RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nanoelectronics based on two-dimensional dichalcogenides' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Semiconductor industry rapidly approaches the performance limits of silicon-based CMOS technology. This proposal aims to pave the wayto electronic circuits based on two-dimensional transition metal dichalcogenides (TMDs), newly emerging semiconducting analogues ofgraphene. TMDs can be rapidly exfoliated in the liquid phase into single layers starting from powders and provide solutions of 2D materialsthat can be coated over large areas. The recently achieved transistors based on single-layer MoS2 indicate a mobility comparable or evenhigher than silicon thin films or graphene nanoribbons, but with much lower leakage currents. In a joint effort of wet and gas phasechemistry and deposition techniques, nanoanalytics, electronic and optical spectroscopy, electronic device fabrication and characterisation,and theoretical modeling we aim to control the production and deposition of TMD nanolayers and nanoribbons, understand and control theinterplay between morphology, defects and electrical properties, understand electrical transport through semiconducting nanolayers, andfabricate nanodevices. By combining the ease of processing commonly associated with organic electronics with superior electricalproperties, we will demonstrate a new type of low-power, low-cost field effect transistor based on a single TMD layer and/or nanoribbon.The proposed outcomes of immediate interest for the three full partners from industry are (i) process flows and practices that enablefabrication of nanoscale transistor arrays for application in flexible electronics via spraying and/or ink-jet printing, (ii) software packages formodeling the electronic behavior of TMD nanolayers, and (iii) a prototype reactor for their large-scale growth and deposition. The trainingand dissemination activities will be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The first commercial CubeSat Constellation for early detection and real time monitoring of wildfires across the entire globe' (OroraTech) under Horizon 2020.

assistant: **Objectives**

OroraTech aims to launch a constellation of 100 CubeSats (the biggest one in Europe and the third biggest in the world) to provide high resolution thermal images of the entire globe enabling the automatic detection and real time monitoring of wildfires across the globe. Fuelled by rising temperatures, wildfires have become more common, deadly, expensive and difficult to contain, resulting in over 200 deaths and damage >€23bn in the EU and US alone, in 2018. Their causes are unpredictable and so the only solution is early detection and suppression. With 4% of the earth’s surface affected, there are no technologies to viably provide continuous high resolution monitoring, with current satellite technology either having a too low resolution or inadequate overpass frequency.OroraTech provides a breakthrough by integrating the latest advances in miniature electronics, computing and space technology to deliver the first commercially viable CubeSat delivering high resolution thermal imaging. We will cover the whole earth at 0.1% of current satellite technology costs providing 24hr surveillance at a high resolution delivering data in a matter of minutes. This will reduce fire suppression costs by 25% and detection infrastructure capital costs by up to 90% resulting in global savings in the order of billions of euros. With wildfires contributing 20% of global CO2 emissions annually, our solution potentially reduces global CO2 emissions by >2%.We are attacking a high growth market worth over €7bn/yr by 2027 with over 16 million potential customers in EU alone. We have already received the support of the German Aerospace Centre, European Space Agency, and Global Fire Monitoring Centre, and attracted the attention of the biggest forest service (US) in the world.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Energy Saving Through Low Cost Pump Efficiency Meters', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

The only time that the perfomance of most pumps is known accurately is when the pump is tested on the manlufacturers test rig. Once the pump is delivered, installed and running the operator has no transferable standard by which to judge the efficiency of the pump. In a survey of over 2500 pump tests carried out for the UK water authorities water pumps were found to be operating with efficiency shortfalls of an average 12,5%, 20% in the case of process pumps. This represents a considerable, and unnecessary energy consumption. A 1% increase in pump efficiency throughout European industry would reduce the European energy costs by more than 2 Billion ECU per annum. A unique thermodynamlic technic. patented by AEMS Ltd is used to measure the operational efficiency of large pumps ( >150KW ) in the operational environment without disruption to the pump schedule and functionality. Extremely precise measurements of temperature and pressure have to be taken and the system cost is such that the technique, although extremely accurate and simple to implement, is not currently suitable for routine monitoring of smaller (25KW - 150KW), lower cost pumps which make up the majority of industrial applications. The objectives of the pro ject can be summarised as follows; a) To research and develop the technologies necessary tve a practical low cost pump efficiency meter capable of giving a useful indication of pump performance in an operational environment. This study will incle the research and development of the necessary sensors and transducers and will incorporate advances in sensor, microprocessor and communication technologies. b) To confirm the accuracy and performance of various types of meter ded through extensive testing and demonstration in practical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Nutraceuticals for a healthier life: n-3 polyunsaturated fatty acids and 5-methyl-tetrahydro-folate'.

