RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Microporous carbons for gas storage and delivery'.

assistant: **Innovation**

Research objectives and content The purpose of this project is to improve the development of microporous carbons for gas storage. Microporous carbon monoliths can provide a high adsorption capacity at room temperature and low pressure (3-4 MPa). The present project will involve four steps. The first step consists in optimizing the porous structure of three new types of carbon monoliths (from wood waste materials, carbon fibres and paper-derived carbons) in order to maximize the volumetric capacity of gas adsorption. Usual methods will be used to characterize the produced carbon materials in terms of their adsorption capacity. High pressure methane adsorptive capacity will be then determined for the most promising materials. The third step is devoted to the building of an apparatus in the aim of measuring deliverable capacity of the carbons under heat transfer conditions. The final step is to develop monolith forms which will be suitable for incorporation into vehicle fuel storage assemblies. Training content (objective, benefit and expected impact) The aim of the present project, carried out in the Carbon Materials Research Group (Bath University), is to optimize microporous carbon monolith properties. The combination of Bath University knowledge and investigation techniques plus my own scientific experience should lead to develop novel monolithic carbons, suitable for adsorbed natural gas. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'New generation of solar thermal systems' under Sixth Framework.

assistant: **Concept**

The objective of this project is to introduce more cost-effective solar thermal systems, particularly for domestic hot water preparation and / or space heating, to the market in order to contribute to the European Union's Action Plans with regard to the reduction of CO2 - Emissions and the cost-effective supply of renewable energies. In order to achieve this goal the project provides a framework for the development of the next generation of solar thermal systems and their Introduction to the market.The main instruments and deliverables of this project will be- A network for the co-ordination of the research and innovation activities for the development of a new generation of solar thermal systems- Accompanying measures for the introduction of a new generation of solar thermal systems for domestic hot water preparation and / or space heating to the markets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pan european thematic network on cultural landscapes and their ecosystems', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The plurality of anthropogenic influenced European ecosystems compose Cultural Landscapes. These main contributors to European biodiversity, quality of life, heritage and identity, are threatened by socio-economic changes and landscape related policy. PAN gathers active research groups of Europe to assemble existing knowledge and develop overall understanding of man as a landscaping factor and to assess vulnerability and functioning of Cultural Landscape and their Ecosystems for dissemination to the scientific, political and public audience. PAN objectives are to develop common strategies, basic scientific tools to protect European biodiversity and to encourage sustainable use; Achieved by cross correlating research efforts and pointing to gaps in current knowledge; Resulting in recommendations for large-scale sustainable development of Cultural Landscapes and criteria to assess the role and function of landscape-management for the protection/conservation of European landscapes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cooperation Of Space NCPs as a Means to Optimise Services for Horizon Europe (plus)' to be submitted under Horizon Europe.

assistant: **Abstract**

COSMOS4HEplus proposal is the successor of COSMOS4HE and previous projects of Space NCP network. The consortium consists of NCP organisations from 15 countries balancing geographical coverage as well as diversity in level of expertise. The overall aim of COSMOS4HEplus is to support the professionalisation of the services rendered by the National Contact Points in Cluster 4 thematic area of Space in Horizon Europe and provide additional services targeting Space clients and applicants at EU level and beyond. The activities are structured according to the propoCOSMOS4HEplus proposal is the successor of COSMOS4HE and previous projects of Space NCP network. The consortium consists of NCP organisations from 15 countries balancing geographical coverage as well as diversity in level of expertise. The overall aim of COSMOS4HEplus is to support the professionalisation of the services rendered by the National Contact Points in Cluster 4 thematic area of Space in Horizon Europe and provide additional services targeting Space clients and applicants at EU level and beyond. The activities are structured according to the proposal’s specific objectives: 1) to increase the quality and support harmonisation of Space NCPs services, 2) to lower the entry barriers for newcomer applicants, to attract new types of players and applicants from widening countries, as well as to raise the quality of submitted proposals, 3) to increase the visibility of the thematic area of Space to new types of players by organizing matchmaking activities and ensuring bilateral communication about the crosscutting issues throughout Horizon Europe for the benefit of the European R&I community. The consortium will closely cooperate with the two other Cluster 4 NCP networks in thematic areas Digital and Industry deve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-pronged Strategies to Regain Voluntary Motor Functions after Spinal Cord Injury' under Seventh Framework.

