RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Microwave Clearance Measurement System for Low Pressure Turbines' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of this project is further development, laboratory validation, and demonstration of a microwave clearance measurement system (MCMS) on a SAGE4 GTF demonstrator engine. The system will measure radial running clearances and axial rotor displacements in the low-pressure turbine with the goal of application in a closed-loop Active Clearance Control (ACC) system. The project will first develop measurement concepts in a laboratory setting, translate these concepts to designs suitable for implementation in the demonstrator engine and then test the measurement system during an engine test. In addition, the project will demonstrate high operational reliability and field-replaceability of microwave sensors in the harsh low pressure turbine environment with the goal of at least one typical engine maintenance interval. Finally, the accuracy of the measurement of radial clearance and axial position, measurement interval, measurement signal processing and data formats will be demonstrated suitable for integration with an ACC system. Successful validation of a reliable MCMS used in conjunction with a closed-loop ACC control system for aerospace gas turbine engines will result in more efficient turbine and better engine performance and efficiency and hence improved fuel consumption and reduced emissions and will facilitate the early introduction of innovative and competitive European products into the market.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Network mOdel for MechAnism of epilepsy Dynamics' to be submitted under Horizon Europe.

assistant: **Abstract**

Epilepsy, characterized by recurrent seizures, is one of the most common neurological diseases globally affecting around 5 per 1000 people in Europe.  Yet little is known about the exact mechanism of seizure and its relationship to pathological brain structure.  From the clinical perspective, proposing the optimal surgical strategies and predicting the outcomes of surgeries are difficult due to the dynamic nature of epilepsy. The NOMAD project proposes novel network models of seizure propagation based on statistical physics, aiming at understanding the mechanism of the interplay between the brain network changes and seizure propagation, and improving the optimal surgical strategies.Numerous studies have focused on characterizing the changes in the epileptic brain network via network analysis. However, due to the bias from different measurements and the arbitrariness of choices in diverse types of network analysis, there is considerable controversy in the conclusions. Recently, spreading models built on statistical physics for seizure have been proposed which are promising in predicting epileptic surgical outcomes, yet they are inefficient in surpassing clinical criteria.Integrating recent advances in statistical physics and network science, NOMAD studies the fundamental roles of inhibitory regulations and plasticity in shaping seizure dynamics, which are neglected in previous studies. I will first study the critical dynamics of seizure on a theoretical model taking into account the role of inhibitory regulations and secondly, a computational framework considering in addition the effect of plasticity via large-scale Monte Carlo simulations. Lastly, I will apply the models to clinical data by predicting the seizure dynamics on brain networks constructed from clinical data
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Language, cognition and landscape: understanding cross-cultural and individual variation in geographical ontology' (LACOLA) under Seventh Framework.

assistant: **Objectives**

This project will break new ground in the language sciences by pursuing a linguistic inquiry into landscape. From the linguist s point of view, the geophysical environment is virtually unexplored. Yet it has vast potential for influence on the discipline. The project will play a pioneering role in situating landscape within linguistics as a fundamental domain of representational systems, opening up important links to other disciplines concerned with landscape that usually have little to do with language. It will achieve this by (1) exploring landscape categorization in a number of languages, (2) comparing such categorization, (3) developing a model for understanding categorization across languages and speakers, and (4) documenting vanishing landscape systems. The research team will study landscape categorization in six diverse language settings. Each setting is a case study carried out by a team member with expert knowledge and prior field experience of the setting. Each setting offers opportunities of studying closely related languages as well as individuals speaking the same language, making comparison possible not only among maximally diverse languages but also at finer levels of linguistic granularity. An exploratory psycholinguistic subproject will probe the relationship between language and cognition in the landscape domain. The project will blaze a trail in applying GIS to linguistic data, in testing advanced experimental techniques in the field, and in documenting domain-specific data from a global language sample. Cross-cultural variation in landscape ontology is a matter of great practical importance understanding the meaning and reference of landscape terms and place names is crucial to major fields of human cooperation, from navigation to international law.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Green Hydrogen Production and Plastic Recycling via Anion Exchange Membrane Reactors' (PHOENIX) under Horizon 2020.

