RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Ecosystem for Collaborative Manufacturing Processes – Intra- and Interfactory Integration and Automation' under Horizon 2020.

assistant: **Concept**

Data and services have become the key factor in manufacturing processes. The need to react on dynamically changing market demands is dramatically rising. One of the most imperative problems so far is to connect supply chain data and services between enterprises and to connect value chain data within a factory, so that it can meaningfully support decision-making. COMPOSITION will create a digital automation framework (the COMPOSITION IIMS) that optimizes the manufacturing processes by exploiting existing data, knowledge and tools to increase productivity and dynamically adapt to changing market requirements. This technology acts as the technical operating system for business connections between factories and their suppliers. Furthermore, it opens a new space for third party entities to actively interact in the supply chain, e.g., by providing services to improve cycle time, cost, flexibility or resource usage. In addition to the supply chain improvements, also the processes inside the company will be addressed and optimized. Data across the (multi sided) company internal value chain is integrated by an Integrated Information Management System (IIMS) with optimisation and modelling tools for resource management including innovative, multi-level, real-time cross-domain analytics including a Decision Support System. The technology will be based on extending existing FI-WARE and FITMAN catalogues and LINKSmart® Middleware and adapt the concept of Industrial Data Space. COMPOSITION will implement, demonstrate and validate the system in two multi-sided pilots that show the modularity, scalability and re-configurability of the platform across multiple application domains. The first pilot in the biomedical device domain focuses on the integrated information management system in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Mitochondrial protein characterisation and interaction prediction' (MIPCHIP), addressing dissemination and exploitation.

assistant: **Impact**

Recent work suggests that all eukaryotes, irrespective of their lifestyle, anaerobic or parasitic, contain an organelle derived from the mitochondrion a mitochondrial homologue, posing the question is there a common conserved function shared by all mitochondrial homologues that makes them vital for the eukaryotic cell?I will use an innovative comparative bioinformatics approach to identify the cohort of mitochondrial proteins conserved among genomes of diverse parasitic and anaerobic eukaryotes with mitochondrial homologues of different sorts (including hydrogenosomes and mitosomes), and contrast these with the well-characterized proteomes of classic aerobic mitochondria from model organisms.I will also investigate how these proteins might potentially interact and thus infer a mitochondrial functional interactome. These analyses will identify the best candidates for a common essential function (if one indeed exists) for the mitochondrial organelle under diverse living conditions, but will also illustrate the variability of this apparently vital eukaryotic organelle.I will do this work at Newcastle University in the laboratory of Prof. Martin Embley, an expert on mitochondrial homologues of parasitic protozoa. My skills in bioinformatics complement those of Prof. Embley and his collaborators ensuring an excellent synergy and training environment and, through collaboration with researchers in Prof Embleys lab, a unique opportunity to use computational biology to direct focused cell biology.My project is innovative and original and addresses major EU concerns: investigating the functions of organelles of important human parasites addresses a specific goal of EU priority Advanced Genomics and its applications for Health (OJL294, 29.10.02). My project will also provide basel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deciphering Cancer Heterogeneity and Drug resistance using Single-Clone Genomic and Epigenomic Landscapes' (CancerMultiOm) under Horizon Europe.

assistant: **Objectives**

To comprehend the characteristics, phylogenetic relationships, and drug resistance of tumor subclones, measurements must be performed at single-cell or single-clone resolution. Aims 1 and 2 aim to create cost-effective and reliable single-cell drop technologies for capturing full-length RNA (Scfl-RNA-Seq) and enhancers at the DNA level (ChromOpen). It is noteworthy that Scfl-RNA-Seq also captures non-coding and non-polyadenylated RNAs besides coding mRNA. ChromOpen also offers better capturing of functional enhancers and higher sensitivity compared to the conventional technology. The ultimate goal of Aim 3 is to create the first technology that can capture both full-length RNA and enhancers from the same cell (Multi-Omics). To increase sensitivity and coverage, Multi-Omics will be combined with a 3D-culturing system (3Dclone) that facilitates growth of primary cancer cells into small clones. The single-clone based Multi-Omics maps will increase the discovery rate of genetic somatic diversity, including non-coding regions, reveal connections between gene expression and mutated loci, and display a wider range of functional state associations between cells. In Aim 4, using our innovative mapping technologies, we will investigate two brain tumors: Non-Small Cell Lung Cancer that has spread to the brain and Glioblastoma primary cells. Both of these cancers have limited treatment options and poor outcomes due to drug resistance. Based on temporal drug treatment experiments and advanced mapping technologies, this data will improve our understanding of somatic driver mutations and cellular diversity in the context of resistance, and ultimately, lead to the identification of new therapeutic targets.


