RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Trento EuroSchools in Algebraic Geometry 2001-02'.

assistant: **Objectives**

PROPOSED EVENTS. Euro Summer Schools TRENTO2001-02PROPOSER. EAGER, a European Network in Algebraic Geometry, sponsored by the EC Human Potential Programme (contract HPRN-CT-2000-00099). KEYNOTE SPEAKERS (all confirmed). L. Caporaso (IT), J. Harris (USA),I. Morrison (USA) in 2001, H. Clemens (USA) and C. Voisin (FR) in 2002 PROJECT TOPIC. Algebraic geometry is a core mathematical discipline that has been intensively studied since the late 19th century. It provides a range of geometric techniques describing solutions to equations. Because most of mathematics is concerned at some level with setting up and solving equations, for example to model problems in applications, algebraic geometry plays a central role in mathematics and physics. The planned schools address particularly themes with close connections to physics (string theory) and arithmetic: the invited keynote speakers will lecture on Moduli Spaces of Curves in 2001, and on Algebraic Cycles and Hodge Theory in 2002.PROGRAMME CONTENT: The TRENTO schools are designed for effective, advanced training of post-docs in algebraic geometry and related fields. Each event brings 40 European post-docs and 20 further participants together with a few selected international experts as keynote speakers. In the mornings, the invited experts give mini-courses on the chosen topics, with lectures and problem sessions. Selected junior participants give seminar lectures in the late afternoons. Each junior talk is followed by a discussion with particular emphasis on constructive comments by the keynote speakers. The early afternoons and the evenings are reserved for junior-to-junior, junior-to-senior, and senior-to-senior discussions, with office hours" scheduled by the invited speakers."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A multiplexed biomimetic imaging platform for assessing single cell plasticity (Plastomics) and scoring of tumour malignancy' (Plastomics) targeting Horizon Europe.

assistant: **Abstract**

Metastasis is the major cause of death in cancer patients due to cancer cell dissemination to distant organs. Cell plasticity is a core characteristic of metastatic cells and confers cellular adaptation capabilities to variable mechano-chemical tissue microenvironments. However, to date, specific quantitative measures of cancer cell plasticity associated with tumour aggressiveness and therapy resistance have remained difficult to establish. A major limitation is the availability of highthroughput multiplexed assays that can capture phenotypic heterogeneity and morphodynamic plasticity at the single cell level in standardized 3D culture conditions reflecting in vivo tissue microenvironments. The PLAST_CELL interdisciplinary consortium will pioneer the development of a microfluidics-based imaging platform to categorize and score cancer cell plasticity within diverse physiologically relevant 3D biomimetic culture conditions. The platform will enable to perform single cell multi-scale morphometric and molecular live cell data collection (PLAST_DATA) with minimal sample size (<10k cells). Data will be generated based on single molecule-sensitivity marker detection and cellular/subcellular morphodynamic feature recognition via minimal-invasive long-term super-resolution microscopy and parallel morphodynamic imaging of cellular behaviour. Computational integration of PLAST_DATA using preclinical models and patient samples will enable to develop a quantitative classification of tumour cell plasticity and predictive scoring of cancer aggressiveness, metastasis and drug resistance (PLAST_SCORE). The ability to assess cell plasticity based on cellular behaviours is beyond current clinical parameters and will strongly impact diagnosis, prognosis and treatments. The PLAST_CELL platf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Biodiversity of endosymbiotic microbial communities and their role in food webs involving tropical arboreal ants.'.

assistant: **Concept**

Nutritional mutualisms between tropical arboreal ants and their gut bacteria are an essential part of the web of interactions that underpin the keystone role of ants as predators of arthropods in tropical forest canopies. These ecologically-important symbioses are unstudied, apart from a few highly specialised examples. Furthermore, ant-bacterial-plant symbioses are convenient model systems to investigate insect-bacterial symbioses because the diets of tropical plant-associated ants are often highly variable among closely related species and even among colonies in a single species. They offer greater scope for studying questions about functional diversity than do other insect-bacterial symbioses, such as those between Buchnera and aphids -a strictly phloem-feeding insect group that have provided the foundation from which exploration of diversity can now begin.   Study of ant-bacterial-plant symbioses may elucidate new roles for bacteria and new mechanisms for their effects. The immediate goal is to establish the core patterns of bacterial diversity in ant guts at different levels, from intra-population variation in the African plant-ant Aphomomyrmex (mediated by yet another partner in the interaction, hemipterans), to inter-population and interspecific variation in Aphomomyrmex and its sister taxon Petalomyrmex, and finally to a comparison of bacterial symbionts of the pantropical lineage to which these ants belong. Patterns in diversity at multiple levels will provide clues about the functioning and the evolutionary history of ant-bacterial symbioses. The long-term goal is to characterise functional diversity of ant-gut bacteria. Although closely related bacterial species can have different ecological niches, phylogenetic affiliation of the bacteria identified as symbi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Suspicious and Abnormal Behaviour Monitoring  Using a Network of Cameras & Sensors for Situation Awareness Enhancement' (SAMURAI).

