RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Site-Directed Covalent DNA-Encoded Library Selection for Targeted Protein Degradation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Targeted protein degradation (TPD) via the ubiquitin-proteasome system (UPS) has emerged as a powerful therapeutic strategy with the potential to tackle “undruggable” proteins by surpassing occupancy-driven inhibition. Degraders are mainly classified into molecular glue degraders (MGDs) and proteolysis-targeting chimeras (PROTACs). Despite the clinical success of MGDs such as thalidomide and the progress of over 50 degrader candidates into clinical trials, current approaches rely heavily on a small subset of E3 ligases, particularly VHL and CRBN. This leads to resistance and limits tissue specificity, underscoring the need to expand the E3 ligase repertoire and develop novel degraders. A key barrier is that PROTACable sites, where E3 ligases induce TPD, remain largely undefined, and scalable strategies for discovering new E3 ligase ligands are lacking. This proposal addresses these challenges by developing degraders from novel covalent E3 ligase ligands discovered through site-specific ligand incorporation-induced proximity (SLIP) combined with covalent DNA-encoded library (CoDEL) selection. The core of this approach is the use of activity-based protein profiling (ABPP) of hydroxy O-nucleophilic residues to guide SLIP validation, revealing new PROTACable sites on E3 ligases, followed by CoDEL selection to discover covalent ligands that engage these sites. The platform, SdCoDEL-TPD, will apply newly identified covalent ligands in PROTAC design and evaluate their efficacy for targets challenging to degrade through CRBN- or VHL- based PROTACs, such as EML4-ALK and the Bcr-AblT315I mutant. The potential of these covalent ligands to function as MGDs will also be explored. By mapping PROTACable sites and enabling the discovery of covalent ligands across previously inaccessibl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Immunogenic cell death (ICD) in the cancer-immune dialogue' to be submitted under Horizon Europe.

assistant: **Abstract**

The success of most if not all anticancer treatments depends on the (re)activation of immunosurveillance, as this has been documented for several therapeutic modalities, not only immunotherapy, but also chemotherapy, targeted therapy and radiotherapy. In response to antineoplastic drugs, malignant cells can undergo immunogenic cell death (ICD), thus exposing and releasing danger signals that act on pattern recognition receptors expressed by immune cells, in particular dendritic cells (DCs), to trigger the first steps of a therapeutically relevant anticancer immune response. Based on solid preliminary data and novel methodological approaches, we propose to obtain fundamental insights into the physicochemical properties and molecular mode of action of pharmacological ICD inducers (Objective 1), to create chemical-genetic systems for “synthetic” ICD induction for the study of ICD effects on the immune system without perturbation by pleiotropic anticancer drugs (Objective 2) and to identify new ICD-relevant immune checkpoints acting at the level of DCs (Objective 3). We will use this knowledge to generate an integrated view of the cancer-immune dialogue ignited, on one side, by malignant cells succumbing to ICD and, on the other side, DCs perceiving ICD, hence developing optimal strategies for the stimulation of tumor immunosurveillance (Objective 4). The concept of ICD has already been useful for patient-relevant biomarker discovery, drug development and trial design, strongly suggesting that a deeper exploration of this phenomenon will yield clinically relevant information.


**Keywords:** dendritic cells,  immunogenic cell death,  immunosurveillance
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'North Hungary and Koice Bilateral Regional Innovation Strategy Project' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

Strategic objectives: - foster regional and economic cohesion within and between the participating regions and improve their competitiveness by handling innovation as a key economic priority. Direct ~: - develop the absorption capacity of EU funds by impro ving the regional programming and implementing capabilities - strengthen transnational and regional co-operation in the field of R&D and innovation in order to open new areas of transnational activities and to exploit the existing capacities on a more efficient, integrated way - create an enabling environment for existing SMEs and innovative start-ups, spin-offs, investors and R&D centres by determining the most important stimulating and attractive factors - identify strategic key areas of innovatio n support activities and flagship projects - transfer experience and knowledge from the supporting partner region and connect to the EC networks and programmes, the European innovation bloodstream. North Hungary is one of the less-favoured regions of Hunga ry with outstanding R&D potencials but just in the change of its out-of-date industrial structures and infrastructure. It still has very strong economic, social and geographical links with the Koice region in Slovakia. The two regions are facing the s ame challenges in the field of competitiveness and innovation as well and have the intention to cooperate with the aim of accelerated economic development. This project represents a unique opportunity to test and implement the RIS process in a cross bord er environment, which if it succeeds, we are convinced it will, will greatly assist the construction of a European area of research&development where cross border linkages between SMEs and research structures are greatly facilitated. Partners from No rth Hungary, Koice, Cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'The strategic role of knowledge - intensive services for the transmission and application of technical and management innovation' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

