RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Otoliths as metabolic loggers: Examining the physiological basis for climate resilience in wild populations of marine fish', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The effect of temperature changes on ecosystems is determined by the physiological responses of individual organisms, but most studies predict responses at the species level. This conceptual convenience allows us to use relatively simple models but does not allow for phenotypic plasticity or adaptation: the extent to which individuals are able to mitigate combined direct and indirect effects of temperature change by modifying their behaviour or energy budgets. The role of phenotypic plasticity in predicting population, species and ecosystem responses to change is one of the most pressing, but challenging areas in modern ecology. The importance of adaptation in moderating the ecological effects of warming in marine systems is very poorly understood. Field metabolic rate (FMR) is the amount of energy consumed by an individual while performing day to day biological functions. An individual’s field metabolic rate therefore integrates a wide range of physiological and behavioural responses to the ambient environment, and is an ideal metric for understanding how individuals respond and adapt to temperature change. Unfortunately, there are major scientific challenges to measuring field metabolic rates in natural conditions. We will meet the challenge of recording FMR in marine ectotherms by exploiting a new biogeochemical measurement field metabolic rate in marine fishes based on the stable carbon isotope composition of otoliths. We will measure metabolic responses of a model organism, the Atlantic cod (Gadus morhua), and test a series of fundamental ecological hypotheses relating between-individual diversity in respiratory physiology to population scale resilience. Our research will break new ground by turning otoliths into internal metabolic loggers and significantly impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Identification and assessment of training needs, methods and activities for the wider use of environmental technologies in key sectors'.

assistant: **Innovation**

With a focus on transport, the project intends to increase the understanding among relevant actors of the benefits of environmental technologies for a wider application of these technologies. It will build on the ETAP actions on targeted training and aware ness raising. Pursuing this aim, the following support activities will be undertaken: ¿ conceptualising and organising of 3 workshops with relevant stakeholders for stock taking, identifying obstacles and possible solutions as well as best practice example s; ¿ organising a concluding conference on the basis of experiences made in the course of the project (to produce recommendations); intended for in particular senior executives within the sector in order to ensure that the learning from the project is communicated at a level that can help to ensure as broad a take-up and dissemination as possible. ¿ producing Background Notes and Policy Briefs on training needs and awareness raising. The Background Notes will serve as a basis for the Conference discussions; the Policy Briefs will disseminate the project's findings and recommendations beyond the project to a wider audience.  specifying a low-cost, easily disseminated e-learning solution that addresses the overall objective of the project: increasing awareness amongst those working in this sector of underlying issues and dilemmas as well as of solutions and good practice. This activity also includes recommendations for routines to maintain the awareness and competence in order to ascertain continuous, long-ter m effects of the efforts. ¿ disseminating widely findings and recommendations of the projects, through the web sites of project partners and active involvement of business and training associations as well as the media.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reductions and exact solutions of    boundary value problems  with moving boundaries  by means of  symmetry based     methods' to be submitted under Seventh Framework.

assistant: **Abstract**

Boundary value problems  with moving boundaries  are widely used  in mathematical  modeling  a huge number of processes, which   arise  in  physics,  biology  and  industry.  While these  processes  can be very different from a formal point of view,  they  have  the common peculiarity: unknown   moving boundaries. The most important subclass of such boundary value problems (BVPs)  is  the  Stefan problems, in which   the movement of  unknown  boundaries is governed by the well-known Stefan boundary conditions.   BVPs  with moving boundaries, particularly    the  multidimensional Stefan problems,   are the main object of the  proposed project.Developing new  theoretical foundations and algorithms   for reduction of  such BVPs   to those of  lower dimensionality  and  construction  of  exact solutions of BVPs in question  is  the main aim  of the project.  Applied  goal  is to compare the analytical  results derived  with those  obtained by means of  the  appropriate  numerical techniques  in the case of  a wide range of  the    physically and biologically motivated problems. Moreover such comparison will demonstrate  the real  interdisciplinary aspect of the proposal. The  novel  idea  of the project  is to develop the algorithms mentioned above using  such  symmetry based  methods as the  classical Lie-Ovsiannikov method, the Bluman-Cole  method of non-classical  symmetry, conditional symmetry method  and  their  recent extensions.The main results to be achieved: new definitions  of  (generalized) conditional  invariance  for   BVPs  with a wide range of  boundary   conditions will be  derived; algorithms  for how to construct  all possible conditional  symmetries for the given class of BVPs will be determined; new analytical results (conditional symmetries, reductions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Characterization of the role of Scrib1 and Vangl2 in neuronal migration' (MigPCP).

