RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigating the causal effects of transposable elements on downstream transcription within genomic context' to be submitted under Horizon Europe.

assistant: **Abstract**

Transposable elements (TEs) make up about half of both the human and mouse genomes, playing a crucial role in genome plasticity and evolution. Most TEs have accumulated mutations that disable their transposition, but even fragmented TEs are often co-opted by the host into complex regulatory systems like promoters, enhancers and silencers, profoundly influencing gene and chromatin regulation. For example, a retrotransposon acts as a promoter to drive the expression of a specific isoform of Cdk2ap1, which is crucial for pre-implantation development. However, TEs can also trigger senescence and oncogene expression, making them a ""double-edged sword"" in biology. Given TEs’s dual role, the activity and regulation of TEs driving downstream transcription is extremely important for cellular homeostasis. Studies have suggested a potential role for TEs as promoters, yet evidence is fragmentary and indirect. The sufficiency of TEs in autonomously driving transcription, their interaction with genomic context, and differences between TEs in various genomic context remain largely unknown. The TE-Driver project aims to systematically and directly investigate TEs transcriptional activity and its regulation by genomic context such as DNA methylation, histone modifications and chromatin structure. TE-Driver will integrate representative TEs (MT2_Mm, L1MdTf_II, and B3A) into thousands of genomic locations in mouse embryonic stem cells (mESCs). TE integration sites will be captured via inverse PCR coupled with high-throughput sequencing, and transcriptome changes will be analyzed using Smart-seq+5’. The project will integrate these datasets with publicly available datasets on genomic context to evaluate TEs sufficiency in driving transcription within genomic contexts and elucidate differ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Automated Next Generation Sequencing for Diagnostic Microbiology' under Seventh Framework.

assistant: **Concept**

Sequencing platforms in diagnostic laboratories may aid both patient management by detecting resistance associated mutations, and public health measures, by determining phylogenetic relationships between infections from different patients. Current platforms are limited by the timeframe required for generating a result and by the limited sequence information provided on pathogens. To overcome these limitations PATHSEEK, a 42-month project, proposes to set up a disruptive diagnostic technological pathogen sequencing platform that will deliver in 24-48H, all possible drug resistance mutation as well as data on nosocomial infection, from one patient sample in one single assay. The PATHSEEK platform will open up a new era in clinical diagnosis and patient management by delivering, in one to two days, all the results needed to provide personalized treatment. The rapid delivery of results will ensure early, appropriate therapy thereby helping to reduce the development of drug- resistance and minimizing unnecessary, extra medical expense from the use of inappropriate drugs. Through its multiplex, ultra-deep sequencing capabilities, the platform will also impact public health management of nosocomial infections. At the local level, it will provide, in a simple and efficient manner, all data to control hospital-acquired infections and identify community clusters and transmission chains. At a larger scale, it will permit European and WHO Reference centres to follow, in real time, the spread of infection, allowing earlier interventions to mitigate pandemics.To achieve automated high coverage deep sequencing of any pathogens directly from clinical material for timely identification of drug resistance and outbreaks, PATHSEEK will develop a user-friendly diagnostic platform based on N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scalable and efficienT oRchestrAtion of Ethernet services Using Software-defined and flexible optical networkS-EU' in the context of a Seventh Framework call.

assistant: **Objectives**

The STRAUSS project aims to define a highly efficient and global (multi-domain) optical infrastructure for Ethernet transport, covering heterogeneous transport and network control plane technologies, enabling an Ethernet ecosystem. It will design, implement and evaluate, via large-scale demonstrations, an advanced optical Ethernet transport architecture. The proposed architecture leverages on software defined networking principles, on optical network virtualization as well as on flexible optical circuit and packet switching technologies beyond 100 Gbps.<br/>In particular, the STRAUSS project focuses on the integration and development of a) cost/energy efficient and extremely fast-performing switching nodes, based on variable-capacity and fixed-length optical packet switching technology for access and aggregation networks, and on flexi-grid DWDM optical circuit switching technology for long haul transport; b) highly integrated and scalable software defined optical transceivers supporting bandwidth variable multi-flows for flexible Ethernet transmission; c) a virtualization layer for dynamic and on-demand partitioning of the optical infrastructure offering virtual optical Ethernet transport networks (slices); d) legacy (e.g. GMPLS) and new (e.g. OpenFlow based) control plane approaches for control and management of  virtual slices and finally e) a service and network orchestration layer for the interworking and coordination of heterogeneous control plane and transport technologies to offer end-to-end Ethernet transport services.<br/>Outcomes of this project will be experimentally validated by means of demonstrations on large scale test-beds in EU & Japan. STRAUSS will provide technological roadmaps, technical approaches and deployment strategies aiming at shortening innov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Pressure control device for aerosol packaging systems' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

