RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Targeting 5-lipoxygenase in the context of Acute Myeloid Leukemia' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Drug efficacy is cornerstone for successful drug discovery programs. Considering that, on average, FDA-approved drugs modulate dozens of off-targets it remains imperative to find strategies to overcome adverse drug reactions correlated with pernicious polypharmacology. In fact, several chemical entities displaying promising anticancer are discontinued from drug development pipelines due to narrow therapeutic windows in pre-clinical models. Here, we propose the development of antibody-drug conjugates exploring the unique bioactivity profile of the naphthoquinone natural product-lapachone (Lp) against acute myeloid leukemia (AML), an unmet medical need. Using a machine learning method, we disclosed Lp as an allosteric modulator of 5-lipoxygenase (5-LO), correlated its anticancer activity with 5-LO expression in blood cancers and showed its efficacy in a disseminated mouse model of AML.In this project, a comprehensive investigation of novel means for the targeted delivery of Lp to leukaemia cells is sought after, considering both the promising bioactivity profile but also the significant toxicity in untargeted dosage forms. We apply state-of-the-art synthetic medicinal chemistry to design and access cleavable linkers, and site-specifically conjugate Lp to an anti-IL7R antibody, a validated biomarker in AML and other leukaemia’s. We aim at employing biophysical and chemical biology approaches to validate quantitative and fast release of Lp with accurate spatiotemporal control in in vitro disease models. Finally, we will validate the deployment of the constructs through preclinical in vivo models of AML. We foresee broad applicability of the developed technology, which may have profound implications in drug discovery. Upon successful completion of this research program, we h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Challenging the fundamental limit of angular dispersion by hybridizing light and matter' to be submitted under Horizon Europe.

assistant: **Abstract**

Interference is one of the most fundamental phenomena in optics, allowing us to confine, filter, manipulate and steer light with exquisite precision. It is at the core of thin-film optics and nanophotonics, two areas of science that catalyse major scientific and industrial advances. One fundamental property of optical interference, however, constitutes a major limitation – the characteristics of any interference-based structure depend on the angle between the light wave and the structure itself (e.g. the transmission wavelength of optical interference filters shifts strongly when the angle of incidence changes). So far, this ‘angular dispersion’ effect remains a largely unchallenged fundamental limit in optics. HyAngle now proposes a novel strategy based on hybridizing light and matter states to break the angular dispersion limit. By tuning the coupling strength and offset between a photonic resonance formed by optical interference and the electronic resonance causing optical absorption in a material, I expect to be able to realize interference-based optical devices with spectrally sharp and angle-independent transmission, reflection and emission. We will explore the physics, potential and limitations of this approach by developing and studying dispersion-free optical filters, colour converters and LEDs with narrowband spectra. We will then pursue two specific applications, namely hyperspectral cameras and bio-implantable lensless fluorescence microscopes, where our devices will enable major advances in capability and unprecedented performance in deep tissue applications.Our devices use organic materials that can be readily processed by high-throughput vacuum deposition and even from solution. The amorphous nature of these materials renders them intrinsically compatible
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Intelligent Memories that Perform Inference with the Physics of Nanodevices' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Cognitive tasks are increasingly necessary in modern electronics. The energy efficiency of associated algorithms, which rely on abundant stored parameters, is severely limited by the separation of computation and memory elements in conventional computers. In NANOINFER, I will directly address this challenge by developing intelligent memory chips that natively perform both memory and computing functions, using CMOS and emerging nanodevices. These chips will perform modern Bayesian inference algorithms, which allow cognitive-type reasoning. The project includes theoretical investigations as well as intelligent memory chip designs, which will be supported by proof-of-concept experimental demonstrations. The proposed architectures, based on spintronic and memristive memories, will maximize energy efficiency by leveraging the complex physics of these emerging devices for inference operations and the storage of model parameters, and by minimizing exchanges between computation units and memory. Inference will be performed using sampling algorithms that allow tackling difficult problems and are robust to nanodevice imperfections. The inference circuits will be composed of digital CMOS logic as well as spiking neurons circuits. Two standard Bayesian approaches will be employed to enable learning, permitting highly adaptive systems. Preliminary results on a system that performs naïve Bayesian inference have validated this concept and its use with novel memory technologies. NANOINFER will resolve critical interdisciplinary challenges to permit intelligent memories to perform non-naïve tasks, ensuring a correspondence between device physics and Bayesian concepts while maintaining a fusion between computation and memory. This project will deepen our understanding of novel memory tec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Twinning to develop ELTE's research and innovation capacity in quantum reservoir computing' under Horizon Europe.

