RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on '"PRO –SENESCENCE” THERAPY IN PEDIATRIC BRAIN TUMORS""'.

assistant: **Innovation**

The irreversible cell growth arrest, termed cellular senescence, is emerging as an intrinsic tumour suppressive mechanism, which restricts progression of early cancerous lesions in humans. We have recently reported, a new type of cellular senescence, which occurs after the acute inactivation of the tumour suppressor Pten and significantly opposes tumorigenesis in vivo. Pten induced cellular senescence (PICS) occurs at early time points after Pten inactivation even in absence of cellular proliferation and DNA Damage. I will discuss the mechanism that trigger PICS in cancer, hailing the potential therapeutic implication of p53 stabilizing drugs and Pten inhibitors. Importantly, I will discuss how the oncogenic stress induced by complete loss of Pten can still triggers senescence in cells with low proliferative potential, such as cancer stem cells. I propose to apply this model to the treatment of pediatric brain tumors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'GRANULATED RETREADED TYRES FOR SLIPPERY CONDITIONS INCREASED RUBBER RECYCLING AND LESS ROAD WEAR' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The project was concerned with standardising the production methods for granulated tyres (by retreading) and enhancing the production methods for the granules. The granules are of non-specified material and are approximately 1mm in size. New Industries Ltd had developed the core methods and equipment for embedding granules into retread tyres to improve the tyre's road resistance, decrease road wear (in comparison with studded tyres) and promote general recycling of tyres. Further development of this Project involved diverse expertise such as adhesive materials, various granule types, coating methods, design of new production equipment and automation. This process of granulating tyres has been patented.Several tests have been conducted on the concept to verify the characteristics of granulated tyres. At VTI in Sweden, slipping characteristics on wet ice were tested against those of studded tyres and produced very favourable results. Road wear tests performed in Germany showed that granulated tyres wear the road 14 times less than an average of nine different studded tyres. In Iceland noise from granulated tyres was compared with noise from studded tyres and regular tyres, where it was verified that noise levels from a car driving on granulated tyres are similar to those from regular tyres but significantly less than the noise levels from a car driving on studded tyres. In addition to the above tests, extensive user tests have been going on since the beginning of test production in 1994.Partners in this project with New Industries were Vacu-lug Traction Tyres of England. They manufacture retread truck tyres and almost any tyres for non-commercial vehicles and applications ranging from small fork-lift tyres to large earth-mover tyres. They intended to use the technique for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis' (FOLSMART).

assistant: **Innovation**

FOLSMART will bring to phase I clinical trials novel folate-based nanodevices (FBN) for the treatment of rheumatoid arthritis (RA). These nanodevices for folic acid (FA)-mediated targeting of activated macrophages showed improved clinical scores in a mouse model of RA when compared to methotrexate (MTX), first-line drug therapy for the treatment of RA. In this way, FBN will be benchmarked against this drug. MTX has significant associated toxicity and second-line biological therapies pose a great economic burden to hospital/public health systems. In parallel, nanodevices encapsulating Sulfasalazine (SSZ), will be tested. SSZ is a second line indication for the treatment of RA, unresponsive to MTX or MTX–intolerant patients. Furthermore, FOLSMART proposes the optimization of mechanisms for the release of the drugs, through pH and temperature-sensitive nanodevices. Exploitation and business plans will be elaborated. In parallel, the initial economic evaluation of all proposed treatments will be performed to validate these claims.Specific technological objectives of FOLSMART will be:Good Manufacturing Practice (GMP) production of the FBN based therapies which have been positively bench-marked in the previous FP7 European project NANOFOL in comparison with the use of MTX in a RA mouse model: -Liposomal MTX and SSZ with FA-“neck domain” peptide as targeting agent-Nanoparticles from HSA-FA/MTX conjugates and SSZ-Optimization of mechanisms of drug release and application to other fieldsPre-clinical development  on RA models:-Toxicology and pharmacokinetics, to determine tolerability and efficacy benefit in two animal models rat and dog, under Good Laboratory Practice (GLP) standards-Genotoxicity and CarcinogenicityPreparation for Phase I clinical trial of the best therapies ben
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'CyanoKit®, the fastest and easiest test for reliable on-site cyanide detection.' (CyanoKit).

