RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An Integrated Peptide and Foldamer Chemistry Approach Towards Pro-apoptotic TRAIL Mimetics' (FOLDAPOP).

assistant: **Innovation**

Death Receptors (DR), members of the tumour necrosis factor (TNF) receptor family, have come into focus as suitable targets for the selective activation of the cell death (apoptosis) pathway in tumours in vivo without causing toxicity to healthy cells. Current approaches in clinical development for replicating the function of the TNF-related apoptosis inducing ligand (TRAIL) are restricted to recombinant proteins which have poor pharmacokinetic properties due to their susceptibility to proteolytic degradation, and high production cost. In this context, the identification of small molecules that can both bind to TRAIL receptors (eg. DR5) and activate the TRAIL pathway is of prime interest towards the development of new treatments complementary to conventional cancer therapy. The aim of this project is to develop foldamers (unnatural oligomers with predictable conformations) as proapoptotic DR ligands (e.g. TRAIL mimetics) by capitalizing on recent achievements of the host group in the fields of peptide and foldamer chemistry. The research plan involves the following specific objectives: 1) exploration of structural requirements for peptide-binding to DR5, 2) evaluation of foldameric systems for polyvalent display, 3) structure-guided design of DR5-binding helical foldamers and 4) construction and screening of focused foldamer libraries for binding to DRs. The applicant has experience in the synthesis of unnatural, constrained amino-acid synthesis for exploration of bioactive peptide conformations. She will join and bring her expertise to a host laboratory in France specialized in the synthesis and characterization of foldamers. Collaboration between the host and established European groups with prominent expertise in the biology of DRs and combinatorial chemistry has bee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Dioxin and pcb accumulation in farmed fish from feed' (DAPAFF) targeting Fifth Framework.

assistant: **Abstract**

OBJECTIVES AND EXPECTED ACHIEVEMENTSIn view of the concern of reducing the level of dioxin in the food chain, focus has been placed on levels found in animal feed and those transferred to human food. Particular interest has focused on fish as a vehicle which can carry high loads of dioxin picked up from the natural environment in which the fish is living.The purpose of this research is to examine the uptake of dioxin by fanned salmon from salmon feed during the growth of the salmon from 1.3kg to approximate 4kg market weight. Four salmon feeds with graded levels of dioxin prepared using mainly fish meal and fish oil; the latter are of high or low dioxin concentrations and different blends are to be tested. Dioxin, PCBs and heavy metals (contaminant) levels will be determined in the feed and in the salmon after 15 weeks and 37 weeks feeding experiments when the fish will have reached approximately 2kg and 4kg in weight.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Carbon nanotubes for future industrial composites: theoretical potential versus immediate application'.

assistant: **Innovation**

Nanotechnology is expected to lead to high-strength, lightweight polymer nanocomposites because of the properties evident in nanoscale reinforcing elements. Using carbon nanotubes (CNTs) and carbon nanofibres (CNFs) as filler materials will introduce electrical conductivity to polymers coupled with an increase in mechanical performance. The proposed Thematic network fiCNT-Netfl co ordinates research activities presently conducted at the participating research centres and industrial partners on CNT / CNF-related projects. The network combines international areas of competence with a group of companies with high technological expertise. The thirteen leading European partners envisage the transfer from fundamental science to cost-effective production of polymer nanocomposites with improved properties and significant positive environmental impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Geometric and Numerical Analysis of Dynamical Control Systems' under Horizon Europe.

assistant: **Concept**

This multidisciplinary project bridges differential geometry, optimal control, and numerical analysis, with practical applications in robotic engineering. It introduces a novel approach to path-planning for dynamical control systems on Riemannian manifolds, simplifying many challenges of modern geometric control methods. The central hypothesis is that, under certain conditions, control forces can be integrated into the geometry of the configuration manifold, enabling the trajectories of double-integrator systems to be interpreted as Riemannian geodesics of a modified Riemannian metric. By introducing Gordonian and conformal transformations, the metric is strategically modified to achieve objectives such as trajectory-tracking and obstacle and region avoidance. B-stable modifications of the implicit geodesic Euler method and symplectic geodesic Euler method are constructed on Riemannian manifolds by strategically modifying the curvature through Gordonian transformations. Applications considered throughout the project include the design of trajectory-tracking control schemes for teams of quadrotor UAVs transporting cargo, as well as region avoidance on Riemannian homogeneous spaces.