assistant: **Concept**

Severe spinal cord injury (SCI) permanently abolishes motor functions caudal to the lesion. Various strategies have beenpursued to promote functional recovery after such injuries. However, none of these attempts were able to return voluntarymovements in paralyzed subjects. Here, we propose an innovative transdisciplinary research program including parallelapproaches that will converge into an integrated multi-pronged therapy able to restore voluntary movements after paralyzingSCI. To achieve this goal, we will capitalize on our recent breakthroughs that demonstrate the impressive capacity ofpharmacological and electrical spinal cord stimulations to promote full weight bearing walking in paralyzed rats whencombined with rehabilitation. In Walk Again, we will improve high level control of spinal circuits with synergistic combinationsof pharmacological agents, and with the design of multisite stimulation strategies using electrode arrays. Functional electricalstimulation of muscles will provide complementary low level tuning capacities to adjust limb motion. To allow voluntary control,we will establish a new line of research and pioneer brain-spinal interfaces by which cortical modulations will directly adjuststimulations of spinal circuits and muscles. In the final stages, we will enable neurorehabilitation with this cortico-spinalneuroprosthesis in the presence of anti-NogoA regenerative therapy. The underlying objective is to devise a fully-operativeneuroprosthetic system that will enable self-driven rehabilitation in a permissive plastic environment. Walk Again will fertilizefrontier research with pioneer ideas that will increase European competitiveness while paving the way toward viable clinicalapplications to restore function in paralyzed individuals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Nanonets2Sense' under Horizon 2020.

assistant: **Concept**

Nanonets2Sense proposes a new technological approach, where random networks of nanowires, called nanonets (NN), allow biosensors for medical applications to be integrated at low cost with a 3D integration scheme. The final objective of the project is to demonstrate 3D above-IC integration of nanonet-based sensing devices on a CMOS platform. By using nanonets as sensing material, our synergetic approach retains the advantages of nanowires (NW) properties without the associated technological burden. With a smart combination of bottom-up and top-down technologies and a low processing temperature (<400°C) compatible with CMOS integration, it allows 3D integration into a compact sensor, where the sensing element, which is exposed to breath or biofluids, is integrated above the CMOS detection circuit, which is naturally protected.Nanonets2Sense will address all material, device and circuit issues. It will develop the integration process that allows the 3D above-IC integration of NN-based sensing devices on a CMOS platform, optimize sensor performance by engineering nanonet properties and device dimensions, analyse NN-based devices operation and performance and optimize readout accordingly, demonstrate the viability of the integration approach by fabricating a proof-of-concept integrated sensor that realizes 3D SoC integration of a NN-based sensing device with its CMOS read-out.Nanonets2Sense is thus providing a new technological building block to enhance CMOS chip functionality with biosensing capability. It combines high performance at low cost and the impact is enhanced by the fact that the approach is generic and can be adapted to a large variety of NW and target molecules. Nanonets2Sense relies on well recognized European partners, including academic, SME and large compan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of antagonists of vascular leakage' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Dysregulation of capillary permeability is a severe problem in critically ill patients, but the mechanisms involved are poorly understood. Further, there are no targeted therapies to stabilize leaky vessels in various common, potentially fatal diseases, such as systemic inflammation and sepsis, which affect millions of people annually. Although a multitude of signals that stimulate opening of endothelial cell-cell junctions leading to permeability have been characterized using cellular and in vivo models, approaches to reverse the harmful process of capillary leakage in disease conditions are yet to be identified. I propose to explore a novel autocrine endothelial permeability regulatory system as a potentially universal mechanism that antagonizes vascular stabilizing ques and sustains vascular leakage in inflammation. My group has identified inflammation-induced mechanisms that switch vascular stabilizing factors into molecules that destabilize vascular barriers, and identified tools to prevent the barrier disruption. Building on these discoveries, my group will use mouse genetics, structural biology and innovative, systematic antibody development coupled with gene editing and gene silencing technology, in order to elucidate mechanisms of vascular barrier breakdown and repair in systemic inflammation. The expected outcomes include insights into endothelial cell signaling and permeability regulation, and preclinical proof-of-concept antibodies to control endothelial activation and vascular leakage in systemic inflammation and sepsis models. Ultimately, the new knowledge and preclinical tools developed in this project may facilitate future development of targeted approaches against vascular leakage.


**Keywords:** Endothelial permeability, growth factor, vascular leakag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Innovative inland ship design and production' (1994-1998).

assistant: **Concept**

Inland shipping plays an important role in European transport by providing cost efficient and environment-friendly links for about 50 % of all transport volume between sea ports and hinterland. Additional opportunities arise with the opening of the Main-Danube link and the intensifying of trade between West and East Europe. To take advantage of these developments it is required that inland shipping further increases its standards on cost efficiency, safety and low environmental impact. To achieve these higher standards innovative designs of inland ships and efficient operations by shipyards to build and maintain these are required. Selected areas of ship design innovation address resistance, propulsion and manoeuvring in limited waterways, safety, low environmental impact, the use of advanced weight-efficient materials and a modular approach to production-efficient ship structures. Selected areas of production innovation address building strategies which are based on low environmental impact, facilitating enterprises for parts manufacturing and block assembly and high levels of mechanisation and automation. Enterprises involved in the building, exploitation and maintaining to standard of inland ships are usually SME-shipyards and shipping companies. These have limited or no capabilities to innovate and to use technology as a means to improve their ability to provide effective and cost-efficient products and services to inland shipping and need assistance from RTD performers in above mentioned fields of expertise. Reducing ship hull cost price by 30 % and building time by a third are examples of projected improvements.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Regulation of g2 cell cycle arrest mediated by p38 map-kinases' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