It would be safer and much more environment-friendly if normal air, nitrogen or carbondioxyde could be used in aerosol packaging systems (such as spray cans) instead of adverse propellants, such as propane and butane. However, until now the application of compressed gases is limited. because their pressure drops dramatically during the outflow , resulting in a poor and inconsistent spray-pattern of the product. This project is set up to research, develop and manufacture a prototype of an innovative Pressure Control Device (PCD) for spray can applications, which fits into the spray valve and uniquely ensures a consistent pressure during use. This opens the way to apply any gas as a propellant (e.g. normal air) in aerosol packaging systems.The PCD would solve the problems of:i) the greenhouse effect of traditional propellants and;ii) the flammable and explosive nature of traditional propellants;iii) loss of spray quality due to pressure drop if instead of traditional propellants compressed gases are used. Furthermore, the proposal addresses research to and development of a high-speed automated assembly method.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'War and Fun: Reconceptualizing Warfare and Its Experience' (WARFUN).

assistant: **Concept**

The overall goal of WARFUN is to offer a new understanding of war and soldiering through a study of the role and implications of fun for soldiers and veterans. An understanding of the complexity of soldiers’ participation in war requires an epistemic change in conventional approaches. This project builds on a central hypothesis: fun is a key component of war. This, in turn, paves the way for three sub-hypotheses on the capacity of fun to reshape social categories and social practice, alter the lived experience of war, and create new horizons of actions and forms of agency. From here, the project aims to: (a) theorize the role of fun in the construction of the “enemy”; (b) produce new knowledge on the normalization of war; (c) reconceptualize notions of agency, complicity, and participation in the context of war; and (d) produce new insights on sexual violence in war. These research objectives will be achieved through a comprehensive research design and a “progression model” that dynamically combines ethnography, archival research, digital ethnography, visual and participatory methods, military analysis, and scaling and translating approaches. The strategy for implementing the project, disseminating its results, and mobilizing networks will enable the development of a novel epistemological framework for theorizing the role of soldiers in war, which will advance the European research environment on the nexus between the anthropology of war and anthropology of emotions, the emotional turn in international relations, and critical military approaches. Precisely because of the intense suffering and hardships that humans endure in warfare, we urgently need a more nuanced understanding of war. WARFUN will provide an unprecedented opportunity to initiate a new intellectual proje
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Enhanced Research Activities in Stratigraphy' in the context of a Seventh Framework call.

assistant: **Objectives**

Robust stratigraphic correlations are essential in deciphering Earth History, yet there are crucial gaps and limitations in the current status of Cenozoic planktonic foraminiferal biochronology. Previous records are hampered by low resolution analysis, incomplete cores and/or lack of magnetostratigraphic age control. As such there is a critical need for high resolution biochronology to improve the accuracy of existing age calibrations. The applicant is in an ideal position to address these issues and contribute substantially to the development of the Cenozoic integrated time scale. Though “Enhanced Research Activities in Stratigraphy (ERAS)” I propose to significantly advance Cenozoic biochronology by producing detailed calibrations of planktonic foraminiferal bioevents. The proposed project is original and innovative, with finer scale stratigraphic analysis than any previous research in this field. The investigation utilizes new deep sea cores in the Pacific Ocean with expanded and complete sedimentary successions and well defined magneto- and cyclo-stratigraphies, which allow direct and accurate calibration of planktonic foraminiferal bioevents to the Geomagnetic Polarity Time Scale and Astronomical Time Scale. The proposed research is the cutting edge in Cenozoic biochronology and will set new standards by pushing forward the temporal resolution of biostratigraphic studies. The expected results will contribute to EU excellence by significantly advancing the understanding of the chronology of biotic evolution during the Cenozoic and will actively contribute to the EARTHTIME-EU Research Network Programme. It is envisaged that the Marie Curie Career Integration Grant will facilitate the reintegration of the researcher into the European research area by enabling interdis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Strategies for inclusion and social cohesion in Europe from education' (INCLUD-ED).

assistant: **Innovation**

INCLUD-ED analyses educational strategies that contribute to overcome inequalities and promote social cohesion, and educational strategies that generate social exclusion, particularly focusing on vulnerable and marginalised groups. Europe needs to identify these strategies that will in turn be used by policy makers, education managers, teachers, students and families, and contribute to shape new policies to meet the Lisbon goals.To this end, INCLUD-ED will- Analyse the characteristics of the school systems and the educational reforms that are generating low rates of educational and social exclusion and those that are generating high rates;- Analyse components from educational practices that are decreasing the rates of school failure and those practices that are increasing them;- Study how educational exclusion affects diverse areas of society (i.e. employment, housing, health, political participation) and what kind of educational provision contributes to overcome it;- Investigate how the educational exclusion affects diverse sectors of society, particularly the more vulnerable groups (i.e. women, youth, migrants, cultural groups and people with disabilities), and what kind of educational provision contributes to overcome their respective discrimination;- Analyse the mixed interventions between educational policy and other areas of social policies and identify which are making steps forward to overcome social exclusion and build social cohesion in Europe; and- Study communities involved in learning projects that have developed the integration of social and educational interventions that contribute to reduce inequalities and marginalisation, and to foster social inclusion and empowerment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'High performance light water reactor'.

