RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Uncovering the effects of pharmaceuticals in the wild, beyond individuals to animal communities' (AquaDrugs) under Horizon Europe.

assistant: **Objectives**

The increasing production and release of pharmaceutical pollutants into waterways is now a leading threat to aquatic wildlife and ecosystems around the world. Despite this, knowledge on the hazards these contaminants cause in complex natural ecosystems is still extremely poor and thus considered an urgent research priority. AquaDrugs will harness new developments in underwater animal tracking and computer automation to identify how pharmaceutical waste in the environment can induce behavioural changes in animals that lead to high-order ecological effects.  Through a series of well-integrated experiments, and using fish as a model system, AquaDrugs will trace the impact of pharmaceuticals across biological scales to address four novel and ambitious objectives: (1) test how environmentally relevant concentrations of two globally pervasive pharmaceuticals (clobazam an tramadol), both in isolation and in a mixture, influence ecologically important wildlife behaviours and variability; (2) identify whether, and how, such changes impact animal collectives; (3) determine how pharmaceutical-induced behavioural changes at the individual and group levels scale up to shape aquatic communities; and (4) uncover how exposure shapes the ecological interactions of multiple species. The project will deliver urgently needed data for chemicals regulation leading to improved policies that safeguard Europes aquatic ecosystems and wildlife from pharmaceutical impacts. The interdisciplinary approaches and theory in AquaDrugsfrom integrative ecology, ecotoxicology, and analytical chemistryalso promises to yield pioneering results and experimental innovations that will advance these scientific fields and boost the expertise and academic career of the research fellow, Dr Marcus Michelangeli. Impo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Point of Care Diagnostic Test for the Differential Diagnosis of Inflammatory Bowel Disease'.

assistant: **Innovation**

Inflammatory bowel disease (IBD) is an umbrella term referring to two hard to diagnose chronic intestinal diseases: ulcerative colitis (UC) and Crohn's disease (CD). IBD is a relapsing condition and diagnosis can be missed if tests are carried out during remission. Thus, the diagnosis of IBD relies on a combination of different tests over a long period. However, for half the patients this results in late diagnosis, a major drawback since often the optimal treatment and management is already affected. Furthermore, IBD diagnosis using current tools (1) can be uncomfortable for patients, (2) carry significant risks including gastrointestinal perforation, and (3) in terms of monetary cost are expensive. Thus, in recent years researchers have been investigating the role of the gut microbiome in IBD, hoping to identify trademark features that could speed up diagnosis and combat the increasing prevalence of IBD in western socities. However, until now the use of this approach has been limited in the field of routine clinical diagnostics due to several limitations. After years of R&D, IPDx has overcome these concerns and introduces IBDetect: the world´s first single test for the differential detection of IBD. It can be used discriminate between the two different types of IBD from a very early, pre-symptomatic stage. All of this can be done in a minimally invasive, cost- and time-effective way with remarkable accuracy. IBDetect can be used to decrease the mean time to diagnosis in UC and CD as well as benefit the optimal treatment and management of these diseases. Our primary target group include gastroenterologists in European hospitals and medical centres in the US. We address the global in vitro diagnostics market in which the IBD-related gastrointestinal diagnostics segment i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Energy-efficient Computing via Reversibility' under Horizon Europe.

assistant: **Concept**

Energy is a main concern in current society as limited natural resources and high production costs lead to energy shortages, and energy consumption causes complex and undesirable phenomena such as pollution and global warming. IT accounts for a surprisingly large fraction of global energy consumption, estimated at 10%. Hence, energy efficiency in computing is a critical and necessary research area, called green computing. The laws of physics, Landauer principle in particular, fix a lower bound to the amount of energy needed to perform an irreversible computation, proportional to the number of bits of information discarded by it. Classical computing discards large amounts (e.g., x=0 on 64 bits discards 64 bits), while reversible computing (RC) discards none, avoiding Landauer’s lower bound. Although the fraction of energy lost due to Landauer principle is a currently small (around 1‰), it will become increasingly relevant as hardware technology improves. It is our conviction that in the near future RC will become a main player in the quest for energy-efficient computing. We call such transition the RC revolution.The world, EU research, and software industry in particular, are not ready for the RC revolution. RC is a young and relatively small area, albeit with breakthrough applications in robotics, debugging, and parallel simulation. Reversible programming languages exist, but they are at the stage of academic prototypes, missing key elements such as error handling and modularity, libraries of relevant algorithms, and high-level tool support. E-CoRe aims at setting the stage for the RC revolution by forming a community of experts with deep understanding of RC intricacies, who will improve and popularize RC languages, algorithms and architectures, in particular in energy-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'OntoGrid: PAVING THE WAY FOR KNOWLEDGEABLE GRID SERVICES AND SYSTEMS' (ONTOGRID) under Sixth Framework.

