RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards a Digital Critical Edition of The Works of Giuseppe Verdi' (DiCrEd).

assistant: **Concept**

Critical editions of 19th-century Italian opera have been appearing in print for over four decades, offering the basis for productions in major European theatres, as well as for audio and video recording with world leading singers, which continue to engage millions of people today. Established in 1983, _The Works of Giuseppe Verdi_ (University of Chicago Press and Ricordi) aims to publish all of Verdi’s music in a critical edition, relying on the rigorous criteria developed by its Editorial Board, but the traditional printed book format of this edition presents several practical limitations for users: in particular, it does not allow for simultaneous visualisation of alternative materials and for fruition of alternative versions of the score, and it precludes addition of newly available source materials to existing volumes.      DiCrEd is a multidisciplinary project aiming to address these limitations through the integration of the innovative instruments offered by digital humanities into _The Works of Giuseppe Verdi_, under the supervision of its general editor, Prof. Francesco Izzo (University of Southampton). DiCrEd employs the digital tools designed by the Edirom project (University of Paderborn) to develop 1) an applied model of digital critical edition with 2) an interactive system of fruition of the score, and 3) an applied model of digital critical edition of preparatory materials (sketches and drafts). The project uses Giuseppe Verdi’s French version of _Macbeth_ (1865) as a case study, making its full score commercially available for the first time. The project bears the potential to mark a turning point in the fields of musicology and textual criticism, with the long-term prospect of introducing digital instruments into the standard toolkit of the publishing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'SENSING USING QUANTUM OCT WITH AI' (SEQUOIA), addressing dissemination and exploitation.

assistant: **Impact**

OCT is a key imaging technology, allowing non-contact high resolution 3D imaging which has helped to save the sight of millions of people. However, progress has stalled since reaching the axial resolution (dz) limit of 1 um. Quantum OCT (QOCT) offers a step change x2 improvement in dz and greatly reduces dispersion. In addition, control of orbital angular momentum (OAM) reduces noise and improves edge and surface profile definition and discrimination of chiral objects. SEQUOIA will deliver the highest resolution OCT system ever built, protected from noise by artificial intelligence (AI) based OAM control in a real-world application: retinal imaging.Underpinning SEQUOIA is an ultra-stable, ultra-low noise comb source of unprecedented bandwidth (250-400 nm) which builds on NKT’s world-leading supercontinuum sources and adds new PTB techniques for stabilisation and noise control.AI-based algorithms (UPV) will be used at TUD to program spatial light modulators to encode high purity high-dimensional OAM onto the QOCT beams to increase resilience to noise and improve imaging quality.MPD will deliver new single-photon avalanche diode arrays specifically tailored for quantum imaging, to perform photon coincidence correlation at an unprecedented rate.NOR’s world-leading classical OCT software will be extended to create the first ever QOCT software.Theoretical work at NCU will develop the first mathematical models of noise in QOCT to optimise the spontaneous parametric downconversion.PTB will perform metrological characterisation of all relevant parameters and DTU will quantify the QOCT advantage over classical OCT.Retinal imaging using stable test standards from WWU will be performed, with automated AI-algorithms (UPV) to compare performance with classical OCT.ARD will perform a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Coordination of DNA replication and DNA repair at single-forks: the role of the Smc5-Smc6 complex in replication fork stalling and resumption' (2007-2013) under Seventh Framework.

assistant: **Objectives**

DNA replication represents a dangerous moment in the life of the cell as endogenous and exogenous events challenge genome integrity by interfering with the progression, stability and restart of the replication fork. Failure to protect stalled forks or to process the replication fork appropriately contribute to the pathological mechanisms giving rise to cancer, therefore an understanding of the intricate mechanisms that ensure fork integrity can provide targets for new chemotherapeutic assays. Smc5-Smc6 is a multi-subunit complex with a poorly understood function in DNA replication and repair. One of its subunits, Nse2, is able to promote the addition of a small ubiquitin-like protein modifier (SUMO) to specific target proteins. Recent work has revealed that the Smc5-Smc6 complex is required for the progression of replication forks through damaged DNA and is recruited de novo to forks that undergo collapse. In addition, Smc5-Smc6 mediate repair of DNA breaks by homologous recombination between sister-chromatids. Thus, Smc5-Smc6 is anticipated to promote recombinational repair at stalled/collapsed replication forks. My laboratory proposes to develop molecular techniques to study replication at the level of single replication forks. We will employ these assays to identify and dissect the function of factors involved in replication fork stability and repair. We will place an emphasis on the study of the Smc5-Smc6 complex in these processes because of its potential roles in recombination-dependent fork repair and restart. We also propose to identify novel Nse2 substrates involved in DNA repair using yeast model systems. Specifically, we will address the following points: (1) Development of assays for analysis of factors involved in stabilisation, collapse and re-start of sin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a low-cost 2Mw two-bladed wind turbine' (LOWCOST2BLADE2MW).

