RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Markers for Sub-Clinical Cardiovascular Risk Assessemnt'.

assistant: **Concept**

EU-MASCARA is a collaborative project that aims to improve diagnosis of cardiovascular diseases and prediction of cardiovascular risk by analysing a panel of biomarkers. EU-MASCARA aims to examine genetic, proteomic and metabolomic markers together with markers of inflammation, oxidative stress and cardiac remodelling to study their incremental diagnostic and predictive value over and above existing diagnostic and predictive algorithms. For this purpose a large number of cohorts from different European regions, both patient and population cohorts, that have been accurately assessed for cardiovascular phenotypes are readily available to the consortium. Access to clinical samples and to standardised cardiovascular phenotypes will be granted by a strong clinical platform as one of the key work packages of EU-MASCARA. Both cross-sectional and prospective analyses will be performed that will result in the development of improved risk prediction scores. The consortium is heavily supported by contributions of SMEs in key areas of the proposed research: biomarker testing, data handling and analysis, assay development and project management. EU-MASCARA is further characterised by a strong integrative approach both within and across work packages, with results from one task informing strategies of research in other tasks. With a dedicated bioinformatics and health economic platform the most robust biomarkers will be selected and analysed for their benefit in clinical practice. EU-MASCARA will rigorously validate biomarkers that have been proposed to be associated with cardiovascular disease and risk across different disease entities and also in independent general population samples. The most robust biomarkers will be implemented in novel biochip based assays for clinical use.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Design of original Silicon-based multielement electrocatalysts for CO2 reduction'.

assistant: **Innovation**

The electrochemical CO2 reduction reaction (CO2RR) is a promising approach to producing sustainable fuels or chemical products from anthropogenic CO2 emissions. It can use electrical power generated by renewable sources to deliver valuable multi-carbon molecules (e.g., ethanol, propanol) and store energy in chemical bonds. Electrocatalysts needed to accelerate and make industrially viable this reaction suffer from poor selectivity among multi-carbon products. Our aim with SILICOR is to design a new family of nanocrystals with tunable chemical bonding to adjust the selectivity of CO2RR electrocatalysis. The target multielement nanocrystals will associate four chemical elements, specifically copper, prone to deliver multi-carbon products, another transition metal (e.g., nickel), and two p-block elements, silicon and phosphorus. These Cu-based silicophosphides will exhibit adjustable chemical bonding, from metallicity through ionicity to covalence, to adjust the electronic and geometric environment of copper catalytic sites and then adsorption of reaction intermediates, hence the selectivity. These original nanocrystals will be designed by the diffusion of Si and P atoms inside bimetallic Cu-based alloy nanoparticles. This novel approach of converting alloy nanoparticles will be enabled by an innovative liquid-phase synthesis approach where the nanoparticles will be dispersed into molten salts that will activate the diffusion processes. This work at the edge of nanosciences, electrocatalysis, and energy conversion will deliver new materials for the valorization of carbon dioxide emissions and hence accelerate the practical application of CO2 conversion technologies.


**Keywords:** Nanocrystals, liquid-phase synthesis, molten salts, electrocatalysis, CO2 reduction, in situ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'MAchine Translation systems for the use of Hungarian and Polish Administrations' (MATCHPAD) targeting Fifth Framework.

assistant: **Abstract**

Original research objectivesThe MATCHPAD project aims at developing quality machine translation systems between Hungarian and Polish languages on the one hand, from English and to French on the other, which can be used effectively. In particular, the aim is to facilitate the communication between official bodies of the EU Member States with the administrations of these two countries, and to prepare their integration. An additional aim is to stimulate the development of commercial products that may help the industry when addressing foreign markets. MATCHPAD project intends to demonstrate and put on the market 2 new MT systems with Hungarian and Polish languages from English and to French, and so provide access for the administrations, other public bodies and private companies of Europe to information and facilitate contacts between administration, citizen and third parties. The research aspect is particularly important in this project because, if Polish language is somewhat similar to the main EU languages, Hungarian is a very different kind of language. Analysis and Synthesis of the Hungarian are quite different, due to the agglutinative structure of this language far more complicated than the languages developed in the existing MT systems. The Matchpad project is indented to develop a new family of analysis tools for the East European languages.The main tasks to be completed in cooperation between the software company and the Universities specialised in terminology research, each one in its own language, are:- Hungarian and Polish Analysis- Hungarian and Polish terminology- Hungarian and Polish Syntheses- Machine Translation Systems assembling and debugging- Software Localisation Participation of administration institutions in each country assures the high quality of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A thematic network for upgrading the built environment in europe through tensile structures'.

