RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Bacterial Methionine Oxidation Repair and Aging'.

assistant: **Innovation**

Identifying the causal molecular processes of aging is a long-standing quest in biology. Oxidative stress is a conserved hallmark of senescence among living organisms, but the underlying mechanisms linking oxidative damage and aging have proved difficult to unravel. Multiple reports pinpoint Methionine oxidation as an important antioxidant system influencing the lifespan of cells. Here, I propose to develop an approach including single-particle tracking and microfludic-based single-cell imaging to visualise Methionine oxidation repair in live E. coli bacteria. Such method is currently lacking in the field and its development, although challenging, could deepen our understanding of how system-level failures emerge out of molecular damage.


**Keywords:** Bacteria, Methionine, Sulfoxide, Msr, Single-molecule imaging, Microfluidic-based microscopy, Aging, Live single-cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Work stress, well-being, and intention to leave the profession: comparison between European and Chinese nurses'.

assistant: **Concept**

The nurse shortage is an international issue. In USA more than one million new nurses will be needed by the year 2010; and most European countries are in need for large quantity of nurses, too. However, the nurse shortage happens not only in developed countries, but also in developing countries, such as in China. According to the World Health Report 2006 – WHO, the density of nurses per 1000 in China was only 1.06 (ranking 133 out of 191 countries) while the average was 4.06 in the world. In addition, the international East-West migration of nurses makes the situation worse in the less developed and developing countries. On the other hand, the premature departure increases the loss of nursing staff. What makes the nurses want to leave their profession?  The EU-funded NEXT (nurses' early exit) -Study is investigating the reasons, circumstances and consequences surrounding premature departure from the nursing profession, which has been conducted in 11 European countries in recent years. The findings indicate that stressful psychosocial work characteristics and health reasons are the main causes of premature departure in nurses. Since 2006, a research team from China has collaborated with the European NEXT-Study group to examine the association among work stress, well-being, and intention to leave the profession in Chinese nurses. It is of interest to apply the well-established theories and knowledge from Europe into China in the research field of nursing science, occupational health psychology, medical sociology, and epidemiology. This proposed research is the NEXT follow up project to compare the data between European and Chinese nurses. The comparison would be helpful for the exploring the divergence and concordance of professional withdrawal behaviour in different popu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Investigating the role of food structure and processing in lipid digestion for production of healthier food' (2007-2013) under Seventh Framework.

assistant: **Objectives**

FoodPro ForHealth will develop rational strategies to formulate and process foods to control lipid digestion, and combines the Fellow’s food science skills with expertise and techniques at the Institute of Food Research (IFR) in the colloids, interfacial, model gut and health areas.Obesity is a major health problem in Europe/developed countries and a risk factor for chronic diseases (diabetes and cardiovascular disease, CVD) leading to anti-obesity campaigns promoting healthy eating and a healthy lifestyle. Lipids are the most energy dense of macronutrients and excess consumption has been linked to obesity. Most people find it difficult to change their diets to eat healthily. Changes in food manufacturing are needed to develop healthier products and ingredients. Lipids are water insoluble and their breakdown in the digestive tract occurs at the fat/water interface so the composition at the fat interface can affect lipid digestion in vitro. If lipid digestion is controlled, energy release during digestion is prolonged and hyperlipidaemia, a CVD risk factor, reduced. Slowly-digested lipids can also increase satiety, control energy intake and help manage weight loss. State-of-the-art physicochemical techniques will be used to study how common food structures in emulsified foods influence the breakdown/digestion of lipids in vitro. The interaction of these structures with digestive enzymes, surfactants and lipids will be studied in the gastric and duodenal environment. Better understanding the factors affecting the nature/extent of lipid breakdown in model systems and real food models will allow science-based strategies to modify food products or develop new products to optimise fat digestion. The project will assist the Fellow to develop new research projects on her return
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optogenetic Analysis of Serotonin Function in the Mammalian Brain', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Serotonin (5-HT) is implicated in a wide spectrum of brain functions and disorders. However, its functions remain controversial and enigmatic. We suggest that past work on the 5-HT system have been significantly hampered by technical limitations in the selectivity and temporal resolution of the conventional pharmacological and electrophysiological methods that have been applied. We therefore propose to apply novel optogenetic methods that will allow us to overcome these limitations and thereby gain new insight into the biological functions of this important molecule. In preliminary studies, we have demonstrated that we can deliver exogenous proteins specifically to 5-HT neurons using viral vectors. Our objectives are to (1) record, (2) stimulate and (3) silence the activity of 5-HT neurons with high molecular selectivity and temporal precision by using genetically-encoded sensors, activators and inhibitors of neural function. These tools will allow us to monitor and control the 5-HT system in real-time in freely-behaving animals and thereby to establish causal links between information processing in 5-HT neurons and specific behaviors. In combination with quantitative behavioral assays, we will use this approach to define the role of 5-HT in sensory, motor and cognitive functions. The significance of the work is three-fold. First, we will establish a new arsenal of tools for probing the physiological and behavioral functions of 5-HT neurons. Second, we will make definitive tests of major hypotheses of 5-HT function. Third, we will have possible therapeutic applications. In this way, the proposed work has the potential for a major impact in research on the role of 5-HT in brain function and dysfunction.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Changing Inequality at Educational Transitions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

