RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The real impact of healthier products on consumption and calorie intake' to be submitted under Seventh Framework.

assistant: **Abstract**

Several Western governments have declared obesity as one of today’s most urgent challenges. One of the remedies suggested to solve the obesity problem has been the development and stimulation of healthier products. Not surprisingly, companies have realized the opportunities, and healthier product versions have become big business. Apart from the low-fat varieties that are now present in almost every product category, also other functional health claims (e.g. extra vitamins) are frequently used. Common wisdom would suggest that the consumption of healthier product versions would indeed increase a consumer’s health. However, recent experimental research has shown that the effect of these healthier products may not be as straightforward as originally thought, to the extent that it may even lead to increased consumption and even calorie intake in certain circumstances.I propose to study health claims in a real-life setting, and examine their effect on actual category consumption quantity and calorie intake both in the short and long term. I use a unique dataset consisting of real purchase data in many product categories for a large household panel, combined with product information such as the type of health claims used and the nutritional information. The large amount of cases will not only allow to generate generalizable knowledge on the effect of health claims on real consumption behavior, it will also allow to study the potential moderating impact of the type of health claim (low-fat versus functional), as well as consumer and category characteristics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Investigating the genetic architecture and pathogenesis of of Herpes Simplex encephalitis susceptibility', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Childhood herpes simplex encephalitis (HSE) is a potentially life-threatening complication of primary infection by herpes simplex virus-1 (HSV-1), a common virus that is innocuous in most children. HSE is the most common sporadic viral encephalitis in Western countries and acyclovir-treated patients often suffer from severe neurological sequels. The pathogenesis of HSE remained unknown until the recent discoveries of Mendelian single-gene mutations specifically impairing immunity to HSV-1 at least in a subset of children suffering from HSE. We have identified mutations in TLR3, UNC93B, TRIF and TRAF3 in patients with isolated HSE, suggesting that impaired type I interferon (IFN) production upon stimulation of TLR3 by dsRNA viral intermediates in the CNS underlies the pathogenesis of HSE in these patients. Despite the identification of these genes, only a minority of the patients tested carried these genetic defects. Hence we hypothesize that childhood HSE is a genetically heterogeneous disease and that other single gene inborn errors of immunity may explain HSE in other patients. As a first objective, we hope to identify novel HSE-causing genes following a candidate gene approach in patients with a cellular phenotype. The TLR3-IFN pathway will be tested and the known genes sequenced. For those without any mutations in known genes, alternative approaches such as cDNA complementation and RNA sequencing will be carried out. In addition, we also aim to understand the cellular basis of the pathogensis of HSE as most our studies have been carried out on patients’ fibroblasts. We hope to characterize the TLR3-dependent type I IFN production in response to dsRNA and HSV-1 in CNS resident cells by differentiating patient-derived fibroblast induced pluripotent stem (iPS) cells in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Ultrasmall MEMS FTIR Spectrometer'.

assistant: **Objectives**

MEMFIS plans to show the feasibility of a miniature spectroscopic chemical sensor system based on a micro-FT-IR spectrometer. Based on mid-infrared spectroscopy offering analyte selectivity unrivalled by any other method and paired with the inherent sensitivity of a FT-IR spectrometer, such devices could be used in a wide range of applications, from air monitoring over in-line real-time process control to security monitoring. The spectrometer utilises innovative optical components based on MEMS-technology, leading to very compact and rugged spectroscopic devices with ultra-rapid scanning capabilities. The addition of a miniature source and a dedicated, highly sensitive detector completes the spectrometer module. Adding electronics and data evaluation and providing a standardised interface to various different modern IR probes, the MEMFIS spectrometer will present a very powerful spectroscopic sensor and a significant step forward in the smart spectroscopic sensors, microsystems technology and vibrational spectroscopy in general.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Phylogeny and systematics of the orb-weaver family Araneidae (Araneae, Araneoidea).' (2002-2006).

assistant: **Concept**

The spider family Araneidae represents one of the largest spider families. In spite of this, relationships within the family still remain doubtful. Our study will use morphological characters to reconstruct the phylogeny of Araneidae. The number of studied genera covers 50% of the family. New characters will be derived from extensive scanning electron microscopy. This will also generate an important SEM atlas for a wide selection of Araneid taxa, as well as representatives of 10 closely related families. Ex pected results: Illustrated catalogue of orb-weaving spiders, morphological dataset representing 50% of the family, phylogenetic tree based on morphology. An ongoing molecular project generate molecular data, which will be combined with the our results in order to generate a robust phylogenetic hypothesis for Araneidae based on all available data. Application: specifying relationships among the araneid genera, character system evolution within Araneidae (with reference to web and silk properties), will help material scientists developing artificial spider silk. The results of the project would enable a deeper insight into the differences of silk production of the different species, and thereby lead to a step forward in the applied research on natural silk pr oduction. The production of spider silk is environmentally friendly and completely biodegradable, and do not initiate immune response as implants [surgical threads]. The silk has better properties, than most of the biological and manmade materials. The hos t institute is one of the best places to carry out such studies, since equipment, specialist and experience in international knowledge networking are available here. The scientific host himself is specialized in araneid spider systematics and theoretical c ladi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of novel environmentally added-value surfactants and esters by biotechnological processes from fats and oils waste streams' in the context of a Seventh Framework call.

