RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Towards targeting chemokine receptors CCR7 and CCRL1 to control the crossroads of tumor-host interactions' (CRITICS) targeting Seventh Framework.

assistant: **Abstract**

Current immunotherapeutic strategies to combat cancer are hampered by the ability of tumors to escape immunity necessitating new mechanistic insights into underlying molecular and cellular processes. Through orchestrating complex cellular moves and determining the positioning of immune cells, chemokines govern both productive immune responses and their silencing. Chemokines signal through classical G-protein coupled receptors (GPCRs) but also bind atypical receptors (ACRs). ACRs modulate chemokine availability and create functional chemokine patterns by either degrading or transporting them. Besides their essential role in tumor immunity, GPCRs can be expressed by the tumor cells themselves and contribute to the formation of metastases, a major cause of death in cancer. Importantly, ACRs are also expressed in tumors but their role in tumor-host interactions is not clear.The aim of this project is to take a comprehensive look at the contribution to tumor-host interactions of a paradigmatic chemokine axis with pleiotropic involvement in induction and suppression of immunity and driving tumor metastasis. We will investigate the roles of CCL19 and CCL21, their GPCR, CCR7, and ACR, CCRL1, in regulating tumor progression and orchestrating anti-tumor immunity and its suppression, including in the setting of experimental tumor immunotherapy. The proposed work will entail studies of transplanted murine tumors with hosts and tumors having modified expression levels of chemokines, their GPCR and ACR as well as using models with disrupted function of specific immune cells. The host provides state of the art facilities and profound immunological expertise, whereas the applicant brings complementary competence in molecular biology and cancer and will be able to synergize in order to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Elucidating Neuronal Susceptibility to Mitochondrial Disease' (NEUROMITO) targeting Horizon 2020.

assistant: **Abstract**

Mitochondria generate most of the energy cells require to function. Deficits in the mitochondrial energy-generating machinery affect 1:5,000 children and cause progressive, debilitating, and usually fatal pathologies collectively known as primary mitochondrial disease. To date, there is no cure for mitochondrial disease and existing treatments are highly ineffective and mostly palliative. High-energy-requiring cells, such as neurons, are especially affected in mitochondrial disease.  However, not all neuronal populations are equally affected. Furthermore, the molecular determinants of neuronal vulnerability to mitochondrial disease have not been adequately elucidated, representing a challenge for the development of efficient treatments for these pathologies. To improve on current knowledge on mitochondrial disease and to provide better therapeutic targets, this project focuses on developing ground-breaking mouse genetics and molecular biology tools that will allow the identification and dissection of the molecular determinants of neuronal vulnerability in mitochondrial disease with unprecedented definition. We will develop novel techniques to isolate both the mitochondrial and cytosolic translatome by using ribosomal tagging in vivo as well as to assess intact mitochondrial function with cell-type specificity and temporal resolution. These novel approaches will have a high impact in mitochondrial disease, with the overall aim of identifying novel therapeutic targets that will lead to effective treatments for mitochondrial disease. Furthermore, the high applicability of the tools generated will allow significant breakthroughs in the research of other pathologies with mitochondrial affectation such as diabetes or neurodegenerative processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The molecular and cellular logic of vertebrate neural development' in the context of a Horizon 2020 call.

assistant: **Objectives**

A central problem in biology and key to realising the potential of regenerative medicine is understanding the mechanisms that produce and organize cells in the complex tissues of an embryo. In broad terms, initially uncommitted progenitors acquire their fate in response to signals that control transcriptional programmes. These programmes drive cells through spatial and temporal successions of states that gradually refine cell identity. How these states are established and cell fate decisions implemented is poorly understood. To address this we use an experimentally tractable system – the formation of defined populations of progenitors in the vertebrate spinal cord. We take an interdisciplinary approach that combines our in vivo expertise with three recent advances in our group. First, we have developed in vitro differentiation systems and microfluidic devices that use embryonic stem cells to recapitulate development processes. Second, we have embraced new technologies that provide unprecedented ability to manipulate and assay single cells. Finally, we have established interdisciplinary collaborations to develop computational tools and construct data driven mathematical models. Using these approaches, alongside established embryological methods, we will establish a platform for manipulating and analysing mechanisms by which the multipotent progenitors that form the spinal cord acquire specific identities. We will identify the rules by which cells make decisions and we will define the design logic and network architectures that lead to distinct cell fate choices. The ability to: (i) follow the trajectory of a cell as it transitions to a specific neuronal subtype in vivo; (ii) manipulate the process in vitro and in vivo; and (iii) model it in silico, offers a unique system
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Freshwater resources in sub-Saharan Africa with emphasis on regional scale interactions of land use and climate' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme. CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Feasibility Study for the introduction into pre-clinical study domain of the first-of-a-kind Multi Organ On Device (MOOD) technology'.

