RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Pre-CommerciAl ProCuremenT of Innovative Personal ProtectiVe Equipment for First REsponders', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The ACTIVE PCP project addresses critical shortcomings in Personal Protective Equipment (PPE) for first responders, aiming to enhance their safety, operational efficiency, and adaptability in the face of evolving threats, including Chemical, Biological, Radiological, Nuclear, and Explosive (CBRN-E) incidents. The project leverages the Pre-Commercial Procurement (PCP) approach to drive innovation in PPE, focusing on multi-hazard scenarios and integrating advanced features such as lightweight materials, ergonomic designs, health monitoring sensors, and GPS tracking systems.Key objectives include: (a) developing harmonised technical specifications through extensive stakeholder consultations; (b) encouraging supplier participation across Europe via open market consultations and matchmaking activities; (c) advancing innovative PPE prototypes through phased R&D, including design, prototyping, and pilot testing in real-life emergency scenarios across various EU Member States.The ACTIVE PCP initiative also emphasises compliance with EU safety and procurement standards, ensuring interoperability and cross-border applicability. The project fosters collaboration between public procurers, suppliers, and researchers, creating a robust ecosystem for innovation. Planned dissemination activities, such as workshops, training sessions, and publications, aim to maximise awareness and adoption of the project outcomes.Expected impacts include improved PPE usability and reliability, reduced costs through reusable and scalable designs, and enhanced responder preparedness and effectiveness in high-risk situations. Additionally, the project will strengthen the European industrial base by validating and commercialising advanced technologies, ultimately boosting EU resilience to large-scale emerg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Signalling mechanisms in human embryonic stem cells'.

assistant: **Innovation**

Human embryonic stem cells (hESCs) have the potential to proliferate indefinitely when maintained undifferentiated in culture, and to differentiate to basically all functional cell types. The molecular mechanisms underlying these biological processes in hE SCs are not well characterized. To maintain these cells undifferentiated in culture they can be cultured on an extra-cellular matrix in the presence of conditioned medium from mouse embryo fibroblasts (MEFs) and fibroblast growth factor-2 (FGF-2). This sugg ests that MEFs produce a factor/s that is/are required for the maintenance of undifferentiated state of hESCs. Further analysis has revealed that treatment of the MEFs with FGF-2 is involved in the production of these factors. A global expression profile analysis using micro-arrays between MEFs treated without or with FGF-2 indicated that around 20 secreted factors are down regulated in the absence of FGF-2. These factors included several ligands for known signaling pathways as well as extra-celluar proteases, which in turn can be involved in the processing of ligands, and components of the extra-cellular matrix, which in turn can be involved in cells matrix interaction and subsequent signalling events. The identification of these factors and the availability of ESTs harbouring their genes will allow us to identify factors required for the undifferentiated state of hESCs and their downstream signalling events. Moreover we have recently shown, that activation of the Activin/Nodal signalling pathway and subsequent activation of the transcription factors Smad2/3 are important for the maintenance of the undifferentiated state. The interaction of the regulation of the Activin/Nodal pathway and the factors secreted by the MEFs upon FGF-2 treatment will reveal important m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Heart regeneration in the Mexican cavefish: The difference between healing and scarring', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Whereas the human heart cannot regenerate cardiac muscle after myocardial infarction, certain fish efficiently repair their hearts. Astyanax mexicanus, a close relative of the zebrafish, is a single fish species comprising cave-dwelling and surface river populations. Remarkably, while surface fish regenerate their heart after injury, cavefish cannot and form a permanent fibrotic scar, similar to the human heart. Using transcriptomics analysis and immunohistochemistry, we have identified key differences in the scarring and inflammatory response between the surface and cavefish heart after injury. These differences include extracellular matrix (ECM) proteins, growth factors and macrophage populations present in one, but not the other population, suggesting properties unique to the surface fish scar that promote heart regeneration. The objective of the proposed project is to characterise and utilise these findings to identify therapeutic targets to heal the human heart after myocardial infarction. First, we will analyse the identified differences in scarring and immune response between the fish in detail, before testing the role of the most interesting proteins and macrophage populations during regeneration using CRISPR mutagenesis and clodronate liposomes. Next, we will link the key scarring and inflammatory differences directly to both the genome and the ability for heart regeneration using new and prior Quantitative Trait Loci analyses. This will allow to find the most fundamental molecular mechanisms directing the wound healing process towards regeneration versus scarring. Together with an in vitro and in vivo small molecule screen directed specifically at influencing scarring towards a more ‘fish-like’ regenerative phenotype in the cavefish and mouse heart after injur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Sustainable energy technology at work on the market generated by the EU emission trade scheme and the linked CDM and JI markets' (2002-2006).

