RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'SCale Up an integrated care package for diaBetes and hYpertension for vulnerable people in Cambodia, Slovenia and Belgium', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Background. Diabetes and hypertension are increasingly dominant in the global burden of disease. Effective interventions for prevention, detection, treatment and control of both conditions are available, but do not reach all people in need. Countries are struggling how to scale-up interventions sustainably and effectively. There is an urgent need to develop and document strategies on how to do so. Method. This project examines the scale-up of existing evidence-based packages for control of diabetes and/or hypertension with five components: (a) identification of people with HT and/or T2D and (b) treatment in primary care services, (c) health education and (d) self-management support to patients and caregivers, and (e) collaboration among caregivers. The project develops, implements and evaluates roadmaps for the national scale-up of this package, in three different types of countries: a low-middle income country with a developing health system (Cambodia), a former socialist country with a centralised health system (Slovenia), and a Western European country with a decentralised system (Belgium).The research objectives are: 1) to analyse the organisational capacity to scale-up the integrated care package and to assess contextual barriers and facilitators; 2) to develop and implement roadmaps for a national scale-up strategy in each country; 3) to evaluate the impact of scale-up on health outcomes and costs; and 4) to generate lessons for other countries. Outcomes. The project will result in comprehensive scale-up strategies and increased diabetes and hypertension control in each country. The involvement of policy-makers, professionals and patients will ensure the local relevance and impact. The project is innovative in applying the conceptual insights from scale-up science
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Improving Kidney Health by Targeting  Urinary Biomarkers for Tubular Function' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Chronic kidney disease (CKD) affects one in ten people worldwide and is often progressive. Progressive CKD not only causes kidney failure, but also premature aging, cardiovascular disease, and loss of quality of life. Currently, progressive CKD can only be diagnosed after irreversible damage to the kidney has already occurred. There is therefore an urgent need for earlier biomarkers. The kidney consists of filters and tubules, but diagnosis of progressive CKD is currently based on filter function alone. This is surprising, as it is tubular injury that drives CKD progression, and it is the tubule that is targeted by recently developed kidney-protective treatments. U-Tube therefore aims to identify and apply next-generation biomarkers for kidney tubular function to facilitate the early detection and treatment of progressive CKD. My central hypothesis is that the factors that cause tubular injury and CKD progression, are present in urine and therefore detectable as biomarkers. I will focus on urinary microcrystals and extracellular vesicles (EVs) as the drivers of tubular injury, which I will first study in tubuloids using a multi-omics approach. Subsequently, I will perform a large-scale analysis of crystallization and EVs in urine samples from people with stable or progressive CKD. I will then single out those biomarkers that can be targeted by kidney-protective treatment. These targetable biomarkers will be moved forward for the development of a high-throughput tubular panel that I will test for its potential to predict progressive CKD, compared to a gold standard test for tubular function. U-Tube will use cutting-edge innovations to identify urinary biomarkers for tubular function that are targetable and implementable in clinical practice. If successful, it will advanc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Novel surface coating for biomedical devices' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

- To develop a new coating based on Titanium-Nitrid-Oxid as a low-adhesive surface material for reduced formation of bacterial-biofilm on biomaterials.- To develop a new coating (TiNxOy) as low-thrombogenic surface material for the reduction of the clotting process on biomaterials.- To test the anitthrombogenic potential of TiNxOy as a surface coating for prosthetic heart valves and to provide new data for the design of a novel artificial heart valve (no need for anticoagulation).A novel surface coating has recently been developed which consists of a titanium-nitrid-oxid compound (TiNOx) and which is deposited by a physical vapour deposition process on biomaterials. This compound has a low surface adherence and electrophysical characteristics, which can be varied in a wide range between metallic and ceramic properties with a potential for a marked reduction in fibrinogen activation at the surface/blood interface. In a screening and evaluation phase the physico-chemical behaviour of different TiNOx coatings will be determined in respect of biofluid-adhesion, biofilm and thrombus formation. Various TiNOx films will be tested using static and dynamic methods i.e. contact angle measurements, continuos growth systems, shearforce and chemostat measurements for selected bacterial strains and a special designed flow chamber for investigation of fibrinogen and platelet activation. The influence of TiNOx-coating on the rheology of the mechanic heart valves will be investigated with Laser and MR - flow-models. On the basis of the results of these experiments the optimal TiNOx-coating will be selected for further in vivo testing. The performance of coated versus uncoated cardiac valves will be evaluated in the chronic pig-model with a follow-up for 3 to 6 months. A new monoclonal I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'An innovative non-contact and harmless screening modality set to change the course of breast cancer detection and patient monitoring' (ThermoBreast).

