RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Molecular mechanisms of synapto-dendritic cargo trafficking' (NEUROTRAF).

assistant: **Concept**

Activity-dependent modulation of synapses is the core mechanism of synaptic plasticity and underlies learning and memory processes in the brain. Understanding dynamic changes at synapses requires a deeper insight in the molecular machinery involved in the transport and trafficking of postsynaptic proteins. Recent studies suggest that the cytoskeleton (microtubule and actin) and molecular motors (kinesin, dynein and myosin) play an essential role in the targeting and delivery of cargos to synapses. Moreover, it has been shown that defects in synaptic cargo transport are common feature of many human neurodegenerative and psychiatric diseases.One of the limiting factors to study synaptic cargo trafficking in living neurons is the lack of appropriate molecular and imaging tools. Recent developments in super-resolution microscopy as well as the progress made in nanotechnology yield many new possibilities to study synaptic trafficking processes in neurons. In this proposal, we will address key issues in synapto-dendritic protein transport by developing novel molecular tools and imaging systems in living neurons. These tools will be utilized to answer a number of fundamental questions: 1) What is the contribution of specific motor proteins to dendritic transport? 2) Do microtubule motors enter dendritic spines and transport cargos in and out? 3) What is the mechanism of cargo movement between neighboring spines? The expected outcomes of this project will contribute fundamental insights into trafficking processes in neurons and deepen our understanding of the molecular dynamics of synapses.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Training network for research into bone Fragility In Diabetes in Europe – towards a personaLised medIcine apprOach' (FIDELIO).

assistant: **Innovation**

Diabetes mellitus has emerged as a novel risk factor for fragility fractures. While in type 1 diabetes the 3-fold overall relative risk for fractures may mostly derive from low bone mineral density (BMD) likely due to the lack of the bone-anabolic hormones, in type 2 diabetes, the fracture risk is increased about 2-fold, despite a normal or even higher BMD. This suggests that bone fragility in each form of diabetes develops by distinct mechanisms that to date remain largely unknown and may require an individualized approach for effective treatment. As the diabetes epidemic is increasing worldwide with aging, and the fractures that are associated with diabetes cause an increase in morbidity, mortality, and healthcare costs, diabetes-induced osteoporosis imposes a significant burden on our society and our healthcare system. FIDELIO offers a comprehensive, multidisciplinary training program for Early Stage Researchers (ESRs) in this emerging field, unravelling i) the biological mechanisms that contribute to altered bone quality parameters with subsequent bone fragility in diabetes, ii) identify predictive markers for patient stratification and individualized interventions, and iii) develop novel imaging techniques to determine bone quality aspects. The research will employ well-defined patient cohorts, preclinical models of diabetic bone disease, in vitro studies, genetic databases, artificial intelligence, and cutting-edge imaging technologies in a highly collaborative and interdisciplinary environment. ESRs will be trained through individual research projects, secondments, residential courses, and webinars provided by a broad range of experts, including bone biologists, clinicians, epidemiologists, geneticists, engineers and entrepreneurs, as well as companies supporting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reusable precast steel-concrete composite floors' to be submitted under Horizon 2020.

assistant: **Abstract**

There is an urgent need for sustainable development in modern societies. The construction sector can play an important role in achieving a sustainable environment, since the production of new materials is an energy-intensive process, which is responsible for about 15% of the global CO2 emissions, and buildings are usually demolished at the end of their useful life producing waste. A more sustainable solution is to develop innovative structural solutions that allow for the reuse of building components directly to new projects. In this way, the construction will produce less CO2 emissions, much less waste will go to landfill, and the natural resources of the planet will be used more responsibly. This project proposes a novel way to connect precast concrete slabs with steel sections that offer the advantages of a) off-site fabrication of all components; b) easy and fast installation on the construction site; c) disassembly of the composite floor; and d) direct reuse of all components in new projects. The project will use experimental testing complemented by numerical analyses to develop the proposed novel structural system. The experiments will provide evidence on the physical behaviour and the ultimate failure modes of the proposed system, whereas numerical simulations using advanced mathematical models will be used to study numerous geometrical configurations and generalise the results of the tests. Based on the results of the tests and the simulations, recommendations for the practical design of the proposed system will be proposed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Controlled Access to Digital Libraries in Europe' (CANDLE) targeting Fourth Framework.