This thematic network will bring together organisations from nine member states of the EU to undertake a collaborative exchange of understanding about the contribution of knowledge-intensive service consultancies to the commercial competitiveness and growth of client organizations in different sectors, types and sizes of firm, and core and peripheral regions. A series of interim reports, arising from each work package, will examine the application of this understanding to economic policy, especially as applied to the promotion of technical and organisational innovation.In targeting areas of policy, it will address: 1) The impact of the international integration of European service markets on the availability of consultancy expertise to clients in different parts of the Union. 2) The diversity of national experience, including the significance for consultancy activities of variable regulatory and corporate regimes, patterns of business organisation, including the corporate use of in-house expertise and the position of SMEs, and prevailing patterns of consultancy supply. 3) The degree and patterns of regional inequality in consultancy provision and use, their causes, and their significance for public agencies wishing to enhance regional technical and organizational innovation and competitiveness. The outcome of the thematic network will be a policy-orientated analysis of best practice in the employment of consultancy skills to support technical and organisational innovation, taking account of the needs of various sectors, large and small-medium enterprises, and the work of public agencies in different nations and regions. Where appropriate, proposals will also be made for further research into the changing corporate context of technological and managerial innovation invol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'RENEWABLE METHANOL-BASED SYNTHETIC MULTIFUEL PRODUCTION' in the context of a Horizon Europe call.

assistant: **Objectives**

The METHCESFUEL project pioneers next-generation synthetic renewable fuel technologies, contributing to Europe’s climate neutrality, energy security, and industrial resilience. By integrating carbon capture, green hydrogen, and thermochemical energy storage (TCES), the project enables the cost-effective production of drop-in fuels, including renewable methanol, synthetic methane, and dimethyl ether (DME). The project contributes to  replace fossil fuels in transport, power generation, and industrial applications, utilizing existing infrastructure and ensuring energy system stability. The project directly addresses the REPowerEU strategy by reducing dependency on Russian fossil fuels, diversifying Europe’s gas supply, and enhancing energy storage solutions. By leveraging renewable energy inputs such as solar, wind, and biomass-derived hydrogen, METHCESFUEL ensures carbon-neutral fuel production, effectively mitigating greenhouse gas (GHG) emissions. The project also strengthens Europe’s open strategic autonomy by driving cutting-edge digital process optimization, multi-scale system modelling, and advanced catalysis, increasing conversion efficiencies and economic viability. The innovation builds on a three-step conversion system: (1) Green methanol production from CO2 and hydrogen, (2) Methanol-to-syngas conversion, and (3) Syngas transformation into methane and DME, integrating high-temperature heat recovery to improve overall system efficiency. This TRL4 laboratory-scale demonstrator will validate feasibility, scalability, and sustainability, laying the foundation for industrial-scale deployment. By integrating renewable fuels with smart grids, carbon markets, and flexible energy systems, METHCESFUEL accelerates the EU’s green and digital transition. It reinforces Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Fish aggregating devices as instrumented observatories of pelagic ecosystems'.

assistant: **Objectives**

Tropical pelagic species are known to aggregate around floating objects. The objective of this project is to define specifications and develop prototypes of(1) autonomous buoys equipped with 360 sonars to observe aggregations, data loggers to detect individuals carrying electronic tags and satellite uplinks for both,(2) new electronic tags with ecological sensors.Also, a model of aggregation processes will be developed for interpreting data collected by currently available down-looking sonars mounted on buoys. Various field experiments will be conducted to assist in development of specifications for the autonomous sonars. The new-instrumented buoys will become observatories of pelagic ecosystems. They will reduce the dependence on research vessels and represent a major advance in fisheries research and the study of pelagic organisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Topological and functional modularity in biological regulatory networks' (2007-2013).

assistant: **Innovation**

Most functions and structures in living organisms seem to depend on subsets of elements organized as modules. In a modular system a certain process, performed by a module, does not depend heavily on the elements outside the module, and hence it is semi-autonomous. Modularity promotes evolvability, an organism’s capacity to generate heritable phenotypic variation, because it permits adjustment of a module without perturbing other functions and allows the combination of previously evolved functions. Understanding modularity is critical for the study of evolution and development of phenotypic traits.  As several biological regulatory systems can be represented as directed networks, it would be useful to study these representations of biological systems to search for network traits that could underlie modules, and to test under which evolutionary scenarios these traits may appear. Modularity in networks has been addressed by looking for densely connected groups of nodes with sparser connections between groups. This is appropriate for undirected networks, but with directed networks a dense connectivity in a group of nodes does not suffice for semi-autonomous behavior. Feedback loops and strongly connected components (SCC) might be related to the behavior expected for a module, and thus, be considered structural signatures of modules. If this is the case, we would find more of these structures in regulatory (modular) networks than expected by chance. The first objective of this project is to test if the perceived abundance of loops and SCCs in regulatory networks is statistically significant.  No study has addressed the appearance of loops and SCCs in directed networks and its relationship to modularity under realistic evolutionary scenarios. In this project several evolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Democratization of Solar Renewable Energy Adapted for the New Millennium' (DREAM).

