RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated Activities for the High Energy Astrophysics Domain' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

We propose a set of integrated Activities in the High Energy Astrophysics Domain (AHEAD) in response to the INFRAIA-2014-2015 call Research Infrastructures for High EnergyAstrophysics.The overall objective of AHEAD is to integrate national efforts in high-energy Astrophysics and to promote the domain at the European level, to keep its community at the cutting edge of science and technology in this competitive research area and ensure that space observatories for high-energy astrophysics are at the state of the art. AHEAD will integrate key research infrastructures for on-ground test and calibration ofspace-based sensors and electronics and promote their coordinated use. In parallel, the best facilities for data analysis of high-energy astrophysical observatories will be made available to the European community. The technological development will focus on the improvement of selected critical technologies, background modeling, cross calibration, and feasibility studies of space-based instrumentation for the benefit of future X-ray and gamma-ray missions, and the best exploitation of existing observatories.  AHEAD will support the community via grants for collaborative studies, dissemination of results, and promotion of workshops. A strong public outreach package will ensure that the domain is well publicized at national, European and International level. The virtual circle infrastructure - networking - joint research activities, as devised in AHEAD, serves to establish strong connections between institutes and industry to create the basis for a more rapid advancement of high-energy astrophysical science, space-oriented instrumentation and cutting-edge sensor technology in Europe. This enables the development of new technologies and the associated growth of the European te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Decoding of invisible laser markings for theft protection' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The frequency of e.g. cars thefts, which has risen drastically since the nineties, calls for the European SMEs to undertake European and international measurement for protection and long-term reduction and avoidance of thefts. The aim of the project is the development of a procedure for the visualisation of a painted and by that concealed, invisible laser beam inscription using the so-called heat impulse thermography. Painted sheets, which are used for car body components can be codified by a laser beam inscription, which by painting, can be concealed, and thus be made invisible to the human eyes. Car body components which are treated in this way can at any time be decoded by thermographic methods, and so be identified. Ranges of application of this new technique areas for example, border controls for fighting car thefts. At any given place of the car body, laser beam codification can be concealed during production. A border control would be able to identify, fast and definitely, a stolen automobile, despite altered car documents or altered chassis type identification number. The codification would be linked inseparably with the vehicle, and could only be removed by a large-scale exchange of components (e.g. roof, bars etc.). A secure and reliable possibility for border control of car thefts could thus be created.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Optimisation of Integrated Solid Waste Management Strategies for the Maximisation of Resource Efficiency' (WASTECOSMART).

assistant: **Concept**

WASTECOSMART - Optimisation of Integrated Solid Waste Management Strategies for the Maximisation of Resource Efficiency addresses the priority areas of a “Resource Efficient Europe” and relates to the EcoAP, by boosting innovation based on research and technology development within the field of integrated waste management. Through cross border cooperation and collaborative research activities between six regional research driven clusters, the project will strengthen regional capacities for investment, research and technological development. The core goal is to help introduce innovation to the market in this sector and as a consequence support economic growth and regional development. The partners of WASTECOSMART will join forces to elaborate one Joint Action Plan (JAP) for the coordination and strengthening of their complementary RTD capacities. In close consultation with regional stakeholders from the scientific world, businesses and public authorities (triple helix), the regions will elaborate a coordinated set of Regional Research Agendas and a cross-regional Joint Action Plan, which sets a common roadmap for future collaborative RTD activities and develops synergetic follow-up projects in these key domains. The formation of regional waste management clusters is further strengthened through the mentoring of less developed regions, the dissemination of the outcomes on various platforms and internationalisation measures reaching out to other high potential regions in the world. WASTECOSMART’s approach to waste management will be based on a novel and innovative process applying a holistic set of practices. So far, there are very few studies that employ the methodological concept of innovation systems analysis, and only a few studies dealing with anything other than isol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Back for the Future' under Horizon 2020.

assistant: **Concept**

The project Back for the Future (Back4Future) intends to upgrade the currently existing Central European Institute of Technology (CEITEC) seated in Brno, Czech Republic, and bring it up to the level of a true Centre of Excellence in the fields of Advanced Materials and Nanotechnologies. The addressed research area is in a direct link with the recent EU initiatives, namely the Key Enabling Technologies. This should be done by implementation of a “break-through” strategy based on expertise and direct collaboration with external top-performance institutes. In this respect the project benefits from the geographic, historical and cultural proximity of Vienna and its renowned two universities: Vienna University of Technology (TUW) and University of Natural Resources and Life Sciences (BOKU) which are members of the project consortium. They act in the project as the leading universities in technical and life sciences, respectively, towards the CEITEC partner institutions. In this way a unique CEITEC combination of advanced materials and technologies with life sciences is fully matched and provides optimal conditions for multi- and cross-disciplinary cooperation in the consortium. This should lead to increasing scientific capabilities, improving of innovation performance and maximizing chances to obtain competitive funding. Moreover, the innovation culture should be boosted in general, utilized in more intensive cooperation with high-tech companies and spread to substantially increased number of start-up companies in the South Moravia and nearby regions. We envisage extending these activities beyond the end of the Back4Future project and to the wider region, including Bratislava, Wroclaw and, possibly, Budapest, Linz, Graz and Prague.