assistant: **Innovation**

The aim of SAMURAI is to develop and integrate an innovative intelligent surveillance system for robust monitoring of both inside and surrounding areas of a critical public infrastructure site. SAMURAI has three significant novelties that make it distinctive from other recent and ongoing relevant activities both in the EU and elsewhere: *SAMURAI is to employ networked heterogeneous sensors rather than CCTV cameras alone so that multiple complementary sources of information can be fused to create a visualisation of a more complete ‘big picture’ of a crowded public space. *Existing systems focus on analysing recorded video using pre-defined hard rules, suffering from unacceptable false alarms. SAMURAI is to develop a real-time adaptive behaviour profiling and abnormality detection system for alarm event alert and prediction with much reduced false alarm.   *In addition to fix-positioned CCTV cameras, the SAMURAI system will also take command input from control room operators and mobile sensory input for patrolling security staff for a hybrid context-aware based abnormal behaviour recognition. This is in contrary to current video behaviour recognition system that relies purely on information extracted from the video data, often too ambiguous to be effective. SAMURAI has the following scientific objectives: 1. Develop innovative tools and systems for people, vehicle and luggage detection, tracking, type categorisation across a network of cameras under real world conditions. 2. Develop an abnormal behaviour detection system based on a heterogeneous sensor network consisting of both fix-positioned CCTV cameras and mobile wearable cameras with audio and positioning sensors. These networked heterogeneous sensors will function cooperatively to provide enhanced situation awarenes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Acrylic acid plasma polymer coatings for adhesion promotion of aluminium/epoxy joints'.

assistant: **Concept**

This research program aims to develop a process to replace the current technology of chromating used as a pre-treatment to promote adhesion to aluminium. Plasma polymer coatings offer the opportunity of replacing the environmentally hazardous chromating process with clean plasma deposition. Radio frequency plasma deposition of plasma polymerised acrylic acid (ppAAc) coatings will be used to impart a stable acid chemistry to aluminium, to facilitate strong and durable covalent bond formation with adhesives. To develop an understanding of the chemistry and morphology of the coatings and how these relate to the deposition parameters we will carry out chemical surface analysis (XPS, SIMS and ATR-FT IR) and atomic force microscopy upon the coatings. The stability of the coatings will be probed through solvent washing. The effect of ppAAc coatings upon the adhesion of joints formed with epoxy based adhesives will be tested using the lap-shear test and surface analysis fractography.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '6th International Conference on Near Field Optics and Related Techniques' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

NFO-6 is the 6th international conference on Near Field Optics (NFO) and Related Techniques, which will be organised at the University of Twente in the Netherlands in August 2000. The Twente campus university has extensive professional experience in organising international conferences. The campus site has a hotel and a variety in guest and student houses to guarantee housing of both senior and young researchers. About 350 participants from mainly Europe, US and Japan are expected at NFO-6 Twente 2000. With NFO-6 the international conference for sub-wavelength optics finally returns to Europe, after sucessful and steadily expanding meetings in Besançon 1992, Raleigh 1993, Brno 1995, Jerusalem 1997 and Shirahama 1998.The NFO conference series is the principal forum for advances in sub-wavelength optics, near field optical microscopy, local optical field enhancement, instrumental developments and the wide range of applications. Since the early nineties the NFO field is going through strong and fast scientific and technological developments. Especially near-field scanning optical microscopy (NSOM), which provides the ability to resolve sub-wavelength structures beyond the diffraction barrier, has found its way in a wide variety of applications in physics, chemistry, materials science, data storage and life sciences. The goal of the conference is to create an environment for open exchange of topical research information and to stimulate discussion on novel concepts and fields of application. The conference will especially provide an excellent opportunity for European scientists to exchange their latest results and ideas with the world top on NFO. Obviously the community interest prevails throughout this project.ftp://ftp.cordis.lu/pub/improving/docs/HPCF-1999-00141-2.pdf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Muscular Faith: The Interplay between Sport and Religion in Africa' (MFA).

