RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Precise Computation of Thermal Phase Transition Parameters' in the context of a Horizon Europe call.

assistant: **Objectives**

Our understanding of field theories at finite temperature (FTQFT) has undergone significant progress in the last decade. It has been boosted in part by the necessity of correctly interpreting the data from current and future detectors of gravitational waves (GWs) produced during Phase Transitions (PT) in the early and hot Universe. By now it is well established that the correct description is provided by a 3-dimensional Euclidean effective field theory (EFT) involving only those degrees of freedom that do not acquire large effective masses in their interaction with the thermal bath; all others being removed from the theory in favor of Lagrangian terms of increasing number of fields and derivatives of light particles.However, there are strong reasons to push perturbative calculations within this context beyond the current level of accuracy, computing also Lagrangian terms with more than two derivatives, so far mostly ignored. Remarkably, this would also allow us to address the fundamental question, to the best of my knowledge not yet conceived before, of whether there exist degrees of freedom that have gone unnoticed so far. The most important of these are the so-called skyrmions, namely localized field configurations topologically distinct from the vacuum that can be only stable in the presence of four-derivative interactions, which could very well ensue from thermal effects.The main goal of this project is to improve the accuracy of the EFT description of FTQFT as well as to analyse the impact of higher-order corrections on PT and GW parameters and also, on a different note, on the potential existence of skyrmions inhabiting only at high temperatures. To overcome the numerous difficulties, I will combine innovative ideas inherited from a variety of fields, including sc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Efficiency and Effectiveness of Training for Teachers’ Pedagogical Digital Competence'.

assistant: **Objectives**

Many policy-level measures and programmes have been developed across the EU to support the integration of digital tools into teaching and support the students learning through a variety of interventions, mainly through investments in infrastructure, improved access to digital learning resources and providing teacher training on how to implement digital infrastructure in teaching and learning. Less attention has been paid to the impact of investments in teacher preparation and training on student learning and growing inequities have not been addressed. By conducting 12 quasi-experimental intervention studies across 5 EU countries, the EffecTive project tests effects of training conditions on teacher pedagogical digital competence, classroom practices and student learning outcomes and self-regulated learning skills to boost disadvantaged students. The project will contribute to the European knowledge base on the effectiveness and efficiency of teacher training programs, a methodology and toolkit for synthesizing costs and benefits across studies and a cost-efficiency analysis to assess and identify cost-effective policy measures for training. With active involvement of policy makers and teacher training institutions, the project will have wider implications for improving teacher training for the integration of digital technologies in schools, providing equal opportunities for all learners and leading Europe to a more


**Keywords:** Professional Digital Competence, Teacher training, Self-regulated learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New approach to treatment of the blinding disease Retinopathy of Prematurity (ROP)' (ROP), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective is to develop a novel preventative intervention for the blinding disease retinopathy of prematurity (ROP) and other complications of prematurity.  The PREVENTROP consortium proposes to conduct preclinical studies (pharmacological, pharmacodynamics, pharmacokinetics and toxicological) in models and/or clinical studies (including phase III clinical trial) of an EU designated orphan medicinal product.  This orphan medicinal product has been granted the EU orphan designation.We have completed both a Phase I study and the first section of the Phase II study administering the growth factor complex IGF-I/IGFBP-3 (Premiplex®) successfully to preterm infants in order to prevent ROP– a discovery that we have taken from bench to bedside.Due to improved neonatal care, the survival of preterm babies has increased dramatically during the last decades. The downside of this improvement in survival rates is higher morbidity affecting these vulnerable infants. It should be emphasised that in a preterm infant any lasting morbidity will have a negative impact on the quality of life for a whole life span for both the individual and their families.One of the most severe morbidities affecting these infants is retinopathy causing severe visual impairment and blindness.Our research findings have rendered several editorials pointing at the hope of prevention strategies which if successful will change the paradigm for ROP and other morbidities in preterm infants.There are three major impacts of the present proposal; (1) clinical availability of a new orphan designated drug product, Premiplex®, and (2) improved care of preterm infants and (3) a significant contribution towards the goal of the International Rare Disease Research Consortium (IRDiRC) by delivering one new therap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Cold Molecules in Cavities' (CoMiC), addressing dissemination and exploitation.

assistant: **Impact**

Here we propose a radically new way to control chemical reactions on the quantum level. The Experienced Researcher (ER)will combine his long-standing expertise on cavity quantum electrodynamics (CQED) with the field of ultracold chemicalreactions, in which the host is one of the leading pioneers. We want to drive a photo-chemical reaction (photoassociation)within an optical cavity and in this way gain control over the reaction (objective 1). For this, we use the control overspontaneous photon emission by an optical cavity, as has been done with single atoms. This paves the way towards novelfascinating effects like superradiant chemistry, where a chemical process is enhanced due to quantum statistics.Furthermore, the optical cavity will be used as an ultrasensitive molecule detector of a new quality by detecting them withoutdisturbing their quantum state (objective 2). This novel interdisciplinary combination of physics and chemistry will open up anew research field, where the ER will demonstrate scientific innovation and independence.


