RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'ATOMIC-scale foundation of a Physics-based Interface Engineering in crystalline materials'.

assistant: **Objectives**

Inorganic materials are integral to numerous fields, including transportation, electronics, and medical applications. Understanding their mechanical properties, particularly permanent inelastic deformation, has been a central pursuit in material science. My project, AtomicPIE, focuses on uncovering the key mechanisms driving plasticity in metallic alloys, emphasizing dislocation-interface interactions. These interactions occur at grain boundaries and phase boundaries, which significantly influence material strength, reliability, and lightweight properties. Despite extensive studies, a comprehensive understanding of slip transfer—how dislocations propagate across interfaces—remains elusive. AtomicPIE integrates atomistic simulations, generative machine learning models, and enhanced discrete dislocation dynamics to address this gap. By simulating crystalline defects and their interactions, the project employs Nye dislocation densities to bridge atomic- to micro-scale modeling. A key innovation is the use of machine learning to predict complex Nye dislocation fields for mesoscale simulations. The framework developed within AtomicPIE will be validated through experiments and cross-scale molecular dynamics, focusing on ultra-fine-grain aluminum alloys. AtomicPIE aims to establish a physics-based understanding of slip transfer at interfaces, paving the way for advanced materials design and interface engineering.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'the Onset of Prebiotic chEmistry iN Space'.

assistant: **Concept**

The question of the origin of life has intrigued human beings for centuries. Life appeared on Earth about 3.8 billion years ago, but we ignore the process that made it possible. Recent theories propose that primitive Earth was a huge chemical reactor where a high diversity of precursor components progressively turned into primordial metabolic, self-replicating, and membrane-bounded systems. The origin of these components is debated. They could be formed endogenously or exogenously. It is remarkable that life appeared on Earth soon after the arrival of tones of extraterrestrial organic material on its surface by the impact of meteorites and comets and thus, exogenous delivery is considered a decisive step in the origin of life. This idea is supported by the detection of amino acids, nucleobases and sugars in meteorites and comets. It has been proposed that the chemical composition of comets could be inherited from the parental, interstellar molecular cloud core. But what molecules of prebiotic interest can be formed in interstellar space? And which ones could be inherited from the initial conditions of star and planet formation?OPENS is an interdisciplinary project that will discover what prebiotic molecules are present in the interstellar medium (ISM) and are inherited by Solar-system precursors. Our novel approach integrates astronomical observations, laboratory experiments of ices, quantum chemical computations and theoretical modeling. This project is very timely since it will exploit ultra-sensitive, broadband spectral surveys recently obtained with IRAM 30m and Yebes 40m, and data from ALMA and JVLA large programs and from a JWST ERS project. The detection in the ISM of the prebiotic compounds essential for the emergence of life, will pave the way for future labora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Creating and testing a method for controlling the air quality based on a new biotechnological tool. Use of a devitalized moss clone as passive contaminant sensor' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The European Council Directive 96/62/EC about ambient air quality assessment and management, requires to States the periodical availability of information about air quality within their territories. Nevertheless, the available methods are expensive, which prevents they can be used in a large scale. Thus, at present it is necessary to have inexpensive and robust tools for monitoring air quality across Europe. The use of mosses, due to its high efficiency in the load of both particulate and gaseous forms of organic pollutants, inorganic and radioactive, may be an optimal choice. Until now they are used as biomonitors of air quality, but recently several investigators have realized the benefits of using devitalized mosses, because it allows disposing transplants in well defined initial conditions. This really leaves the field of biomonitoring, as the material is used dead, and approximates to the setup of a new biotechnological tool. Actually biotechnological techniques allow cultivating mosses in bioreactors, so it  is possible to isolate a moss clone, to cultivate it and to produce a standard material (potentially patentable) which would be comparable to the use of resins or polymers for atmospheric quality control -mosses behave as pollutant exchange resins and their use as filters has been considered for decades. For these reasons we propose the implementation of a project having as main contents: 1) selection and culture of a moss clone; 2) characterization -molecular, physical, physical-chemical and multi-elemental- of the cultivated clone; 3) large-scale production of moss-bags for transplants; 4) comparison between the data collected using moss-bags and traditional techniques (i.e. bulk deposition collectors, particles samplers and gaseous samplers) to allow tool v
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Engineered plant-derived extracellular vesicles tagged with magnetic nanoparticles as novel antitumoral agents' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In recent decades, extracellular vesicles (EVs) have emerged as promising therapeutics in biomedicine due to their crucial role in intercellular communication and their capacity to deliver biomolecules such as proteins, lipids, and RNAs to recipient cells. Despite their potential, EVs derived from mammalian sources face several challenges, including safety concerns, high production costs, and inconsistent reproducibility. Plant-derived EVs, however, present a safer and more effective alternative, thanks to their non-toxic nature, lack of immunogenicity, and unique molecular biocargo. The EMERGE project aims to create innovative hybrid nanomaterials for cancer treatment by combining plant-EVs with magnetic nanoparticles (MNPs). This novel approach not only exploit the inherent safety and therapeutic potential of plant-EVs but also addresses production challenges by employing plant cell cultures (PCCs) as biofactories for EV production. MNPs will serve a dual purpose: they will facilitate the selective purification of EVs from PCC-conditioned media and enhance their anticancer effects through magnetic hyperthermia (MHT). The project will focus on refining EV purification and functionalization, optimizing the loading of anticancer agents, and assessing the effectiveness of MNP@eEVs in both traditional 2D cancer cell models and advanced 3D patient-derived tumor organoids (tumoroids). Tumoroids, as advanced models derived from patient samples, offer a cutting-edge approach to personalized medicine, providing more precise testing environments for therapeutic strategies. By integrating plant-derived EVs with MNPs and utilizing MHT, EMERGE aims to push the boundaries of drug delivery systems and enhance cancer treatment outcomes, marking a significant advancement in the field o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for '6G TERrestrial & non-teRrestrial integration through an AI-Native architecture' to be submitted under Horizon Europe.

