RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Research Center on Interactive Media, Smart System and Emerging Technologies' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Innovation activities targeting the Smart Specialisation Strategy of Cyprus-S3Cy require a solid scientific and research basis. Despite having the highest ratio of tertiary education among adults in Europe and well performing academic institutions research is currently confined in academia. To reverse this detrimental relation between research and innovation, Cyprus is in dire need of a catalyst to help the country RISE out of its RTDI slumber. This proposal seeks the European Commission’s support to establish, for the first time in Cyprus, a Centre of Excellence that fosters world-class research activities and serves as a paradigm for bridging scientific research with innovation.RISE (Research centre on Interactive media, Smart systems and Emerging technologies), seeks to play a key role in the country’s RTDI reform, by bringing together an unparalleled team. The initiative is led by Nicosia Municipality, collaborating with all state universities of Cyprus (UCY, CUT, Open University of Cyprus), and is backed by the expertise and long-term commitment of two world-leading science and innovation institutions (UCL, MPG). With a spacious building already committed by Nicosia Municipality to host RISE at the centre of Nicosia, RISE will kick-start the Municipality’s set out strategy to foster the development of an inclusive innovation and creativity ecosystem at Nicosia’s Quarter of Creative Industries (QCI). QCI will host infrastructures and entrepreneurship initiatives in close spatial proximity to each other, within the historic city centre, helping focus and integrate existing fragmented activities creating a cluster of research and innovation. RISE will spearhead acting as a catalyst. RISE has already secured 35.5m in financial commitments in addition to the TEAMING gra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mycelium Material Bonding: Molecular Mechanism and Enhancement Strategy'.

assistant: **Objectives**

The development of natural-based materials is crucial to reduce environmental impact and achieve a circular economy. Fungal mycelium has recently achieved significant attention as a new biobased sustainable material. In nature, filamentous fungi colonize lignocellulosic (i.e. plant) substrates such as wood and agriculture waste streams; their elongated mycelium works as a natural glue that binds the substrate together. Taking advantage of this unique binding property, people have developed innovative methods to grow fungal mycelium in different lignocellulosic waste streams resulting in composite products with various forms, densities, and target applications. However, little is known about the fundamentals, especially the essential factors that determine the material properties. This project aims to provide an in-depth understanding of the adhesion of mycelium to the substrate and to use this knowledge to enhance this adhesion to optimize fungal mycelium materials thereby contributing to the EU’s sustainable plan. The project will focus on three different levels: understand filamentous fungi adhesion to lignocellulosic surfaces at the molecular level; improve this adhesion based on the findings; apply this technology to novel fungal mycelium-lignocellulosic-based sustainable materials development. This project will carry out a multidisciplinary study linking molecular and chemical biology to materials science and technology.  The transfer of knowledge will benefit both the researcher and the host and further promote mycelium material development. The result of this proposal will be shared with researchers in different disciplines, industrial partners, and the public. It will contribute to EU’s sustainable technology.


**Keywords:** mycelium adhesion lignocellulosic bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analogues Of Thromboxane For The Treatment Of Cardiovascular Disease' in the context of a Seventh Framework call.

assistant: **Objectives**

Cardiovascular disease is the leading cause of death in the developed world; in Europe it led to over 4 million deaths (47%) last year. Platelets play an essential role in haemostasis and a critical role in thrombosis and cardiovascular disease. Their activation by thromboxane is crucial for thrombus formation but this can lead to myocardial infarction or stroke. Due to the important role of platelets in cardiovascular disease, patients at risk of thrombotic events are routinely prescribed anti-platelet drugs that interfere with the amplification of platelet function (e.g. aspirin). The mechanism of action of aspirin is to block the biosynthesis of thromboxane, a fatty acid that activates platelet formation and aggregation. However, it has side effects. Alternative COX inhibitors that block production of related fatty acids have been developed, but have had to be withdrawn from the market due to side effects.An alternative strategy that does not interfere with the biosynthesis of thromboxanes is described. During the biosynthesis of thromboxanes other fatty acids e.g. prostaglandins are also produced and their elimination causes side effects. Instead, we plan to allow the body to make thromboxane, but to develop an antibody to remove it from the system, so that it does not have a chance to cause harmful effects. However, antibodies cannot be generated of thromboxane itself as it is too unstable (half life 35 s). Hence, an analogue that mimics thromboxane in having a highly strained acetal motif will be synthesized, stabilized by incorporating fluorine substituents at strategic positions. Initially the methodology will be developed by completing a short synthesis of the hydrolysed form of thromboxane and then go on to make the fluorinated version. A commercial enterprise
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Examining effects of daytime naps on memory consolidation and emotional reactivity in a well-powered, pre-registered multi-lab collaboration', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

