RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Higher order structure and function of biomembranes'.

assistant: **Objectives**

The biomembrane is a prerequisite of life. It enables the cell to maintain a controlled environment and to establish electrochemical gradients as rapidly accessible energy stores. Biomembranes also provide scaffold for organisation and spatial definition of signal transmission in the cell. Crystal structures of membrane proteins are determined with an increasing pace. Along with functional studies integral studies of individual membrane proteins are now widely implemented. The BIOMEMOS proposal goes a step further and approaches the function of the biomembrane at the higher level of membrane protein complexes. Through a combination of X-ray crystallography, electrophysiology, general biochemistry, biophysics and bioinformatics and including also the application of single-particle cryo-EM and small-angle X-ray scattering, the structure and function of membrane protein complexes of key importance in life will be investigated. The specific targets for investigation in this proposal include: 1) higher-order complexes of P-type ATPase pumps such as signalling complexes of Na+,K+-ATPase, and 2) development of methods for structural studies of membrane protein complexes Based on my unique track record in structural studies of large, difficult structures (ribosomes and membrane proteins) in the setting of a thriving research community in structural biology and biomembrane research in Aarhus provides a critical momentum for a long-term activity. The activity will take advantage of the new possibilities offered by synchrotron sources in Europe. Furthermore, a single-particle cryo-EM research group formed on my initiative in Aarhus, and a well-established small-angle X-ray scattering community provides for an optimal setting through multiple cues in structural biology and function
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'UTILIZATION OF GEOTHERMAL ENERGY ENSURING SUSTAINABLE ENVIRONMENTAL PROTECTION'.

assistant: **Objectives**

The superordinate aim of the present proposal of ensuring sustainable environmental protection by considerably reducing the emission of pollutants caused by fossil fuels in the municipality of Fürstenfeld.Additionally, the project is intended to demonstrate how existing heating systems based on older technologies can be economically operated with a low-temperature supply in combination with block-type thermal power stations and the appropriate type of up-to-date control technology.Economic efficiency will be ensured by multiple utilization of thermal water, i.e. energetic utilization (private heating for agricultural application, folia tunnels for heating of a modern hemp kiln) and material utilization (balnological use for a senior citizen residence for production of medicinal salts).An additional aim consists of ensuring a safe thermal energy supply for the population and of reducing the foreign trade deficit of the Community by using domestic renewable energy resources.Another superordinate aim is the promotion of communication within the Community. This will be achieved by cooperation with EU-partners and, subsequently, by presentation of the project result within our Community.The geothermal system will be used to supply the municipality of Fürstenfeld with hot water for heating purposes. The production well Thermal II is expected to have a wellhead temperature of 75°C at a maximum flow of 30 l/s. The high salt content of the thermal water, however requires the use of a primary heat exchanger (titanium). The thermal water will finally be reinjected to the aquifer using a new well Fürstenfeld Thermal III. The primary heat exchanger, the long distance heating distribution network and the secondary heat exchanger (in every home) reduce the temperature that can be supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Electrolyte, Cathode and Anode Improvements for Market-near Next-generation Lithium Ion Batteries'.

assistant: **Innovation**

The success of electric vehicles in the mass market depends on the development of high-energy batteries at a competitive price. The research efforts of the past decade have continuously improved the energy densities of batteries, yet electric vehicles have only gradually made their way into the market. A combined surge in both consumer demand and industrial “push” is now on the verge of prompting a significant market uptake. eCAIMAN will develop a more powerful battery by modifying and improving individual components and technologies to result in a significant overall improvement of the cell. Key innovations include a 5V high- voltage spinel, a high- capacity composite anode, and a stable high- voltage electrolyte. Their cumulative effect will improve total cell capacity by at least 20%.eCAIMAN will not develop high risk / high gain components, due to the higher the risk of failure. This will ensure the success of the project and deliver a market- near product, while at the same time achieving the goals of the call.eCAIMAN scale-up is designed with existing European production technologies and inexpensive materials mined in Europe, thereby reducing the final battery price. The battery is developed in collaboration with large European light, medium and heavy duty vehicle manufacturers, allowing eCAIMAN to address a broad scope of real end-user demands. eCAIMAN will develop a truly European high-performance battery ready for implementation in the global market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identification of interneurons involved in generating locomotor activity' (2002-2006) targeting Sixth Framework.

