RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Uncovering the mechanisms of osteoarthritis in human knee applying spatial transcriptomics' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Osteoarthritis (OA) is the most prevalent chronic musculoskeletal disorder causing pain, morbidity and disability, giving rise to enormous healthcare expenditures and loss of work. The exact triggers and pathogenesis of OA are still poorly understood. Currently, there are no measures to slow down the progression of OA. Bulk tissue-based multi-omics and small-scale single cell RNA-seq studies focussing on chondrocytes and synoviocytes have identified novel cell clusters, supporting the hypothesis that OA is a disease of the whole joint. However, one of the key relevant tissues (bone) have not yet been studied. In addition, approaches to date have employed lengthy live cell extraction approaches that affect the transcriptome pattern. Finally, the spatial dimension of molecular changes in the osteochondral unit has not been studied to date. This work will fill this fundamental gap in our understanding of the molecular aetiopathogenesis and progression of OA by employing a novel cutting-edge technique, spatial transcriptomics (ST). ST acts like a high-throughput molecular microscope to allow visualisation and quantitative analysis of the transcriptome with spatial resolution in individual tissue sections, affording near-single cell resolution. SpatialArth will generate new knowledge on the molecular profile of the osteochondral unit and will identify with spatial resolution which cells are involved in the pathogenesis of OA. I will combine ST sequencing and protein expression data from cartilage and bone tissues from OA patients (matched tissues from intact and degraded regions of tibial plateau) and tissues derived from non-OA knee joints. Additionally, I will develop my computational genomics skillset, aiming to help fill the need for a much-needed next generation of inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Immunological Diagnosis of Familial Mediterranean Fever' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease worldwide. The disease is highly prevalent in countries of the Mediterranean basin, the Caucasus and the Middle East, with 1:1000 up to 1:500 inhabitants being affected in countries like Turkey and Armenia. FMF has further spread to other regions of the world with migrations of these populations in modern history and today. Colchicine therapy is the gold standard for FMF patients, but given the risks involved, correct FMF diagnosis is desired before onset of therapy. Diagnosis of FMF is currently based on clinical presentation, and is further supported by review of ethnic origin, family history and genetic analysis of disease-associated MEFV alleles. However, clinical and genetic diagnosis of FMF are complicated by significant overlap of the clinical picture with other autoinflammatory diseases, and over 280 FMF alleles of MEFV have been described. Common genetic tests focus on the most common mutations in exons 2 and 10 of MEFV, but mutations may also occur in other parts of the MEFV gene. Consequently, genetic analysis of FMF is sometimes inconclusive, and correct diagnosis of FMF may sometimes be delayed for years. Here, we describe an immunological assay that for the first time allows selective identification of FMF patients based on the differential inflammasome activation response of their blood monocytes. The availability of a single robust, affordable and convenient assay that immunologically stratifies FMF patients from other autoinflammatory disease patients will be instrumental for improving timely and correct identification of FMF patients for colchicine therapy, and (where desired) will enable more cost-effective selection of patients for genetic confirmation of MEFV mu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Health/well being, Global changes, and Sustainable transitions in University of Toulouse' (AToUT).

assistant: **Concept**

AToUT is the French word for advantage, asset, benefit like a trump card. AToUT offers to host 50 post-doctoral fellows in University of Toulouse (UT), in 3 scientific areas that are i) Understanding and promoting good health and well-being ii) Understanding global changes and their impact on societies iii) Accelerating sustainable transitions: mobility, energy, resources and industrial change.By addressing these societal issues, Post-Docs will enhance their ability to connect with the public sphere, fortify the link between research and society, and augment both their scientific and technical competencies, as well as their societal intelligence, a pivotal element in their career development and employability.We will welcome 50 researchers from around the world, each for a period of 2 years, transparently selected for their academic excellence, to address the strategic applied and scientific axes of the programme. The beneficiaries will be free to develop their own research project, they will receive support, supervision and mentoring by their host team and laboratories. Fellows will have access to a structured training programme to develop their scientific, professional, personal and soft skills. They will benefit from the international academic and business network of AToUT'S associated partners (5 competitiveness clusters and 16 international universities), set up to establish collaborations and prepare their future careers in one or other sectors.Fellows will be required to engage in open science, public outreach events.AToUT will last 60 months (3 November 2025 to 2 November 2030). Its implementation is based on a governance structure organised around the services of the University of Toulouse including a human resources department, a department of valorization and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamics and Thermodynamics in Mixed Dimensions' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

