RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of the igisol technique to allow the study of exotic nuclei beyond present-day limits' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The project's objective is to improve the Jyvaskyla IGISOL facility in numerous ways such that the combination with the wide range of beams delivered by the Jyvaskyla cyclotron and the availability of numerous detector systems, including a collinear laser facility, will make it a unique and very versatile tool for nuclear physics research. The proposed improvements are: ? development of a heavy-ion reaction ion guide, ? optimising nozzle shape, helium feeding and chamber geometry, ? making possible the use of very high intensity light ion beams, ? installing a sextupole ion transmission system, ? building a beam profile monitor sensitive to single ions. It is predicted that the intensities of neutron-rich medium-mass beams will reach levels allowing post-acceleration to high energy radioactive ion beams. Also, many presently unknown nuclei will become available for study.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Subaltern Privacy: Echoes of The Resistance in the Hispanic World'.

assistant: **Innovation**

During the early modern period, the Spanish monarchy treated its religious minorities mercilessly. From 1492 onwards, the Crown officially banned Judaism and Islam from its territory and offered their followers the possibility to convert to Catholicism and remain in the Iberian Peninsula. Many members of these communities accepted baptism, but a significant number of these new Christians limited their conversion to the official and public sphere. Privately, they continued to practice their pre-conversion beliefs, customs, and traditions. The high level of exposure in everyday life meant that many of them were exposed and suspicions of being false Christians spread throughout the kingdom. Society soon began to label converts as heretics and traitors, discriminating against them, and officially excluding them from public life based on their religious background and ethnicity. Faced with social stigma and the fear of being accused before the Inquisition, the descendants of these minorities began to eradicate all traces that identified them as converts—keeping their true identity and all links with their ancestors in the strictest secrecy. In this scenario of intolerance, hatred, and religious fanaticism, the project “Subaltern Privacy: Echoes of The Resistance in the Hispanic World” (SUBPRIVACY) will focus on the resistance practiced by subaltern groups in Spain (Jew converts, Moorish, crypto-Jews, and crypto-Muslims) against the assimilation, surveillance, and punishment policies of the Hispanic establishment. Its main objective will be to examine the resistance actions of these groups designed to preserve their ancient faith, culture, and collective memory underground, using the historical notions of privacy as an analytical lens.


**Keywords:** Historical Notions of Pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'STAT-TMDs: A statistical approach to TMD studies' (STAT-TMDs).

assistant: **Concept**

The description of the proton properties and its internal structure is still a challenging issue within Quantum Chromodynamics (QCD), the theory of strong interaction. The standard one-dimensional picture, encoded in collinear parton distribution functions (PDFs), is not able to explain the proton spin budget in terms of quark and gluon spin. A new class of parton distributions, including intrinsic transverse momentum effects, has then been introduced: the Transverse Momentum Dependent PDFs (TMDs). By encoding the correlation between the proton/parton spin and the parton intrinsic transverse momentum, they can provide a much richer and detailed picture: a 3D image of the proton. TMDs are now of great interest in hadron and spin physics, being able to describe several experimental observables at moderate and high energy. At the same time, they represent a perfect ground for testing fundamental properties of QCD, such as universality and factorisation.STAT-TMDs aims at building an improved statistical framework for studies of TMDs, applying for the first time modern statistical techniques to TMD analyses. Through a bottom-up approach, I will provide new and more robust phenomenological extractions of (un)polarised quark and gluon TMDs, carefully assessing the uncertainties in the data and extrapolation regions. This will eventually allow, thanks to global Bayesian reweighting techniques, for a quantitative estimate of factorisation breaking effects in inclusive polarised hadronic reactions.The project represents a timely effort, as it has the ambition to determine a new standard for the hadron physics community, and to set the ground for the future precision era of TMD studies, when data from the future US Electron-Ion Collider and fixed-target programs at the LHC will co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Women Translators in Italian Publishing' (WTIP), addressing dissemination and exploitation.

