RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European infrastructure for Rydberg Quantum Computing', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

EuRyQa aims at establishing Rydberg quantum processors as a leading platform for scalable quantum computing. Rydberg atoms have already provided proof-of-principle demonstrations of all the requirements for general purpose digital quantum computing and are today the only platform that has demonstrated more than 200 qubits with strong interactions and with a clear path to further scalability and eventually fault tolerant operation. To develop the next generation of fully programmable and scalable quantum computing systems based on Rydberg atoms and open them up for the European community now requires a coordinated interdisciplinary and intersectoral effort. For this, the EuRyQa consortium combines partners from academia and the private sector that are at the forefront of cold-atom technology with key industrial partners with complementary expertise on quantum hardware, classical electronics, firmware, and software. The project will bring together four Rydberg platforms with 100-1000 qubits, including three nationally funded platforms and one leading European start up, to provide a unique European solution to Rydberg-based quantum computers together with Europe-wide benchmarking and standardization of the technology. We will provide a common quantum computing stack for Rydberg atoms, a federated cloud service, solutions to concrete computational problems leading to a quantum advantage, and key technology and a blueprint for fault-tolerant quantum computing with Rydberg qubits.


**Keywords:** Neutral atoms, Rydberg qubits, multi-qubit gates, scalable quantum computing, quantum hardware, benchmarking
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Comparative transcriptomics of phylogenetically selected pathogenic treponemes cultivated in vitro under different conditions: First insight to the expression changes linked with genomic variants'.

assistant: **Objectives**

Syphilis, caused by the bacterium Treponema pallidum subsp. pallidum (TPA) is considered a re-emerging disease with over 5.6 million cases worldwide. Despite causing severe life-threatening infections, very little is known about the basic biology and pathogenesis of TPA, largely as the result of the inability to routinely propagate it in vitro. The recently described in vitro culture model (containing rabbit epithelial cells) has opened new avenues for the study of the basic biology of this pathogen. The ultimate goal of my research proposal is to take advantage of the in vitro model and link its use to high throughput genomic approaches to provide unique insights into the gene expression profiles of this pathogen. This has been transformative for other bacteria, enhancing our knowledge of genetic regulation: essential genes vs differentially expressed genes and intra- and inter-strain differences in response to different growth conditions. This has not been possible until now for TPA. Here, I will perform dual RNA-seq of multiple strains grown in vitro under different conditions. This research proposal has three aims. First, to describe global gene expression patterns of phylogenetically selected TPA strains. Second, to describe genome-wide interaction-linked transcriptional alterations of the infected host cells. And lastly, to correlate the whole transcriptome data with genomic and allelic diversity we see in circulating clinical TPA populations. This project will generate novel fundamental data which can lead to identification of functional pathways and prediction of the function for hypothetical genes, give light to the patterns of selection we see in genomic data and a better understanding of the key growth dependencies that could inform future axenic cultivation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A low cost and fully passive Terahertz inspection system based on nano-technology for security application' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective of TERAEYE is to develop an innovative range of inspecting passive systems, based on Terahertz (THz) wave detection, to detect harmful materials for homeland security. Main applications will be related to airports security systems, surveillance of crowded areas such as railway and metro stations; detection of chemical and biological harmful substances and hazards in post and goods. TERAEYE aims at a technological breakthrough in the THz sector through the development of a new fabrication process for cheap nano-fabricated 2-D matrix array of detectors that will strongly reduce the production cost of the THz sensors. These technological developments would constitute the basis for the longterm breakthrough introduction of totally new detection and scanning systems to be applied for security applications, thus opening up new market perspectives for a new set of products and services based on the passive THz detection, and thereby supporting a radical transformation in the security sector. TERAEYE has been conceived as an IP, being a large-scale industry-driven research initiative aimed at creating new applicable knowledge and integrating breakthrough technological solutions, having a strong inter-disciplinary character, in a full range of products and services. The project addresses vertical integration of the full value-chain of innovation stakeholders from the basic nanoscience-based development of the sensor through the industrial technology development, to the final product design and development. TERAEYE addresses horizontal integration as it fosters scientific multidisciplinarity (nanoscience, electronics, cryogenics, spectral imaging) and promises to trigger innovation in a variety of secondary industrial sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Nitrogen Cycling in Estuaries', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives: The project will study the fate of anthropogenic nitrogen discharged into estuaries and coastal waters. The removal of nitrogen in these waters will be quantified in order to evaluate to what extent nitrogen is being transported from land to the open seas. Contents: The processes leading to removal of nitrogen is burial of organic nitrogen in the sediment and bacterial denitrification which is preceded by a number of microbial processes in the sediment. To assess the importance of nitrogen removal on a European scale it is important to understand its regulation. A number of key parameters for the regulation of nitrogen removal have been identified: the presence of benthic primary producers, tidal range and climate. The benthic primary producers have been divided into three functional groups: benthic microalgae, marine angiosperms and floating macroalgae. One major part of the project deals with investigation of the mechanisms by which the benthic primary producers affect nitrogen turnover and the processes ultimately leading to nitrogen removal in coastal areas. The effects of tidal range and climate will be analysed by comparing four different study areas. We have selected two study areas in southern and two in northern Europe each representing micro and macro tidal conditions. The macro tidal areas are the Great Ouse Estuary in England and the Tagus Estuary in Portugal and the micro tidal areas are the Kattegat area between Sweden and Denmark and the Valli di Comacchio in Italy. In each of the micro tidal areas study sites have been selected in order to represent ecosystems dominated by each of the three functional groups of benthic primary producers. In the macro tidal areas benthic microalgae are the dominant benthic primary producers and they hence domi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Global Alliance for Chronic Diseases Secretariat', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The Global Alliance for Chronic Diseases (GACD) brings together leading health research funding agencies of key countries to coordinate research activities addressing on a global scale the prevention and treatment of chronic, non-communicable diseases such as cardiovascular diseases, diabetes, respiratory diseases, cancer and mental health. The GACD Secretariat supports its member agencies by helping to align research priorities, coordinating joint funding opportunities and maintaining a Research Network which aims to increase the impact of funded research projects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Tools for evaluating EU agricultual policy at different decision levels' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

