RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'From Subatomic to Cosmic Scales: Simulating, Modelling, Analysing Binary Neutron Star Mergers' (SMArt).

assistant: **Innovation**

What is the nature of matter at supranuclear densities? What is the expansion rate of our Universe? These open questions of nuclear physics and cosmology can be answered with multi-messenger observation of merging binary neutron stars. The window to study these fascinating events has only recently been opened with the upgrades of gravitational-wave observatories and by combining gravitational-wave information with that of powerful telescopes in the electromagnetic spectrum - from infrared, to optical, to gamma-rays. In the near future, we expect numerous multi-messenger observations of compact binary systems. We are currently at a crossroads in which the development of accurate and robust theoretical models is crucial to keeping up with the development of experimental instrumentation. Without noticeable upgrades of our models, future analyses will be biased through modelling uncertainties.The proposed research project will focus on the development of theoretical models to interpret the binary neutron star coalescence and will pave the way for a thorough understanding of the merger process. Novel methods and algorithms that we will implement in our numerical-relativity code will allow us to study previously inaccessible regions of the binary neutron star parameter space with unprecedented accuracy. This accuracy in the determination of the gravitational-wave and electromagnetic emission from binary neutron star mergers is essential for connecting our theoretical computations with observational data. We will push for a publicly available framework for the simultaneous analysis of gravitational-wave and electromagnetic signals from binary neutron star mergers incorporating also nuclear-physics calculations, nuclear-physics experiments, and other astrophysical observations
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Advanced technologies for zeroing in on high-grade gliomas'.

assistant: **Innovation**

Despite advances in diagnosis and therapy, glioblastoma (GBM) remains one of the most challenging cancers to treat, with overall survival under two years and a five-year survival rate of just 5%. This poor prognosis stems from three key factors: anatomical barriers, biological heterogeneity, immunosuppressive tumor microenvironment (TME).GlioZERO will establish a network of scientists with expertise in drug delivery, immunology, neurosurgery, robotics, and computational sciences to design microstructured polymeric films (microGRID) enabling deep, uniform, and sustained release of various therapeutic agents at the tumor margins; assess the efficacy of multimodal therapies in rigorous GBM models, leveraging microGRID to overcome anatomical barriers and systemic toxicity; improve surgical resection through intraoperative AI-assisted imaging; and employ advanced biological mapping to identify post-surgical TME alterations driving recurrence.To achieve these objectives, GlioZERO will bring together two EU Research Institutions, specialized in drug delivery, robotics, imaging (IIT) and brain cancer biology (Curie); two EU Enterprises, with expertise in neurosurgery (HUM) and computational modeling (BioIRC); four world-renowned US institutions advancing various therapies against GBM, including targeted therapies and immunotherapies (Stanford), oncolytic viruses (MD Anderson), anti-epileptic therapies (UCSF), and image-guided surgical therapies (BWH); and a Japanese partner (KU), focused on nano-therapies. Through interdisciplinary, intersectoral, and international secondments, GlioZERO will train a new generation of EU scientists, develop a novel class of drug delivery systems, and identify more effective therapies against GBM. Finally, partnerships with biotech accelerators i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The roles of juvenile NMDA receptors in synapse maturation and elimination and their association with cognition' (NMDAR-synprun).

assistant: **Innovation**

The aim of the project is to understand how the NMDA receptor subunit NR3A is involved in selective synapse elimination (“pruning”) during development and how the abnormal expression of NR3A found in mental disorders such as Schizophrenia, Alzheimer´s disease and Huntington correlates with the reduction of functional synapses and deficits in the cognitive function. Importantly, the Host lab has already proved that restoring the normal NR3A expression levels reverses both, the spine lost and the cognitive impairment in mouse models. My working hypothesis is that NR3A and its associated signalling complexes act locally as a brake on the maturation of specific synapses to direct targeted, activity-dependent destabilisation and pruning. I will test this hypothesis by: 1) studying mechanisms that underlie the inhibitory effects of NR3A on synapse stabilization or its facilitation of pruning, 2) evaluating how genetic manipulation of NR3A signalling pathways affects cognition. Candidate inhibition/pruning mechanisms that will be tested here include destabilizing effects of NR3A in NMDA receptor mobility within the plasma membrane, altered NMDAR synaptic localization, and recruitment via intracellular domains of NR3A of signalling complexes driving synapse destabilization and disassembly. Specifically, I will use a combination of established and recently developed imaging, molecular biology, electrophysiology and behavioural techniques in primary neuronal cultures, brain slices and the whole animal. The proposed work not only will reveal the molecular links between NR3A expressions, neuronal connectivity and cognitive function in the normal brain, but also will provide and validate suitable targets for the therapeutic intervention in mental disorders where synaptic lost underl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evolutionary ecology and levels of selection in insect societies' (1998-2002).

