RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Engaged Universals: Ethnographic explorations of  ‘Universal Health Coverage’ and the public good in Africa' (2014-2020).

assistant: **Concept**

UNIVERSAL HEALTH is an anthropological study that follows how a new global policy, Universal Health Coverage (UHC), travels and is engaged by policy-makers, bureaucrats and citizens in three African countries. Defined by the WHO as ensuring that all people can use the health services they need without financial hardship, UHC is a powerful concept that approaches public health as a matter of justice and obligation and is included in the Sustainable Development Goals. UHC is particularly important in Africa, where structural-adjustment policies undermined state capacity, promoted privatization and pushed the burden of payment onto the poor. Recent global health initiatives have done little to address the neglect of national health-care systems and citizens’ lack of trust in them. In these contexts UHC is interesting because it reinserts questions of state responsibility and the public good into health-care. Historically however, African states have only partially pursued the public good, while in practice UHC is surrounding by conflicting interests. UHC is thus not a universal model but a contested field, making it an intriguing site for anthropological research. With a focus on actors and institutions at global, national and local levels in each country, the project will explore how moves towards UHC engage relations between states and citizens and universal concepts such as the public good; how UHC intersects with formal systems of social protection; and how it influences informal social networks that support health, thus situating UHC in national histories and social practices. Tracking the frictions surrounding UHC at the levels of policy-making, implementation, among beneficiaries, and in public debate, the project will use ethnographic methodology in innovative ways
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Time-domain Gibbs sampling: From bits to inflationary gravitational waves' (Bits2Cosmology).

assistant: **Concept**

The detection of primordial gravity waves created during the Big Bang ranks among the greatest potential intellectual achievements in modern science. During the last few decades, the instrumental progress necessary to achieve this has been nothing short of breathtaking, and we today are able to measure the microwave sky with better than one-in-a-million precision. However, from the latest ultra-sensitive experiments such as BICEP2 and Planck, it is clear that instrumental sensitivity alone will not be sufficient to make a robust detection of gravitational waves. Contamination in the form of astrophysical radiation from the Milky Way, for instance thermal dust and synchrotron radiation, obscures the cosmological signal by orders of magnitude. Even more critically, though, are second-order interactions between this radiation and the instrument characterization itself that lead to a highly non-linear and complicated problem.I propose a ground-breaking solution to this problem that allows for joint estimation of cosmological parameters, astrophysical components, and instrument specifications. The engine of this method is called Gibbs sampling, which I have already applied extremely successfully to basic CMB component separation. The new and ciritical step is to apply this method to raw time-ordered observations observed directly by the instrument, as opposed to pre-processed frequency maps. While representing a ~100-fold increase in input data volume, this step is unavoidable in order to break through the current foreground-induced systematics floor. I will apply this method to the best currently available and future data sets (WMAP, Planck, SPIDER and LiteBIRD), and thereby derive the world's tightest constraint on the amplitude of inflationary gravitational waves. Additio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Detecting weak selection in eukaryotic genomes: effects of recombination rate' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

One of the challenging tasks given by the arrival of a complete genome is the detection of the genomic regions undergoing weak selection. This can only be done by comparative sequence analysis using bioinformatics tools to recover, store and analyze genomic data. According to population genetics models, the efficacy of natural selection is expected to vary with the recombination rate. The study of the impact of the recombination rate variations on the evolution of DNA sequences is thus required to detect regions undergoing weak selection. However, as we showed during my PhD, recombination has other neutral (= non selective) effects that could interfere with its role on selection efficacy. I propose to reevaluate the existent models of the recombination effects on genome evolution by taking into account these neutral effects. The modified models will then be tested with available genomic data from Drosophila melanogaster, Caenorhabditis elegans and Arabidopsis thaliana. This project involves bioinformatics, statistics and modeling approaches aimed at integrating and quantifying the effects of recombination on genome evolution. The scientific environment of the Charles worth's group is particularly adapted to this goal because they have a strong interest and experience on these topics. This will allow me to get population genetics skills in order to complement the genomic data analysis skills that I acquired during my PhD. For the host group, this will be the opportunity to get bioinformatics tools coming from the French group where I did my PhD. This will also allow fruitful scientific exchanges since applicant and host have different views about the effects of recombination on genome evolution.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Nanofluidic chips for reproducible cryo-EM sample preparation with picoliter sample volumes' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Cryogenic transmission electron microscopy (cryo-EM) is a technique for high-resolution imaging of radiation-sensitive biological macromolecules under near-native conditions. Cryo-EM sample preparation techniques rely on rapid cooling of an aqueous suspension of biological macromolecules to obtain a thin layer of amorphous ice containing the solute. Problems associated with current implementations are considered a major bottleneck to realizing the full potential of cryo-EM: excessive sample consumption, the difficulty to reproducibly obtain ice conditions suitable for high-resolution imaging and the extensive contact of solute molecules with a large air-water interface result in only a small fraction of the imaged molecules contributing useful information for the final 3D reconstruction. Poor time resolution of these methods furthermore precludes the visualization of dynamic structural changes that provide critical biological insight. In our laboratory we have developed technology to design nanofluidic MEMS devices suitable for cryo-EM imaging. We here propose to explore product development of a nanofluidic chip for reproducible sample preparation with picoliter volumes. The sample is contained in nanochannels formed between membranes of an electron-transparent material, thereby controlling ice thickness and avoiding formation of an air-water-interface. This method has all features to push cryo-EM to new frontiers: it requires minute amounts of sample, robustly provides uniform and customizable thickness gradients across the sampling area at a time resolution that is limited only by the vitrification process itself. Our CryoChip will provide entirely new opportunities for time-resolved cryo-EM imaging and high-throughput applications in structure-based drug design for p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Window to the brain: a game changer in the discovery of human neuronal circuitry, cellular heterogenicity and biomarker profile indicative of early Alzheimer's disease -related pathology' (HUMANE).

