RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AGroFOod clusters platform with common long-term Research and Innovation Strategy towards Economic growth and prosperity' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The overall objective of AGFORISE Project is to create a common dialogue platform and a joint action plan among the Agrofood clusters that will maximise capacity for research and benefit from research infrastructure through complementariness and synergy, so as to contribute for sustainable development, prosperity, economic growth and global competitiveness of the regions. In this content the specific objectives are: Strengthening a sustainable dialogue between the participant Agrofood clusters, Creating an R&D&I Strategy Dialogue & Cooperation, Enhancing Trade & Investment opportunities in Agrofood sector, Maintaining sustainability of cross-collaboration between the participant regions, Stimulating utilization from national/EU R&D funds The activities within the scope of the AGFORISE project will focus on: Analysis of Agrofood sector in participant regions in order to maximise the benefit from the research opportunities for regional economic development, Development of a common dialogue platform between the participant regions for sharing information and experience that result in a Joint Action Plan (JAP), which will contribute to strengthen the regions’ capacity for investing in and conducting research and technological development activities that can enhance significantly to economic development, Improvement of cross collaboration among the research and commercial communities to result in commercially ended research. The main focus of the project will be on Agrofood area, which is the most important source of income in all participant regions. The implementation of the project will increase the competitiveness of European regions in Agrofood industry and bring significant added-value to the European Agrofood community. The consortium has been formed by 12 partners fr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Comparative systems-level studies of animal appendage morphogenesis' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Understanding the transition from molecular to cellular patterns and then to elaborate biological forms remains a major challenge in developmental biology. Recent advances in biological imaging enable to study the complex mechanisms that control tissue and organ morphogenesis. I will focus on animal appendages that develop particular shapes and sizes to suit the lifestyle of the organisms. Among animal models, the crustacean Parhyale hawaiensis offers a unique capacity for microscopic live imaging and tracking of all cells of developing appendages continuously from early specification up to late differentiation. Parhyale embryos undergo direct development from fertilized eggs into miniature adults, they are transparent and amenable to all sorts of embryological and functional genetic manipulations. Importantly, each Parhyale embryo develops a variety of specialized appendages along the anterior-posterior body axis that differ in size, shape and pattern. I will study how morphogenetic mechanisms are deployed differentially in these neighboring growing appendages to produce their morphological differences. Transgenic embryos expressing fluorescent tracers will be recorded with Selective Plane Illumination Microscopy in vivo throughout appendage development. Using these time-lapse recordings, I will first generate and compare the cell lineages of serially homologous appendages to identify patterns that account for their morphological differences. I will then quantify the cell behaviors that contribute to appendage growth and form, including rates and patterns of cell division and cell death and orientation of cell divisions. Finally, I will investigate at single-cell resolution how the Hox regulatory genes guide distinct cell behaviors to control appendage morphogenesis. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Capturing kinase-substrate pairs in intact mammalian cells by using unnatural amino acid mutagenesis and photocrosslinking' in the context of a Seventh Framework call.

assistant: **Objectives**

Aim of this project is to develop a method for capturing kinase-substrate pairs in living mammalian cells using unnatural amino acid mutagenesis and affinity crosslinking. Photocrosslinking amino acids (containing benzophenone or azide groups) will be introduced site-specifically into the backbone of target proteins using ad hoc developed orthogonal tRNA/synthetase pairs functional in mammalian cells. By introducing the photocrosslinker at suitable positions into the substrate binding region of a protein kinase, we expect to crosslink its natural substrates in response to cell stimulation and UV irradiation. Likewise, by introducing a photocrosslinker close to the phosphorylation site of a kinase substrate we will aim at capturing it upstream kinase. Once proofed the feasibility of the approach using the PKA/CREB system, we will apply such strategy to identify unknown kinases-substrate pairs involved in signaling pathways regulating fundamental cellular processes (BRCA1 and NF-kappaB pathway). This will represent a new general method for capturing transient protein-protein interactions in vivo by applying a minimal perturbation to the natural system, which will respond to a need of the scientific community, since methods for studying protein-protein interactions available nowadays mostly involve non-native conditions. The use of orthogonal tRNA/synthetase pairs for unnatural amino acid mutagenesis is a very recently developed technique, which is applied in very few laboratories in the world, and which has a tremendous potential for enabling the study of protein structure and function directly in the living cell. In the outgoing phase the fellow intends to learn this technique and explore new possibilities of its application. This knowledge will be applied in the return
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ICOS improved sensors, network and interoperability for GMES' (ICOS-INWIRE).

assistant: **Concept**

The fundamental objective of the ICOS-INWIRE project is to enhance the capabilities of the ICOS infrastructure and fill in critical gaps for monitoring fluxes and concentrations of greenhouse gases, in order to meet the needs of operational users in the GMES program. It will achieve this by: Developing and testing autonomous sensors systems for greenhouse gas fluxes and concentration, enhancing the data processing operational capabilities of the ICOS concentration and flux measurement network and developing inter-operability between ICOS and other in-situ GHG monitoring networks while assuring the convergence with space systems and the harmonization of exchange mechanisms. These activities will contribute to Europe’s capacity to set up pan-European and global networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding factors affecting durability of crop resistance genes' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

