretical approach. Digital simulation will be used as a guide to the theory and as a general probe of system dynamics  It is anticipated that the results of this work will significantly enhance our general understanding of nonequilibrium systems and form a firm theoretical base for future research in this field. Given the potential technological applications of stochastic resonance it is also expected that this work will aid in the future exploitation of this effect. On a personal level, the research project will enable me to improve my theoretical skills and learn new techniques in digital simulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Twinning IZTECH in Robotics Manufacturing Systems' (TWIN-IT-ROMANS).

assistant: **Concept**

When prototyping or producing a machine or its parts, several methods of manufacturing are used, such as machining, additive manufacturing, laser cutting or welding. These manufactured parts are investigated for their manufacturing tolerances upon production via quality control systems, such as a coordinate measurement machine. However, at the current state of the art, one production machine can only perform its one designated process. Additionally, these machines are generally large and bulky computer numerical control systems. As a result, these manufacturing machines are heavy and non-portable products with high investment costs. For these reasons, small investors or start-ups cannot invest in these machines, or very few of them can invest in only one type of manufacturing machine.  The aim of this project is to develop a lightweight, portable and low-cost manufacturing cell that can perform precise manufacturing and quality control. This challenge can only be solved by the collaborative work of interdisciplinary partners. Inspired by this action, Izmir Institute of Technology (IZTECH) has been firmly committed to developing and promoting enabling technologies for robotic and manufacturing systems. However, IZTECH could not fully exploit its technological and innovation potential in this field due to limited resources in research and project management. There is a clear need for concrete partnership between IZTECH and internationally leading counterparts to bring this potential into play, and thus to spread scientific excellence in robotics and manufacturing systems over the European Research Area and industry. In this way, Türkiye's excellence capacity and resources can be improved, and the research and innovation gap between Türkiye and the European Union can be cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Cell-type-specific computations for depth perception from motion parallax'.

assistant: **Concept**

To guide behaviour, the brain must infer the structure of the external world based on incomplete and unreliable sensory inputs. In the visual system, the signals available to the brain are limited to the two-dimensional images formed on the retinae. To reconstruct the three-dimensional location of objects in the environment, visual circuits must infer the missing depth information. This ability is innate in most mammals, not requiring visual experience, and involves the neocortex. While animals take advantage of both monocular and binocular signals to estimate depth, binocular vision is not necessary for depth perception. Animals’ innate capacity for depth perception is thought to rely on visual motion as an essential depth cue. However, we lack a mechanistic understanding of cortical circuits that process visual motion to estimate depth.The innate nature of depth perception suggests that it is mediated by specialized cell types, but how different cell types that make up the cortical microcircuit respond to three-dimensional visual stimuli has not been investigated. In proposal we will record their activity in virtual reality environments, where motion parallax acts as the only cue of depth, and determine how V1 cell types encode depth information. We will then test the hypothesis that V1 cell types make distinct contributions to depth judgments using a behavioural task that challenges mice to discriminate depth based on motion parallax. Finally, we will characterize the circuits underlying these computations by identifying monosynaptic inputs onto single depth-selective neurons and study how they give rise to their response properties using computational models.This project will advance our understanding of specialized circuits in the visual cortex supporting depth per
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Water conservation in turf management (AQUAGUARD)' under Fifth Framework.

assistant: **Concept**

The quantity of water required for irrigation of recreational turf grass is a major factor limiting the quality and location of sports turf throughout Europe. Omega sciences, a marketing division of Service Chemicals plc has developed an innovative water conservation treatment which has been successful in basic laboratory and field tests in the UK. The aim of this proposal is to determine the potential of the product within the European Community and to develop the necessary research and business infrastructure to bring the product to market. The RTD objectives are :. Characterization of physical and chemical properties of the water conservation treatment. Characterization of the biological modes of action of the product.Characterization of water requirements of turf grasses with or without the product.Characterization of disease incidence in turf grasses with or without the product.Characterization of nutrient requirements of turf grasses with or without the product.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Investigating interactions between plant roots and phosphorus in soil'.

