RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Carbon-nitrogen interactions in forest ecosystems' (CNTER) targeting Fifth Framework.

assistant: **Abstract**

CNTER is and interdisciplinary collaborative project where data from several hundred study and monitoring sites, and results from long-term nitrogen addition and labelling experiments will be used to gain new insights in carbon(C) and nitrogen (N) interactions in forest soils, especially the effect of N deposition on the soil C sink. Using the European data as well as several regional datasets, the project will identify and validate key parameters and empirical relationships (indicators and transfer functions) relevant to C and N that signify changes in forest ecosystem functioning or environmental impacts. The resembling of long-term N addition experiments will from validation of the identified empirical relationships. Data and process insights will be used to improve and validate dynamic models for prediction in time and space. The major ecosystem impacts we shall consider are(1) changes in forest soil carbon storage, and(2) changes in nitrate concentrations in forest waters.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Proof-of-Concept of a nanobody targeting Osteopontin to inhibit colorectal cancer development' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In this ERC Proof-of-Concept project, we aim to demonstrate the technical and commercial feasibility of a nanobody to target Osteopontin (OPN) for (co)treatment of colorectal cancer (CRC). This proposed project builds further upon recent findings as part of the ERC CRCStemCellDynamics project, in which we showed that OPN plays an important role in clonal expansion and cancer stem cell functionality. CRC accounts for ~10% of all cancers worldwide and forms a heavy financial burden for the EU healthcare system. The 5-year survival rate for patients with CRC is < 60% and for metastatic CRC (mCRC) patients even < 20%. Over the last 15 years, treatment options for CRC have been static and new therapies for CRC are urgently needed.Findings from our lab indicates that a nanobody to block OPN would be an attractive approach for CRC (co)treatment. In this project we will 1) generate a therapeutic nanobody together with key experts in the field, 2) demonstrate efficacy of the nanobody in human CRC xenograft models, 3) compile a “data package” to attract partners for further financing towards commercialisation, 4) establish a solid business plan, including intellectual property (IP) protection, a market/competitor analysis and an exploitation plan, and 5) set up collaborations with pharmaceutical partners for (co)development and/or a licensing deal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Test Infrastructure and Accelerator Research Area' to be submitted under Seventh Framework.

