RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'IP ConferEncing with Broadband multimedia ovER Geostationary Satellites' (ICEBERGS).

assistant: **Concept**

Today there is an exponential growth of IP conversational traffic. Satellite networks can offer an optimal support to Multimedia Multiparty Conferencing and IP Multicasting Services over large geographical areas. The main objective of the project is to define on optimised network architecture and related performance for the provision of IP multicast multiparty multimedia conversational services over a Ka-band, OBP based broadband satellite infrastructure. Moreover the interworking between the satellite network and the IP-based multimedia multiparty conversational services will be designed and validated. A phased approach will be adopted; a study phase dealing with system and service requirement definition, system analysis and the satellite network design for QoS sensitive service; a demonstration phase dealing with the development of a Demonstrator Network Prototype, validation campaign execution and results analysis.Objectives:- The provision of business class and consumer IP based multiparty multimedia conversational services and broadband multicasting services to both fixed, and portable/mobile users, with guaranteed QoS, represents a challenge for next generation networks. It will be faced by studying optimal satellite routing techniques, end-to-end delay control mechanisms and specific service support functionality;- To demonstrate and qualify the service performance with an extensive trial campaign involving both satellite and an Internet segment upgraded to provide QoS support. The demonstrator envisages several satellite nodes, a service centre and a representative operation centre;- To contribute to standardisation activities proposing optimised solutions for protocols, interworking techniques and multicast routing in the frame of IETF and ETSI.Work description
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Low cots Advanced Driver Assistance Systems (ADAS): A cost affordable solution for improved road safety', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Road safety is a mayor societal issue with road accidents being main cause of death in industrial countries. According to theWorld Health Organization, the total number of road traffic deaths remains unacceptably high at 1.24 million per year,occupying the 9th position in the list of top leading causes of death in the world. Advanced driver assistance systems(ADAS) can contribute to a possible solution.ADAS are systems developed to automate, adapt and enhance vehicle systems for safety and better driving. Since 2000,the automotive industry has gradually introduced new ADAS features in vehicles. The progress in this field has beenenormous and it has been demonstrated that the most advanced ADAS systems can contribute reducing fatal roadaccidents by a factor of more than 30%. However, in spite of the huge progress so far, relatively few vehicles on the roadtoday have these systems, and their share of the market is growing at only 2 to 5 percent annually.The major problem preventing ADAS massive implementation is that these systems are only offered to the drivers whenpurchasing a new vehicle as embedded solutions and the most advanced (securest ADAS) are found only in the high pricevehicle segment. This implies that the improved driving safety is restricted to the high purchasing power consumers and onlywhen replacing their old car, while it is not accessible to the lower-middleclass consumers.The SMARTCARS project is aimed at making the most advanced ADAS systems accessible to everyone. Our technology isnot based on an embedded system but on an external hardware solution which can be integrated to any car manufacturedafter year 2000 by a simple USB connection. SMARTCARS will enable any car owner paying just 475€ and 30€/year forsystem maintenance, to enjoy the improved dr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integrative Analysis of Cellular Drivers of Color Diversification in Development and Evolution' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

