RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Excitation-contraction coupling and calcium signalling in health and disease' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

In skeletal and heart muscle, the signal transduction between the cell surface membrane and the contractile apparatus, called excitation-contraction coupling (ECC), is a model for calcium flux and homeostasis of unique importance. No other organs respond so dramatically to their use or inactivity by hypertrophy or atrophy. Our aim is to study the regulation and molecular basis of ECC in health and disease in man and in animal and cell models.Our goals are:a) to identify novel ECC proteins and characterize their interaction at the molecular level;b) to study localization and targeting of the proteins to their respective compartments, and their interaction using cellular and animal and disease models;c ) to functionally analyze ECC and calcium signaling with high-resolution imaging and electrophysiological techniques;d) to study the genetics and pathophysiology of disease arising from EEC defects. Our proposal integrates a large number of state-of -the-art technologies in the fields of protein biochemistry, molecular genetics, cell biology and physiology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of novel magnetron electrodes to coat internal surfaces of engineering components' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Teer Coatings constructed, adapted and improved the novel magnetron system. Enterprise Ireland studied the basics of these depositions and deposited on tools. DaimlerChrysler deposited and improved automotive coatings for inner wall deposition. DWH and Wavin applied the coatings in field tests.Teer Coatings had built single cylindrical magnetrons 40 and 22mm in diameter and a four cylindrical magnetron system and carried out deposition of various materials, e.g Tantalum for further improvement of the cylindrical magnetron. These improvement had a large impact on layer quality and uniformity. Furthermore Teer Coatings deposited coating for increased demand on tool components at the enduser DWH and Wavin.As major result the novel magnetron system- in particular the arrangements of magnets at the deposition source- increases the utilisation of depositing material (impact on cost) and the quality of the coating. The uniformitiy of the coating has to be improved. Chromium based PVD- coatings show high adhesion on automotive Aluminium and Steel based components. In particular Cr-N-C based systems as deposited at Daimler Chrysler have low friction as figured out in model and field tests.Enterprise Ireland carried out a range of deposition experiments using the cylindrical magnetron system and evaluated parameters such as the influence of cylinder diameter, pressure, bias frequency and the addition of inert gasses on coating performance. In addition to coatings sent to end users within the consortium a number of components were coated for evaluation by Irish SME engineering and polymer device manufactures. These coatings are now routinely used by a number of these SME's in there manufacturing process.DWH achieved best resuLts (100% improvement) combing the elaborated PVD coatin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Lactococcus lactis as a delivery system of macrophage Migration Inhibitory Factor (MIF) to enhance mucosal transport of biologically active compounds' (MIF), addressing dissemination and exploitation.

assistant: **Impact**

In order to induce a robust and effective immune response at mucosal level, bacteria, viruses and other antigens must cross the intestinal barrier. Highly specialised antigen-sampling M cells are strategically located in certain areas of the gut and play a fundamental role in the induction of mucosal and systemic immune responses by transporting antigens to the mucosal-associated immune system (MALT). Large numbers of in vivo studies, in which the follicle-associated epithelium (FAE) of gut-associated lymphoid tissue (GALT) or, more recently, nasal-associated lymphoid tissue (NALT) was challenged with pathogens or microparticles clearly demonstrated that M cells within the FAE are the primary site for antigen-sampling. We have recently found that the cytokine Macrophage Migration Inhibitory factor (MIF) plays an important role in the formation of fully operational M cells in the FAE and here we commend the idea of investigating the potential of MIF as novel enhancer of M cell-mediated transport of antigens an d therapeutics to the mucosal immune system. The main objective of this proposal is to use the recombinant lactic acid bacterium L. lactis for the delivery of MIF to the mucosal (oral and nasal) immune system in order to increase the number of fully operat ional M cells of the FAE. In this way we will be able to design novel and more effective strategy for oral or nasal delivery of vaccines and other biologically active compounds. Generation of LAB expressing lymphokines has already been demonstrated and the advantage of using L. lactis is that it has GRAS status and is routinely used in food fermentation and as probiotic functional food ingredient.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cost-effective rotordynamics engineering solutions (CERES)' (CERES) targeting Fifth Framework.