assistant: **Abstract**

The main objective of TIARA (Test Infrastructure and Accelerator Research Area) is the integration of national and international accelerator R&D infrastructures into a single distributed European accelerator R&D facility. This will include the implementation of organisational structures to enable the integration of existing individual infrastructures, their efficient operation and upgrades, and the construction of new infrastructures as part of TIARA.TIARA will enable full exploitation of the complementary features and expertise of the individual member infrastructures, maximizing the benefits for both the owners of these infrastructures and their users. This unique distributed facility will also support the development of an integrated R&D programme embracing the needs of many different fields, as well as medical and industrial sectors, both on technical and human resource aspects.Besides a world-level state-of-the-art distributed R&D facility, TIARA will develop means for establishing and supporting joint accelerator R&D programming, joint education and training programmes and strengthened collaboration with industry.TIARA-PP will deliver a sustainable coordinated European framework for the benefit of- the different fields of science, which need state-of-the-art and/or cost effective accelerators to carry out their research programme- the implementation of the accelerator-based infrastructures identified in the ESFRI roadmap- the different partners (national laboratories, universities, industry) to develop joint projects and exchange expertise on state-of-the-art technologies- European countries to invest and develop their own infrastructures and research centres as parts of TIARA, within an established Europe-wide coordination framework.- Europe as a whole to ensure
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Trophic signaling by gdnf family ligands and their receptors in neuronal development and repair (GDNF)' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The goal of this project is to elucidate novel molecular and cellular mechanisms of nervous system development and repair using the paradigm of the GDNF family offloads and their receptors. GDNF is a potent growth factor for various central and peripheral neurons and has received much attention as a potential therapeutic agent for the treatment of neurodegenerative diseases. Our strategy is to address crucial gaps in the understanding of the role of GDNF legends in neuronal development, function and repair, with the confident expectation that this will reveal new principles of neurodevelopment and neuroprotection of general applicability. To this end, we propose to integrate studies on novel GDNF signalling receptors, GDNF target genes, novel tissue-specific knock-out and transgenic models, development of peripheral and central neural stem cells, and mechanistic bases of neuroprotection in stroke and Parkinson's disease models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Full-scale Demonstration of Replicable Technologies for Hydrogen Combustion in Hard to Abate Industries: The Aluminium use-case', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The H2AL consortium aims to address the challenges of adopting hydrogen (H2) in hard-to-abate industries (HTAIs) through a hybrid approach using digital tools and state-of-the-art experimental techniques. The consortium will develop an integrated H2 burner and support system for a heating furnace in an HTAI, specifically the aluminium scrap recycling industry. The project will investigate the impact of H2 combustion on the furnace structure and product quality while minimizing emissions. H2AL will apply Oxyfuel combustion of H2 as combustion technology, which will be combined with low-NOx combustion techniques, most likely the flameless/MILD combustion mode. This approach will allow us to benefit from the main advantages from oxyfuel combustion while minimizing its emissions (particularly NOx). The impact of H2 combustion on the refractory materials, overall furnace structure and product quality (aluminium) will also be investigated and measures to minimize its impacts will be implemented.To ensure widespread replication and exploitation of the technology, the consortium will perform techno-economic modeling, develop guidelines for technology integration, analyze geographic information, and develop new business models. The consortium comprises 10 partners from four countries, including 4 research organizations, 5 industrial partners, and an industry association, and includes an end-user association representing the aluminium sector in Europe. The H2AL project seeks to achieve TRL7 by running a full-scale demonstration for more than six months, with at least one trial of 100h at 100% H2 and with a thermal output of at more than 2 MWth.


**Keywords:** Oxyfuel combustion; Aluminium, digital tools, holistic approach, full scale demonstration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A high-dimensional approach for unwinding immune-metabolic causes of cardiovascular disease-depression multimorbidities' to be submitted under Horizon 2020.

assistant: **Abstract**

Depression is a common and serious comorbidity of cardiovascular disease (CVD) affecting one in three patients, among which women earlier and more frequently. Depression increases the risk for CVD development, acute events and mortality by >2 fold, independently of traditional risk factors, and constitutes an enormous socioeconomic burden in terms of morbidity, mortality and healthcare costs. Still, the patients at risk, disease trajectories and causative mechanisms involved remain unknown.TO_AITION addresses the hypothesis that immune-metabolic dysregulation, occurring as a result of genetic, lifestyle and environmental risk factors ‘training’ innate immunity, drives low grade systemic inflammation leading to the development of CVD-depression comorbidity. It integrates basic (cell models, immune-metabolic mechanisms, myeloid cell reprogramming), preclinical (animal models, CRISPR genome editing) and clinical (longitudinal cohorts with comprehensive existing data) research, in order to characterise immune-metabolic mechanisms driving CVD-depression comorbidity. Both hypothesis and data-driven strategies will be employed to address causality, focusing on genetic, epigenetic, transcriptional, metabolic and other disturbances leading to the development of comorbidity. Drug-drug interactions and their effects on causative mechanisms and disease trajectories will also be determined. Pathways identified will be evaluated in cell-based and animal models to prove their causal role and obtain mechanistic insight. Finally, new risk models will be developed, and relevant regulatory, cost-effectiveness and feasibility issues addressed. Effective patient-oriented awareness actions, dissemination, exploitation and management activities are also provisioned.TO_AITION will therefore ra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The potency of natural substances in reducing the level of sister chromatid exchange (sce) -inducing dna lesions' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Problem: carcinogens and gyrostatic drugs likecyclophosphamid prorogue DNA damages. A water extract of Viacom album inhibits this DNA damaging effect. However, it is unknown what substances of this extract are responsible of this effect. Project-aim: To identify the DNA protecting substances in the water extract of Viacom album. Result: The result of the project will be a new or an optimised drug to preventing damaging effects of chemotherapy in tumour patients. The SME proposes villa use the results for developing a new pharmaceutical drug for cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transcriptional regulation by TBX18  in vascular development and disease' (TBX18).

