RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The Integrated Initiative of European Laser Research Infrastructures' (LASERLAB-EUROPE) targeting Horizon 2020.

assistant: **Abstract**

LASERLAB-EUROPE is the European consortium of major national laser research infrastructures, covering advanced laser science and applications in most domains of research and technology, with particular emphasis on areas with high industrial and social impact, such as bio- and nanophotonics, material analyses, biology and medicine. Recently the field of advanced lasers has experienced remarkable advances and breakthroughs in laser technologies and novel applications. Laser technology is a key innovation driver for highly varied applications and products in many areas of modern society, thereby substantially contributing to economic growth. Through its strategic approach, LASERLAB-EUROPE aims to strengthen Europe’s leading position and competitiveness in this key area. It facilitates the coordination of laser research activities within the European Research Area by integrating major facilities in most European member states with a long-term perspective and providing concerted and efficient services to researchers in science and industry.The main objectives of LASERLAB-EUROPE are to:•promote, in a coordinated way and on a European scale, the use of advanced lasers and laser-based technologies for research and innovation, •serve a cross-disciplinary user community, from academia as well as from industry, by providing access to a comprehensive set of advanced key laser research installations,•increase the European basis of human resources in the field of lasers by training new users, including users in new domains of science and technology and from geographical regions of Europe where laser user communities are still less developed,  •improve human and technical resources through technology exchange and sharing of expertise among laser experts and operators across Europe, an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'A novel hardware & software platform to revolutionise artificial intelligence at the edge'.

assistant: **Objectives**

Our solution is a hardware (HW) and software (SW) platform optimized for inference at the edge, which, as a market, is projected to grow exponentially, and to reach €15.52 B in 2025. Our solution will accelerate the latest generation of neural network models for computer vision, natural language processing and generative AI to revolutionize the way we use AI, at a fraction of the costs and power consumption of available solutions. The HW will be available in various form factors for rapid adoption and is highly scalable–from a single device running in an embedded system to multiple instances on cards in an edge datacenter. Our SW tools provide a consistent, powerful and easy-to-use development environment for all of these instances, while driving the adoption of AI through our no-code web composer. We have a strong team led by the CEO who was the Head of Artificial Intelligence at Bitfury and has 20+ years of managerial experience in tech corporations such as Asus and Advantech.


**Keywords:** Natural Language Processing, Generative AI, RISC-V
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dynamics and Self-organisation in Complex Cytoskeletal Networks', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The requirements on the eukaryotic cytoskeleton are not only of high complexity, but include demands that are actually contradictory in the first place: While the dynamic character of cytoskeletal structures is essential for the motility of cells, their ability for morphological reorganisations and cell division, the structural integrity of cells relies on the stability of cytoskeletal structures. From a biophysical point of view, this dynamic structure formation and stabilization stems from a self-organisation process that is tightly controlled by the simultaneous and competing function of a plethora of actin binding proteins (ABPs). To understand the self-organisation phenomena observed in the cytoskeleton it is therefore indispensable to first shed light on the functional role of ABPs and their underlying molecular mechanisms. Hereby development of reliable reconstituted model systems as has been proven by the great progress achieved in our understanding of individual crosslinking proteins that turn the cytoskeleton into a viscoelastic physical gel. The advantage of such reconstituted systems is that the biological complexity is decreased to an accessible level that the physical principles can be explored and identified.It is the aim of the present proposal to successively increase the complexity in a well defined manner to further progress in understanding the functional units of a cell. On the way to a sound physical understanding of cellular self organizing principles, the planned major step comprises the incorporation of active processes like the active (de-)polymerisation of filaments and motor mediated active reorganisation and contraction.  We plan to develop new tools and approaches to address how the different kinds of ABPs are interacting with each other an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification of the mechanisms by which Helicobacter induces intestinal inflammation' (2002-2006).

assistant: **Concept**

Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a significant health concern in the developed world, and the number of affected individuals is on the rise in both Europe and the USA. The cause of IBD is not known; however, the intestinal bacterial flora and an inappropriate (pathogenic") immune response to these bacteria are believed to contribute to the onset of disease. Despite available treatments for humans with IBD (medications, nutritional therapies, and surgery) there are many patients for whom these therapies are not effective. Thus, increased knowledge of the interactions between intestinal bacteria and the immune system in individuals with and without disease is of utmost importance as such information m ay aid in the development of new therapies for IBD.This project aims to identify the mechanisms by which bacteria trigger intestinal inflammation in disease-susceptible individuals. Using an experimental model of IBD involving infection with Helicobacter hepaticus, we will focus on the initial encounter between bacteria and cells of the innate immune system and examine how these interactions lead to the development of a pathogenic T cell response and subsequently disease. The two specific objectives of this proposal are to explore the mechanism by which H. hepaticus activates cells of the innate immune system, and to identify the anatomical location where priming of disease-inducing T cells occurs. These objectives will be achieved using cellular immunology methods and a newly developed transgenic mouse model incorporating the T cell receptor of a disease-inducing T cell clone directed against a defined protein of H. hepaticus.The proposed project is likely to provide new insights into the mechanisms underlying the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'EDV2209 – a Paradigm shift in the treatment of stroke.' (EDVance).

