RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'NUCLEOLAR-DEPENDENT SECRETION OF MICRORNA IN A MODEL OF DOXORUBICIN AND TRASTUZUMAB CARDIOMYOPATHY' (NUMIRDT), addressing dissemination and exploitation.

assistant: **Impact**

Combination of Doxorubicin (Dox) and the monoclonal antibody trastuzumab (Trz) is being effectively used against breast cancer, but associated with high incidence of cardiotoxicity. The mechanisms of Dox+Trz induced synergic cardiotoxicity are still unclear. Recently the activation of the microRNA 146a has been shown to have a role in the synergistic effect of Dox and Trz cardiotoxicity. MicroRNAs (miRNA) are ~22 nucleotides long non-coding RNAs regulating complex cellular processes. MiRNAs can be detected in the systemic circulation and their levels increase under various stress conditions. Growing body of evidence suggests that circulating miRNAs are actively released and may act as signaling molecules on close or even distant target cells. Mechanism of miRNA secretion is not completely characterized Recent literature suggests a intriguing idea that the nucleolus may play a critical role during miRNA release and reuptake . The short term goal of this proposal is to identify a diagnostic signature of circulating miRNA in response to Dox+Trz treatment. The long term goal is to study the mechanisms of release and reuptake of miRNAs and demonstrate the role of the nucleolus in these processes. Specific tasks will focus on: 1) Analysis of circulating miRNAs from plasma of mice treated with Saline, Dox or Dox+Trz. 2) Identification of secreted miRNAs in response to Dox, Trz , and Dox+Trz in adult human cardiac stromal cells (hCStCs) and cardiac progenitor cells (hCPCs). 3) Study the mechanism/s of release and uptake of miRNAs upon stress. 4) Role of the nucleolar protein nucleophosmin (NPM) on miRNAs export and uptake upon stress. Significance is the delineation of new mechanisms controlling myocardial stress response and identification of molecular interventional targets t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Interplay between influenza viruses and host SUMO pathways' under Seventh Framework.

assistant: **Concept**

Influenza viruses cause a significant seasonal disease burden and continually threaten to initiate human pandemics. Antivirals are available for treatment of influenza, however drug-resistant viruses often emerge. Thus, there is urgent need to develop new antivirals with lower chances of selecting resistance. As viruses rely extensively on cellular functions, one way to minimise resistance is to target new antivirals against host factors. This concept requires a fundamental understanding of mechanisms underpinning the interplay between influenza viruses and their hosts.In this project, we will investigate the role that host SUMO pathways play during influenza virus replication. SUMO proteins are important regulators of cell signalling, and are covalently linked to other proteins in order to alter structure, localization or function. As such, SUMO conjugation regulates many diverse aspects of biology. Our own work shows that global cellular SUMOylation increases during influenza virus infection, and that virus replication is severely impaired when cells are depleted of key enzymes and components required for general SUMO conjugation. Here, we will determine what viral components trigger SUMOylation, and which specific cellular enzymes are involved. We will characterize where in the cell SUMO conjugates accumulate, and for the first time apply large-scale affinity-based quantitative proteomics to the identification of proteins that become SUMO modified during infection. A key aim will be to correlate changes to the SUMO sub-proteome with the function of specific host SUMO-modifying enzymes, thereby establishing the mechanistic role of these modifications during virus replication.Understanding basic mechanisms underlying SUMOylation during influenza virus infection will pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'S=Smart U=Upgraded asset-values and quality of life P=Public Private Partnership E=Extended Energy Efficiency R=Renewables triggered by the project SH=Social Housing I=Investment N=Net Zero E=European' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The objectives and impacts of the SUPERSHINE project will assist and support the European Commission to implement the European Green Deal. Particular attention will be paid to the renovation of social housing, to help households who struggle to pay their energy bills. In addition, SUPERSHINE will also contribute to the decrease of energy poverty. The SUPERSHINE lighthouse districts will be characterised by energy efficient buildings, low carbon mobility, smart grids, efficient water and waste management, all underpinned by responsive technologies that optimise resources while promoting wellbeing and sustainable lifestyles. More specifically, SUPERSHINE will adopt an integrated strategy with these key principles: a)‘Energy efficiency first’; b) Affordability; c) Decarbonisation and integration of renewables; d) Life-cycle thinking and circularity; e) High health and environmental standards by promoting sustainable energy behaviours; f) Tackling the twin challenges of the green and digital transitions together; g) Respect for aesthetics and architectural quality. The main areas of intervention are: a) Strengthening information and incentives for public and private owners and tenants to undertake renovations while improving community participation or inspiring new patterns of citizen behaviour; b)Ensuring adequate and well-targeted funding by supporting innovative bottom up financial solutions such as Public Private Partnerships (PPPs) and Green Public Procurement (GPP) and collaborating with innovative local Small and Medium Enterprises (SMEs); c) Promoting comprehensive and integrated renovation interventions; d) Making the construction ecosystem fit to deliver sustainable renovation, based on circular solutions, use and reuse of sustainable materials, and the integratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of Direct Dehydrogenative Couplings mediated by Dioxygen'.

