RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'SERS ultrasensitive universal sensing of proteins through cross-reactive sensor arrays' to be submitted under Seventh Framework.

assistant: **Abstract**

The goal of the present project is the development of novel nanostructured cross-sensor reactive arrays (CRSA) based on SERS and the different affinity of peptides and proteins to interact with different metallorganic complexes. This sensor concept will be universal for the ultrasensitive detection and identification of metallic cations and peptides/proteins.  Briefly, we shall fabricate micron-sized, composite nanomaterials as follows. Gold nanoparticles will be first deposited on silica or polymer microspheres via layer by layer self-assembly, and subsequent epitaxial growth will be carried out with silver (using novel methods recently developed in our lab) to generate discrete, highly SERS active surfaces. These composite particles will be functionalized with organic ligands with high affinity for metals (thiolated porphyrins and terpyridines). In a first step, quantitative multiplex ultrasensitive detection of metals will be aimed. In a second step, each microsphere coupled with one ligand and a given metal will be fabricated as a sensing element for the CRSA. These sensing elements will be organized into solid supports (the actual CRSA) and tested for the identification of different protein species, especially those related with pathogenic states or drug abuse, by combining SERS spectroscopy with chemometric methods (i.e. principal component analysis, hierarchical cluster analysis and partial least squares). The final product is intended to be mounted on a conventional glass slide with ability for drawing a rapid and accurate conclusion on the health condition of a patient, or environmental risk in a time scale of seconds.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A research agenda on implementation research in chronic care' (IMPLEMENT).

assistant: **Concept**

Europe’s population is growing older at a rapid pace, increasing the cost and threatening the future access and quality of healthcare in Europe. For a large part this is due to the rise of patients in need of chronic care. Healthcare in general, and chronic care in particular are in need of new ways of providing care, simply because the demand for chronic care cannot be met by the existing care infrastructure.At the same time Europe puts a lot of effort in funding research projects aimed at helping to build up innovative and sustainable healthcare systems in Europe. A surprisingly small number of outcomes of these projects are incorporated into actual care practice. This “implementation gap” keeps European citizens from benefitting from money spent on health research.This CSA therefore aims at taking implementation research (for chronic care) to the next level in order to enhance the scientific output and reap the benefits of its outcomes in everyday healthcare practice. This is done by combining knowledge from the organization of chronic care (Chronic Care Model) and knowledge from the young scientific field of implementation research.The main objective of this CSA will be to develop a Research Agenda for healthcare innovation implementation, focused on chronic care self-management support and delivery design. This will be done by performing an Assessment, involving 300+ experts on the knowledge and knowledge gaps concerning this topic. Next to the Assessment, a network (EU level and national) of institutions will be created, including science, industry, government, health care organizations, patients and professionals. This network will validate and later adopt the Research Agenda.The impact of this CSA is far fetching as it has the potential to influence the health o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A new tool to study in-situ micronutrient uptake and translocation in plants' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Zinc (Zn) is an essential micronutrient for humans and plants. The agricultural soils of large parts of the world are deficient in Zn, which causes Zn malnutrition to millions of people. This is of particular concern to economies depending on rice as major crop such as the developing countries in Asia. The development of Zn-efficient rice, able to tolerate low Zn levels and achieve a sufficient Zn concentration in grains, would have a very positive influence on the economy and health of the affected communities. However, our poor understanding about the mechanisms of Zn uptake, transport, and efficiency in plants poses a barrier to the breeders.The roots of grasses like rice exudate metal chelating agents in response to Fe deficiency, called phytosiderophores (PS). PS solubilise Fe and form PS-Fe complexes, which are efficiently taken up by roots. Recent results of the Weiss group at Imperial College London on Zn isotope fractionation in rice provided the first evidence that Zn uptake also depends on PS (Plant Cell Environ, 2010). This has been a major break through.We propose here to further investigate Zn uptake by rice in Zn-deficient soils. Our objectives are: a) to confirm the involvement of PS in Zn uptake, b) to determine the relative contribution of PS to total Zn uptake, and c) to examine the relationship between PS production and Zn-efficiency in rice, by comparing various rice strains differing in these two traits.The conclusions of the proposed research will help to focus the future work of the breeders on the most relevant mechanisms for Zn-efficiency in rice, and will be extensible to other metals and species of agricultural interest. The isotopic effects observed will have strong implications to understand plant contribution to Zn cycles. New isotope frac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Advanced integrated sensors' under Fourth Framework.

