RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The Evolutionary Genetics of Daphnia-Pasteuria Interactions', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The study of ecological immunology, which examines variations in parasite infectivity and host immunity as a result of ecological and evolutionary processes, is one of the fastest growing fields of organismic biology. Parasitism may explain various biologi cal phenomena, such as the widespread occurrence of sexual versus asexual reproduction, sexual selection, the evolution of virulence, and the maintenance of genetic diversity. Pathogens and infectious diseases have also become a major threat to wildlife co nservation and endangered species, by influencing host genetic diversity and altering species composition. Yet this very same coevolution-driven genetic diversity may buffer natural populations against widespread epidemics. Understanding the genetic and mo lecular basis of rapid, antagonistic host-parasite coevolution is of great importance, given that the vast majority of invertebrate species rely exclusively on innate immunity and do not possess an acquired immune system. The genetic approach is based on t wo conflicting models: the gene-for-gene (GFG) model of plant pathologists and the matching-alleles (MA) model of invertebrate zoologists. Using genetically-identifiable clones of Daphnia magna and its microparasite Pasteuria ramosa, we will perform a seri es of cross-infection experiments to estimate whether infection success is inherited by few genes with strong effects, or as a quantitative trait with many genes being involved. We will also look for host-mediated selection on parasites, to assess whether infection patterns correspond to the traits under selection during natural selection. These experiments will allow us to distinguish between the GFG and the MA models. The molecular approach relies on the interactions between host receptors and parasite el ic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A tool for paleoenvironment and palaeoclimate recocnstructions at a continental scale.' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

To standardise and archive palynological data, including detailed information on the specific sites, for exploitation with modern computing techniques, and to promote the use of pollen data for climate research. For several decennia palynologists have established numerous pollen sequences, which have enabled  reconstructions throughout Europe of the Younger Pleistocene and Holocene vegetation and climate history. The  European Pollen Database is standardising, archiving, and distributing these data in a form suitable for modern  computer based analysis.  The three contractors constitute the Executive Committee for the management of the database. In addition the  management structure includes an Advisory Board of 10 members representing the major European regions. The  palynological network at the base of the EPD consists of researchers from 25 countries.  The EPD was established in previous EU research programmes, but the present project is different in that the  EPD has been given an independence from specific application projects. This independence has appeared  desirable in order to help increase the number of contributions and contributors and the free access of users.  More than 500 sites have been compiled so far, and it is intended to double this number within the next two  years. The EPD organizes meetings and training courses in order to promote contributions. The management  and utilisation rules have been defined by a protocol. A newsletter is published every year. Within EPD  specialised software is being developed to facilitate the use of the data and the access of users.  EPD represents a tool for EU climate research through the establishment of palaeobiome reconstructions for the  validation of climate models.  The EPD is the natural depository for all ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Infusion of CRHR1 agonists in the lateral septum to rescue social preference in a mouse model of schizophrenia', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Patients affected with schizophrenia or social anxiety disorders such as separation anxiety or avoidant personality disorders often exhibit difficulties to socially interact, particularly with novel individuals. Altered social interactions impair their day-to-day life and often prevent them from having families or holding on to their jobs. In addition, the number of individuals living as recluses and suffering from the Hikkimori syndrome has sharply increased since the COVID pandemic. Currently, there is no dedicated medication to treat the crippling introversion associated with these disorders.We discovered a neuronal circuit regulating social preferences through the activation of the corticotropin-related hormone receptor 1 in the lateral septum (LS). Specifically, we demonstrated through a combination of electrophysiological, chemogenetic, optogenetic, calcium recording and gene silencing techniques that the release of CRH from prefrontal cortex (PFC) neurons into LS suppresses social interaction with familiar mice. This circuit therefore contributes to the social novelty preference exhibited by adult mice. based on these results, we presented a patent titled ""CRHR1 agonists for use in the treatment of social anxiety disorders"". In addition, preliminary data shows that social novelty preference as well as CRH signaling from the PFC to LS is dysregulated in the Df16(A)+/- mouse model of schizophrenia.In order to further interest for our patent from pharmaceutical companies, we would like to conduct a pre-clinical study testing whether infusion of CRHR1 agonists in the septum of Df16(A)+/- mice can rescue social novelty preference and improve social interactions in this model. Our overarching goal is to facilitate the development of new treatments for mental health d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Investigation of the O2-dependent function of HELZ, an RNA helicase interacting with the oxygen-sensing prolyl-4-hydroxylase PHD2'.

