RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Directed Evolution of Metalloenzymes through Electrochemical Droplet Microarrays' (DEMED) targeting Horizon 2020.

assistant: **Abstract**

The goal of this Marie Curie Individual fellowship proposal is to establish directed evolution of redox enzymes by means of electrochemical microarrays (DEMED) to enable the direct screening of the enzyme properties desired for their application in electrochemical devices. An O2 reducing metalloenzyme for implementation in biocathodes of H2/O2 enzymatic fuel cells will serve as model system to demonstrate that directed evolution of such redox enzymes screened by electrochemical droplet microarray is advantageous to specifically improve biofuel cell performances. The selected metalloenzyme is rubredoxin: oxygen oxidoreductase (ROO), which has never been applied to H2/O2 enzymatic fuel cells so far. First, ROO gene will be cloned and its random mutagenesis library will be synthesized. Second, the electrochemical droplet microarray will be adapted to enable the screening of the desired properties of the metalloenzyme. Third, electrochemical directed evolution of ROO will be carried out. Finally, the interface of ROO and electrode based on redox active polymers will be co-evolved with ROO to achieve high electron transfer rates to the enzyme and thus enable the fabrication of a high performance biocathode. It is expected that this project will have a groundbreaking on directed evolution of metalloenzymes for their practical implementation in electrochemical devices.


**Keywords:** Directed evolution of enzymes, Biofuel cells, Oxygen reduction enzyme, Electrochemical microarray
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Growth in europe'.

assistant: **Objectives**

It is now clear to all economists that the rate of economic growth is the main determinant of welfare of a nation in the long run. Hence, perhaps the most important question economists can ask how do create the right (social, political and economic) environment to enhance the rate of economic progress.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'COntributing to Building of Awareness, Learning and Transfer of knowledge on sustainable use of raw materials' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The COBALT project will contribute to addressing several key challenges on the route towards more sustainable use of raw materials and resource efficiency. It will focus particularly on extraction, substitution, replacement and recycling of critical and scarce raw materials as well as raw materials with high environmental and social impacts. Through exchange and dialogue, COBALT will contribute to dealing with relevant raw-material related challenges and raising societal awareness on raw materials. Furthermore, it will identify research needs, build research partnerships and networks, and disseminate research results. Thus it will contribute to the implementation of the objectives of the EIP on Raw Materials.The challenges addressed by COBALT are linked to the dispositions of various societal stakeholders and therefore developing networks is a strong component of the project. First, the project will mobilise public awareness on raw material issues and promote raw material substitution, replacement and recycling through two multi-stakeholder European conferences as well as an internet platform designed for networking and sharing of views, research results and other knowledge. Second, the project will facilitate European and regional dialogues on raw materials between civil society and industry in order to ensure mutual learning, awareness and partnership building and an overall improvement in the framework conditions for sustainable use of raw materials and resource efficiency. Third, the project will identify shortages of skills that would enable more sustainable use of raw materials and develop strategies for addressing these shortages utilising multiplication effects for three groups of stakeholders: industry, primarily SMEs; polytechnic and higher education; and nati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Political violence in comparative perspective: A system dynamics approach to violent conflicts', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

As a general objective, this project aims to the development of a theoretical framework to analyze and model, from the perspective of System Dynamics and its relation to Peace Studies, situations and conditions of intractability related to both political violence and deep-rooted violent conflicts. It intends to undertake a comparative study using two cases that involve political violence and violent conflict. Such a comparison will address that their internal dynamics of intractability pose to governance an d integration. The cases considered will be the Spanish Basque Country political violence (seen at times and by some as a sometimes overt, sometimes minor conflict), and the protracted, political violent conflict in Colombia. The understanding of violent conflicts and political violence conflicts as parasite systems functioning within societies, will address the question of how systemic the treatment of long, eluding-resolution disputes may be of use to conflict policies, both at the national and international levels. This, through the development of behavioural models of (state and non-state) agents involved in processes of political violence (seen here as relational systems within national systems).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'AI-Inspect - an artificial intelligence tool for instant inspection of commercial properties' under Horizon 2020.

