RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Molecular mechanisms controlling axonal development and synapse formation'.

assistant: **Concept**

During nervous system development, neurons generate more axonal processes than ultimately survive; some of these axonal branches are pruned, whereas others are stabilized to constitute a mature neuronal network. Relatively little is known about the molecular mechanisms that control axonal branch formation and stabilization. Functional analysis of diverse molecules during development has been carried out by means of the generation of regular mutant mice. However, the early mortality of these mutants has prevented their analysis during postnatal development, particularly in the central nervous system. To overcome this problem, conditional-mutant mice using the Cre/LoxP recombination system has been generated.Using this technology, the production of mice lacking a gene of interest in a tissue or cell-type specific-manner has been possible. In our previous studies, we have used conditional-mutants to investigate the function of the focal adhesion kinase, FAK. We have demonstrated that FAK is a positive cue for a xonal elongation and a negative cue for axonal branching, and consequently synapse establishment. The aim of this proposal is to characterize the molecular mechanisms by which FAK is controlling axonal development and synapse formation.Using cell-specific ablation in cortical cultures we propose to accomplish three fundamental goals:(1) to determine the role of local FAK in axonal elongation and branching in vivo,(2) to establish the downstream pathways following FAK activation, and(3) to unravel possible extra-cellular cues that use FAK as an intracellular mediator during axonal development.I anticipate that some of the insights of this research will increase our understanding not just of the initial development of neural connections but also of normal plastic rear
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a commercial manufacturing process for a low cost, small footprint, high efficiency fully electric compressor and power controls to fulfil a market need for use in heavy goods vehicles' (HiPower), addressing dissemination and exploitation.

assistant: **Impact**

Equipmake Ltd have a deep history of developing innovative technologies for niche and specialist markets such as Formula 1. Increasing demand for electrification in the commercial vehicles (CV) sector has created a new market for our electric traction motor and ultra high speed motor to create a highly efficient electric compressor for the CV sector. New legislations are creating an acute need and market pull amongst CV manufacturers for innovative solutions to meet new emission targets. The need is most acute amongst Heavy Goods/Commercial Vehicle (HGV/HCV) manufacturers.From this September, all new cars and light vans must abide by the new Euro6 regulations, and will be enforced for all HGVs by 2018. Over the past 23 years, the Nitrous Oxide (NOx) and Particulate Matter (PM) levels have been targeted with an overall 99% reduction. NOx is highly dangerous and linked to premature deaths and other health complications. The new standard requires a 55% drop in NOx from Euro5 of 180mg/km. This is bringing an increased need for electrification in the transport sector , creating a need for cost effective electric and hybrid technology for vehicles.HiPower will address this market opportunity with tests showing that we have a 66% smaller, 66% lighter compressor which is 50% cheaper, bringing both weight and cost savings to end users with a 22% increase in efficiency compared to nearest competing solutions. Calculations show that HiPower will create savings of 9,413 kg CO2 HGV/annum in conventional diesel engines and 1,552 kG CO2/bus/annum on electric buses in addition to the €5.9k saving on battery cost over normal compressors. We will create market entry using low hanging fruit of the electric bus market to then penetrate the high volume HGV market. 5-year gross profits of €1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on '8 X 2.5 Mw Wind Turbines With Crane-free Erection to be Implemented in Estonia'.