**Keywords:** Single cell technologies, High Throughput Sequencing, Epigenomic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Cavitation monitoring in hydraulic machines with aid of a computer aided visualization method', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Scientific objectives:- gain new fundamental knowledge of physical phenomena of cavitations in hydraulic machines with aid of a recent computer-aided visualization method.Technical objectives- the employment of the above mentioned fundamental knowledge along with new method of computer-aided visualization and develop a new, direct method of cavitations detection and monitoring on vital parts of hydraulic machines, .increase turbine operating range due to exact definition of cavitations limits, which are continuously monitored. The monitoring will be performed on a model of hydraulic machine as well as on a prototype - real hydroelectric power plant turbine.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'hiErarchical metal-orgaNic framework@covaLent organic framework (MOF@COF) on carbon nanofIbers for electrocatalytic CO2 conVErsioN' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Electrocatalytic CO2 reduction (ECR) reaction offers a powerful strategy to enable a circular economy that converts CO2 from a waste to a useful resource. Among the possible catalysts for the ECR, metal-organic frameworks (MOFs) offer a tunable porous structure for rapid mass transport and easy access to a high density of catalytic sites, which can be tailored at the molecular level, leading to superior activity. Moreover, copper-based MOFs (Cu-MOFs) show relatively low cost and ability to form C2+ products. However, the low selectivity, poor stability and electrical conductivity set obstacles for ECR applications of these materials. The ENLIVEN project aims to surpass these limits, through the combination of Cu-MOFs with highly stable and conductive covalent organic frameworks (COFs) forming core@shell MOF@COF thin films on mesoporous conductive carbon nanofibers (CNFs). To this aim, CNFs prepared by electrospinning will be covered by a homogenous metal oxide layer and then pyrolysed to produce metal seeds for the solvothermal growth of homogeneous crystalline Cu-MOF-NH2 layers. Then, the NH2 functionalized surface will be modified with aldehyde groups necessary for the growth of a COF layer. To allow tuning the selectivity towards the ECR and decreasing the competing hydrogen evolution reaction, superaerophilic electrodes will be assembled using COF ligands with hydrophobic groups and designing a special morphology. Also, ENLIVEN will study the new confined chemistry that takes place inside the pores of  MOF@COF architectures, rationally designed from the molecular- through nano- to meso-scale. This knowledge will provide the blueprints for the development of more durable and efficient electrocatalytic materials. The project will be conducted in UNIPD and DTU (secondm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Nanopores for New Molecular Nitrogen Chemistry'.

