RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'DIFFERENCES – ARTISTIC RESEARCH IN THE EUROPEAN UNION (EU4ART_DIFFERENCES)' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project, presented for H2020 from the EU4ART Alliance, is entitled ""Differences"". It aims to raise each partner’s research profile, to promote a high-level culture of artistic research with a focus on artistic processes and crafts, and to raise academic excellence and strengthen the cooperation of all alliance partners by focussing on differences as a source of future-oriented exchange and development. Our strategic vision is founded on two pillars through which the consortium will successfully achieve the proposed objectives: building artistic research labs and graduate schools, and knowledge transfer. The program is structured in working packages designed for the development and implementation of the project. The strategic objective of the working package “Fine Arts Lab Establishment” is to provide a methodological framework for the establishment of R&I centres. The main objective of the working package “R&I Agenda and Transfer to Citizens & Society” is to develop a common framework for an R&I agenda and action plans as well as to empower art practice and art research within society. The working package “The creative eco-system” focuses on the creation of a shared fine arts ecosystem where the main themes of producing and managing the arts’ potential are investigated and used for training. One working package is in charge of the project dissemination strategy and will identify and organise the activities to be performed to maximise the influence of the project and to promote exploitation of the project results. Each participating university, according to its societal context, will develop its own research unit that will become part of the shared doctoral and postgraduate research community. There is a strong horizontal exchange between the working packages in e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In-kind transfers as instruments of redistributive policy' (1994-1998).

assistant: **Innovation**

In-kind transfers as instruments of redistributive policy  In my dissertation, I would like to investigate the role of in-kind transfers (public provision of private goods) in redistributive policies. The first part will extend recent theoretical contributions, in order to analyse the optimal structure of transfers if the tax policy is optimally designed (given the information structure). The second part investigates the role of public provision in a European setting characterised by potential tax competition and enhanced mobility. The third part attempts to apply the theoretical models to various transfer programs which have been used in EU member countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Large X-ray Detectors for Coloured X-ray Imaging' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

This proposal addresses the development of large x-ray detectors combined with photon counting read-out electronics to provide information on the energy of the absorbed x-ray photons that will help doctors improve their diagnosis and could lead to a reduction of radiation for patients.  The requirements for such X-ray detectors can only be met by semiconductor detectors. They provide high efficiency and high spatial resolution because semiconductors convert radiation directly into charge carriers. Although real progress has been made over the past years in the development of microelectronics and in material engineering resulting in novel devices, these improvements are not sufficient for the production of semiconductor detectors for large area x-ray imaging.   The dramatic improvement of readout electronics with resolution down to 55µm pitch in combination with high sensitive Photon Counting readout electronics that has been achieved recently opens the route to semiconductor detectors with a significant improvement figure of merit (high resolution & high sensitivity). The development of X-ray sensors is focused on CdTe and (Cd,Zn)Te which combine high sensitivity (high mobility lifetime products), high energy resolution (electron-hole-pair energy 4.41 eV), and sufficiently advanced micro-electronic technology. (Cd,Zn)Te sensors can operate at ambient temperatures and the material is chemically stable up to 1000 oC.  However, despite the clear potential of CZT technology for large area sensors no such system is presently available on the market. A possible solution to overcome these limitations is the deposition of CZT thick films with the required detector performance. This proposal involves 2 partners who intend to strengthen their collaboration in this field through a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'OLEAginous yeast platforms for FINE chemicals' (OLEFINE).

assistant: **Concept**

The academic and industrial partners engaged in the OLEFINE project have the joint vision of demonstrating the techno-economic viability and sustainability of biological production of insect pheromones for use as safe and environmentally friendly insecticide substitutes. Biological production of cheaper pheromones will be a market disrupting technology that willallow rapid expansion of pheromone-based pest management products. The partners behind OLEFINE have developed a novel technology for biological production of pheromones using oleaginous yeast cell factories, however the strains, fermentation, and downstream process need to be further optimized to bring the technology to the market.OLEFINE aims to optimize, validate, and commercialize biotech process for production of high-added-value chemicals(insect pheromones) for use as non-toxic insecticide replacements. Cost-efficiency and sustainability of the current processwill be lifted in this project by optimizing the yeast biocatalyst and by employing innovative fermentation and downstreamprocessing with cascading of resources. The production cost will be reduced by at least 75% in relation to the current state-of-the-art. The process will be validated in industrial environment for two pheromones (TRL7), techno-economic viability will be estimated and business plans will be prepared. The environmental impact and sustainability will be evaluated by full Life Cycle Analysis. The technology will be brought to the market by OLEFINE industrial partners post project. In summary, OLEFINE will bring new sustainable high-value chemicals to the market and create new business opportunities and jobs in European biotech sector, which is in line with the challenge of the topic.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of protein synthesis in axonal growth cone guidance' (2002-2006).

