RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'New drug for the treatment of rheumatoid arthritis' (RheumArth).

assistant: **Concept**

Rheumatoid arthritis (RA) is a chronic autoimmune disorder causing inflammation and permanent damage in joints and surrounding tissues - leading to severe disability, decreased quality of life, and reduced life expectancy. The disease affects more than 6 million people with annual costs amounting to €45billion in the Europe (EU) alone. There is a wide range of drug therapies for RA, mobilizing a variety of anti-inflammatory and immune modulating effects. However, a significant proportion (30%) of the patients do not respond to current treatments, efficacy is often reduced over time and the incidence of side effects is high and can be severe and life threatening.AP1189 is new chemically-synthesized small molecule drug for the treatment of Rheumatoid arthritis (RA). Through specific activation of the patients’ self-anti-inflammatory mechanisms, our first drug candidate renders unprecedent combination of safety, effectiveness and patient compliance, without the side effects associated with current therapies. The clinical validation of our drug for RA - 1st indication (foreseen for the Innovation Project) - will not only open a large market within this therapeutic area, as it will allow Synact to set a market foothold in the chronic inflammatory disease market, supporting the company´s medium term strategic positioning as an unique provider of a new generation of anti-inflammatory drugs. AP1189 clinical validation is on-going with current Phase I clinical trials showing promising preliminary results – safety and tolerance was proved in healthy human volunteers. Next step in the development will be a Phase IIa Proof-Of-Concept (POC) trail to validate our drug´s efficacy profile in RA patients. In this context, the present Phase 1 will be of utmost importance to validate AP11
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Quantifying nitrogen fixation by moss-cyanobacteria associations from community to global scale by developing a novel process-based modelling approach' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Nitrogen (N) fixation by moss-cyanobacteria associations is crucial for N input and productivity in pristine ecosystems. Despite its importance, substantial knowledge gaps exist. Current regional and global estimates of moss-associated N2 fixation are uncertain due to limited sampling and species coverage, leaving the global pattern of moss-associated N2 fixation unresolved. Additionally, the mechanisms driving large variation in N2 fixation across different moss species remain unraveled. This project aims to address the critical knowledge gaps by (1) collecting comprehensive data on N2 fixation from moss-cyanobacteria associations across climate zones under controlled abiotic factors; (2) quantifying the relationship between N2 fixation and abiotic factors in different climate zones; (3) developing a process-based model (LiBry-CyBac) that includes N2 fixation to quantify the impact of the interactions between cyanobacteria and moss on variation in N2 fixation across moss species; (4) applying this model to identify global moss-associated N2 fixation pattern and its implication for ecosystem productivity.Combining my expertise in moss modelling with the host’s expertise in moss-cyanobacteria N2 fixation, this project takes an interdisciplinary approach involving biogeochemistry, ecophysiology, and symbiosis research. The expected high-quality publications, training in experimental design, laboratory measurements and analyses such as gas chromatography, model development, and other professional skills (e.g., grant application writing, student supervision, teaching, and project management) will greatly benefit my career development. The effective dissemination of research results will enhance public awareness of important moss functions (i.e., N2 fixation) and the impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Regional Economic RTD Policy through Foresight and Mentoring'.

assistant: **Innovation**

The REFORM project aims to develop, support and implement a variety of measures and activities, which will enable regions to understand their particular needs to enable increased RTD activity and investment in the future.Through mechanisms such as Foresight and a new Mentoring Programme, the project will develop a number of individual Action Plans for partners, which will provide the infrastructure for new RTD policy and its implementation, and thus increase the economic growth of the EU as a whole.Additional actions, including study visits, workshops and a conference will support the transfer of good practice and knowledge to those regions in the developmental stages of increasing RTD investment, increasing the rate of transfer through hands on support, promotion and participation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Magnesium alloy for bone tissue engineering manufactured by selective laser melting' (MACS) targeting Horizon Europe.

assistant: **Abstract**

One important health issue in Europe, especially with the aging of the population, is bone (tissue) fracture (damage) as a result of high-energy impact or trauma, tumor resection, infection or osteo-degenerative diseases. This problem is currently managed with fixation devices and porous scaffolds made of bio-inert and biocompatible alloys (Ti, Co-Cr, steels). However, the large elastic modulus mismatch between these permanent materials and the bone tissue leads to osteoporosis and secondary fractures. Moreover, secondary surgeries are often necessary to remove these permanent implants. To overcome these limitations, temporary implants from biodegradable and biocompatible metals, such as magnesium (Mg) have been attracted a lot of attention. However, Mg suffers from fast corrosion rates in body fluids, which also impairs cell proliferation and just a few Mg alloys, fabricated by conventional techniques (extrusion and powder metallurgy) have been approved for bone tissue therapies so far. These techniques do not allow to control the porosity (pore shape, size and connectivity), which is necessary to ensure appropriate cell proliferation and tissue growth. Hence, the project MACS aims at developing a new generation of Mg alloys suitable to manufacture by selective laser melting porous scaffolds with optimum porosity, mechanical properties, corrosion resistance and biocompatibility to be used for bone tissue engineering. Particular emphasis will be paid to the engineering of surface coatings to ensure the appropriate rates of corrosion and cell proliferation so the biodegradable scaffold will be gradually replaced by the tissue. Porous scaffolds will be designed and manufactured by selective laser melting with the new alloy and engineered with surface coatings. The mechani
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Colloidal aspects of lipid digestion: the physics behind healthier food', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

