RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CTCF control of genome stability in ageing' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

.   Genome stability is one of the most important features in maintaining tissue homeostasis throughout the human lifespan. The research presented here will dissect how the insulator protein CCCTC-binding factor (CTCF), a ubiquitous 11 zinc finger transcription factor, controls the stability of the mammalian genome during ageing..   In Aim 1, we will elucidate how CTCF and tissue-specific master regulators maintain the functional stability of the genome during healthy ageing by developing a novel protocol to map simultaneously transcription and open chromatin in isolated hepatocyte nuclei. Using this protocol, we will explore how CTCF binding stabilizes cellular homeostasis during ageing by knocking down CTCF in vivo, both in isolation and simultaneously with knock down of liver-specific master regulators..   In Aim 2, we will reveal the molecular mechanisms underlying CTCF binding sites as susceptibility loci for somatic mutations. We will profile the mutations in open chromatin of single nuclei immediately following acute exposure to a chemical mutagen; comparing how the pattern of mutations in CTCF bound regions changes across an allelic series of CTCF knockdown mice will reveal how CTCF binding shapes the stability of the genome towards mutations..   These integrated strategies develop and deploy powerful, cutting-edge experimental approaches to reveal novel aspects of how CTCF binding stabilises the mammalian genome during healthy ageing as well as during mutagenesis.


**Keywords:** Ageing, Evolution, Insulator, Transcription, Epigenetics, Genome regulation, Mutagenesis, Regulatory networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Connected headset adapting music to emotions' (ONTBO).

assistant: **Concept**

This project aims to contribute to individual well-being by offering a device that adapts music to the user's emotions. ONTBO is a software coupled with neurotechnology that detects, interprets and adapts audio content to human emotions in real time. ONTBO measures the emotional state in real time (concentration, stress, relaxation) thanks to a connected headset with an electroencephalogram. The various AIs will then deliver the appropriate playlists to enable the user to reach the desired emotional state.


**Keywords:** neurotechnology AI music
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Secure and Wireless Multimodal Biometric Scanning Device for Passenger Verification Targeting Land and Sea Border Control' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Every year a large number of visitors enter the European Union (EU) by cars, buses, trains or ships through land-border crossing points or sea ports bringing significant economic benefits; in particular, 9% of Europe’s GDP comes from tourism. This trend is set to continue, as Europe further considers visa liberalization agreements in a bid to sustain their competitive stance in the global tourism market. This will create major implications on the security and border management in the EU, as well as diminishing the Quality of Experience for passenger travel.  Existing directives for controlling border crossing is to conduct checks using biometric data in conjunction with VIS (Visa Information Systems), as specified in the Schengen Border Code. However, current biometric systems rely on one mode of biometric data, that can at times can lead to false identification, in particular under uncontrolled conditions during live sample acquisition. Moreover, the current crop of scanning devices are limited in coverage and typically have fixed links, thus confining the range of border control applications and compromising the comfort of passengers. We aim to go beyond and propose an innovative passenger-centric biometric system that authenticates “on the fly”. We combine the scientific field of wireless security, biometric recognition and data fusion to develop a  secure and wireless multimodal biometric scanning device for passenger verification targeting land and sea border control applications. The research approach is the basis for a RISE training action that we refer to as eBORDER, that is foreseen to enhance both the career potential of staff members and innovation capacity at the institutional level. In this context, this action brings together key players from industry and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Cyclone gasification of pulverized biomass for operation of gas turbines in cogeneration plants'.

assistant: **Concept**

Project objectives The objective of the project is to develop a basis for design of cyclone gasifiers to be used in a novel way for gas turbine cogeneration plants fuelled with powdered biomass. It is expected that the process to be studied will make it possible to reduce the investment required for building wood fuelled cogeneration plants in the capacity range 100 kW(e) to about 20 MW(e). An important objective is to find out which of three suggested cyclone designs is preferable and which of four fuels is the most suitable. Technical approach  In the process that will be studied, the biomass is rapidly gasified in a pressurised cyclone, leaving a char residue with a significant portion of the sodium and potassium brought with the biomass fuel. The hot product gas is burned in an adapted combustion chamber without further gas cleaning. The hypothesis is that if the gasifier is operated under the right conditions, the Na- and K-compounds which do enter the gas turbine will have a melting temperature above 800 - 100K, i.e. above the material temperature of industrial gas turbines designed for moderate inlet temperatures. The char residue obtained from the cyclone gasifier can be used as fuel for a supplementary fired heat recovery boiler and will not be wasted. Both theoretical and experimental work will be required to increase the understanding of factors effecting the operational performance of gasification cyclones. Key problems to be studied are : a) The controlled feeding of the powder into the cyclone; b) Optimisation of cyclone design with respect to separation of Na- and K-compounds; c) Adaptation of gas turbine combustors for burning of the product gas from the cyclone gasifier; d) Dynamic behaviour of the system and; e) Deposition of Na- and K-compounds in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Strengthening Understanding and Strategies of business To Assess and Integrate Nature' (SUSTAIN).

