RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Pages of Prayer: The Ecosystem of Vernacular Prayer Books in the Late Medieval Low Countries, c. 1380-1550' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Vernacular prayer books were by far the most commonly read book in the late medieval Low Countries. The mainstay of this vast corpus is the Book of Hours in the translation by Geert Grote (c. 850 manuscripts and 30 printed editions), founder one of the period’s most powerful religious reform movements. Nowhere else outside the Netherlands do so many manuscript and printed editions of this type of prayer book survive in the vernacular. While these books are fundamental for our understanding of religiosity, and of textual and visual literacy between 1380 and 1550 - a period that saw dramatic changes in the religious landscape and in book production - the sheer volume of material and its diversity has prevented researchers from fully grasping the nature and impact of this vibrant phenomenon.Pages of Prayer sets out to conduct the first large-scale investigation of this unique corpus by introducing a new approach - network philology - that studies all aspects of vernacular prayer books in their mutual interdependence. The project aims to chart the entire ecosystem of Dutch-language prayer books - including manuscripts, printed books, texts, images, producers, owners, patrons, places, devotions, and the relations between all of these aspects - over a long period of time by combining quantitative network analysis with advanced qualitative analysis to reach meaningful interpretations of the data.The nature of the material requires this research to be tackled within a multidisciplinary project. All members contribute to the digital network analysis. Sections of the ecosystem are further analyzed in work-packages that focus on the production and reception of manuscripts, the poetics of prayer, the function of images, and changes and continuities in relation to religious movement
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Frontiers in Mechanism Design: Methodology and Applications' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Mechanism design is the engineering side of economics. Research findings in this field have helped governments and practitioners worldwide design better institutions: auctions that are more profitable or efficient; labour markets that improve the match between employees and employers; and better ways to assign students to public schools.  The cornerstone of mechanism design is the revelation principle, which provides a canonical class of mechanisms and turns the mechanism-selection problem (which a priori may appear unmanageable) to a constrained optimization problem. The standard mechanism design paradigm relies on three fundamental assumptions: 1. The designer of the institution—the principal—does not have any privileged information. 2. The principal chooses the mechanism and commits to it once and for all. 3. There is no interrelationship of the mechanism with outside markets. In addition, almost the entire mechanism design literature assumes that private information is unverifiable (soft). These assumptions often fail in today’s “big data” world: Firms (online retailers, insurance companies, banks) do have privileged—and often certifiable—information that may affect contractual terms they propose. Also, they interact repeatedly with the same agents and, as they learn about them, they attempt to change the terms by making personalized offers. Finally, often a mechanism—e.g. a government insurance program—interacts with private insurance markets. The proposed research aims at providing methods and foundations to design optimal mechanisms at precisely those highly relevant situations: 1. mechanism-design by an informed principal, 2. design of mechanisms and their transparency when the principal lacks commitment, 3. mechanism-design when an intervention interacts with m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Regulatory rules and evolution of neuronal gene expression'.

assistant: **Innovation**

Complex brain functions require a remarkable degree of cellular specialization. Understanding the mechanisms guiding neuronal specification programs remains a major challenge. Here we use the nematode C. elegans, an essential animal model for studying the general principles of neuron specification, to provide answers to four fundamental questions: 1) How are regulatory landscapes coordinately activated in each type of neuron? We previously showed that complex combinations of transcription factors (TFs) implement neuron-type specific programs. TF behaviour at the genome-wide level is not well-understood. Our expertise on dopaminergic and serotonergic neuron specification will be instrumental in answering this question.2) How are TF interactions mirrored by syntax rules of the regulatory genome? Our preliminary data demonstrate extensive TF-TF cooperativity that is mirrored by specific syntax in the target enhancers. We will use massively parallel reporter assays and bioinformatics to begin decoding the rules of the neuronal regulatory genome.3) Does regulation of basic translational machinery play a role in neuronal differentiation? The mechanisms regulating the basal translational machinery are emerging as a new dimension in the regulation of cell type specification. We recently found the conserved translation initiation factor eIF3A is required for serotonergic terminal differentiation, opening the door to the study of this novel regulatory role for eIF3 complex.4) How do new types of neurons emerge during evolution? We will combine our unique expertise on neuron specification with the amenability of the Caenorhabditis species and novel single-cell technologies to unravel the regulatory mechanisms underlying the appearance of new neuronal types in evolution.Our work wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Evidence Based Planning of Future Clinical Research' (EBAR), addressing dissemination and exploitation.