An emerging application of colloidal science, due to the growing social and economic consequences of the obesity crisis in the developed world, is the design of healthier foods to control fat uptake in the diet. Consequently molecular mechanisms of digestion and metabolism of lipids are generating renewed scientific interest. Lipase-colipase complexes adsorb onto the surface of lipid droplets to access and hydrolyse fats into a form absorbed by the body (lipolysis). Studies I made on the recent Marie-Curie action (LIPOGEST) suggest that processed food emulsions could be designed to slow rates of lipolysis, inducing satiety, and lowering fat intake in the diet. Use of nanoscience methods to visualise bile salt adsorption under in vitro duodenum conditions suggest that interfacial structures of protein-stabilised emulsions could be designed rationally to control bile salt adsorption, reducing lipase-colipase adsorption and rates of lipolysis. An important aspect of such design is ensuring that modified interfaces survive digestion conditions in the stomach. LIPOGEST enabled me to investigate the effect of stomach conditions on interfacial structures for the first time, identifying new facets of these processes, such as an unexpected synergism between surfactants and proteolytic enzymes in the proteolysis of interfacial layers. Such knowledge offers routes to control proteolysis enabling successful design of emulsions to control fat intake. In the present proposal I intend to consolidate and expand these findings into how the process of digestion affects the structure and stability of model emulsions and interfacial layers. This information will be obtained by using state-of-the-art colloidal characterisation techniques and theoretical models. Through this approach I aim t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European RAMP metering project' under Sixth Framework.

assistant: **Concept**

EURAMP is a comprehensive, up-to-date, representative, collective European action focused on ramp metering control measures in European motorways in the aim of improving safety and increasing efficiency of traffic flow. Daily recurrent and non-recurrent congestions on European motorways lead to a substantial degradation of the expensive motorway infrastructure, reduced traffic safety and excessive environmental pollution. Ramp metering is the most direct and effective control measure towards an optimal, orderly and safe utilisation of the motorway infrastructure.EURAMP comprises some of the most knowledgeable and experienced European actors in the area of ramp metering and motorway traffic control, as well as 5 representative sites (from 5 European countries) ranging from the European ramp metering pioneers (Ile-de-France, The Netherlands) to utter newcomers (Vienna). A description of related user needs and state of developments is a first limited-effort concern of EURAMP. A helpdesk providing advice and support to ramp metering sites will be continuously operated during the project's lifetime. Major innovation areas and end products of EURAMP are advanced network-wide approaches (including an interoperable software prototype) as well as various safety-critical issues and related implications of ramp metering; furthermore, isolated ramp metering as well as integration with adjacent signal control and further control measures are also addressed.New and old developments will be implemented, comprehensively tested and cross-evaluated in EURAMP's sites so as to ensure the achievement of the above stated objectives and foster European competitiveness. A variety of dissemination and exploitation activities, including a 'Handbook of Ramp Metering', will ensure the lasting char
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Modern Optoelectronics On III-Nitrides' to be submitted under Sixth Framework.

