RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Complex Automata Simulation Technique' to be submitted under Sixth Framework.

assistant: **Abstract**

COAST will develop an innovative concept, Complex Automata, offering a new framework for multi-scale, multi-science simulations. A Complex Automaton is a scalable hierarchical aggregation of Cellular Automata and agent-based models with appropriate couplings. The COAST framework will be validated on a challenging biomedical application aimed at treatment of coronary artery disease.Complex Automata, a generalization of Cellular Automata, facilitate coupling of all spatial and temporal scales present in a complex system. The issue of subsystem coupling will be addressed using a scale splitting methodology to discover effective simulation strategies. The nature of the coupling and mutual distance on a scale separation map will be key factors to foster simulations crossing length and time scales. The framework also includes agent-based models, as a mechanism to merge Euclidean with Lagrangian worldviews. A theoretical formulation of the proposed framework will be developed so as to offer an effective modelling language to describe complex systems.The biomedical application is targeted at drug-eluting stents used to prevent re-stenosis of coronary arteries. It amounts to coupling biological processes acting on the micron scale up to haemodynamic processes acting on the centimetre scale (hydrodynamics, advection-reaction-diffusion, fluid-structure interaction, particle transport in boundary layers, tissue growth, and single cell response). These processes also involve widely separated time scales, from seconds to months. The resulting simulation will be validated with available in-vivo data and be used to study several designs of drug-eluting stents.COAST will result in a powerful complex systems modelling methodology, opening the way for a formal description of multi-scale m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Sustained Concerns: Administration of Mineral Resources in Central Europe, 1550-1850' to be submitted under Horizon Europe.

assistant: **Abstract**

Early modern mining often played out as a drama in three acts: I. Ores are Discovered, II. Communities Flourish, III. The Mines Collapse. Across Central Europe, however, this drama took an unusual turn: emerging territorial states stepped in to reorganise the sector and suspended the collapse of mining for years, decades, and centuries.Understanding why and how state-employed administrators prolonged the lifespan of mines has great potential to advance debates in economic history, history of science and technology, and environmental history. The principal aim of this project is to open up the history of resource management as a field of study whose questions and results are equally well integrated in these three fields. It will use Central European mining as a high-stakes case to prove the viability of such a history. By doing so, it will provide(1) a new account of capitalist development by showing how an industry in seemingly underdeveloped Central Europe shaped two important building blocks of modern economies: the rationalisation of labour, and the accumulation of capital.(2) a new understanding of technoscientific innovation in proto-industrial settings by showing how administrative procedures (accounting, reporting) shaped scientists/technicians understanding of natural processes.(3) a new genealogy for modern sustainability by focusing attention on the contradictions that shaped the extraction of non-renewable resources.To achieve these aims, four researchers (1 PI, 1 Postdoc, 2 PhD) will analyse thousands of administrative reports from across Central Europe, using a new method, history of bureaucratic knowledge, based on recent advances in the history of science. They will work on four processes through which administrators made mining a long-term enterprise: (a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Cognition And Nutrition' (CAN) targeting Horizon 2020.

assistant: **Abstract**

Since 2014, cross-section and interventional work at the Nutrition Research Centre Ireland, Waterford Institute of Technology has demonstrated the importance of good nutrition, and the benefits of targeted nutritional supplementation, in optimising the neurocognitive environment. Research at the centre has intensified over the last few years to support a biologically plausible rationale whereby nutritional intervention can positively impact on cognitive outcomes in cognitively healthy and mildly impaired individuals. Importantly, what remains to be fully understood is the specific brain regions and neural networks that are potentially mediated by nutrition. Inspiring new programs of medical research can translate findings from nutritional science into innovative clinical assessment tools, technologies, and therapies to advance the practice of modern medicine. At the frontiers of this path-breaking effort is research within the emerging interdisciplinary field of nutritional cognitive neuroscience (NCN), which was established at the Decision Neuroscience Laboratory, University of Illinois. Using state of the art methodologies and technologies from the fields of nutritional epidemiology and cognitive neuroscience, NCN aims to advance our understanding of the beneficial effects of nutrition on the ageing brain. The Cognition And Nutrition (CAN) project will generate new knowledge within the NCN field to better understand the ways in which aspects of brain structure and function can be supported by particular nutrients and dietary patterns. In addition, CAN will stimulate interdisciplinary collaboration and bi-directional transfer of knowledge between both centres. Ultimately, this work will have profound implications for understanding healthy brain aging and for treating a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Disruptive Innovation to Treat Alzheimer’s and Parkinson’s diseases: new target, new patented drug, new therapeutic strategy.' under Horizon 2020.