assistant: **Objectives**

Achieving climate neutrality by 2050 is currently acknowledged as one the overarching objectives of the EU strategy, where smart sector integration and a just transition to a circular economy are crucial drivers.  In this respect, PHOENIX aims to develop and deliver a disruptive electrochemical reactor combining hydrogen production and plastic waste recycling. Hydrogen has manifold applications i.e., fuel, energy vector and chemical feedstock, and polymer synthesis is prevalent, 260 Mtons synthesised just in 2019 and no drastic reduction in near-term projections. Clearly, a suitable portfolio of novel and scalable technologies is urgently needed to process both commodities (hydrogen & plastics) in a sustainable way. Whence, ramping up the production of green hydrogen, i.e., renewables-derived, perfectly intertwines with the need to boost the whole volume of recycled plastic which currently amounts to only 15% of the total plastic in circulation. To this end, PHOENIX will produce an integrated power-to-molecules device by interfacing a fuel-producing/waste-recycling system to photovoltaic modules. The envisioned system will leverage an exquisite control in the assembly of modular Anion-Exchange Membrane (AEM) electrolysers, processing of nanostructured electrocatalysts and development of value-added chemical reactions to produce a scalable solar-to-chemical reactor. Finally, field validation and techno-economic assessments will identify and potentiate sector coupling along the entire energy and chemistry value chains. This project will be accomplished by an innovation-oriented small-sized enterprise, a world-class academic group and an experienced researcher, embedded in an inter-sectorial research landscape that brings lab innovation to fab delivery. Overall, the PHOENI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Network analysis of economic development and social cohesion in Europe' to be submitted under Seventh Framework.

assistant: **Abstract**

This project studies the network structure of economic development and social cohesion processes in Europe. Cutting-edge methods from network analysis and diversity measurement are used to visualise and analyse the patterns and dynamics of the economic diversification, labour mobility and innovation networks of the EU member states and accession candidates. This contributes to revealing structural convergence and divergence processes in the productive capabilities of European countries and the social choices of the people. The project provides new methods and insights, helping to:1.Advance network analysis and graphical representation techniques that allow an intuitive understanding of complex issues.2.Contribute to the MIT Macro Connections research aim to help improve our understanding of the world by putting together the pieces that scientific disciplines have helped to pull apart.3.Design industrial policies that foster qualitative diversification and economic competitiveness in EU member states and accession candidates.4.Create social cohesion policies that take systemic inequality reproduction into account and foster the agency of the people.5.Foster the Turkey - Germany - EU - relations.The project highlights that realising smart, sustainable and inclusive growth requires positive internal and external cooperation patterns, as well as the recognition and promotion of diversity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced Innovation Support Services for SMEs' under Horizon 2020.

assistant: **Concept**

The AISS4SME project aims at offering new services to enhance the innovation management capacities of luxembourgSMEs. 2 target group of SMEs will be address : first, the beneficiaries of the SME instrument and, second, innovative SMEs.This proposal is a response to the Consultation of Enterprise Europe Network partners on the work programme for2019 H-2020 activities H2020-EEN-SGA3-2019 “Enhancing the innovation management capacity of SMEs” inthe Enterprise Europe Network”, and concerns the set up of coaching and mentoring services for SMEs. It’s our confidence that the AISS4SME proposal is 100% in line with the challenge and scope defined by the EC. Moreover, by pursuing the defined strategic objectives, the project will automatically produce the expected overall impact of: • Enhancing the commercial potential and impact of SME participation in the dedicated Horizon 2020 instrument by ensuring that the project is aligned with and developed as an integral part of the company's innovation strategy, • Achieving tangible organizational change and improved results, • Improving the skill's levels of managers, leaving a legacy such that the SME is better able to overcome the barriers to growth post-Horizon 2020 participation.


