RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A next-generation platform for catalysing pre-clinical development of drugs against Alzheimer’s and other degenerative diseases of old-age' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Degenerative diseases of old age, including cardiovascular diseases, type II diabetes, and chronic respiratory conditions, have emerged as the major causes of death in EU countries. Of special concern are neurodegenerative conditions including Alzheimer’s and Parkinson’s, which have been described as the greatest unmet need facing modern medicine. Developing new therapies to slow, halt, or reverse these pathologies is regarded as a key element in addressing this global health priority. No such therapies have been successfully developed to date.A major unsolved challenge faced by drug discovery organisations is that for most degenerative conditions, there are no prognostic markers that can be used to predict whether a candidate therapy is likely to improve clinical outcome.Our solution to this problem exploits the fact that the pathogenesis and progression of all degenerative diseases is associated with oxidative stress. Oxidative stress thus makes an excellent potential prognostic biomarker, but it has been difficult to measure in vivo. Now, under the REDOX ERC Advanced Investigator Award, we have developed a portfolio of next-generation mouse models in which oxidative stress can be monitored at single-cell resolution across all organs. Moreover, the measurements can also be performed non-invasively and in real-time. We believe that these mice provides a new platform with unprecedented utility that can be used by drug-discovery organisations to accelerate, reduce the costs, and increase the predictive power of their pre-clinical pipelines for degenerative conditions. To support commercial exploitation of these models, we will:a) Show that our oxidative stress biomarkers are elevated in mouse models for two degenerative conditions, Alzheimer’s and Hutchinson-Gilford Prog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'QuickMIC™ - an ultra-rapid diagnostic system for Antibiotic Susceptibility Testing (AST)' in the context of a Horizon 2020 call.

assistant: **Objectives**

The aim of the project is to bring QuickMIC™, an ultra-rapid diagnostic tool for Antibiotic Susceptibility Testing (AST) to the market and clinical practice. AST is usually carried out to determine which antibiotic will be the most appropriate in treating a bacterial infection in a particular patient.  Sepsis is the major cause of death as a result of an infection today. It affects approx. 30 million of people every year worldwide. About 20 % of the patients do not survive the disease. Currently, it can take up to 48 hours for the current golden standard AST method to produce reliable diagnostic results. Therefore, doctors empirically treat sepsis patients with wide-spectrum antibiotics while the blood samples are being tested. The globally escalating antimicrobial resistance (AMR) has resulted in empirical treatment being unsuccessful more and more often. Misuse of antibiotics  additionally contributes to increasing resistance. The improvement of survival rates in sepsis and the decrease in AMR will only be possible with access to a quicker AST tool. To address this unmet clinical need, Gradientech is developing an ultra-rapid AST system, QuickMIC™, based on a patented technology platform. By combining i) advanced microfluidics and ii) continuous image detection and analysis, QuickMIC™ can reduce the time of an AST to two hours. Besides being the fastest AST under development, QuickMIC™ is also a low-price alternative compared to its direct competitors. By commercializing QuickMIC™, Gradientech will make an important contribution to fighting AMR in Europe. Moreover, we will significantly improve the diagnosis and treatment of sepsis. A continued development of QuickMIC™ will result in a CE-IVD marking by early 2019. In the Phase 1 project, we will develop a business pl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Eye fundus colour images enhancement service for Diabetic Retinopathy diagnosis' to be submitted under Horizon 2020.

assistant: **Abstract**

Diabetic retinopathy (“DR”) is considered as a priority eye disease by the World Health Organisation, as one of the main causes of visual impairment. It is a complication of the eye that can affect anyone who has diabetes. Diabetic retinopathy causes damage to the blood vessels supplying the retina – the “seeing” part of the eye. Because retinopathy generally has no obvious symptoms until it is advanced, early detection is essential. Detection is made by retinal screening. This is a straightforward procedure which includes assessment of visual acuity and eye fundus photography. Then a medical specialist, who looks for signs of diabetic retinopathy, gives a grade allowing a further diagnosis. This makes the diagnosis heavily dependent on the image quality. iPRI, which current activity is based on consulting expertise in public health, has identified a need for delivering a practical solution to the DR diagnosis challenge. iPRI has created a new prototype of software to enhance the quality of colour eye fundus exams. Several tests on representative databases have shown to DR experts that there is an important medical interest to introduce this service in the diagnostic procedure. IPRI’s international network of Key Opinion Leaders in Diabetes has confirmed this interest. Through the EYE-LIGHT project, iPRI aims to integrate this proven technology into a medical device. It will be provided as a professional application software service in order to facilitate the DR diagnosis, improve the image quality, allow comparisons and make images sharable through telemedicine. In order to address the unmet medical need, iPRI has to scale up, industrialise and sell this medical device. Through the SME Instrument programme, iPRI intends to refine the business model of this new activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Nanocluster-sensitised optical waveguide amplifiers and lasers'.

