RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Green deal inspired correlative imaging-based characterization for safety profiling of 2D materials' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

ACCORDs will develop an imaging-based characterization framework (ACCORDs framework) for the holistic correlative assessment of Graphene Family Materials (GFMs) as a representative of 2D nanomaterials (NMs) to assess and predict 2D NMs health and environmental risks. The ACCORDs framework will operationalise safe and sustainable by design (SSbD) strategies proposed in past or ongoing H2020 projects or within OECD by correlating low-, medium-, and high-resolution physico-chemical-biological imaging-based methods with non-imaging methods in a tiered approach. ACCORDs will deliver the ACCORDs framework and user guidance, new imaging-based characterisation methods (3-6 methods), reference in vitro tests (up to three new tests), new reference 2D NMs (up to three) for different matrices, a new minimum information reporting guideline for FAIR data sharing and reuse of images as well as an atlas with reference images for diagnostics of compromised safety of GFMs / GFM products. The new guidelines and standard proposals will be submitted to standardisation bodies to allow creation of regulatory ready products. The novelty of ACCORDs is in translating the principles of medical imaging-based diagnostics to 2D material hazard diagnostics. ACCORDs will accelerate industrial sectors in the area of aviation, marine construction, drone production, flexible electronics, photovoltaics, photocatalytics and print inks-based sensors. The value ACCORDs proposes to the graphene industry are practical, easy, imaging-based tools for GFM quality monitoring next to the production line with a possibility to be correlated with advanced high-resolution imaging characterization methods in case hazard i.e. deviation from controls (benchmark values) are diagnosed. The ACCORDs framework and tools will c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Scalable Policy-awarE linked data arChitecture for prIvacy, trAnsparency and compLiance' under Horizon 2020.

assistant: **Concept**

The SPECIAL project will address the contradiction between Big Data innovation and privacy-aware data protection by proposing a technical solution that makes both of these goals realistic. We will develop technology that: (i) supports the acquisition of user consent at collection time and the recording of both data and metadata (consent, policies, event data, context) according to legislative and user-specified policies; (ii) caters for privacy-aware, secure workflows that include usage/access control, transparency and compliance verification; (iii) demonstrates robustness in terms of performance, scalability and security all of which are necessary to support privacy preserving innovation in Big Data environments; and (iv) provides a dashboard with feedback and control features that make privacy in Big Data comprehensible and manageable for data subjects, controllers, and processors. SPECIAL shall allow citizens and organisations to share more data, while guaranteeing data protection compliance, thus enabling both trust and the creation of valuable new insights from shared data. Our vision will be realised and validated via real world use cases that - in order to be viable - need to overcome current challenges concerning the processing and sharing of data in a privacy preserving manner. In order to realise this vision, we will combine and significantly extend big data architectures to handle Linked Data, harness them with sticky policies as well as scalable queryable encryption, and develop advanced user interaction and control features: SPECIAL will build on top of the Big Data Europe and PrimeLife Projects, exploit their results, and further advance the state of the art of privacy enhancing technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hybrid Lithium Metal-based Scalable Solid State Battery Manufacturing' (HyList), addressing dissemination and exploitation.

assistant: **Impact**

The HyLiST project aims at developing Generation 4b all-solid-state lithium-ion batteries (SSBs) for road and aeronautic applications. These will be based on a high voltage (HV) spinel structured LNMO cathode, and hybrid single-ion polymer electrolyte (HSICP) and laser pulse deposited lithium foil on current collector as anode. Overall, processing is aimed at being scalable and easy to transfer to currently available manufacturing infrastructure in Europe. Wet coating for composite cathode preparation and dry processing for the hybrid solid electrolyte increase production efficiency and shorten developing periods. Solvents’ environmental impact is minimized, e.g. by elimination of fluorinated binders. A cobalt-free, high voltage (ca. 4.7V) LNMO cathode de-risks on the dependence of cobalt, and a single-ion polymer electrolyte helps to develop high Li ionic conductivity (≥0.5 mS/cm at room temperature) with a high transfer number (~1.0).  Roll-to-roll PLD manufacture of thin and ultra-thin Li anodes will  strengthen the European supply chain for semi-finished anode components. A granulation process prepares uniform hybrid solid electrolyte feedstocks to guarantee microscopic uniformity and thereby the resulting electrochemical performance. Environmental impact will be monitored and materials and processes multicriteria optimization performed. Digital twinning is built simultaneously for the simulation of cell production, with further iteration aiming at improved energy density and reduced cost. HyList identifies the essential steps for making all-solid-state batteries at a large scale. It provides valuable insights into efficient manufacturing methods and helps various industry players, like machine engineers, cell producers, and equipment manufacturers,  to move toward
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'AI-powered Adaptive radiation dosimetry: An innovative solution for safer and precise MRI guided RadioTherapy'.