assistant: **Concept**

The ecological success and the unique features of social insects makes them prime objects in both evolutionary and ecological research. Social insects, however, also share a multitude of traits with plants, including competitive interactions between neighboring units. In particular, multinest societies of ants resemble in many respects vegetative propagating plants - both are tied to a site of growth/nest, both produce ramets or daughter nests and engage in long-range sexual dispersal mediated by sexual entities. Several recent models have considered the effects of competition of growth patterns and territory size in plants. Given the striking parallels that exist between ants and plants, such models can be expanded so that predictions can be derived for ant colonies. However, no studies have explored these possibilities. My aim is to expand current theory on competitive interaction in plants to generate predictions that can be tested in multinest societies of ants. Furthermore, I will test these predictions empirically in two species of ants, Formica truncorum and F polyctena, which differ in their degree of population sub structuring and therefore the intensity in competitive interactions. The results will provide new insights into levels of selection theory , kin selection theory as well as the spatial ecology and population dynamics of multiqueen, multinest societies of ants, and will be a significant contribution in understanding the ecological success of such societies. The host institute has a strong international reputation and excellent expertise in both experimental and theoretical work. Weekly high-profile seminars in English with frequent international guests guarantee contacts with a broad range of topics in ecology and evolution. The Spatial Ecology" progr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Trash-2-Cash: Designed high-value products from zero-value waste textiles and fibres via design driven technologies' (Trash-2-Cash) targeting Horizon 2020.

assistant: **Abstract**

Within Trash-2-Cash, growing problems with paper fibre waste from the paper industry and textile fibre waste, originating from a continuously increasing textile consumption, will be solved through design-driven innovation. This will be performed by using the wastes to regenerate fibres that will be included into fashion, interior and other products. The cotton production suffers from non-sustainable environmental and socio-economical issues and the polyester fibre manufacture produces waste that to date has no viable deposition. Designers will lead the recycling initiative, defining the material properties, and will feed the material scientists to evaluate newly developed eco-efficient cotton fibre regeneration and polyester recycling  techniques. The future exploitation will be ascertained through a two-sided exchange between the designers and the end-product manufacturers, also taking into account the consumer-related product needs, and prototypes will be produced in a realistic test production environment.The objectives are to:• Integrate design, business and technology to a coherent discipline to establish new creative industries• Develop new material and product opportunities via creative design from waste or process by-product• Reduce the utilization of virgin materials; improve material efficiency; decrease landfill volumes and energy consumption• Use design for recycling with the vision of closing the material loop• Create new business opportunities by adding the return loop of the discarded goods to be reused into attractive products• Promote development of the creative sector by providing technological solutions for exploitation of waste streamsEurope's creative industry will be strengthened through Trash-2-Cash taking the lead worldwide in the design for recy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'SmartGrids ERA-NET' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

SmartGrids ERA-NET develops transnational research activities to speed up the development of a Smart European Electrical Infrastructure. A necessity for a successful realisation of the European Action Plan “Energy Policy for Europe”.  This will change the European electricity supply with strong consumer response, large scale supplies of renewable electricity and high levels of distributed generation. SmartGrids ERA-NET provides co-ordination of the related research activities within the national and regional public (co)funded RTD. To make a kick start, the consortium already defined three logical issues for joint calls Electrical Transport Systems; Electrical Distribution Systems and Regulatory Issues. SmartGrids ERA-NET creates a network of programme managers, closely connected to policy makers and industry that undertakes joint activities. The objective of SmartGrids ERA-NET is the mutual opening up of the research programmes, research infrastructures and joint activities (calls). The ambition is to establish cooperation beyond the ERA-NET and between RTD managers EU-wide. The work plan foresees 4-step approach:  • Step 1: Exchange of information • Step 2: Strategic activities and best practices • Step 3: Implementation of joint activities • Step 4: Transnational research activities  The Consortium represents National and Regional programmes of 12 European countries, which gives the SmartGrids ERA-NET the critical mass required for successful operations. All members have assigned senior staff to this ERA-NET, who are experienced with home front programmes and international cooperation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Breakthrough cold generation technology for efficient & environmentally-friendly cooling.' (2021-2027), addressing dissemination and exploitation.

assistant: **Impact**

We have developed a new cooling technology based on the principle of adiabatic expansion. Compared to the traditional vapour compression technology: It uses air instead of toxic HFCs to transfer energy, eliminating this source of pollution and therefore reducing CO2e by 50%. In DAC, the energy extracted from the cooled air is not emitted as heat into the atmosphere but turned into electricity unlike in traditional vapor compression AC/refrigeration units.This electricity is used to contribute up to 30% of energy required for powering up our units, hence it is 30% more energy efficient compared with traditional compression systems (lower OPEX). This means that they are much cheaper to run.Due to much simpler design and smaller size, manufacturing costs of our devices are up to 30% lower (lower CAPEX).DAC tech can cool any air (regardless of its humidity or initial temperature) down to -90°C within seconds from the start of operation and under very low pressure.


