RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'SYNTHESIS OF AMINES FROM ALCOHOLS BY METAL-CATALYZED REACTIONS' (AMINATION) under Seventh Framework.

assistant: **Objectives**

This project is focused on the development of efficient, versatile and sustainable synthetic methodologies within the field of organic chemistry to allow preparation of simple organic compounds and its application to industrial processes. Amines are very important compounds for the chemical industry and also for several biological processes, and the discovery of new effective methods for their synthesis is still a very relevant research field. An attractive and sustainable approach is the metal-catalyzed amination of alcohols, an environmentally ideal process due to water is the only by-product and it is not necessary to use expensive and waste-generating activation agents.Nevertheless, this procedure has yet been scarcely investigated and most of the known catalytic systems require harsh conditions and are little productive and actives. For this reason, this proposal is aimed to the study of this transformation and its transfer to large-scale production in industrial processes. The first objective is to develop novel catalysts based on ruthenium and iron complexes that allow performing this reaction by using mild and chemoselective conditions. Otherwise different studies would be conducted to identify the exact operating reaction mechanism, while the scope of the amination reaction would be studied for further establishment of this methodology in organic synthesis. In addition, we have also a great interest to use chemical products based on functionalized alcohols from renewable resources (e.g. glycerol, sorbitol, etc.) which would allow for a sustainable production of novel and industrially significant amines, as well as to show the applicability of the developed methodology with the synthesis of some biologically active compounds.  Finally, a very attractive objectiv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The European Robotics Research Infrastructure Network' under Horizon 2020.

assistant: **Concept**

After a few decades of intense research and development, Robotics has produced radical innovation and impact in many sectors (manufacturing, space, medicine…). In addition Robotics has generated novel scientific and engineering knowledge. This is due to the unique nature of Robotics, that has evolved from a predominantly engineering-oriented domain, to a transdisciplinary area including and inspiring many different disciplines. Europe is an undisputed leader in Robotics: it has nurtured a large community of researchers, educated many thousand students, created large and small companies, and established advanced facilities for conducting scientific research and contributing to technological innovation. However, despite of significant efforts and achievements, the existing Robotics facilities are not fully synchronized, and lack common procedures, thus hampering their enormous potential for world class research and innovation. Creating a Robotics Research Infrastructure is realistic, timely and essential in the current and future landscape of Robotics. The European Robotics Research Infrastructures Network (TERRINet) project aims at building a world-class network with harmonised services and complementary capabilities where talented researchers from academia and industry worldwide will have access and will be able to explore new ideas and establish personal and joint projects; to get in contact with and be inspired by leading and creative scientists, technologists, experts and industrial representatives; to share information and gain knowledge for boosting their scientific research and potential for technological innovation. The plan of TERRINet is to accomplish its vision by providing not only an organised and well orchestrated set of facilities, but also databases, tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Optimisation of an on-board adsorbent/catalyst unit for aviation fuel thermal stability improvement' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The research programme proposed by the University of Sheffield experimentally investigates the application of an optimized on-board adsorbent/catalyst unit to reduce the tendency of jet fuel that contains dissolved oxygen to produce solid carbonaceous deposit in the fuel system and injection system at moderate temperature regimes. Improved fuel thermal oxidative stability offers the fuel to serve as a better heat sink, absorbing more waste heat from VHBR engines and using the heat to benefit in the engine performance cycle. This leads to more efficiency in comparison to adding extra cooling systems employing bleed air that is dumped overboard, and could yield around 2% SFC improvement in association with heat exchanger weight and volume savings. Furthermore, the elimination of overboard bleed is a potential to reduce IR signature. To achieve the programme goal, the following project objectives are proposed: 1) Optimise the size of the adsorbents/catalysts unit in small scale, bespoke experimental device with respect to flow regime and bulk fuel temperature following a Design of Experiments approach2) Simultaneous thermal oxidative stability assessment of deoxygenated fuel using low medium scale test device namely, “High Reynold Thermal Stability (HiReTS)”3) Compositional analysis of deoxygenated fuels with particular focus on side reactions 4) Fuel lubricity assessment 5) Calculation of adsorbent longevity using available quantum chemistry methods    6) Calculation of trade-off between thermal stability enhancement and lubricity decrease using available quantum chemistry methods    7) Project scale up and use of the optimised adsorbent/catalyst unit in a TRL5 scale engine representative jet fuel system simulator, namely the “Aviation Fuel Thermal Stability Test Unit (AF
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Endoplasmic reticulum stress and hepatocellular carcinoma: a new paradigm in tumor growth regulation' in the context of a Sixth Framework call.

