RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Impact of Natural Killer Cells on Fetal and Placental Development' (2007-2013).

assistant: **Concept**

In this proposal I wish to test the hypothesis that immune cells of the Natural Killer (NK) lineage use similar mechanisms to regulate both invasive placental cells and invasive cancer cells. Trophoblast cells and NK cells appear to come into close contact at the fetal-maternal interface during early pregnancy both in human and mice. Trophoblast cells indeed invade deep into the uterus while maternal NK cells accumulate adjacent to the invading trophoblast. These immune cells are a unique population and are known as uterine NK (uNK) cells. The interactions between trophoblast and uNK cells most likely influence the tissue remodelling that results in increased blood flow necessary for fetal growth. Thus, these interactions are key to successful reproduction but the molecular mechanisms are unknown and are the focus of this proposal. Like human uNK cells, also mouse uNK cells express activating receptors, such as the Natural Cytotoxicity Receptor NKp46, which is coded by the Ncr1 gene and is conserved in human, mice and many other species. NKp46 is a key receptor to recognise cancer cells. The host laboratory (lead by F Colucci) has shown that NKp46-deficient mice are more prone to metastatic melanoma (JCI, 2009) and that mouse trophoblast cells may express NKp46 ligands (unpublished). Considering the invasive properties of trophoblast, the question we wish to address is whether NKp46 controls the extent of trophoblast invasion, thereby affecting spiral arteries remodelling and fetal-placental growth. To address this question, we will compare trophoblast invasion, spiral artery modification and fetal-placental growth in NKp46-sufficient and NKp46-deficient transgenic mice.The understanding of the molecular interactions between uNK cells and trophoblast will help define th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photonic System Engineering with Microcombs' in the context of a Horizon Europe call.

assistant: **Objectives**

Optical frequency combs are fascinating photonic devices for realizing modern applications that rely on precision frequency synthesis and metrology. Today, microcombs offer the prospect of attaining, in a single chip-scale form-factor, an optical frequency comb with outstanding performance in terms of line spacing and bandwidth coverage. With microcombs, some proof of principle, lab-based system-level demonstrations have been realized, but these make use of large bulk components and instrumentation that prevent the large-scale deployment of this technology in mass-market applications. The overall ambition of this doctoral network is to provide the scientific and training necessary to bridge the gap between proof-of-principle applications and deployment of this disruptive technology. The network brings together experts from academia and industrial leaders in microresonator frequency combs, heterogeneous integration, packaging technology, and nonlinear physics, while covering a wealth of emerging applications: from quantum information processing to biophotonics. The collaborative science is embedded in a meaningful, comprehensive and tailored-made training program that covers crucial aspects in diversity, digital science, entrepreneurship and innovation. This network will catalyze the career of 12 doctoral candidates who will pave the way for novel scientific endeavors and deploy this technology in mass-market applications, from datacenter interconnects to lidar in self-driving cars.


**Keywords:** frequency comb; silicon photonics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Innovative tools for the detection and mitigation of CBRN related contamination events of drinking water' in the context of a Seventh Framework call.

assistant: **Objectives**

SAFEWATER will develop an affordable global generic solution for the detection and management of drinking water crises resulting from CBRN contamination. SAFEWATER addresses the key drinking water incident management challenges at large, and in particular, the current shortcomings related to the contamination of water networks by CBRN agents - the lack of effective detection capacities, contamination warning systems, and decision support and management tools.SAFEWATER will start from best-of-breed technologies, including an EPA challenge winning event detection system. From this, the project will develop a dedicated DSS for the real-time support of decision makers, which comprises cutting-edge algorithms based on:•Improved water management models for the detection of abnormal behaviour in drinking water systems; as well as the prompt treatment of data from various sources, improving contamination alert systems of large water drinking systems•Result interpretation models to enable the real-time ranking of the severity of alerts and for the prompt identification of recovery measures•Spatial detection models to determine the contamination’s source and spreadThe functionalities of a leading Event Management System will be expanded by introducing beyond the state of the art online simulation capacities, allowing users to have a close to real-time view of the network’s behaviour.New sensors will be proposed for online biological and radioactive water quality measurements. SAFEWATER will improve sensor selection by carrying out benchmarking activities and develop an innovative detection approach based on “virtual sensors”, i.e. large networks of domestic sensorsThe project will test and validate the full SAFEWATER solution in three different scenarios, each situated in a diffe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on '2D Materials/Polyoxometalate Hybrids for Heritage Conservation'.