assistant: **Concept**

Current radiotherapy is fully reliant on semi-automatic treatment planning systems (TPS) that depend on highly toxic CT scans and human clinical expertise for creating a treatment plan. As a result, the procedure is inefficient and inefficacious resulting in poor treatment outcome and severe side effects. In recent years, there has been an emergence of the concept of MRI-guided radiotherapy, wherein non-toxic and high resolution MRI images are used to guide treatment planning. As a result, several key players in the radiotherapy market such as Elekta and ViewRay have introduced MRI embedded linear acclerators to perform MRI imaging during radiotherapy administration. However, as of yet no TPS exists on the market that enables fully automated MRI-guided radiotherapy, in order to provide real-time dose adjustment.To meet this market gap, TheraPanacea, a young start-up working on cutting edge AI technology, aims to introduce the world's first fully automated TPS for MRI guided radiotherapy - the ART-AI platform. This platform is built using state-of-the-art technology in reinforcement learning and employs proprietary Monte Carlo algorithms to perform anatomical simulation using MRI images to rapidly update the treatment plan on-the-fly. Moreover, the platform employs latest advances in positioning algorithms via a deformable registration framework to ensure automatic and precise patient position adjustment inside the linear accelerator. Thus, the ART-AI platform has the potential to revolutionize radiotherapy and enable it to achieve its full potential. In this SME-2 project, we will finalize the development steps of the platform, incoporate all the software modules into one suite and perform clinical validation in collaboration with our clinical partners. The end-result o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'PRIvacy and Security MAintaining services in the CLOUD' (PRISMACLOUD).

assistant: **Concept**

With a current volume of over USD 100 billion and annual growth rates of over 10%, the world-wide market for cloud computing can be considered as the major growth area in ICT. However, big companies and public authorities are reluctant to entrust their most sensitive data to external parties for storage and processing. The reason for their hesitation is clear: There exist no satisfactory approaches to adequately protect the data during its lifetime in the cloud. PRISMACLOUD addresses these challenges and yields a portfolio of novel security enabled cloud services, guaranteeing the required security for sensitive data in the cloud.Techniques for outsourcing computation with verifiable correctness and authenticity-preservation allow to securely delegate computations to cloud providers. A distributed multi-cloud data storage architecture shares data among several cloud providers and improves security and availability. Dynamically updating shares by means of novel techniques avoids vendor lock-in, preserves data authenticity, facilitates long term privacy and promotes a dynamic cloud provider market. Claims about the secure connection and configuration of the virtualized cloud infrastructures and properties of cloud topologies are verifiable by means of cryptographic techniques. User privacy issues are addressed by data minimization and anonymization technologies due to the application of privacy-preserving cryptographic techniques. As feasibility proof, three use cases from the fields of SmartCity, e-Government, and e-Health, will be implemented and evaluated by the project participants.The PRISMACLOUD work program is complemented with activities addressing secure user interfaces, secure service composition, secure implementation in software and hardware, security certific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'New industrial value chain for Safe, sECure and Resilient cIties and Territories'.

assistant: **Innovation**

The security sector is considerably evolving, by adapting the offer to the risk and threats and by permanently aggregating emerging innovations. The digital is disrupting this industry, by adding new capacities and new threats. The security sector is very fragmented. SecurIT aims to create a new global competitive security industrial (product & service) value chain by supporting a better integration of innovative security systems, with a cross-sectoral and European approach, to support the time to market optimization, the integration of privacy and security by design at all steps of maturity, with a cross-border collaboration between SMEs and other RDI actors. This vision is supported by a 4 step-approach:#1: : Analysis of the demand-side, mobilizing 40 integrators/end-users to identify their needs and 42 potential demonstrators including major actors as large industry, cities, critical infrastructures operators that will join SecurIT as user group, experiment hosting or supportive partners (26 support letters in annex - AIRBUS, THALES, ATOS, COESS, ECSO, cities, EEN etc.).#2&3: Involving supply sides (SMEs), aiming to get 300 EoI to participate in SecurIT and attracting +1000 SMEs to get part through outreach actions (15 letters of SMEs in annex).#4: Select and Support 63 innovation projects involving 126 SMEs with over 3,5M€ of FSTP through 2 Instruments of support from TRL5 to TRL9 (Prototyping and Demonstration/Pilot), and +700K€ in services provided by partners. Highquality experts will be involved in the SMEs selection process.The consortium is as a whole, with 7 Security and complementary Clusters from France, Belgium, Lithuania, TheNetherlands and Denmark, coming from most relevant security / cybersecurity Regional Innovation Hubs in Europe, and the SecurIT part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding the Proximate Mechanisms ofCanine Cooperation' (CanCoop) under Seventh Framework.

assistant: **Objectives**

Although it is clear that human collaborative skills are exceptional, elucidating similarities and differences of proximate processes underlying cooperative interactions between non-primate and primate taxa may have important implications for our understanding of cooperation in humans and non human-animals via a profound knowledge of 1) socio-cognitive skills as adaptations to specific environments and/or 2) the evolutionary background and origin of our own skills. The closely related wolves and dogs constitute the ideal non-primate model to implement this approach, since cooperation is at the core of their social organization and they are adapted to very different environments.I propose a series of experiments with wolves (N = 20) and identically raised and kept dogs (N= 20) that will focus on cognitive processes closely linked to the emotional system such as empathy, inequity aversion and delayed gratification that are thought to be involved in triggering and maintaining primate cooperation. In Part 1 of the project, we will investigate whether and to what extent these processes are present in canines, while in Part 2 we will elucidate how they influence partner choice in cooperative interactions. Using social network theory, we will integrate knowledge about animals’ emotional tendencies and cognitive abilities to model canine cooperation. This is an important step towards unifying theoretical and empirical approaches in animal behaviour.CanCoop incorporates innovative methods and a novel approach that has the potential to elucidate the interactions between proximate and ultimate processes in regard to cooperation. The nature of CanCoop guarantees public and media attention needed for proper societal dissemination of the results, which will be relevant for animal beh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The first effective remedy for acute pancreatitis disease' under Horizon 2020.

