RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Trial Action for Digital Object Exchange' (TRADEX) targeting Fifth Framework.

assistant: **Abstract**

Even though a strong effort has been recently devoted to digital object transfer issues, there is still the lack of common consensus and the need of standardisation in this area. The main objective of TRADEX is to set up a trial for assessing solutions resulting from recent research activities on digital object exchange, with the aims of enhancing the marketing of tradable multimedia related to cultural heritage.TRADEX will carry out an international co-operation for the establishment of a world-wide common working platform (Japanese actors are involved), deploy the results of European research in the field of electronic treatment of IPR, foster the penetration of methodologies and technologies towards cultural institutions and governments, contribute to create a critical mass of buyers and sellers of cultural digital objects, identify solutions to be recommended to the involved governments as technical annexes to national directives.Work description:TRADEX restricts the trial domain to the on-line multimedia object transfer. At technological level, TRADEX will first consider available copyright marking technologies for solving the illegal copying and proof of ownership problems in the context of multimedia objects.TRADEX will focus on the convergence on common criteria for:- content fidelity preservation;- robustness to attack;- applicability to audio, image, and video data, including synthetic objects.TRADEX assumes the e-commerce scheme based on digital signature and public key encryption. This introduces further points of which common background should be agreed, such as the integration of digital signature and watermarking techniques, and Digital Object Identification and ownership certification.Thanks to the involvement of Smart Card producer, new-generation smart
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Study of proteins involved in oligodendrocyte process extension that regulate axon-glia interactions'.

assistant: **Objectives**

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). The importance of myelination is illustrated by the neurological consequences caused by demyelination, the process or state resulting from the loss or destruction of myelin such as in multiple sclerosis (MS), the most frequent CNS chronic demyelinating disease. Failure of remyelination is thought to be the major cause of MS disease progression and may be caused by the incapacity of oligodendrocyte progenitor cells (OPC) to differentiate into myelin-competent oligodendrocytes. Rho GTPases regulate signaling pathways involved in actin cytoskeleton, microtubule dynamics, cell polarity, membrane trafficking and gene transcription. They are expressed by oligodendrocytes and are likely to be involved in some of the events leading to myelination, but their role in this process is still poorly investigated. Additionally, in the context of MS and remyelination, the modulation and/or activity of such molecules in oligodendrocytes has still not been addressed.Therefore, we intend to characterize the network of molecules associated with Rho GTPase signaling responsible for regulating oligodendrocyte cell spreading, process extension, and formation of the highly ramified processes typical of differentiating oligodendrocytes using proteomics and interference RNA-based functional assays in primary cultures and in axon-oligodendrocytes co-cultures. Additionally, we want to evaluate if and how the expression and activities of such molecules are affected by the inflammatory milieu, in vitro and in vivo using experimental autoimmune encephalomyelitis (EAE) animal models. This knowledge will allow us to gain valuable insight into the mechanisms that regulate the establishment and stabilization of oligodendrocyt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Aurora A mouse models: new tools for the study of mitosis deregulation in cancer' to be submitted under Sixth Framework.

assistant: **Abstract**

Correct chromosome segregation is an essential process in the mitotic cell division. This still poorly understood process occurs during mitosis and has recently been associated with cancer. The mitotic spindle is a complex structure regulated at multiple levels including the control of its formation by phosphorylation. Among the mitotic kinases, the Aurora family of proteins have specific roles in this process. Aurora A is a mitotic kinase commonly deregulated in human cancer and whose over-expression has been shown to induce mitotic defects, aneuploidy, and oncogenic transformation in vitro. However, the exact function of this protein is not well understood and we still do not know many of its substrates.In this project, we will develop a mouse model of Aurora-A inactivation by generating a conditional knock out for the Aurora-A (Stk6) gene. In addition, to investigate its role on tumour development and progression, we well generate a knock in mouse that will express a non-degradable form of this protein, and therefore resistant to its proteolytic degradation in mitosis. Both mouse models, for loss-of-function and gain-of-function, of Aurora-A will provide essential reagents to understand not only the biology of mammalian Aurora-A in vivo, but also for a better knowledge of the role in cancer of this protein, one of the few mitotic regulators that have been associated with tumour progression. Finally, this mouse model with altered mitotic regulation will be a valuable tool to improve current therapeutic strategies in cancer, mostly directed against mitotic progression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Robustness, evolutionary optimality and plasticity of microbial signaling'.

