RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Transneuronal tracing reveals the modular building blocks of the nervous system' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

The functioning of entire neuronal assemblies is one of the foremost interests of current research that forms the leading edge in today's neuroscience, imaging technique, computer sciences and robotics. Although neuronal network theories introduce algorithms that are thought to resemble actual nervous system operations, functional mechanisms of such neuronal nets are still elusive, largely because of a lack of knowledge about connectivity of all involved nervous structures. This information can now be provided by a new transneuronal tracing technology with rabies virus, which was developed in Europe. This technology offers for the first time the opportunity to describe functionally related neuronal networks in their entirety, i.e., the hierarchy of their building blocks, accessory elements and parallel processing characteristics. The proposed project will represent the first large-scale application of this technology to the study of the primate brain, for which the eye movement network was selected as a model system. Aside from its importance in daily life, this system has the advantage that some of its elements are already well described, constituting established sub-systems. At the same time, clarification is needed concerning higher order processing (e.g., cortical areas) and cell communication within and between the various sub-systems. The oculomotor system is also an excellent example of the modern concept of modular organization of central nervous operations. Such spatial modules exist in the spatial orientation planes of the three pairs of extra-ocular muscles. These form a natural reference frame that is reflected in the structure and function of the underlying neuronal circuits. Viral transneuronal tracing from two prototypical eye muscles, one horizontal (lat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INNOVATIVE APPLICATION OF CO-GENERATION FOR HEAT AND ELECTRICITY PRODUCTION IN THE LARISSA UNIVERSITY HOSPITAL [PHASE 1]', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The aim is to demonstrate the best way to use natural gas in order to cogenerate heat and eletricity for the needs of Larissa University hospital. Heat is cogenerated with 4 gas engines, each 650 kWe. The innovative aspects lie in the use of gas in Greece. It is expected to use latest design of systems in the construction of the plant for example high efficiency, low NOx emissions, NOx catalysator, superheated water, low noise level, computer control etc.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Subsurface Precision detection of Asparagus with Robot Technology for Selective harvesting' (SPARTerS) under Horizon 2020.

assistant: **Objectives**

Harvesting of white asparagus is still performed manually due to the absence of cost-effective harvesting technology. To date, there are no harvesting machines available, to realise economically viable harvesting cost reduction. Next to undesired working conditions, manual harvesting is characterised by high harvesting cost: 50% labour costs, 30% yield loss and 25% low quality asparagus. Cerescon has developed an automated harvesting technology for white asparagus. This will result in a 50% harvesting cost reduction, 20% increase in yield and 20% increase in production of top class asparagus. Three patented technologies are key: subsurface asparagus detection, a precise cutting mechanism and high processing. This results in 50% harvesting cost reductions and significant reduced losses (from 30 to 5%). The Wageningen University and Research (WUR) conducted a successful technical evaluation and validation of our technology.We now need to scale-up and improve our current prototype to the final setup with all functions while realizing 20% overall cost price reduction. Three important steps form this project: 1) scale up Sparter to have a 3-row configuration, 2) realize cost price reduction of core modules and, 3) demonstrate the reliability, robustness and verify yield and quality increase during two full asparagus harvesting seasons.The user needs have been defined by the Cerescon User Group. The last two years, eight leading asparagus farmers from the Netherlands, Germany and Spain have provided us with their challenges, industry knowledge, application know how and their requirements. They have all signed a Letter of Intent and are the first customers.Our commercialisation strategy focuses on European asparagus farmers (€900 million market) who suffer from a harvesting co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'LOW-COST, HAND-HELD, AND NON-INVASIVE OPTICAL SENSOR FOR MULTIPARAMETRIC FIELD ANALYSIS OF GRAPES AND LEAVES IN VINEYARDS' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In August 2009 was fully implemented the reform of the Common Market Organization for wine (CR Nº479/2008, 29-04-2008). It aims at reducing the 24 million hl/year surplus of basic low quality wine, phasing out the €500 million/year spent on wine disposal subsidies and making EU wine more competitive. This reform, together with other market constraints will endanger all EU winegrowing SMEs. To survive, they will have to increase crop value, reduce the production of basic wine and convert part into premium quality. This can be achieved by implementing new and more effective field control methods. PREMIVM proposes a low-cost, handheld device capable of non-invasively estimating ripeness and vigour parameters for grapes and vine plants. All this in the vineyard, by means of the innovative use of chlorophyll fluorescence and reflectance multispectral data correlated by specific mathematical models, with GPS tags for all readings. The device will provide data to precisely control the field, and increase production value up to 25% (expected yearly €5.000-10.000/ha income increase for winegrowing SMEs like PEREZ, QMF and PERACCIO). With a cost of €2500/ unit, consortium manufacture and distribution SMEs PSI and AGRI estimate, through a joint-venture, to reach at least 2% of the market in 5 years. This is equivalent to an expected income of €70 million, with a €30 million profit and a ROI of 0.86. The consortium provides the complementary business capabilities, commercial networks and research expertise to guarantee the technology a quick route to the market. All members are fully committed to ensuring the success of the project, led by the SMEs in testing, validating, using and protecting the results outsourced to the necessary expertise in Chl-F&R, optical instrumentation, bot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The molecular basis for actin cytoskeleton regulation by functional protein modules' (2002-2006).