assistant: **Concept**

Neurodegenerative disorders represent the most important medical, social and financial challenges for the 21st century. In 2018, the world counts 50 million people with Alzheimer’s disease and 7 million with Parkinson’s disease, and the number of cases will double before 2050. The current medical paradigms, which incriminate amyloid plaques as the main culprits of these pathologies, do not provide a cure or even stop the progression of the diseases. All clinical trials based on anti-plaques immunotherapies have been unsuccessful. The reason for this global failure is quite simple: these strategies are based on the wrong targets. Indeed, there is no correlation at all between the neurological symptoms and the presence of amyloid plaques in the brain. Thus, the paradigm linking amyloid plaques to neurodegenerative diseases has been totally wrong. AmyPore action plan has been totally different from these unsuccessful approaches. Firstly, we rely on top-level academic researchers who identified the real molecular mechanisms that are the direct cause of the diseases: the amyloid protein oligomers which are responsible for an overdose of calcium in brain cells (amyloid pores). Secondly, AmyPore has taken advantages of the recent artificial intelligence revolutions in neurosciences for identifying a new biological code and optimizing the design of AmyPore lead product candidate. AmyPore solution, called “AmyP53” is the disruptive innovation that has demonstrated to be in the position to overcome these terrible diseases. As a matter of fact, relying upon :-an exclusive license, linked to an international patent owned by the inventors,-recent scientific publications,-and additional recent conclusive tests,AmyP53 is :-easy to test,-easy to produce worldwide,-easy to administer.Am
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mobility of signals in plant resistance to disease' (2002-2006).

assistant: **Innovation**

Plants have evolved sophisticated mechanisms of immunity against pathogens that limit the spread of disease and induce protection of systemic healthy tissues from secondary infections.The latter form of defence is called systemic acquired resistance (SAR) and is induced distally in plants by pathogens that trigger a local resistance response including programmed cell death. In essence, the plant sacrifices locally infected tissues to protect remaining cells from damage.Processes controlling local defence are increasingly well defined but the nature of long distance signals that induce SAR is a major outstanding question in plant biology today. SAR is a long-lasting potentiated state of resistance that acts against a broad range of pathogens. In this primed state, defences are not constitutively activated but are more rapidly and effectively triggered by subsequent pathogen attack.In agriculture, artificial induction of known defences can protect crops against disease but the energy costs are high to the pl ant and the crop yield penalty therefore severe. An important scientific breakthrough would be to identify plant signals, such as those controlling SAR, that potentiate defences against a broad range of pathogens without significant loss of yield.This project will apply state-of-the-art proteomics and lipid profiling technologies at high resolution to two model plants, Arabidopsis and Nicotiana benthamiana, in a comprehensive study to identify protein and lipid-derived SAR signals in crucifer and solanaceous plant species.A multi-disciplinary approach combining genetics, pathology, and molecular biology will be used to validate newly identified SAR signals and track movement of signals in the plant upon SAR induction.The project will provide a solid basis, including m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A plug and play PHOTOnics based bioSENSing platform for salmon pathogen detection', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The UN's 2030 Agenda, adopted by world leaders in 2015, represents the new global sustainable development framework and sets 17 Sustainable Development Goals (SDGs). Foremost is the Zero Hunger SDG, which seeks to end hunger and malnutrition, and ensure access to safe, nutritious, and sufficient food. One of the most productive and efficient sources remains aquaculture, which is the process of rearing, breeding, and harvesting of aquatic species, in controlled aquatic environments, like the oceans, lakes, rivers, ponds, streams and purpose built Recirculating Aquaculture systems (RAS). According to the UN’s Food and Agriculture Organization (FAO), aquaculture is growing faster than any other major food production sector, with 50% of all sea food consumed is obtained by aquaculture. We are currently standing at a critical juncture to maintain healthy aquaculture conditions. To do so we need to continuously monitor the living environments of the fish and apply cutting edge bio-sensing to safeguard these fish farms and therefore our food security. The current consortium brings together the latest in biosensor technology, scaling up procedures, and aquaculture expertise, to safeguard our food security in the present and future years. By becoming an aquaculture pathogen testing hub and bringing to market a working diagnostic platform monitoring salmon pathogens, the consortium [Surfix (NL), Phix (NL), TunaTech (DE), CSEM (CH), and LRE Medical (DE)] aims to provide a long-term solution to ensure our collective food security. This project will build upon the BIOCDx project (ID: 732309) which successfully delivered a working prototype, however, due to lack of scalability, the overall costs of the biosensor remained very high (~€500/chip). Thus, the principal aim of PHOTO–SENS i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DNA sensor in polymer photonic crystal band-edge lasers with integrated nanochannels' (DNA-DAR).

