RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for '6th Jenner meeting on glycobiology and medicine' under Fifth Framework.

assistant: **Concept**

Glycobiology is a relatively young field of research, which especially in the last decade, has shown to be of immense importance in health and disease. At the proposed High-Level Scientific Conference on Glycobiology and Medicine, the most recent findings will be presented regarding the important roles that carbohydrates and carbohydrate-binding proteins, (lectins) appear to play in development and maintenance of major chronic diseases like cancer, rheumatoid arthritis, cardiovascular disease, diabetes, infectious diseases and neurodegenerative disease, as well as in normal physiology. In eight different sessions the state-of-the art of the following aspects will be highlighted: glycosylation-dependent bacterial and viral infections, lectin and proteoglycan-dependent interactions in leukocyte homing processes to lymphoid tissues and inflamed tissues, congenital defects in glycosylation of glycoproteins and glycolipids, and the role of carbohydrates in tumour development and neuropathology, including Creutzfeldt-Jakob disease. All invited speakers are established specialists in their field and a keynote speaker will introduce each session. The program will bring together researchers from the various edges of Glycobiology and Medicine, which is a unique opportunity to further integrate the research efforts in this important field. Young researchers of Member and Associated States of the Community will present their results on posters. Six interesting posters will be elected for oral presentation.It is the aim of the proposed conference on Glycobiology and Medicine:(a) to bring together the specialists that are exploring from different angles, the biological roles of glycoconjugates in health and disease;(b) to provide a platform for the presentation of various-state of-th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The British Library of Political and Economic Science' (1994-1998).

assistant: **Concept**

Principal characteristics of the facility and of the support offered to users: The European Union Social Science Information Research Facility (EUSSIRF) will combine the specialist strengths of the BLPES and EUI to develop a facility to provide improved access to social science researchers in Europe to major library collections and related information resources. Together the complementary collections of both libraries will offer wide ranging resources for the investigation of European issues. Access to the academic environment of LSE and EUI, two leading centres of European social science research, will also stimulate and contribute to the quality of visitors' research. The project will be managed by BLPES, being accountable for the delivery of agreed, high-quality services and responsible for the overall strategic direction of the facility. The EllI will act as supporting partner. Research visits will be offered to socio-economic researchers to enable them to visit one or both partners of the facility and exploit their information resources. Special attention will be paid to informing researchers in less favoured areas of the EU about the facility. Support will be provided by a dedicated team enabling researchers to optimise their research; time. Advanced project planning will be facilitated by access via Internet to catalogues, and to BLPES Web Page, which details library services and resources. Visitors will be provided with dedicated study space within the facility, with access to networks and computing facilities. They will also be integrated into the activities of the European Institute at the LSE and will have access to the open seminars and conferences of the EUI. Quantity of access being offered and number of users who may benefit: It is estimated that up to 50
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dynamics in Aircraft Engineering Design and Analysis for Light Optimized Structures' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Today’s design and certification procedures of aircrafts are mainly based on conservative static loading which leads to additional weight and, potentially, to a structurally unsafe aircraft. The overall objective of the DAEDALOS project is to develop methods and procedures to determine dynamical loads considering the effects of dynamic buckling, material damping and mechanical hysteresis during aircraft service.Use of advanced analysis and design principles from DAEDALOS will partly remove the uncertainty and the conservatism of today’s design and certification procedures. DAEDALOS work will hence form the basis for improved common design practices by:1. Determining accurate dynamic load spectra to be used for structural sizing.2. Reducing the added weight of aircraft structural components due to conservative design in compliance with quasi-static loads by using more realistic equivalent dynamic loads. This goal will be achieved through improved introduction of the structure damping capacity and detailed analysis.3. Increasing structural safety using more realistic loading scenarios.4. Establishing new procedures for the definition of loads to be used during aircraft design and certification by authorities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biopolitics, Sovereignty and Political Conflict' (BSPC).

assistant: **Innovation**

This project is a philosophical attempt to address the question of political conflict. At this time what seems to matter most in the escalation of conflicts around issues like gender, minorities and the COVID-19 pandemic is the biological life of individuals and populations. This is problematic for the reason that politics is structurally ambivalent about natural life: it is productive and affirmative, on the one hand, and, on the other, it is lethal and negative. There is a wide agreement that this ambivalent relation of politics to life stems from how biopolitical power intersects with sovereign power, the power over life with the sovereign right of death. While studies in biopolitics often take this enigmatic nexus as the point of reference for further considerations and subsequently emphasise the imminence of the problems with violence and pacification, this project aims to go further than that by drawing upon Jean-Luc Nancy’s idea of technology as the condition of biopolitics to deconstruct and recast affirmatively the knot of biopolitical power and sovereign power. This re-articulation I argue provides a novel angle from which to review the conceptions of resistance and to consider the grounds of political conflict. To show the affirmative value of political conflicts, I apply my developed concepts to examine populist polarization and neoliberal pacification that beset biopolitical liberal democracies today. The 24 months or outgoing phase of this project will be carried out at Deakin University under the supervision of Prof. Vanessa Lemm. I will return to the University of Jyvaskyla for 12 months under the supervision of Prof. Mika Ojakangas.


