RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Launching the next generation of mobile and multi-platform signature system based on biometric parameters' under Horizon 2020.

assistant: **Concept**

The SignSigma technology, developed by the SME Sigma Technologies, allows verifying the identity of a person from the dynamic parameters of their biometric signature with an extremely very low error ratio for first time merely using a common tablet or smartphone. The technology is not based on the image of the signature but on its dynamic biometric parameters (pressure, velocity, acceleration, etc.). This technology has been recognised as the best technology in the First International Signature Verification Competition.Smartphones, tablets and the growing access to mobility will accelerate identification needs, and ease  its introduction through various applications like banking, the health sector, insurance, digital preservation, control access, etc. The range of applications is huge, as this disruptive technology creates new markets as it will permit to be identified at anytime, and anywhere.We are almost done developing technology and we need the SME Instrument in order (i) to finalise the extensive trials we are undertaking on the different platforms (smartphones, tablets), (ii) to select and prioritize the most adequate application/s, (iii) to implement the final applications and integrate them with the specific enterprise content management systems, (iv) to undertake an intensive pilot tests of the product and the technology and (v) to assess the security of the whole system. In Phase 1, our specific objective is to prepare a clear Feasibility Study and Business Plan on how to reach and exploit this extraordinary technology properly in different scenarios, which might imply different business models, and different market strategies. It is expected that a new European directive will be issued authorizing and giving much more legal power to biometric signatures as i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Affordable, accessible and automatic screening solution for diabetic retinopathy' to be submitted under Horizon 2020.

assistant: **Abstract**

Diabetes is a growing global health concern, affecting 422M people today and the number is projected to rise to 642M by2040. Over 30 % of diabetics develop a vision-threatening complication called diabetic retinopathy (DR), which is the mostfrequent cause of preventable blindness in working-aged adults. DR is diagnosed from retinal images traditionally graded byan ophthalmologist. Regular eye screenings are the only effective way to detect disease at early stage to prevent visualimpairment or blindness. Hence, globally more than 1 billion screenings would be needed annually. Time, cost and resource efficient screening methods are needed to reach all diabetics.Finnish Optomed Oy (Ltd.) combines the precision of their handheld fundus camera with an automatic DR grading toestablish Smartscope-X solution. Smartscope-X consists of three main components: a low-cost handheld fundus camera, anautomated screening algorithm and cloud service for fundus images. With this unique combination, Optomed’s vision is tobring affordable, accessible and automatic DR screening available for all diabetics. In this project, the key ambition is tovalidate and commercialise Smartscope-X solution. The project has four objectives: (1) DR algorithm is integrated intoOptomed fundus camera and Optomed Cloud service is developed, (2) clinical validations are conducted, (3) piloting andcommercialisation of the Smartscope-X, with necessary approvals, (4) to establish a data safety and storage system.Smartscope-X will have a significant impact on visual impairment and blindness prevention in Europe and globally. Today,significant equipment investment and an experienced grader or ophthalmologist are needed. Hence, DR screeningavailability is limited. Smartscope-X user can be trained to use the solution i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Defining heterocellular signalling within the intratumoral stem cell niche of colorectal cancer' to be submitted under Horizon 2020.

