RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'AeronautiCal Cyber INtrusion dEtection mechanism' (2014-2020).

assistant: **Concept**

ATC use of datalink is widely expanding over the years. Data communications are a key enabler sustaining SESAR/NextGen services, deployment being planned in the 2020+.  Legacy data transmission is not encrypted for existing datalink capabilities and protocol.  As a consequence, it is very hard to identify if failure is a malfunction or an attack.However, civil aviation is an increasingly attractive target for cyber-attacks. New technologies such as e-enabled aircraft and modern CNS/ATM systems, together with trends towards greater connectivity, reliance on technology, common infrastructure underpinned with common technologies with common standards, etc. … are changing the risk landscape of the aviation system.The consequences of a potential cyber-attack in civil aviation are wide and can include: (i) Lost of trust in new systems & concepts, limiting their successful deployment;(ii) A 'domino effect' of failures across connected systems or common components;(iii) Closure of the air traffic management system for unpredictable periods; …Since there is not a 'silver bullet' technology that will secure the aeronautical domain,  it is essential to:(i) Investigate measures to make the current systems more resilient against cyber-threats(ii) To establish effective and automated solutions for intrusion detection; (iii) Promote its implementation worldwide and build trust across stakeholders.Considering aforementioned challenges, the vACCINE Project aims to design an aircraft onboard security filter with an accuracy level of intrusion detection compatible with cyber protection objectives. The objective is to check/control data from the ground domain before authorizing them to enter the avionics domain not to compromise this level of safety.Based modern digital transformation conc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'IMPROVEMENT OF EFFICIENCY AND REDUCTION OF APPLICATION RATES OF PREFERABLE NATURALLY GROWN BIOCIDES BY COMPLEXATION WITH GAMMA-CYCLODEXTRIN' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

In accordance with the reformed Common Agricultural Policy (CAP) this projectsuggests the use of gamma-cyclodextrin (CD) in biocides. Two biocides, scilliroside(extracted from hyacinth) and pyrethrins (extracted from compositae), will becomplexed with gamma-CD in order to improve their biological activity (hencereducing the application required) as well as to stabilize these biocides againstdegradation.As a part of the European CAP programme agricultural areas are set aside. We feelone side effect of this policy may be increased population of rodents and insects.Plant based scilliroside and pyrethrins offer new possibilities to control highinfestations of rats and mice or insects.Biogenic pyrethrins are sensitive to sunlight and will be decomposed within a fewhours of outdoor use. However, gamma-CD complexed pyrethrins are stabileagainst sunlight and temperature and could therefore be used for pest control inmajor field crops. The saving of normally necessary synergists (e.g.piperonylbutoxide) is also expected. For environmental reasons this new biocidewould be a significant step forward for farming systems and stock protection inEC-member states.New extraction techniques with gamma-CD are suggested to yield pure scillirosideand pyrethrins from plant raw material in a single step. In comparison toconventional extraction methods the use of organic solvents and mineral oils isreplaced by highly degradable cyclodextrins. This new environmental friendly andcheap method could support developing countries in their production of pyrethrins.The method could also be applied to Europe aiding in a diversification of farmingsystems.In accordance with this programme our proposal suggests an opportunity tosignificantly reduce application rates of biocides, designs innovative methods
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Human-centred Rapid Reconfiguration of Production and Value Chain in Fast Changing Scenarios' (RaRe2) under Horizon Europe.

assistant: **Objectives**

The global objective of RaRe2 project is to create a flexible and resilient Holistic Ecosystem Platform, enabled by the interaction among many European organizations cooperating in the fast reconfiguration of process chains, through collaborative systems and adaptable workforce upskilling. RaRe2 will help make the European manufacturing landscape sustainably robust to unexpected market change, sudden disruption, legal change, or every kind of crisis and changing scenario including climate and weather related. RaRe2 has set strategic and operational objectives, which include innovative digital solutions and knowledge about standards and methodologies, which can support the quickness in reconfiguration and certifications at early stages. RaRe2 will enable the generation of a green wave that will early detect an upcoming issue, alert the decision maker, quickly propose simulations about potential new destinations (adjacent reasonable sectors and products), new routes (how to produce it, with internal reconfiguration and supply chain involvement), the plan to put the change in place, the expected speed of each connected node of the new route, robustness. Key pillars: i) AI-based early detection of reconfiguration needs, from internal and external sources; ii) rapid adaptation of products, processes and supply chain to the changed situations; iii) empowering and upskilling humans, supporting decision makers to make fast and concrete decisions and quickly ramp up of the workforce. RaRe2 will be exploited to create a strong and reliable network of organizations interested in cooperating in rapid reconfiguration events, able to take into account social, market, legal, sustainability and economical factors. The consortium is based on 22 European partners, which will develop and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Appraising and accelerating theoretical progress in memory modification research with meta-science, Bayesian statistics, and an open-collaborative approach.' (AAT).