assistant: **Concept**

Our global economy is intrinsically dependent on nature, and at the same time is playing a major role in its degradation. Recognition of this fact has grown substantially in the past decade, as evidenced in the EU Biodiversity strategy for 2030. However, transformative, system-wide changes are still needed to achieve the nature-positive outcomes required to 'bend the curve' of biodiversity loss. While the business case for economic actors to address biodiversity is becoming clearer in some sectors, it is still lacking in others, particularly those more removed from direct interactions with nature. SUSTAIN (Strengthening Understanding and Strategies of business To Assess and Integrate Nature) will bring together a multi-stakeholder and multi-disciplinary team to strengthen understanding and awareness of how all economic activities depend and impact on biodiversity. The project will build on existing work within the business and biodiversity space to develop and validate a database of business dependencies and impacts, develop methods that actors can use to reduce biodiversity-related risks, and a toolbox to support their application. The consortium will drive uptake of these resources through dissemination of targeted business case materials, drawing on existing networks and expertise in communicating with businesses, financial institutions and other key stakeholders.


**Keywords:** biodiversity, ecosystem services, private sector, measurement, monitoring, reporting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neo-Ottomanism? New Strategies of Turkey and the Impact of Foreign Aid to Post-War Cultural Reconstruction in the Balkans' (NeOtStraTurkBalk), addressing dissemination and exploitation.

assistant: **Impact**

This project seeks to find out how foreign assistance in the fields of culture, religious revival and education change regions ravaged by inter-ethnic violence and state breakdown, and how such foreign assistance is perceived locally. My case study is the assistance provided from the Turkish Republic to Bosnia-Herzegovina, and local responses to it. The empirical research will focus on Turkish aid in the areas of higher education, religious studies, and the rebuilding of Ottoman-era monuments. This project sets the analysis of the impact of Turkish aid in the Balkans in the context of the revival of the concept and debates on Neo-Ottomanism in the region and globally. The analysis poses following questions: How do the interpretations of the historical legacy of the Ottoman Empire in the post-Yugoslav region correspond with actual policies of aid that the Republic of Turkey provides as a major donor, especially for post-war reconstruction projects in Bosnia-Herzegovina? What sort of changes in the political and popular culture in the beneficiary country can we observe as a result of Turkish aid in the areas of culture, higher education and religious education, according to local responses in Bosnia-Herzegovina? What is the interaction between the fears of Neo-Ottomanism as an alleged expansionist and ‘Islamization’ program of Turkey in the Balkans and the anti-Turkish, anti-Muslim discourses as a recent characteristic of the populist rhetoric in several European Union states?
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Microfluidic-assisted fabrication of artifical microniches for bone marrow stem cells' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

There is a growing interest in adult stem cells, especially from bone marrow, for regenerative medicine. Hematopoietic stem cells, a type of bone marrow stem cells, alone cannot be expanded in vitro; in vivo, they reside in a microenvironment known as a niche that maintains them in a quiescent state until prompted to differentiate. The stem cell niche provides structural and trophic support and the appropriate homeostasis to regulate stem cell function. Additionally to regulatory factors in these stem cell niches, a number of environmental and mechanical signals arising from the extracellular matrix are crucial regulators of stem cell fate. In order to expedite for basic studies of bone marrow stem cells, and further translational implementation, any realistic approach to the native stem cell niche requires: to engineer a biomimetic 3D-microenvironment, and then to develop artificial microniches with the key functional features reconstructed. High-throughput microfluidic technology offers high promise, however, adaptation to accommodate adult stem cells in artificially fabricated niches remains still a challenge. Microfluidic-assisted culture systems should not only allow maintaining cell homeostasis through biochemical and mechanical stimulation, but also modulating adult stem cell renewal and differentiation through microscale patterning of cells and extracellular materials in biomimetic microniches. This project aims at the microfluidic reconstruction of an artificial stem cell niches. In this proof-of-concept, a bone marrow stem cell microniche with tunable size, material and topography will be developed by integrating novel fabrication microfluidics  with material engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Boosting Ethionamide efficacy and lowering the dose with a small molecule transcriptional modulators, to overcoming MDR-TB infections and define a new place for Ethionamide in 1st-line TB treatments.' (TRIC-TB).

