RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Protection of cardiometabolic inflammation by modulation of myeloid glutamine homeostasis'.

assistant: **Objectives**

The metabolic syndrome (MetS) represents one of the major public health challenges worldwide. It reflects a combination of medical disorders that, when occurring together, increase the risk of developing diabetes and cardiovascular disease. The prevalence in the USA is estimated at 30% of the population and the European community follows this trajectory. It is now recognized that the state of chronic low-grade inflammation may favor the onset and progression of the MetS. While the notion of metabolic flexibility in hematopoietic cells has recently emerged in several inflammatory diseases, the origin of this immunometabolic alteration in the MetS remains elusive. There is a growing appreciation that the apportioning of nutrients into different metabolic pathways can support or direct functional immune and hematopoietic changes. Glutamine is the most abundant amino acid in the plasma and an important energy source through glutaminolysis. Despite its potential proliferative and/or immunosuppressive function and the strong association between high glutamine-to-glutamate ratio with cardiometabolic traits, the underlying mechanisms are poorly understood. Thus, there is a considerable therapeutic interest in better understanding the mechanisms linking glutamine to cardiometabolic risks and in particular cardiometabolic inflammation. In PROGLUTASIS, we will investigate the metabolic and immune regulation of glutamine homeostasis in the metabolic syndrome. We will validate the contribution of glutaminolysis in cardiometabolic inflammation, including obesity, diabetes and atherosclerosis through its role on hematopoiesis and macrophage dynamics. Given the ubiquitous association between glutamine and chronic metabolic stress, we expect that identifying the underlying molecular mec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EnergyMate, the first energy efficiency-based software providing users an easy way to understand their energy consumptions' to be submitted under Horizon 2020.

assistant: **Abstract**

EnergyMate, the first energy efficiency-based software providing users an easy way to understand their energy consumptions.Residential energy consumption represents the 25% of all EU energy consumption. In this context, is clear that the reduction of energy consumption in the residential sector should play an important role in energy efficiency programs and policies. Currently, energy consumers and energy utilities face various barriers that deter them from adopting energy efficiency measures: (i)Energy bills difficult to understand by energy consumers; (ii) low-optimized energy consumptions; (iii) low quality services by energy utilities, resulting in a large number of unsatisfied customers. At Energintel S.L (Asturias, Spain) we have developed a smart solution to overcome these barriers. EnergyMate provides users information about their energy consumptions in a natural language format easily understandable by users, suggesting personalized recommendations, and allowing to adapt their behavior to the hourly energy prices. It has been estimated an annual reduction of 25% in energy consumption and an increase of 30% of the customer´s satisfaction with EnergyMate. Based on the good performance of our prototypes being currently tested in Spain, we aim to optimize the software and scale-up the technology to fulfill the technical needs of different European markets. This market, depends on the roll-out of smart meters, which is expected to be 200 million by 2020. Additionally, in the first stage of commercialization EnergyMate expects to cover at least the 52% of the market for energy retailers (over 2.000 companies). This market, with such growth potential (predicted to increase at 8.1% CAGR up to 2019), could greatly benefit from our smart solution. €6.64M  sales projectio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Impact of climate change on light-related carbon fluxes in the Arctic Ocean'.