assistant: **Objectives**

The endoplasmic reticulum (ER) is the sub-cellular compartment where secretory proteins enter the secretory pathway. This compartment is specialized for their folding and assembly. When maintenance of ER homeostasis is altered, this compartment triggers a specific signalling pathway, named the Unfolded Protein Response (UPR), which leads to translation attenuation as well as the activation of specific transcriptional programs. These mechanisms aim to facilitate cell recovery and to repair when possible, the damages causing the alterations of ER functions. Recently, a link between ER stress and tumour growth and development has been proposed, with in particular, the high expression levels of the ER stress target proteins ATF-6 and XBP-1 correlated with the development of hepatocellular carcinoma (HCC). Based on the available literature and our current knowledge, we hypothesized that the activation of the UPR may represent a determining factor in HCC development. To test this hypothesis, we will at first characterize ER stress signalling networks in human primary hepatocytes and in cell lines derived from human HCC. These data will be analysed to identify potential ER stress signalling intermediates specific for HCC.The selected targets will be validated for their involvement in ER stress signalling using an over-expression or silencing approach in HCC derived cell lines. These targets will be validated in human tumour biopsies in conjunction with the assessment of the activation of ER stress signalling pathways. Integration of these data with the information available for each tumour will then allow for the establishment of specific tumour signatures. Finally, this approach will also lead to the validation in situ of the ER stress targets identified previously, thus iden
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Integrated Weather, Sea Ice and OCean service system'.

assistant: **Objectives**

The IWICOS project aims to increase the safety and cost-effectiveness of fisheries, sea transport and exploitation of marine resources in Northern European waters. The project will develop a marine information system, which will provide a single-entry access to meteorological, sea ice and oceanographic (met-ice-ocean) data and products. The system will be based on data provided by weather forecasting, ice and research centres.Objectives:The objective of IWICOS is to develop a prototype marine information system which will provide a single-entry access to meteorological, sea ice and oceanographic (met-ice-ocean) data and products.The prototype will include an end user system which allows users to select, order and retrieve products offered by the consortium and to pay electronically. Innovative met-ice-ocean products will be developed which combine satellite, weather, ice and ocean data and are suitable for transmission via the Internet or other communication channels.Work description:The IWICOS prototype will be designed with specifications of functionalities based on requirements from users of met-ice-ocean data, including those working at sea. A set of meta-ice-ocean products, which are suitable for electronic transmission, will be developed and adapted to various regional requirements.A PC based end user system will be built to retrieve and display met-ice-ocean products in a user-friendly way. The system will use Internet and other networks in combination with Inmarsat and cellular telephone, allowing IWICOS to function in coastal and sea areas.A product retrieval and management system is to be developed and used by each service provider of the consortium to handle ordering and distribution of products to a number of users, including payment/invoicing.Practical demo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Audiovisual systems and home platforms specific support action' to be submitted under Sixth Framework.

assistant: **Abstract**

Networked audiovisual systems and home platforms" is one of the strategic objectives under the FP6 IST work programme, because of its unique value for the global competitiveness of European industry and for the development of a common market. AVISTA project, structured as an SSA, aims at supporting the implementation of FP6 in this area, helping the preparation of future work program policies, generating shared knowledge, disseminating achievements, and promoting tools to facilitate the participation of a broad scope of organisations. In particular it will design and implement the Concentration Plan, Standardization Plan and Communication Plan in Networked Audiovisual Systems and Home Platform Area.AVISTA will contribute for a successful implementation of the work programme: appropriate coverage of technologies, assistance to the Commission on any recovery measured to be adopted to amend technological gaps and, ultimately, a bigger and higher value of the overall European research in this field. A special effort will be done to consider particularities of new FP6 instruments, networks of excellence (NoE) and integrated projects (IP).AVISTA partners, with both personal and professional reputation in this field, thus have a high potential that their recommendations will be accepted and adopted at individual FP6 project level, thus significantly contributing to strength and empower the overall strategic objective 2.3.1.8., by bringing additional pieces of consistency on the resources dedicated to research and innovation in this field, as well as providing a high level competence guidance to assist projects to achieve their pursued goals. Furthermore, the New Media Council will act as a permanent consulting body to both the Commission and to the rest of the task of the AVIS
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Development of a high throughput genomics-based test for assessing genotoxic and carcinogenic properties of chemical compounds in vitro'.

