RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Best practices to bring research and innovation in European SME through the peer review" method"' (2002-2006).

assistant: **Concept**

Research and Technological Development is essential for the functioning and sustainability of the European economy and therefore in the center of EU's development agenda. Small and Medium Enterprises are, on the one hand, the economic 'backbone' of the EU. On the other hand it is more difficult for them to do research on their own or to get the necessary scientific input for innovation.In order to strengthen the scientific and technological bases of the European industry and to encourage its international competitiveness it is indispensable to exchange on successful R&D policy approaches not only among Member States but also with states from the EU's new neighborhood and other countries that succeeded in having a competitive edge.Therefore the main objectives of EUROPEER SME are:- to foster mutual learning, elaborate best practices and improve impact of national and regional RTD support programmes to SMEs- to optimize the exchange of best practices by identifying conditions for transferability and developing transfer schemes- to diminish overlap and strengthen the co-ordination of RTD policies directed to SMEsTo foster mutual learning, to identify and evaluate best practices in the field of research policy making the peer-review method will be utilized. In order to improve the exchange of in-formation and to analyze the transferability of best practices a systematic approach will be introduced. A continuous, dynamic and mutual learning process will on the one side provide insights into how existing RTD and innovation policies may be improved and made more effective.On the other side it will lead to a sustainable network which is self-supporting after the end of the project and remain open for new members. The network will thereby help to strengthen the co-ordination of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Fundamentals of modern methods in biocrystallography' in the context of a Fifth Framework call.

assistant: **Objectives**

This course will be focused on Macromolecular Crystallography, by developing the fundamental theoretical concepts of Crystallography and illustrate these by tutorial and practical sessions.This is particularly important due to the rapid development of this field and also due to the fact that many young researchers do not receive a formal education in Crystallography. Additionally, with the introduction of high-throughput methods, the need to understand and grasp the theory behind modern methods will certainly be critical to overcome the difficult problems that will arise and will not be solved by the automated procedures.Topics of the course will run from fundamentals such as symmetry, point groups and crystal systems, basic diffraction physics, reciprocal space and the Ewards sphere, radiation damage, data processing, symmetry in the diffraction pattern, structure factors, Patterson function to developments on methodologies regarding the molecular replacement, SAD, MAD, MIR and maximum likelihood phasing, direct methods, density modification, refinement, model building, twinning and structure validation.Spreading knowledge and good practices at state-of-the-art level is particularly important in the rapidly expanding Macromolecular Crystallography community. A firm knowledge of the fundamentals of crystallography is also a prerequisite to fully and efficiently exploits large-scale facilities such as synchrotrons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for '4G MC-CDMA multiple antenna system on chip for radio enhancements' in the context of a Sixth Framework call.

assistant: **Objectives**

The European vision for 4th generation terrestrial system is a fully IP-based integrated system offering any kind of services, at any time and able to support multiple classes of terminals. In order to accommodate future services requiring high capacity, a broadband component is envisioned with a maximum information bit rate of more than 2-20 Mbps in a vehicular environment and possibly 50-100 Mbps in indoor to pedestrian environments, using a 50-100 MHz bandwidth. One of the most promising technologies for this broadband component is MC-CDMA (OFDM-CDMA), which combines the merits of OFDM with those of spread-spectrum techniques.4MORE will research and develop an innovative architecture compatible with advanced algorithms, and will validate a cost-effective, low-power System on Chip (SoC) solution on a demonstration system, for multi-antenna MC-CDMA mobile terminals, based on joint optimisation of L1 and L2 functions. The strong emphasis put on the achievement of a SoC design is motivated by the competition present in Japan. 4MORE will take advantage of the potentialities offered by MIMO techniques in order to achieve the required broadband capabilities. Furthermore, the design of the L2 components (IP traffic mapping, dynamic resource allocation, etc.) will be deeply interrelated with L1 (space-time coding, array processing, interference cancellation, synchronisation, etc.), in order for the L3 IP-based services to fully exploit the high throughput offered by the physical layer.4MORE will target high bit rates and high mobility in geographically restricted areas, i.e. a complement-type scenario according to the ITU-R vision for systems beyond IMT2000. As a result, the project will develop and integrate a set of IP (intellectual property) blocks at the terminal level. M
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Administrative Document Automate Optimization' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

ITESOFT and CVC plan to develop together a transfer of knowledge program. The vector of this program will be the design of an automatic document processing system.   Public organizations, social security services and large companies handle every day a large volume of various documents : identity cards, forms, mails, etc. They look for help in process optimization, cost reduction and customer satisfaction. The automation is an answer.  The French SME ITESOFT has developed products to automate the classification and the data extraction from administrative documents. More recently ITESOFT has prototyped a new generation of software which still need improvement on key-technologies : Graphs matching algorithm, Logo classification, Handwritten recognition, Document graphical classification, Document segmentation for overlapping documents, Color image segmentation.  The Document Analysis and Pattern Recognition Group of the public lab Computer Vision Center (CVC) in Barcelona has large R&D experience in the field of Document Image Analysis and Recognition. The group is doing active research in symbol recognition, indexing and browsing by graphical content, sketchy interfaces, diagrammatic reasoning and visual languages for graphic documents, graphics recognition architectures, reading systems for forms and structured documents, camera-based OCR.  We identify several knowledge and skills that can be exchanged between ITESOFT and CVC and combined to breakthrough the current state of the art.  This program will mainly involve staff exchanges. We also plan recruitments and workshops with researchers from outside the consortium. The staff exchanges will lead small collaborative teams to work together on the key-technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Visualizing the structural synaptic memory trace: presynaptic partners of newly formed spines'.

