RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A european public space observatory: assembling information that allows the monitoring of european democracy' to be submitted under Fifth Framework.

assistant: **Abstract**

A democratically viable Europe requires a 'public space' or 'public sphere' as an institutionally delimited space of citizen interaction. The EUROPUB project will examine whether a public space is currently emerging at European level. It analyses whether and how present institutional structures and political and policy-making practices at EU level provide an effective system of political contestation. EUROPUB will also devise a set of empirical indicators designed to monitor and observe the development of a European public space over time.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'NLF Starboard Leading Edge & Top cover design & manufacturing Trials'.

assistant: **Innovation**

The Natural Laminar Flow (NLF) aerofoil is a potential key technology for the next generation of aircraft, improving the performance by reducing drag, and hence reducing emissions.The requirements of a NLF wing differ significantly from a conventional turbulent wing, requiring changes to both the wing architecture, aerofoil definition and the detailed design and manufacturing concepts.  The performance of a NLF wing requires very tight surface roughness and waviness tolerances and contamination free surfaces in the areas where laminar flow is to be maintained.  NLF wings also require alternative Leading Edge (LE) moveable concepts, novel LE/Wing-box joints, and slender LE sections.This proposal is for the design of the starboard LE and Upper cover for a NLF Wing flight demonstrator. The current baseline solution is a metallic LE and composite Top Cover.  The LE and Top cover will be joined to a wing-box (outside of scope) and attached to the flight test demonstrator which will be an A340, with the outer third of a starboard wing (from Rib 28 to wingtip) replaced.The demonstrator aims to validate that a jointed wing concept (LE + Top cover) can be manufactured in realistic high rate and repeatable conditions appropriate to a civil short range aircraft to the required level of aerodynamic surface quality to achieve laminar flow.From experience on existing Clean Sky Smart Fixed Wing Aircraft (SFWA) calls, current LE and Top Cover design and manufacture capability, and thorough investigation into the Call, GKN recognise the very demanding tolerance and hence manufacturing requirements to achieve a successful demonstrator outcome.It is understood that any proposed solutions, for LE or Top Cover design, must be developed and proved to such a level that the components can obta
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Genomics of Ageing in Elephants: Genomic architecture of senescence in a long-lived mammal'.

assistant: **Objectives**

European populations are ageing, and this has important health, economic and social consequences. Yet in order to manage these, we need to understand the complex phenomenon of ""biological age"", and in particular its genetic determinants. It is now established that longevity insurance genes such as TP53 mitigate the roles of mitochondrial function, oxidative stress and telomere shortening, and that these genes are also involved in ageing, with senescence and cancer being two faces of the cell growth balance. Thus, longevity is a trade-off between cancer and ageing, but also possibly fertility and menopause. In that respect, Asian elephants are a fascinating model: similar to humans in lifespan, senescence, and selection for grandmotherhood, they are almost exempt of cancer, contrary to predictions based on their large size. Recently, multiple retrocopies of TP53 have been identified in elephants: a strong argument to consider that cancer-avoidance and a long lifespan are the product of genetic adaptations in proboscideans. The genetic architecture of human-like ageing is impossible to study in classical short-lived models, as they lack the traits that make human life-history special, like a post-reproductive lifespan. Therefore, I propose to use a unique century-long dataset on life-history and health records for thousands of Asian elephants, currently explored by Prof. Lummaa's international-level team through behavioural ecology and ecophysiology at University of Turku. Together with my secondment host Prof. Bertorelle at University of Ferrare, I will apply my skills in cutting-edge genomic methods to disentangle the hereditary and individual determinants of ageing in long-lived mammals. By bringing these different competences together on a one-of-its-kind dataset, I
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hybrid Spintronic Synapses for Neuromorphic Computing' (SPIN-ION).

assistant: **Innovation**

At Spin-Ion Technologies we develop a new manufacturing solution based on ion beam processes to precisely engineer magnetic materials at the atomic scale. This result enables the development of new neuromorphic chips based on low power synapses composed of magnetic devices that can overcome both catastrophic forgetting and reduce device variability, hence greatly advancing the development of highly efficient, robust hardware amenable to neural applications on the edge.Our transition project involves both hardware & software developments to demonstrate implementation of an Artificial Neural Network on a magnetic chip, which will bridge computational neuroscience and deep learning while generating strong impact for future embedded and neuromorphic systems. This project also covers all necessary steps for full commercial readiness, including problem/solution validation, market research, competition analysis, establishing IP strategy, ensuring regulatory compliance, stakeholder engagements, dissemination activities, construction of a detailed business plan and securing future funding.


