RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Gallium-arsenide with Orientation-patterning for All-optical non-Linear Signal-processing'.

assistant: **Concept**

Innovative tailoring of non-linear optical properties of GaAs wafers, used to manufacture guided-wave photonic functional components, is a key to competitive high-speed wavelength management in the telecommunication region. Targeting breakthroughs in terms of conversion efficiency and versatility, this project will explore a novel processing concept and carry out quantitative assessment of key parameters in order to weight the risk against prospects for a large scope of applications. At a time when the part of ultra fast modules relying on optical functions keeps increasing, GOALS concept opens on very rich semiconductor research: in the long term, it will enable monolithic integration of pump diodes with the above wave guide devices, turning them into broadband multi-functional all-optical data processing chips.OBJECTIVESThe GOALS consortium wants to promote the use of the high intrinsic quadratic no linearity of widely used semiconductor materials as a competitive solution to manufacture a large scope of ultra fast all-optical data processing devices. The corresponding switching, WDM-oriented frequency conversion, and regeneration functions will render practical future high capacity telecommunication networks needed to implement a user-friendly information society. The basic technique involves wave mixing in wave guides engineered with the proper spatial modulation of their non-linear optical properties, according to the laws of quasi-phase matching. The project aims at assessing the feasibility of such orientation-patterned wave guides with standard fabrication techniques, using gallium arsenide as the starting material.DESCRIPTION OF WORKGOALS partners intend to focus their research effort on the study of the major obstacles that may hinder practical applications of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cross-species characterisation of CD8alpha+ dendritic cells and their role in immune regulation' (DCSUBSET).

assistant: **Innovation**

Dendritic cells (DC) are a heterogeneous family of leucocytes with important functions in immunity. Little is known about the role of distinct DC subtypes in vivo. In the mouse, a subset known as CD8alpha+ DC has been argued to represent a discrete DC lineage with specialised properties. These include a superior capacity for presenting exogenous antigens to CD8+ and CD4+ T cells, which makes CD8alpha+  DC an attractive target in vaccination and tolerisation. However, it is unclear whether CD8alpha+ DC fulfill unique and non-redundant roles in the immune system. In addition, the reported restriction of CD8alpha+ DC to thymus and secondary lymphoid organs is hard to reconcile with their documented capacity to act as presenting cells for antigens outside those organs. Finally, CD8alpha+ DC have not been identified in humans, greatly restricting their use in immunotherapy. In this proposal, we exploit the recent finding that DNGR-1 (CLEC9A) acts as a new and specific marker for the CD8alpha+ lineage to address these issues. We will generate DNGR-1-Cre mice as a universal tool to manipulate gene expression in the subset. We will use such mice to render CD8alpha+  DC sensitive to toxic proteins that permit constitutive or transient ablation of the subset for functional studies. DNGR-1-Cre mice will further be used to express fluorescent proteins in CD8alpha+ DC, allowing tracing of the lineage in vivo, both in lymphoid and non-lymphoid organs. Finally, we will use the DNGR-1 marker to identify and characterise putative CD8alpha+ DC equivalents in humans. The results from this proposal will illuminate the function of CD8alpha+  DC across species and open the door for using this intriguing DC subset in immunotherapy of cancer, infectious and autoimmune diseases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Autonomous Lander Instrument Packages for Oceanographic Research'.

assistant: **Objectives**

Autonomous landers that can conduct experiments and gather data on the sea floor have the potential to revolutionise oceanographic research. By using a number of landers, the spatial and temporal coverage of a single ship can be increased by orders of magnitude. Landers also enable small ships to carry out deep sea research without the need for wires extending to full ocean depth. Landers have been specified as a necessary component of all the major subsurface oceanographic research programmes, BENGAL,OMEX, JGOFS, HiBETS etc. European laboratories have already developed a variety of landers. An essential next step is for these to work together in a co-ordinated fashion. Landers from all the partners will be carried on a multi-lander cruise of the RRS Discovery in the North East Atlantic in 1996. This will comprise the largest fleet of landers (20) ever assembled and will be the prototype for future deep-sea oceanographic expeditions in the next century. This expedition, will confront for the first time the problems of inter-compatibility of systems and management of such a complex exercise. A diversity of landers will be deployed including monitoring of water column above the floor, tracking of abyssal fishes, probing the sediment, in situ chemical analysis, biological and metabolic studies. Following these experiences, during 1997 new technological solutions to lander engineering problems will be developed by the various partners. Work will be directed towards an advanced modular lander prototype for use from large oceanographic vessels. A complementary development will be undertaken of a compact lander designed for use from small vessels, which although based on islands or coastlines near deep-water have no means otherwise of sampling in the sea floor. The compact lan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'From LEAF to Terrestrial Biosphere Model: Integrating multi-scale observations of highly diverse tropical ecosystems for global scale simulations'.