An evaluation of the effects of the CAP at different levels is particularly important in relation to the CAP reform since 1992. At the end of the temporary period, while the Reform is also taking under considera- i tion the sectors previously excluded, the need for changes in the EU agricultural po, licy is increasing. The impact of the Reform will also be profondly influenced by the new EU scenario, the Unique Market, the GATT agreements, the extensions towards Northern States and the full application of Maastricht Treaty. The main aims of the project are: 1) The elaboration of different tools for evaluating EU agricultural policy at different levels: farms, Regions and Countries. We will set up supply models, on the one hand for a better adaption to the Reform, and on the other for a better representation at regional level. The evaluation of the agricultural policy at farm level will be carried out by representative groups and farm accounting system. 2) Dynamic analysis of rural development at regional level, in respect to EU reforms, The evaluation of regional models of endogenous development will be done by examining sectorial agricultural variables, but also the main features of the economic, social and environmental context. 3) The formulation of suggestions for a new effective, stable and sustainable agricul tural policy. The analysis will consider the behaviour of Member States and the coalitions with which agricultural policy might compromise. The results will be of three kinds: a) the creation of supply models which can be applied in all EU countries, with resul ts at farm, region and national levels, in order to evaluate the effects of agricultural policies on agricultural incomes, farms typologies, productive sectors, and also on land allocation. b) the crea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Studies on antigen presentation and immune recognition in hsp transfected tumor cells' (1994-1998).

assistant: **Innovation**

Research objectives and content The proposed project involves studies to increase the immunogenicity of tumor cells by transfection with a foreign heat shock protein gene. Heat shock proteins (HSPs) are abundant proteins of different molecular weight classes which are present in the cytosol as well as in all cellular organelles. During various physiological processes such as protein synthesis, degradation and transport through membranes, they bind to interactive sites of polypeptides thereby preventing their improper interaction with other molecules and enabling controlled further processing of the polypeptide in question. Previous studies with the macrophage murine tumor cell line J774 have shown that ex vivo insertion of a gene coding the Mycobacterium leprae HSP65 kDa into the tumor cells results in their inability to form tumors in mice and generation of effective antitumor immunity, indicating that the presence of the mycobacterial HSP65 kDa enhanced immunological recognition of unique structures expressed by the tumor cell. The mechanisms by which highly conserved proteins like HSPs are involved in eliciting immune responses are not clear. However, it is suggested that HSPs may act as carrier molecules to present immunogenic peptides. To investigate this mechanism we have initially generated primary cytotoxic T lymphocytes (CTL) utilizing a murine allogeneic system in vitro, and tested these cells for cytotoxic activity against mycobacterial HSP65 kDa transfectants of the murine mastocytoma cell line P815. The work to date has involved transfection of P815 cells with the mycobacterial hsp65 gene in order to establish the target cell line, generation of cytotoxic T lymphocytes capable of recognizing P815 cells and optimising the cytotoxicity assay in which P815 cel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'GABAergic INterneurons signaling ImbalancE; A promising target underlying PFC-dependent cognitive flexibility defects.' (GinieEffect).