assistant: **Objectives**

We will study the adsorption, binding, transport and reactivity of N-containing substrates within the nanopores of functionalized and doped metal-organic framework (MOF) materials. A range of important target molecules (e.g., NH3, N2H4, N2O, NO, NO2 and N2O4) will be studied in this project, which aims to re-define the molecular chemistry for these energetic N-compounds in confined space, and to develop selective catalytic reduction (SCR) of NOx in the presence of NH3, urea and hydrocarbons. The PI has extensive experience in the field of coordination chemistry and hybrid materials, and seeks to change research direction to develop new gas phase catalysts and to gain fundamental understanding of molecular interactions, properties and function of specific energy, environmentally-related substrates within MOFs. Research objectives include the:• Design and synthesis of new porous MOFs with emphasis on the decoration of their pore environment and improvement of their structural stability and function; • Characterisation of host and substrate-loaded materials by state-of-the-art in situ structural, dynamic and spectroscopic methods for the construction of structure-function relationships, supported by computational analysis and modelling;• Adsorption, binding, release and separation of NH3, N2H4, N2O, NO, NO2 and N2O4 via both static and dynamic experiments;• Tests of degradation and selective catalytic reduction (SCR) of captured NOx molecules with NH3, urea and hydrocarbons under mild conditions using nanoporous MOFs as host catalysts; • Assembly of a MOF-based (i) catalytic deNOx reactor and (ii) NH3 storage system for potential portable applications. This project will deliver new functional materials as high capacity portable NH3 stores, efficient capture medium for NOx,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding Arctic amplification of climate change through air-mass transformations' (A3M-transform).

assistant: **Innovation**

We expect that temperatures over the wintertime central Arctic will increase by 20 degrees - and precipitation will double - by the end of this century if greenhouse gas emissions continue to rise. Arctic sea-ice is projected to completely melt in summer within the next decades, and may cease to form in winter in the coming century. The traditional framework to understand this Arctic amplification of climate change focuses on the steady-state mean Arctic climate.  However, the Arctic wintertime atmosphere has two preferred states that are largely controlled by initially warm and moist air masses that cool and dry after being advected from lower latitudes. We understand little about how these air masses cool and dry, and what controls the sudden transition from a cloudy state to a clear state along their trajectory. This lack of understanding is a major obstacle to scientific progress and improved climate models.  To achieve groundbreaking progress, I will analyze the warm, moist poleward flows, cold, dry equatorward flows and the air-mass transformations that lead from one to the other. I will observe and model such air masses along their trajectories using recently developed air-mass following balloons and customized model setups. Cooling of air in the Arctic mirrors heating in the Tropics. Together, these drive the global atmospheric circulation, but the Arctic’s role in this picture has largely been overlooked. My team will investigate how the Arctic couples to the global climate system using a novel concept of averaging the atmospheric circulation. We will focus on how and why both the heat and moisture content and the amount of air transported into and out of the Arctic change in a warming world and contribute and respond to Arctic amplification.A3M-transform will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Environmental Risk from Ionising Contaminants: Assessment and Management (ERICA)' (ERICA) under Sixth Framework.

assistant: **Objectives**

The objective of ERICA is to provide an integrated approach to scientific, managerial and societal issues cerned with the environmental effects of taminants emitting ionising radiation, with emphasis on biota and ecosystems. The final outcome of the project will be the ERICA integrated approach to assessment and management of environmental risks from ionising radiation, using practical tools. The project will partly build on the achievements of the FASSET project, which provided a basic framework for the assessment of environmental impact of radionuclides. The objectives of the ERICA project will be fulfilled through development of a user-friendly assessment tool with risk characterisation methodologies coupled with communication strategies aimed at decision-making. This involves detailed sideration of gaps in scientific data, expansion of the current effects database, and experimental and theoretical sideration extrapolation issues, e.g. from effects on individuals to effects on populations. The tool will be tested and applied to a series of case studies and supported by stakeholder interaction. The development of science-based managerial guidance, including methodologies for stakeholder involvement in assessments, will be based on a number of meetings with end-users representing a range of different interests, whom have agreed to participate in ERICA. The meetings will be cerned with different scientific and managerial aspects of assessments, including the development of methodologies to derive standards. Emphasis will be put on disseminating the progress of the work through tinuous interaction with the end-users. A workshop will be organised towards the end of the project to demonstrate to end-users how the integrated approach developed within this project can be pra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Muslim Individual in Imperial and Soviet Russia' (MIND), addressing dissemination and exploitation.

