RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Embedded Multi-Core Processing for Mobile Communication Systems' (ICT-eMuCo) under Seventh Framework.

assistant: **Objectives**

ICT-eMuCo addresses the platform architecture of future mobile devices. This comprises the relevant controller elements as well as the operating system and application layers. It is expected that the computational performance needed by these devices will grow exponentially due to the growing number of features implemented and the advances in the wireless communication standards. The fast growing number of applications and the resulting diversification requires a co-existence of open and protected environments.<br/>It is therefore proposed to choose a multi-core architecture to get the best ratio of performance and power consumption while maintaining a high flexibility and scalability in the system through variations in number of cores, cache sizes, clock speeds etc. Existing multi-cores are taken as a starting point for the controller architecture. The actual implementation of e.g. the cache and memory system will be optimized to the specific needs as well as the extension by hardware accelerators for dedicated tasks.<br/>Virtualization technology will be employed to abstract the applications including potential legacy operating systems from the hardware architecture. This provides the means to separate real-time from non-real-time and secure from open domains. To account for the embedded nature of mobile devices and its limitations in performance and power consumption the virtualisation functionalities are supported by hardware where appropriate.<br/>The awareness for the existence of multi-cores must also arise at the programmer's level. This is taken care of by a model-driven code generation technology based on SDL for typical communications protocol tasks and UML for the application development and modelling.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Volatility forecasting evaluation based on loss function with well-defined multivariate distributional form and ultra-high frequency datasets' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Predicting volatility is of great importance in pricing financial derivatives, selecting portfolios, measuring and managing investment risk more accurately. Since 1980 volatility forecasting is based on day by day datasets. However, the last decade, the use of ultra-high frequency datasets provided more accurate volatility forecasts. In the case where we are interested in evaluating a method’s forecasting ability, a loss function, which takes into consideration the utility of the forecasts is mainly constructed. Although utility functions are measures of accuracy, which are constructed based upon the goals of their particular application, in the majority of the cases, their statistical properties are unknown. The superiority of a utility function against others must be judged by a statistical-theoretical ground and mot just from its empirical motivation. Even though we cannot investigate the statistical properties of a loss function, we are capable to use it for measuring whether two forecasts have statistically equal forecasting accuracy. The majority of the hypotheses tests, which exist in the forecasting literature, compare the ability of two models in producing accurate predictions. However, the simultaneous comparison of the available forecasts provides a more robust comparison of the competing methods of forecasting. The main research objective is the development of a volatility forecasting evaluation framework which would combine the state-of-the-art findings in financial and statistical literature. We seek to combine a) the recent findings in ultra-high frequency modelling, with b) the techniques of simultaneous multiple model comparison and c) the construction of a utility function (or loss function) whose statistical properties would be known.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Genome mining in Streptomyces violaceusniger, a prolific antibiotic producer' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Complex polyketides are microbial natural products (including clinically-useful medicines) whose chemical structures correlate with the sequence of the modular enzymes responsible for their biosynthesis. This unique paradigm means that the structure of the gene can be inferred from the chemical structure of the molecule, and (with less certainty) the reverse is true. Now, genome-scale sequencing of actinomycetes has revealed untapped chemical diversity in culturable streptomycetes: there are many biosynthetic clusters present but most are cryptic (silent).  Expression of biosynthetic genes is now a severe bottleneck in trying to develop a genuine “synthetic biology” of natural products, in which PKSs are designed and fabricated to order to produce a specificed target molecule. We have sequenced and will study an extreme example of “one strain-many clusters”: a strain of Streptomyces violaceusniger which houses 11 clusters (of which seven silent and some are novel). We will: (1) use in-frame PKS gene deletion followed by chemical analysis of the resulting mutants, to test whether and how inactivation of one pathway affects the simultaneous production of others;  (2) attempt to activate cryptic pathway genes by alterations in regulatory genes and by ribosome engineering, and isolate any new products;  (3) clone whole PKS clusters in high-yielding (and sequenced) strains of, respectively, the monensin-producing Streptomyces cinnamonensis and the erythromycin-producing Saccharopolyspora erythraea for heterologous expression of polyketides in “pre-optimised” backgrounds; and (4) use genome reduction triggered by cre-loxP recombination,  to radically simplify the secondary metabolite profile of all three strains and test the mutants for improved expression of cloned PKS genes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Systematic mapping of the chloroplast protein import system' (Chloro-Import).

