RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Biophotonic Spectroscopic tool for Helicobacter Pylori diagnosis - a pathway for low cost clinical robotic device' (2014-2020) under Horizon 2020.

assistant: **Objectives**

Gastric Cancer (GC) is the fifth most common malignancy in the world. Being the third leading cause of death, it claimed 723,000 lives worldwide in 2012, 12 lives/day in the UK (2014-2016), 29 lives/day in U.S. in 2018 and 6th most common in Europe. With such high number of deaths, it can be compared to no less than an epidemic disease. According to International Agency for Research on Cancer, 89% of all GC cases are attributed to infection from Helicobacter Pylori (Hp). H. pylori produces an enzyme called urease which causes creation of an alkaline buffer zone which keeps it safe from gastric acid and silences the immune system of stomach against this microbe. This result in formation of gastric ulcer which grows into cancerous tumour. Early diagnosis of H. pylori is important for understanding pathology of gastric cancer and starting early therapy. But high cost, ambiguous diagnosis and poor patient engagement of existing diagnostic methods leads to late/advanced stage diagnosis of cancer. Patients spend $700-$1800 for standard 2 week triple drug therapy. Such high cost in low and middle income country (LMIC) is a burden where 33 million individual face catastrophic health expense & cancer take their toll at the cost of human life. This cost can further increase with late diagnosis. H. Pylori-Scopy aims to reduce the cost by performing early diagnosis with single stop, easily accessible, portable, unambiguous, instantaneous screening device, which results in increased patient engagement with no waiting for medical reports and quick medication. H. Pylori-Scopy is a combination of light based Raman/Fourier Transform Infrared, & Chitosan-Magnetic-Swob spectroscopy, which offer an unambiguous addendum tool for h-pylori diagnosis using standard endoscopy, suitable not only
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Combining Single Molecule and Ensemble approaches To Investigate Cas9 Target Search' (CasMETICS), addressing dissemination and exploitation.

assistant: **Impact**

The CRISPR-Cas9 bacterial immune system has garnered intense interest both as a synthetic biology tool and as a biological system in its own right. Yet the ability of Cas9 to find its guide-RNA-directed binding site in a timely fashion remains mysterious. To find its binding site, the single-stranded guide RNA must recognize the appropriate homologous DNA target within double-stranded chromosomal DNA, without using ATP to melt dsDNA. Moreover, in vitro measurements of Cas9 target search seem to suggest that an individual Cas9 molecule should take on the order of months to discover its target site, far too long to defend against viral infections which can proceed to lysis in less than one hour. To begin to unravel these conundrums, I plan to measure Cas9 target search time in vivo, using both single molecule and bulk approaches. The single molecule assay will use fluorescently tagged dCas9 (a version of Cas9 non-functional for cleavage) targeted against the lac O1 binding site. At t=0 the synthetic inducer IPTG can be flowed in, dissociating LacI from the O1 binding site, and the amount of time needed for dCas9 to bind determined by time-lapse fluorescence microscopy. The bulk version of the assay will exploit the existence of a binding site for the restriction enzyme BsrBI in the lacO1 binding site. As in the single molecule assay, the clock is started by addition of IPTG to growing cells, and the time needed for dCas9 binding is quantified by observed how long is needed for dCas9 to confer protection against BsrBI cleavage of cross-linked and purified chromatin. Finally, I will perform high-speed tracking experiments on searching dCas9 molecules using electroporated fluorescent dye-labeled guide RNAs. These measurements should constrain mechanistic hypotheses about Cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'DIACHRON – Managing the Evolution and Preservation of the Data Web' (DIACHRON).

assistant: **Concept**

The Web has not only caused a revolution in communication; it also has completely changed the way we gather and use data. Open data -- data that is available to everyone -- is exponentially growing, and it has completely transformed the way we now conduct any kind of research or scholarship; it has changed the scientific method. The recent development of Linked Open Data has only increased the possibilities for exploiting public data.Given the value of open data how do we preserve it for future use? Currently, much of the data we use, e.g. demographic records, clinical statistics, personal and enterprise data as well as many scientific measurements cannot be reproduced. However, there is overwhelming evidence that we should keep such data where it is technically and economically feasible to do so. Until now this problem has been approached by keeping this information in fixed data sets and using extensions to the standard methods of disseminating and archiving traditional (paper) artifacts. Given the complexity, the interlinking and the dynamic nature of current data, especially Linked Open Data, radically new methods are needed.DIACHRON tackles this problem with a fundamental assumption: that the processes of publishing and preservation data are one and the same. Data are archived at the point of creation and archiving and dissemination are synonymous. DIACHRON takes on the challenges of evolution, archiving, provenance, annotation, citation, and data quality in the context of Linked Open Data and modern database systems. DIACHRON intends to automate the collection of metadata, provenance and all forms of contextual information so that data are accessible and usable at the point of creation and remain so indefinitely.The results of DIACHRON are evaluated in three large
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Artificial Intelligence methods for Underwater target Tracking' under Horizon 2020.