**Keywords:** Deconstruction, Continental Philosophy, Jean-Luc Nancy, Biopolitics, Foucault, Political Conflict, Soverei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Investigating Visual Perception with Neurofeedback'.

assistant: **Concept**

A major unresolved challenge for neuroscience is to understand how any physical process, such as neural activity, can give rise to a subjective phenomenon, such as a conscious experience. This question has been empirically addressed by seeking to characterize patterns of neural activity that specifically correlate with conscious experience using neuroimaging. Such conventional imaging experiments are purely observational and cannot establish a causal role for any brain areas whose activity correlates with consciousness. Approaches that disrupt brain activity either temporarily (TMS) or permanently (stroke) have been used to address causality. Here I propose using a new approach to investigate causal links between brain activity and perception. I will use real-time fMRI with neurofeedback to teach participants to voluntarily regulate either the level of brain activity or of the functional coupling of areas within early visual cortex. I will then test how self-regulating activity (or coupling) at different pre-specified levels can influence processing of a visual stimulus presented near threshold. I hypothesise that the level of activity within early visual cortex, or the coupling between areas within the visual cortex, will directly influence objective detection thresholds. By identifying neural mechanisms that lead to perception of visual stimuli, this work seeks to explore the neural basis of visual awareness with a conceptually and methodologically new approach. The proposed research marks a potentially important methodological innovation, will illuminate processes fundamental to conscious experience, and will lead to important medical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SETDEPLOY - Driving the implementation of the SET Plan Action 8' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Bioenergy and renewable fuels are essential to achieving the EU's zero-emissions target and transitioning to a clean energy system. Bioenergy is essential for decarbonizing energy and transport sectors, especially long-haul modes like aviation, shipping, and road freight, where electrification remains challenging. The Strategic Energy Technology (SET) Plan identifies bioenergy and renewable fuels as indispensable technologies for meeting renewable energy and decarbonization targets. However, achieving these outcomes requires coordinated actions among stakeholders, alignment of priorities across member states, and effective implementation of enabling policies and technologies. The updated Implementation Plan of IWG8 must address emerging priorities, such as those introduced in the Fit for 55 package, REPowerEU, REFuelEU Aviation, and FuelEU Maritime initiatives, as well as ensure alignment with the EU’s 2030 and 2050 climate goals and the recently launched Competitiveness Compass for the EU. The SETDEPLOY project directly responds to these challenges by acting as a facilitator and enabler of the SET Plan’s objectives in renewable fuels and bioenergy. The project will strengthen stakeholder networks, foster innovation ecosystems, and ensure effective collaboration among member states, associated countries, and relevant stakeholders. By supporting the update and implementation of the SET Plan Implementation Plan, SETDEPLOY will address new policy priorities while facilitating the deployment of technologies and solutions at scale. Through its activities, SETDEPLOY will facilitate the critical next steps for advancing deployment, monitoring progress, and fostering cross-border collaboration, ensuring the EU meets its climate, energy, and sustainability targets while securing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantum approach to modelling high resolution Kelvin Probe Force Microscopy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Kelvin Probe Force Microscopy (KPFM) is one of the newest scanning probe microscopy techniques, that enables us to obtain information about electrostatics and charge transfer on a surface, measured via very sharp tip moving above a sample. However, the theory behind the KPFM measurements and all physical interactions between the tip and sample are not fully understood, especially for very close scans. We plan to use density functional theory calculations to reveal the unknown physics of close KPFM scans. We will prepare multiscale simulation package for the KPFM, which will work on quantum theory level as well as simplified fast mechanistic model level and which will cover a wide range of experimental conditions. This work will enable us to get additional information about the physics going on the scanned sample from the KPFM measurements and to employ KPFM as an additional source of information for structural identification. Finally, it can lead to general theory for chemical resolution in scanning probe microscopy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hematopoietic stem cell Apoptosis in bone marrow failure and MyeloDysplastic Syndromes: Friend or foe?' to be submitted under Horizon 2020.

assistant: **Abstract**

Deregulated apoptotic signaling in hematopoietic stem and progenitor cells (HSPCs) strongly contributes to the pathogenesis and phenotypes of congenital bone marrow failure and myelodysplastic syndromes (MDS) and their progression to acute myeloid leukemia (AML). HSPCs are highly susceptible to apoptosis during bone marrow failure and early MDS, but AML evolution selects for apoptosis resistance. Little is known about the main apoptotic players and their regulators. ApoptoMDS will investigate the impact of apoptotic deregulation for pathogenesis, correlate apoptotic susceptibility with the kinetics of disease progression and characterize the mechanism by which apoptotic susceptibility turns into resistance. ApoptoMDS will draw on a large collection of patient-derived samples and genetically engineered mouse models to investigate disease progression in serially transplanted and xenotransplanted mice. How activated DNA damage checkpoint signaling contributes to syndrome phenotypes and HSPC hypersusceptibility to apoptosis will be assessed. Checkpoint activation confers a competitive disadvantage, and HSPCs undergoing malignant transformation are under high selective pressure to inactivate it. Checkpoint abrogation mitigates the hematological phenotype, but increases the risk of AML evolution. ApoptoMDS aims to analyze if inhibiting apoptosis in HSPCs from bone marrow failure and early-stage MDS can overcome the dilemma of checkpoint abrogation. Whether inhibiting apoptosis is sufficient to improve HSPC function will be tested on several levels and validated in patient-derived samples. How inhibiting apoptosis in the presence of functional checkpoint signaling influences malignant transformation kinetics will be assessed. If, as hypothesized, inhibiting apoptosis both miti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards a regulatory framework for climate smart agriculture' (SMARTLAW).

