RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Improving treatment efficacy in hypertension by biomarker-guided personalised decision support' (HT-ADVANCE).

assistant: **Concept**

In HT-ADVANCE we aim to revolutionise personalised management of arterial hypertension (HT) by using multi-omics (MOMICS) stratification biomarkers as companion diagnostics for the prescription of existing drugs. HT is the most important global risk factor for death and morbidity but is uncontrolled in more than 50% of patients. Causes of treatment failure include lack of identification of secondary forms such as endocrine hypertension (EHT) which can be curable by specific therapy.  In addition, there is variable response to individual drugs and trial-and-error treatment leads to poor HT control and frustration for both patients and clinicians.The objective of HT-ADVANCE is to validate two multicomponent stratification biomarkers in patients with HT in order to i) identify patients with EHT, and ii) predict response to treatment in patients with primary hypertension.  The hypothesis is that MOMICS biomarkers reflect specific forms of hypertension and susceptibility to specific drugs. To this end, we will run three clinical trials (HT-ENDO, HT-TREAT and HT-PREDICT) and apply machine learning techniques to integrate the genetic, genomic and metabolomic features that constitute the MOMICS biomarkers in order to generate accurate diagnostic and therapeutic response predictions for clinicians. We will also perform economic evaluation of the use of MOMICS for the treatment of HT, produce ethical and legal recommendations for clinical decision making, and develop a plan for their implementation as companion diagnostics.The study will be conducted by several HT Centres of Excellence and will build on the success of the ENSAT-HT project that has established methods and pipelines for integrating datasets derived from multiple platforms.  We expect that HT-ADVANCE will provide a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Translation of novel Biomarkers for Bladder Cancer for clinical outcome prediction' (TRANSBIOBC), addressing dissemination and exploitation.

assistant: **Impact**

Currently, clinical diagnosis and monitoring of bladder cancer (BC) relies on invasive, highly costly cystoscopy. Additionally, due to high recurrence rates BC treatment is associated with frequent follow-up of patients, making BC one of the most costly types of cancer in terms of management cost. Thus there is a clear clinical need for the development of new approaches for early detection of recurrence and progression.Our proposal is based on the identification of novel biomarkers (BM) for BC recurrence and progression in urine and powerful technological platforms as extensive foreground work of the involved partners in the framework of FP7 EU projects DECanBio and GENINCA. The objective of TransBioBC is to translate this foreground work in the field of BC and to specifically employ the involved technologies (CE-MS and micro-ELISA), represented by the participating SMEs, for the development of non-invasive urine tests for routine monitoring of BC recurrence and progression. Our project uniquely integrates leading BC clinical experts with experts on proteome analysis and high throughput immunoassay development in an implementation-oriented workflow. Strict monitoring of assay analytical performance, and properly collected and well characterized clinical samples from existing sufficiently powered BC cohorts are combined with in-depth knowledge of regulatory requirements, analysis approaches to define added value and well designed business plans including multi-stakeholder dissemination and exploitation plans.Collectively, TransBioBC will provide strong evidence for utility of the new BM directly in BC clinical management and as a secondary aim for usage in clinical trials and drug development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'LICHen population gENetics and genOMICS - Gene expression, neutral and adaptive genetic variation in natural populations of Peltigera membranacea""', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A major question regarding climate change is whether species can respond to rapid climate change and avoid extinction. Here, we address this question by studying neutral and adaptive genetic variation in populations of the lichen-forming fungus Peltigera membranacea. Based on existing genome data (host lab), we identified hundreds of microsatellites (SSR) and 119 genes involved in fungal environmental stress responsea (ESR). Landscape-level patterns of gene movement will be studied with SSR markers, offering valuable insight on whether the species is likely to spread to sites with suitable conditions under climate change (landscape genetics). An experiment will shed light on whether gene expression differs when thalli are grown at high and low temperatures (experimental transcriptomics). The ESR genes will be investigated with Next Generation Sequencing to identify SNPs with an association to environmental variables to infer the species’ potential to adapt to the environment based on standing genetic variation within populations (landscape genomics). The results will clarify the response of lichen fungi to climate change, both in terms of the species’ potential for adaptation, tolerance of changed conditions, and spread of individuals to new sites.By performing this fascinating research, the fellow will have the valuable opportunity to receive high quality training in bioinformatics including analysis of transcriptomes, genome annotation, and training in laboratory skills, i.e. isolation of high-quality mRNA and preparation of libraries for Solexa sequencing. A long-term collaboration will be established between the laboratories in Switzerland and Iceland, as a major step in building a pan-European researcher team working on population genomics of lichens (LICHENOMICS).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Reconfigurability using inversely designed metasurfaces', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The evolving needs of society demand advanced control of electromagnetic waves. At the forefront of science are metasurfaces—ultrathin engineered layers with tailored electromagnetic responses. While traditional metasurfaces are statically predesigned, current research is shifting toward reconfigurable metasurfaces, which can dynamically adjust their properties after fabrication. This capability expands their potential for real-world applications across a range of industries. Despite their promise, most reconfigurable metasurfaces rely on the element-by-element tunability of large arrays that require high energy consumption, complex implementation, and high costs. MetaTune addresses these challenges by training the next generation of researchers to develop a new class of reconfigurable metasurfaces combining simplicity of implementation, multifunctionality, and industrial viability. These metasurfaces will feature unified tunability mechanisms, reducing complexity and energy usage, while incorporating innovative materials for enhanced adaptability, robustness, and endurance. Furthermore, the project will pioneer cost-effective fabrication techniques, ensuring compatibility with large-scale production.The program adopts a multidisciplinary approach, conducting application-driven research in four high-impact domains: communication systems, thermal management, sensing, and imaging. Beyond scientific training, participants will gain comprehensive industry exposure and develop transversal skills, preparing them for diverse career pathways in academia and industry.By tackling these critical technological challenges, MetaTune not only advances fundamental knowledge in physics and engineering but also bridges the gap between laboratory research and industrial implementation. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Innovative insight into the endogenous kallikrein-kinin system in tissue in health and disease state', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Cardiovascular diseases, cancer, and sepsis are the leading causes of death worldwide. In all of them, a strong involvement of the endogenous kallikrein-kinin system (KKS) is postulated. However, the KKS is only rudimentarily understood, which is also reflected by the large proportion of developed drugs showing insufficient efficacy. The KKS is a 2-arm cascade that is present in both the blood as well as the tissue and its actions are mediated by the so-called kinins. Comprehensive insight into the cascade is greatly hindered by the lack of appropriate bioanalytical techniques. While the fellow has recently developed an innovative mass spectrometric method for the plasma KKS and applied in clinical studies, the tissue KKS has not yet been investigated, although the physiological action is likely exerted only in tissue. The advances in mass spectrometric imaging are currently used for metabolomics or mapping of biomolecules in tissue, but appear to be highly promising also for targeted kinin detection in the tissue KKS. The fellow with his key expertise in targeted mass spectrometric kinin quantification will use different mass spectrometric imaging techniques (DESI, MALDI, MasSpec Pen) to evaluate the tissue KKS. Hence, the TIKKS project is to first time study the presence, distribution, metabolism and overall profile of kinins in different (diseased) tissues by mass spectrometric imaging. For this purpose, various malignant tissues are examined as a main objective and subsequently extended to cardiovascular diseases and angioedema. This innovative approach will allow the fellow to uniquely investigate physiology and pathophysiology across both arms of the KKS (tissue & plasma) and therefore strengthen him on his path to his own professorship. The combined power of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geography and economy of the imperial properties in the Roman World (from Augustus to Diocletian).' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

