RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Real-time tracking of single membrane translocases' to be submitted under Seventh Framework.

assistant: **Abstract**

The threading of proteins through narrow channels within a cell is a crucial biological process, which is essential for cellular protein trafficking and protein degradation. This translocation process is also used by pathogens such as anthrax and C. Difficile, which inject their lethal toxins through the cell membrane in order to hijack vital cell machinery.  The motor proteins driving this translocation process are called protein translocases. Despite the ubiquity of protein translocation in biology, the underlying mechanisms remain poorly understood. Improving our knowledge of translocation will have implications on our understanding of severe pathologies, which have been linked to the dysfunction of translocases (e.g., cancers, Alzheimer’s).I intend to design novel biorelevant in vitro tools to investigate the inner workings of membrane-associated protein translocases. The translocase will be reconstituted in a cell-like microenvironment, while allowing real time control over biologically appropriate external conditions that may affect its function in vivo (e.g., voltage/pH gradient across membrane). Our innovative approach is based on the integration of novel lipid systems into a combination of optical tweezers and electrophysiology techniques. The first translocase targeted is FtsH, whose role is to dislocate proteins from membranes. We will directly measure the translocation velocity and step size of this membrane-associated translocase with unprecedented detail, while being able to control the protonmotive force.These new assays will advance considerably single-molecule investigations of membrane proteins, which represent 30% of all proteins and are prime drug targets. This work will lay foundations towards elucidating the mechanisms behind other crucial membrane
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Accelerating the discovery of high-performance electrocatalysts through artificial intelligence and robotics technology' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Catalysts are fundamental for almost all industry products as they accelerate and control the selectivity of chemical reactions. As such, they play a crucial role in mitigating the climate crisis to transition away from fossil fuels by utilizing CO2 in electrochemical reactions to synthetize carbon neutral end products. However, catalyst innovation is lacking. It takes about 20 years to discover a new catalyst with multi-million euros R&D expenses. To enable a carbon neutral industry in the near future, Dunia is revolutionizing electrocatalyst discovery with its autonomous, artificial-intelligence- and robotic- driven laboratory. This breakthrough technology significantly accelerates the discovery process, reducing timeframes by up to 90% and cutting costs by at least 60-70% compared to conventional methods, while building the largest and most reliable database for future electrocatalyst research. As a result, Dunia is able to find high-performance catalysts that can utilize captured CO2 in the production of value-added chemicals and green fuels.


**Keywords:** Catalysis, electrocatalyst, eMAP, autonomous laboratory, artificial intelligence, machine learning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Instrument design and control of plastic processing moulds by heat flow measurement' to be submitted under Fifth Framework.

assistant: **Abstract**

The research proposal concerns the application of heat flow measurement to instrument design and control of plastic processing moulds. It will optimise manufacturing conditions by driving the processes by the matter's state-dependent rheological parameters (understanding and characterization of the physical phenomena involved).Large plastic parts;- especially those for cars are currently manufactured by sequential injection with empirical control of the following three points:- mould filling;- shrinking due to cooling (monitoring of compacting and maintenance pressures);- The plastic's crystallization threshold before extraction.The expected outcomes of this research for industry are a >20% improvement in production rates, noticeably less waste, and above all the improved physical quality of the final products.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'European Network for Genetic-Epidemiological Studies: building a method to dissect complex genetic traits, using essential hypertension as a disease model' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The project is focused on the definition of a comprehensive genetic epidemiological model of complex traits like Essential Hypertension (EH) and intermediate phenotypes of hypertension dependent/associated Target Organ Damages (TOD). To identify the common genetic variants relevant for the pathogenesis of EH and TODs, we will perform a Whole Genome Association (WGA) study of 4.000 subjects recruited from historical well-characterized European cohorts. Genotyping will be done with the Illumina Human 1M BeadChip. Well-established multi-variate techniques and innovative genomic analyses through machine learning techniques will be used for the WGA investigations. Using machine learning approach we aim at developing a disease model of EH integrating the available information on EH and TOD with relevant validated pathways and genetic/environmental information to mimic the clinician's recognition pattern of EH/TOD and their causes in an individual patient. Our statistical design is with two samples run in parallel, each with 1,000 cases and 1,000 controls, followed by a replication/joint analysis. This design is more powerful than replication alone and allows also a formal testing of the potential heterogeneity of findings compared to a single step (one large sample) design. The results represent the source to build a customized and inexpensive genetic diagnostic chip that can be validated in our existing cohorts (n=12,000 subjects). HYPERGENES is in the unique position to propose a ground-breaking project, improving the methodology of genetic epidemiology of chronic complex diseases that have a high prevalence among EU populations. Designing a comprehensive genetic epidemiological model of complex traits will also help us to translate genetic findings into improved diagnostic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The mutation-buffering capacity of RNA chaperones' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The goal of this project is to investigate how mutations that affect RNA structure can be buffered in trans by RNA chaperones using a combination of experimental and computational approaches. The Warnecke lab (the host) recently showed that RNA chaperones, like their protein chaperone counterparts, can buffer the fitness effects of deleterious mutations in Escherichia coli (Rudan et al. 2015 eLife, 4:e04745). However, the rules governing mutation buffering at the RNA level remain poorly understood. Do RNA chaperones rescue misfolded RNA intermediates? Do they alleviate the effects of mutation that lead to excessively stable secondary structures? Which mutations are amenable to buffering and which are not? And does that presence of RNA chaperones render their substrate RNAs more evolvable? Here, I will evaluate the buffering capacity of a model RNA chaperone, the DEAD-box RNA helicase CYT-19, by exploring how it affects the mutational robustness of the Tetrahymena group I intron, whose self-splicing activity is dependent on its structure. Following systematic site-directed and random mutagenesis, I will assay differential splicing activity of the generated intron variants and compare results to predictions from RNA structural modelling. Importantly, I will assay activity both in the presence and in the absence of CYT-19 to identify mutations that are buffered by RNA chaperone activity. To further understand the structural impact of chaperone-dependent mutations, I will use in-cell SHAPE-Seq to determine the mutated intron structures. To my knowledge, this is the first quantitative assessment of mutational effects on RNA in the presence of an RNA chaperone. The expected outcome will improve our understanding of RNA robustness, and may reveal insights into making better RN
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The Role of Green Quantitative Easing for Optimal Climate Change Policies'.