assistant: **Concept**

Actin cytoskeleton dynamics is the fundamental principle underlying diverse cellular processes such as muscle contraction, embryonic development and wound healing.Our long-term goals are- to understand how dynamic stability of the actin cytoskeleton is maintained,- how actin-based machineries control cell functions such as podosome formation and phagocytosis and- what role actin-dependent processes play in pathological situations such as tumour metastasis and vascular injury.Our research aims at understanding factors which associate directly with the actin filament and which are responsible for the modulation and stabilization of actin assemblies at the molecular and cellular level. One such factor, the actin-binding protein calponin (CaP) has been identified in a 17-gene signature profile of metastasising tumours.We will investigate the molecular basis for the function of CaP in this profile, and establish the potential correlation between reduced CaP levels, the formation of podosomes and the induction of metastasis. Actin cytoskeleton remodelling during receptor-mediated phagocytosis provides the structural basis for the engulfment of particles.We plan to characterise the composition of the multi-molecular complex(es) involved, and to analyse the functions of individual components, particularly focusing on the interactions of the adaptor protein Fyb/SLAP and of its domains.Protein linguistics predicts that compositional semantics work in biological systems, as much as they do in human languages. We plan to address the conceptual problem underlying the evolution of functional diversity in cytoskeletal proteins, focusing on molecules regulating actin structure, stability and dynamics.Employing the calponin-homology domain as a model tool, we will investigate the effect
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reductive Coupling Reactions via Polar / Radical Crossover' in the context of a Horizon Europe call.

assistant: **Objectives**

This fellowship project aims to establish a new suite of photocatalytic reductive coupling methodologies using feedstock starting materials that will allow the efficient synthesis of important value-added compounds. Key to this proposal is the design and development of a reductive photocatalytic system comprising a suitable organic reductant and a photocatalyst that upon photoexcitation becomes simultaneously strongly Brønsted acidic and strongly reducing. Under appropriate reaction conditions the novel photon-controlled acidity would catalyse alcohol dehydration and concomitant single electron transfer (SET) to the arising carbocation would generate the free-radical capable of undergoing a broad range of synthetically useful intermolecular and intramolecular carbon-carbon bond forming processes The chemistry is particularly suited for generating fully substituted carbon atoms in a process where only water is the by-product. Based on these results, a new strategy for the synthesis of bioactive complex (alkaloid) natural products will also be developed. We anticipate that further advancement of these findings will revolutionize the synthesis of complex bioactive molecules using feedstock starting materials, and more broadly influence the way chemists design and access such intricate motifs.The POLARCROSS fellowship offers a high-quality and cutting-edge research platform that will enhance the state-of-the-art in European Commission funded research and will complement Dr. Wang's existing skills set. This fellowship will serve as a catalyst for enhancing the competencies needed to realize his career aspiration of securing an academic position at a top-tier institution and embarking on an independent research journey. Furthermore, it will nurture him into a seasoned, versat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Metal-Induced Energy Transfer based Electrometry and Nanometry: Dissecting Electrostatic Phenomena in Biological Processes' (MIETEN) targeting Horizon Europe.

assistant: **Abstract**

Almost all biological processes, involving molecular trafficking, signal-transduction, cell-to-cell interactions, hinge on precisely orchestrated electrostatic interactions, arising from electrical charges on biomolecules and membranes. Yet, our understanding of the role of electrostatics in these fundamental processes remains elusive due to the absence of quantitative methods to measure the electrical charges of biomolecules and to map the surface charge distribution of membranes. This challenge is further compounded by the requirement of capturing molecular and membrane dynamics that take place at the nanometre length scales and nano- to sub-millisecond time scales. The overall objective of this project is to bridge this technological gap by introducing Metal-Induced Energy Transfer based Electrometry and Nanometry (MIETEN), a groundbreaking technology that will quantify the electrical charge of biomolecules or membranes while capturing their dynamics with nanometre spatial and microsecond temporal resolutions. We will demonstrate MIETEN for measuring: (i) the charges and sizes of individual membrane proteins, (ii) membrane protein structural changes, conformational dynamics, and spatial organization in response to changes in membrane potential, (iii) reaction-diffusion kinetics at a charged membrane, (iv) mechanical properties and dynamics of membranes containing charged inclusions and (v) interactions between two charged membranes. The ability to measure biomolecular and membrane electrical charges and to elucidate the role of electrostatics in structure, organization, and interactions of proteins, as well as in membrane dynamics and intermembrane interactions, will be crucial for our understanding of fundamental biology and for advancing biomedical research. MIETEN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Nanopatterned scaffolds for active myocardial implants'.