assistant: **Concept**

The representation of terrestrial ecosystems is a key source of uncertainty in future projections of the coupled carbon cycle/climatic system. Current Terrestrial Biosphere Models (TBMs) represent the worldwide vegetation by a dozen of rigid Plant Functional Types (PFT), with empirical mechanisms calibrated on discrete observations. As a result, TBMs represent highly diverse ecosystems such as tropical forests with only one clone of the same plant. This over-simplified representation arises from the lack of observations in some regions such as over Africa, which leads to widely diverging results for C cycling and nutrient/water limitations under future scenarios.Simulating plant diversity is crucial for assessing global change impact on ecosystems and their feedback on climate.LEAF2TBM targets the unresolved challenge for TBMs to simulate the effects of plant diversity on tropical forest ecosystem functioning and associated global biogeochemical cycles based on an integrated assessment of processes across different scales. I will achieve this by using unique concomitant field observations of carbon dioxide and water vapor exchanges measured at multiple scales (from individuals to ecosystem) and state-of-the-art modelling approaches to ( 1 ) accurately quantify the effect of the functional diversity on ecosystems fluxes for two forests located in the Congo Basin and Amazon; ( 2 ) disentangle the roles of species composition and environment on ecosystems fluxes; and ( 3 ) provide a robust estimate of the global C budget uncertainty for tropical forests in TBMs. LEAF2TBM will enhance EU scientific excellence and will be a crucial step for guiding the development of the next generation TBMs that are central for policy decision making. The science excellence and training thr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Metabolic control of RNA-protein and RNA-RNA interactions in cellular transformation.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

In the current paradigm of gene expression, the structure of messenger RNA (mRNA) is a key element of posttranscriptional control because it modulates interactions with RNA-binding proteins (RBPs). RBPs typically recognize RNA-binding domains to form ribonucleoprotein complexes that ‘commit’ mRNAs to specific functions, and mutated or deregulated RBPs are implicated in multiple neurodegenerative diseases and cancer. Yet, the knowledge on the dynamic regulation of ribonucleoprotein complexes in mammalian cells is limited, mostly because the ‘structure’ and ‘specificity’ of RNA-protein interactions are amply unexplored. Recently, the host laboratory developed a new technique – hiCLIP – which identifies the transcriptome-wide RNA secondary structures (RNA duplexes) bound by particular RBPs, paving the way for pioneering research on the ‘structural determinants’ of RNA function in mammalian cells. In this context, N6-methyladenosine (m6A) is the most prevalent internal modification in mRNAs with critical functions in RNA stability, and seminal studies recently showed that m6A ‘marks’ destabilize in vivo RNA duplexes in the mammalian transcriptome. However, i) how m6A ‘marks’ regulate RNA-protein interactions that rely on RNA secondary structures is unknown, and ii) there is no systems-level elucidation of which RBPs are sensitive to m6A. Importantly, the ‘maintenance’ of m6A levels requires metabolic substrates and the m6A protein machinery is implicated in obesity and cancer. Collectively, these evidences point to a structural role of m6A in RNA function, and raise the compelling notion that metabolic control of m6A may represent a ‘regulatory module’ of gene expression in mammalian cells. The research proposed herein is designed to reveal the ‘regulatory principles’ of RN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mesoscale Quantum Dissipation with Applications to Nanotechnolgy' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Quantum dissipation arising from quantum fluctuations and the quantum mechanics of macroscopic variables is important because of the ever decreasing size (mesoscale) of the nanoparticles used in technology. The most striking example occurs in information storage by magnetic nanoparticles, where the governing factor for magnetisation reversal by macroscopic quantum tunnelling is spin size S. The S dependence, with associated large quantum effects, becomes evermore marked as one proceeds from single domain particles to molecular clusters to single molecule magnets to individual spins. Here in the context of a general investigation of mesoscale quantum mechanics of particles (separable and additive Hamiltonians) and spins it is proposed to generalise Wigner’s quasi phase space formulation of quantum mechanics without dissipation (originally used to calculate quantum corrections to classical statistical mechanics i.e. the quantum/classical borderline characteristic of the mesoscale), to systems with non-separable Hamiltonians (spins) including the effects of dissipation to the surrounding heat bath. The results, obtained by (a) matrix continued fraction methods of solution of the appropriate master equations (b) computer simulation and (c) quantum Kramers escape rate theory will be compared with suitable experimental observations of the escape rate and the associated susceptibilities of nanoparticles.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European CYber Security Protection Alliance' (CYSPA).