In ThermoDynamix, we explore experimentally and theoretically the physics of ultracold mixtures of particles evolving in a different number of dimensions. We will realize experimentally a mixed-dimensional system by laser trapping an ultracold mixture of fermionic 6Li and 40K atoms. By tuning the wavelength of the trapping laser, we will create a potential that will almost not affect Lithium, and at the same time will confine strongly the Potassium atoms in one, two or three dimensions to freeze their motion along these directions. Experimental investigations will be supplemented by a comprehensive theoretical study of the system, using both analytical and numerical tools, in particular Diagrammatic Quantum Monte-Carlo simulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Mapping Products on Social Tagging Networks: Insights for Demand Forecast and Positioning' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Social tagging is a new way to share and categorize content, allowing users to express their thoughts, perceptions, and feelings with respect to concepts such as products or brands with their own keywords, “tags.” With this system, products can be connected through user-generated keywords, and the rich associative information in social tagging networks provides marketers with opportunities to infer customers’ mental schema toward a product. This research investigates whether the semantic position of products on social tagging networks can predict sales dynamics. This research shows that product positioning maps utilizing products-to-tags networks have distinct informational value in predicting sales dynamics. More specifically, this research suggests that (1) books in long tail can increase sales by being strongly linked to socially popular keywords and well-known keywords with high degree centrality and (2) top sellers can be better sellers by creating dense content clusters rather than connecting them to well-known keywords with high degree centrality. Our findings suggest that marketing managers understand better a user community’s perception of products and potentially influence product sales by taking into account the positioning of their products within social tagging networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Signatures of the invisible' (SIGNATURES) targeting Fifth Framework.

assistant: **Abstract**

For the Science and Technology Week 2002 we are envisaging a Europe-wide festival of events that bring together several different forms of science and several different forms of the arts. The aim is to create an almost unprecedented dialogue between the worlds of science and the arts. There will be parallel events in five different European countries - linked together through the common theme and a series of web casts and an interactive website. In this way, the events will reach a wide, pan-European audience and will attract significant media attention. The aim is to widen the public's interest in scientific concepts using media with which they feel more at home (e.g.art, fashion or music). The five events are a new drama production in London, a science-art symposium in Lisbon, a musical performance at CERN, a fashion show in Rome and a video installation at ESTEC in the Netherlands. All of the events will have a strong scientific content. The Signatures of the Invisible" exhibition has set a precedent between leading academic institutions of science and art. We are confident that this experience will induce a significant step forward of the public's understanding of science through art."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Studying the Higgs boson from the top and understanding fermion mass generation' to be submitted under Seventh Framework.

assistant: **Abstract**

Understanding the origin of mass is one of the primary goals of elementary particle physics. In the Standard Model (SM) of particle physics the fundamental particles obtain mass by the Higgs mechanism, which predicts the existence of the Higgs boson. The discovery of the Higgs boson at the Large Hadron Collider (LHC) marks the start of a programme of experimental studies to determine if the Higgs boson has the properties predicted by the SM. This proposal aims to measure the production of the Higgs boson in association with top quark pairs (ttH). This process gives direct access to the coupling between the Higgs boson and the heaviest known fundamental particle, the top quark, and hence will provide fundamental information on the origin of fermion masses.The fellowship is a staged project, where the first part of the project uses the existing ATLAS data to make precise measurements of additional jet radiation in high transverse momentum top events. These measurements will provide the essential understanding of the main background to the ttH process and will also be of significant scientific interest in their own right. The second part of the project focusses on preparing the ATLAS data for the upcoming high energy LHC run, in particular commissioning the tracking detector that is undergoing a significant upgrade. This detector is essential to the successful detection of the ttH process. The final stage of the project will use state-of-the-art techniques to select the decay products of boosted top and Higgs particles. This will rely on the precise calibration of the techniques, which will be done in situ using the ATLAS data. The final outcome will be a search for ttH production, with the potential for a first direct measurement of the coupling between the Higgs boson an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Feeding, Educating, Dieting: a Transnational Approach to Nutrition Discourses in Children’s Narratives (Britain and Italy, 1850-1900)' under Horizon 2020.

assistant: **Concept**

‘Feeding, Educating, Dieting’ (FED) is a comparative qualitative analysis of mal/nutrition narratives, i.e. images of characters eating/fasting, in 1850-1900 British and Italian children's literature. Adopting a new historicist and discourse theory approach to comparative reading of British and Italian narratives, the project examines nineteenth-century trans/national discourses about child mal/nutrition and assesses children’s literature’s role in circulating these discourses. Child mal/nutrition is an increasingly concerning health issue in Europe, which prompted the EU to draw the Action Plan on Childhood Obesity 2014-2020. Concern for this transnational issue can be traced back to the late-Nineteenth century, a definitional moment for national identities. Countries with different histories and food cultures addressed the idea of growing a healthy nation looking at the raising middle-class values in a process that engaged food, health, and literature. Using England and Italy as a case study, FED examines a selection of 1850-1900 Italian and British narratives to develop a framework to analyse the circulation of nineteenth-century child mal/nutrition discourses through children's fiction, highlighting their transnational nature. This framework will outline the core features of characters eating/starving in the selected narratives and unpack how these conveyed dominant discourses about gender roles, social power, and the healthy body/mind. As an expert in the application of new historicism and discourse theory to Victorian fiction, in FED I apply my main theoretical framework to the traditional comparative approach used in children’s literature studies to increase our understanding of how literature and food culture merge in national identity discourses. On a larger sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Scientific and Technological Excellence by Leveraging LOFAR Advancements in Radio Astronomy' in the context of a Horizon 2020 call.