assistant: **Concept**

The proposed project will develop a polymer-based optofluidic lab-on-a-chip device to study the physical dynamics of label-free DNA molecules. DNA contains the complete genetic code of an organism, yet it is the interaction of DNA with other molecular species that determine how that code is interpreted. Moreover, it has been suggested that there are other factors beyond the genomic sequence that are involved in an organism’s complexity. Subsequently, this project will study the physical dynamics of DNA by spatially profiling its restriction and extension attributes as it propagates along integrated nanochannels. The operating principle of the device will be based on the refractive index (RI) perturbation caused by a DNA molecule as it passes through an optical detector region. The optical detection scheme will use band-edge lasers in photonic crystals to monitor subtle shifts in wavelength caused by the change in RI. This will result in a label-free approach to characterise DNA, circumventing the negative effects of dye staining – a common DNA investigation technique – that prevents true measurements of the molecule’s behaviour. The device material will be polymer-based, offering an affordable development trajectory via nanoimprint technology. In addition, polymer is a suitable material for introducing active dopants, such as fluorescent dyes, to generate the photonic crystal band-edge laser components. Finally, the integration of nanochannels to the devices offers several novel advantages: the nanochannel provides a straightforward approach to deliver DNA to the detector regions; the nanochannel confines DNA, causing an extension of its molecular conformation and allowing access to structural detail otherwise difficult to obtain; and the nanochannel dimensions provide
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Fusarium oxysporum mediated underpinning of cell type-specific modulation in multiple host interaction' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Fungi have a devastating impact on human nutrition and health. Each year, fungal pathogens provoke enormous agricultural losses in crop plants and contaminating food with harmful mycotoxins. The soil-borne fungal pathogen Fusarium oxysporum infects plant root and vascular tissue, causing wilt disease in over a hundred different crops, including both dicots and monocots. A particular aggressive strain of this pathogen, tropical race 4, is threatening banana plantations worldwide. Currently, there is little information on the crucial biotrophic infection stage of vascular pathogens, from penetration of root to colonization of xylem vessels. Fusarium provides an excellent model to investigate the cell-specific sensing and adaptation and suppression of plant immunity related to early infection stages. The host group has recently reported the chemotrophic sensing mechanism used by this pathogen, and identified host plant signals perceived by Fusarium in the soil. Moreover, their work revealed a combined action of enzymes involved in fungal cell wall remodelling and plant cell wall degradation which contributes in virulence of this pathogen. In this project, we aim to identify the cell-specific virulence genes that F. oxysporum uses to colonize a dicot host (Arabidopsis) versus monocot (Banana) that has a fundamentally distinct vascular tissue architecture. We will use dual RNA-Seq coupled with Laser capture microdissection (LCM) to identify core compatibility components in both the pathogen and the plant, that are essential for establishing wilt disease. This will lead to identification and characterization of potential targets in this interaction that could be used to develop novel resistance strategies in ongoing banana breeding efforts. This project will thus advance fund
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Forward Slice Core' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

There are two major flavors of processor core microarchitectures, namely the in-order core and the out-of-order core. Out-of-order processors deliver high performance while incurring high design complexity, large chip area and high power consumption. In-order processors on the other hand feature low complexity, small chip area and low power consumption, but deliver limited performance. There is a clear need for a novel core microarchitecture that delivers high performance at low hardware complexity, low cost and low power consumption. This is of particular interest for mobile and edge devices (e.g., tablets, smartphones, smartwatches, etc.) where increasingly high performance is needed at low cost and low power consumption. The mobile and edge device market is a huge market which continues to grow. High-performance out-of-order processors are too costly and too power-hungry, while in-order processors deliver insufficient performance for the increasingly high-performance demands of emerging mobile and edge workloads and use cases.We propose a novel core microarchitecture, called the Forward Slice Core (FSC) microarchitecture, which provides high performance at low cost and low power consumption. FSC achieves a dramatic improvement in efficiency by replacing the expensive and high-complexity out-of-order hardware with much simpler in-order hardware queues into which instructions are intelligently steered for high performance using the notion of a load's forward slice. FSC has the potential to improve performance per Watt per euro by at least an order of magnitude. The overall objective of this PoC project is to build a strong benchmarking and IPR portfolio to convince potential processor manufacturers to license the Forward Slice Core microarchitecture. The project will s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Design, manufacture and deliver a high performance, low cost, low weight Nacelle Structure for Next Generation Tilt-Rotor (NGCTR)' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The aim of the Clean Sky 2 topic JTI-CS2-2018-CFP09-FRC-01-26 “Design, manufacture and deliver a high performance, low cost, low weight Nacelle Structure for Next Generation TiltRotor (NGCTR) - Technology Demonstrator (TD)” is to develop innovative: lightweight materials, architecture, technologies, fire resistant materials, control of structural borne vibration to be applied on the Nacelle of the NGCTR under supervision of Leonardo Helicopters Division. TRAIL Consortium shall meet the target by introducing advanced composite materials and designing highly integrated monocoque structure of the Nacelle with use of OoA (Out of Autoclave) and VARTM (Vacuum Assisted Resin Transfer Method) manufacturing techniques. In the frame of the project lightweight hybrid firewalls (composite with elastomeric coating) shall be investigated to produce lighter structure. The project will also deal with novel means to damp structure borne vibration and noise through application of viscoelastic materials into the NGCTR TD Engine Nacelle design.The realization of the project shall lead to significant weight of the structure and number of parts reduction. It shall also show that decreasing manufacturing costs and time is possible and lead to introduction of technologies which shall reduce environmental impact of air transport and aviation industry.


**Keywords:** Next Generation Civil Tilt Rotor, Engine Nacelle, Design, Manufacturing