RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Oxide fuels: microstructure and composition variations' (OMICO) targeting Fifth Framework.

assistant: **Abstract**

This project will study and model the influence of microstructure and matrix composition on oxide fuel behaviour in normal LWR operating conditions. The emphasis will lie on temperature and fission gas release which will be both monitored on-line.A matrix of six instrumented fuel rod segments will be irradiated under representative PWR conditions. The test matrix consists of three different fuel compositions (UO[2], (U, Pu)O[2] and (Th, Pu)O[2]), each with two microstructures (homogeneous and fine dispersed ceramic-in-ceramic). The experiment will provide unique information about the separate effects of chemical composition and microstructure on fission gas release.Extensive theoretical work will be performed to incorporate the different fuel types in existing thermo-mechanical codes and the experimental results of the in-pile and out-of-pile measurements will serve as the basis for code benchmarking and model development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multifunctional flax combine' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The flax harvest knows traditionally four manipulations on the field. For each manipulation another machine is necessary: 1. To pull the flax out and lay it back down 2. To take the flax up and turn it over 180 degrees 3. To deseed the flax and turn it again over 180 degrees 4. To bail the flax On the one hand, the necessity and complexity of four different machines keeps too many agricultural firms from investing in flax growing. On the other hand, more and more flax is being used in the automotive sector, with Mercedes-Benz, BMW and Audi as pioneers. Goal of the project is: Construction of a multifunctional flax combine which incorporates: 1. A pulling tool (1St operation) 2. A turning tool (2nd operation) 3. A deseeding tool (3rd operation) In a second stage gradually raising the capacity per hectare of each tool.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cascade reactions with Zeolites in compartmentalized settings' (CaZeo).

assistant: **Concept**

CaZeo uses zeolites to overcome thermodynamic barriers in cascade processes, instrumentalizing the zeolite micropores to compartmentalize the reaction space. As a pilot case, the endergonic hydrogenation of CO2 to CO inside a small-pore zeolite is coupled to an exergonic homogeneously catalyzed carbonylation of an alkene outside the zeolite, yielding in one step an ester product with a CO2-derived functional group. Critically, undesired alkene hydrogenation is impeded by the narrow zeolite channels. CaZeo’s overall chemical targets include: (i) to re-integrate CO2 into oxygenated compounds, like esters, aldehydes, glycolaldehyde, isoprenol etc., in which at least one oxygenated function is sourced from CO2, via a Reverse Water Gas Shift Reaction to CO, or via selective CO2 hydrogenation to HCHO; (ii) to use zeolites as generators of small, reactive (or even toxic) molecules like isocyanates or isocyanides, starting from safe precursors like N,N-dialkylureas or N-alkylformamides; (iii) to upgrade polyamide-6,6 by ammonolysis and an ensuing zeolite-catalyzed reaction that convergently transforms the N-functionalized molecular mixture to valuable 1,6-hexanediamine. In CaZeo’s conceptual framework, reactions are spatially partitioned and orthogonalized to each other, overcoming the incompatibility conundrum of catalytic cascades and the equilibrium limitations of isolated reactions. In a more advanced development, pore systems with different diameters within one zeolite crystal are used as compartments. Advanced X-ray absorption spectroscopy monitors the monometallic or cooperative bimetallic active sites in the zeolites. The spatial organization is visualized with high-resolution electron and fluorescence micro(spectro)scopies, giving shape to the envisioned compartments.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Interactive Urban Robot' (IURO) under Seventh Framework.