assistant: **Concept**

The Artificial Intelligence methods for Underwater target Tracking (AIforUTracking) project will bring to the scientific community new tools for underwater target tracking by Autonomous Underwater Vehicles (AUVs) using Reinforcement Learning (RL) techniques. Moving towards the envisioned applications of marine animal tracking by autonomous vehicles, this proposal is clearly at the forefront of research, and directly addresses some of the main challenges and needs of the last Marine Strategy Framework Directive of the European parliament and of the Council, in particular establishing a framework for community action in the field of marine environmental policy. This research project will directly contribute to maintain and improve the health of the ocean by establishing innovative and unique research collaborations, and by introducing novel concepts and original research strategies that could provoke breakthroughs in the field of marine animal behavioural studies by:a) Designing and developing optimisation algorithms that leverage new RL approaches, such as Partially Observable Markov Decision Process (POMDP) and Multi-Agent Reinforcement Learning (MARL). These Artificial Intelligence (AI) tools will increase the autonomy of the AUVs while improving the accuracy of the estimated target position.b) Demonstrating the effectiveness and application of the path optimisation technique using POMPD and MARL methods by conducting real tests in the ocean, i.e. different targets will be tracked using a single AUV or multiple AUVs, as a proof-of-concept. These innovative technologies, together with Range-Only and Single-Beacon (ROSB) and Area-Only Target Tracking (AOTT) methods, are more competitive and offers greater autonomy than the traditional Long BaseLine (LBL) arrays-based met
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'HB-086 and HB-097 for Treatment of Chronic Sensory Neuronal Disorders - Neuropathic Pain and Hearing Loss' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

HB-086 and HB-097 comprise our portfolio of therapeutic proteins. They are a family of growth factors with actions on sensory nerve cells and represent a novel treatment approaches and a paradigm shift for medical treatment and prevention of severe, chronic conditions as pain and hearing loss. The drug candidates target sensory nerve cells and their support cells in dorsal root ganglia and inner ear. Evidence indicate a mode of action including normalisation of impaired neuronal-glial crosstalk, protection, and regeneration of sensory nerve fibres. All key biological mechanisms underpinning increased peripheral afferent drive associated with chronic pain, and apoptotic hearing loss. Preclinical data confirm that HB-086 completely abolishes pain sensation across different models and HB-097 preserves the sense of hearing in relevant models. Importantly, documented prolonged effects warrant biweekly or monthly dosing and prevention of further disease progression.


**Keywords:** Health-related biotechnology,Clinical medicine,Neuropathic pain,Hearing loss,Sensory neuronal dysfunction
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Homo Mimeticus: Theory and Criticism'.

assistant: **Innovation**

Mimesis is one of the most influential concepts in Western thought. Originally invoked to define humans as the “most imitative” creatures in classical antiquity, mimesis (imitation) has recently been at the centre of theoretical debates in the humanities, social sciences, and the neurosciences concerning the role of “mimicry,” “identification,” “contagion,” and “mirror neurons” in the formation of subjectivity. And yet, despite the growing confirmations that imitation is constitutive of human behaviour, mimesis still tends to be confined to the sphere of realistic representation. The HOM project combines approaches that are usually split in different areas of disciplinary specialization to provide a correction to this tendency.Conceived as a trilogy situated at the crossroads between literary criticism, cinema studies, and critical theory, HOM’s outcomes will result in two monographs and accompanying articles that explore the aesthetic, affective, and conceptual implications of the mimetic faculty. The first, radically reframes a major proponent of anti-mimetic aesthetics in modern literature, Oscar Wilde, by looking back to the classical foundations of theatrical mimesis that inform his corpus; the second considers the material effects of virtual simulation by looking ahead to new digital media via contemporary science-fiction films; and the third establishes an interdisciplinary dialogue between philosophical accounts of mimesis and recent discoveries in the neurosciences. Together, these new perspectives on homo mimeticus reconsider the aesthetic foundations of a major literary author, open up a new line of inquiry in film studies, and steer philosophical debates on mimesis in new interdisciplinary directions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'The anatomy and dynamics of the cortical processing of naturalistic sounds'.

assistant: **Innovation**

Sensory systems evolve to allow organisms to know the environment. Psychophysics research of everyday naturalistic sounds shows that audition enables us to get to know the objects in the environment, sound sources, based on the processing of multiple types of sound-related information. This project aims to integrate psychophysics and cognitive neuroscience methods in order to clarify: [Study1] what information drives the cortical processing of everyday naturalistic sounds; [S2] how cortical processes enable us to recognize sound sources. Each of these questions will be addressed within one multimodal fMRI/MEG study.[S1] Studies of the cortical encoding of naturalistic sounds reveal a widespread sensitivity for sound categories. It is unclear the extent to which this sensitivity is mediated by systematic between-category differences in low-level acoustical structure and in higher-level semantic factors. We aim to clarify this issue within a study of highly diverse naturalistic sounds.[S2] Previous cognitive neuroscience studies revealed cortical regions sensitive to the properties of the sound source (e.g., object size) or to its identity (e.g., speaker). The relationship between the cortical processing of source properties and identity is unclear, and the extent to which general cortical mechanisms mediate the representation of highly diverse sound sources is largely unknown. We aim to clarify these issues within a study of vocalizations and impacted-object sounds.We will measure stimulus-information encoding in both activation- and pattern-based measures of the cortical activity (average BOLD vs. spatial BOLD distribution in a cortical volume; power vs. temporal pattern of windowed timecourse of MEG source). Results will answer open scientific questions and characteriz
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Promoting & implementing joint programming to reinforce transnational research for the conservation and restoration of degraded ecosystems and their biodiversity, including a focus on aquatic systems' to be submitted under Horizon 2020.

