RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The development of advanced numerical tools to study and control supersonic particle beams in Cold Spray' (SSAM).

assistant: **Concept**

“Supersonic Spray Advanced Modelling - SSAM” is an ambitious project, which proposes the development of new computational tools to model the acceleration of micro-sized metallic particles in a novel manufacturing process known as Cold Spray (CS). In this method, powders are entrained in a supersonic jet stream (carrier gas) and are accelerated up to high velocity levels (>1000m/s). This enables the generation of high energy impacts against a substrate material, and allow for the formation of a coating or deposit in a melt-free manner.However, the current understanding of CS working principles and mechanisms is up to now incomplete. This programme proposes the development of full multi-phase computational tools tailored for this process, and suitable for supersonic regimes. New mathematical models will be developed, and implemented in a numerical package to resolve in the deepest detail carrier gas-particles interactions at dynamic and thermodynamic levels. Theoretical results will be validated using state of the art experimental apparatuses, currently available within the Researcher host premises.The development of this programme will set the basis for further research projects, and is part of a larger long-term plan aimed at engineering the first ever melt-free and mask-free metal deposition process for polymer and non-metallic substrates. A summary of details is included in this application.The Researcher is a leading expert in CS, with major contributions at academic and commercial levels. The award of a FP7-CIG grant is vital. It will enable the Researcher to demonstrate his capabilities over established staff members (through the opening of his first PhD programme as Supervisor) and will provide the opportunity to collaborate with them in an exciting project. Ultim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Synthetic Natural Killer Cells for Immunotherapy' (SYNKIT) targeting Horizon 2020.

assistant: **Abstract**

Cancer remains a leading cause of death worldwide, urging for innovative therapies. Infusion of natural killer (NK) cells, which possess an intrinsic capacity to eliminate cancer cells, is a promising treatment option for various tumours. Genetic engineering of NK cells before transfer allows to specifically tailor and modulate their anti-tumour responses. One particularly attractive strategy for broad implementation of NK cell immunotherapy in an “off-the-shelf” setting is to expand large numbers of NK cells from induced pluripotent stem cells (iPSCs). However, this approach is limited by two main bottlenecks: i) poor persistence of allogeneic iPSC-derived NK (iNK) cells due to rejection by the recipient immune system and ii) impaired functionality due to failure to achieve complete differentiation in vitro.The SYNKIT project seeks to address both of these current limitations through genetic engineering of iNK cells for increased persistence and function. Deletion of human leukocyte antigen (HLA) ""self-ligands"" allows the transferred cells to escape from host T cells. However, absence of HLA also triggers “missing-self” recognition and rejection by host NK cells. In addition, new insights from the host laboratory into the molecular mechanism underlying NK cell education have unravelled a pathway of functional disarming in NK cells that lack self-ligands, further diminishing the anti-tumour efficacy of HLA-deficient NK cells.In SYNKIT, I will use HLA-deficient iNK cells as a platform to assess how introduction of synthetic self-ligands modulates the allogenicity and functionality of iNK cells. The overall goal of SYNKIT is to identify synthetic self-ligands, which reduce recognition by the host immune system and yet prevent functional disarming of the engineered iNK c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Evolution and epidemiology of human malaria / mosquito interactions.' in the context of a Sixth Framework call.

assistant: **Objectives**

Malaria remains one of the most successful diseases of human both in terms of its prevalence and of defying our attempts at control. Contributing to its success is the fact that its transmission fails to be prevented by the immune response of its human host or its mosquito vectors. Indeed, malaria parasites are only rarely killed by their mosquito vector's immune response in natural situations. One possible explanation for the lack of resistance is that the cost of the immune response prohibits the spread of resistance or that the parasites suppress the immune response. To study this phenomenon I have chosen an approach that mixes epidemiology and evolutionary ecology. The project will consist in determining links between the spatial variations in the epidemiological situation and several components of the mosquito's immune system and thus to evaluate possible costs of the constitutive and inducible immune responses and to determine how malaria parasites drive the selection of genes involved in the resistance of their mosquito vectors. Results of this work will help to determine if and under which conditions resistance of mosquitoes against malaria parasites can be selected. As transgenic mosquitoes are currently being designed to resist malaria parasites and are considered as a potential weapon to fight malaria, the proposed project has important implications for future malaria control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Erythrocytes properties and viability in dependence of flow and extra-cellular environment' to be submitted under Horizon 2020.