assistant: **Abstract**

6G is expected to trigger a total rethink of network architecture design, adopting the new Network of Networks vision which promotes the integration of multi-stakeholder, multi-technology infrastructures. To this end, future 6G systems will tightly integrate upcoming satellite systems and Low-Earth Orbit constellations (e.g., OneWeb) as well as High-Altitude Platforms (HAPs) and unmanned aerial vehicles (UAVs), a concept termed as integrated Terrestrial and Non-terrestrial Networking (TNTN). However, the sheer scale and heterogeneity of future TNTN infrastructures is expected to create a unique set of challenges. To this end, 6G-TERRAIN adopts Integrated Communication and Sensing (ICAS) as a key enabler of TNTNs, allowing to perceive the complex and dynamic TNTNs through sensing the physical environment. Moreover, 6G-TERRAIN aims to propose, design, and validate a novel Native AI automation architecture and its associated enabling technologies and theoretical frameworks, aiming for an intent 6G System with seamlessly integrated multi-stakeholder & multi-technology (e.g., terrestrial and non-terrestrial) nodes. Natural Language intents are adopted, exploiting the breakthrough capabilities of emerging LLMs to automatically plan the optimal decompositions of intents into tasks and prioritise their downstream execution. Finally, 6G-TERRAIN will build a training network to conduct top-notch research towards the development and experimental evaluation of a gamut of techniques, methodological frameworks and tools that will break the barriers currently impeding the realisation of the 6G “Network of Networks” vision.


**Keywords:** 6G, Zero-Touch, Native AI, ICAS, NTN, IBN, LLMs, Generative AI
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New tools to improve clusters key European Technology Transfer' in the context of a Sixth Framework call.

assistant: **Objectives**

Both Cluster initiatives and Technology Transfer are important part of European, national and regional policy to increase competitiveness of economy. IRC network is recognized as a good tool to increase trans-national technology partnership between companies in Europe but the number of TT partnership is still to low according to the effort engaged by IRCs. As a group of 6 IRC organisations from six different regions (hone-Alpes. Bourgogne, Lombardi, Greece, Baden-Wurttemberg and Belgium), the NEWTICKETT partners are among the most experienced IRCs in TT and their regions all have cluster initiatives. As clusters are community of research organisations, big companies, SMEs and Start-ups all focussed on technological innovation, they are a good target to develop and test new methodology to reach a better productivity of TT organisations. NEWTICKETT aims at developing a TTT aproach which is based on four mains points: -Cluster members as targeted population with both individual and collective approach -Proact ive approach based on working on all the innovation value chain from market to research taking in account innovation strategy and project of companies -Produce 120 TT company innovation plans which integer TT as strong way to increase competitiveness-Us e regional, National, European and international networks and events to disseminate cooperation opportunities and implement partnership, Cluster organisations and IRC thematic groups will be involved in the project to give their inputs in methodology and results assessments. Beyond the methodology, NEWTICKETT will also contribute to increase networking between European TT networks and European clusters. NEWTICKETT will also promote and disseminate the new methodology to all IRCs and cluster organisations in order to im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Synthesis of systematic resources' (2014-2020).

assistant: **Innovation**

European natural history collections are a critical infrastructure for meeting the most important challenge humans face over the next 30 years – mapping a sustainable future for ourselves and the natural systems on which we depend – and for answering fundamental scientific questions about ecological, evolutionary, and geological processes. Since 2004 SYNTHESYS has been an essential instrument supporting this community, underpinning new ways to access and exploit collections, harmonising policy and providing significant new insights for thousands of researchers, while fostering the development of new approaches to face urgent societal challenges. SYNTHESYS+ is a fourth iteration of this programme, and represents a step change in evolution of this community. For the first time SYNTHESYS+ brings together the European branches of the global natural science organisations (GBIF, TDWG, GGBN and CETAF) with an unprecedented number of collections, to integrate, innovate and internationalise our efforts within the global scientific collections community. Major new developments addressed by SYNTHESYS+ include the delivery of a new virtual access programme, providing digitisation on demand services to a significantly expanded user community; the construction of a European Loans and Visits System (ELViS) providing, for the first time, a unified gateway to accessing digital, physical and molecular collections; and a new data processing platform (the Specimen Data Refinery), applying cutting edge artificial intelligence to dramatically speed up the digital mobilisation of natural history collections. The activities of SYNTHESYS+ form a critical dependency for DiSSCo - the Distributed System of Scientific Collections, which is the European collection communities ESFRI initiative. DiSSC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Inequality in work, wealth, and welfare' (I3W).

