RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Networks of Centres of Expertise for CF (Cystic Fibrosis), LAM (Lymphangioleiomyomatosis), and LTX (Lung Transplantation)' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

European Centres of Expertise Networks for rare diseases have been identified by the European Commission as one important area of future activity in the attempt of achieving one of the main objectives across the EC endeavour of “Optimising the delivery of health care to European Citizens”. It is obvious that especially in rare diseases the joined forces of the experts networking throughout Europe are more likely than national services to meet the needs and expectations of patients. The construction and implementation of European networks of centres of expertise (ENCE) call for input from many different stakeholders: patients and doctors and other care team members, clinical researchers, health administration, and health insurers will have to be heard to come to a model of such networks that can easily be used as blueprint for most of the rare disorders.  To achieve this goal first a mapping exercise of existing networks and elements needed for such networking has to be done. We plan to do so for three different rare entities, i.e. cystic fibrosis (CF), pulmonary lymphangioleiomyomatosis (LAM), and lung transplantation (LTX), having in common that they all comply with the EC definition of a rare disease. From the information gathered during this process the areas of activity and a detailed set of criteria for such European networks will be developed. These construction principles will be brought together in a blueprint to be used for other rare disorders. These criteria can then be used for certification, quality control, and funding of a European system of networks. Networking in this European sense will make the best possible use of  resources already existing and remaining in the responsibility of the individual member states by interfacing and complementing these pre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hibernation timing to reveal mechanisms of rheostasis' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

HiTime is a project about the adjustment of homeostatic set points in physiology. This is known as rheostasis and is of core importance for transitions between physiological states. I seek to develop the concept that a specialised cell type in the hypothalamus, the tanycyte, is the cellular embodiment of a rheostat, and that by understanding the function of the tanycyte, we will gain fundamental insights into hypothalamic control of rheostasis. Since rheostasis is weak in laboratory mice bred to live in constant laboratory environments, new paradigms must be developed. I will therefore investigate tanycyte function in the context of seasonal deep hibernation: the most dramatic example of rheostatic control of energy metabolism in mammals. I will use the golden hamster as the study organism because it has an excellent combination of attributes for pursuing the project aims, from experimental tractability to availability of molecular resources. The study approach will exploit advanced telemetry combined with transcriptomics, metabolomics and neuroimaging to develop an unprecedented “arrow of time” description of changes in tanycyte status in relation to peripheral and central changes in energy metabolites throughout the hibernation. This approach will encompass both long-term rheostatic control of seasonal entry and exit from hibernation, and short-term rheostatic control of torpor-arousal cycles during the hibernation phase. In parallel, I will develop neurogenetic and micro-infusion approaches to allow characterisation of the causal events in rheostatic hibernation control. My career track record gives me an unusual combination of in vivo physiology and bioinformatics skills, which, in combination with my pilot studies establishing new techniques, gives an excellent cha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Genetic encoding and click chemistry with copper-chelating azides for super-resolution imaging of proteins' (GECCCCA) targeting Seventh Framework.

assistant: **Abstract**

Super-resolution biological microscopy would benefit from a much smaller alternative to green fluorescent protein and enzyme-mediated labelling methods for imaging specific proteins in cells. To facilitate routine tagging of organic fluorophores to cellular proteins for super-resolution imaging, we aim to combine genetic code expansion (the most non-invasive tagging method) with cell-compatible CuAAC with copper-chelating azides (the fastest bio-orthogonal reaction) and extend the utilities of the method to labelling of specific proteins in different subcellular locales, including intracellular.The proposed work here is highly interdisciplinary, combining techniques from synthetic organic chemistry, in vitro evolution of novel protein function, optimizations of protein and chemical functions in mammalian cell context, and super-resolution protein imaging. The work is designed to take advantage of the fellow’s experience in protein labelling, bio-orthogonal chemistry and super-resolution imaging, along with the European host’s proficiency in in vitro evolution and genetic code expansion. The goal is to maximise the mutual transfer of knowledge while obtaining new methodologies and molecular insight into biological systems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Smart integRation Of local energy sources and innovative storage for flexiBle, secure and cost-efficIent eNergy Supply ON industrialized islands' (ROBINSON), addressing dissemination and exploitation.