PATRIMONIVM aims at conducting the first comprehensive and multidisciplinary socio-economic study of the properties of the Roman emperors from Octavian/Augustus to Diocletian (44 BC – AD 284) using a complete documentary base for the entire Roman world. Imperial properties were extended throughout the empire and included residences, cultivated land, pastureland, woods, mines, quarries, luxury items and slaves. This immense richness was a key element for the maintenance of the position of supreme power, since the emperor could use it to carry out all sort of public expenditure and to confer benefactions to individuals and communities. Moreover, large imperial possessions (vast landed estates, quarries) had relevant local economic repercussions. Since their owner was both the head of the empire and a global economic player, we can trace a tendency to trans-regional uniformity in the patterns of exploitation and a positive effect on the economic and, in a certain way, cultural integration of peripheral areas. No major survey of the available documentation has been produced since the beginning of the 20th century and many questions about the acquisition and use of the properties remain unanswered. The project aims at filling this gap creating a powerful online relational database of all published sources; every record will contain geodata and will be related to separate databases of all known persons (administrators, peasants etc.), regions and bibliographic references. A multidisciplinary and comparative study, developed through the project’s rich scientific activity, will allow to understand the role of the properties as a structuring factor of Roman economy and as a vector of human mobility and socio-cultural transformation. Innovative hypotheses on imperial investments,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cancer and other diseases are driven by genomic alterations initiated by DNA breaks. Within our genomes, some regions are particularly prone to breakage, and these are known as common fragile sites (CFSs). CFSs are present in every person and are frequently sites of oncogenic chromosomal rearrangements. Intriguingly, despite their fragility, many CFSs are well conserved through evolution, suggesting that these regions have important physiological functions that remain elusive. My previous background in genome editing, proteomics and replication-born DNA damage has given me the tools to propose an ambitious and comprehensive plan that tackles fundamental questions on the biology of CFSs. First, we will perform a systematic analysis of the function of CFSs. Most of the CFSs contain very large genes, which has made technically difficult to dissect whether the CFS role is due to the locus itself or to the encoded gene product. However, the emergence of the CRISPR/Cas9 technology now enables the study of CFSs on a more systematic basis. We will pioneer the engineering of mammalian models harbouring large deletions at CFS loci to investigate their physiological functions at the cellular and organism levels. For those CFSs that contain genes, the cDNAs will be re-introduced at a distal locus. Using this strategy, we will be able to achieve the first comprehensive characterization of CFS roles. Second, we will develop novel targeted approaches to interrogate the chromatin-bound proteome of CFSs and its dynamics during DNA replication. Finally, and given that CFS fragility is influenced both by cell cycle checkpoints and dNTP availability, we will use mouse models to study the impact of ATR/CHK1 pathway and dNTP levels on CFS instability and cancer. Taken together, I propose an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Functional Biointerface Elements via Biomicrofabrication'.

