RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced Teaching and TRaining for Adoptive Cell Therapy' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Considerable resources are devoted to fighting cancer throughout Europe, yet these efforts are not producing the results that health practitioners and citizens might expect. This is partly due to the fragmentation and duplication of research efforts within Member states and the lack of co-ordination at European level. However it can also be attributed to the need to retain and most importantly develop researchers within the EU who have the research skills required to make a real contribution to cancer treatment. The need for quality researchers is particularly acute within the emerging interdisciplinary field of Adoptive Cell Therapy. This promising advance in cancer treatment is based on the exploitation of tumour immunology and genetic technology and built on the specific ideas and techniques originally proposed by the European and Israeli scientists who are members of the ATTRACT network. To facilitate further development within the field of adoptive cell therapy, it is crucial that a co-ordinated and intersectoral approach (combining both the research community and industry) is taken, an approach that broadens the portfolio of skills currently retained within the EU research community. Through the integration Europe’s undisputed leaders in the field of adoptive cell therapy established in the 2005 FP6 ATTACK project, the ATTRACT network aims to foster the development of a pool of ESR’s and ER’s by equipping them with the multidisciplinary and complementary skills needed to not only initiate further advances in the field but to become future leaders within the field of adoptive cell therapy for cancer treatment. Such skills are global in demand making each researcher a highly desirable candidate for employment and very mobile across the different career domains.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'In Vitro Futures: an Anthropological Study of Embryo Adoption between Canada and Spain' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In Vitro Futures is a critical and innovative anthropological analysis of embryo adoption from a transnational, multi-sited and comparative perspective between Canada and Spain. The project is built around 3 fundamental, yet unanswered research questions: RQ1. From a comparative point of view, what narratives exist behind embryos adoption and how are these meanings and practices shaped or promoted by social determinants such as nationality/country, bio-political institutions, gender/sexuality, and class? RQ2. How do clinics and fertility specialists influence embryos adoption practices? RQ3. How is biological relatedness referred to by embryo donors and embryo receivers in Canada and Spain? The research aims will be reached through 3 Research Objectives (ROs), corresponding to the 3 research questions outlined above. RO1. Biomedical Issues, Moral Discourses, Salvific Logics. In the current framework of embryos adoption management RO1 will explore and study how medical actions contribute to construct a specific narrative relating to the extra embryos. RO2. To identify how these meanings and practices are coerced or promoted by social determinants such as nationality/country, bio-political institutions, gender-sexuality, class, race, in the presence or absence of a regulatory framework, this research requires the comparison between the two cases: embryo adoption in Spain and in Canada. RO3. Relatedness in Embryo Adoption Programs. RO3 will examine empirically the meanings and practices of family relatedness in the transition to parenthood of families created through this practice. My hypothesis is that the ways in which the embryos are represented and the impact of absence/presence of a law on embryo donation may have significant implications for decision-making around th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards MXenes’ biomedical applications by high-dimensional immune MAPping' (MX-MAP), addressing dissemination and exploitation.

assistant: **Impact**

The long-term goal of MX-MAP is to develop a functional pipeline for the immune characterization of new 2D nanomaterials of MXene family, for the qualitative and quantitative assessment of the human immune compatibility and immune activity towards biomedical applications.The immune characterization of the tested materials on the basis of intrinsic physical-chemical and immunological properties, through the combination of the most innovative technologies such as single-cell mass cytometry (CyTOF), will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, scaffolds for tissue engineering, cancer therapy, and antibacterial agents. MX-MAP will develop key chemistry and immune-based strategies for MXene medical applications. The implication of this project extends beyond the specific nanoscience program greatly advancing the engineering process of 2D materials and their use in biomedicine.The MX-MAP project involves fourteen key players in European and non-European countries, including the United States, Canada, Saudi Arabia, and three partners from Ukraine, coming from academia and SMEs. This program will provide strong support for the development of the careers of young brilliant scientists who want to grow towards an interdisciplinary vision of Science. Chemistry, biology, immunology, engineering, and cancer research are the expertise of MX-MAP. The senior team members are among the most influential scientists, including Prof. Yury Gogotsi (H-index=168) - inventor of MXenes, Prof. Klaus Ley (H-index=147) - one of the most cited immunologists worldwide, and Prof. Husam N Alshareef (H-index=99).  The Consortium is perfectly balanced in terms of equal gender presence; the project Coordinator Lucia Gemma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The dynamic structure of protein domains within the cytoplasmic membrane of Escherichia coli' under Horizon Europe.

