RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polarization tracking in situ' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The technology for the growth of thin oxide films has reached the same level of atomic control as in the case ofsemiconductors. Yet, in contrast to semiconductors, oxides exhibit novel phases and functionalities like magnetic or electricorder or dramatic changes of electrical resistance. One such functionality is the spontaneous formation of an electricpolarization, called ferroelectricity, that is considered as basis for novel types of smart devices or energy-efficient functionalcomponents in CMOS devices. The infatuating technological potential of ferroelectric oxide heterostructures drives materialsscientists to master their synthesis, understanding and control. Optimizing the ferroelectric performance is tedious, however.From the post-growth invasive and destructive analysis of prototypes, conclusions are drawn on the optimum heterostructuredesign and growth parameters. Monitoring the heterostructures while they are assembled in the growth chamber wouldprovide immediate and direct feedback on the relation between growth and function and could thus immensely speed up theiterative process. The present lack of the according technique poses a restricting market factor. Here we will use a laseropticalprocess called second harmonic generation (SHG – doubling of the laser frequency) to track the emergence of theferroelectric state directly, during the assembly of the oxide heterostructure in the growth chamber. Probing occurs in situ,non-invasively and non-destructively throughout the deposition process. With our Proof of Concept proposal POLARIS, wewill cast such ""in-situ SHG"" into the prototype for a marketable system that is simply flanged onto the growth chamber. It is atechnique with a high robustness against the sometimes harsh environmental conditions of a lab or,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'How Membrane Physical Properties and Cortical Actin Regulate Protein Interactions During T Cell Signalling' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The overall aim of this project is to identify key biophysical mechanisms that control the spatial arrangement of signalling proteins and membrane lipids in the regulation of T cell activation. During an immune response, T cells are activated in response to antigenic peptides in a process that requires the formation of multi-molecular signalling complexes. It is known that many T cell signalling proteins (such as the kinase Lck and the scaffold protein LAT) are not randomly distributed within the plasma membrane thus giving rise to lateral organization which affects signalling efficiency. However, the biophysical mechanism(s) that control protein distributions and hence the rate of molecular interactions remains poorly understood. Two of the principal mechanisms are compartmentalisation of the membrane by lipid microdomains (the ‘lipid raft’ hypothesis) and by the cortical actin meshwork (the ‘picket-fence’ model). The two key technologies needed to unravel how protein clustering and the biophysical properties of the lipid bilayer regulate specific interactions at the molecular level have now been developed. These are single-molecule, super-resolution localisation microscopy and quantification of membrane biophysical properties using new-generation environmentally sensitive fluorescent probes. Using these methods, the proposed project will generate unique insights into the biophysical mechanisms that govern the formation of the protein clusters and complexes during early T cell signalling events. This knowledge is critical to our understanding of the molecular basis of T cell activation during the immune response and has potential applications in the development of therapeutic treatments for a range of conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Bioinformatics and Comparative Functional Genomics', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