**Keywords:** Neuromorphic, artificial synapse, artificial neural network, binarised neural network, spintronics, metaplasticity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Macroporous Polymer Monoliths as a Low-Cost Bioanalytical Platform for Biopharmaceutical Glycoprotein' (PoreSelect).

assistant: **Innovation**

Glycoprotein therapeutics are widely seen as the next generation of drugs. 80% of new therapeutic drugs in phase 3 development are ‘biologics’. However, the early detection of critical glycosylation changes in biopharma pro-duction (i.e. in the drug producing cells) and the rapid and sensitive identification and separation of closely relat-ed protein-drug glycoforms presents an industry wide problem. This project aims to develop a low-cost and easy-to-produce glycopeptide separation platform. This will be based on highly porous polyHIPE structures obtained from fast and scalable polymerisation and subsequently functionalised with reactive groups. The latter will be employed in the conjugation with novel recombinant lectins that have very selective carbohydrate-binding prop-erties. The separation of closely related glycoproteins will be investigated. Moreover, the integration of the lectin conjugated porous polymers into a device format will be addressed. This is a highly interdisciplinary project at the interface of polymer and material science, biotechnology and separation science. The applicants diverse experi-ence in academic and industrially informed projects makes him an ideal match for this project. It provides a unique environment for the researcher to develop his skills supported by unique scientific and complementary training and accelerate his academic career in applied material science. The dissemination of research results will target the professional audience as well the general public through outreach activities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of dynamic JNK signalling in balancing cell removal and renewal in a stressed epithelium' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Tissue homeostasis requires a tight maintenance of cell number. Little is known about how tissue size and cell numbers are maintained in stress situations, when additional proliferation is needed to compensate for cell loss. I propose to study the homeostatic response to stress in a tissue (Drosophila wing primordia) in which Ribosomal Proteins-deficiency causes extensive apoptosis compensated by extra proliferation. How are these two responses balanced to ensure the emergence of a normal adult organism? JNK signalling is a strong candidate to mediate both apoptosis and proliferation responses. I propose to decipher the regulatory events that control this two-faced response, and to identify the proliferative pathways activated by JNK. Using the latest tools of genome engineering and live imaging, I aim at unravelling the spatio-temporal dynamics of JNK signalling and the downstream activation of cell death or division. Next, I will use a candidate gene and an unbiased approaches to uncover the transcriptional programs that correlate with apoptosis and proliferation. Lastly, I will verify the relevance of the identified candidates and investigate their spatial-temporal activity upon JNK activation. The results will be key to reaching the next stage of understanding the role of JNK in orchestrating the concerted replacement of lost cells that ultimately results in functional epithelia. Uncovering this logic in a relatively simple epithelium will hopefully guide further studies in more complex tissues of direct biomedical relevance.


**Keywords:** JNK signalling dynamics / stress response / compensatory proliferation / live imaging / transcriptomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Architecture for Unified Regional and Open digital ecosystems for Smart Communities and wider Rural Areas Large scale application' (AURORAL).

assistant: **Innovation**

Lower population and business density make it more challenging to develop private businesses and public services in rural areas, negatively impacting socio-economic indicators. Rural areas are key to solve climate change, food, biomass and energy challenges. Favourable climate for entrepreneurship is needed for better provision of jobs, basic services, including health and care, connectivity, smart transport, energy solutions and attractiveness as whole, overcoming digital divide between rural and urban areas. AURORAL focus on delivering a digital environment of interoperable services through platforms able to trigger dynamic rural ecosystems of innovation chains, applications and services. Thus, AURORAL contributes to increasing economic growth in rural areas and to tackle significant societal challenges. AURORAL digital environment is demonstrated by cost-efficient and flexible cross-domain applications through large-scale pilots in five European regions. AURORAL digital environment builds on an open, API-based, interoperable and federated IoT architecture and includes a reference implementation supporting flexible integration of heterogeneous services, bridging the interoperability gap of the smart object platforms and creating markets for services in rural areas. AURORAL digital environment addresses the integration of data and information across different platforms, establishment of an open market place, large-scale demonstration, multiplication of novel applications, the leverage of infrastructure and inclusion of public services. AURORAL pilots follow an evolutionary agile, well-delineated, and lean approach demonstrated in large-scale applications capable of meeting social and economic objectives critical to boost new rural services and business. AURORAL digital
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'HIGH PERFORMANCE POLYHYDROXYALKANOATES BASED PACKAGING TO MINIMISE FOOD WASTE' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The main objective of YPACK is the pre-industrial scale up and validation of two innovative food packaging solutions (thermoformed tray and flow pack bag) based on PHA, with active and passive barrier properties. New packaging will use food industry by-products (cheese whey and almond shells), assure the biodegradability and recyclability, and reduce food waste, in the frame of the EU Circular Economy strategy.YPACK will use a holistic approach and methodology involving different knowledge areas: Development of packaging solutions (Production of PHBV layers, compounding, prototyping, Industrial Validation), Product Validation (Quality / Shelf life), Social approach (Customer profiling, Dissemination, Policies & Regulatory) and Market Assessment (Business study and Risk assessment). YPACK is aligned with the EU Circular Economy strategy, including the use of raw bio-based food industry by-products, LCA studies, recyclability & biodegradability of packaging and trying to reduce Food Waste. The project is constructed in line with the Responsible Research and Innovation guidelines of the European Commission.The project has a total duration of 36 months. Several processes related to the production of multilayered passive and active systems based on raw PHBV will be optimised and scaled up to pre-industrial size to validate the production of the proposed packaging solutions for extend the shelf life of selected food products. They consist in:i) a multilayer tray involving an inner active layer, and ii) a multilayer flow pack with improved barrier properties. A consumer profiling and market study will be performed at the first stage of the project in order to identify consumers´ preferences, market needs and match them with the new EU regulations and packaging materials breakt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Genomic binding of transcription factors as a function of DNA affinity and chromatin.' (2014-2020).

