RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Participatory approaches in science and technology'.

assistant: **Objectives**

It has been widely recognised within academic and policy circles that deliberation of science-based issues and formulation of policy is no longer the exclusive realm of politicians and experts. In order to develop robust, transparent and effective policie s new participatory structures for involving a wide range of actors and the public are urgently required. The PATH project will form a network bringing together academics, practitioners,policy-makers and stakeholders to exchange knowledge and develop fut ure directions for the involvement of society in the deliberation of science-based policy issues. The project will focus specifically on two persistent challenges: scale and representation. To date, participatory processes have largely been used at a lo cal scale. However, many policy challenges are relevant to a regional or international scale and hence guidance on how participatory processes can be scaled-up is a pertinent issue. Of key concern in such processes is how best to represent a diverse and diffuse public as well as 'silent voices' (e.g. children, future generations). These two cross-cutting themes of representation and scale will be explored at a generic level, and via three case study areas, namely: genetically modified organisms (GMOs) i n agriculture, biodiversity conservation and nanotechnology. Information exchange and development of innovative future directions will be achieved through an international workshop focusing on issues of representation and scale, and an international conf erence which aims to integrate elements of best practice in science-based policy deliberation and sketch out future directions with regard to the three case study areas. Project outcomes will be disseminated to academic and non-academic audiences throug h policy briefs,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissipative Self-Replication', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

This research project aims to address one of the Grand Challenges in contemporary science: the de-novo synthesis of life. More specifically we aim to achieve, for the first time, Darwinian evolution in a system of fully synthetic molecules. This ambitious aim may be reached by combining the expertise of the experienced researcher on out-of-equilibrium systems with the expertise of the host lab on self-replicating molecules. This combination will enable replication to be operated out of equilibrium. The central idea is to run the self-replicating molecules in a regime where replication and replicator “death” are competing processes. Replicators only survive as long as they replicate faster than they are destroyed. The simplest implementation of such regime is a flow system in which replicator building blocks are continuously flown in, while outflow of part of the replicator solution constitutes replicator “death” through a process of (non-selective) physical removal. In addition to replication, two more ingredients are required for Darwinian evolution: mutation and selection of the mutants that are best adapted to their environment. To realise those elements, we will create a mixture of replicator mutants by offering a mixture of different building blocks. Alteration of fitness parameters (by altering the environment) should shift the mutant distribution towards the replicators that are best adapted to the new environment. Environmental parameters that will be explored include flow systems with thermal gradients (selectively trapping replicators that assemble into long fibers) and co-solvents and salts (affecting the supramolecular interactions that hold the replicator assemblies together).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Researchers Night 2007 in the Czech Republic' (RN07CZECHREP).

assistant: **Innovation**

The purpose of this project is to plan, prepare and implement Researcher’s Night in three major cities and twenty three other locations throughout the Czech Republic. This project aims to: present researchers as “normal” people to the general public, show research professions as interesting and fun thus making them appealing to young people, promote science in elementary and secondary schools, and demonstrate how Europe supports its researchers and the sciences. Eliminating gaps and building bridges between researchers and the general public is also a focus of this project.  The Project is based on a partnership made up of five organisations. The participants have a wealth of experience with 5th and 6th Framework Programmes and with activities promoting researchers and science. Some of the partners also took part in Researcher’s Night 2006 in the Czech Republic.  When planning the programme and the individual activities, emphasis was placed on interactivity and entertainment. Hands-on practical experiments, scientific demonstrations, guided tours through different research workplaces, competitions, and games are the main types of attractions prepared for the public. Researchers will be also presented in unexpected professions such as musicians, photographers, or writers and this will help to change the public perception of researchers as “mad” people closed up in their secretive, distant labs. The compulsory drawing competition and the EU stand will also be implemented in the three major locations. European support of research and development will be also demonstrated and researchers who have benefited from the support will give testimony in person.   All in all, Researcher’s Night 2007 is a great opportunity for the public and the researchers to meet face to face and f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Shortening the path to rare disease diagnosis by using newborn genetic screening and digital technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

