RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Structural and functional analysis of mammalian sds22, a novel regulatory polypeptide of protein phosphatase 1' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

During my stay in Belgium from July 1993 onwards, I have been able to clone the mammalian homolog of SDS22, which was previously identified in Schizosaccharomyces pombe as a positive regulator of protein phosphatase-1. Our results have furthermore shown a high structural conservation of SDS22, a broad subcellular and tissue distribution, and a physical association with the catalytic subunit of protein phosphatase-l.  My future research in Rouen will mainly focus on the function and regulation of the phosphatase that contains SDS22 as a subunit. To this end, the latter phosphatase will be purified by affinity chromatography on SDS22 antibody-.Sepharose and its substrate speci- ficity will be studied. I will also investigate the potential role. Of phosphorylation of SDS22 by various protein kinases. Using recombinant SDS22, phosphorylation sites will be mapped and the interaction of SDS22 with the type-l catalytic subunit will be further analysed. Finally, the expected role of SDS22 in cell division and in the cell cycle will be investigated in fibroblasts and in Xenopus oocytes overexpressing SDS22.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'CRISPR/Cas9 based kidney disease modeling to elucidate novel genetic drivers and therapeutic targets in X. tropicalis'.

assistant: **Objectives**

CRISPR/Cas9 has untapped potential for disease modeling in the diploid amphibian model organism Xenopus tropicalis (X. tropicalis). Here, I propose to employ state-of-the-art CRISPR/Cas9 technologies (in vivo CRISPR Screening, ShCAST, CRISPR-NSID) to address  two current unmet clinical needs in congenital anomalies of the kidney and urinary tract (CAKUT). First, I will generate a novel animal model for autosomal dominant polycystic kidney disease (ADPKD) and investigate the role of a potential new druggable therapeutic target (ALDH1A1). Second, I propose to couple CRISPR screening methods to classical Xenopus animal cap differentiation assays to identify genes essential in the differentiation of pluripotent precursor cells towards pronephric structures. I intend to perform in vivo validation of hits to identify genes which underlie CAKUT development in X. tropicalis. Because a molecular diagnosis for CAKUT can currently only be made in about 20% of the clinical cases, the further elucidation of underlying genetic causes for CAKUT is of major clinical relevance. In vivo validated Xenopus CAKUT disease causing genes will be integrated with clinician networks (ERKNet, NEOCYST).  This interdisciplinary approach will use well-established techniques from developmental biology, state-of-the-art CRISPR/Cas9 approaches, light-sheet-microscopy and machine-learning based phenotyping protocols to model common genetic forms of kidney disease using the diploid vertebrate model X. tropicalis.


**Keywords:** CRISPR, Cas9, Xenopus tropicalis, Kidney disease modeling, CRISPR screen, Polycystic Kidney Disease, PDK1, ALDH1A1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biomarkers of disordered language in autism', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We know talk of ‘the autisms.’ Evidence shows us that autism refers to a heterogeneous group of neurodevelopmental disorders. This heterogeneity has greatly hindered our understanding of autism. This proposal will attempt to disentangle this heterogeneity by focusing on one piece of the autism phenotype: disordered language. More specifically, we will focus on impairments involving phonology, the sounds of language. Infants acquire phonological skills in the first year of life. A disruption in the development of these skills can compromise or even preclude language acquisition. Behavioral studies have provided evidence for an autism subgroup defined by phonological deficits. This subgroup is hypothesized to overlap with specific language impairment (SLI), a developmental language disorder clinically marked by phonological deficits. Given that the presence of speech before age five is the strongest predictor of a better outcome for a child with autism, understanding language deficits that can be present at a very early age is critical. This study will be the first to utilize EEG to examine neural activity relevant to phonological processing in children with autism with and without SLI as well as children with SLI. Our primary goal is to identify biomarkers indexing impaired phonology that can inform earlier diagnoses and treatments for children with disordered language. In addition to this goal, undertaking this research at the BCBL and the University of Seville, which will provide access to both mono- and bilingual children, will enable us to address a critical gap in both autism and SLI research. Developing bilinguals are the rule in the world. Despite this, little is known about bilingualism in autism or SLI. Scientific evidence suggests that there is a ‘bilingual adv
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Investigating the Role of the Unfolded Protein Response as a Novel Targetable Pathway in BRAF Mutant Colorectal Cancer' under Horizon 2020.