assistant: **Innovation**

We currently witness in the Arctic: 1) a decrease in summer ice cover that exposes sea surface to solar radiation and physical forcings, 2) permafrost thawing and increased river runoff, both leading to an increase in the export to ocean of organic carbon previously sequestered in the Tundra, and 3) an increase in ultraviolet radiation. These three phenomena potentially favour a growing mineralization of organic carbon through photo-oxidation taking place in the surface layer of the ice-free Arctic Ocean waters, resulting in an acceleration of the increase in atmospheric CO2. At the same time, the exposure of a larger fraction of ocean surface to sun light and the possible increase in nutrients brought by rivers lead to larger autotrophic production and sequestration of organic carbon. The general objective is to determine the absolute significance of organic matter photo-oxidation and of primary production, and their relative balance in the Arctic Ocean.  Diagnostic (Part 1) and prognostic (Part 2) approaches will be developed to address the problem quantitatively.  Part 1: Based on existing and new data collected in situ in different regions of the Arctic Ocean, we will developed 1) a model for light propagation through atmosphere and within ocean, 2) diagnostic models for the two light-related processes of interest, and 3) algorithms for the processing of ocean colour remote sensing data specifically in the Arctic Ocean. Organic matter photo-oxidation and primary production will then be estimated using different sources of remote sensing information (UV, clouds, ice, optical properties of surface waters) at various space and time scales.  Part 2: The diagnostic models will be integrated into a coupled physical-biological ecosystem model including bacterial activity,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The impact of asthma on dendritic cell development; analysis at the cellular and the molecular level' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Allergic asthma is a chronic inflammatory disease of the airways and a worldwide problem. Dendritic cells (DC) have a key role in the development of this disease, making them interesting targets for therapy. Novel asthma therapies could involve interference with the development and relative abundance of functionally specialized lung DC subsets. Allergen exposure drastically changes airway DC subset distribution and preliminary experiments show effects on myeloid bone marrow progenitors. We hypothesize that DC precursor development, selection and differentiation choices are affected by allergen-induced airway inflammation and this might affect the outcome of the pulmonary immune response to allergens. Here, we aim to elucidate how asthma affects the distribution and differentiation capacity of DC progenitors/precursors at the cellular and the molecular level. In a novel house dust mite (HDM)-driven mouse asthma model, we will analyze HDM-induced changes in the distribution of bone marrow, circulating and lung-resident progenitors/precursors. In vitro development of progenitors/precursors isolated from HDM-exposed and control mice will be compared to identify imprinting effects on differentiation capacity. To find the mechanism by which asthma alters or imprints DC development from progenitors/precursors, HDM and asthma-associated cytokines will be added to in vitro DC differentiation cultures to evaluate their effects on development. The most promising candidates will be tested by analyzing DC development in HDM-exposed knockout mice and 50/50 mixed bone marrow chimeras. Moreover, gene expression profiles from progenitors/precursors isolated from HDM-exposed and control mice will be compared to identify new regulatory networks. Finally, findings will be validated in in v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Study of genetic and environmental factors in the pathogenesis of the most frequent chromosomal anomalies', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Clinical and genetic examination of profanes and their parents, creation of Donavan, epidemiological case-control study of impact of environmental risk factors in aetiology of developmental disorders due to the most frequent chromosomalaneuploidies in regions of Russia and Ukraine with environmental pollution including Chernobyl radiation exposure. Use of improved 24-colour FISH, micro-Chan rnulticolor PRINS supported by new generation of DNA probes and quantitative fluorescent PCR for rapid and reliable aneuploidy diagnosis in single cells ormicroquantity of cells and for the use in preconceptual, prefertilization, preimplantation, prenatal and postnatal diagnosis , prevention and better care for affected profanes. The ascertainment of the role of environmental risk factors in the aetiology of aneuploidies by analysis of epidemiological data and by determination of parental and meiotic origin of the aneuploidies .
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-channel measurement and control system based on resonant piezoelectric crystal sensors' under Fifth Framework.

assistant: **Concept**

The proposed project aims to the development of a multi-channel system for monitoring and control based on resonant piezoelectric crystal sensors (QxSens). Novel resonant sensors are used for the determination of various physical measurement quantities of technical importance. The advantages of these sensors are high precision, high sensitivity and dynamic range, independence from strong electric and magnetic fields, and a frequency output signal ideally suitable for digital processing. The universally applicable QxSens system offers temperature control, measurement of viscosity, density, and speed of sound in industrial processes of all kinds and therefore can contribute to a higher quality of many products. The benefits for product quality enhancement will be demonstrated in lyophilization of food, characterization of fuels, lubricant and hydraulic oils, and rayon fibre process control.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'CERTIFIABLE LOCALISATION UNIT WITH GNSS IN THE RAILWAY ENVIRONMENT' (CLUG).