assistant: **Innovation**

The field of C-H bond activation has evolved at an exponential pace in the last 15 years. What appeals most in those novel synthetic techniques is clear: they bypass the pre-activation steps usually required in traditional cross-coupling chemistry by directly metalating C-H bonds. Many C-H bond functionalizations today however, rely on poorly atom and step efficient oxidants, leading to significant and costly chemical waste, thereby seriously undermining the overall sustainability of those methods. As restrictions in sustainability regulations will further increase, and the cost of certain chemical commodities will rise, atom efficiency in organic synthesis remains a top priority for research. The aim of 2O2ACTIVATION is to develop novel technologies utilizing O2 as sole terminal oxidant in order to allow useful, extremely sustainable, thermodynamically challenging, dehydrogenative C-N and C-O bond forming coupling reactions. However, the moderate reactivity of O2 towards many catalysts constitutes a major challenge. 2O2ACTIVATION will pioneer the design of new catalysts based on the ultra-simple propene motive, capable of direct activation of O2 for C-H activation based cross-couplings. The project is divided into 3 major lines: O2 activation using propene and its analogues (propenoids), 1) without metal or halide, 2) with hypervalent halide catalysis, 3) with metal catalyzed C-H activation. The philosophy of 2O2ACTIVATION is to focus C-H functionalization method development on the oxidative event.Consequently, 2O2ACTIVATION breakthroughs will dramatically shortcut synthetic routes through the use of inactivated, unprotected, and readily available building blocks; and thus should be easily scalable. This will lead to a strong decrease in the costs related to the produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Advanced Chemistry in Lean Low Emission combustor Simulations.' (ACHILLES) under Sixth Framework.

assistant: **Objectives**

The objective of the proposed Marie Curie Intra-European Fellowship is to provide the researcher with training and research experience in the field of combustion modelling and Large Eddy Simulations. He will be working in a multidisciplinary multilingual international research team and obtain the required training to work as a full member of the research team. The researcher has proven his academic capabilities through the excellent work, which he has achieved during this Ph.D. research. This Ph.D. research on the development of advanced combustion models has been performed in cooperation with industry (Rolls-Royce plc, UK). Building on this work, this proposal will give the researcher an opportunity to develop his career further, and exploit the technology developed during his Ph.D. research to the industry. Cooperation with universities and research institutes will be an essential part of the work, in order to keep up-to-date with the state of art. This will be enabled through existing collaborations with a considerable number of universities and research institutes of the host institute, via national and European research projects.The scientific objective of this proposal is to improve the modelling of Low Emission Combustors for aero-engines. During his Ph.D. research at the Eindhoven University of Technology the researcher has been working on the development and application of the Phase-Space Intrinsic Low Dimensional Manifold and Flamelet Generated Manifold method to as well premixed as non-premixed combustion processes. The innovative objective of this proposal is to introduce these methods in LES (Large Eddy Simulations) codes. These codes will subsequently be used to model Low Emission Combustors of aero-engines. The application of LES codes to model combustors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In-operando growth of organic mixed ionic-electronic conductors for brain-inspired electronics' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The development of advanced brain-computer interfaces, wearable and implantable bioelectronic devices, prosthetics, and soft robotics requires the ability to process signals in a highly individualized and localized manner. To achieve this, new materials and devices must be developed that can sense their surroundings, process information locally, and translate it into a format our body can interpret. Currently, (bio-)electronic devices rely on remote and energy-intensive cloud processing, but electronic devices that mimic the design of the human brain offer a solution. However, silicon-based devices have limitations such as rigidity, poor biocompatibility, and operating principles that differ from the ion signal modulation of biology. Organic mixed ionic-electronic conductors (OMIECs) have emerged as a promising option in the field of bioelectronics, as they are solution processable, potentially biocompatible, and can transport both electronic and ionic signals.The goal of INFER is to create next-generation intelligent bioelectronic devices using in-operando electropolymerization of OMIEC monomers. The proposed research activities aim to 1) understand how the molecular properties of OMIEC monomers impact their in-operando electropolymerization and the learning capabilities of the resulting biomimetic devices, 2) achieve biorealistic speeds, memory functionalities, and energy efficiencies without the use of auxiliary devices, and 3) prototype devices that can locally sense, process, and actuate/stimulate. The long-term goal is to create a brain-inspired intelligent bioelectronic platform that brings a new paradigm for in-sensor computing at the interface with biology.