assistant: **Concept**

The overall objective of the T@W proposal is to undertake thematic promotion of RES-e, RES heating and cooling and Poly-generation (Sustainable Energy Technologies, SET) at emerging Emission Trading Scheme (ETS) markets in EU and CDM markets in Asia. The T@W action is highly relevant with the aim of exploiting FP RTD results at these markets, thereby bringing SET to the market. Hence; the short title: Technology at Work.The T@W actions entail 5 work packages: WP1 T@W Co-ordination: Entails project co-ordination in line with the FP6 procedures. WP2 SET Promotion at EU ETS market: Comprises a thematic approach to promotion of SET at ETS companies operating on the ETS. The activities will address RTD aspects, project facilitation and business concept aspects of the emerging market. WP3 SET Promotion at CDM markets: Entails a parallel thematic approach to promotion of SET at the CDM markets under rapid development in Asia. It will address the same themes as under WP2.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Integrating European Timing Analysis Technology'.

assistant: **Objectives**

A large class of embedded systems has safety, availability, reliability, timing and performance requirements. Timing analysis is needed in many steps of the development process; it is a key to rapid designing and prototyping of embedded systems, to reduce system overall cost through efficient resource management (especially: tradeoffs when co-developing hardware and software), to find bottlenecks in the software, and to validate that the system meets its timing requirements. There is a growing awareness of the importance of correct timing for these systems, however, there is still a lack of efficient methods and tools for timing assessment and validation that can be used in European industry. The existing timing analysis technology by far does not exploit the potential inherent in European research results and timing tools.<br/>The ALL-TIMES project aims at combining and developing research results and timing tools currently available and thus to strengthen the European lead in the timing analysis area. The ALL-TIMES project will enable interoperability of tools from SMEs and universities, and develop integrated tool chains using open tool frameworks and interfaces. By combining research results and commercial tools, ALL-TIMES will ensure the flow of ideas from basic research to practice.<br/>ALL-TIMES will strengthen the competitiveness of several key industries in Europe, not only the automotive and aerospace areas (where partial awareness already exists) but also automation, manufacturing, robotics, medical, communication, and multimedia, and other market areas where timing is of importance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Assessment of the threat of metal exposure to lions (Panthera leo) in East Africa' (LEOTHREAT).

assistant: **Innovation**

The lion population of East Africa is declining due to several reasons, and pollution listed as one of the current threats by IUCN. However, no data on exposure routes of pollution from mining on lions in East Africa are available and metal pollution in terrestrial ecosystems in East Africa is understudied. The current proposal aims to fill this gap by looking at both metal exposure in lions and their main prey close to mining areas and in reference areas away from suspected pollution. In addition, non-invasive sampling of fur will be assessed as biomonitoring tool for metal exposure. Finally, we will provide recommendations to local authorities and communicate our findings to local communities. This project will give me the opportunity to apply my previous knowledge on metal pollution in wildlife and to gain new expertise working in African ecosystems and with African communities, as well as gain new practical skills, such as sampling large carnivores. Furthermore, my supervisors at the Norwegian University of Science in Technology (NTNU) provide interdisciplinary expertise within ecotoxicology (Prof. Jaspers) and conservation ecology (Prof. Røskaft).LEOTHREAT’s main research question is: What are the main exposure routes for metals in East African lion populations? I hypothesize that lions inhabiting mining sites may be exposed to metals due to the ingestion of contaminated prey and water. The exposure to toxic metals may cause adverse effects on their health, thus contributing to population declines. Me and local collaborators will study metal exposure by sampling blood and fur from lions inhabiting areas close to mines as well as from lions ranging areas unsuspected to be contaminated.


**Keywords:** Lions, metals, ecotoxicology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Functional and neuronal underpinnings of synchronization to auditory stimuli'.

assistant: **Innovation**

The ability to synchronize with auditory stimuli is ubiquitous. This can be observed, for instance, when people listening to music move in synchrony with its beat. Results obtained with healthy individuals and brain-damaged patients support the idea that synchronization is a fundamental process, which is very likely rooted into human biology.Synchronization has often been assessed by asking subjects to tap their finger in synchrony with auditory stimuli, such as a sequence of tones equally spaced in time (tapping task). The functional mechanisms underlying synchronization in the tapping task have been described quite thoroughly (e.g. see stochastic mathematical models). However, evidence about the neuronal underpinnings of such processes (e.g. the basal ganglia and the cerebellum) is still unclear.Moreover, it is still unknown whether the processes underlying synchronization are domain-specific (e.g. for music) or, instead, general-purpose mechanisms. The main goal of the present study is to shed light on t he processes underlying synchronization to auditory stimuli (i.e. non-musical sequences vs. music) and on their neuronal underpinnings.In particular, the contribution of the basal ganglia to auditory synchronization will be examined. To this aim, performance in tapping tasks will be assessed pre- and post-operation in patients suffering from intractable Parkinson's disease undergoing therapeutic surgical treatment (i.e. pallidotomy) and in two control groups (i.e. patients with Parkinson's disease who will not undergo surgical treatment and normal individuals).The results of the planned research have the potential to significantly increase our knowledge of the biological foundations of synchronization. In addition, since synchronization has revealed as an efficient t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding forest growth dynamics using novel 3D measurements and modelling approaches' (3D-FOGROD).