assistant: **Concept**

Basic knowledge of how nerve connections are established during development is essential for the development of clinical therapies in nerve repair. The correct wiring of the nervous system relies on the ability of axons and dendrites to locate and recognize their appropriate synaptic targets during development.Pathfinding by growing axons is guided by extracelluar guidance factors. Recently, it has become clear that guidance cues can trigger rapid and local synthesis, degradation and endocytosis of protein s, providing a fast and flexible way for growth cones to respond to cues in their microenvironment and adapt their responses to changing conditions.Key questions raised by these data are- what particular proteins are translated in response to axon guidance cues- do different guidance cues elicit dynamic changes in different sets of proteins- how do these proteins control the chemotactic turning behaviour of a growth coneThe present proposal addresses these questions using a comparative proteomic app roach involving C-terminal puromycyl-tagging of newly synthesized proteins in developing chick retinal growth cones. Once identified, the function of the cue-induced nascent protein(s), will be approached using gene manipulations and protein knock-down experiments in vitro and in vivo in the Xenopus retinotectal system.Prof. Holts laboratory provides an excellent environment to study all of these aspects of axon guidance both in vitro and in vivo. Moreover, moving to the host institute will complement my scientific training and is essential to achieve my goal of becoming an independent researcher in neurobiology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Many Kinds of Many: Pluralism about Properties', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In both ordinary and scientific inquiry we often seem to attribute properties to things, or to kinds of things: we say, for example, that grass is green, that the earth is spherical, that humans are animals, and that murder is wrong. We also seem to think that these properties are things in their own right: there is something that it is to be green, or spherical, or an animal, or wrong, and that scientific or normative projects are engaged in uncovering the essences of such properties.If we take these initial thoughts to amount to anything, an important question arises: what kind of things should we take properties to be? Perhaps we should take them to be those things in virtue of which one kind of thing is demarcated from another kind of thing. Or perhaps as those aspects of an object which ground the causal powers of that object. Alternatively, perhaps we should take properties to be just those things that are referred to by our predicates.These suggestions are all brief expressions of different ways of understanding properties, ranging from the thought that properties should only be those things that ground some genuine similarities between objects, thus rendering properties relatively sparse, to the thought that any predicate with consistent rules for its application can give rise to a corresponding property, thus rendering properties abundant.This project outlines and argues for pluralism about properties. It argues that we should take the existence of properties seriously, and aims to give a fully developed inventory of the various kinds of properties we should posit, why we should posit them, and what jobs each kind of property can do. It also aims to show why adopting a pluralist conception of properties over a monist conception of properties – which claims that
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'SUpeR REsolution Adaptive LIght Sheet Microscopy for high resolution volumetric imaging in turbid specimen' under Seventh Framework.

assistant: **Concept**

Rapid high contrast imaging in combination with low light exposure makes light sheet microscopy particularly attractive for studying the three-dimensional development of biological specimens. Currently however, the highest resolution of light sheet microscopy can only be achieved with relatively transparent samples. To study more advanced stages of development, of particular interest in brain imaging, scattering and aberrations pose a significant obstacle to achieve super-resolution or even diffraction limited resolution. Adaptive optics can correct aberrations in situ, yet inhomogeneities in the sample can severely restrict the usable field-of-view. Here we propose the use of structured illumination with variable periodicity to reclaim the resolution for a wide field-of-view. This Marie Curie Fellowship will thus enable super-resolution light sheet imaging deep within turbid biological tissue.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Support to the Vice-Presidents of the ERC Scientific Council 2021-2022' to be submitted under Horizon Europe.

assistant: **Abstract**

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees the ERC's scientific management and the implementation of its Work Programme. This project aims to support the ERC Vice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2021 and 2022. This project will provide local administrative and advisory support to the three ERC Vice-Presidents. The staff supported by this project will provide analysis of the output of the ERC and the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment. The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process. The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under H
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European radar ocean sensing' (1994-1998).