assistant: **Objectives**

Imagine in the future, bionic devices that can merge device and biology which can perform molecular sensing, simulate the functions of grown-organs in the lab, or even replace or improve parts of the organ as smart implants? Such bionic devices is set to transform a number of emerging fields, including synthetic biotechnology, regenerative medicine, and human-machine interfaces. Merging biology and man-made devices also mean that materials of vastly different properties need to be seamlessly integrated. One of the promising strategies to manufacture these devices is through 3D printing, which can structure different materials into functional devices, and simultaneously intertwining with biological matters. However, the requirement for biocompatibility, miniaturisation, portability and high performance in bionic devices pushes the current limit for micro- nanoscale 3D printing.  This proposal aims to develop a new multi-material, cross-length scale biofabrication platform, with specific focus in making future smart bionic devices. In particular, a new mechanism is proposed to smoothly interface diverse classes of materials, such that an active device component can be ‘shrunk’ into a single small fibre. This mechanism utilises the polymeric materials’ flow property under applied tensile forces, and their abilities to combine with other classes of materials, such as semi-conductors and metals to impart further functionalities. This smart device fibre can be custom-made to perform different tasks, such as light emission or energy harvesting, to bridge 3D bioprinting for the future creation of high performance, compact, and cell-friendly bionic and medical devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Exploring costs and benefits of haccp : a pilot study in the dairy and meat products industry in the european union' (COSTS-BENEFITS-HACCP).

assistant: **Innovation**

Since 1995 the Directive 93/43/EEC prescribes the application of HACCP principles in food production. However, despite the major importance of food safety, there is a fundamental lack of information on the economic impact of this directive. This project aims to study costs and benefits of HACCP, including the impact of HACCP on public health. Due to the complexity of the issue, we propose to start with a pilot study, limited to dairy and meat products industry in NL, UK and I. Information will be obtained at two levels: production chain and public health. Integration of these results will result in recommendations at the levels of EU member states and industry for regulation and supporting measures, and in recommendations for an effective and efficient approach for a more comprehensive project on costs and benefits of HACCP, covering major parts of the food industry in EU member states.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European French Resarcher's Night 2008' (EFRENI), addressing dissemination and exploitation.

assistant: **Impact**

For the fourth year of the European demonstration the Night of the Researchers, 13 French partners met to propose projects having to bring the citizen and the researcher to be met. The diversity of the operators will offer to the visitors a diversity of proposal, participant in a discovery of this individual who is the researcher. We will find ourselves in the cities like Strasbourg, Mulhouse, Besancon, Dijon, Lille, Rennes, Bordeaux, Toulouse, Angers, Montpellier, Nimes, Brest, Nice and Paris and the area Ile de France. For this edition 2008, each partner will offer a festive demonstration. The importance will be put on the meeting of the public with the researchers present. It will be produced by a setting in scene particular, an accompaniment of the visitor during the evening, the use of particular places and specific in order to produce a real event participative and opened with the greatest number. During these various evenings, the goal is to lead the researcher to be an actor of the demonstration. To present themselves as being a citizen, and to identify the magic which its work can cause. It is in the sense that the aesthetic approach of the evenings will be an essential point, in order to immerse the visitor in an environment enabling him to plunge itself in an unknown universe in its eyes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AI accelerating Cities transition to carbon neutrality' to be submitted under Horizon 2020.

assistant: **Abstract**

AI4Cities brings together the leading European cities in the intersection of ‘Smart Cities’ and Greenhouse Gas (GHG) emissions reduction, in order to speed up and steer the creation of new breakthrough solutions in how Artificial Intelligence (AI) can support cities’ strategic plans to become Carbon Neutral. Right now is the time to direct AI research/innovation towards the societal needs -- to assign detailed, pragmatic, solvable ‘missions’ from the cities’ climate action plans to AI developers. Through these missions, this project will create breakthrough, scalable, European solutions for these specific needs, and thus lead to immediate, concrete and measurable emissions savings, but more importantly, give examples on how to create impact and better future, for the whole of the AI community as well as all the European cities and citizens. On one hand, the opportunity window for European AI leadership is closing fast in the competition between solutions coming from the US and China - what kind of AI solutions govern us in the future is of great policy interest for Europe. On the other hand, urban emission reduction ambitions in most of the cities are set up so high that many of them are not realistically achievable without exploiting best-in-class ICT technologies. While cities are different, the largest opportunities for emission reduction in European cities are very similar. The highest common reduction targets in most cities’ climate action plans are in transport and in buildings’ energy use. As an example, in Helsinki, the production of Electricity and Heating accounts for 71% of GHG emissions; urban transportation and traffic account for 24%. Combined, these two sectors total 95% of Helsinki’s total carbon footprint.The purpose of this PCP is to support Cities’ tr