assistant: **Concept**

The molecular mechanisms leading to Alzheimer's disease (AD) are poorly understood. This is due to lack of human tissue samples for research representing early changes of AD pathology. The accumulating pathology, including beta-amyloid and tau proteins, are manifested by concomitant neuroinflammatory reactions geared by malfunctional microglia. Microglia in the human and mouse AD brain exist in various subpopulations from which a specific, disease-associated microglia population is thought to be involved in AD pathogenesis. However, there is no evidence on whether and how these specific microglial subpopulations actually impair neuronal functions in human AD brain. I will now assess neuron-glia network activities and functions indicative of early AD pathology in humans. I hypothesize that early AD pathology selectively impairs neuronal circuits and that glial cells, especially specific microglia subpopulations, contribute to neuronal dysfunction and cognitive decline. These events contribute to a detectable vesicle-based biomarker profile in cerebrospinal fluid and blood prior the clinical disease. Due to early AD pathology present in a subpopulation of idiopathic normal pressure hydrocephalus (iNPH) patients, the brains of the iNPH patients offer a unique window to evaluate cellular and molecular events occurring during early AD. I combine a series of state-of-the art techniques to answer how and what glial cell subpopulations are associated with altered neuronal network activities at subcellular and spatial resolution in human brain impacted by early AD-related pathology. Novel methodologies established in my lab, knowhow and access to unique brain samples make me uniquely positioned to form a holistic view on how early AD-pathology impacts cellular functions at multi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Local Chemical AI: Achieving Transferability and Interpretability in Machine Learning Models through Quantum Theory of Atoms in Molecules.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Despite its remarkable accuracy, Machine Learning (ML) in chemistry faces significant challenges in transferability and interpretability, which limits its effectiveness in broader chemical contexts beyond the training data. I aim to overcome these limitations by leveraging Quantum Chemical Topology (QCT) for a physically rigorous atoms-in-molecules (AIM) fragmentation. This approach allows for the unbiased decomposition of molecular properties into local (atomic and interatomic) contributions. By integrating this precise partitioning with cutting-edge ML techniques, I seek to develop AI systems that not only predict molecular properties with high accuracy but also provide insights into underlying physical principles, resulting in more interpretable and generalizable predictions. The anticipated advancements are expected to benefit fields such as drug design, materials science, and the creation of transferable ML Force Fields (FFs) capable of accurately predicting the behavior of large and complex chemical systems. The project is structured around 4 main work packages (WPs), along with one devoted for data management, career development and dissemination. WP1 will focus on assembling a comprehensive and unbiased database of QCT-AIM properties within the CHONSFCl chemical space, serving as the foundation for model development. WP2 will employ advanced data analysis and pattern recognition techniques to explore relationships between local and global chemical properties, aiding in the refinement of predictive algorithms. WP3 will involve constructing and training predictive algorithms based on local QCT contributions, ensuring their physical accuracy and capability to extrapolate to new chemical contexts. Finally, WP4 will evaluate the applicability of these predictive tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Socially Distanced Solidarity: Far Right Recruitment and Enrolment During the COVID-19 Pandemic' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The questions at the centre of the project Socially Distanced Solidarity: Far Right Recruitment and Enrolment During the COVID-19 Pandemic (SODIS) are how far right organisations have adapted recruitment strategies in time of crisis, namely the Covid-19 pandemic, how successful these strategies have been, and how pathways to joining have shifted as a result of the pandemic. The Covid-19 pandemic provides an unprecedented opportunity to examine changes in collective action and political protest, providing a natural experiment for policy intended to tackle radicalism. Due to lockdowns and partial lockdowns across the world, organisations have had to cancel protest activities and other events at the centre of many recruitment strategies; the ongoing threat of Covid-19 well into 2021 means that organisations must alter their strategies. The subsequent change, or lack-there-of, in recruitment numbers can have implications for counter-radicalisation strategies moving forward. SODIS relies on a modern research design focusing on various perspectives of organisation recruiters and new organisation members, and different national contexts, while taking advantage of this exceptional time in history. A quantitative online survey will lend to a better understanding of motives and attitudes of organisations members in four national contexts and to gain a better understanding of motives for joining organisations, qualitative interviews will be conducted in each country. SODIS will elucidate drivers of far right mobilisation and pathways to radicalisation, contributing to scholarship on social movements, collective action, and radicalisation studies. It will provide insight for practitioners working on countering radicalism and recruitment into such organisations, engaging with the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Building a set-up for single molecule fluorescence detection; application to the study of multichromophoric systems with application in molecular photonics and electronics' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The aim of this project is to build an experimental set-up for single molecule fluorescence detection with the goal of studying multi-chromophoric systems with potential application in nanotechnology. Single molecule fluorescence spectroscopy (SMFS), a powe rful tool to address the behaviour of matter at the nanoscale, has nowadays evolved to a new frontier in science with high impact in a wide range of disciplines. One of the areas where SMFS has found a widespread application is in the investigation of multi-chromophoric assemblies, an issue of current interest due to the unique optical properties displayed by those systems, which are promising components for molecular photonic and electronic devices. Herein two types of artificially synthesised chromophoric assemblies will be studied. First, attention will be focused on model systems where excitation energy transfer takes place between coupled units of donors and acceptors. An enhancement of the energy flow efficiency is expected for those systems.This mechanism will be studied at the single molecule level and, subsequently, applied to build and investigate long dye arrays susceptible to allow for energy flow over large distances. To develop this project, the applicant has already reintegrated to a research institution in his own country with a contract for a period of five years. The experience of the host group with the synthesis of chromophoric systems will complement the applicant and apos;s expertise on the SMS field acquired during the initial Marie Curi e action in the University of Twente, then ensuring the successful development of the project.The applicant will acquire a fruitful training in nanoscience and nanotechnology during the reintegration period, two thematic priorities of the 6th Framework Programm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Relativistic Magnetic reconnetion in Atrophysical Plasmas' (ReMAP).