assistant: **Objectives**

One of the greatest challenges in Grid Computing (GC) regards the ability to explicitly share and deploy knowledge to be used for the development of innovative Grid infrastructure, and for Grid applications - the Semantic Grid (SG). ONTOGRID objective is to produce the technological infrastructure for the rapid prototyping and development of knowledge-intensive distributed open services for the SG. The results aim at developing grid systems that optimise cross-process, cross-company and cross-industry collaboration, which ONTOGRID will show by adopting a use case-guided development and evaluation strategy based on two test case applications, delivering a prototype at the project's end. The project will develop a new methodology together with a framework and reference architecture for the SG, compliant with the OGSA, driven by requirements from, and evaluated against, two use cases: Quality Analysis for Satellite Missions (involving integration of heterogeneous information sources) and Insurance settlement (involving large number of human and computational services and information transport). Within this framework we will enhance current Knowledge Technologies (ontology tool suites, software agents & negotiation techniques, metadata annotation, reasoning methods), to be Grid-aware (or Grid-enabled) in order to become scalable, secure and robust. These services and technologies will allow us to enable a selection of Grid Services (GS) to become knowledge aware/assisted and to show how GS might operate at the knowledge level. The resulting infrastructure will be subject to algorithmic analysis and performance evaluation for the SG components. ONTOGRID will cooperate with other FP6 projects. It will make its results available to them and solicit their cooperation to influen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Transfection Ability and Intracellular Pathway of LbL Nanostructured siRNA Delivery Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The scientific objective of the research carried out in this International Research Staff Exchange Scheme, is the development of a new technology to effectively deliver siRNA to cancer cells by the embedding of a polyplex into the multilayers and multifunctional nanocapsules. We propose to target pro-survival and anti-apoptotic factors in human cancer cells by using siRNA encapsulated into polyelectrolytes nanocapsules.When siRNAs are formulated into degradable polymer nanocapsules they may be protected from nuclease digestion and last longer than naked siRNAs improving their efficacy and therapeutical properties. These capsules will be prepared by the LbL deposition of interacting polymers onto a sacrificial porous colloidal template followed by core removal. Nanoengineered micro-nanocapsules composed of sequentially assembled polymer layers hold immense promise for a variety of biomedical applications. Furthermore the optimization of intracellular pathway of nanostructures may likely be a key for the development of effective nanoparticles based targeted therapeutics. As the challenge of siRNA delivery by nanocapsules is met, it will be possible to advance RNAi therapeutics rapidly into clinical studies for many diseases, including some which remain untreatable or poorly treated by conventional drugs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tidal Disruption Events: A New Black Hole Census' (TIDALWAVE).

assistant: **Concept**

Massive black holes (MBHs) are key players in high energy astrophysics, galaxy formation and evolution, and astroparticle physics. Despite their centrality to astronomy, we still cannot answer basic questions about MBHs. What are their origins? How have they grown over cosmic time? What are their current demographics? To answer these questions, the project will turn tidal disruption events (TDEs) from curiosities into reliable probes of MBH parameters. A TDE occurs when an unlucky star passes too close to a MBH and is ripped apart by tidal forces. The ensuing fallback of debris powers a highly luminous, potentially multimessenger flare. TDEs are, in principle, ideal probes of MBH properties. Unlike standard techniques for measuring MBHs, TDEs (i) happen in all galaxies, (ii) are visible to cosmological distances, and (iii) involve very few free parameters. But the theoretical picture of TDEs remains confused, as the large dynamic range of TDEs has prevented ab initio simulations to determine how tidal debris evolves and radiates. At present, there is no consensus on the geometry or even the power source of observed TDE flares, making robust parameter estimation impossible. I will solve these open theoretical questions, capitalizing on my recent pilot study that for the first time ever simulated a typical, first-principles TDE.This project will deliver (a) first-principles simulations of the evolution and emission of TDEs; (b) idealized but accurate models of TDE light curves and spectra suitable for parameter estimation; (c) a first-ever sample of MBH parameters derived from fitting ab initio models to TDE observations. I will use these results to sidestep the limitations of other MBH measurement techniques and to place unique constraints on the formation and growth his
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'NANO-scale VIsualization to understand Bacterial virulence and invasiveness - based on fluorescence NANOscopy and VIBrational microscopy'.

