RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Analysis of natural-genetic variation controlling the timing of GIGANTEA expression in Arabidopsis'.

assistant: **Concept**

The circadian clock regulates many physiological and developmental processes in plants. The GIGANTEA (GI) protein plays a major role in the clock mechanism and controls important clock outputs including photoperiodic flowering. GI expression follows a circadian rhythm, with a peak in the evening, and changes in the timing of GI expression have dramatic effects on biological programs such as flowering. Natural-genetic variation in the timing of circadian-clock-controlled-gene expression is important in the adaptation of plants to growth at different latitudes both in nature and in agriculture. This project proposes to identify the molecular basis of natural-genetic variation that causes differences in the timing of GI expression between accessions of Arabidopsis. The three major objectives are (1) to map QTL implicated in the control of GI expression (2) to isolate the gene underlying at least one of these QTL and thereby identify a new gene, or natural allele of a known gene, that alters the timing of GI expression (3) to initiate the functional characterization of the identified GI regulator. To reach these objectives 85 Arabidopsis accessions were originally transformed with a GI::Luciferase transgene and several of them showed differences in the timing of GI expression compared to the reference accession Col. Two of these lines were crossed with Col and study of the F2 progeny demonstrated wide variation in the timing of GI expression. The results support the feasibility of the objectives, and these populations will be used in this program to identify QTL. Training on the study of natural variation will take place at the Max Planck Institute in Cologne and will complement the researchers existing skills in molecular biology. The technical expertise gained, the materi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Parallel Numerical Linear Algebra for Future Extreme-Scale Systems' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The NLAFET proposal is a direct response to the demands for new mathematical and algorithmic approaches for applications on extreme scale systems, as identified in the FETHPC work programme and call. This project will enable a radical improvement in the performance and scalability of a wide range of real-world applications relying on linear algebra software, by developing novel architecture-aware algorithms and software libraries, and the supporting runtime capabilities to achieve scalable performance and resilience on heterogeneous architectures. The focus is on a critical set of fundamental linear algebra operations including direct and iterative solvers for dense and sparse linear systems of equations and eigenvalue problems. Achieving this requires a co-design effort due to the characteristics and overwhelming complexity and immense scale of such systems. Recognized experts in algorithm design and theory, parallelism, and auto-tuning will work together to explore and negotiate the necessary tradeoffs. The main research objectives are: (i) development of novel algorithms that expose as much parallelism as possible, exploit heterogeneity, avoid communication bottlenecks, respond to escalating fault rates, and help meet emerging power constraints; (ii) exploration of advanced scheduling strategies and runtime systems focusing on the extreme scale and strong scalability in multi/many-core and hybrid environments; (iii) design and evaluation of novel strategies and software support for both offline and online auto-tuning. The validation and dissemination of results will be done by integrating new software solutions into challenging scientific applications in materials science, power systems, study of energy solutions, and data analysis in astrophysics. The deliverables a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Functional analysis of inhibitory microcircuit in zebrafish olfactory forebrain - by combining viral tracing of synaptically connected microcircuits with neuronal activity measurements' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Interneurons in olfactory cortex, central importance for the function of cortical circuits, comprise a wide range of different cell types that may be involved in different microcircuits and computations. However, the fine architecture of synaptic microcircuits which support computational processing in cortex is still poorly understood. The aim of this project is to address connectivities and functions of inhibitory microcircuit in the olfactory system by combining viral tracing of synaptically connected microcircuits with neuronal activity measurements in the intact zebrafish brain. First, I will ask whether different types of interneurons define specific microcircuits by mono-synaptic virus tracer and electrophysiology. To explore the detailed and quantitative data on connectivity motifs in olfactory cortex, I will then visualize microcircuits from single starter interneurons using Gal4-UAS system and DNA transfer to single neuron. Using this visualized microcircuit from single starter cell, I will also ask the physiological characters of each microcircuit by measurement of odor responses by 2-photon imaging. Finally, I will provide direct insights into the computational functions of synaptic microcircuits using optogenetics to manipulate the connected presynaptic neurons. These experiments will uncover general design principles of inhibitory microcircuit that will help to understand relationship between circuit structure and their function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'My Personal AI Mediator for Virtual MEETtings BetWEEN People' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