assistant: **Concept**

BRAF mutant (MT) colorectal cancer (CRC) accounts for 10-15% of CRC and represents the subgroup with the worst overall survival.  There is an urgent need to identify strategies that hit the 'Achilles Heel' in poor prognostic BRAFMT CRC. Preliminary data from the host lab have shown that BRAFMT CRC cells are vulnerable to disturbances in the Endoplasmic Reticulum (ER)-specific Unfolded Protein Response (UPR) machinery. The overall aim of the proposal is to identify whether the ER stress activator ONC201 in combination with MAPKi (MEK1/2i or BRAFi) will be a novel treatment strategy for BRAFMT CRC. Specific objectives of the proposal are1. Investigate the effect of ONC201 combined with MAPKi in BRAFMT CRC in vitro.2. Investigate the in vivo effect of ONC201 with MAPKi using BRAFMT CRC syngeneic and patient derived xenograft models.3. Assess prognostic/predictive role of ER stress proteins in CRC.UNBRACE will go beyond the current state-of-the-art by (i) developing a novel treatment strategy targeting the biology of poor prognostic BRAFMT CRC; (ii) using relevant pre-clinical models and clinical available datasets to underpin a novel stratified solution for BRAFMT CRC  with poor clinical outcome. UNBRACE adopts the concept “personalized medicine strategy” through applying a novel approach targeting  BRAFMT CRC. This fellowship will provide the researcher, through mobility, an increased set of excellent skills (e.g. molecular pathology; patient derived xenografts, 3D organoids), which will give him the opportunity to become a future leader in experimental cancer medicine.  The fellowship will result in a strong collaborative network between the host and partner institute, transfer of knowledge between academia and industry, ultimately resulting in a phase I clinical trial i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hyper-Realistic Models for Hands-On  Surgical Training  in Non-human Primate Biomedical Research' in the context of a Horizon Europe call.

assistant: **Objectives**

The PRISM project addresses critical challenges in neurosurgical training involving non-human primates (NHPs) within the framework of the 3Rs (Replacement, Reduction, Refinement) endorsed by the EU. NHPs are indispensable models in biomedical research, particularly in neurosciences, due to their close phylogenetic relationship with humans. However, invasive procedures on NHPs, including cranial surgeries and targeted ablations, pose ethical dilemmas and require highly skilled personnel. This project introduces a groundbreaking solution by developing the first hyper-realistic model for hands-on surgical training in NHPs. Collaborating with UpSurgeOn, experts in 3D simulation for human neurosurgery, PRISM aims to create a safe and ethical training environment for young researchers working with NHP. The project's objectives include the design of a hyper-realistic NHP model, the organization of pilot courses, and devising strategies for commercialization. PRISM promises enhanced visualization, tactile learning experiences, customizability, and ethical training, ultimately fostering career development, animal welfare, and research quality. Successful implementation will set a new standard in NHP neurosurgical education with global potential.


**Keywords:** 3R, non-human primates, cranial surgery, training
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Modular laser based additive manufacturing platform for large scale industrial applications'.

assistant: **Innovation**

MAESTRO aims to develop and combine with existing Selective Laser Melting (SLM) techniques five innovations that will constitute the basis of a highly competitive manufacturing value chain: (1) a single pre-process software for a numerical chain combining all mandatory steps and configurations of SLM together with its related pre- and post-processes, (2) Hybridization of SLM with MIM, (3) Adaptive process control of SLM, (4) system level integration of a modular platform, (5)  open access to an easy-to-use demonstration platform to reinforce to EU leadership in AM. These innovations will enable SLM to overcome the current limitations (speed, productivity, costs) to address large scale markets: productivity will be improved by 30%, cost reduced by 30% with quality towards zero defect. The performances of the MAESTRO platform will be assessed through a substantial number of demonstrators (7 in total: 4 brought by project partners, 3 selected through a EU-wide dissemination event). The MAESTRO consortium is composed of 10 complementary partners from 5 European countries. It is a well-balanced consortium with relevant expertise in SLM for tooling and aerospace applications (PEP), Materials and processes (CEA), Manufacturing technologies (UoB), Software Development (ALTAIR), MIM (OBE), SLM machine manufacturer (EOS). It is completed by 4 end-users from key sectors: Semiconductors and their packaging (III-V LAB), Automotive (CRF), Space (GEMMATE), Railway (ALSTOM).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Mechanisms and evolutionary significance of hyperploidy variations in a long-lived parasitic cancer'.