assistant: **Objectives**

The project will for the first time undertake a comprehensive, in-depth evaluation of the beneficial roles and interactions of long-chained n-3 polyunsaturated fatty acids (n-3 LC PUFA) and 5-methyl-tetra-hydro-folate (5-MTHF) in cardiovascular health and infant development. It will investigate effects on CVD-related biomarkers and on the development of infants, when mothers had been supplemented during pregnancy. The information obtained will allow the development of various functional foods enriched with stable forms of these nutraceuticals, thereby providing an optimum taste profile and ensuring consumer acceptability. These functional foods will help to reduce the deficit between current intakes of these nutrients and their actual requirement for optimal health in a large proportion of the European population. The products will also be of high commercial value to the European food industry.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Vaccine Targeting Eradication of Malaria' (UltiMalVax) targeting Horizon Europe.

assistant: **Abstract**

Malaria killed about 640 thousand people in 2020, largely young children in Africa. Rapid recent progress has led to two anti-sporozoite vaccine developers planning WHO prequalification applications in 2022. These include the new high efficacy R21/Matrix-M vaccine, to be supplied at the required large scale, and led by partners in this consortium. In parallel, recent progress with transmission-blocking malaria vaccines has led to substantial efficacy in a first direct skin feeding field trial. This opens up the prospect of a two-stage vaccine targeting both sporozoites and sexual-stage parasites that should have a major impact on malaria transmission, thereby enabling regional elimination and ultimate eradication. We propose here to develop such a vaccine assessing both established virus-like particle (VLP) vaccines in potent saponin adjuvants and also exciting new thermostable mRNA vaccines expressing the parasite antigens now showing high efficacy. Importantly, we will adopt new VLP design technologies, e.g. SpyCatcher bonding, that allow bivalent antigen display, to enable a single vaccine to protect against both the Plasmodium falciparum parasite, which causes most deaths, and the more widespread Plasmodium vivax parasite. A lead vaccine candidate will be down-selected based on well-studied pre-clinical efficacy models and induction of functional transmission-blocking antibodies, prior to GMP manufacture and a clinical trial in year 4.The consortium brings together academics, non-profits and a wide range of companies with both leading technologies and access to small and very large scale GMP manufacturing capacity. This programme builds on the recent success of several partners in the R21/Matrix-M programme and aims to accelerate the malaria eradication agenda by pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'In vivo analysis of the p53 and p73 tumor suppressors using a unique mouse model' (Oncoswitch).

assistant: **Innovation**

Cancer is the second cause of death in Europe, after cardiovascular diseases. These lethal diseases are in desperate need of new therapeutic approaches: despite dramatic advances in the use of conventional chemo and radiotherapy and the growth of more “targeted” drugs, many cancers are still incurable.Cancers are difficult to treat not because they are so mechanistically diverse (indeed, we argue that cancers are not very diverse mechanistically) but because they evolve in response to any pharmacological elective pressure we impose upon them.To address this problem, we employ a novel class of genetically engineered mouse (GEM) in which individual tumour suppressor genes may be systemically toggled off and on, reversibly and at will, in vivo. In this way we can identify the most effective therapeutic targets. We hypothesize that targeting the functionally non-degenerate signaling nodes that link robust networks offers two unique advantages as a therapeutic strategy: a durable therapeutic response, and the possibility for treating many distinct cancer types. In this project, we will focus our attention to the non-redundant tumor suppressor p53, and investigate its relevance as a discrete or combined therapeutic target for the treatment of cancer and protection of individuals from radiological or chemotherapeutic injury. Furthermore we will also examine the potential tumour suppressor role of p73, with the same technical approach.Our overarching aim is to deliver to the pharmaceutical industry pre-clinical models of what drugs would do, both therapeutically and in terms of side effects, were we are able to target any intracellular effector of choice.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Experimental characterization of turbulent pressure fluctuations on realistic Contra-Rotating Open Rotor (CROR) 2D airfoil in representative high subsonic Mach number'.

assistant: **Concept**

Prediction of Open Rotor broadband noise requires  boundary layer statistics that, for the high subsonic relative Mach number encountered by the blades, are not available today in literature. The CRORTET project, fills this lack by preparing and executing a high fidelity wind tunnel test, analyse the results and deliver a well documented data base with test data. One of the major sources of broadband noise is due to the deformation and interaction of the turbulent vortices in the rotor blade boundary layer when they pass over the blade trailing edge. Existing semi-analytical models for the prediction of broadband traling edge noise emission require turbulence statistics of the surface pressures close to the trailing edge, namely: the fluctuation spectrum, convection velocity and spanwise correlation length of the surface pressures. Existing experimental data were made on flat plates, NACA0012 or similar airfoils at low Mach number, No experimental data nor high fidelity simulations are available for the high subsonic Mach conditions encountered by the rotor blades operating in approach (0.5), take-off (0.7) and cruise (0.9) conditions. Applying semi-analytical methods to these conditions, using inappropriate surface pressure statistics shows a shortfall in comparison to open rotor experimental data. It is thought that this is mainly due to the use of low Mach number data on profiles too much different from CROR blade profiles.Therefore, in the CRORTET project two airfoils will be specifically designed, manufactured and tested in the DNW-TWG wind tunnel at full scale Reynolds number (representative for a front row CROR blade at 75% blade span) and in the appropriate Ma range. One of those airfoils is a reference airfoil (e.g. a NACA0012 or similar), the other airfoil wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of the chromatin protein HMGN3 in cytokine-induced gene expression' (KLW-HMGN-CHEMOKINES), addressing dissemination and exploitation.