This proposal will examine if a daytime nap improves memory consolidation, with the largest and most diverse sample size of any study ever conducted on this topic. We will achieve this through a preregistered multi-lab collaboration with contributing sleep labs from all over the world. Previous research has indicated that sleep is beneficial for memory consolidation; it has further been suggested that sleep mainly consolidates emotional memories, and that sleep helps to reduce the emotional reactivity associated with emotional experiences. Recent meta-analytic work has, however, revealed that previous studies on this topic have been massively underpowered and that selective publishing of positive findings is a major problem in the field.The study will have a within-subject crossover design. Participants will come to the lab in the early afternoon and encode neutral and negative images. For each image, they will also rate the emotional response it elicits. Participants will then either take a nap, monitored with polysomnography, or spend an equivalent amount of time awake, and then have their memory performance for the images tested, and rate their emotional response to the images once again. This research design will allow us to answer the following questions: A) will sleep, as compared to wake, increase memory consolidation? B) Will this sleep dependent-consolidation benefit be more pronounced for negative compared to neutral items? C) Will any particular sleep stage be especially involved in memory consolidation? D) Will sleep, as compared to wake, decrease the emotional reaction to previously viewed images? By doing this as a registered report, we will increase transparency and reduce risk of selective reporting of significant results. This study will, for the first
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'evolutionary platform to predict breast cancer (BC) patients outcome and response to therapy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

“BARRICADE” is about an evolutionary platform to predict breast cancer (BC) patients outcome and response to therapy in a faster and specific manner. Breast cancer is one of the leading causes of cancer mortality among women and is characterized by a high interindividual variability in response to cancer treatment, and often resistance to therapy arise over the time or after first line of treatment. For this reason, the therapeutic approach of each patient has to be set up during its management causing some gaps, useless toxicities and a losing of time useful for patient’s cure. In cancer research, cells are usually grown in a monolayer on dishes of polystyrene plastic to perform experiment or toxicity studies. Alternatively, researchers use animal models that are able to mimic a more physiological growth of tumor cells and they take in account also the microenvironmental influences. Unfortunately, animal models do not recapitulate the human complexity, and sometimes they do not predict tumor behaviour and clinical response. For this reason, organoids are emerging as new more complex system that may overcome the limitations of traditional cancer model. “BARRICADE” will contribute to taking BC cancer therapy to beyond state-of-art, developing personalized anticancer therapies and giving useful information for cure setting up. Indeed, progress in developing in vitro 3D organoid culture system using primary human breast cancer tissues have attracted great interest as an emerging tools for precision medicine. BARRICADE will help to overcome some of those barriers by giving preclinical information for future therapy settings.


**Keywords:** breast cancer, personalized anticancer therapies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Intestinal flora : beneficial and detrimental effects on host nutritional balance and health' to be submitted under Fourth Framework.

assistant: **Abstract**

Objectives and deliverables: The overall objective of the proposed project is the Co-ordination of European research and determination of research orientation especially regarding areas of gut microbial ecology in which there is lack of knowledge but which nevertheless are of crucial importance for human health and well-being. This wi be accomplished by bringing together a unique combination of experts from unive groups, research institutes, and industries from all over Europe interested in the common theme of gut microbial ecosystem. This will increase co-operation, communication and research in this multidisciplinary field. In addition to co-ordinating existing efforts, the programme will seek to define topics where further research and development is essential ta ensure the development of benefits to end-users. This action will strengthen the links between already existing FAIR contract participants that share overlapping domains of interest. Most importantly, in addition to academia and public research sectors. The Action will include industrial partners who are knowledgeable as to what industrial applications could come about from fundamental research. The latter partners will facilitate the dissemination of the results to other potential industrial end-users.  The final deliverable will be to arrive to a consensus as to the current state of the art concerning gut microbial ecology and intestinal flora and what progress needs to be made in each domain to fulfil the scientific goals fixed.  Relevance: The concerted action proposed here will comply with the Agriculture and Fisheries workprogramme included in Area 3 (Generic Science and Advances Technologies for Nutritious Foods), Sub-area 3.1.4 (Physico-chemical Aspects of Food Absorption and Metabolism).  Organisati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'International colloquium on gender, population and development in africa""' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The project will support the organization of an international colloquium entitled Gender, Population and Development in Africa". It will be held in Abidjan in February 2001. Its objective is to gather the results of research conducted in the field, in Sub-Saharan countries and in North Africa, on gender systems and their interrelations with population and development issues, and to put these results at the disposal of decision-makers, of field operators and of training staff. This colloquium organized in collaboration with European and African institutions, will promote the circulation of knowledge between English and French-speaking researchers, between Africans scholars and Africans from other continents. More than one hundred researchers and field workers have proposed contributions. Nine sessions will successively deal with: notional and methodological developments, efforts made in the area of rights, gender inequalities in the areas of production, migration, health, and education, gender relations in the couple, reproduction and family structures."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The Fluctuating Enzyme: From Catalysis to Vibrational Dynamics' (FLUCTENZ) under Horizon 2020.

