RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Brain computer interface for the control of rehabilitation robots, prostheses and paralysed limbs' (BRAINROBOT).

assistant: **Innovation**

Future prostheses and rehabilitation robots for disabled people with quadriplegia, ALS or similar handicaps will be controlled by signals derived from the brain or intact muscle nerves. Problems are the low bandwidth of the signal coupling and the high level of disturbances. Non-invasive multimodal derivation of brain as an input for an intelligent user interface will be used. The Brain Robot Interface must also include tactile and audiovisual feedback from the robot system to the user.The Institute of Automation (IAT) which is specialized so far in robot control and computational intelligence intends to build up strong experience in derivation and interpretation of brain signals for the future control of rehabilitation robots and artificial limbs. It is intended to employ three experienced biomedical engineers for 2 years each and to send four staff members with electrical engineering/computational intelligence background to leading biomedical institutes in Great Britain, Italy, Swiss, Austria and France.With this TOK it will be possible to acquire and integrate the necessary knowledge in biomedical engineering at the IAT and to do research in the area of biomedical signal processing and brain computer interfaces. The state and city of Bremen are within a dramatic change of industrial structure from shipbuilding to more high technical activities. Shipbuilding industry is since several years in a sharp decline and also international trade with trading vessels is under high pressure for a structural change.The state of Bremen founded a RTD project to improve its position within the German and European high tech regions and to overcome the decline of traditional industries. Bioengineering and Biotechnology have been identified as an important part for future development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Photon Cross Correlation Spectroscopy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Across Europe, nearly 250,000 people die every year of sepsis, a severe bloodstream infection. Detecting molecular biomarkers indicative of bacterial infection within a limited time is vital to enable targeted antibiotics therapy, limit the risk of antimicrobial resistance and reduce hospitalization costs. The key to success to fight sepsis is a fast detection technology that avoids the need for nucleic acid amplification processes and circumvents the limitations of fluorescence labelling. The PHOCCS project aims at exploiting novel concepts based on PHOton Cross Correlation Spectroscopy to develop a breakthrough platform for ultra-sensitive detection of DNA biomolecules and assess its transferability into the large molecular diagnostics market. With its unique technology based on dynamic light scattering of noble metal nanoparticles, PHOCCS has several key advantages to enable commercial success: it is fast, quantitative, sensitive, specific and simple to operate. Based upon original and patented intellectual property, PHOCCS is fully targeted to the development of a disruptive technology fundamental in strategic applications of molecular diagnostics to fulfil the industrial market needs. The PHOCCS project will bring the technology to a pre-demonstration stage for DNA sensing to strengthen the commercialization and licensing opportunities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Contaminants of emerging concern: An integrated approach for assessing impacts on the marine environment' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

CONTRAST will develop an integrated assessment and effect-based monitoring framework (IAF) to measure the impacts of CECs on the marine environment to provide a measure of Good Environmental Status for application in EU policy (i.e. MSFD/WFD). The IAF will involve chemical measurements together with biological effects endpoints that will be optimised to detect the presence and degree of effect of CECs in the marine environment. CONTRAST will identify the CECs that pose the greatest threat to marine life by using chemical prioritisation schemes to inform which of the CECs should be measured in the environment. Additionally, which CECs should be used in the laboratory-controlled experiments, where the effects on biological systems and marine biodiversity will be performed. A combination of in silico, in vitro and in vivo bioassays together with omics will be used to determine the principal mechanisms of toxicity of CECs selected from the chemical prioritisation schemes. This will provide important information on how CECs may interact with marine organisms at environmentally relevant concentrations and inform which biological effects tools should be used in the IAF to cover the range of toxicity mechanisms that CECs produce. CONTRAST will address this by optimising existing and developing new biomarkers, so that the IAF includes biomarker tools to cover many of the mechanism of toxicity produced by CECs. A series of European wide case studies will be used to test the suitability of the IAF to measure the effects of chemicals including CECs on indicator species and biodiversity. The knowledge gained from field testing and laboratory studies will form the basis for guidance documents and policy briefs on the best practices for performing an IAF on CECs in the marine environm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European virtual institute for geometry measurements' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Virtual Institute EVIGeM consists of a dense net of European partners, that assists and helps members and any external party on all kind of problems concerning geometry measurements. EVIGeM will join the interests of clients", requesting metrology expertise and instrumentation with the" providers", offering these technologies. The offered support is listed in a supply catalogue, comprising services on the spot and via internet, mediated consultation and education and a business-to-business platform enabling e-business (on-line services, intranet-bourse, selling support).5 thematic groups (each about 10 members) are installed (CMM, Form,Gear,Surface, Medicine). EVIGeM as a future legal entity aims at a self-financing status. A bonus and reward system will encourage members to contribute to EVIGeM's prosperity."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimizing multifunctional forest-based value chains with single tree information and application of digital technologies' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

