RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'STOrylines of futuRe extreMes' in the context of a Horizon 2020 call.

assistant: **Objectives**

Future climate projections show a strengthening of the hydrological cycle with more droughts and floods expected. This means a higher likelihood of cascading drought-to-flood disasters such as the Millennium Drought – Brisbane flooding in Australia or the California drought – Oroville spillway collapse in the US. Current research and management treat floods and droughts as independent, which leads to large underestimations of their future risk. Droughts allow ample time for impacts and adaptation, which influence hazard, exposure, and vulnerability of a subsequent flood. There are anecdotal examples of these events, but research is needed on the underlying interactions between hydrology and society. In the PerfectSTORM project (‘STOrylines of futuRe extreMes’), I propose to study drought-to-flood events to provide the understanding needed to prevent major disasters in the future. The innovative approach that I will develop is based on a combination of qualitative and quantitative storylines of past and future drought-to-flood risk in case studies and extrapolation of this rich case study information to the global scale. Qualitative storylines will be collected with narrative interviews and mental simulation workshops and will be edited and analysed. Quantitative storylines will be developed from timeseries of hydrological and social data that will be analysed and modelled. These storylines will then be combined in an iterative way using innovative data visualisation. A range of global datasets will be analysed to find global types and hotspots of drought-to-flood events and a global future 3D possibility space will be developed using socio-hydrological modelling. Positive pathways for future management of drought-to-flood events in different parts of the world will then
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modelling Individual Acoustics for plausible extended realities' under Horizon Europe.

assistant: **Concept**

The growing field of extended reality (XR) has shown how technology can expand the physical world with real-time digital information and interactions through applications spanning from hybrid meetings to assisted hearing. While plausible visual information is easily delivered, when not adapted to each user, generic sound rendering lacks realism, increases cognitive load and limits accessibility. Still, a recent study found that only 97% of analysed applications ignore personalised sound rendering due to its complex acoustic requirements.MIA (Modelling Individual Acoustics for plausible extended realities) aims at individualising audio rendering by developing a widely adoptable solution that leverages advancements in psychoacoustics and explainable artificial intelligence (AI). The proposed research effort will (1) explore and determine requirements across multiple acoustic contexts, (2) prototype an explainable AI model to infer individual audio characteristics, and (3) implement a personalisation procedure based on user actions to guarantee plausibility over specific contexts. The resulting software solution aims to provide a toolkit with minimal hardware requirements to integrate plausible audio in XR applications. MIA will foster open-science practices while exploring protection measures for EU product development, supporting the EU's goals of advancing technological innovation and enhancing digital inclusion, particularly in remote work, education, and hearing assistance technologies. To succeed, MIA integrates the diverse fields of expertise of the researcher on auditory modelling and advanced Bayesian statistics, of the host institution on audio-signal processing and XR applications, and of the secondment host on the development of explainable AI. The researcher w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Big Data and models for personalized Head and Neck Cancer Decision support' (BD2Decide) targeting Horizon 2020.

assistant: **Abstract**

Cancers of the Head and Neck Region (HNC) are the 6th more deadly cancers worldwide: in Europe ~150.000 new cases are detected and ~70.000 patients die every year. The main reasons for high mortality are the fact that the majority of cases are diagnosed in advanced Stage and the intrinsic heterogeneity of such tumors. At present the only adopted treatment decision method is based on TNM (Tumor-lymph-Nodes-Metastasis) prognostic system, that considers only a few risk factors such as smoking, alcohol abuse and more recently HPV. The TNM system is therefore inadequate to capture the patient-specific biomolecular characteristics of the tumor. HNC treatments can have hard impact on patient’s aesthetics and functionalities and, due to their toxicity, can cause severe morbidity and greatly deteriorate patient’s quality of life. A more precise prognostic prediction than the current TNM system is needed that allows implementing the first-line treatment that maximizes the therapeutic result and minimizes the impacts of therapy. BD2Decide DSS provides clinicians with the ""means"" and all the necessary information to tailor treatment and care delivery pathway to each and any HNC patient during their usual practice, in contrast to current “one-size-fits-all approach”. BD2Decide realizes and validates an Integrated Decision Support System that links  population-specific epidemiology and behavioral data, patient-specific genomic, pathology, clinical and imaging data with big data techniques, multiscale prognostic models. Advanced graphical visualization tools are developed for prognostic data disclosure and patient co-participation to the selected treatment. BD2Decide will improve the clinical decision process, uncover new patient-specific patterns that can improve care, and create a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Understanding transcriptional regulation in plant PAMP-triggered immunity' under Horizon 2020.