assistant: **Concept**

The United Nations Sustainable Development Goal 13 calls to ""Take urgent action to combat climate change and its impacts"" by 2030. This call to take action also reached central banks: A controversial debate of whether monetary policy shall target climate change mitigation is ongoing. This addresses also the use of titling the asset purchase programs towards green assets (green quantitative easing, green QE). GREENQE contributes to this discussion, by investigating how large of a carbon emission and temperature reduction could be achieved by tilting the corporate asset portfolio of central banks around the world towards green assets. Benefits from slowing down climate change are contrasted with costs from possible impediments to the monetary transmission channels. These costs and benefits are quantified using a rich integrated assessment model with incomplete markets and aggregate risk, featuring a green and brown sector of production, asset markets and fiscal and monetary authorities. This allows to evaluate the trade-offs of greening central banks' asset purchases (climate change mitigation vs. impeding monetary transmission mechanisms) as well as to investigate whether a monetary policy focused on the business cycle horizon can be used effectively to address a slow-moving climate change process.The results of GREENQE are of interest to various stakeholders, including foremost central banks as well as governments. If green QE is found to be an effective and not-costly tool it might be used to complement green fiscal policies of national governments and supranationals like the EU commission.""


**Keywords:** Climate Change,  Monetary Policy,  Green Quantitative Easing,  Carbon Taxation,  Integrated Assessment Model
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Adaptive and innovative Radiation Treatment FOR improving Cancer patients treatment outcomE' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Loco-regional treatment is the mainstay of cancer cures in non small lung and head and neck cancer. For advanced stage cancer, dose intense multimodality treatment is required yet affected by substantial side effects. Our aim is to improve treatment outcome in locally advanced head and neck and lung cancer patients by:1. Optimizing local control by introducing novel radiation techniques resulting in redistribution of the radiation dose, creating inhomogeneous dose distribution towards the most active part of the tumour instead of conventional homogenous doses. This redistribution can be performed without increase of toxicity. As recently reported radiation accidents in the US demonstrate, QA is of outmost importance for safe radiation delivery in complex treatments. To assure accurate delivery over time, we will monitor both the patient’s geometry as well as the delivered dose using image guided adaptive plan modifications and 3D in-vivo dosimetric verification.2. Maximizing the benefit of combined modality treatmentBoth cisplatin and Cetuximab in combination with radiotherapy have shown to improve local control and survival but both drugs have severe side effects. As these drugs are not active in all patients, there is a large need to select patients which are sensitive to either drug. For this purpose the uptake of Cetuximab will be estimated by imaging tumour uptake with Zr89 labelled Cetuximab, while cisplatin sensitive tumours can be selected by biomarkers. This part was stopped in May 2014.This proposal will:1optimise efficiency by selecting patients on treatment specific tumour response predictors and tailoring radiation to most active parts of the tumour.2improve quality of life by withholding ineffective, toxic treatments and redistribution of dose.3decrease co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transgenic mice as innovative system for the screening and the pharmacokinetic analysis of new molecules active trough nuclear receptors' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