assistant: **Innovation**

Although the cerebral cortex is responsible for all the intellectual life that makes us human, we know remarkably little about how this amazing structure is formed. We do know, however, that genetic conditions in which the cortex is not formed properly have devastating consequences. Neurological disorders are frequently associated with developmental brain malformations. Progress toward understanding the pathologic basis of these diseases has so far come from research on animal models of cortical malformation and from molecular genetic approaches to human neuronal migration disorders.The aim of this 3-year project is to elucidate the molecular and cellular mechanisms of one of the Planar Cell Polarity (PCP) genes,Scribble 1 (Scrib1) and Vangl2, in shaping the mammalian cortex. More specifically, the fellow applicant will analyze the role of these genes in neuronal polarity and migration. He plans to use conditional knockout mice combined with advanced cell imaging analysis and in vitro experiments that will synergize to provide a powerful approach to address this goal. We believe that the experiments from this proposal should bringnovel insight into the mechanism by which PCP genes can regulate neuronal migration and cortical development.Results from proposed experiments will bridge our knowledge from molecular mechanism of cortical neuronal migration to the formation of human brain, and will also provide important insight into the pathogenesis of human neurogenetic disorders. The candidate has a background in biomedical science, and has had intensive training in molecular approaches during Ph.D. and postdoctoral training. He now seeks further training in mouse genetics and neuroanatomy under the mentorship of Drs. Mireille Montcouquiol. With help of CIG grant, this trai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Molecular regulation of blood coagulation factor V: from snakes to humans' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The overall goal of this proposal is to provide new information on the molecular mechanisms that regulate the cofactor function of blood coagulation factor V (FV). Shedding light on these processes may provide a framework for developing novel strategies for prevention and treatment in cases of disregulation of the blood coagulation response. This is a uniquely complex process that protects organisms from significant blood loss following vascular damage. A failure of this system to respond or to restrict its response can result in life-threatening bleeding disorders or thrombosis. Coagulation FV plays an important role in the clotting system as precursor of FVa, the cofactor for the serine protease FXa that converts prothrombin to thrombin, a key regulatory enzyme in the formation of a blood clot. Interaction of FXa with FVa dramatically enhances its catalytic rate, highlighting the biological significance of FV.Factor Va only interacts with FXa on a phospholipid surface, such as that of platelets or ruptured atherosclerotic plaques. The exact mechanism underlying the membrane-dependence of this interaction is, despite three decades of FV structure-function research, still poorly understood. In the current project, we aim to address this longstanding question using a novel strategy based on a naturally occurring FV variant found in the venom of the Australian snake P.textilis (pt-FV), which has evolved to circumvent the membrane-dependence in FXa binding. We will target several unique structural features of pt-FV that we speculate are involved in its membrane-independent FXa interaction, which will be a) removed from pt-FV and b) introduced into human FV. By characterizing this recombinant FV panel, we anticipate to gain critical insight into the FVa-FXa enzyme complex t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Chemical Bioanalysis'.

assistant: **Innovation**

Chemical Bioanalysis aims for retrieving selective information out of complex biological systems. Sensors, probes and devices are the future tools of medicinal diagnostics, environmental monitoring, food analysis and molecular biology. The ITN CHEBANA provides interdisciplinary research training for early stage and experienced researchers and focuses on the most important techniques in the field. These are based on fluorescence, electrochemistry and mass spectrometry. Eleven excellently qualified academic partners (with well documented expertise) along with one of Europe’s leading industrial companies in the diagnostic area will provide a network of research activities, short courses and classes that are complemented by skill training and career development events. In fact, we believe that we have unified Europe's leading experts in these fields, many of which outperform their American and other colleagues. Moreover, joint research projects between the partners build the foundation of the training network.The research activities are divided into four overlapping areas:* sensor development for the detection of small analytes,* monitoring of biomolecular interactions,* analysis of cellular function, and* development of diagnostic tools.Interdisciplinary expertise and specialized techniques are mandatory in order to accomplish these challenges, and this cannot be provided at a single institution at the required level. Therefore, a European hub for research and training in the fast developing field of Chemical Bioanalysis is assembled by co-supervised PhD theses, postdoctoral training, workshops and summer schools bringing together the individual expertise of the partners from academia and industry. Eventually, this ITN will provide highly specialized experts that are urgen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Network of Rural Areas Aiming at Very-high RE Rate' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The aim of this project is to give the participating areas a strong impetus for achieving their goal of a 100% RE-based energy supply through solving a number of RTD problems they are facing, thereby improving the regional and EU-wide environmental, social and economic situation. First, visible results in these areas should motivate similar areas in Europe to follow their example. The objective is to do R&D on the change of the energy system of rural areas into a sustainable one which is based on RE.The work will focus on some of the major missing links - technical, financial, social, structural- which opposed the straightforward use of local, renewable energy sources in these areas. Best practice of achieving high RE penetration levels in rural areas will be developed. An internet-based Virtual 100% RE-NET with information, communication and benchmarking features will be developed and tested.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Establishing the Hungarian Center of Excellence for Molecular Medicine in partnership with EMBL' (HCEMM) targeting Horizon 2020.