assistant: **Concept**

With more than 1.1M tons of cyanide produced annually worldwide, the widespread use of cyanide in industrial processes, coupled with the limitations of current analysis and monitoring technologies, raises serious concerns regarding public safety and environmental protection. In fact, over the past 25 years more than 30 major accidents involving cyanide spills have been reported worldwide. In this context, simple, reliable and affordable cyanide tests can help industry managers effectively address cyanide management and protect the environment and human’s safety.CyanoKit® is the first test kit with a technology that allows the naked-eye detection of free cyanide in water, soil and food extracts on-site, right where the source is. This innovative technology eliminates the use of hazardous chemicals and the need for specialised laboratory instrumentation, making CyanoKit® suitable for a wide range of users, not only specialised technicians. CyanoKit® detects cyanide faster than available methods (in less than 60 seconds), is highly selective and allows for customized detection thresholds, bringing to the market a tailored, semi-quantitative test for rapid free cyanide detection.So far, we have invested €300K into the development and assessment of our test to ensure its robustness and efficiency before moving into the commercialisation stage. To further develop CyanoKit®, overcome market barriers and deploy it at a European and global level, we need a further investment of €2.2M, which will allow us to set up a solid EU value chain able to meet the large demand expected during the first commercialisation years. This will eventually ease our access to new markets, such as the healthcare industry.The proposed work in Phase 1 of the SME instrument fits into our overall plan to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Controlling gene integration: a requisite for genome analysis and gene therapy' (GENINTEG), addressing dissemination and exploitation.

assistant: **Impact**

Despite the enormous potential of using transgenesis for gene function analysis and gene therapy, little is known about mechanisms of gene integration in eukyotic cells. Transgene integration into the chromomsomes of living cells can occur either randomly or targeted by homologous recombination. The later type of integration is the most useful, because it allows precisely deleting or modifying sequences at defined chromosomal positions. A consortium is formed to study gene integration by recombination in a number of different model organisms.As DNA repair is conserved during evolution, a comparative genomics approach is proposed to discover evolutionary conserved principles of gene integration. An explicit goal is to understand why targeted integration occurs efficiently in some eukaryotic cells, but not in others. One explanation to be investigated is that the ratios of targeted to random integration reflects to the balance between DNA double-strand break repair byhomologous recombination and end-joining. Other areas of research will relate to site-specific integration by AdenoAssociatedViruses, T-elements, serine recombinases. The insight into mechanisms of gene integration will be used to increase the efficiency of targeted gene integration in cells, where targeted integration events are currently hard to detect. This might be achieved either by modification of the gene constructs, their transfer into the cell nucleus or by regulating the expression of transacting recombination factors. As gene targeting is theonly way to precisely modify the genetic blueprint of living cells in vivo, improvements of this technique offer immense opportunities not only for basic research, but also for biotechnology and gene therapy. This ranges from fine-tuning protein production in p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Polymer conjugation of peptides/salmon calcitonin for increased efficacy' (WBAWBA) under Seventh Framework.

assistant: **Objectives**

This project is concerned with the development of a new peptide conjugation strategy which has the potential to overcome the limitations of the, commercially successful, conventional pegylation with linear polymers. In addition it will explore the application of single electron transfer living radical polymerization (SET-LRP) for this purpose. Project Objectives 1. Synthesis and characterization of α-functional comb polymers by living radical polymerization 2. Hydrolysis studies of polymers and polymer conjugates 3. Evaluation of SET-LRP for synthesis of conjugates 4. Conjugation of polymers to salmon calcitonin 5. Purification and isolation of conjugates 6. Gastric peptide stability testing 7. Use of tryptic digestion to confirm conjugation site(s) 8. In vitro cAMP bio assays for sCT activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Climate-aware Resilience for Sustainable Critical and interdependent Infrastructure Systems enhanced by emerging Digital Technologies' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

