RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Molecular and cellular mechanisms of arterial pathophysiology' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

To determine the molecular mechanisms controlling the expression of vascular endothelial growth factor by hypoxia and other growth factors. To determine what factors induce smooth muscle cell migration in the arterial wall. To examine the overexpression of 15 lipoxygenase, scavenger receptor, LDL receptor and inhibition of mevalonate metabolism in arterial intimal hyperplasia, in the presence and absence of hypercholesterolaemia.Exposure of cultured rabbit vascular smooth muscle cells (VSMC) to hypoxia and multiple protein growth factors including platelet-derived growth factor (PDGF) induces an increase in expression of vascular endothelial growth factor (VEGF), an angiogenic factor and permeability-increasing factor for endothelial cells. It is proposed to extend previous observations by identifying other factors which induce VEGF expression in VSMC, to investigate the molecular mechanisms underlying these events and to identify the putative hypoxia inducible VSMC migration factor(s). Both the collared artery model and human arterial tissue will be used. The spatial and temporal changes in VSMC phenotype and the interaction with hypoxia and hypercholesterolaemia will be studied. An important aim will be to determine the expression in the collared artery of genes involved in cholesterol uptake and metabolism and implicated in atherogenesis in humans, including 15-lipoxygenase (15-LO) the low density lipoprotein (LDL) receptor and the scavenger receptor. The role of the biosynthetic mevalonate pathway in neointimal hyperplasia will be studied by examining the effects of inhibitors of both HMG-CoA reductase and of farnesyl transferase in normal and collared arteries. Interactions between hypoxia and the mevalonate and cholesterol pathways will also be investigated in VSM
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'DANube SEdiment Restoration: towards the deployment and upscaling of sustainable management of the sediments across the Danube catchment basin'.

assistant: **Objectives**

DANSER represents a multidisciplinary holistic and scientific based approach focused on the Danube River basin, a vital yet sensitive ecosystem facing climate change and human impacts. DANSER addresses pressing sediment management needs in the Danube River ecosystem, incorporating cutting-edge technologies and aligning with EU policies and directives. Especially attaining the core guidelines of the Danube Sediments Management Guidance. DANSER delivers a pilot phase and envisages the deployment phase, with a strong emphasis on demonstrating active and passive innovative solutions, such as a) spatio-temporal mapping of natural and anthropogenic fluvial processes, b) sediment transport modelling, (c) sediment dating by radionuclide and radiometric methods, d) historical pollution analysis (e) geophysical survey and 3D historical reconstruction of the demonstration sites, (f) river-groundwater dynamics and pollution transport modelling, (g) river processes forecast simulations based on historical and active processes, (h) sediment budget analysis based on sedimentation measuring stations, UAV and bathymetry surveys, (i) water levels and quality monitoring and analysis j) river-side arm hydrotechnical connectivity interventions, (k) stakeholder-engaged sediment parametric evaluation and co management and (l) Nature based solutions for biodiversity characterization monitoring and improvement. On the soft measures side, DANSER enforces proactively a transnational sediment task force, from cooperating with all related instances, and commits with local communities and citizens engagement, including participatory tools.DANSER seeks to restore sediment balance, improve sediment flow and quality, characterise pollution transport mechanisms and integrate such actions and knowledge w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Interaction of squalene-based anti-cancer and neuroprotective drugs with cell membranes: in silico study'.

assistant: **Innovation**

Squalene is a natural lipid precursor, which plays a crucial role in the  biosynthesis of sterols in the cells . Squalene is 100% biocompatible, not toxic and is able to enter into the cells easily. This makes it very promising for creating highly efficient drugs and drug delivery systems. The so-called squalenoylation technology is based on fusing hydrophobic squalenic acidwith the molecules of water-soluble drugs. Resulting conjugated molecules spontaneously self-assemble into nanoparticles, which deliver the drugs into the target cells efficiently. Currently anticancer (gemcitabine , doxorubicin ), antiviral (dideoxycytidine ) and neuroprotective (adenosine ) drugs were used in this technology with great success. This project is devoted to revealing mechanisms of interaction of novel and highly promising squalene-based anti-cancer and neuroprotective drugs with cell membranes by means of in silico ccomputer simulations. The main goals of the project are the following:1. To reveal how squalene-based drugs incorporate into the cell membranes, interact with membrane components and are released from the membranes on atomistic level of details.2. To propose the ways of improving translocation of squalene-based drugs through the membranes in order to increase their therapeutic efficacy.The practical impact of the project is improving translocation of squalene-based drugs through the membranes and making it selective, which is of great interest for therapeutic applications of existing drugs and for creation of new compounds with desirable properties.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Web technologies for West Balkan countries' (WEB4WEB), addressing dissemination and exploitation.

