RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Condition specific RNA Regulatory Maps'.

assistant: **Concept**

RNA-binding proteins (RBPs) regulate the processing and expression of protein-coding transcripts. The goal of the proposed research is to develop a strategy to determine specific mRNA regulatory factors and elements important for investigating any biological processes. First, we will construct a transcriptome-wide post-transcriptional regulatory map of RBP-mRNA interactions by probabilistic modeling of protein occupancy profiles and RNA sequence data, simultaneously inferring binding locations of numerous of RBPs for a specific experimental condition. Next, we will predict specific RBPs with important regulatory functions in a different experimental setting by applying our model to protein occupancy profiles generated from different cellular conditions. Specifically, we will generate protein occupancy profiles for a human adrenocortical cell line stimulated with the primary physiological regulators of adrenal steroid hormones to examine the production of mineralocorticoids, glucocorticoids, and adrenal androgens. This research proposal necessitates a combined wet/dry approach including the complete cycle of genome-wide predictive modeling and experimental validations. The research in this proposal benefits from the molecular biology and genomics background of the Experienced Researcher combined with the computational modeling expertise of the Host Laboratory. This research has transformative potential for the field by effectively learning specific RBP-mRNA interactions from computational modeling of a single experiment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Land use, Sustainability, and Democratic Backsliding'.

assistant: **Innovation**

Land use and land systems, i.e. how human societies manage and interact with land through social-ecological systems, are at the core of sustainability issues. Democratic backsliding, i.e. the decline or degradation of theinstitutions and social norms that sustain democratic societies, is a widespread and impactful trend, with strong but understudied two-ways linkages with land use dynamics. In LUDEMO, we will make key contributions to understanding the linkages between these issues, with (i) explicit articulation and embedding of democratic backsliding concerns and knowledge within land system and sustainability science – moving beyond a focus of democratic backsliding research on social, economic and political aspects, and beyond a focus of sustainability science on policy rather than politics – ; (ii) spatial, quantitative causal analyses of linkages between multiple forms of democratic backsliding and land use changes and related environmental impacts – moving beyond mostly qualitative, political analyses – ; (iii) syntheses and theory building on these two-way interactions. We will investigate these issues through cross-country studies as well as the three focal cases of reactionary forces and agrarianism in Europe’s consolidated rural areas, extractive populism in Canada’s Northern frontiers, and agrarian authoritarianism in Mozambique’s smallholder landscapes.


**Keywords:** land system; democracy; social-ecological systems; Earth Observation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Comparison and rigidity for scalar curvature' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Questions involving the scalar curvature bridge many areas inside mathematics including geometric analysis, differential geometry and algebraic topology, and they are naturally related to the mathematical description of general relativity. There are two main flavours of methods to probe the geometry of scalar curvature: One goes back to Lichnerowicz and uses various versions of index theory for the Dirac equation on spinors. The other is broadly based on minimal hypersurfaces and was initiated by Schoen and Yau. On both types of methods there has been tremendous progress over recent years sparked by novel quantitative comparison and rigidity questions due to Gromov and by on-going attempts to arrive at a deeper geometric understanding of lower scalar curvature bounds. In this proposal we view established landmark results, such as the non-existence of positive scalar curvature on the torus, together with the more recent quantitative problems from a conceptually unified standpoint, where a comparison principle for scalar and mean curvature along maps between Riemannian manifolds plays the central role.Guided by this point of view, we aim to develop fundamentally new tools to study scalar curvature that bridge long-standing gaps in between the existing techniques. This includes a far-reaching generalization of the Dirac operator approach expanding upon techniques pioneered by the PI, and novel applications of Bochner-type methods. We will also study analogous comparison problems on domains with singular boundary motivated by a first synthetic characterization of lower scalar curvature bounds in terms of polyhedral domains, and by the general quest for extending the study of scalar curvature beyond smooth manifolds. At the same time, we will treat subtle almost rigidity que
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Investigation of the normal function of the genes syt, ssx1 and ssx2 involved in the t(x;18)(p11.2;q11.2) human synovila sarcoma translocation' under Fourth Framework.

assistant: **Concept**

During the years a number of specific chromosome translocations have been identified in several classes of soft tissue sarcoma. In Dr. Coopers laboratory the translocation t(X;18)(pll.2;qll.2) found in synovial sarcomas has recently been identified. They showed that during this translocation fusion genes are created between the SYT gene on chromosome 18 to either SSX1 or SSX2 on the X chromosome. These genes were also cloned and were identified as novel genes. In the project that I will work in, the normal functions of the SYT, SSX1 and SSX2 proteins will be studied. The mechanism of the SYT-SSX1 and SYT-SSX2 fusion proteins in cellular transformation will also be studied. A third aim of this project is to investigate the possibility to use antibodies against SSX1 and SSX2 proteins in tumour diagnosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Adsorbent carbons for the removal of biologically active toxins' to be submitted under Seventh Framework.

