RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'PRODUCTION OF FATTY ACID ESTERS USABLE AS FUELS BY FERMENTATION OF BIOMASS'.

assistant: **Objectives**

The objective of the bioconversion project are to develop, at a similar scale tocurrently produced Rapeseed Methyl Ester (RME) project, the production of fattyacid esters by fermentation of biomass.It will :- use glucose substrates or entire crops harvested like straw (triticale) or like silage (maize) or agricultural and agro-industrial wastes;- use a new hydrolysis process (Convertech process invented in New Zealand) or simpler pre-treatments to extract the sugars from biomass;- produce fatty acids by fermentation of sugars (first phase of methanogenesis producing Volatile Fatty Acids) using specific cultures of bacterias and yeasts which specificity in the production of long chain fatty acids or triglycerides;- esterify the fatty acids by methanol or ethanol.Three types of products will be made :- short chain fatty acid esters (octane enhancers);- long chain fatty acid esters (cetane enhancers);- medium chain fatty acids having a market in detergent industry.The work is only fermentation and esterification and comprises 5 parts :1. Optimisation of the fermentations that lead to fatty acids : - trials at laboratory and in small industrial fermenters; - methods for extraction/esterification of fatty acids;2. Genetic modification of one type of oleaginous yeast in order to obtain pure lauric acid or oleic acid;3. Building of an integrated pilot unit;4. Laboratory and bench tests of the esters;5. Synthesis and economic evaluation of the processes.The project will be market oriented, the fuel tests allowing to optimise thefermentation to obtain the best final products (reformulated fuels). 10 partnersfrom 6 countries are associated : 2 petrol companies, 3 universities, 2 publicresearch organisations and 2 small companies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable COATings based on LIGNIn resins and bio-additives with improved fire, corrosion and biological resistance' (LIGNICOAT).

assistant: **Concept**

Sustainability in coatings covers aspects related to energy and resource conservation, waste minimization or efficiency and the use of renewable and non-toxic products. The coatings industry has been driven by regulatory issues to diminish the content of volatile organic compounds to improve indoor and outdoor air quality, shifting from solvent borne systems (still the preferred choice globally) to waterborne ones. However, even in the case of products labelled as “environmentally friendly” their bio-based content is usually small (up to 30-40%). The challenge is to substitute fossil-based resins maintaining at least the same performance. New bio-based value chains are necessary. Lignin is an underutilized product with a high potential to provide not only economic returns, but also environmental benefits if value-added applications are found. Although lignin is a topic of great interest, the conversion of lignocellulosic biomass into real products is not trivial and still no commercial options are available. LIGNICOAT proposal provides new synthetic routes to obtain bioresins “à la carte” (PUD, ALKYD and EPOXY) based on lignin intermediates (Polyols, Epoxies, phosphorylated, polyacids and carbonates) for application in coatings and validated in an industrial relevant environment (TRL5). The target is not only to increase the biobased content and ensure performance, but also take advantage of lignin specific characteristics, to develop bioadditives (enzymes, chitosan, sugars, …), increasing the biocontent and providing anticorrosive, fireproof and antimicrobial/antiviral features in high-volume market case studies. Depending on the intermediates and the resins used, the estimated biocontent of the coatings will vary between 60-90%. A multidisciplinary and complementary c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Planning small medium enterprise networks' (PLENT) targeting Fourth Framework.

assistant: **Abstract**

The PLENT project is performed by a consortium of seven independent partners and four associated partners of three EU countries: Italy, Spain and Greece. An Hungarian partner has jointed the consortium to expend and generalise the experience. The co-ordinating partner is Democenter, an Italian no-profit organisation constituted by several manufacturing SMEs and representing the most important regional enterprise associations and local administrations.The project will develop a set of innovative software tools to support co-ordinated planning in networks of autonomous small-medium manufacturing enterprises. In this context, the most important problem is not the study of a sophisticated decision-making technique but the definition of a planning policy that is based on well defined, completely visible and strictly applicable rules. This is necessary to remove historical distrusts between enterprises traditionally in competition with each other, so as to reach the needed degree of confidence in the network organisation.The project is subdivided into three main phases: network planning; software design, development and testing; system validation and tuning. The first experiment, carried out with the Italian network, aims at verifying the basic planning functionalities in an already constituted organisation. The second experiment, carried out with the Spanish network, aims at verifying the system's capability of coping with frequent interactions caused by duration variability of complex product phases. The third experiment, carried out with the Greek network, aims at verifying the global system performance with respect to a highly reconfigurable network.The project results will be exploitable in three ways: via the user partners, mainly interested in extending the respective
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Vibrational Polariton Nonlinear Optics and Chemistry' under Horizon 2020.