assistant: **Concept**

Protecting cultural heritage objects from biodeterioration and biodegradation is a major challenge faced by European society due to the implications in identity, economy and history. The aim of the HeriCare project is to create & expand a library of transparent hybrid materials composed of polyoxometalates & two-dimensional (2D) materials to be used in heritage conservation. This is the first time that such hybrids will be explored for this type of application and this project is expected to generate a broad impact on the fields of materials science and conservation. Moreover, selected hybrids will be incorporated to modern paper to provide ultra-resistant properties against biological contaminants for future heritage.  The implementation of this multidisciplinary and multi-sectoral project is expected to boost the personal career of the candidate by completing his knowledge about chemistry synthesis and acquiring a whole new set of research skills related to microbiology, biochemistry and cultural heritage. Furthermore, a multidisciplinary network will be created via long research visits to the conservation department of the library of the Spanish Royal Botanic Gardens and a short visit to a Restoration School (Huesca, Spain), which are expected to provide a concise insight into conservation work and the state-of-the-art of cultural heritage preservation techniques and products. In return, the candidate will transfer his expertise on 2D materials to the hosting and the research visit groups, which is expected to open new research lines and future collaborations in the field of novel antimicrobial materials. Finally, the project management and additional activities such as courses, coaching and dissemination will provide key skills for financial management, communicatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Neuro-electronic systems towards tissue implantation by neural grafting' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The final goal of the project is to characterize and optimize the in vitro interactions of a small networks of neurons, coupled to an array of embedded stimulating / recording planar microelectrodes, with other neuron populations, spatially separated from the network, simulating a host neural tissue to be interfaced to the network. In other words: the goal is to simulate in vitro the fate of a hybrid neuro - electronic system grafted into an injured nervous system, to stimulate its recovery. The in vitro characterization and optimization studies will be carried out inside a newly designed micromachined multicompartment chamber (NESTING chamber) which will be fabricated by means of advanced glass and silicon technologies. This chamber will allow a coordinated extensive analysis at the cellular and molecular level of chemical, mechanical and electrophysiological factors influencing neuronal growth, guidance and synaptogenesis under controlled in vitro conditions. Efforts will be specifically directed to build up in vitro neurobiological models sophisticated enough to reproduce some key features of the in vivo environment. Such models should offer a new advanced tool for in vitro experimentation to the Biomedical Community, thus reducing the need for animal experiments. By the end of the project, it is expected that detailed indications for the design of a miniaturized version of the neuro-electronic system will be obtained, suitable for subsequent in vivo grafting.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Intelligent supply chain management for the extended maritime enterprise' under Fifth Framework.

assistant: **Concept**

The proposed work suggests the development of a software framework capable of materialising an efficient and responsive extended enterprise, joining all trading partners, including customers, suppliers, factories and warehouses. The ultimate objective of the framework is to offer the potential for strategic alliances in a pan-European level in order to retain or increase the market share of European maritime and related enterprises. The proposed research aspires to provide the means, which will 'spark' the development of a high tech manufacturing and supply chain mechanism fully incorporated in the European maritime and transportation infrastructure. The proposed architecture will be based on the operation of a set of intelligent Internet enabled agents, providing highly innovative near real time decision support functions for a set of critical maritime business processes, which have not yet been addressed by software industry yet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Passage from intestine to brain: assessing the role of dendritic cells in capturing, expanding and disseminating prions' (IMMUNOTSE) targeting Fifth Framework.

assistant: **Abstract**

The aim of the proposal is to identify potential therapeutic targets at the pre-clinical stages of transmissible spongiform encephalopathies (TSE). Studies will demonstrate and characterize the roles of dendrite cells (Daces) in the propagation at TSE agents (prisons) to the nervous system. Daces are involved at multiple levels of the infectious process, and their properties and functions might be manipulated. The following steps will be analysed:- Penetration through the gut epithelium- Accumulation in the associated-associated lymphoid tissue - Spreading to other lymphoid organs- Factors of prison propagation (complement, receptors and receptors)- Spreading from lymphoid structures to the nervous system The in vivo research may not be performed on naturally infected subjects, and must use a relevant experimental model, i.e. a standard oral inoculation protocol with well-defined mouse experimental scrape strains. Finally, certain studies will require in vitro analyses, especially those aimed at identifying molecular interactions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Observation Platform for Technological and Institutional Consolidation of research in Safety' (OPTICS), addressing dissemination and exploitation.

assistant: **Impact**

The proposed coordination action OPTICS will provide oversight of progress in research and innovation aiming to improve the safety and security of aviation in accordance with Flightpath 2050 challenges and goals, exploiting as far as possible the identified metrics, achievements, main topic areas and broad industry knowledge and expertise base established in the development industry's SRIA.OPTICS will implement sustainable processes supporting stakeholders with strategic recommendations and a comprehensive vision of the safety-oriented research landscape. The action will implement a reference base and methodologies to perform assessment of progress both from a technological perspective - are we doing the right research, and from the societal and economic perspective - are we doing the research right - is it delivering societal and market benefit?The surveys are to be performed on an annual basis, in close collaboration with expertise drawn from the industry through a series of workshops, fully exploiting the network developed by ACARE. Assessments will be performed upon all on-going initiatives explicitly addressing safety research.The assessments will result in the provision of an annual report, identifying main performers, gaps and obstacles in the research landscape, formulating strategic recommendations, corrective actions and suggested priorities. The findings are to be presented and discussed with the aviation community at an annual Safety conference, organised on the premises of EASA, EUROCONTROL, etc.The results of the annual state-of-the-art review, together with relevant basic data, project information will be made available on the OPTICS repository accessible on the a action’s dedicated website.Finally, this action will ensure co-ordination and wherever possi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Model Design and Manufacturing of the Turbofan Configuration for Low Speed Aerodynamic and Acoustic Testing' in the context of a Seventh Framework call.