In the EU alone, according to the Orphanet DB (https://pubmed.ncbi.nlm.nih.gov/31527858/), 30 million persons, 3,5-6% of the general population, are affected by one of the 6,172 different rare diseases (RDs) of which 72% are genetic and 70% affect children. The path to diagnosis for people suffering from a RD is burdensome, often severely delayed by a diagnostic odyssey. Lack of timely diagnosis affects disease management, family planning, identification of potential beneficial treatments and / or clinical trials. This unacceptable situation does not meet the concept of equity for EU citizens, and requires rapid, structured, and cost-effective corrective actions. The Screen4Care (S4C) consortium will leverage the genomic and digital advent to develop and pilot genetic NBS and AI-guided symptom recognition algorithms, while accounting for all relevant legal, regulatory and ethical considerations. S4C aims to harmonize the results of existing efforts in a horizon scan, by looking at the totality of the available data resources, diagnostic algorithms, and other initiatives with similar ultimate goals.The genetic NBS will interrogate 1) currently treatable RDs (TREAT-map gene panel), 2) actionable RDs (ACT-map gene panel) in 18.000 new-borns in 3 EU countries (D, It, and Cz). Further, S4C will offer whole genome sequencing (WGS) to early symptomatic babies, tested negatively during panel-based NBS to identify known NBS-escaped RDs and novel genes/phenotypes. S4C will also provide two digital diagnosis support systems for RD on the basis of features and symptom complexes: 1) federated ML- and literature-evidence-based algorithm for continuous and automated screening of EHR and 2) meta symptom checker with virtual clinics for patients and HCP offering the possibility of incre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Research on extraction and formulation intensification processes for natural actives of wine' (WINESENSE) under Seventh Framework.

assistant: **Objectives**

The Wine industry is an important sector for the EU economy and the development of new wine-related products could lead to sustainable growth and development of the sector.WineSense proposes to improve the extraction process to catch most of the active parts of the polyphenols (present in grapes), to define a suitable formulation for pharmaceutical applications, food, and cosmetics additives based on Solvent Free Microwave Extraction,Microwave Assisted Extraction (MAE), and emulsion-Template techniques combining high pressure and antisolvent effects.WineSense combines the efforts of industry and academia in order to optimize the polyphenol extraction and formulation techniques, intensifying the process and reducing the loss in antioxidant capacity. Only thus we can synthesize an actual active compound that is suitable for health, food and wellness applications, in response to the models and innovative approaches of natural products and the challenges of the European Knowledge-Based-Bioeconomy. This project sets the framework for the transfer of knowledge and long-term collaboration between 3 industrial and 1 academic partners in the field of extraction and formulation of most of the active part of polyphenols (soluble and non-soluble).ToK and collaboration will be fostered through mutual exchange of researchers: 11 researchers from academia and industry will be involved in 88 months of secondments; 2 of them will be experienced researchers recruited to complement the consortium capabilities (36 months of recruitment).Additionally, this project aims at creating strong impact in the involved partners by fostering long lasting networks around its driving technologies such us bio & nanotechnology (EU KETs) and also exploring its potencial applications helping mantein Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'The Role of Gender in Virtual Work Environments'.

assistant: **Concept**

Virtual forms of interaction at work are gradually replacing the traditional in-person work style across many knowledge-intensive industries, and this change could signal the beginning of a lasting shift in how work is conducted. Despite obvious benefits, this emerging trend also raises an array of complex challenges, namely related to inclusiveness and participation in virtual work environment. Understanding the complexities of inclusive interactions in these digital environments, and what new challenges may arise, is a crucial issue. As a first step, this proposed research program seeks to focus on female participation and engagement on virtual work settings. In doing so, it aims to investigate: how interactions from and towards women are different compared to their male peers in virtual work environments; What are the drivers of (potential) differences? And finally, how digital platform architecture and design opportunities could be exploited to alleviate the barriers to female participation and interaction in these emerging work settings? To address these questions, a large-scale randomized vignette (survey) experiment with actual professional respondents is proposed. The results of the proposed experiment can enhance our understanding from the new virtual form of work and could generate implications for companies on how to arrange and design their virtual work environments.