assistant: **Innovation**

A crucial step in the adaptation of mammalian cells to oxygen deficiency is the transcriptional activation of hypoxia-inducible genes. Hypoxia-inducible transcription factors (HIFs) are master regulators for the up-regulation of these genes under physiological as well as pathophysiological conditions, such as tumor development and metastasis, cardiovascular diseases and inflammation. HIFs are O2-dependently hydroxylated at conserved prolyl residues by recently discovered prolyl-4-hydroxylase domain proteins (PHDs). Therefore, PHDs function as molecular oxygen sensors by determining the protein stability of HIFα subunits. Importantly, non-HIFα proteins have been reported to represent PHD hydroxylation substrates, indicating that O2-dependent prolyl hydroxylation might be a more common post-translational modification than previously expected. The aim of this grant application is to study the function of the RNA helicase HELZ that was identified to interact with PHD2. HELZ has been shown to be important for the function of SMYD3, a histone lysine methyltransferase which has been implicated in tumorigenesis. Preliminary data demonstrate O2-dependent regulation of HELZ protein abundance and suggest that HELZ might be a novel PHD2 hydroxylation substrate. The goal is to generate a conditional HELZ gene targeting model to characterize the O2-dependent function of HELZ in vivo and to investigate PHD2-dependent HELZ protein hydroxylation by mass spectrometry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Paybon - disrupting the massive global meal voucher market with a smartphone delivery system'.

assistant: **Objectives**

Meal vouchers have become a common part of employee benefit programs, growing to a €59 billion worldwide market annually. To date this market has been dominated by two global providers, Sodexo and Edenred, accounting for approximately 30% of the market each, as well as internal proprietary company solutions and some local providers. Most of the vouchers are still issued in paper form with its numerous disadvantages. The rise of smartphone technology and digital payment systems has created an enormous opportunity to disrupt the meal voucher market. Paybon GmbH, an Austrian-based ICT SME, is exploiting these trends by launching a fully-automated smartphone-based voucher system that boost efficiencies, reduces costs, and creates positive social and environmental impacts. Vouchers can be simply generated by employers and distributed to employees via an web application, and can be redeemed digitally at the point of sale with their smartphones. It is the web-based infrastructure that allows real-time voucher redemption, verification and clearance from phone to phone that is the real and potentially patentable state-of-the-art innovation behind Paybon.As well as convenience, Paybon improves on current solutions by bringing value for money. Paybon attracts employers by proposing up to 50% savings on transaction fees compared to competitive solutions, as well as eliminating budgetary waste from the estimated 10-20% of physical vouchers that expire or are unredeemed. Employees benefit as they can utilize 100% of their allocated voucher, instead of losing portions to changeless systems or through expiration. And restaurants benefit as they are charged just 2-4% transaction fees, compared to the main competitors’ standard 5% rate.Paybon now seeks to launch a feasibility study prove
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NANOCONTAINER-BASED ACTIVE COATINGS FOR MARITIME APPLICATIONS' (NANOMAR), addressing dissemination and exploitation.

assistant: **Impact**

NANOMAR project aims at establishing long-lasting scientific collaboration network between European research institutions and scientists from two BRIC countries, namely Brasil and Russian Federation. The collaboration will be established on the basis of synergisticcombination of the complementary expertises targeting in development of novel “smart” sustainable materials for offshore applications. The collaborative network joints together groups working on development of new functional nanocontainers, novel protective coatings as well asteams holding recognised expertise on the characterization of the anticorrosion coatings.The main scientific objective of the proposal is development of a new generation of “smart” bifunctional coatings that combine the self-healing anticorrosion ability with antifouling properties for offshore applications such as oil-mining platforms and windmill farms. The mainscientific approach on which this project is based is the controlled release of the active species (corrosion inhibitor and biocide agent, respectively) from nanostructured receptacles (nanocontainers) in damaged zones of the coating.The separated specific activities are already ongoing in the individual involved institutions. Therefore the high financial investments are not requested. The extensive exchange of knowledge and expertise on the mutual benefit basis seems to be the most appropriate tool forimplementation of the planned objectives.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Trimeric Bacterial Autotransporters' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Bacterial adhesins play a crucial role in pathogen-host interactions, initiating infections by adhesion to the extracellular matrix and to cell surface proteins prior to invasion. A family of non-fimbrial adhesins, the trimeric autotransporter adhesins (TAAs), has recently been described in gram-negative pathogens. The common biological role of all these TAAs is to mediate the interaction of pathogenic bacteria with their hosts. There is an increasing body of evidence that TAAs represent highly important bacterial pathogenicity factors. Typically TAAs are long, fibrous proteins. They are constructed of a set of repetitive modules or domains that are combined in a fashion of building blocks to meet the individual needs of the pathogen. There is detailed structural and functional information for only a few TAA domains at present. The head domain structure of YadA from Yersinia enterocolitica was solved in Goldman group and motifs were identified that contribute to collagen binding. YadA is an autotransporter, with a globular head, a coiled coil stalk and a C-terminal membrane anchor/translocator. The aim of the proposed project is to: 1. Understand how the β-barrel translolates the passenger domain. 2. Understand the folding mechanism of the β-barrel. 3. Determine the structure of the YadA transmembrane domain in complex with with a collagen peptides.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Support to the Vice-Chair of the ERC Scientific Council 2006-2007' (ERCSC-VICECHAIR-SUP2) under Sixth Framework.