assistant: **Concept**

Mural cells (pericytes and vascular smooth muscle) enclose blood vessels and are critical for vascular homeostasis.Absence or malfunction of pericytes or vascular smooth muscle results in aneurysm formation in small or large bloodvessels, respectively. Our previous work showed Tbx18 is selectively expressed in mural cells of multiple adult organs.Preliminary data indicates that, in mice, ablation of Tbx18 in mural cells results in aortic tortuosity and lethality due torupture. These observations led to the hypothesis that transcriptional regulation by TBX18 in mural cells is critical for thedevelopment of functional vascular networks. To fully understand the roles of TBX18 in mural cells and eventually place itas a gene involved in human vascular disease, we propose to: 1) fully characterize the vascular phenotypes of Pdgfrb-Cre;Tbx18 mutants; 2) identify genes directly regulated by Tbx18 in mural cells; and 3) test a putative involvement of TBX18in human aneurysmal diseases.


**Keywords:** Vascular Disease, Aneurysm, Vascular development, TBX18, Transcriptional regulation, Mural Cells
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dual Stimuli-Responsive Nanoparticles to Achieve Brain Multi-drugs Delivery Improving the Treatment of Neurodegenerative Disorders' (BRAVERY).

assistant: **Innovation**

Leading to disability and morbidity, neurodegenerative disorders (NDs) have a profound socio-economic impact. Given the aging of the population, they are raising remarkable concerns. Several active compounds for NDs treatment showed promising results in-vitro but failed in-vivo due to unfavorable biodistribution and limited biocompatibility. The nanocarriers (NC) proposed in the last decade have certainly improved brain delivery of active compounds, however, the limited bioavailability of the drug and biocompatibility issues make NDs treatment still a hot topic in neuroscience. With BRAVERY, I aim to achieve the spatiotemporal controlled drug release improving the bioavailability of neuroactive compounds in the brain without causing neurotoxicity. To do so, I propose to develop a novel biocompatible multi-drug NC capable of efficiently targeting the brain and releasing the loaded drugs in a controlled manner in response to specific stimuli, after intranasal administration. The proposed NC has three fundamental features: 1) It is mucoadhesive; 2) It degrades in response to two specific stimuli that allow achieving a spatiotemporally controlled release of the carried drugs in the brain; 3) Both NC and products of its degradation are biocompatible, thus limiting neurotoxicity. The biocompatibility and biodistribution of the NC will be evaluated by in-vitro, in-vivo, and ex-vivo analysis. As a proof of concept, the carrier will be loaded with active compounds and the biological effect observed will be compared with the one achieved by the free drugs. The project could have an immediate impact on NDs treatment improving the biological efficacy of the anti-prion protein drug used in this project as model drug. Such a versatile biocompatible multi-drug NC will pave the way tow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Demonstration of innovative functional food production systems based on a sustainable value chain of marine and freshwater raw materials for conscientious European consumers' in the context of a Horizon Europe call.