assistant: **Objectives**

A requirement has been produced to design and manufacture an innovative new wind tunnel model to enable the acquisition of aerodynamic and acoustic data. Nacelles and pylons will be included to accommodate two turbofan simulators which are to be supplied by DNW/ONERA.  A set of wings will be produced which will have removable leading edges and trailing edge flaps. This will allow a wide range of configurations to be investigated, including clean, take-off, landing and airbrakes on/off.  A modular empennage will also be produced. These items will be designed to interface with the remainder of the model which will be provided by a partner independent of this CFP.  The resultant model will be tested in a low speed wind tunnel at atmospheric pressure to investigate two topics. Firstly, the effectiveness of the empennage in shielding engine noise, and secondly the assessment of wing aerodynamic efficiency together with low speed take-off and landing performance and handling qualities. A large number of steady and unsteady probes will be installed in the model. Kulites ® will be mounted in the thin nacelle and empennage.  These will be supplemented by gauges on the empennage to measure loads.Aircraft Research Association (ARA) proposes to apply its extensive experience in wind tunnel model design and manufacture.  ARA will lead the programme of work with manufacturing support provided by Future Advanced Manufacturing Ltd (FAM).  ARA and FAM have worked closely on many wind tunnel model programmes, producing high quality models to exacting tolerances and demanding timescales. Over many years, ARA and FAM have established reliable working practices, innovative technical solutions to challenging requirements and effective project control and management processes. ARA and FAM wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Metal homeostasis in nodulated Medicago truncatula' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Legumes are the second major food source for humans and livestock, and crucial elements in any sustainable strategy of agriculture, since they are the main responsible of fixed nitrogen in natural ecosystems, and the largest supplier of nitrogen for agriculture. This is due to the establishment in their roots of a symbiotic relationship with rhizobia. In it, the rhizobia colonize a new organ, the nodule. In this organ, a microaerobiotic environment is essential for nitrogenase, the key enzyme of nitrogen fixation, to work. In exchange for fixed nitrogen, the plant provides the rhizobia with fixed carbon and oligonutrients such as iron and copper. Iron and copper play an essential role in the nodule, being involved in nitrogenase enzymatic activity, creation of the microaerobiotic environment, protection against free radical species created as side product of nitrogen fixation, energy obtention, and in producing regulatory free radicals, among other processes. However, essential heavy metals are scarce nutrients in soils, and are a frequent limiting crop yields. Therefore, we hypothesize that the host legume must strive to satisfy the nodule’s demand for more metals, and consequently mobilize these precious nutrients from other parts of the plant. As a consequence, the legume must alter the expression levels of metal homeostasis genes, change the distribution of metal along the plant, express new metal transporters in the nodule, and recover the metals once the nodule senesced. We will test this hypothesis by studying the : i) metal transcriptome in the nodulated plant, ii) metallome in the nodulated plant, iii) functional characterization (biochemical and physiological) of Cu and Fe transporters expressed in the nodule. For this, we will use as a model plant Medicago tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A Holistic Digital Mine 4.0 Ecosystem' (2021-2027).

assistant: **Concept**

In the context of industrialization, informatization and sustainable development of the mining sector, Mine.io solution will build a novel mining digital ecosystem and a systemic structure for the implementation of Industry 4.0 in mining industrial environments. Mine.io solution will embrace the whole mining value chain from resources’ exploration, extraction, and processing to waste management and post mining activity. Our fundamental concept is the provision of a manufacturing system architecture, under cloud environment, to be applied in the digital twin mining “shop floor”. Mine.io envisions an innovative cloud services system and a novel mining ecosystem of sharing, interconnection, and open cooperation. Mine.io will establish a unified data infrastructure and collaborative platform ecosystem to promote the openness and sharing of data and improve the cooperation environment between mining enterprises. Mine.io aims the enhanced systematization of the basic processes of the mining industry, that involve asset and process equipment optimization, through embedded predictive analytics, and optimization procedures based on completely data-driven processes and the integrated cyber-virtual and cyber-physical systems, automation and robotization of mining exploration and production processes, sustainable mining, and post mining management. To meet the increasing social and environmental concerns, Mine.io will enable a resource optimization and digital transformation framework, embedding specific circular economy and “low-impact mining” strategies. Energy innovations, including the transition to autonomous electric vehicles, will lead to socially conscious profit, while creating a safer and cleaner environment for front-line workers, including higher air quality for those w