assistant: **Concept**

ChemICare is a high-tech spin-off of the University of Piemonte Orientale and has patented and preclinically developed small molecules that are unique in their capacity to modulate calcium ions uptake in cellular processes. Calcium overload associated with Store-Operated Calcium Entry hyper-activation has been proved to be to be the key trigger in a cluster of diseases, including Acute Pancreatitis, which affects over 10 million people globally and is the most common gastroenterology discharge diagnosis in Europe and the US. AP is associated with significant disease burden, emergency room visits, frequent hospitalizations, and patients often undergo endoscopic and surgical procedures and are admitted to intensive care, costing more than 20 B€ yearly to National Healthcare Services. Preclinical data obtained so far demonstrate that drug candidate 39 represents a breakthrough innovation in the field of pharmacological therapies for AP. We are now in the process of generating the last data to complete the preclinical regulatory dossier, which will pave the way for the Phase I and II clinical trials which will lead to an out-license agreement to a large pharma company prior to the initiation of Phase III. The revenues will therefore be reinvested to finance development of the same technology for other therapeutic indications associated with calcium overload (e.g. Duchenne Muscular Dystrophy and Tubular Aggregate Myopathy). This Phase 1 is of utmost importance to validate the market position of ChemICare molecules, apply for orphan designation, and plan the preclinical study necessary to prepare the clinical validation Phases in the frame of the Phase 2. Our goal is to have a solution ready for the market by 2024, which will be cost-effective for health providers and deliver
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of a novel function of lysosomes in mitosis for cancer therapy' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Controlling cell cycle, process by which cells progress and divide, is at the heart of cancer research therapies. Tumor cells signature often lays in high proliferation rate, alterations of multiple intracellular signaling networks and hijacking of programmed-cell death pathways. Implication of autophagy and lysosomal biology in cancer is still controversial. Lysosomes are catabolic vesicles involved in the degradation of biological material and need to be tightly regulated. Lysosomes may influence cancer formation and progression by regulating many complex processes of cell biology, such as cell signaling, cell death, nutrient sensing and cell metabolism. Lysosome function depends on lysosome acidification capacity modulated by proton pump v-ATPase activity and on its intracellular localization driven by motor proteins, mainly by motor protein kinesin KIF5B. We recently discover an innovative mechanism involving lysosomes impairment to induce mitotic error that could potentially lead tumor cells to cell death.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Towards Holographic QCD and beyond' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The main goal of the proposal is to construct a holographic QCD model. Our preliminary results strongly suggest that D7-branes embedded in a 10d supergravity background based on the deformed conifold is the proper setup to study various QCD phenomena like chiral symmetry breaking, confinement etc. We also intent to find new deformed cones and the corresponding 10d backgrounds. Our second aim is to use these deformed cones for the warped D-brane inflation scenario. In particular, we would like to know whether the new models allow for slow roll inflation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Unravelling the cell-cell circuits underlying the functional reprogramming of KCs and TAMs during liver metastasis' (MetaMacNiche) under Horizon Europe.

assistant: **Objectives**

The liver is one the most common metastatic sites for several cancers. Unfortunately, liver metastasis patients show a particularly low response to immunotherapy. One of the main immune cells populating liver metastases are macrophages. These cells have been shown to play a key role in the regulation of anti-tumor immune responses, including response to immunotherapy. However, we still lack the capacity to modulate macrophage activity during liver metastasis, because we do not yet understand their functional diversity and do not know the molecular signals that drive the pro-tumoral activity of macrophages during liver metastasis. The host lab has recently reported a major role for cell-cell interactions within the microenvironmental niche in the development and functional specialization of liver macrophages. My preliminary data indicate that liver metastasis is accompanied with the expansion of both liver-resident Kupffer cells (KCs) and monocyte-derived tumor-associated macrophages (TAMs). Single-cell analysis in mouse and human revealed that TAMs recruited during metastasis are heterogeneous and transcriptomically different from KCs, suggesting a distinct functional specialization. The molecular pathways involved in the functional reprogramming of KCs and TAMs and their relative contribution to tumor growth, remain poorly understood. In this MetaMacNiche project, I will use a combination of cutting-edge spatial multiomic technologies, intravital microscopy, and an in vivo CRISPR screen to investigate the role of KCs and TAMs in liver metastasis. Through a combination of in silico predictions and high-throughput in vivo validations, I will identify the key cell-cell interactions involved in the functional reprogramming of KCs and TAMs during liver metastasis. Finally,