RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DETERMINISTIC E2E COMMUNICATION WITH 6G', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Digitalization is transforming industries and society with the adoption of edge/cloud computing, AI and digital twins. In the future, physical processes, collaborating machines, but also novel human-system-interactions will move towards a cyber-physical continuum merging the physical world of senses, actions as well as their digital programmable representations. Fundamentally new requirements for deterministic communication with predictable performance will appear for such cyber-physical end-to-end services. Wired deterministic communication standards have already emerged including Time Sensitive Networking (TSN) and Deterministic Networking (DetNet), while 5G has specified mechanisms for interworking with those standards. However, the available support of 5G in conjunction with TSN and DetNet is not sufficient for future end-to-end time-critical applications. Driven by pivotal use cases from Industry 5.0, DETERMINISTIC6G addresses three central challenges of future deterministic end-to-end communication enabled by 6G: (1) a new architecture for 6G systems providing predictable performance and integrating it end-to-end with TSN and DetNet; (2) novel data-driven awareness of stochastically evolving network performance, with time synchronization over heterogeneous domains; and (3) leveraging novel digital twins of both 6G networks and cyber-physical systems, to anticipate situational circumstances impacting determinism of networks and safety of cyber-physical systems. DETERMINISTIC6G will also devise security-by-design for deterministic communication including the integration of edge computing and the support of OPC UA into deterministic network paths. The project targets dissemination of results towards the three essential standardization bodies in this domain: 3GPP (for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Seafaring Lives in Transition. Mediterranean Maritime Labour and Shipping during Globalization, 1850s-1920s.' (SeaLiT) under Horizon 2020.

assistant: **Objectives**

SeaLiT explores the transition from sail to steam navigation and its effects on seafaring populations in the Mediterranean and the Black Sea between the 1850s and the 1920s. In the core of the project lie the effects of technological innovation on seafaring people and maritime communities, whose lives were drastically altered by the advent of steam. The project addresses the changes through the actors, seafarers, shipowners and their families, focusing on the adjustment of seafaring lives to a novel socio-economic reality. It investigates the maritime labour market, the evolving relations among shipowner, captain, crew and their local societies, life on board and ashore, as well as the development of new business strategies, trade routes and navigation patterns.Maritime labour and shipping remains an understudied case of the transition from the premodern working environment of the sailing ship to that of the steamer, in a period of rapid technological improvements, economic growth and market integration. Therefore, the project will address a major gap in maritime historiography: on the one hand, the transition from sail to steam, and on the other, the Mediterranean and the Black Sea, “the extended Mediterranean” according to F. Braudel.    The project examines in a comparative approach seven maritime regions: the Ionian, Aegean, Tyrrhenian, Adriatic and Black Seas, Spain and southern France. The research team composed of the PI, three postdoctoral fellows, four senior researchers and four Ph.D. candidates from Greece, Italy, Spain, France and Ukraine will study unpublished sources: ship logbooks, crew lists, business records, and private correspondence. They will produce a collective volume, several articles, a final synthesis by the PI, four Ph.D. dissertations, three
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Inaudible SMART CROWDS SECURITY through existing loudspeakers”' (Zoovel-UC) under Horizon 2020.

assistant: **Objectives**

Zoovel Ultrasound Connectivity (Zoovel-UC) project is a D2D  connectivity to raise the safety and security in crowded areas such as sports stadiums, concert halls, open space events, subway, etc. providing real-time crowd management. Zoovel-UC technology performs direct and selective communication to the spectators and utilizes geospatial intelligence to shift the flow of fans and minimize crowds in real-time, improving the efficiency of current security protocols. Since the attack on the Twin Towers in 2001, terrorism has been on our collective unconscious as the main threat to security. The recently attacks happened in Paris and Brussels again reminded the vulnerability of the international security system and the difficulty to deal effectively with this type of unconventional threat. Crowd events provide a potential target for terrorist activity, besides they are susceptible to other various threats, such as natural disasters, crowding and fan violence. With the uncertainty of terrorist actions and fan behaviour, it is impossible to ensure a risk-free environment at crowd venues. It is therefore a matter of how event organizers prepare, respond, and recover to mitigate the consequences of emergencies. Good countermeasures and contingency planning can protect crowd areas from disruption and ultimately enhance spectator confidence.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Standards compliant framework to support complete integrated product life-cycle information Management And electronic commerce foR the furniture manufacturing (FM) industry, in THE advent of the smart enterprises' (FM).