assistant: **Abstract**

The objective is to demonstrate how the CaseLibrary digital management system developed under FP3 can be used to improve the handling of electronic publications acquired by libraries through collaboration with publishers and supplier agencies.No economic or technical models have yet been accepted as suitable for supporting the move towards electronic publishing or the shift from traditional holdings to access to electronic resources. The experience of large international publishing firms will be used as a basis for realistic investigation of how digital library management systems can be used to explore new economic models. This will provide evidence not only in support of rights management (cf. T-ECUP) but should also demonstrate the benefits of migrating from current library systems towards more open solutions.In the digital library environment, end users are represented by digital objects. To achieve improved levels of user service, libraries require IT management functions which until now have been lacking in their automation systems, in particular for rights management, distributed access and security. CANDLE will focus on applying an existing library management system in environments which encourage publishers to offer electronic products to libraries in order to meet user needs by addressing licence metering, control, feedback, monitoring, rights management, access control and promotion.Technical approachCANDLE will add Windows NT server and client support to the Sun Solaris and Windows 3.x platforms. ZNavigator developed under CaseLibrary will also be used for information retrieval in the CANDLE environment. The functionality available to users is defined by the library systems administrator implemented through services provided by a Task Manager which enables cl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'THE PREDICTION OF MEAT QUALITY AT THE EARLY POST-MORTEM PERIOD BY DETECTION OF NOVEL PHYSICAL AND CHEMICAL MARKERS' to be submitted under Fourth Framework.

assistant: **Abstract**

The European meat industry is valued at approximately 70 billion ecus. It accounts for about one third of total agricultural produce. Presently the meat industry faces many challenges which have resulted in a decrease in meat consumption. These challenges derive from many sources especially increasing consumer demands for more healthful and convenient foods, consistent quality, more information and animal welfare. Consequently there is a strong case for the meat industry to be more market-led and less commodity based.The greatest problem for the meat industry in achieving this is the variability in quality of its own product. Despite much work in understanding the scientific basis of meat quality attributes (tenderness, colour, waterholding capacity, juiciness), their evaluation, prediction and control remain elusive within the meat processing plant (i.e. within 48 hours post-slaughter, before despatch). Presently quality can only, in the main, be assessed by the end user and consumer after purchase. Apart from pH, temperature and some visual assessment, there are no indicators measured for quality parameters in terms of sensory attributes, technological properties and nutritional composition.The main objectives are : - to detect and quantify important quality indicators of meat by means of novel  physical and chemical markers at the early post-mortem period;- to predict meat quality at factory level in order to guarantee its commercial quality for the end user and eating quality for the consumers;- to improve the quality of European beef, pork and lamb through strategic measurements and selections based on novel quality indicators. A team of eight multi-national partners has been assembled with tremendous expertise in the fields of physical and chemical measurements in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Exploring the scope for a shared European pluralistic ethos; a comparative investigation of religious and secular ethically-derived requests for exemption from the law in an enlarging Europe' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The politics of handling cultural diversity is one of the major issues in the construction of Europe, especially in light of the enlargement of the EU. The EuroEthos project aims to explore the possible scope for a shared European ethos through the analysis of political and legal questions concerning issues of religious and secular ethics-based requests for exemption from the law, in the belief that the study of such issues provides precious indications on how societies try to handle a plurality of values.The project has four objectives:- to develop and organise knowledge on cases in which religious and ethical secular values lead to the definition of politically relevant claims;- to raise historical awareness of the relationship between plural values and political stances;- to analyse the influence of a diverse cultural heritage on the political views of citizens in the enlarging Europe;- to study the scope for a European ethos as a precondition for political integration.To achieve these objectives, the project will compile a database of cases of requests for exemption from the law, and run a comparative analysis focusing on two case studies. Building on this analysis, normative guidelines will be developed regarding the specific forms in which a pluralistic European ethos could be realised.The knowledge-based study on the possibility of fostering European political integration through the creation of a shared ethos will produce a better understanding of the impact of plural values and religions in societies across Europe, and of their role in relation to changes in society, as required by the objectives of the FP6 (activity 7.2.1).The project's dissemination activities include conferences and a publication strategy aiming to communicate results to an academic and non-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Identifying new Markers and Homing Profiles involved in Lymphocyte Migration to the Female Reproductive Tract' (FRT-HOMING) targeting Seventh Framework.

assistant: **Abstract**

The effort to develop vaccines that can elicit mucosal immune responses in the female reproductive tract (FRT) against sexually transmitted infections (STI) have been hampered by an inability to accurately measure immune responses in the genital tract. Vaccines against STIs should generate localized memory responses at sites of potential exposure to provide better control of infection. Critically, lymphocytes isolated from the genital tract will migrate back into the FRT when transferred into a naïve recipient. Yet, the repertoire of trafficking molecules expressed on cells that will home to FRT is still unknown. The hypothesis of this project is that lymphocytes induced by FRT immunization traffic transiently in blood expressing a specific set of homing markers, but are selectively retained in the FRT after transmigration. By isolating cells from blood shortly after mucosal FRT immunization in animal models and FRT-mucosal infection in patients, we will be able to detect the potential specific integrins and homing receptors responsible for lymphocyte entry into the FRT. The goal is to identify specific integrins and homing receptors expressed on circulating T and B lymphocytes that direct their migration to the female reproductive tract during the brief period in which mucosal lymphocytes re-circulate. Direct comparison of gene and protein expression profiles using microarrays and mass spectrometry technology on subsets of purified peripheral blood will be performed in patients and murine models. Differentially expressed candidate molecules selected from these functional genomic analyses will be confirmed and validated in patients and by competitive homing assays in vivo in mice. Identifying the profile characteristic of lymphocytes migrating to the FRT soon after vacc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High-density mammos disc in blue wavelength and Investigation of MAMMOs for SIL Technology' (MAMMOSIL).

