RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrable families of nonlinear partial differential and difference equations and their reductions.' (1998-2002).

assistant: **Innovation**

The project proposed here is part of basic research of fundamental importance in applied mathematics and theoretical physics and the objective is to contribute to the common solid basis of the above scientific fields provided by the integrable systems. More precisely, we propose to study the mathematical structures underlying integrability of novel families of nonlinear PDEs and difference equations which are associated with the hierarchies of prime solution equations like the KdV equation and are introduced recently by members of the research group at the host institution. The connection of these PDEs with integrable equations describing the gravitational interaction within the context of Einstein's General Relativity is one of the main results of the applicant Ph.D thesis. Taking advantage of this common scientific ground achieved independently by the work of the scientist in charge and the applicant we shall investigate further these novel equations and expand the results within the framework of the ASDYM equations. Using group-theoretical techniques we shall consider the reductions of both families of partial differential and difference equations and elucidate how these powerful techniques which apply to continuous equations may also be applied to their discrete counterparts. The results would clarify how integrable systems arise from above (ASDYM equations) and form below (lattice equations) and-their in-between reductions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improvement of symbiotic nitrogen fixation in Chinese soybean cropp ing areas' (1994-1998).

assistant: **Innovation**

The main objectives are defined as follows :* To carry out quantitative analyses of the Sinorhizobium fredii and Bradyrhizobium japonicum populations in soils of four different Chinese soybean cropping areas. It will be determined the density (bacteria / gram of soil) of indigenous populations of S. fredii and B. japonicum and a collection of these bacterial strains will be made.* To determine the importance of pH as a key factor in determining the final outcome of the competition for soybean nodulation between S. fredii and B. japonicum.* To analyze the symbiotic capacity of different Western and Asiatic soybean cultivars in order to determine the best pairs soybean cultivar-inoculant strain.* To isolate S. fredii and B. japonicum strains that are highly effective and / or competitive as soybean inoculants.* To investigate the symbiotic properties of Sinorhizobium meliloti strain 042B. This bacterial strain has recently been isolated in China and it is able to nodulate effectively on both alfalfa and soybean plants.Expected OutcomeA collection of S. fredii and B. japonicum strains isolated from Chinese soybean cropping areas will be available. New S. fredii and / or B. japonicum strains showing high symbiotic capacity with soybeans will be available. The expected result will be the isolation of soybean microsymbionts that when they are used as soybean inoculants, produce an increase of the soybean yield. The effect of pH on the competition for soybean nodulation between S. fredii and B. japonicum strains will be determined. S. meliloti 042B nodulation genes that determine specific nodulation in alfalfa and / or soybean will be studied. The structure of the nod factors produced by S. meliloti strain 042B will be known.The key activities involved :* Soil samples from fou
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Metamaterial Interfaces for Quantum Electronics' to be submitted under Horizon Europe.

assistant: **Abstract**

The quest to design materials with tailored properties is a driving force for new scientific and technological horizons and is critical for addressing the grand challenges of humanity. Our proposal introduces an innovative concept in condensed matter and materials science: heterostructures built upon the fusion of 2D van der Waals materials and freestanding transition metal oxides (TMOs), forming a new compound metamaterial where the interface itself plays a crucial and active role in the properties and functionality.  Our strategy is threefold. First, by incorporating a 2D layer between two TMO crystals to prevent ionic-covalent bonding and disorder, we can stack the TMOs with a continuous, free choice of twist angle. This will dial in interfacial superstructures called moiré lattices, which impose profound changes in their physical properties. Second, the moiré lattices will ‘imprint’ ferroic orders in the interfacial 2DL, which then act as a spacer, lubricating layer, and sensing layer in one. Moiré engineering has so far been reserved for van der Waals materials, and with METRIQS, we seamlessly merge TMOs with van der Waals materials, creating a highly versatile hybrid platform, where the interaction strength, strain, and dislocation networks can be controlled. Moiré metamaterials are used to study valleytronics and correlated states, control skyrmions, realise spin-charge conversion devices, and control the nucleation of chiral molecules.  Our most ambitious endeavour unfolds in the third phase, where we are committed to revolutionising material synthesis by design. This will be achieved through interface manipulation, employing a combination of static and dynamic techniques, including strain, light, and electric/magnetic fields, in conjunction with the precise con
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Autonomous Cellular Computers for Diagnosis' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for multiplexed diagnosis using the non-pathogenic bacterium Bacillus subtilis.In a first research line, I will conceive a scalable detection machinery by engineering chimeric receptors detecting extracellular biomarkers via sensing domains derived from antibodies. In a second research line, I will implement bio-molecular computing systems operating within and across bacterial cells to perform multiplexed biomarkers analysis. I will deploy in B. subtilis biomolecular logic gates and will engineer specific cell-cell communication systems to perform distributed multicellular computation in a bacterial consortia.My project is highly interdisciplinary and is at the cross-roads of genetic engineering, structural biology, biophysics, modeling, and clinics. On  foundational point of view, I will make several breakthrough contributions to synthetic biology: (i) Advancing engineering frameworks for the Gram-positive model, B. subtilis. (ii) Pushing the limits of custom-ligand detection by engineered cells (iii) Exploring the frontiers of man-made biological computers. On an applied point of view, I plan to deliver a first prototype for the urinary diagnostic of diabetic nephropathy, a major complication of diabetes. Because of the modular design principles applied, my sensing platform will be re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multianalyte Continuum Nanopores Sensing' under Horizon Europe.

