RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Methodological Cosmopolitanism - In the Laboratory of Climate Change' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Climate change, framed in social scientific terms, offers a causal and moral narrative which connects, for example, users of electric toothbrushes in the USA and couples quarrelling about habits of consumption in Europe and Japan, with representatives disputing about a post-Kyoto agreement at global climate conferences, all the way to victims of flooding and draught events in Australia, China, India and Bangladesh. Even climate sceptics react to and thereby affirm the dominance of such a climate narrative. This coercive inclusion of the excluded ‘distant other’ is what I define as the social scientific fact of ‘cosmopolitization’ – in distinction from ‘cosmopolitanism’ as a philosophical norm.By taking climate change as a comprehensive case study experiment, this research project aims at reinventing the social sciences for the ‘age of cosmopolitization’. The ground-breaking nature of the project is to advance the present state of debate by validating the new theoretical, methodological and empirical tools needed for such a ‘cosmopolitan turn’.Since their inception in the late 19th century, the social sciences remain caught in a resilient methodological nationalism bound up with the presupposition that the national-territorial remains the primary container for the analysis of social, economic, political and cultural processes. Methodological nationalism is built into the basic concepts of modern sociology and political science, as well as into routines of data collection and analysis. Building on my previous work on methodological cosmopolitanism, this project undertakes a full-scale cosmopolitan case study of climate change, thereby rendering operative a new mode of transnational research cooperation, data generation, and theory validation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Effects of nutrient pollution on parrotfish in Mayotte : From physiological to microbial scales' under Horizon 2020.

assistant: **Concept**

Coral reefs are in precipitous decline worldwide due to a number of global stressors and local human impacts. Nutrient pollution emanating from sewage outfalls and coastal runoffs is often associated with the disruption of coral microbiomes, enhancing coral dysbiosis susceptibility that further alters coral health. That said, the mechanisms leading to microbial dysbiosis in reef organisms remain poorly understood. There is especially a need to investigate how nutrient pollution can affect the microbiomes of ecologically and economically important reef fishes such as parrotfishes, which are suggested to vector microbes to corals and enhance coral dysbiosis susceptibility when coupled with pollution. The proposed research will integrate approaches from microbial ecology and physiology to investigate to what extent nutrient pollution can alter parrotfish microbiomes, whether these changes result in differences in parrotfish physiology, and the potential cascading effects on coral microbiomes and health. Working with Dr. Villéger’s team at MARBEC, I will couple field collections from near pristine and polluted reefs in Mayotte with advanced tools in next-generation sequencing and ecology to test for nutrient-mediated changes to parrotfish mouth and gut microbiota. Both areas are known to serve vital physiological functions for fish and to host potential opportunistic bacterial taxa that could further alter health of both fish and corals. Through my secondment host with Dr. Sucré at the University Centre of Mayotte, I will acquire new skills in fish physiology that can be used to correlate physiological metrics (e.g. stress response) and microbial community status. Our findings may provide underappreciated pathways linking nutrient pollution to dysbiosis in parrotfish microb
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'How do tetraspanin proteins organize, shape, and remodel biological membranes?' (ReMembrane).

assistant: **Innovation**

Our bodies rely on protein driven shaping and remodelling of our cells’ membranes to function. Uncovering the mechanisms of remodelling of the cell membrane is, therefore, essential for understanding biological processes such as fertilization, but also to allow for precise intervention in them when needed. The interplay between protein position, membrane tension, and local curvature is believed to dictate these processes. However, experimental verifications of this hypothesis in specific biological systems are scarce. Here, I propose to apply my expertise in the characterization of mechanical properties and remodelling of membranes to obtain ground-breaking quantitative details of the shaping and remodelling mechanisms in which the Tetraspanin (TSPN) family of proteins are involved. TSPNs provide an ideal case study for several reasons, they are of extreme importance to biological processes such as viral infection, they are well characterized by biochemical, genetic and proteomics approaches, and their mode of action is suspected to depend on membrane tension and curvature. Of specific interest is the role of TSPN in the formation of the newly discovered cellular organelles, called migrasomes, which are a new cell-cell communication paradigm. This proposed project addresses TSPN functions by a bottom-up approach, reconstituting the processes of interest from simple building blocks and characterizing the distinguished roles of membrane tension and curvature. To this end we will use several new assays based on combined optical tweezers, micropipette aspiration and confocal microscopy as well as AFM that will operate on crafted membrane model systems. Our unique experimental approach will allow us to recreate the conditions leading to migrasome formation, egg-sperm, and vi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Protecting the rural poor against the economic consequences of major illness: a challenge for Asian transitional economies' (POVILL), addressing dissemination and exploitation.

