RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Developing Chiral Isothioureas as Asymmetric Organocatalysts; Synthesis, Catalysis and Mechanistic Investigations' (ISOCAT) targeting Seventh Framework.

assistant: **Abstract**

Nucleophilic or Lewis-base catalysis encompasses a multitude of different catalyst types and reactions. Despite intense interest within this field, there still exists a need to develop novel small molecule catalyst architectures that display high catalytic efficiency and enantioselectivity in a range of C-C bond forming reactions. This project is concerned with the design, synthesis and validation of a range of chiral catalysts based upon the isothiourea architecture as Lewis bases. Building upon established precedent, materials will be designed that possess exceptional catalytic properties that will enable new asymmetric processes to be delineated. A full mechanistic evaluation of these catalysts will be completed, and applications of the optimised catalysts to carbocycle, heterocycle and natural product synthesis established. This project is of relevance to the Work Programme as it has the potential to generate excellent science and exceptional training for the Fellow that will help to contribute towards Europe’s scientific output and competitiveness. Furthermore, the professional development of the fellow will also be established, ensuring that she is well placed for re-integration with her chosen career path after the end of this fellowship.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Chemical Design of Redox-Bipolar Covalent Organic Frameworks as High Energy Density Cathodes for Li-ion Batteries'.

assistant: **Concept**

The development of sustainable rechargeable batteries with high energy density is one of the main current challenges to efficiently store energy from renewable sources. Among them, lithium-ion batteries (LIBs) are the most promising due to their superior performance. While conventional inorganic LIBs present limited energy density and problems associated with the availability of critical raw materials, electroactive organic materials are an attractive alternative due to their tunable electrochemical properties and resource availability. In particular, Covalent Organic Frameworks (COFs) have emerged as promising electrode materials, but in order to extend their applicability, their energy density requires to be increased. In general, n-type based COFs can lead to high specific capacities while p-type based COFs exhibit higher working potentials (>3 V vs Li/Li+). Thus, new design strategies to increase simultaneously the capacity and voltage are required. This project (BipoCOFs) aims to develop high energy density cathodes based on the construction of two-dimensional (2D) redox-bipolar COFs by combining n-type and p-type moieties within the same COF. In addition, the bipolar COFs will be exfoliated to improve ion diffusion and conductivity of the electrodes will be optimized in order to maximize the electrochemical performance. This project will implement a complex training in synthesis and exfoliation of redox-bipolar COFs in the host group combined with fabrication of COF-based buckypaper electrodes during the secondment to address the ambitious scientific objectives. BipoCOFs will merge the fields of organic batteries and COFs, encompassing synthetic organic chemistry, polymer chemistry, and materials science. The achieved results will lay the foundations for further d
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Development of microalgae-based natural UV Sunscreens and Proteins as cosmeceuticals and nutraceuticals'.

assistant: **Innovation**

The biotechnology of microalgae has gained considerable importance in recent decades, as they represent a largely untapped reservoir of novel and valuable bioactive compounds. The biological and chemical diversity of the microalgae, has been the source of unique bioactive molecules with the potential for industrial development as pharmaceuticals, cosmetics, nutritional supplements. The proposed project will combine both basic and applied research in the fields of –omics technologies, biochemistry, applied and enzyme biotechnology in order to exploit microalgae resources for the development: 1) Natural UV sunscreens, based on algae mycosporine-like aminoacids, 2) Algae-based nutraceuticals as functional foods and food supplements, 3) Algae-derived proteases with applications in cosmetic (skin repair enzymes) and food industry. The implementation of the project will offer to the involved academic and SMSs the opportunity to translate scientific research into well defined knowledge-based ‘green’ products and analytical tools. Apart from scientific objectives, the project will enhance the European’s capacity in the field of Blue Growth and Marine Biotechnology by exchanging interdisciplinary knowledge, developing and disseminating joint research activities, thus strengthening the intersectoral links between academia and industry for sustainable growth.


**Keywords:** Microalgae, novel products, genomics, transcriptomics, proteomics, enzymomics, cosmecuticals, neutracuticals, species identification and authentication, authentication of products
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European project for improvement of supersonic transport low speed efficiency' (EPISTLE) under Fifth Framework.

assistant: **Objectives**

Compliance with Community noise regulations is a critical design requirement of a second generation Supersonic Commercial Transport (SCT). EPISTLE aims to achieve an aerodynamic design methodology that yields SCT configurations with largely attached flow at the low-speed design points and thus realise considerable reductions in drag. This will in turn reduce airport noise levels. The objectives will be obtained by exploring the major design sensitivities of high- lift devices with numerical simulations, by establishing design rules and assessing various optimisation approaches. The numerical design approach will be validated with high-quality wind tunnel experiments. The resulting design methodology for swept SCT wings and the experimental database will yield reduced design turn-around times and improved overall SCT performance. The results will reduce the high industrial risk in SCT development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Hybrid ElectriC smAll commuteR aiRcraft conceptUal deSign' (HECARRUS).