assistant: **Innovation**

The formation and elimination of spine synapses can be visualized both in vitro as well as in vivo using advanced imaging techniques. It is known that the number of dendritic spines changes both during development as well as during the acquisition of new memories. However, up to now these observations are entirely correlative. It is unclear if the presynaptic neuron forming a functional contact on a newly formed spine indeed was the one that showed correlated activity with the postsynaptic cell as would be required for a learning mechanism following classical Hebbian plasticity. In fact, since it has never been shown what information is transmitted via a newly formed spine synapse in vivo, it has yet to be demonstrated that new long-term stable spines indeed could carry a memory trace related to a specific previous experience.Here, I propose to functionally identify the presynaptic partners of newly formed spine synapses. I will assess if the information carried by a new spine can be predicted from readily observable global changes in neuronal activation strength in a well-defined sensory deprivation paradigm in vivo. Furthermore, I will study whether indeed neurons that ‘fire together’ also ‘wire together’ by forming new stable spine synapses in vitro.I will develop chronic single spine Ca2+ imaging techniques and novel optophysiological tools like a dual-color genetically encoded Ca2+ indicator (GCaMP3-based) and an activity-dependent structural tag (TetTag-based) of active axons. I aim to functionally define the active presynaptic population in during visual and electrical stimulation in vivo and in vitro. Furthermore, I will assess if deletion of proteins involved in the functional maintenance of synaptic strengthening (LTP-maintenance) prevents the formation and/or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Nano Photonics-Based Micro Robotics'.

assistant: **Concept**

The general goal is to bring together different fields of research in order to create a new research area of photonic micro robotics. That is to create, study, and implement truly microscopic structures with nano scale accuracy that can perform robotic tasks and that are entirely powered and controlled by light. This idea brings immense challenges both from the point of view of the physics involved as well as the chemistry needed to create the appropriate materials, but if successful can also have a huge impact.To achieve this, we will combine our expertise on complex photonic materials and direct laser writing, to create micro structured patterns in liquid crystal elastomers, which are rubber-like polymers with liquid crystalline properties that can be triggered with light. In our view, this opens up a new strategy to create robots of various kinds, on a truly micrometer length scale. That is, micro robots that can swim, walk, or crawl, and when at destination perform specific tasks, controlled and driven by light.This proposal, in the first instance, deals with fundamental, curiosity-driven research and wishes to address the wealth of physics and chemistry that arises when combining nano photonics with micro robotics. Having said that, the range of potential applications is very broad. Our photonic micro robots would be able to penetrate otherwise difficult to access environments and perform tasks such as sensing or sampling. They could be made in large quantities which means they could also be put into action collectively in swarms (using mechanical and/or optical interaction between the individual robots).The project is truly interdisciplinary, which makes it very challenging but also exciting. The photonic micro robotic structures will be created by bringing togeth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Spatio-temporal dynamics of immune circuitry in glioblastoma: from single cells to comprehensive models of tumor niches' under Horizon Europe.

assistant: **Concept**

Glioblastoma (GBM) is the most lethal brain malignancy in adults and is associated with a poor prognosis. Therapy options in GBM patients are largely limited by the highly immunosuppressive tumor microenvironment (TME). Identifying and disrupting these immunosuppressive communication circuits between immune cells and the tumor is key to reinvigorate the immune system’s ability to fight the tumor. Here, we combine my previous experience in the analysis of single cell data at the neuro-immune interface with Prof. Zeiser’s patient-centered expertise in developing novel therapy options to combat tumor immune escape. In this highly complementary setting, we propose a data-driven approach to trace and perturb inhibitory communication circuits elicited by the TME across space and time with the aim to discover novel immunotherapeutic targets in GBM. Using a novel temporal single cell technology, we will 1) assemble a multi-layered spatio-temporal single cell roadmap to characterize and model how individual immune cells are affected by the TME in a murine model of GBM. 2) We will develop a computational framework for spatial transcriptomics to dissect single cells into niches defined by similar interaction programs with neighboring cells. 3) Using this tool, we will quantify the niche organization in human patients and identify ligand-receptor interaction pairs crucial for niche maintenance. 4) Candidate genes will be genetically ablated in either the tumor or the immune compartment and evaluated with regards to their in vivo efficacy in suppressing tumor growth. Our cutting-edge analytical pipeline from the identification of driver molecules for immune escape to the assessment of in vivo efficacy in a preclinical model of GBM will reveal novel targets for treatment. Our study t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Application of a novel spray nozzle to industrial flue gas scrubbing'.