assistant: **Concept**

Membrane proteins govern how bacteria inside the human body, animals, plants, water sources or soil interact with their environment. Membrane proteins show intricate spatial organization and can be compartmentalized in the membrane, but it is unknown how they dynamically assemble and vanish from membrane domains. In this project, I aim to reveal the dynamic organization of membrane protein domains in the inner membrane of Escherichia coli. I will examine the distribution and dynamics of proteins that engage in protein domains and play crucial roles in the distribution of other proteins in the membrane. These proteins are responsible for functions like membrane protein translocation, quality control, lipid raft formation, and synthesis of the peptidoglycan scaffold. By employing live-cell super-resolution and single-molecule fluorescence imaging, I will observe the assembly, movement, and variations in size and content of protein domains within growing bacterial cells. I will investigate the impact of external conditions like heat- and osmotic stress, starvation, and antibiotics on the dynamics of membrane protein domains. This proposal addresses a fundamental gap in our understanding of the organization of proteins in bacterial membranes and thus offers insights into various processes from chemotaxis to pathogen-host interactions. The development of super-resolution fluorescence microscopy protocols for imaging membrane proteins in live bacterial cells will be a methodological achievement, enabling further advancements in the field.


**Keywords:** membrane organisation, bacterial cell envelope, membrane proteins, lipid rafts, advanced fluorescence microscopy, super-resolution microscopy, live cell imaging, diffusion, bacteria, Escherichia coli
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Coordinated Research Infrastructures Building Enduring Life-science services' in the context of a Horizon 2020 call.

assistant: **Objectives**

The social and economic challenges of ageing populations and chronic disease can only be met by translation of biomedical discoveries to new, innovative and cost effective treatments. The ESFRI Biological and Medical Research Infrastructures (BMS RI) underpin every step in this process; effectively joining scientific capabilities and shared services will transform the understanding of biological mechanisms and accelerate its translation into medical care.Biological and medical research that addresses the grand challenges of health and ageing span a broad range of scientific disciplines and user communities. The BMS RIs play a central, facilitating role in this groundbreaking research: inter-disciplinary biomedical and translational research requires resources from multiple research infrastructures such as biobank samples, and resources from multiple research infrastructures such as biobank samples, imaging facilities, molecular screening centres or animal models. Through a user-led approach CORBEL will develop the tools, services and data management required by cutting-edge European research projects: collectively the BMS RIs will establish a sustained foundation of collaborative scientific services for biomedical research in Europe and embed the combined infrastructure capabilities into the scientific workflow of advanced users. Furthermore CORBEL will enable the BMS RIs to support users throughout the execution of a scientific project: from planning and grant applications through to the long-term sustainable management and exploitation of research data. By harmonising user access, unifying data management, creating common ethical and legal services, and offering joint innovation support CORBEL will establish and support a new model for biological and medical research
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Detached Eddy Simulation for Industrial Aerodynamics (DESIDER)' (DESIDER) under Sixth Framework.

assistant: **Objectives**

The proposed DESider project is motivated by the increasing demand of the European aerospace industries to improve their CFD-aided design procedure and analysis on turbulent unsteady aerodynamic flows. Recent modelling approaches such as DES, hybrid RANS-LES, embedded LES - summarised as RANS-LES methods - but also URANS have not yet reached maturity as general predictive tools for industrial CFD with a sensible" reliability.Thus the major aim is to overcome known weaknesses in the different approaches - in order to support the European aeronautics industry by providing method(s) with increased predictive accuracy for flows exhibiting separation, i.e. emphasis must be placed on the enhancement of both the modelling capability of RANS-LES methods and the alleviation of computational costs. In that respect, DESider will close the gap between RANS and LES but is not treating LES as a stand-alone method - as it is known that full LES for practical use will not be available in the next decades.The main objectives, going to be achieved by gathering expertise from European experts in the field of aerodynamics, turbulence modelling and numerical analysis up to multi-disciplinary design, are summarised as follows:- Based on the previously developed DES approach, investigate and develop advanced modelling approaches for unsteady flow simulations as a compromise between URANS and LES, which are able to produce LES- comparable results for real aeronautical applications, yet with less costly computational resources than using LES for an employment in industrial design environments.- Demonstrate capabilities of RANS-LES approaches in solving industrially relevant applications with a focus on aerodynamic flows characterised by separation, wakes, vortex interaction and buffeting, i.e.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Demanding process chains for plastics prototypes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Task 1: Basic know how and experience on infiltration techniques.Task 2: Selection of suitable silicone rubber materials.Processing system for cast polyamideBasic know how on casting of cast polyamide.Task 3: Selection of test parts, benchmark of CAD-Software packages.Simplified master mould design.Metal coatings for cast resin tools.Cast resins with improved properties, know how on optimal processing of cast resins.Improved DMLS inserts.Due to new market conditions and shorter product cycles there is a need in manufacturing industry to reduce costs and time to market. A crucial point of the development is the manufacturing of physical prototypes. Their requirements differ according to the development stage, and can be divided in the 4 broad groups design, functionality, technical testing and pre series parts. Since the end of the 1980s the application of time and cost saving Rapid Prototyping (RP) techniques has increased significantly. Today for design and first function and assembly tests such prototypes are considered to be state of the art. Nevertheless there is still a great demand on parts for technical testing, pre or even small series. Actual RP systems are not, respectively very limited, able to deliver technical prototypes with properties similar to the required series product especially if parts in high class thermoplastics like polyamide or filled plastics are required. The main objective of the project is to realise high performance technical or functional prototypes and therewith initiating new applications along three main axes: Task 1: Improvement of laser sintered parts by infiltration techniques (especially using cast polyamide) aimed to get real functional prototypes (1 5 parts). Task 2: Casting with castable polyamide into silicone rubber tools and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Communicating Vesicles' (CoVes), addressing dissemination and exploitation.