assistant: **Innovation**

Transcription factors (TFs) read cis-regulatory information encoded in the genome and by doing so, they establish gene expression patterns. However, TFs must compete with structural chromatin proteins such as nucleosomes for access to DNA, and this may partially explain why only a fraction of their sequence motifs in the genome are actually bound. It is unclear what features discriminate used from unused sites with similar motifs, in vivo, though it is likely that sensitivity of TFs to chromatin is critical for normal gene expression. For example, some TFs have reduced chromatin sensitivity, termed pioneer-factors, and are able to drive differentiation; even these bind a minority of cognate motifs in the genome. Such factors may nevertheless modify chromatin and expose motifs for TFs with higher sensitivity. Alternatively, chromatin proteins and modifications may be intrinsically directed by unidentified DNA sequence features. Though little is known about determines of TF-chromatin sensitivity, it is likely a function of DNA affinity and the ability to recruit chromatin-modifying activity.The complexity of chromatin/TF interactions necessitates a reductionist approach. The objectives of this project is to gain mechanistic understanding of chromatin-sensitivity and will use established methods to measure binding of ectopic TFs as a function TF properties and chromatin components. I will express exogenous TFs in mammalian cells and compare in vivo binding to in vitro DNA affinity and analyse their chromatin sensitivity (WP1). This setup enables me to modify and profile chromatin before and after expression, which will test the contribution these factors have on TF binding (WP2). Finally, I will test if manipulating the chromatin-modifying activity of an ectopic TF affects
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Gravitation, Holography and Quantum Gravity' (HOLOGRAPHY).

assistant: **Concept**

The main aim of this research project is to further the understanding of the so called Holographic Principle, originally formulated by G. t Hooft (who wrote a referee assessment of the applicant). This is a subject that is not only of great intrinsic intellectual interest but has many ramifications across wide areas of physics and mathematics. The Holographic Principle gives a precise, general and surprisingly strong limit on the information content of space-time regions: the total number of independent quantum states grows exponentially with the surface area rather than with the volume of the system. Considering that progress in fundamental physics has often been driven by the recognition of a new principle-examples include the relativity and the equivalence principle- the direction offered by the Holographic Principle is definitively impacting existing frameworks and provoking new approaches. Any theory which incorporates the Holographic Principle must unify matter, gravity and quantum mechanics.The Holographic Principle conflicts with received wisdom, since it predicts a drastically smaller number of fundamental degrees of freedom than the traditional field theory estimate. It may also prove beneficial to the further development of String Theory, widely considered the most compelling of the present approaches to the Unification of Fundamental Forces. The objectives of this research project are therefore quite interdisciplinary and combine different techniques and approaches, including also investigations in the context of discrete models of quantum gravity. Project objectives are expected to be: Scattering at planckian energies, with particular interest in the corrections to the leading order approximation studied by t Hooft and many others. These corrections should
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DOWNTIME ANALYSIS FOR MARGINAL FIELD PRODUCTION SYSTEMS [PHASE 2]' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

'DAMPS', Downtime Analysis for Marginal Field Production Systems, Phase 1 (Cct TH./03258/87) developed a system which analyses and predicts the downtime of offshore marginal fields operated via various types of floating production systems. The emphasis is on a practical approach. Environmental downtime is a critical cause of offshore production downtime. In order to bring DAMPS to the stage where it could be of practical use to an operator, model testing relative to environmental conditions was considered essential. The Scope of Work, Damps Phase 2, involved a development of Phase 1 incorporating actual model testing in 2D and 3D wave tanks, by The Danish Hydraulic Institute/Danish Maritime Institute and University College Cork Hydraulics and Maritime Research Laboratory, to assist in tuning the environmental downtime software subroutine one step further. Motion analysis information is utilised for various configurations as previously inputted into the software Knowledge Data Bases.Model test results have been gathered and inputted into the numerical simulator. Information available from the Project Technical Director.The project incorporated the following tasks:- Collation of all relevant information from DAMPS, Phase 1, and from the partners involved in Phase 2,- Specifications of the sea states to be modelled in 2D and 3D,- Specification of a comprehensive and representative range of marginal field configurations as subjects for the model testing programme,- Identification, through DAMPS, Phase 1, of a prioritised list of system components for the various marginal field configurations for subsequent model testing,- Manufacture and instrumenting of the models,- Computation of Response Amplitude Operators (RAO's) for the components and verification of these parameters