assistant: **Concept**

Plants are constantly exposed to a range of microbial pathogens. As plants lack an adaptive immune system, recognition and signalling in the cells directly exposed to pathogens is vital for plant defence and survival, and thus agricultural yields. Initial detection of pathogens is mediated by plant recognition of pathogen-associated molecular patterns (PAMPs), perceived by pattern recognition receptors at the plasma membrane. These receptors activate an array of signalling events, culminating in a massive transcriptional reprogramming, leading to PAMP-triggered immunity (PTI). Although this transcriptional reprogramming is vital for establishing plant defence, our knowledge of the mechanisms by which it is mediated remains fragmented. Here I propose to utilize the TRANSPLANTA collection of Arabidopsis thaliana lines that inducibly express individual transcription factors (TFs) to generate a more cohesive understanding of transcription in plant defence. Specifically, I propose to (1) identify TFs that affect PTI when overexpressed, (2) select top candidates, acting broadly in PTI regardless of pathogen, (3) elucidate their mode of regulation, using immunoblotting and protein co-immunoprecipitation, and (4) identify their target genes via chromatin immunoprecipitation-sequencing, and effect on transcription via RNA-seq. Knowledge of the identity, regulation, and targets of TFs involved in establishing PTI will allow the exploration of heretofore unknown transcriptional networks in plant immunity, providing not only insight into this signalling process but also targets for biotechnological strategies for crop protection. My graduate work on regulation of early plant stress responses has prepared me for this project, while the experience and mentorship offered by the host l
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Numerical Simulation and Design Optimization of a Lower Fuselage Structure with Advanced Integral Stiffening' (FUSDESOPT) targeting Seventh Framework.

assistant: **Abstract**

This proposal is for the structural analysis and design optimization of the lower fuselage of an aircraft. The objective of the structural optimization is minimum weight and the design constraints fall into two categories; firstly the capability to withstand structural loads with sufficient margins, and secondly constraints relating to the manufacturing methods. The structure to be optimized is a thin-walled metallic structure with stiffening elements (stringers and frames) using three options for the manufacturing technology: 1. Riveted stiffeners (conventional technology), 2. Laser welded integral stiffeners, 3. Load-adapted stiffeners with welded integral knots. The first two options are reference designs to be analyzed and compared with a new proposal based on the third manufacturing technology. Additionally, two types of aluminium alloy will be considered for the weldable options. The work shall be carried out by experienced aerospace engineers at AOES Group BV, a Dutch SME with many years specialist experience in the structural design, analysis and verification of aircraft and spacecraft structures, including FEM-simulation of large components for aircraft fuselage structures. AOES will use design optimization and topology optimization tools in NASTRAN for identifying the preliminary layout and sizing then standard stress and buckling analysis approaches for the accurate simulation of the load-bearing characteristics and detailed mass calculation. For seamless transmission of data and dissemination of results, data can be received or transmitted as engineering drawings, neutral CAD files or CATIA files. AOES also intends to use the resources of its Medialab department to provide attractive 2-D and 3-D rendering of the results of the work performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Global manufacturing in the 21st century'.

assistant: **Innovation**

Globeman21 aims to develop the framework of globally networked manufacturing in the 21st century and to promote its deployment in industry, thereby enhancing European competitiveness.The project focuses on developing generic, collaborative business models for extended enterprises in addition to addressing issues related to product life-cycle support. Particular elements of this framework will be validated and best practices identified in several industrial pilots. The complete framework will be tested by a joint demonstrator. The partners will exploit the results as they become available. The results will be disseminated widely to European industry, with a special focus on SMEs. IT vendors will be targeted for further tools development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Harmonization and improvement of rotor blade quality control' in the context of a Fourth Framework call.

