RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intraprotein signalling in heme-based sensors: the oxygen sensor FixL' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

This project aims at elucidating the mechanisms of intra-protein signalling and gaseous ligand discrimination in a heme-based gas sensor. As a model system, I propose to study the bacterial oxygen sensor FixL.This protein contains a sensory PAS domain, which regulates the activity of a histidine kinase domain via the binding/release of oxygen to the heme. Structures of the O2-bound and unliganded isolated heme domain are available and provide models for the start- and endpoints of the intra-domain signalling process.However, information on the intermediate pathway is lacking. In addition, the transmission to, and the influence of, the enzymatic domain, have not been taken into account. To address these issues, this proposal describes an approach integrating molecular biology, biochemical, ultrafast spectroscopic, and computational techniques.Based on structural information and simulations, substitutions of residues potentially involved in the signalling pathway are designed. The initial set of mutations concerns residues in the heme pocket and in the 'FG loop', which is located at the presumed interface between the constituents of the functional homodimer.The corresponding proteins will be over-expressed, as isolated sensor domain, as well as full-length proteins. Strategies are devised to address the challenging task of isolating stable and sufficient full-length proteins for spectroscopic analysis.To generate intermediates in the signalling pathway, the unique possibility to photocleave the heme-ligand bond will be exploited. Using ultrafast absorption and vibrational (Raman and infrared) spectroscopy, this allows the characterization of the electronic and structural properties of transient states and their dynamics, with femtosecond time resolution.Along with molecul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Magnetic Sounding of Mars'.

assistant: **Objectives**

Magnetic sounding is a powerful tool to explore the interior structure of a planetary body because electrical conductivity carries information on mineralogy, temperature and volatile content. We propose to apply this to Mars and thus shed light on important questions such as crustal water and therefore habitability of extraterrestrial bodies.Magnetic sounding relies on the principle that external fields induce currents in the subsurface. These induced responses provide information on subsurface electrical conductivity structure and can be measured from orbit and on the ground. While a range of techniques have mainly been developed for terrestrial investigations, this field of study has mostly been unexplored for other planets. Here, the magnetic field environment dictates the nature and geometry of the inducing external fields, and often times limited data sets pose new challenges. We plan to fully exploit martian data sets from orbit and on the ground to (1) characterize the magnetic field environment of Mars and (2) explore the electrical conductivity structure within the planet. This project will also pave the way for applying magnetic sounding methodologies to other terrestrial bodies, including Merurcy or the Moon.The deep interior of a planet or moon carries information on its formation and evolution and contributes to the goals of ongoing planetary missions such as the InSight mission to Mars. InSight, the first surface mission equipped with a magnetometer landed on Mars last fall and the host professor and the candidate are involved as Co-PI on the seismometer team and as science investigator on the magnetometer team, respectively. This Fellowship will therefore contribute and further consolidate ETH involvement with InSight. Finally, Martian seismic activity th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of a design-through-analysis methodology based on a coupled isogemetrcic-maximum entropy approach'.

assistant: **Innovation**

Although from an historical point of view Computer Aided Design (CAD) and Numerical Analysis have always been two detached engineering disciplines, a lot of effort has been made over the last few years to seek a tighter integration between them. The recent development of Isogeometric Analysis (IGA) was one of the main achievement in this direction. The key idea of IGA is to use for the Analysis the same basis functions employed for the CAD representation, which in most of the cases are non-uniform rational B-splines (NURBS). However, the tensor product nature of NURBS poses some limitations in the trivariate volume parametrization of complex shapes and in local refinement, operations that are not needed for CAD purposes but are particularly important for the Analysis. This project aims at developing a coupled approach where IGA is blended with the Maximum Entropy meshless approximants, in order to overcome to such limitations, which prevents IGA to fully develop outside of the academic world into industry, and thus to create a design-through-analysis methodology with many potential industrial applications. Such methodology will be first developed for three-dimensional applications in the framework of NURBS boundary representations and then alternative frameworks, based on T-splines and subdivision surfaces, will be also explored. The application of the method to practical problems of industrial relevance will be then considered in detail. The programme will boost the career prospects, increase employability and widen the set of skills of the experienced researcher.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Making Sense of Human-Human Conversation Data' to be submitted under Seventh Framework.