assistant: **Innovation**

This thematic topic focuses on the design of a 19 passenger commuter aircraft based on alternative propulsion concepts (hybrid/electric) targeting near-zero CO2 emissions. A full design loop is required, evaluating a range of design options, resulting in a mature conceptual design for the selected design. The design should be compliant with the new level 4 FAR23 / CS23 regulation. HECARRUS employs methods suitable for analyzing advanced technologies implemented for propulsion and power generation, and takes full advantage of the latest advances in aerospace, electrification and autonomous technologies in a hybrid-electric propulsion strategy to couple the most efficient turbines with generators providing electric power and recharging batteries in several competent technologies, to cover a broad spectrum of these applications. The ultimate idea of the project will be to design a hybrid-electric system with a power output in the range of 1 MW utilizing two engines (two thermal cores) as the propulsive units of a 19-passenger short haul aircraft. With a focus on the key propulsion sub-systems, aircraft structure and performance that interfaces with existing conceptual design frameworks, this project will aim at full design space exploration of the various hybrid-electric concepts at low TRL level. It is underlined that the technologies described and investigated in view of this proposal are complementary to engine core technologies currently under investigation in other EU projects. In other words, the potential fuel efficiency benefits from HECARRUS can be stackedup to efficiency benefits from other projects as all the technologies gradually mature for entry into service by 2030.


**Keywords:** Hybrid propulsion, aircraft, conceptual design, short range aircraft, gas tur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Correlations and Topology in Electronic Systems' to be submitted under Seventh Framework.

assistant: **Abstract**

Electrons moving in a solid experience strong Coulomb repulsive interactions. These interactions can lead to extraordinarily fascinating and complex behavior at low temperatures, such as superconductivity and the quantum Hall effect. This proposal deals with the properties of many-electron systems in which the electron-electron interactions play an important role, changing the low-energy physics qualitatively, and leading to novel quantum states of matter which cannot be described by models of weakly interacting particles. In the first part of this proposal, I intend to pursue a new theoretical method of studying the properties of quantum critical points in metals. Such transitions are ubiquitous in many correlated materials, such as the high-temperature superconductors, and may hold the key to understanding some of the properties of these materials. The new technique relies on formulating a model which can be simulated numerically in an efficient manner, avoiding the well-known “fermion sign problem” which often hinders the study of models involvingfermions. Extensions of this technique to other fermionic models will also be explored.In the second part of the proposal, I will study properties of interaction-driven electronic phases that have an underlying topological structure. Such systems have drawn much attention in condensed matter physics, especially over the last few years, following the discovery of the topological insulators. I will propose new ways of realizing time-reversal invariant topological superconducting phases in composite structures of superconductors and semiconductor materials. Finally, I will study how interfaces between superconductors and quantum Hall systems, either in the integer or fractional regime, can lead to new types of topological phase
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Next generation allergen immunotherapy based on specifically modified recombinant hypoallergens' (AllergyVAX) targeting Horizon 2020.

assistant: **Abstract**

Allergy is a rapidly increasing, global problem that already affects 1 billion people and causes significant social and economic burden. In Europe, allergic rhinitis and asthma cause more than 100 million missed work and school days per year. Allergy is usually managed by avoiding the allergen or by medication that temporarily alleviates the symptoms. The only disease-modifying treatment available to date is allergen immunotherapy (AIT) where long-term symptom relief is achieved by training the immune system to tolerate allergens. However, typical AIT takes 3-5 years, involves monthly injections or daily drops/tablets and has the risk of serious allergic reactions during treatment. Thus, the popularity of AIT is still relatively low compared to symptomatic drugs. We have developed a platform technology for creating modified hypoallergens to be used in AIT. It is based on making small, highly targeted modifications to allergen proteins that reduce their ability to trigger allergic reactions during treatment without compromising their efficacy in building tolerance to natural allergens. With these modified hypoallergens, we expect to shorten the injectable AIT treatment from dozens of injections over 3 years to just 3-6 injections over a few months. From the clinically important major birch pollen allergen Bet v 1 we have created rBet v 1 dm hypoallergen. In preclinical tests it has shown 100-fold reduction in histamine release compared to natural allergens and induced similar immunological responses in mice that are desired in human AIT. In the AllergyVAX project we will test rBet v 1 dm for maximum tolerated dose and immunogenicity in allergic patients in a phase I/IIa clinical trial. The project will facilitate seamless transition to phase IIb-III clinical development,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Neural circuitry and health consequences of cognitive bias' (COGBIAS), addressing dissemination and exploitation.