assistant: **Innovation**

Despite tremendous research efforts and a large number of clinical trials focused on developing treatments for stroke, the field's current state remains dismal. There are, at present, no efficient treatments nor promising drug candidates for this lethal and disabling condition. A different perspective with a new approach is therefore desperately needed. Edvince's drug discovery and development is born out of founder and Professor Lars Edvinsson's extensive, fundamental and pioneering research of cerebral circulation, receptor regulation, stroke and migraines. Edvince is now ready to conduct the first clinical trial in 2022 with its innovative and disruptive lead drug EDV2209, an orphan drug for the treatment of brain ischemia associated with severe subarachnoid hemorrhage (SAH). The drug helps to keep the blood vessels in the brain open, allowing brain cells to receive oxygen and nutrients to prevent brain damage.


**Keywords:** Stroke,Clinical trials,Subarachnoid hemorrhage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Durability and reliability of railway wheel sets (TRANSMEC)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Project goal is to set up Centre of Excellence TRANSMEC, doing research/education work related to rail transport, and in particular to wheel sets issues. It is propose to strengthen existing and establish new contacts the leading universities and research centres abroad. Some of proposed activities are: - International scientific and educational co-operation - organising conferences and workshops- participating in joint European research projects - disseminating research results- enabling flow of information between research centres from NAS and EU- promoting new research management methods- providing more attractive educational opportunities (post-graduate studies and training courses for industry workers and junior scientists) - developing new teaching/research procedures - supporting and promoting participation of industrial companies and SMEs in international research projects - harmonising NAS regulations on railway wheel sets with EU standards - dissemination of information on the Centre. Expected project result- Initiating and strengthening international co-operation within scope of European Research Area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rewire the lymph node niche to instruct T cell immunity' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Lymph nodes (LN) are communication centers within the lymphatic network that instruct T cell priming and differentiation in homeostasis and disease. Multiple layers of control are achieved by a complex network of signals from stromal and immune cell compartments. As a result, spatially segregated LN niches coexist that foster diverse T cell lineages. In the context of cancer, T cell differentiation is pushed towards the lineage of exhaustion, with a progenitor exhausted T cell population arising in the LN. Hence, LN are central anatomic sites where T cell exhaustion can be controlled and reversed to eliminate cancer. The key question of REWIRE is: What microenvironmental factors determine the differentiation and maintenance of progenitor exhausted T cells in the LN?Tumor-derived signals reprogram stromal and immune cells within tumor-draining LN. Thus, a premetastatic niche is formed that supports future metastatic seeding while establishing an immunosuppressive microenvironment. I hypothesize that signals guiding T cell differentiation are altered by premetastatic remodeling of the LN niche, resulting in the generation of exhausted T cells.In this project, I aim to (1) decode spatial determinants of the progenitor exhausted T cell niche; and to (2) manipulate the tumor-draining LN ecosystem to control T cell immunity. The overarching goal is to dissect how tissue architecture directs molecular responses within the LN niche to regulate T cell exhaustion. We will use high-dimensional imaging technologies to chart the spatial context of progenitor exhausted T cells following tumor progression; as well as a novel myeloid cell-based in vivo delivery platform to specifically target tumor-draining LN.REWIRE will uncover basic mechanisms of communication between the LN microen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanopatterning, Production and Applications based on Nanoimprinting Lithography' (NAPANIL), addressing dissemination and exploitation.

assistant: **Impact**

The NaPANIL project aims to develop processes, materials and tools, both for manufacturing and for control, for truly 3-dimensional nanosurfaces with feature dimensions ranging from 50 nm to several m. The nanosurfaces will be realised using various variants of nanoimprinting lithography. The dedicated application is to control light at nanostructured surfaces and a few potential high impact products have been identified by the end-user partners in the consortium. Design, demonstration and prototyping these applications will act as test-bench for the new manufacturing paradigm. The manufacturing processes possess generic aspects for production of any kind of topographically 3-dimensional nanostructured surfaces. In the R&D of nanoimprinting Europe has a leading position. The NaPANIL consortium combines the best expertise and know how in field to reach the goals in the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Studying the physics of exceptional points using metamaterials' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Metamaterials is a new class of materials constructed from artificial atoms with their optical properties often come from the underlying structures instead of the composing materials. They can therefore be flexibly designed to achieve particular optical functions. As a result, extreme functions like invisibility cloaking and subwavelength imaging become possible. Because of this extreme flexibility, metamaterials can also be used as a platform to study the physics of waves in general and this is the main theme of this proposal. In particular, we are interested to use metamaterials to study the physics of exceptional points, which is tightly linked to various extraordinary wave phenomena including unidirectional reflection, phase transition, anti-lasing and non-reciprocal propagation. Moreover, exceptional points can also give us high sensitivity, which can be important for future applications of metamaterials in order to give reconfigurable or tunable metamaterials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Heterogenous biocatalytic reaction cascades training network' to be submitted under Horizon 2020.