assistant: **Innovation**

Several factors have stimulated the trend towards bigger and bigger wind turbines:- Economics of scale;- Scarcity of sites & off-shore locations;- Learning curve of the technology These factors are still in full play, and stimulated by new technical concepts it is proposed to initiate a combined research and demonstration project with the aim of developing a new tower/erection concept for a 2.5 MW wind turbine and to demonstrate the viability of the concept in a 20 MW wind farm at Paldiski, Estonia. The project aims to carry out all the research, development and engineering necessary for the implementation of 8 pcs. 2.5 MW wind turbines, erected and commissioned without the need of cranes. The target for reduction of the cost of energy is from at present about Euro 0.04/kWh to about Euro 0.035/kWh.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unified No-Code platform for Interactive Cultural Heritage Experiences' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The UNICHE project aspires to co-design and create an intuitive, technology-agnostic ""black-box"" platform as a “no-code”, single-entry, collaborative tool for effortlessly designing, producing and sharing high-quality, interactive, cultural heritage experiences. With its user-friendly system, CH institutions and professionals, researchers, CI freelancers and resource limited players will be able to collaborate and generate high value interactive content in multiple formats (multimodal). UNICHE’s approach prioritizes ease of use and minimizes the technical expertise required, ensuring broad accessibility for diverse users and their audiences.By leveraging and integrating existing advanced technologies and tools developed by the consortium, UNICHE’s platform (Repository, Authoring Environment, Experience Apps and Evaluation tool) addresses in a holistic way the four E’s: Exhibits, Experience design, Exhibitions and Evaluation processes. Direct access and inclusion of exhibits from existing data spaces at the EU and Member States’ levels through the European Collaborative Cloud for Cultural Heritage (ECCCH) is a fundamental aspect of the project, addressing key challenges in cultural heritage institutions. The cultural content (exhibits) channeled through the ECCCH is utilised and repurposed in the AI-assisted Experience design process and presented through the Exhibition phase (Onsite, Hybrid and Remote), in which Evaluation processes are put in place to inform the enhancement of visitor engagement. UNICHE’s approach will firstly be evaluated in Pilot scenarios that represent diverse cultural heritage settings: open-air archaeological sites, museum permanent exhibitions and portable exhibitions and secondly will be further tested through an open call to third parties, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Optimisation of high temperature superconductors dc-squids device structures for its incorporation into an squid microscope' to be submitted under Fourth Framework.

assistant: **Abstract**

Research objectives and content The objectives of the project are: (1) Optimisation of High Temperature Semiconductors (HTS) dc- Superconducting Quantum Interference Devices (SQUIDs) device structures by submicron photolithography and ion beam etching in order to tune the critical current and enhance the dynamic resistance for application of APF. (2) Design of the first version HTS dc SQUID system with additional positive feedback (APF) and external control electronics for tuning with reset function. (3) Improve the design by incorporating HTS inductors and input coil structures based on our HTS multilayer technology. (4) Incorporation of the optimised HTS dc SQUID systems into the SQUID microscope. (5) Biomagnetic investigations with the SQUID microscope. Training content (objective, benefit and expected impact) - Deposition of HTS thin films and multilayers by laser ablation. - Characterisation of thin films by x-ray, SEM, AFM/STM, susceptibility and resistivity. - Processing and fabrication of HTS multilayer device structures by ultra-violet-photolithography with submicron resolution and ion beam etching. - Development of readout electronics for APF. - Measurements of basic properties of APF enhanced HTS SQUID device structures such as energy resolution, noise properties, bandwidth and dynamic range. - Implementation the SQUID sensor and readout electronic in a SQUID microscopes for biomagnetic applications. The main benefit will be to obtain a global scope in the sensor fabrication . Links with industry / industrial relevance (22) Industrial relevance: Ongoing collaboration with Oxford Instruments (Cambridge Science Park)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Thermochemical conversion of solid fuels - processes of pyrolysis, gasification and combustion of biomass and wastes' to be submitted under Fifth Framework.

assistant: **Abstract**

The measures in this project allow the Centre for Thermochemical Conversion of Solid Fuels" to strengthen its position on the European level, integrating its activities in the European Research Area in the field of research on thermochemical processing (pyrolysis, gasification, combustion) of renewable energy sources (biomass) and wastes. Through this project the Centre can validate its strong position on the national level and in Central Europe, supported by the network and service system established in the project. For what concerns the further development of the international network, the key-partners of the Centre are expected to continue co-operation with the Centre in the after-project period, particularly in the projects of 6FP. The project activities will help the Centre to disseminate best practises within the Poland and other NAS countries, and promote usage of new biomass processing technologies for heat and power generation."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Identification of novel genes potentially involved in hindbrain segmentation'.