assistant: **Innovation**

The goal of CYSPA is to address trustworthy ICT through a European strategy to protect cyberspace, with target audiences ranging from research communities and industry to public authorities and infrastructure operators.This goal builds on the analysis that the entire cyberspace which embodies our connected society has been created by technology but evolving towards trustworthy ICT requires taking into account all dimensions, from human to legislative, from infrastructure to information, from economic to societal. This means addressing the issue at European level and prioritizing the initiatives based on economically validated metrics.CYSPA is proposed by 17 partners and 4 supporting organisations from industry and research, extending across 10 countries and promoting a top-down approach,-\tstarting from the economic and societal impacts of cyber disruptions-\tintegrating the role and expected impact of on-going initiatives-\tdetailing the capability needs through a solutions and technology observatory-\tevaluating the optimal uptake and deployment modelsto ultimately deliver and disseminate an integrated European strategy to protect cyberspace.In the short term, CYSPA is an ICT support action.In the mid-term, CYSPA is an alliance of stakeholders taking trustworthy ICT forward with a prioritised, evolving, industry and research supported, economically validated strategy and implementation lines.CYSPA delivers four major outcomes-\tcyber disruptions impact report and associated metrics-\ta technology & solutions observatory-\tintegrated European strategy for the protection of cyberspace-\tstructured community from providers to operators, making CYSPA evolve as a self-sufficient alliance beyond the lifetime of the CYSPA project.CYSPA innovates in moving from a bottom-up te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Biomarkers of individual differences in human cortical visual processing' (PUPILTRAITS).

assistant: **Concept**

Vision is probably the best understood system of the human brain: studying vision has taught us much about the human mind and its complex processes. We know in detail the fundamental steps leading to visual perception, but we do not know why normally sighted people differ in how they perceive: why some “see the forest before the trees”, while others have a fragmented perceptual experience focused on local features. PUPILTRAITS aims to fill this gap by taking an innovative approach to vision science, to understand how vision is affected by physiological state and personality traits.I will measure visual processing with both classic and new methods (that I helped develop), including pupil responses, ultra-high field Magnetic Resonance of human visual cortex, and psychophysics. Based on solid pilot data, I predict that differences in behavioral and cortical properties co-vary with personality traits, providing new reliable biomarkers of the local context-independent perception associated with autistics traits, even in young children (using pupillometry). These tools will also reveal changes of perception within individuals: during a safe and simple physiological intervention (ketosis, a metabolic state that can be naturally induced by fasting and intense physical activity), to show that early visual processing can be altered by acting on metabolism, and that this consequently affects holistic/local perceptual styles.My aim is to provide new knowledge on the relationship between metabolism, cortical processing and perception. This has the potential for a strong societal impact: it can change our understanding of pervasive developmental disorders, like Autistic Spectrum Disorders, characterized by a different way of processing incoming information; it can aid their diagnosis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'a Virtual Studio for Security Concepts and Operations' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The concentration of government buildings within urban environments has become a source of serious security vulnerability. Administrators and security experts face a variety of evolving threats that are hard to anticipate. To secure a government building against multiple threats while maintaining a minimal level of transparency and accessibility requires an integral security approach. It demands interdisciplinary collaboration between different experts from different domains. Currently, there is no efficient method or tool that allows the experts of different stripes to efficiently design, evaluate and implement appropriate security concepts. Existing ones do not allow for the effective creation, analysis, assessment, and sharing of security concepts that will help government administrators provide a secure environment for personnel and citizens.The VASCO project addresses two important objectives. First, it will design, implement and evaluate an innovative IT tool that will enable security professionals and administrators to jointly formulate, test, and adjust security concepts and measures in a virtual environment. This provides a cost-effective and risk-free environment in which to devise an evidence-based, all-risk approach for the protection of government buildings. Second, it will produce a knowledge and best practice database, which captures dynamic and visual reference scenarios created with the VASCO system.To accomplish these aims, the project will adopt an iterative methodology that enables the constant involvement of its world-class security and crisis management experts, assisted by a solid and open user group, during the whole project. It makes use of the latest advances in interactive visualisation, simulation, crisis management, and artificial intelligen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Combination of AI techniques and software with advanced reactor equipment for efficient kinetics analysis in the chemical industry (AITEKIN)' (AITEKIN).

assistant: **Innovation**

Reactors are the core elements of chemical processes, which consist of reactors and unit operations for the transformation of feedstocks into final products. 'Several advanced commercial products are available for both simulation and optimisation of unit operations under steady and transient conditions. This is not the case for chemical reactors, due to the variety and complexity of industrial reactions: in most commercial simulators the description of reactions is left to the user. This requires many experiments and the skill of highly qualified theoretical chemists, which can lead to unacceptably high costs. They can be reduced by software tools for the identification of arbitrarily complex kinetics and for the advanced control based on this identification step. The project result is a prototype plug flow reactor with the necessary hardware to carry out temperature scanning kinetic experiments and the AI based software necessary to identify the kinetic mechanism, and design the industrial scale reactor and its control system with little human involvement. This objective can be divided into a number of intermediate steps, each of which is an important result of its own: A laboratory plug flow reactor for temperature scanning experiments. The automatic generation of reaction schemes, using graph theory with the possibility of modifying the kinetic mechanisms suggested by this expert system. A,symbolic translator from a chemical to an algebraic language for further data analysis. The rigorous regression analysis of temperature scanning experiments data, based on sensitivity equations, followed by model discrimination, if more than one kineti c mechanism was found. The design of an industrial scale reactor, its optimal control system and the automatic generation of comput