RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'REGULATION OF APOPTOSIS in TISSUE HOMEOSTASIS AND CANCER : ROLE OF TNF-R1 AND Fas/APO-1' in the context of a Fourth Framework call.

assistant: **Objectives**

Recent evidence suggests that not only unrestricted cell proliferation but 1. Each of the young postdocs is supposed to be educated for at least 3 also the inability to undergo apoptosis in response to physiological months in at least one of the other collaborating groups. signals contributes to diseases such as autoimmunity or cancer. Aim of the It is also planned to exchange personnel in such a way that experiments are performed in the most adequate laboratory where project is the definition of the molecular requirements for the generation a certain technique is routinely performed, e.g. a biochemical and intracellular transmission of the apoptotic signal from surface assay or construction and production of retroviral gene transfer vectors. receptors. The model we are using is represented by two highly related receptors, the tumor necrosis factor type 1 (TNF-R1) and the Fas/APO-l 3. Each spring a course is to be held to help distributing important receptor. Cross-linking of TNF-R1 and Fas/APO-l by their specific ligands technologies and knowledge from within the network. This course is also supposed to be open to other members of the network laboratories triggers a cascade of still largely undefined events leading to apoptosis. such as graduate and undergraduate students. In detail, we will address the following: 1. the function of death-domain containing proteins in signaling. 4. Each autumn a meeting is to be held in one of the participating autumn a meeting is to be held in one of the participating countries. The 2. signal transduction (phospholipid messengers, MAP kinase cascade. young postdocs and the graduate students are expected to join these 3. role of gatekeeping molecules (p53 and the bcl-2 family) meetings. 4. role of downstream effectors (ICE/CASP-Proteas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Conflict prevention through integration: The participation of ethnic minorities in political decision-making processes - The case of Roma in South Eastern Europe' under Sixth Framework.

assistant: **Concept**

The Project Conflict prevention through integration: The participation of ethnic minorities in political decision-making processes - The case of Roma in South Eastern Europe" (Acronym: ROMA PARTICIPATION) is an ambitious multidisciplinary research and training project aiming at contributing to a better understanding of current problems of social and political exclusion of Roma and the development of democratic infrastructure which could provide relief. The emphasis of the analysis lies in the field of comparative law. Within the project the actual functioning of legal instruments in several countries of South Eastern Europe will be investigated based on the method of functional analysis of norms. Field studies and on site observations (Roma settlements and communities), study of available statistical data, interviews with relevant individuals and institutions ("key-players"), etc. - using sociological, anthropological and political science methodology - are also part of the project. Emphasis will be laid on communication with Roma and participative integration of them in the project performance.An innovative aspect of the project will be the integration of aspects of e-democracy. In the project the effects of those representation and participation-models will be examined, which are contributing to an integration of Roma and therefore to lasting peace and stability and the avoidance of exclusion and violence. By means of selected regulations in several countries of South Eastern Europe it shall be proved, that a legal guaranteed representation and participation of Roma can contribute to peace between different ethnic communities. The applicant will develop her scientific excellence on these issues and build its respective knowledge base with a concrete view on potentials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'WIDE MARITIME AREA AIRBORNE SURVEILLANCE' (WIMAAS).

assistant: **Concept**

WIMA²S addresses the Airborne building block of maritime surveillance with the potential for reduced cost of operation, more autonomous and improved efficiency through the introduction of air vehicles with reduced or zero onboard crew. Innovative concepts are required to support the integration of these new vehicles in a future European maritime surveillance system of systems. With 20 million km2, the surveillance of the European maritime domain has to be improved, according to the European Council, EC and Agencies such as FRONTEX. The urgent need is to control illegal immigration, but WIMA²S will also contribute to other missions. “You cannot control what you do not patrol”. Even if cooperation is crucial, Air assets are a unique capability for wide area maritime surveillance because they provide situation awareness over extended areas (endurance, speed and long distance detection), re-direction to areas of interest (threat) and flexible reaction (inspection when needed). WiMA²S will develop concepts and technologies for better operational use at lower costs of: - Maritime Surveillance Manned Airborne Vehicle (MS MAV) including existing Mission Aircraft with zero or reduced onboard tactical crew - Maritime Surveillance Optionally Piloted Vehicles (MS OPV) because regulations will not allow UAVs to fly across European Airspace for years to come. Intermediate solutions are required - Maritime Surveillance Unmanned Airborne Vehicle (MS UAV) because they will become a future key solution Supported by a User Group, WIMA²S consortium will provide tangible results: - Simulation based on operational scenarios - Innovative concepts and technologies held by simulation (algorithmic modelling, remote control, sensor data fusion) - In flight experiment (remote control, crew concept
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Intimate Dispossession: The Afterlives of Plundered Jewish Personal Possessions in the Aftermath of the Holocaust' (2021-2027).

