RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Mechanism and vulnerability of BAP1 loss in tumor metastasis' (VulneraBAP1) under Horizon 2020.

assistant: **Objectives**

Kidney cancer is among the ten most prevalent cancers arising in Western countries, with clear-cell renal cell carcinoma (ccRCC) being the most frequent subtype (75%). About 30% of ccRCC patients present with metastatic disease at diagnosis, and another 30% will develop metastases after surgery. When metastatic, ccRCC remains largely incurable. I recently discovered that the tumor suppressor BAP1 (BRCA1-associated protein 1) is inactivated in 15% of ccRCCs (Peña-Llopis et al. Nat. Genet. 2012). Notably, I found that mutations in BAP1 are mutually exclusive with mutations of the tumor suppressor gene PBRM1, and loss of BAP1 was associated with higher tumor grade, activation of mTORC1, and poorer overall patient survival, whereas tumors with PBRM1 loss were associated with lower tumor grade and better overall survival. This first molecular genetic classification of ccRCC may have tangible clinical implications, since tumors with BAP1 loss display in general more aggressive pathological features and are more prone to metastasize. However, the molecular mechanism through which BAP1 loss induces metastasis and tumor aggressiveness remains elusive. In this study, I aim to investigate the molecular mechanism of repression of a miRNA cluster involved in metastasis by BAP1 and identify therapeutic opportunities. Specifically, I will (1) supervise a PhD student (supported by a grant I was recently been awarded) in the identification and characterization of the BAP1 protein complex that binds at the miRNA cluster promoter; and (2) I will uncover the genetic vulnerabilities of BAP1 loss by a synthetic lethality strategy. These studies will facilitate attainment of my long term career goal to become a group leader and a fully independent investigator.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Atmospheric flux-measurements of precursor-gases for air-quality and climate research' under Seventh Framework.

assistant: **Concept**

Observational capabilities are a critical component for advancing surface-atmosphere interactions science. This includes state-of-the-art capabilities for analyzing trace gas fluxes in support of the wider Earth science research community as well as the development of cutting edge technology that will lead the community toward a new generation of analytical capabilities needed to improve Earth system models. Here it is proposed to develop a comprehensive research program allowing the investigation of the exchange of reactive (volatile organic compounds (VOC), NOx, O3, CO, CH4) and non-reactive (H2O, CO2) trace constituents at the surface-atmosphere interface based on novel time-of-flight mass spectrometry coupled to chemical ionization. Methods developed and tested within this project have the potential to lead to a long-term research program at the host organization aimed at the development of comprehensive instrumentation for eddy covariance measurements of reactive trace gases and aerosols and their application to atmospheric research. The proposed research activity will therefore provide new tools to the environmental monitoring community (e.g. the fluxnet communities such as CarboEurope or NitroEurope). Eddy flux systems developed and tested within this project will be evaluated at a newly established research flux site (i-BOX) at the host organization, targeting the investigation of trace gas exchange processes in orographically complex terrain in an Alpine valley, which is also subject to intense air pollution problems. Technology proposed within this project will ultimately provide critical data aiding in developing cost-effective control strategies and shed light on potential synergistic and antagonistic effects between air pollution and climate change regulati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Bilingualism and brain plasticity: a multidisciplinary adaptive workshop' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

We propose to organize a 3-day workshop that will bring to Trieste 18 top experts in a diversity of allied fields, to discuss bilingualism and brain plasticity. It will also discuss second language acquisition in different conditions (during puberty, after puberty) of both signed and spoken language. The main research goals are to determine to what extent the age of acquisition of language influences the performance of speakers, in which areas of language these influences are more evident (phonology, morphology, syntax), how intensive training bears on the speakers' performance and what brain imaging studies can reveal about the organization and functioning of the language capacity. A parallel goal is the multidisciplinary advanced training of an equal number of younger researchers, who will be selected to participate in the workshop, while additional provisions have been made for the wider dissemination of its results.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Doctoral training in theoretical and applied nonlinear systems at surrey'.

assistant: **Concept**

The University of Surrey School of Electronics, Computing and Mathematics Doctoral Training in Theoretical and Applied Nonlinear Systems Applications are invited for approximately12 Marie-Curie PhD Training Fellowships to be held within the Mathematics Research Group during the period 2002-2005. Candidates must be registered for a PhD or similar research degree at a university in the European Union (excluding the UK) or an Associated State. Fellowships will enable them to visit Surrey to work with members of the Group for periods of 3- 12 months on topics of mutual interest. The research of the Group focuses particularly on applications of analysis, geometry, ergodic theory and symmetry methods to finite and infinite dimensional systems (general and Hamiltonian), and on applications of nonlinear systems theory to problems from physics, chemistry, biology and engineering. Examples include fluid flows, sand rippling, electric circuits, molecular dynamics and spectra, astrodynamics, and the modeling and analysis of biological and bio- fluid systems. Further information on the Group and its research can be found at: http://vww.maths.surrev.ac.uk/. Applications and informal enquiries should be sent to the coordinator Prof. Mark Roberts. Department of Mathematics and Statistics, University of Surrey, Guildford. Surrey, GU2 7XH, United Kingdom. E-mail: M.Roberts@surrey.ac.uk Potential applicants are strongly encouraged to contact the coordinator or any other member of the Group to discuss their application before submitting it, and at least 4 months before the proposed visit. The University is committed to an equal opportunities policy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'New approach to innovative technologies in manufacturing'.