assistant: **Impact**

The field Semantic Web technologies is one of the fastest developing fields within the IST Thematic Priority, while at the same time this field is almost completely neglected in West Balkan Countries. The main objective of the Web4WeB project is to establish regional Centre of Excellence for Semantic Web technologies within the oldest and the biggest research Institute in ICT area in the whole West Balkan region the Mihailo Pupin Insitute from Belgrade.The mission of the Web4WeB is to raise the awareness and facilitate faster take-up of the Semantic Web and other advanced Web technologies and standards (Web services, Service Oriented Architecture, Web Agents, Web Query languages ) and to increase the level of competence of all the stakeholders in the region (research centres, ICT industry, SMEs, service providers, etc.). Once established, the centre of excellence will promote the added value of the Semantic Web technologies in the increasingly competitive knowledge economy, co-ordinate the research efforts and unite scarce research resources in this field in the whole West Balkan region, but also encourage communication with external parties (especially EU NoEs, like Knowledge Web, REWERSE, etc.).This way, the Web4WeB project will contribute to sustainable research development in the field of Semantic Web technologies in the region, ensuring its better integration into European Research Area. To summarize, the mission of Web4WeB is to strengthen the West Balkan s research body, industry and service providers in one of the most important areas of current computer technology Semantic Web. The centre of excellence that will emerge from the Web4WeB project, will concentrate its efforts around the outreach to West Balkan research body, coordination of research efforts in the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'High-lift devices with variable camber for an adaptive wing' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content Aim of the research project is development and realization of a wing element with variable camber (flap or control surface). Wing structures are actually realized as a system of rigid bodies (main wing, ailerons, flaps, etc.) and the aerodynamic field are influenced by changing relative positions of these parts. If it was possible to variate wing geometry by more than these degrees of freedom, e.g. allowing shapes changes in some wing elements, large advantages will be achieved in controlling aerodynamic field and hence flight dynamics. In the past some investigations in this field were performed, however, none of the proposed solutions was realized in practice. In fact realization of a controlled variable geometry with conventional techniques requires heavy and complex mechanisms. 'Smart structures' strategy open a new perspective for the adaptive wing concept, in fact these new materials make geometric variability feasible without the above mentioned disadvantages. In the proposed research this possibility will be investigated in particular for high-lift device with variable camber. Training content (objective, benefit and expected impact) The objective is the realization of a wing element with variable camber. A qualifying experience in the smart structure field will be the main benefit of the proposed training. Moreover experiencing into following topics is expected: solid state actuators: design, structural integration, experimental properties evaluation; aircraft structures; composite materials. Links with industry / industrial relevance (22) The idea to provide a wing with variable camber is clearly interesting for the aeronautical transports. In fact such a realization could be introduce large advantages concerning manoeuvrability
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Implementation of ACT in Daily Life' (IMPACT) under Horizon 2020.

assistant: **Objectives**

Mental health problems constitute a major individual, family and public health concern, affecting up to 30% of the population. Yet, both pharmacological and psychological interventions only reach modest effect sizes. There is a need for new and better personalised interventions. In my ERC 'INTERACT' project, we adopted a mobile Health (mHealth) approach for the treatment of psychotic disorder. We developed ACT-DL (Acceptance and Commitment in Daily Life), an app that complement face-to-face ACT sessions with ACT exercises in real-life, guiding individuals in the application of ACT in real-time. This mHealth approach a) extends the therapy beyond the clinical setting into real life, b) makes therapy more widely available, and c) provides therapy at specific moments of need. The problem that remains to be addressed in this Proof-of-Concept project is to bring ACT-DL to the clinical market. In IMPACT, we aim to transform the research app into a clinical ACT-DL app that can be implemented in a naturalistic clinical setting. In order to do that, we will: 1) adapt the ACT-DL app according to the feedback of the clinicians so that it reaches the flexibility needed in clinical practice,  2) develop an implementation strategy plan focusing on integration of ACT-DL in the existing health care infrastructure (data safety, data privacy, data integration and long-term sustainability) and on clinical uptake by clinicians, 3) run an implementation pilot to test acceptability, feasibility and generalisability, and 4) develop a business model. The implementation of ACT-DL in the naturalistic clinical setting will have clear societal and economic impact as it will improve the effectivity of treatment while we give patients a tool to help themselves. Furthermore, as very little mHealth ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'European mouse mutant archive resource database' (1994-1998).