assistant: **Impact**

Clinical studies that are planned without prior consideration of existing evidence potentially experiment with an unnecessarily large number of patients or try to answer a question to which the answer is already available. This project aims to develop a framework of efficient and sustainable research planning that minimizes cost and has the potential to direct resource allocation by optimally planning future clinical studies based on existing evidence. A circular updating process is suggested; before a trial is planned the existing evidence (a network meta-analysis) about the effectiveness of all competing interventions is considered and its conclusiveness is statistically evaluated. If further experiments are needed these are designed considering patient’s preferences and with an aim to render the existing evidence conclusive. The new data is then used to update the existing knowledge. This innovative approach to plan clinical studied requires methodological developments from various fields (biostatistics, operational research, epidemiology) and its feasibility will be evaluated in answering a real clinical question about the best intervention for a given condition and in designing a new trial. The circular updating process is of high interest to public research funding bodies, guideline developers and pharmaceutical companies. The project has a strong public engagement component as patients and major health care organizations are involved in many of the planned activities in the development of the circular updating process. The project will be carried out in a stimulating academic environment (University of Bern) with extensive experience in clinical trials and a secondment in Novartis is planned. I will acquire technical skills in clinical trials, will continue to pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-wavelength studies of solar fine structures.' under Sixth Framework.

assistant: **Concept**

High-resolution coverage of the Sun both from space and ground-based telescopes is leading to a plethora of observations of small-scale dynamic structures observed from the chromosphere to the transition region and corona. Nowadays, there is a general consensus that the key to understanding how the solar plasma is accelerated and heated may well be found in the studies of these fine structures. Among them spicules seem to be the most prominent ones characterizing the chromospheric network. While these chromosperic structures are observed and studied for several decades in the visible, near UV and recently also in EUV emission lines and continua, there are still many questions to be answered. The dynamics of spicules and other fine structures may well have broad implications for the mass and energy balance of the outer atmosphere of the Sun and the solar wind.In this work we will perform:a) the study of short term dynamics of spicules,b) the determination of their physical parameters (morphology, temperat ure density, velocity etc) and their temporal evolution,c) the contribution of fine structures to the mass and energy budget of the solar chromosphere and corona.The work will be based on:a) the data analysis of existing observations, as well as new coordinated multi-wavelength observations of spicules and other small-scale structures and their longitudinal photospheric magnetic field with SOHO, TRACE and ground-based telescopes (THEMIS and DOT),b) interpretation of the results andc) theoretical work to describe the physical processes in a rather quantitative manner.This theoretical work will include non-LTE radiative transfer calculations of the Halpha line profile and evaluation of the proposed heating mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Useful energy from contaminated landfill gas' under Horizon 2020.

assistant: **Concept**

Cleanergy will plan and demonstrate (in phase 1 and 2) a solution for exploration and production of a technical solution thatutilizes low-grade methane landfill-gas with a more efficient production of heat and electricity and better control of emissionsfrom the combustion than existing technology. The combustion in the stirling engine application will be optimized. The projectfocuses on variations in the fuel which affect combustion and components. The challenge of Phase 1 refers to the varyinggas composition and impurities. Research data shows that the gas composition and its compounds vary not only over timebut also by season and weather. The project allows landfill-gas extraction to last long, be more predictable and stable andtake care of pollution that would otherwise not be treated. In Phase 1 , we intend to identify various landfills wheredemonstrations can be made with different conditions and geography that reflects the market potential but also technicalchallenges. This way, we involve users in Phase 1 in order to better plan Phase 2. We will also examine if we need extrapartners in Phase 2. A market survey will be conducted to know the proportion of landfills in Europe that have a gascollecting system and the landfills that flare. The flaring landfills represent the primary target in a first exploitation phase. Arisk analysis will secure the measurements and method to be used in the demonstration phase in order to give valid results.In Phase 1 an innovation strategy will be developed and the European dimension will be refined. We will investigate potentialobstacles for the company's ability to be profitable in the exploitation phase in order to secure the return on investment.Overall, the pilot will evaluate the feasibility of the concept and the idea for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'UNMANNED VEHICLES FOR CIVIL SECURITY AND SURVEILLANCE MISSIONS' (PROACTIF) under Horizon Europe.

assistant: **Objectives**

PROACTIF develops unmanned vehicles based framework for civil security, combining cutting edge UxVs, sensors, components, mission control and multi-domain teaming for safe and secure surveillance of critical infrastructures and for efficient management of emergency situations. The project concept is based on R&D in three technology domains (TDs): TD1 is dedicated to UXV perception capabilities, enabling an unmanned vehicle to observe the surrounding world, including e.g. radars, LiDARs and antennas, as well as IR, hyperspectral and electromagnetic sensing, and edge-could managing of related data. TD2 will focus in UXV mission management, enabling command and control, connectivity, location and positioning, cybersecurity and teaming needed for the complex operations by unmanned vehicles, also paving the way to autonomic vehicles. TD3 will focus in developing of 5 UxV platform capabilities; UAV, USV and 3 different UGVs.  All the technology building blocks developed in TD1 and TD2 will be demonstrated both individually and on TD3 platforms in relevant civil security missions. The mission cases represent the different security needs of the civil society, including offshore, seaports, rail yards, energy substations, emergency sites, wildfires, search and rescue and crowd monitoring and teamed UxV operation. The results provide focused contributions to the SRIA 2024 topics.  PROACTIF aims to ensure that Europe is well prepared for the whole range of different security challenges and emergency situations, with the aid of technologies that will be available in different geopolitical situations - technologies whose ownership and manufacturing capabilities are in Europe.   The consortium includes 42 partners from 13 different countries: 18 SMEs, 11 LEs and 13 RTOs, covering the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Adsorption and Dynamics of Nucleic Acids on Surfaces in Ionic Liquid Environment'.

