RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cultures of Suspicion in Post-Socialist Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Academic inquiry into conspiracy theories is unquestionably on the rise. Since the turn of the millennium, a new generation of scholars has released conspiracy theory from its earlier associations with individual pathologies, and has shifted attention to its wider social and cultural functioning. Notwithstanding these developments, existing research still tends to treat conspiracy theories in historical and cultural isolation, overlooking their reliance on earlier events and narrative templates, and neglecting their  increasingly digital  transnational dynamic. Focusing on conspiratorial stories and images in Central and East European literature, film, television, commemorative rituals and online culture, during the period 2010-2020, CONSPIRATORIALMEMORY aims to overcome these limitations. The project elucidates the historical references, the transnational interactions and the online circulations that give conspiracy theories their rhetorical and emotional momentum in the post-socialist era. Relying on a theoretical framework that enriches the emerging field of conspiracy theory studies with affect studies and cultural memory studies, the project zooms in on conspiracy-based cultural imaginations from Poland, Russia, Ukraine and Belarus regarding three transnational events that have recently been at the center of international political tensions. Subprojects 1, 2 and 3 each focus on the conspiracy cultures around one of these events, employing the qualitative methodology of Cultural Analysis to examine the intersecting discourses of memory and suspicion. Subproject 4 uses quantitative digital media research methods to analyze the medium-specific contributions of online platforms to memory-based conspiratorial imaginations. The Project Synthesis compares the modes and me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Enhancing Efficiency and Effectiveness in Education' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

High-quality education is a key driver of economic growth and social progress. Despite large investments in education over the past few decades, the quality of education in some EU countries has stagnated or even deteriorated. Marginalized populations are particularly vulnerable to the negative consequences arising from inadequate educational policies. Understanding the efficiency and (cost-)effectiveness of investment in quality education is crucial for allocating resources to where they could have the largest economic and social impacts. The EFFEct research project has been established as an impact-driven initiative that aims to provide evidence-based policy recommendations to improve the quality of education. By investigating the effectiveness and efficiency of education systems and specific policies in EU countries by using (quasi-)experimental evidence, EFFEct advances knowledge in several critical areas, including diversity, equity and inclusion; teachers, trainers and digital transition; instruction and (adult-)learning. EFFEct has four interrelated objectives. Objective 1 offers novel insights on diversity, equity and inclusion by investigating targeted programs for disadvantaged students as well as religious and elite schools. Objective 2 investigates how teacher shortages can be mitigated and examines the role of digital environments. Objective 3 evaluates policies related to instruction, admission standards, and upskilling and reskilling of adults. Finally, objective 4 analyzes how the efficiency of EU educational systems has changed since the COVID-19 pandemic and establishes the main policy levers and qualitative insights that may explain efficiency changes. EFFEct brings together a multidisciplinary research team of economists, sociologists, (neuro-)psycho
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Contrast-Enhanced Magnetic Resonance Angiography' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The objective of the proposed project is the theoretical design, development, synthesis, and preclinical testing of improved high molecular weight paramagnetic complexes and nanoparticles resulting in positive perfusion agents. These compounds should remain almost exclusively in the intravascular space, selectively display the blood vessels, and be safely excreted preferably through the kidneys. They should possess a Tl relaxivity one or two orders of magnitude higher than those of low molecular weight gadolinium contrast agents. The main improvements over existing contrast agents are to be done in relaxivity, specificity, intravascular residence time, and biodistribution.The project will cover the synthesis and the characterisation of new magnetic blood pool agents. This research will be twofold: on the one hand the efficiency (relaxivity) of the magnetic centre will be fine tuned by an extensive study of the factors governing the magnetic interactions between the water protons and the electron-rich centre and on the other hand the nature of the macromolecular (or particulate) carrier will be carefully examined in order to achieve the best blood half-life and guarantee the absence of any toxic effect. Among the microscopic parameters to be studied in the context of relaxivity improvement are the water exchange time between the magnetic centre and the bulk (tm) the field dependence of the electronic relaxation time (ts) and the molecular tumbling rates (tr). In particular the relationships between these factors and the molecular structure will be systematically studied and the influence of covalent and non-covalent binding to large size carriers will be evaluated.This project involves two industrial partners. While a dedicated NMR field cycling instrumentation suited fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of a European quality assurance programme of analytical methods used in the detection of and monitoring of treatment of inherited disorders of metabolism' in the context of a Fourth Framework call.