assistant: **Concept**

Rapid development has occurred over the past decade in the field of adaptive or smart structures and systems due, amongst other things, to the development and improvement of advanced data processing, actuators and sensors. Rather than conventional passive devices, smart structures and systems require advanced sensors with integrated functions: a data processing capability to increase the pre-processing of data; indirect measurement methods to acquire information on the state of the system itself and not only on single variables; a communication capability to exchange two-way commands and data with the possibility to interconnect with remotely accessible data monitoring systems using the Internet.The objective of this project is to develop new indirect sensors of advanced performance which can acquire dynamic system information (displacement, velocity and acceleration) at various locations on a structure so as to locally control the structure.The project is in progress. The hardware for the prototype sensor has been developed. The software for controlling the step-by-step motors for pointing the optical device has been designed and tested by simulation. Algorithms have been developed to analyse the dynamic behaviour of a structure and monitor its condition.Two types of smart sensors of the same conception will be developed, using optical beam and piezoelectric measurement principles. Raw data from the sensors will be processed locally so as to provide high level information on the state of the structure being controlled to a central processing unit and to external devices. The sensors will be interfaced with telecommunications networks (telephone and public data lines) in order to have the possibility to be able to control them remotely.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Role of angiogenesis in leukemia', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Our interest is to understand the role of VEGF expression and angiogenesis in leukemogenesis. Recently, emerging data is suggesting that in addition to promoting the growth and metastatic spread of solid tumors, angiogenesis may play an important role also in the pathophysiology of hematological malignancies. Clinical studies indicate that leukemia patients express high levels of pro-angiogenic factors such as VEGF and have increased angiogenesis in the bone marrow. However, these findings are mostly correlative and genetic proof that VEGF expression and angiogenesis support leukemogenesis is still lacking. Furthermore, the molecular mechanisms leading to high VEGF production in leukemia have not been elucidated. The transcription factor HIF-1a is the main positive regulator of VEGF expression. We therefore hypothesize that HIF-1a upregulation may cause high VEGF expression in leukemic blasts and propose to: 1) Elucidate the cause of VEGF expression in leukemic cells; 2) Study the effect of HIF-1a and VEGF overexpression on normal hematopoiesis; 3) Study the effect of HIF-1a and VEGF overexpression on leukemia onset and progression. We plan to achieve these objectives by an inter-disciplinary approach consisting of the analysis of in vitro experiments, in vivo data and clinical data. The expression of HIF-1a will be analyzed in leukemia clinical specimens and cell lines in correlation with VEGF levels, angiogenesis and disease progression. In parallel, in vivo studies in mice will address whether overexpression of HIF-1α or VEGF perturbs normal hematopoiesis and promotes leukemogenesis. These mouse models will be instrumental to test the efficacy of anti-angiogenesis and anti-Hif-1α inhibitors in the future. Funding of this proposal will foster the European reintegratio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Slow LIght Propagation in Photonic cRYstals (SLIPPRY)', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

SLIPPRY combines two very exciting topics in contemporary photonics research - slow light and photonic crystals - with the goal of designing compact and efficient slow light structures for all-optical data processing applications.Slow light will be the key to a new generation of all-optical processing devices including optical delay lines and buffers as well as ultra-compact, low power switches and modulators.To be of practical use, these devices must be broadband, and therefore require precise dispersion control in order to process high data rates and short pulses without signal degradation. Photonic crystals are thus the ideal platform for slow light structures, as they exhibit strong and highly adjustable dispersion behaviour as well as being able to operate over a wide bandwidth.One of the major shortcomings of this promising field is the lack of mature designs; while an ad hoc slow light design has recently been demonstrated in a photonic crystal modulator [Vlasov et al. Nature 438, pp.65-68, Nov 200 5], there is much to do in terms of bandwidth, suppression of higher order dispersion terms and tunability of the slowdown factor.SLIPPRY aims to address these issues through the following objectives,- comparative analysis of slow-light mechanisms in photonic crystals;- design and optimization of novel slow light structures;- optimization of an injector for broadband coupling to slow light modes;- design of active slow light devices in photonic crystals.We will achieve these objectives with the implementation of a numerical design and optimization program running in parallel with a world-class experimental research program.The design approach will incorporate semi-analytic methods, two- and three- dimensional numerical simulations and state-of-the-art numerical optimiz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Charting the process of getting forgotten within the humanities, 18th – 20th centuries: a historical network research analysis' in the context of a Horizon 2020 call.

assistant: **Objectives**

How did scholars get forgotten between the early 18th and the 20th century? To solve this question, the references to four humanities scholars (Dutch, English, French, and German) who worked on related fields, occupied similar posts, died in the first half of the 18th century and are little known today are to be tracked and compared by using historical network analysis (HNR) based on the tool NodeGoat. The sample of scholars is composed of Adrien Reland (1676-1718), Professor of Oriental Languages and Biblical Antiquities at Utrecht University;  Johannes Braun (1628-1702), Professor of Theology at Groningen University; Thomas Gale (1636-1702), Professor of Greek at Cambridge University; and Eusebè Renaudot (1646-1720), Member of the Academie Française and the Academie des Inscriptions et Belles-Lettres. References to them from an academic background are to be tracking during their lifetime as well as posthumously and to be entered in a structured NodeGoat database for HNR analysis. These references include quotations and citations as well as being explicitly mentioned in letters and in print, where print encompasses both journals and books. They are to be collected by search within digitized corpora as well as in library holdings and archival materials. The HNR analysis will then reveal patterns of reference and point to clusters where specific in-depth archival researches have to be carried out.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Roles of Homeoproteins in Lymphoid Organ Development' (HINLOD), addressing dissemination and exploitation.