**Keywords:** Innovation, Advisory, Key Account Management, KAM, H2020, Fast Track to Innovation, Future Emerging Technologies, Innovation Management Capacity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a Sustainable Bio-Organocatalytic Cascade for Stereoselective Amide Synthesis in Pharmaceutical Applications' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Amide bond formation is fundamental to the synthesis of a wide array of amide-containing drugs. Conventional methods for amide synthesis typically rely on stoichiometric activating agents that are harmful to the environment and less sustainable. Therefore, there is an urgent need for more efficient, selective, and sustainable methods for amide synthesis. This project addresses these challenges by designing a novel bio-organocatalytic cascade reaction for the stereoselective synthesis of amides, including chiral amides, by integrating biocatalytic and organocatalytic strategies.The proposed method exploits the high chemo- and stereoselectivity of ω-transaminases (ω-TAs) for the synthesis of chiral amines from carbonyl compounds, in conjunction with a newly developed direct amidation method using choline chloride (ChCl) as a green catalyst. This project will thus deliver an innovative platform for the direct transformation of carbonyl compounds into amides in a one-pot process. Adhering to green chemistry principles, the method eliminates the need for hazardous reagents and solvents, while employing mild reaction conditions and renewable catalytic systems. Additionally, microwave-assisted heating is utilized to accelerate the reaction rate, enhance yields, and reduce energy consumption. The bio-organocatalytic cascade will significantly reduce the number of steps, reaction time, and resource consumption compared to traditional methods. It will also be scaled up to demonstrate potential for industrial applications.In summary, this interdisciplinary project combines expertise in biocatalysis, organocatalysis, microwave-assisted synthesis, and analytical chemistry to deliver a viable solution for sustainable amide synthesis, which is critical in pharmaceutical manufacturing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Reconstructing Roman Road Network for the understanding of Urban development' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The Roman conquest, occupation and dominion over a large part of current Europe and beyond marked a strong change in social, cultural and economic patterns in the area. Two of the most important and lasting changes were the establishment of a new transport network and the large-scale development of cities. Connectivity continues to be seen as an essential factor in the analysis of the spread of urbanisation, migration, the ancient economy, and the transmission of ideas. In Antiquity connectivity could only be achieved via movement by land, river and sea, and had to rely on the available transport network. However, to date, no analysis of communication, trade, distribution of people and resources, or the economy in general, exists that actively considers the transport network, the single element that made connectivity possible, on an Empire-wide scale and therefore no attempts have been made to understand its influence on urbanism or its long-term influence. This is largely due to the lack of complete reconstructions of Roman route systems. Although much is known about the roads and other elements of the Roman transport network, this knowledge is partial and lacks integration. The road transport network is full of empty spaces and broken links that prevent the development of an integrated system fit for large-scale analyses and the use of quantitative and computational approaches.R3NUrb will address these problems by reconstructing the whole Roman transport network and using it to analyse the influence of  connectivity on the process of urbanisation, urban distribution and the long term success of urban centres. For this R3NUrb will employ an innovative combination of computational approaches, remote sensing, network science, and geostatistics. This approach will provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'An experimentally-validated multi-scale materials, process and device modeling & design platform enabling non-expert access to open innovation in the organic and large area electronics industry', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

MUSICODE is an ambitious project which addresses the H2020 Call DT-NMBP-11-2020 “Open Innovation Platform for Materials Modelling” that will develop a novel Open Innovation Materials Modelling Platform to enable the Organic and Large Area Electronics Industry (OLAE) to expediate accurate and knowledgeable business decisions on materials design and processing for optimization of the efficiency and quality of OLAE device manufacture. This platform will integrate: (a) Material, process and device modelling with workflows spanning the micro-, meso- and macro- scales, validated by expert academic and industry partners. (b) Integrated data management and modelling framework with ontology-based semantic interoperability between scales, solvers, data and workflows, with industry-accepted material and process modelling parameters and protocols, employing graphical user interface tools for workflow design, analysis, optimization and decision making. (c) Plug-ins to Materials Modelling Marketplaces, Open Translation Environment, Business Decision Support Systems, etc. and to High Performance Computing infrastructures for workflow execution. The platform will demonstrate industry user case workflows to optimize OLAE materials selection & design as well as printing and gas-phase manufacturing. The MUSICODE Business Plan will ensure the platform sustainability, exploitation and industrial adoption beyond the project, with the ambition to become the central Open Innovation Hub for the OLAE industry and evolve as the central paradigm for cross-domain applications.


**Keywords:** organic electronics, multiscale materials modelling and validation, manufacturing process modelling, interoperability, ontology, database, open innovation platform, integrated modelling framework
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Generation of Novel Cardiotropic AAV-Based Serotypes to Evade Human Humoral Immunity' under Seventh Framework.

assistant: **Concept**

Cardiovascular diseases remain the primary cause of morbidity and mortality in the western countries. Pharmacological treatment improves survival and quality of life, but does not reverse disease progression. Gene therapy could fill this void, owing to its ability to treat the underlying cause. Adeno-associated viruses (AAV) emanated in the past decade as potent vectors, owing to their tropism for specific tissues, their low immunogenicity, their lack of pathogenicity and their ability to sustain long-term expression. As a testament to their potential, the European Commission approved the first gene therapy (Glybera) and several cardiac gene therapy clinical trials, one phase IIb, are underway using AAVs for gene targeting. Despite their growing success, a major impediment is the presence of pre-existing antibodies in patient serum, which excludes almost 50% of the population from clinical trials. The currently prominent approach, generation of novel serotypes from the known cardiotropic ones (AAV6 and 9) by random mutagenesis, alters favorable serotype attributes and most importantly tropism.Our goal is to generate novel serotypes based on AAV6 and 9, using a directed mutagenesis approach, against only the amino acids involved in neutralization but not receptor binding and therefore tropism. The mutant AAVs will be tested in vitro and in vivo for neutralization, transduction efficiency and cardiac tropism. Alternatively, a semi-random mutagenesis library approach focusing on 3-5 key amino acids will be pursued.Overall, the proposed study, using standard molecular biology techniques, will produce an immunogenic map of the cardiotropic AAVs, generate a panel of novel AAVs that evade humoral immunity but retain tropism, and therefore unequivocally provide with most needed