assistant: **Objectives**

Brief description:During the past years, the laboratory diagnosis of Inherited Disorders of Metabolism (IDM) has evolved from virtually a research activity carried out by a few, predominantly University affiliated academic staff, to assume a more general role in the investigation of patients by non-specialist pediatricians and physicians. Consequently it has become important that, where possible, analytical investigations are standardised, analytical quality control schemes are developed and means of assessing interpretative proficiency are established. These prerequisites provide a proper foundation for accreditation or licensing of laboratories involved in these investigations.Due to differences in analytical methodologies, equipment and in the interpretation of both qualitative and quantitative analytical results, there is poor reproducibility between the results of metabolite analyses in IDM laboratories of different countries. The critical evaluation of laboratory based diagnostic procedures for inborn disorders of metabolism is a prerequisite for the optimisation of detection, diagnosis and treatment of patients suffering from these disorders. There is a need for a clearer understanding of the relative performance of differing diagnostic procedures that could be gained by a comparison of data from different IDM centres within the European Union. A study of the inter-laboratory reproducibility of metabolite analyses in IDM laboratories in the E.U. has been commenced in June, 1994 (Contract N°: BMH1-CT94-1074) by means of a quality assurance program (QAP) set up on a European-wide scale. From the results obtained in the first years of activity (1), it appears that this development was welcomed: 75% of the IDM laboratories listed in the European Directory of Diagnost
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'The relationship between cristae shape and mitochondrial protein import in mitochondrial disease models'.

assistant: **Concept**

The majority of mitochondrial proteins are imported from the cytosol into the organelle. The main mitochondrial protein import pathways account for the import of mitochondrial matrix and mitochondrial inner membrane (IM) proteins, e.g. the subunits of the respiratory chain complexes (RCC). This import process is facilitated by mitochondrial IM and outer membrane (OM) contact sites. Furthermore, the aforementioned pathways depend on the IM elechtrochemical gradient and ATP to take place. The host lab showed that mild overexpression of the dynamin-related protein optic atrophy 1 (OPA1) protects against IM proton electrochemical gradient lost upon complex III inhibition. OPA1 is involved in RCC stabilisation and cristae remodeling, but also in mitochondrial IM and outer membrane contacts. Recently, lower levels of mitochondrial import receptor and channels proteins were linked to Parkinson disease. The hypothesis of this proposal is that OPA1 directly influences TIM23 and TIM22 protein import pathways. This fellowship will follow three main aims; a) define the relationship between OPA1 and protein import in models of Leigh syndrome, b) determine cristae integrity in TOM20, TIM23 and TIM22 deficient cells and c) define protein import machinery molecular partners of OPA1. I will use classical biochemistry and BN-PAGE gels to determine the integrity of TIM23 and TIM22 and to assess the mitochondrial import capacity in the mouse models. Next, I will measure by electron microscopy the shape of the cristae and perform detailed morphometric analyses to determine if the protein import plays a role in cristae biogenesis. Finally, using complexomic analysis, I will aim to identify potential import pathway partners of Opa1 and establish their role by their deletion by CrispR/Cas9 in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Action for research and information support for gas security and supply management in the European grid' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The investigation will consider the future need for research to make feasible the implementation of the Decision Support Systems capable of coping with the mission at the gas operators level and, if considered necessary, at the European co-ordination level. The aim of the investigation is to find a common position among the major groups of actors involved in producing - storing - transporting, delivering and shipping natural gas in the context of the European gas market about the possible architectures of the Decision Support Systems.Finally, this will deliver the database of the flows inside main trunks of the Gas transportation GRID used to draw the conclusions and recommendations. This accompanying measure will contribute to the preparation of future activities of RTD&D and to initiatives of public or policy interest, such as: 98/30 Directive particularly for what regards the monitoring of security of supply issues, pre-normative activities and harmonisation regulations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Planned Departure: B2B Feasibility Study'.

assistant: **Innovation**

Planned Departure is an online business that addresses after-death and estate planning in the digital world, to offer a solution to this problem. It answers questions of transferring online assets by providing the tools to manage a digital life and making it easier to create a succession plan online. Planned Departure is a Software as a Service (SaaS) solution which is safe, reliable and cost effective, to allow storage of important information and after-death instructions, including defining specific beneficiaries to receive the information. Planned Departure seeks funding to conduct a feasibility study to prove technical and commercial viability, conducting an analytical exercise to position the product. The objective is to test the economic viability of the concept and platform among potential clients. By using research, experience and business principles, this feasibility study will determine the probability of the project to sustain itself and offer insight into future expansion prospects. The expected outcomes of the feasibility study are: to validate the business concept by demonstrating the need for a product like Planned Departure for the general public; engage with law firms to demonstrate reducing operating costs and increase profits by offering Planned Departure to their clients; engage with charities to gain interesting insight about their donors in order to raise more money by offering Planned Departure as a service; and prepare for European growth and international expansion.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The Global Marketplace for Optimized Field Work Delivery' in the context of a Horizon 2020 call.

