RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structure, maturation and cell entry mechanisms of ranavirus virions' in the context of a Seventh Framework call.

assistant: **Objectives**

The long-term goal of this proposal is to understand the molecular mechanisms of the replication cycle ofnucleocytoplasmic large DNA viruses that attracted attention after the discovery of the giant Mimivirus adecade ago. Here, we focus on ranaviruses from the family Iridoviridae that have caused large economiclosses in Europe and Asia and threaten wildlife biodiversity worldwide. The ranavirus disease has thereforebeen listed by the World Organization for Animal Health. Ranaviruses have a unique replication cycle thatleads to two coexisting forms of infectious particles, naked capsids and enveloped virions, each withdifferent mechanisms of cell egress and cell entry. Additionally, the proteinaceous capsid contains aninternal membrane that presumably assists to assembly of a large DNA-free icosahedral shell. This shellis subsequently filled by the viral genome and transforms into the mature capsid by a headful packaging mechanism that is also used by some dsDNA bacteriophages. We aim to characterize the structural and mechanistic features of ranavirusassembly, maturation and cell entry by combination of cryo-electron microscopy and tomography with othercomplementary techniques. The novelty in our plan is application of cryo-FIB micromachining and cryo-electrontomography to visualize the intracellular steps of the ranavirus replication cycle in 3D at nativeconditions. The three objectives of this research project are to: (i) identify the structural basis of subunitrecognition that guides assembly of large icosahedral capsids of type ranaviruses and elucidate the functionof the internal membrane in this process, (ii) determine the conformational changes that accompanymaturation of ranavirus capsids and regulate the headful packaging of the dsDNA genome, and (iii) ascertai
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Effect of Adding H2, CO, CO2 and H2O to Premixed Hydrocarbon Flames - Numerical Characterization and Modelling' (EAP-FLAME).

assistant: **Concept**

In order to meet the EU targets on renewable energy and greenhouse gas emissions, there is an urgent need to increase the use of renewable fuels such as syngas and biogas. In the mean time, the low efficiency and emission problems associated with non-premixed combustion systems are also driving the move away from such systems towards lean premixed combustion where fuel is mixed with excess air prior to combustion. Despite substantial progress achieved in turbulent combustion, there still lacks the understanding of the following four phenomena in the context of premixed mode: (i) development of flames (ii) influence of high-pressure on turbulent burning velocities, (iii) preferential diffusion effects which are most pronounced in mixtures that contain free hydrogen, and (iv) flame quenching by very intense turbulence is still poor and is the main fundamental challenge to premixed combustion science and technology. The project is aimed at numerically characterizing the burning behaviour of premixed hydrocarbon flames diluted by the addition of H2 CO2, H2O and CO and developing high fidelity modelling techniques to facilitate the study and design of practical combustion systems involving such flames. The main objectives are: 1) To carry out numerical investigations using the large-eddy simulation techniques on the aforementioned three important phenomena, i.e. (i) development of hydrogen blended premixed flames (ii) influence of high-pressure on turbulent burning velocities, (iii) preferential diffusion effects; 2) To develop a turbulent reacting flow model accommodating above first three phenomena, 3) To validate the numerical mdoel by using: experimental data of Gökalp’s group on lean H2/CH4/air turbulent Bunsen flames at various pressures up to 9 bar, the PSI group in S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Bio-engineering by atmospheric plasma treatment' under Sixth Framework.

assistant: **Concept**

The objective of this proposal is to develop an entirely new, one-step process for the immobilization of proteins/enzymes or other biomolecules of interest, which is applicable on a large scale to surfaces of any kind. If successful, the new methodology wi ll offer several advantages over the classical immobilization techniques, including a better reproducibility, high flexibility, broad applicability, straightforward processing and thus potentially high throughput rates. The new way of processing may in tur n lead to entirely new applications which are not feasible with the current state-of-the-art technology. The method of immobilization to be investigated exists in the incorporation of biomolecules, and proteins in particular, in thin plasma polymerized coa tings. For that purpose, solutions containing these proteins or other biomolecules will be administered to a cold, atmospheric plasma together with either liquid or gaseous polymer precursors. Biomolecules may then be incorporated into very thin plasma pol ymer films and exposed to the surface where they exhibit their activity, providing they are not damaged by the plasma. The effect of the plasma on the structure and activity of biomolecules is largely unknown and it represents the main research topic of th is project. The bio-engineered materials to be obtained are envisioned to have bio-recognition sites, designed to specifically interact with other biological or non-biological species. Applications of such materials can be found in the medical, chemical, e nvironmental, food, materials and many other industrial sectors, including but not limited to bio-sensors, labs-on-a-chip, bio-mimetic materials, anti-microbial materials, intelligent materials, etc. In order to optimize the chances of success of this proj e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Exploring the Cosmological Origins of the Cosmic near Infrared Background Fluctuations' to be submitted under Seventh Framework.