assistant: **Innovation**

The goal of this proposal is to assess the viability of silicon-sensitised erbium doped materials systems for optical device applications. Our work will focus on silicon nanoclusters of 2-4nm diameter that possess novel optical properties, including the ability to efficiently transfer optical excitation to nearby luminescent species. We aim to exploit the optical sensitisation effects of these nanoclusters, which allow us to couple into Er ions far more effectively than is possible in conventional rare ear th-doped glasses. The broad absorption spectrum of the nanoclusters and their very large excitation cross-section will enable us to develop planar optical devices that are pumped in a top down configuration using cheap broad-band sources such as LEDs.Compared to the expensive lasers currently used, we stand to achieve a potential 100-fold reduction in pump power costs by deploying LEDs instead, opening the door for such devices to find applications in local area networks. An amplifier in a waveguide geometry can also allow the fabrication of complex integrated optical circuits, and combine them with silicon technology to achieve electro-optical signal conversion. The erbium-doped silicon-rich silica material will be first characterised and the transfer mechanism will be studied; the fabrication parameters will be varied in order to optimise the efficiency and reduce possible excited state absorption processes. Then, channel waveguides will be characterised (optical gain, scattering, absorption...) under different pumping conditions. The final aim of the project is to demonstrate LED-pumped waveguide amplifiers and lasers in the 1.5 micron range.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Biopolymer-based microstructures for improved food quality' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Product Microstructure Unit at Unilever Colworth has an international reputation for research in the area of structural and functional properties of biopolymer systems to deliver better quality emulsion, foam and frozen food products that are desired by and beneficial to the consumer. Projects are available in the areas of microstructure characterization and control in mixed biopolymer systems and food microstructure design for in-body function. Working as integral members of multidisciplinary project teams, the Fellows will obtain industrial research training, and will develop expertise in the physical chemistry of polymer solutions including kinetics of gelation, thermodynamics and kinetics of polymer incompatibility, the materials science of soft solids, and the behavior of small molecules within complex microstructures. They will learn how this information can be applied to food products, and how manufacturing process conditions affect the final microstructures of food materials as well as their breakdown and oral response. Fellows will be trained in industrial research project management. They will receive training in the use of a range of state- of-the-art instrumentation and techniques (e.g. rheology, scattering, microscopy, calorimetry) as well as pilot plant equipment. Unit scientists collaborate with many external academic groups, both in the UK and internationally, and Fellows will also have the opportunity to access expertise in this network.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Bridging Minds: Disability and Friendship since the 1960s from a Transnational Moral History Perspective'.

assistant: **Concept**

According to a 2023 survey, 24% of the global population felt “very lonely”. This percentage is even higher in the case of marginalized groups: research suggests that up to half of persons with cognitive disabilities experience loneliness, despite their emancipation after the 1960s. Attempts to reduce their loneliness have only limited success, because we do not fully understand why people with cognitive disabilities experience more loneliness than the general population. What academic research in particular lacks are studies about interpersonal (dis)connections between people with and without cognitive disabilities over a longer period of time and in different places in the world. The challenge of writing the history of interpersonal connections will be faced by the transnational moral history of friendships between people with and without cognitive disabilities this project entails to write. DisFriend will follow and contextualize how influential international organizations and communities in which people with and without disabilities have lived and worked together in countries all over the world, constructed, practiced and strived for friendship as a “moral good” since the 1960s. By investigating friendship (or a lack of friendship) in five historical case studies, DisFriend will provide a better understanding of why people with cognitive disabilities have experienced more loneliness despite they have been increasingly recognized as fellow citizens. By analyzing under-investigated archival data, published stories, and by conducting oral history interviews, DisFriend will enrich historiography with the history of overlooked but influential counter-hegemonic internationalisms and a rewriting of the history of community care from the perspective of cognitively disabled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the role of the blood-brain barrier in uremic toxins-induced neuropathies' in the context of a Horizon Europe call.

assistant: **Objectives**

Chronic kidney disease (CKD) is estimated to affect more than 840 million people worldwide constituting a major global health crisis. Clinically, the number of CKD patients will continue to rise mostly because of the ageing population and the increased prevalence of comorbidities such as diabetes and hypertension. In Europe, around 100,000 million people are affected by it. According to the gloomy predictions, Europe is at risk of a dismal increase of CKD patients as well as costs to healthcare systems. Patients with advanced CKD display a loss of kidney function leading to a blood accumulation of, a.o. protein-bound uremic toxins (PBUTs) that are poorly eliminated by renal replacement therapies. This systemic retention known as the uremic syndrome affects other organs. Indeed, neurologic complications such as blood-brain barrier (BBB) disruption have been reported in CKD patients. The BBB guarantees the exchange between the blood and the brain through a complex cellular organization and a diverse range of transport proteins mediates the movement of endo/exogenous compounds. I hypothesize that impairment of kidney tubular functionality in CKD causes an alteration of BBB integrity and function. This results in an aberrant BBB pass-through of PBUTs as well as impacts BBB vectorial transport capabilities. This fellowship aims to develop an appropriate multi-organs-on-chip device to accurately describe (i) the impact of PBUTs on BBB integrity and functionality, and (ii) the involvement of kidney-brain axis dysfunction in PBUTs-driven BBB disruption. We will develop a bioprinting-based microfluidic BBB-on-chip to accurately study BBB permeability, architecture, and transport function. This device will be connected to our established proximal tubule-on-chip to form a robust (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Revealing plasticity of developmental cell fate decisions by single-cell RNA labelling' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