assistant: **Abstract**

The INTERfaces program will train 14 ESRs within an EID network jointly designed by European academic and industry partners in innovative research projects dedicated to developing clean bioprocesses for the production of chemicals. The assembly of biocatalysts to reaction sequences allows avoiding steps for isolation and purification of intermediates and thus a significant improvement of the environmental footprint of catalytic processes. The main goal of INTERfaces is the extension of this concept towards multi-step biocatalytic reactions in immobilized form. These “Heterogeneous Biocatalytic Reaction Cascades” will greatly facilitate re-use of the catalysts and further simplify downstream-processing. INTERfaces combines material science and protein engineering to design tailored enzymes and (bio-based) materials that will complement each other to obtain optimized heterogeneous biocatalysts. These tools will be applied to solve synthetic challenges in the use of two biobased monomers as starting materials to synthesize products for application fields like antioxidants and biopolymers. Process optimization and up-scale in industry will reveal key factors for synthetic utilization of the biocatalysts. INTERfaces emphasizes particularly the engineering of the designed cascades in solid phase. This includes the design of reactors, use of computational modeling tools, application of the right operational modes, and reaction medium needed for desired space-time-yields and product titers. Commercial relevant processes will be up-scaled together with industry for technical implementation. 13 Non-academic partners ranging from high-tech SMEs to large producing companies and 9 academic institutions offer an intersectoral and interdisciplinary environment to provide 14 Ph.D. cand
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A dynamical view of binding affinity' (BAP), addressing dissemination and exploitation.

assistant: **Impact**

Almost all critical functions in the cell rely on specific protein-protein interactions (PPIs). Understanding interactions is therefore a crucial step in the investigation of biological systems and in drug design. Despite all the research efforts that have been devoted to unravel principles of PPIs in the past decades, we still lack a thorough understanding of the energetics of proteins association, which is limiting our ability to consistently predict protein complexes, engineer high-affinity interactions and design new drugs. An improved understanding of protein binding affinity holds the key for resolving some of the most important problems in molecular biology, with wide implications in related fields. In this project I propose a novel approach to reliably predict the binding affinity by adding the so-far neglected dynamical dimension to the problem. Unlike traditional methods like empirical energy-based scoring, I will assess the conservation of interface contacts in protein complexes during dynamics trajectories. By correlating such properties to experimental binding affinities, a new predictor will be developed. Preliminary results on limited set of complexes already indicate that this approach has a great potential, outperforming any predictor proposed to date. Moreover, I will expand this novel approach and assess its applicability to other critical research fields related to biomolecular interactions, such as docking and proteins and interactions engineering. This project will allow me to reinforce and further expand my skills and expertise, create new collaborations and reinforce my position as researcher in Europe, which will enable me to reach full independency in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'New Road Construction Concept (NR2C)'.

assistant: **Innovation**

European countries contain a large amount of surface transport infrastructure, which sometimes appears inappropriate to meet societal demands.Road-building techniques have developed slowly, due to a limited number of significant technical breakthroughs, poor coordination among stakeholders and a focus directed primarily on resolving current problems.No global European road concept has yet come to the fore; the upcoming enlargement of the European Union should heighten the acute need for a sustainable integrated European surface transport network.Road-related budgets have been steadily decreasing while user expectations become more demanding and contradictory: increased transit capacities, higher safety levels, pollution mitigation (sound, air), aesthetic integration. Creating a global vision for the road of the future and confronting both technological and societal problems within a single research process have thus taken on urgency; such is the objective behind the NR2C proposal. Based on a large survey among road stakeholders, this project is aimed at selecting safe, environment-friendly and subtle concepts in order to strike a compromise between reduced global construction/maintenance costs, safety and environmental criteria.A number of innovations targeted for different social and geographical environments will be selected to achieve pilot applications in support of a long-term perspective. NR2C will consider urban and interurban areas as well as needs specific to Western and Central Europe;bridges, considered as single network nodes,will be studied separately. FEHRL(Forum of European National Highway Research Laboratories)will perform a decisive clustering role in addition to conducting major dissemination actions.Moreover, the management function will be given spe