P38 marpks are activated by stresse and they are involved in the cell growth arrest. P53 protein has a key role in this process and it is regulated by phosphorylation by p38mapks at several sites. P53 phosphorylation by p38 mapks will be analysed as well as the related cell cycle modification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Strengthen and develop scientific and technological excellence in research and therapy of leukemia (CML, AML, ALL, CLL, MDS, CMPD) by integration of the leading national leukemia networks and their interdisciplinary partner groups in Europe' to be submitted under Sixth Framework.

assistant: **Abstract**

Leukemias are a challenge to society and a cost factor because of their frequency in all age groups. They also serve as a model for a variety of diseases and possess exemplary relevance for basic research and patient care. Leukemia research and therapy have achieved high standards and even a leading position in several European countries with regard to clinical trials, standardization of diagnostics and molecular studies of signal transduction and gene expression. A true European world leadership, however, has not been accomplished yet due to national fragmentation of leukemia trial groups, diagnostic approaches and treatment research activities and a need for central information and communication structures.The objective is to integrate the leading leukemia trial groups (CML, AML, ALL, CLL, MDS, CMPD), their interdisciplinary partners (diagnostics, treatment research, registry, guidelines), industry and SMEs across Europe to form a cooperative network for advancements in leukemia-related research and health care.Integration will be supported by central information, communication, education and management structures. Other goals are to intensify target and drug discovery, to shorten the time period to clinical translation, to apply advanced genomics, telematics and biotechnology to therapeutic progress and to promote research relevant also for solid cancers by large clinical trials. Furthermore, metaanalyses of specific subaspects, elaboration of prognostic scores, recognition of gender specific differences, creation of uniform data sets for trials and registration, introduction of standards for diagnostics and treatment and development of evidence-based guidelines will be promoted throughout Europe. The proposed network will have the expertise and critical mass for Eur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'New technologies for imaging and quantification of tumour angiogenesis with ultrasound contrast agents' to be submitted under Sixth Framework.

assistant: **Abstract**

Cancer is one of the worst killers in the world and a big burden on society. In Europe alone, there are 2.9 million estimated new cases and 1.7 million deaths each year. Tumour angiogenesis - the formation of new blood vessels and the remodelling of the existing vasculature in a solid tumour - has become the object of intense efforts of biologists and other scientists to understand, identify, and treat cancer. Imaging of cancer angiogenesis is important for early diagnosis, prognosis, and monitoring of new therapies that target tumour vasculature. Current non-invasive methods for imaging tumour angiogenesis (PET, CT, MR) have been proven inadequate. Over the past decade, microbubble contrast agents for ultrasound have matured from an investigational tool to a clinical tool capable of imaging flow at the level of microcirculation, both non-invasively and in real-time.At the present, there are few, if any, methods available for the quantitative characterization of tumour vasculature morphology and flow. It is this problem on which we focus in the present work. The objectives of this work are to create high resolution tools for direct micro-vessel imaging and flow measurement in tumours, by developing 2D and 3D imaging and quantification methods with contrast enhanced diagnostic ultrasound. Applications beyond the liver and kidney, such as the breast, where inherently low flows present a scientific challenge will be addressed with maximum intensity projection techniques.A rigorous teaching program will be established in the area of biomedical imaging at the University of Cyprus. Fundamental and applied research will be performed in both an academic and clinical environment with participants spanning from under- and post-graduate students, to visiting professors, and clinic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SUB nanosecond Leverage In PET/MR ImAging' (SUBLIMA) targeting Seventh Framework.

assistant: **Abstract**

The SUBLIMA project aims at truly simultaneous, fully integrated, solid-state PET/MR technology for concurrent functional and anatomical imaging with unsurpassed image quality. It will combine the extremely sensitive functional imaging possibilities provided by PET with the excellent soft-tissue contrast and complementary functional imaging capabilities of MR. For the first time, time-of-flight (ToF) and depth-of-interaction (DoI) correction will be introduced together into a PET/MR system. SUBLIMA will also be the first to exploit the unique advantages of truly simultaneous PET/MR acquisition by enabling fully 4D MR-derived motion correction. Furthermore, artefacts seen in PET-CT will be eliminated by developing MR-based, motion-compensated PET attenuation correction. The SUBLIMA platform will thus realize a breakthrough in image quality and enable novel applications in oncology, cardio-vascular medicine, and neuro-degenerative diseases. SUBLIMA will not only introduce new methods and technologies in each important component of the imaging chain, but it will also analyse the system performance as a function of all relevant design parameters, in order to push the image quality to the physical limits by optimally merging these innovations into 7T preclinical and 3T whole-body human demonstrator systems. This integrated approach also warrants adaptation of the project results for optimum performance in stand-alone PET and SPECT applications. The consortium, lead by Philips, consists of universities, research institutes, industrial partners, and SMEs, spread over 7 different countries including the USA. While each partner has shown exceptional quality in its own field, the consortium brings together the wide and complementary range of expertise necessary to push the perfor