assistant: **Innovation**

Protein import into a membrane-bound organelle in eukaryotes has been intensively studied, leading to the discovery of the central intracellular import machineries. Yet, this field has undergone a fundamental paradigm shift following recent discoveries of non-canonical import pathways in the mitochondria and ER. While the chloroplast is still thought to have but one import machinery (TIC/TOC), accumulating evidence indicate it, too, has non-canonical pathways. Technological constraints have so far barred the systematic search for alternative import pathways, as well as the exploration of central aspects relating to this import system: Are there additional import pathways other than the canonical chloroplast translocon apparatus? What ensures correct targeting of proteins in the highly crowded cytosol to the chloroplast? What mediates between quality control processes and protein import?In Chloro-Import, we will go beyond the state-of-the-art by implementing multipronged, genome-wide, unbiased approaches we developed or adopted to elucidate all the targeting pathways en route to the chloroplast in Chlamydomonas. Specifically, we will use advanced genome-wide screening to comprehensively elucidate chloroplast import pathways (Aim1); uncover the functional organization of import pathways using genetic-interaction profiling and protein-protein-interaction mapping (Aim2); and conduct an in-depth biochemical investigation of the function of unstudied/novel import factors (Aim3). To the best of our knowledge, this is the first-ever study of this scale in a photosynthetic eukaryote cell. The outcome will be a complete map of the chloroplast protein-import system (pathways, components, regulators) and a genetic platform for this system’s in-depth characterization. It will furthe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modulation of insulin-like growth factor 1 function by C-terminal E-peptides during muscle differentiation and myofibrillogenesis' under Sixth Framework.

assistant: **Concept**

Muscle weakness and loss of muscle cytoarchitecture are associated with several myopathies, many of which still of unknown genetic cause, and with other pathologic states, such as the muscle atrophy that results from aging, cancer or cardiac infarction (cardiac cachexia). Because of the changes in our life habits and in the average life expectancy of our societies, treating muscle weakness by increasing muscle mass or by boosting the regenerative potential of muscle tissue is becoming a major goal for the clinical industry as well as for healthcare agencies. Insulin Growth Factor 1 (IGF1) can play an important role in improving muscle function during diseased states or along the aging process. In fact, it can increase the regenerative potential of muscle tissue and/or stimulate local hypertrophy, an event that ultimately requires for active remodelling of the contractile apparatus.However, IGF1 regulation is particularly complex, since different isoforms of the pro-hormone have been described, differing in their C-terminal E-peptides. Overall, little is known about the events controlled by alternative IGF1 isoforms specifically in muscle cells, or their importance for remodelling/stability of myofibrillar apparatus. Elucidating any direct effect exerted by IGF1 E-peptides on muscle differentiation and myofibrillogenesis, or how they influence the modes of function of IGF1, is crucial for our understanding of this system and for our capacity to modulate it to attenuate age- or disease-associated muscle weakness.We propose the following aims:1. To characterise the events under the control of IGF1 specifically in muscle cells;2. To assess the role of IGF1 E-peptides on muscle cells, either as direct effectors or as modulators of IGF1 function;3. To define the contribution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The Entrepreneurial Laboratory for teachers’ training. A Capability Approach for Entrepreneurship Education in Vocational education'.

assistant: **Innovation**

The aim of this project is to create a model for continuous teachers’ training on entrepreneurship education, provide guidelines and best practices on the pedagogies conductive for entrepreneurship education in vocational education. The Entrepreneurial Laboratory will be composed of workshops with the participation of teachers in vocational education and the various stakeholders that will discuss how to implement entrepreneurship education in the specific vocational setting chosen for the research. The focus will be on the pedagogies teachers will establish in order to encourage, facilitate and support their students being entrepreneurial in and outside the school environment. Within Europe 2020 entrepreneurship is considered particularly important as it can tackle youth joblessness and favour social inclusion. While changing the educational system is not an easy process, steps must urgently be taken to implement short, medium, and long term agendas that a move education in the right direction to match Europe 2020 objectives. The literature on entrepreneurship education and the government documents highlight the need to improve the quality of entrepreneurship education in vocational secondary schools through a switch of the pedagogies (teaching methods and didactics) and the creation of conditions for students to show sense of initiative and entrepreneurship in and outside school.In line with a capability approach the final goal will be increasing students’ autonomy and ability to make choices. With this post doctoral research comprising scientific publications plus experience in teaching and supervising students, as well as more entrepreneurial competencies the Experienced Researcher will be ready for associate professorship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart strategies for the transition in coal intensive regions' (TRACER) under Horizon 2020.

assistant: **Objectives**

The overall objective of TRACER is to support a number of coal-intensive regions around Europe to design (or re-design) their Research and Innovation (R&I) strategies in order to facilitate their transition towards a sustainable energy system. TRACER consortium partners have been carefully selected to involve organisations with complementary expertise and excellent long-term collaboration contacts with key public and private stakeholders of important coal intensive regions, proven by 40 Letters of Support provided during proposal preparation. Good geographical coverage among countries and regions with high dependence on coal production and use has been ensured through the inclusion of seven target regions in EU Members States (South East Bulgaria, North West Bohemia - Czech Republic, Lusatian Lignite District - Germany, West Macedonia - Greece, Upper Silesian Coalfield - Poland, West Romania, Wales - UK), and two in countries outside the EU (Kolubara - Serbia, Donetsk - Ukraine). Core activities of TRACER include the Implementation of an EDP (Entrepreneurial Discovery Process) to mobilise a wide range of stakeholders in each target region to develop an appropriate governance structure and to bring regional stakeholders together to discuss and agree on a shared vision and priorities for coal transition. R&I strategies, industrial roadmaps and decision support tools will be developed jointly with key stakeholders of the TRACER target regions. Further TRACER activities include the identification and analysis of best practice examples of successful and ambitious transition processes in coal intensive regions, a detailed assessment of social, environmental and technological challenges, the elaboration of guidelines on how to mobilise investment as well as dedicated activitie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Compositional Higher-Order Reasoning about Distributed Systems'.