To combine a meeting in Bioinformatics and a short Symposium about Post-Genome research in a EuroConference entitled  Bioinformatics and Comparative Functional Genomics " is quite interesting from a scientific point of view and quite timely for European research in genetics and for European biotechnology industry. Bioinformatics provides the key to the interpretation and exploration of massive amounts of data stemming from the Human Genome project. It requires an interdisciplinary and collaborative effort to cope with the needs of the present and future genome based research. While at present bioinformaticians represent an indispensable human resource for biomedical research, whose training has to be strongly promoted in Europe, at the same time biologists, biochemists and physicians must learn to apply bioinformatics as a problem solving tool. The data generated by high-throughput experiments will constitute a special challenge in this respect. Methods in bioinformatics must be adapted in order to interpret data in the context of the available knowledge. On the other side research activities on model organisms (or comparative genomics) will have to be combined with the methodology available to applied and theoretical bioinformatics.New forms of training have therefore to be established in order to raise the next generation of researchers in bioinformatics on one side and promote the diffusion of bioinformatic expertise among young researchers in biology and medicine on the other. Starting this year the new venue of the European School of Genetic Medicine, La Nunziata Centre, in Sestri Levante will be characterized by the availability of a well equipped multimedia laboratory. During the proposed EuroConference this laboratory will therefore be used extensively for works
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Synthesis of the c1-c28 fragment of spongistatin 1, a very potent antimitotic cancer cell growth inhibitor' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content The Spongistatins are a new class of naturally occurring marine metabolites (isolated from the marine sponges Spongia sp. and Spirastella sp. in the early 1970s), the structures of which have been recently disclosed. This new family of macrocyclic lactone polyethers has attracted immediate considerable attention, due to their potent antitumor activity against highly chemoresistant tumor types, such as human melanoma, lung, colon and brain cancers. The low availability of the molecules from the natural sponges is a serious obstacle for biological screening. Therefore, a total synthesis of Spongistatin 1, the most potent molecule of the family has been planned with efforts from two chemical laboratories. The spiroketals, caractheristic units present in Spongistatin 1, will be sinthesized by the methodology develop by the group of Prof. Steven V. Ley, already successfully applied to the construction of several other natural products. The incorporation of a degree of flexibility into the synthesis will permit the preparation of structurally related analogues, which will help in the understanding of the structure/ activity relationship of Spongistatins and their antimitotic properties. Training content (objective, benefit and expected impact) I consider that the University of Cambridge it is now one of the most important European research centers in Organic Chemistry. During my training stay there, under the supervision of Prof. Steven V. Ley, I expect to improve my knowledge and experience in Synthetic Organic Chemistry. At the moment I have carried out research directed to methodologic aspects and would gain very much by working on a total synthesis project. Links with industry / industrial relevance (22) The understanding of the structure/
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'EU evaluation policy discussing the evaluation of EU programs and defining prospects for the future', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The key objective of the workshop is to review the EU evaluation policy and to analyse the application of program evaluation in various domains (education and culture, regional policy, employment and economic development), with particular attention to the methods used and their utility for improving EU policies.The workshop is organised to promote an interdisciplinary discussion on the quality of the research that is produced in response to EU demands and on the methodological approaches that can be of use for a further development of quality program evaluation in Europe. Of particular interest is the research being undertaken by young researchers in Europe and the US and the potential utility of new approaches for the evaluation of EU programs.Another objective of the workshop is to foster the development of networks for joint research and to explore the opportunities that exist for social scientists with regard to the evaluation of EU programs.The themes of the workshop are: Policy evaluation in Europe, Professional responses to the demand of program evaluation and Policy contexts. The activities of the workshop are: Panel discussions and Symposia (to discuss major evaluations of EU programs) and paper sessions to present preliminary research results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Plug and Produce Components for Optimum Dynamic Performance Manufacturing Systems' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Self-sufficient intelligent plug-and-produce components with advanced sensing and actuating functionalities, e.g. based on smart materials. Able to adapt their range of properties, depending on the changing process conditions. Use vibration for energy harvesting to drive the intelligent system. Smart materials: compensation of static and / or thermally induced dislocations, vibration damping and decoupling of oscillations. High accuracy in production systems under different conditions and to overcome the traditional limitation of dynamics versus precision. Active participation of industrial partners, including SMEs, covering demonstration activities including pilot implementations in industrial settings.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Broadband Room-temperature Inexpensive & IndistinGuishable pHoTons' (BRiiGHT) targeting Horizon 2020.

assistant: **Abstract**

The primary objective of this proposal is to build the first cheap and technically simple source of bright single photon states that have the characteristics (including state purity, repetition rate) to power photonic quantum technologies. Photonic quantum simulators have not been able to break into the regime where they outperform classical simulators because of the intrinsically probabilistic character of the photon sources, which means that in most runs of the simulator, there is no output. By means of a new type of room-temperature quantum memory and state-of-the-art heralded parametric down-conversion photon sources, we will change this: we shall make near-deterministic single photon sources.  Briefly, a quantum memory is a device that is capable of capturing and then releasing quantum states, and are a key technology for photonic quantum technologies as they enable scalability. However, quantum memories had proved difficult to build with sufficiently low added noise, which prohibited them from operating at the quantum level. Very recently we invented and demonstrated the world’s first fast, noise-free and room-temperature quantum memory, Off-Resonant-Cascaded Absorption (ORCA). ORCA is the first full quantum memory that has the bandwidth to operate with nonlinear optical quantum light sources. Armed with our new quantum memory technology we will interface it with pure and identical photons produced via parametric down-conversion to produce BRiiGHT: Broadband Room-temperature Inexpensive & IndistinGuishable pHoTons. Our BRiiGHT module will be a rack-mounted, room-temperature, robust and inexpensive source of pure and indistinguishable photons. The outcome of the program will be the development of a technological platform that can be easily scaled up to provide the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Being There - Without Going' (BENOGO), addressing dissemination and exploitation.

assistant: **Impact**

The project will investigate and further develop novel camera technologies into an innovative mediation system that allows close to photo realistic 3D real-time visualisation of REAL (and possibly known) places for a moving observer. The visualisation will provide a high degree of impressiveness and support new types of empirical studies of the feeling of presence in a REAL scenario that is made artificially available for perceptual inspection. This is hard or impossible with conventional VR. Using this new technique in varying combinations with advanced versions of augmented reality, the project will contribute with empirical evidence to the development of a general multilevel interpretation of presence, on the basis of a context otherwise not available. The interpretation will provide a reference for empirical studies to optimise the technology in respect of aspects of presence found important for observation.OBJECTIVESThe project shall act as a melting pot for mixing novel technology, that allows real-time visualisation for a moving observer of recorded REAL PLACES, with ideas of researchers from diverse fields to develop new tools for empirical and theoretical studies of presence based on the concept of the observer's embodiment in the computationally created virtual environment. As real places (possibly known to the observer) with man-made and/or organic objects (like trees, foliage etc.) are otherwise hard to represent in a virtual environment, the aim is to bring about new insight into presence, when also comparison to real presence is possible.DESCRIPTION OF WORKTools for Presence: The project will develop and explore new recording and visualisation technologies enabling people to experience presence at REAL and possibly known places - without actually having to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Regulation of pol-eta by phosphorylation, ubiquitination and SUMOylation' (TLSCHECK).