**Keywords:** organic mixed ion-electron conductors, conjugated polymers, organic electronics, organic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Empowering New Venture Growth - RDNA', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

We are an Amsterdam-based startup with the ambition to help startups translate their ideas into successful businesses by using cutting-edge scientific knowledge, predictive analytics and industry best practices. RocketDNA is a modular software solution that empowers incubators to build a portfolio of fast-growing businesses through tracking, improving and predicting new venture performance. At the same time, it enables early-stage startups to grow in a professional and structured way while improving communication, knowledge exchange and transparency in the relationship with incubators. We employ a highly co-creative approach to product development, comprising frequent client interactions and close collaborations. Our goal is to use predictive analytics to integrate and evaluate various success factors that help better explain venture growth. We will use the feasibility study to develop two highly innovative features for our software that are part of our product strategy and enable us to scale up rapidly. These two solutions comprise a) the (automated) recommendation of concrete action to startups based on their idiosyncrasies and b) the prediction of scores, reflecting the overall likelihood of startup success.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Complex sperm collective motion under physiologically relevant conditions'.

assistant: **Objectives**

Collective motion of spermatozoa within the confined, viscoelastic milieu of the female reproductive tract is an underexplored determinant of fertilisation success. This MSCA project will uncover the physical rules that organise dense sperm suspensions into clusters, streams and turbulence-like flows, and test how environmental architecture and inter-ejaculate competition modulate these states. We will engineer physiologically inspired microfluidic landscapes with controlled curvature, viscosity/viscoelastic gradients and shear; record dynamics via phase-contrast and dual-colour fluorescence at high spatiotemporal resolution; and quantify both flow fields (PIV/PTV) and single-cell trajectories using deep-learning trackers. Mixed-donor experiments with spectrally barcoded sperm will reveal whether genetically distinct populations interact neutrally, cooperatively or competitively under confinement. These data will drive multi-scale theory—2D/3D agent-based simulations with hydrodynamic/alignment interactions and coarse-grained continuum models—closing the loop between prediction and device design. Hosted at Warwick’s CMCB (Kantsler: microfluidics; Turner: theory), the work will deliver open datasets, code and validated metrics of collective motility, and seed translation with Cytoswim toward diagnostics that assess “interaction-driven quality” rather than isolated single-cell parameters. Beyond fundamental advances in wet active matter, the outcomes will support animal fertility management in agriculture and conservation, aligning with EU priorities on food security and biodiversity.


**Keywords:** active matter, biophysics, microfluidics, reproductive biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Parameterisation of environmental and physiological controls of volatile organic compound emissions from european forests.' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The overall output of ECOVOC will be a complete instrumentarium to predict terpenoid emissions from major European forest types at the individual source level and to provide it to end users in a uniform format including detailed error assessment and validity check. End users will be among scientists working on scaling from the canopy/landscape level to European scale inventories of BVOC emissions. BVOC inventories were performed in recent years because BVOCs have been recognised to play a relevant role in atmospheric chemistry and ozone formation. The proposed EU emission control strategies (NOx vs. VOC emission control) to reduce tropospheric ozone are dependent on reliable estimates of BVOC emissions from vegetation. It has been assessed that current uncertainty of BVOC emission estimates in the range of a factor 5 must be reduced to 50% to let air chemistry models work properly. The hypothesis that ECOVOC can provide a substantial contribution to the enormous improvement of BVOC inventories required, is based on the fact that (i) European dominant landcover for BVOC emissions is with forests being composed of relatively few tree species, (2) terpenoids are by far dominating BVOC emissions, (3) recent field campaign projects gave clear indications of incorrect assumptions in presently used terpenoid emission models, but improvements are limited due to ubiquitous co-correlation between driving variables in the field. Therefore, by parameterising current field observations, by focussing on terpenoids, and by taking a few common tree species as test case studies for the principal emitter types, ECOVOC can be highly effective and may be the essential of a new quality of BVOC inventories. ECOVOC will not consider emissions at canopy or ecosystem level and will not prepare
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'EOSC Photon and Neutron Data Services'.

assistant: **Objectives**

The ambition of EOSC Photon and Neutron Data Services (ExPaNDS) is to enrich the EOSC with data management services and to coordinate activities to enable national Photon and Neutron (PaN) RIs to make the majority of their data ‘open’ following FAIR principles and to harmonise their efforts to make their data catalogues and data analysis services accessible through the EOSC, thereby enabling them to be shared in a uniform way.EOSC currently provides a range of services that needs to be adapted to the ever-increasing requirements of scientific experiments held at various PaN RIs. It is essential that these services become standardised, interoperable and integrated to fully exploit the scientific opportunities at PaN RIs.ExPaNDS therefore seeks to: Enable EOSC services and to provide coherent FAIR data services to the scientific users of PaN RIs; connect PaN RIs through a platform of data catalogues and analysis services through the EOSC for users from RIs, universities, industry etc.; gather feedback and cooperate with the EOSC governance bodies to improve the EOSC and develop standard relationships and interconnections between scientific publications, PaN scientific datasets, experimental reports, instruments and authors (via ORCID).Concretely ExPaNDS proposes to standardise and link all the relevant PaN RI catalogues to ensure that the user community has access to both the raw data they collect, which is linked to their research session at the various national RIs, and relevant peer review articles produced as a direct result of their usage. It is paramount that we develop a common ontology to fully integrate all the elements of the catalogues as well as a roadmap for the back-end architecture and functionalities. We also propose to develop a powerful taxonomy strategy