assistant: **Abstract**

This project aims to achieve advances in the critical technology area of aircraft engine design, in particular in engine rotor dynamics. By improvements to engine dynamics models and their validation, the work will contribute to solutions of the rotor dynamics problems which are met throughout an engine project's life, from the design stage, where the need is to predict fan blade off loads accurately to produce safe yet lighter, more efficient engines, through the development stage, where more rapid resolution of problems will contribute to reduced time to market, and finally in production and maintenance where reduction of costs will be achieved. Importantly, the work will investigate the rotor dynamics of the post fan blade off windmill condition, where there remains a safety concern that the full range of possible engine rotor dynamic behaviour has not yet been defined. It is expected that the project will raise competitiveness of the European industry by achieving reduced weight of the engine and its installation, by up to 100 kg for an aircraft, by enabling reduced time to market for both the aircraft and its engines (engine design/development time reduced by up to 3 months, i.e. 8%) and the cost of rectifying build faults on engine pass-off testing will be reduced by up to 30%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Low cost apparatus and remedial products for small scale activated sludge plants', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Two firms Austep (IT) and Avecom (BE), propose to develop a low cost system composed out of a simple control apparatus coupled to a dosage of remedial products for small scale activated sludge treatment plants. A sensor developed by Austep monitors the ammonium in the influent and the effluent as a signal of a poorly performing treatment plant. A very critical process in the activated sludge can thus be followed up. Avecom on the other hand has a big supportive supplement to stimulate essential bacteria such as the nitrifiers and the floc formers in activated sludge. Other complementary combinations of apparatus and remedial products have to be investigated. Such a package can provide a robust solution at a reasonable cost, for smalls scale activated sludge plants which normally have few or no trained personnel and few or no apparatus for monitoring. It will help to avoid long periods of poor performance of the treatment plant and the concomitant financial The possibilities and the market potentials of this concept have to be examined.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Convolutional neural networks to reveal resistant phenotypes behind the complex genotypes of ovarian cancer' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

High-grade serous ovarian cancer (HGSOC), which is the most aggressive type of ovarian cancer, is characterized by the mutation of gene TP53 and extensive copy number variations (CNVs). HGSOC tumors typically show an initial favourable response to standard treatments, however they often acquire resistance and relapse. Currently, there is a need for new therapeutic approaches to combat emerging drug-resistant subpopulations. Although, the scarcity of common targetable oncogenic mutations has complicated the development of directed therapies, the study of CNVs offers a promising opportunity to find new mechanisms of resistance and develop alternative treatments, as it has been described how CNVs can model clonal fitness and therapeutic resistance in other types of cancer.Here, I will explore the impact of the CNVs on the treatment response of HGSOC patients and their distal effects on the transcriptome using convolutional neural networks. This complex machine learning model will be trained with the largest available longitudinal cohort of HGSOC samples at the single-cell resolution and will reveal which CNVs, and their specific combinations, have a relevant role in shaping the HGSOC tumours upon treatment. Employing a systems biology approach I will identify convergent phenotypes within these relevant CNV profiles and then validate their effects on treatment using data from both external cohorts and drug-treated patient derived organoid models. This novel approach enables revealing resistance mechanisms driven by complex genotypes, and thus allows finding specific vulnerabilities to combat emerging resistance in HGSOC.


**Keywords:** Copy number variation, ovarian cancer, single-cell transcriptomics, machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Investigation of the structure of the intermediate electron acceptors in photosystem i using continuous wave and pulse electron paramagnetic resonance spectroscopy (epr)'.

assistant: **Concept**

The objectives of this proposal are to elucidate the electronic structure and determine the relative positions and orientations of the intermediate electron acceptors in the photosystem I reaction centre. Electron paramagnetic resonance (EPR) spectroscopy will be used to characterise the radical anions of these acceptors. Continuous wave, including high-field, EPR, applied especially to oriented samples, should provide geometric information regarding their relative orientations. Pulsed EPR spectroscopy will be used to detect possible hypefine interactions arising from nearby nitrogen atoms of the protein surrounding. Their 'fingerprint spectra' will form the basis for specific site-directed mutagenesis. These point mutants should provide an insight into the binding site of the acceptor molecules in the protein especially with regard to their function. This proposal would provide me with a unique opportunity to learn and apply the most powerful techniques of genetic engineering and to perform experiments using the most current approaches of biophysical analysis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pss information network' (PSS).