assistant: **Abstract**

Many of the European and world's ecosystems undergo degradation of terrestrial, aquatic and transitional ecosystems with nMany of the European and world's ecosystems undergo degradation of terrestrial, aquatic and transitional ecosystems with negative impacts on biological diversity and people’s livelihoods. In this context, research actions are needed to ensure the protection and/or restoration of ecosystems and their biodiversity whilst meeting the socio-economic, political and cultural needs of current and future generations. By networking 34 funding agencies from 27 countries from Europe & other continents, BiodivRestore aims to promote coordinated international research on conservation and restoration of degraded ecosystems and their biodiversity, in all environments, including a focus on aquatic systems. It will strengthen research & research programmes coordination to support science-based evidence for the implementation of a relatively wide range of European and International policy initiatives and therefore act for better management, conservation and restoration of ecosystems and their biodiversity. This will notably be achieved by launching one call for proposals co-funded by the European Commission, as well as a knowledge hub to support the implementation of nature restoration policies, promoting research collaboration across national borders & disciplines and supporting dialogue & collaboration between academia & stakeholders, and stakeholder engagement in research in order to increase the impact of research on policy & practice. BiodivRestore will also contribute to networking, clustering and capacity building activities for the research community in the field and enhanced synergy coordination between RDI funding programmes (national, EU, International) in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'QUIetening the Environment for a Sustainable Surface Transport' to be submitted under Seventh Framework.

assistant: **Abstract**

Noise Reducing Devices (barriers, claddings, covers and added devices following EN14388) play an important role in noise reduction: optimizing their global performance is of major concern towards Sustainable Surface Transport. QUIESST will merge, for the very first time and within a true holistic approach, “true” intrinsic products characteristics, whatever their materials and shapes, together with their extrinsic ones, in order to assess their actual global capacities to reduce the amount of people exposed to noise (END target). It will address 5 main topics: NEAR / FAR FIELD RELATIONSHIP: linking the intrinsic characteristics to the corresponding extrinsic far field effect; IN-SITU MEASUREMENT METHODS: developing methods relevant of the actual intended use, allowing long term performances control; COMPARING NRD’s PERFORMANCES with different test methods: building a database comparing both existing and new tests results and providing the relevant relationship; OPTIMIZING NRD’s GLOBAL PERFORMANCE through a HOLISTIC APPROACH: considering acoustic, non acoustic and global impact optimization, multicriteria optimization strategies, and possible global performance indicators; SUSTAINABILITY: defining the relevant generic criteria and developing the first existing NRD’s overall sustainability assessment method. The final verifiable result will be the ACTUAL USE of the “Guidebook to NRD optimisation” as a reference tool for noise mitigation. QUIESST addresses the call as it concerns surface transport noise abatement (road AND rail), considers cost benefit analysis and addresses the END objectives, covers true holistic noise abatement solutions through wave propagation and systems for passive compensation. Its team, made of 14 partners from 9 countries integrates the relevant
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Virtual Observatory Infrastructure for Earth Observation Data' under Seventh Framework.

assistant: **Concept**

Earth observation data have increased considerably over the last decades with satellite sensors collecting and transmitting back to Earth several terabytes of data per day. This data acquisition rate is a major challenge to existing data management, exploitation and dissemination approaches used by various agencies such as ESA, NASA and European national space agencies. The availability of earth observation data now outstrips the availability of human intelligence to exploit it.<br/>To make the available petabytes of EO data easily accessible by an even larger group of end user applications, the proposed project will design and implement a Virtual Observatory infrastructure for EO data. The Virtual Observatory will use state-of-the art scalable DBMS technology to store and query raw image data, image metadata and symbolic representations of images capturing their content and its semantics. We will develop efficient algorithms to integrate images with relevant geospatial data sets, and to discover knowledge which currently lies dormant in EO archives. Because satellite instruments transmit data continuously, we will pay special attention to the streaming nature of EO data and will make significant contributions to querying streams of EO images and relevant geospatial data sets.<br/>Our advances to the state of the art are demonstrated in two use cases: A Virtual Observatory for TerraSAR-X data" and "Real-time fire monitoring based on continuous acquisitions of satellite images in combination with geospatial data".<br/>With the support of the European Space Agency, EO scientists will be involved in our project throughout its entire life-time, from requirements definition, through development to testing and validation, thus making sure that the our results have a lasting i