RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Hierarchical gradient metals by additive manufacturing' (HIGMAM) targeting Horizon Europe.

assistant: **Abstract**

Over the last decade, the steadily increasing research on gradient-structured metals and alloys has demonstrated great successes of this biological and nature-inspired concept to evade the strength-ductility trade-off dictating in regu-lar engineering materials. However, given the intrinsic limitations of conventional manufacturing methods, the currently engineered structural gradient materials are all featuring a linear pattern, usually from exterior to interior, with only simple structures of grain sizes, twin spaces, lamellae spaces, or combinations. A recent preliminary study of my research team accidentally discovered that additive manufacturing could produce periodic and 3D gradient microstructures with not only simple microstructure features, but also hierarchical ones, from grain size to sub-grain boundaries and even lattice distortions. The hierarchical gradient microstructure keeps the same level of high strength but doubles the failure strain compared to the conventional microstructures. This inspires us to systematically investigate the possibilities and boundaries of these new hierarchical gradient microstructures by additive manufacturing. Due to its extreme complexity across multiple scales and physics laws in correlating process, microstructure, and property of such new materials, we aim to develop a systematic approach for designing hierarchical gradient microstructures by using design of experiments, in-depth and multiscale characterization methods, multiphysics and multiscale numerical models, and data informatics. The intelligent integration of the physics-based and data-driven models will eventually boost the dimensionality, efficiency, and accuracy of the modeling approach for the design of the complicated hierarchical gradient microstructure in 3D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Field emission backlight' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The project is expected to deliver an experimental 50mm x 50mm x 10mm field emission backlight incorporating a Ta-C emitter, with a high brightness of 20,000 cd/m2. The research work will concentrate on optimising the DLC deposition method, substrate material, nitrogen doping, and on the development of a resistance ballast layer beneath the DLC, to maximise the spatial uniformity and temporal stability while minimising the impact on efficiency. This experimental work will be complemented by theoretical device modelling to improve our understanding of the emission process, and in particular the low effective energy barrier level of typically 0.03 eV derived from Fowler-Nordheim plots. The research is expected to deliver an optimised DLC / resistive layer design, an appropriate deposition process and an improved theoretical understanding of emission mechanisms from Ta-C.A system approach is adopted for the field emission device development, and therefore the proposed work includes phosphor, spacer and getter development, cell fabrication, electronic drive circuitry design, build and test, and optical characterisation and lifetesting of the device.DLC has been characterised over a range of deposition parameters and doping levels. The beneficial effect of post-deposition surface treatments was also investigated. The emitter area has been increased from approximately 2cm2 to 36cm2. A theoretical model of the emission mechanism has been developed which explains many of the experimental findings. A resistive layer, capable of withstanding the later fabrication steps, has also been developed.Due to unforeseen technical difficulties, work was concentrated on triode emission devices. Two approaches to producing triode structures have been investigated - one involving the use of a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeting rogue DNA repair and genomic instability as novel toxicity mechanisms in C9orf72 ALS/FTD' to be submitted under Horizon Europe.

assistant: **Abstract**

Repeat expansions are a major cause of neurodegenerative diseases, but causal therapies are not available. A (G4C2)n repeat expansion in C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in Europe. Despite extensive research, the mechanisms linking these expansions to selective neurodegeneration remain poorly understood. Our project, epiC9repair, explores the novel hypothesis that genomic instability at the C9orf72 locus, driven by aberrant DNA repair and repeat-induced chromatin changes, is a critical factor in ALS/FTD pathogenesis. This project builds on our recent observation that the C9orf72 repeat is also a hotspot of DNA synthesis in post-mitotic neurons, and on recent findings in Huntington’s disease that cell type-specific somatic expansion of the pathogenic (CAG)n repeat drives neurodegeneration by unknown mechanisms.Using advanced CRISPR screens and innovative chromatin mapping techniques, we aim to uncover the DNA repair pathways that drive genomic instability in C9orf72 ALS/FTD and how these pathways contribute to neurodegeneration. In addition, we will investigate the role of epigenetic modifications in cell culture models and patient tissues, with a focus on identifying biomarkers that correlate with disease progression and regional neurodegeneration. These findings will inform studies in mouse models to test the therapeutic potential of targeting genomic instability. This multidisciplinary approach has the potential to transform our understanding of C9orf72-related diseases and paves the way for targeted therapeutic strategies that address the root causes of genomic instability in neurodegeneration.