assistant: **Objectives**

Currently, different origin waste oils have been used mostly as animal feed, raw material for soap makers, and feed stock for fatty acid production. The existent patents and commercial processes to make fatty acids from waste oils always refers to hydrolysis and acidification steps using strong acids such as sulphuric or hydrochloridic acids, producing a mixture of fatty acids, inorganic salts, water, and other small components such as glycerine or phospholipids. Waste technical fats can provide a raw material basis for the production of surfactants. This amount of waste oil will serve as raw material for obtaining bio-surfactant and ester oils by biotechnological processes.This project Bio-SURFEST will develop two biotechnological processes at semi-industrial scale in order to produce two different classes of bio-products, bio-surfactants and ester oils (non useful for biodiesel production). Bio-surfactants will be produced by fermentative process and ester oils will be produced by enzymatic catalysis. Both biotechnological methods will use as raw materials or feedstock fry waste oil or technical fats.The main goal of the project Bio-SURFEST is to obtain high-value compounds such as bio-surfactants and ester oils from waste oils or technical fats, which represent a low value residue from a great variety of industries like hotels, restaurants, vegetable oil industry, biodiesel producers, etc. The aim of the present project is to determine suitable technical and economical production methods in order to obtain biosurfactants and other bio-products of high added value. Bio-SURFEST is focusing on the biotechnological optimisation of bio-products synthesis, using techniques such as fermentation and enzymatic catalysis. Using this approach, tailor-made bio-products will be o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Neurobiology of Decision-Making in Eating - Innovative Tools' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Nudge-it engages internationally leading experts in the neurobiology of motivational behaviour, the neuroscience of reward pathways, the neuroendocrinology of homeostatic regulation of appetite, experimental psychology, functional brain imaging, behavioural economics, and computational modelling. They will work together to develop new tools and approaches that can provide the evidence needed to inform effective policies on healthy eating. Effort will be focussed in four areas of particular importance for policy:i) early life experience: how the choices we make as adults are influenced by stress and poor nutrition in early life.ii) habitual eating behaviour: the life-long learning process and how it is moderated by homeostatic mechanisms;iii) impulsive choice behaviour:  the momentary choices we make to eat high energy or low energy foods, depending on hunger state and reward value, and upon price and availability;iv) the role of environmental context in decision-making processes: how day-to-day choices and preferences are affected by socio-economic status, stress, and mood.Development work will involve refinements of experimental approaches and tools in both human behavioural studies, neuroimaging, and translational animal studies. A focus will be on tools that provide ‘bridges’ that link understanding at different levels and in different domains, and which contribute to building predictive models with strong explanatory power that can contribute to policy formulation. A powerful strategy for dissemination of outcomes to relevant groups, including by a massive open online course, will ensure impact.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Participatory dEmocRacY that sCaLES' to be submitted under Horizon Europe.

assistant: **Abstract**

Civil society and public authorities from all levels of government are increasingly turning to digital democracy tools to improve citizens’ participation in democratic processes and the legitimacy of policy decisions. At the same time, digital democracy technology today is not yet fit to meet the lofty goal of providing an all-round democratic infrastructure that can re-empower citizens and make public administrations more relevant and responsive to the citizenry’s wills and needs. This is because digital democratic technology is currently developed and deployed while we still lack evidence-based methods to design, assess and validate it. We still lack the know-how to discern which specific technological solutions best foster inclusive, meaningful and scalable democratic participation, and under what conditions. PERYCLES tackles the challenge of developing such know-how, analyzing and testing platform designs on an open-source software for democratic deliberation that can be deployed at multiple levels of governance: from local, to national, to transnational. To do so, we develop a first-of-its-kind interdisciplinary approach to the design of digital democracy technology, which integrates methods and concepts from democratic theory, the social sciences and the computing sciences. The outcome of the project will be threefold: first, a set of methods to assess digital democracy solutions in a principled manner; second,  readily available open-source implementations of digital democracy solutions that meet the identified standards; third, a library of best practices and recommendations for the design and deployment of online participation platforms, targeting digital democracy practitioners, citizens and decision-makers.