assistant: **Concept**

Tuberculosis (TB) is the world’s leading infectious disease. It killed 1.7 million people in 2016 and 10.4 million people developed active TB in the same year. In 2016, 480’000 of TB cases were multidrug-resistant (MDR-TB) and 9% percent of those cases are extensively drug-resistant (XDR), with mortality rates as high as 70%. Ethionamide (ETH) is a vital part of the WHO essential medicines list of 2nd-line TB therapy for MDR-TB, however, ETH suffers from significant levels of resistance and side effects at current dosing levels. BVL-GSK038 and BVL-GSK098 are proprietary to BioVersys/GlaxoSmithKline and have been developed through an extensive Lead Optimization program with collaborators from Lille University. Low doses of both compounds fully restore and “boost” the activity of ETH to rapidly kill Mycobacterium tuberculosis (Mtb) including MDR strains at significantly lower doses of ETH than previously reported, thus making MDR-TB sensitive to ETH once again. Through a comprehensive IND enabling package including in vitro and in vivo assessment of ETH with BVL-GSK038 and BVL-GSK098, including PK/PD, resistance development, safety, mechanism of action and synergistic studies with different drug compound combinations and then first in human clinical studies the consortium aims to:      i) Define the future placement of a boosted ETH (ETH + BVL-GSK038 or BVL-GSK098) in a universal TB treatment regimen, including overcoming MDR-TB with improved safety, time to cure and relapse rates;Ultimately, we expect to identify a new and clinically proven TB regimen that leads to better patient outcomes independently of the starting resistance status of the TB infection. The TB and wider scientific communities will benefit from an improved understanding of ETH and the exploration of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Mathematics for Shape Memory Technologies in Biomechanics'.

assistant: **Concept**

Shape Memory Alloys (SMAs) are nowadays widely exploited for the realization of innovative devices and have a great impact on the development of a variety of biomedical applications ranging from orthodontic archwires to vascular stents. The design, realization, and optimization of such devices are quite demanding tasks. Mathematics is involved in this process as a major tool in order to let the modeling more accurate, the numerical simulations more reliable, and the design more effective. Many material properties of SMAs such as martensitic reorientation, training, and ferromagnetic behavior, are still to be properly and efficiently addressed. Therefore, new modeling ideas, along with original analytical and numerical techniques, are required. This project is aimed at addressing novel mathematical issues in order to move from experimental materials results toward the solution of real-scale biomechanical Engineering problems. The research focus will be multidisciplinary and include modeling, analytic, numerical, and computational issues. A progress in the macroscopic description of SMAs, the computational simulation of real-scale SMA devices, and the optimization of the production processes will contribute to advance in the direction of innovative applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Potentials of interdisciplinary degree courses in engineering, information technology, natural and socio-economics sciences in a changing society', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The need to address the under representation of women in the study and practice of engineering is the motivation for this proposal. The role interdisciplinary degree courses could play in the retention of women students and their progression to the labour market are examined, as is the acceptance of graduates from such degree courses in the work spheres. It is proposed to identify elements suitable for a methodology tool-box for future cross cultural equivalent comparative and empirical research By means of information gathering, discussions and expert interviews, a set of good-practice and suitable policy issues will be identified to form part recommendations emanating at the end of this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The effects of environmental change on mycorrhizal communities' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The response of different mycorrhizal fungi (individually and in combinations) to aspects of environmental change will be determined under controlled conditions. Predictions from growth room experiments will then be tested at established long term experimental field sites.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Soil conservation and protection strategies for europe' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

SCAPE is a concerted action that will give support to the development of a European strategy on soil protection and conservation. This will be based on the multi-functionality of the soil.It will do this by holding four workshops and a conference that address key questions concerning:a) how can the goals of sustainability be achieved;b) what is the appropriate data and monitoring strategy for Europe and what can we learn from best practise. It will support the development of a research agenda for the next decade, guidelines for managing and protecting soil functions, advice on about best practise and proposals for measurement and monitoring.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Promoting and Improving Azerbaijan Research Collaboration with European Research Area' to be submitted under Seventh Framework.

assistant: **Abstract**

The PRIMA-ERA project is designed to reinforce research collaboration between the Institute of Physics, Azerbaijan National Academy of Sciences (IPA) and research centres in the European Research Area. The IPA is a leading organization on scientific research, knowledge transfer and graduate education in physics in Azerbaijan. PRIMA-ERA will facilitate the collaboration of the IPA with research centres in EU member and associate countries and reinforce its engagement in the FP7 projects in research topics covered by such thematic priorities as energy and nanotechnologies.The primary objectives of the project are:-to increase IPA capacities and preparedness for collaboration in the FP7 through twinning and networking, development of joint research plans and training modules and trainings;-to increase visibility of IPA for international scientific community and other stakeholders through dissemination of scientific information and promotional activities;-to ensure the compliance of the IPA’s research activities with socio-economic needs of the country and regionally and provide better career opportunities for young scientists through encouragement innovative approaches and development of research strategy.The project consortium between the IPA, CNRS Institut de Recherche et Development sur l’Energie Photovoltaique, CNRS-IRDEP (France) and TUBITAK – Marmara Research Centre, TUBITAK - MAM (Turkey), has been established to effectively fulfill the project’s objectives.The PRIMA-ERA will comply with the EU strategies for an “open ERA” as mentioned in the EC Communication for International S&T Cooperation by providing mobility and access to research facilities between the centres with similar research interests. The project actions will be in coherence with the concept of the “m