assistant: **Concept**

QUEST's primary goal is to amplify the scientific prowess and innovative capabilities of Eötvös Loránd Tudományegyetem (ELTE) alongside its esteemed Twinning partners: Linköpings universitet, Loughborough University, Aalto University and Intelligentsia Consultants Sarl. They collectively aim to create a quantum reservoir computing (QRC) system leveraging silicon carbide (SiC) defect qubits. Over three years, QUEST plans to roll out a research and innovation strategy centered on five core objectives, each associated with eight interrelated work packages.Objective 1 is geared towards pioneering research to construct a QRC system based on SiC defect qubits. This avant-garde technology could potentially enhance computational speed and diminish power usage by over 100 times compared to traditional machine learning models.Objective 2 emphasizes knowledge-sharing between ELTE's seasoned researchers and the Twinning partners, facilitated via short-term staff exchanges, seminars, and training sessions, all complementing the research from Objective 1.Objective 3 focuses on nurturing the career aspirations of early-stage researchers associated with both ELTE and the Twinning entities. They propose strategies like brief and intermediate exchanges, workshops, summer training sessions, and a collaborative PhD scheme.Objective 4 aims to refine ELTE's administrative and managerial proficiency for European R&D initiatives. Specifically, this entails enhancing the expertise of ELTE’s Education Support Office and Research Support Office in aspects like project management, proposal drafting, intellectual property management, and scientific communication concerning European R&D funding programmes.Objective 5 is dedicated to bolstering the research stature and academic credibility of ELTE an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A comprehensive method for medium-term analysis and forecasting (CMAF) of global monthly prices of agricultural commodities' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

This is a proposal for a comprehensive methodology for medium-term analysis and forecasting (CMAF) of monthly global prices of agricultural commodities. The project will create a tool based on this methodology, which provides a detailed explanation of the forecasts and enables their complete interpretation. Integrating eight econometric and machine learning (ML) methods, CMAF will combine the joint effects of over 100 possible variables. In addition, it will consider the inclusion of additional potential explanators for specific needs or purposes. It will use different cross-validation techniques to avoid a priori research assumptions and realistically captures these complex relations. First, the learning process begins with comprehensive stationary and causality tests, which detect the nature of each possible variable and its suitability to serve as an explanatory factor in the changed agricultural commodities prices. Secondly, it performs a retrospective analysis while considering many variables from three different groups: market fundamentals, financial and climatic. Thirdly, it uses relative importance analysis to reduce the number of features and include only those most essential for an accurate agricultural commodities price forecasting performance. Lastly, it provides a detailed and intelligible visual interpretation of the results and the learning process in a straightforward manner to serve even those with no academic or financial background. CMAF will be easily trained using publicly available data and will be made available open source. It will also be adaptable and could be applied to forecast the prices of various agricultural commodities, irrespective of budget, language or other skills constraints. The outcome will be a powerful and broadly applicable too
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Breakthrough Water Vapor Driven Turbo-Compression System for Sustainable, Thermal, Advanced Cooling'.

assistant: **Objectives**

STAC Technology has designed and developed a breakthrough system that can solve a major sustainability issue surrounding the future of space cooling; how to grow access to this essential need while diminishing its terrible impact on the environment. Our patented water vapor driven turbo-compressor technology powers a potentially near-zero-emission, plug-and-play refrigeration system (DEOS) that produces a pumpable ice slurry with 7x the cooling capacity of existing solutions, delivering 40% reduction in greenhouse gas (GHG) emissions, energy consumption reduction by 10% compared to NH3 cooling and heating and 62% compared to HFC-cooled AC units. Our system has been designed to exceed the performance and efficiency standards of current District Cooling (DC) and District Heating & Cooling (DHC) networks, bolster returns from existing networks, accelerate growth plans in underserved markets and deliver more sustainable cooling.


**Keywords:** District cooling,Energy management,Environmental and Green Technologies,Energy Efficiency,Engineering and technology,Design innovation,ice slurry,water,refrigerant,Automation and control systems
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrated European Industrial Risk Reduction System' in the context of a Seventh Framework call.

assistant: **Objectives**

Current practices in risk assessment and management for industrial systems are characterized by its methodical diversity and fragmented approaches. In retrospect these risk and safety paradigms resulted from diverse industries driven and limited by available knowledge and technologies. A change based on industry driven R&D work is needed. At present the European Industry recognised their obligation to reconsider their risk and safety policies, having a more competitive industry and more risk informed and innovation accepting society in vision. Therefore the large collaborative project IRIS is proposed to identify, quantify and mitigate existing and emerging risks to create societal cost-benefits, to increase industrial safety and to reduce impact on human health and environment. The project is led and driven by the industry to consolidate and generate knowledge and technologies which enable the integration of new safety concepts related to technical, human, organizational and cultural aspects. The partnership represents over 1 million workers. The proposed project relates to strategic research topics defined by ETPIS and ECTP and is underpinning relevant EU policies on industrial safety.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced Innovation Support Services for SME' (AISS4SME).