assistant: **Impact**

Networks constituted from single components able to communicate with each other in a controlled manner are at the basis of every phenomenon occurring in the world around us. Understanding and controlling information transmission processes represents one of the greatest challenges for modern scientists. I propose to develop an understanding of the working principles of complex information processing networks by using an artificial system that resembles Nature’s cell-based communication systems. Inspired by the cascade processes occurring in Nature such as the second messenger system and extracellular messenger release, “CoVes” will be based on responsive Vesicles able to Communicate in a specific and targeted manner due to different input signals. Vesicles will be equipped with a series of synthetic transducers that respond to orthogonal external chemical stimuli. Transmembrane signalling will be coupled with internal chemical messenger release leading to communication between vesicles in an information network. The working principles of the novel multi-component ensembles will be investigated leading to systems capable of transmitting information under different diffusion conditions and paving the way for novel communication mechanisms. The accurate and reliable prediction of communication processes will lead to vesicle ensembles able to store and transfer information using orthogonal stimuli which will be crucial for the development of bio-inspired nanotechnology, such as interfaces for communication with cellular systems. The accomplishments achieved through CoVes will make chemistry not only the science of matter transformation, but also the science of information storage, elaboration and transfer.


**Keywords:** Dynamic Covalent Chemistry,  Molecular Recognition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards Intelligent Cognitive AUVs' (TIC-AUV) under Horizon 2020.

assistant: **Objectives**

In recent years, long-term autonomy and persistent autonomy have ecome key areas of interest for marine robotics researchers. Ocean observatories require autonomous robot deployments over months or years. Deep-water oilfield inspection and intervention with autonomous vehicles is now a commercial reality, but fielded robots rely heavily on accurate a priori models of the subsea assets. Robustness to errors in autonomous contact tasks requires detection of execution errors.Today, our current generations of Autonomous Underwater Vehicles (AUVs) are generally limited to preplanned missions, or to limited forms of autonomy involving script switching and re-parametrisation in response to preprogrammed events.The work envisaged in this project wants to address the need of greater autonomy and capabilities, improving the cognitive and intelligent layer of marine robotics. Research activities will focus on three main interconnected areas:• semantic world representation and reasoning, in order to represent the operating environment, taking into account uncertainty at different layers (sensor data, partial view, system evolution);• intelligent active localisation techniques, in order to define a specific set of actions aiming at robot localisation in the environment;• fault management, in order to detect, classify and react to possible in-mission faults and various problems.Combining the research results in those areas and integrating them into real marine robots will result in a great increase of autonomy and intelligent cognitive capabilities, essential skills for persistent autonomy for robotics and autonomous systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Riding to extinction: epigenomics of the Ice Age horses', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The EPIRIDE project will use a combination of novel experimental and computational techniques to explore the role of epigenetics in long-term adaptive strategies of large vertebrates in response to rapid climate change. Modern and ancient horse bone samples will be analysed for epigenetic markers using advanced high-throughput sequencing approaches, and the epigenomic landscapes will be contrasted over a 30,000-year record of major climatic and environmental shifts. EPIRIDE has strong potential to reveal key genomic regions for climate adaptation in large herbivores, with considerable implications for conservation genetics and livestock management.


**Keywords:** ancient DNA,  adaptation,  horse evolution
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Mapping structural variation on native chromosomal DNA – a single molecule approach'.

assistant: **Objectives**

This proposal seeks to utilize single molecule optical detection  to directly visualize and analyze genome structural and copy number variation (SVs & CNVs) spanning up to hundreds kb of native chromosomal DNA . The project focuses on a pathogenic macro satellite repeat in the subtelomere of chromosome 4q that is linked to the third most common inherited muscular dystrophy, Facioscapulohumeral muscular dystrophy (FSHD). Specific sequences on subtelomeres are labeled with fluorescent molecules via enzymatic reactions to create a unique, chromosome specific fluorescence pattern. The DNA is then stretched in thousands of parallel nanochannels by electrophoresis and imaged on a fluorescence microscope. The resulting patterns along the DNA backbone are compared to a reference map computed from the known genome sequence and variations from the reference are classified and characterized. Specifically, we will be able to count the exact number of repeat blocks in pathogenic vs. non-pathogenic chromosomes. The immediate outcome of this project is a powerful diagnostic tool for FSHD and a proof of principle for single molecule, high throughput structural variation analysis on a genomic scale.