assistant: **Objectives**

Phosphorus (P) is a scarce resource that is critical for crop production, but it is not being used sustainably. Excessive past fertiliser applications mean large amounts of P have accumulated in soil, losses of which are of major environmental concern. Nonetheless, the majority of soil-P exists in pools of very low bioavailability to plants, due to the high reactivity of P in soil. Increasing the ability of plants to take up P from applied sources (fertilisers) and from accumulated soil reserves would allow for reductions of fertiliser use and decreased potential P losses to the environment. Through evolution, plant roots have adopted several strategies to improve P capture, including: 1) architectural traits that affect the spatial exploration of the soil profile; 2) adaptive (plastic) responses to zones of high P supply (e.g. around fertiliser granules); and 3) physiochemical alteration of the environment in their rhizosphere. A challenge for the research community is to evaluate these properties and their potential benefits to cropping systems. As soil is inherently opaque, these traits are hard to study. Our current knowledge is fragmented because studies have generally used destructive sampling techniques, artificial media, and experimental setups making observations in 1D or 2D. Further advances of our understanding require in-situ visualization and quantification in real soil. This project will deliver such in-situ information, relevant to breeders and agronomists developing crop systems that make better use of applied and accumulated soil P. I will carry out this research under the guidance of Assoc. Prof. Sander Bruun of the Dept. of Plant and Environmental sciences at Copenhagen University and I will make use of the National X-Ray Imaging Facility (DANFIX) and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Diverging patterns of reproductive behavior within countries across the globe' under Horizon Europe.

assistant: **Concept**

Sweeping transformations in reproductive behavior are taking place worldwide. The DIVREP project investigates an unanticipated, yet critical dimension of these changes: increasing within-country disparities in childbearing age and fertility levels, identified primarily in nations with high levels of socioeconomic inequality. Such divergences and growing heterogeneity in reproductive behavior are vital aspects of social stratification that remain poorly understood and have never been scrutinized from a global perspective.DIVREP goes beyond the state of the art by being the first comprehensive global study of the patterns, trends, and determinants of within-country heterogeneity in two key aspects of reproduction: the age at first birth and fertility levels. Through the novel application of powerful—yet neglected in research on reproductive behavior—measures of distributional variation and by leveraging data from over 120 nations, DIVREP will make innovative contributions to our understanding of global fertility change. DIVREP will:1) Assemble microdata on the age at first birth and fertility levels for all countries with available information and estimate novel indicators of heterogeneity in reproduction, comparable across time and space. 2) Develop theories of fertility change by investigating global patterns and long-term trends in these indicators to uncover where and under what conditions reproductive trajectories diverge within countries.3) Uncover the role of individual-level socioeconomic factors in driving divergences in reproduction by performing decomposition analyses.4) Empirically study, for the first time, the links between macro-level factors related to socioeconomic inequality and reproductive divergences.Thanks to its pioneering scope, depth, and applicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'In vitro system for enhanced and tumor specific graft versus leukemia effect provided by tumor antigen specific donor cytotoxic t lymphocytes' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Allogeneic bone marrow transplantation for the treatment of leukemia in patients with acute lymphocytic leukemia (ALL) is used with increasing frequency. However, one of the major shortcomings remains the risk of leukemic relapse. In ALL of mature T-cells (T-ALL) the variable region of the T-cell receptor (VB) is unique for all monoclonal tumor cells, thus representing a 'tumor defining antigen'. In order to induce a graft-versus-leukemia reaction directed specifically against these tumor cells, HLA-matched, CD8+ T-cells will be primed in vitro by autologous dendritic cells presenting recombinant VB tumor antigen. In vitro primed cytotoxic CD8+ T-cells will subsequently be tested for their ability to specifically kill the T-ALL cells from which the recombinant VB was derived. If so, this in vitro model would open new avenues in the protection from leukemic relapse of T-ALL patients after allogeneic bone marrow transplantation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Enabling the European Nanomedicine Area until 2020'.

assistant: **Concept**

Nanotechnology applied to medical applications, Nanomedicine, is one of the most important emerging areas of health research and is understood to be the most promising out of the six KETs, for innovative devices and materials for personalised, targeted and regenerative medicine. However, due to the complexity of technologies and medical application areas Nanomedicine requires many different so far independent stakeholders from academia, industry and regulatory bodies. Due to the diversity of stakeholders the partners of this project will initiate a strong coordination and support action to build a pertinent European Nanomedicine community involving all key players necessary to define the resources, gaps and needs for development and implementation of nanomedical research into marketable innovations to be used by doctors for the benefit of patients. The implementation concepts will also target the initiation of Public Private Partnerships for the creation of novel infrastructures and innovative funding programmes.Nanomedicine research is growing fast in many countries. Therefore, the project consortium will initiate international collaborations in the Nanomedicine area, especially the coordination of international regulation of Nanomedicine products.The partners involved in the project represent major European networks combining academia, industry, clinicians and public authorities. Based on this strong partnership and after integration of further national and European initiatives the output of this support action will be a strong, established partnership of relevant stakeholders in identified key areas of Nanomedicine with new concepts for translation of nanomedical innovations into clinical practice and efficient and transparent communication channels. This will make N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Disorder and Order in the Conversion Mechanism of Metal Oxides in Lithium-ion Batteries' (DisorMetox), addressing dissemination and exploitation.

