RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PAINTing the architecture of the totipotency gene network during early mammalian development' (EmbryoPAINT).

assistant: **Concept**

The three-dimensional architecture of the genome regulates its fundamental functions such as the transcription or replication of DNA. Thus, chromatin organisation is crucially important for key aspects of cell biology, such as the differentiation of stem cells in the early embryo. While recent studies have shown that the mammalian genome rearranges extensively towards a more ordered state after the first few embryonal divisions, many fundamental questions remain unanswered. For example, it is not known whether totipotent cells have a well-defined genomic architecture or whether this architecture is highly heterogeneous between different cells and embryos. Further, it is unclear if early cell fate decisions are driven by a reproducible coordinated rearrangement of pluripotency-related genes, or if this is stochastic process. These questions could best be tackled by directly assessing the physical genome structure and architecture of pluripotency genes in single stem cells inside the whole embryo. In my project, I will pursue this ambitious aim by exploiting recent breakthroughs in 3D super-resolution microscopy, namely the development of an inverted lattice light-sheet microscope, highly multiplexed oligo-DNA-PAINT, and advanced computational algorithms, to study the physical 3D architecture of the genomic network of totipotency and pluripotency genes.  Thus, I will for the first time be able to unravel the structural determinants of the transition from totipotency to the pluripotent and differentiated state during early mammalian development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Disseminating tumor cells as novel biomarkers: Dissecting the metastatic cascade in cancer patients' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Breast, prostate, lung and colorectal cancer as solid tumours derived from epithelial tissues are responsible for 90% of all new cancers in Europe. Present tumour staging is mainly based on local tumour extension, metastatic lymph node involvement and evidence of overt distant metastasis obtained by imaging technologies. However, these staging procedures are not sensitive enough to detect early tumour cell dissemination as a key event in tumour progression. Our team has therefore focused on the development of ultrasensitive assays that allow the specific detection and molecular characterization of single tumour cells in bone marrow (DTC) and blood (CTC) of cancer patients. These methods allow the direct assessment of disseminating tumour cells including the detection of therapeutic targets and mechanisms of resistance in patients undergoing therapy. Based on our established network of clinical collaborations, the DISSECT project will detect and characterize DTC/CTC in patients with the four most frequent tumour entities in the EU by high resolution methods. We will investigate representative clinical studies for current interventions that may have an impact on tumour cell dissemination, including diagnostic biopsies, surgical resection of the primary tumour, radiotherapy, chemotherapy and in particular targeted therapies. The technologies for DTC/CTC analyses previously developed by our team will be complemented by cutting-edge technologies and adapted to the analysis to decisive molecular processes underlying the particular intervention. The results obtained in the DISSECT project will provide unique insights into the biology of tumour cell spread in humans and these insights might lead to improved concepts in the clinical management of cancer patients.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Priming protective mhc class i-restricted t cell immunity by novel vaccine delivery strategies that target alternative epitope repertoires' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Specific stimulation of MHC class I-restricted cytotoxic T lymphocytes (CTL) responses is a key objective for vaccines against intracellular infections. Epitope repertoires (ER) recognized by CTL are generated by processing antigen in proteasome/TAP-dependent (ER^prot) and alternative proteasome/ TAP-independent (ER^alt) pathways. Many new vaccination strategies prime CTL to alternatively pro-cessed antigens. The consortium targets the analysis of alternative processing of vaccine-relevant antigens from HCV, HBV and malaria plasmodia resulting in peptides for human/murine MHC class I presentation. It will be tested if CTL populations specific for the ER^alt alone, or in combination with CTL recognizing the ER^prot are associated with protection against natural human HBV, HCV and plasmodium infections. The insight into alternative processing will be used to design and test optimised safe vaccines that induce broad CTL immunity also to the ER^alt.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Commercially empowered Linked Open Data Ecosystems in Research'.

assistant: **Concept**

Linked Open Data (LOD) shows enormous potential in becoming the next big evolutionary step of the WWW. However, this potential remains largely untapped due to missing usage and monetisation strategies.CODE's vision is to establish the foundation for a web-based, commercially oriented ecosystem for Linked Open Data. This ecosystem establishes a sustainable and commercial value-creation-chain among traditional (e.g. data provider and consumer) and non-traditional (e.g. data analyst) roles in data marketplaces. Monetary incentives will motivate people to analyse, organise and integrate LOD with unstructured information sources thereby increasing data quality and quantity.Our use-case focuses on research papers as a source for mining facts and their integration into LOD repositories and light-weight ontologies. Hence, we will leverage the wealth of knowledge contained in research publications on a semantic, machine-readable level by creating the Linked Science Data cloud. This cloud will have an impact on innovation driven businesses by making scientific knowledge more accessible and transparent.Therefore, we will research and develop:1.crowd-sourcing enabled semantic enrichment & integration techniques for integrating facts contained in unstructured information into the LOD cloud2.federated, provenance-enabled querying methods for fact discovery in LOD repositories3.web-based visual analysis interfaces to support human based analysis, integration and organisation of facts4.socio-economic factors - roles, revenue-models and value chains - realisable in the envisioned ecosystem.The consortium brings together high-potential partners, providing the necessary resources for realizing our vision: tera-bytes of research publications, millions of light-weight ontologies, a steadily
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Novel methods to preserve specialized bacteria for biodegradation of complex industrial wastewaters' in the context of a Sixth Framework call.