assistant: **Abstract**

The emergence of the first stars and black holes in the early Universe ranks highly on Europe's list of research priorities and is driving the construction of powerful telescopes. While the first light objects will remain largely inaccessible to individual detections with future telescopes, they may be detectable via their recognizable contribution to the Cosmic near Infrared Background (CIB) fluctuations. This signal is now well established by current instruments and is emerging as a crucial tool to constrain the populations of the early Universe.The European Space Agency (ESA) recently selected the NASA-nominated science program, LIBRAE (Looking at Infrared Background Radiation Anisotropies with Euclid), to carry out a measurement of the CIB fluctuations with the upcoming Euclid space telescope. Scheduled to launch in 2018/19, the timing is ideal to enhance our understanding of the CIB fluctuations and make testable predictions for Euclid that will facilitate the interpretation of data. The project will enhance Europe's competitiveness in this field and transfer valuable knowledge from NASA/GSFC creating lasting collaborations between the United States and Europe.The proposed project has three major research objectives that each addresses the nature of the CIB from a different perspective. First, the fellow will investigate the origins of the CIB and its relation to the epoch of the first stars and black holes with robust implications for Euclid. Second, the fellow will  construct mock survey maps to simulate the removal of foreground galaxies necessary to reveal the unresolved CIB signal. This will use state-of-the-art cosmological simulations at the host institution. Third, we will use an innovative method to isolate the CIB from early epochs using data from the Fer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Nanoscale Machines Exploiting the Casimir Force' (NANOCASE), addressing dissemination and exploitation.

assistant: **Impact**

The Casimir force is the attraction between optical boundaries arising from the quantum zero-point energy of the vacuum and since its prediction in 1948 has remained the simplest way of detecting experimentally the energy density of empty space. It only becomes measurable in the sub-micron range and, for flat boundaries, increases with the inverse fourth power of their separation. This project proposes to discover ways to use the Casimir effect to provide a contactless transmission of force in nanoscale machines. The consortium from three countries (UK, France and Sweden) will combine nanolithography, cryogenic STM and modelling by quantum field theory to study the Casimir force in flexibly shaped optical cavities. The measurements will be pushed to hi gher precision than before in conditions of ultra-high vacuum and low temperature and to smaller separations down to tens of nanometres. The aim is to understand the effect of the geometry and the optical properties of the cavity material on the force so that it can be optimised to produce the maximum 'lateral' Casimir force that will enable a modulated boundary to drag another through empty space without physical contact. The suitability of the lateral force as a transmission mechanism will be investig ated and the final goal is to demonstrate contactless transmission in a simple nano-machine. The project will also provide data that will impose limits on parameters in current theories of new forces involving exotic quanta.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Career Development Fellowships in the National Technology Centre Programme'.

assistant: **Innovation**

The Career-FIT PLUS COFUND Programme proposes 50 three-year Career Development Fellowships to be situated in Ireland’s National Technology Centres with mandatory secondment to industry. The programme will be managed from the Research & Innovation Division of Enterprise Ireland (EI), a national industrial development agency with a mission that targets developing people and their capability for driving enterprise growth. The Career-FIT PLUS programme will have a duration period of 72 months with two calls for proposals. As the successor to the previously funded MSCA COFUND Career-FIT programme, the Career-FIT PLUS offers a maturity of approach with key learnings from the engagement of EI, the Technology Centres and the Fellows in Career-FIT incorporated into the enhanced Career-FIT PLUS programme. These provide for an improved platform for researchers to develop high quality proposals with the Technology Centres and their partner enterprises. It also reinforces a more structured basis for training and mentoring initiatives and actions developed during the implementation of Career-FIT, such as cross-over training across the Technology Centres. There is an intention to position the programme as a more central element of EI’s innovation portfolio, with a particular focus on enhancing the interdisciplinary platforms of the Technology Centres. The proposal is supported by a significant demand from enterprises relevant to the research areas of the Technology Centres. The total budget of the Career-FIT PLUS programme is €13,792,500 of which €5,517,000 is requested for co-funding.


**Keywords:** Technology Centre, Industrial development, Enterprise, Innovation, Career plan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cluster Of Systems of Metadata for Official Statistics' (COSMOS).