assistant: **Innovation**

In an interdisciplinary project, we will prototype a next-generation super-resolution microscope (SRM) and demonstrate its capability to bring about a major leap forward in our understanding of inter- and intracellular processes, and thus the cellular origin of diseases. Based on the recently invented MINFLUX concept, which pushes spatial resolution an order of magnitude beyond any other SRM technique, and by concerted development of detector technologies, lasers and image acquisition procedures, we will be able to retrieve information, not within reach by any other photonics-based technique. By extending operation to the near infrared, a hitherto un-accessible spectral range for SRM, we will strongly reduce phototoxicity and scattering, increase penetration depth and provide an additional spectral window for multiplexing. The developed prototype will allow nanometer-scale protein localization patterns to be resolved and to be placed in a cellular context by overlaid morphological, biochemical and metabolic images generated by label-free stimulated Raman scattering (SRS) and two-photon excitation (TPE).In a lead application, we will use the unique capabilities of the to-be-developed technology to study the molecular mechanisms underlying pneumococcal disease, largely attributed to localization patterns of specific bacterial surface proteins, and their intricate interactions with immune and host target cells. Pneumococci are a major contributor to morbidity and mortality worldwide and we aim to provide vital information which can lead to new treatments and vaccines. We will also offer hands-on access to the technology to researchers from both academia and industry in an open demonstration facility. Together with the lead application, this will generate demand for microsc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Short-term exchanges of early career scientists in environmental biotechnology between the european union and the united states' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The proposal seeks to foster collaboration between the European Union and the United States in environmental biotechnology through the exchange of early career scientists between recognized laboratories. Support is sought for ten short-term transatlantic exchange fellowships. A comparable application for exchange of ten US scientists is submitted to US federal agencies. The fellowships will cover travel to the host laboratory; housing and living expenses and they will permit the acquisition of new skills and expertise in environmental biotechnology during a three- to twelve-month stay in a US laboratory. The host institution will provide the EU fellow with an opportunity for new technical knowledge, a good infrastructure, basic supplies and exposure to an intellectual climate of excellence. The selection of the fellows will be based on the highest standards of scientific merit.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REsearch to improve PROduction of SEED of established and emerging bivalve species in European hatcheries' in the context of a Seventh Framework call.

assistant: **Objectives**

Secure and stabilised hatchery production of bivalve seed is the unifying objective of the REPROSEED project. Development of innovative new methods will lead to high quality seed of guaranteed physiological health, sanitary status and genetic diversity. By considering the biology of bivalve life stages and the trophic and microbial environment of rearing conditions REPROSEED researches ways of controlling key processes, like reproduction, larval rearing and metamorphosis. New technological advances, like recirculation systems and outdoor algal culture, will provide ways to reduce costs. The need for hatcheries is growing in Europe due to demands from the shellfish industry for quality juveniles and concerns about wild seed due to inconsistent spatfall or environmental harm caused by seed collection of some species. Four economically important molluscs were selected to represent these needs: two species already reared in hatcheries, Crassostrea gigas and Pecten maximus, and two emerging hatchery species, Mytilus edulis and Ruditapes decussatus. Scientific research is most advanced for C. gigas, so its further development will enable us to attain a level of excellence. Knowledge on this species and on P. maximus, an excellent model for solving particular bivalve rearing problems, can also help improve hatchery culture of the other species. Inter-specific differences enable comparative study of important traits. REPROSEED investigates the physiological basis of early sexual maturation, gamete competency, immunity and metamorphosis, at cellular and molecular levels, including genomics and proteomics. Application of these results and dedicated studies will be made on practical aspects of controlled bivalve reproduction, nutritional needs for broodstock conditioning and larva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pre-commercialization of stable and compact lasers for atom based quantum technologies' (SLAQ).

assistant: **Concept**

Optical transitions in atoms and ions are used in precise interferometry, quantum computation (QC) and accurate clock applications, and the research in these fields has led the birth of a laser spectroscopy industry. Currently, this industry is growing, and smaller lasers are already finding their way into exciting transportable applications, such as rockets. QC possesses extensive market potential, and is expected to surpass the $2 billion mark over the next five years. QC industry is a forerunner in adopting tomorrow’s technologies, and the demand they create for new high-tech will also benefit other domains. Currently, QC is facing an enormous bottleneck –  computers occupy large spaces in a way reminiscent of the 1960’s, when personal computers filled entire rooms but could carry out only the simplest operations. At the heart of miniaturization efforts for quantum computers are compact, reliable and inexpensive laser systems.In our laboratory, we faced the very same problem with our laser spectroscopy setup and were frustrated by the amount of time we had to devote to maintenance. We made an exciting innovation to overcome the current challenges. The key lies on the design of our Extended-Cavity Diode Laser (ECDL)-based setup, which combines the best features of current laser configurations (Littrow/Cateye). We use a novel design which makes the operation of the ECDL virtually free from any mechanical hysteresis-related problems. We can also fit the laser inside a miniaturized power supply, and achieve a considerably smaller volume for the unit. Therefore, we can create a compact, reliable and cost-effective laser system attractive for various applications. In the PoC, we will carry out a technology PoC and a commercialization PoC to improve the time to market of ou