RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'CO2 Site Closure Assessment Research' to be submitted under Seventh Framework.

assistant: **Abstract**

CO2CARE aims to support the large scale demonstration of CCS technology by addressing the research requirements of CO2 storage site abandonment. It will deliver technologies and procedures for abandonment and post-closure safety, satisfying the regulatory requirements for transfer of responsibility. The project will focus on three key areas: well abandonment and long-term integrity; reservoir management and prediction from closure to the long-term; risk management methodologies for long-term safety. Objectives will be achieved via integrated laboratory research, field experiments and state-of-the-art numerical modelling, supported by literature review and data from a rich portfolio of real storage sites, covering a wide range of geological and geographical settings.CO2CARE will develop plugging techniques to ensure long-term well integrity; study the factors critical to long-term site safety; develop monitoring methods for leakage detection; investigate and develop remediation technologies. Predictive modelling approaches will be assessed for their ability to help define acceptance criteria. Risk management procedures and tools to assess post-closure system performance will be developed. Integrating these, the technical criteria necessary to assess whether a site meets the high level requirements for transfer of responsibility defined by the EU Directive will be established.The technologies developed will be implemented at the Ketzin site and dry-run applications for site abandonment will be developed for hypothetical closure scenarios at Sleipner and K12-B. Participation of partners from the US, Canada, Japan and Australia and data obtained from current and closed sites will add to the field monitoring database and place the results of CO2CARE in a world-wide perspecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Firm Growth and Market Power in the Global Economy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

According to the European Commission, to design effective policies for ensuring a “more dynamic, innovative and competitive” economy, it is essential to understand the decision-making process of firms as they differ a lot in terms of their capacities and policy responses (EC 2007). The objective of my future research is to provide such an analysis. BIGlobal will examine the sources of firm growth and market power to provide new insights into welfare and policy in a globalized world.Much of analysis of the global economy is set in the paradigm of markets that allocate resources efficiently and there is little role for policy.  But big firms dominate economic activity, especially across borders. How do firms grow and what is the effect of their market power on the welfare impact of globalization? This project will determine how firm decisions matter for the aggregate gains from globalization, the division of these gains across different individuals and their implications for policy design. Over the next five years, I will incorporate richer firms behaviour in models of international trade to understand how trade and industrial policies impact the growth process, especially in less developed markets. The specific questions I will address include: how can trade and competition policy ensure consumers benefit from globalization when firms engaged in international trade have market power, how do domestic policies to encourage agribusiness firms affect the extent to which small farmers gain from trade, how do industrial policies affect firm growth through input linkages, and what is the impact of banking globalization on the growth of firms in the real sector. Each project will combine theoretical work with rich data from developing economies to expand the frontier of knowledg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Focused Targeting of Inhaled Magnetic Aerosols for Lung Cancer' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The pulmonary tract is an attractive route for direct treatments of lung diseases. Yet, our ability to confine the deposition of inhalation aerosols to specific lung regions, and notably local airways, remains still widely beyond reach with common inhalation therapy. It has been hypothesized that by coupling magnetic particles to inhaled therapeutics the ability to locally target airway sites can be substantially improved. Yet, virtually all practical implementations to date have come short of delivering efficient localized airway targeting. Here, we demonstrate an engineered inhalation framework to leverage magnetically-loaded aerosols for airway targeting in the presence of a custom-designed external magnetic field. By coupling the delivery of a short pulsed bolus of sub-micron (~500 nm diameter) droplet aerosols, laden with super-paramagnetic iron oxide nanoparticles (SPION), with a custom ventilation machine that tracks the volume of air inhaled past the bolus, focused targeting can be maximized during a breath-hold manoeuvre. Our aerosol inhalation platform allows for the first time to deposit inhaled particles to specific airway sites while minimizing superfluous deposition across the respiratory track. This represents a dramatic effort to augment the targeting efficiency (i.e. deposition ratio between targeted and untargeted aerosols). Our first application of focus is aimed at lung cancer. We aim to achieve point targeted delivery of chemotherapeutics directly to lung tumours and lesions through inhalation, thus increasing effective doses and dramatically reducing side effects, in particular relative to detrimental systemic toxicity. AEROTARG embodies a significant paradigm shift in drug delivery modalities aimed for lung cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Single Molecule Study of Protease Mechano-Specificity'.