assistant: **Impact**

For European historiography, it is self-evident that diaries, correspondences, and other personal documents provide crucial insights not only into how individuals thought about certain issues, but also in how the authors expressed their individuality, and how they saw their active role in history. This holds true both for prominent and ordinary persons, and for a whole variety of genres. In the historiography of Muslim societies, expressions of individuality are rarely ever problematized; the individual is often seen merely as part of a faith community, and the writings of individuals are more often than not just treated as a source for factual information on Islam, politics, or broader social phenomena, not as an effort of personal self-reflection.By analyzing practices of individualization in the personal archives of Muslims in Russia, this program places the Muslim subject at the center. How does a person engage with the Islamic tradition, with the demands of the state and the non-Muslim majority society, but also with other individuals, to design his or her conception of the self (Ar., shakhsiyya)? How is this individuality communicated to others, in letters about love, friendship, or a plethora of other personal matters (SP1)? What is the role of aesthetics in the narratives of the Muslim subject – how does a self-concept obtain a literary form, for instance when experiences are turned into poetry (SP2)? How do Muslims characterize other Muslims when they produce biographies (SP3), and how do they portray themselves in autobiographies (SP4)? And finally, how do Muslims employ photography for expressing their individuality, their belonging to tradition or to the contrary their difference; and how did visual self-conceptions develop, according to personal tastes, val
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Individualised Diagnostics and Rehabilitation of Attention'.

assistant: **Objectives**

We propose a training network based around a linked set of research projects which attempt to improve the diagnosis and rehabilitation of neuropsychological disorders of attention, with each project linked to an external industrial partner in order to commercialise emerging diagnostic and rehabilitation procedures. New diagnostic procedures will link clinical measures of attentional disorders to a detailed mathematical account, which can in turn be linked to computational models of neuronal function. These behavioural measures will be integrated with brain imaging indices (using fMRI, EEG, MEG) to explain attentional disorders at a neural as well as a functional level. The emerging diagnostic procedures will be used to target individualised rehabilitation for patients, assessing effects of direct brain stimulation, EEG-based biofeedback, cognitive training of attention, and drug intervention. Each project will operate across both academic and industrial partners in the network, giving a unique commercial orientation to the training. Overall the project will advance neuropsychological diagnostics and rehabilitation, while giving trainees state-of-the-art inter-disciplinary research and entrepreneurial skills.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanistic links between rheumatoid arthritis and cardiovascular complications: investigation on inflammation induced alterations in induced pluripotent stem cell-derived cardiomyocytes' under Horizon 2020.

assistant: **Concept**

The aim of this project is to uncover the mechanisms by which patients with rheumatoid arthritis (RA) may have an elevated risk of cardiovascular complications. In particular, we will determine the role of the inflamed joint microenvironment in promoting cellular bioenergetics of cardiomyocytes. We aim to test the hypothesis that cardiomyocytes of RA patients reflect the features of pathological changes that might indicate for the cardiac vulnerability characteristic for this disease. This proposal has three specific objectives: (1) To examine whether exposure of control and RA-specific induced pluripotent stem cells-derived cardiomyocytes (RA-iPSC-CMs) into a joint-like environment recapitulate a cardiac disease-like state; (2) to determine the effect of a joint-like environment on cellular bioenergetics of control and RA-iPSC-derived CMs; and (3) to test whether control and RA-iPSC-CMs can act as a tool to identify potential cardioprotective/cardiotoxic treatment strategies used in RA.This project proposes a truly translational, bench-to-bedside approach building on the strength of the human RA model. We will establish a unique source of functional cardiomyocytes by reprogramming RA synovial fibroblasts and peripheral blood mononuclear cells to iPSC. To investigate the impact of the joint inflammation on cardiomyocytes’ bioenergetics and transcriptomic profile, the state-of-the-art technologies will be applied. The most advanced cell metabolism analyser will be used to quantify real-time measurements of mitochondrial respiration and glycolysis. Global analysis of mRNA and miRNA transcriptome by RNA-seq will allow identifying new cardiomyocyte-specific genes/pathways that might affect cellular metabolism in RA. Using iPSC-CMs will provide a unique opportunity to examin