assistant: **Concept**

Towards a regulatory framework for climate smart agricultureBetween now and 2050, there will be a sharp increase in the demand of agricultural products due to an increase of the world’s population, the rise in global calorie intake due to greater affluence, and the production of biofuels. The increase in agricultural production will be accompanied by an increase in the emission of greenhouse gasses. Agriculture is not only a major cause of climate change but in many regions of the world, it is also seriously impacted by climate change. Policy documents, mostly by international institutions, have endorsed climate smart agriculture (CSA) as a means to achieve production growth, while at the same reducing the emission of greenhouse gasses and adapting the agricultural sector to the changing climate. However, it is as yet unclear through what regulatory mechanism CSA can be achieved. The key objective of this project is to identify the main elements of a regulatory framework that enables, facilitates and stimulates the transition of conventional farm practices toward ‘climate friendly’ practices in the EU. Various methodologies will be used, such as an evaluation of the Australian Carbon Farming Initiative Act, to date the world’s only comprehensive regulatory instrument aimed at facilitating climate smart agriculture.The project is aimed to be a stepping stone towards a more ambitious research proposal (to be submitted to the European Research Council (ERC) in 2017) aimed at developing the regulatory instruments needed to make the entire European agricultural sector resilient to the impacts of climate change. MSCA IF enables me to be heavily involved in climate law research for two full years, which will give a boost to my scholarly career and provides me competitiveness u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The PIDDosome in Centrosome and Ploidy-Surveillance' in the context of a Horizon 2020 call.

assistant: **Objectives**

Tight control of the number of chromosome sets in a cell (ploidy) is fundamental for normal development and organismal health. Most cells in our body are diploid, yet, some cells, including cardiomyocytes or hepatocytes require a balanced increase in ploidy for proper function. Polyploidization is accompanied by an accumulation of centrosomes, structures needed for nucleating the mitotic spindle and ciliogenesis. Extra centrosomes, however, promote aneuploidy in proliferating cells by causing errors in chromosome segregation, underlying a series of human pathologies, most notably cancer and premature ageing. How polyploidization is controlled in organogenesis and how errors in ploidy control contribute to disease is poorly understood.  We recently demonstrated that the “PIDDosome” complex polices centrosome numbers in mammalian cells, alerting the tumor suppressor p53 in response to extra centrosomes. This is achieved by inactivating MDM2, the key-inhibitor of p53, by targeted proteolysis. MDM2-processing is mediated by caspase-2, a neglected member in a protease family that controls cell death and inflammation, activated in the PIDDosome. This exciting finding allows examining the consequences of deregulated ploidy and centrosome number in development and disease without interfering with p53, nor the cell fusion or cytokinesis machineries. This puts us in pole position to carry out an integrative study that aims to develop the PIDDosome as a new therapeutic target in cancer, related inflammation and in regenerative medicine. To meet this aim, we will define (i) the relevance of the PIDDosome in aneuploidy tolerance of cancer (ii) the role of the PIDDosome in controlling sterile inflammation and immunity (iii) the PIDDosome as a key-regulator of organ development and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Amyloid fibril structures explored by solid-state NMR' (SSNMR-AMYLOIDS) targeting Sixth Framework.

assistant: **Abstract**

Amyloid fibrils are self-assembled filamentous structures associated with a wide variety of severely debilitating human pathologies like Alzheimers disease, type II diabetes and the transmissible spongiform encephalopathies. Despite the immense medical importance of amyloid fibrils, no atomic-resolution structures are available for these materials yet. The aim of the project is to determine the structure of the carboxy-terminal part of the prion protein HET-s in its fibrillar state using solid-state NMR.For this fragment, the structure-infectivity correlation has been established, and the host laboratory has already collected information about secondary structure elements. Solid-state NMR is to date the only technique capable of obtaining the structure of such non-crystalline compounds. The state-of-the art methods in solid-state NMR of the host will be combined with the knowledge of the fellow in liquid crystal NMR to provide accurate structural restraints and obtain a structure at atomic resolution. In particular, new NMR experiments will be implemented using fully labelled and axially oriented protein samples. The information obtained by solid-state NMR will be completed with Electron Diffraction and Atomic Force Microscopy data. The results for the HET-s fibrillar system will give a detailed molecular explanation of the characteristic properties of the amyloid fibrils, in particular their unusual stability. This will help designing new drugs against amyloid diseases.