assistant: **Concept**

At the dawn of 21st century the importance of economy being up to date with the latest scientific developments – such as Industry 4.0 - is more evident than ever before. Recent global situation has proven that in order for the principles of I4.0 to be successfully implemented, the industry must cooperate closely with universities and authorities. In Poland this cooperation is still insufficient and to solve this problem GDAŃSK TECH teams up with KTH Stockholm, TU Berlin and NTU Athens. The overall objective of the NEPTUN Project is to raise the GDAŃSK TECH level of excellence in the area of additive manufacturing accompanied by cloud computing and control, virtual reality modelling and simulation technology. The project will allow GDAŃSK TECH to become a leading entity in the research and innovation not only on a regional but on a national level, making it an efficient partner in developing Industry 4.0 in Poland. The partners' experience and expertise with research and innovation activities in such fields as applying DMLS/SML, SLS and FDM for prototyping with incorporating the process and parameter optimization and control of 3D printed materials for functional use, modelling robotic cells in VR environment or applying evolutionary algorithms in manufacturing will allow GDAŃSK TECH to expand its expertise and to engage in R&D&I activities on a whole new level. An important aspect of the project is a work package connected with exploratory research project related to fabrication and design of new mechanical metamaterials – artificial structures whose mechanical properties are defined not only by their composition but also by their structure. Other WPs will boost the development of Industry 4.0 on the regional and national level by forming NEPTUN Cluster of Excellence. N
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Precise optical synchronization of high-speed electronics with microcombs' under Horizon Europe.

assistant: **Concept**

Laser frequency combs based on mode-locked lasers are extraordinary photonic devices that have revolutionized precision frequency synthesis and metrology in the 21st century. They have enabled groundbreaking developments such as optical clocks, femtosecond-level timing synchronization, and ultra-pure microwave generation.Microresonator-based frequency combs (microcombs) offer a transformative potential to reduce the complexity and size of traditional laser frequency combs. Recent advances in dissipative Kerr solitons have demonstrated the viability of these chip-scale devices, which can be manufactured at the wafer level through semiconductor processing techniques. However, microcombs still fall short in stability and phase noise compared to their non-integrated, mode-locked counterparts due to intrinsic scaling limitations when operating at the chip scale.This proposal seeks to bridge this performance gap by developing high-performance, octave-spanning microcombs with photodetectable repetition rates using innovative arrangements of coupled microresonators. These advancements will enable single-point optical frequency division, whereby the comb’s degrees of freedom will be determined by an optical frequency reference. The project will explore 3D integration of ultralow-loss silicon nitride with advanced materials, aiming to create high-performance microcomb-based systems on a chip, and lay the foundation for novel optoelectronic synchronization architectures in datacenters.These innovations address key challenges in energy consumption and capacity scaling in datacenters and large scaling computing architectures, paving the way for future advancements in global communication infrastructure.


**Keywords:** silicon photonics; laser frequency combs; fiber-optic communicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Revolutionizing Stationary Energy Storage Cost: Go To Market Plan For Zinc-Ion Rechargeable Batteries'.

assistant: **Concept**

The current global market for Stationary Energy Storage will reach roughly $ 26 billion by 2022, at a compound annual growth rate (CAGR) of 46.5 %, mostly fuelled by the rapid growth of Renewable Energy Sources (RES). Due to their intrinsic intermittence, RES are dependent on large-scale energy storage technologies to definitely to reach higher levels of cost-efficiency. However, significant challenges remain when it comes to reaching the low-cost levels at which storage technologies combined with RES become competitive with the traditional electrical grid, while also remaining environmentally friendly. Enerpoly’s Zinc-Ion battery cell technology represents a breakthrough in stationary storage, by offering a simple, environmentally friendly, efficient, durable and low-cost alternative to Lead-Acid and Lithium-Ion batteries, today’s most used storage technologies. Besides storing renewable energy, Enerpoly’s technology can be used in many Uninterrupted Power Supply (UPS) applications at grid, industrial, commercial and even residential levels such as peak saving, datacentres, telco equipment, commercial and residential storage. ENERZ, Enerpoly’s main product, will allow battery manufacturers to reduce their current costs in more than 80% for the same kWh storage capacity when compared to Lead-Acid and Lithium-Ion batteries, with a longer cycle life and better safety. Thanks to this project, we expect to validate our prototype and consequently deploy our first pilot production line. We aim to reach €11,2 million turnover in 2025, four years after market entry, generating 25 positions in Sweden and helping positioning Europe at the forefront of energy storage technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Perineuronal net treatments for neurodegenerative disease' (ECMneuro).

