RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding and Boosting Motivation using Brain Stimulation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Imagine losing the motivation to do the job that you used to enjoy. The idea of doing those tasks overwhelms you. You cannot push yourself to give the best efforts and end up doing the bare minimum. What are the brain processes that cause such depleted motivation and how can we restore the motivation to put in effort in order to achieve goals? To address these questions, I propose a series of studies to gain a theoretical and practical understanding of the causal relationship between brain computations of effort and the motivation to energise behavior to achieve goals. Specifically I plan to conduct, for the first time, a combined brain stimulation-functional neuroimaging (Transcranial Magnetic Stimulation-TMS; functional Magnetic Resonance Imaging-fMRI) experiment to perturb brain regions whose activity represents the amount of effort costs, and measure its impact on neural value computations in a remote but interconnected brain region known to drive choice behavior. This change in causal interplay in the brain should have a quantifiable impact on the motivation to expend effort. I will then use this theoretical knowledge to design a large-scale application of an inexpensive brain stimulation method (Transcranial Direct Current Stimulation-tDCS) to increase motivation, thus establishing a realistic and versatile protocol for restoring motivation in rehabilitative settings. In sum, my research will address the overarching question of how motivation can be enhanced with neuroscience techniques, by combining computational and neuroimaging advances in effort discounting with causal brain stimulation methods. This project will allow me to be trained in the two most common brain stimulation techniques at a pioneering lab in Europe, and forge a new collaborative research line
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Sustainable Polyesters and Renewable Terpenoid Monomers'.

assistant: **Concept**

Synthetic polymers derived from petrochemical products are essential for the production of a wide range of consumer products. The demand for more sustainable and renewable monomers and polymers is currently increasing, because fossil feedstock will become scarce in future times, and the global legislation is putting an increasing stress on the use of certain monomers used in the polymer industry. The aliphatic polyesters represent one of the most appealing type of bioplastic materials, because of their general biocompatibility and facile hydrolytic degradation and, in this ambit, the use of terpenes as monomers or monomer-precursors is largely unexplored. The primary objective of this project, is the creation of new polyester formulations based on renewable and accessible terpene monomers to answer to the growing need for future generations of more functional and sustainable materials. Three renewable monomers have been selected, two derived from camphor and a new one from β-elemene. Structurally new polyesters will be synthesized by ring opening (co)polymerization of these monomers, using catalytic systems based on cheap and health-friendly metals (Fe, Al). The use of the new β-elemene based monomer will incorporate vinylic groups along the polymer chains, offering the possibility for post-modification of the obtained material. The success of the project is supported by the Experienced Researcher background in polymer synthesis with the Host experience in the discovery and catalytic valorization of new terpene scaffolds. The action will take place in an interdisciplinary and international environment, granting to the Experienced Researcher a solid train in scientific and soft skills needed for his future career. The results of the action will have a strong impact on th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Expression and function of globin X in nucleated red blood cells of fish' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of the project is to understand the function of globin X (GbX) in the activation of the sodium/proton exchange across the erythrocyte membrane of fish. This exchange is oxygen dependent and activated by adrenergic stimulation; however the exact mechanism is unknown. It has been suggested that membrane binding of haemoglobin would be involved but such haemoglobin has not been found yet.Recently we found that GbX mRNA is expressed in red blood cells of fish. GbX is a membrane-bound vertebrate globin that is unique within the vertebrate (haemo-) globin superfamily and its cellular functions are not well understood because practically all available data on GbX are based on mRNA abundance.In a multidisciplinary approach we will combine the molecular and functional findings on GbX and oxygen-dependent membrane transport in a completely new fashion with an environmental focus. The study includes in vitro approaches in red blood cell culture and in vivo experiments in different fish species to unravel the cellular functions of GbX. The central research question is if GbX regulates the oxygen affinity of haemoglobin by affecting the ion transport in nucleated erythrocytes of fish.The research proposed in this proposal has the potential to make a valuable contribution to the field of red blood cell research by applying state-of-the-art techniques which have not been applied to nucleated erythrocytes before. The underlying aims are to explain the molecular basis of oxygen transport and to unravel adaptation mechanisms of fish species to environmental challenges. The project thereby touches several of the biggest issues today since global warming, oxygen limitation and pollution highly impact aquatic ecosystems worldwide. In particular marginal Seas such as the Baltic Sea,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optical Entanglement of Nuclear Spins in Silicon', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