assistant: **Concept**

Tensorflight has created AI-Inspect, an artificial intelligence tool for the instant, remote and fully automated analysis of the different features of commercial buildings for the insurance and reinsurance sector.We develop the most advanced computer vision methods based on deep learning and are the first company that analyses not only satellite/aerial images but also street-level pictures. Due to the high scalability of our innovation, we are able to quickly provide information on large portfolios of commercial properties from any part of the world. We will cover a market niche where at the moment no one can provide a high-quality, rapid service and facilitate the credible risk assessment of properties such as retail and manufacturing sites, office and multifamily buildings, hospitals, schools, etc. AI-Insect will help insurance and reinsurance companies to reduce costs of on-site surveys and reduce losses caused by improper valuation. As a result, both the owners and the users of the properties will share lower costs of the insurance coverage.In a 5 years perspective, we estimate to analyse no less than 15.5 million queries at a cost of approx. 1 EUR each. Better insurance coverage in the real estate sector is extremely important bearing in mind the climate change. Accurate risk assessment is crucial for large insurance and reinsurance companies to step into more risky markets in the developing countries. The ultimate result is a globally shared risk of catastrophic events and higher stability of the economy in different regions of the world.In this feasibility study, we plan to perform a comprehensive market analysis that will refine the pricing strategy to fit regional specificity and identify new partners to conduct pilot testing on new markets. A technical assessm
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of Endocrine Disrupting Effects in Aquatic Organisms' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The aim of the present project is to develop cost-effective methodology for the assessment of ecotoxicological hazard arising from chronic exposure of aquatic organisms to sublethal concentrations of endocrine-disrupting chemicals or chemical mixtures. To achieve this objective, the project does not invent new assays or new endpoints, but it will identify what modifications of elements from existing tests on developmental or reproductive toxicity, combined with elements from existing in vitro screening assays or biomarkers of endocrine toxicity, could form a practical battery for prospective testing of the population-level effects of endocrine disruptors. Current ecotoxicological test methodology can not delineate the contribution of endocrine disruptors to observed adverse effects on development and reproduction of organisms. The present project goes significantly beyond that state-of-the-art - by investigating the predictability of endocrine-disrupting effects: The ability of inexpensive short-term assays and endpoints for predicting the lasting, chronic effects of endocrine-disrupting chemicals will be assessed by comparative evaluation of in vitro screening tests, suborganismic biomarkers, short-term in vivo tests, and multigeneration in vivo tests. - by investigating transgeneration effects of endocrine disruptors and different sensitivities of specific life stages: The project examines these questions that are of particular importance for the population level, by performing a series of life stage tests, chronic one generation tests and chronic multigeneration tests. - by investigating the extrapolation problem: The specifity of endocrine systems both in terms of function and species differences is critical with respect to the extrapolation of test results. The pro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Healthy Lifestyle in Europe by Nutrition in Adolescence' (HELENA) under Sixth Framework.

assistant: **Objectives**

The key to health promotion and disease prevention in the 21st century is to establish an environment that supports positive health behaviour and healthy lifestyle. In spite of scientific advance, non-communicable diseases are still the most common causes of morbidity and mortality in Europe. Most of these diseases have their origin during childhood and adolescence, but the relationship between the development of non-communicable diseases and the adolescence process is poorly understood. The interactions between the environment, the genetic predisposition and growth in children and adolescents have not been studied yet. Adolescence is a crucial period in life and implies multiple physiological and psychological changes that affect nutritional needs and habits. Many healthy (or unhealthy) life-long habits begin in adolescence. The HELENA proposal includes cross-sectional, crossover and pilot community intervention multi-centre studies, as an integrated approach to the above-mentioned problem. The following aspects will be studied: (1) dietary intake, nutrition knowledge and eating attitudes; (2) food choices and preferences (3) body composition; (4) plasma lipids and metabolic profile; (5) vitamin status; (6) immune function related to nutritional status; (7) physical activity and fitness; and (8) genotype (to analyse gene-nutrient and gene-environment interactions). The requeriments for health promoting foods will also be identified, and several sensory acceptable products for adolescents will be developed. Both scientific and technological objectives should result in reliable and comparable data of a representative sample of European adolescents. This will tribute to understand why health-related messages are not being as effective as expected in the adolescent populat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A novel design and production approach for comfort furniture for healthy senior citizens' (1998-2002) under Fifth Framework.

assistant: **Objectives**

Up till now there is no substantial product offer for the large market for furniture with more com-fort and functionality, with a modern look, aimed at the normal (senior) citizens, for a reasonable price. Causes are: lack of knowledge at the manufacturers of home furniture about the needs of the senior users; a design process not incorporating the needs of end-users; manufacturers that are small, having only limited skills and no R&D means. The proposers want to change this situation. They want to develop:- Design guidelines based on the properties and need of the elderly population- A new design methodology, incorporating the mentioned design guidelines- 2 Lines of comfortable configurable furniture, based on base element with additional modular elements- An ICT-linked design, production and central assembly chain to manufacture within 3 weeks after ordering, leading to a decrease in product price of 50%By this they want to set an example for the traditional industry and open up a whole new market, for senior citizens and others with comparable needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'towards virtual risk assessment for patient-specific stratification in Brugada syndrome' (Br-TRAP), addressing dissemination and exploitation.

