RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Polyclonal anti-tumor immunity by engineered human T cells' in the context of a Horizon Europe call.

assistant: **Objectives**

Adoptive T cell therapies are a new class of living drugs, achieving durable results in a subset of patients with aggressive malignancies. These transformative outcomes are not shared with the majority of patients with solid tumors that remain resistant to current T cell therapies. As engineered T cell therapy is usually directed against a single antigen, it is especially vulnerable to antigen loss as a tumor resistance mechanism. Moreover, cancer immunotherapy often leads to severe immune-related adverse events (irAE) by destructive self-reactivity that must be evaluated together with the therapeutic benefit. While T cell therapies with tumor-infiltrating lymphocytes might circumvent these shortcomings, tumor tissue availability is limited and T cells are poorly responsive to ex-vivo perturbation. These therapeutic challenges highlight the gaps in our knowledge of how to engineer curative anti-tumor immunity. We recently developed foundational platforms for CRISPR engineering, TCR repertoire manipulation, and single-cell omics of primary human T cells. We plan to leverage these opportune achievements to address the critical gaps in adoptive T cell therapies. We will focus on three important aspects of engineered anti-tumor immunity: efficacy, safety, and specificity. We will tune TCR sensitivity by perturbing key genes to determine how TCR signaling balances burst-like effector function and long-term persistence. We will also reveal the sequestered self-reactive T cell compartment to control for irAE following immunotherapy. Finally, we will directly uncouple anti-tumor TCR repertoires from their dysfunctional state to mount a polyclonal anti-tumor immune response. This strategy is radically different from current T cell therapies as it is agnostic to specific tumor an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Aphasia' in the context of a Fifth Framework call.

assistant: **Objectives**

Historically, the benefits of aphasia therapy have been controversial based on largely anecdotal accounts. Views on the value of therapy to treat aphasia have fluctuated over the years. More recently, changes in our society have dictated the need for scientific evidence describing the nature course, and time of recovery in aphasia and how intervention can facilitate it. Increased advances in technology and the development of brain imaging techniques have provided greater insights into the patterns of recovery and how therapy can enhance it.However, we still lack a widely accepted scientific approach in describing the nature of aphasia and aphasia therapy. Current changes at the socio-economic dynamics of health care delivery in different countries have resulted in a wide variability of methods of delivery of therapy to aphasic patients. This has not only implication for the individual, but also for the socio-economic climate of the community that he lives and functions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interactive Research in Music as Sound:Transforming Digital Musicology' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In an age when technology is revolutionizing the ways in which music is made and distributed, this project proposes correspondingly to transform approaches to musicology, moving from a primarily fixed, text-based approach to one that incorporates as an integral feature the interactive and aural. It brings skills and expertise from music technology to assist in the development of research strategies and software to enable musicological research to engage more directly with sound. It will pioneer a ground-breaking approach to music research in which dynamic interaction with sound is fundamental and music’s temporal and transient nature are central to research investigations and their dissemination, presenting a significant conceptual challenge to the traditional textual bias of much musical research and leading to new enhanced modes of musicological knowledge. Unlike current Digital Musicology, rather than using software primarily to extract quantized data, IRiMaS facilitates research through dynamic interactive engagement with sound.The interactive approach will be developed in the context of three Case Studies in specific areas where prioritizing the aural is of particular significance. The Case Studies will focus on Spectralism in the field of Contemporary ‘Art’ Music; Tracking the Creative Process in Free Improvisation; and Folk Songs in Performance in the field of Ethnomusicology. Each study will produce substantial ground-breaking musicological outcomes in the form of software packages (as is appropriate to the nature of the project) and associated articles discussing the approach taken. They will also assist in working towards the development of models and generic tools to help establish the wider adoption of this interactive approach. Building on the PI's previous
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Unprecedented photolithographic structuring of novel light-sensitive poly(amino acid) materials– a paradigm shift in delivering biocompatible devices' (POLINA) targeting Horizon Europe.

assistant: **Abstract**

Photolitography, which produces geometrical structures through light-induced polymerisation of monomers with high accuracy, precision and spatial resolution, was a key innovation enabler in the drive for high-performance miniature electronics, which had an unprecedented impact on every aspect of our modern life. Geometrically well-defined microstructures could also be a game changer in the medical device industry, especially in the development of implantable devices with better tissue compatibility, as well as in the discovery of new drugs and treatments. Current gold standard materials and biomaterial extrusion processing cannot generate the structural resolution to kick-start this new era. The groundbreaking approach of POLINA is to combine a radically new, light-sensitive poly(amino acid) material platform with established and emerging photolithographic patterning techniques to deliver a revolutionary technology that can be exploited for medical devices and next-generation green electronics. Exploring this uncharted territory will be possible through an ambitious multidisciplinary approach delivering breakthroughs in photopolymerisation of amino acids and their lithographic structuring for novel materials with unique biological properties. The high innovation potential of this technology to overcome current limitations will be demonstrated in three selected examples related to lung diseases, i.e., micropatterned cell surface models, spheroid arrays for lung disease modelling and drug testing as well as tracheal implants. Our intersectoral team of 5 academic groups and 2 SMEs brings together unique scientific expertise in photo and polymer chemistry, biomaterials science, lithographic processing, tissue engineering, clinical expertise and innovation management. Throug
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Semantic-enabled agile knowledge-based e-Government'.

