RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Resources and Services Virtualization without Barriers' (RESERVOIR), addressing dissemination and exploitation.

assistant: **Impact**

The goal of the RESERVOIR project is to increase the competitiveness of the EU economy by introducing a powerful ICT infrastructure for reliable and effective delivery of services as utilities, analogously to electricity and telephony.  This infrastructure will support the setup and deployment of services on demand, at competitive costs, across disparate administrative domains, assuring quality of service.  In doing so, RESERVOIR will lay a foundation for a service-based European online economy, where services - which have become critical to our business environment - are transparently, scalably and flexibly provisioned and managed for the benefit of businesses and citizens.   <br/>The prime deliverable of the project will be an architecture and a reference implementation of a service-oriented infrastructure (SOI) which – building on open standards and new technologies – will provide a dependable framework for delivering services as utilities. We will demonstrate how this infrastructure supports the deployment of complex service scenarios that are not otherwise supported by today's technology. We aim to achieve quantified and significant improvements in service delivery productivity, quality, availability and cost.<br/>From a scientific standpoint, our work will contribute to the state-of-the-art by: <br/>\tSignificantly advancing virtualization and grid technologies and deeply integrating them, thereby creating a basis for the next generation SOI, where services and their associated resources are effectively delivered without boundaries" of geography and configuration.<br/>\tDeveloping service management technology capable of exploiting the strengths and addressing the challenges presented by our infrastructure, e.g. monitoring service execution and resource utilizat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Cytoskeletal regulation during mitosis in the Retinal Pigment Epithelium' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

This proposal seeks to elucidate how the actin- and microtubule-binding motor protein Myosin7A organises the cytoskeleton during Retinal Pigment Epithelial (RPE) cell division. While the human retina has long been thought to have limited self-repair ability, new research shows it has regenerative potential, with RPE stem cells capable of undergoing cell division and repairing tissue. Unlocking the molecular mechanisms of this regeneration could revolutionise treatments for retinal degenerative diseases. However, due to the unique microenvironment and protein expression profile, the molecular mechanisms controlling RPE cell division are still unclear. Preliminary experiments suggest a previously unknown role for Myosin7A in the organisation of the mitotic spindle specific to RPE cells. In this project I aim to build upon these findings by integrating my expertise in epithelial and cytoskeletal dynamics with the host lab’s advanced ophthalmologic research pipelines. Through a bottom-up approach, I will investigate how Myosin7A influences cytoskeletal dynamics and mitotic spindle organisation, guided by the following objectives: In Objective 1, through a combination of advanced molecular techniques and high-resolution microscopy, I aim to elucidate how Myosin7A influences both microtubule and actin dynamics in human ARPE19 cells. Leveraging these findings, in Objective 2, I will systematically analyse the stages of mitosis to uncover the mechanisms underlying mitotic defects caused by Myosin7A depletion, shedding light on its role in mitotic spindle organisation. To contextualise these discoveries, in Objective 3, I will translate the results to iPSC-derived retinal organoids, providing a physiologically relevant model to better understand Myosin7A's function within the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of an immunotherapy for breast cancer based on dendritic cells by developing and comparing different types of tumor specific immunogens' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project aims for the development of an effective immunotherapy for breast cancer, based on dendrite cell vaccines. This includes the generation of dendrite cells, the production of breast cancer related immunises, the development and improvement of new strategies for enhanced antigen presentation the in vitro evaluation of immune response using patients T-cells and mouse models and the transfer of the most successful approach to GMP as well the design of a clinical trial. The project requires collaboration between medical oncologists and scientists with expertise in cancer immunology, dendrite cells therapy, biotechnology, basic molecular biology and glycobiology. Cancer vaccines based on dendrite cells are the focus of attention worldwide and the leading company in Europe; IDM is a participant in this project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'A new device to detect quickly and friendly Ochratoxin A and other myco-toxins in feed, food and beverage'.