assistant: **Objectives**

Software systems are critical for the infrastructure of modern society and software errors and security breaches pose enormous costs and risks. The traditional method of testing software systems is famously inadequate for guaranteeing the absence of errors and security breaches since not all execution paths are covered by testing. This is espcially true for concurrent and distributed systems, where there are simply too many execution paths to test, and it has motivated research in formal methods for program verification that can offer mathematical proofs that all system behaviors meet some desirable property.  To formally analyze and reason about software systems it is important to consider models at many different levels of abstraction. Since many real software errors and security breaches stem from subtle problems in implementations of software systems, we focus on detailed, so-called semantic, models of program execution.  While there has been much research on abstract models for reasoning about distributed systems, there has been very little work on compositional verification of implementations of distributed systems. Compositional verification enables specification and verification of individual software modules and their composition, and is key to achieving scalable methods that apply to large programs, but the devel- opment of logics and methods for compositional reasoning is hard.  For concurrent, non-distributed, programs there has been tremendous progress in the last decade on program logics for compositional verification, in particular through the development of so-called higher- order concurrent separation logics. Leveraging this progress, CHORDS will research and develop new theories, program logics, and methods for mathematically rigorous compositional rea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Radar Classification Of Obstacles in Nature' (RaCOON).

assistant: **Innovation**

Forests cover more than 40% of Europe’s surface and are essential for biodiversity, provide fresh water, absorb carbon and preventerosion. Yet they face detrimental effects of climate change, such as wildfires or outbreaks of the bark beetle. The field of roboticsoffers a pallet of tools to help manage and monitor forests, yet mainly by flying robots. Ground robots that could carry heavierequipment and last longer struggle in vegetation since their autonomy systems have been developed for obstacle-free scenarios(e.g., driving on roads). The research proposed here, “Radar Classification Of Obstacles in Nature (RaCOON)”, aims to enable thedeployment of ground robots in forests by giving them the ability to decide which vegetation can be safely driven through. Theapplicant will deploy a new sensor modality, i.e. radar, and develop a novel sensor fusion system that will classify vegetation into theobstacle and non-obstacle categories. This additional information will allow ground robots to autonomously plan trajectories andnavigate in vegetation. The problem will be approached first by exploring the possibilities of radars in a proof-of-concept experiment.Then, a forest robotic dataset will be recorded in various types of vegetation. The experience from the proof-of-concept experimentand the recorded data will motivate the design of the final sensor fusion system. The outcomes of RaCOON will be 1) dissemination ofthe new system and dataset to the research community and professional networks, 2) training of the applicant in the deployment ofradars for mobile robots and 3) extending the applicant’s professional network and independent research capabilities, advancing him towards starting his own robust field robotics research group.


**Keywords:** Mobile robot, Radar, Autono
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sex-linked loci, sexual specialization and local adaptation in Mercurialis annua complex""' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The sexual and genetic systems of a plant species directly regulate how genes are transmitted across generations. Accordingly, their study is of central importance to understand plant evolution. Populations of widespread plants normally have higher fitness at their home site than in other parts of the range. However, the genetic and molecular mechanisms underlying local adaptation are not well understood yet. How do plant populations adapt to a rapidly changing world? Why and how separate sexes evolve and are maintained in plants? What are the consequences of broad variation in sexual systems for plant survival at different spatial scales (local, widerange)? I will conduct innovative and multidisciplinary research, using state-of-the-art sequencing technology, to investigate how natural selection brings about local adaptation in plant populations with contrasting sexual (separate vs. combined sexes) and genetic (diploidy vs. polyploidy) systems. To address these questions, I will study the ecological genomics of local adaptation in the Mercurialis annua s.l. species complex. This species complex shows an unusually broad variation in its sexual and genetic systems, as well as large phenotypic geographical variation, thus providing an outstanding model to study, at the genomic level, the role of mating and genetic factors on local adaptation. My pursuit of these objectives will make a substantive contribution to high-level science, as this project will shed light on some fundamental questions in plant sexual evolution (e.g. the genetic control of sexual-system transitions) and, more generally, on how plants adapt to rapidly changing environments. Additionally, this project will provide a profitable training opportunity at a critical period in my career. Born in 1972, I am