assistant: **Objectives**

Transmissible cancers are fascinating recently discovered biological entities. They have acquired the ability to cross host boundaries and spread between animals, even sometimes interspecifically, by the direct transfer of cancerous cells. In addition, despite asexual reproduction they have been shown to persist for hundreds or thousands of years in host populations. Importantly, in the absence of known sexual-like reproduction mechanism, transmissible cancers must cope with clonal degeneration. One challenging question that arises is to understand the evolutionary processes and molecular mechanisms by which genetic diversity can maintain in such a long-term clonal context. Several transmissible cancer lineages have been described in Bivalvia and they have all in common hyperploidy. Some distinct sub-lineages (with a common founder host) coexist in host populations with specific degrees of hyperploidy (2 to 10 times the host cell DNA content). Hence, the hypothesis that hyperploidization concurs to the persistence and long-term evolution of these transmissible cancers must be considered. HYPERCAN aims to decipher the evolutionary significance of hyperploidy and of its variation to amplify clonal heterogeneity in mussel transmissible cancers (MtrBTN). We will use a multi-disciplinary approach combining phenotyping and “multi-omics” in order to test evolutionary hypotheses. We will answer 3 main questions:1. Ploidy and fitness. Does a correlation exist between ploidy degrees and fitness?2.Evolutionary dynamics. How does evolution proceed in MtrBTN cancers?3.Hyperploidization mechanisms. How is hyperploidy generated and what is the fate of newly evolved hyperploid lineages?The project will have multiple outputs and applications among which to understand the genetic mechani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Combining innovation in vineyard management andgenetic diversity for a sustainable European viticulture' (INNOVINE) under Seventh Framework.

assistant: **Objectives**

The strategic goal of the project is to help the European vineyard sector facing the increasingly global competition by meeting:* Consumer demands for diversified high quality wines and concerns for food safety* Citizens’ requests for environment-friendly production systems involving decreased or no use of pesticides and spare of not renewable natural resources* Producers’ needs of plant material, tools and methods to help them cope with the negative impacts of climate change while responding to demands for quality, environmental friendliness and needs of profitabilityTo reach this overall goal, the project will:* At the plant level, improve and design agricultural practices (canopy management, irrigation, fertilisation, training systems, pest and disease control, etc.) aimed at maximising berry quality, durable resistance to pests and and diseases, and adaptation to climate change (higher CO2, drought, UV light, and higher temperatures)* At the vineyard level, design, develop and test innovative agronomic systems integrating new agricultural practices and taking into account the variability of constraints met by European vineyards grown under a wide range of environments* At the breeding level, diversify grapevine varieties with regard to desirable adaptative traits building on tools and knowledge developed through international breeding and genomic initiatives.The project will combine short, medium, and long-term approaches to respectively conceive innovative viticulture systems, design and test novel agronomic practices and decision support systems, and exploit the genetic diversity of grapevine that all together will ensure a progress towards sustainable viticulture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'AcceleRating the Translation of virtual twins towards a pErsonalised Management of fatty lIver patients' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The ARTEMIs project aims to consolidate existing computational mechanistic and machine-learning models at different scales to deliver ‘virtual twins’ embedded in a clinical decision support system (CDSS).  The CDSS will provide clinically meaningful information to clinicians, for a more personalised management of the whole spectrum of Metabolic Associated Fatty Liver Disease (MAFLD). MAFLD, with an estimated prevalence of about 25%, goes from an undetected sleeping disease, to inflammation (hepatitis), to fibrosis development (cirrhosis) and/or hepatocellular carcinoma (HCC), decompensated cirrhosis and HCC being the final stages of the disease. However, many MAFLD patients do not die from the liver disease itself, but from cardiovascular comorbidities or complications.The ARTEMIs will contribute to the earlier management of MAFLD patients, by prognosing the development of more advanced forms of the disease and cardiovascular comorbidities, promoting active surveillance of patients at risk. The system will predict the impact of novel drug treatments or procedures, or simply better life habits. The system will therefore not only serve as a clinical decision aid tool, but also as an educational tool for patients, to promote better nutritional and lifestyle behaviors.In more advanced forms of the disease, therapeutic interventions include TIPPS to manage portal hypertension, partial hepatectomy, partial or complete liver transplant. ARTEMIs will contribute to predict per- or post-intervention heart failure, building on existing microcirculation hemodynamics models.The model developers will benefit from a large distributed patient cohort and data exploration environment to identify patterns in data, draw new theories on the liver-heart metabolic axis and validate the perfor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'biogeniC gasEsous caRbon conversion into high added value chemicals and ingredients through a bio-based NETwork'.

