RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Transport infrastructure technologies and management' (TITAM).

assistant: **Concept**

On the 1st May 2004 the Czech Republic became one of the 25 member countries in the enlarged European Union. Its unique location at the centre of Europe between Austria, Germany, Poland and Slovakia makes it an important transport crossroad (both figuratively and literally speaking) between the old and new EU Member States. This has greatly increased the demand on the transport infrastructure (e.g. the volume of heavy trucks increased by 40% within the first weeks of joining the EU).In response to these new demands; the Czech Republic is seeking solutions to reduce the damaging effects of the increased loads on the transport infrastructure. The main focus is on the development and application of new technologies for managing the transport infrastructure. This is being undertaken by the Transport Research Centre (CDV) which used to be a part of the former Czechoslovak Federal Transport Research Institute and has been undertaking research in the transport field for more than fifty years.Currently CDV is the only research institute under the responsibility of the Ministry of Transport that specialises in transport issues. CDV experts play a considerable role in the design, construction, and maintenance of highways and highway structures, including developing relevant technical standards. Currently the focus is on design, construction, maintenance and repair of roads and bridges. Building a new area of competence concerning the innovative methods of transport infrastructure technologies and management (TITaM) at CDV is to be supported through the TITaM project.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Precise Predictions for Higgs and New Physics Signals with Jets at the Large Hadron Collider' (PRECISIONJETS4LHC).

assistant: **Concept**

Many of the Higgs and new physics searches at the Large Hadron Collider involve signals with jets of energetic hadrons. This proposal will improve the theoretical predictions for such processes, focusing on three different aspects:1) Since backgrounds depend on the number of jets, search analyses are often separated into bins with a particular number of jets to improve sensitivity. I propose to improve the precision of these exclusive jet cross sections, through a next-to-next-to-leading logarithmic order calculation using the N-jettiness event shape. Improved predictions for the benchmark W+N jet process and the Higgs+N jet signal will be obtained in a form that is suitable for reweighting Monte Carlos. The latter is important for constraining the couplings of the observed new particle at the LHC, which will help establish whether it is the Higgs boson.2) Given the excellent performance of the ATLAS and CMS detectors at the LHC, there is an expanding interest in techniques that exploit the substructure of jets. I aim to obtain an analytic understanding of the behavior of jet substructure observables and test Monte Carlo simulations, which do not include higher order effects and are the most common tool for substructure analyses. Substructure observables that will be considered include: jet mass, jet charge, 3-subjettiness (relevant for boosted top quarks) and mass-drop/filtering. I propose to investigate the factorization and resummation of these techniques, as well as their calculation beyond the leading logarithmic accuracy of the Monte Carlo parton shower.3) I also proposes to calculate the collinear radiation in a jet at next-to-next-to-leading order, fully differential in the three body phase-space. This will be used to test at this order the exponentiation of log
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamics of p53 mutant reactivation and the anti-carcinogenic action of engineered resveratrol analogues' (2021-2027).

assistant: **Innovation**

The project proposal aims to engineer a bacterial host to produce variants of secondary metabolite resveratrol and address the interrelationship between dynamics, structure and function of a system of high medical interest, the tumor suppressor protein p53. The study considers to elucidate the mode of action of these molecules against the p53 mutants and work on new concepts for cancer therapy. Inside the cell, the folding of a protein is a fast and robust process. Sometimes, however, sudden changes in the balance between different existing forces result in incorrect folding of the peptide chain, which ends up generating amyloid aggregates within the cell that lead to the gain of toxic function, since these aggregates can conduct to death of the cell in question. Most amyloidogenic pathologies are neurodegenerative, however the aggregation also plays an important role in cancer. The project provides a broad framework for the study of the resveratrol derivatives acting as p53 aggregation inhibitors by using cutting-edge tools of computational resources, metabolic engineering and structural biology. But could, in principal, be applied to exploit the chemical diversity of other biocompounds similarly intending to act as less cytotoxic agents in a more effective antineoplastic therapy, which represents one of the major existing scientific gaps. It is a proposal on a very important topic that will be studied from a unique perspective.


**Keywords:** Molecular interactions,   Bioinformatics,  p53 reactivation, Resveratrol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Role of glucocorticoids in the development of diabetes type 2' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

The postdoctoral training of the applicant in the Lab. of Prof. S. Okret at the Karolinska Institute is justified for their notable career in the field of steroid action and factors that regulate cellular glucocorticoid sensitivity, both in health and disease. This training will provide Javier Campion the knowledge necessary in important techniques of molecular biology as transgene constructions, transfections, transgenic mice, immunocyto chemistry, and GST pull down assays. Moreover, we expect to publish the results in valuables papers. This fact, joined to the personal experience living and working in a foreign country, will contribute to the applicant to enrich him both in a scientific and personal fashion. The host institution will obtain during the time of the project a professional with the knowledge necessary about the insulin signalling, steroid action, and different techniques in molecular biology that is capable of carry out the project with success.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'AI-driven cardiac ultrasound analysis', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Heart ultrasound is the most versatile, most widely used, and cost-effective heart imaging method. Accessibility to ultrasound imaging is growing rapidly as the devices are getting cheaper and smaller. However, interpretation of the acquired images creates a bottleneck; it requires        substantial skill, it is long, manual, and prone to errors and variability. Ligence is remodelling the quality, difficulty, and length of echocardiography with an AI-driven tool to automate the whole analysis of heart ultrasound images. Deep learning neural networks classify heart image        views, detect heart cycle phases, and perform measurements. It seamlessly integrates with existing infrastructure in hospitals, meaning that moments after images are loaded onto the hospital's network the results are accessible on any workstation. This results in dramatically increased        accessibility and analysis quality, earlier diagnosis, and better patient risk stratification, monitoring, and patient management.