assistant: **Innovation**

The AISS4SME project aims at offering new services to enhance the innovation management capacities of luxembourg SMEs. 2 target group of SMEs will be address : first, the beneficiaries of the SME instrument and, second, innovative SMEs. This proposal is a response to the Consultation of Enterprise Europe Network partners on the work programme for 2017-2018 H-2020 activities H2020-EEN-SGA2-2017-2018 “Enhancing the innovation management capacity of SMEs” in the Enterprise Europe Network”, and concerns the set up of coaching and mentoring services for SMEs. It’s our confidence that the AISS4SME proposal is 100% in line with the challenge and scope defined by the EC. Moreover, by pursuing the defined strategic objectives, the project will automatically produce the expected overall impact of: • Enhancing the commercial potential and impact of SME participation in the dedicated Horizon 2020 instrument by ensuring that the project is aligned with and developed as an integral part of the company's innovation strategy, • Achieving tangible organizational change and improved results, • Improving the skill's levels of managers, leaving a legacy such that the SME is better able to overcome the barriers to growth post-Horizon 2020 participation.


**Keywords:** Innovation Management Capacity, Key Account Management, SMEs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Role of non-coding rnas in gene silencing and parental imprinting' in the context of a Fourth Framework call.

assistant: **Objectives**

Parental imprinting of mammalian genes is an important genetic principl with far-reaching consequences for development and genetic disease. The mechanism of imprinting is not fully understood, but it has been shown that DNA methylation is involved. An intriguing feature is the presence of genes for non-coding RNAs within all imprinted loci examined so far. They are thought to play a role in gene silencing. Here I propose, to develop in vitro tests to study the influence of the H19 non-coding RNA on the methylation pattern and silencing of the Igf2 gene whose in vivo expression is strongly related to the Hl9 expression. This will lead to identification of the putative active site(s) of the Hl9 RNA. Using gene targeting in mouse ES cells, this active site could then be deleted from the endogenous Hl9 gene to investigate its role in vivo. Finally, this will lead to important insights into the mechanism of imprinting, and into disease mechanisms associated with loss of imprinting (the Beckwith-Wiedemann syndrome in this case). This project will give one valuable training in molecular genetics and ES cell manipulation, building on the skills I have gained in my doctoral training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Benjamini-Schramm approximation of Groups and Graphings'.

assistant: **Innovation**

Large graphs have become central objects in many fields in the last couple of decades: in neural sciences, network sciences (WWW, graph of webpages), social sciences (Facebook) and molecular biology.  The standard way to handle large networks is Property Testing: We check only a small number of vertices picked randomly, and we try to learn the properties of the huge graph from this random sample. The general questions of the proposal are the basic problems in all of these fields: Which properties of a large graph are testable? How can we approximate large graphs by small ones?The proposal is at the crossroads of the following three fields:1. Sparse graphs and computer science2. Dynamics and measured group theory3. Graph limit theoryWe expect a boom in the fields of this proposal similarly to the fields related to Szemeredi's theorem. We expect more applications, since sparse graphs appear more often in real life. Recent breakthrough results in computer science play an important role in the methodology. The proposal focuses on three problems in the research frontier addressing the above phenomena:1. The construction of a nonsofic group2. The measurable version of the Lovasz Local Lemma3. The dynamical von Neumann problemKun is an expert in the fields of the proposal. After completing his PhD at the Eotvos University he moved to the USA. He plans to return to Europe after six years at top institutions in North America. The Alfred Renyi Institute is a well-knowncenter in the fields of the proposal, and one of the leading institutions in discrete mathematics. Kun plans to work with Tardos, the scientist in charge, and Abert, Pyber, Szegedy and Szemeredi at the host.The project would enrich the mathematical culture of Hungary and the ERA, and lead to mutually beneficial, lon
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European social survey, round 2 - monitoring attitude change in europe' (MACE) under Fifth Framework.

assistant: **Objectives**

The first round of the European Social Survey (ESS), the forerunner of this proposal, was funded under the 2nd Call of Framework 5, and co-funded by the European Science Foundation and 20 national academic funding agencies. The culmination of five years of background work, the project is designed to create a new, academically-driven, uniquely rigorous time series which will document and help explain hitherto inadequately-charted trends in European attitudes and underlying values. Thanks to this investment from national and international sources, the project has quickly established a remarkable momentum and a European-wide infrastructure. It now seeks to consolidate and sustain this infrastructure in a planned second round two years after the first. As a demonstrable practical forerunner of the European Research Area at work, the project will provide an invaluable substantive and methodological input into European governance.