assistant: **Objectives**

The Institute of Astronomy with National Astronomical Observatory (IANAO) is the premier institute of astrophysics in Bulgaria, operating the National Astronomical Observatory, and the only one in Bulgaria engaged in radio astronomy (RA) and space weather (SW) research. It has recently taken a strategic decision to significantly expand its RA scientific arm, and to work towards adopting world-class radio observing capabilities. To this end, it has begun a collaboration with the Technical University of Sofia’s (TUS) Faculty of Telecommunications, a local expert institution with strong capabilities in phased antenna array communications. ASTRON is a world-class centre of RA science and technological development. DIAS is a world-leader in advanced astronomical studies and SW research. ASTRON and DIAS recognize the importance of a partnership with the IANAO for expanding the network of the advanced European distributed telescope LOFAR, as well as for enhancing its RA and space weather capabilities. The proposed “Scientific and Technological Excellence by Leveraging LOFAR Advancements in Radio astronomy” (STELLAR) project will address the goals of all four partners by significantly increasing the LOFAR technical and scientific expertise at TUS and IANAO. It will allow IANAO and TUS to develop and strengthen collaborations with ASTRON and DIAS. STELLAR is a major step towards the realization, utilization, and further development of a LOFAR station in Bulgaria. STELLAR will achieve its objectives through carefully planned trainings for IANAO and TUS staff at ASTRON and DIAS, including lectures, workshops, summer schools, and research staff exchanges. STELLAR will have a multiplicative effect for the Bulgarian astronomical and geophysical community as a whole through the develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Next generation mechanistic models of retinal interneurons' to be submitted under Horizon Europe.

assistant: **Abstract**

Ever since the work Hodgkin and Huxley, models of neurons have been essential for our understanding of neural computations. Such models have been developed at diverse levels of realism, from linear-nonlinear cascade or black-box models to detailed compartmental models. While these approaches are commonly viewed as incompatible, they have attractive strengths from an epistemic point of view. In this project, I propose to develop a new generation of hybrid mechanistic models that reconcile these levels of modelling: they will consist of a compartmental model for the neuron of interest with inputs approximated by black-box models. I will leverage the power of these hybrid models to tackle one of the most challenging questions in visual neuroscience: the staggering diversity of amacrine cells, a major class of inhibitory interneurons in the vertebrate retina. Despite their diversity, they are the least understood class of neurons in the retina, in stark contrast to the remaining circuitry. While in mouse more than 60 types of ACs have been identified by single cell transcriptomics, only a handful has been studied at depth. I will build on the latest advances in machine learning to develop a framework for efficiently inferring the parameters of a hybrid mechanistic model. To constrain the model parameters, we will acquire two-photon calcium and voltage imaging data during natural stimulation. Further, we will extend our framework to incorporate transcriptomic information about gene expression collected via patch-seq into the inference procedure, allowing us to map the amacrine cells to genetically defined types. Thus, in this project, I propose to develop a toolset to systematically uncover the role of retinal amacrine cells during natural visual computations, and link it to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'STARTS Prize - Grand prize of the European Commission honoring innovation in technology, industry and society stimulated by the arts'.

assistant: **Concept**

Science, technology and arts limn a nexus at which observers have identified extraordinarily high potential for innovation. And innovation is precisely what’s called for if we’re to master the social, ecological and economic challenges that Europe will be facing in the future. The STARTS Prize initiative will focus on the most forward looking collaborations at the crossings of art, science, technology, industry and society, will showcase achievements and encourage further collaborations and will honor the inspiring individuals and teams behind these achievements. Here, art is assigned the role of catalyst that propagates scientific and technological knowledge and skills among the general public and triggers innovative processes. Accordingly, the STARTS Prize is emphasizing, on one hand, artistic works that influence or change the way we look at technology, and, on the other hand, very promising forms of collaboration between the private sector and the world of art and culture. 8 prizewinning projects will be singled out for recognition in both categories and will be awarded each with €20,000. To provide the best possible environment for an international launch of the STARTS prize the project is linked to the PRIX ARS ELECTRONICA, one of the world’s premier awards honoring creativity and innovativeness at the interface of art, technology, science and society. The collaboration with the renowned institutions Ars Electronica, Waag Society and BOZAR allows a fast introduction to the relevant communities on an international scale and provide the necessary expertise. Their large international network assures recruiting the best possible experts to ensure a high quality in the evaluation and selection of the prize winners. The presentation of the awards and the exhibition of t