assistant: **Objectives**

SERVIOPTIMAL (Field Service Work Optimization Manager) configures a new work order market, putting in contact the providers of technical services and the clients (persons or machines), demanding technical services. It is a new business tool, providing support to companies in the area of field service management (FSM), as Home Health Services, Operation & Maintenance, etc. On the provider side, it improves its operational efficiency and gives them a huge market to serve. On the client side, it gives them the better price and service quality. SERVIOPTIMAL is a Software as a Service (SaaS) tool, powerful, secure, scalable, easy to configure and integrate in multiple environments, that implements state of the art algorithms for the optimization of resources, artificial intelligence, and the newest software technologies to achieve the better performance and user experience in desktop and mobile apps. In 2013/14, Gartner analyzed the technologies for FSM and positioned them as strategic in its ""Magic Quadrant "", assigning them a high capacity for growth. Furthermore, it was estimated that there is a penetration of FSM tools of only a 25%, and Europe can gain more market share. Moreover, the growth of “internet of things” (more than 50 billion devices in 2025) will act as a “killer application” to demand the service.SERVIOPTIMAL is led by Electrónica Saltó, S.L. (ESALTO), a SME working in FSM field during the last 20 years, a turnover of >10 million €, and a staff of 170 people. At the present, it’s available a fully functional prototype (TRL=7), that is being tested by ESALTO and some potential clients. ESALTO has been investing during a lot of years and now has to enter in the commercial feasibility stage. The feasibility study will cover five areas: Technical, Economic, L
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'IAPP for @utomatic Radio Access Network PLANning and optimisation (IAPP@RANPLAN)' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of this project is to establish lasting relationships between Ranplan, and two academic partners to research and develop automatic planniong and optimisation (P&O) tools for emerging broadband radio access networks such as HSPA (High Speed Packet Access) and WiMAX and the hybrids of such networks with UMTS and Wi-Fi, i.e., Heteregeneous Radio Access Network (HRANs).  The research topics are very important for EU's ICT infrastructure.   The project is highly interdisciplinary as it covers wireless communications, Operations Research (OR), and High End Computing (HEC).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Robustness and specialization among hormone transporters: Redundant and unique roles' (RobustHormoneTrans) under Horizon 2020.

assistant: **Objectives**

Plant growth and development is governed by finely tuned, highly regulated hormone gradients. Impressive progress has been made in understanding plant hormone signaling, but knowledge on the mechanisms underlying their precise localization at the tissue and subcellular levels is still very limited. We and others have recently identified the first bona fide GA transporters in plants as members of the NPF protein family. Proteins from the ABC family were shown to transport the CK, ABA, and auxin hormones. Although these studies suggested specialized functions for members of these large protein families, progress in understanding their level of specialization has been limited by the scarcity of loss-of-function phenotypes, masked by the highly redundant plant genome. The goal of this proposal is to reveal the robust and specialized function of the NPF and ABC plant hormone transporter families. The project places key technological challenges that require multi-disciplinary expertise to examine how plants balance redundancy and specialization to tightly regulate hormone localization. Broad and targeted transportome screens using multi-targeted artificial miRNAs and CRISPR technology in Arabidopsis and tomato, respectively, are designed to unveil novel plant hormone transporters, with an emphasis on subcellular localized transporters and the missing GA exporters. Specialization and robustness of candidate transporters will be evaluated by integrating in vitro transport assays with in vivo growth and development experiments. I believe that the proposed ""redundant-free"" populations will lead to new paradigms in plant genetics and would explain how gene families have developed robustness together with unique and diverse specialization. Importantly, our combined genetic and or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Targeting Cancer with ERV Vaccines' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

InProTher (IPT) is developing a unique immunotherapy  BreakImmune  that effectively targets endogenous retroviruses (HERVs) to treat cancer. HERVs are not expressed in normal tissues, but are expressed in several major cancers, such as breast (88%), prostate (90%), ovarian (90%), and pancreatic (80%). Thus, HERVs can be a potential target for the immune system to destroy tumor cells. IPT technology relies on the engineering of HERVK antigens to be used as effective cancer vaccines. The administration of BreakImmune, the mutated HERVK in Ad19/MVA viral vectors,  induces both strong antibody and T-cell immune responses able to destroy cancer cells in multiple cancer types. Our first product is IPT001, a first in class vaccine against solid cancers in combination with checkpoint inhibitors.


**Keywords:** Immunotherapy,breast cancer,prostate cancer,pancreatic cancer,Therapeutic vaccines,Endogenous retrovirus