assistant: **Impact**

The project re-evaluates women’s participation in 1930s-1980s Italian intellectual discourse, through a special focus on the intersection of translation and publishing. More specifically, it will examine the professional activity of four key women, namely: the professional translators Maria Luisa (Nini) Castellani Agosti (1913-2005) and Adriana Motti (1924-2009); and two writers who devoted significant time to translations of foreign literature, Natalia Ginzburg (1916-1991), in her capacity as editor of the Einaudi Press, and Lalla Romano (1906-2001), as passionate reader of French and English literature. Starting from the assumption of a greater invisibility of women in translation and editorial tasks, the project aims at rediscovering these historical figures, by reinstating their place within the literary domain and the publishing panorama of Turin and Milan. Drawing on a interdisciplinary set of methodological tools and approaches, from historical analysis, sociology of literature, translation studies and archival research, the project will identify women’s covert roles and will quantify their impact in terms of number of translated projects undertaken, the width nature and scale of networks they were able to establish and the range of suggestions received and given to support the production of books. The study will consider published and unpublished items, translated outputs and the surrounding related writings, bringing a new focus on private correspondence as a vehicle for women to express their voices and advance views in a mainly male-dominated system. At the University of Milan, I will have the opportunity to achieve these objectives through a suite of well-designed training courses, which will support archival research and will enable me to apply advanced dig
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Mechanism of secretion of the bacteriocin enterocin p' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Enterocin P is a bacteriocin produced by Enterococcus faecium P13 and related strains. It has a potential as food biopreservative. In order to optimize the use of this bacteriocin in food preservation, it is important to study its synthesis and secretion. Enterocin P is synthesized as a 71 amino acid precursor (preEntP) with a typical N-terminal signal sequence of 21 amino acids long. The presence of this signal sequence suggests that preEntP is secreted through the General Secretion pathway (Sec-pathway) which would be unusual for two reasons :1) preEntP is a relatively small secreted protein, and2) many bacteriocins are secreted by dedicated ATP-dependent transport systems and use an atypical signal sequence. The main objective of this project is to establish the mechanism of preEntP secretion. The preEntP structural gene will be cloned, over expressed and purified from Escherichia coli, and alternatively, synthesized in an in vitro transcription/translation system. PreEntP will be used for in vitro processing and translocation assays employing inner membrane vesicles of E. coli, Ent. faecium and Bacillus subtilis. The dependence on the Sec- and YidC pathways and the identity of the processing enzyme will be determined. The results will be verified by in vivo studies of protein export.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Trust and security for next generation grids' in the context of a Sixth Framework call.

assistant: **Objectives**

The overall objective of the GridTrust project is to develop the technology to manage trust and security for the Next Generation Grids (NGG). We propose to have a vertical approach tackling issues of trust, security and privacy (TSP) from the requirement level down to the application, middleware and foundation levels. Our emphasis is on models and tools to assist in reasoning about trust and security properties along the NGG architecture.The main output of GridTrust is a framework consisting of:(1) a methodology and an interactive execution environment that will help Grid service requestors and providers to express and reason about trust, security and privacy properties for different kinds of VO topologies, taking into account aspects such as self-organisation, self-management, self-adaptation and evolvability;(2) a reference Grid Security Architecture, including an autonomic policy management for fine grained usage control of Grid resources; and(3) an open source reference implementation of trust and security management systems, validated by scenarios in the business domain.The resulting tools will be of a generic nature and will be validated on innovative applications from different application sectors. The tools will not be specific to the applications considered in the GridTrust project.GridTrust consortium involves a large industrial partner (HP European Innovation Center), end users (De Agostini), SMEs (Moviquity, Interplay) and European research groups covering the areas of requirement engineering, grid technology and security among others (CETIC, CCLRC, CNR, VUA). Moviquity , HP and Interplay are providing important test cases to validate the GridTrust framework, including innovative applications such as inter-enterprise knowledge management" and "distributed au
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Integration of heat treatment into machine-tools by using advanced grinding technology' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The manufacturing of steel hardened parts with high precision and life long performance for investment and capital good products represents an important key sector of the European industry. Conventional manufacturing steps for these kind of parts consist of premachining, heat treatment and precision machining on different facilities and locations. This procedure causes in the most cases inadequate logistic efforts, throughput time, and high energy consumption. Thus the goal of this project is to adapt advanced grinding technology to heat treatment and surface finishing in a single step operation. In the new process, named grind hardening, the heat treatment of unhardened materials will be performed by the dissipation of the grinding process energy. Starting points for the RTD work are based on elaborated theories, already performed basic experiments and partners knowledge. Finally, the availability of an integrated heat treatment technology based on surface hardening by the grinding process itself is envisaged. The main RTD working results will comprise the following achievements:  Concept and design of grind hardening machine tools.  Prototype machine tool demonstrators for small / large scale parts.  Spectrum of suitable precision tools and coolant media.  Sensor/data processing for on line/in situ monitoring and control.  Software package for simulation of heat dissipation in machining.  Neural network based methods for determination and correlation of machining and heat treatment parameters.  Software packages for prediction of grind hardening process behaviours. The consortium consist of SME machine tool manufacturers, precision tool and coolant suppliers. A strong-end user influence is provided by partners from the automotive supplier, transmission and hydraulic i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Mechanistic and Evolutive Development of Spine Biomechanical Modelling'.