assistant: **Innovation**

Many young African lives are paused in ‘waithood’ (Honwana 2012): no longer children but unable to become independent adults. Many manage this situation through sport, religion, or both. The question at the heart of MFA is how sport and religion in tandem provide a way out of ‘waithood’.Sport and religion alternately reference each other as performance enhancers. Both have been posited as catalysts for development and integration, however, their interplay remains under-theorised. Social science views sport through a secular lens, while religious studies have been slow to recognise the ‘religious’ elements of sport. If they do, studies are limited to a Western, Christian context. MFA will span existing academic siloes by taking a multidisciplinary approach, considering the interplay between sport and religion from a non-Western, non-Christian perspective.Africa is known as the ‘sporting continent’ and Africans as the ‘most religious people’, making it a unique setting to investigate i) the ‘sport-religion nexus’ – how each appropriates the other’s values and practices and how they affect each other; and ii) how this nexus enables meaning and purpose. MFA will 1) deepen understanding of the sport-religion nexus; 2) innovate an Afrocentric, actor-oriented approach focused on lived experience; 3) centre Africa’s global sporting prowess, redressing misconceptions of Africa as peripheral; and 4) assess the potential of the sport-religion nexus as a catalyst for youth development. This will be achieved through case studies that document sports appropriating elements from different religions (Christianity, Islam, and African Endogenous Religions): boxing in Nigeria; soccer in South Africa; karate in Egypt; long-distance running in Kenya.MFA’s dissemination and open-access acade
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'THE OPTICAL NOSE: An On-line, Non-invasive and Total-profiling Instrument for Trace Gas Sensing Applications in Medical Sciences' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of this project is to develop a non-invasive diagnostic tool for medical applications, such as the early diagnosis of diseases, by real-time analysis of trace gas concentrations in human breath. Presently, early detection requires very expensive invasive tests, e.g. biopsy, endoscopy and x-rays that may be painful and potentially harmful. The challenge to modern medicine is to develop cost-effective and non-invasive tests for early diagnosis. We propose to develop and apply a novel type of laser-based analytical instrument, the optical nose, for rapid screening of human breath, in order to identify in real time the specific markers related to various diseases. We shall focus on chronic obstructive pulmonary diseases, lung cancer and colorectal cancer, as lead to get a proof of concept". The consortium will perform research on the currently most promising trace gas analysis methods based on advanced mid-IR laser sources, optical parametric oscillators (OPOs), in combination with ultra-sensitive spectroscopic detection methods. By exploiting the latest solid-state laser and optical fibre technology, the capabilities of existing OPOs will be considerably extended and matching detection methods will be developed to retrieve and computer-analyse trace gas concentration data within only seconds. The laser-based analytical instrument will operate in the 2.5-10 mm wavelength range with maximum coverage of the molecular fingerprint region and a superior wavelength agility (tens of thousands of distinct wavelengths per second). This enables rapid and accurate medical examination of human breath, as required for building a database connecting the spectroscopic data of the breath analysis with medical evidence."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Structural mechanism of recognition, signaling and resection of DNA double-strand breaks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

DNA double-strand breaks are perhaps the most harmful DNA damages and result in carcinogenic chromosome aberrations. Cells protect their genome by activating a complex signaling and repair network, collectively denoted DNA damage response (DDR). A key initial step of the DDR is the activation of the 360 kDa checkpoint kinase ATM (ataxia telangiectasia mutated) by the multifunctional DSB repair factor Mre11-Rad50-Nbs1 (MRN). MRN senses and tethers DSBs, processes DSBs for further resection, and recruits and activates ATM to trigger the DDR. A mechanistic basis for the activities of the core DDR sensor MRN has not been established, despite intense research over the past decade. Our recent breakthroughs on structures of core Mre11-Rad50 and Mre11-Nbs1 complexes enable us now address three central questions to finally clarify the mechanism of MRN in the DDR:- How does MRN interact with DNA or DNA ends in an ATP dependent manner?- How do MRN and associated factors such as CtIP process blocked DNA ends?- How do MRN and DNA activate ATM?We will employ an innovative structural biology hybrid methods approach by combining X-ray crystallography, electron microscopy and small angle scattering with crosslink mass spectrometry and combine the structure-oriented techniques with validating in vitro and in vivo functional studies. The anticipated outcome will clarify the structural mechanism of one of the most important but enigmatic molecular machineries in maintaining genome stability and also help understand the molecular defects associated with several prominent cancer predisposition and neurodegenerative disorders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Photodiode integration on silicon nitride' (POTION).

assistant: **Concept**

In this project the fellow, Gabriele Navickaite, will conceive and realize monolithic integration of semiconductor photodetectors on top of a passive Silicon Nitride (SiN) Photonic Integrated Circuit (PIC). This project will show for the first time the monolithic combination of the SiN passive platform with an active semiconductive element and thus constitutes an important step towards further integration. It clearly fills a market gap in the growing integrated photonics business.Whereas the SiN platform has obtained significant attention in the past years, because of its low loss (10 times better than silicon) and large transparency window, the application space is limited by the absence of active elements on the PIC platform. A research and business breakthrough would be the combination of the low loss SiN platform with an active material for photon detection. LIGENTEC has already gained market insights that the additional integrated functionality is desired by the end-customer and will be still affordable due to wafer scale processing. In addition to passive SiN component (see an array waveguide grating chip in Figure 1) LIGENTEC has developed fabrication processes that enable evanescent coupling of SiN to other materials.The applicant seeks to build on this development and integrate evanescently coupled photodetectors. The fellow Gabriele Navickaite together with the host company LIGENTEC proposes to reach the following objectives in the time frame of 24 months for the first time:●Demonstration of integrated photodiodes on SiN photonic platform●Demonstration of a packaged SiN PIC for wavelength splitting at VIS wavelengths and detecting (DEMO) This 24-month project foresees to design and simulate the integrated photodiode, develop the material and finally fabricate