RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional characterization of neuroactive toxins using an engineered bacterial type-III secretion system' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Toxins occur in a broad diversity in nature and are produced by a wide array of organisms, including spiders, snails, or plants. Conotoxins are a class of toxins that are synthesized in the venom duct of the marine cone snail, genus Conus. The venom of each Conus species is composed of 100 different toxins that rapidly affect the prey organism at multiple targets. The majority of toxins target ligand-gated or voltage-gated ion channels. Each neuroactive peptide of the venom is highly specific for an individual channel isoform.The applicant proposes to develop in an interdisciplinary approach engineered bacteria that export neuroactive peptides and proteins into the surrounding media, readily available for subsequent characterization. The applicant will utilize the powerful flagellar type-III secretion system of Salmonella enterica for the expression and secretion of recombinant neuroactive peptides. The flagellar-specific type-III secretion apparatus selectively exports substrate proteins at a rate up to 10,000 amino acid residues per second and can be readily manipulated by genetic methods. The applicant will create a Salmonella peptide library based on cDNA isolated from the venom duct of cone snails and use the type-III secretion system as an export shuttle to transport non-flagellar peptides into the surrounding media. The media supernatant or (partially) purified peptides will be analyzed for neurotoxic activity by imaging cellular calcium levels of dorsal root ganglia cells.This innovative approach for the rapid purification of neuroactive compounds using secretion via the well-characterized flagellar type-III secretion apparatus will allow to identify and characterize novel toxins with distinct target specificity. Due to their unique mode of action and their abil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Stroke diagnostic imaging performed with ultrafast ultrasound localization microscopy (uULM)' (ResolveStroke).

assistant: **Innovation**

Each year, stroke kills 6 million people worldwide and permanently disable another 5 million. The prognosis is defined by the extent of the stroke, along with the rapidity by which it is identified and treated. Current diagnostic imaging, MRI and CT, require specialized centers and time. Even though ultrasound could provide a rapid and portable diagnostic tool, it is currently constrained by diffraction, which yield a theoretically incompressible compromise between the penetration in depth and through the skull with respect to the minimum detectable vessel size.We have recently demonstrated that the diffraction limit in ultrasound imaging can be surpassed in the rat brain in-vivo [Errico et al. Nature 2015]. Inspired by FPALM, Ultrafast Ultrasound Localization Microscopy (uULM) can reach resolutions of a tenth of the wavelength, in-depth with a clinical contrast agent and scanner. It is now possible to use lower ultrasound frequencies, which easily penetrate the skull and travel deep into tissue, to observe vessels at the micron-scale. In the context of stroke diagnosis, we propose to use uULM to reconstruct the entire human brain vasculature, within a few minutes, with a portable ultrasound system positioned on the patient’s head. First, the project ResolveStroke proposes to develop an animal trans-skull vascular scanner to define biomarkers linked to stroke. 3D mapping at the capillary scale will allow us define new anatomical and physiological biomarkers. Secondly, a human system will be built, initially fully-sampled but eventually smaller and portable. The last stage will consist in a proof-of-concept of the ultrasonic angiogram in patients with subacute ischemia. By saving previous time and, hence, brain tissue, we believe that a portable ultrasound system that co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Micro- and Nanostructured Polysaccharide Interfaces' to be submitted under Seventh Framework.

assistant: **Abstract**

Natural polysaccharides (PS) and their derivatives provide a huge variety of functional groups leading to a great number of different physicochemical properties. Therefore functional polysaccharides are promising for the coating of man-made materials such as polymer surfaces, glass or ceramics in order to increase their functionality or biocompatibility. An elegant way to obtain coatings of natural polysaccharides is shaping of trimethylsilylated PS derivatives and subsequent regeneration of these structures to the initial PS. The target of this study is to produce electrospun and spin coated polysaccharide coatings from blends of hydrophobic trimethylsilylated PS and other hydrophobic PS derivatives and to subsequently regenerate these structures to the PS with the initial (bio-)function. This will produce functional polysaccharide coatings with tunable micro- and nanofibrous structures on a variety of materials. The influence of the structure and PS composition of these coatings on the physicochemical properties will be determined by surface analytical tools (Contact Angle Measurements, X-ray Photoelectronspectroscopy). The biocompatibility of the materials will be evaluated by extended protein adsorption studies with a quartz crystal microbalance. The regeneration process from trimethylsilylated PS will it further allow to introduce micropatterns on the PS surface coatings by lithographic methods. Spatially separated regeneration of the PS derivative coatings will produce patterns of electrospun or spin coated functional PS on substrates surrounded by non-regenerated hydrophobic PS derivatives. With the approaches described in this proposal, a vast number of tunable functional polysaccharide interface will be produced which will have potential applications as anti fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'HUMAN-IN-THE-LOOP TELEPRESENCE CONTROL FOR ROBOT-ASSISTED SURGERY' to be submitted under Seventh Framework.

