RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Stereochemical Dependent Clusteroluminescence from Thiol-yne Click Polymers' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Clusteroluminescence (CL) is a recently discovered phenomenon, in which ‘through space’ interactions in non-conjugated structures, can emit bright light (e.g. starch). Despite growing interest, the field still faces three major limitations: (1) it is unclear how to influence CL through structure–property relationships due to poorly defined spatial organization of CL luminogens within polymer chains and insufficient mechanistic understanding of the effect; (2) there is limited diversity in polymer systems that have been studied, with heavy reliance on natural products and commercial polymers rather than custom-designed architectures in studies to date; and (3) practical applications are, as yet, immature, thus limiting translation of CL into real-world use. To address these limitations, SCLP will establish the first quantitative structure–property relationship for CL polymers, enabling, for the first time, the rational design of new CL materials. The central objective is to achieve precise control over CL emission by manipulating polymer stereochemistry—specifically, cis/trans configurations—via sustainable thiol-yne click chemistry. This goal will be pursued through three integrated work packages: (1) synthesizing stereocontrolled polymers to unravel the fundamental photophysical mechanisms of CL; (2) engineering well-defined polymer architectures with tailored cluster size and density to regulate emission color and intensity; and (3), developing mechanoresponsive elastomers that exhibit reversible CL changes under mechanical strain for applications in smart materials. SCLP bridges a fundamental scientific gap transitioning from empirical observation to rational material design. It further supports sustainable innovation by leveraging green synthesis routes and holds si
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Translating Tudor domain splicing inhibitors for oncological applications' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In our effort to characterize metabolic activities in the cells nucleus, we discovered that the understudied Tudor domain protein SMNDC1 controls the repression of insulin in pancreatic alpha cells through its role as a splicing modulator. Based on this finding, we developed the first selective SMNDC1 Tudor domain inhibitors, for which we observe interesting preliminary data on insulin induction in primary human pancreatic islets. However, as a pan-essential gene expressed in most tissues, SMNDC1 is not an ideal therapeutic target in diabetes, where exceptionally high safety margins are required.Interestingly, independent findings published in a preprint established a role for SMNDC1 in cancer. These data show that SMNDC1 controls splicing of the ERK1 exon that bears the phosphorylation signal mediating RAS/RAF/MEK/ERK signaling. A significant fraction of ovarian and pancreatic carcinomas harbor SMNDC1 amplifications, and cells derived from these tumors depend on SMNDC1 both in vitro and in xenograft models. We here propose to evaluate the potential of our SMNDC1 inhibitors for cancer therapy. Experimentally, we will test these compounds in the ERK1 splicing dependent models in collaboration with the groups that described these findings, and we will profile their antiproliferative effects against a panel of >900 cancer cell lines. In parallel, we will conduct detailed analysis on the chemical scaffolds we discovered and develop a medicinal chemistry proposal to expand the scope of the filed patent application. Additionally, we will commission analyses for an optimal translation pathway of these compounds to the clinic, aiming an ideal positioning for certain cancer subtypes based on market size, competitive situation, clinical needs and trial design opportunities.Finall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Theoretical predictions of jet observables in QCD matter' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

A new state of nuclear matter, called quark-gluon plasma (QGP), is predicted to be created at extreme energy densities. This new state consists of interacting quarks, antiquarks and gluons. One of the major goals of RHIC (Relativistic Heavy Ion Collision) and LHC (Large Hadron Collider) experiments is to create and explore QGP. The main goal of this proposal is to develop a realistic theoretical formalism, which will be used to generate theoretical predictions that will be compared with the experimental data; such comparison will allow to map properties of this extreme phase of nuclear matter.Two major experimental observables, which are used to probe QGP, are suppression and elliptic flow of high energy particles (jets) that are created during collisions of relativistic heavy ion beams. These two observables are closely related with the energy loss of jets as they travel through QGP. In previous theoretical studies, jet energy loss was calculated under universally implemented, but highly unrealistic, assumption of static scattering centers. In her recent work, the candidate has successfully developed a theoretical formalism for heavy quark energy loss in a dynamical finite size QCD medium.  However, to develop a complete formalism of jet energy loss in such medium one also has to: i) accurately  calculate gluon energy loss ii) incorporate non-zero magnetic mass into the formalism iii) generalize the energy loss to all orders in the number of scattering canters. Achieving these three objectives is the first goal of this proposal. As the second goal, we will integrate the developed formalism into a computational framework, in order to generate the most accurate computational predictions of jet suppression and elliptic flow available up to now. These predictions will be d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Manufacturing process for ultimate performance inertial MEMS Gyroscope (MUPIA)' (MUPIA) under Horizon 2020.