assistant: **Innovation**

This project aims to write the history of the great plunder of small thingseveryday household objects, and personal items, including clothing, looted on a mass-scale by local non-Jews during, and in the aftermath of, the Holocaust. While historical research has focused on the top-down and centralized Nazi states takeover of Jewish financial assets, real estate, businesses, or art objects, we know nothing about the afterlives of unmarked objects of daily use that changed hands in the course of the Holocaust and continued being used for decades in the small local communities of East-Central Europe. The main objectives of the project are to document different modes of how Jewish personal possessions were appropriated by non-Jewish local populations of East-Central European shtetls; examine how they have been redeployed, adapted, and misused by their new owners; and assess the social and psychological trans-generational impact of this kind of plunder on the communities of both the beneficiaries and the victims. Breaking with the top-down view on Holocaust dispossession, this project focuses on eight microstudies of communities located in three different administrative units of German-occupied East-Central Europe. PLUNDERED LIVES novelty is in a combination of a microhistorical analysis with qualitative approaches of social studies and social psychology; extending the typical time frame (1939-1945) to include dispossession practices that continued after WWII; and experimental outreach strategies of digital crowdsourcing, curatorial interventions in public spaces, and cross-generational interviewing to elicit responses from the implicated communities and document hitherto inaccessible material in private possession. Highly interdisciplinary, PLUNDERED LIVES will open avenues
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Deciphering the role of protein S-palmitoylation in skeletal muscle physiopathology' (MyoPALM) targeting Horizon Europe.

assistant: **Abstract**

Duchenne muscular dystrophy (DMD) is the most prevalent form of childhood muscular dystrophy, affecting approximately 1 in 3500 newborn boys. DMD patients experience early-onset and rapidly progressive muscle weakness, leading to the loss of mobility and premature death. The burden of muscular dystrophies extends beyond the physical challenges faced by patients, indeed it poses significant social and economic implications, impacting patients’ quality of life, necessitating social welfare support and incurring substantial healthcare costs. So far there is no cure for DMD, emphasizing the urgent need to intensify research efforts aimed at uncovering new pathomolecular mechanisms and developing treatment strategies. Protein lipidation, especially protein S-palmitoylation, has gained attention in several diseases, but its role in skeletal muscle function and dystrophic conditions remains completely unexplored. MyoPALM is an innovative project that aims to bridge this knowledge gap by investigating the contribution of protein S-palmitoylation in adult skeletal muscle function. This will be accomplished through in vivo manipulation of the enzymes involved with this pathway and using cutting-edge palmitoyl-proteomic approaches. Furthermore, by exploiting the mdx mouse model, we aim to explore the potential role of protein S-palmitoylation in the pathogenesis of DMD. By unravelling this unexplored perspective, MyoPALM aims to lay the foundation for identifying new druggable targets, paving the way for future therapeutic strategies to benefit DMD patients. Through collaboration between the École Polytechnique Fédérale de Lausanne (CH) and the University of Padova (IT), the applicant seeks to reinforce his technical skills and scientific knowledge, aspiring to become an independe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Arthritis Differential DIagnostic validaTION' (ADDITION), addressing dissemination and exploitation.

assistant: **Impact**

Arthritis, a group of diseases involving inflammation of joints with huge health and socio-economic impacts. Early Arthritis(EA) describes newly diagnosed arthritis (incidence 2/1000). An improved arthritis management requires to enhance the EAdifferential diagnostic efficacy and the adequacy of the therapeutic strategies. The earlier arthritis is addressed, the morelikely its progression will be limited. A mistake in differential diagnostic leads to inappropriate treatments, resulting in uselessexpenses and serious side effects, unjustified. Current diagnostic techniques are unsatisfactory and the most used first linetreatment, Methotrexate (MTX), is ineffective in about 40% of the patients. RheumaKit is a solution for clinicians for the earlydifferential diagnostic of patients suffering from undifferentiated arthritis (UA, a subclass of EA). RheumaKit is based on atrancriptomic signature of about 100 genes complemented by 3 clinical factors. It provides a 90% accuracy for theRheumatoid Arthritis (RA) vs non-RA distinction, far above the ACR/EULAR2010 criterion on the same patients. It alsoprovides probabilities for Osteoarthritis and Seronegative Spondylarthropaties. The solution consists of a synovial biopsycollection and transportation kit (CE-marked May 2014), a central lab PCR procedure, and a web application computing theeffective diagnostic on a cloud-computing infrastructure. Functional, technical, logistics aspects of RheumaKit have beenvalidated. ADDITION aims at clinically validate on a larger patient cohort the existing RheumaKit signature for the differentialdiagnostic of most EA patients and validate the use of the existing RheumaKit signature as a tool to predict MTX response.ADDITION phase 2 will involve a prospective study on 500 to 1000 EA patients. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Homogeneous Flows and their Application in Kinetic Theory'.

assistant: **Objectives**

Since the pioneering work of Maxwell and Boltzmann in the 1860s and 1870s, a major challenge in mathematical physics has been the derivation of macroscopic evolution equations from the fundamental microscopic laws of classical or quantum mechanics. The key idea of the present proposal is to introduce a renormalization technique that will provide a new route to attack some of the most important questions in the kinetic theory of gases. This technique uses the ergodic theory of flows on homogeneous spaces (homogeneous flows for short), and builds on my recent breakthrough in the case of the Lorentz gas (in joint with Andreas Strömbergsson, Uppsala). The key feature of the proposed approach is measure rigidity, a deep and powerful technical tool that has so far mainly seen success in solving long-standing problems in number theory and quantum chaos. The arguments developed in this proposal are not only interesting from a rigorous mathematical viewpoint, but also yield a heuristic mechanism for finding previously unknown kinetic transport equations that incorporate the effects of long-range order in microscopic particle distributions. This project joins together two distinct research fields, kinetic theory and the ergodic theory of flows on homogeneous spaces. If successful, the proposed research will constitute a significant breakthrough in the subject.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Imaging the Dynamics of Electrons with Attosecond and Angstrom resolution' (IDEAA).

