RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'FOR THE CIRCULAR ECONOMY OF TYRE DOMAIN: RECYCLING END OF LIFE TYRES INTO SECONDARY RAW MATERIALS FOR TYRES AND OTHER PRODUCT APPLICATIONS'.

assistant: **Concept**

The BlackCycle project has an upcycling ambition, targeting to create a circular economy of the end-of-life tyre (ELT) into technical applications like tyre industry by producing high technical second raw materials (SRMs) from ELTs. A key lever is to consider the circular economy of tyre domain: recycle ELT into new tyres. Known technologies in this domain are today limited and this new research project will have the ambition to pass their roadblocks, and deliver new technical raw materials relevant for tyre production or other technical products. This project will proactively integrate these new materials (SRMs) and validate that the progress in all the key tyre performances having environmental impacts is not slowed down.The BlackCycle project aims at creating, developing and optimising a full value chain, from ELT feedstock to SRMs, with no waste of resources in any part of the chain and a specific attention for the environmental impact. Eventually, close to 1 out of every 2 ELT will go through this new recovery process which will be the only virtuous cycle of this magnitude amongst all industrial sectors in the recovery of end of life products. In effectively implementing this change, the European tyre industry will be a world leader in a more sustainable tyre production.Indeed, the main product obtained at the end of the project would be a new tyre where many raw materials come from ELT. In particular,  the carbon black, a material representing ~20% of tyre composition, will be fully obtained from oils extracted from waste tyres through the pyrolysis process. Furthermore, several chemical and plasticizers will also be obtained from pyrolytic oil refining.The final product would have a high added value from an environmental point of view, because more than 25% of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Developing novel tools and technologies to assess the safety and efficacy of cell-based regenerative medicine therapies, focusing on kidney disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The RenalToolBox ITN comprises a team of world-leading clinicians, scientists and industrialists from academia and private enterprise whose common goal is to develop innovative medical devices and imaging technologies to expedite the translation of cell-based regenerative medicine therapies (RMTs) to the clinic. The target disease for RenalToolBox is kidney disease, the incidence of which is increasing annually. The ITN provides an excellent framework for training 15 early stage researchers (ESRs) in a range of technological, entrepreneurial and transferable skills that will not only enhance their career prospects, but will also boost European scientific excellence and business innovation. By the end of the programme, the ESRs will have benefitted from a comprehensive multidisciplinary and multi-sectoral training experience that will equip them to expedite progress in the emerging supradisciplinary fields of biomedical devices, bio-imaging, cellular therapeutics and regenerative medicine. The research training objectives are as follows: 1. Train the young researchers in the development of diagnostic devices and novel tracers for monitoring renal function. 2. Apply cutting-edge imaging technologies to evaluate the safety and efficacy of novel cell-based RMTs in a rodent model of kidney disease. 3. Assess the safety and efficacy of different sources of mesenchymal stromal cells and explore the mechanisms whereby these cells can ameliorate kidney disease. This comprehensive training programme will endow the young researchers with the necessary scientific and industrial skills to ensure their employability and readiness to engage and lead the next European generation of scientists-entrepreneurs.


**Keywords:** kidney disease,  mesenchymal stem cells,  multimodal imaging,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'VERy high Throughput Satellite-Ground Optical Link'.

assistant: **Objectives**

Next-generation satellite systems will be essential to bridge the digital divide and offer high speed connectivity for all by 2025. Optical feeder links are the most advanced communication solution to the future VHTS system requirements. VERTIGO ambition is to establish the required breakthrough by developing the on-board and ground concepts and technologies enabling for a drastic increase of the link throughput towards and beyond 1 Tbps. VERTIGO is set to meet three major objectives: 1) Throughput increase: while current space optical comms use 1bit/symb modulation formats, VERTIGO will prove advanced schemes with higher spectral and power efficiency, including RF-over-Fiber approach. 2) High optical power generation: to close the demanding link budgets, VERTIGO will develop on-board and ground means to raise the transmitted optical power, not only based on amplifier power increase, but also on incoherent/coherent power combining. 3) Mitigation of atmospheric propagation impairments, to make full use of throughput and power increases. Opto-mechanical techniques using adaptive optics and aperture diversity, and digital processing (error correction coding/interleaving) will be developed to enhance the robustness of future optical feeder links. This unprecedented combination of concepts will result in leading-edge system solutions. Full-scale demonstrations will prove the expected end-to-end performance. VERTIGO ambitions to pave the way towards very high throughput satellite systems and contribute to maintain EU technological leading edge and industry competitiveness. VERTIGO consortium is composed of the different parties of the supply chain, from technology providers to satellite equipment and system vendors, and satellite operator as an advisor. VERTIGO gathers well-e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The first in the new millenium xliv scientific conference of polish chemical society and association of engineers & technicians of chemical industry' (ENVIROCHEM).

assistant: **Innovation**

1. Exposition of environment endangers in the Silesia region.2. Influence of the cross boarder transport on the environment change.3. Exposition of the role of Polish legal regulation adjustment to EU norms in environmental protection on acceleration in environment remediation in Silesia region.4. Exposition of actual achievements and evaluation of the economic effectiveness of the changes.5. Polish chemists in environmental improvement programme - definition of the role
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Re-designing the value and supply chain of water and minerals: a circular economy approach for the recovery of resources from saline impaired effluent (brine) generated by process industries' (2014-2020).