assistant: **Objectives**

Tensile Structures are a relatively new construction technology and have enormous potential due to their flexibility, use of minimum means and the ease with which they can be removed. However, basic and multi-disciplinary knowledge is not widespread in Europe although the design process is inevitably a knowledge-based activity. Furthermore, there are no uniform guidelines for tensile structures in Europe. This fact complicates Europe-wide activities of the industry. The Thematic Network will assemble, structure and analyse existing expertise and integrate this in knowledge bases. Specific parts of the databases such as project examples and best practice guidelines will be adapted to several end-user groups who need this information to increase the quality of the built environment. The network will identify gaps in current knowledge needing scientific research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Identification of molecular targets for the treatment of the skeletal phenotype in Lysosomal Storage Disorders' under Seventh Framework.

assistant: **Concept**

Lysosomal storage disorders (LSDs) are inherited diseases characterized by progressive intracellular accumulation of undigested macromolecules due to lysosomal dysfunction. This results in a complex phenotype with broad pathological manifestations. Most LSDs are characterized by defective skeletogenesis. Despite this, the mechanisms by which lysosomal storage affects skeletal development and function is still unknown and the efficacy of current therapies on the skeletal system is limited. This project aims at identifying the molecular mechanisms that underlye the skeletal abnormalities in LSDs and to develop novel therapeutic strategies directed toward these defects. In recent years, the lysosome has emerged as a key signaling centre, which regulates and is in turn regulated by the activity of signaling molecules. By using the Mucopolysaccharidosis VII (MPSVII) and the Multiple Sulfatase Deficiency (MSD) mouse as models of LSD, we plan to characterize the consequences of lysosomal dysfunction on major signaling pathways involved in skeletogenesis, and to identify tools and pathways that prevent accumulation and/or promote clearance of storage in bone cells. Once identified, the molecular players in these signaling pathways are appealing therapeutic targets for the treatment of the skeletal phenotype in LSD.The enhancement of lysosomal function can promote “cellular clearance” in cells affected by lysosomal storage even without correcting the underlying genetic defect. Supported by strong preliminary data, we will use genetic and pharmacological manipulation of TFEB, the master transcription factor that regulates lysosomal biogenesis, as a tool to promote clearance and in turn rescue the skeletal abnormalities of LSDs. In summary, this project aims to identify the pathog
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Development of a large scale Rapid Prototyping system for functional 3d surface Panels for automotive and industrial applications'.

assistant: **Objectives**

Many manufacturing sectors already enjoy the benefits of rapid prototyping technology. However, existing RP Systems are relatively small in scale (0.5m x 0.5m x 0.5m maximum) and rely on a layer manufacturing build style which has limitations in terms of surface finish, creating a ridged effect on some surfaces of the part. Furthermore, the resins used are not representative of production materials. Much effort is focused on making existing RP systems quicker, more accurate, or process better materials. However, no work is being done in the development of a large scale RP system for large structural 3D surface parts, i.e. body panels. Hence, in conjunction with SME rapid prototypers and potential users of prototypes in the road, rail and marine vehicle sectors, we have developed a concept for the development of a large scale RP system, that incorporates the 6 axis manipulator our company have developed. Around European 2250 SMEs are involved in OEM supply chains in the design, development and manufacture of aesthetic panels and structural components for vehicles and other industrial applications. These include pattern makers, GRP moulders, and panel manufacturers. As new panels for vehicle body panels, doors, floors and roofs are designed, a need is created to evaluate the parts for their aesthetic appeal, fit within the total assembly and even wind resistance. To enable this evaluation to occur full bodies for vehicles are often mocked up, using clay, wood , or PU foams. These models are usually constructed to assess and refine the style and form of the vehicle. However, when the engineering issues are to be evaluated prototypes for each panel section are manufactured and assembled, as hand lay up GRP panels. These prototypes are usually manufactured for OEMs by patter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of “smart” amplifiers of reactive oxygen species specific to aberrant polymorphonuclear neutrophils for treatment of inflammatory and autoimmune diseases, cancer and myeloablation.' (NeutroCure) targeting Horizon 2020.

assistant: **Abstract**

Reactive oxygen species (ROS) have key functions in healthy organism such as redox signaling for regulation of cell growth, triggering formation of neutrophil extracellular traps (NETs), and modulation of inflammation. Since in high concentration ROS are damaging to tissues, nature has evolved precise mechanisms to control their generation at the required time, concentration and space, proximal to their target. Disturbance of these mechanisms leads to aberrant ROS production that causes uncontrolled inflammation, occurs in myeloablation caused by radio- or chemotherapy and is a crucial feature of cancer cell phenotype as well as autoimmunity. Despite the damaging properties of ROS it is a paradox that pharmaceutical ROS amplifiers can reverse (“cure”) many pathologic features. For example, ROS-induced cancer cell killing inhibits cancer growth, ROS-induced deactivation of T-cells and NETs generation contributes to resolution of inflammation, and ROS-induced boosting of haematopoiesis can relieve myeloablation. These exciting possibilities have not been realized in clinical settings yet, since the high level of temporal and spatial control of ROS generation, required to allow for safe patient treatment, has yet not been achieved for any known drug. NeutroCure will be the first attempt to achieve a breakthrough solution to this problem. Using an innovative approach based on the multiple-trigger prodrug activation, this consortium will develop safe ROS amplifiers capable of boosting ROS specifically in abnormal polymorphonuclear neutrophils associated with cancer, uncontrolled inflammation and relevant for myeloablation without affecting normal cells. NeutroCure consists of 6 European academic partners and an SME who will promote commercialization of the new drugs. We expe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Self-Sustained Photonic Systems through Autonomous LOSS Harvesting' to be submitted under Horizon Europe.