assistant: **Abstract**

Purpose: Cells in a tumor are highly heterogeneous. The role and consequence of having multiple cell types within a cancer is mostly centered towards the function of cancer stem cells (CSCs) since they are the driving forces of tumor growth. However, the exact signaling cues that support CSC function remain to be understood. For instance, what are the roles of immediate descendant tumor cells in relation to CSC support? Do colorectal tumors make their own niche?Preliminary data: To study communication between different cell types (heterocellular signaling) in human colorectal cancers (CRCs), my lab developed movieSTAR technology to mark CSCs in patient-derived CRC organoids (PDOs) for high-resolution live imaging of their dynamics and behavior. Although niche factor dependency decreases along the adenoma-carcinoma transition, we identified a strong interdependency between CSCs and other tumor cells in colorectal PDOs of malignant nature. Hypothesis: We hypothesize a continuous existence of an intratumoral stem cell niche that remains essential for tumor growth and metastasis formation. Which types of heterocellular signaling support CSC function, especially at malignant stages, is unknown.Approach: This project aims to define heterocellular signaling between CSCs and intratumoral niche cells. Therefore, I) we will combine our expertise in human organoid technology for in-depth characterization of the nature of heterocellular communication within the intratumoral niche, II) high-resolution live imaging of PDOs to interrogate heterogeneity of signaling activities at cellular resolution and in real-time, as well as III) in vivo mouse models for validation and further studies of essential intratumoral signaling pathways.Innovation: Our integrative use of novel approaches wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovation Systems and European Integration' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The purpose of the Innovation Systems and European Integration (ISE) project is to elaborate a system of innovation approach in order to evaluate this new understanding of the development of science of technology and develop new policy options and implications. An important fact in understanding SIs is whether changes in SIs are moving towards European integration or towards increased fragmentation.This project will be carried out in nine sub-projects organised in three phases: - Review the policy implications of state of the art knowledge of systems of innovation. This concerns consolidating the state of the art knowledge of SIs in general, SIs relation to growth and employment, and SIs in relation to European integration. - Empirical research on five subjects: science-based technologies and interdisciplinarity, government technology procurement as technology policy, borrower-lender relationships in the financing of innovations, corporate governance and innovation performance, and cross-technological and sectoral entry patterns. - Synthesis and evaluation of the implications of SIs with particular focus on whether the national level remains valid or whether European level integration is by-passing previously national policy systems. The project's progress and deliverables will be organised around four work shops, two progress reports, and the final report. In addition several research articles are planned, and active exploitation of the results through the ETAN network is foreseen.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plant endomembrane trafficking in physiology and development' (PLANT-MEMB-TRAFF) under Seventh Framework.

assistant: **Objectives**

Understanding the structure and function of endomembrane compartments is central to a mechanistic understanding of eukaryotic cell behavior. Multi-cellular organisms show an increased complexity and specialization in their endomembrane trafficking pathways. Higher plants have independently developed multi-cellularity and show a differently structured, but highly complex endomembrane system that regulates numerous, fundamental processes, such as cell wall composition, plant nutrition or immune responses. However, the specificities of plant endomembrane trafficking are only insufficiently addressed by homology-based approaches, which are inherently biased and limited to modules and pathways that are conserved between animals/yeast and plants. I propose to address this by undertaking forward genetic approaches for regulators of endocytic trafficking in Arabidopis with newly developed tools. In addition, I will establish the root endodermis as a model to address the mechanism of epithelial polarity establishment in plants. Epithelia are a fundamental feature of multi-cellular organisms and have independently evolved in plants and animals. The root endodermis is a tissue of central importance for plant nutrition. It is accessible to analysis and displays all the defining features of an epithelium. Studying the endodermis will allow me to investigate how independent or conserved the mechanisms of epithelial polarity are. Apart from the immediate interest for a number of plant developmental and adaptive responses, I contend that both parts of my proposal are also of general, fundamental interest. Current comparisons between yeast and animals do not give us any reliable and coherent idea about what is truly fundamental or derived in eukaryotic membrane organization. Unbiased re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Optimised delivery systems for vaccines targeted to dendritic cells' under Sixth Framework.