assistant: **Innovation**

Single-molecule enzymology offers new possibilities to dissect catalytic reactions that were previously unapproachable using biochemistry techniques conducted in the bulk. In particular, recent discoveries conducted at the single molecule level, such as the unanticipated force-mediated protein degradation pathway in the proteasome, highlight the close relation between mechanical forces and proteolysis in vivo. While much has been discovered about protein enzymology in the recent decades, the question of how mechanical force affects enzymatic catalysis remains vastly elusive. The main goal of this proposal is to understand the mechanobiology of proteolysis at the single molecule level. We will use the newly developed force-clamp spectroscopy technique, together with molecular biology engineering techniques and bioinformatics structural analysis to elucidate the molecular mechanisms that underlie protease catalysis under mechanical force. Successful enzymatic activity relies on the enzyme:substrate (E:S) assembly. Upon mechanical unfolding, proteins unveil their buried substrate sites, also called cryptic sites, thus favoring the formation of the E:S complex and ultimately permitting the subsequent chemical reaction. A key feature of recent mechano-chemistry experiments at the single bond level is that the rate at which the reduction of a protein disulfide bond occurs in the presence of a nucleophile is exponentially dependent on the stretching force. Hence, it is tempting to speculate that, in the case of an enzymatic reaction, the catalytic rate will be also force-dependent. We anticipate that the curved geometry of the bound substrate inhibits the E:S assembly at high-forces, implying a novel mechano-specificity character of proteases. Within a multidisciplinary approa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ORTHOpaedic treatment with ALLOgenic combined ATMP in long bone fracture delayed UNION and non-union (ORTHO-ALLO-UNION).' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Bone fracture with delay or failure to heal is a condition with huge health impact. Although only a small proportion of long bone fractures evolve to non-union (5%), it is a first magnitude problem due to the number of new annual fractures and increasing incidence of complex fractures with high risk of non-consolidation, need for repeated procedures and years of patient disability. Bone autografts, autologous mesenchymal cells, or other complex interventions are used in this setting. The aim of this project is the development of a universal therapy for fractures with delay or failure to heal, aiming to a simple and wide access to allogenic cell therapy combined with biomaterial, in a broad number of patients. Rather than considering ATMP only as a last solution in established non-union fractures, this project advocates that the indication should be moved to an earlier timepoint. Patients will be treated with the combined ATMP as soon as the need for reoperation is identified due to delayed healing, with or without an added infectious component, to avoid long-term suffering for patients and their relatives, and prevent progression to more severe non-unions, with heavy personal, social and economic costs. This approach is aligned with the real needs of patients and better fits with the usual practice in the EU, where reoperations are performed at 6 months or before, in an attempt to accelerate bone healing and avoid complications. The project will establish a master cell bank for a wide allogenic production with donors selection criteria of bone formation potential. Necessary preclinical and clinical information to support the EU approval of a specific combined ATMP will be obtained. Open access to scientific and regulatory information will be available for other EU medic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'All we are researchers 2'.

