RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Human model for safety two'.

assistant: **Objectives**

The development of transport passive safety measures needs tools capable of predicting the injury risk of potential victims. Present tools (dummies) are limited in bio fidelity and application. The objective of this project is to develop human body numerical models representing a large range of the European population and allowing an accurate injury risk prediction. For that, an anthropometric database, a scaling tool and a positioning tool will be created to obtain the meshes of the 5th, 50th, 95th percentiles body in driving and standing positions. Data concerning muscle tone effect, soft tissues mechanical properties, internal organ interactions, injury mechanisms and whole body response to impact will be acquired. These biomechanical data will be stored in a database to be used to develop and validate the models. After validation, the capability of the developed models for injury prediction will be assessed in realistic impact situations including different transport modes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Design and Manufacturing of Catalytic Membrane Reactors by developing new nano-architectured catalytic and selective membrane materials' under Seventh Framework.

assistant: **Concept**

The DEMCAMER project proposes an answer to the paradigm met by the European Chemical Industry: increase the production rate while keeping the same products quality and reducing both production costs and environmental impacts. Through the implementation of a novel process intensification approach consisting on the combination of reaction and separation in a “Catalytic Membrane Reactor” single unit.The aim of DEMCAMER project is to develop innovative multifunctional Catalytic Membrane Reactors (CMR) based on new nano-architectured catalysts and selective membranes materials to improve their performance, cost effectiveness (i.e.; reducing the number of steps) and sustainability (lower environmental impact and use of new raw materials) over four selected chemical processes ((Autothermal Reforming (ATR), Fischer-Tropsch (FTS), Water Gas Shift (WGS), and Oxidative Coupling of Methane (OCM)) for pure hydrogen, liquid hydrocarbons and ethylene production.The DEMCAMER scheduled workplan will comprise activities related to the whole product chain: i.e. development of materials/components (membranes, supports, seals, catalyst,..) through integration/validation at lab-scale, until development/validation of four pilot scale CMRs prototypes. Additionally, three research lines dealing with: 1) the collection of specifications and requirements, 2) modelling and simulation of the developed materials and processes, and 3) assessment of environmental, health & safety issues -in relation to the new intensified chemical processes- will be carried out..For a maximum impact on the European industry this research, covering the complete value chain of catalytic membrane reactors, can only be carried out with a multidisciplinary and complementary team having the right expertise, including top le
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Definiton and development of functional barriers for the use of recycled materials in multilayer food packaging'.

assistant: **Objectives**

BANUS project aims to develop new multilayer structures for food packaging applications, in order to evaluate their properties as functional barriers, using conventional polymers to achieve new functionalities and open new potential markets for the traditional recycling companies in Europe.Taking into account that the main objective of the project is to guarantee the suitability of the developed functional barrier layers, it is necessary to check that, independently of the quality of the used recycled material, the functional barrier is able to avoid any migration of contaminants to food. A great advantage of BANUS approach is to be able to guarantee food safety when using recycled materials (plastic and paper) even coming from non-authorized recycling processes in food packaging structures.The project will consider the substitution of a percentage of virgin material by recycled material (paper or plastic) in the selected structures in order to develop more environmental friendly food packaging structures. As the main requirement of food packages is always to guarantee food safety for consumers, this substitution will be achieved after evaluating the functional barriers positioned between recycled layers and foodstuffs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'POLARIN: POLAR RESEARCH INFRASTRUCTURE NETWORK' (POLARIN) under Horizon Europe.

assistant: **Objectives**

The polar regions play a key role in the Earth’s system. They are essential for our climate and are sentinels of climate change, human expansion, and the hunt of new resources. The polar regions are losing ice, and their oceans and land are changing rapidly. The consequences of this polar transition extend to the whole planet and are affecting people in multiple ways. Evidence-based policy recommendations are needed, but the polar regions are difficult to reach, and research infrastructures able to operate in these regions are scarce. To understand and predict key processes in the polar regions and provide evidence-based information, the polar research community needs access to world-class research infrastructure operating in these regions.POLARIN is an international network of polar research infrastructures and their services, aiming at addressing the scientific challenges of the polar regions. The network includes a wide array of complementary and interdisciplinary top level research infrastructures: Arctic and Antarctic research stations, research vessels and icebreakers operating at both poles, observatories, data infrastructures and ice and sediment core repositories. POLARIN will provide integrated, challenge-driven, and combined access to these infrastructures to facilitate interdisciplinary research on complex processes. POLARIN will:1.Provide challenge-driven transnational access to a large portfolio of research infrastructures. 2.Improve the access to data by improving data availability and interoperability between data infrastructures. 3.Provide virtual access to data and data services. 4.Provide data products for the scientific community and decision makers.5.Train the young generation of polar researchers in optimally exploiting the infrastructures for thei
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Risk assessment of wood dust: assessment of exposure, health effects and biological mechanisms' (WOOD-RISK), addressing dissemination and exploitation.

