RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Steroids, neurodegeneration and immuno senescence'.

assistant: **Concept**

Degeneration of the nervous and immune systems, both in normal ageing and in conditions such as Alzheimer's disease (AD), has been attributed to the lifetime decline in circulating levels of the adrenal steroid debydroepiandrosterone (DHEA). In humans and higher primates, levels of DHEA fall dramatically with age. Because DHEA improves hippocampus-associated learning and memory in rodents, and markedly improves perceived well-being in middle-aged volunteers, a causal link between falling DHEA levels and age-related cognitive decline including AD has been discussed. Further, DHEA administration clearly improves immune responsiveness of ageing rodents. For these reasons DHEA has been widely and publicly advocated in the therapy of age-related disorders including memory impairment. However, the mechanism of action of DHEA is unknown. A plausible hypothesis is that DHEA antagonizes glucocorticoid action, because excess glucocorticoids attenuate memory function and promote neurotoxicity in the hippocampus, while having clear immunosuppressive effects. However, DHEA fails to interact with glucocorticoid receptors. We have previously reported that DHEA and related steroids are selectively metabolized, in brain and other tissues, to modified molecules, predominantly 7a-hydroxy derivatives but including 6 and 7beta-modified derivatives. For many years the enzyme(s) responsible were unknown, but recently we reported the molecular characterization of a novel cytochrome P450 from rodent brain, Cyp7b, that efficiently converts DHEA to 7ahydroxy DHEA (7HD). Further, we have shown that 7HD, unlike its precursor DHEA, is an antagonist of the glucocorticoid response. Moreover, CYP7B mRNA levels are selectively reduced in Alzheimer's disease. We surmise that excess glucocorticoid action
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A novel approch to thermal anticorrosion protection' to be submitted under Fifth Framework.

assistant: **Abstract**

Thermal corrosion is a common phenomenon widely present elsewhere and in particular in systems with elevated temperatures. Annual losses from thermal corrosion amount to 200.000.000 EURO annually. Typically the thermal anticorrosion protection involves expensive materials and rather cumbersome technologies. The proposed work is directed towards improvement of anticorrosion technologies making it toxic-free, low-cost and highly reliable. This will lead not to only better protection of metallic substrates but a possible wide use in related industries where due to high temperatures metals are most vulnerable. The technology is based on the fabrication of nanocrystalline ceramic materials and a Laser direct densification/fabrication technology that was never available before. The technology will be rigorously tested and the SMEs employees will become familiar with its use. About 1.5 years are needed to reach the market after the completion of STEP 2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scientific Top Training in Antimicrobial Research' (2014-2020).

assistant: **Concept**

The Amsterdam Institute for Molecules, Medicines and Systems (AIMMS, www.aimms.vu.nl) offers an innovative selectionprocedure for international Top Master's Students to train a new generation of top scientists who can contribute to solvingthe problem of bacterial, viral and parasitic diseases.A multitude of microbes, and their resistance in particular, threaten the health of European citizens and the communityworldwide. For 'attacking' the bugs involved, we need new multidisciplinary approaches and strategies, includingtranslational thinking all the way from molecule to man. This requires the training of a new breed of excellent youngscientists, familiar with the whole scope of drug discovery and development, ADME and safety, systems biology,microbiology and molecular biology.The current Dutch NWO AIMMS STAR programme educates these future experts, combining at least two of these fields andthe translational context. This enables implementation of state of the art techniques into new strategies and approaches tobeat antimicrobial threats, such as the recent Ebola epidemic.With the aid of the proposed MSCA-COFUND, the AIMMS STAR programme can be extended internationally with four additional PhD positions resulting in an established international AIMMS STAR PLUS programme, with a dedicated, openselection procedure for top-talented MSc- / PhD-students from across Europe.


**Keywords:** antimicrobials, resistance, top-training, drug discovery & safety, human health, international,  excellence, Master's graduate programme
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Tools for the Omi' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