In response to threats to global food security from population increase and climate change, there is an urgent need to develop UK crops that suffer less losses from diseases and produce sustainable yields, despite withdrawal of fungicides (EU legislation) and the need to mitigate climate change from agriculture (UK government targets). Thus, there is a need to develop strategies for deployment of crop resistance that is easily identified by breeders (ideally mediated by specific resistance (R) genes) and not easily rendered ineffective by rapid changes in pathogen populations (durable) or changes in the environment (stable). There is evidence that combining R gene and background (quantitative) resistance may make the resistance more durable. Availability of data sets relating to factors affecting durability of R genes over successive cropping seasons and new genomic information about the crop host and pathogen makes Brassica napus (oilseed rape)/ Leptosphaeria maculans (phoma stem canker) an ideal model system with which to develop a scheme for deriving criteria for selection and deployment of crop resistance.The work proposed in this project will involve 3 tasks.Task 1. Factors influencing durability of R genes in winter oilseed rape cropping considering data on the effect of background quantitative resistance on durability of R gene resistance and data on fitness costs of virulenceTask 2. Understanding interactions between host and pathogen gene products in relation to durability/environmental stability of R genes using modeling and experimental approachesTask 3. Develop scheme to describe the factors affecting the durability of R genes and identify generic principles by understanding factors affecting the durability of R gene resistance, which can be applied to a wid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Advanced sensors and novel concepts for intelligent and reliable processing in bonded repairs' to be submitted under Sixth Framework.

assistant: **Abstract**

The main limitation of the existing technology in bonding repair of aerospace structures lies in the inability of the repair control systems to assess the actual material state and integrate the available tools (simulations, measurements, experience and knowledge) into an intelligent material-based control system. To circumvent these limitations, the SENARIO project proposes the development of a revolutionary sensing systems linked to intelligent process control equipment and reliable methodologies of aerostructures component maintenance.The proposed system consists of:- a portable curing process console with blanket-mounted dielectric sensors;- wireless non-intrusive dielectric sensors for monitoring adhesive state;- reliable laser technology for increased automation;- optical sensors complementing the dielectric sensors;- thermomechanical monitoring set-up;- intelligent process guidance system for co-cured components;- integrated multi-zone repair control unit, and;- application of bonded repairs with reliability, controlled quality and certification potential.The proposed novel multi-zone integrated process control scheme gains full benefit from the use of multi-sensory devices and the deployment of existing process knowledge (cure and stress development). The scheme enables in situ monitoring of bonded repair and resulting adhesion quality through the repair process, while offering a potential tool for non-intrusive structural health monitoring.The main innovations reside in:- the use of durable dielectric sensors in the repair process for real-time assessment of in-patch conditions;- the wire-free dielectric sensor capable of measuring remotely changes in adhesive electrical properties.- intelligent process guidance algorithm for optimal repair process conditions i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Synapse Nanomap' to be submitted under Seventh Framework.

assistant: **Abstract**

Stimulated Emission Depletion (STED) microscopy is one of the most important recent developments in light microscopy (Willig et al., 2006, Nature 440:935-9). STED allows for imaging cellular elements with diffraction-unlimited resolution; in practical terms, the resolution (normally limited to ~200-300 nm) is improved down to 30-60 nm. Together with the development of two-color STED microscopy (Donnert et al., 2007, Biophys J. 92:L67-9), this technique allows experimenters to pinpoint the position of various cellular elements with nanometer precision. Obtaining a cellular nanomap is not feasible with conventional light microscopy, due to its low resolution. Electron microscopy cannot be applied, as its labeling efficiency it too low. I propose here to use STED microscopy to characterize the positions of the major components of the synapse. The preparation will be cultured hippocampal neurons, which have numerous small (about one micron in diameter) synaptic nerve terminals. I will determine the locations of synaptic proteins involved in neurotransmitter release, in membrane retrieval and in pre- and post-synaptic active zone structure. Less specialized elements such as the cytoskeleton, mitochondria and endosomes of the synapse will also be investigated. The work will provide answers for a number of questions in the neuroscience field, such as how and where the synaptic vesicles get retrieved, how pre- and post-synaptic active zone elements correlate, and what the role of cytoskeletal elements is in synaptic transmission. The small size and relatively low complexity (compared to whole cells) of the synaptic boutons will allows the work to be completed within a reasonable timeframe. Successful completion of the project will encourage researchers to perform larger scale c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Computer integrated system for shoe last manufacturing' to be submitted under Fourth Framework.