ReCharged is a transformative project that has the vision to develop a new integrated framework toward a practical visualisation platform in order to optimise and streamline climate resilience and whole-life carbon emission assessments for interdependent Transport and Energy Systems, Lifelines and Assets (iTESLA). To achieve this, ReCharged harnesses the power of digital technologies and data to quantify the functionality and recovery of iTESLA after hazards. This is in response to the lack of methods of assessment and communicable visualisations of consolidated climate resilience and whole-life carbon emission metrics for iTESLA. ReCharged will account for interdependencies that lead to failure propagation in transport and energy systems, to accelerate post-hazard recovery, mitigate losses and societal ramifications due to climate change. In doing so, ReCharged underpins synergies and participatory decision-making to combat siloed thinking in infrastructure management. This project will lead to 50% faster decision-making in iTESLA management, 50% reduction of carbon emissions for the two case studies analysed, create new jobs, and make Europeans fit for the Digital Age. ReCharged is a synergy that combines the exchange of interdisciplinary knowledge and tailored training of staff, through an alliance between leading academic institutions, industrial partners, SMEs, and a research and technology center. All beneficiaries are committed to exploiting and transferring their skills and knowledge, to incentivise data-driven resilience toward climate adaptation and reduce emissions in critical infrastructure. ReCharged will augment researchers’ skills and career perspectives, create a community of practitioners, improve critical infrastructure, and ultimately make people feel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SyrinJector, the first smart device for livestock mass vaccination.' (SyrinJector).

assistant: **Innovation**

Farm animals are susceptible to different diseases caused by bacteria, viruses, fungi and parasites, just like people.Vaccination protects the welfare of livestock by preventing or reducing disease. These vaccines are licensed and producedunder strict regulatory conditions ensuring their safety, efficacy and quality. The administration of these vaccines is currentlyusing mechanical syringe with needle, an outdated method to deliver vaccines to billions of animals per year.Livestock vaccination is normally performed by hand. However, the accuracy of the operator administering the vaccinedecreases significantly after a couple of hours of automatic and repetitive job, due to the large number of animals injectedper hour. This way, up to 70% of dairy herds are inadequately vaccinated simply because of improper management,according to a study done by the Veterinary Teaching Hospital- Colorado State University. Particularly, the livestock industryrequires a higher levels of vaccination quality to keep up with the growing global demand for higher quantities along withsafe and quality products. Vaccination’s efficacy is dependent on the correct dosage being administered to every singleanimal, in order to create a high and uniform immune reaction.SyrinJector is the first smart syringe gun for the mass vaccination of livestock.The device is fully automated (no mechanicalhand trigger), portable, and works with a software for rapid, controlled and traceable mass vaccination. SyrinJector issafetyconscious(anti-stabbing and needle disinfection mechanisms),and highly accurate, making it a must for livestock farmers.SyrinJector allows high repeatability and reduces human factor and fatigue.Our solution will gradually replace the currentprocess of steel/plastic syringe guns and off-line
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Divergence times, Evolution, and Anatomy Deciphered in early Sharks'.

assistant: **Innovation**

The ancient elasmobranchs (sharks + rays) have the potential to provide great insight into evolutionary processes over large timescales, but this potential is limited by a poor understanding of the relationships between living and extinct groups and the timing of major divergence events. In this project I will address these knowledge gaps by combining new 3D tomographic data on key Mesozoic elasmobranch body fossils with genomic and anatomical data from their living relatives. I will then use this and a dataset of 3D elasmobranch lower jaws to investigate the dynamics of elasmobranch macroevolution, using the rate and mode of lower jaw shape evolution as a case study. In doing so I will build on my existing background in palaeobiology and 3D methods by learning new skills in genomics-based phylogenetics and 3D geometric morphometrics, while developing my skills as a supervisor, communicator, and leader. These new skills, along with the scientific groundwork laid by this project, will give me the tools to pursue an independent programme of research in the longer term, investigating the early evolution of elasmobranchs by combining data from animals both living and extinct.