assistant: **Impact**

ROBINSON will optimise the utilisation of local renewable resources by deploying an integrated, smart and cost-efficient energy system coupling thermal and electrical networks, demonstrated in industrial environment on the Eigerøy island, Norway. It will integrate i) commercially available technologies and storage, ii) novel technologies adapted and developed in ROBINSON, such as a micro gas turbine based Combined Heat and Power unit running on a mixture of local renewable fuels, an Anaerobic Digestion system assisted by a biolectrochemical process producing bio-methane from wastewater, and an innovative wind turbine, as well as iii) industrial symbiosis concepts, such as waste, heat and oxygen valorization. An optimized intelligent Energy Management System (EMS) with advanced control system considering weather forecast, market fluctuations and demand response, will ensure the grid stability, power balance and security of supply. The ambition of ROBINSON is to decrease the energy production costs, reduce dependence on mainland power and phase out fossil fuels currently used by the demo island’s industries in a relatively short term, thus significantly contribute to island’s decarbonization. The user-friendliness and high modularity of the developed EMS then ensures a great potential for replication on the Follower islands (Western Isle of Scotland and Crete), but also in other remote areas in Europe and beyond. The project will encourage business opportunities for local communities and, by creating new value chains, open up markets for the developed technologies having a positive impact on EU’s competitiveness in low carbon economy. The Consortium gathers local stakeholders from three islands, technology providers incl. SMEs, Universities and RTOs as well as experts on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Central Nervous System Imaging' (CSI).

assistant: **Concept**

Diseases affecting the brain and the central nervous system are among those with the greatest impact on our society. The ENIAC JU project CSI aims to advance the state of the art in three-dimensional (3D) medical-imaging platforms to improve the efficiency of the diagnosis and therapy of these serious diseases. The objective of the project is to develop an innovative yet simple and low-cost smart 3D imaging system suitable for use in ambulatory or domestic settings, able to enhance early diagnostic accuracy and boost the prevention capability while reducing the total cost of the equipment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metabolomics and contest behaviour in parasitoid wasps' (2007-2013).

assistant: **Concept**

Animal contests are widely studied by animal behaviourists and behavioural ecologists and there is a well developed framework for evaluating their functional significance. Parasitoid wasps in the family Bethylidae have proven ideal organisms to test predictive models (all of the predicted major influences on contest outcome-fighting ability, prior ownership and the way that individuals value possession of the contested resource - have now been successfully explored) and also in linking contests to other areas of basic (e.g. clutch size) and applied (e.g. biological pest control) areas of animal behaviour study.The link between nutritional/physiological state and contest behaviour has rarely been fully explored. The purpose of this proposal is to evaluate a range of nutrients derived from diverse food sources (nectar and the parasitoid’s host) and their influences on contest behaviours andoutcomes. It is expected that particular nutrients may affect contest ability (termed Resource Holding Potential) whereas others may influence the value of the resource to a contestant. The relative importance, and interactions between these contrasting effects, will be explored.Identification and manipulation of key nutrients (proteins, lipids, carbohydrates and other metabolites) will be achieved by metabolomic analysis and other analytical and biochemical methods. The influence of nutritional state on contest behaviour will be assessed by behavioralobservations. The cost of fighting behavior as influenced by nutritional state will be evaluated by real–time respirometry. The interdisciplinary approach of the proposed project will provide training opportunities in a range of modern techniques new to the researcher (metabolomics, NMRspectroscopy, biochemical methods) whereas will provid
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Mechanically-Interlocked Ring-on-Thread Molecules for Super-Resolution Imaging' under Horizon 2020.

assistant: **Concept**

This interdisciplinary project focuses on the development of unprecedented autonomous novel photoactive nanoscopic molecular machines that “blink” for fluorescence microscopy imaging with a resolution higher than the light scattering limit. Its use in super-resolution imaging will represent a major innovation in imaging, both conceptually and practically, overcoming many inherent constraints associated with current techniques. By applying steady-state and time-resolved spectroscopies, photo-induced electron transfer will be used in these autonomous [2]rotaxanes to modulate fluorescence, and studies down to the single-molecule level (based on Stochastic Optical Reconstruction Microscopy) will be undertaken to achieve a new localization microscopy method (""Ring-STORM"") adapted for living cells, without the need for overexpressing genetically encoded fluorescent proteins.The project will be developed at leading French research institutes, Institut des Sciences Moléculaires (ISM) and Institut d'Optique (LP2N-IOGS) both at the CNRS/Univ. Bordeaux. The fellow, a specialist in synthetic organic and supramolecular chemistry from Spain, will receive via the project training in molecular photochemistry/photophysics and super-resolution fluorescence imaging, providing him the necessary skills to design, develop and study novel tailored-made functional supramolecular architectures with enhanced spectroscopic properties. For this, the project is organized in synergistic work packages to assure efficient coordination and management, career development and training, science development, communication and technology transfer by patenting the new super-resolution imaging methodology that Ring-STORM expects to develop. This will give him independence and professional maturity towards a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Scale-resolving Simulations ​for Innovations in Turbomachinery Design'.