assistant: **Innovation**

Based on the number of people it employs, the furniture industry is the largest manufacturing sector in the world, and in Europe in particular. To keep its competitiveness, Europe needs to accomplish rapidly the new requirements for the furniture industrial sector in the e-global marketplace. SMART-fm project establishes a Thematic Network organised in 5 inter-coordinated Working Groups to harmonize and demonstrate to the furniture industry the state of the art and trends in Standardisation and Research in complete integrated Product Life Cycle (PLC), intelligence e-business and extended enterprise practices. Network members and furniture related companies are the major receivers of SMART - fm results. They will be the basis to stimulate companies to adopt the project results and the research community to move beyond.Objectives:The general objective is to stimulate and accelerate furniture-related companies in the advent of e-business, extended enterprises and intelligent services, to adopt technologies and practices preparing industry and researchers to advance on the state of the art, identifying requirements to move beyond and reach the future vision of furniture manufacturing business. Specific objectives: Propose a new modular and extended ISO Application Protocol, to support the complete integrated Product Life Cycle for the furniture industry manufacturers. Develop e-business services taxonomies, following a previously adopted technical methodology. Co-ordinate the international developments towards the IT-support for extend sector terminology. Harmonise and demonstrate to the furniture industry the state of the art and future vision in Standardisation and Research of complete integrated Product Life Cycle, e-business and extended enterprises. Study and report on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Depression in diverse populations: Unravelling the interplay between genes and environment' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Depression affects 300 million people and represents one of the biggest challenges to human health to date. Of the burden, 80% pertains to low- and middle-income countries. It is thus imperative to understand the global causes of depression to design effective targeted interventions. DIVERGE will build the first ancestrally diverse data resource for depression, generated from biobanks (N=1.8M) and new studies in Pakistan (N=20K) as well as sub-Saharan Africa (N=13K) with deep phenotyping and genotyping.Differences in depression risk between populations have been shaped by the environment, demography and diverging evolutionary history. Using the novel perspective of evolutionary psychiatry, DIVERGE will comprehensively characterise the genetic architecture of depression and assess how it has been shaped by natural selection. Thereby, I will illuminate how heritability, environmental factors and their interplay affect disease development. I will develop a new method, trans-ethnic colocalization, to address the fundamental question whether genetic risk factors are transferable across populations. This is important to ensure that health benefits of precision medicine can be shared within and across populations.In addition to the big picture approach, I aim to identify specific causes of the disorder. The diversity of the data together with the application of population-matched inheritance models will empower the discovery of novel genetic loci for depression. I will develop and apply cutting-edge methods, including trans-ethnic fine-mapping with functional annotations to uncover biological mechanisms underlying depression loci. Trauma, such as exposure to violence, is a strong risk factor for depression. DIVERGE will investigate the interplay between traumatic life events a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Students grants for RAPHAEL EUROCOURSE' (STUGRANTS) under Sixth Framework.

assistant: **Objectives**

The dissemination of knowledge from research projects to students and young engineers is one of the key points of the education and training activities in the 6th framework programme projects. Within the RAPHAEL project (contract number: 516508) the organisation of a EUROCOURSE has been selected as the appropriate tool for Education and Training" activities.A EUROCOURSE is also planed in the proposed PUMA project. Because of the strong links between the two projects it is planed to combine both courses. To put students in the position to participate in the EUROCOURSE it will be necessary to refund at least part of their expenses for travel and accommodation. So we ask the commission for grants to fund students who are participating in the EUROCOURSE.The course itself will be organised by the RAPHAEL project (contract number: 516508) in conjunction with the PUMA project. Concerning the academia, the main partner of the "Education and Training" activities in RAPHAEL is the European Nuclear Education Network association (ENEN), but also students from other universities and research centres will be invited to attend the EUROCOURSE. This project should be regarded as supplement to the "Education and Training" activities of both projects, so only the organisational tasks of student registration and grant distribution are part of this project."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Modulation of a novel population of immune suppressive tumoural macrophages and the therapeutic vaccination of cancer'.

assistant: **Concept**

The therapeutic vaccination against breast cancer, and more widely all solid tumours, has largely been ineffective in clinical trials. This failure has been attributed to ‘immune editing’ of the cancerous cells, or to suppression of T cell functions within the tumour. In relation to the later, we have identified a novel population of tumoural macrophages, marked by the expression of fibroblast activation protein-alpha (FAP) which can mediate tumoural immune suppression through the enzyme heme oxygenase-1 (HO-1). Selective inhibition of HO-1 with tin mesoporphyrin (SnMP), a drug which has already been administered to infants for the treatment of neonatal jaundice, permits immunological control of tumour growth in transplantable Lewis lung carcinoma tumours. This proposal seeks to evaluate SnMP as a novel cancer immunotherapy for the treatment of breast cancer. We have demonstrated that HO-1+ cells are recruited into mammary tumours of a relevant spontaneous murine model of breast cancer. A vaccine strategy will be developed targeting telomerase, a vaccine target already in clinical trial for human breast cancer. The effect on mammary tumour growth of a vaccine induced anti-tumour immune response, alongside HO-1 inhibition to alleviate immune suppression, will be assessed. Lung metastases in these mice, and their response to treatment, will also be studied. The HO-1 expressing cells in human breast cancer will be quantitated and characterised at both the protein and transcriptome levels to validate the approach. Novel immuno-therapies directed at modulating HO-1 expression will also be investigated, facilitated by the development of a transgenic HO-1 reporter mouse which will co-express green fluorescent protein and luciferase driven by the promoter and response elements
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Corporate research for the development of a reliable tyre pressure monitoring system'.