**Keywords:** virtual work environment, gender, platform member engagement, vignette experiment
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Applications of ionomer hlasses' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This application will study acid degradable fluoro alumino phospho silicate glasses and their phase separation and crystallisation behaviour with the objective of developing novel glass and glass ceramic materials for the following applications (i) A glass ceramic inlay for dental use based on apatite that can be used as inlays as an economic alternative to the existing mercury based amalgam fillings. The material will be capable of being cast using the existing lost wax techniques and equipment currently available in dental laboratories. (ii) A high strength castable bone substitute based on an interlocking microstructure of apatite. (iii) A bioactive glaze for conferring bioactivity and osseointegration on medical grade alloys. (iv) A microporous glass for performing rapid cost effective industrial separations of biological macromolecules by size exclusion and affinity techniques that is capable of being regenerated by washing with alkalis. (v) A photomachineable glass ceramic that exhibits better machining resolution than the current materials and can be machined using less toxic and corrosive acids than hydrofluoric.  Biomaterials research and development is a rapidly expanding area in which Europe can expect to excel. The current World market for medical materials and devices is estimated at over 20 billion ECUs and has a growth rate of between 7 and 12 % per annum. The United States have invested heavily in this sector and, as a result, meet a significant proportion of the needs of the European market. However, a substantial body of expertise exists within Europe, and the Union is therefore well positioned to benefit from this expanding market. To address specific requirements, the partnership brings together several leading industrial and academic groups in the c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for '3D Multi-Process Sequential Integration for Smart Sensor Interfaces' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The IoT is composed of connected devices that are characterized by their interaction with the environment via a plethora of sensors and actuators. The trend goes to ever more complex interactions and thus an increase in the number of different sensors integrated in the same product, which in turn requires the processing capability to handle all of those sensors. At the same time those systems are expected to still perform on an ever lower power budget, preferably so low as to be able to operate purely on power scavenging. And of course the cost needs to be moderate too. The electronics at the heart of such a system needs to be mixed-signal electronics that interfaces to the analog sensors and actuators, but can also provide the necessary digital processing power.  3D-MUSE wants to spearhead   the progression from what we shall refer to as 'systems-in-stack' to true 'systems-in-cube' that monolithic/sequential 3D integration will enable. We define the former as a 3D system that is characterized by locating functional blocks within a single plain in the (typically parallel/wafer-bonding) 3D integration stack, while the latter makes use of the full emancipation of the interconnect density in the third dimension of sequential 3D integration and rather implements functional blocks in a volume comprising multiple tiers. We shall demonstrate this concept by conceiving novel architectures for micro circuits in a volume in a two tier 3D sequential integration process. In particular, we have identified mixed-signal circuits as, on one hand, a major bottleneck for functional performance scaling of sensor nodes and smart sensors in the IoT and cyberphysical systems, and on the other hand, excellent candidates for beneficial trade-offs when implemented as circuits in a volume with u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Mapping the Intraflagellar Transport - A High-resolution Study of Intraflagellar Transport Trains in Chlamydomonas Cells' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Cilia are highly conserved eukaryotic organelles that, with the exception of fungi and higher plants are present in nearly all types of organisms from protists to mammals. Through their motility, sensory, and signaling functions cilia play crucial roles in human physiology and development. Defects in cilia have profound impact on human health. Cilia assembly requires a dedicated protein shuttle, intraflagellar transport (IFT), a bidirectional motility of multi-megadalton protein arrays along ciliary microtubules. Although the overall mechanism of transport is generally described, complete high resolution structural description is necessary for the detailed understanding of this complex system.I propose the in-depth structural analysis of IFT features, train types, cargoes, interactions with the molecular motors in the cilia model organism Chlamydomonas. This approach will bring us both a molecular resolution of incorporated protein complexes and dynamic overview of their relations.The project objectives will be achieved by an elabrated chain of methods based on correlative microscopy, combining the specificity of nanobody labelling with the structure preservation and molecular resolution of cryo-electron tomography. We plan to develop two independent workflows for tracing the IFT features based on the most progressive cryo methods in the cooperation with the project partners.It is anticipated that an detailed ultrastructural 3D analysis of intraflagellar transport will provide new fundamental mechanistic insights into this very important biological process. We also expect an overlap to the whole structural biology field due to the methodical development, which will be universally applicable for another structural studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A molecular and cellular mapping of the fenestrated vasculture of the circumventricular organs: from physiology to pathology.' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

In the brain, the blood vasculature harbours a unique specification: the Blood Brain Barrier (BBB), which restricts blood/brain exchanges to a select set of molecules. This particularity makes neurons blind to most peripheral signal. However, the peripheral organs and the brain have to communicate to maintain homeostasis and body functions such as metabolism, reproduction or growth. This dialog occurs in specific brain regions, the circumventricular organs (CVOs), characterized by a fenestrated vasculature allowing the free diffusion of blood-borne factors and secretion of neurohormones in the blood stream. Thus, CVOs are crucial for the periphery/brain dialog. Despite the apparent pivotal role of the fenestrated vasculature of the different CVOs in the blood/brain exchanges, little is known about their organisation, cellular composition and transcriptomic profile. Unlike the BBB vasculature, the fenestrated vasculature of the CVO is poorly described and the role of mural cells, known to support BBB vessel development and maintenance, in CVO remains undetermined. Equally unknown is how pathological contexts such as Alzheimer’s Disease (AD), showed to alter BBB vessels integrity and function, impact the CVO vasculature. In the VesselCVO project, we set out to fill in the void of information about the molecular and cellular anatomy of the CVO vasculature, the similarities and differences amongst CVOs and other fenestrated vasculature of the central nervous system, the relative role of mural cells present in these regions and translate this knowledge in the pathological context of Alzheimer’s Disease. These ambitious objectives will be achieved through the use of a multidisciplinary and complementary set of transcriptomic, bioinformatic, neuroanatomic and vascular biology