assistant: **Objectives**

Nucleic acid storage and stability is of primary importance as it finds uses in material science as nanomachines, biosensors and bioelectronics. The long-term stability and storage of DNA is a major challenge as hydrolytic reactions cause its denaturation when stored in an aqueous environment with conventional buffer solutions. Most of the devices employing nucleic acids require the nucleic acid molecule (generally DNA) to be adsorbed on the surface with a solvent in its immediate vicinity. The search for suitable solvents and electrolytes received a boost with the advent of ionic liquids (ILs). Nucleic acids have showcased enhanced chemical and structural stability in ILs compared to conventional buffer solutions. However, to employ ILs as electrolytes or solvents in biosensors and bioelectronics it is paramount to understand the effect of IL ions on the adsorption and dynamics of DNA molecules on surfaces. The objective can be achieved by employing a synergistic approach of microscopy, spectroscopy and theory. Time lapse scanning force microscopy (SFM) and Tip Enhanced Raman Spectroscopy (TERS) supported by computational studies will give a comprehensive idea in this regard. In essence, the central research objective of NAIL is to understand, the role of the various stabilizing interactions on Nucleic Acids imposed by the ions of Ionic Liquids on the adsorption and dynamics of the former on surfaces. Along with the research objectives, the ultimate goal of the project is to propel me, Sugosh Prabhu to a position of professional independence at the forefront of academic/industrial research by enhancing my innovative potential, diversify my individual competences; and also to open up new avenues in terms of collaboration for me and the host organization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of  new multi-valent vaccine systems against Candida pathogens'.

assistant: **Innovation**

The fungal pathogen Candida albicans is the most pathogenic of the Candida species and causes millions of superficial mucosal infections and approximately 200,000 deaths per annum due to invasive and disseminated disease in susceptible patient populations. Fungal infections in immunocompromised patients have an unacceptably high mortality rate of approximately 40%, and the yearly healthcare expenditure for the treatment of fungal diseases is estimated to be $15 billion. The clinical treatment of fungal diseases is hampered by poor and time-consuming diagnostics, a limited repertoire of anti-fungal drugs, and increasing levels of resistance to anti-fungal prophylaxis. Crucially, there are currently no licensed vaccines against fungal pathogen. Recent attempts to formulate vaccines have involved delivering simple mixtures of peptide/protein components of the target fungi with adjuvants (without controlled chemical conjugation), and without specific synthetic control have met with limited success. This project will develop new vaccine candidates to Candida albicans, the leading cause of fungal infection in humans worldwide. Unlike previous efforts, a multi-valent approach will be employed, chemically coupling three proteins expressed by Candida albicans. This synthetic approach will ensure the concurrent delivery of multiple protein antigens to overcome barriers faced by previous attempts at developing vaccines. Specifically, the project will focus on the synthesis of multi-valent systems by conjugating proteins to the surface of either: i) dendrimeric scaffolds (3D nanoscale covalent structures) or ii) liposomes (3D nanoscale self-assembled structures). This multidisciplinary proposal will use cutting-edge methodologies to address an unmet clinical need in fungal immunolo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Validated non-invasive liquid biopsy tests for cancer PREDIction in LYNCH Syndrome' (PREDI-LYNCH), addressing dissemination and exploitation.

assistant: **Impact**

We propose an ambitious yet well-conceived and deliverable pan-European, pan-cancer, pan-disciplinary, and multi-omic approach to address the pressing unmet need for an accurate, non-invasive, acceptable and cost-effective method of detecting precancerous and early-stage cancers in those individuals with Lynch syndrome (LS), the most common monogenetic increased hereditary cancer risk. LS has historically been underfunded and underserved, leading to significant an inequality in access and treatment. As a result, LS carriers have suffered needless cancers and deaths as a result.   Our consortium has brought together the leading European experts, biotechnology companies and patient advocates to guarantee deliver practice-changing results that can be rapidly upscaled and adopted across the European Union and globally. Using an innovative clinical trial design, we will evaluate several multiple promising, non-invasive, liquid biopsy-based technologies in the three most common LS cancer types for an early-stage cancers detection. By leveraging Artificial intelligence (AI), we will identify traces of cancer, ensuring applicability to diverse healthcare systems. A comprehensive framework will assess the broader socio-economic and ethical impacts, ensuring that the solutions align with the societal values and healthcare needs. Parterning with leading biomarker companies (GNT, MSInsight, MSICare, MSIPlus and Elypta), we aim to deliver a multi-omic solution for affordable, accessible and effective test to advance the detection of heritable cancer detections in LS. This action is part of the Cancer Mission cluster of projects on “Prevention & early detection (early detection heritable cancers).


**Keywords:** Liquid biopsy; microsatellite instability markers; metabolomic markers