assistant: **Concept**

Humanity still lacks a sustainable, large-scale energy economy. Efforts to transition toward such a system focus on electrification, renewable electricity, energy flow management, efficiency improvements, and behavioral changes. However, these measures fail to address the critical challenge of producing sustainable fuels and materials, which is also a centralized, undemocratic process, relying on production and distribution networks controlled by a few large players. While this suits fossil fuel economies with concentrated resources, a renewable energy economy—especially solar—offers broadly distributed resources and should imply a broader spread of fuel and material production. The project “Democratization of Renewable Energy Adapted for the New Millennium” (DREAM) will provide the tools and devices to enable a transition towards a renewable but also democratic and distributed energy economy. Focusing on solar fuels and materials processing, DREAM seeks to increase the process efficiency (i.e. utilizing significantly more of the solar spectrum) by integrating thermal synergies and (high-temperature) thermal transport in the field of photoelectrochemistry. We propose a high-temperature (>400 K) solid-state photoelectrochemical (PEC) device, avoiding wasting thermal energy, lowering overpotentials, and enabling the use of abundant materials. The synergistic combination of thermochemistry and photoelectrochemistry in a single device will allow for increased reaction rates and for running reactions that have so far not been successful in (photo)electrochemical mode only (e.g. nitrogen reduction). The integrated operation of such a high-temperature PEC device will reduce economic and energy costs, with the vision that each household, farmer, or local community can become a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Functional prognosis simulation of patient-specific spinal treatment for clinical use' in the context of a Seventh Framework call.

assistant: **Objectives**

Treatment and prognosis of spinal disc degeneration are still based on trial and error clinical decisions from the surgeon leading to numerous post treatment complications and eventual morbidity. A rational engineering approach based on advanced ICT and patient-specific predictive systems to treat various spinal pathologies needs to be developed to guide clinicians and improve long-term clinical outcomes. In silico virtual assessment of the evolution of treatments for patient-specific lumbar spine geometries, tissue properties, and loading histories is the cornerstone of such predictive system. Focus must be made on functional patient-specific models that have mechanobiological predictive capabilities. The objective of My SPINE is to adapt and integrate existing generic finite element (FE) models and use them as ICT tools in a clinical setting. The predictive system will consist in a set of specialized computing platforms. A geometrical and mechanical patient-specific model will be built, involving specialized processes such as image segmentation and analysis, mesh morphing, FE simulations, and optimizations. Based on the analysis of each integrated biomechanical and mechanobiological model, results will be evaluated in a probabilistic way, helping clinician to safely assess the risks and benefits of each simulated treatment. The main outputs of the project are the creation of a prototype computing platform with a graphical user interface for clinical settings and a patient-specific database of the lumbar spine. This interface will give clinicians the ability to virtually explore patient-specific treatment outcomes of disc degeneration, from short-term biomechanical ending to long-term mechanobiological tissue evolution. The project will impact ehealth by bringing new e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Physico-Chemistry of Carbonaceous Aerosol Pollution in Evolving Cities' in the context of a Horizon 2020 call.

assistant: **Objectives**

Carbonaceous aerosols (organic and black carbon) remain a major unresolved issue in atmospheric science, especially in urban centers, where they are one of the dominant aerosol constituents and among most toxic to human health. The challenge is twofold: first, our understanding of the sources, sinks and physico-chemical properties of the complex mixture of carbonaceous species is still incomplete; and second, the representation of urban heterogeneities in air quality models is inadequate as they are designed for regional applications. The CARB-City project proposes the development of an innovative modeling framework that will address both issues by combining molecular-level chemical constraints and city-scale modeling to achieve the following objectives: (WP1) to develop and apply new chemical parameterizations, constrained by an explicit chemical model, for carbonaceous aerosol formation from urban precursors, and (WP2) to examine whether urban heterogeneities in sources and mixing can enhance non-linearities in chemistry of carbonaceous compounds and modify their predicted composition. The new modeling framework will then be applied (WP3) to quantify the contribution of traditional and emerging urban aerosol precursor sources to chemistry and toxicity of carbonaceous aerosols; and (WP4) to assess the effectiveness of greener-city strategies in removing aerosol pollutants. This work will enhance fundamental scientific understanding as to how key physico-chemical processes control the lifecycle of carbonaceous aerosols in cities, and will improve the predictability of air quality models in terms of composition and toxicity of urban aerosols, and their sensitivity to changes in energy and land use that cities are currently experiencing. The modeling framework will have t