RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'A Grand Unified Theory of Decidability in Logic-Based Knowledge Representation' under Horizon 2020.

assistant: **Concept**

Logic-based knowledge representation (KR) constitutes a vital area of IT. The field  inspires and guides scientific and technological developments enabling intelligent management of large and complex knowledge resources. Elaborate languages for specifying knowledge (so-called ontology languages) and querying it have been defined and standardized. Algorithms for automated reasoning and intelligent querying over knowledge resources are being developed, implemented and practically deployed on a wide scale. Thereby, decidability investigations play a pivotal role to characterize what reasoning or querying tasks are at all computationally solvable. Past decades have seen a proliferation of new decidable formalisms for KR, dominated by two major paradigms: description logics and rule-based approaches, most notably existential rules. Recently, these research lines have started to converge and first progress has been made toward identifying commonalities among the various formalisms. Still, the underlying principles for establishing their decidability remain disparate, ranging from proof-theoretic notions to model-theoretic ones. DeciGUT will accomplish a major breakthrough in the field by establishing a ""Grand Unified Theory"" of decidability. We will provide a novel, powerful model-theoretic criterion inspired by advanced graph-theoretic notions. We will prove that the criterion indeed ensures decidability and that it subsumes most of (if not all) currently known decidable formalisms in the KR field.We will exploit our results toward the definition of novel decidable KR languages of unprecedented expressivity. We will ultimately extend our framework to encompass more advanced KR features beyond standard first order logic such as counting and non-monotonic aspects.Our researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional profiling and therapeutic tolerization of macrophages in type 1 diabetes' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Type 1 diabetes (T1D) is a chronic condition that results from the specific destruction of pancreatic beta cells by the immune system. As a consequence, affected individuals can no longer regulate their blood sugar levels and become dependent on glucose monitoring and insulin injections. Despite careful disease management, serious neuronal and vascular long-term complications can often not be avoided. This debilitating disease is an important and growing public health concern in Europe: it is predicted that by 2020 approximately 24.400 individuals will be diagnosed with T1D annually.It is thought that T cells are the principal effector subset that drives beta cell decay within the islets of Langerhans. Inflammatory islet lesions (‘insulitis’) are predominantly populated by T cells and T cell species reactive against pancreatic islet antigens can be found in the blood around disease onset.  The importance of innate immunity and in particular macrophages has historically attracted a minor degree of attention. Nevertheless, macrophages are abundantly represented within islet infiltrates from patients and are required for disease manifestation in animal models. Recent evidence from clinical trials has exposed the failure of strategies for inducing peripheral T cell tolerance, most recently with anti-CD3 antibody therapy. While genetically defined thymic escape and consequent T cell autoimmunity may be very important in type 1 diabetes, we hypothesize that T cell-mediated recruitment and activation of macrophages represents a secondary yet significant pathological pathway. The research outlined in this application is designed to determine the functional phenotype of islet-infiltrating macrophages around diagnosis, their role in antigen shuttling to the pancreatic lymph nodes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intelligent Glass: Affordable and Maintenance-Free Solution for Transforming Homes and Working Spaces' under Horizon 2020.

assistant: **Concept**

Most people spend about 90% of their days indoors, especially in cities. Vast majority of commercial and residentialbuildings’ windows do not transmit enough natural light to homes and offices. Reduced exposure to natural light results inHealth (increased blood pressure, stress and anxiety, weaker immune system, worse sleeping cycle), and Workplace(decreased focus, reduced productivity, worse task progression, reduced energy level) issues. Increasing window surfacecomes with a cost. On the other side, functionality of spaces is one-sided – you can't have a shared workspace and privateoffice in the same room, and you can't have bathroom without walls separating it from living room. Or can you?Intelligent Glass is a patentable hi-tech glass panel that turns around the way people use natural sunlight in their homes/workspaces. It enables transparency adjusting, creating multi-functional spaces, has intelligent automation options, and cutsdown energy costs. Also, its innovative in-house-built technology brings heat and UV protection, dimmability, usage astouch- or presentation screen, and allows accessible end-user price for luxurious design.The company envisages commercial and residence buildings as key targets, while also offering Intelligent Glass to internalrenovations of apartments and offices. With inbound marketing serving increasing demand, outbound direct sales andindustry events channels, Intelligent Glass can reach 600 clients and realize 4,4 mio EUR revenue in 5 years. Willingness tobuy was already validated in projects with house builders, and individual installations on Slovenian and Croatian market.In feasibility study we want to (i) analyze further product development requirements and prepare its development plan, (ii)assess market demand, commercialization
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'European training network for developing Smart neurOmonitoring solutions to support PRecision medicine in Acute central Nervous Injury'.