assistant: **Concept**

Forest ecosystems are an essential terrestrial carbon sink, and deforestation and forest degradation account for about 12% of global anthropogenic carbon emissions. However, estimates of the global distribution of terrestrial carbon sinks and sources are highly uncertain. Constraining the inaccuracy of carbon estimates is essential to support effective forest management and future climate mitigation. A better understanding of forest growth dynamics will improve our understanding of the carbon cycle and mechanisms responsible for terrestrial carbon sources and sinks, reducing uncertainties on their magnitude and distribution.  In the 3D-FOGROD project, I aim to improve our understanding of forest growth dynamics and evaluate the role of elevated CO2 levels on forest growth. I will achieve this by using novel 3D laser scanning (LiDAR) techniques, unique datasets and state-of-the-art modelling approaches to (1) accurately quantify forest growth using terrestrial LiDAR data in a free-air CO2 enrichment experiment; (2) improve historical and future simulated forest growth dynamics using LiDAR derived forest structure for a range of forest ecosystems; and (3) develop and disseminate recommendations for climate mitigation actions to policy makers based on new insights in forest growth dynamics and carbon cycling.  The proposed scientific innovation and applicability will benefit the EU not only by generating new knowledge and publications in high-profile scientific journals, which will contribute to the enhancement of EU scientific excellence, but also by contributing to EU commitments to the Paris climate conference (COP 21) agreement that aims to limit the increase in global temperature to 1.5°C. The science excellence and training through 3D-FOGROD will enable me to apply f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dynamics and statics of glasses and spin glasses: from aging to memory and equilibrium structures.' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Our approach uses numerous techniques, so that the young scientists will be trained in many fields: we will push them to move readily between pure theory (concepts, mathematics), simulations (hands-on-experience on large, small, and special-purpose computers) and experiments (real experiments or fruitful dialogue with experimentalists), all in the context of one of the most dynamic fields of condensed matter. The training will be concentrated on the fundamental physical aspects, where the partners excel. However, this field has a huge potential for industrial applications including ceramics, opto-electronics, bio- and other soft materials. Within our groups we have ample contacts with industry and they will be used to improve the training. Workshops, schools and topical meetings will be crucial. Our young scientists will spend part of their time in two or more nodes to become familiar with a large variety of techniques.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Experimental Radiotherapy for Malignant Brain Tumours', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The aim of my project is to test two novel experimental radiotherapies which potentially can improve the quality life in patients with malignant brain tumours or with multiple brain metastases. Both methods are being developed at international synchrotron facilities. One of the techniques, microbeam radiation therapy (MRT), is already being studied by several groups and my work is focused on the assessment of adverse effects like memory deficits and bystander effects. Concept and equipment for the second technique, pencilbeam radiotherapy, have only recently been developed at the ESRF in France. Our team will be the first to obtain biological data and assist in developing the technique to a point where a valid assessment can be made regarding its feasibility for therapeutic approach in human patients. All tests will be conducted in well-validated small animal models for an advanced, highly malignant primary brain tumour and for multiple brain metastases from a mamma carcinoma.We will study the acute effects of the radiotherapy in short-term experiments as well as generate survival curves and behavioural data in long-term survivors. In order to document the efficacy of the experimental therapy we will also use a high-resolution synchrotron-based X-ray imaging technique, in which small groups of cells loaded with an X-ray opaque marker can be detected. The applicant for this project is one of the four patent holders for this method.The Marie Curie Reintegration Grant would help me to establish my own work group in Freiburg, thereby combining my previous research experience with the interests of the Department of Stereotactic Neurosurgery and the Laboratory of Molecular Neurosurgery, where I have been working since September 2009. The project also integrates research facil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Strain Monitoring in Composite Stiffened Panels Using Sensors' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

STRAINMON aims to develop and establish a methodology for the strain monitoring of composite fuselage stiffened panels using embedded and/or bonded Fiber-Optic Bragg Grating (FOBG) sensors and strain gauges. The proposed work-programme of STRAINMON is summarized as follows:1. Definition of the FOBG system requirements and specifications based on the nature of the problem and the available technology using progressive damage modeling. The number of sensors will be decided and the network of sensors will be designed.2. Description of the methodology for integration of sensors related to the autoclave manufacturing process by ensuring measurement capability of the sensors, integrity of sensors, and integrity of the parent composite material.3. Design of the test plan and design and fabrication of the test-rig,4. Execution of the series of the following tests to establish the proposed SHM methodology:-Compression tests to failure on undamaged panels to characterize their reference compressive behavior,-Low velocity impact tests on selected critical locations of the panel in order to create impact damage,-Compression tests to failure on the impact-damaged panels to evaluate the residual stiffness and strength of the panels,-Fatigue of impact-damage panels up to a certain number of cycles in order to create additional fatigue damage,-Compression tests to failure of panels subjected to impact and fatigue to evaluate the residual stiffness and strength data of the impacted and fatigued panels.After each test series, NDT inspection of the panels will be conducted in order to detect the type, extent and location of damage induced.Each of the above tasks meet an activity of the topic.A reliable and effective data acquisition system will be build to take sensor measurements at appr