assistant: **Innovation**

The Product Service Systems Methodology proposal aims to provide industry with a toolkit that enables them to analyse newly developed product-services with regard to design and implementation aspects; micro-, meso- and macro-economic impacts; social and environmental impacts and issues related to consumer acceptance and culture and ethics. The project outcome will offer companies the tools to successfully implement new product- services that will be in line with their business goals, offer optimal quality for their individual customers and minimise negative impacts on the environment, thus resulting in sustainable growth. The toolkit will be developed by leading researchers in the field of Product Service Systems methodology, in close co-operation with industry participants who will provide up-to-date input of business cases and participate in testing and refinement of the developed methodologies and tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design of low nickel stainless steels' (1994-1998).

assistant: **Concept**

Research objectives and content The aim of this project is to analyse and study a specific compositional range of alloying elements in order to develop austenicferritic duplex stainless steels of lower nickel contents than are found in existing 22% Cr duplex alloys in such a way that the proposed l formulations will exhibit an optimised balance between properties (mechanical, corrosion resistance and weldability), fabricability and l production (process and raw materials) cost. Said alternative duplex alloys will primarily feature lower nickel relative to the standard duplex grades in hand, and higher contents of l nitrogen, manganese and copper. Accordingly, the overall composition will be modified so that, while at least matching the common l mechanical and corrosion resistance properties, there is a solidification (porosity and castability) problem, or hot workability loss, and the | trend to brittle phase precipitation is reduced. Heat treatments will be studied in detail for designing the phase balance and phase l compositions towards optimum corrosion resistance and also for a better understanding of the kinetics of precipitate formation influencing corrosion resistance and other properties. Special emphasis will be paid to the welding area. The project is intended to disclose the actual effects of alloying elements on the austenite-ferrite microstructure and properties of these alternative duplex alloys, when they are subjected to different thermal and/or mechanical treatments, for the issue has received little study, sometimes leading to contradictory conclusions, and is clearly deserving of more attention because of its significance for new alloy designing. The main concern in the research program proposed is the determination of partitioning coefficients for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Inspektoren - sustainable refurbishment europe' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Problems to be solvedIn the member states there are about 80 000 residential areas and 56 million flats that have been built since 1950. At the moment 170 million people are living in post war mass housing areas. As the consortium well knows, housing companies need to periodically re-furbish their housing stock and the demand for sustainable refurbishment is high - both from EC and the member states. Today there is no integration of refurbishment strategies with sustainability and not enough participation of tenants. Many refurbishment processes are only focused on technical issues and initial costs.Scientific objectives and approachSUREURO will provide housing companies with practical management tools for integrating sustainable development and tenant participation in their refurbishment management process without exceeding the normal costs for the tenants, who are taking part in the project. SUREURO will also develop design tools for construction companies, designers and engineers; models for better planning, design and technical specifications of refurbishment projects. Finally SUREURO will test and implement new, flexible technical concepts for sustainable transformation of existing housing areas. The result is a unique and innovative knowledge based information system for the total process. The partnership consists of seven big housing organisations from seven different countries within the European Community. To assist the housing organisation in the project there are several research organisations and industrial companies also involved. The project consists of six work packages.The first three are the technical work-packages working in six steps:(1) conceptual process models,(2) inventory of existing tools and technologies (best practises within the seven countri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Multicomponent Protein Cage Co-Crystals' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The possibility to direct nanoscale structural order in complex matter is an important prerequisite for the preparation and characterisation of next-generation functional materials. Hierarchically ordered multicomponent materials are particularly interesting in this respect, since they allow controlled integration of different nanoparticle/material building blocks into periodic nanostructures with lattice constants that are much shorter than the wavelength of light. However, most of the current nanostructured materials consist of fully synthetic or biological materials since the integration of biological and synthetic building blocks in a designed manner remains a challenging task. Here we propose an approach based on the co-assembly of biological protein cages and synthetic materials to bridge the gap between ordered synthetic materials and biological assemblies. Protein-based nanocages, such as ferritins and virus capsids, offer a complex yet monodisperse and geometrically well-defined cage that can be used to encapsulate different materials. We will utilize ferritin and virus particles as a size constrained reaction vessels to prepare monodisperse iron oxide nanoparticles and combine these electrostatically with synthetic noble metal nanoparticles to yield diverse crystal arrangement with coupled magnetic and plasmonic properties. During the course of the project, we will address important challenges, such as how to design responsive and collectively behaving biohybrid materials and to push the research and results beyond the current state-of-the-art. We aim to achieve this by using unconventional methods in designing, synthesising and applying new functional materials whose interactions and co-crystalline packing with biomacromolecules can be controlled. Potential o