EDUCHANGE aims to become one of the first ever projects to conduct simultaneous field experiments in four strategically selected countries (Denmark, Germany, Hungary, Iceland) with the goal to reduce inequality at the educational transition from compulsory to secondary education and at the transition to higher education. While experimental intervention studies have become more common in sociology and economics in recent years, EDUCHANGE will address five critical limitations in this literature: 1) No information or career guidance experiment with the goal to reduce inequality at educational transitions has ever been implemented in different countries with a harmonized design. This is puzzling given the importance of institutional context for the generation of inequalities in education 2) The majority of experiments focus on the transition to higher education while neglecting earlier transitions which are particularly relevant in tracked European education systems 3) Previous experiments have hardly considered the role and knowledge of professional counsellors 4) Previous interventions have mainly focused on updating students’ biased perceptions of costs and returns while neglecting other psychological and social barriers 5) Advances in multimedia technologies have only to a limited extent been integrated in previous experiments.Key outcomes of EDUCHANGE will include: (a) A more nuanced conceptual understanding of how career guidance and information provision can help to reduce inequalities (b) A comparative study of students’ subjective evaluation of costs, returns and probabilities of success and psychological barriers they attach to different educational alternatives in a comparative perspective (c) Knowledge about to what degree institutional context has an impact on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ocean Energy ERA-NET Cofund' (2014-2020).

assistant: **Concept**

AbstractOCEANERA-NET COFUND aims at coordinating the efforts of 8 agencies, in 4 Member states and 4 regions, in the ocean energy area. The joint action will focus on the demonstration and validation of innovative technologies for the generation of electricity from waves, tidal current, tidal range, salinity gradient and ocean thermal energy conversion, which will lead to improved performance, reliability and survivability of ocean energy conversion devices and arrays, and reduction in the levelised cost of energy (LCOE).   The project will comprise:• A Co-funded Joint Call to support transnational, collaborative demonstration projects• A second joint call to support transnational, collaborative research, development, demonstration and innovation  projects• Joint activities to improve coordination between national / regional research programmes, coordinate with key stakeholders and promote knowledge transfer and exploitation of resultsThe project aims to build on European industrial leadership to help create a new industrial sector, which has potential to make a significant contribution to the decarbonisation of Europe’s energy system, economic growth, job creation, particularly in peripheral regions.The consortium represents the leading countries and regions in the European ocean energy sector – Scotland (UK), Sweden, Spain, Basque Country (Spain), Ireland, Portugal and Bretagne and Pays de la Loire (France).


**Keywords:** Ocean Energy Wave Tidal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Benchmarking and foresight for regions of Europe'.

assistant: **Innovation**

The project proposes to perform the comparative analysis (benchmarking) of efficient support instruments for the RTD in geographical areas with demographic significant imbalances. In this way also specific tools of support would be analyzed to the companies / entrepreneurs of the rural way. Also, there would develop a panel of indicators of impact of the regional policies of support to the RTD in this type of regions.The regional organizations in this project, which provide high degree of input in their corresponding regional RTD policy-making, include regions in Spain (Castilla y Leon), Sweden (Mid Sweden), Germany (Brandenburg), Romania (West Romania) and Estonia (Tartu and South Estonia) thus covering territories with different idiosyncrasies and entrepreneurial characteristics within the European frame, which will enrich the benchmarking process. A special attention will be paid to the case of regions that have obtained significant advances implementing RTD policies in the last years (For example: Regions to which the good use of the resources has allowed, or will allow, to leave the Objective 1). In the consortium there take part several regions of this type (Castilla y Leon, Brandenburg).These regions will carry out a task of mentoring on the rest of regions in the project. Other objective of the project is to carry out prospective studies of policies / support instruments to RTD guided to future sectors, intensive in knowledge and with added high value: Aeronautical, transport, biotechnology, ICT and clean and/or renewable energies. The development of these sectors will allow to the participant regions to maintain and promote equilibrium between the competitiveness of its basic industries and businesses and the bid to introduce new economic activities in sectors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Fairness and Explanations in Group Recommender Systems. Towards Trustworthiness and transparency' to be submitted under Horizon Europe.

