RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Validating predictive models of radiotherapy toxicity to improve quality-of-life and reduce side-effects in cancer survivors' in the context of a Seventh Framework call.

assistant: **Objectives**

Long-term side-effects of radiotherapy impact on the quality-of-life (QoL) of cancer survivors. These side-effects could be reduced if predicted in advance. Previous work identified clinical and biological predictors but a major, coordinated approach is needed to validate them so they can be used clinically. The EU has ~17.8 million people living with a prior diagnosis of cancer of whom ~7 million received radiotherapy. In the long-term, potentially 20% of those suffering with mild to severe side-effects (~1.4 million) might benefit from alleviation of symptoms, with resulting reductions in the cost of care in the EU.REQUITE aims to develop validated clinical models and incorporate biomarkers to identify before treatment cancer patients at risk of side-effects and use the models to design interventional trials aimed at reducing side-effects and improving QoL in cancer survivors who underwent radiotherapy.REQUITE will:1. carry out a multi-centre, longitudinal, observational study to collect standardised data and samples in breast, prostate and lung cancer patients;2. validate biomarkers with published evidence of predictive value;3. replicate published clinical models and incorporate replicated biomarkers to create validated predictive algorithms;4. use the prospectively validated models and biomarkers to design interventional trial protocols aiming to reduce side-effects and improve QoL in high-risk patients.REQUITE builds on collaborations with a proven history of data sharing, enlarged to a consortium with expertise in patient recruitment, knowledge management, biomarker testing and predictive model development. SME involvement for biomarker assays will facilitate future clinical implementation and commercial exploitation. The outcome of this project will be validated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unsteadiness in High-Speed Strong Shock-Boundary Layer Interactions' under Horizon 2020.

assistant: **Concept**

Travelling at high speeds entails overcoming adverse effects, such as regions of high heat transfer and surface pressures, unsteady shock waves, and fluid-structure interactions. The occurrence of shock boundary layer interaction (SBLI) close to the leading edge is common in high-speed intakes. When accompanied by separation, the interaction adversely affects the performance of the system. The adverse effects are more than just those related to the energy/efficiency budgets; the separation could be unsteady and 3-dimensional which imposes heavy unsteady loads (including thermal loads) on the structure. An understanding of the 3-dimensionality and unsteadiness associated with strong shock-boundary layer interactions thus becomes inevitable in view of controlling them, especially at high-speed Mach numbers, particularly in the context of intakes. The objectives of the propose study are:1) investigate experimentally the spatio-temporal organization of a shock induced laminar/transitional separation bubble near the leading edge.2) study in detail, the mechanisms responsible for the unsteadiness using advanced flow diagnostic techniques.3) propose and demonstrate novel methods of control of the unsteady interactions. The research programme will advance the frontiers of supersonic and hypersonic aerothermodynamics and propulsion and it will firmly establish a UK/European lead in research on shock-boundary layer interactions and their control. This programme will be supported by the excellent research environment provided by the host, Prof Kontis, University of Glasgow UK, with state-of-the-art facilities for research development, testing and training. This programme will also benefit from the strong links between the host group and leading UK and international research groups
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'International conference on rice genetic resources and breeding for europe and other temperate areas krasnodar (federation of russia), september 2001' (1998-2002).

assistant: **Innovation**

International Conference on Rice Genetic resources and Breeding for Europe and other temperate areas, Krasnodar (Russia), September 2001. This conference will be a unique forum for interaction among the scientific and technical communities from U.E Countries, States in pre-accession to the E. U., NIS and CEECs Countries not in the pre-accession phase, dealing with breeding, production and development of the commodity chain for rice. The concerned area exceeds one million ha. Based on the results obtained by the U.E. project RESS GEN 037, this conference aims at :i) preparing the collection and characterization of the whole genetic resources in possession of Eastern countries in order to make them available to all European breeding teams :ii) analysing the best ways for the valorisation of these genetic resources, in combination with modern biotechnologies. It should strongly contribute to meet the issues the European rice production is facing:increasing demand in quality and in quantity;competitiveness with big producer countries in Asia ;suitable development of European producing rice regions which are economically and ecologically fragile.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ANAEROBIC POLLUTANT DEGRADATION WITH OXYGEN' (POLLOX) targeting Seventh Framework.