assistant: **Objectives**

NOVAFOODIES will offer novel & competitive functional products to European consumers from a reliable, traceable, and sustainable fisheries and aquaculture value chains. To reach this, NOVAFOODIES is composed of an international consortium covering the whole value chain and expertise: production, processing, transformation, biosecurity, legislation, consumer associations, experts in business, IT, and sustainability. NOVAFOODIES will:-Demonstrate at TRL 6-7, in 10 cases studies, cost-efficient and sustainable fish, micro- and macro- algae production processes that will benefit from natural ecosystem services. -Bring to TRL6 an innovative & sustainable microwave-assisted algae drying process to maximising efficiency and lower costs-Upscaling to TRL 6-7 an innovative biorefinery concept for separation of functional extracts from fish and seaweeds which will be optimised for the technoeconomic and environmental validation. 12 functional food prototypes will be prepared using these extracts as well as fish, bycatch & algae for human products, and aquafeeds, which will be assessed in terms of properties, biosecurity, and standards, and will be brought to consumers by educative activities as e.g. showcookings.-Bring to TRL7 an innovative process to make ecological packaging material from macroalgae-Bring to TRL6 a process to convert the beach wracks material to invertebrate biomass for aquafeeds.-Bring to TRL6 a process to valorise fisheries bycatchs to create novel food for human consumptionNOVAFOODIES will develop a MarketPlatform & Mobile App using IoT technologies and advanced data analysis for tracing & wastes optimisation along the value chain, enhacing consumers trust.Partners are committed to the exploitation of developed technologies, being actively involved in the dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pain relief in palliative care of cancer using home-based neuromodulation and predictive biomarkers' under Horizon Europe.

assistant: **Concept**

More than 50% of cancer patients develop pain before death: 80% can be treated with drugs, but 20% show a low response or have serious adverse effects. Although non-pharmacological interventions such as neurosurgical procedures have been tested, these alternatives are not a preferred option to treat cancer pain due to their high cost, risk, invasiveness and not always proven efficacy. PAINLESS addresses a core component of pain relief, by using an innovative, evidence-based approach. The objective is to adapt and implement a novel, cost-effective, home-based intervention based on neuromodulation to reduce pain and improve quality of life of cancer patients with chronic pain. On the assumption that treatment of chronic pain can benefit from research on the brain mechanisms of pain, we will first attempt to improve our understanding of the role of central pain modulation. The project will be organized in 3 studies: 1) A cohort, longitudinal study (n=450) to explore whether the biomarkers of central pain modulation mechanisms can be predictive of the future occurrence of chronic pain in cancer patients; 2) A cross-sectional study to characterize and stratify cancer patients with vs. without chronic pain (750 patients with the proposed biomarkers and taking into account a number of moderator variables); 3) A pilot study (n=450) to assess the feasibility an efficacy of at-home delivery of transcranial low intensity electric stimulation (tES) for the palliative care of cancer patients suffering from painPAINLESS will develop a customized web portal to share knowledge and to improve management of the patients; perform techno-economic analyses and Health Technology Assessment of the solution; analyze the possibilities of implementation in different European healthcare systems a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The problem of toleration in multicultural society: Time for New Views' to be submitted under Sixth Framework.

assistant: **Abstract**

The project is devoted to research in the field of theory and practice of toleration in multicultural societies with special attention to be paid to comparative analysis of Western and Eastern European societies.The project addresses an obvious need for a new understanding of toleration in culturally, religiously and socially divers societies through overcoming limitations of traditional liberal approach to the problem.Three steps are necessary to develop this theory:- to historicize the idea of toleration, then- to analyse these paradigms by means of philosophical investigation and, finally,- to place them in the framework of contemporary society in order to clarify the relations between toleration and identity, toleration and the liberal state, toleration and democracy and so on.This last part of the project involves comparative analysis of Eastern and Western European societies with the aim of finding paradigms of promoting toleration, relevant for these societies.This means that this project is a constitutively comparative and multidisciplinary one, because it begins as a research in the history of ideas, it continues as a politico-philosophical project and, finally, it comes to its end in comparative investigation of what is usually understood as an area of sociology.The main methods to be used are the methods of conceptual history, discourse analysis, constructivist methods and the methods of comparative analysis.The results of the project will be an educational conception of the methods and tools of promoting toleration in Western and Eastern Europe and a theory of toleration, expressed in a series of articles, a book and electronic publications.As such, the project corresponds to previous projects of the researcher and will be continued after the end of the fell