assistant: **Abstract**

The overall goals of the SENSEI project are twofold. First, SENSEI will develop summarization/analytics  technology to help users make sense of human conversation streams from diverse media channels. Second, SENSEI will design and evaluate its summarization technology in ecological environments, aiming to improve task performance and productivity of end-users.Conversational interaction is the most natural and persistent paradigm for business relations with end-customers or users. In contact centres millions of customer spoken conversations are handled daily. On social media platforms hundreds of millions of blog posts are delivered through generalist or proprietary platforms. In both cases, conversations have little impact on the intended target listeners" due to the volume, velocity and diversity (media, style, social context) of the document streams (spoken conversations and blog posts).  Most language analytics technology is limited in that it performs keyword search, which does not provide automatic descriptions of what happened, who said what, which opinions are held on what subject, in a coherent, readable and executable form.  In the SENSEI project we plan to go beyond keyword search and sentence based analysis of conversations.  We will design and adapt lightweight and large coverage linguistic models of semantic and discourse resources to learn a layered model of conversations. SENSEI will address the issue of multidimensional textual, spoken and metadata descriptors in terms of semantic, para-semantic and discourse structures. The combination of supervised and unsupervised learning techniques will support the scaling and adaptation of such computational models to the diversity of the conversation data. Automated generation of readable analytics documents (summ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'CONSENSUS AND COORDINATION IN TA RESULTS EXPLOITATION PROJECT' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The CONCORD II will promote the general development of telematics applications in Europe by harmonising applications requirements and the relevant telematics infrastructure. It will put in place a mechanism to derive the common requirements gained in the telematics applications projects being implemented in the different sectors, collect the most relevant results in terms of suitable solutions and capture such information in Infrastructure Evolution Recommendations (IER). Results and solutions will then be submitted to a wider users' community for discussion, comments and finally validation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'models, EXperiments and high PERformance computing for Turbine mechanical Integrity and Structural dynamics in Europe' (EXPERTISE) targeting Horizon 2020.

assistant: **Abstract**

Energy and Mobility are two primary driving forces in the 21st century. Development of incremental and disruptive technologies will have key impacts on the world’s societies, and on safety, security and competitiveness of Europe. Amongst those technologies, gas turbines will play a major role. Recovery of shale gas depends decisively on compressors. Modern gas supplied power plants are bridging towards the age of renewable energies. Aeroengines are to undergo the most massive changes in their history with the advent of composite materials, gear boxes, and turbine-electric concepts separating generation of power and thrust. A technological commonalities of the upcoming challenges is the need for full model based development and computer system simulation.There is agreement on this in the computational fluid dynamics (CFD) community. The structural dynamics and vibration questions are at present far from being addressed adequately. While US agencies and Asian powers have already started to prepare themselves, European research organisations and companies still seem to be too fragmented to reach critical research ressources and start corresponding initiatives. There are two main reasons for this. First, the physics of mechanical joining technologies that dominate the damping behavior of the large-scale structures under debate, are still poorly understood. Second, there is a lack of high performance computing (HPC) capabilities in structural dynamics, which goes back to the lack of knowledge of effective HPC technologies for structural dynamics. Since the US, China and India have started efforts in the field, we propose a European contribution through a Marie Curie ETN to allow a first generation of early stage researchers to catch up on the topics, ideally open up new fiel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Life and death in Doñana National Park (Spain): palaeontological and ecological insights from the study of modern vertebrate death assemblages' (Spain) under Horizon 2020.

assistant: **Objectives**

Taphonomy is the interdisciplinary science, between the fields of biology and geology, that evaluates the transition of live organisms into death assemblages and, eventually, into fossil remains. Modern death assemblages provide a basis for understanding what components of living communities may be preserved in the fossil record and what biases are to be expected. Also, methods and discoveries of taphonomic research in modern ecosystems are of value to ecologists because skeletal remains hold a wealth of information about the vertebrate species inhabiting an ecosystem. Despite the interdisciplinary information that these studies contain, naturally occurring bone accumulations are largely unexplored and have not been studied neither in the European realm nor in a Mediterranean ecosystem. We propose here a training-through-research project based on the taphonomic monitoring and fidelity evaluation of the vertebrate death assemblage (mainly >5 kg terrestrial vertebrates) of a UNESCO World Heritage Site, Doñana National Park (DNP) (Spain). The candidate has experience in the taphonomic reconstruction of fossil sites but has limited exposure to taphonomic field techniques and analyses of modern death assemblages and live:dead fidelity studies. The LiveDeadFossil project will broaden her professional experience and contribute to her growth as independent researcher. The research will shed light on the ecological and post-mortem processes undergone by vertebrate remains in a Mediterranean ecosystem and will complement the study and management of the vertebrate communities of the park. The selected host organization, Doñana Biological Station-CSIC (Seville, Spain), is a world-class research center for ecology and conservation biology, manages all the activities at DNP and has a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Novel wide activity insecticide toxin for non specific biopesticide production' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The wide use of chemicals in Agriculture, especially in the field of insect pest control, has significant consequences on the environment and human health. This problem raises the emergence of new technologies and products, like Bio pesticides appear as the best way in the development of sustainable processes. Current bio pesticides are often too specific to be used against a wide range of diseases. The aim of this project is to develop a new insecticide that will promote the reduction of chemicals in Agriculture. The isolation of a new bacteria strain providing new insecticide properties will be investigated in this work. The Photorhabdus species that has been isolated from the nematode produces high molecular weight toxins. Their pathogenic potential is considered for the development of a new biological pest control agent Supported by DNA-based techniques, the objectify will be the cloning and production of the protein that have insecticide activity. The new biological products will be tested in the Agriculture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European Genetic Disease Diagnostics' (EURO-GENE-SCAN), addressing dissemination and exploitation.

