RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Metrics framework for improving SME total operations' (MEFISTO).

assistant: **Innovation**

The project addresses key areas which have a major effect on the profitability of any organisation producing software. The specific objectives are to:- improve the accuracy of cost estimates- use metrics to identify ways to improve the general software development process- increase the effectiveness of the capture and exploitation of experience.THE EXPERIMENTThe estimating experiment consists of two parts: the first to collect data to calibrate the chosen techniques, and the second to use the new techniques and evaluate them. Evaluation will be based on a comparison of the accuracy of the estimates obtained. Estimates will be produced for a wide range of projects. The experiments for improvement and experience involve the identification of suitable metrics, the collection of associated data on a number of projects and the evaluation of the metrics. The evaluation will compare the cost of identifying and collecting the metrics with the value they give to the business.The Software Engineering Centre (SEC) has about 130 staff.EXPECTED IMPACT AND EXPERIENCEThe impact within the SEC is expected to be:- an improved metrics process leading to more accurate cost estimating- identification of weaknesses in the development process- the establishment of a longer term and continuing process improvement environment, through the creation of a metrics culture". All will benefit the SEC and its customers alike. The SEC has links not only to the Ministry of Defence but also to industry, and will use these to disseminate the benefits and experiences to a wide audience."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CAPSizing ICE caps: identifying tipping points through global modelling' (CAPSICE).

assistant: **Concept**

Ice caps have been major contributors to sea-level rise over the past decades and also in the coming century they are projected to further lose a substantial part of their volume, maintaining their position as one of the main sea-level rise contributors. One of the drawbacks of these projections, however, is that they are based on approaches that strongly simplify ice cap processes by relying on volume-area scaling methods or parameterisations derived from observations on mountain glaciers. Consequently, these projections fail to provide insights on feedback processes that can have an important impact on the future evolution of ice caps.Within this project, I want to implement GloCAP3D, the first global 3-D ice cap evolution model in which surface mass balance and ice dynamics are explicitly accounted for, in order to improve future projections of ice caps. Firstly, I will focus on calibrating GloCAP3D, which is a crucial step to ensure accurate future ice cap projections. For this, remote sensing products and other increasingly available datasets will be included. Secondly, I will assess the role of tipping points in the future evolution of ice caps and identify potential points-of-no-return, beyond which the loss of individual ice caps is irreversible. Particular focus will be on tipping points related to the surface mass balance - elevation feedback and on tipping points resulting from a potential strong reduction in the refreezing potential. The incorporation of ice dynamics will also allow to further quantify the mass loss through frontal calving, which can regionally be a major annual mass loss driver. Finally, through this novel interdisciplinary approach it will be possible to provide improved estimates on the future sea-level contribution from ice caps. Given p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Zinc-air Flow Batteries with High-entropy Alloys (ZAIRWAYS)' under Horizon Europe.

assistant: **Concept**

The global transition from fossil fuels to sustainable energy sources is crucial to address the current energy crisis and environmental challenges. However, renewable sources like solar and wind are intermittent, making energy storage solutions critical. Zinc-air flow batteries (ZAFBs) have emerged as promising candidates for long-duration energy storage due to their high energy density, safety, and low cost. Yet, challenges such as zinc dendrite formation and byproduct accumulation in conventional systems limit their efficiency and lifespan.The ZAIRWAYS project aims to revolutionize ZAFB technology by incorporating High-entropy alloys (HEAs) into the cathode design (catholyte tank). HEAs, with their unique combination of five or more elements, offer exceptional structural integrity and electrochemical properties, making them ideal candidates for enhancing the oxygen reduction and evolution reactions in ZAFBs. By optimizing HEAs, ZAIRWAYS will address critical issues such as discharge duration and cycling stability, paving the way for a new generation of sustainable energy storage systems.State-of-the-art research has explored HEAs for electrochemical applications, but their use in mediated oxygen reduction reactions (ORR) within ZAFBs still needs to be explored. This project, with its unique focus on synthesizing HEAs using a colloidal surfactant-free (CSF) method and testing their performance in real-world ZAFB systems, is of significant importance. Planned secondments with industrial partners will ensure the practical application of this research.The expected impact on the fellow includes the development of cutting-edge skills in advanced materials synthesis, energy storage technology, and collaborative research. This project will foster interdisciplinary expertise,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Hybrid Fluorescence Optoacoustic Imaging' (HIFI), addressing dissemination and exploitation.