assistant: **Objectives**

The main objective of the MUPIA project is to demonstrate a cost-efficient manufacturing process for a high end MEMS gyroscope for aerospace Applications. Both the sensor element and the packaging process is critical to achieve a precise, long term stable and reliable component. The consortium consist of SINTEF and Cerinnov, which together with sub Suppliers cover both the necessary silicon MEMS processing and the high end ceramic packaging technology needed to reach the goal of the project. SINTEF has worked with industrialisation of MEMS components since the 1960s. Despite being a research industry, SINTEF holds the certifications ISO 9001:2015, ISO 14001:2015 and OHSAS 18001:2007 and have a regular production of MEMS components for the petroleum, medical and aerospace industry. Cerinnov has expertise in laser processes for ablation and sintering. They will collaborate with a sub Suppliers with the development of the package for the gyroscope.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Reprogramming the reactivity of main-group compounds for capturing and activating methane and dinitrogen' (B-yond).

assistant: **Concept**

The activation of chemical bonds is fundamental to every chemical transformation. While reactions mediated by transition-metal catalysts are known for more than a century, the last decade witnessed spectacular developments in the emerging area of catalysis mediated by non-metallic species. Among these new chemical entities made from earth-abundant and inexpensive main-group elements, Lewis acid-base pairs and bifunctional element/ligand systems mimicking the behavior of transition-metals rapidly revolutionized the activation modes of chemical bonds.  In the project B-yond, I will establish new molecular engineering strategies and develop unprecedented main-group catalysts embedded in cage-shaped and curved molecular scaffolds. Ground-breaking molecules escaping the established structural theories will become the initial focus of my project, including the creation of non-planar B, Al, C and Si centered Lewis superacids with unmatched reactivities. I will push the frontiers of knowledge of chemical bonding by exploring unusual boron-elements bonding situations and advance the design of main-group catalysts beyond the state-of-the-art. Unprecedented C-H bond functionalization processes will be developed and exploited for hydrocarbons transformation through the concept of “low reorganization energy catalysts”. The activation of dinitrogen with unique main-group superacids and bases will finally be tackled, a pioneering step toward the uncharted territory of catalytic N2 activation and conversion without transition-metal complexes. These goals will be accomplished through a multidisciplinary approach built on my expertise in mechanistic investigations, spectroscopic and kinetics methods, organometallic and main group chemistry. The project B-yond will deliver extraordinary s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Optimizing gasification of high-ash content coals for electricity generation'.

assistant: **Innovation**

The OPTIMASH project aims to optimise the efficiency and reliability of gasifiers fuelled with high-ash content coals. High Pressure Circulating Fluidized Bed gasifiers are the target technology. The objective of this 4 years project is to develop a pilot gasifier capable of producing a syngas flow at 10 bars suitable for 1MWth. The gasification characteristics of high ash content coal will be investigated using pressurized Drop Tube Furnace facilities and accompanying measurement instruments. Coal gasification models will be developed taking into account the relevant chemical kinetics. In parallel, coal beneficiation and preparation studies will be conducted experimentally; the results will be modelled for their generalization.The 1 MWth pilot-scale plant will be modelled and numerically simulated using relevant CFD codes. The computations will be validated with data coming from the pilot-plant. The global IGCC system using the developed gasifier will be modelled using existing energy and mass balance soft-wares. Commercial scale design criteria will be developed taking into account pressure and geometric scaling.Indian high ash coals are the main target of the project. To insure the fuel flexibility of the developed process, Turkish high ash coals will also be studied and their characteristics used in the modelling of the process.The project will allow optimizing the global efficiency of the gasification technology for high ash coal by minimizing the steam use, optimising particle size vs residence time, developing particle agglomeration avoidance strategies, investigating corrosion risks, increasing fuel flexibility, developing efficient ash disposal system and testing different technologies for gas cooling, tar and fly ash removal. The consortium comprises a major i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Developing quantitative methods for estimating birth and death rates of immune cells using CFSE label' (CFSE), addressing dissemination and exploitation.

assistant: **Impact**

The regulation of cell division and survival is central to immune regulation, and traditionally the analysis of these processes has been qualitative and descriptive. Recently developed techniques that allow one to follow antigen-specific T and B cells labe led with the dye CFSE over time have stimulated renewed interest in lymphocyte kinetics. Despite the widespread use of this labeling technique in immunology, the proper interpretation of labeling data is difficult and requires analysis with appropriate ma thematical models. We propose to develop efficient mathematical methods to quantify the population kinetics of lymphocytes during immune responses based on the CFSE labeling technique. For this, we plan to use the published data and are collaborating with the laboratory of Dr. Philip D. Hodgkin (Walter and Eliza Hall Institute of Medical Research, Australia), the well-known expert in CFSE labeling technique, to obtain unpublished data on the dynamics of CFSE-labeled T and B lymphocytes in vitro and in viv o. These data will be analyzed using a series of mathematical models with increased levels of complexity. These different models will be used against the data to determine how well the models can describe the data and whether such models are biologicall y realistic. The main theoretical challenge here is to develop mathematical models that are both realistic and contain minimum parameters that can be reliably estimated from the labeling data. The proposed research will allow the coordinator (VVG) to imp rove his skills in developing mathematical models of immune cell dynamics, in application of these models to experimental data, and in learning different techniques of estimation of model parameters. The proposed research will likely result in development of a group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Emotional fit within and between cultural contexts: Analyzing natural language to describe and compare the conceptual system for emotions' (2014-2020).

