RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting spinal cord ependymal cell heterogeneity by single-cell transcriptomics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cells with stem cell potential, this is with the ability to self-renew and generate specialised progeny, exist in the adult mammalian spinal cord. Previous studies localised this potential within the ependymal cell (EC) population. However, ECs are rather heterogeneous based on their morphological features and the expression of a handful of neural stem cell markers. In this interdisciplinary research proposal, I aim to uncover the cellular and molecular heterogeneity of ECs at the level of individual cells. I propose to take advantage of cutting-edge single-cell RNA-sequencing technology to obtain the transcriptomes of individual ECs from the spinal cord of adult mice. Using advanced computational methods, I will establish EC types and states and use pseudotemporal ordering to elucidate potential lineage relationships among ECs. I will then validate these findings in the tissue context, using high-resolution confocal microscopy. This first comprehensive characterisation of spinal cord ECs will provide novel and fundamental insights into how ECs possess and maintain their unique self-renewing properties. In the future, this will facilitate realisation of the potential of spinal cord stem cells for therapeutic purposes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Innate signaling networks in B cell antibody production: new targets for vaccine development'.

assistant: **Concept**

The long-term goal of this proposal is to explore a novel immune pathway that involves an unexpected interplay between marginal zone (MZ) B cells and neutrophils. MZ B cells are strategically positioned at the interface between the immune system and the circulation and rapidly produce protective antibodies to blood-borne pathogens through a T cell-independent pathway that remains poorly understood. We recently found that the human spleen contains a novel subset of B cell helper neutrophils (NBH cells) with a phenotype and gene expression profile distinct from those of conventional circulating neutrophils (NC cells). In this proposal, we hypothesize that NC cells undergo splenic reprogramming into NBH cells through an IL-10-dependent pathway involving perifollicular sinusoidal endothelial cells. We contend that these unique endothelial cells release NC cell-attracting chemokines and IL-10 upon sensing blood-borne bacteria through Toll-like receptors. We also argue that IL-10 from sinusoidal endothelial cells stimulates NC cells to differentiate into NBH cells equipped with powerful MZ B cell-stimulating activity. The following three aims will be pursued. Aim 1 is to determine the mechanisms by which splenic sinusoidal endothelial cells induce reprogramming of NC cells into NBH cells upon sensing bacteria through Toll-like receptors. Aim 2 is to elucidate the mechanisms by which NBH cells induce IgM production, IgG and IgA class switching, and plasma cell differentiation in MZ B cells. Aim 3 is to evaluate the mechanisms by which NBH cells induce V(D)J gene somatic hypermutation and high-affinity antibody production in MZ B cells. These studies will uncover previously unknown facets of the immunological function of neutrophils by taking advantage of unique cells and tissu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Malleability in mediated ideals: A paradigm to understand effects of contemporary media in adolescents’ well-being' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

MIMIc will develop and establish a new theoretical perspective that will fundamentally redirect the current research on idealised representations of life in mass and social media and their effects on (adolescent) audiences. MIMIc combines insights from cultural sociology, media theory, and developmental psychology to define the effects of ‘malleable ideals’ in media. Malleable ideals are idealised representations of different achievements and are characterised by the malleability that surrounds these achievements; they approach ideals from a utilitarian, individualistic discourse that links personal responsibility and dedication with both the failure and success of achievements. By focusing on malleable ideals and thus applying a sociocultural analysis to media ideals, a crucial perspective will be added to our understanding of the development of adolescents and, more precisely, the pressures they experience. These pressures are viewed as an important factor in the relatively high prevalence of both internalising and externalising problems in adolescence. Content analytical, diary, and longitudinal studies in three different cultural contexts will be triangulated to develop a theoretical model: MIME. Content analyses map the extent to which media abound with aesthetic, sexual, professional, romantic, and social ideals as well as the importance of malleability in these representations. Longitudinal and diary research examine the internalisation of these ideals as a key explanatory process for the effects they may have both on outcomes regarding personal and societal problems and among different groups of adolescents. The multimethod approach further allows the theorisation and testing of the role of varying time intervals associated with understanding the effects of medi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CULTIVO AEROPONICO CON ENERGIAS RENOVABLES' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