assistant: **Innovation**

In the perspective of the Global Ocean Observing System (GOOS), the Services and the Coastal modules, an important goal is to develop operational tools for those in charge of safety and regulation for coastal marine operations and constructions, as well as for the protection of the marine environment. The ongoing planning of the GOOS Coastal Module already recognises the need to consider such actors as 'strategic partners' for the development of GOOS. The World Meteorological Organisation (WMO) has a global subgroup on ground based radars in ocean sensing (ROSE), bringing together different relevant activities in Europe, Australia, USA, and Japan. Together with the Intergovernmental Oceanographic Commission (IOC), WMO conducts several global programs for monitoring and predicting the ocean environment. Among such actors we find Vessel Traffic Services (VTS) operators, harbour management, coastal and waterway management and marine environmental protection organizations. These actors, in the following we use VTS as an example, are in a rapid development process due to general increase in traffic density and the new loads of environmental protection duties, and they feel the urge for more efficient tools. VTS, like other management tools, is an integrated concept embracing vessel and cargo data, seafloor, safety and rescue undertakings, and, in the context of the present proposal the governing met-ocean conditions (winds, waves, water level and currents) which affect the safety and manoeuvrability of ships, operational performances etc. Further, the requirement for such information is not limited to the actual location of interest, but needed for a fairly extensive area surrounding the focus points. This is due to the existence of strong spatial variability within the area
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Translational research in human epilepsies' (TRHE) under Seventh Framework.

assistant: **Objectives**

The goal of this proposal is to identify the major genes and gene variants that cause human epilepsies and their comorbid traits of cognitive and behavioral impairments. The common epilepsies are complex disorders caused by a combination of susceptibility genes. To date we have identified major genes for three main classes of epilepsy that account for 30% of the population total. In this proposal we aim to (1) Search for sequence and structural variations in identified genes ELP4, BRD2 and ME2 that predispose to disease; (2) Repeat genomewide screens and fine-mapping studies for additional susceptibility loci that act in combination with identified genes; (3) Develop animal models to delineate functional effects of gene variants. The significance of this proposal is manifold. First, trait susceptibility genes discovered through study of epilepsies may contribute to common neurodevelopmental impairments in the general population, eg for reading disability. Second, genes for common epilepsies may be shared with less common but more catastrophic neuroregressive conditions. Third, our discoveries will also significantly contribute to our understanding of the mechanisms of normal and abnormal postnatal brain development. Last, we anticipate that genetic discoveries will lead to better diagnostic screening tests, prediction of risk in presymptomatic individuals, and gene-based therapeutic strategies that not only avoid the adverse effect profiles of the current generation of antiepileptic agents but also may result in cure and prevention.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MicroRNA in development and progression of prostate cancer' under Sixth Framework.

assistant: **Concept**

In Europe, around 80 cases of prostate cancer per 100,000 population diagnosed each year. However, very little is known about the molecular mechanisms behind this disease. A fundamental dilemma is the difficulty in identifying clinically important cancers, while they are confined to the prostate gland.Conversely, it is important to identify clinically unimportant cancers so that patients can be spared aggressive treatment. Enhanced understanding of the molecular basis of development of this disease is sorely needed in order to enhance the treatment options and to develop more sensitive and specific prostate cancer diagnostic and prognostic tools.MicroRNA (miRNA) are small non-coding RNA that control gene expression by effectively preventing mRNAs from being translated. The miRNAs play an important role in development and cellular processes such as differentiation, cell growth, cell death and stem cell division, all of which closely linked to cancer.It has been shown that miRNA are aberrantly expressed in several forms of cancer e.g. leukaemia, colon, breast, and lung. Preliminary studies have indicated that the levels of certain miRNAs are altered in prostate cancer. In the proposed study archived tissue samples of prostate tumours and normal tissue will b e used to isolate miRNA that due to their short length are basically unaffected by the harsh fixation and embidding processes these samples have gone through.Differentially displayed miRNAs will be identified using qRT-PCR and confirmed with in situ hybridisation onto tissue microarrays. The biological relevance of the miRNA is confirmed in vitro by introducing anti-miRNA probes, and predicted miRNA targets confirmed.Further, the miRNAs potential in diagnostic use miRNA will be determined on serum samples from prostat