assistant: **Concept**

Most signaling and regulatory functions in the cell are executed by protein networks rather than by individual proteins, and it is therefore essential for biology to understand how the design and function of these networks have been shaped by the evolution. Despite differences in biological functions and molecular composition, all protein networks underlie similar evolutionary constrains on their performance and design, such as necessity to be robust against extra- and intracellular perturbations or to extract information from noisy environment. Moreover, although it can be assumed that a particular network has evolved to optimally solve certain problem, detailed quantitative analyses of optimality of the network performance are largely missing. Similarly little explored is the question of the network plasticity: how networks adapt to changing environmental conditions by adjustments of their structure and function, either regulating protein levels or undergoing microevolutionary changes. The goal of this proposal is to elucidate general features responsible for robustness and plasticity of cellular networks, using signaling networks in bacteria and yeast as well-tractable and relatively simple model systems. To achieve that, we will combine quantitative real-time analyses of the network function, primarily using high-throughput fluorescence microscopy, with computational modeling and with experimental microevolution, while exposing the networks to such common intra- and extracellular perturbations as variations in protein levels and in temperature. We expect our comparative analysis to provide general insights into the mechanisms of robustness and evolutionary optimization of cellular networks, thereby substantially advancing our understanding of biological systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Cell penetrating peptides: Modelling trans-membrane insertion' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The lipid bi-layers of biological membranes are not permeable for hydrophilic molecules under physiological conditions. However, numerous biomedical applications, such as drug delivery and gene therapy, rely on reliable way of the transmembrane translocation of proteins, fragments of DNA and other water-soluble compounds. Thus, the search for possible transduction agents continued for several decades. Cell-penetrating peptides (CPPs) are recognized to be amino acid sequences, which make an effective transduction of the hydrophilic molecules through the cell membrane possible. The transduction is claimed to be spontaneous and energy-independent process. This makes CPPs very attractive for numerous applications. Some of the CPPs are structural parts of natural proteins, while others are purely artificial or engineered sequences. Different molecular cargoes can cross the membrane being covalently bound to CPPs, which is already used in biomedical researches.Although the CPPs are widely studied for more then a decade, their transduction mechanism is still not understood. Several possible models are proposed, however, there are no experimental techniques, which can reveal the molecular details of the translocation process and distinguish between these models. The macroscopic transduction rates of particular CPPs are of great interest for practical applications, but cannot be easily determined experimentally. Molecular dynamics simulations provide unique opportunity to study the transduction of CPPs in atomic details and to measure the transduction rates in any desirable conditions.In the present project extensive molecular dynamics simulations of various lipid bi-layers in the presence of the cell penetrating peptides will be conducted in order to observe the event s of tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'European experience exchange' (EUREX), addressing dissemination and exploitation.

assistant: **Impact**

The overall objective of this Action is to assess, classify, categorise, and exploit the experience of ESSI Process Improvement Experiments (PIEs) and to make this experience accessible to everyone (including subsequent PIE Users) in a convenient form. In particular, we want to collect and make available to a broad European audience information about Software Best Practice and its introduction in specific problem domains. In addition, we will use this opportunity to inform a wider community of software practitioners, including potential new PIE applicants, about the collective experience of previous PIEs in their Problem Domain to avoid duplicated effort.ACTIONSThe essence of the subject and material to be disseminated consists of PIE experiences documented and commented with expert opinions. This material will be gathered at Regional Workshops and at a pan-European Workshop and a Conference.The problem domains to be addressed will be defined in the beginning of the project. It is one of the important activities of this Action to classify and filter the PIE problem domains in order to determine areas of particular value to European Industry. Examples of candidate problem domains include configuration management, test and verification, object-oriented methods, formal methods, metrics, complexity and estimation. The Regional Workshops will be theme-based and target the problem domains selected.The material from the pan-European Conference will form the basis of a new Series of Books from Springer-Verlag, the Software Best Practice Reports, and of Executive Reports (of the content of the books, summarising benefits and risks of real cases). There are three major dissemination mechanisms foreseen within the EUREX project: 18 Regional Workshops, a pan-European Workshop and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Nanoencapsulation for Energy Storage and Controlled Release'.