European forests, pivotal in the bioeconomy and provision of ecosystem services, face growing challenges from climate threats, impacting their multifunctional roles from carbon sequestration to biodiversity and recreation. ""SingleTree"" seeks to transform forest management, aligning with the EU’s Bioeconomy Strategy, Rural Vision, Biodiversity Strategy, and the European Green Deal. SingleTree leverages cutting-edge data capture and AI technologies to monitor individual tree attributes, health, and biodiversity ensuring a holistic approach to multifunctional forest management. By developing solutions for forest health monitoring and wood quality control, the project aims to enhance sustainable forest management, considering the diverse European and regional forest varieties. Data acquisition across the value chain, from forest operations to wood processing, will be optimized, aiding decision-making processes, from harvesting timings to treatment options.  Using a co-creation approach with Living Lab value chains, the project quickly develops solutions addressing real-world challenges. It focuses on boosting forest resilience, preventing biodiversity loss due to climate change, and maximizing the use of different wood grades. SingleTree prioritizes the full utilization of forest biomass, highlighting the carbon retention of premium wood. Furthermore, SingleTree will assess the environmental and social impacts of its innovations, focusing on biodiversity enhancement, resource efficiency, and the implications for stakeholders. The project encourages regional and local entities, particularly SMEs, to adopt innovative business models emphasizing sustainability, circularity, and tiered biomass use. This strategy enhances material utilization and highlights the balance of trad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hyperproinsulinaemia - the molecular basis for two novel genetic syndromes of defective prohormone processing' to be submitted under Fourth Framework.

assistant: **Abstract**

The understanding of the molecular mechanisms whereby prohormones are processed to mature hormones has been greatly enhanced by the identification and characterisation of two subtilisin-like prohormone convertases, PC I and PC2. both of which cleave prohormones at the carboxyl end of dibasic sequences. In the proposed host laboratory, two families have recently been identified in which primary disorders of prohormone processing appear to lead to complex endocrine pathologies. In Family 1, the pattern of defective prohormone processing strongly suggests a defect in the activity of the prohormone convertase PC 1, whereas in Family 2 the biochemical feature are more suggestive of a defect in PC2-mediated prohormone cleavage. The objectives of the project are to examine the genes encoding PC I and PC2 for mutations in these families and subsequently to examine the relevant genes in other families with similar phenotypes. To achieve these aims the following studies will be performed. I . As the orgamsation of the human PC I gene has not been established, the first step will involve the characterisation of the intron-exon boundaries of the normal human PC1 gene by PCR from an available YAC clone containing the entire PC 1 gene. Using the information derived from these initial studies, the nucleotide sequence of the PC I coding region in the proband of Family 1 will be determined by direct sequencing of each exon amplified by PCR. 2. The human PC2 gene has been characterised and a highly polymorphic CA repeat identified. The cosegregation of this polymorphic marker in the PC2 gene with the disease in Family 2 will be studied. If there is evidence that the PC2 gene could be linked to the phenotype in the Family 2, then the nucleotide sequence of the coding region of PC2 will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Illusions in the thermo-nociceptive system'.

assistant: **Innovation**

What does it mean to experience an illusion of pain? The typical role of pain is to signal when the body is damaged. However, pain illusions in the absence of any risk of tissue damage are common in the normal population. For example, a mix of warm and cold stimuli can be perceived as burning hot, as in the case of the Thermal Grill Illusion. So far, research on thermosensation and pain has largely treated pain illusions as curious quirks of the thermo-nociceptive system, and underplayed the fact that these illusions fundamentally contradict core assumptions of mainstream theories of pain perception. In this project, I propose a new approach to advance our understanding of perceptual inference of pain in humans which challenges these assumptions. Specifically, I will use behavioural and neuroimaging experiments to identify the functional properties, clinical relevance and neural basis of both illusory and veridical pain. First, I will extend innovative behavioural, physiological and neuroimaging protocols to investigate the mechanisms underlying pain illusions. Next, I will investigate the clinical relevance of illusory pain, with the ultimate goal of providing novel tools that can offer a mechanistic approach to pain assessment. Finally, I will validate a comprehensive computational model of pain, which can explain both illusory and veridical thermo-nociceptive phenomena in a unified framework. Overall this project will harness pain illusions to uncover general principles of temperature and pain perception, and will validate novel computational techniques for characterising the neural encoding of thermosensation and pain. These outcomes will redefine our understanding of illusory pain and offer new insights into mechanisms of temperature and pain perception in humans.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Sustainable Liquid Biofuels from Biomass Biorefining'.