assistant: **Innovation**

This fellowship will involve appraising and accelerating theoretical progress in memory modification research with Bayesian statistics, collaboration, and open science. I have proposed an ambitious and innovative research agenda that complements my existing knowledge and skillset (memory modification, meta-science, open science) with the expertise of my prospective supervisor (Bayesian statistics, open science, collaborative science). Theoretical progress in the field of memory modification has stalled due to problems with the credibility of the published literature. Issues include small sample sizes, a lack of transparency, and low theoretical diagnosticity. Additionally, the predominant use of frequentist statistics limits opportunities for informative statistical inferences, particularly quantifying evidence for the null hypothesis. The proposed research will involve a systematic appraisal of the memory modification field using Bayesian statistics and a consortium project based on open science principles to accelerate theoretical progress. The procedures developed could be usefully extended to other research areas through collaboration with domain experts. This research agenda will provide me with ample training opportunities to develop a strong repertoire of statistical, methodological, and transferable skills. I will be in an excellent position to enrich my unique research portfolio and publish research outputs in high quality open access outlets. The mobility and reintegration aspects of the fellowship will be especially beneficial in helping me to consolidate existing European collaborations and develop new professional relationships in the Netherlands’ burgeoning meta-science network. In sum, the fellowship will provide me with the training and opportunities I n
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Process improvement experiment in re-use' in the context of a Fourth Framework call.

assistant: **Objectives**

Delivering competitive software solutions requires increasingly efficient use of resources. One key way of achieving this is to apply re-use in as many areas as possible. With the effective application of re-use similarities between projects can be exploited to avoid re-working. In addition, complex projects can be simplified by breaking them down and identifying where previously tried and tested components can be applied to provide rapid and high quality solutions.The key objective of this experiment is to build a framework in which BYG is better able to deliver customers quality solutions in a cost effective and efficient manner.THE EXPERIMENTTo achieve the objective the experiment will investigate the creation, maintenance and use of different resource libraries to include software modules (applying Object Orientation, C++ and Java), application code (authored multimedia scripts), multimedia resources (video, sound, images etc.) and documentation (specifications, user documentation, training materials etc.). The various library management tools/techniques investigated will be complemented by developing effective management of re-use. The baseline application is the development of the next generation of PC-based multimedia authoring tools, involving approximately 12 of BYG's 35 total staff.EXPECTED IMPACT AND EXPERIENCEBYG's staff will gain valuable practical exposure to concepts of re-use and how to apply them in their work, be it software development, testing, application programming or generation of documentation. The small trials using various library management techniques will be extended throughout the company, including into its other core business in 3D simulation technology. The appointment of a formal Quality Assurance Management function in the company will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microbial Isoprene Cycling Response in the Arctic', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Isoprene is a volatile organic compound (VOC) that accounts for more than a third of the total VOC emissions from ecosystems into the atmosphere. This VOC, primarily released by plants, is emitted at a rate of ~550 Tg/y and can significantly influence atmospheric chemistry and climate. Despite some knowledge of isoprene degradation in temperate regions, its role in Arctic ecosystems and the impact of global changes such as rising temperatures and drought remain poorly understood. The Microbial Isoprene Cycling Response in the Arctic (µ-Arctic) project, supervised by Professor Riikka Rinnan at the new Center of Excellence, Center for Volatile Interactions (VOLT) at the Department of Biology in the University of Copenhagen, aims to bridge these knowledge gaps. My objectives include isolating and characterizing active isoprene-degrading bacteria from Arctic plant phytobiomes, quantifying isoprene dynamics in Arctic mesocosms, and understanding the influence of elevated temperatures and drought on isoprene cycling rates. This research will leverage my expertise in targeted cultivation-dependent and independent methods, including Stable Isotope Probing (SIP) for DNA sequencing and metagenomics to provide more accurate insights into isoprene degradation. The outcomes of this study are critical for improving our understanding of Arctic isoprene cycling, which is becoming increasingly relevant due to climate change-induced temperature rises and their potential impact on atmospheric VOCs.


**Keywords:** Environmental microbiology, Microbial ecology, DNA-Stable Isotope Probing, Isoprene, Volatile Organic Compounds (VOC), Soluble Di Iron Monooxygenases (SDIMOs), metagenomics, mesocosms, global warming
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Measuring the electron's electric dipole moment using ultracold molecules' in the context of a Horizon 2020 call.

assistant: **Objectives**

New fundamental particles at high energy scales that have not been reached by the Large Hadron Collider (LHC) could explain the observed matter-antimatter asymmetry that cannot be understood by the Standard Model of particle physics. These hypothetical particles, if they exist, will introduce a tiny electric dipole moment on the electron (eEDM), which can be probed by extremely sensitive measurement of the electron spin precession in a huge intra-molecular electric field. Previous eEDM measurements using relatively warm molecules are all consistent with zero and are mainly limited by spin coherence and interogation time. Here we propose to measure the eEDM using ultracold molecular beams. We will apply polarization gradient cooling in the two transverse directions to reduce the temperature to below 50 microkelvin. This will significantly increase the number of molecules that can be detected in the forward direction and improve the coherence. We will also develop a new deceleration technique for molecules, called Zeeman-Sisyphus deceleration, to reduce the forward velocity of the molecules to below 30 m/s that allows around 0.1 s interogation time, 100 times longer than the longest in the current beam experiments, in the measurement apparatus. Together with other improvements on molecule production, initial state preparation, magnetic field shielding and control, and spin state detection, we expect that the eEDM can be measured at least 10 or 100 times more precisely than the state-of-the-art level. This will be a search for new particles responsible for matter-antimatter asymmetry and a test of new physics beyond the Standard Model up to a few 100 TeV. This energy range extends far beyond the kinematic reach of any existing and near-future particle colliders and lies ar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Singularities in General Relativity' (SINGinGR).

assistant: **Innovation**

One of the outstanding open mathematical problems in General Relativity is to understand how singularities form in solutions to the Einstein equations. Singularities are typically found in the interior of black holes or at the Big Bang. The main objective of this proposal is to start a research group at the University of Crete that will develop novel mathematical techniques, combining ingredients from analysis, partial differential equations, and differential geometry, which will enable us to prove the formation of singularities in various new settings and test long-standing conjectures in the field.Dynamics of Big Bang singularities. In vacuum, the generic cosmological singularity is conjecturally spacelike, local, and oscillatory. The only rigorous evidence in favor of the latter scenario is restricted to homogeneous solutions. We intend to construct Big Bang singularities containing spikes or oscillations, without symmetries and analyticity, that test the conjectural picture. Here, previous work of the PI with J. Luk constructing Kasner-like singularities will be useful, since they are the building blocks of more complicated scenarios. We also intend to dynamically study the submanifold of Big Bang singularities having no oscillations, by advancing techniques recently developed in work of the PI and collaborators to prove stable Big Bang formation in the sub-critical regime.The black hole interior problem. The stable phenomenon that has been observed so far in black hole regions is Cauchy horizon formation. Our goal is to show that in certain regimes, a similar situation to that of Big Bangs occurs, where part of the inner black hole boundary is spacelike and singular. We consider the Einstein-massless-scalar field system, as well as the classical Oppenheimer-Snyder
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Silent flagellin in chronic inflammatory and auto-immune disease' (SilentFlame) under Horizon Europe.

assistant: **Objectives**

The last century has seen a dramatic increase in the prevalence of chronic inflammatory and autoimmune illnesses, including diseases of poorly understood etiology such as Crohn’s disease (CD) and myalgic encephalomyelitis (ME). Recent reports for CD and ME of elevated levels of antibodies against flagellins made by Lachnospiraceae (Lachno), which are usually associated with health, suggest a common breakdown of immune tolerance. My laboratory recently discovered a new class of flagellin that we termed “silent” because it binds the innate immune receptor TLR5 without inducing a response. Many Lachno species, which are highly abundant and prevalent in the human gut microbiome, encode silent flagellins. We have observed that silent flagellin is highly targeted by antibodies in CD and ME. We hypothesize that the usage of silent flagellins by Lachnos and their reciprocal interactions with host immunity sustain inflammation in the gut and may drive auto-immunity. In SilentFlame, we will explore the breadth of the antibody response against Lachno flagellins in a panel of chronic inflammatory and autoimmune conditions, as well as potential cross-reactivity with human proteins. In parallel, we will investigate the enigmatic role of silent flagellin in bacterial colonization of the gut and host adaptive immune responses, both in homeostasis and inflammation. To do so, we will establish new genetic systems for two Lachno bacteria commonly associated with human health and perform experiments in a germfree transgenic mouse line expressing the human TLR5, as well as human intestinal organoids to account for human specific effects. This research will advance basic understanding of host-microbe reciprocal interactions in homeostasis and chronic inflammation. The knowledge gained will e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Impact of cell shapes on cell behaviour and fate' (SHAPINCELLFATE) targeting Horizon Europe.

assistant: **Abstract**

Cells are often depicted as irregular spherical objects - the shape they adopt in suspension. However, the packed environment of tissues alters this simple shape, causing large cell deformations. This occurs during normal tissue growth and is even more pronounced upon tissue overgrowth, as in the case of solid tumors. Cell shape changes frequently occur in migratory cells, such as immune cells that patrol the organism within interstitial tissues, and cancer metastases that escape from the primary tumor to invade healthy tissues. In all cases, cells adapt and survive even to very large deformations. The mechanisms underlying such response and the long-term consequences that repeated cell shape changes have on physiology and pathology remain largely unknown. We have observed that changes in the shape of cells and organelle(s) induce reversible and irreversible modifications in their behaviour and function(s). We hypothesize that cells use such mechanisms to integrate the successive deformations of distinct amplitudes and durations that they experience during their lifetime. This implies the existence of “shape-induced memory effects” that not only encode the geometrical and mechanical history of the cell but also dictate its fate. Here, we propose to tackle the molecular mechanisms and physical principles accounting for shape-induced memory effects and to evaluate their impact on immunity and cancer. We will focus on two cell types that undergo large shape changes in vivo, and communicate to establish cancer immunity: (1) dendritic cells, which initiate adaptive immune responses, and (2) cancer cells derived from mammary epithelia. Our project will reveal whether boundary conditions imposed by physical confinement are overarching determinants of cellular behaviours at dif