assistant: **Abstract**

After having identified the barriers hindering European level competitiveness in the field of molecular medicine for Hungary, the University of Debrecen, the University of Szeged, the Semmelweis University and the Biological Research Center of the Hungarian Academy of Sciences united to create the Hungarian Centre of Excellence for Molecular Medicine (HCEMM). They were joined by the National Research, Innovation and Development Office representing the Hungarian Government as project coordinator and by the European Molecular Biology Laboratory as leading scientific institution.The goal of creating HCEMM is to develop a “game changer” organization in the form of a non-profit Ltd. which catalyzes reforming changes in the research culture and makes impact in the regional development of three Hungarian “knowledge regions”. The organizational and management model will ensure autonomy and scientific excellence with an international evaluation system. Research groups will be pursuing in cross cutting fields and will be reviewed every 5 years in order to ensure scientific excellence. Advanced core facilities, effective technology transfer and vibrant links to industry will also be provided. The headquarters will be in Szeged and the research groups will be located in state of the art facilities in Szeged and in Budapest. EMBL and HCEMM Nonprofit Kft. will conclude a partnership agreement, ensuring a continuous transfer of institutional, research and collaborative expertise, and access to the EMBL partnership network in Europe and beyond. Financing stability of HCEMM will be based on 52 M € coming from H2020 Teaming, the Hungarian Government and the founding institutions. For the long term sustainability the Governmental commitment and the financial support of the founding instit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Policy recommendation and improved communication tools for law enforcement and security agencies preventing violent radicalisation' (Pericles), addressing dissemination and exploitation.

assistant: **Impact**

The overall aim of the proposed project is to develop a comprehensive approach to prevent and counter violent radicalisation and extremism. The PERICLES (Policy recommendation and im-proved communication tools for law enforcement and security agencies preventing violent radicali-sation) project is especially dedicated to transitional processes of radicalisation. To meet its aims, PERICLES will consider violent left-wing and right-wing as well as religious ideologies. A special focus will be set on the risks connected with digital violent propaganda. The PERICLES project will deliver advanced and validated counter-propaganda techniques that are target-group-specific. Furthermore, the cooperation between relevant authorities who have due regard against violent rad-icalisation or support the process of de-radicalisation will be enhanced through the use of the project outputs. The comprehensive PERICLES prevention strategy will therefore largely address law enforcement agencies (LEAs) and security agencies; but will also find use by prisons and social workers, teachers and even relatives of affected people.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global Dynamics of Proteolytic Quality Control Networks in Stress Response and Aging' (PROTEODYNAMICS).

assistant: **Concept**

Accumulation of damaged and aggregated proteins is associated with age-related neurodegeneration in Alzheimer’s and Parkinson’s patients. The ubiquitin/proteasome system (UPS) is a major proteolytic route functioning in a cellular network that maintains the proteome during stress and aging. Degradation of damaged proteins is mediated by the 26S proteasome upon attachment of ubiquitin (Ub) proteins (ubiquitylation). Another proteolytic system supporting protein homeostasis (proteostasis) is the autophagy-lysosome pathway that degrades proteins inside activated autophagosomes. An age-related impairment of either of these systems causes enhanced protein aggregation and affects lifespan, suggesting functional overlap and cooperation between UPS and autophagy in stress and aging. Despite the progress made in searching for key substrates that are destined for degradation, the major challenge in the field is to understand how these proteolytic systems are mechanistically coordinated to overcome age-related proteotoxicity. The ultimate goal of the proposed research is to assemble a global picture of stress-induced proteolytic networks critical for aging of multicellular organisms. The tissue-specific regulation of protein degradation pathways will be addressed using the powerful genetic model of Caenorhabditis elegans. The suggested project will systematically analyze: inducible protein degradation pathways (Aim 1), the regulation of UPS and autophagy by microRNAs (miRNAs) (Aim 2), and tissue-specific adaptation of proteolytic networks (Aim 3) in stress response and aging. To this end, comprehensive transcriptome analysis, large-scale genetic screenings combined with deep-sequencing technology, and candidate approaches based on in vivo imaging and degradation assays will be per