During development, tissues are formed by the assembly of different cell types. Evolutionary changes in tissue phenotypes can be the result of mutations that alter the cell type composition or the cell types and their inherent properties. Although these are clear mechanistic links between development and evolution, most research has focused on the endpoints of the genotype-phenotype map, treating the cellular mechanisms that bridge genotype and phenotype as a black box. How changes in cell types contribute to the evolutionary change of tissues has been largely neglected, although it may be a key element driving phenotypic diversity. To study the role of cellular diversification in evolution, I will use a vertebrate system that has proven ideal for genotype-phenotype mapping: the species-rich and phenotypically diverse family of cichlid fishes. By focusing on a phenotypic trait (coloration) whose properties are directly linked to the cellular properties of a manageable number of pigment cell types, I will investigate the functional and mechanistic links that connect cellular changes to phenotypic changes arising during development (formation of distinct epithelial coloration traits) and evolution (formation of phenotypically diverse species). Using novel methodological approaches, I will phenotype cells in an integrative manner using a combination of single-cell RNA sequencing and high-throughput cellular phenotyping. The sufficiently (but not excessively) complex system of integumentary pigment cells is ideal for making concrete functional predictions about how cellular changes ultimately drive evolutionary change. This proposal will refine the concept of cell types and cellular variation in an evolutionary developmental context. It will pave the way for novel insights
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Examining Oscillatory Dynamics with Magnetoencephalography and Intracranial Electroencephalography' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The scientific goal of this project is to use magnetoencephalography (MEG) and intracerebral electroencephalography (iEEG) to gain a better understanding of subcortical and abnormal cortical oscillatory dynamics. The first specific aim of this project is to apply the most sophisticated techniques currently available to resolve the activity of deep brain structures, such as the amygdala, hippocampus, brainstem, and cerebellum, using noninvasive MEG recordings. Time-frequency analysis may be better suited to the nature of the signals produced by these structures than traditional event-related averages. Therefore, advanced spatial filtering techniques will be combined with time-frequency analysis to produce five-dimensional space-time-frequency maps of brain activity. A realistic head model will be used in the construction of the spatial filters, enhancing the spatial resolution of deeper sources. The results will be validated and augmented with iEEG recordings from intractable epilepsy patients who receive clinically indicated depth electrode implants in these areas. Additionally, time-frequency analysis will be applied to EEG-based auditory brainstem response (ABR) recordings to investigate its utility compared to the thousands-of-trials average currently in clinical practice.      The second specific aim is to examine the abnormal spontaneous oscillatory activity associated with tinnitus. Recent studies suggest that the phantom perception of many tinnitus patients arise from abnormal synchronization of auditory cortex. However,  to date, most efforts in EEG/MEG source localization have concentrated on the localization of high-amplitude transient epileptic spikes or stimulus-evoked experimental designs. These methods require further technical development to allow the ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'CERTIFIED PACKS FOR EASIER NEXT-GENERATION SEQUENCING CLINICAL DIAGNOSTICS' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Next-generation sequencing (NGS) has revolutionized genomic research by drastically decreasing the cost of sequencing and increasing the throughput of generated data, but still has not been able to reach its implementation in clinical diagnostic laboratories where there is a huge potential market application for it. The current market gold-standard in clinical diagnostic (i.e. Sanger-based sequencing) is outdated, much less efficient and more expensive than NGS, but no current market solutions have yet been able to properly address the complexity involved in transferring and validating gold-standard procedures to NGS platforms in clinical environment. In fact, current competing solutions are disruptive, complex, non-efficient and non-validated to address the challenges of transferring NGS to clinics. The easierNGS business concept aims to create and offer an innovative package of services and products which combined will allow a fast, cost-effective, streamlined and certified full sample-to-result solution to clinical laboratories that wish to seize the tremendous benefits of the new NGS era. Towards this objective, a feasibility assessment of the easierNGS business concept will be conducted to better determine its technical, economic and legal viability, as well as plan its most appropriate operational and scheduling strategy. Three case studies (i.e. NGS panels for pharmacogenomics, neonatal screening and infertility risk factors) will be used to generate a proof-of-concept of the easierNGS and help define the technical aspects and guidelines for future easierNGS packages and support a conscientious “Go/No go” decision towards a real market assessment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Strategic Research Roadmap for European Web Security' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The Web platform is a hotbed of innovation that will affect deployment of technologies and applications for the next decade, and will influence the security and privacy that European users and service providers can achieve.<br/>The STREWS project will link European security and trust related research and devel- opment with ongoing standards and development work for the Web in IETF and W3C. The project will develop a technical state of practice document for Web Security as a basis for case studies on selected Web security topics. A roadmap for future research and standardization in the Web security field will provide guidance for ongoing and future research. Over the course of the project, STREWS will reach out to European industry and projects, and organize a series of workshops to collect broad input into its roadmapping and case study work, and to create a European Web security community across academia and practice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'From understanding to rational design of next-generation cancer therapies' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Immunotherapy combined with cytotoxic and molecular therapies have entered centre stage as novel treatments for cancer. Despite this advance, toxicity and insufficient efficacy in many patients remain major obstacles and illustrate the need for therapy improvement based on a deeper understanding of the cellular damage and repair responses to drugs and immunotherapy. To overcome this roadblock, I propose a previously unappreciated approach by combining immunotherapy with cancer therapies at ultra-low, sublethal dose. We demonstrated that cytotoxic T cells induce sublethal membrane and DNA damage and oxidative stress which, when repaired, allows for tumor cell survival. However, when damage adds up, the tumor cell dies.I hypothesize that sublethal effects reveal novel vulnerabilities in cancer cells which can be exploited by complementary multi-targeted therapies at ultra-low dose which are nontoxic individually but, when combined, achieve lethality by an additive mechanism.Taking advantage of innovative microscopy, I aim to produce a catalogue of damages and repair types, and their combined effects in tumor cells. Single-cell analyses combined with advanced statistics and mathematical modeling will be used to derive the damage profile and duration of damage for each modality in tumor cells, yet without side effects towards immune effector cells. I will design algorithms for multi-targeted regimens to achieve additive damage, reduced repair, and death induction and validate them in immunotherapy models in vitro and in local and disseminated preclinical cancer in vivo. If resistance occurs, survival programs will be detected by single-cell transcriptomics and countered by orthogonal targeting.subLETHAL will 1) identify sublethal damage as the basis of cytotoxic therapy, 2)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Advancing reaction kinetics of Oxidative Coupling of Methane by operando spatiotemporal reactor analysis'.