assistant: **Impact**

The goal of this proposal is to provide accurate, up-to-date data on occupational exposure to wood dust, and to assess associations between such exposure and molecular alterations of Sino-nasal cancers, and biological mechanisms of pulmonary inflammation. Data on overall levels of European exposure will be obtained from European exposure databases and exposure registers as well as by monitoring wood dust levels in workplaces. Sino-nasal cancer cases and their exposure histories will be collected and paraffin-embedded tissue samples examined for p53 and K-transmutations. DNA damage induced by wood dust will be studied in exposed human cells. Molecular mechanisms of wood dust-induced pulmonary inflammation will be studied with experimental animals and cell cultures, and with nasal epithelial cells obtained from wood dust exposed subjects. Data from exposure assessment and the toxicological endpoints will be compiled for risk assessment. The study ultimately aims to provide exposure and mechanism-bases data for setting occupational limit values to improve safety at workplaces.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Development of murine transgenic systems for the experimental study of tumour initiation, progression and treatment - Animal models of human cancers'.

assistant: **Concept**

Experimental carcinogenesis has, until recently, relied on the use of animal models in which the tumourgenic process is distantly related to that observed in humans. More recently, the use of transgenic mice hemizygous for a tumour suppressor gene has opened new opportunities but has also revealed two limitations : first some of the most prominent tumours observed in genetically predisposed humans are not observed in the corresponding mice (retinoblastoma is not observed in mice hemizygous for Rb); second for most instances (with the notable exception of p53) mice homozygously inactivated for a tumour suppressor gene are not viable. We propose to overcome these difficulties by the development of a modular transgenic mouse system which should enable the appearance of defined somatic mutations in a tissue specific manner. This system is based on the use of the Cre recombinase which directs recombination between two small oligonucleotidic target sequences called Lox. Recombination between two Lox sites in a direct (head-to-tail) orientation causes excision of the intervening DNA. This principle can be used to inactivate a tumour suppressor by inducing the deletion of a critical exon. The production of 4 series of conditional mutants which will target either Rb or TP53 or APC or NF2 is proposed. The use of transgenic constructs in which the Cre recombinase is placed under tissue specific promoters should enable to restrict the Cre expression to a relevant tissue (i.e. to the retina for a conditional Rb mutant). An additional degree of sophistication is proposed which will enable to trigger the creation of defined somatic mutation not only in a tissue specific manner but also at a time that is decided by the investigator. This approach is made possible by the development of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation of somatic suicide gene therapy approaches in the management of leukaemia: in vitro and in vivo approaches' (1994-1998).

assistant: **Concept**

- Optimisation of retroviral suicide gene vectors and prodrug activation strategies. - Investigation of novel vectors for somatic SGT. - Testing of suicide gene/prodrug activation strategies in animal models of graft versus host (GvH) and graft versus leukaemia (GvL). - Establishment of the requirements to prevent an immune response against the suicide gene vector. - Molecular evaluation of the efficacy of SGT strategies in animal models.The objective of this project is to develop somatic gene therapy approaches for treating disseminated malignant diseases such as leukaemia. To achieve this objective, a somatic suicide gene therapy/prodrug activation strategy will be undertaken. Allogeneic stem cell transplantation (SCT) is a highly successful treatment modality for leukaemia, partly due to the anti-tumour activity of donor T cells in the graft. However disease relapse is a significant problem. Allied to the graft versus leukaemia (GvL) effect in SCT, donor T cells also mediate graft versus host disease (GvHD) leading to a reduction in long term survival. In this study somatic suicide gene therapy strategies will be evaluated for their ability to enhance tumour cell killing by allogeneic donor T cells without increasing GvHD. Retroviral vectors containing the herpes simplex thymidine kinase (HSV-Tk) gene or the cytosine deaminase (CD) gene will be evaluated for their ability to transduce donor T cells with high efficiency. New vectors will be developed using selectable markers that allow immunoaffinity selection. In addition adeno-associated viral vectors containing prodrug gene constructs will be examined for their potential as suicide gene therapy vectors. For all vectors conditions will be established for optimal transduction, selection and expansion of transduced an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-Throughput Quantum Chip Diagnostics' (HTQC-Diagnostics).

assistant: **Concept**

Computing power has grown exponentially for decades closely following Moore’s law but progress is slowing down and it is time for new ideas. Quantum computers based on qubits can extend the realm of possibilities unavailable to conventional computers based on bits. The market opportunity for quantum computers is huge, but the tools to transition from academic research to industry-grade quantum chip development are lacking. For example, diagnosing the quality of a quantum chip requires months of work by highly specialized quantum engineers in a full cryogenic lab. We are revolutionizing this practice with our Orange Quantum Diagnostics Systems. Once a quantum chip is fabricated, you just insert it, and the system will run a comprehensive set of proprietary diagnostic protocols to ensure deployment readiness. Our solution is fully automated and orders of magnitude faster than standard practices. With the EIC support, we will trigger Moore's law scaling for quantum computers.