assistant: **Innovation**

Astrophysical compact objects like neutron stars and black holes are surrounded by a hot gas of charged particle known as plasma. In these environments, we observe powerful phenomena, including pulsar wind nebulae, jets, and gamma-ray bursts. The mechanisms behind particle acceleration and high-energy emissions, particularly magnetic reconnection, are not fully understood. Magnetic reconnection, where magnetic field lines break and reconnect, is believed to drive particle acceleration up to ultra-relativistic speeds, but its detailed dynamics remain largely unexplored.Recent advancements in simulation techniques and observational capabilities make this an opportune moment to resolve key questions in high-energy plasma physics. This project will investigate relativistic magnetic reconnection and its role in particle acceleration and radiation production using advanced simulation methods, including Particle-in-Cell (PIC) simulations for kinetic modeling. The ECsim code will explore the initiation of magnetic reconnection, while the TRISTAN-v2 code will incorporate photon interactions and pair production. Alongside these simulations, an analytical model will be developed to predict reconnection timescales and verify the simulation results. These tools will study the onset of reconnection, particle trajectories, and the effects of radiative cooling, providing new insights into high-energy astrophysical processes.


**Keywords:** plasma astrophysics, high-energy astrophysics, magnetic reconnection, plasma dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'In vitro replication of Pepino mosaic virusand characterization of replication essential host (tomato) factors' (PEP-REP-2) targeting Seventh Framework.

assistant: **Abstract**

Replication of positive-strand RNA viruses is a complicated process that involves the virus genome, virus proteins and host factors. In this system, an active replication complex is formed and the central role is played by the viral RNA dependent RNA polymerase. Pepino mosaic virus (PepMV) is a mechanically-transmitted plant virus member of the genus Potexvirus, currently under quarantine in Europe and with great potential of causing serious economical losses to tomato industry. This work extends a recently established bilateral (Greece-Spain) and takes advantage of great expertise of an incoming scientist from Egypt to: 1) purify PepMV membrane-bound replication complexes from infected tomato plants and try to convert them into a soluble, template dependent system for the analysis of viral RNA synthesis, and 2) identify tomato proteins that specifically bind PepMV-encoded proteins and PepMV RNAs (5'- and 3'-untranslated regions). We attempt to establish a model on PepMV to generate valuable data on virus replication with an emphasis on host protein factors. The analysis of viral replication complex components and the identification of the host factors and their role in viral replication constitute two key issues in virology and understanding the mechanisms of viral replication is essential for devising strategies to combat virus-induced diseases. We also intend to extend a research link between three Mediterranean laboratories (Greece, Spain and Egypt) with the view of growing broader and multidisciplinary in the future (e.g. private sector, governmental services, research groups, human capital) given the expansion of the virus and a recent agreement for the establishment of a Euro-Mediterranean Free Trade Area by the year 2010. The proposal capitalizes on the quality