assistant: **Innovation**

The main vision of the project ENERCAPSULE is the development of nanoencapsulation technologies based on switchable nanoscale barriers for novel generation of controlled energy storage and delivery systems. These systems will be based on the “smart” nanocontainers (size below 200 nm) loaded with the energy-enriched active components: materials for thermal energy (both latent and based on chemical reactions) storage and substances for bioenergy (ATP or its components) storage for synthetic biology platforms. First novelty of the proposed project is the protection of the nanoscaled energy-enriched materials against environment during storage and controlled release of the encapsulated energy on demand only using both inherent properties of nanocontainer shell or biomimetic nanovalves introduced as shell components. Another main objective of the project is to study the structure and surface-to-volume properties of the energy enriched materials dispersed and encapsulated on nanoscale. The questions of stability of energy nanomaterials, influence of the nanocontainer shell on their energy capacity, homogeneity and operation lifetime will be investigated. Polymer organic nanocapsules with hollow interior and mesoporous carbon nanoparticles are chosen in the project as main types of the nanocontainer scaffolds for energy-enriched materials due to their high loading capacity and potential to design their shells to attain them controlled permeability properties. At the end of the project, developed novel energy storage and delivery systems will be combined within one network having several mechanisms for release and uptake of energy, which can be activated depending on type and intensity of the external impact (demand). The potential applications of such multienergy storage syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Role of OligoSaccharyl Transferase enzymes in developmental signaling and congenital disorders of glycosylation' (OSTers), addressing dissemination and exploitation.

assistant: **Impact**

Congenital disorders of glycosylation (CDGs) are genetic defects affecting the assembly and addition of asparagine (N)-glycans to proteins. N-glycosylation occurs in the endoplasmic reticulum by the Oligosaccharyl transferase (OST) complex. Mutations in components of OST complex are identified in CDG patients with broad clinical features. However, the mechanisms by which OST mutations cause phenotypic heterogeneity are not known. Moreover, in vivo studies on the precise role of individual OST components in animal development are lacking. In this framework, the goal of this proposal is to understand the function of OST complex during animal development, with a focus on their role in the regulation of developmental signaling pathways. The final aim will be to provide insights for deciphering some aspects of patients’ clinical features with OST mutations. This might lead to new frameworks for targeted therapeutic manipulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Adaptive Management of Barriers in European Rivers'.

assistant: **Innovation**

Rivers rank among some of the most threatened ecosystems in the world, and are the focus of costly restoration programmes that cost billions to taxpayers. Much of Europe depends on water from rivers for drinking, food production, and the generation of hydropower, which is essential for meeting the EU renewable energy target. Yet only half the EU surface waters have met the WFD’s 2015 target of good ecological status, due in part to the fragmentation of habitats caused by tens of thousands of dams and weirs which also pose a flood hazard. Some barriers are old and out of use, but may have historical value, while the life span of others will soon come to an end and may need to be removed. But barriers also provide energy, water, fishing and leisure opportunities, and may also help to prevent the spread of aquatic invasive species. Improving stream connectivity has been flagged as one of the priorities for more efficient stream restoration but effective rehabilitation of ecosystem functioning in European rivers needs to take the complexity and trade-offs imposed by barriers into account. AMBER will deliver innovative solutions to river fragmentation in Europe by developing more efficient methods of restoring stream connectivity through adaptive barrier management. The project seeks to address the complex challenge of river fragmentation through a comprehensive barrier adaptive management process, based on the integration of programme design, management, and monitoring to systematically test assumptions about barrier mitigation, adapt and learn.


**Keywords:** Water Framework Directive, Habitats Directive, Floods Directive, Hydropower, River fragmentation, connectivity, barriers, Adaptive Management, Stream Ecology, Mitigation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Innovative Processes & Methodologies for Next Generation Sustainable Functional Electronic Components and Systems' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Europe currently has a leading position in key digital technologies. However, functional electronics is one of several emerging digital transformation areas with no established players, but with the potential to significantly disrupt strategic sectors. Harnessing the full potential of functional electronics will enable Europe to exploit cutting-edge climate-neutral digital solutions to strengthen its leadership, and to seize on emerging opportunities by addressing existing technological gaps in multiple sectors. Functional Electronics has found application in a wide range of sectors and domains including in hybrid Integrated circuits (ICs) or flexible systems. Its global market was worth €15.4billion in 2017 and is expected to reach €37.7billion by 2023, a CAGR of 11%. Despite this growth, functional electronics can generate additional value via the adoption and implementation of new and efficient eco-design approaches at product, process, and business model levels. SusFE will advance the development of functional electronics for green and circular economy by developing a sustainable design and production platform for roll-to-roll manufacturing of the next generation of wearable and diagnostic devices that combine a SusFE toolbox of sustainable components comprising novel flexible integrated circuit (FlexIC) on polymer substrate with ultra-low power printed sensors/biosensors, and wireless communication driven by an organic and recyclable bioenzymatic fuel cell. This will lead to highly integrated and autonomously operating systems that are lightweight, environmentally sustainable, and low-cost. SusFE uses of a combination of sustainable materials and processes to deliver climate-neutral digital solutions including wound monitoring, self-blood sampling/testing and point