**Keywords:** Key enabling technologies,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A secure, modular and distributed mobile border control solution for European land border crossing points' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

MobilePass will focus on research and development towards technologically advanced mobile equipment at land border crossing points. This will allow border control authorities to check European, visa-holding and frequent third country travellers in a comfortable, fast and secure way. The mobile solution incorporates new technologies needed in mobile scenarios and embeds them in the actual border crossing workflow to speed up control procedures.MobilePass brings together system- and component producers, research institutions and governmental authorities. The entire innovation process, from development to integration, will continuously be evaluated by border guard authorities.Promoting both security and mobility within the EU Border control is a major challenge for member states border control authorities. Travellers request a minimum delay and a convenient, non-intrusive border crossing, while border guards must fulfil their obligation to secure the EUs borders against illegal immigration, terrorisms, crime and other threats.The MobilePass development process addresses both requirements with equal emphasis, keep security at the highest level while increasing the speed and the comfort for all legitimate travellers. Aspects of a fast border crossing by legitimate travellers are a (i) reliable and convenient capture of biometric and passport data, (ii) dependable, secure wireless data transfer, (iii) and a modular mobile equipment optimized to the border control workflow. Improved traveller identification technologies, such as contactless fingerprint capture and advanced mobile facial capture will increase the security, minimise spoofing and evasion, while making the control less cumbersome for passengers.A system evaluation and demonstration will be done in two different me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Personalized oncology for refractory and relapsed lymphoma using humanized patient derived othotopic xenografts (ImmunePDOX)' to be submitted under Horizon 2020.

assistant: **Abstract**

This proposal is a “PORTAL” to re-incorporate Dr. Lourdes Farre from the Oswaldo Cruz Foundation (FIOCRUZ) in Brazil to Europe at the Catalan Institute of Oncology (ICO), a part of the Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. She will be supervised by Dr. Alberto Villanueva, leader of the Resistance, Chemotherapy and Orthotopic Xenograft Models Group and Director Board of the EuroPDX (www.europdx.eu) in collaboration with Dr. Ana Sureda, Head of the Hematology Department (ICO). Dr. Farre worked at FIOCRUZ for 12 years where she relevantly contributed in lymphoma research and acquired maturity as an independent researcher. Dr. Farre will contribute to ICO/IDIBELL initiating a new research line in resistance in hematological cancers and transfer her knowledge in HTLV-1 infection. She will also contribute to the ICO Hematology Service with a personalized oncology strategy for clinical oncology practice. Knowledge and preclinical models could be transfer to the IDIBELL`s spin-off Xenopat and Pharmaceuticals. She will have access to a solid multidisciplinary training program that will provide qualitative improvement on her career and a privileged position to be reintegrated in a long term research position in Europe. She has always combined scientific activity with educational interventions. Besides scientific dissemination, she programmed public engagement activities. This proposal is a proof-of-concept of personalized oncology for refractory/relapsed lymphoma and aims to study the mechanisms involved in response to therapy using preclinical humanized orthotopic models. Relapsed/refractory lymphomas represent a major treatment challenge and general treatment paradigm has remained empiric. Defining the best therapeutic option for each patient and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'First Chemoselective Synthesis and Structural Studies of Lasso Peptides' (FCSSSLP).

assistant: **Concept**

The main objective of this project is to promote the use of peptides as potential therapeutic agents. We now know that ribosomal peptides, and specifically lasso peptides, which are biosynthesized by bacteria as agents of defense, show a compact and rigid structure, giving a high stability against physical, chemical and proteolytic degradation. The spectrum of biological activities of these peptides is very wide, acting as antibiotics and also as enzymatic inhibitors, such as the case of the HIV virus protease. Thus, they show a great potential as a therapeutic alternative to existing drugs. To achieve this goal, the project is divided into two distinct parts, to be performed in the two chosen sites, strategically combining the synthetic aspects (TSRI, San Diego) with the structural determination and their involvement in recognition molecular processes (CIB-CSIC, Madrid) .Firstly, synthetic efforts will be made to chemically synthesize the lasso microcin J25 (MccJ25).  It will be an extraordinary example of how we, chemists, can use very complex chemoselective reactions, which are usually reserved for biosynthetic enzymes.  During the second part of the project, the first structural studies of Lasso peptides-protein complexes will be accomplished using the synergy of combining NMR with computation methods.The selected research centers to achieve this project are: The Scripps Research Institute (TSRI), being the project supervisor Prof. Phil Baran and Centro de Investigaciones Biológicas (CIB-CSIC), with Prof. Jesús Jiménez-Barbero. Both research groups and centers have a well-gained international prestige.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Inherited disfunctions of brain microcirculation' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cerebral cavernous malformations (CCM) is a disease characterized by focal capillary-venous cavernomas located in the central nervous system. These malformations are fragile and bleed leading to seizures, paralysis and cerebral hemorrhages. The familial form of CCM is due to loss of function mutations of anyone of three genes called Ccm1, Ccm 2 and Ccm 3. Open skull surgery is the only possible therapy since effective medical treatments are still missing. In mouse models of CCM and human patients’ specimens, endothelial cells (ECs) lining the cavernomas co-express endothelial, mesenchymal and stem cell markers. These features combined to high cell proliferation are reminiscent of tumor initiating cells. In preliminary work, we isolated a rare population of highly proliferative ECs (V-EPC) intermingled with the normal vascular endothelium in vivo and co-expressing endothelial and stem cell markers. Our working hypothesis is that CCM originates from the clonal expansion of these V-EPCs that are more sensitive than mature endothelium to inactivation of Ccm genes. This possibility is supported by the observation that V-EPCs present a comparable gene expression profile and selective markers than the ECs lining CCM cavernomas. The project is divided in three related objectives: 1) To define the nature and functions of V-EPCs in normal vessels; 2) to test the capacity of V-EPCs to trigger the formation of CCM by undergoing clonal expansion in vivo; 3) to test whether targeting V-EPCs or inducing V-EPC maturation by pharmacological tools reduce or prevent the formation of CCM. If successful this work will introduce novel concepts in vascular biology such as: 1) the presence of resident V-EPCs that are differentially sensitive than mature endothelium to the same genetic mutation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of a low-cost permanently installed microelectronic wireless monitoring system for process plant (SENS-IT)' (SENS-IT).