assistant: **Innovation**

The European Mouse Mutant Archive (EMMA) has organized a central repository facility and an associated network of European nodes for stocking, preserving and redistributing the mouse mutant strains that are produced by scientists from both European and extra-European countries. An essential objective of the EMMA project is to foster the functional coupling of the EMMA stock centres and related information systems through the establishment and maintenance of a dedicated resource database (EMMA-RDB). This database will classify and describe all the mutant strains which EMMA is stocking and their genetic and phenotypic properties. It will also constitute a fundamental tool for the management of scientific, technical and logistic activities carried out by each EMMA node and for the co-ordination and harmonization of the resources and services to be shared by the different nodes. The project will also implement user-oriented access interfaces which will provide external users with appropriate services for the development and application of protocols and standards facilitating data exchange and the distribution of EMMA scientific and technological resources. This proposal deals with the initial phase of the establishment and publication of the EMMA-RDB, under the co-ordination of the Consiglio Nazionale delle Ricerche EMMA main site (CNR-EMMA) in Monterotondo (I) with the scientific and technical assistance of the European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI; Hinxton, UK) and of the EMMA node at the Centre National de la Recherche Scientifique-Centre de Developpement des Techniques Avancees pour l'experimentation animale (CNRS-CDTA, Orleans, F). The project will be co-ordinated with related activities developed by the reference Mouse Genom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'FLOODWATER RECHARGE OF ALLUVIAL AQUIFERS IN DRYLAND ENVIRONMENTS', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The WADE project aims to assess long-term (decades to centuries) water resources in selected semiarid to hyperacid ephemeral river basins by determining long-term transmission losses from floods and quantifying floodwater recharge into alluvial aquifers. An innovative approach will be applied based on three principal research themes.1) Palaeoflood hydrology will be used to determine long-term flood magnitude and frequency in order to quantify the frequency of recharging flood events.2) Surface and sub-surface hydrology will be monitored in order to quantify transmission losses through the riverbed into the alluvial aquifers. The combination of these two mythologies will be able to quantify long-term aquifer recharge through flooding.3) The final research theme focuses on thesauri-economic issues related to the use of alluvial aquifer groundwater within the study catchments. The research will be undertaken in 4 research basins, twinning catchments in Spain and Israel with study catchments in Namibia and South Africa.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Models of Structure in Music'.

assistant: **Concept**

Music is an art form with a very long history, and continues to engage millions of people today. Music Information Retrieval (MIR), the exciting interdisciplinary science that brings together music and computer science, is a growing field of research with the potential to enrich computer science knowledge while creating real-world applications that everyone can benefit from. While the marriage of art and science is often troublesome, MIR has the benefit that many aspects of music are highly structural and have been subject to formalisation for a long time. Formalisation and computers go hand in hand, and MIR researchers have therefore been developing models of musical structure for many years, and putting them to use in several applications. However, such models, so far, have had limited impact; they're commonly restricted to one specific aspect of music, can be hard to implement computationally, and are often too technical to be used directly by musicologists who are not familiar with programming details.However, models are valuable. Unlike machine learning approaches, model-based MIR provides a real insight about the underlying structure, and can benefit from the input of musicologist experts. Furthermore, a single model can be applied to multiple important MIR tasks. The research goal of this project is thus to give musical models the impact they deserve, advancing the practical embodiment of hierarchical musical structure-in its various forms-in computer science through the development of new, functional Models of Structure in Music (MoStMusic). Specifically, I intend to develop functional models of musical form, melody, and harmony that enable an easy, fast, and flexible way of creating model-enhanced MIR applications. As a showcase of such an application, I will c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of a new biomolecule to better control reproduction in fish' (EASYFISH), addressing dissemination and exploitation.

assistant: **Impact**

Fish farming is growing at 8% a year and will soon be the main source of fish for consumers. It supplies more than 34% of the world's fish consumption. Nevertheless, due to captivity environment some species have reproduction problems with no spontaneous ovulation in females and no spermiation in males. In some farmed freshwater species (ie, Carp, Salmon, Trout) and marine species (ie, Sea bass, Sea bream) the growth phase of reproductive development occursin captivity in contrast to oocyte maturation and ovulation in females, and spermiation in males that do not occur spontaneously. This problem requires exogenous hormonal therapies which are the only way to produce fertilized eggs reliably. In other species, these hormonal manipulations are used only as a management tool to enhance the efficiency of egg production, increase spermiation and facilitate hatchery operations.ReproPharm Vet developed a first in class monoclonal antibody RP01 and its fragment RP001, that are able to potentiate the activity of endogenous FSH and LH in mammals such as rat, bovine, ovine, porcine species. RP001 fragment can induce ovulation in female and stimulate spermatogenesis in male without any exogenous hormone injection. When injected, it acts directly on circulating FSH and LH hormones by binding to them and potentiating their activity. RP001 is more effective than conventional hormonal treatments it induces a better ovulation rate in polyovulating species and a better steroidogenic response in every species.Treatment with potentiating RP001 would be a highly innovative solution, hormone free, which could be a disrupting product in fishing market if we demonstrate its efficacy on fish FSH and LH. Its added value would be a more efficient method to induce ovulation and spermatogenesis wi