RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A Human Neural Platform for Assaying Antigen-Antibody Interactions for Autoimmune Encephalitis' in the context of a Horizon 2020 call.

assistant: **Objectives**

Autoimmune encephalitides (AE) are a category of diseases that result from an immune attack against proteins present in patient’s own brain cells (antigens). Clinical symptoms include both neurological and psychiatric manifestations, that differ greatly between patients and during disease progression. Upon prompt diagnosis and immunotherapy symptoms gradually resolve. Current epidemiological studies estimate an annual incidence of encephalitis of any aetiology is 2-3 patients per 100.000 per year. However, given that new autoantibodies are being discovered on a half-yearly basis, the incidence of AE is increasing over time and is nowadays comparable to infectious encephalitis. Methods to diagnose AE rely on immunodetection of autoantigens, using rat brain tissue or transfected cells as a source of neural cell surface proteins. Despite being successful in identifying known autoantibodies, in 50% of all AE cases the affected antigen is unknown and cannot be detected using current technologies. Therefore, there is an urgent clinical need for a diagnostic kit that is able to detect all cell surface neuronal antigens. Thanks to the skills acquired during the ERC-StG, we have developed a platform to identify the presence of autoantibodies against neuronal surface antigens in patient serum or CSF using human induced pluripotent stem cell (hiPSC) derived neural cells. Moreover, first experiments validate that our technology can detect an autoantigen in seronegative samples. In the context of this project, we aim to conduct the necessary steps to bring a successful diagnostic approach developed in the bench towards its application as a diagnostic device at the bedside. To this end, we will develop a minimum viable product (MVP), to assess its capability to detect new AE-associat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Structural characterisation of early alpha-synuclein amyloidogenic species relevant to Parkinson's disease: Validation as therapeutic targets' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Alpha-synuclein (AS) is the major constituent of Lewy bodies, a pathological signature of Parkinson’s disease (PD). Amyloid-like deposits of AS are generated by toxic pre-fibrillar species of the protein which are now considered to be a major cause of cell death in PD. The mechanisms by which oxidative stress is linked to AS aggregation are not yet known and are a subject of intense research in the field. The most appealing hypothesis is the one of oxidation-mediated oligomerization of AS, causing the formation of highly toxic early amyloidogenic species. Such intermediates appear to be scarcely populated, likely involving important structural rearrangements, what makes them ideal targets for drug intervention. The focus of this research proposal is to characterise the structure and thermodynamics of early AS amyloidogenic species, both the molten globule-like conformation of monomeric AS, reported to be key intermediate in fibril formation, and small early soluble oligomers populated in different conditions. The study of the early stages of fibrillogenesis requires the development and application of new methods. We propose tackling this challenge in a novel way, through exciting multidisciplinary research by scaling up the NMR techniques combined with methods of molecular dynamics simulations, together with the use of the more advanced single-molecule fluorescence techniques. In addition, the impact of metal-catalized oxidation in the structure of monomeric and oligomeric AS by means of low and high resolution structural techniques will be evaluated, shedding light into the role of oxidative damage as an effector in protein aggregation. The information obtained will be paramount in order to validate the use of pharmacological chaperones of AS as new therapeutic agents
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'ZETAMIX, the first Desktop Ceramic 3D printer on the market' under Horizon 2020.

assistant: **Concept**

NANOE is an SME evolving on the Ceramic Engineering market for 10 years, as a manufacturer of ready-to-sinter and high-purity nanopowders for the industry. NANOE innovated on that market by allowing its clients to use its powders in a standard production process, by resolving difficulties linked to powder’s fineness. With the development of a complete range of ceramic materials and high industrial production capacities, NANOE rapidly succeeded in increasing its turnover. To further increase its development, NANOE diversified its activities on the Additive Manufacturing (AM) market, where the only commercialized Ceramic printers, based on stereolithography and binder-jetting technologies, stay complex to use and costly. Instead of adapting printers to the production of specific raw-materials, NANOE adjusted Ceramics’ binding formulation, so that it can be used on desktop printers already available on the market. ZETAMIX will be the first range of ready-to-use ceramic filaments that can be used with common desktops 3D printers worldwide. Thanks to ZETAMIX, industrials will be able to print quicker high-quality technical ceramics in small series, at any time and for an entry-price of €10 000. NANOE commercialized a first version of its ZETAMIX filaments, which is currently produced at a laboratory-scale and tested within some companies. Thanks to its numerous competitive advantages, its unique approach, its existing network of resellers and the recognition of its brand, NANOE should rapidly expand on the technical materials for AM market. NANOE will first target the markets segments of automotive, aeronautics and energy and rapidly expand on international markets. NANOE still have to solve technical challenges regarding filaments’ facility of use and parts quality. These d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Genetic induction of the defence reaction cf-9/avr9 in plants'.