**Keywords:** cold chemistry, cavity quantum electrodynamics, ultracold atoms
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The involvement of stakeholders to develop and implement tools for sustainable households in the city of tomorrow (TOOLSUST)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project will build upon the empirical results and the theoretical innovations made in the sustainable cities network process, and in the consumer oriented projects of the Environment and Climate Programme. The possibility for changes in lifestyles are, however, the main objective of our project. . We will expand the analysis beyond individual attitudes and the behaviour of household by including stakeholders such as: consumer organisations, environmental organisations, retailers, the local political authorities and local governments. In a multidisciplinary approach - including both natural and social science, the main innovative aspect of our project is the development of tools for a sustainable development of consumption and the involvement of stakeholders in this process: identifying goals, develop and test various tools for sustainable consumption and the implementation of these tools in everyday life.Three years synoptic time series were successfully obtained for all major inflows of warm, salty waters from the Atlantic to the Arctic and cold, dense outflows from the Arctic into the Atlantic. Their low frequency variability could be analysed in terms of signals propagating within the northern loop of the Atlantic thermohaline overturning circulation. Details of the model-based analysis of the flux variability has shown, that with the present knowledge there is no possibility to monitor longer term changes with a reduced measurement effort compared to the one installed during the project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Automatic Cancer Screening Based on Real-time PCR', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cancer accounts for nearly one-quarter of deaths in the developed world, exceeded only by heart diseases.  One of the key strategies in cancer prevention is early diagnosis through cancer screening programs.  Estimates of the premature deaths that could have been avoided through cancer screening vary from 3% to 35%, depending on a variety of assumptions. Beyond the potential to reduce mortality, screening may reduce cancer morbidity since treatment for earlier-stage cancers is often less aggressive than that for more advanced-stage cancers.  Currently many of these screening programs, have issues with false negative results, long time delays to obtaining the results, which increase patient anxiety and delays in starting treatments. In this project we will develop a novel rapid real time PCR/probe technology, in a microarray biochip format with the corresponding automated instrumentation for use as a rapid “point of care” diagnostic device.  Cervical cancer and its associated virus, human papilloma virus is the model system which will be used to develop this novel automated cancer screening technology. The novel real time PCR technology will permit detection of panels of multiple biomarkers in a single PCR reaction.   The partners have already developed prototype technology which partly demonstrates a microarray approach to real time PCR. The project will build on this, providing the innovation needed to transform a promising technology to an integrated system suitable for practical use at point-of-care setting.   The consortium includes four research institutes and two SMEs, who have extensive experience with real time PCR and microarray technologies, and are motivated to commercialise results. In addition partners 7 will act as end user, validating the system in a clin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NPX-101 is a portable home device for the treatment of moderate to severe depression, boasting more effective and safer outcomes, based on information deposited and received from the Cloud.' (NPX-101), addressing dissemination and exploitation.

assistant: **Impact**

Over 450 million individuals face depression, with over 800,000 suicide deaths per year, delivering a death rate of one person every 40 seconds. These figures are set to increase as estimates put 1 out of 4 individuals in the future to face similar mental disorders at some stage of life.NPX-101 is the first product line for treating moderate to severe depression, especially the 30% of patients who are currently drug-resistant. It is a patented non-invasive bioelectronic device that delivers Transcranial Magnetic Stimulation (TMS) in the form of a wearable Magnetic Resonance Imaging (MRI) helmet with shield protection. It delivers more precise and deeper energy stimulation, for fuller more effective therapy, removing the side-effects and other treament discomforts with current day treatment. Phase 1 of the SME instrument fits into the overall company plan of NeuroPrex and Omsbar to reach the market by contributing the financial resources needed to plan a fast sound wider deployment of the NPX-101. It would importantly help to deduce the quickest routes of distribution and market uptake for its entry-point of the U.K.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'More than color: Applying nanotechnologies for the multifunctional ceramic pigments development' (NANOPIGMY) targeting Seventh Framework.

assistant: **Abstract**

The change in automobile and construction materials requirements has led industries to themodification of bulk materials with nanoparticulate additives or to the application of later highperformance coatings in their materials to obtain better, cleaner, cheaper, faster and smarterproducts [1]. However, there still exist some barriers to nanotechnology-based productscommercialization and use [2]:- Manufacturing processes make the processes more complex- High processing costs for nano-materials- Need of qualified manpowerModification of low-cost pigments could help to introduce nanomaterials (polymers, paints andconcrete) in the market as manufacturing processes in automotive and construction sector wouldnot be altered so there would be no need of qualified manpower. The high-performance pigment(HPP) market performed well in 2006 and continued to grow for a number of reasons but manyof the raw materials used to manufacture HPPs increased in cost, thereby affecting the sellingprice of the finished goods to some extent. The price of high-performance pigments issignificantly higher than classic pigments, and as a result, there are fewer producers of specialtypigments and higher margins for the products.The use of modified low-cost pigment will help toreduce the price of HPPs and consequently the price of nano-materials.NANOPIGMY project seeks to produce cost-efficient multi-functional ceramic pigments withmore functionalities than color to give to the automobile and construction materials(plastic, paint and concrete) the required functionalities through the use of thesenanotechnology-based pigments, avoiding thus changes in manufacturing processes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Repair mechanisms of topoisomerase II DNA lesions' (2021-2027) targeting Horizon Europe.