assistant: **Concept**

Covid-19 pandemic has highlighted the importance of making decisions and adjusting our behavioural strategy to tackle unexpected changes in our environment. The cognitive flexibility required to modify behaviour when the rules change is ascribed primarily to the prefrontal cortex (PFC), but the exact mechanisms underlying this phenomenon remain unknown. Inhibitory GABAergic interneurons (INs) seem to play a key role in this process by modulating the primary excitatory pyramidal neurons activity in the PFC. Indeed, individuals who have deficits in these INs, a common feature in many mental disorders, often fail to adjust their behaviour to a rule change, even though their ability to learn an initial rule remains intact. The two, main IN subsets, Parvalbumin-positive (PV) and Somatostatin-positive (SST) have different anatomical and physiological characteristics suggesting distinct functions. We, thus, hypothesize distinct roles for each subtype: PV cells may control the gain in pyramidal neuron activity, thereby affecting behaviour. SST cells, however, may control the ability to learn a new rule via plasticity in dendrites, thereby affecting behaviour, but leaving pyramidal neurons activity intact. Combining genetic, imaging and behavioural techniques in freely moving mice with in silico studies, we will dissect the effects of of long-term dysregulation of PV and SST INs on the PFC circuit function, with respect to flexible behaviour. Our experimental results will be fed to a computational model of the PFC circuit to further investigate how interneuronal control of information affects cognitive flexibility and to explore mechanisms that can reverse cognitive flexibility defects. Unravelling the mechanistic role of cognitive flexibility in the PFC will not only further ou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Awareness Raising and capacity building Increasing ADoption of EGNSS in urbaN mobility Applications and services' (ARIADNA), addressing dissemination and exploitation.

assistant: **Impact**

Urban mobility is becoming an issue of great importance in today’s society due to the increasing population movements towards big cities and the exponential growth of cities in developing countries. Today, urban mobility schemes are evolving faster than ever mainly due to social, economic and technological changes. The traditional choice between walking, taking public transport or else buying a car is being extended with a wide range of new flexible mobility services, such as vehicle sharing and ride-hailing. Those shared mobility services are blurring the lines between private and public transport, with the potential of displacing car ownership but also traditional transit systems. And the adoption of autonomous vehicles will only accelerate this trend. There's the need for Public Transport Authorities, operators and industrial providers to prepare for this change and adopt the necessary tools to manage the mobility services of the future in a more flexible and efficient way.EGNSS has the potential to enhance the quality of public transportation, by reducing operational costs, reducing traffic and providing savings in time and fuel, while fostering the development a wide range of new shared mobility services. ARIADNA aims at supporting the adoption of EGNSS for Public Transport and urban mobility, by raising awareness on GALILEO and EGNOS benefits among the different stakeholders involved and supporting the introduction of new solutions provided by SMEs and start-ups. The project builds up on experience gained from previous R&D related projects and the extensive network of stakeholders that can be reached through UITP and EIT Urban Mobility networks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Investigations in molecular and cellular model systems, in transgenic animal atherosclerosis models and in humans' (1994-1998).

assistant: **Concept**

Objectives- Investigations on the patho-physiological importance of enzymatic and nonenzymatic oxidation of LDL in atherogenesis - To study the mechanism of oxidative modification of LDL in molecular and cellular systems, in transgenic animal atherosclerosis models and in humans. - To investigate the regulatory effects of oxidised LDL on gene expression in various cellular systems as well as its impact on foam cell formation.Brief description:Oxidation of LDL converts the lipoprotein to an atherogenic form which is rapidly taken up by macrophages to form lipid laden foam cells. The aim of this Concerted Action is to throw light on the in vivo mechanisms of LDL oxidation and to clarify the impact of oxidised LDL on cell physiology. Because of complexity of LDL oxidation in vivo it is intended to study this process in molecular and cellular model systems, in transgenic animal atherosclerosis models and in humans. On the molecular level LDL oxidation will be studied in enzymatic and non-enzymatic model systems with respect to structural and functional alterations of the LDL particle. Computer assisted modelling of LDL oxidation kinetics may lead to a more comprehensive understanding of the pro- and anti-oxidative processes involved. On the cellular level the mechanism of cell mediated LDL oxidation and the metabolic effects of oxidised LDL will be investigated in macrophages, endothelial cells and smooth muscle cells. Moreover, the impact of lipid metabolising enzymes on lipid deposition during in vitro foam cell formation will be studied. On the level of whole animals research will be focused on the assessment of early atherogenesis in transgenic mice atherosclerosis models. Cross breeding of established transgenic animal atherosclerosis models (apo E-knock out mice, LDL-