assistant: **Impact**

Stress has long been a major concern among researchers interested in health and welfare. Most of their work has considered stress from either a biological or an environmental perspective, focusing on the activation of the physiological systems involved in the stress process or the role of stressful life events in specific diseases. While interesting, if we are to fully understand the effects of stress on health, we must also take into account a psychological perspective that considers an individual’s perception of stress. Indeed, a deep understanding of the neural circuitry underlying psychological stress and its physiological consequences is crucial to meaningfully explain inter-individual variations in vulneraibility to stress. In this way, my ongoing research has revealed some preliminary results which indicate ‒ for the first time ‒ that cognitive bias towards pessimistic judgments (i.e. some individuals consistently evaluate ambiguous stimuli as negative) may predict an individual’s susceptibility to the detrimental effects of chronic stress. These groundbreaking results shed light on a completely unexplored and highly promising avenue of research, based on the potential impact of evaluation biases regarding stress on an individual’s vulnerability to stress-associated diseases. In this framework, COGBIAS firstly aims to characterise the specific neural circuits underlying cognitive bias by which stress is perceived, processed, and transduced into a neuroendocrine response, using zebrafish (Danio rerio) as a model. Secondly, COGBIAS aims to unravel the role of subjective stress on resilience to stress-associated diseases. Hence, the multidisciplinary and unique perspective of this project, combining behavioural, neural, genetic, and physiological sciences, has the p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Agricultural-robotics technology company enabling a modular swarm of autonomous drones for spraying' (Skyx).

assistant: **Concept**

Skyx is an Agriculture technology company developing the ""brain"" (in software) for a swarm of modular and autonomous spraying robots. Started with drones.The technology: proprietary algorithms for complex space coverage (including static and dynamic obstacles), real-time swarm operation, homogeneous farmland coverage or “hot-spots” coverage for an unlimited number of spots and shapes. The innovative agriculture-technology “compiles” the terrain + crops + pesticides + the available machinery into an optimized mission planning, mission control, and auto-piloting of the robots.The product: you push a button and a group of robots sprays your farmland. There is no need to install the product on each robot. Each robot in the modular swarm can have different performance and accuracy level and therefore the optimized solution fit for small, medium, or large scale farmlands.Skyx product is for agriculture spraying service providers, and not for growers.The company: was founded by Eylon Sorek and Dr. Itzik Turkel, developed a working demo and established on-going cooperation with a Tier-1 agriculture spraying applicator. The team works intensively with the entire ecosystem including specialty crops growers, tier-1 aerial operator, tier-1 pesticides vendor, and drone builders.Recently an agriculture venture capital firm invested 500K EUR to continue the product development. An additional challenge is to analyze the potential of our solution internationally and validate our value proposition to every member in our commercial environment. Therefore, Phase-1 grant will help us testing our technology in various agriculture service providers in the EU and in America and also will help us validate our business model and alternative business models.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Autonomous Paper-based Point-of-Care Biosensing System' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The objective of this proposal is the development of a fuel cell powered point-of-care analytical device based on paper microfluidics. The device would comprise a power source, biosensors, electronics module and display, to allow the autonomous quantitative measurement of a biological sample and visualize the results within a thin, flexible and disposable package. A first phase of the project (outgoing) will be dedicated to acquiring the skills and methodology to develop paper-based microfluidic devices such as fuel cells and biosensors. The second phase (return) will be dedicated to transfer these skills into the host organization and integrate the paper-based fuel cells and biosensors with the proper electronics and display on a flexible plastic substrate. The outcome of the project will be a functional working prototype transferable to the manufacturing technology used in organic electronics (OE).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exploiting Protein Complexes that Induce Cell-death' (EPIC).

assistant: **Concept**

The formation of specific protein complexes are key events in life-and-death decisions made by cells. Inappropriate decisions underpin a plethora of disease conditions from degenerative diseases to cancer while the role of the complexes in these processes make them important therapeutic targets. Our ability to develop small molecules to target death-inducing protein complexes has been hampered by an inability to measure complex formation in cells in real-time and by the absence of robust high-throughput assays for the discovery of new lead molecules that target these complexes. The proposed network (EPIC) will address both of these problems by developing new approaches to measure necrosome and apoptosome formation in real-time as well as new high-throughput and high-content screening assays using Fluorescence resonance transfer and split-luciferase technologies.EPIC will conform with the H2020 work programme by integrating research activity, novel reagents and expertise across Europe and world through the mobility, knowledge transfer and training of experienced and early stage researchers from within and without the EU. EPIC will realise the potential of researchers through the development of new skill-sets, the transfer new skills between academia and industry, and the development of career opportunities for EU ESRs and ERs. A key part of this activity is the mobility of non-EU researchers and the inward transfer of essential knowledge from outside the EU to benefit EU-based research. Establishment of EPIC through RISE will generate lead molecules with demonstrable utility and knowledge that will underpin applications to national funding agencies to sustain the communal effort beyond the life of the RISE award. It will also generate intellectual property that will enab