It is proposed to integrate the screening phases of drug acting on nuclear receptors by generating mice that bear a hormonally responsive transgene which expression is regulated by estrogens or progestagens. The mice will be utilized for the combined secondary and tertiary screening of synthetic molecules acing on progesterone and/or estrogen receptor.Synthetic ligands for female sex steroid receptors represent a widely employed class of drugs of ever growing importance in the fertility control and for the therapy of a large variety of pathologies (neoplasia, osteoporosis, endometriosis, premenstrual tension). It has been calculated that in industrialized countries more than one third of the total female population will be prescribed to take sex steroid hormones for about 30-40 years of their life. The side effects of these treatments (increased risk of uterine and breast cancer, increased risk of cardiovascular accidents, osteoporosis, degenerative diseases of the nervous system, etc.) have been a major source of discussion since the commercialisation of the first birth control pill. The undesired effects are linked to a) the widespread distribution of the intracellular receptors and b) the lack of tissue-specific activity displayed by synthetic agonists and antagonists of estrogen and progesterone receptor.In additions, recent studies revealed the existence of mechanisms of cross-coupling between membrane receptors and intracellular receptors, further augmenting the possibility of undesired effects linked to the activation of intracellular receptors. Well aware of the difficulties in designing molecules endowed with tissue specificity, we proposed in BRIDGE (t-Project Animal Cell Biotechnology Programme, BIOT CT920308) to establish a series of cell lines of various or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Restoring tissue regeneration in patients with visceral Graft versus Host Disease.' (RETHRIM).

assistant: **Innovation**

Stem cell regenerative therapies hold great promise for patients suffering from a variety of disorders that are associated with tissue or organ injury. Regeneration relies on tissue or organ-specific stem and progenitor cells, but can also aim at promoting the endogenous repair capacity of the body. Mesenchymal stromal cells (MSC) are undergoing clinical testing in a variety of clinical conditions aiming at repair through direct or indirect mechanisms. Their ability to form bone or cartilage is used to directly repair these tissues. In other conditions their regenerative effects are based on endogenous repair through their anti-inflammatory properties. The latter mechanism is important in the treatment of acute Graft-versus-Host Disease (GvHD). We have been involved in the clinical development from the beginning and we have shown the therapeutic potential. However, no results of controlled randomized phase 3 studies have been published to date, thereby hampering safety and efficacy assessment. Within our consortium we have developed an academic infrastructure for the harmonized production of MSC. In the RETHRIM proposal this will be combined with our clinical expertise to conduct the first Europe-wide placebo controlled randomized phase III trial using MSC regenerative therapy for the treatment of steroid-resistant visceral GvHD. Central to the RETHRIM project is the clinical trial for which 150 patients will be recruited. All MSC products will be extensively analysed using molecular and functional markers, in order to develop a potency signature for the product and for the prediction of response. We also intend to collect data from additional quality of life, health technology assessment and ethical studies. We will apply for an Orphan Drug Designation in Europe and th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New drug delivery systems using hydrophobically modified polymers' (HYDROPOL), addressing dissemination and exploitation.

assistant: **Impact**

The project will focus on the development of hydrophobically modified polymers (polysaccharides) and their application as functional materials in controlled drug delivery.On carefully characterized biopolymers such as pectin, chitosan and alginate, and their hydrophobically modified analogues, solution and gelation properties will be examined by different experimental techniques with the purpose of establishing their potential as carriers in drug release processes.The interaction between mixed polymers, such as alginate and the biologically important mucin molecule will also be addressed. Polymers to be used in tailor-made formulations must be characterized in relation to their interaction with endogen substances, enzymes as well as the type of tissue the y will be exposed to in a considered formulation.To gain insight into this matter, it is necessary to survey the interaction between drugs and the polymer matrix. Furthermore, to investigate the potential of these polymers in pharmaceutical formulations, it is important to study properties such as the rate of swelling of the polymer gels, the degree of penetration of drug substances through the gel matrix and interaction of the drug with the polymer at different conditions.Finally, the effect of hydrophobic modification on release, degradability by colonic enzymes and bioadhesiveness will be evaluated. Among the experimental techniques that will be employed in this study are rheology, turbidimetry, small-angle neutron scattering, as well as intensity and dynamic light scattering.In this project, simulations and theoretical calculations will constitute an additional tool in the understanding of the new polymer-based drug delivery systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Ultra High Aspect Ratio Wing Advanced Research and Designs'.

assistant: **Innovation**

U-HARWARD will consider the use of innovative aerodynamic and aeroelastic designs in a multi-fidelity multi-disciplinary optimal design approach to facilitate the development of Ultra-High aspect ratio wings for large transport aircraft. A conceptual design study, building on the current state of the art, will perform trade-off studies to determine the potential gains of different wing configurations and loads alleviation concepts in terms of aerodynamics, weight, noise, fuel-burn and range. Scaled model wind tunnel tests will be used to validate parametric variations in the aerodynamic and acoustic characteristics. Starting from a reference aircraft, the preliminary design of the best candidate configuration will be completed and the estimated gains validated using high fidelity tools and a larger scale aeroelastic test.


**Keywords:** High aspect ratio wing, Multidisciplinary design optimization, Aeroelastic testing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deployment of interurban ATT test scenarios' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

- Identification of options currently available and likely to become available in the short and medium term for implementing co-operative driving", based upon ATT systems for motorway type roads.- Development of scenarios of "highest potential impcat" %"