assistant: **Concept**

To meet the storage requirements that are growing at an exponential rate, the magneto-optical (MO) storage technology offers the most promise with expected area density over the 100Gbits per square inch in the next 5 to 10 years. The partners of the MAMMOSIL project (4 industrials, 1 university and 1 research centre) have decided to take part in the MO emerging technologies by developing a high-density MAMMOS (Magnetic Amplifying Magneto-Optical System) media. This project will allow the European companies to follow the MO technological roadmap through the development of a high-density MAMMOS disc and related prototype drive, working at blue wavelength and high numerical aperture optics to achieve 40Gbytes on a 120 diameter disc, and investigation of a very high-density MAMMOS disc for near-field optical system, based on the emerging Solid Immersion Lens (SIL) technology, to achieve the expected 100Gbytes on a 120 diameter disc in the next 6years.Objectives:Driven by the multimedia revolution and Internet applications the storage requirements are growing over the next decade at an exponential rate, in particular capacities of the discs in the removable storage consumer market. The Magneto-Optical (MO) technology offers the most promise to meet such requirements with expected area density up to the 100 gigabits per square inch in the next 10 years. The MAMMOSIL project is a long-term RTD project that aims at enhancing the position of the European companies in the emerging MO storage technologies.The objectives are :i)development of a high-density MAMMOS disc and related prototype drive, working with blue wavelength diode and high numerical aperture optics to achieve at least 40 gigabytes (GB) on a 120 diameter disc;ii) investigation of a ultra-high-density MAMMOS disc fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'The role of partially unfolded states of proteins in biological signal transduction: Photoactive Yellow Protein and AppA'.

assistant: **Innovation**

Partially unfolded and/or molten-globule like states are known to play an important role in vitro, in particular for photoreceptor-mediated signalling. It has been reported that this intrinsically unstructured state offers important advantages; however for a better understanding of this phenomena, structural information about unfolded states of proteins is crucial. The aim of this project is to increase understanding of the functional role of partially unfolded states of proteins that are involved in biological transudation. This will be achieved by characterizing the structure and interactions of these states in the model system PYP (Photoactive Yellow Protein). This system is involved in designating pathway of a cryptozoic light receptor, which is believed to mediate negative photo taxis in certainhalophilic bacteria. The methods to be developed for characterizing these states will then be applied to theflavoprotein Appal, a recently discovered photoreceptor protein from Rib. Sphaeroides. The main experimental technique that will be employed is high-resolution NMR spectroscopy, in combination with computational tools, based on the Molecular Dynamics approach. They will be developed to describe the ensemble of conformers that constitute a (partially) molten globule state of a protein. These tools will have important implications for the more general questions surrounding (functional) protein folding and unfolding. Folding is thought to be involved in human pathologies such as Alzheimer disease and Creutzfeldt-Jakobdisease. Since the interaction partners are known for the Appal photoreceptor protein, this for the first time allows the complete reconstitution of the in vivo signal transudation chain, initiated by Appal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Design and AI for sustainable and safe motorCYcles'.

assistant: **Concept**

Tarform launched its first two fully functioning concept prototypes on October 9th, 2018. To date Tarform has received over 700 reservations, more than 120 articles published in design and tech media and requests for partnerships from global leaders in the automotive sector, evidently proving there is a demand for this vision in the motorcycle industry. For example, the concept prototype is currently part of the new exhibition, Electric Revolution, at the Petersen Automotive Museum in Los Angeles. Adding to that, Tarform has a dynamic and entrepreneurial team with competence in a variety of sectors relevant to our mission and vision. Sectors including AI, excellence in industrial design, proficiency in software development, strong entrepreneurial drive as well as advanced digital communication capabilities.The goal of phase 1 is to investigate the technical and financial feasibility of the innovation, being an artificial intelligence platform for increased safety when riding a motorcycle, and get official commitments from a number of test partners on top of the ones we have already secured.The project will have a substantial impact in Tarform AB’s performance, with a very promising growth trajectory. By 2023, Tarform expects to reach additional revenue of €45M and create 80 new jobs in various sectors such as manufacturing, marketing, AI technology, sustainability and design. In addition to creating a more sustainable world by introducing an electric motorcycle free of CO2 emissions, the goal is also to vastly diminish injuries and death tolls relating to motorcycle use by integrating new technological features in the motorcycle utilizing the technological innovations that is currently available. Considering the initial investment budget for the Phase 1 and 2, a financi