assistant: **Innovation**

Inhibitory chondroitin sulphate proteoglycans (CSPGs) have several roles in CNS damage and repair, revealed by their digestion with chondroitinase. Most recently, digestion of CSPGs in the limbic system and cortex has led to a very substantial enhancement of memory.The effects of CSPGs on plasticity and memory are largely through their concentration into PNNs, because transgenics lacking the PNN component link protein in the CNS have very attenuated PNNs, and show continuing plasticity into adulthood, and enhanced memory in just the same way as chondroitinase-treated animals. The PNN is therefore a novel therapeutic target that has not been explored.This application focuses particularly on enhancement of memory through manipulation of PNNs.In Alzheimer’s disease (AD) and ageing the main cognitive disability is loss of memory. The enhancement of memory following chondroitinase treatment or PNN knockout in object memory is many times greater than obtained using cholinesterase inhibitors (the only currently available treatment for memory enhancement). PNN manipulation is therefore a particularly promising avenue for developing treatments to overcome the main cognitive disability of AD and ageing.The aims of the application are:1. Test the extent of memory enhancement due to PNN manipulation in models of AD due to Abeta, tau mutations and in aged CNS.2. Establish the molecular mechanism for PNN effects on memory, focusing on Semaphorin3 presentation by PNNs, and direct effects via the PTPsigma receptor.3. Discover the sulphation modifications of the CSPG glycan chains that enable binding of Semaphorin3s, activation of the PTPsigma receptor.4. Analyse molecules that bind to PNN glycans, to identify new potential effectors of PNN effects on memory and plasticity5. Testing in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Green BACTERIAL PHOTOSYNTHESIS : STRUCTURE FUNCTION AND REGULATION OF LIGHT-HARVESTING SYSTEMS AND CORE-COMPLEXES'.

assistant: **Concept**

The proposal concerns the antenna and core complexes of green on groups with active research programmes, as is the case with all the photosynthetic bacteria. The antenna systems of these bacteria are exceptional in their variation and complexity, but they share one common, participating groups. In addition, they should have easy access to advanced research equipment and facilities, and be allowed to exploit this major component, the chlorosomes, oblong bodies, attached to the cytoplasmic membrane. The membrane contains the core complex and the potential for their own research project. Both aspects are strongly reaction center. represented in the proposed network, and the scientific horizon of the The core complex contains bacteriochlorophyll (BCh1) a, whereas the young researchers may be further expanded by the interdisciplinary nature chlorosomes contain a set of homologues of BCh1 c, d and e which have a of this network.  The young researchers will further be encouraged to actively participate strong tendency to form aggregates. There is strong evidence that such aggregates are actually present in chlorosomes. in group meetings and discussions, seminar programs of participating The chlorosomes are typical examples of systems in which energy transfer groups and research institutions, international conferences, summer is governed by strong dipolar interactions, and one question which will be schools and courses, and to assist in the periodic evaluation of the addressed by various advanced spectroscopic methods concerns the actual project. All these activities are considered to be essential for their mechanism of energy transfer and excited state dynamics in chlorosomes as scientific development, and an adequate part of the budget is reserved for this purpose. well as in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ISOS-Implantable Ecosystems of Genetically Modified Bacteria for the Personalized Treatment of Patients with Chronic Diseases' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In ISOS we propose to develop the first biomedical product for the in-situ fabrication and auto-renewed delivery of therapeutic compounds employing complex ecosystems of probiotic genetically engineered bacteria (GEB) integrated in a biomaterial-based bioreactor. ISOS is designed to treat chronic diseases requiring lengthy treatments. The encapsulated GEB populations produce the therapeutic molecules ""on demand"", stimulated by the signals of the pathological environment within the patient, i.e., inflammation and/or reactive oxygen species. Bacteria populations interact among them to maintain a dynamic equilibrium of the GEB species and to guarantee the survival of the drug-producing GEB as long as the disease persists. The GEB ecosystem is designed in such a way that bacteria cannot survive outside of the encapsulating biomaterial, to meet future biosafety and regulatory requirements. The design and the configuration of the GEB ecosystem will be personalized for each patient, and it will be done using in-silico tools and synthetic biology.As a Proof-of-Concept, we propose to engineer an implantable GEB-based bioreactor for the therapy of the wet form of age-related macular degeneration (wAMD), which is caused by an abnormal production of Vascular Endothelial Growth factor (VEGF). This Proof-of-Concept will demonstrate the ability of ISOS to replace the repeated intraocular injections of Anti-VEGF molecules (current treatment) with a single ISOS bioreactor that will enhance the therapeutic response and minimize side effects due the molecular crosstalk between ISOS and the pathological environment. ISOS will establish the principles of a new generation of therapeutic products that will use recombinant probiotic bacteria strains libraries for personalized treatments with