assistant: **Abstract**

Contamination with organic pollutants is widespread in nature and a notorious threat to our water resources. Two central paradigms are currently understood to control biodegradation in groundwater and sediments: (i) Redox gradients and interphases between compartments are hot-spots for contaminant breakdown, and (ii) biodegradation is primarily limited by local electron acceptor availability, in particular of oxygen. My group has published leading contributions to this understanding in recent years, especially in elucidating the ecology of anaerobic toluene degraders in aquifers.This project now aims to question these established paradigms and to elaborate a ground-breaking new perspective of the role of molecular oxygen in pollutant degradation in anoxic compartments. The hypotheses at the heart of the project originate from a combination of own recent findings, partially inconsistent with the current understanding of process and degrader stratification at redox gradients. These are now interpreted in the light of exciting recent advances in the fields of electromicrobiology and oxygenic anaerobic respiration.POLLOX postulates that oxygen-dependent degradation of pollutants in anaerobic compartments is possible by two unrecognised physiological adaptations of degraders. I want to verify the hypothesis that filamentous Desulfobulbaceae can anaerobically oxidise toluene via long-distance (1-2 cm) electron transfer to oxygen across redox gradients (aim 1). Furthermore, I postulate that monooxygenase-dependent toluene degraders, in absence of external oxygen, can be active via self-sustained production of oxygen by nitric oxide dismutation (aim 2). POLLOX proposes to perform targeted lab experiments and field surveys to verify both hypotheses and to elaborate the ecologica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Co-benefits and synergies between biodiversity conservation, poverty alleviation and climate change mitigation from a social-ecological systems perspective' (CoBioPovCli) targeting Horizon Europe.

assistant: **Abstract**

CoBioPovCli addresses the question of how to conserve biodiversity, alleviate poverty, and mitigate climate change simultaneously, which are interrelated challenges that threaten human and environmental well-being. The importance of this topic is highlighted by the current context of the global COVID-19 pandemic and the Russia-Ukraine war, which have exacerbated these problems and their impacts on human and environmental well-being. The main gaps in this topic are: (1) lack of comprehensive data, especially on the dynamics of socio-ecological systems, (2) lack of integrated knowledge, and (3) lack of holistic approaches that consider co-benefits and synergies. CoBioPovCli aims to overcome the limitations and gaps in the current state-of-the-art by developing an integrated spatial planning approach that can achieve win-win synergies between biodiversity conservation, poverty alleviation, and climate change mitigation from a social-ecological systems perspective. CoBioPovCli will use literature, models remote sensing data, and other data sources to construct and apply the spatial planning approach, based on case studies, spatial analysis and scenario simulation. CoBioPovCli will generate new knowledge, data and solutions that are conceptually novel, scientifically rigorous and policy-relevant. It will enhance our understanding of the multiple values of biodiversity and its contributions to human well-being under changing climatic conditions. It will provide evidence-based recommendations and best practices for promoting more integrated and sustainable approaches that benefit both people and the planet. CoBioPovCli will also enhance Europes scientific and technical capacity and excellence in the field of co-benefits and synergies between biodiversity conservation, poverty
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel mechanisms of cell communication in the nervous system : physiology and function of the p75 neurotrophin receptor' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The goal of this project is to elucidate novel signalling pathways for cell communication in the nervous system using the paradigm of the p75 neurotrophin receptor (p75NTR). This receptor is at the cross-roads of biological processes important for the development, maintenance and function of the nervous system, including neuron survival/death decisions, axonal growth, responses to lesions and environmental stimuli, and neurotropic viral infection. Our strategy is to increase the knowledge base on the physiology and signalling capabilities of neuronal communication of general applicability. To this end, we propose studies o intracellular mechanisms of p75NTR signalling, cooperation with Trk receptors, structure-function relationships, novel second messenger molecules, target genes regulated by p75NTR, neurophysiological roles, and p75NTR gene promoter regulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Computational and statistical physics of granular media'.

assistant: **Concept**

Research objectives and content We shall advance the theory of the granular media, utilizing both computer simulations and analytical methods, with special emphasis on the following topics: 1. Static force propagation equations New approaches for solving the continuum mechanics of a granular assembly, particularly the long-standing closure problem, shall be further investigated and critically tested. 2. Molecular dynamics simulations of granulates We apply molecular dynamics (MD) simulations (in combination with an experimental collaboration) for studying the dynamics of the size- and stripe-segregation processes. 3. Methodology of computational physics of granular media We shall develop a new computational method by combining the best features of MD and cellular automaton simulations. The succesful method allows realistic simulation of systems which are beyond the reach of the present methods. Training content (objective, benefit and expected impact) Applied Research Training Grant shall be used in my training in the field of the granular media, thus significantly broadening the scope of the problems I am equipped to tackle as a maturing physicist. The suggested research projects are realistic, important for the basic understanding of the mechanics of granular media, and enable solution of many problems which have escaped the efforts previously. Links with industry / industrial relevance (22) The research group at Ustutt has active industrial collaboration with Statoil (Norway), X-RS (Paris), and common projects with German chemical industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multicomponent nanostructured materials for separation membranes' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