assistant: **Objectives**

Permanent changes in the environment (political, economical and ecological) cause frequent changes in the governments regulations that may affect public administration (PA) processes and systems. To reduce time-to-market with regards to new decisions, regulations, and law, it is necessary to equip public administration with tools supporting the agile response to changes. A change in one activity in a process or in one part of an e-government system (front and back office) may cause many problems in other parts of the same process or system.Therefore, there is a need for resolving changes in a systematic manner, ensuring overall consistency. Furthermore, these changes impose the need for updating the knowledge needed to perform the administrative process or use the e-government system, which is heterogeneous and fragmented. These needs are more prominent in the case of New Member States, since their full integration heavily depends on the possibility to adapt their public administrations to the existing EU regulations in a very short period of time.The SAKE project addresses the afore-mentioned needs by specifying, developing and deploying a holistic framework and supporting tools for an agile knowledge-based e-government that will be sufficiently flexible to adapt to changing and diverse environments and needs. The proposed SAKE solution will comprise:- a semantic-based change management system,- semantic-based content management system,- a semantic-based groupware system.The SAKE project brings together a well-balanced mixture of ten partners, that each one brings into the project a different focus of work and a different perspective of emphasis. It should be noted that the majority of the partners are coming from New Member States (i.e. Hungary, Poland and Slovakia).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Tackling Water Challenges in the International Context' (IC4WATER).

assistant: **Concept**

The Joint Programming Initiative Water Challenges for a Changing World, the Water JPI, is an intergovernmental initiative which strives to achieve sustainable water systems for a sustainable economy in Europe and abroad.IC4WATER’s objectives include supporting agencies in stepping up international cooperation: through the sharing of best practices, networking, closer coordination of existing activities, and the establishment of new relationships to facilitate multidisciplinary networking across the water challenges at a wider scale, both with respect to research and geographical areas. A mapping of the existing research cooperation models (mainly bilateral – between a Member State or the European Commission and some Beyond Europe countries) and a comparative analysis of existing cooperation models will be issued to identify barriers and challenges to transnational collaboration, and formulate successful mechanisms for working together efficiently beyond this bilateral approach.In order to become more than a ‘network of networks’ and a dialogue platform for research programmes and to bring genuine added value to the current cooperation models, IC4WATER will be focusing on key topics of the Water JPI Strategic Research & Innovation Agenda. As an initial focus, the Water JPI Governing Board, which endorsed the IC4Water concept in November 2015, has agreed a plan to pilot new principles of international transnational cooperation through concrete joint programming, focusing on the theme of UN Sustainable Development Goals related to Water challenges. A shortlist of key ‘UN SDG thematic’ RDI areas will be scoped in more detail and will serve as recommendations for joint activities (opportunities for cooperation with funding RDI governmental institutions or for RDI support for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'PEPTICHIP: Streamlined identification of tumour neoantigens for personalised anti-cancer immunotherapy'.