assistant: **Concept**

In response to urgent medical and societal needs for novel immunotherapies for cancer and chronic infections and for prophylactic vaccination, optimised delivery systems for vaccine targeting to dendritic cells will be developed and clinically evaluated. The approach will rely on two new antigen delivery vectors, the detoxified adenylate cyclase toxoid (ACT) and the porcine parvovirus-like particles (PPV-VLP) which were recently shown to target dendritic cells very efficiently and specifically, allowing highly efficient presentation of delivered antigens to T cells. These vaccine vectors enable the induction of strong, specific and protective immune responses and have an established record of safety and efficacy in preclinical animal models. Under this project, academia experts in immunology, vaccinology, molecular biology and structural biology have joined forces with toxicologists, clinicians and vaccine production experts of two companies, in order to translate these novel vaccine technologies from research into clinical application. Based on the preclinical record of ACT-based vaccines in animal models, the leap into safety and efficacy Phase l/ll human clinical trial will be made with an ACT-based construct delivering the tyrosinase A.2 epitope as a therapeutic vaccine for metastasic melanoma.Simultaneously to GMP batch production, development and clinical testing, in-depth analysis of the cellular and molecular mechanisms and of the structural basis of ACT interaction with dendritic cells will be conducted, by placing particular emphasis on gaining new knowledge for further improvement of the delivery capacity of the ACT molecule towards enhanced efficiency and broader versatility in clinical use. The PPV-VLP vector will be developed in parallel by defining its ce
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Support to Future CROR and UHBR Propulsion System Maturation' (PropMat) targeting Horizon 2020.

assistant: **Abstract**

In the framework of the Large Passenger Aircraft ITD of Clean Sky 2, the industrial partners Airbus & Safran pushed the CROR low fuel burn propulsion concepts to TRL6, towards a flight test demonstration program. The activities proposed in this document will make a valuable contribution to this program. In addition PropMat provides valuable support to the implementation of the Airbus roadmaps for numerical methods for UHBR fan aeroacoustics, for UHBR aerodynamics, for experimental methods for aero-acoustics in Clean Sky 2, and for the SAAFIR UHBR Wind Tunnel test. The activities comprise: UHBR numerical aero-acoustic characterisation, UHBR Wind Tunnel experiment methods for SAAFIR (including fan design), and advanced UHBR wind tunnel test data analysis. In Clean Sky’s Smart Fixed Wing Aircraft, NLR supported Airbus & Safran with manufacturing the highly complex wind tunnel test rigs that laid the basis for the technical dossiers available today on CROR. Accurate numerical aero-acoustic simulations techniques were developed at NLR. In close collaboration with Airbus, these were subsequently applied to CROR which led to a deep physical understanding of this innovative propulsion concept. The current proposal builds on the success story of Clean Sky. It ensures a head start on pushing the frontiers of our current knowledge on novel CROR & UHBR propulsion concepts. In conclusion, NLR holds an impressive track record on engine integration support and is well equipped to carry out the proposed research.