assistant: **Objectives**

Abundant availability of methane makes this compound being a potential substitute to crude oil for ethylene production if such chemical conversion is feasible. The direct transformation of methane into olefins via Oxidative Coupling of Methane (OCM) is nowadays still considered as a “dream” reaction for the direct production of ethylene from methane. This process remains a huge challenge in chemical engineering research. A better understanding on how the reaction proceeds in space and time in the reactor (mechanism and kinetics of the process) and the development of advanced efficient catalysts are crucial steps to achieve the industrial implementation of the process. The traditional methodology to evaluate catalytic performance and addressing kinetic analyses, which consists on the assumption of a constant temperature for the catalytic bed and the evaluation of the gas composition at the reactor outlet, seems not to be a suitable strategy for chemical processes such as OCM. KinGrad-OCM aims to set up a new methodological approach based on the application of operando spatial reactor analysis techniques for the study of the OCM reaction both in conventional furnace heated and microwave-assisted reactors. A particular focus is given to the assessment of reaction kinetic by the operando spatial reactor analysis through the physicochemical gradients present in the reactors. The successful application of the gradient approach, proposed in KinGrad-OCM, for assessing kinetic studies will yield a new perspective to both catalyst and reactor design not only for the OCM process but also for other complex chemical reactions.


**Keywords:** Oxidative coupling of methane, reaction kinetics, operando spatiotemporal reactor analyses, operando spectroscopy, microwave-assisted reactor,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flashing liquids in industrial environments (FLIE)' under Fifth Framework.

assistant: **Concept**

The project aim to improve the understanding of the processes that occur in accidental flashing releases of liquids at high pressure, and to enhance the predictive capabilities of engineering tools used in hazard assessment. Flammable atmospheres contain on the order of 5-10% (hydro-carbon) gas. Such concentrations are only possible close the release. Detailed understanding of the source is required in order to obtain reliable predictions of the hazardous region. The project comprises four activities: Lab-scale experiments to improve knowledge about the release processes. The formulation of mathematical/physical models based on data from the experiments. Algorithms developed to implement the mathematical description into robust, efficient and correct simulation models. Finally, design and execution of large scale experiments to provide validation data for the developed models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Retargeted Pyocins: A novel tool for combating major food borne pathogens and exploiting phage-host interactions' to be submitted under Horizon 2020.

assistant: **Abstract**

Campylobacter jejuni and Salmonella serovars are the major foodborne pathogen burden of Europe, imposing economic costs and challenging treatment of human infections due to increasing antimicrobial resistance. Hence, the EU commission stresses an urgent need to develop new effective antimicrobials. Exploiting natural predators of bacteria (phages) or phage-derived products may be a source of such novel antimicrobials. But lack of genetic approaches to investigate phage binding mediated by receptor binding proteins (RBPs) hampers progress of phage therapeutics targeting C. jejuni and Salmonella. Thus, goals are to i) discover RBPs of phages infecting C. jejuni and Salmonella serovars using pyocins as a novel advanced tool, and ii) develop novel phage-derived therapeutics with high bactericidal activity targeted to C. jejuni and the most prevalent Salmonella serovars. Putative RBPs will be identified from phage sequences by exploring knowledge of phage receptors and similarity of RBPs among phages binding identical receptors. By creating RBP fused-pyocins, potent killing activity of retargeted pyocins will be used to demonstrate binding specificities of RBPs to C. jejuni and Salmonella. Mutational analysis will identify key amino acids responsible for RBP binding, which also will be modified to modulate the specificity of the retargeted pyocins, developing an arsenal of novel antimicrobials targeting distinct or diverse C. jejuni and Salmonella serovars. On completion of this fellowship, I will complement my veterinary-microbiology background with bioinformatics and molecular skills including cloning, expression, purification, and structural analysis of proteins, allowing me to develop novel interdisciplinary projects exploring phage-derived proteins for human benefit. I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structure function and pharmacology of calcium-activated chloride channels: Anoctamins and Bestrophins', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Calcium-activated chloride channels (CaCCs) play key roles in a range of physiological processes such as the control of membrane excitability, photoreception and epithelial secretion. Although the importance of these channels has been recognized for more than 30 years their molecular identity remained obscure. The recent discovery of two protein families encoding for CaCCs, Anoctamins and Bestrophins, was a scientific breakthrough that has provided first insight into two novel ion channel architectures. Within this proposal we aim to determine the first high resolution structures of members of both families and study their functional behavior by an interdisciplinary approach combining biochemistry, X-ray crystallography and electrophysiology. The structural investigation of eukaryotic membrane proteins is extremely challenging and will require us to investigate large numbers of candidates to single out family members with superior biochemical properties. During the last year we have made large progress in this direction. By screening numerous eukaryotic Anoctamins and prokaryotic Bestrophins we have identified well-behaved proteins for both families, which were successfully scaled-up and purified. Additional family members will be identified within the course of the project. For these stable proteins we plan to grow crystals diffracting to high resolution and to proceed with structure determination. With first structural information in hand we will perform detailed functional studies using electrophysiology and complementary biophysical techniques to gain mechanistic insight into ion permeation and gating. As the pharmacology of both families is still in its infancy we will in later stages also engage in the identification and characterization of inhibitors and activato