assistant: **Innovation**

Lumbar spine finite element (FE) modelling can bring important information about load distributions in tissues involved in low back pain. However, current verifications of spine models cannot validate predictions at single tissue level (Noailly, 2007). Mechanistic models of spine tissues, respecting the link between composition, structure, and biophysical properties, can ensure accurate local predictions, but their use in complete segment models is still poorly developed. Thus, this project aims to mechanistically describe and validate the behaviour of a L3-L5 lumbar spine bi-segment FE model, by focussing on intervertebral disc collagen fibres and proteoglycans. Further mechano-biological developments of the model will be also initiated. In a first step, the lumbar intervertebral disc proteoglycan matrix will be modelled as an osmo-poroviscoelastic (OPVE) material. For the annulus fibrosus, proteoglycan matrix will be coupled to a previously developed fibre-reinforced composite model. The OPVE theory will be validated with a pre-existing lumbar disc FE geometry associated to a set of model-specific static and dynamic in vitro measurements. In a second step, the OPVE theory will be used to validate both the tissue and segment mechanics predicted by a previously developed L3-L5 lumbar spine bi-segment model. At tissue level, verifications will be done by correlating predicted intervertebral disc and vertebra load distributions with load-related tissue structures (Smit, 1997), compositions (Brickley-Parson, 1984), and cell phenotypes (Bruehlmann, 2002). Finally, a proteoglycan mechano-regulation theory will be developed, based on the influence of hydrostatic stresses and principal strains on the fixed charge densities described by the OPVE model. The new theory will be as
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Programming with Big Code' (AutoCode), addressing dissemination and exploitation.

assistant: **Impact**

Software synthesis aims to automate the creation of software by generating parts of software from a higher-level description. Until recently it was believed to be impossible to practically synthesize software beyond very small fragments. However, synthesis based on learning from existing large code-bases (“Big Code”) is making synthesis into a practical reality . The purpose of this PoC is to develop a platform that would lead to commercialization of our technology to improve programming productivity and code quality. We target two closely related applications: (1) Providing automatic assistance in programming tasks by learning from existing code, and (2) Providing on-line assessment of code quality as it is being developed using learned models. These applications have the potential to dramatically reduce time-to-market of new software, and improve its quality and security.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Deciphering the metabolic roles of the urea-cycle pathway in carcinogenesis for improving diagnosis and therapy' (UreaCa).

assistant: **Innovation**

Almost 100 years ago, Warburg described a metabolic change in energy flux that occurs during carcinogenesis. Since then, multiple studies have demonstrated how anabolic synthesis of macromolecules can be altered to support cancer cell progression. Yet, the potential effect of altered catabolic degradation of macromolecules on tumour carcinogenesis has been much less studied. The urea cycle (UC) is the main catabolic pathway by which mammals excrete waste nitrogen. Although the complete UC pathway is liver-specific, most tissues express different combinations of UC enzymes according to the cellular needs. Surprisingly, we find that changes in expression of UC components causing UC dysregulation, (UCD) is a global phenomenon in cancer, metabolically augmenting net nitrogen usage for the synthesis of macromolecules by reducing nitrogen waste. This metabolic alteration is associated with poor patient prognosis. Thus, we hypothesise that UCD provides a major metabolic advantage to multiple aspects of carcinogenesis and as such, leads to specific, identifiable genomic and biochemical signatures, with implications for cancer diagnosis and therapy. To pursue our hypothesis, we will incorporate state-of-the-art comparative genomic, peptidomic, metabolomic, and molecular approaches to explore this scientific “blind spot” of nitrogen metabolism in carcinogenesis. We will investigate how UCD causally affects carcinogenesis, by characterising tumour-specific functions of UC enzymes (Aim I), correlating tumour phenotypes with systemic biomarkers (Aim II), and testing the treatment efficacy of drug combinations targeting UCD in cancers (Aim III). Our proposal, strengthened by my training as a physician scientist, harbours considerable potential for translational diagnostic and therape
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel Strategies for the Modulation of Immunity to AAV vectors' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Adeno-associated virus (AAV) vectors are among the most efficient vectors for in vivo gene transfer. Experience in human gene transfer trials showed that targeting hepatocytes with AAV vectors has the potential to correct diseases like hemophilia, congenital blindness, and lipoprotein lipase deficiency. However, these studies also suggest that one of the last obstacles to be overcome in order to achieve long-term disease correction is the immune system. As a result of exposure to wild type AAV, a significant portion of the human population will develop both humoral and cellular immunity to the virus, which can greatly affect the safety and efficacy of gene transfer with recombinant AAV vectors. This proposal combines knowledge on immunology and AAV vector mediated gene transfer, with the ultimate goal of developing safe and effective gene therapy protocols. Studies in humans undergoing AAV gene transfer will help identify markers of T cell activation and correlate them with the outcome of gene transfer. Studies in humans receiving immunosuppressive (IS) regimens will help identifying drug regimens that could be safely used to modulate B and T cell immunity to AAV in the context of gene transfer. In the third aim of this proposal, IS regimens will be tested in vivo in the relevant animal models. Results from these studies will contribute to design safe and effective clinical gene transfer studies by providing new tools and markers for safety assessment and early intervention aimed at modulating detrimental immune responses directed against the AAV vector capsid. Furthermore, these studies address the issue of humoral immunity to AAV by identifying strategies to overcome the limitation of anti-AAV antibodies, thus allowing for treatment of a significant proportion of huma