assistant: **Concept**

The prime industry goal is to achieve zero loss of containment in a process plant. The Sens-IT proposal is focused on non-intrusive, low-cost, global, and rapid Screening techniques based on Permanently Installed Monitoring (PIM). This will enable real-time, on-line monitoring and assessment of large areas of pant, with the objective of eliminating loss of containment and drastically reducing downtime attributable to existing inspection and monosophies. The key issues surrounding the technology are the ability to sense defects, process information, and transmit this data via wireless methods to the plant operator, such that the operator can monitor and react to issues of plant integrity. Technology advances in new materials, new sensing techniques, microelectronics, data processing, and use of wireless communication methods is the basis of development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Recentering Friction Floor Dissipater for Resilient-based Design of Steel Structures' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In regions of moderate and high seismicity such as Europe, steel concentrically braced frames (CBFs) are considered a cost-effective lateral force resisting system to withstand seismic and/or wind loading. Comprehensive building-specific economic loss assessment suggests that the expected annual losses of steel CBF buildings are mainly associated with repairs of acceleration-sensitive building components, which in turn results into building functionality disruption after an earthquake. Higher building vibration mode effects and the complex asymmetric inelastic behaviour of steel braces make it challenging to prevent soft-storey mechanisms that potentially lead to global collapse even in capacity-designed steel CBF buildings. The proposed project aims to address the aforementioned issues by developing an innovative dissipation device, named Recentring Friction Floor Dissipator (RFFD) to control the earthquake-induced vibration and demands in steel CBF buildings through its diaphragm response instead of the lateral load resisting system that is traditionally attempted. This will minimize the variability of the inertia force demands along with the earthquake-induced life-cycle costs. The device realization will be achieved through physics-based computational simulation-based design validated to full-scale testing. Macro-models will be developed to facilitate, for the first time, time-dependent nonlinear building simulations that will be benchmarked to a landmark system-level experiment. A graphics-based design tool will be developed that will combine in a single format economic loss metrics with multiple building performance indicators to aid decision-making for enhanced building service life in seismic regions.After having acquired extended experience in the field of eart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Ion Spectroscopy of Reaction Intermediates'.

assistant: **Concept**

Modern chemistry experiences a fast development of new reactions with dominance in organometallics and recently also organocatalysis. The massive synthetic progress however greatly foreruns mechanistic studies and the deeper insight is often rather limited. This large unexplored area accordingly challenges pioneering research and formulation of new concepts in chemistry. The present research project uses the most powerful tools of several research disciplines and aims towards the investigation of the elementary steps in organic reactions by means of mass spectrometry (MS) in combination with electrospray ionization (ESI) and quantum chemistry with a particular focus on ion spectroscopy.The research will concentrate on elementary reactions in catalysis, e.g. the interaction of catalysts with substrates or bimolecular reactions of reactant/catalyst complexes. A major innovative contribution consists in applying ion spectroscopy for the structural characterization of reaction intermediates using a newly proposed tandem mass spectrometer with a cooled linear ion trap, which will allow two-photon experiments with IR and UV tunable lasers. The experiments will provide specific information about various intermediates and will help to disentangle even complicated mixtures or isomeric ions. In addition, an innovative experiment is designed, in which bimolecular reactivity of isobaric ions will be studied individually. Kinetics of selected reactions in solution will also be followed by ESI/MS. The combined efforts of these different approaches will provide a comprehensive understanding of the reaction mechanisms and will lead to the formulation of new general concepts in organic and organometallic reactivity.