**Keywords:** geometric control, Riemannian geometry, geometric integration, optimal control
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Biochemical and genetic approaches to study bio-molecular interactions in plants'.

assistant: **Concept**

This training network addresses the secretory pathway in plants with a special focus on proteins, their interactions with each other and other biomolecules, and the potential of this pathway for biotechnology. The network partners provide non-overlapping expertise in methods to elucidate bio-molecular interactions, ranging from genetic approaches via co-localisation to specific protein-protein interactions using the most advanced protocols. The aims are1) to understand receptor function and signal transduction controlling protein sorting and vesicle transport,2) the identification of novel sorting receptors and sorting mechanisms that are likely to be unique to the plant kingdom,3) the molecular characterisation of interactions between chaperones and their ligands.4) To study a group of products of the secretory pathway within a set of specific model system, elucidate their step-wise biosynthesis and transport, and the way in which manipulation of: the pathway is possible to redirect these molecules or to prevent turnover.5) The predicted spin-off from this work will firstly contribute to the fundamental insight into the secretory pathway of plants and, secondly, help to evaluate the potential of the secretory pathway for directed pathway engineering in order to maximise productivity in plants of heterologous proteins with high added value, such as human serum proteins, antibodies, or vaccines.Within the framework of this research programme, we aim to set the stage for contained plant fermentations in bioreactors with the help of small-scale feasibility studies. We believe this programme will be instrumental in the development of high capacity and cost effective production systems combined with environmentally save procedures, which is currently an important issue to re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Assessing Needs of Care In European Nations' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The large post-war baby boom is now turning into a grandparent boom, putting a triple stress on long-term care (LTC) provisions: increased numbers of elderly, increased survival of these elderly and increased survival of frail, disabled elderly through improved care and health care. Increasing body weights, through increasing disability and care dependence among the obese, further add to numbers of disabled elderly. The supply of labour is affected by the ageing of the EU population. Consequently, increasing emphasis has been put on the future development of long-term care needs, supply and use, and the functioning of LTC systems. The objectives of ANCIEN (Assessing Needs for Care In European Nations) are to review the LTC systems in EU member states, to assess the actual and future numbers of elderly care-dependent people in selected countries and to develop a methodology for comprehensive analysis of actual and future LTC needs and provisions across European countries, including the potential role of technology and policies on maintaining and improving quality. Performance indicators will be identified and relative performances of the different types of LTC systems assessed.  Databases of EU countries are constructed, containing available data on LTC needs and use of the elderly. Participating partners from different countries cover the majority of the EU member states. State of the art demographic, epidemiologic and econometric models are used to project future needs and use of long-term care in representative member states with different LTC systems. Deliverables contain databases, dynamic models calculating long-term care needs, reports on future needs and use of LTC in representative member states, and country-specific and general reports on LTC systems and their
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how '3D Community Aware Virtual Spaces as Smart Living Environments for Physical Activity and Rehabilitation' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Multiuser immersive experiences can provide an opportunity to leverage health results and quality of life in smart ageing care environments.Virtual Reality (VR) current approaches for the Silver Economy follow a common pattern:the gamified experience.VR2Care breaks the current VR paradigm in smart living environments by enabling a multi-user mixed reality service, available for embodied exercising group in different physical locations at the same time and with expert exercise supervision.Motivation is empowered in VR2Care by a social commitment. A social experience of several people sharing difficulties and fighting isolation, replaces the “the patient/user and the application” paradigm, and the gamified entertainment experiences.VR2Care goes beyond the common requirements as it is codesigned with active participation of older adults, caregivers, therapists, community and clinicians to provide a full immersive multiuser experience.VR2Care will leverage the technology by running four demonstrators that support the project pilots in three locations across the EU:Portugal,Netherlands and Italy.Demonstrators explore the multiuser capabilities of the environment in a distance psychomotricity training with large movements; multimodal natural interaction, with real time AI supported guidance for a one-to-one physical rehabilitation experience; an hybrid approach with a local group of older adults and a distance individuals performing physical activities; and a clinical approach for the promotion of exercise as a therapy after rehabilitation.From a business perspective,VR2Care opens up a global market to deliver services and products to customers, where distances between provider and customer disappear.Business opportunities go beyond the technological and technical companies,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Planning for Sustainable Ocean Use in Antarctica Under Global Environmental Change' under Horizon Europe.

assistant: **Concept**

Planning of marine areas is being developed worldwide to support ocean sustainability. However, few existing marine spatial planning (MSP) initiatives consider climate change explicitly. This is a critical oversight in a rapidly changing world.At the same time, no formal MSP initiatives are envisioned for Antarctica; it is the only ocean basin globally without MSP under development. Antarctica is changing rapidly with potential repercussions around the planet, particularly for sea-level rise, climate regulation, and marine ecosystems functioning. Developing integrated, sustainable MSP for Antarctica is now more fundamental than ever.Excluding climate effects from MSP will lead to plans that are maladaptive and inefficient in sustaining marine ecosystems and their use under change. By contrast, if designed with climate objectives, MSP can provide substantial benefits while requiring few trade-offs. Efforts must be thus put together to effectively move towards climate-smart MSP in Antarctica and globally.Yet, contextual idiosyncrasies (political, social, economic) limit the effectiveness of such efforts. Understanding what challenges hinder the development of climate-smart MSP, in Antarctica and globally, and pointing ways to overcome such challenges is key. PLAnT will take up, for the very first time, such critical task. It will assess social-ecological vulnerabilities; build future scenarios; support area-based climate action and dynamic solutions; conduct governance analyses; and foster a paradigm shift on how to plan for sustainability and equity under change.Research on complex social-ecological systems rarely leads to one-size solutions, and there is a risk that solutions identified in PLAnT are context specific. Still, PLAnT will inspire nations worldwide to findin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Małopolska Researchers' Night 2018-2019 (European Researchers' Night in Małopolska)' under Horizon 2020.