Aeroponic is an improvement, with high ecological benefits, of the hydroponic technics.In horticulture it allows productions at a continuous cycle thus resulting in competing advantages which are interresting for the entire European Area : Whteh saving, higher organoleptic propieties, simple methodology and easy to learn and which totally eliminates contamination and erosion of soil. In a small agricultural undertaking, whateverr activity being carried out, the family members, may directly exploit an aeroponic plantation and thus obtain, ini proportion to the cultivated surface, a higher income than by any other produce grown in a greenhouse or in the open.During the last years aeraponic investigations have been carried out obtaining positive result.A demonstrating project, which will develope a continuous cycle of aeroponic growths, will reveal theses results and confirm the technoeconomical effciency of the new system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Coupling chip technology and affinity capillary electrophoresis for a faster, cheaper and high-throughput analysis of biological systems'.

assistant: **Innovation**

Microfluidic 'lab-on-a-chip' technology has revolutionized laboratory experimentation, thereby, demonstrating the potential of miniaturization, integration, and automatization to research-based industries.There is also a great need in the area of drug de sign and development to develop analytical techniques that require small amounts of material and which can analyze samples expeditiously and provide accurate measurement of physicochemical parameters. The proposed research is unique and innovative in that it combines state-of-the-art microfluidic and capillary electrophoresis (CE) separation techniques with molecular derivatization.Although CE on a microchip is relatively well-established the coupling of it to molecular derivatization reactions has only recently been examined and only in the Gomez laboratories. The chip electrophoresis technology needs mainly microfluidic and electromigration research.The applicant has a basic knowledge on both fields, however, he is not familiar in CE on a chip, and he cannot acquire this expertise in Hungary. At this time the best place to obtain this knowledge is in California (United States) in the labs of Professor Frank A. Gomez, where both chip electrophoresis technology and affinity CE can be studied.The applicant hopes to transfer the cutting-edge chip-CE technology from the United States to a less-favoured, eastern region of EU. The research will develop analytical techniques including design, preparation, and application of microfluidic devices and CE and will focus on examining molecules and enzymes involved in disease and public health.To create 'lab-on-a-chip' devices, manufacturing methods from the microchip industry were coupled to techniques involving fluid dynamics, analytical chemistry, and biochemistry resulting in m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced epitaxy of metamorphic semiconductor structures for multijunction solar cells' under Seventh Framework.

assistant: **Concept**

The objective of METACELLS project is to develop the epitaxy technique for the growth of metamorphic semiconductor structures that allow to realize the full efficiency potential of concentrator multijunction solar cells, paying special attention to the subsequent manufacturability and cost-effectiveness of the solar cells developed.Eventually, this growth technique will allow to fabricate a monolithic multijunction (3 - 4 junctions) solar cell exhibiting ~75% of the maximum theoretical efficiency calculated for the standard direct terrestrial spectrum (i.e. approaching 50%) at 1000 suns, using only one growth step and minimizing costly post-processing.The implementation of the optimum subcells bandgap combination, using materials with the required photovoltaic quality will be pursued. The metamorphic MOVPE growth technique will be revisited by in-depth understanding of strain and relaxation dynamics during growth of lattice-mismatched layers, using in-situ monitoring, which will be the central research topic. Development and functional multijunction cell structures, including the tunnel junctions, optimized for operation at 1000 suns, is aimed.The epitaxy routines for the growth of the step-graded buffer layers will be cost-optimized so that the process time and gases consumption are reduced while keeping the material quality unaffected. A decrease around 10% is projected to be attained, resulting in a similar reduction in fabrication cost.The accomplishment of METACELLS project objectives will contribute to widen current European excellence in high efficiency concentrator cells development and industrialization, allowing the many companies involved in this business to lead the market with the best performing product. This will enable Europe’s involvement in further res
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Next generation clinical decision-support & education'.