assistant: **Objectives**

Europe emits approximately 506.7 million tonnes of biogenic CO2 annually, much of which is released into the atmosphere.  To harness this underutilized potential, it is essential to explore carbon capture and utilisation (CCU) pathways.CERNET aims to demonstrate the improved efficiency and sustainability of four Bio-Based Value Chains (BBVCs) that integrate four CCU systems using gaseous carbon sources (CO2 and CH₄) obtained from different industries, namely winery, waste management, and bioethanol production. These carbon sources, coupled with renewable energy will be used to produce six high-value chemicals and ingredients: L-alanine, protein hydrolysate, L-malic acid, sorbitol, PHA, and ectoine. The use of these products will be validated in the cleaning, cosmetics, packaging, and food industries.CERNET consortium comprises 21 partners from 10 EU countries, including underdeveloped bio-based sectors in Central and Eastern Europe. The team includes leading academia, technology developers, providers, and industrial partners from high biogenic carbon emitting sectors. Fourteen of the nineteen partners are Bio-based Industries Consortium (BIC) members, contributing significant self-funding and representing 26.2% of the project's in-kind contributions. CERNET aims to establish long-term strategies for adopting efficient CCU systems to convert biogenic gases, enhancing environmental performance over existing EU techniques. By producing chemicals and ingredients typically imported into the EU, the project aligns with the EU Industrial Strategy to bolster industry resilience and independence. Thanks to CERNET, up to 8.3 tonnes of gaseous carbon emissions will be abated in CERNET demonstrators. Replication and scalability will be driven by 16 Key Exploitable Results across te
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nutritional labelling software and claims: service, training and innovation offering to SMEs and industry in Europe' (NASCENT), addressing dissemination and exploitation.

assistant: **Impact**

From December 2016, the Food Information Regulations (EU 1169/2011; FIR) require all businesses selling pre-packed foods to include nutritional information on their labelling. This will have a dramatic effect on SMEs that, for the first time, will need to declare nutritional composition data for their products. Nutritional values can be obtained in several ways including direct analysis of the product, calculation using known nutritional data for the ingredients used, or calculation from generally established and accepted data. The aim of this proposal is to develop and extend a nutritional labelling software and claims service and training offering to SMEs and industry (including retailers) based on a pilot offering being developed in the UK/IE.  This is a direct exploitation of research activities and expertise of EuroFIR especially in terms of food composition data available via FoodEXplorer, algorithms and standardization of recipe calculation software and strong SME networks.  The extended service will provide an accredited nutritional labelling service for food producers using an existing developed software platform that will go beyond the automated services that are currently available on the market. Therefore the project is also expected to have a societal benefit to SMEs, which have limited resource and technical knowhow, and for whom the demands of complying with the changing legislation could be a tipping point for the ongoing success of their business. Also consumers will benefit from the provision of accurate, high quality nutritional information to help them choose more healthy foods. The funding is required to support the Innovation Associate, who work with 3rd Parties in IE, UK and IT to develop the procedures for the accreditation of the software system