A major breakthrough in quantum information processing is expected once “qubits”, carriers of quantum information, can be reliably integrated and controlled in silicon – the basis of today’s advanced classical information technology. Previous qubit realizations used the electronic spin of quantum dots or dopants, i.e. atoms of a different species replacing silicon in the lattice. However, this approach has only allowed for the entanglement of qubits in immediate proximity, which has hindered increasing the size of silicon-based quantum information processing systems. In OpENSpinS, these limitations will be overcome by using the nuclear spins of erbium dopants as qubits. These are initialized, read-out and controllably entangled using photons in the minimal-loss band of existing fiber-optical infrastructure. To demonstrate the unique potential of this approach, the specific objectives of the proposal are: I) The fabrication of nanophotonic resonators with unprecedented Purcell enhancement to enable coherent spin-photon coupling, II) the direct optical addressing and control of nuclear spin qubits with long coherence, and III) the implementation of optically-controlled two-qubit quantum gates and entanglement, both within a node and over distance. The proposed system combines the advantages of two leading platforms for quantum information processing: the bandwidth and long-distance connectivity of photons at telecommunications wavelength with the robust control and hour-long qubit storage achievable with nuclear spins in silicon. As the proposed chip-integrated resonators can be manufactured using established processes of the semiconductor industry, the novel hardware platform implemented in OpENSpinS offers unique prospects for future up-scaling of quantum information pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'DEMONSTRATION TRIALS OF DIVERLESS REPAIR TECHNIQUES FOR OFFSHORE INSTALLATIONS' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The aim was to demonstrate that strengthening and repair systems can be implemented using remote intervention in a safe, cost-effective and operationally practical manner. The primary objective was to conduct large scale in-water demonstration trials of selected structural strengthening and repair systems, using either a work-class remotely operated vehicle (WROV) or an atmospheric diving system (ADS) and including experimental assessment of the effectiveness of the implemented systems. The success of the project has proven the techniques necessary for repairs at dephts within and beyond diver access. Repairs were selected to enable most practical scenarios to be addressed.The project has been successfully executed and the objective has been met. A recommended set of designs and installation procedures have been created as principal deliverables. These have been fully developed through a three-level tier of functional, dry and in-water demonstration trials.A significant number of innovative designs were introduced to the strengthening and repair systems to make themWROV-friendly".WROV and NEWTSUIT ADS Performance :Significant and important lessons were learnt about the comparative performance of the two intervention systems. The trials highlighted the strenghts and weaknesses of each system. The appropriate configuration of the Wrov/ADS and understanding of their respective capabilities in the underwater environment were paramount to the development of successful systems and procedures.EXPERIMENTAL VERIFICATION :Structural failure tests were conducted on each of the strenghtening and repair systems installed during the inwater trials. The tests demonstrated that appropriate systems and procedures were used to achieve satisfactory repairs. In addition, the tests provided
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Thermosetting resin for Clean Sky', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Within the Clean Sky JTI, the use of a nanocomposite material for primary structures of a Green Regional Aircraft is going to be thoroughly studied and analysed. The nano-filler modified matrix have a great potential to exhibit high performance in terms of thermal, mechanical and electrical properties. The modified resins should able to be used in the prepreg route for composite fabrication, which means that the uncured resin must exhibits proper rheological properties and dispersion in liquid phase compatible with the impregnation of dry fiber fabrics. The objective of AIT is to manufacture nanomodified resins to fulfil the requirements of the Clean Sky roadmap. In a first step, nanoparticles will be selected among 1D (needle shape like carbon nanotubes or nanofibres), 2D (plate shape like nanoclays) and 3D (ball shape like Al2O3, ZrO2, or Boehmite) geometries. Then AIT will benefit of its experience in nanotechnology to set-up the dispersion methods, to produce batches of modified resin (12 different types are planed), to set up the curing parameter, to produce samples and finally, to characterize them. The proposed test campaign will investigate the chemical, physical, morphological, rheological, thermal, mechanical and electrical properties. The dissemination and exploitation of the result will be assure by the management Team in close communication and collaboration with the ITD leaders and other CS-RTD partners.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Identification and characterization of novel essential regulators of acute myeloid leukemia'.