assistant: **Concept**

Diagnostic limitations in healthcare form a major societal challenge, especially in the case of heart failure. More than 15 million Europeans suffer from heart failure, with a projected increase of up to 33% in heart failure patients globally by 2060. An important instrument for better diagnoses of heart failure comes from natriuresis-guided therapy, offering potential for personalized treatment. Monitoring natriuresis through urinalysis via Point of Care Testing (POCT) helps manage severe heart failure. However, POCT presents several complications, as it can only be performed by health care professionals and long-term costs are high. Responding to these challenges, this ERC Proof of Concept (PoC) proposal introduces ""Multianalyte Continuum Nanopores Sensing"" (MC-Nano), led by Prof. Giovanni Maglia. MC-Nano aims to develop a biological nanopore tool for real-time continuous patient health monitoring to improve possibilities of POCT. MC-Nano will develop a nanopore system to detect sodium ions, electrolytes, proteins, and heart failure biomarkers in liquid samples like urine. By utilising multiple nanopores, the system improves accuracy and reliability in identifying pathologies related to heart failure, including kidney failure. The project's advantages include its potential for miniaturisation, minimal need for specialised solutions, and compatibility with low-powered electronic devices. Built upon the foundations of a previous project, ERC CoG De-Nano, which successfully developed biological nanopores for peptide and protein sequencing, this proposal aspires to take the first steps toward the design of an innovative diagnostic device tailored for continuous monitoring of heart failure patients, tracing natriuretic activity in real-time. The resulting technology aims
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'ENzymatic DEcontamination TECHnology'.

assistant: **Concept**

Human activities are associated with increasing amounts of waste that ultimately find their ways into European waters and have negative consequences on the environment. With the background of an aging population and increasing urbanization, wastewater treatment must specifically target pharmaceutical products (PPs) and endocrine disrupting chemicals (EDCs) so that these highly biologically-active compounds are eliminated from the water resource.If conventional treatment technologies are very efficient on a large number of compounds, some chemicals, such as pharmaceutical residues and endocrine disruptors, are recalcitrant and are not removed. The chronic exposure to these compounds is a topic of threat as the long term effects are so far unpredictable and undocumented. This issue has recently drawn the interest of many medical professionals, eco-toxicologists and environmental and health agencies.The global objective of the ENDETECH program is to develop a technology which aims at eliminating persistent pharmaceutical pollutants in wastewaters originating from drug manufacturing sites, households, hospitals and animal farms, thanks to an innovative ENzymatic DEcontamination TECHnology.The pharmaceutical pollutants targeted in priority during this project will be antibiotics, hormones and endocrine disruptors.The ENDETECH program is articulated around three main steps: (1) enzyme libraries will be screened to identify novel enzymes able to inactivate the selected pollutants; (2) the discovered enzymes will be immobilized on beads or membranes and subsequently (3) used in bioreactors to decontaminate waste effluents.The ENDETECH consortium includes all the needed and complementary skills for the project in the fields of enzyme screening, optimization and immobilization, b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Ultra Novel and Innovative Fully Integrated Engine Demonstrations'.

assistant: **Concept**

The journey to climate-neutral aviation will require the power density of an ultra-efficient gas turbine combined with SAF, all highly integrated into an advanced aircraft platform for the SMR aircraft category. As the Clean Aviation SRIA states, this SMR aircraft category generates approx. 50% of the current share of air transport emissions, demonstrating the importance of the focus that is required on propulsion technology. The UNIFIED project will develop and demonstrate UltraFan®, a high performance scalable UHBR ducted turbofan to a TRL5 maturity level, targeting a 20% fuel reduction for SMR aircraft anticipating 2035 EIS. This TRL5 will be achieved via the project enabling technologies and enhancing design to deliver a full engine ground test at SMR thrust class.UNIFIED will importantly progress readiness for  UltraFan Flight Test Demonstration including flight test vehicle design, flight test instrumentation and engine flight clearance readiness. Within this preparation, testing of the UltraFan Key Architecture will be conducted to generate evidence for Flight clearance.  In parallel to the focus on demonstration and flight test preparation UNIFIED will create strong foundations for EIS.  The consortium looks forward to working with EASA, progressing the CRL of the UltraFan architecture and technologies.  Also, engagement with Lufthansa Technik will provide strong insight on the MRO aspects that will be critical to the successful deployment of UltraFan into the SMR sector. The activities of UNIFIED, led by Rolls-Royce, will bring airframer, suppliers, academics and research centres all strongly integrated within the UltraFan Programme.  Synergies will be leveraged with the comprehensive national and regional programmes across the consortium that enable technology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Integrating Punching and Laser Coil Technology for Metal Manufacturing Industry'.