assistant: **Impact**

The Br-TRAP project addresses the current gap in risk stratification for asymptomatic patients affected by Brugada Syndrome (BrS). BrS is an electrophysiological (EP) disease that manifests in a localized substrate in the right ventricular outflow tract of patients, generating a specific ECG pattern in V1-V2 leads. BrS is associated to sudden presentation of ventricular fibrillation (VF) in patients, to date risk stratification is based on risk scores and severely underperforms in asymptomatic cohorts due to lack of significant risk markers.Br-TRAP uses computational simulations of cardiac EP to define a patient specific virtual BrS substrate and use it to simulate the onset of arrhythmia and infer the conditions that precipitate VF in BrS patients. The substrate will be validated with experimental data and will be used to identify arrhythmic risk for each condition.Then, the virtual substrate will be embedded into an anatomically accurate torso and heart to calibrate the model using patient specific ECG. By establishing a relationship between surface leads and BrS substrate, risk stratification becomes patient specific and mechanistically driven.Br-TRAP will output two innovative results. First, the virtual substrate will be a software platform to generate virtual EP experiments that fosters standardization and reproducibility of computational results, while also lowering the degree of expertise needed to perform complex computational simulations. Second, the calibration methods used to tailor the virtual substrate to patient specific data will provide a innovative pipeline that  mechanistically link common clinical measures with information that can only be acquired invasively.Br-TRAP shifts risk stratification from a primarily statistical approach to a personalized o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Microglial activation in neurodegeneration in alzheimer's disease: a therapeutical target?' (MANAD).

assistant: **Concept**

Whereas, so far, most research on Alzheimer's disease (AD) has concentrated on neurons, this multidisciplinary European cooperation focuses on imbroglio cells. Activated imbroglio cells appear in large numbers at senile plaques and have the potential to kill contiguous neurons. Their uncontrolled intracerebral activation could explain neurodegeneration in AD. In this cooperation, the mechanisms of imbroglio relevance studied, and anti-inflammatory interventions with COX-2 inhibitors, anti-cytokine- and anti-CD14 receptor-directed treatments, interferon beta, azathioprine and strategies derived from the proposed experiments tested. These preclinical in vitro and in vivo experiments will identify anti-gill strategies that can be further studied in elderly persons with Alzheimer's disease as an important step towards the goal of ensuring healthy aging in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Taxonomic composition and cell size of marine eukaryotic phytoplankton', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The export of organic matter from the surface zone into the ocean interior is critically dependent on the specific phytoplankton taxa and their cell size. Thus, it is crucial to understand which factors select these ecological traits.Consistently with Mar galef's thesis, experimental works indicate that diatoms outcompete other eukaryotic phytoplankton when frequent, highly turbulent conditions are punctuated by short periods of water column stability. In contrast, dinoflagellates and coccolithophorids dominate in more stable environments characterised by low nutrient supplies.On the other hand, low nutrient concentrations are regarded as an important evolutionary force that select against large phytoplankton species in marine pelagic ecosystems. This probably accounts for the paucity of large phytoplankton in oligotrophic environments, whereas an increase in total phytoplankton biomass is commonly accompanied by an increase in the contribution of larger cells.On the background stated above, this proposal focuses on two main hypotheses:- nutrient composition and supply determine the taxonomic composition and size structure of the phytoplankton assemblages, and- large-scale patterns of phytoplankton distribution are governed by simple, physiological mechanisms operating at the individual level.To address these hypotheses:- we will conduct 'simple' competition experiments using three-taxa, two size and mixed culture assemblage, and- we will perform large-scale ecological analyses aimed at establishing overall patterns in the distribution of phytoplankton individuals and species in the sea.Recent work highlights the relevance of experimentally derived data to the analysis and understanding of large-scale ecological patterns. Ultimate, our purpose is to connect phytoplankto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Opening a new route in solid mechanics: Printed protective structures' (PURPOSE) targeting Horizon 2020.

assistant: **Abstract**

Dynamic fragmentation of metals is typically addressed within a statistical framework in which material and geometric flaws limit the energy absorption capacity of protective structures. This project is devised to challenge this idea and establish a new framework which incorporates a deterministic component within the fragmentation mechanisms. In order to check the correctness of this new theory, I will develop a comprehensive experimental, analytical and numerical methodology to address 4 canonical fragmentation problems which respond to distinct geometric and loading conditions which make easily identifiable from a mechanical standpoint. For each canonical problem, I will investigate traditionally-machined and 3D-printed specimens manufactured with 4 different engineering metals widely used in aerospace and civilian-security applications. The goal is to elucidate whether at sufficiently high strain rates there may be a transition in the fragmentation mechanisms from defects–controlled to inertia–controlled. If the new statistical-deterministic framework is proven to be valid, defects may not play the major role in the fragmentation at high strain rates. This would bring down the entry barriers that the 3D-printing technology has found in energy absorption applications, thus reducing production transportation and repairing, energetic and economic costs of protective structures without impairing their energy absorption capacity.It is anticipated that leading this cutting-edge research project will enable me to establish my own research team and help me to achieve career independence in the field of dynamic behaviour of ductile solids.


**Keywords:** Continuum Mechanics, Dynamic Fragmentation, Constitutive Modelling, 3D-Printing