assistant: **Concept**

The frequencies, intensities, and types of emotions people experience in a given situation differ systematically across cultural boundaries. This variation is inherently meaningful because it reflects differences in the conceptual system for emotions, with implications for well-being. Emotional fit between an individual and other members of their culture is a protective factor for mental and physical health, as is a well-developed conceptual repertoire for emotions. Although language is often used to understand the conceptual system for emotions, this work has remained limited by theories that focus on emotion words at the expense of other features of language, and methods that do not allow for discovery-oriented analysis. In this research project, I will address these limitations by describing the conceptual system for emotions in Dutch-speaking Belgians using a qualitative (objective 1) and automated (objective 2) analysis of natural language. I will then perform a cross-cultural comparison with English speakers from the US (objective 3), and derive a natural language-based measure of emotional fit between individuals and their fellow culture members (objective 4). To accomplish these goals, I propose a 2-year stay at Katholieke Universiteit Leuven under the supervision of Prof. Batja Mesquita, a pioneer in the study of culture and emotion whose ERC Advanced grant will provide key data for my project. I will also be supported by Profs. Peter Kuppens and Dirk Geeraerts, experts in individual differences and linguistic theory, respectively. I further propose a secondment with Dr. Ryan L. Boyd of Lancaster University, who will train me in state-of-the-art methods in automated text analysis. The deliverables of the project also include an article reviewing approaches to a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Wing assisted hydrofoil enabling technologies, hydrodynamics and aerodynamics'.

assistant: **Objectives**

Objectives and content The overall objective of SEABUS-HYDAER is to reach new levels of knowledge and technologies in hydrodynamics combined with aerodynamics, in waterjet propulsion, in high speed towing tank testing, in obstacle detection systems and in software tools for seacraft design. Most of these issues are R&D objectives in the Maritime Industry R&D Masterplan I (1.1.1, 1.1.4, 1.4.1, 2.2). Making these steps will enable the consortium to realise a new type of seacraft: the wing assisted hydrofoil (WAH). This new concept is based on cross-fertilisation of aerodynamics with hydrodynamics, combined with the promises found in the state-of-the-art of the other essential enabling technologies. The industrial need is based on a global need for efficient, economic, fast and safe (marine) transport. This project will add to the existing concepts presently under development, a very promising new concept. This concept is not the only innovation. Enabling technologies in the project are covered in such a way that the results of this work will be applicable in a range of marine transport concepts. This makes application of SEABUSHYDAER much broader that just the realisation of the WAH concept. SEABUS-HYDAER is an end-user driven project: several discussions with ferry-operators in Spain, Greece, Italy, Sweden and the United Kingdom have led to the operational specifications. One ferry operator is part of the consortium; several others together form the market feedback group, which will give feedback on the technical progress from an operational point of view annually. Major innovations are: the Wing Assisted Hydrofoil concept, capable of speeds of up to 120 knots at a 20% lower fuel consumption / payload / mile than the presently available high speed ferries that operate at
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'A bioartificial brain with an artificial body: training a cultured neural tissue to support the purposive behavior of an artificial body'.

assistant: **Objectives**

NEUROBIT intends to develop the tools and technologies for connecting portions of living nervous tissue (cultured, and kept alive in-vitro) bi-directionally with external devices (i.e., a robot) in order to teach the biological component of the hybrid system to process information in a goal-oriented way. This will open to new opportunities of using engineered neurobiological units to process information in a natural and therefore, more intelligent way, and to study how simple, natural but at the same time artificial (i.e., bioartificial) systems code the information. The somewhat revealed, neural code could then also be utilised as a source of inspiration for new artificial systems (i.e., new algorithms and new neuromorphic physical devices).OBJECTIVESFunctional plasticity seems incomparably greater in the brain than in any artificial system. Especially its capability to adapt its performance to previous experience is a major challenge to scientists for understanding the underlying principles and operations, a necessary step toward implementing these same principles in physical devices. The main goal of the project is to take advantage of these unique plastic properties to control the sensorimotor behaviour of an artificial body moving in a changing environment. As living highly adaptable systems, we will use networks of neurones kept alive, in-vitro, out of the brain of mammalian embryos. The living network will be real-time connected.DESCRIPTION OF WORKA system based on a cultured neuronal network chronically coupled to a robot will be set-up. The bioartficial neuronal device will be used to drive the autonomous robot, equipped with one or more sets of sensors (light, acoustic, range, etc). Sensors will drive the stimulation of the microtransducer inputs, whereas the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Energy and comfort control for building management systems', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

The objective is to develop a new generation of control devices for solar shading systems, glare control systems, electric lighting and HVAC systems for the simultaneous optimisation of building energy consumption and comfort. They can reduce the peak-cooling load to less than 50% above the average value and reduce the total annual building energy consumption. Data on the angle-dependent measured or calculated thermal and optical properties of the facade elements will be stored in the controller, allowing it to take them into account in an intelligent" way. Glare criteria for objects producing bright light spots will be developed, which can be used for control purposes. A new device for bi-directional measurement of localised luminance peaks will be developed. A design tool will predict the energy impact of different control strategies and the frequency of occurrence of visually or thermally uncomfortable situations."