assistant: **Impact**

HMGN proteins promote chromatin unfolding, enhance access to nucleosomes, and modulate transcription from chromatin templates. A major question is whether HMGN proteins act indiscriminately as general facilitators of transcription, or whether they act specifically to regulate the expression of particular target genes. Furthermore, the lack of known gene targets has hampered research into how HMGN proteins modulate transcription in vivo.This proposal focuses on a new member of the HMGN family, HMGN3a, and its splice variant, HMGN3b. In my postdoctoral studies at the NIH in the U.S.A., I identified several gene targets for HMGN3. I have recently taken up a lectureship at the University of Glasgow in the UK, with the aim of establishing my own research laboratory. My start-up funding is very limited, and I am applying for an IRG to help fund my research and thus promote my integration into the European Research community. I propose to build upon my previous research and use one of the HMGN3 target genes, the chemokine IP-10, as a model system to investigate the mechanism of action of HMGN3. I have created cell lines in which the expression of HMGN3a or b can be induced by doxycycline. This is a highly controlled system for studying the role of HMGN3a/b in vivo.I will use these cell lines to further investigate the role HMGN3a/b in cytokine-induced gene expression. I will then use chromatin immunoprecipitation (ChIP) assays to investigate where HMGN3 binds to the IP-10 gene in vivo, and whether this correlates with the profile of histone modifications across the locus. I will assay DNA accessibility over the gene to determine whether HMGN3 plays a role in unfolding chromatin. I will also investigate whether HMGN3 alters the rate or extent of transcription factor binding usi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Advanced Manufacturing Ecosystem improvement', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Industry foresight for next 10 years are highlighting how the global economy will be fully globalized and competition for markets will become fiercer. New industrial players from emerging and newly emerged industrial economies will fight for market share with multi-nationals and companies from traditionally industrialized countries, including the EU. This will drive companies seeking for innovation to develop a competitive edge for new products and services, and to adopt operations that are more efficient. Europe is a global leader in supplying advanced manufacturing technologies, however notwithstanding the relevant investment in R&D to develop such technologies, the effective uptake is still weak and European companies are lagging behind in comparison to global competitors regarding demand and use of them.  Despite the benefits AMTs offer, the majority of manufacturing SMEs in the EU are not yet using these technologies. One of the key obstacles to AMT adoption is represented by the general weakness of the support system supplying with adequate capacities in all areas of advanced manufacturing sector. The overall project objective of the project is to improve the Advanced Manufacturing Ecosystem for European SMEs by reinforcing the innovation infrastructures that should provide support to manufacturing SME. The aim is thus to collaboratively address a common innovation support challenge consisting in providing adequate support to SMEs in the adoption of AMT. The Peer Learning activity is expected to collect and identify a wide range of services that Innovation intermediary agencies may provide to SMEs to stimulate their transformation through the AMT uptake. The expected Design Options Paper will serve as a “guide” or a “handbook” to other agencies and business suppor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Strategy for the introduction of a Biomass power plant in Spain' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Objectives The main objective of the project is to develop a strategy for the implementation of a biomass power plant in Southwestern Spain, in a region included in objective no.1 of the Regional Development Funds. The determination of this strategy will take into account the biomass potential of the area, the state of the art for biomass electricity conversion, and the technical, environmental and socioeconomic aspects of the power plant implementation. Special consideration will be given to the impact on rural employment and income. The local knowledge of Spanish and Portuguese partners (CIEMAT, CEEETA, TGI, Sevillana) will be combined with the experience in biomass energy of King's College London and Swedish companies. Technical Approach An in-depth study will be carried out by CIEMAT in order to ascertain the regional possibilities for biomass production. Among other aspects, soil, climatology, land use, and socioeconomic conditions will be studied. The most appropriate species, both for herbaceous and forest crops, will be selected by King's College London and CIEMAT and the available forest residues estimated. The technology to be used will be defined by TGI, based on Swedish experience provided by the Centre for Environmental Studies. Once selected, the biomass energy systems, their main implications regarding energy and CO2 balances, the feasibility of connection to the grid and the socio-economic and environmental externalities will be examined by King's College London, CIEMAT, CEETA and Sevillana. The socio-economic and environmental externalities assessment will be based on the ExternE methodology of the European Commission. As a result, the most appropriate strategy for the introduction of the biomass power plant will be agreed by all partners and presented