assistant: **Abstract**

After exiting the bone marrow, reticulocytes mature to form red blood cells (RBCs) which are highly adapted cells Red blood cells (RBCs) travel through our circulation during their entire lifetime of in average 120 days. This means they are in constant move and adapt to their surrounding by shape changes, e.g., when in high speed flow or with even more severe volume adaptations, when they squeeze through small capillaries or the slits of the spleen having less than half their own size. While on the move, RBCs have to deal with continuous changes in oxygen tension and pH, have to scavenge reactive oxygen species, and need to balance their responses towards the chemical and mechanical challenges. In contrast, most of the knowledge we gained about RBCs as well as diagnostic methods rely on RBCs in relative  stasis, such as flux measurements, conventional patch-clamp, calorimetric assays, density centrifugation, atomic force microscopy, just to name a few. In the most extreme conditions the cells of investigation are even dead like in blood smears, electron microscopy or cyto-spins. Even if cells are on the move like in flow cytometers, they may rest in a drop of liquid. Furthermore, when taken from the circulation, the flow of the RBCs is suddenly terminated and (together with the application of anticoagulants) they experience a completely different environment that is likely to impair their properties. The objective of EVIDENCE is the exploration of the properties and behaviour of RBCs under flow conditions and in vivo to understand pathophysiology and to design novel diagnostic devices. Theoretical models will help to understand these RBC properties and will enable the transfer of the gained knowledge into diagnostic devises in general and into the development of a splee
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'PROcessing MEtaphors: Neurochronometry, Acquisition and DEcay'.

assistant: **Concept**

As the master figure of speech, metaphor is a powerful communicative tool that might nevertheless come with costs for our processing system. Research in different fields has highlighted that a full-fledged metaphor comprehension capacity is a late achievement in development, it may decay as a consequence of several pathological conditions, and it evokes distinctive electrical activity in our brain compared to literal equivalents. However, we still miss a comprehensive framework able to account for all these empirical findings in a unitary fashion, and this despite a vast number of linguistic and cognitive accounts of metaphor. This project will ground on theoretical insights from the pragmatics of language to sketch a novel and comprehensive model of metaphor understanding able to account for neural, developmental, and clinical findings. The leading hypothesis is that metaphor comprehension is an inferential process that involves first adjusting the lexical concepts, and then deriving the implicated -non-literal- meaning. The model also takes into account the multiplicity of metaphor types, which might in turn engage visual images and sensory-motor processes, in line with recent multimodal accounts of lexical and semantic processing. The model will be tested and refined through a series of behavioral and electrophysiological studies employing innovative experimental paradigms and involving neurotypical adults, children, and individuals with psychiatric and neurodegenerative diseases. This multidisciplinary approach will lead to a significant breakthrough in our understanding of metaphor as the pinnacle of human verbal creativity, in addition to disclosing important aspects for research on language processing, development and decay.


**Keywords:** metaphor; experimental
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'PHOtoCathalytic Systems for CLean Energy and Environment Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The research purpose of PHOCSCLEEN is to investigate a number of photo-catalytic oxide nanomaterials, classify them and produce new composite materials with tailored properties. Selected materials will be investigated in the light of application aimed to environmental clean-up and water splitting for hydrogen production. By exploiting the complementarities of partners, the following goals will be reached:1. Improvement of the technical knowledge in the area, achieved thanks to a systematic characterization of the properties and processing of photo-catalytic oxide nanomaterials, and by investigating and optimizing the integration schemes of optical energy sources within the photocatalytic reactor,2. Increase of the cooperation among the participating institutions and, more in general, between Europe, Canada and Mexico in this area; besides the support to the joint research among senior researchers (ERs), this will be achieved by training young researchers (ESRs) not only from a scientific point of view, but also enhancing their ability to work within an international team combining expertise coming from different research centers;3. Support to and ease of the transfer of the existing expertise from one partner to another, both in terms of knowledge, and in terms of expertise on tools and processes. Eventually this will lead to the creation of a structured network of institutions cooperating in this area. This will also include the transfer of know-how in project setup and management to allow for the construction of a stronger management base to better define and guide future EU projects on the mentioned research area.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Wearable Sweat-based painless and continuous glucose monitoring device for diabetic people' (Elektrosens).

assistant: **Innovation**

There are 60 million people with diabetes in the EU (10% of total population). Diabetes is the major cause of death in the age of 20- 79. Also, Europe has the highest number of children with Type 1 diabetes (T1D) compared to other regions with approximately 140,000 diagnosed children and it has one of the highest prevalence rates of diabetes in children with 21,600 new cases per year. The frequent glucose monitoring is the key element in achieving good glycemic control which is the most important factor in preventing diabetes related complications such as diabetic retinopathy, kidney damage, heart disease, stroke and etc. Due to the high cost of the current CGM devices or pain associated with traditional finger-prick measurement, people cannot monitor their blood glucose level continuously. In 2015, 627,000 people aged between 20-79 died due to diabetes related complications. UK prospective study shows that continuous glucose monitoring leads to improved glycemic control, which in turn results in reduced diabetes related complications. Study shows that with continuous glucose monitoring diabetes related retinopathy and nephropathy (eye damage) in type 1 and type 2 diabetes decreased around 60% and microvascular complication rate decreased 25%.Elektrosens Wristband uses a highly selective and accurate novel polymer technology sensing very low sweat glucose levels which are correlated to blood glucose. Our innovative solution makes the continuous glucose monitoring affordable for all customer segments. The main objectives of this product can be divided into two groups; mainly providing a sustainable healthy lifestyle and reducing the economic burdens., we now aim to introduce our technology to diabetes devices market seeing how our solution offers significant performance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'INTEGRATED WASTE MANAGEMENT IN WESTERN AFRICA' (IWWA), addressing dissemination and exploitation.