assistant: **Concept**

Sci-Fi-Turbo aims to revolutionise the aero engine design process by advancing and integrating high-order scale-resolving simulations (SRS) and optimization methodologies into standard industrial workflows. SRS are a key enabler for developing ultra-efficient propulsion systems that drastically reduce GHG emissions by 2035 and achieve the EU's target to be climate-neutral by 2050. The advancements will boost design process capabilities and reduce product development cycles.  Future engine concepts require opening up the design space and solving complex design problems out of reach for today's standard industrial design processes within the required timeframe. To achieve the necessary step change in engine design, a similar step change is needed for the design approach. Sci-Fi-Turbo fills this urgent need by exploiting opportunities in three foundation technologies: High-performance computing, high-order numerical methods, and AI/ML. The combination is used to implement and demonstrate two key advancements. First, a highly integrated high-order SRS design process is established for modern CPU/GPU hardware, meeting robustness, accuracy, and turnaround time requirements. It will provide increased functionality and effectivity at an industrial level and pave the way for the uptake of SRS-based design by the industry. The high accuracy of the methodology will also reduce the need for low-TRL testing and enable new concepts and extended operating conditions. Second, an SRS-assisted multi-fidelity, data-driven optimisation framework is developed, which embeds and exploits the advantages of highly accurate high-order SRS while leveraging AI/ML methods to increase the predictive capability of lower-fidelity simulations and maximize overall process accuracy and speed. Dedicated e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Converse in AThens 2004, Cologne and Helsinki'.

assistant: **Concept**

CATCH-2004 will develop a multilingual, conversational system with a novel unifying architecture across devices and services. The system will provide pervasive access to multiple applications and sources of information available to citizens from public and private service providers by supporting multiple client devices, and by using multiple input modalities. Client devices are kiosks, telephones (standard and wireless) and smart wireless devices. Applications include access to information over the Internet, travel and city information/services, phone-directories and completion of transactions. A key aspect is to enable multilingual spoken access to information on the web using any of the above listed devices. The presentation of information to the user will be done according to the limitations of the client device. Kiosk access will support both conversational natural language and graphical interactions, access over the telephone will allow only for speech or push button input and spoken responses and wireless telephones and smart wireless devices will offer both speech and text based interfaces.Objectives:The main objectives of the project are to:1. Enable Multilingual Conversational Access to Information for Citizens.2. Describe an architecture for service provision unifying access from different client devices.3. Provide multimodal (spoken & written) language support.4. Provide voice-enabled access to the World Wide Web databases connected to this architecture.5. Enable representation and transformation of information available in multiple forms and languages.6. Develop a user-friendly system giving the ability to complete complex tasks to all users, experts and novices.7. Contribute to open interfaces and standards.Work description:The project will first identify t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Modelling constraints on tree range shifts under climate change: regional and local processes' (PHENO-RANGE-EDGE).

assistant: **Innovation**

Global change is affecting the flora at levels from organism to ecosystems. Changes in population dynamics, phenology, and community composition as well as species range are well documented and will alter patterns of biodiversity in this century. Because forests are major sites for carbon storage, ongoing changes have important implications not only for forest products and biodiversity, but also for the global climate itself. Forecasting shifts in tree ranges have become a critical issue in biodiversity conservation and climatology, and calls upon an unresolved, classic question in ecology and biogeography: what factors and processes set limits to species distribution and abundance. Range shifts necessarily will be influenced by dispersal abilities at regional spatial scales, but in the end depend on availability of suitable habitats at local scales. Shifts in distribution can only be predicted accurately in consideration of species adaptation and environmental heterogeneity near the expanding edge of the range.We will employ methods and perspectives from different fields to develop an integrative scaling framework linking ecological biogeography with processes in community ecology, to precisely identify ecological constraints on species distribution. We will adapt the model PHENOFIT to predict the climate-dependent potential ranges of North American trees. We will use novel statistical methods and field experiments to distinguish the roles of dispersal (neutral process) and adaptation (niche process) in local colonization at the expanding edge of the range. Finally, we will use a macro-ecological approach to quantify critical traits favouring colonization success. Such cross-scale, process-based analyses are the only way to accurately forecast shifts in tree distributi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Reliability-oriented Lightweight Optimization Framework for Intelligent Design of Material-structure Integration' (ROFiDMS).

assistant: **Innovation**

This project will develop novel topology optimization (TO) methods for the design of multi-scale lattice structures built using additive manufacturing (AM) from porous materials to achieve multiple performance criteria (e.g. stiffness and strength, mass and safety factors, static and dynamic performance). To this end, an intelligent lightweight design concept which combines a novel non-probabilistic reliability-based topology optimization (RBTO) framework and efficient solution algorithms, will be developed for integrated material-structure design (IMSD). The action will, for the first time, address a number of technical challenges in the integrated RBTO design of multi-scale lattice structures manufactured from porous materials, (e.g. accurate evaluation of the mechanical properties of high-porosity microstructures incorporating uncertainties, dynamic reliability prediction of multi-scale lattice structures, and non-probabilistic reliability-based design strategies). The applicant, working with the team at CU will deliver internationally recognized knowledge and techniques in the research field of IMSD


**Keywords:** Uncertainty, reliability-based topology optimization, integrated material-structure design, non-probabilistic reliability, additive manufacturing