assistant: **Innovation**

PRODUTECH S.r.l. is an Italian company specialized in metal sheet working machines, which counts on more than 20 years' experience in innovative machines production. With continuous innovation efforts, PRODUTECH is a notable actor on the global market with 166 customers in Europe and 22 customers outside the EU (India, North America and Far East), thanks to a worldwide distribution network. EffiCOIL represents a key business opportunity following the successful Phase 1 execution of the SME Instrument.Industrial activities are responsible for more than one fourth of the total energy consumption in Europe. In particular, the metallurgical industry is responsible for about 20% of such energy expenditure, summing up to about 51Mtoe per year. In this context, metal forming machines are used in a wide range of discrete production areas, including white goods, steel furniture, lighting and electrical equipment, automotive, etc. However, at moment, no solutions are available in the market offering a complete integration of the metal forming process, including electric punching, fibre laser cutting and direct coil feeding. With EffiCOIL project, PRODUTECH will get ready for the market launch of a new machine for metal coil working, combining the flexibility of coil metal punching – process already patented by PRODUTECH - with the precision and speed of the coil fibre laser cutting - first brought to market by PRODUTECH. The integrated technology will result in a 52% reduction in energy consumption for metal sheet production, as well as 20-30% reduction in wasted metal sheet, with a decrease in Capex and Opex versus standard metal processing machinery. The expected profitability will be high (TIR~23%). For PRODUTECH, EffiCOIL market launch will allow an optimization of the busine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Manipulating Hypoxia Inducible Factor (HIF) activity in the adipose cell. A means of altering cell differentiation and metabolism ?' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

In most individuals, the adipose tissue, like other adult tissues, maintains a stable mass. Nevertheless, this tissue displays a unique capacity to grow or regress during adulthood, when energy balance shifts positively or negatively. In humans, phenotypes of adipose dystrophy range from massive obesity, where adipose mass represents 60 to 70% of body weight, to lipoatrophy, with less than 2% of fat. Starting during the past 10-20 years, the number of obese individuals is increasing on an epidemic scale wor ld-wide. The clinical problem of excessive adipose tissue mass resides in its strong association with a number of life-threatening conditions: hyperlipidemia, high blood pressure, glucose intolerance and diabetes, coronary heart disease and some types of c ancers.The main cellular components of adipose tissue are adipocytes. It is now recognised that these cells are at the heart of a complex endocrine and paracrine network, which substantially influences the whole organism. Dysregulation of adipose cell mass induces profound alterations of the cell\'s metabolic properties and hormonal responsiveness, leading to alteration in adipose-derived circulating factors. These defects have been causally implicated in several obesity-related co-morbidities.We and others have recently revealed that adipose differentiation, metabolism and secretory function are sensitive to hypoxia and that Hypoxia Inducible Factor (HIF) activation underlies several ol these responses. Here, we propose to investigate the genomic and phenot ypic effects of modulation of HIF activity in the adipose cell. At the cellular level, the effect of genetic and pharmacological activation of the HIF system on adipose gene expression and metabolic activity will be studied in the mouse 3T3-L1 pre-adipose cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'New genetic techologies: application to generate attenuated malaria vaccines' in the context of a Fifth Framework call.

assistant: **Objectives**

Malaria vaccines are urgently required. Recombinant multi-component cocktail vaccines are currently favoured. Using very recent technological advances this programme revives the concept of attenuated parasites as vaccines. It bring together for the first leading EU and African groups to develop methodologies allowing the design and creation of parasites with properties desirable in such a vaccine. The ultimate delivery of such a vaccine may be as either sexually incompetent, genetically restricted parasites, or as transmissible self-spreading forms. For either route certain fundamental pre-conditions must be met, and these are the major focus of this proposal; Systems will be developed to provide1) auxotrophic parasites2) sequential unrestricted genetic manipulation of parasites3) axenic culture4) parasite knock outs for specific genes and5) immuno-potentiated parasites through heterologous gene expression. In combination with a dialogue across scientific and public interests this programme will enable the partnership to provide a clear assessment of the feasibility of vaccination with genetically modified malaria within three years.