**Keywords:** genomic instability, repeat expansion diseases, C9orf72, amyotrophic lateral s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metabolic engineering of glycopeptide antibiotics: technology, optimization and production' (MEGA-TOP).

assistant: **Innovation**

Biosynthetic pathways for selected glycopeptides will be analysed and optimized to mobilize the full potential of the actinomycete Cell Factory in the development and production of improved antibiotics. Glycopeptides are structurally complex molecules so their accessibility to chemistry is severely limited, but room for improvement has been demonstrated. In order to have an impact on the health of EU citizens, improved antibiotics need to be discovered and effectively developed. The objectives of this proposal are the development of effective tools for the engineering of bacterial producers of glycopeptides, the discovery of improved glycopeptide antibiotics and the rapid development of promising antibiotics through optimization of the production process. To achieve these objectives, this proposal gathers an inter-disciplinary team of academic and industrial partners, recognized leaders in the application of tools such as combinatorial biochemistry, biotransformation, protein engineering, artificial chromosomes, synthetic chemistry, molecular genetics, metabolic flux analysis, high throughput screening and medical microbiology.Most of the expected objectives and deliverables were achieved. We havea) completed the DNA sequences of three glycopeptide clusters;b) produced glycopeptide intermediates by genetic manipulation of producer strains;c) overexpressed active oxidases and glycosyltransferases;d) developed a gene transfer system for Nonomuraea and A. mediterranei;e) established a defined medium for Nonomuraea growth and mapped metabolic fluxes;f) implemented a HTS program for hybrid glycosyltransferases;g) generated novel glycopeptides by mutasynthesis;h) generated detailed information on parameters affecting A40926 production.Through these achievements, we can now ef
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Truly portable MRI for extremity and brain imaging anywhere & everywhere'.

assistant: **Concept**

Mobile medical imaging devices are invaluable for clinical diagnostic purposes both inside and outside healthcare institutions.Unfortunately, Magnetic Resonance Imaging (MRI), the gold standard for numerous neurological and musculoskeletal conditions, isnot readily portable. Recently, low-field MRI companies have demonstrated the first decisive steps towards portability within medicalfacilities and vehicles, but the scanners' weight and dimensions are still incompatible with more demanding use cases such as inremote and developing regions, sports facilities and events, medical and military camps, or home healthcare. Within the Histo-MRIand PR Scanner projects, we have recently demonstrated in vivo images taken with a light, small footprint, low-field extremity MRIscanner outside the controlled settings provided by medical facilities, including the first-ever MRI images obtained at a patient’shome, and even in open air connected to a gasoline generator. This has opened a path towards highly accessible MRI undercircumstances previously unrealistic.In this project we will take the necessary technical, industrial and entrepreneurial steps to tackle the massive deployment of low-fieldportable systems for point-of-care and bedside imaging in clinics large and small, home and hospice care, rural areas, sports facilitiesand events, field hospitals, or NGO and military camps, making MRI available to a large fraction of the world population with no orinsufficient access. To advance towards this highly ambitious goal, the objectives of the NextMRI project include: i) expanding thecurrent technology to both extremity and brain imaging; ii) improving the diagnostic capabilities with machine learning; iii)improving the portability and usability to meet end-user needs; iv) optimizing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Software Parallelisation with emmtrix Parallel Studio' in the context of a Horizon 2020 call.

assistant: **Objectives**

The introduction of multicore processors in 2005 enabled a wide range of computation-intensive real-time applications, in thePC and embedded sector. Especially high-performance embedded systems, as used in today’s automotive technologies(like driver assistance systems), in avionics but also in industrial automation, led to the rapid technological progress in thelast 12 years. However, while hardware development is progressing rapidly, software development is facing a majorchallenge: to make full use of the potential of multi-core processors, the software has to be programmed for parallelcomputational units and the required effort to do this manually is exponentially increasing with the number of cores available.As a result and in view of the current development to increase the cores available, manual software development for suchsystems increasingly becomes technically and economically unviable. emmtrix Technologies GmbH has the solution: withthe emmtrix Parallel Studio (ePS), software parallelisation can be automated, and the parallelisation effort can be reducedfrom several months to a few weeks or days. ePS is automatically realising the error-free implementation of parallelisationand rewrites the code. The tool supports the most common programming languages as well as model-based languages,such as those already established in the automotive industry. Both, the automotive industry (e.g. Bosch, Continental, BMW,ETAS) and the aviation industry (e.g. DLR, Airbus, GE Aviation) are already directly involved in the development of ePS viaa number of R&D projects. emmtrix plans the market entry with these industries. With market reports projecting for theembedded software market a CAGR of over 7% and a volume of €16.73 billion by 2024, the potential growth for emmtrix isenor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Child directed demonstration across cultures' in the context of a Seventh Framework call.