assistant: **Innovation**

There is an urgent need to improve the economics and efficiency of Light Water Reactors (LWR), similarly to improvements made in fossil power plants. The concept in this project involves an LWR operating in thermodynamically supercritical regime. In a once-through concept, the water enters as water and exits as high-pressure steam without change of phase. Consequently, the reactor can be substantially simplified. This project will study in details the merit of a High Performance LWR (efficiency of 44%) by a highly qualified team of Research Institutes and industrial partners. The results will also benefit current LWR technology. The evaluation will concentrate on the following areas: state of the art status, basic design requirements, plant architecture, core design, neutronic/thermal-hydraulics (T/H) analyse, in-pile neutronics test, materials and corrosion, T/H tests, safety, economics, and option for a fast reactorThe principal results of this project include a clear state of the art of the HPLWR technology, determination of its technical merit and preliminary economic feasibility, identification of the main difficulties that may be encountered in the future development of this concept, and recommendations for future R&D programs since the concept was found to be feasible. The state of the art of nuclear reactors designed to operate at thermodynamically supercritical conditions have been reviewed and evaluated. The state of the art was discussed during the SCR-2000 symposium at the University of Tokyo on November 6-9, 2000 and the symposium Proceedings presents a comprehensive summary of the technology.The HPLWR project has proceeded on two parallel paths:1) independent evaluation of the University of Tokyo's supercritical water-cooled reactor design, and;2) designin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'A systematic and multidisciplinary approach towards understanding and therapy of the inborn lysosomal storage disease alpha-mannosidosis.'.

assistant: **Innovation**

Alpha-mannosidosis is a rare, degenerative and chronic disease with multiple factors contributing to the degrees of progression. Since these patients are born healthy and exhibiting a slow progression of clinical symptoms, an effective therapy initiated at early age would contribute to a normal development. Thus, this Project is undertaken to reach such a therapy. Due to the complexity of the disease, this Project requires an international effort with a plethora of different techniques and disciplines involved. The Project will aim to reach a critical mass of understanding on both the molecular and path physiological level, and to use this knowledge to develop new strategies for therapy, using a mouse model of the disease. Based on these studies a protocol for clinical trials in humans will be designed, and a company within the Partnership will initiate a commercial production of a therapeutic agent.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A light weight, recyclable, tracking support system, for solar photovoltaic modules based on inflatable polymer membranes' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

POLYSOLAR Short SummaryEstablished in 2009 in Berlin, Germany, Solardynamik provides renewable energy consulting services, conducts researches and develops innovative solutions for the solar PV sector. We have developed, patented and demonstrated an innovative, light-weight, tracking support system for solar PV modules based on a recyclable, inflatable polymer membrane. Support systems are used to hold solar modules in place and may be either fixed-tilt or tracking types. Tracking types orient PV modules toward the sun to improve efficiency.The main advantages of the system are: Up to 68% less cost than SoA and 70% lighter; Up to 30% more annual energy production than fixed-axis solutions; Compact and light weight - cost effective transport and installation, can be used on wider range of light weight structures; Can fully deflate under wind loads – suitable for use in hurricane prone regions; Up to 44% less CO2 emission in manufacture; Transparent body provides architectual advantages, allows light penetration when mounted as a lattice or when used with semi-transparent solar cells, lighting applications; 100% recyclable, and future polymers from renewable sources; Dual use of land with exisiting agricultual or other activity (eg carport).We expect to enter the market in 2017, after securing external funding of around €2.2 million. and predict a total net income in the range of €4.29 million over a 5-year period. Additionally we create 38 new positions in our company over that period.In Phase 1 our objectives are: 1.) to analyse the results of the prototype demonstration to identify potential improvements; 2.) to identify potential manufacturers of the system components; 3.) to further assess and protect our intellectual property; 4.) to perform a detailed study of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Environmental & Dynamical Effects in Computational Photochemistry' (EnPhoC), addressing dissemination and exploitation.

assistant: **Impact**

The use of light pulses in chemistry offers the perspective to finely control atomic and molecular motion in a way that not only redefines the vision of a chemical reaction in itself, but also opens a broad new field of applications and functional device miniaturization, generically called nanotechnology.In order to deliver upon this promise, it must be possible to accurately predict, not only individual molecular behaviour of excited states, but also its time evolution and how this behaviour is changed through the interaction of the molecule with its environment.The aim of the current proposal is to go beyond the individual molecule static picture, and advance our knowledge on the dynamics of photochemical systems and the effects of an environment upon them, but also to consolidate methodology and procedures that allow predictability and transferability of simulation results. This will be done by systematic comparison and assessment of different simulation methods at distinct levels of theory.This proposal combines high level electronic structure calculations and state of the art dynamics simulation methods to study the photochemical reactivity of Protonated Schiff Bases, a prototypical cis-trans isomerizing system, relevant for many photobiological processes. Namely the effect of a solvent environment on the reaction paths of multiple izomerization and on the extended crossing seam will be studied in detail. Dynamics of the system will be studied, using quantum dynamics and QM/MM methodologies, for the individual molecule and the environment.This proposal builds upon the highly complementary skills of the researcher in solvent effects and non-adiabatic dynamics, and the expertises of one of the world leading research groups in the development of electronic structure s