assistant: **Impact**

Optical imaging tools are in high demand by the biomedical research and clinical communities for applications that greatly impact the life sciences.The invention of fluorescent molecular tomography (FMT) a decade ago  can be considered a breakthrough in optical imaging, as it allows for unprecedented, in-vivo, non-invasive and quantitative 3D imaging of fluorescent probes. However, it has been recently shown than its performance can be greatly improved using a priori information for the tomographic algorithm regarding the distribution of optical parameters in tissue.Multispectral Optoacoustic Tomography (MSOT) is a new non-invasive medical imaging modality that is able to retrieve the 3D distribution of light energy deposition in small animals in vivo, and not invasively. Its  high resolution has revolutionized the field of optical imaging, having many important applications in preclinical research and clinical diagnosis.By combining MSOT and FMT in a hybrid system, a unique synergy is established, since MSOT can potentially provide the input needed by  FMT to achieve a radical improvement in its imaging performance, not to mention that the simple combination of the molecular information yielded by FMT with the functional and anatomical information yielded by MSOT is certainly useful for biomedical researchers and clinics. Furthermore a FMT/MSOT system will  be capable of serving as a cheap diagnostic tool for rheumatoid arthritis (RA), shifting the expensive MRI  diagnosis paradigm, and for the first time rendering economically viable the frequent monitoring of this aging-related disease, which is a major cause of mortality in Europe.The objective of this project is to develop the first hybrid FMT/MSOT system, engineering the optimal tomographic approaches for exploiti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Identification and development of vaccine candidates for Buruli Ulcer Disease'.

assistant: **Innovation**

Buruli ulcer disease (BUD), caused by Mycobacterium ulcerans, is a neglected bacterial infection of the poor in remote rural areas, mostly affecting children. BUD, the third most common mycobacterial disease in immunocompetent humans after tuberculosis and leprosy, is most endemic in West Africa, but cases have been reported from more than 30 countries. BUD is a mutilating disease leading to severe disability. Treatment with antibiotics is possible but is long-lasting and requires injections, shows treatment failures and drug resistance may occur. A vaccine against M. ulcerans would protect persons at risk in highly endemic areas and could be used as a therapeutic vaccine to shorten duration of treatment and to prevent relapses. The general objective of BuruliVac is to identify and develop novel vaccine candidates suitable for translation into clinical application. This objective will be achieved by a multidisciplinary approach involving among others basic and applied research in immunology, bioinformatics, molecular genetics, tropical medicine, microbiology and clinical bacteriology. As currently no existing vaccine lead candidate is available, the consortium will identify and develop new vaccine candidates of different types, will evaluate them using bioinformatics, applied genomics and proteomics and will subject them to consecutive test systems. For evaluation of vaccine candidates regarding their application in humans, the consortium will also study the immune response and disease immunopathology to define correlates of protection. Essential pre-clinical testing in vitro and in vivo will select a small number of candidates that is amenable to be introduced into clinical studies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of intervention strategies against sars in a European-Chinese taskforce' (DISSECT), addressing dissemination and exploitation.

assistant: **Impact**

This research proposal is comprehensive, encompassing all the complementary aspects necessary for the development of intervention strategies, including vaccination, immunotherapy, and antivirals to protect against SARS. In addition, techniques and materials will be generated to develop diagnostic kits that will lead to the identification of infected individuals at very early steps of the disease, and to differentiate between vaccinated and naturally infected people. The first focus of the project is vaccine development. Accordingly, a set of complementary strategies is proposed to guarantee the success. These strategies include classical" vaccines (such as whole inactivated virus), subunit vaccines, and state of the art-recombinant technology derived vaccines. The second focus of the project is on the state of the art-therapeutic approaches, ranging from the use of monoclonal antibodies to specific antivirals. For achieving the primary objectives of this project, the availability of an adequate preclinical setting for SARS-CoV research, including animal models, as well as the access to relevant clinical samples are absolute preconditions. These all met in this project, as a result of the expertise of the individual groups involved. To develop this comprehensive project, laboratories from the European Union and China are collaborating. The laboratories from EU member states (Spain, UK, and The Netherlands), have a long term experience (more than twenty years) in coronavirus pathology, immunology and molecular biology. The groups from China have key knowledge on the onset and evolution of SARS, high technology, and have generated large collections of biological materials: viruses, sera, tissues, clinical and epidemiological data."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nourishing PRObiotics to Bees to Mitigate Stressors', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In the last decades, bees have been threatened by a number of biotic and abiotic stresses, which strongly affect beehivesintegrity. Consequently, the beekeeping sector together with ecosystem and agricultural sectors depending on pollinatorssuffer of missed pollination. Nosema ceranae is a bee gut parasite that has received particular attention in the last yearsbecause it causes bee colonies to collapse due to energy and nutrient deficiency. Furthermore, the bee gut microbiotaundergoes a dysbiosis process following infection. N. ceranae virulence in infected bees escalates when forager beesuptake sub-lethal doses of insecticides such as Neonicotinoids from the polluted agricultural environment surrounding thehive. The European Union banning of antibiotics for therapeutic use in the beekeeping sector approved in 2001 has deprivedbeekeepers of Fumagillin-B, the sole antibiotic previously available to control Nosema sp.. The need to find alternativetreatments to fight bee diseases has led researchers to the study of ecofriendly practices. Our proposed research aims todevelop a strategy for the health of the bee gut based on microbial and plant resources to inhibit N. ceranae proliferation andto mitigate the effect of synergic bee stressors. The project will be developed by a consortium formed by 4 researchinstitutions and 3 SMEs of 3 different European countries and a third country (Argentina). Researchinstitutions will do the experimental work on bees aimed at the definition of a strategy based on the use of beneficial bacteriaand plant extracts and at the evaluation of the impact on the bee gut of the developed formulation. SMEs will contribute tothe choice of the ingredients of the prototype formulation and at finding a strategy to produce it. ESR and ER will performsec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments' (MEDLEM).