assistant: **Objectives**

Research objectives and content This project is designed to identify novel mouse genes expressed in a segment-specific manner in developing hindbrain, without any presupposition on their identity. We will take advantage of the existence of mice carrying a null mutation in the gene Krox-20, which results in an elimination of rhombomeres number 3 and 5. We will apply the procedure of Differential RNA Display to this very clean genetic system, which should allow the identification of genes specifically expressed in the segments affected by the mutation. In practice, we have already performed preliminary experiments which have led to the cloning of several sequences which are amplified with wild type RNA but not with mutant RNA. We will continue this analysis to accumulate additional candidate clones. These will then be used in whole mount in situ hybridisation experiments to establish whether their expression is indeed restricted to rhombomeres 3 or 5 during hindbrain development. The positive clones will be sequenced and, if they correspond to novel genes, they will be used to isolate complete cDNAs in order to initiate their functional analysis. Particular efforts will be put on genes encoding adhesion molecules, if such genes are revelad by this work. Training content (objective, benefit and expected impact) The morphogenesis of the vertebrate hindbrain is subjected to a segmentation process which sets essential aspects of its neuronal architecture. To have access to the molecular mechanisms governing this phenomenon, it is essential to identify the genes which play a role in its control. It is expected that many of these will be expressed in a segment-specific manner. Indeed a few genes with such an expression pattern have been identified, either by accident or by syst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Neanderthal and Modern Human Adaptations in Eastern Europe' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Modern human dispersal into Eurasia and the replacement of Neanderthals is one of the major issues in archaeological research. Particularly interesting is that modern humans were extremely successful in dispersing from Africa into virtually all parts of the planet. What behavioural adaptations contributed to their success? Are these adaptations unique to modern humans? What were the climatic conditions under which modern humans dispersed into Europe? Answering these key questions requires comparing the behaviour of the last Neanderthals and first modern humans in Europe, and placing these behaviours in an accurate climatic context. There is an urgent need for new, high quality datasets as much of the current debate deals with biased datasets from old excavations. Therefore, it is proposed here to survey and excavate new sites in four case-study regions in Eastern Europe (Ukraine and Russia). This project has two objectives: (1) the empirical creation of new scientific information and (2) the testing of models of modern human-Neanderthal interaction, modern human dispersal and colonisation processes. Objective 1 includes (a) characterisation of Neanderthal and modern human behavioural and cultural adaptations in the four case-study areas, (b) construction of a chronostratigraphic framework for the Late Middle and Early Upper Palaeolithic of these areas, and (c) reconstruction of palaeoclimate and palaeoenvironment to assess the conditions under which modern humans dispersed into Europe. Objective 2 seeks to test hypotheses and theoretical models of modern human-Neanderthal dynamics against these new data using a systematic, deductive approach. This project will contribute to a better understanding of the chronostratigraphic and climatic context of the modern human disper
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cavitation bubble cloud dynamics and surface erosion in high pressure fuel systems for medium/heavy duty Diesel engines' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The medium/heavy duty Diesel engine industry is facing new challenges for meeting the forthcoming emission regulations. Injection pressure reaching 3000bar combined with multiple injection strategies can drastically reduce the NOx/PM trade-off and allow use of less demanding aftertreatment systems for meeting the set legislations. At the same time, use of commercial Diesel engines is expected to double over the next few decades. Cavitation erosion can affect the durability of the injection system to levels that replacement of mechanical parts only after hours of operation is demanded. The proposed programme will assist in the understanding of such flow effects using thoroughly validated CFD models and assisted by detailed experimental data as well as industrial input. The fundamental process that will be thoroughly investigated is the collapse of cavitation bubble cloud and the erosion it induces on solid surfaces. This expertise has been developed at the outgoing host institution, NTU in Singapore where the applicant will develop and validate a simulation model for such effects. Upon return back to Europe, the numerical model will be implemented into the CFD code of the return host and which simulates the macroscopic cavitating flow development within fuel injection systems. Under the premises of the International Institute of Cavitation Research, the applicant will consider with the new model effects not captured so far but believed to be of imperative importance: the prediction of cavitation surface erosion caused by sudden bubble collapse at pressure up to 3000bar and temperatures reaching locally more than 450oC. This excessive heating is produced during the fast acceleration of the fuel as it flows through the injection holes and can result to flow boiling. Thus,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Pollinator-assisted plant natural selection and breeding under climate change pressure' to be submitted under Horizon Europe.