assistant: **Impact**

Binary transition metal oxides (MxOy) have been studied as anode electrode materials for Li-ion batteries (LIBs) for many years. Defined as a class of conversion material, these MxOy undergo multi-electron reactions (per formula unit) leading to highly desirable capacities and have drawn considerable attention. Over the last decade, most of the earlier efforts were devoted to material nanostructuring, which has proven effective to enhance the overall material performance. However, critical issues such as the large hysteresis and low Coulombic efficiency remain key obstacles hindering the commercial application of MxOy. To overcome these obstacles requires a good understanding of the reaction fundamentals, which has yet been achieved due to the challenges involved in the characterisation of these MxOy. Previous mechanistic studies found that these MxOy undergo a chemical pulverisation leading to coexistence of multiple nanoscopic/defected or even amorphous/disordered phases. In view of these complex structural features and high heterogeneity of the system, it is difficult for a quantitative and accurate phase identification and structural characterization using conventional analytical approaches. This proposal will, therefore, develop a novel approach based on reverse Monte Carlo (RMC) method using the X-ray/neutron total scattering data, to study the reaction thermodynamics of these MxOy in the LIBs with emphasis on the investigation of the (apparent) structural disorder and (hidden) order present in the system. The proposed project will target a series of iron and manganese oxides as model compounds because they are the most studied conversion MxOy and their stable phases manifest considerable compositional/crystallographic variations constituting a large library of ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inorganic therapeutic nanoparticles for osteoporosis' (INTO) under Horizon 2020.

assistant: **Objectives**

The aim of the proposed interdisciplinary project is to design, make and test novel nanoparticles that will have direct and rapid impact in osteoporosis. The unique aspect of these injectable nanoparticles is that they will deliver active therapy locally, to where it is needed, and that the cargo is not a conventional drug, but a sustained delivery of a combination of active inorganic cations and rare earth nanoparticles. Certain cations can promote bone growth and inhibit resorption and nanoceria can scavenge free radicals that would otherwise accelerate osteoporosis. Systemic concentrations of active agents will be much smaller that caused by taking oral drugs. Delivery will be sustained because it is controlled by the dissolution rate of biodegradable mesoporous silica nanoparticles, which will improve over biodegradable polymer capsules that often deliver a burst release of their drug cargo. Beyond the project, long-term impact could include slowing metastasis of tumours into bone (e.g. breast cancer to the sternum). The biodegradable mesoporous silica nanoparticles will be synthesised by sol-gel, while the nanoceria will be synthesized by co-precipitation method and microwave treatment and entrapped within the silica network. Key aspects will be: incorporation of active ions and nanoceria within monodispersed silica nanoparticles of controlled size; ensuring the particles remain dispersed in body fluid (control of surface chemistry); testing efficacy in cell co-culture (uptake and cell stimulation) and investigating the effect of the presence of the particles on immune cells. The effect of process variables on composition, particle size, bioactivity, degradation rate, radical scavenger ability and the cellular response will be investigated.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Molecular mechanisms of the regulation of mammary stem cell homeostasis and their subversion in cancer'.

assistant: **Innovation**

Stem cells (SCs) are thought to be integral to the development and progression of cancer, and their eradication may be essential for the cure of cancer. Yet, direct proof is lacking due to our poor understanding of the molecular differences between normal and cancer SCs. We will investigate normal and cancer mammary stem cells (MSCs) by focusing on the role of the cell fate determinant Numb in two signaling axes: Numb:Notch and Numb:p53. Numb is a tumor suppressor in human breast cancer. Its expression is lost, through increased degradation, in ~50% of breast cancers. These Numbneg cancers display overall poorer prognosis. Mechanistically, loss of Numb causes increased Notch signaling and decreased p53 signaling. Thus, Numb controls both an oncogenic pathway (the Numb:Notch axis) and a tumor suppressor one (the Numb:p53 axis). We showed that Numb is asymmetrically partitioned at the first division of normal MSCs and hypothesize that loss of Numb affects the kinetics of division and MSC fate. Our specific aims are to: 1. Define the role of the Numb:Notch and Numb:p53 axes in normal and cancer MSCs. We will exploit our capacity to propagate and isolate MSCs to near-purity, for biological, biochemical and  omics approaches. In this task, we will integrate knowledge derived from the analysis of real human cancers and of genetically-defined mouse models. 2. Define the broader biological context of Numb impact in stem cell biology, by analyzing the role of endocytosis in MSC fate determination. This is justified by the fact that Numb is an endocytic protein and that data in Drosophila indicate a complex role of endocytosis in cell fate specification. 3. Identify the E3 ligase responsible for Numb degradation in Numbneg breast tumors, in order to obtain druggable targets to re