assistant: **Concept**

The aim of second edition of Researchers’ Night project in Serbia is to enhance public recognition of researchers and their work and to demonstrate that researchers are part of the society and that society needs researchers. All we are researchers, edition II project is envisaged to raise awareness of general objectives prior to the event, organize festive and innovative activities during the event in three main cities in Vojvodina (Novi Sad, Zrenjanin and Subotica) and monitor and disseminate the results during and after the event in order to promote closeness and interaction between researchers and the public at large through an integrated approach that will promote science as a field of work fundamentally important to our lives and our future, and researchers as people who solve the current problems of our society.Project is targeting public at large, regardless of their age, educational and scientific background. Venues are chosen in city centers, close to the main pedestrian zones. The activities organized during the night will offer a balanced combination of science-linked activities (demonstrations, simulations, hands-on experiments) and festive ones (games, sports, quizzes, competitions and music).""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Marine Aerosol NUcleations' under Seventh Framework.

assistant: **Concept**

The topic of this proposal is the natural marine aerosol, which is of paramount importance at the global scale and influences the Earth’s radiative budget and the biogeochemical cycles. New particle formation dominates the atmospheric aerosol number budgets and most of these particles are formed by nucleation of marine biogenic vapours. MANU (Marine Aerosol NUcleations) aims to directly identify the spontaneous creation of new nanometer-sized particles in the open ocean marine atmosphere and to understand the physical and chemical transformations occurring in them once formed. MANU will (1) obtain the spatial variability of new particle formation (NPF) events in different open ocean areas, (2) elucidate the chemical composition of NPF events, (3) associate NPF events with biological processes and (4) interpret how NPF events affect the existing aerosol and its overall Cloud Condensation Nuclei (CCN) population. The approach involves state-of-the-art mass spectrometry measurements including ATOFMS, HR-ToF-MS and Api-ToF/MS during a Southern Ocean research cruise (Hesperides, 2014) and at the Mace Head research station (Ireland, 2015). The expected outcome of this Marie Curie action is to contribute to a significant step in the career of the promising European researcher such as the candidate, specifically adding missing complementary research competencies at an advanced level of new particle formation events measurements. Additional benefits to the European knowledge-based economy and society will also come from the important return phase of the project, where the experience and the knowledge acquired as well as the contact-network built up outside Europe will be shared. This proposal is multidisciplinary because two institutions with different backgrounds (outgoing: atm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Needle-free injection with supersonic microjets'.

assistant: **Innovation**

When focusing a laser pulse in a liquid, a vapor bubble can instantaneously (< 1μs) be produced.We have generated such vapor bubbles in a liquid-filled coated micro-capillary (diameter≈ 50μm). Remarkably, in about one microsecond after vapor bubble formation, an ultra-high-speed, ultra-sharp, focused liquid micro-jet emerged out of the meniscus at the end of the micro-capillary.Even with laser pulse energies comparable to those used in laser-pointers, we have reached spectacular supersonic velocities up to 800 m/s. The diameter of the jets was a few micrometers, more than 10 times smaller than the diameter of the micro-capillary. These supersonic ultra-sharp microjets have tremendous application perspectives for needle-free injection of vaccines and drugs for both humans and animals. The objective of this proposal is to verify the innovation potential of this idea.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Safe and easy retrofit with energy efficient LED-tubes' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

LED is an energy-saving trend in lighting technology and offers more and more solutions to replace the fluorescent tube.Unfortunately, the change from these tubes to LED-tubes is much more difficult than the replacement of light bulbs by LEDbulbs. This resulted in a trend which is a waste of resources and harmful to the environment: The whole luminaire (lightfitting including casing, glass etc.) is disposed and replaced by an ‘integrated LED luminaire’ which has to be replaced in 5-7years. We have more than 2300 Mio. fluorescent tubes in Europe. This trend produces a giant pile of expensive electronicscrap and wastes money. Our company is going to change the game: We developed a tiny box which allows to upgrade aluminaire for fluorescent tubes to an efficient LED-luminaire which works with 230V LED-tubes. Earlier, this modification wascritical for safety reasons. After the modification, an inadvertently inserted fluorescent tube would blast if there was not ourinnovation: The patented M OLED®-Box solves the safety issue and allows electricians to retrofit the existing luminaire without therisk of injury of the users. The necessary re-certification is easy, because the M OLED®-Box is a certified component andour company delivers a helpful how-to manual in the electricians national language. The modification itself only needs 5-10minutes. The M OLED®-Box (made in EU) has a market price of approx. € 15.-. The production is rather simpleand the business model can be scaled up quickly. The potential market size is € 1000 Mio / yr. In Phase 1, the project goal isto survey the targeted markets France, Poland, Spain, Sweden and UK. Together with Austria and Germany they build starting points to conquer the whole European market. The information obtained is the base for the feas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Nanoengineered Chemical Synthesis Inside Restricted Volume of Nano- and Microsized Polyelectrolyte Capsules' (NANOCAPSULE) under Sixth Framework.