assistant: **Impact**

Molecular techniques have become more efficient, increasingly precise and much cheaper, resulting in an unprecedented discovery rate of inherited disease genes. In areas such as primary immunodeficiencies (PID), muscle disorders, growth deficiencies, hearing/vision impairments and metabolic diseases, very large numbers of different genes have been found to carry mutations in diseases with heterogeneous clinical presentation. For example, mutations in almost 150 genes have been found to cause PID. This means that even for well-defined subgroups of PID, mutations in different genes result in identical, or overlapping, phenotypes.  Current mutation analysis is very complex, often with many different European laboratories being involved. Thus, individual laboratories carrying out mutation detection normally only cover a few per cent of all disease genes. Obtaining a correct diagnosis is both difficult and time-consuming. If multiple genes need to be analyzed, the cost rises proportionately.  New sequencing approaches have been used for the analysis of whole genomes. We will adapt these technologies, based on massive, parallel sequencing, to specific disease fields. This will involve the development of an innovative multiplexing technology. The proposed prototype area is PID, where significant collaboration has already been underway in Europe over the last two decades. We estimate that, using high-throughput sequencing, the cost for analyzing all known 150 PID genes in a single run will be in the same range as the current cost for mutation detection in single disease genes.   We will also develop chips to identify single nucleotide polymorphisms (SNPs) for the study of modifier genes. In addition, we will develop reverse-phase protein arrays for proteomics approaches in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Hunting for Sustainability'.

assistant: **Concept**

Biodiversity conservation increasingly takes place outside protected areas in multiple-use landscapes. Success in achieving biodiversity objectives is closely linked to the extent to which conservation can be integrated with the cultural, social and economic objectives and aspirations of people. Beliefs, perceptions, attitudes and preferences about biodiversity are central to the decisions made by individuals and groups about natural resource management. In this project we will use hunting as a “lens” through which to examine the wider issue of how people interact with biodiversity. Hunting provides a valuable case study in the use of biodiversity because it involves tens of millions of people globally, it is conducted across a wide range of land tenure and use systems, and it is an important source of revenue and protein, particularly in developing countries. Hunting is embedded in social structures and cultural patterns and has a key role in conflicts over natural resource management around the world. Our multidisciplinary team will assess the social, cultural, economic and ecological functions and impacts of hunting across a range of contexts in Europe and Africa. Our study systems fall across economic gradients from the richest to the poorest countries and encompass environments from the Arctic to the Equator. We seek to understand what influences attitudes to hunting, how these attitudes influence and determine individual and societal behaviour in relation to hunting, and finally, how hunting behaviour influences biodiversity. Consequently, we will integrate social, economic and ecological scientific disciplines and engage with a diverse selection of stakeholders to develop novel approaches to the mitigation of natural resource conflicts involving hunting. Finally,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Novel Cyclocarbon-Porphyrin Systems: Synthesis and Properties' under Horizon 2020.

assistant: **Concept**

The proposed project combines recent advancements in supramolecular porphyrin systems and polyyne chemistry to create and study novel hybrid compounds: carbo-porphyrin nanorings. This will include extensive synthetic work to find the most efficient working schemes for macrocyclic compounds with varying sizes and different peripheral substituents, while minimizing linear polymerization. Specific choice of the building blocks will be guided by computer-aided design to ensure appropriate connectivity and steric demands for subsequent cyclooligomerizations. The size selectivity will be further refined by using template-assisted covalent self-assembly utilizing differently coordinating templates. The electronic and magnetic nature of the target compounds will be studied in solution using a range of techniques, including Nuclear Magnetic Resonance spectroscopy, UV-vis-NIR absorption and fluorescence spectroscopy and electrochemical methods, additionally characterized with X-ray crystallography in the solid state. These efforts will be focused on exploring global aromatic and antiaromatic currents in the neutral and oxidized forms of the macrocycles, gaining insight into the nature of aromaticity in nanometer-size pi-conjugated systems and contributing to the design of future functional materials.