assistant: **Impact**

Lymphoid organ development results from a complex interplay of genetically controlled molecular and cellular networks. While most of the molecular mechanisms underlying lymphoid organogenesis remain unknown, recent findings demonstrate that homeodomain transcription factors are essential to these processes. One such homeoprotein is Pbx1 that binds DNA with a subset of Hox proteins, including the Hox11 oncoprotein aberrantly accumulated in T-cell acute leukemia. Like Hox11, Pbx1 was originally isolated as a proto-oncogene in pre-B-cell leukemia. By using knockout mouse models, cellular and biochemical approaches, we demonstrated that Pbx1 and Hox11 loss of function mutations result in reduced spleen mesenchymal proliferation accompanied by spleen agenesis. Furthermore, we established a genetic network regulating spleen mesenchymal expansion and demonstrated the essential role of the Pbx1-Hox11 transcriptional pathway during spleen ontogeny. Although a few Pbx1- and Hox11-targets have been identified, the growth-related transcriptional networks orchestrated by these homeoproteins during lymphoid organogenesis remain mostly unknown. Our research objective is to perform a comprehensive search for direct Pbx1 and Hox11 growth-related target genes and de-convolute the global gene regulatory network governed by these homeoproteins during lymphoid organogenesis. We plan perform a comprehensive analysis to uncover genes differentially expressed in wild type and single Pbx1 and Hox11 mutant embryonic spleens. Next, our studies will focus on those direct downstream targets that are likely responsible for the cellular proliferation/differentiation defects observed in these mutant spleens. We will validate these potential targets by performing in situ hybridization and immunohistoch
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A Low Cost Active Debris Removal Demonstration Mission'.

assistant: **Objectives**

A huge amount of debris has progressively been generated since the beginning of the space era. Most of the objects launched into space are still orbiting the Earth and today these object and their by-products represent a threat both in space and on Earth. In Space, debris lead to collisions and therefore to damages to operational satellites. For both issues, a credible solution has emerged over the recent years: actively removing heavy debris objects by capturing them and then either disposing them by destructive re-entry in Earth atmosphere or disposing them in graveyard orbits. The REMOVEDEBRIS project aims to demonstrate key technologies for ADR in these three main domains by performing in-orbit demonstrations representative of an ADR mission. The specific key technologies that will be demonstrated as part of this project are: (i) Capture technologies such as  nets and harpoons (ii) De-orbiting technologies such as electric propulsion and drag augmentation (iii) Proximity Rendezvous operations technologies based on vision-based navigation. The technology demonstrations will be carried in orbit using a micro satellite test-bed, a world’s first. The micro satellite will carry the ADR payloads together with 2 deployable nanosatellites (CubeSats). Through a series of operations, the nanonsatellites will be ejected, re-captured, inspected and de-orbited, thereby demonstrating the ADR key technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Decision support for problem solving on the shop floor to promote best practice in quality manufacturing' under Fourth Framework.

assistant: **Concept**

This project is aimed at the provision of IT support for practical decision making for solving shop floor problems in SMEs by encouraging a self-help approach. This IT decision support system (DECIDE-IT) will consist of a structured framework, with information support for the performance of problem diagnostics in the areas of production and quality problems. The information will be in the form of guidance incorporating knowledge from key personnel, experienced operators, existing company information systems and experts to apply to problems.It is expected that this pilot experiment should show a great improvement in productivity (less scrap, downtime and operational problems) for the participating SMEs. The results of the project should encourage other SMEs to benefit from the adoption of IT support.It is widely considered that the effective control of production, quality and maintenance are crucial to the survival of industrial SMEs, with quality costs typically in the range of 20% to 40% of gross revenue with production problems and downtime adding to cost. SMEs typically expend too many of their resources firefighting and problem solving. SMEs also tend to rely heavily on a few key personnel causing problems due to overwork, or when key staff leave the company with their unique knowledge.The consortium consists of 5 SMEs, from two different sectors, and two best practice coordinators. The SMEs have the common aim of investigating the use of IT to support their decision making process with particular emphasis on the integration of knowledge from several functions in order to solve production and quality problems. The 2 facilitating companies will provide the DECIDE-IT framework, the production and quality control expertise and assistance with the SME investigations. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'INNOWAY Key Account Manager and Innovation Specialists Services – NOREIC 2020-2021' to be submitted under Horizon 2020.

assistant: **Abstract**

The specific objectives of the NOREIC project is to enhance the innovation management capacity of Norwegian SMEs in 2020 and 2021 by reducing barriers to innovation and to ensure that more great ideas will reach the market. The two distinct types of services under this consultation, a) Key Account Management under the EIC pilot and its successor  b) Services to enhance the innovation management capacity of SMEs will in 2020 and 2021 be offered as an integrated part of the general support services of the Enterprise Europe Network Business Cooperation Centre (BCC) in Norway. The services will not be delivered to the same client(s) in parallel.


**Keywords:** EIC pilot, Innovation management, SME