assistant: **Innovation**

This Cluster brings together five IST projects: MISSION, FASTER, IPIS, IQML and METAWARE, which have a shared interest in statistical metadata and metadata repositories. Drawing on standards such as the OMG Common Warehouse Metamodel, the project will identify a common core model for the metadata employed in the systems of the five projects, and develop a set of common APIs for a subset of this model, to demonstrate interoperability between the software of the five projects. The users in the Cluster come from National Statistical Institutes (NSIs), Data Archives and Public Administrations. Thus the project is in a position to disseminate its findings to a wide constituency of users, as well as through technical networks and concentration activities.Objectives:The objectives of the Cluster are fourfold:to build better metadata repositories by exchanging ideas and experience in using metadata systems for the individual projects;to identify a common set of metadata objects, with agreed definitions, attributes and methods;to implement a demonstration subset of these objects to show interoperability of the developed systems;and to define a methodology for further developing this interoperability.The Cluster will link with other concentration activities in the area and international standards bodies such as the Object Management Group (OMG), UN/EDIFACT and ebXML.To achieve these objectives, we aim to:(1) maximise the interchange between the key developers of the metadata models in each project;(2) give an opportunity for all participating institutions to meet and exchange experiences;(3) demonstrate the interoperability of the project outputs, while respecting the exigencies of each project plan.Work description:There are five elements of the Cluster's workplan:(1) Key design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of adenosine in placental development and function' (ADENOSINE).

assistant: **Concept**

Altered fetal growth patterns, i.e. reduced growth in utero (intrauterine growth restriction, IUGR) are associated with perinatal morbidity as well as adverse consequences in adult life, e.g. cardiovascular disease. A prevailing hypothesis regarding the pathogenesis of reduced growth in utero is the “ischemic model” where abnormal placental bed vascular pathology with reduced nutrient and oxygen delivery to the intervillus space as a result of diminished placental perfusion contributes to suboptimal fetal growth in the second half of pregnancy. Amino acids are an important nutrient during fetal development and their concentration and placental transport are significantly lower in growth-restricted infants. Recent studies indicate that a variety of signals such as adenosine are produced in response to hypoxia in tissues and are higher in women with preeclampsia and growth-restricted infants. However, to date there is little information about the role of adenosine in pregnancy and the placenta. Therefore, the focus of this proposal is to investigate the effect and mechanism of the hypoxia-inducible signal adenosine on placental development and placental amino acid transport.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Junb degradation in mitosis' to be submitted under Fifth Framework.

assistant: **Abstract**

JunB belongs to the family of AP-l transcription factors, some of which have been shown to play a critical role in the development of a variety of neoplasia. JunB is a negative regulator of cell proliferation which has recently been shown to have a tumor supressor activity in vivo. It is a metabolically unstable protein whose degradation is dramatically accelerated upon phosphorylation, most probably by the cyclinB/cdc2 kinase, in mitosis. JunB is an antagonist of c-Jun, another member of the AP-l family involved in the positive control of important cell cycle Regulators such as cyclin Dl. Consequently, it is believed that its destruction in mitosis is necessary for optimum activity of c-Jun during the Gl phase and proper progression from Gl to S phase in response to mitogenic activation. The molecular basis of the variations in JunB abundance during the cell cycle are still ill-defined. It is Therefore essential to elucidate how JunB is degraded for understanding its physiological functions but also because the cells components participating to its destruction are potential oncogenes since unphysiological degradation is a potential loss of function mechanism. Using a variety of molecular and cellular approaches, I thus propose to decipher the intimate mechanisms whereby JunB is degraded during mitosis with a particular attention to the ubiquitin/proteasome system. I will also investigate the precise timing of JunB degradation in M phase with recently developed microscopic techniques. Together with the development of the degradation-resistant mutants, these experiments will provided an experimental basis for determining whether JunB degradation in mitosis is necessary for proper progression through the cell cycle.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Innovative packaging solutions for storage and conservation of 20th century cultural heritage of artefacts based on cellulose derivate' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A huge percentage of the recent European cultural heritage (CH) can be found in movies, photographies, posters and slides produced between 1895 and 1970 were made using cellulose derivates. More than 75 years of visual and audio memories are in serious danger to be lost due to the natural instability cellulose acetate (CA) and Cellulose nitrate (CN) materials.These physical media have helped to preserve the cultural material that is a real witness of socio-cultural European evolution in the recent era. It encompasses the possibility to understand the development of new arts such as cinema, photography or graphic arts and also the preservation of the socio-cultural memories of citizens located in major and local museums worldwide.Conservators consider two approaches when planning treatments to extend the useful lifetime of cultural materials: preventive or passive and active or interventive. But in case of cellulose derivates and other components of the movie or photos, once initiated, degradation cannot be prevented, reversed or stopped, but only inhibited or slowed. Inhibitive conservation of cellulose derivates can either involve the removal or reduction of factors causing degradation including light, oxygen, acids, fungus and relative humidity among others, as well as cost-sensitive processes such as freeze. NEMOSINE improves the traditional storage solutions, such as freeze storage (below 5ºC), by developing an innovative package with the main goal of energy saving and extent conservation time. NEMOSINE will develop: i) High O2 barrier and Active packaging using non-odour additives, ii) Active acid adsorbers based on functionalized Metal Organic Framework (MOFs) integrated in innovative structures, iii) Gas detection sensors to monitoring AA, O2 & NO, iv) Multi-scal