assistant: **Concept**

Immunotherapeutic strategies have emerged as powerful tools to treat many types of cancers. However, the majority of patients still fails to respond to immunotherapies as targetable tumour characteristics vary from patient to patient. Thus, a greater degree of personalisation is required to fine-tune immunotherapies to the specific vulnerabilities of each patient’s tumour. While therapies that target tumour-specific antigens (neoantigens) invoke a strong and specific anti-tumour immune response, we are currently unable to accurately identify patient-specific neoantigens. Current neoantigen identification and purification methods either require impractically large quantities of tumour material or are laborious, expensive, time-consuming (weeks or months) and inaccurate.   As part of ERC project PEPTICRAD (2016-2021), Prof. Vincenzo  Cerullo at the University of Helsinki has developed a novel microfluidic chip-based device (PeptiCHIP) which condenses the neoantigen purification steps into a single chip capable of accurately analysing minute quantities of human tumour tissue. PeptiCHIP permits cost-effective, rapid, sample-conserving, user-friendly, accurate and standardised tumour neoantigen identification, thereby unleashing the full potential of personalised anti-tumour immunotherapies.   In this ERC PoC project, a team of technological and commercial experts will ascertain the technical and commercial viability of the innovative PeptiCHIP device. We will prepare the first steps toward the start-up of a spin-off by defining the most optimal business strategy and model. Furthermore, we will explore the technical potential of the PeptiCHIP and solidify our IP-position. We will develop a solid business strategy based on the technological aspects, the market needs and trend
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Technological innovation on textile dyeing using liposomes' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Liposomes are self-assembling vesicle structures formed by biological lipids. The intrinsic vehicle capacity of liposomes has been proved by some scientific experiments at laboratory level concerning both the vehiculization of dyes and the subsequent application onto wool during the dyeing process. In this project, we try to confirm at industrial level the technological possibilities of this new strategy in order to transport some dyes (acid and pre-metallized) from the bath to the fibre. Some different industrial conditions (type of liposome, several dyestuffs, temperature and periods of time during the dyeing process, etc.) will be explored and compared with conventional dyeing conditions.. The most appropriate process will be optimized according to the values obtained on chemical and mechanical properties of the samples dyed. By this innovative approach we expect to maintain acceptable quality standards for the fibres used (mainly wool and acrylic/wool blends) but saving energy/time of the process, avoiding the use of conventional synthetic auxiliaries and reducing additionally the environmental impact of the dyeing processes in the textile field.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Non-toxic antifouling for leisure boats' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The growth of marine fouling (e.g. barnacles, algae etc.) on boat hulls presents a serious problem for boat owners. It increases friction and drag of a moving boat, reduces speed, causes higher fuel consumption and generally raises ownership costs. Effective antifouling coatings containing copper and biocides have now shown harmful to the marine environment and an EU-wide ban of such chemicals is expected. For merchant ships, alternative antifouling solutions exist, which unfortunately is not suited for low speed pleasure boats. That leaves leisure boat owners without an effective non-toxic product to combat fouling. Extensive research in Europe has not yet resulted in mass production of commercial products with a quality comparable to the toxic paints. Lack of strong ties between research institutions and the end users is a main reason for such failure. To resolve the problem, Lotréc, an experienced marine coatings manufacturer will lead a consortium, which will provide the missing link.The consortium's joint efforts will satisfy the company's need for external expertise and advanced test equipment, improve cooperation between regional specialists and as a result bring European countries closer to creating optimised test protocols for marine coatings. The main goal of the project is to bring an effective and accessible product to European leisure boat owners. The aim is to create antifouling coatings where substances poisonous to fauna can be substituted with environmentally safe but efficient components.The goal will be achieved through:Extensive research of surface micro-topographies potentially unfriendly to fouling ·Development of tools adjustable to surrounding water conditions to control the release of antifouling componentsEvaluation of the possibility to combin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Virtual testing for extended vehicle passive safety'.

assistant: **Concept**

In this project, the virtual testing process for crash safety applications will be defined in three work packages. In WP1, procedures and guidelines will be defined to apply virtual testing as part of regulated passive safety evaluations. In WP2, the stochastic response of crash tests caused by the scatter in the components will be modelled. In particular, the variability of regulated crash dummies will be evaluated to indicate areas where the current regulated dummy responses are insufficiently reproducible. In WP3, the range of protection will be extended to real life crash conditions by identification of gaps in the current regulations where occupants are not being adequately protected. Based on an extensive analysis of the effects of impact conditions and occupant characteristics, procedures will be defined to fill these gaps by virtual testing.1)A general procedure for objective rating of comparisons between numerical and experimental results (including software);2) General modelling and validation procedures for numerical dummy models, human models, restraint system models, barrier and vehicle models;3) Evaluation of machine and software dependencies;4) General modelling guidelines for impact simulations. Assessment of accuracy and reliability that can be obtained by virtual testing and of possible reductions in hardware testing and design costs;5) An overall injury risk assessment method for a range of impact conditions and injury criteria (including software);6) Indication of areas where the current regulations are not optimally protecting car occupants;7) Assessment of the potential of real human models for passive safety design;8) A validated virtual test procedure extending the range of protection beyond current regulations to real life crash conditions;9) A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Demonstration of a low nox fuel-staged combustor in a high efficiency gas turbine target action F: gas power generation' (FUELCHIEF).

assistant: **Concept**

The overall objective of the project is to design, construct and test the concept of a fuel-staged combustor, to demonstrate a major enhancement of current lean premix technology. This is required as an enabling technology for high efficiency (>60%), flexible, CCGT to overcome the problems of combustion induced thermoacoustic pressure pulsations.The specific objectives of the project are to demonstrate:- Base load NOx emissions of below 10ppmv firing natural gas and below 25ppmv firing liquid fuels such as distillate oil at full engine operating conditions.- Thermoacoustic pressure pulsations of less than 0.3% of total operating pressure over the full engine load range- Simplification of the engine commissioning procedure- Elimination of fuel line purging- Easy adjustment of the fuel-staged combustion system to different ambient conditions and engine operating requirements