assistant: **Concept**

The major aim of CARCINOGENOMICS is to develop in vitro methods for assessing the carcinogenic potential of compounds, as an alternative to current rodent bioassays for genotoxicity and carcinogenicity. The major goal is to develop a battery of mechanism-based in vitro tests accounting for various modes of carcinogenic action. These tests will be designed to cover major target organs for carcinogenic action e.g. the liver, the lung, and the kidney. The novel assays will be based on the application of omics" technologies (i.e. genome-wide transcriptomics as well as metabonomics) to robust in vitro systems (rat/human), thereby also exploring stem cell technology, to generate "omic" responses from a well-defined set of model compounds causing genotoxicity and carcinogenicity. Phenotypic markers for genotoxic and carcinogenic events will be assessed for the purpose of anchoring gene expression modulations, metabolic profiles and mechanism pathways.Through extensive biostatistics, literature mining, and analysis of molecular-expression datasets, differential genetic pathways will be identified capable of predicting mechanisms of chemical carcinogenesis in vivo. Furthermore, generated transcriptomic and metabonomic data will be integrated into a holistic understanding of systems biology, and applied to build an iterative in silico model of chemical carcinogenesis. Subsequently, predictive gene expression profiles, typically consisting of some 150-250 genes, will be loaded onto high throughput dedicated DNA-chips, thus accelerating the analysis of transcriptomic responses by a factor of 100. It is expected that the outcome of this project will generate a platform enabling the investigation of large numbers of compounds for their genotoxic and carcinogenic potential, as envisag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Renewable Energy and Connectivity Hub' (REACH), addressing dissemination and exploitation.

assistant: **Impact**

Being a world leader in e-learning, e-banking and remote healthcare, EU companies are yet struggle to access the potential market of 1.4 billion off-grid people in developing regions. Off-grid communities in these regions rely on mobile phones for communication and to access essential services such as money transfer, healthcare. Without viable renewable alternatives, off-grid power in developing regions is currently provided through highly unsustainable fossil fuelled methods, and internet connectivity is exceptionally limited. This creates a significant business opportunity for providing reliable, clean and affordable charging for mobile phones and internet access. BuffaloGrid has developed a unique solar power based Hub system and a patent-pending remote payment control mechanism by which mobile phones (or other devices) can be charged under the control of a central server to ensure accountability, transparency and market insights. By combining renewable power and internet connectivity, BuffaloGrid enables EU companies to deliver essential internet-based services (e.g., e-health, e-education, e-governance etc) in developing regions. BuffaloGrid supplies Hubs free to local agents, offering them opportunities to provide mobile charging and internet access to their local communities. This will stimulate local enterprise, encourage entrepreneurship and boost economic development. BuffaloGrid’s unique model of providing the Hub for free, and unlocking access to power, allows demand to be met without charging high fees. Powered by solar energy, BuffaloGrid Hubs are emission-free during use and BuffaloGrid will take back Hubs for upgrade/ remanufacture/recycling at EoL (End-of-Life). During this project BuffaloGrid will develop a detail design of cost-optimised, mass-produci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transgenic analysis of the role of tumour necrosis factor - tnf - in immune function', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Disregulated production of TNF is implicated in many diseases such as arthritis and multiple sclerosis. Evidence is emerging that TNF acts via different mechanisms depending on whether the transmembrane or soluble molecular form is the activating molecule. Previously a transmembrane TNF model has been developed, but no corresponding soluble TNF model is available. It is therefore proposed to create such transgenic animals and to use them to assess the individual contribution of each form of TNF in immune functioning. It is also proposed to create TNF mutant mice where either soluble or trasmembrane TNF is expressed in the absence of endogenous TSF. It is also proposed to create targeted mutants where expression is directed to either the T cell or macrophage cells using previously defined cell specific modifiers of expression such as the CD2 LCR known to target T cell specific expression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Farming Transitions:  Pathways Towards Regional Sustainability of Agriculture in Europe' (FARMPATH).

assistant: **Concept**

In FarmPath, we propose that increasing sustainability in agriculture is best addressed by enabling flexible combinations of farming models, which vary to reflect the specific opportunity sets embedded in regional culture, agricultural capability, diversification potential, ecology, and historic ownership and governance structures.  We will enable progress towards this goal of increased regional sustainability of agriculture through a transdisciplinary research approach, where knowledge is co-produced by scientists, stakeholders and practitioners. FarmPath will specifically integrate theoretical and conceptual approaches to transition and transition management with recent research on adaptive capacity and resilience in farming systems, food regimes, and farm level transitions to multifunctionality, and build on previous EC funded research projects on sustainability and innovation in farming systems, and production and consumption chains.  FarmPath will assess a set of farm and regional level sustainability initiatives to identify conflict and complementarity, focusing on how combinations of initiatives, actors, technologies and policies can achieve synergies which initiate transition pathways at regional level.  FarmPath will engage in participatory visioning and scenario assessment in contrasting national and European regions, to identify transition pathways: combinations of visions and the social and technical mechanisms and innovations needed to reach these visions. This will lead to the development of a handbook for assessing and identifying actions which can be taken by policy makers to facilitate transition towards regionally sustainable agriculture.  FarmPath will also investigate issues surrounding young people and new entrants to farming in specific relation to