TOMI is aimed at providing the missing methods and tools of basic ESDA (Electronic System Design Automation) frameworks, that makes practical the OMI concept of Supercell based system design. As a generic objective, the project aims to provide methods and tools that can reduce system development cost and time and improve quality.Hardware design has reached levels of complexity that are making necessary a change in the design processes. Nowadays, several designers are involved in the system development, working at abstraction levels similar to those of software designers. However, there is a considerable shift in time in the evolution of the methods, techniques and supporting environments used at both worlds. It is well known the increase in productivity and quality that reusability, cooperative work support and quality control measurement techniques and tools have provided to software development. TOMI is going to be centered on integrating these techniques supported by a tool set into the hardware systems development. In this context, TOMI's developments are going to be centered on the keys for improvement and success in this domain, based on three major, interdependent, pillars:- The ability of the OMI vendors and users community to handle an increasing amount of Supercells competing for the market. This translates into a Management Environment able to deal with multiple, continuously improving, and concurrent versions. It also means the need of environments able to support the different Supercells views needed to make the open" idea really operative. The development of a Configuration management system tailored to hardware design in VHDL will also improve the cooperative work and the systems maintainability. - The ability of the OMI vendors and users community to ana
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The origins of gestural imitation: insights from evolution, development and cultural transmission""' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The ability to copy others lies at the heart of our capacity to learn languages, social rules and acquire material culture. While imitation is a core feature of human life, understanding how it evolved, how it develops and the role of cultural transmission are not fully understood. Moreover, most of our understanding comes from studies of tool use, while neglecting the role of imitation in other contexts, namely communicative interactions, such as gesture. Considering the key role gesture itself plays in human communication and in language evolution, understanding the mechanisms underlying gestural imitation is thus essential for assessing how human culture and communication relate. The aim of this project is to conduct a multi-dimensional investigation of gestural imitation from evolutionary, developmental and cultural perspectives. Combining these complementary angles provides a richer understanding of how communication and culture relate, how they evolved and develop and how transmission processes influence them. To examine the evolution of gestural imitation, the Fellow will examine whether bonobos, an understudied species of great ape, can copy a novel gesture. From evolution to ontogenetic development, the Fellow will next examine the development of gestural imitation by comparing children’s imitation of gestures versus technical actions. Finally, recent research shows that transmission processes shape the structure of language and technologies and so the Fellow will explore how cultural transmission (a form of imitation) shapes gestural structure using diffusion chain experiments. Different types of gestures will be compared to test whether transmission shapes signal structures in language-like ways. The Fellow’s expertise in ape communication complements the Sci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European Contest for Young Scientists 2019' (EUCYS2019).

assistant: **Innovation**

The European Union Contest for Young Scientists (EUCYS) has been organized since 1989 with the aim of promoting science and research among Europe's youth and bringing together the talented youth of Europe to meet others with similar abilities and interests and to communicate with some of the most prominent scientists in the world.Bulgaria will organise EUCYS for the first time in 2019, but the organisers have rich previous experience in hosting similar events, which have been organised with the partneriship and support of the Ministry of Education and Science(MES), and the key expertise of the Institute of Mathematics and Informatics of the Bulgarian Academy of Sciences (IMI BAS), a public research organisation with more than 40 years of experience in bridging education and research. This partnership will continue, with MES as a leading organization and  IMI-BAS, stepping in as a linked party of the ministry responsible for the coordination and implementation of the competition programme and the parallel scientific and cultural activities.The contest will bring together more than 150 young researchers from more than 40 countries. Furthermore, a pilot alumni parallel program will gather former participants in the contest and lay the foundations of a future EUCYS alumni network. For four days the participating projects will be interviewed by jury composed of leading European scientists and will compete for European Union prizes, special prizes and host organization prizes. In their free time the participants will be offered the opportunity to visit Bulgarian research institutions and historical monuments with Europe-wide significance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Computational applications to molecular recognition and design of novel biomolecules' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The aim of this research work is to gain new fundamental knowledge about the molecular recognition process by combining advanced computational tools with structural data. The rules which govern protein-heme recognition and the function of this biomolecular complex have already begun to be investigated and explored. New structural data, optimal molecular recognition features and the combination of global and local structural information of the protein-ligand complex will provide a knowledge-based tool to help to design a drug or / and novel protein molecule. Finally the challenging goal of the current project is to extend the study of protein-ligand interactions and to use all this information as a model to design a simple heme - binding protein.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'International meeting on canyon systems 2001' to be submitted under Fifth Framework.

assistant: **Abstract**

This proposal is directed at the preparation and organization of the CANYONS 2001 meeting. The CANYONS 2001 meeting will bring together a number of selected, internationally recognized EU and US scientists in the fields of canyon research. The CANYONS 2001 meeting will result in a State of the Art assessment of the role, functioning and importance of canyon systems for ecosystem functioning and for the sustainable use and exploitation of the marine ecosystem. This assessment will be prepared by the partners in this proposal in the form of a Report, which will be distributed to participants and relevant organizations in the EU and abroad. This Report will also be disseminated electronically.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Detailed morphology, acoustic character and stability of the upper continental slope of Baie des Anges, French Riviera' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The upper continental slope of the Baie des Anges (French Riviera) is characterised by a narrow and steep slope with important areas of underconsolidated, thus potentially unstable, surficial sediments. For a detailed geomorphologic analysis of the upper slope as the basis for the identification of areas of erosion and deposition, their morphology and acoustic character, this study proposes a synoptic approach, integrating multibeam bathymetry, high- (SAR) and mid-resolution (SeaMARC I) side-scan sonar, 3.5 kHz, airgun and Boomer Huntec seismic profiles, sediment cores and bottom photographs. After establishing the nature and relative importance of processes responsible for the present day morphology, the determination of the size, timing and frequency of recurrence of slope failures and associated mass-movements in the initiation area will allow the tentative calculation of sediment fluxes within the slope and between slope and basin. The integration of a geomorphologic with a previous geotechnical zonation will lead to the re-evaluation and improvement of the previous slope stability analysis. The frequency of recurrence of past failure events will provide a test for the assessment of the geological hazard in a densely populated and industrialised region, where future failure events may cause great damage.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Models of the maternal and fetal cardiovascular systems coupling via uterus and placenta' (MEASURE).