**Keywords:** Cardiac and Cardiovascular systems,AI-driven tool,Risk stratification,Increased accessibility,Echocardiography ,Early diagnosis,Automation,Deep neural networks
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'MEthodology for Describing the Accessibility of Transport in Europe' in the context of a Seventh Framework call.

assistant: **Objectives**

The European FP7 on Transport is highlighting the importance of developing pan-European transport systems for the benefit of all citizens, with reference to the European transport policy. Despite recent progress made, many European citizens are still experiencing barriers and reduced accessibility to transportation. The overall objective of MEDIATE is to contribute to the development of inclusive urban transport systems with better access for all citizens.  The MEDIATE project is a Coordination and Support Action and the project objective is to establish a common European methodology for assessing, describing and measuring accessibility to transport. The MEDIATE project will assist public authorities and transport operators in achieving equality of access by: identifying indicators for describing accessibility, providing a self-assessment methodology for measuring accessibility, making comparisons with good practice solutions, exchanging knowledge among stakeholders involved and disseminating expected results.  The MEDIATE project consists of eight partners and will actively involve a network of public transport operators and local authorities, an End User Platform (including people with disabilities, older people, and people facing barriers to transport), industry, and experts within the field of accessibility, at each stage of the process. This will ensure that all stakeholders are involved in providing input and facilitating dissemination in an European context.   MEDIATE is expected to have an impact on the following: development of more inclusive urban transport systems with better access for all,  establishment of common European standards,  and European cooperation.  A common European methodology for assessing, describing and measuring accessibility of transport
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Genetic Control of Gene Expression in Cancer Risk'.

assistant: **Objectives**

Breast cancer is one of the most common cancers affecting women, with more than 330,000 new cases diagnosed in the European Union in 2008. It is crucial to understand the genetic causes behind this fatal disease to better stratify women at higher risk and to reduce breast cancer incidence. Inherited susceptibility to breast cancer is largely due to polygenic variation, and only about 30-35% of familial cases are explained by known risk loci. The central aims of this proposal are to identify new genetic risk loci, by redesigning breast cancer susceptibility studies, and to unravel the role of cis-regulatory variation in disease risk and tumour biology.Recent data suggests that most unidentified risk loci are cis-regulatory, affecting the expression of both close and distant target genes. We propose a novel approach to identify susceptibility loci that focuses on variants with known regulatory potential. Differential allelic expression (DAE) is a robust technique to identify cis-regulatory loci, and we will perform the first case-control study using DAE as a quantitative trait.We also aim at understanding the interaction between cis-regulation and mutations, both germline and somatic. We have evidence that common BRCA2 and TP53 haplotypes correlate with different levels of gene expression, and we are interested in understanding how these modulate penetrance of BRCA2 germline mutations in carriers and the clinical characteristics of tumours harbouring somatic TP53 mutations.Our studies will impact on breast cancer incidence and understanding of tumour biology. The identification of novel breast cancer risk loci will improve individual risk assessment, stratification of patients at higher risk, pre-disease management and public health as whole. Dissection of biological mech
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Chaperoning molecular cascades: Hsp90 assisted folding of cell cycle regualting kinases', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The smooth action of signal transduction cascades is essential prerequisite for higher organisms, and failure here is the major cause of cancer. Crucial for these cascades is assistance by the molecular chaperone Hsp90. It supports protein folding for a su bset of proteins, most of which are oncogenes, and is a cancer drug target itself. Just over 100 substrates are identified to date, more than 50 are kinases, but the specific folding problem of kinases is elusive. We will focus on Cdk kinases, which contro l the cell cycle. They are a homologous family, some of its members require Hsp90, others do not. We set out to establish a new innovative concept to this fundamental question of explaining Hsp90 specificity by selective modulation of kinase stability. We use a multidisciplinary approach combining biopysics, biochemistry and cell biology, applying advanced protein engineering techniques and cutting edge NMR spectroscopy.First, we will analyse the stability of Hsp90-dependent and independent Cdk kinases for full length proteins, kinase domains and fragments thereof, and we will test whether their activation or inactivation influences stability. Second, we will determine under which conditions Cdks bind to Hsp90. We will analyse whether activation processes an d stability influence Hsp90 binding. Third, we want to determine the conformation of Cdk kinase in the Hsp90-bound state. We will map the binding site of Hsp90 in Cdks, and we will follow the kinase's structure throughout the Hsp90 chaperone cycle. Fourth, we will map the binding site of the kinase substrate within Hsp90 and monitor its conformational changes. Finally, we will go into the living cell to identify the structural elements that affect stability of Cdk kinases in vivo. We expect to provide a new para
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Delineating the Novel Mechanism of VPg Dependent Virus Translation Initiation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Norovirus, a member of the Caliciviridae family of small RNA viruses, is the major cause of viral gastroenteritis worldwide, often referred to as ‘winter vomiting disease’. Over a million people were infected with the virus last winter in the UK alone. Frequent outbreaks in hospitals and schools put increased pressure on healthcare services. Once thought of as a self limiting infection, norovirus has more recently been linked with higher mortality rates in older people as well as chronic infection and increased morbidity in immunocompromised patients such as those receiving chemotherapy. Despite being increasingly studied no treatments for control of norovirus infection are available. Noroviruses use a novel yet poorly understood mechanism for viral protein synthesis. This mechanism relies on the interaction of cellular factors with a virus-encoded protein called VPg, which is covalently linked to the viral RNA. Astroviruses, which also cause gastroenteritis, are thought to use a similar mechanism. Because this mode of translation is distinct from normal cellular protein synthesis it will provide targets for the development of new anti-viral therapies. This proposal plans to use a mammalian in vitro translation reconstitution system to delineate the mechanism of VPg-dependent translation initiation used by noroviruses and astroviruses. Highly purified mammalian translation factors and ribosomal subunits will be combined with viral RNA to recapitulate VPg-dependent translation initiation, identifying which factors are essential for this process. Once identified, specific interactions between VPg and cellular factors will be characterised in detail. The potential of developing anti-viral strategies, targeting these interactions, will then be examined. This proposal will r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Does excessive junk food consumption change the way the brain reward system processes intrinsic rewards?' (REBOST) under Horizon 2020.