assistant: **Objectives**

Advances in molecular biology have significantly increased the understanding of the biology of different diseases. Nevertheless, these advances are not fully translated yet into improved treatments for patients, specifically for what pertains to the oncological disorders. One of main reasons for this shortcoming is the lack of reliable in vivo models that accurately predict drug efficacy and toxicity, so to translate these results from preclinical studies to the clinic.  In present project we address the major challenge of the preclinical stage in drug development, by offering a proprietary Multi-Organ-On-Device (MOOD), being an advanced fluidic multi-chamber bioreactor, a 3D model of breast cancer tissue cultured onto a membrane mimicking the blood vessel barrier, which jointly reproduce the physio mimetic environment of the cancer disease. In this way, MOOD technology enables the execution of standard pre-clinical assays, such as tumor cell migration and intravasation, drug efficacy and toxicity assays, thus bypassing unreliable, costly and ethically relevant mice studies. The validation of the MOOD device paves the way for the replacement, reduction and refinement (3Rs) of animal studies on global scale, allowing for dramatic cost reduction in the pre-clinical stage and for accelerated time to market for pharmaceutical companies and CROs.  The objectives of this feasibility study will be the deep understanding of the market and its technological and economic requirements, so to properly stream line the industrialization of MOOD platform. We expect our MOOD technology to exert a disruptively beneficial impact on drug development process and thus, human health and national economies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spin-Orbit Coupling at Interfaces from Spintronics to new Superconducting effects' (SOCISS), addressing dissemination and exploitation.

assistant: **Impact**

In the proposed project “Spin-Orbit Coupling at Interfaces from Spintronics to new Superconducting effects” (SOCISS) the experienced researcher Dr. Juan Borge and the scientist in charge  Prof. Angel Rubio, Head of the Nano-Bio Spectroscopy (NBS) group at the university of the Basque Country (UPV/EHU), aim at stablish a complete description of interfacial spin-orbit coupling. This understanding will allow us to describe many transport, both electrical and spin, phenomena, and to include the effect of this interaction in normal and superconducting alloys. This study will be done following two different approaches; a theoretical description using effective kinetic equations, and through simulations performed with a computational platform combining recent theoretical developments in density functional theory and many body physics.SOCISS responds to two different purposes, the implementation of its results into the realization of new devices, and contribute to a deeper understanding on the fundamental relations in quantum mechanics. On one hand interfacial spin-orbit coupling looks one of the best alternatives to heavy atoms in the research of new materials with high values of the spin Hall and Edelstein conductivities. On the other hand SOCISS provides the perfect opportunity to gain some insight into the relation between the spin and the charge of the electron in equilibrium and non-equilibrium situations. The skills the researcher will acquire in computational methods and superconductivity will be essential in order to advance its career as an independent investigator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Kinetic Limits of Many-Body Classical Systems' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project studies the transition between dynamical laws governing the physical world at different scales. Our focus will be on large systems of interacting particles with random initial data, underlying the kinetic theory of gases and dilute plasmas. Central to this theory are the Boltzmann equation, and its appropriate modification for charged particles given by Landau. Their description of approach to equilibrium and irreversible behaviour is a legendary success in the physics of time-dependent phenomena. Nevertheless, the rigorous foundation of such equations remains a largely immature aspect of the theory. This is a major problem in mathematical physics and non-equilibrium statistical mechanics. The effective equations of kinetic theory are an approximation of particle systems ruled by the time-reversible laws of classical mechanics. But their validity should become exact in a suitable limit of large system size. In the last decade, there has been substantial progress in the derivation of kinetic equations from first principles. Such work is restricted to rarefied regimes. Results are available for models of interacting monatomic gases of identical particles. Besides the macroscopic equations leading the average behaviour, results have been obtained for fluctuations, large deviations, and for the random evolution of tracer particles. Equilibrium fluctuations are in itself of great interest, including results on long time scales which justify physically relevant applications.Most of the results hold only for an overidealized model of hard-sphere interactions. None of them is, with the present techniques, extendable to realistic interatomic potentials. The goal is to bridge this gap by proving the validity of kinetic theory for some of the most common interaction m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Janus nanoparticles liquid cristal phases and derived materials'.