It is the objective of COMPOSE to develop new materials with predefined physical and chemical characteristics. The membranes developed will be based on new understanding of materials phenomena, especially in the Nan orange. COMPOSE focuses on the development of novel Nan structured materials for selective transport and separation. Two classes of materials will be developed in this project: Nan structured organic/inorganic hybrid materials and functional self-organized supramolecular copolymers. Organic/inorganic hybrid materials will be developed and manufactured into membranes for the selective separation of gases and liquids. During this development, new knowledge will be gained about the behaviour of composite organic/inorganic membranes, where the inorganic phase is composed of nano-particles. Among the materials to be developed are high free volume polymers filled with in-site generated inorganic phases and mixed matrix membranes consisting of polymer and dispersed carbon molecular sieve flakes. Exceptional gas fluxes and selectivitys are expected. Organic/inorganic hybrid membranes will also be developed for Nan filtration in organic solvents. The membranes envisaged can have enormous economic benefit for the chemical and pharmaceutical industry. The second route to totally new membrane materials is the self-organisation of block copolymers. Self-organisation is an important building principle of biological membranes. Building membranes by the same principle tries to imitate nature; even so the molecules used for synthetic membranes are very different from biological ones. This part of COMPOSE dealing with creating membranes by molecular self-assembly promises new paradigm in membrane technology and knowledge. Totally new membrane structures will emerge from this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Terahertz Integrated Biosensing from molecular, vesicular to the cellular and tissue level – TeraIBs' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

THz biosensorics is a strongly growing field of research, as many biomolecules and biomolecular complexes exhibit application-relevant intramolecular and intermolecular resonances in this frequency range, with great potential for a wide range of biomedical and diagnostic applications. The TeralBs project aims to develop a radically new technology based on THz radiation for biomedical detection and diagnosis, based on a team of Doctoral Candidates (DCs) with the necessary in-depth background in devices and systems, spectroscopic techniques and biomedical measurement knowledge using THz radiation. To this end, all DCs projects are built around three major technological challenges of THz technology for biomedical applications: the development of cost-effective, sensitive, integrated THz technologies; the exploitation of the high specificity multi-analyte capabilities of THz; and the development of flexible and reliable THz analytical instrumentation and robust information extraction. The DCs projects configure a research programme structured in three research lines, which guide all technological developments in the project: RL1 on biomolecules, RL2 on vesicles and viruses, and RL3 on organ-on-chip sensing. At the end of the project, all the technological developments will be brought together in three demonstrators: a modular all-electronic system for the read-out of metamaterial-based THz biosensors, a fully integrated photonic THz sensor for biomedical applications, and an organ-on-chip model that will be used to validate the different THz sensors and technologies developed in the project in a biomedical-relevant scenario. The multidisciplinary knowledge gained by the DCs will enable them to explore new concepts in the broad field of future biomedical applications, equipp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Gambling in Europe'.

assistant: **Concept**

This project uses an innovative anthropological approach to study gambling as a social and cultural activity, and uses these findings to establish a new research paradigm that is technologically astute, internationally focused and aggressively future oriented. Gambling in Europe is worth an estimated E89billion and is a rapidly expanding and changing industry. It is also a source of concern to legislators and consumers. Gambling legislation is not harmonised at the European level. National governments are currently moving at varying speedsbetween containment and revenue generation, driven on by operators who use constantly evolving technology to create new markets and exploit loopholes in existing ad hoc and obsolete legislation. Like legislators, the research community has failed to keep pace with these changes and continues to focus on quantifying and categorising gamblers and gambling activities within national boundaries. This project will craft a more critical and powerful alternative. Highly productive and proven anthropological approaches will be applied to foursystematically integrated case studies: the UK remote gambling industry, spread betting among Chinese financial services workers in Europe, land based gaming in Cyprus and gamblers and non-gamblers in the Italo-Slovenian borderlands. The project will establish the value of a systematic ethnographic approach to gambling by conducting research in a number of contrasting settings, across a number ofdifferent scales. It will produce high quality and robust data that will form the basis of a new research paradigm that matches the dynamism and internationalism of the European gambling industry today.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Preclinical in vivo validation of a glioblastoma neuro snooper electrical device' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Median survival for people that are diagnosed with glioblastoma (GBM) is only 15 months. Chemoradiotherapy and targeted therapies still fail to combat peritumoral relapse after tumour removal. Preventing peritumoral brain invasion is the main target to cure GBM. Our project aims to validate a proof-of concept for a new medical device (MD) ‘GBM Neuro Snooper’ in GBM animal models, a required step before initiating a clinical trial (Technology Readiness Level from 2/3 to 4). This MD will allow to define an in-situ electrophysiology profile of patients with GBM, after the tumor resection, to access a new mechanistic understanding in the brain tumour field as well as, new strategies for patient stratification and treatment. Already existing MDs with electrode wires are either very stiff or with a millimetric dimension. The ERC work will lead to a first generic, miniaturised prototype implant with moderate invasiveness and which design was validated in connection with neurosurgeons for the GBM application, validation of its Freedom to Operate in the context of continuous IP landscaping and the creation of an exploitation plan. In a long-term perspective, it will help characterise hyperexcitability in brain diseases such as tumors, but also epilepsy or the Alzheimer Disease. We will also investigate the effect of stimulation of the peritumoral tissue and the correlation with the recorded signals as a new electro-theragnostic strategy. We will address the ethics and social dimension of using such a MD and our exploitation plan will include the protection of intellectual property, business strategy and the preparation of a clinical trial after project completion. The project will be performed by a dedicated team that includes significant expertise in technical development, prec