assistant: **Concept**

The strong coupling of a quantum state to a cavity light field has just recently revealed many fascinating effects: Chemical reactions have been dramatically slowed down and nonlinear effects have been enhanced by orders of magnitude. These findings motivate to significantly extend the research on this novel type of light-hybridized matter. The objective of this proposal is to investigate dynamics and structural properties of molecules under vibrational strong coupling for the first time by virtue of mid-infrared femtosecond light pulses. The proposed studies will lead to a significant advancement of the research field with respect to the fundamental understanding of strong coupling induced modifications of matter and applications of vibrational strong coupling in photonics as well as chemistry. The objectives of the proposal are firstly to study the individual contributions of the nonlinear refractive index of carbon disulfide under vibrational strong coupling in a Fabry-Perot cavity. Z-scan and pump-probe experiments with ultrashort near-IR pulses will be conducted. A strong enhancement of the liquid’s nonlinear response is expected and shall be revealed for the first time. It will be employed in low-energy supercontinuum generation triggered by mid-infrared femtosecond pulses.Secondly, chemical reactions of strongly coupled molecules will be investigated by pump-probe spectroscopy in the mid-infrared. Strong coupling induced changes of molecular structure will be revealed by this method and applied to site-selective chemistry enabled by light-matter-hybridization. As a prerequisite, the third objective of the proposal is the development of a widely tunable pump (3000 nm – 10000 nm), broadband mid-IR probe setup. It will be realized by means of a sequential two-stage
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploiting ex vivo expansion and deep multiomics profiling to bring novel, efficient and safer hematopoietic stem cell gene therapies to clinical application' to be submitted under Horizon Europe.

assistant: **Abstract**

Hematopoietic stem cells (HSC) are an elusive cell type, whose presence can only be inferred retrospectively, from the outcome of time-consuming transplantation experiments. Since current state-of-the-art does not allow prospective HSC identification, today’s cell and gene therapy technology has been mostly optimized on surrogate progenitor cells, which differ biologically from HSC. The technological breakthrough of this proposal is to capture HSC in the ex vivo culture, achieved by a combination of innovative expansion conditions, iterative cell sorting and multiomics single cell profiling. Rapid, quantitative and qualitative in vitro HSC assessment predictive of in vivo function may become a sustainable alternative to mouse xenotransplantation experiments. Applied to a state-of-the-art toolbox of genetic engineering technologies including clinically-proven lentiviral vectors as well as established and emerging targeted genome editing approaches, our in vitro HSC readout sets new standards in terms of throughput and turnaround time, allowing to efficiently test a multitude of HSC engineering conditions and tailor the most suitable technological approach to a specific disease or therapeutic application. This new precision-based approach to ex vivo HSC gene therapy will be applied to inherited bone marrow failure syndromes and cancer as paradigmatic examples where gene therapy may be used to correct a cell-intrinsic genetic defect or turn hematopoietic progeny into therapeutic vehicles provided with novel functions. Bringing together experts in cutting-edge gene editing technologies, ex vivo HSC manipulation, assessment of HSC responses to genetic engineering and bioinformatics analysis & integration of multi-dimensional single cell data will maximize the chances of deli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unraveling long-term soil organic matter dynamics under drought in forest soils and their link to ecosystem properties' in the context of a Horizon 2020 call.

assistant: **Objectives**

Severe drought periods are predicted to increase in Central Europe. The increasing frequency of drought will affect the growth and carbon (C) storage in forests. While drought effects have intensively been studied for plants, much less is known about their impact on soil processes. Soils store more C than atmosphere and vegetation together, and contribute to CO2 removal and thus to mitigate climate change.The proposed project aims to estimate how reoccurring summer drought affects long-term dynamics of soil organic matter (SOM) in forest soils. Our research will be carried out in a unique 15-year-long irrigation experiment in a dry oak and pine forest. The project will advance the knowledge and improve its transfer between disciplines by (1) tracing C inputs and fluxes from roots and mycorrhiza into soils and losses of ‘old’ SOM by applying novel isotopic approaches, and relating these changes to soil microbiota analyzed by DNA, (2) determining drought impacts on SOM stability and its sources by innovative marker molecules approaches in SOM pools, and (3) linking these results ecosystem properties measured by collaborating research groups. The use of a long-term experimental set up, together with novel techniques, will offer a unique opportunity to identify the unknown drought-induced effects on belowground C cycling at long time scales. These results will be important for facing current climate change impacts, and will be communicated not only to scientists but also to policy makers and to a wider public.The project will enhance the researcher’s skills in cutting-edge methodologies and techniques, boost teaching and writing skills and increase communication competences, through an ad-hoc spectrum of training activities. As such, future career opportunities will highly
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Innovative manufacturing process for added-value car tyre re-use into safer surfaces'.

assistant: **Innovation**

Every year 22,000 European citizens are killed as a result of slips, trips and falls outside the home and in the vast majority of cases impact on a hard surface causes the injuries that lead to death. The surfaces in question are invariably laid by SME building contractors, of which there are in excess of 200,000 throughout Europe. At the same time, there is an increasing problem of disposal of used car and other vehicle tyres, and by the end on 2006 it will be illegal to landfill even shredded tyres.The material in used tyres has for some time been used to produce impact-absorbing surfaces in sports and playground applications, but its use requires chemicals to be mixed on site. These chemicals are potentially dangerous, and so special handling procedures have to be employed, and the mixing ratios are difficult to control in such situations, leading to variability of the final surface and lack of control over the cost of the surface.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Manipulation and measurement at the nanometre and single molecule levels' under Fifth Framework.