assistant: **Abstract**

The aim of the project is to manufacture an adsorbent carbon based cartridge within a perfusion system for the removal of strongly, protein bound and macromolecular toxins and inflammatory molecules including hepatic and uremic toxins, exotoxin, endotoxin and cytokines. These molecules are responsible for systemic toxicity effects and their removal is negligible or unsustained in current systems available for the treatment of renal, hepatic and multiple organ failure (MOF) related to sepsis. Additionally, removal of these molecules during perfusion of organs for transplant will moderate the inflammatory stress response which currently limits the success of marginal organs. The project considers economical and environmental impact in the development of processing strategies which optimise the adsorptive, biocompatible and hydrodynamic design properties of the resultant system for these applications. The project brings together a multidisciplinary consortium of specialists with many years experience in the development, analysis and clinical implementation of adsorbent biomaterials in extracorporeal systems and in the development of transplant organ preservation techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Secretariat of the European Technology and Innovation Platform on Renewable Heating and Cooling in 2022-2025', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

This proposal aims at supporting the work which has been carried out by the secretariat of the European Technology and Innovation Platform on Renewable Heating and Cooling since 2009. The role of the secretariat is to assist the stakeholders of the RHC-ETIP in coordinating activities related to the implementation of a research and innovation strategy to increase the use of renewable energy sources for heating and cooling in line and supporting the targets set by the European Green Deal, as well as to foster the growth and the market uptake of the RHC technologies. The secretariat provides support to the structure of the RHC-ETIP, by organising meetings, events, and relevant consultations, and by assisting with the preparation of relevant documents (both of technical and of political nature) to raise the profile and importance of the renewable heating and cooling sector, and its related technologies. It also provides consensus-based strategic advice to the SET-Plan and will play an active role in the planned update of the SET-Plan in 2022. This proposal keeps the emphasis on the need to enlarge the membership of the RHC-ETIP by involving more closely policy makers and RHC stakeholders on the national level, as well as other relevant stakeholders (i.e. new markets for the H&C demand side, and socioeconomic experts) in its work. This proposal adds stronger emphasis on the RHC industry through establishment of RHC Accelerator and the development of the RHC industrial strategy. By supporting interactions between the many stakeholders representing industry, research and academia, from different renewable heating and cooling technologies, and by further inclusion of complementary sectors and expertise, the SecRHC-ETIP will assist the RHC sector in strengthening its growth and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Longing for a good night's sleep: A memory-based mechanism to improve sleep and cognitive functioning.', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Sleep is critical for optimal cognitive functioning and health. Sleep disturbances are highly frequent in our society and strongly influenced by cognitive factors, e.g. rumination, expectations and thoughts. However, the mechanism of how cognition influences sleep architecture is not yet understood. To explain how cognition influences sleep, I propose the “Memories-of-Sleep” (MemoSleep)-Hypothesis. Based on the theory of embodied cognition and evidence that memories are reactivated during sleep, the MemoSleep-Hypothesis makes the following assumptions:(1) Cognitions related to sleep/wake states are embodied. I will call them embodied sleep/wake memories. Embodied sleep/wake memories encompass not only their semantic meaning, but also their sensorimotor body representation. Thus, the mental representation of the word ‘wake’ is directly linked to our body sensation of wakefulness.(2) If embodied sleep/wake memories are activated before sleep, they will have a higher probability of being reactivated during sleep.(3) During sleep, increased reactivation of embodied sleep/wake memories activates associated body responses and thereby affects sleep architecture. Thus, increased reactivation of the mental representation of ‘wake’ will activate wake-related physiological responses and disrupt sleep.Here I aim at empirically testing these assumptions using brain imaging (high-density EEG, EEG/fMRI) and cognitive testing in humans. I will show that activation of embodied sleep/wake memories before and during sleep influences sleep architecture and affects post-sleep cognitive performance. In addition, I will apply these findings to the elderly and patients with sleep disorders. The results will greatly enhance our theoretical understanding of how cognition influences sleep. Furthe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Development of a new event generator for lhc' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The goals of the research project can be summarized as the further development of the program package APACIC++/AMEGIC++ designed for the simulation of particle collisions at high energies. Such simulation programs are indispensable tools for the interpretation and quantitative analysis of experiments on sub nuclear scales i. e. in the realm of particle physics. In the framework of future experiments with rising energies (for instance LHC, TESLA), new physical phenomen pose a challenge on such programs necessitating more refined solutions, both on the physics and on the implementation level . The new program package APACIC++/AMEGIC++ follows the requests of the community, being programmed in an object oriented style in the language C++. Included in this package, a new developed approach to combine matrix elements and parton showers has been implemented for the first time. The goal now is to extend this concept and the program itself from the well understood electron positron annihilation processes of the LEP era to the proton proton collisions investigated at the LHC at CERN, Geneva. For this, the following steps have to be achieved:1. Parton shower in the initial state;2. their combination with matrix elements;3. inclusion of unstable particles in the final state parton shower;4 . inclusion of models beyond the Standard Model into the matrix element generator AMEGIC++ and its improvement.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Study of Strongly Interacting Matter', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The Project promotes the access to five European Research Infrastructures, and it is structured intop eight Networking Activities, plus the Management of the Consortium, and fourteen Joint Research Activities. The Project represents the continuation of the successful HadronPhysics project in FP6 and originates from the initiative of more than 2.500 European scientists working in the field of hadron physics. Hadron physics deals with the study of strongly interacting particles, the hadrons. Hadrons are composed of quarks and gluons. Their interaction is described by Quantum Chromo Dynamics, the theory of the strong force. Hadrons form more complex systems, in particular atomic. Under extreme conditions of pressure and temperature, hadrons may loose their identity and dissolve into a new state of matter similar to the primordial matter of the early Universe. The Networking Activities are related to the organization of experimental and theoretical collaborative work concerning both ongoing activities at present Research Infrastructures and planned experiments at future facilities. In hadron physics the close interaction between experimentalists and theoreticians is of paramount importance. The Joint Research Activities concentrate on technological innovations for present and future experiments. Applications in material science, medicine, information, technology, etc., represent natural fall-outs. The main objective of this Integrating Activity is to optimize the use and development of the Research Infrastructures existing in Europe working in the field of hadron physics. The Project aims as well at structuring, on European scale, the way Research Infrastructures operate, and at fostering their joint development in terms of capacity and performance. The approach used is the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Atmospheric Carbon Capture' in the context of a Seventh Framework call.