assistant: **Concept**

Xeroderma pigmentosum variant (XPV) is an autosomal recessive genetic disorder that results in enhancced predisposition to skin cancers. XPV results from a defect in the translesion synthesis (TLS) polymerase poleta. TLS allows bypass of unrepaired damage permitting completion of replication. Poleta is phosphorylated and ubiquitinated and can interact with ubiquitin and SUMO, two post-translational modifications that are important in a number of DNA repair pathways, via multiple domains. Mutants in those domains show a defect in DNA damage checkpoint activation, pointing out an unexpected connection between TLS and one of the DNA damage surveillance mechanisms. TLS is regulated by ubiquitination of the proliferating cell nuclear antigen (PCNA). While PCNA ubiquitination is essential for TLS, new evidence suggests that is not needed for the initial recruitment of the polymerases to chromatin. The objective of this proposal is to identify how poleta’s function is modulated by interaction of a number of unknown factors with its different domains, ensuring both its recruitment when needed and its inhibition when its action would be deleterious for normal replication. I propose to dissect the checkpoint activation cascade to unveil the role of poleta in this pathway, analyze known factors involved in both the ubiquitination and SUMOylation pathways and to conduct a proteomic study of poleta to identify novel interactors which will be assayed for TLS functionality in vivo. Insight into the function of a core cancer protection pathway, plus the potential identification of new and important partners controlling poleta will lead to finding new diagnostically relevant biomarkers for XPV patients in whom mutations in poleta have not been found. In the long-term, Y-family polymeras
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'LINE-1 retrotransposition in human somatic cells' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The human genome is largely composed of non-coding DNA, only 3-5% codes for exons. The majority of the non-coding DNA is however fundamental for the correct functioning and regulation of the genome. Transposable elements (TEs) like LINEs generated up to 50% of the human genome during evolution. They can mobilize, causing mutations but also conferring genomic plasticity. The generation of new insertions in the germ line led to the concept of TEs as ‘selfish’ DNA. However, inconsistent with their hereditary transmission, it was recently shown by the host lab and others that most of the action of TEs occurs in somatic cells during early embryogenesis.Thus, to deeply understand the impact of the somatic activity of LINE elements, we propose to develop and use an in vivo mouse model for LINE transposition. We will use human embryonic stem cells (hESCs) and tissue-specific iPSCs, containing an eGFP-marked LINE reporter cassette. Once injected into immuno-suppressed mice these cells will develop teratomas containing tissues of the 3 germ layers (endo, meso, ectoderm). For the proof of principle, the host lab has injected human embryonic carcinoma cells (hECs). With this model, we aim to answer the following: 1) Are LINEs active in all three germ layers?; 2) Are LINEs differentially regulated, depending on the germ layer?; 3) What’s the impact of LINE activity in the somatic tissues?To answer these questions, we will FACS-sort parts of the teratoma into ecto-, meso-, and endoderm-like cells and map the site of new LINE insertions during development, using deep sequencing. We aim to detect hot spots of LINE integration, allowing the analysis of possible genetic and phenotypic consequences. Imaging of the rest of the teratoma will further show us cell types where transposition oc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Fatigue modelling and fast testing methodologies to optimize part design and to boost lightweight materials deployment in chassis parts' (Fatigue4Light).

assistant: **Innovation**

Fatigue4Light project aims to investigate lightweight solutions adapted to the chassis part of EV to reach a 24-30% weight reduction. This will give a 12-15% weight saving from structural vehicle weight, and also increase EV safety due to reduced sprung mass. Solutions will be based on the introduction of especially developed material solutions with high fatigue performance (AHSS, stainless steel, Al alloys and hybrid metal-FRP materials), the development of new computer modelling with high fatigue prediction accuracy and new experimental methodologies that reduce the testing time. Sustainability of the proposed solutions will be continuously considered along project through an eco-design general approach. Environmental assessments through LCA, affordability based in LCC as well as social inclusion thanks to the recovery of CRMs from alternative waste streams will allow endowing Fatigue4Light into a novelty circular dimension. Attention will be given to manufacturing processes (cutting and welding) to improve the knowledge on their effect to the overall fatigue performance of chassis components. Six lab scale and industrial demonstrators will be defined to validate the proposed solutions. The fatigue model will be verified on demonstrators and then used in a virtual testing process to assess the weight reduction potential of the proposed materials, together with a redesign process oriented to lightweight the components while ensuring structural integrity. The project will reduce lead times to market due to the developed model and advanced fatigue testing methodologies and standardization will be followed. The final outcome is to give modelling and experimental tools for the lightweighting process on chassis parts subjected to fatigue. Clear and practical guidelines will