assistant: **Innovation**

This project addresses the challenge of decreasing the cost of wind power in a way to make it economically viable for general use. The wind turbine is two-bladed, since the potential economy generally is better, since it is better suited for optimisation at high wind speed sites and since it is easier to handle offshore.The main objective of the project is to fulfil the economical goal set up in the Work Programme. Other objectives are to realise the compact sub-critical teetering hub and the yawing system that is based on teeter angle measurements (both patent pending). The design origins from the 1MW Nordic 1000 which is the only large two-bladed wind turbine that is produced commercially today, with an excellent experience from operation of prototype and serial turbines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Decompensation of liver cirrhosis and progression towards acute-on-chronic liver failure (ACLF) causes 1.2 million deaths/year. Microbiome is causally involved in cirrhosis progression and is for drugs the first interaction point with the patients. Drugs can alter the microbiome leading to unwanted effects or even facilitating their effects, but the microbiome metabolizes the drugs, shapes their effects and possibly determines the host response to drugs. As each person carries an individual microbiome, insight in these processes should help stratify or even personalize patient health care and treatment. The aims of MICROB-PREDICT are 1) to better understand the role of microbiome and the gut-liver-axis interactome with respect to microbiome functionalities, 2) to identify and validate microbiome-based biomarkers and signatures for personalized prediction of decompensation and ACLF, and response to treatment, 3) to design three new tests as easy-to-use tools and point-of-care, smartphone-connected nanobiosensors, and 4) to validate them in a randomized controlled trial. MICROB-PREDICT will assemble existing data and samples from major microbiome initiatives in hepatology (12 international studies, >10,000 patients), and enrich them with holistic and in-depth analysis using cutting-edge multi-omics technologies of host and microbiome from different body sites in samples of >1,000 patients collected in a longitudinal manner with sequential visits and controlling for confounders. MICROB-PREDICT results will foster more accurate, personalized risk stratification and significant steps towards personalized treatment of decompensated cirrhosis and ACLF. World-leading microbiome specialists, technology leaders and clinical experts make this a programme of scientific excellence;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'MAnufacturing process for Cold-chain Independent VIrosome-based VAccines' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

MACIVIVA is a highly interdisciplinary consortium among well established and innovative SMEs with scientific excellence and complementary industrial world-leading experts with unique expertise and know-how in virosome technology, spray and freeze drying, large scale manufacturing and packaging. MACIVIVA will pave the path to other large scale thermostable nanopharmaceuticals products for therapeutic and prophylactic vaccines and other potential applications for direct application by non-invasive routes.Liquid products are inherently prone to physical and/or chemical modifications and degradations. Solid vaccine dosage formats (e.g. powder) may prevent molecular motion and shear-induced degradation, and slow down degradation involving water and oxygen radicals, resulting in improved stability and enhanced shelf-life of vaccines. The cold chain storage is still fundamental for preserving the bioactivity of most liquid and freeze-dried vaccines, and a reconstitution step prior to administration is required for freeze dried vaccines that are usually administered intramuscularly or subcutaneously. These reconstituted freeze dried vaccines harbor important instability and must be used within hours and kept refrigerated. Because most liquid and reconstituted freeze-dried vaccines are susceptible to degradations, it may affect the immunological properties of the immunogens, with unwanted immune responses or insufficient immune protection. For addressing liquid virosome-based vaccine instability and improving their shelf-life outside the cold chain, MACIVIVA will explore new galenic vaccine formulations through careful screening of excipients, stabilization and drying methods for generating new vaccine solid forms that can be easily self-administered. Robust “universal” manufact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Controlled growth and production in mammalian cell culture' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The long term goal of this project is to design a production process for pharmaceutical proteins which includes an extended production phase in non proliferating cells. This highly innovative process will address major current industrial problems and will be based on creative application of recent developments in molecular genetics. In particular, the novel process to be created and demonstrated in this Project has clear potential to improve significantly both the quality of the pharmaceutical protein and the amount of this product obtained. This new process is based on genetic modification of CHO and BHK mammalian production cell lines so that cell proliferation can be restricted at a chosen point of the process, providing an extended interval of protein production with minimal cell growth. This should allow long-term, high- consistency product formation under technically and economically favourable conditions. In separate but cooperating lines of research, two different types of control genes that interact in different ways with the cellular proliferation machinery will be introduced and conditionally regularly by the concentration of low-molecular-weight compounds in the medium. In one approach, expression of recombinant cyclin E, which activates proliferation in protein-free medium, will be repressed, resulting in restriction of further growth. Alternatively, proliferation inhibition will be accomplished by overexpression of an unusual tumour suppressor. Interferon Regulatory Factor 1 (IRF-l), which, unlike cyclin E, does not intervene with the cell cycle. Both of these novel proliferation control strategies will be evaluated in four specific systems: a CHO host, a BHK host, an industrial recombinant BHK cell line (B4B 1 from the Master Cell Bank of Novo Nordisk, pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Directed Evolution of Metastable Electrocatalyst Interfaces for Energy Conversion'.