In a world of increasing preoccupation with artefacts, interacting with our fellow human beings remains one of our most enjoyable, but also one of our practically most critical activities. We derive inspiration from each other, solve problems and chart our future together. Yet our interaction with fellow humans is far from seamless or frictionless: despite much greater world-wide reach, we suffer (perhaps more than ever) from isolation, barriers and separation due to language, culture, physical distances, time-zones, scheduling conflicts, and distractions to our attention. With greater freedom, reach and flexibility, our isolation and complexities also appear to increase. In our proposed project “Meetween”, we aim to find solutions to these problems. Rather than artificial intelligence (AI) getting in the way of the human experience, we harness its power to make human-human interaction more seamless and natural, eliminate language barriers, replace the techno-clutter with support. The project aims to 1) build the science-based technology solutions needed to power the next generation of videoconferencing platforms for Europe, to support smooth, engaging, barrier-free collaboration across languages; 2) exploit the all-round, integrated algorithmic capabilities offered by foundation models and self-supervised training on large datasets to nimbly adapt to participant context, cultural and regional specificities, including linguistic ones; 3) foster and facilitate business collaboration throughout the European Union by providing real-time machine-learning-powered speech-to-speech translation, summarization and virtual assistant services for online meetings; 4) defend a European vision for AI with regard to safety, privacy, social and ethical approaches, anchored in our regul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DNA helicases in genome maintenance: from molecular and cellular mechanisms to specific inhibitors as potential drugs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Helicases are ubiquitous enzymes, found in viruses, Bacteria, Archaea and eukaryotic cells. They act as motor proteins to separate or remodel DNA or RNA duplexes, using ATP as an energy source. Helicases play a key role in a variety of cellular processes, including DNA replication/repair/recombination, as well as RNA translation and transport. They are emerging as an important class of targets for antiviral, antibiotic and anti-cancer drugs. To date, several genetic and biochemical studies have revealed the molecular and physiological functions of DNA helicases. Moreover, protein three-dimension structural studies coupled with single molecule biophysical approaches have provided insights into structure-function relationships and reaction mechanisms of some key DNA helicases. With a consortium including experts with complementary competence and expertise in Physics, Chemistry, Biology and Clinical Oncology, and a strong commitment of companies involved in drug discovery or in the development of state-of-the-art biophysical instrumentation, we aim to: 1. obtain a detailed picture of the mechanism of action and the physiological role of a number of DNA helicases that are implicated in human diseases; 2. discover specific inhibitors of those enzymes, which can then be tested as novel therapeutic drugs, especially for cancers; 3. address the need for training next generation scientists with complementary approaches and diverse techniques by secondments in different laboratories of the consortium; 4. promote a culture of collaboration between academic and private sectors and provide young scientists with the necessary experience and skills to exploit the full potential of research findings; 5. provide early stage researchers with greater opportunities to access an increasingl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Air Transport Net (AirTN)', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The AirTN ERA-Net was established under FP6 as a network of Member States whose ministries and agencies manage public funded national research activities and programmes in Aeronautics and Air Transport. The results from AirTN in FP6 are prerequisites for the implementation of joint activities to enhance co-operation and coordination of national and regional research programmes. AirTN in FP7 will strengthen this coordination and strive for long lasting co-operation. It will bring added value to the foundation of the European Research Area and the development of a European Research Policy, especially in relation to aeronautics and air transport. The focus will be on the Implementation of Joint Activities and the funding of transnational research. The governing objective of all AirTN activities is to continue strengthening the European Research Area within the framework of the ACARE Strategic Research Agenda.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploitation, Promotion and Support for Integrated Machine Vision' (EXPANSIV) targeting Fifth Framework.

assistant: **Abstract**

This project is an accompanying measure to promote the uptake and exploitation of an innovative new technology (integrated machine vision) to make European business more competitive. This measure accompanies EUTIST-IMV (IST-1999-20188)which is a cluster of Take-UP actions with a common theme of machine vision. This accompanying measure will promote the results of EUTIST-IMV through a series of focussed dissemination and exploitation actions. Best practice for dissemination has been established by earlier IST activities, and this will be applied in the proposed work. This project is an accompanying measure to promote the uptake and exploitation of an innovative new technology (integrated machine vision) to make European business more competitive. This measure accompanies EUTIST-IMV (IST-1999-20188), which is a cluster of Take-UP actions with a common theme of machine vision. This accompanying measure will promote the results of EUTIST-IMV through a series of focussed dissemination and exploitation actions. Best practice for dissemination has been established by earlier IST activities, and this will be applied in the proposed work.OBJECTIVESThe objectives of EXPANSIV are:The objectives of the EXPANSIV project are:- To raise awareness among potential new end-users and exploiters of the benefits of integrated machine vision (IMV);- To be the bridge between technology suppliers and those who will deploy technology;- To encourage wide uptake of technology across EUTIST-IMV cluster;- To identify and fully exploit synergies between the activities in EUTIST-IMV;- To ensure the wide deployment of IMV best practice throughout European industry;- To stimulate and broaden the technology transfer activities of the IMV-NET partners.DESCRIPTION OF WORKThe proposed work is an Accompanyi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Green Aviation – Lean Arrivals And Dynamicity' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The GALAAD Green Aviation  Lean Arrivals And Dynamicity project proposal contributes to the SESAR 3 IR Aviation Green Deal topic.The project proposes to develop and validate a concept for dynamic RNP route allocation in the terminal area in order to make ATC operations more sustainable, resilient, responsive and adaptative towards operational condition changes and traffic demand variations. The research addresses the development of the end-to-end concept, including relevant decision support tools evolution and cross-border aspects. The idea is to move away from fixed RNP arrival route stuctures towards a flexible approach able to provide agile responses to variations of operational conditions in the terminal area, such as traffic density, airspace availability or environmental/weather constraints, and to develop the best eco-friendly routes structures.As operational improvements, the introduction of the GALAAD-proposed concept related to a dynamicity in the use of RNP route structures within the terminal area is expected to provide greater fuel efficiency and environmental sustainability without negatively impacting capacity while improving safety and cost efficiency.