assistant: **Objectives**

Current medical teaching practice is still largely based on textbooks and lectures. Students struggle to get access to relevantclinical experience and teaching consistency. As a result, they are often underprepared for the challenges of real worldclinical situations which requires them to assess interrelated symptoms and signs whilst simultaneously refining a list ofdifferentials and moving to a diagnosis.DemDX combines powerful clinical reasoning software powered by machine-learning with a reporting dashboard allowinginstitutions to draw teaching insights from how students interact with the course material. DemDX support students innavigating correlated symptoms in order to reach at the correct diagnosis with greater certainty and in a shorter time.DemDX is also a powerful tool for continuous professional education and for clinical triage where nurses must evaluate theurgency of an appointment from a phone request.Our content is contributed by a global community of specialists (200 medical contributors from top institutions such as Guy'sand St Thomas' NHS Foundation Trust, Imperial College London, Beth Israel Harvard Medical School) providing real-timeupdates. Our clinical reasoning software already includes 1,300 diagnostic paths over 13 medical specialties enabled by100,000 algorithms.DemDX is currently accessible a free mobile application (iOS or Android) with basic functionalities and has beendownloaded by 30,000 users since late 2016. We intend move to a freemium model once the full product is ready, where anannual fee of €70 will grant access to all content and functionalities.DemDX has already gathered interest from leading medical schools such as King's College London (UK), Federal Universityof Minas Gerais (Brazil) and the Ministry of Health is considering rol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A generic framework for analyzing temporal structure in music' (RhythMus).