assistant: **Concept**

The project entitled: “Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments”, with acronym MEDLEM, has a general objective to foster exchanging knowledge and sharing different culture and approaches in reaching high level of excellence, in research and innovation, in the framework of this field.The project is aimed at strengthening research collaboration through active networking, staff exchange and dissemination activities between 4 European organizations from Serbia, Germany and France as well as 2 non-European institutions from Thailand and Australia, in linking the fields of microfluidic electronic devices, optimal drug administration, fractional pharmacokinetics, and leukemia treatments. The project will exploit complementary competencies and synergies of the participants, and enable knowledge sharing via international/inter-sectoral mobility, based on secondments of research staff. The consortium offers a unique opportunity that creativity and entrepreneurship will flourish and will help exchanged personnel to turn creative ideas into innovative electronics products, reaching breakthroughs in modelling, drug administration and improvements in therapy protocols.The main technical goals of the joint research programme are:- Development of fractional pharmacokinetic models and procedures for parameter identification within these models;- Design and fabrication of microfluidic device with in-built electronics for optimal drug delivery protocol;- Pharmacokinetics determination of the pharmaceuticals for leukemia treatments and its testing in vitro and in vivo systems;- Optimal control problem, its numerical solution and implementation.The proposal will develop new research links and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Improved Statistical Monitoring Procedures for Attributes with Applications in Public Health Surveillance' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Public health surveillance consists of the systematical collection, analysis and interpretation of public health data in order to (i) understand trends, (ii) detect changes in disease incidence and death rates, and (iii) plan, implement and evaluate public health policies. The monitoring of incidence rate of an event of interest (e.g., cancer incidence, surgical failures, etc.) is the main scope of public-health surveillance methods. For example, an increase in the incidence rate of a disease represents an increased risk to the public. Hence, the quick and accurate detection of such changes will lead to the development of effective medical and non-medical intervention strategies that will delay or reduce the impact of the outbreak in the community.The monitoring of public-health data over time is a scientific area closely related to the domain of statistical process control (SPC); the primary tool of SPC is the control chart. In case of public-health surveillance, the data are often discrete, assuming to follow a specific probability distribution. Thus, the application of ordinary control charting techniques is not valid. Therefore, new improved schemes are needed in order to deal effectively with the health-related processes, without leading to incorrect assessments and ambiguous conclusions. Also, the performance and the statistical design of the new control schemes should be evaluated under non-standard, more realistic, situations.Several procedures suitable for the monitoring of public health surveillance data have proposed and studied in the literature. However, further research is needed in the area. The basic aim of the proposed research is dual: (i) The development of improved monitoring procedures for attributes with specific applications in public-health surve
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'The Algorithmic and Neuronal Basis of Active Sensing in the Case of Odor-Trail Tracking'.

assistant: **Objectives**

In its natural environment, any behaving animal is constantly bombarded with sensory information that must be parsed quickly by the animal to act appropriately. Yet, the nervous system is limited in the amount of information it can handle. Thus, to avoid sensory overload, specific aspects of these information streams have to be actively attended to by the animal. Such focusing is called active sensing and is a fundamental operational mode of many sensory systems. One ethologically important model for active sensing that has received increasing attention is odor-guided navigation in rodents. During odor-trail tracking, sniffing rates rise up to four times above the normal respiration frequency and each sniff selectively determines which part of the external world is sampled. Yet, an algorithmic understanding of their search strategy as well as its neuronal basis is lacking. My aims are to understand the neural representation of odors during this natural behavior and to reveal the neuronal basis of odor tracking behavior by following a multidisciplinary research program. I will develop an experimental setup that can flexibly deliver tightly controlled odor trails on a custom-build treadmill. By generating specifically tailored odor stimuli, I will be able to probe odor-guided navigation in real time and thus uncover the tracking algorithm. Moreover, I will record neuronal population activity from the early olfactory areas in mice that are following the trail. Such population activity in behaving animals can now be measured because of recent developments in miniature microscopes and genetically encoded calcium probes. I will show which aspects of the stimulus and behavioral variables are encoded by applying feature selection methods. Furthermore, by linking the behavioral