assistant: **Innovation**

It is our aim to transform the research field of electrocatalysis from the established “initial (as-synthesized) state approach” to a data-centric understanding of the metastable active interface of electrocatalysts, constantly evolving under reaction conditions. We want to overcome the limitations of elemental or binary alloy catalysts by exploring and exploiting high entropy materials (HEM) as a discovery platform for sustainable materials, with the aim to identify in the extremely large, multidimensional search space new electrocatalysts that are both stable and active.To understand and control the active interface of HEM electrocatalysts, we combine the core expertises of the PIs: theoretical modelling and simulations, high-throughput synthesis and characterization, nanoparticle synthesis, electrochemical operando techniques as well as machine learning. Our synergistic approach will significantly advance these individual competences by key conceptual innovations: (i) Evolutionary screening of micro-libraries to efficiently identify stable materials covering the complete HEM composition space; (ii) Accelerated atomic-scale characterization of HEM surfaces by combining combinatorial HEM synthesis with atom probe tomography; (iii) High-throughput operando experiments with thin film material libraries; (iv) Developing inverse activity-structure relationships and theoretical descriptors for metastability; v) Implementing active learning approaches based on materials informatics and using a semantic data lake.We will establish a theory of metastability as a core concept for the understanding of electrocatalysis for the most important energy conversion reactions: oxygen reduction and evolution, and CO2 reduction. Instead of passively accepting the degradation of catalysts
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Genetic control of the establishment of axonal pathways in drosophila' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The peripheral nervous system of Drosophila provides a simple model system for the study of neural development. We will use this system to dissect the genetic program that underlies the establishment of specific axonal pathways. We will concentrate on the projection of leg chordotonal organs, which are internal proprioceptive organs, and see how it responds to the ectopic expression of two genes that direct the formation of other types of sense organs, namely cut and poxn which specify respectively the mono-and poly-innervated external sense organs. We will then use this system to assess what extend different elements of the projections can be independently affected and to identify which of the target genes of cut and poxn are responsible for the neuronal transformations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Equipment and Methodology for Multi-Dimensional Scanning Probe Microscopy' (MDSPM).

assistant: **Innovation**

The ability to perform scanning tunnelling spectroscopy simultaneously with a measurement of the vertical and lateral tip-sample interaction force and energy dissipation on selected atomic or molecular sites is the next revolution in scanning probe microscopy and will revolutionise entire areas of surface science.   The aim is to develop, manufacture and commercialise a new UHV low temperature multi-dimensional scanning probe microscope (MDSPM). The two dimensional force and energy dissipation measurement is performed via micro-fabricated cantilevers with relatively high spring constants (200-2000N/m) which are simultaneously driven on their flexural and torsional oscillation modes with sub-Angstroem amplitudes. The deflection sensing is achieved by a focussing Fabry-Perot sensor with an up to 100 MHz bandwidth and an unprecedented sensitivity down to 1 fm/sqrt (Hz). The high bandwith allows the detection of higher oscillation modes and harmonics. While high resonance frequencies are favourable to measure local energy dissipation processes arising from stochastic force fluctuations the detection of higher harmonics may be used to directly reconstruct the force field from a site-specific measurement performed at a selected surfaces site at one fixed tip-sample distance. The operation of the cantilever with ultrasmall amplitudes not only allows the direct measurement of the local force gradient but is ideal for scanning tunnelling spectroscopy with excellent signal-to-noise ratio necessitated by ultra-stable tip-sample positioning.   These advances in scanning probe microscopy instrumentation will not only allow to imaging of metallic, semiconducting and insulating surfaces with unprecedented resolution, but will revolutionize our understanding of entire areas of surface
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Research Center for Energy and New Technologies' in the context of a Seventh Framework call.

assistant: **Objectives**

Institute of Thermal Technology (ITT) affiliated with the Silesian University of Technology, Gliwice, Poland www.itc.polsl.pl, employs nearly 80 researchers among them 15 Professors. ITT enjoys national and international recognition in the field of energy research and education.The University is located in Upper Silesia, a highly industrialized part of Poland, undergoing rapid transformation from heavy industry to high tech region of significant economic growth.The three years project Research Center For Energy and New Technologies  (RECENT) of 1.7 million € budget is executed in collaboration with four partner institutions•School of Process Environmental and Material Engineering at the University of Leeds•Centre of Energy Resources and Consumptions, University of Zaragoza•Department of Energy Engineering at the University of Florence•VTT – Finland National Research CentreFrom the wide spectrum of research areas the staff or the Institute is engaged, three fields of cooperation with partner institutions have been selected:•economic, first and second law analysis of large energy systems•technologies for low carbon energy generation with special stress on oxycombustion and biomass utilization, CO2  separation and sequestration•advanced computer simulation techniques in energy sectorThrough commissioning of equipment, intensive bi-directional know-how exchange and networking, longer secondments of ITT staff at partner institutions, workshops, joint projects and twinning agreements the project aims at better integration of ITT in the European Research Area.The outcome of the project will also be the reinforcement of the already existing and creating new cooperation links with the industry with an aim of enhancing their competitiveness and promoting high tech solutions. The