**Keywords:** aircraft aero-acoustic characterisation, blade aero-elastic deformation, acoustic measurement techniques, acoustic chase aircraft flight testing, blade impact numerical simulation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nanotechnology based cochlear implant with gapless interface to auditory neurons', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Over 60 million of citizens in the EU suffer from hearing loss with its associated restrictions. In severe cases, hearing can only be restored by surgically implanting a neuroprosthesis called cochlear implant, which directly stimulates the auditory nerve.The bottleneck for optimal stimulation is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through (i) low frequency resolution, hence poor sound quality and (ii), strong signal amplification, hence high energy consumption responsible for significant battery costs and for impeding the development of fully implantable systems. Recent findings indicate that auditory nerve fibres can grow under neurotrophin stimulation towards the electrodes, which opens the door to address all issues simultaneously.NANOCI aims at developing a neuroprosthesis with a gapless interface to auditory nerve fibres. The neurites will be attracted and guided by an innovative, nanostructured gel matrix containing diffusible and surface-bound neurotrophic compounds towards the functionalized, neurotrophic electrode array surface. The long-lasting operation without interface degradation, reduced biofouling and improved conductivity will be achieved by nanostructuring the array surface using (i) various functional nanomaterials, including carbon nanotubes, combined with (ii) structuration methodologies such as ion implantation and sacrificial nanoparticle embedding in parylene, SOLID (solid on liquid deposition) encapsulation, and sonochemistry. Components will be validated using appropriate bioassays including human auditory neurons in vitro. In parallel, software models will be developed to exploit the bidirectional, gapless interface. Fusing all develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Angiogenesis Research to Improve Therapies for Vascular Malformations' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Congenital Vascular Malformations (CVM) are a group of diseases characterized by an inborn, localized defects of vascular morphogenesis. Occurring mainly on the face or other highly visible part of the body, the presence of CVM can cause emotional and social problems. Moreover, some malformations are painful or even life-endangering. Current treatments do not achieve optimal or long-lasting results. Thus, there is a pressing need for therapies that are more effective for these disfiguring lesions.  Currently, the cellular components of the CVM have not been isolated and analyzed, and there is no animal model for most CVM.  One attractive treatment strategy is to induce transdifferentiation of the endothelial cells (ECs) of the lesion. Transdifferentiation is the reprogramming of one specialized cell type into another, without reversion to pluripotent cells.The goal of my research is to isolate and characterize the EC, the major cellular component of the vascular malformations in order to develop targeted therapy for these lesions.  EC and pericytes will be isolated from CVM tissues. We will perform extensive mutational analysis and epigenetic profiling of these primary cells in order to identify any abnormalities in their developmental path. Also, using novel techniques derived from the stem cell field, I will aim at inducing transdifferentiation of the l EC by forced expression of transcription factor pools.My hypothesis is that reprogramming the EC lining the vasculature of the lesion to a mesenchymal phenotype will lead to obstruction of these vessels and cessation of blood flow, resulting in significant improvement.  Importantly, insights gained from this research will have wide implications for the vascular biology field. Thus, this project is novel and innovative.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Study and Identification of ADAM10 as Neuronal α-secretase in relation to Alzheimer’s disease' (ADAMNEURON).

assistant: **Innovation**

With life expectancy increasing rapidly in our Western world, Alzheimer’s disease (AD), a progressive neurodegenerative disorder resulting in dementia, is becoming more common, however no cures or effective treatments are currently available. The neurotoxic amyloid-β (Aβ) peptide appears central to AD pathogenesis, and is generated by β- and γ-cleavage of the larger amyloid precursor protein (APP). APP can also be cleaved by α-secretase, which cleaves within the Aβ peptide region and hence precludes the generation of Aβ. To date, the exact nature of α-secretase in the brain remains unknown, although ADAM10 (A Disintegrin And Metalloproteinase) seems to be the most likely candidate. This proposal is designed to determine definitively whether ADAM10 comprises indeed neuronal α-secretase activity in vivo, and to determine which factors regulate its activity. Using human APP (hAPP) transgenic mice deficient in neuronal ADAM10 expression we will determine whether levels of α-cleaved APP are down- and Aβ upregulated, whether this results in increased Aβ deposition and neurodegeneration, and whether ADAM10 is involved in learning and memory. Using neuronal cell culture we will determine whether growth and neuroprotective factors induce ADAM10 expression. In addition we will set up a screening system that will be used to identify molecules that regulate ADAM10 expression. These experiments will further our understanding of α-secretase in the brain and will aid in the development of novel therapies for AD.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Plural Reinforcement Learning' (PLURELEARN) targeting Seventh Framework.

assistant: **Abstract**

We propose a new paradigm for learning in complex high-dimensions dynamic environments. Our goal is to develop algorithms, theory, and applications that use plurality of learning approaches and models in a synergetic way. Our paradigm considers the task of learning a control policy by combining trial and error in the style of reinforcement learning with learning from a competent teacher whose interaction with the environment can be observed. Instead of using the teacher for imitation, our paradigm is focused on learning good representations of the world-model. We consider four specific issues in the new paradigm: (i) The usage of iteration and reiteration between learning from a teacher and reinforcement learning. (ii) Learning representation and structure from the teacher. (iii) Optimizing policies based on learned representations and reasoning about model uncertainty. (iv) Learning sub-strategies from a teacher and when and how to use them. We will develop algorithms and theory pertaining to the new paradigm and will apply it in two challenging domains: a fighter jet simulator and a network operating center simulator.