assistant: **Impact**

Most of African countries are struggling towards development and improving their living conditions. An appropriate waste management structure at a national and regional level is a milestone that must be achieved in order to improve living standards, health and environment. The situation in many countries is that the obvious lack of a functional waste management system brings perennial garbage problems such as inefficient garbage collection, poor public compliance to waste segregation, uncontrolled open burning, and tolerated presence of open dumpsites. Furthermore valuable resources are lost due to inefficient or non-existing recycling systems. The establishment of an efficient waste management and recycling system contributes to enhancing the resource efficiency of these countries and thus supports a sustainable development in the long-term. The present Coordination Action will seek the establishment of Integrated Solid Waste Management systems (ISWM) in Western Africa. ISWM systems combine waste streams, waste collection, treatment and disposal methods, with the objective of achieving environmental benefits, economic optimization and societal acceptability. For the achievement of the project objectives, a solid waste management expert and research co-ordination platform will analyze the current situation in the targeted countries (Ghana, Nigeria, Senegal and Ivory Coast), identifying main gaps and constraints of any type (technological, sociological, organisational, etc.) and selecting suitable management systems. According to the results obtained, including inputs from authorities and policy makers in participatory workshops, the consortium will provide valuable guidelines and recommendations to be used in the future implementation of developed strategies such as Nat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Improvement of ceramic substrate of three-way catalysts (twc) to develop a regeneration and/or reactivation procedure of used catalysts' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The objective of the project is to expand the durability of motor vehicle catalysts by (i) improvements in ceramic support properties and (ii) by regeneration of used catalysts through removal of chemical poisons by dissolving or by extraction and/or reactivation of active sites by thermo/chemical treatments in order to recover the metal area lost by sintering. Attention will be paid to the damage imposed by the severe conditions under which catalysts are subjected while in use or that regeneration procedures may cause to ceramic honeycomb. New ceramic materials will be prepared that withstand the regeneration procedures and/or with higher resistance to deterioration. The best regeneration procedures will be environmental and economically evaluated in order to estimate its commercial viability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Structures in Ionized Models of Dusty Protoplanetary Disks' (SimplyDisks).

assistant: **Concept**

Understanding how planets form in disks around young stars is a fundamental part of astrophysical research. With the advent of the Atacama Large (Sub-)Millimeter Array (ALMA) and other large-scale telescopes and interferometers, the field of planet formation has been transformed by the stunningly complex structures observed in disks around young stars in the solar neighborhood. But at the same time, theoretical models have struggled to explain these observations, in part because many physical processes are investigated individually.Therefore, a more comprehensive model of protoplanetary disks is needed. With the SimplyDisks project, I will perform the first global 3D Magneto-Hydrodynamic simulations that treat the interaction of dust, gas and magnetic fields within protoplanetary disks self-consistently. The simulations will focus on the outer regions of the protoplanetary disk, where ambipolar diffusion suppresses the development of the MRI, and where the Vertical Shear Instability is active in the midplane regions. The self-consistent treatment will be achieved through the development of an extended ambipolar diffusion module. With these models, I will be able to (1) analyze magnetic and pure hydrodynamic processes occurring in protoplanetary disks in context and unveil if they are the driving forces behind the observed structures, and (2) find locations of dust concentration that survive long enough to trigger the formation of planets. Together with observations, the results from these self-consistent models will help us understand where and how planets form, and thus why our solar system looks different from many systems observed around other stars.


**Keywords:** protoplanetary disks, magnetic fields
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Highly efficient protein rich biofertilizer, 100% spirulina based, for agricultural yield increase and crop quality traits enhancement' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

A doubling in global food demand projected for 2050 due to rising poses huge challenges for the sustainability of food production systems. To satisfy the growing demand, the only feasible solution is to increase productivity on existing agricultural land. Traditionally, growers have made use of synthetic fertilizers for production increase but these products pose serious risks on ecosystems, living animals and human health. In this context, biofertilizers emerge as an efficient alternative to traditional fertilizers, able to boost crops yields and maximize the quality traits of fruits and vegetables but without the harmful effects.  In this proposal, the Spanish agro-biotechnology Jaro Innovaciones presents agroCYAN ECO, a liquid biofertilizer, phosphate-free, obtained by enzymatic hydrolysis of the spirulina biomass, a cyanobacteria highly rich in L-amino acids of easy absorption, phytohormones and other nutritive substances. When our biofertilizer is applied to plants, crop yields are increased up to 33% and the quality traits of the harvested products are significantly improved since  agroCYAN ECO favours roots’ development, stomata’s opening and nutrients’ acquisition. agroCYAN ECO is the cheapest solution among its competitors and can be applied to any horticultural product and to vines, citrus trees, olive trees, etc. agroCYAN ECO has been especially formulated for its use in organic agriculture, having been certified to this end. Its application can be done as a foliar spray, in fertigation or for the preparation of nutritive solutions, reducing the doses of the other treatment products up to 20%. The main risk for agroCYAN ECO commercialization in the European market is the lack of a harmonized regulation, although the current fertilizer regulation is being revi