**Keywords:** Digital deliberation, scalability, i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Integrated Prevention and Biocontrol Solutions for most devastating Citrus Pests'.

assistant: **Innovation**

CITRUSBUSTERS proposes an ambitious and efficient R&I initiative aimed at developing solutions tailored to address  Citrus pests with devastating impacts worldwide: Candidatus Liberibacter  (CL), its associated insect vector (T. erytreae) and Phyllostycta citricarpa (PC), considered priority and quarantine pest in the EU. With an  approach prioritising prevention, CITRUSBUSTERS will enlarge the IPM toolbox for high-value citrus crops by: (i) demonstrating the feasibility and benefits of smart tools for pathogen observation and early detection, enabling the prediction of future outbreak risks, based on co-culture models for CL and PC to provide solid knowledge on their spatiotemporal dynamics, technologies based on hyperspectral and LIDAR imaging, and predictive models through MLA linking soil health, vectors and plant parameters; ii) developing innovative tools, substances and agroecological practices to enhance plant resilience against biotic stresses  by means of DNA-free and genetic changes for breeding purposes and innovative extraction technologies for active molecules triggering immune responses in plants; and (iii) developing sustainable and safe biocontrol active formulations for improving crop health during cultivation, by means of encapsulated endolysins for CL, microbial antifungal substances for PC and dsRNA targeting T.erytreae. CITRUSBUSTERS will strenghten the abilities of stakeholders to respond to pest outbreaks relying on a solid multiactor approach for the co-creation of solutions and the assessment of environmental, social and economic impacts of the pests of the solutions, developing policy recommendations and best practices guidelines. This will ensure the adequacy of the proposed solutions and the wider acceptance of IPM strategies contributing to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Introducing deuterium for next generation chemical biology probes and direct imaging' (2021-2027).

assistant: **Concept**

The ideal microscopy experiment would take place in native cells without genetic engineering, with 3-dimensional resolution on the single molecule scale (<10 nm) by observing the endogenous molecule itself. I propose the introduction and use of deuterium (“deuterON”) as a general method for a multimodal approach, to i) synthesize a first-in-class deuterated  cyanine (Cy) fluorophore for super-resolution imaging, ii) to design and test deuterated, next-level photoswitches to restore vision, and iii) use these probes and deuterated drugs for direct and bioorthogonal, spectroscopic imaging. In particular, deuterated Cys will allow stochastic reconstruction microscopy (STORM) by using near infra-red light to break new ground in protein localization in live tissue, opening the gates for thick sample imaging (~100 m axial) with retained super-resolution (~20 nm). In addition, deuterated azobenzene photoswitches will be designed to finally reach the indispensable, and to-date unobtained light sensitivity to remote control neural signalling in vivo. Lastly, the use of ""label-free"" labelling and imaging will be explored with deuterated drugs to observe drug uptake and metabolism by utilizing the unique properties of the carbon-deuterium bond in Raman spectroscopy. Coupled to a confocal microscope, deuterated drugs will be tracked in native and live cells, without any genetic engineering strategies, and on the molecule of interest itself, reducing perturbations and artefacts to a minimum. This ground-breaking approach holds promise to be generalizable to Chemical Biology disciplines, and as an unconventional, yet attractive and powerful method to design and synthesize next generation small molecule probes. Developing a pipeline for these aims will be a game changer, with ramifi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Value added materials from organic waste sugars'.

assistant: **Innovation**

This project aims to showcase, at demonstration scale, the feasibility of producing and valorising second generation sugars derived from municipal solid waste (MSW). This MSW is composed of either mixed domestic residual waste or waste rejected from sorting and recycling processes (MRF rejects) and contains significant quantities of paper/card (lignocellulosic) based materials. The sugar will be utilised in the production of three bio-based products; 1) a thermoset bioresin used in the binding of mineral-wool insulation; 2) purified lactic acid (LA) for the commodities market; and 3) poly-lactic acid (PLA) and PLA/Fibre composite materials to be used in non-food contact applications within the fast moving consumer goods (FMCG), packaging, furnishings and construction sectors. The vision is to create a paradigm shift in industrial biotechnology products by establishing a novel approach based on the efficient use of low value mixed waste and the conversion of this material into value-added products. This project, titled ‘Value Added Materials from Organic waste Sugars’ (VAMOS) aims to produce competitive, sustainable, affordable and high-performance bio-based materials from low-value residual waste sugars.


**Keywords:** Lignocellulose, cellulosic sugars, bio-products, biomass
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Regulatory strategies and research needs to compose and specify a european policy on the application of the precautionary principle' (PRECAUPRI).

assistant: **Innovation**

The core of the proposed thematic network is to develop, in mutual consultations with researchers, administrators, policy makers and stakeholder groups, a scientifically sound, politically feasible, legally unambiguous and democratically legitimated concept providing a policy framework for the application of the precautionary principle, operationalising its application in different risk areas and ensuring specificity and predictability for all actors involved. This concept will be able to response to the challenges of uncertainty and ambiguity dealing with risks. First, different risk management approaches will be theoretically analysed deducing a policy proposal in which all-relevant risk evaluation criteria will be meet. Second, this policy framework will be empirically tested using chemical risk regulation in order to evaluate the theoretical and practical feasibility of the proposed policy framework Third, a series of four workshops involving the major stakeholders in the relevant risk arenas will be held in order to reflect the policy framework and to gain input for higher legitimacy. Fourth, the final approach of the policy framework will be articulated in scientific, politically relevant and legal terms, so that it can be used for policy making on a European level.