**Keywords:** Clean air conditioning,Cooling,Refrigeration,Hydrofluorocarbons,Gas-dynamic,Decontamination and de-pollution,Environmental and Green Technologies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Biodiversity of Coastal Marine Ecosystems' under Fifth Framework.

assistant: **Concept**

The objective of our proposal is to inventory, summarise and generalise the scientific knowledge on the structure and function of marine biodiversity in coastal marine areas of Europe. Now that the Rio Convention has been ratified by nearly all European countries, and by the European Union, it becomes clear that the knowledge required to cover the obligations of the convention is simply not available, even in Europe where the seas have been explored since hundreds of years and taxonomic and general ecological knowledge is well advanced when compared to other areas of the world. Despite the broad definition of biodiversity adopted in Rio, covering variation in genes, species and habitats, biodiversity has for some time been associated with species and taxonomy only. Several efforts are presently underway to Inventory Europe's flora and fauna. These have shown that a lot remains to be discovered, even in Europe, for example microbial diversity, diversity in cryptic habitats like submarine caves, symbionts and parasites, viruses and fungi etc. Perhaps more important is that the ecological role of biodiversity has hardly been addressed at all.The relationships between the three components of biodiversity, genetic, species and habitat diversity, have hardly been explored and the role of biodiversity in marine ecosystem functioning is still largely unknown. Marine research has borrowed its concepts and paradigms from terrestrial biodiversity studies and there is no substantial body of knowledge on the subject. Adequate assessment of the risks to marine systems due to species or habitat loss or to accidental species introductions is therefore at present impossible. The proposed Marine Biodiversity Conference aims at increasing relevant knowledge by a stepwise approach in which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Holographic Assembler for 3D Cell Cultures' (HOLOCELL) under Horizon Europe.

assistant: **Objectives**

Cell cultures are essential for biomedical research and drug screening. The environment and the arrangement directly affect cell function. It has become clear that biological cells behave differently when cultured on a surface as opposed to a 3D environment. This discrepancy between 2D in vitro studies and the 3D environment found in vivo is critical for cancer research, most notably patient-specific therapy and high-throughput drug screening and discovery. Almost 90% of all drug candidates fail during the trial phases and one of the main reasons identified is the low physiological relevance of 2D cell cultures.  Technologies are needed that enable the fast and efficient culturing of 3D cell assemblies with high repeatability and control over size and morphology. Here, we use our recently developed technology and fabrication know-how together with the expertise from our ERC-funded research to realize the first 3D bioassembler where the shape of the cell aggregates can be precisely defined by the user. Within this ERC-POC grant we plan to develop a fully operational, stand-alone benchtop bioassembler that instantly aggregates biological cells, spheroids, particles or hydrogel capsules into fully defined 3D structures using acoustic holography. Our device will be an easy-to-use and affordable instrument that is fully compatible with established biological procedures and laboratory equipment and which allows scientists to culture the specific cell structures they need. The grant will allow us to protect our know-how, identify further markets, and develop a commercialization strategy for our technology.  Overall, this project will generate the first 3D cell assembler that permits the generation of user-defined cell spheroids and custom shapes at a press of button and thus p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Lab-on-a-chip based analyzers for point-of-care monitoring of cancer therapy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The objective is to develop advanced disposable chips, for point-of-care multi-parametric analysis of protein cancer markers. It is important to note that monitoring of multiple markers is essential to improve the reliability and the specificity of the analysis.The complete analytical instruments will comprise of disposable chips and a control unit, with dimensions of a credit card and book respectively. The essential functional blocks needed for sample preparation and analysis will be developed and integrated into a single chip.This includes such functions as the extraction of the serum from a drop of blood, protein pre-purification and pre-concentration and immuno-electrochromatographic separation, to assess quantitatively the cancer markers of interest. The final detection of the concentration of cancer markers will be based on integrated optical components (optical guides, Y-junctions) implemented in the chip and coupled with micro-fluidic channels.This integrated optical system will be used for guiding the excitation light on the chip, excitation of a fluorescence signal at the end of several separation micro-channels and for collection of the fluorescence response. The developed technology (chips + control unit) will be inexpensive, autonomous, and straightforward in its operation and interpretation.It will provide a new platform capable of performing frequent and cost-effective monitoring of tumour biomarkers at the point-of-care or in small analytical laboratories. This will improve the comfort of life of cancer patients and allow a more efficient therapy management.