Every time an egg is fertilised, the cellular diversity of an animal must be rebuilt from scratch. Therefore, a central question in developmental biology is how cells differentiate to acquire distinct fates. A combination of genetics, molecular biology, and microscopy approaches has led to fundamental discoveries. Recently, single-cell genomics has enabled the analysis of transcriptional differentiation trajectories at unprecedented scale and resolution. However, ordering single cells by transcriptome similarity only gives ensemble averages of differentiation trajectories and not the full spectrum of cell state transitions. It then remains unclear whether cells can commit to their fate at different stages of development or change differentiation trajectories. The sc-LAB2FATE project proposes to measure how single-cell transcriptomes change over time in living zebrafish embryos using a new RNA labelling methodology. This will reveal the full spectrum of differentiation trajectories during gastrulation, allowing to see not only the major routes of differentiation, but also rare alternative trajectories. Single-cell RNA labelling, biochemical nucleoside conversion and sequencing will be used to measure mRNA kinetics and transcriptome dynamics of zebrafish embryos at single-cell resolution. Spontaneous cell fate changes during normal development will be contrasted with induced cell fate changes upon cell transplantation from different cell types to decipher signalling interactions. This project will leverage single-cell genomics and traditional approaches in developmental biology to build a conceptual framework for analysing embryonic development as both a genetically programmed and a self-organised phenomenon, and to provide a general blueprint of how one can study perturb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'INorganic Photochemical PATTerning'.

assistant: **Concept**

Light activation finds a widely spread application to produce photochemically solid organic resins at low irradiation intensity from liquid organic precursors. The main advantages of this process are that it can be activated locally, by focusing a light beam, remotely, and switched on/off easily, in a safe and convenient irradiation regime. For these features, light-activated polymerization is used for patterning organic structures in fields of high technological, economic and social impact such as stereolithography and tooth restoration. Recently we demonstrated that a similar result can be achieved by photochemical generation of an acid or a base in a suitably designed precursor solution and that this approach can be easily extended to inorganic materials such as insoluble carbonates and phosphates. On the basis of these results, our project INorganic photochemical PATTerning (INPATT), hence the photochemically-controlled production of a solid inorganic matrix instead of an organic resin will offer a solution to the market for the problem of patterning inorganic materials with light. The ambitious objective of INPATT is to provide new liquid formulations suitable for applications in stereolithography, patterning, and tooth and art restoration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Activation of bilingualism in anaphora resolution by adult second language learners of Spanish' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This project investigates how two languages interact in the bilingual mind by examining anaphora resolution in L2 Spanish among adult native speakers of Italian and English. Participants are tested in both mono-language and dual-language mode. Specifically, the study assesses how bilingual speakers link Spanish pronouns (null/overt) to their referents during online processing (via visual world eye-tracking) and offline comprehension (via untimed picture-selecton task). The innovation of this research lies in the use of bilingual stimuli (English–Spanish and Italian–Spanish) within the same experiment, allowing for simultaneous co-activation of both languages of participants' linguistic repertoire while they process linguistic stimlu in real time. Results from the dual-language mode are compared with those from a mono-language mode, in which participants are required to suppress one language (Spanish-only). This comparison aims to determine whether language co-activation influences pronoun resolution in bilinguals.By incorporating bilingual input, this project advances beyond most second language acquisition and processing studies, which typically make use of experimental stimuli in one language only, and compare L2 learners to monolingual controls as a normative baseline. However, this approach does not capture the dynamic nature of bilingual cognition, failing to account for the real-life situation of two languages constantly interacting in a bilingual’s mind, and reinforcing the outdated view of bilinguals as two monolinguals in one person.Therefore, this study offers a more ecologically valid framework for psycholinguistic research, avoiding the bilingual/monolingual comparative fallacy. The role of word order and pragmatic factors (topic and focus) in modulating L2
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Alignment of Liquid Crystals on Patterned Surfaces'.

assistant: **Innovation**

Patterned topographies for their potential use as alignment layers for liquid crystals are proposed. Systematically designed nano- and micro surface patterns, as a valuable tool for studying not well-understood liquid crystal/surface interactions and their effective control, will be produced by unconventional patterning techniques. A comprehensive study of the alignment and electro-optical behavior of liquid crystals on such patterned surfaces is proposed. It is expected that the project will shed more light on liquid crystal/solid surface interface and address its role in the static and dynamic behaviour of confined liquid crystals. Also, generation of new concepts for device application of liquid crystals is expected.