assistant: **Abstract**

Topoisomerase II (TOP2) chemotherapeutics such as etoposide have been widely used in the clinic to treat leukemias, lymphomas, lung, testicular, and ovarian cancers. Etoposide was first approved for clinical usage in 1983. By intercalating into DNA, etoposide stalls the TOP2 catalytic cycle, generating toxic DNA lesions known as TOP2-DNA-protein crosslinks (TOP2-DPCs). After 40 years of intense research, the mechanisms employed by cells that counteract these lesions are starting to emerge. These include enzymes that reverse the crosslink, degrade the protein adduct, or remove the lesion by DNA incisions. Moreover, the protein ZATT was recently described as an essential regulatory enzyme that SUMOylates TOP2 and thereby stimulates TOP2-DPC resolution. Important and long-standing questions in the field relate to our understanding of how the different modes of repair are activated, coordinated between one another, and preferentially used by cells. Based on genetic data, ZATT appears to be the primary responder to TOP2-DPCs but how ZATT coordinates the different modes of repair via TOP2-SUMOylation is currently unclear. To address these questions and study TOP2-DPC repair, we propose to use a novel approach based on Xenopus egg extracts, which can recapitulate DNA repair mechanisms in a soluble environment. As part of our preliminary data, we show that these extracts can recapitulate TOP2-DPC repair via ZATT SUMOylation, providing a unique opportunity to delineate the molecular mechanisms underlying this reaction. By combining this system with complementary and innovative approaches, we seek to obtain a clear molecular understanding of the different mechanisms counteracting TOP2 lesions and unravel the molecular triggers that activate the different routes of repair. By doin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Visualisation of the early steps of human hepatitis B virus infection: a colourful approach' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The human Hepatitis B Virus (HBV) is a major human pathogen. Despite the energetic introduction of a vaccine against HBV in the developed world, still worldwide one in twenty people is chronically infected. People living in poverty, particularly in developing countries, are particularly at risk due to lack of access to vaccines and donor organs. Carriers of the human hepatitis B virus are at high risk of developing liver cirrhosis and hepatocellular carcinoma, and worldwide more than one million people die each year of these diseases. Due to the lack of a small animal model for HBV, and the extreme difficulty until now of in vitro culture of HBV, very little is known about the early stages of HBV entry into human hepatocytes. This proposed programme aims to fill this gap in knowledge through visualisation for the first time of HBV binding and uptake. This will be achieved through the use of a newly-developed cell line, HepaRG, which is permissive to HBV infection, in combination with cutting edge cell biological techniques in the immunofluorescence and confocal microscopy fields. New approaches will include the use of coloured" viral particles - those containing EGFP or DsRed2 for the visualisation of HBV entry as well as interference assays using HBV peptides anchored in the host cell membrane. In this way, not only will valuable information on HBV entry be gained, but also an in vitro system for the analysis of agents interfering with infection will have been established."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Single-Molecule Fluorescence Pulsed Interleaved Excitation, a novel tool to study biomolecular interactions' (SMF-PIE).

assistant: **Concept**

During the last few years, single-molecule fluorescence (SMF) methodologies have revolutionized the accessible information on biomolecular complexes, molecular dynamics, and biological mechanisms. Novel and important structural and dynamic insights can be obtained by studying molecules one by one, particularly into biological processes. In this field, the development of new methodologies and tools, on one hand, and of new improved fluorophores, on the other, are two major lines of research. In the current proposal, a cutting edge SMF methodology will be implemented: SMF Pulsed Interleaved Excitation (PIE) with two-colour coincidence detection, a technique that allows alternating excitation of fluorophores of different colours acting as donor and acceptor in fluorescence resonance energy transfer (FRET) processes. SMF-PIE has several advantages over the conventional SMF schemes to study biological systems, such as accurate determination of FRET efficiencies and inter-fluorophore distances, effective removal of the spectral, or distinction between molecules that have a low FRET efficiency from those that lack acceptor tag. The instrument performance will be calibrated and validated using model samples. Subsequently, SMF-PIE will be applied in three multidisciplinary biophysical approaches: 1) testing the feasibility and performance of newly synthesised fluorescein derivatives for SMF studies; 2) the resonance energy transfer between the new dyes acting as FRET donors and a DNA intercalator fluorophore as acceptor will provide insights into the mechanisms of intercalation of these carcinogenic molecules; 3) SMF-PIE will be employed to study the early pre-fibrillar aggregates from an amyloidogenic protein, the SH3 domain of α-spectrin, providing insights into the amyloid fi