assistant: **Objectives**

Carbon emissions from fossil fuel combustion and change in land use are forcing a rapid increase in atmospheric CO2 levels leading to climate change. The initial implementation of plans to reduce the levels of CO2 is based on a combination of increased use of renewable energy and the implementation of carbon capture and storage from industrial sources and power plants on a wide scale.Such actions are not sufficient for preventing the cross with the maximum limit CO2 concentration in atmosphere (550ppm), which is foreseen for 2060.CO2 capture directly from the atmosphere (air capture) would provide an option to accelerate the correction and possibly reverse the trend in atmospheric CO2 concentrations.Air capture may be a very affordable solution for mitigating climate change, solving the problem with distributed emissions and giving the possibility of locating the air capture unit close to geological storage facilities.Due to the recent high level of CO2 concentration in atmosphere, CO2 capture from the atmosphere represents the most recent strategy among the solutions for capturing carbon and for this reason the feasibility of air capture is still to be demonstrated.Using adsorbent materials can be considered as the most convenient way in terms of costs and energy consumption to develop a prototype of air capture system.Therefore the present project proposes an investigation oriented to develop a prototype for air capture adopting adsorbent materials and integrated with renewable energy sources to reduce energy consumption.The aim of the project is to demonstrate the ability of the novel adsorption device to capture CO2 from air at 400ppm (present atmospheric concentration), concentrate it and pressurise it with low temperature thermal energy.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Raman Active, Smart Diatom Frustules as Next Generation Multimodal Theranostics for Safe and Superior Colorectal Cancer Treatment' (DIASHUTTLE) targeting Horizon Europe.

assistant: **Abstract**

Colorectal cancer accounted for 12.7% of all new cancer diagnosis and 12.4% of all deaths due to cancer in European Union in 2020. Despite the advances in therapeutics, it is the most recurrent tumors in humans and third common cause of cancer-related deaths worldwide. The current treatment options include chemotherapy, radiation and surgery that are invasive and have side-effects. Also, the 1st and 2nd generation nanocarriers used in cancer therapy consisted of mono-component systems and failed due to lack of targeting molecules, remotely controlled therapeutics window, and patient-specific individualized platforms. The project DIASHUTTLE aims to develop a novel, next-generation, smart, multifunctional and multimodal, hybrid nanotheranostic platform consisting of biosilica extracted from living diatoms for simultaneous diagnosis, treatment, and therapy monitoring of colorectal cancer. It will combine magnetic nanoparticle core, surface deposited metallic gold nanoparticles, tumor targeting biomolecule folic acid, and natural source drug astaxanthin to facilitate different modes of therapy such as magnetically guided or ligand targeted drug delivery, magnetic hyperthermia, and photothermal therapy. It will also concurrently enable different modes of real-time monitoring such as Raman, surface enhanced Raman spectroscopy, magnetic resonance imaging, fluorescence, and photoluminescence. It is expected that the combination of different therapies will exhibit superior synergistic anti-cancer effect over monotherapy and reduce treatment delays by offering a safe and personalized approach to overcome the limitations of conventional cancer treatment. The proposed platform will lead to less toxicity due to the use of targeting molecule and natural materials, controlled drug rel