assistant: **Objectives**

In the light of the preparation of future European activities in investigator-driven frontier research through the creation of a European Research Council (ERC), the project aims at supporting and assisting Dr. Daniel Esteve, Vice-Chair of the European Research Council Scientific Council (ERC ScC) in his assignment in order to ensure efficient and smooth operation of the ERC Scientific Council, and the efficient and timely achievement of its objectives in preparing and managing the start of the ERC operations under FP7. The project will provide administrative and secretarial assistance related to the work of the Vice-Chair of the ERC Scientific Council for a period of two years (2006-2008). The total amount of the project is 100.000. The project is hosted by the Commissariat a l'Energie Atomique and includes the appointment of a personal assistant for providing broad administrative and secretarial support to the Vice-Chair of the ScC.  Maintain the calendar and schedule appointments including arranging external meetings  Type, copy and distribute all ERC related documents documents/correspondence/e- mails as needed;  Screen and respond to telephone calls and e-mail;  Serve as host to visitors waiting to speak to ScC Chair  Arrange travel, hotel accommodations, hosting of meals, conference rooms, catering arrangements, etc.  Organise contacts with the ScC secretariat and the secretaries of the ScC (Vice-)Chairs and members;  Establish and Maintain files/archives;  Provide miscellaneous support as needed;  Provide technical assistance to the SCC Vice-Chair in preparation of presentations related to the ERC/ScC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'European Lead-Free Soldering Network'.

assistant: **Concept**

The EU RHS Directive requiring removal of lead hazard from electronics production processes in Europe by 2006 is now in force and is in line with similar initiatives in Japan and the US seeking greater sustainability. The necessary lead-free soldering environmental technology exists and has-been in development for a number of years but now requires urgent research and industry coordination on a pan-European scale in order to support the transformation of European industry and improve competitiveness. Several major EU, Regional and National research projects are underway or proposed and industry implementation has already begun. However the technology is seriously lacking in integration and synergy, particularly with regard to candidate countries, and there is no coherent knowledge base. 'ELFNET - European Lead-Free Soldering Network', is a Coordination Action that will address these problems by using a new organisational model to create a network of 40key partners from across Europe. It is a 3-dimensional structure with recognised Technical Experts from each field, Industry Networks from each sector and National Networks in 19 countries. It will aim to mobilise and optimise the necessary critical mass of research and development in an industry-led initiative and provide vital technology information to each Member State.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Through the looking-glass: investigating the effectiveness of fish condition in mirroring trawling disturbance' under Horizon 2020.

assistant: **Concept**

The evaluation of trawling impact on the productivity of demersal fish species is a crucial knowledge to maintain the yield from wild-capture fisheries and to cope with the global increasing demand of sea proteins. Under this scenario, the study of patterns of trawling disturbance (TD) at relevant scale to provide realistic management strategies will represent a challenge to next generation scientists. TD generates a multi-faced combination of direct (e.g. displacement of population structure of commercial species targets) and indirect (e.g. food-web alteration) effects contributing to the likelihood of resource limitation and hence stability of the whole marine ecosystem. The indirect effects are still understudied. It remains still largely unknown how the alteration of benthic dynamics due to chronic trawling disturbance can trigger unpredictable cascade effects involving most ecological components impairing the system to cope with the natural environmental variability. MIRROR aims to investigate the TD effects on the diet and condition of a target species (Mullus barbatus) in the Western Mediterranean Sea through the mechanisms of competitor and benthic prey reduction by the fishing activity. MIRROR will explore the effects that changes in fish condition can have on life-history traits (e.g. growth and reproductive potential). Understanding the link between TD, condition and LH traits represents a stepping stone for the inclusion of condition as an indicator for the management of exploited species. MIRROR’s outcomes may allow the identification of TD thresholds to achieve a desired mean optimal condition. The integration of results will be used to inform stakeholders and policy makers suggesting measures to promote a sustainable fishery by minimizing impacts and ensu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CRESCINE – INCREASING THE INTERNATIONAL COMPETITIVENESS OF THE FILM INDUSTRY IN SMALL EUROPEAN MARKETS' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

CRESCINE’s mission is to increase the competitiveness of the film industry across small countries in Europe and improve the circulation of films and AV content coming from small markets internationally. CRESCINE’s aims to enhance the competitiveness and the cultural diversity of the European film industry. This will be achieved by understanding, engaging with, empowering, and ultimately transform European small markets setting out from research and piloting in 7 markets.  In their “smallness"", these markets underline the challenges and drivers one must consider to increase the competitiveness of the EU film industry as all. CRESCINE will address, systematically, the whole film production, distribution and consumption ecosystem. The aim is to innovate at all levels of the value chain, from policies to ways of data management and analytics, production business models and modes of distribution. CRESCINE will develop novel tools, methods, and strategic approaches that all build on the concept of smallness and the positive affordances it entails for the overall competitiveness of the European film industry. CRESCINE will address all expected outcomes of the call through the lens of exemplary European Small Film Markets which stand for the majority of film markets in the European Union. CRESCINE will establish an innovative model of analysis and evidence collection across the value chain that is framed by cutting edge data analytical models, comparative benchmarks promulgated in light of best available evidence including unprecedented data sources. The findings will lead to work on innovative solutions and testing of new tools, policies, business models or financing schemes, and green strategies. These activities feed the overall impact of the project and its ability to prod