assistant: **Innovation**

The project will investigate the feasibility of adapting a novel water spray nozzle for inclusion in an industrial wet scrubber designed to reduce particulate and flue gas emissions. Initial consideration indicates that the properties of the aerosol spray hold significant advantages over conventional methods which will lead not only to a technically better system, but also to significantly reduced running costs. However the spray characteristics must be quantified fully to overcome present manufacturing difficulties and to maximise the benefits of the design. Specifically, a significant cost reduction along with increased efficiency may be achieved through better water droplet characteristics. This is particularly true if employed as part of a chemical spray system where large savings can be made if the total volume of flow (due to smaller droplet size) can be reduced. The work programme will seek to quantify the spray characteristics from the nozzle and to propose refinements to meet the needs of the new application. Further tests on a laboratory scale chimney will demonstrate the efficiency of the spray in comparison with other systems. It is expected that such a device will meet the demands of the philosophy embodied within BATNEEC: Best Available Technology Not Entailing Excessive Cost, first used in the EC Framework Directive on Combating Air Pollution from Industrial Plant (84/3601EEC). Thus significant markets are envisaged if efficiency gains and cost reductions can be achieved, with consequent benefits to pollution control within the Community.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'A systems approach to defining membrane protein networks and applications'.

assistant: **Objectives**

Membrane proteins are macromolecules of huge academic and biotechnological importance. They account for ~30% of genes in prokaryotic and eukaryotic genomes, and perform a spectrum of essential cellular functions. Despite their importance, these proteins are poorly understood with respect to membrane insertion, folding and complex formation. Even less is known of the interactions between membrane protein complexes, or with other compartments in the cell. This application aims to establish a multidisciplinary initial training network for early-stage researchers in which leading European groups in membrane protein chemistry, bacterial systems biology and biotechnological applications join forces to achieve top-level training in an ambitious academic and industrial setting. Training and research will be fully integrated in a systems approach for the hierarchical analysis of membrane proteins. Key objectives are to understand how individual membrane proteins insert and adopt a unique structure (Research Topic 1), how they assemble into multimeric complexes (Research Topic 2), and how they communicate ('network') with each other and the rest of the cell (Research Topic 3). Novel quantitative approaches combined with mathematical modelling will be used to accurately predict membrane protein behaviour at a systems level (Research Topic 4). Throughout the program, special emphasis will be focused on biotechnologically relevant protein secretion systems. Major scientific deliverables will be knowledge models of complex assembly and inter-complex interaction hubs. The proposed training program will be individually-tailored to provide a coherent grounding in multidisciplinary approaches, both theoretical and experimental. It will deliver network-wide systems biology training, and a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Innovative technology for capsule filling machines to boost the pharmaceutical manufacturing process' (TechnocaP) targeting Horizon 2020.

assistant: **Abstract**

TECHNOCAP project is based on the industrialisation and commercialisation of a cutting-edge technology for capsule filling machines capable to significantly improve productivity, flexibility and quality of production for pharmaceutical companies. The pioneer of this disruptive project is MG2 S.r.l., industrial company specialized in the design, manufacturing and marketing of automatic machines for pharmaceuticals.Capsules are the most versatile of all dosage forms, in which one or more medicinal and inert ingredients are enclosed in a small shell or container usually made of gelatine. Nowadays, the regulatory authorities (EMA, FDA) are increasing exponentially their demand in terms of quality and dosage accuracy of the finished product. In fact, current technological solutions are reaching their limits, directly affecting the small, medium and large size pharmaceutical companies and their derived supply chain (i.e. pharmacies and consumer patients).Working in close collaboration with our customers in the pharmaceutical sector to response to inefficient methods present in the market, MG2 conceives TECHNOCAP, an innovative technology for capsule filling machines to boost the pharmaceutical manufacturing process. This technolog is able, under production rate, to control 100% of the weight/presence of all filled capsules to guarantee optimum end product quality, while enabling in real-time continuous data collection, analysis and interpretation to be used in production and quality control activities. As this project addresses MG2 commercial and technical strategies, we strongly believe that it will contribute to boost the growth of our company achieving, after 5 years of exploitation, 11% of market penetration, 28M€ of accumulated gross profit translated into a ROI ≥ 8.18 (
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of a physically-based research tool to conduct virtual experiments to solve problems in steel metallurgy (VESPISM)'.

assistant: **Concept**

The steel industry needs continually to develop new products and improve existing grades, improve process efficiency, reduce energy consumption and increase its levels of recycling. All such developments are very expensive and time-consuming by the traditional sequence of laboratory, pilot and works trials, and current models are not physical enough to extend much beyond established results. Here, a highly physical research tool is to be developed to address this shortfall and to be applied to 4 initial target problems. The chosen Phase Field method is able to calculate kinetic and morphological evolution in solidification, grain growth and solid state phase transformation, and should be suitable for recrystallisation and texture. This metallurgical modeling capability will be markedly extended and validated and then applied to a range of specified industrial problems through 'virtual experiments'.