assistant: **Innovation**

I3W aims at generating empirical knowledge and novel theories to explain the joint distribution of work, wealth, and welfare in the population using macroeconomic theory, structural quantitative models, and micro data. Specifically, I3W’s overall goal will be achieved through the following research objectives and their corresponding work packages (WP):I. Develop a macroeconomic framework of the drivers of welfare inequality.  In WP1 I will develop a model based on expected utility—a function of lifetime consumption, lifetime leisure, and life expectancy and their joint distributions—for measuring inequality in economic well-being within a country using rich longitudinal datasets. This framework will allow me to measure and decompose the welfare inequality in a selection of European countries and compare to the US over time, allowing a deeper understanding of the observed heterogeneity in the population along various dimensions: life expectancy, hours worked, wealth, income, consumption, and ultimately also welfare. II. Analyze underlying factors affecting the drivers: the case of inequality of leisure in relation to access to insurance. In WP2 I will test the hypothesis that better insurance, interpreted in its most general form, leads to a more positive correlation between wages and hours worked. I will base my arguments on observations from micro data, show it theoretically using a theory of labor supply that is consistent with cross-country evidence, evidence over time, and evidence from micro data, and quantify the importance in practice with a carefully calibrated heterogenous-agent model. The outputs of WP1 and WP2 will be two working papers that will push the current boundaries of the welfare inequality research field while providing policymakers a tool box for t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Control of translation efficiency in proliferating and differentiated mammalian cells'.

assistant: **Concept**

Translation maps the transcriptome onto the proteome. It is regulated at the initiation levels and also by mRNA secondary structure, and – our current focus – by the interplay between the mRNA and tRNA pools. Although a lot is known about the mechanics of translation, its effects on physiology, particularly on proliferation and differentiation in mammals presents major open questions.tRNAProlif offers an approach that consists of genome-wide measurements and analyses of the tRNA and mRNAs pools, and the interplay between them, in proliferative and differentiated cells. The project will explain how changes in translation affect, and are affected by, these two states.We rely on our preliminary results that show a striking dichotomy in codon usage: genes involved in cellular proliferation have distinct codon usage compared to genes involved in differentiation and other multi-cellular process. Further, the tRNA pool consists of two distinct sub-populations: tRNAs whose codons are enriched among the proliferation genes are induced in proliferation and cancer, and tRNAs whose codons are enriched in differentiation genes are repressed in proliferation and are induced in differentiation. Towards understanding this “tRNA Switch” we aim at:Causality: We will determine whether the tRNA pool affects the proliferation/differentiation status of cell. Conversely, we will determine the effects of the proliferation/differentiation status on the tRNA pool.Regulation: We will establish the regulatory scheme that governs the “tRNA Switch”: we will determine the effects of transcriptional and post-transcriptional regulation on the tRNAs, depending on cell state. We will determine how the balance between the two tRNA sub-populations affects the proteome.Evolution: We will conduct comparative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multiscale Fluid-Solid Interaction in Heterogeneous Materials and Interfaces' (MULTISCALEFSI) under Seventh Framework.

assistant: **Objectives**

Fluid-solid interaction (FSI) governs nature.  From soft tissue modeling to lubrication technology, FSI problems in biomechanics and engineering are a major challenge in computational science towards understanding and emulating nature.  This challenge is further intensified by the multiscale structure of materials and interfaces as well as by the finite configurational change (FCC) that a microstructure experiences under large deformations.The goal of this proposal is to conduct fundamental research on novel computational strategies for the modeling and analysis of multiscale FSI for materials and interfaces with FCC on all scales and homogenization as the core scale transition technique.  The examples that will motivate and guide this research are potential future biological and industrial applications of the novel computational framework: (1) soft porous materials such as tissue scaffolds and articular cartilage that function together with pore-level fluids in order to facilitate organ regeneration and provide mechanical support, and (2) rough or textured compliant interfaces as in bearings and polymeric seals that deliver enhanced lubrication performance by increasing load-carrying capacity and decreasing energy consumption.The theoretical and computational basis of the envisioned research spans techniques from continuum and statistical mechanics.  If successful, the major benefits of this research will be (i) a robust continuum FSI scheme based on the numerically efficient lattice Boltzmann method for the fluid coupled to the finite element method for the solid, which will constitute the basis of (ii) novel homogenization techniques that deliver a non-phenomenological description of advanced anisotropic porous media and lubrication theories, and which will ultimatel