assistant: **Innovation**

Textured materials opens definitive new possibilities for preparing new materials in various fields such as catalysis, optics, pharmacy. Recently, formation of mesoporous silicate and aluminosilicate molecular sieves from a self assembly process involving liquid crystal templates has been demonstrated to be promising materials. Unfortunately, these materials, prepared by conventional precipitation routes showed amorphous structures. These materials prepared by a precipitation route, developed amorphous mineral walls, and are not stable at crystallization temperatures. Producing textured materials for applications in catalysis, optics, etc, will require improved crystallinity of the mineral network. Researches in order to prepare textured crystalline materials are getting very active in this area and are presently carried out in mostly universities (U. of Santa Barbara, State Michigan University, Massachusetts Institute of Technology, University of Mulhouse). A new route to elaborate crystalline textured materials was developed at Rhodia and based on the self-assembly of nanoparticles. Some textured crystalline material developing hexagonal or lamellar were obtained using rare earth oxide nanoparticles. A new class of nanoparticles, amphiphilic nanoparticles, named Janus nanoparticles, was designed, processed and patented by Rhodia. A large range of Janus nanoparticles was defined. Uses of these Janus nanoparticles as new building blocks for textured crystalline materials will require a better understanding of the characteristics and self-assembly properties of theses new objects. This new class of amphiphilic nanoparticles should offer new opportunities for processing new structured materials. This project will involve various field of expertise: Colloidal Science, Phys
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Demographic and Phenotypic Signals of Population Responses to Environmental Change' (SPREC) under Seventh Framework.

assistant: **Objectives**

A major goal in biodiversity conservation is to predict responses of biological populations to environmental change. To achieve this, we must identify early warning signals of the demographic changes that underlie population declines. Some studies have achieved phenomenological prediction of sudden changes, but recent advances that link trait-based information with demography hint that a mechanistic understanding is within reach. I propose to develop a predictive framework by identifying the demographic and phenotypic statistics that can be used as early warning signals of demographic regime shifts. I have investigated links between ecological and evolutionary processes in changing environments for many years, and I will now build on this experience to develop a predictive theory. First, we will analyse unique long-term individual-based datasets from nine mammal species. The species represent a continuum of life histories and environmental conditions, and some of them show population dynamic regime shifts. Second, we will construct trait-based demographic models of each system and perturb key parameters to simulate population and trait dynamics under multiple environmental scenarios. The simulations will yield time-series data from which we will estimate demographic and phenotypic statistics. We will test the ability of these statistics to predict demographic changes using a novel decision algorithm framework. Finally, using two laboratory microcosms, we will experimentally test the ability of these statistics to predict population responses to environmental change. This project will exploit nine unique natural systems to identify early warning signals of population change and test these on two experimental systems. Results will provide much-needed predictive insight in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Avian flight: Integrating experiments with aerodynamic theory' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Here we propose a series of experiments on the energetics and aerodynamics of avian flight and migratory behavior, to be performed at Lund University.  In Experiment 1, we will be examining the effects of turbulence on the energy use of migratory birds in order to better understand how atmospheric conditions affect migrants and what effects climate change may have on them.  In Experiment 2, we will be quantifying both the energetic and aerodynamic costs of natural and simulated molt; molt is one of the most important life-history events in the avian annual cycle.  Finally, in Experiment 3, we will be studying the energetics of Common Swifts (Apus Apus) during both foraging flight and aerial roosting, when they are thought to sleep on the wing.  We will be using a combination of wind tunnel work and field observations, and will use our results to update theoretical models of avian flight behavior.  In the end, we hope to make significant advances in our understanding of avian flight and migratory behavior as well as form trans-Atlantic friendships which will result in future scientific collaborations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Scalable energy efficiency modules integrating both energy recovery and passive cooling systems for the solar photovoltaic industry'.

assistant: **Concept**

The optimisation of energy efficiency and the increase of renewable energies in the energy mix are key elements for the clean energy transition to fight global warming. Solar energy is the most abundant energy source on Earth and solar photovoltaics (PV) is the third most important renewable source in terms of global installed capacity. But PV energy conversion efficiency is below 20%, while 80% of the sun’s radiation energy is lost in form of waste heat. Furthermore, the heat excess on PV modules reduces their energy conversion efficiency and the high PV module temperatures under in real-life environment reduce the lifecycle of PV modules and increases maintenance cost. LightCatcher is a disruptive solution that simultaneously addresses PV energy efficiency and the problems created by waste heat in the solar PV industry: i) recycling of waste heat into electricity and ii) passive cooling of the PV device. The combination of both effects leads to solar-to-electricity efficiencies of up to 80%. By maximising electricity production and equipment lifecycle, while reducing CAPEX, maintenance cost, and ROI time LightCatcher will reduce PV levelized cost of energy in over 33%, helping the PV industry to become cost competitive against traditional energy sources. LightCatcher is highly scalable to find direct applications for the improvement of energy efficiency in a vast range of applications such as electric vehicles, air conditioning, or as a solution for cooling, and energy recovery and reuse in industry processes. LightCatcher addresses the global market for PV Balance of Systems (BOS) that was valued over €31.2bn in 2018 and is projected to reach €71.1bn by 2023, growing at a CAGR of 21.0% from 2018 to 2023. By successfully implementing the LightCatcher project, we expec