assistant: **Objectives**

The main goal of this project is to develop innovative technologies to enhance growth and survival of diverse bacterial communities capable of degrading complex industrial wastes, in bioreactors designed for that purpose. We will focus on the microbial ecology of complex waste streams generated by the chemical industry, and will place emphasis on means to enable efficient and secured application of biological processes.Three different methods to increase biomass preservation in bioreactors will be tested and compared (namely, encapsulation, immobilization, and enhanced bio-flocculation and co-flocculation). The transfer of knowledge in this project involves the collaboration of two intellectual properties and know-how, one academic (BGU, Israel) and one SME (BIOCONS, Germany). It will be based on continuous cooperation and knowledge transfer between the two senior Israeli partners and the German senior partner. A dedicated researcher (post-doc) will be recruited by the Israeli partner to strengthen the connection by frequent travels between the two locations.The project is aimed at solving a major problem faced by many EC member states or associated states. BIOCONS will gain unique practical knowledge based on deep scientific and analytical tools. This will enable application of superior technologies to prevent ecological damage and health hazards. Since the EU views the accumulation of wastes in the environment as a major threat to future developments, the knowledge produced and transferred through the current project will contribute directly to the concept of sustainable development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Role of Mitochondrial Physiology in Tumor Stem Cell Resistance to Chemotherapeutics' (MITOCANCERSTEM).

assistant: **Concept**

Although many advances in cancer research have heightened cases of long term survival, tumor re-growth is still a major concern. One hypothesis of the driving force behind tumor re-growth is the subpopulation of cancer stem cells found in varying types of tumors. Cancer stem cells have emerged as an important chemotherapeutic target over the past decade, as their ability to evade treatments provides a likely source for tumor re-growth. Like organs, tumors are composed of a mixture of cells at varying states of differentiation and arise from cells with the ability to proliferate indefinitely and differentiate into multiple lineages. In healthy organs, the cells responsible for organ development are stem cells, suggesting that tumors also have a subset of cells with stem-like characteristics known as cancer stem cells. Over the past decade, support for the existence of cancer stem cells has grown, suggesting that cancer stem cells are a driving force in tumorigenesis.This project is devised to investigate mitochondrial characteristics of cancer stem cells that allow them to survive the effects of chemotherapeutic drugs, especially those targeting apoptotic pathways. Our working hypothesis will be that the differential physiology of mitochondria in tumor stem cells and differentiated cells result into a different susceptibility to chemotherapeutics.To pursue the objective of the present work we will use mouse P19 embryonal carcinoma cells (TSC), which are a unique system on the basis that cancer stem cells can be compared with more differentiated cancer tumor cells in the same cell line under two different conditions. Preliminary data from the host group clearly demonstrates that mitochondrial differentiation accompanies cell differentiation. The consequences for cell meta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Dissecting the role of sperm transcriptome dynamics in intergenerational inheritance through native RNA nanopore sequencing'.

assistant: **Concept**

Mammalian sperm RNA is increasingly recognized as an additional source of paternal hereditary information beyond DNA. Environmental inputs, such as diet and stress, can reshape the sperm RNA signature and induce offspring phenotypes that relate to paternal environmental stressors. However, how, when and to what extent sperm RNA populations change, and what is the role that RNA modifications and other post-transcriptional regulatory layers play in shaping sperm RNA dynamics, remains poorly understood.  Here, we propose to characterize the dynamics of RNA populations during sperm formation and maturation using native RNA nanopore sequencing. This technology is suited to provide an integrative and comprehensive view of the transcriptome, epitranscriptome, degradation patterns and tailing dynamics simultaneously, and with single molecule resolution. We will establish novel library preparation methods that can capture the full sperm (epi)transcriptome, and will capitalize on our recently developed algorithms to map and quantify RNA modifications in individual RNA molecules. We will then apply these methods to reveal how paternal dietary exposures affect sperm RNA populations and the metabolic phenotypes of their offspring, and test whether the novel identified RNA candidates can transmit diet-induced paternal phenotypes to the subsequent generation. Finally, we propose to expand our previous work on direct RNA multiplexing to establish single cell direct RNA nanopore sequencing, to characterize the diversity and heterogeneity of the sperm RNA (epi)transcriptome at an unprecedented single cell and single molecule resolution.