assistant: **Innovation**

In traumatic brain/spinal cord injury and stroke – major causes of death and disability -, progress has come from monitored intensive care and swift action upon detection of secondary insults. Although it is possible to monitor intracranial pressure, the brain & spinal cord still behave as a black box. Current measurable signals only roughly represent ongoing pathophysiological processes, and dynamic insults (eg impaired autoregulation and neurovascular unit dysfunction) cannot be reliably monitored. As a result, no therapeutic action has been shown to be beneficial in randomized patient trials. The project goal is to prepare novel dynamic insult monitoring technologies and to develop improved decision support by integrating disease models and insult/treatment ontologies into smart multimodality monitor software. A parallel goal is to unite high level expertise in clinical, biomedical, statistical and engineering sciences into one network to boost the next generation of researchers to substantially advance the field of neuromonitoring. The network includes 3 relevant animal models and access to large (multi)center patient databases with injury, treatment & outcome data (eg Center-TBI). Direct autoregulation visualization in the cranial window piglet model will be elaborated to improve circulation models and relations with measurable high resolution signals to develop a real-time autoregulation monitor. These metrics will be associated with spreading depolarizations, vasospasm, ischemia and brain function in the rodent stroke models. The models and monitor technology are highly transferrable to patient care. Patient data will be used to build multidimensional statistical disease models. Insult and treatment ontologies will be developed in parallel with insult prediction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stochastic reserving based upon mathematical statistics' (RESERVING) under Seventh Framework.

assistant: **Objectives**

The aim of my proposal is to develop a coherent methodology based on classical mathematical statistics for the important area of reserving, transforming it into state-of-the-art mathematical statistics. In doing this, I will use my academic knowledge of modern mathematical statistics, in particular my extended experience in modern smoothing theory.The objectives are:- To develop models based on reported numbers of claims and aggregated claim payments, which provide better insights into the underlying drivers of the claims data- To investigate the use of external data to stabilise the predictions of claims liabilities- To incorporate models which allow for claims inflation in calendar, development year and underwriting year direction- To develop new bootstrap methodologies in order to obtain predictive distributions- Finally to transfer all the above results into a continuous data setting based on structured smoothing.Everything I proposed in this Fellowship is directly linked to what practical actuaries are doing today. They can follow step by step how their current reserves are being changed when adding more and more features of our new methodologies. One can therefore understand the difference between the innovative reserving methods of this project and current methods. It is expected that the suggested working stream will lead to popular methods with a good chance of quickly catching on in the industry. One major global insurer is already advocating such work in light of the increasing regulatory pressure on improved reserving methodologies formulated via Solvency II and it is hoped more will follow when the work develops and gets more widely accessible to practitioners.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Functional genomics of transcriptional regulation in crowded media'.

assistant: **Innovation**

The present proposal concerns a return and reintegration grant for Dr Silvia Zorrilla, a current Spanish EIF fellow in the Centre de Biochimie Structurale in Montpellier (France), in order to continue doing research in the Instituto de Química Física Rocasolano (CSIC, Madrid), where she carried out her doctoral thesis, with the final objective of being permanently reincorporated there. During the EIF project, biophysical studies were conducted in parallel with structural determinations and microbiological studies by our collaborators, to better understand the function of several relatively unknown regulatory proteins from Bacillus subtilis identified in a previous European grant.In the present project we propose to go farther in the understanding of  the conditional interactions of the transcriptional regulators studied during the EIF training period, by conducting biophysical experiments in macromolecular crowding conditions mimicking the crowded nature inherent to all living systems. The methodology applied during the EIF research to the study of transcriptional regulation in the model bacterium will also be extended to some PPAR nuclear receptors, a family of eukaryotic transcriptional regulators implicated in a number of major diseases including cancer. PPAR interactions with DNA and ligands will be studied in vitro, in diluted as well as in macromolecular crowding conditions, but also in vivo using state-of-the-art single molecule fluorescence spectroscopy approaches.The proposed research will be carried out in collaboration with groups of experts from the CSIC (Spain) and the CBS (France). On a broader level, our investigation will involve the development of single-molecule fluorescence-based homogeneous assays, adapted to be performed in crowded conditions, which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Internet of Things Air Tester as a new standards based wearable monitoring station for personalized indoor and outdoor air quality real-time assessment' under Horizon 2020.