assistant: **Abstract**

In the quest for efficient and sustainable technology solutions, innovative approaches to energy management are crucial. Our vision is to harness the parasitic energy (i.e., losses) of photonic integrated components and reuse it to drive the components themselves, enabling their operation with near zero external power requirements. This approach aims to revolutionize integrated photonics by drastically reducing energy consumption and enhancing sustainability.We propose collecting these energy losses using precisely designed Electro-Optical interfaces (transducers) and directing them to an integrated power management unit (PMU) that can store and release energy on demand back to the system. We plan to explore various types of harvesting interfaces, including electro-optical polymer-plasmonic joints, traditional PN junctions, and advanced approaches such as 2D materials based on graphene, as well as natural energy harvesting methods using synthetic photosystem complexes. These methods are expected to push the frontiers of interoperability between molecular physics, electronics, and integrated photonics.A key element of our vision is the creation of a photonic integrated module that is self-sustaining. This module would be part of a self-activating machine where the parasitic energy collected and managed by the PMU triggers the system and enables the module to activate. This concept has the potential to pave the way for ultra-massive integrated photonic modular networks and neuromorphic solutions, where the size of the networks can scale exponentially without a significant increase in energy requirements.


**Keywords:** Near-Zero Consumption devices, Self-Sustaining Photonic Devices, Parasitic Energy harvesting, Electro-Optical Interfaces, Integrated Photonics, Integrated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'End to end security over the internet'.

assistant: **Innovation**

The aim of this project is to contribute to the growth of the electronic commerce on Internet by developing and installing end-to-end security mechanisms for commercial transactions using the Internet infrastructure. The intention is to make a professional infrastructure that is attractive to businesses and consumers, and to support the economic growth that the Information Society offers. To fulfil this aim we propose to:- investigate secure commercial and business operations over the Internet and build the corresponding architecture models.- explore the multi-cultural and multi-country aspects of the models- implement end user and server facilities, and arrange for user evaluation at all stages- monitor and contribute to standards and market developments relevant to the field- build prototype application packages and arrange their assessment by the consortium user membersThis project will institute schemes that are appropriate to general forms of transaction, but which share core technologies that will allow businesses to use a common framework for electronic transactions of varying scales and requirements. The approach will be to make a pragmatic assessment of partner requirements, design appropriate solutions for these requirements and generalise across each set to produce the common technology framework for graceful, appropriate, large-scale electronic commerce.The general technical approach will be to establish electronic transfer schemes for a model of business being adopted by the consortium members, based on the users specifications. There are at least 5 different areas with very different requirements and the initial phase of the project will define a model which covers the key aspects of the different areas.- Retail. Random customers deal with established merc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'In Vitro and in Vivo Screens for Novel Regulators in Leukemia (NOREL)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Leukemic cells, similar to other types of cancer cells, are characterized by aberrant epigenetic changes, which often lead to abnormal expression of oncogenes and tumor suppressor genes. The goal of this project is to identify and characterize new regulators of normal and malignant hematopoiesis. We propose two complementary loss-of-function screens, using shRNA vectors against two groups of histone modifying enzymes, histone methyltransferases and histone demethylases.We plan to perform an in vitro shRNA screen, infecting mouse primary cells with lentiviruses based on single pLKO.1 vectors. We will assess the effect of down-regulation of a specific protein by flow cytometry analysis. In parallel, we will carry out an in vivo shRNA screen in a mouse model of human acute myeloid leukemia (AML). Mouse leukemic cells will be infected with a pooled retroviral shRNA library and transplanted into a small number of recipient mice. When the recipient mice develop AML, the leukemic cells will be harvested and high-throughput sequencing of shRNAs will be used to determine shRNAs depleted or enriched during initiation and progression of AML.Selected candidate genes will be validated and further characterized using in vitro and in vivo assays. Moreover, we will search for molecular mechanisms mediating the function of validated candidates in normal hematopoiesis and/or leukemia. I strongly believe that this project can lead to a discovery of novel oncogenes and/or tumor suppressors involved in AML, and potentially also to design of novel therapies for leukemia treatment.""