RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Slow sliding of volcanic flanks as PREcursor to catastrophic COLLAPSE' (PRE-COLLAPSE) under Horizon 2020.

assistant: **Objectives**

The geological record shows that volcanic flank collapses and their associated tsunamis are among the largest and most disastrous natural processes on Earth, because of the huge energies involved. The potential impact of such rare but devastating natural disasters is largely ignored by society, leaving us totally unprepared even to detect the precursors of impending catastrophe. Geodetic monitoring documents gradual (cm/yr) down-sliding of individual flanks at many volcanoes worldwide. Such movements express structural instability, and the majority of volcanoes exhibiting slow flank sliding today have experienced flank collapses in the geological past. There is mounting evidence that such collapses were preceded by slow sliding, leading to the hypothesis that gradual flank movement at some point transitions into collapse. This link, however, lacks a physical explanation, and so identifying which slow-sliding precursors might indicate imminent collapse (and therefore what indicators might be used for hazard mitigation measures) is presently impossible. There appear to be two testable mechanisms by which slow sliding could turn into collapse: (i) it results from decrease in the flank’s shearing resistance, or (ii) enhanced activity in the magma system leads to a run-away feedback situation between sliding and depressurization. PRE-COLLAPSE will test these mechanisms on four volcanoes (Anak-Krakatau, Ritter, Etna, Kilauea) by employing advanced computer models capable of simulating both flank sliding and its interaction with the magma system, incorporating rock mechanical behaviours at shear velocities matching those of slowly sliding flanks, and detailed shoreline-crossing interior structures of the volcanoes based on observational data. The outcome will revolutionize how
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'AQUABUDDY-CARE: A Groundbreaking Solution for Elderly and Disabled people with Reduced Mobility that Finally Enables Caregivers to Effectively and Safely Bathe/Shower them in their own Beds.' to be submitted under Horizon 2020.

assistant: **Abstract**

The progressive ageing of the population is becoming a major problem for society, who sees how ageing comes accompanied by crucial challenges that constraint our healthcare systems. Dependency is one of these challenges, adopting today the form of over 3 million Europeans unable to live independently due to ageing, disease, accidents or long term disability. These individuals rely and depend on caregivers to accomplish daily activities, being hygiene one of the most critical steps. Fulfilling hygiene tasks becomes specially challenging and time-consuming for the saturated personnel at hospitals, clinics or elderly homes, who need to be extra careful with these patients at higher risk of infection. The complexity of the current processes to wash or bathe bedbound patients (which involves transferring the patient out of bed) enters in conflict with the workload pressure faced by caregivers (which limits the time available for each patient). In response, we have developed and validated Aquabuddy-CARE (AQB), a miniaturized and portable shower system that enables patients to undertake hygiene tasks in bed, rapidly and in a dignified manner. The combination of advanced materials, sustainable production process and proprietary water flow system guarantees the efficiency of the technology concerning water consumption and prevention of contamination. After completing the validation at the pilot scale, this project aims to finalise the industrialization and field-testing of AQB. The Feasibility Study planned in Phase 1 will help us secure the project from all technical, financial and commercial standpoints. Once in the market, AQB will bring significant benefits for caregivers and patients worldwide, helping to alleviate the raising impact of ageing and disability while improving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Forest Resource Conservation in Nepal' in the context of a Seventh Framework call.

assistant: **Objectives**

Managing natural resources to sustain human livelihood needs while minimizing the loss of biodiversity and ecosystem services is, arguably, the greatest challenge facing our generation. Top-down approaches to preserve natural resources, e.g. protected areas, have had limited success in integrating local social needs with natural resource management. Local communities use and manage more than 10% of the world’s forests, which are key biomes for biodiversity. Governments and conservation initiatives are increasingly recognizing the role of local communities in natural resource conservation but there is little evidence of how local community needs interact with ecological processes. This fellowship will focus on community-managed forests and investigate, for the first time, how long-term environmental outcomes influence - and are influenced by - community management practices. To address this issue, the candidate fellow Dr. Johan Oldekop, will focus on a series of community-managed forests in Nepal and lead an interdisciplinary collaboration between Dr. Mark Whittingham at Newcastle University (UK), and Prof. Arun Agrawal and the International Forestry Resources and Institutions Programme (IFRI) at the University of Michigan (USA). Research outcomes will be highly relevant for forest management policies globally (including community management initiatives in European forests). By leading a high-impact interdisciplinary and policy relevant research programme, Dr. Oldekop will master a unique set of complementary skills and position himself at the lead of interdisciplinary socio-ecological research. