RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'High throughput integrated technologies for multimaterial functional  Micro Components' (HINMICO).

assistant: **Innovation**

Volume production at industrial scale of miniaturised multi-material 3D (polymer-polymer, metal-polymer, metal-metal, polymer-ceramics,...) still face important challenges to be affordable by SMEs. Challenges not only in terms of precision manufacturing (precision engineering <0.01%) but also in the adequate interaction between the different constituent materials.Besides multi-material micro-system manufacturing processes still show to be time and cost consuming mainly from assembling activities and back en processes (35-60% of the total manufacturing costs come only from the assembling), so further research efforts in alternative and more integrated manufacturing concepts(over-moulding of micro-components and in-mould assembly technology would avoid the assembly step) are needed.To answer those problems the development of high-throughput and cost-efficient process chains based on micro injection should consider the following aspects:• Improved volume production, not only from the standpoint of the necessary accuracy and performance of the process, but also regarding the interaction/bonding of the different materials which make up the produced parts and the possibility of selective functionality of their surfaces.• The integration of the different processes including the feeding and handling systems for automatic operation in order to eliminate human intervention and manufacturing costs.• Analyse the most suitable process control, online verification and back-end processes taking into account the features of the multi-material replicated parts represented by five demonstrators.The aim is to reduce manufacturing costs up to 40%. Thus, the HINMICO project final outcome will enable to produce high quality multi-material micro-components through more integrated, efficient a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Dynamics And Mechanism Of KLU-Signalling In The Control Of Plant Organ Size' (DAMOKLUS).

assistant: **Innovation**

How growth in plants is controlled to generate organs with a species-specific size and shape is a fundamental question of developmental biology. The Arabidopsis KLU gene, encoding a putative cytochrome P450, controls the timing of proliferation arrest in growing primordia and thus regulates cell numbers and organ size. KLU acts in a non-cell autonomous manner by producing a mobile growth factor. Its restricted expression pattern at the periphery of organ primordia suggests a model whereby this downstream signal is used to measure the size of the growing primordium and coordinate the arrest of cell proliferation: As the KLU expressing region grows more slowly than the organ as a whole, the downstream signal will be diluted, until it can no longer sustain further proliferation beyond a given primordium size. The proposed research and training programme will focus on three scientific objectives. Firstly, we will test the above model by analyzing in detail the range and dynamics of KLU signalling in growing organs. This will be done using a specific KLU-responsive reporter gene based on the analysis of identified KLU-responsive promoters. Secondly, we will determine whether KLU only acts locally in growing organs or whether its range of action is long enough to be able to coordinate growth throughout the shoot. ‘Genetic grafting’ to combine varying proportions of klu mutant and wild-type tissue in one plant will be used to answer this question. Thirdly, we will screen for mutants in additional genes required to generate, perceive and transduce the KLU-dependent growth signal, using a luciferase-based reporter system. These complementary approaches will provide important insight into the dynamics and molecular mechanism of KLU-dependent signalling in size control. Conceptual
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CONTROLLING - SYSTEMS FOR HOSPITALS' (COST).

assistant: **Concept**

The project concerns a Controlling and Management Information System for hospitals which would provide decision-making related to financial stability and efficiency. The system will be applicable European-wide and is based on the activity-oriented high tech RICHE/NUCLEUS project as well as on the European computing standards developed. The result will be a very efficient set of control tools.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Functional Coding of Neuropeptide Signaling Networks in Learning' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Humanity has always been intrigued by the brain’s ceaseless capacity to learn and store experiences. However, the ability to acquire and retrieve learned information is dynamic and regulated by a bewildering variety of chemical messengers. Neuropeptides form the largest and most diverse group of neuromodulators and play important roles in learning. Growing evidence exists showing that they form dense signaling networks, with most neurons expressing many neuropeptides and receptors, but how this complex network is engaged in learning circuits has not been systematically explored in living animals. Our working hypothesis is that the concerted actions and integration of neuropeptide signals mediates flexible control of learning circuits.We will test this hypothesis in the small and well-described nervous system of C. elegans, building on system-wide peptide network maps recently generated by my group. Given their high diversity, such a controlled context for penetrating the complex neuropeptide “language” in learning circuits is preferable. We will first identify the molecular pathways by which C. elegans neuropeptide GPCRs modulate neural activity, as this will provide the foundation to dissect their concerted actions. We will then systematically test how neuropeptide pathways impact short-term aversive learning in defined gustatory and olfactory circuits, study their impact on whole-circuit activity, and determine their temporal dynamics. Pertinent questions we will address include: ‘What are the unique versus redundant effects of neuropeptides in a learning context?’; ‘How do cellular networks encoding aversive experience respond to and integrate neuropeptidergic network activity?’ and ‘When do neuropeptidergic networks act to potentiate or attenuate learned responses?’
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Triboelectric Nanogenerators Printed from Composite Inks for Energy Harvesting'.

assistant: **Objectives**

Triboelectric nanogenerators have recently emerged as a very promising energy harvesting technique for transforming mechanical energy into electrical energy. Their emergence is especially timely as the world undergoes a sustainable energy revolution and these devices have successfully demonstrated energy harvesting from a vast range of applications from wind to wave to wearable textiles. Importantly, they can also be fabricated from common materials such as paper, polymers, and graphite. However, as most highly triboelectric materials are polymeric, they suffer from low currents and brittleness under friction, with high performances usually only achieved using complex materials with a large number of processing stages. These are major challenges that are preventing the widespread and long-term application of these devices. This project will simultaneously address all of these issues by developing a printable polymeric composite containing 1D carbon nanotubes (to improve both mechanical strength & electrical conduction) and 2D nanosheets of molybdenum disulphide (to improve the charge retention & operation lifetime) which, in combination with a paper-based tribopositive layer, will form the basis of a low-cost, high performance & robust triboelectric nanogenerator. Crucially, as this composite will be printable it will be compatible with scalable processes such as roll-to-roll or flexographic printing. Success here will be achieved by combining the applicant's expertise on printable nanomaterials with the supervisor's knowledge and background on triboelectric generation and energy-storage devices. We will also demonstrate the practical utility of these devices by printing a device capable of harvesting energy from a bicycle tyre under cycling conditions. The creation of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Polarizing Chats? Political Misinformation on Discussion Apps in India and Brazil.' (POLARCHATS).

assistant: **Concept**

In many developing countries, political actors make extensive use of discussion apps such as WhatsApp to diffuse misinformation. This political use of discussion apps has been hypothesized to generate hatred towards targeted social groups, support non-democratic tactics and values, and eventually lead to the election of politicians who rely on this tactic. In spite of alarming reports, little systematic knowledge exists about political actors’ reliance on discussion apps or about its effects. Since 2016, social media misinformation has provoked considerable attention in academia. This literature has however almost entirely overlooked discussion apps. This lack of scholarship is puzzling, insofar as discussion apps may constitute a greater menace than other services. Two distinctive technical features of WhatsApp – encryption and the necessary existence of pre-existing ties between group members – arguably make these apps efficient vehicle for political misinformation. Drawing on this intuition, I hypothesize that WhatsApp constitutes a preferential channel for the circulation of political misinformation; that features of WhatsApp communities make it more likely than misinformation will be believed, less likely that it will be corrected, and more likely that it will have an impact on users’ downstream attitudes. The project relies on qualitative and experimental methods to test hypotheses derived from this intuition in two large democracies in which political actors are widely hypothesized to use WhatsApp: India and Brazil. Relying on in-depth interviews, the project examines how and why party actors embrace the technology. Second, it relies on crowdsourcing to quantify misinformation on WhatsApp. Third, the project develops two types of experimental designs to examine t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Using PML nuclear body biology to identify potential AML treatment targets' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Understanding the initiation and development of acute myeloid leukemia (AML) represents an important challenge which may lead to the identification of new therapeutic strategies. Acute promyelocytic leukemia (APL) was formerly the most lethal subset of AML; however, today the vast majority of APL patients can be cured by combination therapy. Therefore, fully understanding the mechanisms underlying successful treatment, by analysing the biology of APL pathogenesis will assuredly improve the management of AML subsets associated with a poor outcome, such as NPM1-mutated AML. Using a novel knock-in mouse model, PmlC62A/C65A, which mimics Pml nuclear body (NB) disruption induced by the main oncoprotein PML-RARα in APL, we have previously shown that Pml NBs are essential in APL pathogenesis and treatment response. Our project “PMLingAML” aims to carry on elucidating the impact of Pml NB disruption in APL, and then to apply this knowledge in other AML subsets. To this end, a mass spectrometry analysis will be conducted on both hematopoietic stem and progenitor (LSK) cells and promyelocytes isolated from healthy and leukemic murine bone marrows, to decipher the consequences of Pml NB disruption on the SUMOylome. Next, since PML NBs and NPM1 share common cellular functions and characteristics, we will analyse the inter-relationship between them; their localisation and dynamics will be assessed according to their respective status (disruption, mutation, knock-out), for example by high resolution imaging, both in various healthy and leukemic mouse models (incl NPM1c+ and NPM1c+/FLT3ITD), and in patient samples. Their respective roles in response to a drug under clinical trial, Dactinomycin, will also be scrutinised. Finally, as DNA damage repair is an important function disrupted
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Flexible laser-assisted micro-engineering (FLAME)' under Fifth Framework.