assistant: **Abstract**

Food security is threatened by climate change, with heat and drought being the main stresses affecting crop physiology and ecosystem services, such as plant-pollinator interactions. Despite the increasing relevance of flowers in sensing the stress, phenotyping platforms aim at identifying genetic traits of resilience by assessing the physiological status of the plants, usually through remote sensing-assisted vegetative indexes, but find strong bottlenecks in quantifying flower traits and in accurate genotype-to-phenotype prediction. However, as the transport of photoassimilates from leaves (sources) to flowers (sinks) is reduced in low-resilient plants, flowers are better indicators than leaves of plant well-being. Indeed, the chemical composition of flowers changes in response to heat and drought, as it does the amount of pollen and nectar that flowers produce, which ultimately serve as food recourses for the pollinators. DARkWIN proposes to track and rank pollinators’ preferences for flowers of a tomato mapping population exposed to heat and drought as a measure of functional source-to-sink relationships. To achieve this goal, DARkWIN will develop a pollinator-assisted selection and phenotyping platform for automated quantification of Genotype x Pollinator x Environment interactions through a bumblebee geo-positioning system. Pollinator-assisted selection for agriculture will be validated by a multi-omics dataset of unprecedented dimensions in a mapping population of tomato, including floral metabolic, transcriptomic, and ionomic traits, as well as mapping candidate genes, linking floral traits, pollinator preferences, and plant resilience. Moreover, DARkWIN will deliver tomato F1 pre-commercial varieties based on the natural biological process of pollinatordriven sel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design and evaluation of an oligonucleotide microarray for the detection of signature microorganisms in composts from anaerobic digestion of biowastes' in the context of a Sixth Framework call.

assistant: **Objectives**

The European Community produces every year 200 million tonnes of biodegradable wastes, which have to be diverted from land-filling according to European laws. Biological digestion, either aerobic or anaerobic, is the most environmentally favourable option f or the recycling of biowastes. Composts resulting from these processes are used as soil improvers, which, among other benefits, exert plant disease supressiveness due to the presence of microorganisms that are antagonists to pathogens. However, improperly treated composts may spread pathogenic microorganisms, thus damaging the environment and posing risks to human health. This causes concern among the general public, especially after the food alerts during the last decade, and constitutes a priority issue within the European Research Area.Therefore, a tool that allows the quick analysis of compost microbiota is needed to safeguarde its agronomic value. DNA biochip technology offers the possibility to simultaneously detect an entire array of micro-organisms. The host group has recently designed a micro-array addressed towards compost microbiota. This proposal aims to design an oligonucleotide micro-array to detect signature microorganisms in composts from anaerobic digestion. Micro-organisms that will be isolated from compost will be targeted. Additional probes will be selected on basis of sequences determined from bands in DGGE gels run with compost DNA. Oligonucleotide probes will be designed using sequence differences in the 16S rDNA gene and printed onto the arrays.Fluorescently labelled DNA will be prepared and hybridised, and the arrays analysed by fluorescent screening. The validation of the micro-array will be mainly conducted through spiking experiments and through their wide application to already characteri