assistant: **Abstract**

The mammalian spinal cord contains neuronal circuits that can generate rhythmic flexion and extension movements - the spinal central pattern generator (CPG) for locomotion. Although the CPG determines the basic pattern of muscular activity, sensory feedback is necessary for adjusting motoneuron recruitment and for determining the timing of switching between the stance and swing phases. Stimulation of afferents transmitting information on length and contraction force of extensor muscles is able to reset" the rhythm e.g. initiate a new stance phase. Specific spinal neurons involved in this resetting reflex pathway must also receive information from the CPG to coordinate sensory feedback and the centrally generated rhythmic activity during locomotion.The goal of this project is to characterize spinal neurons involved in resetting reflex pathways from extensor afferents. Candidate cells are best characterized by input from extensor group I afferents and activity during resetting to extension. Previous studies have reported the location of putative resetting neurons and recorded their firing profiles extra-cellularly during locomotor-like activity. Intracellular recordings will now be used to determine the synaptic connectivity and activity of candidate reset ting neurons during fictive locomotion (i.e. motor activity under paralysis) in decerebrate cats.Anatomical reconstructions of stained neurons will be used to determine axonal trajectories and immunohistochemistry will be applied to assess the neurotrans mitters expressed in these neurons. It is of great importance to identify spinal neurons taking part in rhythm generation and to describe their intrinsic properties since other cells involved in generating patterned movements may share many characteristic s of CPG neuro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A non-surgical and long-lasting treatment to substantially reduce back pain', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Stayble Therapeutics AB is a Swedish life science SME developing an injectable treatment (STA-363) for chronic low back pain (cLBP) caused by spinal disc degeneration. STA-363 aims to considerably reduce the patient´s pain in the long-term. CLBP affects the lives of over 50 million people in the EU and U.S., with the total costs for society in the U.S. alone estimated at 100 B$-200 B$ (80 B€ - 160 B€), making cLBP one of the costliest and most disabling conditions globally. Over two thirds of patients with discogenic cLBP are not helped by the conservative treatment options of painkillers and physiotherapy; and only a small fraction are eligible for a spinal fusion surgery, the last line of treatment. Stayble’s patent-pending solution STA-363 offers a cost-effective disease modifying long-term treatment option to bridge this gap in available treatment options. The treatment is currently in Phase Ib clinical trial with final results expected in Q3/2018. Stayble will lead the development of STA-363 through Phase II proof of concept study, and thereafter partner with pharma companies for further development and global commercialisation. The feasibility study, performed under this SME Phase 1 project, will focus on gaining in-depth market understanding on the patient side as well taking a better look at the potential partners and partnering models. The results will strengthen and provide future innovative direction for company’s business plan and commercialization strategy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Explainable AI for Molecules - AiChemist' (AiChemist) under Horizon Europe.

assistant: **Objectives**

Optimising biological activity and physico-chemical properties, while minimising their toxicity, are objectives when developing new compounds in chemical industries. Advanced machine learning (AI) methods are indispensable to this process. They are also increasingly used in environmental chemistry to identify compounds damaging to the environment and humans.   Traditional machine learning (ML) methods provide reliable predictions though only for compounds similar to the training set, thus defining their applicability domain (AD). Emerging representation learning approaches can efficiently approximate the physical interactions of molecules with an accuracy comparable to physics-based methods in only fractions of time. Models based on these representations should have much larger AD due to pre-training on large chemical sets of theoretical values. Here we will develop and benchmark representation learning approaches, addressing their accuracy and ADs, using public and in-house data for endpoints ranging from chemical reactions to toxicity.   While explainable AI (XAI) methods are actively developing in the ML community, there is a gap with their use in chemistry, i.e. there is a need to translate their results to the end users, chemists and regulatory bodies. Since the research program is tightly coupled with the target users - large companies, regulatory agencies and SMEs - it provides a clear path for technology transfer from academia to industry.  AiChemist will provide structured training to its fellows through a combination of online courses and schools, strengthening European innovation capacity in the education of specialists in AI methods. The fellows will receive comprehensive training in transferable skills. The complementary expertise and strong commitment of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Effect of controlled hyaluronan synthesis on the stemness of aged mesenchymal stem cells', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Hyaluronan (HA), a linear polysaccharide in the extracellular matrix (ECM) of higher animals is a key player in tissue remodelling. Mesenchymal stem cells (MSC) exhibit multipotential differentiation capacities and are therefore of high clinical importance. Novel cell therapeutic approaches based on the differentiation and regeneration potential of MSC have been developed and successfully applied in numerous clinical studies.The stemness of MSC is described by their ability to form colonies and to differentiate into mesenchymal tissues. Prior clinical applications MSC are propagated in vitro to increase the number of multipotential cells and thereby maximising the chance of a therapeutic success. So far however, cell expansion can only be achieved at the expense of MSC stemness and diminished multipotentiality.The aim of this project is to unravel forces that drive these detrimental processes during MSC propagation. In particular, the proposed work addresses alterations in HA content of the extracellular matrix during cultivation. Depending on the HA length, cell proliferation and differentiation is either inhibited or promoted. High molecular weight HA restrains cell division whereas short HA fragments are shown mitotic.Hyaluronan synthases (HAS) generate the unbranched biopolymer at the plasma membrane. HAS are differentially expressed when comparing young against aged cells. In particular HAS3 was found to be upregulated in senescent fibroblasts and MSC. The goal of this project is to investigate the role of HAS3 during MSC ageing and to rate whether elevated levels of HA production advances the progression of cell senescence. We hypothesise that controlling the HA content in the pericellular space may not only allow to decelerate the progression of MSC senescence bu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'NEW PATHWAYS TO GENDER AND EQUALITY IN RESEARCH AND INNOVATION IN THE EUROPEAN UNION' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

