RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multifunctional structures with quasi-solid-state Li-ion battery cells and sensors for the next generation climate neutral aircraft' (MATISSE) under Horizon Europe.

assistant: **Objectives**

MATISSE responds to the fourth bullet of the HORIZON-CL5-2021-D5-01-05 topic “expected outcome”, delivering improved aircraft technologies in the area of multifunctional structures capable of storing electrical energy for hybrid electric aircraft applications. This consists in integrating Li-ion cells into aeronautical composite structures, sharing the load-bearing function with the structure and achieving an aircraft structural element capable of functioning as a battery module. To do so, MATISSE will:• advance Li-ion battery cell technology, in a non-conventional formulation suitable for bearing structural loads: NMC811 (cathode), Si/C (anode) and bicontinuous polymer-ionic quasi-solid-state electrolyte (BCE), i.e. NMC811|BCE|Si/C, achieving 170-270 Wh/kg at cell level;• enable the functional integration of Li-ion cells into solid laminate and sandwich composite structures;• make the structural battery smart, by equipping it with on-cell and in-structure sensors, connected to a chip-based CMU (Cell Monitoring Unit) and PLC (Power Line Communication).MATISSE delivers a multifunctional structure demonstrator capable of power delivery, power management and safety monitoring. This consists of a full-scale wing tip (1.42 m × 0.69 m) for use in place of the current wingtip assembly installed on Pipistrel Velis Electro, embedding a module of 40 battery cells at 72 VDC. This will undergo a comprehensive testing and characterisation campaign, qualifying the technology at TRL 4 at the end of the project (2025). MATISSE will also encompass aspects related to flight certification, life-cycle sustainability and virtual scale-up, paving the way towards the application of structural batteries as an improved performance key enabling technology for next generation commuter and regiona
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The study of Hsp90 through the use of nuclear magnetic resonance, small angle scattering and calorimetry' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Proper protein folding is essential for cellular homeostasis.  Cells employ a large array of chaperones to ensure protein adopt the proper conformation. Hsp90 is an important chaperone and comprises of 1-2% of all protein is eukaryotic cells.  Additionally, Hsp90 is upregulated in cancerous cells to facilitate fast proliferation.  There are several X-ray crystal structures available for Hsp90 free in solution and interacting with its target proteins.  This combined with small angle x-ray/neutron scattering (SAXS/SANS) and Förster resonance energy transfer (FRET) data, demonstrate that HSP90 is a 90 kDa dimeric protein and undergoes large conformational changes throughout its function.  However, these crystal structures only provide a static picture of Hsp90 function so the molecular and dynamic details of these rearrangements are not well understood.  We will employ nuclear magnetic resonance spectroscopy (NMR) as a method to further probe these changes.  NMR can provide atomically resolved real time information of Hsp90 in solution either free or interacting with its targets.  Hsp90 contains three distinct domains, and we have individually isotopically label each domain.  This will allow each domain to be studied either independently or and in tandem with neighbouring domains.  Also a target protein, the glucocorticoid receptor (GR) protein, will be introduced to observe how the behaviour of each domain changes upon binding a client protein.  Through observing the changes in chemical shifts and relaxation rates we will be able to identify specific regions in Hsp90 which are involved in the binding of client proteins. We will also employ SAXS/SANS experiments to observe changes in orientation of the domains when interacting with the GR protein, and use isothermal titrat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of a new functional antimicrobial edible film for fresh meat products' (Meatcoat).

assistant: **Innovation**

The main scope of the MEATCOAT is the development of a new functional antimicrobial edible coating for meat packaging to improve the integrity of products during distribution and commercialisation. The proposed system will increase shelf-life of the product due to their antimicrobial characteristics. The present proposal aims help end-user communities of SMEs: the fresh food industry (and particularly fresh meat sub-sector) by developing a new concept of edible coating that will enable a better preservation and quality of meat products and a longer shelf life in the market. The second community is the coating manufacturers, who need new products to launch to the market, to remain competitive and support their growth.These communities represents mature sectors in Europe with annual revenues valued in €40,456M and require continues effort in research and development to get products in a very competitive market to attend the consumer demand with increasing level of quality. A huge amount of fresh meat is disposed everyday from market selves. Better ways of preservation would avoid this and produce huge saves in the full supply chain. In addition, there is pressure to develop new products based on renewable sources that can replace present oil-based plastics whose recycling activity is inefficient and expensive. EC legislation is trying to curb the landfill disposal of recyclable or non-recyclable plastics, by encouraging the development of new products replacing recyclable or non-recyclable plastic packaging. As a result there are high levels of innovation in green packaging(lightweight and bio-based packaging materials). On the other hand, all new developments and innovations in the packaging industry will have to meet the current European standards and regulations for fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'How the brain learns to see language' under Horizon 2020.