assistant: **Innovation**

Acute myeloid leukemia is a hematopoietic malignancy characterized by the abnormal proliferation of immature myeloid cells. The implementation of high-throughput sequencing revealed that somatic mutations in various epigenetic regulators represent a frequent pathogenic phenomenon in leukemogenesis. This raised optimism for the development of new therapies in leukemia due to the reversible nature of epigenetic marks and amenability of chromatin-modifying enzymes to pharmacological inhibition. However, realization of this potential requires further research into epigenetic mechanisms governing the maintenance of leukemic cells. The overall goal of the proposed work is to characterize novel important epigenetic regulators in leukemic cells and to assess their potential as drug targets. Firstly, I plan to identify and study epigenetic regulators essential for leukemic cells deficient in TET2, an enzyme that hydroxylates methylated cytosines in DNA. This will be achieved by performing state-of-the-art shRNA screens in mouse Tet2-null leukemia models and by exploring the functions of the uncovered candidates using a range of cell biology, biochemistry, and functional genomics approaches. The second aim is to investigate the molecular functions of SETD5, a newly-uncovered epigenetic regulator of leukemic cells. This will be achieved by identifying its target genes and interacting partners in leukemic cells and by exploring the effects of its depletion on normal and cancer cells. The accomplishment of both research aims will provide new insights into epigenetic regulation of leukemic cells and highlight novel drug targets for future therapy development. The project will be supervised by Prof Kristian Helin, a world-leading expert in the field of epigenetics and cancer. Through
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Gene therapy: an integrated approach for neoplastic treatment', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Translation of genetic knowledge from the Human Genome into disease-specific therapy for untreatable congenital and acquired diseases is now reality. However, the gene therapy vectors currently used in experimental settings can be developed for safe clinical application only if fundamental problems are solved: ie the limitation of vector dose by attachment targeting and expression control and a decrease of non-specific toxicity. Minimisation of vector immunogenicity (stealthing) is necessary to reduce bloodstream and immune-mediated reduction of effective vector concentration. In the GIANT project, targeting and stealthing of both viral and non-viral vectors will be used to select candidates for testing in Phase I clinical studies. GIANT will concentrate firstly on one uniform model system and disease target (prostate carcinoma) for vector testing standardisation and in vitro, preclinical and clinical vector comparison. We will use a clinically approved vector backbone of adenoviral constructs re-targeted to prostate cancer via surface antigens, and hybrid prostate targeted promoters. The consortium includes a GMP vector production facility and clinical facilities with scientific and ethical permission to carry out human cytotoxic gene therapy trials, guaranteeing the immmediate translation of selected vectors into the clinical testing. The biomaterials obtained will serve to develop new assays for vector distribution, efficacy and monitoring of the immune response against various vector systems. The GIANT participants have a long record of EU-based scientific collaboration and expertise in ethically approved clinical vector generation. The SMEs own international patents on retargeting vectors and target discovery methods, providing a technology platform for further exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Exploration for Large Interacting Systems of Agents' (ELISA) under Horizon Europe.

assistant: **Objectives**

This ERC project addresses mathematical theories and numerical tools for mean-field models, which are used to describe the statistical state of a population. Mathematically, such models are often seen as time-dependent systems whose state variable takes values in a space of probability measures. One of the key features of the ERC project is its focus on mean field models for which the state of the population is itself random. Primarily, we aim to consider dynamics with values in the space of probability measures that are subject to an external noise, which is often called a common noise. Our main hypothesis may be formulated as follows: It is possible to construct a common noise that would force mean-field dynamics to explore the space of probability measures in an efficient manner, very much in the spirit of a Brownian motion in the Euclidean setting.  This hypothesis will be studied along the following three axes: 1) Exploration is used for forcing uniqueness and stability of solutions to Fokker-Planck and related McKean-Vlasov equations and also to mean-field models of rational agents like mean-field control problems or mean-field games; 2) Exploration is used for the numerical analysis and the statistical learning of mean-field models featuring some optimisation criteria; 3) Exploration can be subject to a more irregular noise than a Brownian motion in the spirit of rough path theory. Expected applications are in probability theory, partial differential equations, control and game theory, optimisation, mathematical modelling and numerical methods at the interface with machine learning.


**Keywords:** Mean field models,  Mean field control,  Mean field games,  Noise on the space of probability measures,  Measure-valued processes,  Wasserstein diffusion,  Gradient de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Comparing Constitutional Adjudication (Co.Co.A.): A Summer School on Comparative Interpretation of European Constitutional Jurisprudence'.

assistant: **Objectives**

The Summer School provides an opportunity for an intensive training of legal assistants to Constitutional Courts as well as of experienced researchers, Ph.D. candidates and graduate students. They will analyse comparatively different issues both in a theoretical perspective and with reference to specific decisions and legal reasoning by single Courts.Being based on the idea that the mutual interaction between the professional and the scientific competence is a highly valued resource, it is an investment not only in a constitutional adjudication per se of good quality but mostly in a constitutional adjudication sensitive to European harmonisation in terms of both comparative jurisprudence and of international/supranational law effectiveness.The latest generation of written Constitutions, adopted since 1989 in Central, Eastern and South-Eastern Europe, invariably includes judicial review of constitutionality and judicial protection of constitutional rights as a power attributed to a centralised Constitutional Court.The domestic catalogue of constitutional rights is integrated with reference to provisions of international law dealing with human rights, in particular the European Convention for the Protection of Human Rights and Fundamental Freedoms, an international instrument that had produced a remarkable case law by the European Court of Human Rights.National Constitutional Courts are to be playing a crucial role in shaping a living constitutional law from the point of view of the domestic Constitutions and of the complexities of competing international legal sources.The impact of specific legal provisions and of the case law by the European Court of the European Community in the area of fundamental rights is also worthy of attention at least for candidate member States