assistant: **Objectives**

The idea of the proposed project is to employ hollow polyelectrolyte capsules as spatially-confined microreactors for synthesis of composite inorganic nanomaterials. Recently introduced, these capsules are made by layer-by-layer adsorption of oppositely charged polyelectrolytes on the surface of template nanoparticles with sequential removal of the template core. Polyelectrolyte capsules can act as excellent microreactors for carrying out physico-chemical processes (nanoparticle precipitation, biomineralization, biomimetic synthesis, photocatalytic synthesis, etc.) in their spatially restricted volume. The possibility of varying shell components and capsule size gives a considerable diversity in synthetic approaches and initial reagents while selective and controllable permeability of the capsule wall, which is a key factor for performing chemical reactions exclusively inside the capsule volume, allows to control diffusion of the reagents and reaction kinetics. The main project objectives are:1) to understand mechanism of physico-chemical reactions in restricted capsule volume and to figure out parameters of crucial influence (shell, volume composition; capsule size; etc.) on the reaction kinetics and properties of resulting nanomaterials;2) to fabricate new composite nanomaterials and to study their properties in comparison with properties of analogous nanomaterials obtained in bulky water solution;3) to realize enzyme-containing polyelectrolyte capsules as semipermeable enzyme-driven nanoreactors for biomimetic synthesis of inorganic materials.Proposed project is a multidisciplinary one and its results can be of interest for scientists from material science, biotechnology, nanotechnology, life science, catalysis, medicine, and environmental chemistry. The proposed pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrated innovative metallurgical system to benefit efficiently polymetallic, complex and low grade ores and concentrates' (INTMET).

assistant: **Innovation**

The INTMET approach represents a unique technological breakthrough to overcome the limitations related to difficult low grade and complex ores to achieve high efficient recovery of valuable metals (Cu, Zn, Pb, Ag) and CRM (Co, In, Sb). Main objective of INTMET is applying on-site mine-to-metal hydroprocessing of the produced concentrates enhancing substantially raw materials efficiency thanks to increase Cu+Zn+Pb recovery over 60% vs. existing selective flotation. 3 innovative hydrometallurgical processes (atmospheric, pressure and bioleaching), and novel more effective metals extraction techniques (e.g. Cu/Zn-SX-EW, chloride media, MSA, etc) will be developed and tested at relevant environment aiming to maximise metal recovery yield and minimising energy consumption and environmental footprint. Additionally secondary materials like tailings and metallurgical wastes will be tested as well for metals recovery and sulphur valorisation. The technical, environmental and economic feasibility of the entire approaches will be evaluated to ensure a real business solution of the integrated INTMET process.INTMET will be economically viable thanks to diversification of products (Cu, Zn, Pb), high-profitable solution (producing commodities not concentrates), with lower operation and environmental costs (on-site hydroprocessing will avoid transport to smelters) and allowing mine-life extension developing a new business-model concept based on high efficient recovery of complex ores that will ensure EU mining industry competitiveness and employment.INTMET is fully aligned with EIP-RM validated in the PolymetOre Commitment where most of INTMET partners take part on and the market up-take solutions are guaranteed by an exploitation from industrially-driven consortia composed by 3 Mines,