assistant: **Concept**

Cell therapy and tissue engineering are emerging as novel therapeutic paradigms for myocardial repair. The rationale behind the cell replacement approach is based on the assumption that an increase in the number of functional cardiomyocytes within the diseased area may improve the mechanical properties of this compromised region. A common strategy attempts to initially combine, ex-vivo, cells with polymeric scaffolds to generate a construct, followed by in-vivo engraftment onto the heart muscle. Despite first encouraging results, the clinical utility of these approaches is hampered by the paucity of cell sources for human cardiomyocytes and by the limited direct functional integration of grafted cells and high degree of donor cell death following cell grafting in host myocardial tissue. NanoCARD will create a conceptually new type of biomimetic nanoscopically designed scaffold able to generate cardiac tissue replacement for the myocardium. Within our project we will design novel cellular environments with broad but precisely-controlled diversity in chemical composition, physical properties, and geometrical spacing of individual peptides on the nanometre scale. The capability of these environments to regulate cell response will be explored by high throughput approaches using a new chip technology developed within the project. An additional unique concept for controlling the function of cardiac cells is given by applying periodic mechanical strain in the range of heart frequency during the tissue engineering process. The knowledge gained within NanoCARD will be translated into the design and production of a novel biocompatible nanostructured device (therapeutic surface) with a desired bioactivity inducing specific behaviour of endothelial cells and cardiomyocytes to revol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Light and complexity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The project is aimed at funding a multi-disciplinary laboratory on nonlinear optics and photonics in soft-colloidal materials and on “complex lightwave systems”. A team of talented young researchers, divided among experiments, theory, parallel computation and nano-fabrication is involved. The proposed research will foster several breakthrough discoveries from soft-matter to biophysics, from nonlinear and integrated optics to the science of complexity and cryptography. The underlying vision is driven by the physics of complex systems, those displaying a large number of thermodynamically equivalent states and emergent properties. There are 4 original and high-impact activities, which explore applicative potentialities: 1) sub-wavelength light filaments in soft- and bio-matter; 2) lasers in soft-matter and bio-tissues; 3) control of soft-matter lasers by light filaments; 4) complex lightwave systems, encryption by nano-structured disordered lasers. Activity 1 will lead to ultra-thin re-addressable light beams (sub-wavelength spatial solitons) propagating in soft- and bio-matter that can be used in laser-surgery, matter manipulation and able to guide high power laser pulses; activity 2 attains novel structural diagnostic techniques in bone tissue surpassing limits of nuclear magnetic resonance imaging, and assesses the field of lasers in soft-materials; activity 3 will demonstrate the control of self-organization processes in soft-matter by light filaments probed by laser emission; activity 4 is based on specific features mutuated from spin-glass theory, and will realize a novel cryptographic technique superior to chaotic systems in terms of security. Activity 1 and 2 are propaedeutic to the others. The team is composed by the Principal Investigator (P.I.), 4 post-doctoral
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FEDErated -system of systems- approach for flexible and interoperable energy COMmunities', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Building on results of recently (or soon to be) concluded EU projects, FEDECOM aims to enable integrated local energy systems through sector coupling and cross-energy vector integration, increasing RES penetration via optimal utilisation of energy dispatch, storage and conversion assets. FEDECOM pursues the idea of electricity becoming the leading energy carrier, with power grids as the backbone for the decarbonisation of all energy sectors and aggregators as the cornerstone enabler of the potential exploitation. FEDECOM adopts and maximizes the potential synergies of two complementary deployment strategies: (i) direct electrification (e.g. via demand electrification), and (ii) indirect electrification (with power-to-X technology). FEDECOM will deliver a scalable and adaptable cloud-based platform composed of analytical, modelling and optimization services for planning, supervision and control of integrated local energy systems (power, gas, heating and cooling, industry, electric and hydrogen mobility). Optimized operations of the integrated systems will be demonstrated as part of hybrid RES/storage infrastructures, while enabling a holistic cooperative demand response (DR) strategy across federation of energy communities. With a concept of federated energy communities, FEDECOM unlocks the flexibility potential, enable energy exchange, and provide coordinated actions across near and remote sites, while maximizing the positive impact on grid transmission level. FEDECOM’s integrated package will be verified on three real large-scale pilots, each composed of multiple (federated) demo sites (communities): Spanish Virtual Green H2 Federation, Swiss Residential Hydropower Federation and BENElux cross-country e-Mobility Federation. After FEDECOM, local energy communities and s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Integration of Estonian medical science into the European research area: towards a healthier society' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The Centre of Molecular and Clinical Medicine is a centre of excellence that brings together the most efficient Estonian medical research groups already working in cooperation with European research institutions. Over the past five years they have received more than 10 European grants. The current proposal is aimed at further strengthening the linkage of our centre with the European research Area. This will be achieved through improved capacity building (attraction of young researchers, introducing new knowledge through PhD programmes, Courses etc.), enhanced international attractiveness (networking support in different research areas) and improved relationships with the economic, medical and social environment in Estonia. To fulfil this task, we shall concentrate our scientific and innovative efforts in the field of neurological and mental disorders, associated with the social and economic burden.