assistant: **Abstract**

In teleoperated robot-assisted surgery, a surgeon operates master manipulators to control the motion of remote robotic manipulators. The manipulators at the remote side enter the patient's body through very small incisions. The patient benefits from the advantages of minimally invasive surgery, while the surgeon's performance is improved by high dexterity and precision inside the patient's body. However, the effectiveness of current clinical systems is limited by the lack of force feedback to the operator. Some surgical procedures, such as exploratory palpation, cannot be performed via MIS. For others, the addition of force information will improve the safety and quality of operation.Robotic teleoperation systems in critical environments must be stable and transparent. In the classical approaches to analysis and control of teleoperators, there is an inherent trade-off between these two design goals. However, these approaches do not take into account models of the human operator. In previous studies, we explored transparency and the human operator. Here, we intend to explore the human operator influence on stability, and develop new control methods for teleoperated surgery that consider biomechanical and neurological models of the operator.In particular, we will push the boundary of the stability-transparency tradeoff, and maintain stable system performance with useful force feedback. To achieve this, we will collaborate with surgeons to identify performance measures and perception goals. We will develop human-in-the-loop stability analysis and use recent results in human motor control to develop the control methods. These will be applied on a custom research version of a clinical robotic surgery system in realistic surgical tasks.This study is expected to enable effecti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ACTivating InnoVative IoT smart living environments for AGEing well' (ACTIVAGE).

assistant: **Innovation**

ACTIVAGE is a European Multi Centric Large Scale Pilot on Smart Living Environments. The main objective is to build the first European IoT ecosystem across 9 Deployment Sites (DS) in seven European countries, reusing and scaling up underlying open and proprietary IoT platforms, technologies and standards, and integrating new interfaces needed to provide interoperability across these heterogeneous platforms, that will enable the deployment and operation at large scale of Active & Healthy Ageing IoT based solutions and services, supporting and extending the independent living of older adults in their living environments, and responding to real needs of caregivers, service providers and public authorities. The project will deliver the ACTIVAGE IoT Ecosystem Suite (AIOTES), a set of Techniques, Tools and Methodologies for interoperability at different layers between heterogeneous IoT Platforms and an Open Framework for providing Semantic Interoperability of IoT Platforms for AHA, addressing trustworthiness, privacy, data protection and security. User-demand driven interoperable IoT-enabled Active & Healthy Ageing solutions will be deployed on top of the AIOTES in every DS, enhancing and scaling up existing services, for the promotion of independent living, the mitigation of frailty, and preservation of quality of life and autonomy. ACTIVAGE will assess the socio-economic impact, the benefits of IoT-based smart living environments in the quality of life and autonomy, and in the sustainability of the health and social care systems, demonstrating the seamless capacity of integration and interoperability of the IoT ecosystem, and validating new business, financial and organizational models for care delivery, ensuring the sustainability after the project end, and disseminating t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Lightweight Innovative Generator for Future Air Transportation' in the context of a Horizon 2020 call.

assistant: **Objectives**

LIFT will deliver a beyond state of the art solution for lightweight non-active components for a megawatt range electrical machine proposed for Clean Sky 2 Large Passenger Aircraft IADP work package 1.6.1 as defined in the Topic Description JTI-CS2-2017-CfP07-01-4.As stated in the Topic Description, the non-active parts of electrical machines contribute to 30-40% of the weight of the machine. LIFT proposes a number of solutions to reduce the mass and the weight of these non-active parts ranging from using composites or metal foams to corrugated structures that are all within the expertise of the University of Nottingham. In total, our preliminary workings illustrate that it is possible to deliver a mass and weight saving of at least 50% using a combination of technologies without significantly diminishing performance. As a result of the research and innovation activities within the project, UNOTT foresees the generation of new knowledge in the following areas: · An innovative MW-class generator with a record power density in excess of 25kW/kg will be developed · Innovative thermal management systems will be developed exploiting the voids within lightweight materials · A new family of lower-noise e-machines will be incepted, taking advantage of the voids within lightweight materials · Development of novel mechanical models and advanced manufacturing methods for cylindrical lattice materials  as required for e-machine designs, backed up by experimental testing · The power density boundaries and limitations charts for future aerospace PM machines will be established for different speeds
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Initial Training for Atmospheric Remote Sensing'.

assistant: **Objectives**

This proposal brings together a group of universities, research organisations and high-tech companies from different disciplines (meteorology, geosciences, physics, electrical engineering, mathematics) with the aim to foster training and further development in the area of  remote sensing of the atmosphere. The last years have brought a rapid development in instrumental techniques, i.e. lidar, radar, radiometry, that have great potential to monitor atmospheric composition and dynamics in unprecedented detail. Such instrumentation is urgently needed to address important topics related to climate change, numerical weather forecasting, and atmospheric pollution. Most prominently aerosol-cloud interaction as the single largest uncertainty in current climate projections requires the exploitation of emerging observational techniques to improve the parameterisation of aerosol and cloud processes in atmospheric models. Because today’s curricula do not reflect these issues, ITARS (Initial Training for Atmospheric Remote Sensing) aims•to impart an in-depth understanding of instrumentation and algorithms needed to retrieve geophysical quantities and atmospheric applications,•to foster the synergy of different sensors by bringing together experts from the individual techniques,•to develop and implement pan-European courses on atmospheric remote sensing by exploiting new web-based techniques, and•to close the gap between the specialized development of single instruments and atmospheric applications by training a new generation of scientists in academia and the private sector.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Positive energy representations of the loop group of so(n) and operator algebras'.