assistant: **Innovation**

IDEAA targets the synergistic creation of experimental and theoretical toolboxes, leveraging innovative attosecond time-resolved X-ray techniques, to capture electron dynamics within molecules with unprecedented ångström and attosecond resolution in space and time. Access to the electron time scale in molecules has opened tremendous new perspectives to direct chemistry through pathways otherwise not accessible by conventional chemistry, ultimately creating novel light harnessing approaches that enhance the efficiency of photochemical protocols. Despite strides in the understanding of how numerous electronic and vibronic interactions drive the responses of molecules, the precise control of reaction pathways remains elusive. In our ambitious project, we will use attosecond X-ray crystallography and soft-X-ray attosecond interferometry to create ""molecular movies"" with electrons as the central actors. We pioneered the experimental investigation of charge migration—rapid electron density variations within molecules—that defy traditional chemical expectations by altering bonding patterns. Yet, challenges remain in spatially resolving the dynamics of valence electrons at an atomic scale. Tremendous progress at X-ray free-electron laser facilities have made attosecond X-ray pulse generation a reality. Our team leads in this arena, largely contributing to advancements in X-ray time-resolved techniques at the European XFEL and with table-top sources. The pivotal developments of the IDEAA project combine attosecond science with atomic imaging, allowing unprecedented observation and control of chemical transformations. By combining three ground-breaking innovations in methodology and analysis, this project aspires to redefine photochemical reaction engineering, pushing the bound
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Master Framework and Pragmatic Clinical Trial for Relapse or Refractory Acute Myeloid Leukemia' (2021-2027).

assistant: **Innovation**

In IMPACT-AML, a multidisciplinar R/R AML represents a model of high-impact disease, in which no standard of care exists, and where we have an urgent need for new evidence on possible therapies; AML offers the setting in which methodological innovation will combine powerful instruments of clinical trials with personalized medicine through academic efforts. Hereby, we propose to create an inclusive master framework for relapsed or refractory acute myeloid leukemia (STREAM) to include patients with R/R AML across Europe proficiently acquire an unselected population for clinical trials and monitor outcomes including neglected cohorts. Thereafter we will conduct a prospective randomized pragmatic clinical trial (RPCT) that will compare the classical “high intensity” rescue chemotherapy with biology-driven, “low intensity” rescue to obtain “real world” data on the benefit of one of the two different strategies in term of survival also considering patients and caregivers preferences, patient-reported outcomes (PRO), accessibility, affordability, and social cost. RPCT will aim to evaluate the effectiveness of real-world clinical alternatives in routine care. In addition to retaining the high internal validity of traditional randomized trials, it will maximize external validity, i. e. generalizability of results to many settings. In this context, the inclusion of an RPCT in the master framework will allow a dynamic inclusion and the collection of the excluded population as an instrument to predict the real-life applicability of clinical trial results. We will offer Europe results from an ambitious project, that will go beyond the state of the art in R/R AML demonstrating the superiority of a strategy in a first-of-his-kind clinical trial, providing strong data that will be deli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Promoting Fairness of the Music Ecosystem in a Platform-Dominated and Post-Pandemic Europe'.

assistant: **Innovation**

The overarching goal of Fair MusE is to promote fairness for music creators and stakeholders from an interdisciplinary perspective, thus leading to a more transparent, competitive and sustainable music ecosystem in Europe. Fair MusE focuses specifically on the domination of online platforms and their algorithms and will investigate: (i) the legal responses that have been proposed in the EU; (ii) the changes these platforms have brought to the music industry and music professionals; and (iii) the impact of such algorithms on music consumption. Fair MusE will provide an interdisciplinary analysis of fairness in the music industry involving music creators and stakeholders in the research; promote and enhance transparency concerning music industry practices and standardisation in data collection in the European music ecosystem; and assess the risks created by the reinforced dominance of the largest online platforms prompted by COVID 19 as well as making policymakers, stakeholders and the general public aware of such risks. To do so, Fair MusE will provide an innovative, strong and future-proof set of co-created responses and solutions: the 'Music Copyright Infrastructure', a data-sharing model agreement enhancing transparency; a 'Music Data Dashboard' of statistical indicators on the economic and societal value of the European music sector; the 'Fairness Score', a tool to assess music services and social media in terms of fairness’ multiple facets; and a ‘White Paper’ embodying policy recommendations to enhance competitiveness, sustainability, transparency and fairness of the EU music ecosystem. Our consortium is a carefully designed interdisciplinary group of academic and industry partners with strong expertise in the fields of law, economics, political science and compute