assistant: **Concept**

Objective of this proposal, called DEMOTOX, is to prove the viability of results obtained as outcome of the OTASENS Project, which was funded within the program “Research for SMEs; FP7–SME–2008–1, Grant Agreement No. 232245. The results obtained in the OTASENS Project offer a potential economic advantage to the partners, because they give them possibility to develop a simple, innovative device, portable, sensitive, to detect ochratoxin A (OTA) and other mycotoxins. Therefore, the SMEs leading DEMOTOX are committed to taking the laboratory prototypes developed in OTASENS to a commercial product, a simple system able to signal presence of myco-toxins in food, feed, beverage, over the law limits. Preliminary information show that the system developed in OTASENS has great market potential; a short market analysis is anticipated both from the point of view of the instrumentation of analysis required and of the sectors interested in the field of food and feed safety. A well- developed market strategy, based on business case and business plan, will be carried out during this Project in order to launch the innovative product into the international market. Manufacturing of this innovative device will allow the participating SMEs of the DEMOTOX Consortium to become more competitive; moreover, taking into account that the RTD Performers in OTASENS will be partners in this Project, success of the Demonstration activity in the DEMOTOX Proposal will enhance links between SMEs and R&D group through a strong campaign of training and dissemination. Two  detection strategies, one based on chromatographic measurements and the other based on immunoassays will be produced to allow screening of a large number of samples in a short time and indicate which of them are contaminated. At least 20
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development of a high-performance nanofluidic osmotic diode for efficient voltage-driven desalination and pumping' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Water scarcity is an urgent global challenge and one of the greatest societal threats posed by climate change. Despite growing concern over water availability, processes to expand water supplies beyond current freshwater reserves, such as desalination and wastewater reclamation, still suffer from insufficient rejection of contaminants and relatively high energy requirements. Nanofluidic technologies have the potential to revolutionize water treatment owing to the extraordinary transport characteristics of confined pores. The objective of the proposed project is to develop a new nanofluidic device—the osmotic diode—for voltage-driven desalination and pumping. To control water and ion transport, the device requires a nanopore with tailored asymmetric surface charge. An applied voltage difference can be used to drive water molecules through the nanopore while ions are rejected, desalinating source water. The system is advantageous because permeability and selectivity properties can be tuned based on nanopore characteristics, and it offers improved versatility compared to existing desalination processes. To realize the technology, the proposed work will (i) fabricate a single pore osmotic diode with tailored surface charge, (ii) characterize water transport across such a nanopore utilizing ultrasensitive flow measurement techniques, and (iii) use knowledge from the single pore system to scale up performance to many-pored membranes. Throughout the project, advanced modeling techniques will be utilized to fundamentally understand transport and further optimize the system. The proposed research action will address Horizon 2020 Societal Challenges related to water security and resource efficiency while advancing the field of nanotechnology through the development of new fabrica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'QCL Frequency COMBs: INternational exploitation Analysis and commercialisation' to be submitted under Horizon 2020.

assistant: **Abstract**

Optical Frequency Comb (OFC) are laser devices which emit light in a wide spectrum consisting of equidistant peaks in frequency space. The FET project “Qombs” made major advances in high performance of the OFC by employing quantum cascade laser sources (QCL) able to operate over all the mid-IR and far-IR region of the spectrum. However, the applications of the QCL-OFC are for the moment rather limited and all potential markets remain hidden.  In that view, QombINA project aims in the development of a solid exploitation strategy for Frequency Comb lasers, which are a result of QOMBS project, aiming at the commercialisation of said devices. In that view, during QombINA project, a set of targeted activities  aiming at showcasing the concept of QCL Frequency Combs to wider market applications will be pushed forward, while most promising applications and potential markets will be achieved through detailed business and marketing plans, respectively.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Onion peeling machine' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Currently, peeling of onions in the onion industry takes place either manually (mostly performed in countries with low-wages). The current semi automatic machines have a number of shortcomings. Firstly, human operation still is required which brings additional costs to the onion industry of 17,500 Euro per annum for each required labourer. Secondly, the semi-automatic machines could only be adjusted to fixed onion, leading to quality losses and/ or unnecessary scrap. This RTD project is proposed to research, develop, build and test a machine that is able to peel an onion fully automatically. Critical aspect is whether it is possible to recognize the head and tail of the onion. The idea is to perform recognition by a camera system, which also will be used to measure the dimensions of the onion. This information is used to fine-tune the machine peeling mechanism, thus ensuring an optimal peeling operation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The enzymes of the pantothenate - vitamin b3 - biosynthesis - mechanistic studies and potential synthetic applications' (1994-1998) under Fourth Framework.