assistant: **Concept**

Our main object of study is the positive energy representation theory of the loop group LSO(N) of the compact Lie group SO(N). This should lead to a complete study of the fusion ring of LSO(N) at any level l and will be submitted as a Ph.D. dissertation in Pure Mathematics at the University of Cambridge. Since 1988, it has been realised that positive energy representations of the loop group LG = C'infinity'(S1, G) of a compact Lie group G can be studied using von Neumann algebras (J1, J2) Their finite dimensional prototype, the representations theory of the classical groups was understood in two stages. First, the irreducible representations were classified, the decomposition of their tensor products studied For loop groups, the natural class of irreducible representation are the (projective unitary) positive energy ones Defining a tensor product or fusion operation is a difficult problem since the naive one does not work There have been various proposed definitions (Bo, KL, S). The von Neumann algebra approach, successfully implemented for the loop group of SU(N) (Wal, Wa2) and the diffeomorphism group of the circle (L) uses Connes' tensor product operation on bimodules over a von Neumann algebra. The work of Wassermann (J2, Wal, Wa2) on the loop group of SU(N) shows that the computation of fusion reduces to understanding the properties of primary fields, the building blocks of Conformal Field Theory. Of particular importance are their analytical properties, when they are viewed as operator valued distributions and their braiding or commutation properties. The latter are related to the monodromy of a 1st order PDE, the Knizhnik-Zamolodchikov equation and can in principle be derived from a detailed analysis of its solutions. Once the braiding and analytical properties a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'safeGUARDing biodivErsity aNd critical ecosystem services across sectors and scales' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

GUARDEN’s main mission is to safeguard biodiversity and its contributions to people by bringing them at the forefront of policy and decision-making. This will be achieved through the development of user-oriented Decision Support Applications (DSAs), and leveraging on Multi-Stakeholder Partnerships (MSPs). They will take into account policy and management objectives and priorities across sectors and scales, build consensus to tackle data gaps, analytical uncertainties or conflicting objectives, and assess options to implement adaptive transformative change. To do so, GUARDEN will make use of a suite of methods and tools using Deep Learning, Earth Observation, and hybrid modelling to augment the amount of standardized and geo-localized biodiversity data, build-up a new generation of predictive models of biodiversity and ecosystem status indicators under multiple pressures (human and climate), and propose a set of complementary ecological indicators likely to be incorporated into local management and policy. The GUARDEN approach will be applied at sectoral case studies involving end users and stakeholders through Multi-Stakeholder Partnerships, and addressing critical cross-sectoral challenges (at the nexus of biodiversity and deployment of energy/transport infrastructure, agriculture, and coastal urban development). Thus, the GUARDEN DSAs shall help stakeholders engaged in the challenge to improve their holistic understanding of ecosystem functioning, biodiversity loss and its drivers and explore the potential ecological and societal impacts of alternative decisions. Upon the acquisition of this new knowledge and evidence, the DSAs will help end-users not only navigate but also (re-)shape the policy landscape to make informed all-encompassing decisions through cross-secto
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Cinematic Battle for the Adriatic: Films, Frontiers, and the Trieste Crisis' to be submitted under Horizon 2020.

assistant: **Abstract**

The project will analyse cinematic practices related to the Trieste Crisis (1945-54), a diplomatic struggle over the Italo-Yugoslav border at the outset of the Cold War, which remains the region’s most controversial issue due to the violence it invoked. Central to the conflict’s soft power dimension, both countries produced a collection of films about these events, which coincided with the establishment of film festivals as important geo-political events. Taking festivals as lieux de mémoire, the project will explore how the conflict’s cinematic representation (specifically the foibe massacres, the Italian exodus, the fascist crimes and the anti-fascist struggle) has been employed to construct desirable cultural memories related to its national and ideological concerns. It will compare Italian and Yugoslav (Slovenian, Croatian) perspectives, by investigating three levels of cinematic action: 1) film production, 2) film festival circulation, and 3) film reception through awards and press reviews. It will compare two periods, both marked by higher interest in this topic: the Trieste Crisis itself and the period following the establishment of Giorno del Ricordo in Italy in 2004. By including historical and contemporary viewpoints, the study will examine how the narrativization of these events has evolved from the early Cold War to the present day. The project will result in a digital archive presenting: 1) film database with contacts of institutions housing the films, 2) film analysis in the given political and social context 3) selection of films and archival documents. The project will offer the first analysis of this film corpus and make widely accessible a collection of related cinematic cultural heritage. In engaging with an interdisciplinary approach, it will provide