assistant: **Objectives**

The inability to cope with abstract commands confines today s robots to very constrained, well-controlled environments. To overcome these limitations, a-priori knowledge - preprogrammed or learned - is required. However, as objectives and situations may radically change over time there will always be knowledge gaps. Even if provided with sophisticated cognitive capabilities, sufficient information will not always be available in the environment to fill these gaps. Humans, however, are a rich source of information to be utilized, e. g. by asking for directions. Access to this source provides robots with a powerful means to improve its adaptability and cope with new situations as they arise. The IURO project explores the integration of information retrieval from humans into robot control architectures to complement their perception and action control capabilities. IURO follows a multi-disciplinary approach combining environment perception, communication, navigation, knowledge representation and assessment, and human factors studies as well as a novel robot platform for human-centred urban environments as a pre-industrial development. IURO focuses on several main aspects, which address core objectives of the call: perception and appropriate representation of dynamic urban environments, identification of knowledge gaps arising from dynamically changing situations and contexts not specified a priori, retrieval of missing information from humans in a natural way by pro-actively approaching them and initiating communication situations. Quantitative and comparative benchmark measures considering flexibility and robustness regarding navigation and interaction capabilities in real-world scenarios are developed. IURO targets novel technologies for new commercial service robots wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Maintenance of functional identity of Drosophila colour photoreceptor neurons', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal asks the fundamental question of how complex cells, such as sensory neurons, maintain the functional identities they acquire during terminal differentiation. It builds on my recent results which showed that in one photoreceptor neuron subtype of fruit fly Drosophila melanogaster, a green-sensitive Rhodopsin6 (Rh6, a  G-protein-coupled receptor that detects photons) not only functions in the phototransduction, but also signals to maintain repression of the sister receptor gene, the blue-sensing Rh5. This maintains in aging flies a mutually exclusive expression between the two Rhodopsins established during development. The signaling pathway that ensures this exclusion does not use key components of the phototransduction cascade and thus represents a new molecular pathway downstream of Rhodopsin signal. The main goal of this proposal is to elucidate the transduction pathway which mediates the Rhodopsin exclusion signal: Objective 1. Using Drosophila genetics I will focus on the role of negative modulators of phototransduction, Arrestin2 and Gprk1, in Rh5/Rh6 exclusion mechanism. Preliminary results suggest that loss of these genes leads to de-repression of Rh6 in blue photoreceptors, an “opposite” phenotype to loss of Rh6. These results will allow me to establish the logic of Rhodospin cross-regulation.  Objective 2. Based on strong preliminary evidence, I will determine the role that Hippo tumor suppressor pathway plays in transducing the Rhodopsin signal. This will provide important information about new upstream regulators of the Hippo pathway. 3. I will exploit my discovery of variability in Rh5/Rh6 expression patterns in wild flies to identify genes involved in the mutual exclusion of the blue and green Rhodopsins and to understand the ecology and evolut
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Research Infrastructure Technology Infrastructure For Impact', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Research Infrastructures (RIs) and Technology Infrastructures (TIs) are both essential and complementary elements for functional and efficient R&I ecosystems in Europe. They play a crucial role in strengthening European R&I capacities, from exploratory research to the development, validation and integration of innovative knowledge-based solutions into new products, processes and services. The RITIFI consortium, composed of RI and TI stakeholders from 19 European countries, aims to improve the integration and structure of the European R&I landscape. It will do so by developing a functional framework for the integration of RI and TI services tailored to the needs of end-users, by providing guidelines and methods to improve the visibility and access conditions of RI and TI to end-users, by developing an agile and TI-friendly governance model at European level; provide a comprehensive and multi-level analysis of the RI and TI policy landscape and propose an action plan to ensure alignment and synergies of access policies; develop a process for prioritisation and synergies of investment plans for RI and TI sustainability; raise awareness and stimulate the inclusive engagement of managers, users and policy makers in the development of an integrated RI and TI landscape The project will follow a 4-phase methodology: based on the validation of RI and TI concepts to ensure a common understanding, development of a strategic analysis of the TI landscape and a strategic analysis of the integrated RI and TI landscape in 5 selected areas. Based on the information gathered and extended beyond the selected areas, recommendations to policy makers and the RI-TI community will be drafted. In parallel, the project will engage with the community from the beginning, creating awareness, promot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Flad/nsf international bioethics institute workshop for bioethical training of life sciences faculty iii edition'.

assistant: **Concept**

Students in the life sciences face a variety of ethical issues. The students' mentors, faculty members, generally desire to be resources for students, but there is little institutional training, support, or reward for faculty who want to discuss ethics with students. FNIBI III aims at helping biological science faculty to integrate ethics into their courses and labs, teaching them how to discuss ethics with their students. FNIBI is a one weeklong summer workshop, designed to train a total of 24 life scientists from the EU plus 6 from the USA. FNIBI covers biodiversity, animals and the oceans, but with a narrower focus on agricultural biotechnology and Gomes. Results will include the training of life science faculty in formal ethics, the revision of their courses to cover bioethics, and the production of scholarly resources in life sciences ethics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ads and fast Reactor CompArison Study in support of Strategic Research Agenda of SNETP' to be submitted under Seventh Framework.