assistant: **Innovation**

According to the ERAccording to the ERA 2015 Report on ERTMS Longer Term Perspective, GNSS could prove a game changer for the European railway network by enabling a significant reduction of trackside equipment and by improving localisation performance. The conclusions of the STARS project have confirmed this potential. However, fusion with other sensors will be necessary to mitigate the known impact of local effects on GNSS performance.Capitalising on the achievements of EC and GSA funded projects, collaborating railway companies, i.e. SBB, DB and SNCF, would like to propose the project CLUG. This project will perform a mission analysis/needs identification and a preliminary feasibility study of an on-board localisation unit with the following characteristics:> failsafe on-board multi-sensor localisation unit consisting of a navigation core (IMU, tachometer, etc.) brought in reference using GNSS, track map and a minimal number of reference points;> on-board continuous localisation system that provides location, speed and other dynamics of the train;> operational and interoperable across the entire European rail network;> compatible with the current ERTMS TSI or with its future evolutions.To achieve its objectives,the CLUG's management and the design and development of the localization unit will follow agile processes taking into account former projects results – especially STARS – as well as observations resulting from new test campaigns.The CLUG consortium comprises railway companies (SNCF, DB Netz and SBB), railway signaling industries (CAF and Siemens), navigation specialists (Airbus Defense & Space, Naventik, FDC), a research institute (ENAC)  and a certification expert (Navcert).Ultimately, this project is the key enabling technology for the future-proof developmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Mechanisms of the formation of ordered mesoporous, inorganic materials from organised molecular assemblies'.