assistant: **Objectives**

Enzymes spin the wheel of life by catalyzing a myriad of chemical reactions central to the growth, development, and metabolism of all living organisms. Without enzymes, essential processes would progress so slowly that life would virtually grind to a halt, and the quest to determine their inner workings thus continues to attract and fascinate scientists over a broad range of disciplines. Cutting-edge methods now allow one to observe and manipulate individual enzymes in their reaction course. These revealed that chemistry at the single-molecule level is inherently stochastic and, at times, extremely unintuitive. Thermal fluctuations push enzymes to vibrate erratically and force a probabilistic description, but classical approaches are deeply entrenched in determinism, and so is our basic expectation for how things should behave in the world around us. The groundbreaking purpose of this proposal is to bring advanced theoretical methods and mathematical tools to the analysis of stochastic fluctuations of enzymes and proteins at the single-molecule level. These will be based on state-of-the-art approaches in statistical physics and stochastic processes that I will adapt and further advance to need. Equipped with mathematical techniques that have so far been foreign to the field, I expect to rectify fundamental flaws in our understanding, predict the emergence of novel phenomena, and show how single-molecule fluctuations can be extracted from bulk, steady-state, concentrationsdespite belief that this is fundamentally impossible. Novel analysis methods that I will apply to tens of thousands of protein structures would complement these efforts and aid in the discovery of unifying principles governing thermal fluctuations of enzymes and proteins. The amalgamation of all these e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Critiquing Assessements of Decision-Making Capacity' under Horizon Europe.

assistant: **Concept**

The focus of this project is what it is for an agent to be able to make a decision, and when we should count them as being able to do so. This is a question that has received sustained attention throughout the history of philosophy, and there are many different theories and models of decision-making on offer. Different views of decision-making can have huge practical impact: in various legal and medical contexts, decision-making capacity is assessed in order to determine how people are viewed and treated, including whether they are fit to stand trial, have the right to refuse medical treatment, or are viewed as criminally responsible.Drawing on a range of philosophical, psychological, cognitive scientific, and psychiatric literature, this project will aim to evaluate different philosophical theories of decision-making. The novel contribution of this project, and its particular methodological focus, will be to focus on assessing theories of decision-making by their practical impact - an important, but often-neglected metric for assessing philosophical theories and concepts.As well as further elucidating and clarifying the core question of the nature of decision-making, two key benefits of this project are envisaged. First, a substantive contribution to the question of how decision-making ought to be assessed in the relevant legal and medical contexts. For example, one key focus of the project will be the neglect of external influences (social and environmental) in facilitating decision-making, where currently in many contexts they are treated solely as potential hinderances. Secondly, the project will bring recent work in philosophy of science on 'pluralism' to bear on the question of how legal frameworks and decisions are and ought to be informed by relevant scientific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Information and Communication Technologies \nfor the Full Electric Vehicle' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The proposed coordination action addresses enabling technologies of full electric vehicles (FEV). The focus of the initiative is set on ICT which open new technology paths towards energy efficiency, functionality and usability and are complementary to future advances in performance of battery cell technology. To fight climate change, cut emissions and secure energy supply, transport based on FEVs will soon be strongly demanded by public and private stakeholders worldwide. It can be foreseen that early technology leadership will be determinant for the global competitiveness of major European industries such as the automotive, energy and ICT sector.ICT4FEV is aiming at building a R&D community, creating a European roadmap and recommending standards, regulations, business cases and R&D priorities for the FEV. In its core consortium it will therefore bring together for the first time major industrial partners to start a dialogue on a common understanding about impact, R&D priorities, infrastructure needs and requirements. Opportunities of technology transfer, e.g. between electric road vehicles and aircrafts, shall be taken into account and foresighted recommendations shall be made.To broaden the view of its work, ICT4FEV will involve more than 15 key stakeholders representing both academia and the involved industry sectors from across Europe. Particularly involved will be vehicle manufacturers and suppliers, companies from the energy sector focussing on the vehicle-to-grid interface (V2G) and companies from the electronics and semiconductor sector dealing with components and systems. Furthermore, representatives of European and international public authorities shall take part in the dialogue.The outcome of ICT4FEV will serve as guideline for setting strategic priorities on