assistant: **Concept**

We are a Portuguese SME, which provides Indoor Air Quality (IAQ) and Sick Building Syndrome (SBS) audits, andEnvironmental analysis services. We have been working in the development of a disruptive way to improve the monitoringof indoor and outdoor air quality using the Citizen Observatories model as the strategic approach for our business. To thisend we aim to prototype, test and commercialise an IoT wearable air quality monitoring system for both professional auditorsand citizens.IAQ audits are a key tool to prevent health risks and spur productivity, while supporting energy efficient measures. AuditingIAQ involves various unknown variables which impact on the cost, the time and the effectiveness of the audit.We have a clear and disruptive business opportunity, as an IoT IAQ system that would enable easy and fast monitoring ofphysico-chemical IAQ indicators in whole buildings using its own occupants as mobile monitoring stations, will increase theefficiency and effectiveness of audits at a lower cost.habITAT addresses priorities of the EC aligned within Europe 2020 Flagship Initiatives , the Environment ActionProgramme , the Eco-innovation Action Plan and the EU Expert Group on Indoor Air Quality.Objectives of the feasibility study: 1) Examine the technical feasibility of the solution to achieve a good problem-solution fitthat will enable jump-start product adoption, and bridge innovators with early adopters; 2) Examine the commercial feasibilityto achieve a good product-market fit that will enable bridging early adopters with early majority in the product life cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Memory and learning in Alzheimer's disease: involvement of amyloid precursor protein and tau in function and dysfunction of the hippocampal formation' in the context of a Sixth Framework call.

assistant: **Objectives**

Alzheimer's disease (AD) is the most common cause of dementia in the Western world, accounting for up to 50-60% of all late-onset dementia cases. Neuropathologically, AD is characterised by abnormal accumulations of intracellular neurofibrillary tangles and extra-cellular amyloid plaques in the brain; additional features are deficits in multiple neurotransmitter signalling systems and synaptic loss. The objectives of this proposal are to study transgenic mouse models to define molecular mechanisms leading to amyloid and tau pathology and examine at what level they impact the normal signalling pathways of cognition.Our basic aims are to(i) investigate proliferation, neural differentiation, cell renewal, survival and synaptic plasticity in(ii) highly relevant single or multiple transgenic AD mouse models with amyloidoses and tauopathies,(iii) assess cognition, learning, memory and behaviour in the same mouse models and (iv) devise therapies to improve any deficiencies.We expect the research outlined in this proposal to:(i) increase our understanding of amyloid and tau pathology, enabling us(ii) to explore diagnostic biomarkers and drug targets for AD and(iii) to contribute to the fundamental knowledge of neuro-degenerative disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cross-lingual Knowledge Extraction' (X-Like) targeting Seventh Framework.

assistant: **Abstract**

The goal of the X-LIKE project is to develop technology to monitor and aggregate knowledge that is currently spread across global mainstream and social media, and to enable cross-lingual services for publishers, media monitoring and business intelligence.In terms of research contributions, the aim is to combine scientific insights from several scientific areas to contribute in the area of cross-lingual text understanding. By combining modern computational linguistics, machine learning, text mining and semantic technologies we plan to deal with the following two key open research problems:- to extract and integrate formal knowledge from multilingual texts with cross-lingual knowledge bases, and- to adapt linguistic techniques and crowdsourcing to deal with irregularities in informal language used primarily in social media.As an interlingua, knowledge resources from Linked Open Data cloud (http://linkeddata.org/) will be used with special focus on general common sense knowledge base CycKB (http://www.cyc.com/). For the languages where no required linguistic resources will be available, we will use a probabilistic interlingua representation trained from a comparable corpus drawn from the Wikipedia.The solution will be applied on two case studies, both from the area of news. For the Bloomberg case study the domain will be financial news, while for the Slovenian Press Agency we will deal with general news. The technology developed in the project will be used to introduce cross-lingual and information from social media in services for publishers and end-users in the area of summarization, contextualization, personalization, and plagiarism detection. Special attention will be paid to analysing news reporting bias from multilingual sources. The developed technology will be lang
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Socialism and leftist Catholicism in France and Italy (1956-1972)' under Seventh Framework.

assistant: **Concept**

The SOCIALCATH research project deals with the intercultural connection between Socialism and Catholicism in two cases in which this meeting was very evident: the French ""Parti Socialiste Unifié"" (PSU) and the Italian ""Partito Socialista Italiano di Unità Proletaria"" (PSIUP).PSU and PSIUP put together Socialists and Catholics who did not accept the main strategy of their respective political families. PSU and PSIUP wanted represent a radically democratic form of modernity, giving great attention to social ferments and to defend all discriminated or under-represented categories: workers, women and young people. PSU and PSIUP were libertarian and they refused the hierarchical structures of a mass party, adopting a fluid organisation totally open to different cultural models.The political relationship between PSU and PSIUP, their ideological exchanges and the contacts between their members have never been explored within a scientific context. The SOCIALCATH project aims to fill this scientific gap, bringing to light many unedited documents. The interdisciplinary approach, the multi-methodological analysis and the comparative nature of the SOCIALCATH project are all new instruments to be used in these arguments.The SOCIALCATH project aims to reach three main objectives:1. to describe the meeting between opposite cultural areas such as Socialism and Catholicism, in order to support the policies for intercultural dialogue promoted by the EU and other international organisations such as UNESCO.2. to highlight alternative aspects of Socialist and Catholic cultures, in order to discover the anti-dogmatic spirit of the 60s and its today's inheritance in the collective European conscience.3. to explore the relationship between the PSU and PSIUP's political class and the new so