This is a proposal for a two-day conference to be held in 23-24 October 2019 in Helsinki under the topic of gender equality in research and innovation. The among the objectives of the conference are the following: 1.The proposed Conference will hold discussions that provide the basis for future action under four general themes: •Institutional or structural change of gender equality in research and innovation.•Intersectionality, diversity and other dimensions of equality in research and innovation to complement the gender equality dimension. •Gender equality dimension in the fields of digitalization, artificial intelligence and robotics. •Gender equality in innovation activities, especially in the private sector. These themes connect the conference to the ongoing discussions and developments in the research and innovation area.2.Another important objective is to focus on the future of equality in research and innovation and the next steps necessary to ensure progress for the future strategy and actions at national EU and global level. 3.The Conference will also look at the achievements of the past 20 years and lessons learned in European gender equality policy development in particular with established instruments, involvement and collaboration. One of the main focus of the Conference will be to discuss how to utilize what we have learned in bringing forth a new and improved vision for gender issues in research and innovation.


**Keywords:** gender, equality, research, innovation, conference
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'AIR FOReCast in Europe'.

assistant: **Concept**

The continuous increase of the number of air passengers in Europe (140 million passengers a year increasing by nearly 10% a year), together with the growing competition due to the easing of restrictions on trade is a permanent challenge for the airports and airline companies:· Airports must schedule complex movement operations that are often distorted at the last moment by local traffic perturbation but also by cumulative delays coming from other parts of Europe. The emergence of the shuttle concept, where no reservation is necessary, further complicates the task,· Airline companies have to organise logistic and maintenance operations, adjust their fleet and provide the best optimised carrier size for each destination, reserve slot allocations a very long time in advance according to expected passengers flows in Europe or in the world.High performance tools or services able to predict the movements of passengers are required to help these companies to adjust their offer as closely as possible to the demand, or more simply to optimise their resources, would they be human or material. However, the complexity of these movements together with the random aspect of people's travel needs make it difficult to produce an adequate modelling based on reasoning or expertise.Recent progress in data mining algorithms, if applied to this domain, could however allow to find correlations between causes and results in huge masses of events where a human being would simply be overwhelmed. Associated with an intelligent monitoring and interpretation of the information available on the Internet, these methods can be the seed of very innovative and efficient forecasting tools.Objectives:To provide better services to their customers or simply to optimise their resources, airports and airline
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Decision support system for local sustainable development based on eco-budget methodology' in the context of a Fifth Framework call.

assistant: **Objectives**

The concept of environmental budgeting emerged from the definition of sustainable development stated in the Aalborg Charter. The concept involves the setting up of an environmental budget (ecoBudget) plan for a single year, passing it through the council, executing it, and evaluating the actual environmental spending in an environmental budget balance.The objective of the DESTINY project is the development of a unified computer-based decision support system (DSS) designed to enable local authorities to implement the ecoBudget concept. It allows environmental priorities within the principles of sustainable development to be determined, the monitoring of progress against environmental plans, and the communication of results. The DESTINY target users are the local authorities, regional authorities as supervising users, and industries with an environmental impact.Objectives:The objective of the DESTINY project is the development of a comprehensive computer-based decision support system (DSS) designed to enable local authorities to implement the eco Budget concept. It allows setting of environmental priorities for sustainable development; monitoring of progress against environmental plans and dissemination of outcomes to others via Internet.The DESTINY target users (and customers) are:1. Local Authorities, as the direct user of the DESTINY tools2. Regional Authorities as supervising user3. Industries, for evaluating their environmental impact.A key element of DESTINY will be the facility for access by both elected representatives and the general public.Work description:The DESTINY project will be performed in four phases:PHASE 1: Preparation & system specification. The tasks are: Overall requirements for DESTINY including user requirements and the international framework on