**Keywords:** Quantum technology,Quantum computing,Machine learning, statistical data processing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reverse transcription with electrically stretched mrna' in the context of a Fifth Framework call.

assistant: **Objectives**

The 'reverse transcription' is crucial for genetics, cancer research, virology, etc. The efficiency ispoor because the corresponding molecules (mina) are folded. Stretching the mina with appropriate electrical fields can remove this obstacle. The 'reverse transcription' is crucial for genetics, cancer research, virology, etc. The efficiency ispoor because the corresponding molecules (mina) are folded. Stretching the mina with appropriate electrical fields can remove this obstacle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Reasoning About Strategic Interaction and Emotions' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

I propose to develop a general framework to analyze the dynamics of social and economic interaction between intelligent agents, who may nonetheless be affected by their emotions and exhibit time inconsistent preferences. A crucial aspect of the analysis is modelling how agents form and change their beliefs about the environment and about each other, including beliefs about beliefs. The reason is twofold; first, in order to reason strategically, agents try to figure out how other agents think; second, emotions triggered by beliefs, including beliefs about the beliefs and intentions of other agents, may affect choice. Another essential ingredient is the impossibility to commit (even covertly) to any particular contingent course of action, unless such irreversible commitment is allowed by the rules of the game. Intelligent agents with non-Bayesian attitudes toward uncertainty, disappointment aversion, present-bias, and other realistic psychological features should take this into account when planning. This leads to a distinction between actual behaviour and plans, which is essential to express the concept of intentionality and hence the ability to assess the intentionality of other agents’ observed actions. Such assessment is important to figure out the likely future moves of a co-player in a game, or his private information, as well as for the cognitive appraisal that may affect emotional reactions to positive or aversive events in social and economic environments.Developing such methodology is one part of the project of independent interest. Next, I plan to apply it to specific problems such as the analysis of (i) learning and stable patterns of behaviour when agents are ambiguity averse, (ii) the sources and consequences of emotions like anger in social environments, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development and characterization of a pan-flavivirus vaccine candidate' (FLAVIVACCINE).

assistant: **Concept**

Dengue, yellow fever, Zika, and West Nile viruses are mosquito-borne flaviviruses and global public health burdens that infect half a billion people annually, causing 250,000 deaths, and threaten nearly the entire human population. In a context of human-driven global changes, these threats will intensify with larger and more frequent epidemics, potentially leading to pandemics, will expand with geographic spreading of the mosquito vectors, and will multiply with the likely emergence of yet-unknown flaviviruses. Improving pandemic preparedness and response to these emerging and re-emerging diseases is a top priority both for the EU and WHO. However, there are no effective interventions against all flaviviruses and current vaccines targeting flaviviral proteins have severe safety issues. FLAVIVACCINE’s high-impact/low-risk/disruptive ambition is to develop a novel, broad-spectrum, mosquito saliva-targeted vaccine candidate that protects against multiple different flaviviruses and is ready for clinical evaluation by building upon an experimentally-validated proof-of-concept. FLAVIVACCINE will define the immunogenicity of the pan-flavivirus target, develop and characterize a vaccine candidate against multiple flaviviruses, and prepare it for clinical evaluation. To reach these goals, FLAVIVACCINE creates a unique interdisciplinary environment of ten public and private institutions, including Universities, Research Institutions and a Vaccine Developer, from seven countries to cover all the required scientific expertise and knowledge in cell biology, virology, immunology and vaccinology. The pan-flavivirus vaccine candidate that will be validated against dengue, yellow fever, Zika and West Nile diseases in several preclinical models, together with the knowledge and networks r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of new Competitive and Sustainable Bio-Based Plastics' in the context of a Horizon 2020 call.

assistant: **Objectives**

The objective of NEWPACK is to validate in industrial setting the production of at least two new bio-plastics based on PHB- PLA blends with improved sustainability performance, obtained by the addition of natural extracts with antioxidant/antibacterial properties and nanoadditives from cellulose and chitin. A new circular economy value chain will be generated from agro-food wastes that will be exploited for the production of PHB, while designing and validating the process up to pilot scale. Blending of PLA and PHB will be validated at pilot scale to achieve specific final product requirements based on targeted products. New bioplastic properties and functionalities will be achieved through incorporation of nanocellulose or nanochitin additives (to improve typical problems of processability and mechanical properties of PLA-PHB), antioxidant and antimicrobial additives. The ability to extend the functionalities will be validated in real industrial environments. NEWPACK activities are underpinned by the prior experience and results (already validated at TRL 3-4) of the partners in order to achieve advanced TRLs (5-6) for the developed technologies, including PHB production from agro-food waste; co-blending of PHB with PLA; nanocellulose extraction from wheat straw and incorporation into PHB-PLA blends and encapsulation of natural antioxidants/antimicrobials for addition to PHB-PLA. Great emphasis will be on assessing technical and economic feasibility of the processes; demonstrating the biodegradability of solutions; ensuring the compliance to the market and regulatory requirements; LCA evaluation;  preparing for future scale-up of the processes to achieve a pre-industrial production and identification of stakeholders perceptions, attitudes and expectations towards bioplas