**Keywords:** RNA modifications,  sperm RNA,  intergenerational inheritance ,  nanopore sequencing,  single-cell epitranscriptomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pensions Systems, Redistribution and Reform Policies in European Countries' in the context of a Sixth Framework call.

assistant: **Objectives**

All developed countries have a Pay-as-you-Go Social Security (PAYG) system. The systems are financed through a payroll tax levied on current workers' labour income, and provide a pension benefit to retirees. In European countries, like in all developed countries, the size of these systems has increased over the last few decades. The ageing of populations represents a common challenge. All countries are introducing reforms to deal with the ageing process. There are many different features in the existing social security systems, which are important to understand both their current design and the impact of planned reform. One of these concerns their intragenerational redistributive component. Apart from the typical redistribution across generations, i.e. from young to old, the PAYG social security systems may involve redistribution within the same generation across different income levels, i.e. from rich to poor. Some systems appear to redistribute more across income groups than others.This project aims at providing a comprehensive analysis of the intragenerational redistributive component of European social security systems, which includes an empirical analysis and a theoretical contribution, at a positive and normative level. The first objective is to provide an empirical analysis to assess the characteristics of the social security systems in European countries, in particular the degree of intragenerational redistribution in each country. I plan to use the European Commission Household Panel Data. The second objective is to provide a positive theory of the redistributive design of the social security systems. I plan to develop a bidimensional political economy model to explain contemporaneously the level of pensions and the intragenerational redistributive component, t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Oil & gas middle-east exhibitions' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Dissemination of hydrocarbons technologies developed by E.U's SMEs in the Middle East region through the organisation of a E.U's stand in four specialised exhibitions. These exhibitions have been selected in accordance with the importance of the local oil industry. The objectives of these stands are to enable the selected SMEs to present their technologies to the relevant end users or markets actors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Strengthening the strategic research partnership between China and the EU'.

assistant: **Concept**

The overall objective of STARTER is to reinforce EU-China S&T cooperation in the frame of the EU-China S&T Cooperation Agreement by means of implementing a series of dedicated promotional activities that will attract more focus of relevant European and Chinese scientists on concrete cooperation priorities and thus greatly contribute to a substantial increase of more excellent EU-China projects in the future under the EU Framework Program. The Chinese NCP organization CECO is the coordinator of the project. With the help of a strong extended consortium, the proposal will implement the following detailed workplans: WP1 Project management, WP2 EU-China NCP networking, WP3 RCP networking within China, WP4 Web service and database, WP5 Demonstration ev ents, WP6 Multilateral/bilateral S&T workshops, WP7 Dissemination activities. STARTER will build two highly efficient networks, EU-China NCP network and Chinese regional network, to accelerate the quick information flow between the EU and China. This is critical for other WPs. STARTER will make a sound dissemination plan to help the fulfilment of the objectives and potential impact. These will be done by improving CECO online services consisting of a updated website and a sophisticated database and d istributing relevant promotional materials such as newsletters, leaflets and posters among thousands of Chinese and European scientists. STARTER will also organize a number of promotional events including S&T exhibitions and multilateral/bilateral w orkshops to highlight the existing cooperation and stimulate this cooperation towards a higher level. The project has a total duration of 24 months, with a requested EC funding of 340,000 euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Satellite communications network of excellence - Phase II' (SATNEX-II) under Sixth Framework.

assistant: **Objectives**

Today, Europe is a space power - the space industry, satellite operators and space organisations are major players in their respective fields, which are global in nature. Over the years, European RandD in satellite communications has encompassed a large number of activities spanning many programmes and organisations, however, such initiatives have been restricted in their strategic value, with only limited collaboration and coordination and further exasperated by a lack of the critical mass required to make an impact on the world stage.The Commission's recently published White Paper on Space states that if Europe is to remain a Space Power it will need a policy to develop and deploy applications and to support the research and development, technology and infrastructures. As a first approach to integrate European research in satellite communications, the SatNEx NoE was established with the broad aims of removing barriers, integrating research and spreading excellence. The follow-on Phase-II project, SatNEx-II, aims to build on the groundbreaking SatNEx programme and, in so doing, achieve the longer-term goals that have been set in motion. The primary goals of the SatNEx-II NoE are to achieve long-lasting integration of European research in satellite communications and to develop a common base of knowledge.SatNEx-II will establish an innovative satellite communication platform for use by all members of the Network as a means for integrating research, teaching and training. SatNEx-II will disseminate the knowledge and the expertise generated to the international research community through various media at its disposal. SatNEx-II personnel will benefit from opportunities to move between institutions within the Network, to exchange ideas, share best practice and make use of