assistant: **Innovation**

Complications occur in 5-10% of pregnancies, resulting every year in 2.6 million stillbirths and 303,000 maternal deaths. There is established evidence that complications and stillbirth are associated with abnormal development/adaptation of the cardiovascular system (CVS) during pregnancy. However, the literature lacks a holistic approach and only a few limited aspects have been investigated. Therefore, MEASURE aims at pursuing a holistic investigation of the CVS and the coupling between its subsystems (fetal and maternal CVS), mediated by the uterus and placenta. Synchronized Doppler and electrophysiological acquisitions will be performed to produce a unique dataset for the identification of a mathematical model describing the CVS. This will be achieved through robust and accurate extraction of time series representing the characteristics of the CVS in healthy pregnancies. Through an innovative aggregating strategy proposed to improve clinical reliability, the obtained model will be translated into a coupling map, i.e., a graphical representation of the relationships between the CVS subsystems and their variables. Being more intuitive and easier to interpret, this representation is particularly suitable for its clinical use and uptake. Finally, the comparison between the coupling maps of healthy and complicated pregnancies will allow identifying anomalies in the interactions between the CVS subsystems and designing/training a machine learning classifier to automatically discern between them. The outcomes of MEASURE will improve our understanding of the physiological mechanisms underlying pregnancy and original causes of complications, paving the way for the development of novel, powerful, diagnostic tools for timely diagnosis and, possibly, prediction of pregnancy comp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Socio-physical Interaction Skills for Cooperative Human-Robot Systems in Agile Production'.

assistant: **Innovation**

Collaborative robotics has established itself as a major force in pushing forward highly adaptive and flexible production paradigms in European large and small-medium enterprises. It is contributing to the sustainability and enhancement of Europe’s efficient and competitive manufacturing, to reshoring production, and to economic growth. However, still today the potential of collaborative technologies is largely underexploited. Indeed, collaborative robots are most often designed to coexist and to safely share a working space with humans. They are rarely thought to enter in direct socio-physical contact with humans to perceive, understand, and react to their distress or needs, and to enable them to work more productively and efficiently through better ergonomics. SOPHIA responds to this need by developing a new generation of socially cooperative human-robot systems in agile production. Its modular core technologies will enable dynamic state monitoring of the human-robot pair and anticipatory robot behaviours to: (1) improve human ergonomics, trust in automation, and productivity in manufacturing environments, and (2) achieve a reconfigurable, flexible, and resource-efficient production. By advancing the decisional autonomy and interaction ability of its innovative collaborative systems, SOPHIA will contribute to the reduction of work-related musculoskeletal disorders, the single largest category of work-related injuries and responsible for 30% of all workers’ compensation costs. SOPHIA’s societal relevance and the research groups’ experience in acceptability and standardization aspects of its core technologies will ensure their comfort-of-use by industrial workers, and the underlying design compliance to standards, thus strengthening the competitiveness in European manuf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Obesity and disease in ageing (OB-AGE)' under Fifth Framework.

assistant: **Concept**

Two white adipose tissue hormones, adiponectin and lepton, limit entopic lipid accumulation. In obesity adiponectin levels drop and lepton levels increase and lepton insensitivity" occurs, resulting in entopic lipid accumulation and type 2 diabetes and cardiovascular disease and low levels of growth hormone perpetuating obesity. Thus, we will evaluate lepton receptor (Ob-Rib) function together with adiponectin concentrations as prognostic/diagnostic tools for the development of age related obesity and diseases. Conjugated linoleum acids (Class) and polyunsaturated fatty acids (n-3 Pupas) can decrease entopic lipid and we will evaluate their use in combination, as a natural and novel therapeutic agent to counter obesity related disease. Abdominal WAT is causative in obesity related disease. We will compare differences between abdominal WAT and other depots to identify further mechanisms in obesity related disease."