assistant: **Concept**

Female breast cancer is the most diagnosed cancer worldwide. In 2020, the International Agency for Research on Cancer estimated more than 2.26 million new cases of breast cancer. Early detection is crucial to survival; recovery rates approach 90% when detected in early stages. National population-based cancer screening programmes in Europe currently implement 3 standard imaging modalities: mammography, ultrasound and MRI. The downsides of these screening methods include ionising radiation, high costs and high false positive rates in screening results.Our multidisciplinary consortium of 16 partners from 10 countries aims to contribute to EU’s Mission on Cancer and Beating Cancer Plan by drastically improving the prevention, diagnosis and monitoring of breast cancer while reducing the burden on women and female patients and their families, health care professionals and others who are directly or indirectly affected by breast cancer.ThermoBreast proposes a new solution for accurate, harmless and non-contact screening, equally applicable for all age groups and breast densities and capable of detecting pre-cancerous states. This risk-free screening technology, recently patented by the project coordinator ThermoMind LTD, can detect vascular anomalies and asymmetry, caused by cancerous growth. It combines innovative screening through multiple sensitive infrared sensors with advanced AI analysis of temporal dynamic thermal patterns. Through its patient-centred integrated diagnostics approach, this project converges intelligent computer vision, blood vessel extraction and tissue analysis with advanced information technology to deliver a medical class 1 device that will be validated in an international multicentre clinical study. To enhance stakeholder participation, ThermoBreast
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Decomposing Heterogeneity in Autism Spectrum Disorders' (AUTISMS) targeting Horizon 2020.

assistant: **Abstract**

Autism spectrum disorders (ASD) affect 1-2% of the population and are a major public health issue. Heterogeneity between affected ASD individuals is substantial both at clinical and etiological levels, thus warranting the idea that we should begin characterizing the ASD population as multiple kinds of ‘autisms’. Without an advanced understanding of how heterogeneity manifests in ASD, it is likely that we will not make pronounced progress towards translational research goals that can have real impact on patient’s lives. This research program is focused on decomposing heterogeneity in ASD at multiple levels of analysis. Using multiple ‘big data’ resources that are both ‘broad’ (large sample size) and ‘deep’ (multiple levels of analysis measured within each individual), I will examine how known variables such as sex, early language development, early social preferences, and early intervention treatment response may be important stratification variables that differentiate ASD subgroups at phenotypic, neural systems/circuits, and genomic levels of analysis. In addition to examining known stratification variables, this research program will engage in data-driven discovery via application of advanced unsupervised computational techniques that can highlight novel multivariate distinctions in the data that signal important ASD subgroups. These data-driven approaches may hold promise for discovering novel ASD subgroups at biological and phenotypic levels of analysis that may be valuable for prioritization in future work developing personalized assessment, monitoring, and treatment strategies for subsets of the ASD population. By enhancing the precision of our understanding about multiple subtypes of ASD this work will help accelerate progress towards the ideals of personalized me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Inferring the cross-platform structures of socio-political POLARization around CLIMATE change on social media' (POLARCLIMATE), addressing dissemination and exploitation.

assistant: **Impact**

Addressing climate change's existential threat demands a global effort to rapidly reduce carbon emissions. However, political gridlock fuelled by societal polarisation can stymie effective action. POLARCLIMATE confronts this challenge, studying interventions to curb climate scepticism and foster consensus.POLARCLIMATE will use a social media lens to advance the current state-of-the-art on climate polarisation, tackling three key research challenges. First, existing studies of climate polarisation fail to consider how passive engagement with climate narratives shape climate opinions. Second, studies of climate polarisation are typically siloed to a single platform, limiting their demographic relevance and preventing a robust cross-platform analysis of content and structure. Finally, studies do not adequately consider the agents who drive climate polarisation, especially those organisations with a vested financial interest in maintaining the status quo. To address these challenges, POLARCLIMATE will take an interdisciplinary, multi-modal approach drawing on quantitative methods from networks and data science, and qualitative methods from climate communications. The analysis of passive consumption and cross-platform structure will be studied using Bayesian inference and network reconstruction methods, and content will be analysed using taxonomies of climate scepticism and computer-aided topic modelling across various climate publics. Finally, organisational financial interests will be identified by using Bloomberg financial data, and compared to the rhetoric of corresponding organisations on social media.POLARCLIMATE will balance scientific rigour with policy relevance. The project's outputs will offer multi-modal evidence to inform the development of concrete policy recom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Next generation ketoamide inhibitors of fibroblast activation protein (FAP) to revolutionize radionuclide therapy in cancer.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Fibroblast activation protein (FAP) is a serine protease that is highly expressed on cancer-associated-fibroblasts (CAFs), in nearly all tumor types. Its limited presence in healthy tissues makes it an attractive diagnostic and therapeutic biomarker for cancer. UAMC1110, a potent and specific FAP inhibitor discovered by the host, opened the way for the development of the so-called FAPIs. These are tumor-targeting molecules composed of a UAMC1110 moiety and a radionuclide. The latter can either be a diagnostic radionuclide for PET imaging, or a more cytotoxic radionuclide for cancer therapy. Radiodiagnostic FAPIs are now entering clinical practice, but their therapeutic counterparts face challenges, related to the relatively short tumor residence time of currently available molecules. The latter leads to significant leaking of toxic radioactivity from the tumor. To overcome this issue, we will develop ketoFAPIs that form long-lived covalent bonds with FAP. This should already ensure significantly longer tumor residence. The ketoFAPIs will also be bound to the surface of gold nanoparticles (AuNPs). The resulting constructs could have further increased tumor residence through the multivalency effect. This interdisciplinary proposal covers 1) the chemical preparation of novel ketoFAPIs and derived AuNPs, 2) their in vitro characterization and 3) in vivo investigation in a mouse model of colorectal cancer. Overall, the project can lead to safer and more efficient FAPIs for radiotherapy applications. The status of FAP as a pan-cancer biomarker entails that these FAPIs could be applied in nearly all cancer types.