assistant: **Concept**

Written information permeates our digital society. Yet, surprisingly little is known about how our brains allow us to learn how to read, that is, to see language. An obvious solution would be to simply follow children that undergo literacy instruction in school. Schooling, however, broadly involves learning in various domains. Therefore, it would not allow any firm conclusions to be drawn about the specific neuroplastic effects of becoming literate. To surmount this challenge, SLANG moves the research setting to rural regions of Northern India where millions of children cannot attend school for economic reasons. These children will be taught how to read by local teachers (but not attend school) and scanned at a local magnetic resonance imaging facility using cutting-edge, high resolution techniques. Introducing an innovative dense-sampling design, I will walk new research avenues by tracking the emergence and refinement of literacy in a longitudinal, nonlinear fashion and at the single-subject level. Building on a novel experimental paradigm, my objectives are to uncover (1) how literacy creates a visual interface with the speech sound system (2) and the mental lexicon and (3) how literacy changes the way we process speech sounds. Meeting these objectives, I will pave the way for a neurobiologically grounded model of literacy learning. A translation of these insights into educational practice could help the EU and policymakers worldwide to lay the foundation for next-generation literacy instruction programs that are tailored to the specific resources of each individual learner.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nanoscale surface cues to steer cellular biosystems' (NANOCUES) under Sixth Framework.

assistant: **Objectives**

The overall Science and Technology (S&T) objectives of this project are to create a knowledge base and technical platform that can be exploited in the design and development of Nan biotechnological processes and devices, tailored to steer/monitor cellular function. The project team consists of 7 leading groups in Europe, representing the necessary interdisciplinary competence and the complementarily required for this purpose. The project includes all levels from materials design and preparation, Nan structuring, chemical patterning, andbiomolecular interactions up to the cellular level. There are a number of obstacles, which currently prevent a knowledge base and a technical platform from being realised. Some relate to the lack of suitable fabrication methods e.g. to produce Nan patterned non-fouling surfaces with functional arrays of macromolecules, some relate to a lack of suitable characterisation tools e.g. tools to characterize the interface between living cells and synthetic materials, others relate to a lack of understanding of molecular interactions at surfaces and of mechanisms of cellular interactions at bio interfaces. The scientific and technical work plan addresses critical issues of the different types (fabrication, characterisation and understanding of molecular and cellular interactions. The main deliverables from this project will bei) new fabrication tools for scale-scale patterned surfaces,ii) new characterisation tools, andiii) knowledge generated of the interaction of biological systems components with scale-scale patterns and structures. This outcome will provide a platform for the design and implementation for directing cellular function via surface nano-scalemolecular cues.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Development of New Tool Materials with Tailored Thermomechanical Properties' (TAILORTOOL).

assistant: **Innovation**

Improving tool behaviour can optimise forming processes undergoing severe thermomechanical solicitations which are used to obtain high performance components. FGM are particularly appropriate for developing high performance tools since they allow this optimization through a graded variation of their properties. This project aims to develop a new generation of FGM with: •Functionally graded thermal conductivity and wear resistance for hot stamping, forging and casting dies to enable controlled cooling in different regions of the die. In hot stamping it will allow obtaining microstructurally tailored components, with an improved performance and crash performance with optimized weight for safety related automotive components. In die casting it is expected to increase tool life and improve the mechanical properties of the casting. •Improved fracture toughness and wear resistance for cold forming through a gradual variation of the hard particles content. It will be done by an optimization of the properties of the microstructural constituents, i.e. hard particles and the metallic matrix, separately. •FGM with surfaces tailored to have high load bearing capability as a substrate for hard coatings. These aims will be achieved by:  •Microstructural design considering the thermomechanical requirements acting on tools, obtained from simulation of the heat transfer and stresses acting on each microstructural constituent. •Investigation into the relationship between the properties of the microstructural constituents and the macroscopic mechanical behaviour. A detailed investigation on the properties, size, morphology and surface modification of the hard particles will be made. •Thermomechanical laboratory tests to screen the developed materials. Materials will be characterised in te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MUSAE: a human-centred factory for a future technological sustainable development driven by arts' under Horizon Europe.

assistant: **Concept**

The European economy's Digital Transformation (DT) is crucial for preserving and boosting international competitive advantages (Digital European Programme).A green and sustainable transformation is a vital step for protecting the health and wellbeing of citizens from environment-related risks and impacts where digital techs are considered a critical enabler for attaining the European Sustainable Development Goals (SDGs). It is urgent to define innovative R&D models to systematically integrate artistic collaboration in Digital Innovation Hubs to provide companies with new forms of transdisciplinary collaboration aiming to explore future scenarios for technologies application using artistic practice to anticipate innovative products and services to meet the SDGs for innovation towards a sustainable and healthy planet.The project aims to set up the MUSAE Factory Model based on the Design Future Art-driven (DFA) method to be included in the (E)DIHs to strategically guide digital technology innovation and address future challenges in the food domain to improve people and planet wellbeing. MUSAE will build on a DFA method that merges the Design Futures method by POLIMI with Art Thinking approach by STARTS partner Gluon and UB - School of Art. The DFA will help artists envision future scenarios (5-10 years), critically reflect on them, and collaborate with technology providers to develop new technological solutions that meet the future humanity needs with a human-centred approach, opening up new markets and activities. Four technological partners will empower the approach by bringing relevant expertise in Artificial Intelligence-UB, wearables-ABACUS, robotics-PAL, human-machine-interaction-UoM. To validate replicability, the MUSAE project will set up and activate one factory w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'EUROPEAN RARE DISEASES RESEARCH ALLIANCE' (ERDERA), addressing dissemination and exploitation.