assistant: **Concept**

SUNLIBB brings together key researchers and industrial innovators working to overcome technical barriers all along the pipeline for second generation bioethanol production. The range of research spans from feedstock improvement, through innovations in pretreatment and saccharification, the generation of added value products, especially from lignin, and innovations in fermentation. The project brings together world-leading scientists with innovative new industries working in the biorefinery and renewable products areas. Our work is focussed on C4 grasses as these encompass maize, miscanthus and sugarcane, and these closely related species are major bioenergy crops in Europe and Brazil. The programme of work aims to: (1) Improve the feedstock quality of lignocellulose in biofuels crops to allow truly cost-effective ethanol production; (2) add value to the overall process of conversion in biomass biorefining by upgrading residues and by-products and producing new value streams in addition to bioethanol; (3) improve the conversion process by which we produce sugars; (4) improve fermentation efficiency; (5) develop integrated processes that capture maximum value from lignocellulosic biomass; (6) ensure that the new processes developed fulfil sustainability requirements by reducing GHG emissions, cutting other forms of air pollution, have minimal impacts on local environments and biodiversity, build sustainable rural industries, and do not impact on food production and prices. Our cooperative partner in Brazil, CEProBIO, brings together almost all of the leading research centres for second generation bioethanol production in that nation, along with a number of key industrial partners. The cooperation between SUNLIBB and CEProBIO represents an opportunity to bring together som
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Unique stand-alone software based on mesh morphing technology for fast and accurate Computer Aided Engineering to develop safer and greener products.' under Horizon 2020.

assistant: **Concept**

Computer-Aided Design (CAD) is the usage of computer software to create precision drawings or technical illustrations.Computer Aided Engineering (CAE) software is used to optimize such designed models by simulations in order to improve product performance or assist in the resolution of engineering problems for a wide range of industries. The CAD model needs to be adapted all through the CAE simulation several times, making this step very complex with existing solutions. This limits the present adoption of CAE to niche high value products in Automotive, Healthcare and Energy industries. RBF2CAD is a unique stand-alone software based on mesh morphing technology that combines a very accurate control of the geometrical parameters with an extremely fast mesh deformation for all CAD designs, fully integrated in the Computer Aided Engineering (CAE) solving process. RBF2CAD at its core aims to provide a solution which can leverage the latest technologies for computing and provide extremely fast mesh deformation platform. Further the stand-alone platform will provide a user-friendly and cost-effective way to enable wider access to mesh-morphing across the CAE ecosystem. The potential users for RBF2CAD are CAD and CAE engineers working at large corporations. RBF2CAD will be highly useful in the automotive, aeronautical, additive manufacturing and healthcare industry. RBF2CAD intends to take up feasibility studies in two major areas for the Phase 2 project namely Technical and Business Feasibility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Joint Exhibition on Evolution'.

assistant: **Objectives**

The Deutsches Hygiene Museum is developing a special exhibition, which will take an interdisciplinary look at the idea of evolution. The latest findings and controversies surround modern evolutionary theories will be highlighted. The exhibition aims at promoting the understanding of the mechanisms underlying evolutionary events as well as the understanding of why evolution matters in our daily lives from antibiotic resistance, SARS, genetically modified foodstuffs to creationism.Both partners wish to work together on the project of shipping the exhibition to Citt della Scienza in order to promote a transfer of information on a subject relevant to both institutions and their audiences. This transfer will support the dialogue between science and society and help to promote a common understanding on issues important for Europe as a whole. The exhibition needs to be transported and adapted to the second venue. Panels, labels and other written materials have to be translated. A website will link both events. The staff needs to be trained in the fundamental issues and specialities of the exhibition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Unfoldomics of the cellular stress response: How do intrinsically disordered chaperones work?'.

assistant: **Innovation**

One of the key issues in biology is determining the mechanisms underlying the response of organisms to changes in their environment. It is known that ability of cells to sustain and recover after stress conditions depends on a well-developed and complex network of protein chaperones and co-chaperones. This proposal addresses fundamental questions in a recently discovered subgroup of molecular chaperones, intrinsically disordered chaperones, which use plasticity for their ATP-independent chaperone function.Intrinsically disordered proteins (IDPs) are widespread and fulfill important functions associated with signaling and regulation. Although intrinsically disordered protein are considered to be a crucial part of the proteome, most experimental and computational studies have focused on the contribution of intrinsic disorder to signaling and assembly of multi-domain complexes, leaving molecular chaperones as an unexplored niche. The involvement of intrinsic plasticity in molecular recognition is usually explained by such terms as promiscuity and flexibility. Beyond these notions it still remains unclear why specific intrinsically disordered protein were selected to recognize signaling proteins, DNA, small ligands or aggregation-prone proteins. In this proposal, we aim to explore the putative links between intrinsically disordered regions (IDRs) and chaperone activity. In order to establish such links we propose to utilize innovative and multidisciplinary approach, which combines chaperone biochemistry, protein design, bioinformatics and state-of-the-art mass spectrometry to elucidate the central role of protein plasticity in maintaining protein homeostasis during stress conditions. This proposal will be based on the experiment-driven approach: computation will point the w