assistant: **Concept**

This project aims to facilitate the implementation of the Circular Economy package and the SPIRE Roadmap in various process industries by developing the necessary concepts, technological solutions and business models to re-design the value and supply chains of minerals (including magnesium) and water, while dealing with present organic compounds in a way that allows their subsequent recovery. This is achieved by demonstrating new configurations to recover these resources from saline impaired effluents (brines) generated by process industry, while eliminating wastewater discharge and minimising environmental impact of industrial operations through brines (ZERO BRINE). The project will bring together and integrate several existing and innovative technologies aiming to recover end-products of high quality and sufficient purity with good market value. It will be carried out by large Process Industries, SMEs with disruptive technologies and a Brine Consortium of technology suppliers across EU, while world-class research centres ensure strong scientific capacity and inter-disciplinary coordination to account for social, economic and environmental considerations, including LCA. A large scale demonstration will be developed in the Energy Port and Petrochemical cluster of Rotterdam Port, involving local large industries. Two demo plants will be able to treat part of the brine effluents generated by one process industry (EVIDES), while the waste heat will be sourced by neighbouring factories. The quality of the recovered end-products will be aimed to meet local market specifications. The involvement of representatives covering the whole supply chain will provide an excellent opportunity to showcase Circular Economy in Rotterdam Port, at large scale. Finally, three large-scale pil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications' in the context of a Horizon 2020 call.

assistant: **Objectives**

Validation of an in vivo translational medicine approach for the treatment of diabetes and diabetes complications To develop new drugs for treatment of diabetes, there is an immediate need for an in vivo approach allowing the assessment of β-cell function and survival in the living organism non-invasively, longitudinally and at single-cell resolution. We therefore transplant pancreatic islets into the anterior chamber of the eye (ACE) of mice for functional microscopic imaging. In the ACE islets become vascularized and innervated, and various aspects of β-cell function and survival can be readily imaged. Functional studies demonstrate that engrafted islets in the eye serve as representative reporters of endogenous islets in the pancreas of the same animal. We have extensively in vitro tested fluorescent biosensors that reflect key-events in β-cell function and survival. Following intraocular transplantation of human islets expressing biosensors in their β-cells into healthy or diabetic mice, they will allow non-invasive, longitudinal in vivo monitoring of 1) Ca2+ handling, 2) functional β-cell mass, 3) apoptosis and 4) proliferation. Based on the in vitro tested biosensors, the major objective is to establish a robust pharma-industry in vivo platform for validating newly developed diabetes treatment lead-compounds in early drug development. This screening service shall be performed on a commercial basis. The milestone of this proposal, to be achieved within 18 months, is the validation of the in vivo platform for testing the effects of new potential diabetes medicines on human β-cell function and survival in normal and diabetic mice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Nanoparticles with switchable shells for virus sensing and inhibition' to be submitted under Horizon 2020.

assistant: **Abstract**

This proposal concerns Reversible Self-assembled Monolayers (rSAMs) as dynamic nanoparticle shells for multivalent interactions at biointerfaces. Current drug design and diagnostics are exploring the multivalency concept, i.e. binding of biological targets via multiple weak interactions. In contrast to classical drug design relying on high-affinity inhibitors, thisrelies on dendritic architectures featuring a high density of ligands, e.g. saccharides, capable of simultaneously interacting with biointerfacial receptors. This strategy can be used to inhibit the virus entry by blocking the receptor at the early stages of infection and the concept is being explored as antiviral drugs and in virus sensing. However, in current systems ligands are covalently fixed on the particle surface. This prevents control over the ligand distribution and composition which compromises selectivity and affinity of the interactions. rSAMs are pH-switchable versions of thiol-SAMs. They are tunable with respect to the nature of the head group and layer order and stability while featuring pH responsiveness and the dynamic nature of non-covalently build assemblies e.g. lipid bilayers. Ligand decorated rSAMs therefore feature strongly enhanced affinities for multivalent targets. The main aims of this proposal are:1) to investigate the use of rSAMs as dynamic nanoparticle shells for multivalent inhibition of viruses and 2) to assess suchsystems as nanoplasmonic sensors for antibody-free ultrasensitive, robust and rapid in situ virus detection.Under 1) we will select model pathogens, e.g. Ebola and prepare a series of saccharide terminated amidines for the first generation dynamic shell nanoparticles.Their efficiency will be assessed in infection assays using artificial virus particlesUnder 2) we wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Photopharmacology: From Academia toward the Clinic.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

''Photopharmacology: from academia toward the clinic'' aims at the development of our platform technology from an academically emerging field towards a technology which has proven clinical applicability. Within this project novel photopharmacological targets will be evaluated and investigated. Additionally, in vivo proof of concept will be generated to make our technology ready for further clinical validation.