**Keywords:** FAP, ketoamide, cancer, AuNPs, theranostics, radionuclide therapy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'AI-based software for digital drug testing'.

assistant: **Objectives**

Drug consumption is rising worldwide. In Europe, alcohol and other narcotic drugs cause 30% of all road deaths, 25% of all fatal workplace accidents, and >54% of all e-scooter accidents. We believe that most of these accidents could be prevented using the right tools. To this aim, we have developed Eyescanner, a revolutionary AI-based software that detects the influence of alcohol and other drugs through image analysis of eye area. Eyescanner is a versatile digital tool that can use existing tech infrastructure: smart phones, integrated into cars, hospital equipment, etc. Our solution offers a drug test for environments where drug testing was not possible (cars, e-scooter apps) and a better alternative to currently used methods (law enforcement, corporate, healthcare).We now seek EIC support to finalize Eyescanner development and demonstrate its application on different scenarios. We will partner with industry leaders to transform Eyescanner into the digital drug testing global leader


**Keywords:** Digital drug testing,Eye tracking,Machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative propellants in hybrid propulsion technology and its applications in space transportation' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Nowadays, chemical propulsion is based on solid (launch applications like first stage booster) or liquid technologies (upper stage engines). Complementary, hybrid propulsion technology, as defined in ORPHEE (Operational Research Project on Hybrid Engine in Europe), appears as a new generation of advanced space transportation system. Engines based on this innovative propulsion concept provide advantages like thrust performance, throttling (thrust modulation), versatility (easy adaptation to various configurations), simplicity, safety. which significantly reduce the global engine cost. It will help to consolidate the long term sustainability and ensure a technology needed by the European propulsion space community to remain independent.  Hybrid propulsion principle is based on the injection of a liquid oxidizer into the engine combustion chamber where it reacts with a solid fuel to generate hot gases providing the thrust. Enlarge the burning surface is the current proposed solution to reach the needed performance level. It dramatically increases the solid grain volume and the engine weight, limiting the applications. The regression rate is a key parameter controlling the solid fuel grain design. Its increase is a very attractive solution to reduce the grain volume.   The main objectives of ORPHEE are to increase versatility of space propulsion system, ensure significant increase performance of hybrid engine, improve solid fuel technological maturity from TRL 1 to 3 and gather European skills on hybrid propulsion and ensure European access to space  In near future, the availability of new hybrid engines will allow the access to new space transportation missions and to obtain significant costs reduction. It will consolidate the knowledge on this innovative technology, allow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New bio-based and sustainable raw materials enabling circular value chains of high performance lightweight biocomposites' (R-LIGHTBIOCOM).

assistant: **Concept**

New lightweight High-Performance Composite (HPC) materials and efficient sustainable processing technologies will have an enormous environmental and performance benefit in all sectors of application. However, current sustainable HPC application is limited to large sectors due to their limitations in terms of long processing times, high prices and low recyclability. To overcome these limitations, r-LightBioCom propose a paradigm shift in the way HPC are manufactured and recycled, unlocking sustainable-by-design production of lightweight HPC. Therefore, the project will enable new circular value chains towards r-LightBioCom results, contributing to environmental-related EU goals and reducing the HPC waste generation and the use of non-sustainable fossil resources.To this end, a sustainable catalogue of new advanced biobased and recycled HPC materials will be initially developed with inherent recyclability properties (at least 3 new types of bio-resins, 4 new biomass-derived nanofillers and additives, and 3 families of sustainable fibre-based textile products). To reduce current associated manufacturing costs and high energy consumptions and emissions, efficient processing techniques will be developed (2 new fast curing techniques) combined with recycling technologies for the new catalogue of materials to reduce waste generation and induce circularity.  A new open method and related tools (Coupled Ecological Optimisation framework) will promote and standardise holistic sustainable HPC design, modelling and systematic optimisation, leading to continuous sustainable catalogue growth and inclusion of new families of biobased, recyclable lightweight HPC at competitive cost. All results will be validated in 3 use cases at automotive, infrastructure and aeronautic industries wit