assistant: **Abstract**

The objective of the proposal is based on the outcome of PATEROS CA to assess more in depth the regional approach to P&T implementation. It will respond to one of the key-topics put forward by the Strategic Research Agenda of SNETP. The project intends to look at the economical aspects of the most realistic scenario for P&T with the hypothesis: limit the MA bearing fuel transport and limit the MA bearing fuel handling in and between all places such as at the reactor, at the fuel fabrication and at the reprocessing plant.We would like to assess the cost associated to implementing ADS’s or dedicated Fast Reactors as minor actinide burning facilities. The idea is to start from two fixed hypotheses: (1) we work in double-strata approach and look only at the second (“burning” stratum); (2) we assume a certain influx of minor actinide mass per year that needs to be burned. These two hypotheses will allow the project to avoid extensive scenario studies. The economic impact will be evaluated for investment cost, associated fuel cycle and operational cost but not the needed R&D cost. A crucial parameter to be established for both reactor systems is the maximal minor actinide (MA) content in a core loading. This maximal MA value is determined by operational safety criteria to be adhered by the dedicated burner. An evaluation of a number of safety parameters for the systems will give an upper boundary for the minor actinide mass present in the core. In order to not diversify the work, the project should define a generic and representative system for the ADS approach and the FR approach. For the ADS, one can benefit from the work done in the FP6-EUROTRANS on the EFIT design. For the FR, one could use an SFR or LFR as a starting point. However, the design should be optimized to the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Implementation and validation of a closed-loop neural interface to entrain brain rhythms and reduce motor symptoms in Parkinson's Disease', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Neurological diseases, such as Parkinsons Disease (PD), are the leading cause of disability in the world. The role of brain rhythms has not been completely understood but evidence suggest that specific motor disorders may be linked to abnormal brain oscillations. Researching ways to modulate specific cortical motor rhythms could lead to discovering more effective approaches to treat patients with neurological disorders affecting their motor condition. However, our current understanding tools are insufficient to access and interact with this kind of neural activity. Non-invasive neuromodulation protocols such as transcutaneous Spinal Cord Stimulation (tSCS) are raising interest in recent years to induce changes in the Central Nervous System (CNS) that can lead to functional improvement, while the side effects and applicability limitations of invasive procedures are overcome. Better understanding the interaction between neuromodulation protocols and brain rhythms is crucial for the development of interventions targeting pathological circuits which can favour plastic changes and the restoration of impaired motor functions. In RhytMods, I will develop a non-invasive neuromodulation platform to apply closed-loop stimulation protocols synchronized with brain oscillations decoded from the periphery with muscle recordings (high-density electromyography, HD-EMG). The platform will allow to explore the modulatory effects of brain-oscillations-dependent stimulation of the CNS to treat motor symptoms and its potential to entrain and disrupt neural oscillations linked to motor recovery in patients with PD. This research has the potential to transform our understanding of neurological disorders with pathological brain oscillations and to develop new minimally invasive and cost-effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Late Gothic vaults and their complex stone members: Recovering historical design procedures, implementing knowledge in restoration practice' (REGothicVaultElements).

assistant: **Concept**

The proposal aims to transfer the results of the scientific research on design procedures of Late Gothic vaults into the practice of restoration of the architectural heritage. These structures are extremely complex in their geometry, with complicated meshes of ribs soaring along three-dimensional curves and intersecting on multiple levels at the keystones. About the principles of their geometric design and the way of how the instructions for producing their single stone elements were formulated, a deeper understanding has been gained in the current research. However, at present this knowledge is not available in the restoration practice. Hence, in case of retrofit or the necessity of reproducing damaged stone elements, there is the risk of altering the peculiar geometric features and distorting the character of these unique masterpieces of historic architecture. A practical implementation of the scientific results, with the potential of significantly improving the quality of maintenance and restoration, can be achieved by defining practical working procedures that reproduce the original design principles, by documenting these procedures and by creating a demonstrator. For the development of these proposed working procedures, their testing and their dissemination among apprentices and specialized stone-masons, a collaboration with the Workshops or Fabrics of several major Cathedrals will be established, which are the institutions engaged in the conservation of Late Mediaeval and Early Modern stone constructions and in keeping alive the historical technical knowledge of stone masonry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Role of SIK3 in energy homeostasis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In the last decades, obesity has become a growing health burden hence the importance of understanding its pathophysiology and the need to search for new therapeutic targets. Yanagisawa/Funato Lab (Y/F Lab) has recently discover that a splicing mutation in the Salt-inducible kinase 3 (Sik3) gene is involved in determining sleep need , and as well in a likely defective energy homeostasis since mice mutant for exon 13 of the Sik3 gene present an obese phenotype. The main objective of my proposed action is to identify the role of SIK3 in the central nervous system (CNS) in the regulation of energy balance and study its suitability as a target to develop an anti-obesity therapy. To achieve this, I will use virogenetic approaches in Sik3-ex13 flox mice and a neuron-specific mutant mice line for exon 13 of Sik3 gene will be generated. The molecular characterization of the animal models will be conducted by using several cutting-edge techniques such as RNA-Seq and phosphoproteomics. The identified targets will be functionally analyzed using genetics approaches. In sum, by doing the proposed project I will expect to uncover the influence of a potential new sensor in metabolic homeostasis. Moreover, this work in combination with the one going already on in Y/F Lab in relation to sleep may allow to understand the interrelationship between sleep disorders and obesity.


**Keywords:** Obesity, SIK3, Energy balance, Central Nervous System