**Keywords:** Photopharmacology, Drug development, Photoswitches, Molecular Motors, Light, Azobenzene, Cancer, Antimicrobials, Synthetic Chemistry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Obstruction DEtection Sensor for Surveillance on Aircraft' (ODESSA).

assistant: **Concept**

Mid-air, near mid-air, and-on ground collisions are one of the most important cause of accident in general aviation. For this reason, engineering an affordable sensor helping pilots in preventing it could be very important in order to prevent accidents. Present sensors, indeed, are very expensive and cannot be affordable for small aircraft and helicopters.The idea of ODESSA (Obstruction DEtection Sensor for Surveillance on Aircraft) is to provide a small, light, and low-cost sensor (comparing it to the present ones) that could be installed on both airplanes and helicopters, but on unmanned aerial vehicles too. This is possible adopting the modular avionics concepts of on-board system independency, reducing maintenance efforts, granting different platform applicability.Using millimetric radar, learning techniques from automotive worlds, gives different advantages. One is that automotive technologies are well tested and reliable. These solutions are small, light and cheap too.Inheriting characteristics from automotive technologies, ODESSA allows to detect small object, increasing on-ground safety during handling and taxing. An issue of these mission phases is the possibility of collision not only with aircraft (that could be minimized by using new generation ADS-B systems), but with other kinds of object (as pushbacks, cars, signals, personnel, birds…) not well detectable from aircraft unless mounting the terrestrial version of ADS-B (that requests the adaptation of the whole airport infrastructure).ODESSA system makes possible that safety in landing and ground procedures is independent from different component of the airport system, granting danger acknowledgment in different sceneries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of systems to improve phytoremediation of metal contaminated soils through improved phytoaccumulation' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The widespread moderate levels of metal pollution, clearly above European standards, have led to limitations in landuse, and soil remediation is needed. Phytoremediation, the use of plants for cleaning metal-polluted soils, is of low cost, environmentally sound and equally protective of human health and the environment, and should be considered a good alternative to current techniques. Natural plants have serious limitations. The present state of knowledge on the mechanisms of metal tolerance, uptake and accumulation is limited and does not allow construction of designer plants for remediation. Metal-responsive genes will be characterized (functional genomic) from metal-hyperaccumulatingThlaspi and expressed in yeast, Arabidopsis and higher biomass producing tobacco and Basic. Entophytes andrhizosphere microorganisms will be isolated, modified and tested, in combination with the plant, for improved metalaccumulation. GM and non-GM approaches will be compared in laboratory and greenhouse studies. Risk assessment of the approach will form a central core of the studies. The goal is to develop systems for improved phytoaccumulation of metals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Structure function analysis of human killer-cell activatory receptor for mhc class i molecules'.

assistant: **Objectives**

Research objectives and content NK cells express on their surface receptors for MHC class I molecules that do not only function as Inhibitory receptors. In fact, crosslinking of these MHC specific NK receptors (Killer-cell Activatory Receptors: KAR), results in early events, such as Ca2+ mobilization and late effector functions, such as induction of cytotoxicity and cytokine production. The aim of my proposal is to investigate the mechanisms that regulate the activation of NK cells through KAR. In particular, I will attempt to perform the molecular cloning of KARAP (KAR-Associated Proteins) that are likely involved in signal transduction of KAR. Subsequently, the elucidation of KARAP structure will allow the study of KARAP functions. Training content (objective, benefit and expected impact) My project is part of a collaboration on NK receptors for MHC class I molecules between the laboratory directed by Prof. A. Moretta in Italy and the one directed by Prof. E. Vivier in France. Since The Centre d'Immunologie de Marseille-Luminy has a long experience in signal transduction, I will easily conduct my project and I will be able to learn a highly specialized techniques than can be very useful for my professional experience.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Harnessing the Market Potential of Single-Atom Catalysts through Next-Generation Large-Scale Synthesis' (CATSYNEX).

assistant: **Concept**

The CATSYNEX project, born from the ERC-StG SAC_2.0 project, addresses the pressing need for scalable production of single-atom catalysts to revolutionize industrial catalysis.While homogeneous catalysts dominate pharmaceutical synthesis due to their precision, they suffer from recovery, instability, and cost issues. Heterogeneous catalysts offer easier separation but struggle with lower degree of selectivity and activity when used in pharmaceutical reactions.Single-atom catalysts bridge this gap, offering atomically precise control during catalyst formulation, enhanced catalyst stability, higher turnover frequencies, and reduced material costs. However, current synthesis methods limit single-atom catalysts to laboratory scale. CATSYNEX aims to change this by developing scalable SAC production methods.The scientific validation involves optimizing SAC synthesis for uniform dispersion and high catalytic activity, ensuring reproducibility across batches and scaling to industrial quantities. Catalytic performance will be tested against traditional catalysts to showcase SAC superiority at different scales (from mg to kg), and over multiple catalytic cycles. Business validation includes analyzing IP landscape, regulatory framework, market appeal, and manufacturing economics.Through CATSYNEX, SACs are poised to become valuable tools for various chemical industries, driving innovation by making pharmaceutical synthesis more efficient, more sustainable, and cost-effective, and addressing some of the pressing critical challenges of the 21st-century manufacturing processes.