assistant: **Concept**

The sensation of rhythm in music is evoked by accents that follow a more or less regular structure in time. This structure takes the shape of a rhythm hierarchy consisting of note onsets, the pulse of a piece, rhythmic patterns, and, finally, the units of the musical form. Many computational analysis methods concentrate on one level of the rhythm hierarchy in isolation, and ignore the importance of melody for rhythm. This project proposes a Bayesian framework for the analysis of rhythm, which takes into account the relations between the hierarchy levels, and the impact of melody on rhythm.Most current approaches are further limited in their universality, because they are tailored towards certain paradigms of Western music, such as the well-formedness of meter. By analyzing music which contradicts common paradigms, we aim at a set of analysis tools that gives us access to a wider variety of music. The developed methods will be evaluated on Western and on non-Western music, which will ensure the universality of the proposed methods.This project will contribute directly to the state-of-the-art in Music Information Retrieval (MIR), an area with growing economic impact. The proposed methods will permit implementing novel computer-based learning and music recommendation platforms for types of music that currently cannot be analyzed by the state-of-the-art. Geographical location and chosen musical context maximize the direct economic impact of such learning and retrieval platforms. The project will profit from a wide variety of expertise. The fellow is a specialist in rhythm analysis, and the host institution has high expertise in Bayesian rhythm modeling and machine learning, consultants of the project are experts in musicology and melodic analysis of non-Western music.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of sustainable solutions for nanotechnology-based products based on hazard characterization and LCA' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Objective of the NanoSustain project is to develop innovative solutions for the sustainable design, use, recycling and final treatment of nanotechnology-based products This will be achieved by a comprehensive data gathering and generation of relevant missing data, as well as their evaluation and validation, for specific nanoproducts or product groups in relation to their human health and environmental hazards and possible impacts that may occur during after-production stages. Although production of nanomaterials is rapidly increasing, our knowledge about possible health and environmental effects associated with these materials is still rather poor. This lack of knowledge calls for more research. Due to their small size, nanoparticles behave different than their chemical analogues. They can be taken up easily and in a unique way with possible adverse effects in man and organisms. Assessing their hazard is complex and needs new approaches and a close international cooperation. NanoSustain will address the questions, (1) how and to what degree society and the environment will be exposed to nanomaterials and associated products, and (2) where do these particles end up? Expected results will improve our present knowledge on the impact and fate of these particles after entering economic and natural cycles. NanoSustain has mobilized the critical mass of expertise, resources and skills to tackle this complex issue. Based on results from hazard characterization, impact assessment and LCA, we will explore on a lab-scale new solutions for the design of selected nanomaterials and associated products and their sustainable use, recycling and final treatment. As the concerned nanotech industry will actively participate in the planned project, NanoSustain will set the ground for the de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting Multidrug Resistant Cancer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Despite considerable advances in drug discovery, resistance to anticancer chemotherapy confounds the effective treatment of patients. Cancer cells can acquire broad cross-resistance to mechanistically and structurally unrelated drugs. P-glycoprotein (Pgp) actively extrudes many types of drugs from cancer cells, thereby conferring resistance to those agents. The central tenet of my work is that Pgp, a universally accepted biomarker of drug resistance, should in addition be considered as a molecular target of multidrug-resistant (MDR) cancer cells. Successful targeting of MDR cells would reduce the tumor burden and would also enable the elimination of ABC transporter-overexpressing cancer stem cells that are responsible for the replenishment of tumors. The proposed project is based on the following observations:- First, by using a pharmacogenomic approach, I have revealed the hidden vulnerability of MDRcells (Szakács et al. 2004, Cancer Cell 6, 129-37);- Second, I have identified a series of MDR-selective compounds with increased toxicity toPgp-expressing cells(Turk et al.,Cancer Res, 2009. 69(21));- Third, I have shown that MDR-selective compounds can be used to prevent theemergence of MDR (Ludwig, Szakács et al. 2006, Cancer Res 66, 4808-15);- Fourth, we have generated initial pharmacophore models for cytotoxicity and MDR-selectivity (Hall et al. 2009, J Med Chem 52, 3191-3204).I propose a comprehensive series of studies that will address thefollowing critical questions:- First, what is the scope of MDR-selective compounds?- Second, what is their mechanism of action?- Third, what is the optimal therapeutic modality?Extensive biological, pharmacological and bioinformatic analyses will be utilized to address four major specific aims. These aims address basic questions con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Green and digital continuous-flow pharmaceutical manufacturing'.

assistant: **Concept**

Greening and digitalizing pharmaceutical manufacturing is one of the grand challenges of Europe's pharma-industry. It offers a significant opportunity to boost productivity, improve competitiveness and reduce the industry large environmental footprint. Current progress is impaired by shortage of trained engineers and scientists, who can design green and digital pharmaceutical processes.This MSCA doctoral network will focus on addressing these skills gaps, delivering a cohort of highly-skilled and trained PhD graduates that will lead the green and digital transformation of the pharmaceutical manufacturing, both in academic and industrial environments. The consortium brings together 7 universities, 1 research center, and additional 11 associated members from academia and industry. This will address urgent topics in continuous green manufacturing and develop greener routes to prepare pharmaceutical products, promoting the adoption of novel technologies (flow synthesis instead batch methods, heterogeneous nano and biocatalysis in lieu of homogeneous catalysts, renewable carbon sources, novel purification methods, digitalization tools) for sustainable manufacturing.Specific PhD topics for 10 ESRs have been outlined. The research and training programme will equip the ESRs with key scientific and transferable skills, such as IPR, entrepreneurship, data and innovation management. The consortium strong track record in the management of interdisciplinary research and training will ensure effective and timely training of the next-generation leaders of Europe’s pharma-industries. The exposure to academic and industry sectors will also provide the researchers with unparalleled career opportunities.


**Keywords:** Flow Chemistry, Synthetic Chemistry, Pharmaceutical Synthesis, Green