assistant: **Concept**

The growing marked of micro-system technology (MST) shows an increasing need for alterative manufacturing methods which can be applied to a larger variety of materials and geometry than is possible today. Laser micro- structure manufacture relies on direct ablation, a process whereby the short pulse of a laser remove a thin layer of material. The processes of drilling, cutting and 3-D micro-structuring can be realised by placing a huge number of single, laser induced micro-ablations. The aim of this project is the development of a novel, compact, laser based machine tool with an extreme high flexibility concerning the variety of materials and geometry, reached by the different laser types and the realisation of a flexible strategy. This type of machine will allow the economic manufacturing of prototypes and small batch sizes of high precision micro components. The efficiency of the novel machine and the developed strategies will be proved by the manufacturing of demonstrator devices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'A GLOBAL THEORY OF REFLEXIVE DEBT (DELIBERATION)' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Modern capitalism is essentially built on the institution of debt. The unlimited conception of debt reinforces an infinite growth logic and drives economic, political, cultural and ecological unsustainability. A crucial research question is how to constitute debt as more sustainable socio-economic medium. The RESOLVENCY project aims to shape a new (socially) reflexive debt paradigm by rethinking insolvency law as reflexive (democratic) debt deliberation. The project intends to set up a global theory of debt deliberation (for firms, consumers and states), which outlines a new RESOLVENCY paradigm for insolvency law reintegrating over-burdened debtors into the economic system (making them re-solvent) and incorporating other social (political, cultural, ecological) perspectives. Resolving debt conflicts requires a collective procedure including debtor, creditors and all other private (employees, inhabitants) and public (communities, environment) interests involved.  Advancing PIs novel discursive normative grammar (DNG) methodology and combining it with empirical methods, the project has four main objectives: (A) to reconstruct a universal argumentative frame (an insolvency DNG) for debt deliberation integrating normative principles (values) from corporate, consumer and sovereign insolvency theories across different jurisdictions; (B) to newly classify insolvency laws worldwide with a global comparative insolvency law theory based on this DNG; (C) to model and experiment with legal designs of reflexive debt deliberation procedures (RESOLVENCY law); and (D) to outline a model of reflexive debt (RE:DEBT) and analyse its ex ante effects on credit markets. The project does not only impact any legal and economic research on insolvency, but also debt theory in all social and sust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Understanding how self-movement representations shape motor learning' (FlyLearn) under Horizon 2020.

assistant: **Objectives**

To execute accurate movements animals must continuously calibrate their behavior to changes in their bodies and the environment. This process, called sensorimotor adaption, is thought to take place by comparing sensory feedback with internal movement representations. How the brain compares sensory information to movements and updates behavior is not well understood for any animal species. We propose to tackle this problem by using the fruit fly, because, flies have a set of neurons (HS cells) that integrate movement with visual information, being ideal candidates to convey information of self-movement during learning. Also, in a wide array of species spanning from the C. elegans to mice, including the fruit fly, when animals transition to low locomotion states serotonergic neurons are active, being possible substrates to calibrate movements to visual feedback. Here, we propose a set of experiments to inhibit and activate HS cells and serotonergic neurons and casually link their activity to sensorimotor adaption. Also, we will record the neural activity from these neurons to understand how the neural signals in HS cells and serotonergic neurons change during motor learning. This project will provide a detailed mechanistic description on how representations of self-movement in the brain are modulated by serotonin and used for motor learning. This knowledge will be useful to inspire new motor learning theories and understand how the brain generates behavior.


**Keywords:** Motor learning, sensorimotor integration, serotonin, HS cells, optic flow, Drosophila melanogaster, optogenetic activation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Safe Nano Worker Exposure Scenarios'.

assistant: **Concept**

The main goal of Sanowork project is to identify a safe occupational exposure scenario by exposureassessment in real conditions and at all stages of nanomaterials (NM) production, use and disposal.In order to address this and more specifically the issues introduced by NMP.2011.1.3-2 call, we intend to:1. contain hazard and worker exposure potential by developing exposure mitigation strategy based on‘‘Prevention through Design’’ approach.2. implement a rigorous exposure assessment in the workplace in order to evaluate the effectiveness of existing and proposed exposure reduction strategies.3. perform risk analysis off  line and on site in order to identify substance product properties and operational condition that ensure a safer worker exposure scenario.4. Assess COST/ EFFICIENCY of the proposed strategies on the basis of  risk analysis results,  materials/properties efficiency, risk transfer to insurance underwriter community.The Sanowork proposed risk remediation strategy will be applied to nanomaterial properties. The following“representative” pool of NM and nanoproducts have been selected: TiO2 and Ag (ceramic or textilephotocatalytic/antibacterial surfaces); CNTs (polymeric nanocomposites); organic/inorganic nanofibers(nanostructured membranes for water depuration system). The strategy is addressed to mitigate risk bydecreasing adverse health hazard and emission potential of nanomaterials, setting back processes of transportto the point of entry.A sound balance between exposure and health hazards data, before and after the introduction of existing andproposed risk remediation strategies, will allow to evaluate the effectiveness of existing and proposed exposure reduction strategies. The cooperation with industrial key partners such as Plasmachem, Elmarco,  GEA Niro