assistant: **Abstract**

Using wide-band gap III-Nitrides, blue LEDs, blue lasers, and solar-blind detectors have been successfully demonstrated to date. III-N platform is, however, not limited only to these devices; it potentially offers new devices, applications, and commercial interest far beyond the current point. In this project, we propose to demonstrate new III-N optoelectronic devices that embody nano-scale quantum structures and/or incorporate multiple integrated micro-scale components to operate in the optical spectral ran ge from the visible to the UV at Bilkent NanoTRC. One set of new devices includes III-N, high-speed, quantum electro-absorption modulators for fast data coding and ultra-short pulse generation across the UV-visible. These will enable high-speed optical interconnects and clock injection directly into Si CMOS detectors and chips (at >10 Gbps), e.g., in the blue, by eliminating the diffusion tail observed in the IR. They will also be useful for UV communication (space and underwater), time-resolved spectroscopy in biological and chemical agent detection (ozone depletion, security-threatening anthrax and SARS), and high-speed, high-capacity data storage on Blue DVD. Another set of devices includes III-N integrated optoelectronic circuits. For example, a GaN-based receiver may replace the photo-multiplier-tube (PMT) technology by reaching the PMT sensitivity and providing unprecedented speed. Upon returning from the USA to Turkey, this project will facilitate Dr. Demir to transfer the knowledge and experience he has acquired on quantum structures, integrated optoelectronic circuits, ultra-fast optoelectronics characterization, micro-fabrication and process integration during his last 6 years of research work in collaboration with Intel Co. at Stanford University. W ith i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how '4th european conference on grain legumes: towards the sustainable production of healthy food, feed and novel products - conference participant support.' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The proposed project is to organise an international and multidisciplinary scientific conference on grain legumes in the geographic centre of Europe, Carolina Poland, under the title: Towards the sustainable production of healthy food, feed and novel products ". The combination of plenary and workshop sessions of the Conference will allow attendants to acquire both an updated overall picture in the major areas as well as an advanced view in selected scientific and technical issues relating to grain legumes. The organising Committees will ensure the high standard in the scientific content and the logistics. It is expected that the conference will be a platform for exchange of views between specialists from different countries including NIS, CEEC giving them opportunity to profit from contacts with their Western European colleagues. The applied sum will cover the conference fees for the group of 127 participants from there countries."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Flexible x-ray detectors for large area imagers: towards consumer electronics', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Techniques for non-destructive and non-invasive inspections are more and more required in our society, in different areas such as medical, industrial and security. X-ray radiation and its detection is the current inspection tool, coupled with electronic systems to gather information. However, while the electronic has gone through an impressive development to respond more and more to the need of a capillary presence in our life, without disturbing perception, the X-ray detection has remained behind. Thus, Users are limited to costly, cumbersome, fragile and extremely heavy detection devices, which do not allow nor extension to large areas neither easy integrability/conformability to a large variety of objects. FLE-X will develop the prototype of a low cost, flexible direct x-ray detector for imaging applications, which can be customized. It will be suitable for large areas inspections, and bendable around complex objects. It will be easy to handle. This will be achieved by developing printed thin films (<< 100 um) fabricated from lead-halides perovskites inks. Such device does not exist on the market. Once transformed into a commercial product, it will enable a shift paradigm for the X-ray detection market and will be a gate for new applications. To make this happen, FLE-X will identify the first process flow compatible with industrialization, will deliver a prototype of flexible X-ray imager and will provide a model and business plan which will allow an efficient technology transfer.


**Keywords:** X-ray detector, perovskites, flexible electronics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'COLOR Ordering Templated by Hierarchized Supramolecular Porous FlatLANDS'.

assistant: **Concept**

The idea of this research project is to take advantage of molecular self-assembly to create a new generation of periodically-organized porous organic materials that, acting as specific molecular hosts, can structurally control the positioning of multiple functional guests on surfaces, opening new horizons toward the understanding and development of rationale protocols for the patterning of unprecedented materials. Taking advantage of a supramolecular approach to engineer extended mono- and two-dimensional organic networks, the ultimate aim of COLORLANDS is to create novel hosting frameworks accommodating in a predetermined fashion organic chromophores and/or fluorophores. For instance, these can be oligophenylenes as blue emitters, cumarines/oligophenylethylenes as green emitters, or perylenebisimides conjugates as red emitters. Depending on their spatial organization, such materials will be the springboard for further technological development in the fields of electroluminescent devices or artificial leafs mimicking natural light harvesting antenna systems. The self-assembly of selected rigid molecular modules alternatively functionalized with complementary connectors (PNA strands) will yield, under equilibrium conditions, one exclusive structural pattern. This will feature controllable (in shape, size and chemical nature) periodic receptor sites, each programmed to selectively accommodate a specific molecular chromophore and/or fluorophore. Particular attention will be given to the design and fundamental understanding of specific orthogonal interactions between the self-assembled receptor sites and the functional molecular guests. This will be achieved through the lateral organic functionalization of the PNA strands with novel orthogonal H-bonding-based recognition mo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'In vitro production of high quality mammalian oocytes for biotechnology, assisted reproduction, breeding and toxicology-teratology purposes' in the context of a Fifth Framework call.

assistant: **Objectives**

Our objective is to produce in vitro high quality mammalian oocytes for use in biotechnology, in assisted reproduction techniques, in preservation of genetic diversity, in production of high value added products through transgenesis, in farm animal breeding and in toxicology-teratology. The mammalian oocyte is the Nature's foundation for the success of these new technologies. Ovaries contain a wide pool of oocytes but a considerable wastage occurs: most (>99%) of them are lost during the physiological female cycle and very few complete the capacitation process that leads to further maturation, fertilisation and embryo development. This is the most limiting factor to a wider use of technologies involving oocytes. We will design a new culture system that will allow us to rescue these oocytes and to produce oocytes of uniform quality to be used by the new reproduction-based biotechnologies.ObjectivesThe main objective of the project is to produce in vitro high quality mammalian oocytes for use in biotechnology, in assisted reproduction, in preservation of genetic diversity, in production of high value added products through trans-genesis, in farm animal breeding and in toxicology-teratology. We intend to rescue the oocyte capital by developping a culture system approaching in vivo situation. This new system will allow us to mimic in vitro the block of meiotic resumption provided in vivo by follicular environment and to address to them proper stimulation sequence to induce capacitation. Oocytes will then be allowed to resume meiosis and another stimulation sequence will be addressed. This will produce oocytes of uniform quality to be used by the new reproduction-based biotechnologies. Description of the workFour workpackages have been defined. WP1. Reversible meiosis inhibi