assistant: **Objectives**

Objectives Efficient and well defined quality control becomes even more important in today's mass production of wind turbine rotor blades. The quality control procedures and manufacturing tolerances must be based on realistic requirements concerning the intended properties and economy of the rotor blades. Poor manufacturing quality of the blade profiles or twist distribution will affect power performance and noise emission. The project aims at identifying and avoiding such problems and will give recommendations and guidelines on the quality control of rotor blades. The project also aims at drafting improved and commonly agreed quality control procedures and measures for rotor blades which can be applied by the manufacturers as house quality procedure" under ISO 9000 and EN 45000. It is a first step towards a European Standard for rotor blade quality control. Technical Approach The project involves nine partners: Three institutes (DEWI, CRES and CIEMAT), four blade manufacturers (Abeking&Rasmussen, AERPAC, LM Glasfiber, LM Aero Construct) and two wind turbine manufacturers (AN Maschinenbau, Tacke Windtechnik). DEWI and CIEMAT will survey the applied quality control procedures and measures and investigate the changes of rotor blade properties caused by manufacturing deviations. They work out commonly agreed on and improved quality control procedures and measures. The main work of the project is done by the institutes in order to ensure that the industrial participants do not have access to the confidential information of their competitors. CRES will perform an analytic and stochastic investigation to simulate the influence of blade tolerances on the power and energy capture of a rotor. The WEC manufacturers AN Maschinenbau and Tacke Windtechnik will provide information on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'African Vector Control:  New Tools' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The AvecNet consortium will develop practical solutions to the current limitations of vector control strategies in Africa using a combination of translationally-aware, state of the art science and end user analysis to ensure successful development and uptake of the new and improved approaches to malaria control and elimination.  Our carefully balanced, multidisciplinary team of European and African experts includes vector biologists, engineers, epidemiologists, social scientists and leaders of large supranational consortia.  These partners are all prominent members of global vector control research programs having unique specialization in Africa-centric projects.Together we have developed a proposal focused specifically to address the three major research challenges that confront efforts to interrupt mosquito-mediated transmission of malaria in Africa:1. The need for practical strategies to prolong the efficacy of existing insecticide-based vector control methods,2.The need to develop new interventions that target all major malaria vectors, that are simultaneously effective, socially acceptable and sustainable,3. The impact of the major demographic and environmental changes occurring in Africa on malaria epidemiology and control.These research activities are cross-linked by specific tasks to reinforce our commitment to ensure sustainability, engage all stakeholders and strengthen research capacity in Africa.Overall, the project will add significant value to the international research effort in vector control by taking forward the state of the art and translating this into new or improved control tools that will be trialled within the time frame of this project. The studies planned in this collaborative project will provide scalable solutions, giving the solid platform u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polymeric membranes with tunable nanochannels for the electrodeposition of metal nanowires' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The project comprises two main objectives:(a) evaluation of the different techniques which permit the preparation of polymeric membranes with tunable nanochannels and improvement of those providing the higher level of structure control, in relation with their application(b) for the template synthesis of nanometals. The first objective will be persecuted by using methods that include a process of selective removal of part of a complex polymeric micro-phased structure. Both already proposed methods, such us those based on the selective degradation of polisoprene in polystyrene-block-polyisoprene and on the selective hydrolysis of poly(tert-butyl acrilate) in poly (tert-butyl acrilate) -block-poly (2-cinnamoylethyl methacrylate), and also novel techniques based on the selective degradation of polymer blends will be tested for the achievement of membranes with tunable nanochannels. Furthermore, the most promising of the polymeric membranes, in terms of both tunability of nanochannel size and their distribution, and easiness of experimental preparation, will be used for the template synthesis of metal nanowires. The evaluation of the properties, and in particular the technologically interesting magnetic properties, of such nanowires will furnish information for further preparation of membranes, in order to reach a tailoring of the structure of the polymeric skin layer in consideration of the properties claimed" by the metal nanowires. The host group has a proved experience in both inorganic and polymeric systems and will provide the basic knowledge on polymeric membranes and a strong background on preparation of nanostructured materials, which will allow the candidate to be in contact with the front-line of the research in this field. The period of fellowship will also give
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multilayers for magnetooptical ultrahigh density recording' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Next generations of magnetic recording will use bit sizes well below one Um (Ultrahigh Density Recording"). Recently, Betzig et al. (Appl. Phys. Lett. 61, 142(1992)) showed that bits as small as 60nm in diameter could be recorded in Co/Pt multilayers, using a Magneto-Optical Scanning Near field Optical Microscope (MO-SNOM). The work proposed here will bear on this subject. (Pt/F) alloys and multilayers with F= Co, Fe, CoNi, etc..., will be grown using a multitarget sputtering unit on different amorphous or crystalline substrate structures. Samples will be characterized either with conventional means: X ray diffraction, TEM, STM/AFM, magnetometry, magnetooptical Kerr spectroscopy, or using a MO-SNOM currently being developed on the basis of an already operating SNOM with 20nm resolution. Interface and structural properties will be optimized to get perpendicular magnetization, enhanced magnetooptical effects, and a micromagnetic behaviour adapted to the writing of "nano"-bits with minimum wall jaggedness. "
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Phylogenomic-driven Drug Discovery from Rhodococcus and Saccharomonospora using 2D and 3D Cell Cultures' to be submitted under Horizon Europe.

assistant: **Abstract**

The project titled, 'Phylogenomic-driven Drug Discovery from Rhodococcus and Saccharomonospora using 2D and 3D Cell Cultures' aims to explore the microbial diversity and genomic landscape of two important, yet somewhat neglected, natural product producing actinobacterial genera, Rhodococcus and Saccharomonospora. Symbiotic systems and unique habitats will serve as isolation sources of novel species, and I will employ state-of-the-art sequencing techniques to perform a comprehensive in depth phylogenomic analysis to fully depict their biocatalytic repertoire and by doing so, unravel their unique natural product potential. I will spearhead the establishment of novel 2D and 3D cultivation techniques with ecomimetic properties to mimic natural scenarios and thereby trigger the production of cryptic metabolites. I will employ sophisticated dereplication and chemical analytical strategies to characterize and structurally elucidate novel chemical entities with drug-like scaffolds. Based on these results, I will be able to test all of the identified natural products for their pharmacological properties within the framework of the Helmholtz drug discovery pipeline and collaboration partners. My targeted and interdisciplinary research approach will allow me to gain valuable genomic and evolutionary insights and streamline the discovery of pharmaceutically valuable natural product scaffolds.


**Keywords:** Natural product discovery,  secondary metabolites,  antimicrobial activity