**Keywords:** Green, RNP, Sustainability, AMAN, Dynamicity, Digital, Resilience, Aviation, SESAR
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Structural and functional biodiversity of humic matter degrading freshwater microbial communities' in the context of a Seventh Framework call.

assistant: **Objectives**

Humic substances (HS) are complex and heterogeneous mixtures of polymers formed in soils, sediments and natural waters during the decay of plant biomass. HS represent an important carbon source in aquatic environments accounting for up to 80% of the total dissolved organic carbon (DOC). Historically, HS were considered to be biologically inert but discovery of the “microbial loop” changed this view in which DOC enters planktonic food webs through incorporation into bacterial biomass and protozoan grazing upon bacteria.Despite extensive research it is still not clear how exactly HS are converted and degraded by microorganisms in nature. We particularly lack a detailed understanding of the metabolic diversity present in a community that is used to attack the complex structure of these heterogeneous polymers. Based on current structural concepts it is assumed that HS cannot be degraded by simple enzymatic reactions but rather by a combination of different enzymes including peroxidases, phenol oxidases and many carbohydrate active enzymes.The proposed project aims to resolve the genomic and metabolic diversity of freshwater microbial communities involved in HS cycling using state of the art sequencing-based approaches. Metagenomic and metatranscriptomic approaches will be used to perform in-depth genomic analysis of freshwater microbial communities and to study their physiological response to HS based on gene-expression analysis. Different habitats and ecological niches will be sampled and analyzed to enable detailed comparative analysis (e.g. aerobic vs. anaerobic habitats).Considering the environmental and economic importance of HS it is very important to understand mechanisms involved in HS cycling in nature. The proposed project will provide the scientific community wit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Consortium in Healthcare Outcomes and cost-benefit research' to be submitted under Seventh Framework.

assistant: **Abstract**

ECHOUTCOME is an interdisciplinary European research platform with the aim of assessing methodological properties of Healthcare Outcome and Cost-Benefit studies. The ECHOUTCOME consortium is composed by eight partners from 4 countries including three academic international experts in Outcome Research from, the French Scientific Society in Health Economics, the European office of one Multinational BioPharma industry, two research organisations (SME) specialized in advanced statistics and modelling and one organization specialized in international research administration. The general objective of this consortium is to study European health systems in order to assess decision making criteria in the frame of national needs and expectations across member states concerning healthcare outcomes and cost-benefit analyses Using both the descriptive and the experimental approaches, the ECHOUTCOME consortium will be able to investigate the relationship between quality of care with costs, efficiency and accessibility by indentifying and assessing existing approaches, but with the capability to develop new approaches for Decision Making purpose. Considering the fact that some Health agencies in Europe such as the National Institute of Clinical Excellence in the UK has published a guidance recommending one specific outcome (Quality Adjusted Life Years) and one specific Cost Benefit approach (Cost per Quality Adjusted Life Years) as a requirement for population access to innovative health technologies, it is urgent that the European Union considers the properties and consequences to use one reference case, before spreading or recommending any specific approach in other member states. ECHOUTCOME will allow to make major advancements to improve the knowledge about Health Systems organiza
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'BoneScreen: Opportunistic Osteoporosis Screening in Computed Tomography' (BoneScreen) targeting Horizon 2020.

assistant: **Abstract**

Worldwide, an osteoporotic fracture occurs every three seconds; most of them in Europe, where the economic burden has been estimated at €37 billion per year and lost years of life surpass most major cancers. This is hard to comprehend, given that osteoporosis is a preventable, treatable disease, if diagnosed at an early stage. As current state-of-the-art screening methods are neither sufficiently available nor accurate, there is an urgent need for readily available and accurate screening systems. BoneScreen will fill this gap and provide a low-cost and accurate screening method, available for millions of patients. BoneScreen introduces a fully automated solution to evaluate existing computed tomography data of patients. BoneScreen will calculate volumetric bone mineral density (vBMD), the most reliable and accurate single predictor of a patient’s fracture risk. In contrast to existing methods, BoneScreen is fully automated; it is purely non-invasive and excludes any additional radiation dose or patient discomfort; it is fully calibrated, yielding high precision and allowing for the application of established diagnostic categories; it works for all vertebral levels, allowing for inclusion of scans with variable coverage. Additionally, the functionality of BoneScreen is easily extendable, e.g. for detecting fractures or metastasis.The overall goal of this proposal is to initiate the start-up process for a company commercializing the research developments to date. Specific objectives are to (1) increase the technology readiness level of our current research software to reliably work in different hospital environments; in particular we will include an automated calibration, allowing for accurate processing in >98% of cases; (2) increase the awareness of the possibilities pr