assistant: **Concept**

The proposal describes an effort that focuses on making driving safer while improving vehicle's safety efficiency. The main idea is to provide the driver with a warning signal in case the tyre air pressure deviates from a normal predetermined range of values. The system is based on a capacitive coupling between rotating and non rotating metallic annular strips. An electronic circuit produces an output, whenever its input falls below a certain level, which drives an indicator to warn the driver. Installation of such a system on any vehicle, especially on big long trucks with twin tyres, could contribute a lot on road accident reduction. Furthermore, tyres with proper air pressure could offer fuel economy, prolong the tyre life and provide confidence to the driver. Patents have been issued for the device from USA, AUSTRALIA and EPO (General European and Seven National Patents) while patents from CANADA and JAPAN are currently pending. It is estimated that the duration of the project will be 24 months. A period of 6 10 months will be required prior to manufacture and subsequent commercial exploitation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Interactions, Spins and Edges in Optical Lattices with Topological Band Structures' (ISOTOP) targeting Horizon 2020.

assistant: **Abstract**

Electrons in a magnetic field experience a drift transverse to their velocity, which gives rise to intriguing effects such as the whole family of Hall Effects. Interestingly, this drift can also appear without a charged particle and without magnetic field, i.e. for ultra-cold quantum gases in optical lattices with non-trivial topology, described by a Berry curvature. This enables researchers to use the tunability of quantum gases and allow for studies beyond the possibilities of condensed matter systems. Furthermore, it allows to mimic and study in great detail fascinating effects such as topological insulators and edge-states. Especially, the interplay between topology and interactions is not well understood and the existence of many interesting states, such as topological insulators, fractional Chern insulators and topological superfluids, is predicted, but have not yet been observed. In recent years, great progress has been made in engineering topological band structures for quantum gases. Whereas theoretical proposals are well developed, so far there are only few experimental realizations of topological band structures, especially for fermionic quantum gases. In this action, we want to create non-trivial topological band structures and explore (many-body) phases that can emerge for fermions and mixtures of bosons and fermions. We will map out the Berry curvature and study the detection of edge states, which provides a clear signature of a non-trivial topology. For the first time, we will realize a new creation and detection method for topological band structures and study high spin Fermi systems in topological optical lattices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hydrogel Biodegradable Ureteral Stent' in the context of a Horizon Europe call.

assistant: **Objectives**

Hydrumedical S.A. (HYD) team is composed by a urologist and biomaterials scientists that will revolutionise the treatment of ureteral disorders. Hydrustent is a biodegradable, hydrogel-based, soft, lubricated, and flexible stent. These properties prevent bacterial adhesion (>80% of the stent-related complications) and encrustation development. Nowadays, the application of stents requires a 2nd removal procedure, a burden for patients and healthcare systems. Hydrustent is homogeneously degraded by the urine flow within 7-10 days, eliminating the need of further interventions for its removal. Hydrustent will bring huge health benefits for patients and reduce up to 60% of treatment costs (4.3B€ savings for the health system in EU+US). Validated by the urology community, with a global Ureteral Stents Market raising (~604M€ by 2030), if Hydrustent project is successfully implemented, we intend to reach the EU market in 2024 with profits amounting to 25M€, 5 years after product launch.


**Keywords:** Biodegradable,Biocompatible,Natural-origin polymer,Patient care,Health-related biotechnology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Polymeric cyclodextrin-based nanoparticles for combination therapy of castrate-resistant prostate cancer'.

assistant: **Objectives**

Prostate cancer (PC) is the fifth leading cause of cancer-related death worldwide. PC often presents in its Multidrug resistant form leaving the patient few survival chances. New approaches are required to overcome resistance-related problems in PC and nanomedicine holds a lot of premises to effectively contribute in this battle. In this frame POLAR STAR aims at the implementation of combination therapy to treat castrate-resistant PC. Our strategy is to exploit innovative nanotechnology to administer contemporarily different therapeutic agents that synergically exert their activity across multiple oncogenic pathways. We plan to use new mixed polymers based on biocompatible cyclodextrins as these building blocks are already FDA approved. Simple organic chemistry is pursued to implement target selectivity and in vivo tracking of the polymeric nanocarrier. The design is guided by the final goal, the future clinical application of nanocarriers to improve PC treatment, keeping in mind upgrade of the nanocarrier systems to large scale production. We will focus on the latest PC drugs suffering from side effects and emerging resistance as multiple cargo to be loaded. Full chemico-physical characterization of the systems is planned as well as assessment of the efficacy of loaded nanocarriers in cell cultures with different drug responsivity profiles. In order to reduce animal experiments POLAR STAR will take full advantage of 3D prostate tissue models for biological tests, an apporach at the forefront in drug design. We plan to reach our goal bringing together the expertise of the fellow and the supervisor supported by the private and academic teams hosting the fellow during secondments.  POLAR STAR creates a multidisciplinary environment where all actors, public and private, wi