assistant: **Objectives**

The recent isolation of the tomato resistance gene Cf-9, effective against the fungal pathogen Cladosporium fulvum, by transposon tagging may provide a new strategy for broad spectrum diseaseresistance. Plants that carry the corresponding Avr9 gene, and which exhibit somatic excision of Ds from Cf-9 show a variegation for defence-related necrosis. This leads to induction of the plant defence mechanisms and a broad spectrum suppression of disease. The enhanced resistance exhibited in the plants variegating for necrosis has been termed Genetic Aquired Resistance (GAR). The specific objective of this research is to engineer resistance against all races of Phytophthora infestans (late blight fungus) into existing commercial potato cultivars. Tobacco will also be transformed as a test plant . Previous studies in tomato show that plants with a high frequency of small necrotic sectors produce the best resistance phenotype. To apply GAR to potato plants two strategies will be adopted to manipulate the frequency of somatic restoration of Cf-9 function. In System 1, an Ac element with low levels of excision will be inserted in theCf-9 sequence. In System 2, plants carrying a Cf-9 with a Ds element insertion will be crossed with plants carrying a TPase directed by different promoters. For both systems the T-DNA containing Cf-9* will also carry the 35S: Avr9 transgene. The variegation for necrosis observed in the GAR plants will be correlated with the effectiveness of protection against different pathogens. In addition, the elements involved in the defence signalling pathways will be analysed by crossing the GAR plants to transgenic plants containing genes that alter various potential signal pathways (eg NahG, SOD, catalase).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dilute Bose Gases at Positive Temperature' (DEBOGAS) under Horizon 2020.

assistant: **Objectives**

The experimental realisation of Bose-Einstein condensation (BEC) in trapped alkali gases in 1995 triggered numerous mathematical investigations of the properties of dilute Bose gases. For the mathematical description of these experiments the Gross—Pitaevskii (GP) limit is relevant. In the past two decades there has been a substantial progress in the understanding of ground state properties of Bose gases in the GP limit, culminating in the recent rigorous justification of Bogoliubov’s theory for the ground state energy and for low lying excitations. Except for a recent contribution of me and my co-authors [1], the highly relevant GP limit at positive temperature has not been considered so far. The aim of the proposed project is to develop new mathematical tools to study dilute Bose gases at positive temperature. This will be done from two points of view: Thermodynamics and Dynamics. More precisely, in the first part of the project I plan to prove refined estimates (w.r.t. [1]) for the free energy in the GP limit which would yield a better understanding of how interactions affect the thermodynamic properties of such systems. In the second part I will investigate the dynamics of positive temperature states after the trapping potential will have been switched off and prove that a certain structure of the 1—pdm is stable under time evolution. Apart from asking two highly relevant questions in modern mathematical physics, the project is also interesting from a physics point of view since it would justify two frequently used approximations in the physics literature.  [1] A. Deuchert, R. Seiringer, J. Yngvason, Bose-Einstein Condensation in a Dilute, Trapped Gas at Positive Temperaturre, Commun. Math. Phys. (2018). https://doi.org/10.1007/s00220-018-3239-0


**Keywords:** Mathe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Inherited risk of breast and prostate cancer' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Linkage studies of cancer families have identified high-penetrance cancer genes such as BRCA1 and BRCA2. However, although these genes have resulted in novel insights into cancer, it is clear that a large component of inherited cancer risk remains unacc ounted for. It has been proposed that common low penetrance cancer susceptibility genes contribute significantly to the genetic predisposition of cancer in a polygenic model of inheritance. Association studies have been suggested as the method of choic e for finding susceptibility alleles of high frequency but low penetrance. Here, we propose to take advantage of accumulating genomic data and two European populations of different history and structure to determine the contribution of candidate cancer susceptibility genes to different clinical forms of breast and prostate cancer. We will use a population based association study in Iceland and the Netherlands to map the risk profiles associated with common polymorphic variants in and near candidate c ancer susceptibility genes in breast and prostate cancer patients. We will also develop methods for statistical analysis of complex genomic data which can be used in this and other projects. The proposed study has the potential to cast light on how gen etic variants affect the risk of cancer initiation and how it affects progression and response to treatment. Finally, the results may serve as a starting point for building models of genetic risk of these cancers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Portable and fully automatic sampling and measuring system for Dioxin /Furan emission in gas streams' under Fourth Framework.

assistant: **Concept**

There is no measuring system available on the market for the monitoring of Dioxin/Furan-emissions in the industrial combustion gas streams of for example waste incinerators, chemical production processes and steel making plants, that is easy to handle and accurate in measurement. The aim of the project is to develop a measurement unit for short and long-term sampling of Dioxin/Furan-Emissions that is portable, fully-automatic and will be able to reduce the building-up time from today's 4 - 8 h. to approx. 30 min. The development will be in 2 steps: the first step is to search for the best analytical process for the system; the second step will be to develop the sampling system which works fully-automatically and is easy to handle. The system must be portable and cheap. At the end of the development there must be a system of sampling unit and analytical process which is very accurate, easy to handle, portable and cheap. In this case there will be a great market in Europe for such a system and a very good chance for SMEs in Europe to get a new successful product onto the market.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Designing and Enabling E-infrastructures for intensive Processing in a Hybrid DataCloud' (DEEP-HybridDataCloud).