assistant: **Objectives**

The synthesis of well ordered mesoporous materials with defined porosities, scientists at the post-doctoral level in establishing the mechanisms of the surface areas and acidities is currently attracting world-wide interest, and their production is of considerable interest for European Industry. formation of the organized assemblies and their conversion to the porous solids. Although in some cases it will be worthwhile for the researcher to However, the mechanisms of formation through organized inorganic/organic molecular assemblies have not been properly established - thus placing stay in one laboratory we are also keen to promote a rotation scheme in severe limits on the ability of scientists to pursue logical pathways to which the researcher spends 18 months in two laboratories. Shorter stays of one month duration are suitable for closely defined experiments. We also the synthesis of useful materials. It is the principal objective of this feel confident that the employment prospects of the researchers at the end project to obtain a fundamental understanding of the sequence of events leading to the final products, by bringing together a unique combination of the project are good because the industries will be able to use the mechanisms so established to develop materials in later projects. skills represented by various partners. The mechanistic knowledge thus obtained will be related to the structures and properties of the organized assemblies and of the final mesoporous substances. We will start by examining the silica-based systems, since there is already a basis of knowledge in this area, albeit incomplete. In year 2, the project will examine zirconias to establish whether the same or different mechanisms operate. In the final year. we will turn our attention to va
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fuctionalised Innovative Carbon Fibres Developed from Novel Precursors With Cost Efficiency and Tailored Properties' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Innovative processes with streamlining and improved control will be conducted in FIBRALSPEC, through Unit for Continuous PAN-based Carbon Fiber Pilot Production. Testing of laminates and prepregs production based the new developed carbon fibres followed by manufacturing of laminates/coupons and high-performance filament wound tubes are also foreseen (equipment for delivering precise volumes the matrix (resin) in high and low-capacity to impregnate the fibres and bundles will be developed). The project also efforts on functionalization will be mainly focused on cost reduction, mechanical and chemical property improvement. Novel CF precursors will be developed (silicon carbide, textile-grade PAN, polyolefins, and lignin); in parallel, the suitability of a new environmentally friendly pitch will be assessed, obtained from anthracene oil, for the preparation of isotropic carbon fibres. The project’s carbon fiber conversion technology will pyrolysis process to convert PAN precursor fiber into PAN-based carbon fiber and activated carbon fiber. Innovative surface treatment will improve the step of treatment of the carbon fiber surface being indispensable for productions in series. As for recycling and used of recycled CFs, new techniques will be used to provide commercially-relevant products that are manufactured from waste carbon fibres. Mathematical modeling will be conducted so as to determine properties of CFs and composites, together with cost modeling; life cycle assessment will assist in possible commercial risks that will be continuously estimated during the project and quantify/assess the environmental impact of the materials that will be used. Industrial partnership will ensure the impact of the research efforts, convincingly proving scalability towards industrial ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Ethics and Ageing' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Population aging will raise formidable ethical challenges for the European Union in the coming decades. Declining fertility rates and increased longevity are gradually increasing the ‘dependency ratio’ – the ratio of persons aged over 65, to persons of working age. In 2010, the EU-wide dependency ratio stood at 26%; by 2050, it will rise to 50% (Eurostat projections). As the balance in numbers shifts from citizens who work to those who are retired, the question of how to sustain the key programmes of the welfare state becomes ever more pressing. How can EU public policymakers best maintain their commitment to social solidarity under conditions of population ageing?This research project proposes a comprehensive analysis of the ethical challenge posed by population aging. It is based on the following guiding observation: while European Union policy-makers (especially in the European Commission) are conscious of the fact that the EU needs an overall strategic approach to this challenge, they do not have at their disposal scholarship that provides an ethical analysis of this challenge at the appropriate level of generality.The project will be based in the Department of Philosophy of Law at Universitat Pompeu Fabra (UPF). It will be supervised by Professor Andrew Williams, one of the world’s leading political philosophers, under the auspices of the UPF research group, the “Philosophy of Law”. Additionally, the project will be developed in dialogue with one of the world’s leading social scientists on the welfare state and population aging, Professor Gøsta Esping-Andersen, who runs the “DEMOSOC” research group at UPF. The project will thus have an interdisciplinary character, moving back and forth between ethics and social science, and more specifically, between these two rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Dissecting the gene regulatory mechanisms that generate serotonergic neurons and their link to mental disorders' (SEROTONINANDDISEASE) under Seventh Framework.

assistant: **Objectives**

Mental disorders constitute a human an economic burden for developed countries. Many mental disorders are linked to serotonin dysfunction, but the exact mechanism underlying these disorders is not well understood. Serotonin Related Mental Disorders (SRMD) are multigenic, making the identification of these mechanisms a difficult task. Understanding the molecular mechanisms that generate serotonergic neurons will provide us with the tools to identify mutations that could predispose to SRMD. In this grant we will use a multidisciplinary approach to dissect the transcriptional mechanisms that generate serotonergic neurons and use this knowledge to identify genetic links to SRMD. Serotonergic neurons are very ancient in evolution and enzymes and transporters responsible for the production of serotonin (serotonin pathway genes) are very well conserved in all metazoans. We would take advantage of this evolutionary conservation and use the genetic amenability of C. elegans to dissect the genetic mechanisms responsible for the generation of the serotonergic neurons. We will apply the lessons learned from C. elegans to unravel analogous mechanisms regulating mouse serotonergic differentiation. Our preliminary results show that the serotonergic pathway genes are co-regulated by the same factors and that this mechanism is evolutionary conserved. We will identify the cis-acting sequences (serotonergic motif) and trans-acting factors responsible for the activation of the serotonergic features, both in worms and mice. Finally, we will apply our knowledge on serotonergic differentiation to identify genetic association to SRMDs. Mutations in the serotonergic motif could lead to defects on the expression of the serotonergic genes, resulting in a dysfunctional serotonergic neuron. We will