assistant: **Concept**

Applications are invited from doctoral students involved in the synthesis and study of molecular and nanostructured systems to undertake a training period in state-of-the-art nanosclence at the University of Nottingham. The Nanoscience group(www.nottingham.ac.uk/-ppzstm) is part of the School of Physics and Astronomy, providing a dynamic multidisciplinary research environment with rising postgraduate student numbers. Furthermore, both the Nanoscience group and the School as a whole have a strong history of successful training of postgraduate students from the EU and overseas. The doctoral fellow would receive training in a range of areas currently at the cutting edge of nanoscientific research including:- scanning probe microscopy (SPM) and SPM-based manipulation of individual molecules (the Nanoscience group were the first in the world to demonstrate controlled single molecule manipulation at room temperature). The group has a wide variety of in-house constructed and commercial scanning probe instrumentation available including facilities for atomic force microscopy, scanning capacitance microscopy, electric force and magnetic force microscopy, and photon emission scanning tunneling microscopy.- electrical transport and low level optical measurements of nanostructures and adsorbed molecules;- fullerene, carbon nanotube and novel organic systems;- lithography and device fabrication;- synchrotron radiation-based spectroscopies. The group is currently involved in a broad variety of multidisciplinary collaborations, at both national and international level, involving Schools of Chemistry, Biomedical Sciences and Phamaceutical Sciences. We are keen to expand this multidisciplinary activity and thus would particularly welcome applications from doctoral students whose backgro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'From Stick to Screen: Digital Editions of Runic Inscriptions as Research Tools' (FSTS) targeting Horizon Europe.

assistant: **Abstract**

The project “From Stick to Screen: Digital Editions of Runic Inscriptions as Research Tools” will create a born-digital, interactive and open-access critical corpus edition of the runic inscriptions from the four medieval Norwegian trading towns Bergen, Trondheim, Oslo and Tønsberg. It will address the challenges of proper digital representation of runes from a multidisciplinary perspective, aiming to present a solution to existing challenges.The main objective of the project is to examine new ways of digitally editing and analysing runic inscriptions with a view to how digital museums/editions can be actively used to conduct research. Two case studies will be undertaken to show how the new digital edition of the runic inscriptions from Bergen, Trondheim, Oslo and Tønsberg can immediately be used as a tool for research. The case studies represent two further research objectives of the project. The first case study focuses on the diachronic and geographical spread of runes and variations of runes within these four towns, and will try to identify regional differences in the use of certain runic characters in the material. The second case study will analyse the diachronic and geographical spread of the names appearing in the runic inscriptions from these four towns with a view to the identity, geographic mobility and gender distribution of the rune-carvers.The project will rely on the infrastructure at the Museum of Cultural History, University of Oslo, to publish and link high-quality photographic documentation of the runic inscriptions to data collected about these inscriptions. Photographs and research data combined will form the new digital edition. This in turn will be made accessible to all interested audiences at the end of the project as an interactive tool. The re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Identification of Genes Controlling Senescence in Human Epithelial Cells: Role in Cancer' (EPITHELIALSENESCENCE) under Seventh Framework.

assistant: **Objectives**

Cellular senescence was originally described as the cell cycle arrest that accompanies the exhaustion of replicative potential in cultured primary mammalian cells. Whereas ‘replicative’ senescence is triggered by telomere erosion, other stimuli such as activated oncogenes, oxidative stress, DNA damage and sub-optimal culture conditions can also induce a senescent phenotype called ‘premature’ senescence or ‘stasis’. Senescence acts as a potent antitumor mechanism. Malignant transformation occurs after the bypass of senescence caused by mutations in oncogenes and tumour suppressors. Thus, novel genes linked with oncogenesis can be isolated by identifying genes regulating senescence. As the majority of solid tumours arise from cells of epithelial origin, the aim of the current project is to identify genes controlling senescence in epithelial cells. Specifically, human prostate epithelial cells (HprECs) will be studied as the corresponding prostate cancer represents the most frequent cancer amongst men. A genetic screening for senescence bypass will be performed in these cells using a retroviral shRNA library. The validated genes will be prioritized thanks to a parallel microarray based-analysis of transcriptional changes associated with senescence in HPrECs and to existing databases that evaluate expression profiles in human tumours. The expression of the relevant candidates will be then confirmed in a wider and independent subset of clinical tumour samples using tissue micro-array. Finally, the oncogenic properties of the candidate genes will be analysed in several models of tumourigenesis. Overall, the investigation described here aims at using senescence as a system to identify novel tumour suppressor genes.