assistant: **Concept**

The project covers two editions of the European Researchers’ Night (ERN) in Małopolska in 2018 and 2019, respectively for the 12th and 13th time in our region. The event will be held in 7 cities of the Małopolska Region (Kraków, Tarnów, Nowy Sącz, Niepołomice, Skawina, Andrychów, and Chrzanów) to show the wide scientific heritage, with access not being a barrier to the participation of the residents of various parts of the region. Researchers from participating institutions prepared approx. 1,000 different activities, a total of approx. 2,000 within the entire 2-year project. The preparation of such a diverse programme will involve approx. 4,000 people every year, both experienced researchers and beginners (students, representatives of scientific circles), as well as R&D employees from companies located within the region. In addition, due to the fact that 2018 is the European Year of Cultural Heritage, we have prepared even more attractions and surprises for this year's edition – there will also be the possibility to meet researchers in ... museums, libraries, and even in a historical church which the participants will certainly not be expecting.  The next two editions of the ERN in Małopolska focus on showing researchers as ordinary people with extraordinary job that affect our daily lives and how in practice researchers change the world. An important distinction of the ERN among other events is that we focus 100% on interactivity. During the RN, the researchers present their work combining learning with entertainment (edutainment), to make children and young people as passionate about science as possible. But the participants themselves will feel like real researchers performing unusual experiments under the watchful eye of their mentors. The project has European dime
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A multilinear approach to the restriction problem with applications to geometric measure theory, the Schrödinger equation and inverse problems'.

assistant: **Concept**

The Fourier restriction conjecture, one of main open problems in harmonic analysis, has deep connections with problems in a variety of different fields of mathematics. The aim of this proposal is to further develop the multilinear approach in restriction theory and apply it to several problems in geometric measure theory, the Schrödinger equation and inverse problems. In order to develop this proposal, the Experienced Researcher will join the harmonic analysis group at ICMAT under the supervision of one of its permanent researchers, Keith Rogers, an ERC grant awardee. The host group has extensive experience in the application of harmonic analysis techniques to inverse problems and geometric measure theory, among others. The scientific training strategy of this proposal consists in the assimilation of the techniques of geometric measure theory and inverse problems. While the Researcher is experienced in restriction theory and dispersive equations, as evidenced by his contributions to the field, it is the combination of this prior knowledge with the proposed scientific training that is needed for the successful development of this proposal.This MSC fellowship will achieve a variety of positive outcomes: boosting the convergence of distinct research fields and collaborative networks, producing a synergy with the ERC Starting Grant recently held by the Supervisor, and diversifying the fellow’s mathematical knowledge, ultimately strengthening him as an independent researcher.


**Keywords:** Fourier restriction, Kakeya problem, geometric measure theory, inverse problems, Schrödinger equation, Carleson problem, Falconer problem, Calderón problem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A sub-percent distance scale from binaries and Cepheids' (CepBin), addressing dissemination and exploitation.

assistant: **Impact**

We propose to carry out a project which will produce a decisive step towards improving the accuracy of the Hubble constant as determined from the Cepheid-SN Ia method to 1%, by using 28 extremely rare eclipsing binary systems in the LMC which offer the potential to determine their distances to 1%. To achieve this accuracy we will reduce the main error in the binary method by interferometric angular diameter measurements of a sample of red clump stars which resemble the stars in our binary systems. We will check on our calibration with similar binary systems close enough to determine their orbits from interferometry. We already showed the feasibility of our method which yielded the best-ever distance determination to the LMC of 2.2% from 8 such binary systems. With 28 systems and the improved angular diameter calibration we will push the LMC distance uncertainty down to 1% which will allow to set the zero point of the Cepheid PL relation with the same accuracy using the large available LMC Cepheid sample. We will determine the metallicity effect on Cepheid luminosities by a) determining a 2% distance to the more metal-poor SMC with our binary method, and by b) measuring the distances to LMC and SMC with an improved Baade-Wesselink (BW) method. We will achieve this improvement by analyzing 9 unique Cepheids in eclipsing binaries in the LMC our group has discovered which allow factor- of-ten improvements in the determination of all basic physical parameters of Cepheids. These studies will also increase our confidence in the Cepheid-based H0 determination. Our project bears strong synergy to the Gaia mission by providing the best checks on possible systematic uncertainties on Gaia parallaxes with 200 binary systems whose distances we will measure to 1-2%. We will provide tw