**Keywords:** Chondrichthyans, Elasmobranchs, Evolution, Palaeobiology, Phylogenetics, Macroevolution, Disparity, Mesozoic, Tip Dating
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Quality, safety and value optimisation of the milk supply chain in rapidity evolving Central and Eastern European markets' in the context of a Sixth Framework call.

assistant: **Objectives**

The purpose of the project is to provide recommendations for the development of internationally competitive milk supply chains in Central and Eastern European countries. They will be made from an evolutionary analysis that will consider the demands of a fa st progress from a centrally-planned to a market-led economy, which will soon be required to compete on quality, safety and value at a par with the Western European supply chain. This objective will be served by a systematic approach that will deploy cutti ng-edge methods of designing supply chains and enterprise resource planning. These provide comprehensive benchmarking tools to effectively pinpoint the impact of various organisational strategies of the supply chain in its distribution of costs and value. This is supplemented by quality and safety best practices suitable for the unique, perishable nature of milk. The project deliverables will support policy-making and strategy decisions to: ensure safety and quality of raw milk in the context of securing pu blic health at competitive costs; optimise the value distribution and improve the efficiency of the supply chain of raw milk to dairy processing in a market-oriented context; cultivate closer cooperation among the stakeholders involved in the agro-dairy se ctor in an enlarged European context; identify strategies to facilitate the evolution of the supply chain of new accession countries safeguarding value and wealth creation in rural economies; identify required scientific knowledge. The work plan comprises: international workshop to develop a blueprint for the benchmarking analysis; missions of the team in countries representative of the various stages of development from centralised to market-led supply chains, gathering data and dissemenating the project t hro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Hydropower For You - Sustainable small-scale hydropower in Central Asia' to be submitted under Horizon 2020.

assistant: **Abstract**

Despite considerable potential to satisfy unmet electricity demand and chart a new way forward in cooperative cross-sectoral management of shared waters, small scale hydropower (SHP) is not extensively exploited in Central Asia (CA). Likewise, vast potential to roll out European SHP approaches in other regions, European technologies have not been widely used due mostly to the lack of adaptation to such contexts; successful test cases are scant as their price point is typically far higher than Asian-manufactured competitors. The Hydro4U project will adapt European technologies to CA, demonstrating viability in a forward-looking cross-border Water/Food/Energy/Climate nexus (WP2) and price-competitiveness through design alterations (WP3) based on a prior analysis of unexploited SHP potential in CA (WP1). Hydro4U will install and assess (WP4) 2 demo plants: 500kW low-head eco-friendly run-of-river plant in KA, 2MW medium-head plant in UZ, both with radically reduced planning and construction costs that do not compromise efficiency. These solutions will be fit-for-purpose based on innovation, modularization, standardisation and radically simplified structural concepts, with longevity, eco-compatibility and socio-political acceptance (WP3). A replication model will be developed to address all SHP potential (WP5). This will demonstrate EU quality standards and create entry points in developing markets for the entire European SHP industry (WP6). Hydro4U brings together a multidisciplinary team (13 partners, 8 countries (DE, AT, CH, LK, ES, BE, CA: UZ, KG, [subsidiary in KZ]) world-renown experts in design of European SHP from industry (GHE, MUHR, HSOL, ILF) to science (TUM, BOKU, KSTU, EV-INBO, SJE, CARTIF), replication (SEZ, CARTIF), exploitation and D&C experts (SEZ), ‘boots-