assistant: **Abstract**

Today, most social media networks use automated tools to recommend content or products and to rank, curate and moderate posts. Recommender systems (RSs), and in particular Group recommender systems (GRSs), -a specific kind of RSs used to recommend items to a group of users-, are likely to become more ubiquitous, with expected market forecast to reach USD 16.13 billion by 2026.These automated content governance tools are receiving emerging interest as both algorithms and decision-making processes behind the platforms are not sufficiently transparent, with a negative impact on domains such as fair job opportunities, fair e-commerce or news exposure.Two of the key requirements that have to be fulfilled to build and keep users’ trust in AI systems while guaranteeing transparency are Fairness and Explainability. But, aside from some previous attempts to enhance both aspects in traditional-individual RS, they have hardly been explored in GRSs. FIDELITY addresses this challenge by developing novel algorithms and computational tools in GRS to boost explanation, fairness, and synergy between them through a disruptive multidisciplinary research approach that: 1) extensively brings SHAP and LIME, as state-of-the-art post-hoc explanation approaches in AI, into RS and GRS contexts, 2) bridges explanation and fairness in RS and GRS, introducing an explanation paradigm shift moving from “why are the recommendations generated?” to “how fair are the generated recommendations?” and, 3) transversally evaluates the new methods through real-world GRSs and user studies. The ultimate goal is to guarantee greater user trust, and independence of RS output from any of the sociodemographic characteristics of users. The training programme, designed with the aim to fill the existing gaps between co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The role of nervous system in progression of breast cancer: focusing on neuropeptides released from sensory neurons and inflammatory mediators' to be submitted under Sixth Framework.

assistant: **Abstract**

Breast cancer is the leading cause dead in women. Mortality arises from distant metastases. Hence it is crucial to reveal host and tumour derived factors responsible from metastasis. Recently I have found that sensory neurons sensitive to capsaicin are important in cancer progression. Specifically, inactivation of sensory neurons with capsaicin increased lung metastases significantly.This is probably due to both altered tumour microenvironment and systemic response to tumour. Sensory nerves contain vasoactive peptides such as Substance P (SP) and Vasoactive Intestinal Peptide (VIP). In order to understand the mechanisms, I have screened expression of 12000 genes in primary breast carcinomas (4T1 cell line) from control and capsaicin treated animals (Balb-c mice). I found that inactivation of sensory neurons allows growth of cancer cells with higher metastatic potential and that decreased expression of peptidases and substance P fragments may increase breast cancer metastases (manuscript in preparation).Definitive proofs however are missing. Hence my first goal is to clarify the role of neuropeptides and their physiological fragments in breast cancer progression. Specifically I will treat the balb-c mice injected with 4T1 cells with SP fragments that were identified in my previous work and will determine their possible anti-tumour effects. Sensory neuromediators regulates immune system, such that while some induces inflammatory response, others stimulate anti-inflammatory pathways. Chronic inflammation is a significant risk factor for development of malignancy. Since inactivation of sensory neurons enhanced the metastases, it is likely that uncontrolled inflammation occurred following inactivation. To clarify this point inflammatory and anti-inflammatory cytokines as wel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Supporting task-level reasoning in simulation-based interactive learning environments', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Research objectives and content systems with potential suitability for magneto-optic (MO) data storage. The class of materials chosen are orthoferrites which exhibit high coercive fields and low saturation magnetisation. A high coercive field and substantial Faraday rotation of polarised light are essential for good MO data storage. The main aim is to produce orthoferrite films using pulsed laser deposition, studying the magnetic and magneto-optic properties. Of particular interest will be the dependence of growth conditions on the coercive field, saturation magnetisation and the orientation of the magnetic moments with respect to the sample plane and crystalline axes. Depositing a soft magnetic layer (spinel) adjacent to the hard magnetic layer (orthoferrite) should give rise to a range of possible magnetic couplings between the layers, through an intervening oxide layer, allowing an engineering of the global magnetic properties of the whole sample in order to combine high saturation magnetisation with high coercive fields.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exposure to micro-organisms and suppression of allergic diseases: A European research training scheme' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Allergic disorders are increasing rapidly within the European Union. European groups led the discovery that diminishing exposure to microorganisms is a factor in this increase. European groups were also the first to demonstrate the presence within helminths and saprophytic mycobacteria of components that drive the formation of regulatory T cells in vitro and in vivo. This is now accepted as the explanation for the ability of exposure to these organisms to protect from allergies. The importance of this mechanism and its potential exploitation to discover new treatments for allergic disorders have resulted in its inclusion as an area of activity within GA2LEN (Global Allergy and Asthma European Network of Excellence).GALTRAIN will:1) expand the number of groups involved;2) extend the epidemiology into an immunogenetic understanding of individual susceptibility to this type of disordered immunoregulation;3) expand the range of microorganisms known to be involved in immunoregulation;4) identify the active molecular components, their structures and their modes of action;5) take steps towards their exploitation as novel pharmaceutical agents.GALTRAIN members have links with industry and will work with biotech companies to facilitate eventual commercial exploitation within the EU. Most GALTRAIN fellows will register for a PhD within the institute of a GALTRAIN partner, and then, following creation of a detailed plan of training units, spend periods within the laboratories of other partners. Although the Bologna Treatment" has not yet led to the creation of a EuroPhD, GALTRAIN members have negotiated mechanisms within their own institutions to permit the pioneering of this crucial step towards integration of European science and creation of critical mass that can compete with t