assistant: **Abstract**

- Standard shoe last block shapes- Grading system and toolpath/surface calculation algorithms for CNC machinery- Injection prototype- Water cooling system.This project fits in the shoe last manufacturing sector frame work, and more specifically in Last manufacturing (piece of high density plastic with the shape of the final shoe used to make it by placing the different parts around it). There are specific machines which deal with each of the processes to make a Last. However two problems can be pointed out: Deficiencies in the plastic injection machines (unnecessary oversising of the mould and complete lack of quality control) and the absence of electronic or computer systems which could allow a planning coordination control of the whole process. So we identified three main objectives to be achieved: generation of a new standard in moulds shape and quantity, improvement of injection by closed loop control and quality control, and the integration of CAD/CAM systems using the new standards generated. More accurately it will produce from the industrial point of view: costs reduction in` last injection, time reduction in mould change, quality controls, reduction of plastic residum, increase of production by automatic size change machinery and system planning and production control. From the social point of view it will improve the working conditions (last turning and injection), leaving repetitive and organizational tasks, such as controlling the moulds changes. There are four SMEs involved in this project: two last production SMEs (Eurohorma and Taruplast), one machinery SME which have great interest in solving these problems (Arbo) and one shoe production SME as final user of lasts (Alta moda Calzado). On the Other hand, There are three RTDs a Research Institute whose act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural basis for the therapeutic efficiency of optimal-affinity T cell receptors', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Demographic change includes population ageing, and incidence rates begin to increase for many types of cancer in middle-aged and elderly people. Traditional cancer treatment includes surgery, chemotherapy, and radiation therapy, while tumour immunotherapy by T cell receptor (TCR) gene transfer represents an alternative form of treatment. The transfer of tumour-specific TCR genes into patient’s peripheral blood lymphocytes targets cancer specifically and effectively. But while patient-derived low-affinity TCRs do not show therapeutic activity, optimal-affinity TCRs, as isolated from newly-generated antigen-negative humanized mice with a diverse human TCR repertoire, can effectively delay tumour regression. X-ray crystallography is a powerful tool of structural biology, which helps researchers to identify the three-dimensional (3D) structures of biological macromolecules such as TCRs complexed to their cognate peptide-loaded major histocompatibility complex (pMHC) molecules. Recent research uncovered the docking topologies of naturally selected TCRs, but therapeutically efficient optimal-affinity TCRs recognizing tumour-associated self-antigens, have not been analysed to date. The exceptional specificity of TCRs is determined by three complementarity-determining regions (CDRs) of the TCR alpha- and beta-chains. Biomedical research on TCR gene therapy and design of future clinical trials will hugely benefit from the identification of CDR-mediated contact points made between therapeutic TCRs and the pMHC on their target cells. TCRabX is an interdisciplinary research project investigating the 3D structures of 13 TCRs complexed to MHC-I or MHC-II, respectively. It connects innovative clinical immunology research in Berlin/Germany and world-class structural biology research in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Co-Create Change in Research Funding and Performing' in the context of a Horizon 2020 call.

assistant: **Objectives**

Co-Change strengthens transformative capacity and leadership for RRI through an innovative systemic approach, centred on the concept of change labs, building on years of solid experience. The project activates change coalitions around each lab, paying particular attention to interactions and dependencies of actors in each R&I ecosystem, since research performing (RPOs) and research funding (RFOs) organisations co-evolve in and with the R&I ecosystems they are embedded in. This embeddedness forms the social and institutional context, which either supports or slows down changes in the system. By implementing change labs in their ecosystems, we generate transformative capacity for institutional change in terms of practices, procedures, rules and norms at the individual, organisational and system levels.Co-Change supports the implementation of institutional changes of R&I actors within and beyond the key areas of RRI. Our consortium members of RPOs and RFOs across Europe act as change agents. We set out to establish change labs as instruments for promoting and sustaining institutional change within our own organisations and reach out to actors in our innovation ecosystems. As well as co-creating RRI practices in our own organisations, we also do so in organisations that have signalled their interest. Since these include partners from research performing, financing and governance institutions, we can build change coalitions at national and EU scale. The outcomes of all change labs will be analysed to produce a toolbox and field book for RRI related institutional changes which will be broadly disseminated by committed multipliers. To widen our impact, we publish a call for innovative RRI practices, inviting more European organizations to Co-Change activities. Our project also
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'MMP and Mirrors via Maximal Modification Algebras' under Horizon 2020.

assistant: **Concept**

Geometrically, this proposal is concerned primarily with Calabi--Yau threefolds, their (local) classification, their homological properties, various associated structures such as stability conditions and Frobenius manifolds,  and the resulting predictions across mirror symmetry.  Our approach to these problems is through noncommutative algebra, and necessarily so.  We will use techniques from contraction algebras and noncommutative resolutions to classify, using both theoretical and constructive methods, and in the process verify an amended version of a string theory prediction.  We will use this to push forward curve-counting and derived category consequences and obstructions, and will work towards building a full database of 3-fold flops.    On a parallel track, we will treat fundamental problems in noncommutative resolutions and their variants, and approach some of the founding conjectures in the area.  We will tackle problems such as existence of MMAs through to more specific problems such as faithful actions and K(pi,1) through stability manifolds and tilting theory on preprojective algebras.  We will furthermore merge all this into an emerging theory of Frobenius manifolds, SKMS, and schobers, and through this expand on recent work constructing mirrors to various flopping contractions.


**Keywords:** Noncommutative resolutions, contractions, stability conditions, finite dimensional algebras