assistant: **Concept**

The key concept proposed in the DEEP Hybrid DataCloud project is the need to support intensive computing techniques that require specialized HPC hardware, like GPUs or low latency interconnects, to explore very large datasets. A Hybrid Cloud approach enables the access to such resources that are not easily reachable by the researchers at the scale needed in the current EU e-infrastructure. We also propose to deploy under the common label of “DEEP as a Service” a set of building blocks that enable the easy development of applications requiring these techniques: deep learning using neural networks, parallel post-processing of very large data, and analysis of massive online data streams. Three pilot applications exploiting very large datasets in Biology, Physics and Network Security are proposed, and further pilots for dissemination into other areas like Medicine, Earth Observation, Astrophysics, and Citizen Science will be supported in a testbed with significant HPC resources, including latest generation GPUs, to evaluate the performance and scalability of the solutions. A DevOps approach will be implemented to provide the chain to ensure the quality of the software and services released, that will also be offered to the developers of research applications. The project will evolve to TRL8 existing services and technologies at TRL6+, including relevant contributions to the EOSC by the INDIGO-DataCloud H2020 project, that the project will enrich with new functionalities already available as prototypes, notably the  support for GPUs and low latency interconnects. These services will be deployed in the project testbed, offered to the research communities linked to the project through pilot applications, and integrated under the EOSC framework, where they can be further scaled
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'inter-Sectoral Training for Research on the pathology and prevention of Indwelling Device associated infEctions' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

iSTRIDE will educate young scientists to develop innovative solutions to reduce the high incidence and mortality of Indwelling Device Associated Infections (IDAIs). IDAIs can be associated with urinary and intravenous catheters and cardiovascular devices, and result from microbial transfer and biofilm formation on the device surface. The clinical burden of IDAIs is significant and can be life threatening, while difficult to diagnose and to treat due to the high antibiotic tolerance of biofilm cells.  While there are antimicrobial device coatings available, their effectiveness is limited.iSTRIDE’s first objective is to provide a platform for young scientists to pursue a highly inter disciplinary PhD training focused on translational skills towards a career in biomedical research and medical technology development. iSTRIDE’s second objective is to address the challenges of IDAIs by developing novel antimicrobial coatings for indwelling devices and improved diagnostic tools to monitor their efficacy, by building on realistic IDAI models that represent all aspects of infection.iSTRIDE relies on a carefully selected inter-sectoral project consortium (six hospitals, one   research institute, seven universities and three industrial partners) that crosses disciplinary borders (microbiology, material sciences and diagnostic technology). The iSTRIDE training programme is structured so that each DC will work on the interface of at least two of these disciplines via the host lab and secondments. The consortium includes expertise from the clinical, engineering, polymer chemistry, microbiology, soft matter engineering and cell biology domains, and involves companies active in advanced diagnostics and the medical device industry. Partner organisations from different regions of Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'MAGNETIC NANOCONTAINERS FOR COMBINED HYPERTHERMIA AND CONTROLLED DRUG RELEASE', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of this project is the assembly and the fabrication of a new generation of multifunctional nanostructures for performing combined hyperthermia and controlled drug release, specifically targeted to cancer cells. The “magnetic nanocontainers” we intend to develop can perform at the same time cell recognition, hyperthermia treatment, and, as a consequence of the heat and /or cell environment stimuli, the release of drug with high selectivity for ovarian carcinoma. These multifunctional tasks are made possible due to the inclusion of three main components: a) the magnetic nanoparticles, allowing detection by MRI, cancer treatment by hyperthermia and providing stimuli for drug release; b) the nanocontainers, which allow for drug encapsulation and protection from degradation, facilitate the release of the drug upon application of an external stimulus, such as heat, or an internal one, such as the acidic pH of the tumour cells; c) the antibody fragments attached to the surface of the magnetic nanocontainers to deliver them selectively to the ovarian cancer cells. The individual building blocks and their assemblies will be characterized with respect to physical, chemical, and biological features, followed by dissemination of the newly acquired knowledge. Cell culture experiments will allow to understand the performance of such nano-tools in vitro. Directed towards application in patients, in vivo animal studies will be carried out on the most successful magnetic nanocontainers. The objectives of this proposal cover a wide range of scientific fields, hence a truly interdisciplinary collaboration between chemists, physicists, and biologists is required. To this end, we propose a european network collaboration between academic partners, who will take care of the developmen