assistant: **Impact**

Major illness in the family has become an important cause of household impoverishment in China and the ex-command economies of Southeast Asia, as these countries have managed the transition to a market economy. This is related to the low levels of governme nt funding of health care and the rising cost of medical care. The Governments of China and Cambodia have recently announced major policy initiatives to address this problem and the government of Laos is considering similar action. The purpose of this proj ect is to support these initiatives and assess their performance, whilst contributing to international knowledge about how to help households cope with major illness. The study will take place in rural areas in Cambodia, Laos and two provinces in Central C hina. In each location, the methodological approach will be that of in-depth case studies, organised as four integrated sub-projects. The first will assess the impact of different types of illness on different types of household and the effectiveness and c onsequences of the various coping strategies that they adopt.The second will assess the performance and outcome of health assistance schemes. The third will study how provider performance, particularly regarding use of drugs, contributes to the high cost o f care and identify realistic strategies for reducing these costs. The fourth will assess political and institutional influences on policy formulation and implementation. Each country team will produce-a consolidated report that includes recommendations ba sed on the findings of all the sub-studies. The project will be implemented in close communication with policy-makers and local government and NGO managers to ensure it contributes to policy and management practices. It will formulate and implement a disse m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Sex-dependent gene expression in human tissues' in the context of a Sixth Framework call.

assistant: **Objectives**

Are genes randomly located around the genome? Recent studies suggest not. Other data also suggest that sex chromosomes contain an unusual assembly of genes. In this project we want to study genes whose expression is sex biased, but not necessarily sex specific. Many hormonal, anatomical and behavioural differences exist in males and females. One expects that these differences in sexes arise from the differences in gene expression. Are these differentially expressed genes more or less prevalent on sex chromosomes? And might the sex biased gene expression be related to differential susceptibility to disease of the two sexes? It is well known that some diseases are more common in females than males and vice versa. Understanding the sex-specific differences in gene expression might also then be of great help for both diagnosis and treatment of diseases.There are only few large-scale analyses of the differential gene expression in male and female tissues and they are on organisms other than humans. There is great need for a comparative study of the gene expression in human males and females. We will approach this problem by analysing large amounts of human gene expression data, from normal as well as diseased tissues, which is collected in the numerous public databases. We will identify differentially expressed genes in the tissues from individuals of different sexes and analyse their distribution on different chromosomes. The sex dependent differential gene expression in normal and diseased tissue will be correlated with available disease statistics. This will be the first large scale comparative study of sex-dependent gene expression in human, which has application in genetics, physiology and medicine' s major research areas in Europe. The project will help in speeding up
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Improving resource efficiency through a protective film for hose reel irrigation' under Horizon 2020.

assistant: **Concept**

Hose reel irrigation systems are a type of sprinkler irrigation which is best used on irregular-shaped and difficult-to-reach areas. Although it is widely used, it presents some problems related to the high degree of friction between the hose carrying the water, and the ground. This fact implies larger labor force to move the hose, therefore provoking an inefficient use of resources (water and fuel); thus increasing fuel consumption and GHG emissions. This becomes particularly difficult at the time of rainy or muddy grounds by getting the hose stuck on the soil with no possibility to move and with the eventual broken of the hose or even the machine drive system. Moreover, the abrasion produced by the constant friction, deteriorates the hose, reducing its useful life. Irriland has over 24 years of experience in automatic hose reel irrigators, being one of the world leaders in the sector. In 2013, and based on the client’s feedback, Irriland started developing PROTECTOR, an absolutely novel, automated and easy to use accessory, based on a non-stick and water repellent protective film system placed between the ground and the hose. It allows to reduce hose friction (90% less) and protects hose from abrasion (doubling its life), transforming intensive irrigation by reducing operational costs (12% fuel savings), time (less irrigation cycles), and energy (10% less carbon emissions). Up to the date, several prototypes have been tested in different types of crops, reaching a TRL 6. Before entering the market, we need to optimize the final prototype, test it and validate it for a successful commercialisation. PROTECTOR was presented in the past November at Bolonia Machinery for Agriculture Fair with a big success, showing a clear market’s demand. End users will clearly benefit by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Restorative Effects of Haptic and Visual Sensory Supplementation of Nature Sounds in VR of Nature for Deaf people' (ReSens-Nature) targeting Horizon Europe.

assistant: **Abstract**

Exposure to nature and its sounds can relieve from stress, promote relaxation, and restore cognition. These restorative benefits persist even with exposure to Virtual Reality (VR) of nature and its calming sounds. It is the combination of visual and auditory exposure to these VR environments and their sounds that promotes restorative effects for hearing people. This means that Deaf and Hard-of-Hearing (HoH) people may be excluded from being able to receive the same restorative benefits that hearing people receive. Evidence shows that there can be cross-modal transfer in HoH people, whereby speech and sounds can be perceived and understood through vibrations on the skin or can be localised via visual cues in VR technologies. Through the ‘ReSens-Nature’ project, the Fellow will develop a novel VR experience, through which he will examine the restorative effects of vibrotactile and visual sensory supplementation of nature sounds in VR nature environments for Deaf/ HoH people. The objectives are to (i) Develop and establish the usability of this novel VR nature environment that uses vibrotactile and visual supplementation of nature sounds, (ii) Examine whether this novel VR nature environment is providing restorative benefits to Deaf/ HoH people in comparison to a regular VR nature environment without sensory supplementation and in comparison to hearing people. Understanding the effects of sensory supplementation for Deaf/ HoH in VR nature environments could help make VR and other technologies more inclusive for Deaf/ HoH people and people with other disabilities. The project will be completed at the GET Lab of Cyprus University of Technology, a world-leading lab on VR technology and Wellbeing. The Fellow will bring highly complementary expertise in Deafness, Audiology, and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Exoplanetary Systems with a Coronagraphic Archive Processing Engine' in the context of a Horizon Europe call.