assistant: **Objectives**

Since the seminal work of Grice (1957), speaking is considered an intentional activity in the sense that it serves achieving goals: one of them, specific of humans, is to teach other humans to use new tools and knowledge (Tomasello 1999; Csibra & Gergely 2009). This context of interaction involves often children and this requires a specific type of recipient design mostly studied under the rubric of Child Directed Speech or Motherese. Even so in order for the message being effective, the adult has to employ a combination of strategies involving not only speech but also bodily movements with or without the objects involved (i.e., gesticulation, Kendon 1982). This project aims to conduct a fine-grained analysis of such communicative actions, namely demonstrations (Clark 1996), directed to children. In detail it proposes to investigate how demonstrations (with and without objects), with the speech they accompany, are sensitive to 1) the age of the addressee 2) the presence of the object 3) the culture of the speaker. The aim is to set up a study in which Italian and Dutch adults in their respective countries demonstrate the properties of a new object to a school age child and to another adult in two conditions: with and without the object. We predict significant differences between the child and the adult conditions as previous studies on ‘Motionese’ and ‘Gesturese’ shows. However despite the fact that Child-directed speech seems to have some universal features, we predict significant differences in terms of demonstrative acts between the two cultures, due to different gestural repertoires (i.e. Italy being a gesture rich culture). In general we will gain as the first time novel insights about culture specific demonstrative acts with and without objects-which are essential
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Emergent Properties to Improve Climate projections over Europe' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The North Atlantic Ocean has been shown to be 1) potentially predictable up to a decade ahead, 2) important in the predictability of other regions/indices e.g. European temperatures, Atlantic hurricanes, Sahel rainfall, and, 3) crucial to the manifestation of longer term climate change involving the large-scale ocean (e.g. the AMO/AMV; Atlantic Multidecadal Oscillation/Variability).Nonetheless, similarly to the widely considered “equilibrium climate sensitivity” (ECS; the long term temperature change in a climate model given a doubling of carbon dioxide levels), the spread in projections over the North Atlantic has remained large throughout IPCC (Intergovernmental Panel on Climate Change) assessment reports.In this project, we will investigate the causes of the spread in climate projections of the North Atlantic across IPCC-CMIP6 to derive emergent constraints that will allow better projections of climate change in Europe: We will (1) investigate the specific mechanisms of North Atlantic change in these models and compare with historical observations. This will lead to (2) testing how these comparisons are sensitive to the model formulation (via targeted experiments in two comparable state-of-the-art CMIP6 models from European institutions that use the same underlying ocean model). Finally, this will allow us to (3) derive emergent constraints to narrow the spread in CMIP6 projections.This project will combine the statistical power of the CMIP6 archive with the detailed process understanding obtained from targeted sensitivity experiments conducted within a coordinated ocean framework. Our goal is twofold: To understand the mechanisms behind climate change projections in the North Atlantic/Europe and to use this knowledge to derive emergent constraints with which to narr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Universality, Conflict, and Social Critique in Jean-Francois Lyotard and the Frankfurt School', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The project examines the tension between social heterogeneity and universal principles for political action and judgment through a comparative reading of the work of Jean-Francois Lyotard and the Frankfurt School tradition of critical theory. Frankfurt School critical theory and agonistic political theory influenced by French philosophy are predominantly read as two separate and mutually exclusive perspectives in political philosophy. This project traces a series of explicit and implicit discussions between Lyotard and the Frankfurt School in order to read both perspectives as different yet interrelated. The connections and contrasts between both perspectives are then used to develop a new framework to address three central issues within critical theory and political philosophy more broadly. Specifically, the project pursues three specific objectives: 1) To assess the possibilities and limitation of consensus and dissensus as grounds of universal political action and judgment, by means of a contrast between Lyotard and Habermas; 2) To understand the causes of social conflict as well as the role of critical theory is their articulation, by means of a contrast between Lyotard and Honneth; 3) To explain the sources of ideological extremism and determine the capacity of critical theory to respond to it, by means of a contrast between Lyotard and Adorno. Relying on a comparative methodology that involves intertextual reading, genealogical analysis, and intellectual history, the research will illuminate and generate dialogues between perspectives that are often considered separately from one another, thus improving our understanding of universality, conflict, and critique in heterogeneous societies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Data Interoperability Solution At STakeholders Emergencies Reaction' to be submitted under Seventh Framework.

assistant: **Abstract**

Emergency management becomes more challenging in an international crisis episode because of cultural, linguistic and legal differences between all stakeholders, especially first responders. Misunderstandings between first responders makes decision-making slower and more difficult. However, spread and development of networks and Emergency Management Systems (EMS) has improved emergency responses, becoming more coordinated. Despite improvements made in recent years, EMS have not still solved problems related to cultural, legal and linguistic differences which are the real cause of slower decision-making. In addition, from a technical perspective, the consolidation of current EMS and the limitations of their exchanged data formats offers another problem to be solved in any solution proposed for information interoperability between heterogeneous EMS surrounded by different contexts.To overcome this problem, a two step solution is proposed: (i) As main objective and foundations of this proposal, the development of a common and modular ontology shared by all the stakeholders offers the best solution to gather all stakeholders knowledge in a unique and flexible data model, taking into account different countries cultural, linguistic and legal issues (ii) Taking advantage of  the fact that most legacy Emergency Management Systems are based on Service-Oriented-Architectures (SOA), i.e. they collect information from services offered by other systems (e.g. Geographic Information Systems), the interoperability burden will be addressed by means of transparent SOA mediation algorithms compliant with current data formats and existing solutions.Taking into account the heterogeneity and diversity of all existing scenarios in crisis episodes, the potential results of this proposed ontolo