assistant: **Objectives**

This fellowship application is for funds to study the mechanism of two of the enzymes of the pantothenate biosynthesis, ketopantoate hydroxymethyl transferase (KPHMT) and aspartate decarboxylase (ADC). The group of Prof. Abell has cloned, overexpressed and purified both of these enzymes. The specific aims of this project are detailed in the following points: 1) Processing of the protein ADC. ADC is translated as a proenzyme which is cleaved at a Gly24-Ser 25 bond to yield an A subunit with a pyruvoyl group attached and a B subunit. The autocleavage in vitro is not chemospecific, which is unlikely to be physiologically desirable, suggesting that there are more factors involved in this processing in vivo. We plan determine to what extent the processing of the protein is related to its activity. Assaying the formation of the pyruvoyl group and enzyme activity, and correlating both of them with the amount of cleaved protein quantified by ESMS and SDS-PAGE should indicate if the activity is proportional to the processing of protein. 2) Mechanism of processing of ADC. We will attempt to ascertain this mechanism by labeling with 18 O the side chain of the serine involved in the cleavage and measuring by ESMS the distribution of 18 O between the A and B chains. 3) Mechanism of reaction of ADC. We want to study the stereochemistry of the reaction carrying it out in D 2 O and looking at the deuterium incorporation. In addition we plan to study the inhibition of this enzyme by irreversible inhibitors and its inactivation by the substrate L-aspartate. 4) Mechanistic studies on KPHMT. Little is known about the mechanism of conversion of a-ketovalerate (the substrate of KPHMT) to ketopantoate. We want to carry out a kinetic characterization of the reaction, pH-rate profile, substrate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Extreme-scale Mathematically-based Computational Chemistry' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Molecular simulation has become an instrumental tool in chemistry, condensed matter physics, molecular biology, materials science, and nanosciences. It will allow to propose de novo design of e.g. new drugs or materials provided that the efficiency of underlying software is accelerated by several orders of magnitude.The ambition of the EMC2 project is to achieve scientific breakthroughs in this field by gathering the expertise of a multidisciplinary community at the interfaces of four disciplines: mathematics, chemistry, physics, and computer science. It is motivated by the twofold observation that, i) building upon our collaborative work, we have recently been able to gain efficiency factors of up to 3 orders of magnitude for polarizable molecular dynamics in solution of multi-million atom systems, but this is not enough since ii) even larger or more complex systems of major practical interest (such as solvated biosystems or molecules with strongly-correlated electrons) are currently mostly intractable in reasonable clock time. The only way to further improve the efficiency of the solvers, while preserving accuracy, is to develop physically and chemically sound models, mathematically certified and numerically efficient algorithms, and implement them in a robust and scalable way on various architectures (from standard academic or industrial clusters to emerging heterogeneous and exascale architectures).EMC2 has no equivalent in the world: there is nowhere such a critical number of interdisciplinary researchers already collaborating with the required track records to address this challenge. Under the leadership of the 4 PIs, supported by highly recognized teams from three major institutions in the Paris area, EMC2 will develop disruptive methodological approaches and pub
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Support to the Vice-Presidents of the ERC Scientific Council 2019' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The European Research Council (ERC) provides a competitive platform for investigator-driven frontier research at the European level. It is led by a Scientific Council (ScC) consisting of 21 eminent scientists and their President, and it is this council that independently establishes and oversees theERC's scientific management and the implementation of its Work Programme. This project aims to support the ERCVice-Presidents, who act on an honorary basis, in the efficient and timely achievement of the ScC's goals in 2019.This project will provide local administrative and advisory support to the three ERC Vice-Presidents.The staff supported by this project will provide analysis of the output of the ERCand the ScC to the Vice-Presidents, preparatory work for the meetings of the ScC, support with scientific outreach and representation, as well as maintaining a clear and efficient channel of communication between the Vice-Presidents and the ERC's Executive Agency. A key duty of the Vice-Presidents is maintaining the integrity of the ERC's evaluation panels, and the staff supported by this grant will facilitate this by providing detail information and analysis of potential panel members to the Vice-Presidents to allow them to take informed decisions on recruitment.The staff will also coordinate the invitation of new panel members and communicate with them during the recruitment process.The impact of the project will be to ensure the efficient and well-managed operation of the ScC. This support is required, as the duties of the Vice-Presidents demand a considerable portion of their time. By allowing the Vice-Presidents to effectively and efficiently perform their duties, this project will contribute significantly to the continued implementation of the ERC under Horizon 2020.


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system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ADVANCE IRIS RECOGNITION IN MOVE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Critical infrastructure protection topic 7: SME instrument topic: “Protection of Urban soft targets and urban critical infrastructures. DRS-17-2014-1.The scope of this topic is focused to cover high throughput screening of people including the ability to screen them in reasonably real-time as people approach entrances to buildings or enter public transportation system. The objective of the project is a new recognition system in buildings, to improve the security and the speed of the recongnition in order to make this more comfortable for users and more efficient for the management of the building.The system under development contributes to solve the current problems of recognition and access control above (slow recognizing and therefore access and consequent generation of queues, uncomfortable process for users of different facilities, inability for controlling certain areas and control degradation itself caused by volume of movements to be controlled, tiredness or lack of human resources), taking advantage of the business opportunity identified.