assistant: **Objectives**

Determining the frequency of life in the Universe is one of the main challenges of the next decades. It requires a large high-contrast imager in space such as LUVOIR or HabEx, able to characterize dozens of nearby earth-like planets. The detection of such planets, 10^-10 fainter than their star and lost in the bright and varying glare of the star in the images, is a formidable challenge. In the race to remove the contaminating starlight, both the coronagraphic instrument and the image processing have a key role to play. Yet, the science and technological definition of these mission concepts relies entirely on the coronagraphic instrument to reject the starlight, assuming a simple gain of 10 in sensitivity with image processing based on 15-year-old techniques developed for HST. The cost of this approach is a daunting wavefront stability requirement of 20pm rms and conservative exoplanet yield estimates.With ESCAPE I propose to develop innovative image processing methods that make use of the specific hardware in these high-contrast imagers (their wavefront sensors and deformable mirrors) and of the data accumulated in their archives to bring a significant gain in starlight subtraction. I will use the unique opportunity of the timely launch of the Roman Space Telescope during the ERC timeframe, which precisely includes the CGI technology demonstrator of high-contrast imaging in space, to demonstrate my methods and achieve 20x improved detection limits. In parallel I will deploy the ESCAPE methods on the public archives of the VLT-SPHERE and JWST NIRCam and MIRI coronagraphic instruments to deliver higher-grade data to the community, obtain new planetary systems discoveries, and constrain the giant planet population on scales yet-unexplored and comparable to the Solar Syste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Eco-physiological tradeoffs with crop domestication: have farming ants cracked the code?' (ELEVATE) under Horizon 2020.

assistant: **Objectives**

Domesticated crops hardly resemble their wild ancestors, and often trade higher yield in artificially optimized conditions for lower performance in fluctuating environments. Leafcutter ants (genus Atta) provide fascinating parallels with human farmers, harvesting fresh vegetation used as compost to produce domesticated fungal crops that feed massive societies with millions of workers. However, while human agricultural systems are imperiled by rapid global changes, leafcutter ants have managed to grow one type of cultivar from Texas to Argentina, thriving across extreme rainfall and temperature gradients and across diverse climates over millions of years. However, the eco-physiological mechanisms governing this farming resiliency are poorly understood.I propose a new in vitro mapping paradigm to visualize the niche requirements of fungal cultivars. Creating multidimensional landscapes of nutrient availability (e.g. protein, carbohydrates, Na, P) and environmental stress (e.g. temperature, moisture, plant toxins, crop pathogens) I will answer three main questions:1)What genes and biochemical pathways shape cultivar performance across interacting gradients of nutrition and stress? 2)Do colonies harvest substrates to navigate nutritional contours of cultivar performance maps and avoid production tradeoffs?3)Do locally adaptive cultivar traits shape the performance of farming societies across regional ecological gradients, and over 60 million years of co-evolutionary crop domestication by farming ants?My cutting-edge approach will deliver transformative advances to the field of eco-physiology, enabling seamless integration between field and laboratory experiments, and providing new ways to visualize evolutionary mechanisms across levels of biological organization from genes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Connecting the dots going backwards: An epigenetic memory recorder to trace ancestry during mouse gastrulation.'.

assistant: **Innovation**

During development, a cell's fate will become increasingly restricted, facilitated by the combined activity of transcription factors and epigenetic modifiers. Single-cell RNA sequencing has greatly improved our appreciation of the transcriptional dynamics underlying lineage specification. However, we still do not fully comprehend how epigenetic modifiers guide this highly dynamic process, as methods that enable us to accurately concatenate a cell's past and present epigenetic state with its current lineage identity are missing.Here, I propose to investigate the combined dynamics and interdependencies of transcription and the polycomb-group of proteins during the differentiation of mouse embryonic stem cells into gastruloids. First, I aim to deploy a protocol that enables the simultaneous quantification of both layers in the same single cell to disentangle epigenetic from transcriptional heterogeneity. Second, I aim to develop a molecular memory system to record the past epigenetic profiles of single cells. This system will be based on the expression of proteins fused to a bacterial Dcm methylase, which will allow for the timed recording and faithful transmission of historic epigenetic profiles. Combined with quantification of transcription of the same single cell, this will enable us to directly integrate past epigenetic states with the current identity of single cells.The proposed work here will therefore allow us to directly assess the role of epigenetic modifiers on establishing cell fate choice and will have important implications on our understanding of the regulation of mammalian development.


**Keywords:** Development ,  Epigenetics ,  Single-cell ,  Gastruloids ,  Memory