assistant: **Objectives**

The prevalence of obesity worldwide continues to increase dramatically: 39% of adults are now overweight or obese. Excessive consumption of highly palatable sugar and fat laden foods, often referred to as “junk foods”, plays a central role in the development of obesity, possibly by dysregulating the brain reward system. The REBOST project aims to investigate the neurological mechanisms by which excessive junk food consumption adversely affects the reward system. I hypothesise that excessive junk food consumption desensitises the reward system, which alters responses to different intrinsic rewards. This project is innovative in that it investigates the neuronal and behavioural alterations in sensitivity to rewards beyond conditioned food rewards, by also studying the responses towards a secondary intrinsic (sexual) reward. This will be achieved by using a unique behavioural design and advanced in vivo techniques (fibre photometry, dLight1 and chemogenetics). This protocol allows to simultaneously investigate real-time neuronal activation and behavioural effects during all distinct phases of reward: i) expectation, ii) approach and iii) consummatory behaviour. Another highlight of the project is the use of the Cafeteria Diet model (CAF). CAF mimics human behaviour more accurately than other models, by feeding rats a choice of the same unhealthy, but palatable products as humans. By integrating complementary expertise on CAF and food reward from the ER and on sexual behaviour and the advanced techniques from the host, the project will unravel the effects of CAF on the specific brain reward projections from the Prefrontal Cortex to the Ventral Tegmental Area. This will contribute to explain the underlying mechanisms of the development of obesity and the vulnerability of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A night Among stars and lapillus' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

2009 will be the world year of Astronomy with a special dedication to Galileo to celebrate the astronomic discoveries of Galileo Galilei. We decided to anticipate this event in our researchers’ night focusing it on the astronomy field. For this reason the main partners will be INAF (National Institute for Astrophysics) Capodimonte Observatory, without excluding our traditional partners Vesuvian Observatory, INOA and San Pietro a Majella Conservatory. The activities will set in Piazza Dante and in the beautiful cloister and auditorium of Conservatory, to guarantee the necessary in-door and out- door spaces. Piazza Dante will host the researchers stands, aimed to show the researchers’ activities, interactive experiments, videos, instruments and to talk and make acquaintance with researchers; a portable planetarium, the running music of Contrabbanda and the children dedicated shows of “Le Nuvole” (see their web site at www.lenuvole.com ): their stars related street-art performances with jugglers playing as researchers and a piece on Galileo’s life. A digital photographic challenge: “shot the researchers’ night”, open to researchers and public, will also take place between 18,00 and 21,00 and the winner of both categories will be awarded with a diploma and a dinner for four people. As contraposition to the planetarium a special area will host a simulation of heartquakes. A chorus of researchers leaded by maestro Lo Gatto and his wife Donatella (researcher in chemistry) will re-interpret ancient villanelle of Galileo’s time with modern rhythms of jazz, rock pop music. The cloister of Conservatorio will host the photographic exhibition “portrait of a researcher” with an extra section for Italian Flickr bloggers (Flickr is the most famous photo-blog, to have an idea see www.fl