assistant: **Impact**

The European Rare Diseases Research Alliance (ERDERA) aims to improve the health and well-being of the 30 million people living with a rare disease in Europe, by making Europe a world leader in Rare Disease (RD) research and innovation, to support concrete health benefits to rare disease patients, through better prevention, diagnosis and treatment. This Partnership will deliver a RD ecosystem that builds on the successes of previous programmes by supporting robust patient need-led research, developing new diagnostic methods and pathways, spearheading the digital transformational change connecting the dots between care, patient data and research, while ensuring strong alignment of strategies in RD research across countries and regions. Structuring goal-oriented public-private collaborations targeted at interventions all along the R&D value chain will ensure that the journey from knowledge to patient impact is expedited, thereby optimising EU innovation potential in RD. To support its ambition and missions ERDERA has been designed as a comprehensive and integrated ecosystem of which structure can be compared to an institute encompassing three main parts: (i) funding, (ii) internal (in house) Clinical Research Network that implements research activities targeting clinical trial readiness of RDs and accelerating diagnosis and translation of research discovery into improved patient care, and (iii) related supporting services (Data, Expertise, Education and Training) as well as an acceleration hub that serve external and internal RD community, all supported by all-embracing coordination and strategy and foundational (inter)national alignment.


**Keywords:** translational research, diagnostics, therapy development, ATMPs, data, education, patients empowerment, public-private
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '4D Breast Imaging for Personalized Breast Cancer Treatment' in the context of a Horizon 2020 call.

assistant: **Objectives**

The next major step forward in the fight against breast cancer will be the introduction of personalized treatment. Such a precision medicine approach would maximize the rate of complete response, minimize ineffective therapy and morbidity, and eliminate the need for localized breast cancer surgery.To achieve this, I will create a novel functional imaging modality, 4D dynamic contrast enhanced dedicated breast computed tomography (4D DCE-BCT), capable of characterizing every different genomic, molecular, and physiologic region present in a breast tumor. 4D DCE-BCT will involve putting together the hardware necessary for the continuous acquisition of x-ray breast projections with advanced techniques, for a period of minutes. Combined with new image reconstruction, correction, and processing algorithms, these acquisitions will result in quantitatively accurate 4D images of breast perfusion, with voxels thousands of times smaller, and a temporal resolution 27x and a limiting spatial resolution 6x higher than those in current imaging modalities. Radiomics-based analysis of these images will allow me to fully identify and characterize the tumor heterogeneity, known to result in regions with different therapy resistance.Complete characterization of the tumor will allow for optimal neoadjuvant treatment planning, maximizing the probability of achieving pathologic complete response (pCR) and minimizing the risk of recurrence. Due to its relative affordability and safety, the use of 4D DCE-BCT for treatment response monitoring throughout treatment will be possible, making treatment adjustments possible, if needed. Finally, I envision that 4D DCE-BCT will be able to predict and determine that pCR is achieved, making surgery to excise any remnant viable tumor cells unnecessary.The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'DRop-on demand flexible Optoelectronics & Photovoltaics by means of Lead-Free halide perovskITes' under Horizon 2020.

assistant: **Concept**

DROP-IT proposes combining optoelectronics and photonics in a single flexible drop-on demand inkjet technology platform by means of exploiting the enormous potential of lead-free perovskite (LFP) materials. Specifically, novel crystalline structures beyond conventional ABX3 LFP (double-perovskites and rudorffites) will be computationally screened and chemically synthesized with superior properties as LFPs proposed in the literature. A(Sn-Ge)X3 (A=organic,Cs; X=Cl,Br,I) materials will be considered for initial benchmark devices.  The future of DROP-IT technology is envisioned at long-term in the fields of photovoltaics, lighting and printed integrated photonics. This will be possible by developing highly innovative fabrication routes (inkjet printing towards Roll-to-Roll) of LFP pioneering materials (in bulk and nanoscale) by low-cost, high throughput, sustainable, large-scale fabrication techniques on flexible substrates (PET, f.e.) to revolutionize future power, lighting and communication systems. DROP-IT major novelty relies on the innovative use of newly synthesized LFPs in combination with the use of affordable, mask-less, drop on demand inkjet printing onto flexible substrates. The targeted breakthroughs towards the long-term vision of our technology will be based on the following challenges: (1) Theoretical screening of different LFP compound families and chemical synthesis of most suitable ones in the form of nanocrystals and polycrystalline thin films, (2) Formulation of specific and suitable inks of these materials for (3) Inkjet printing of thin films on flexible substrates and (4) Development of stable optoelectronic and photonic devices (solar cells with 12-15% and LEDs with 14-18% efficiencies, amplifiers-lasers with low threshold) as proofs-of-concept for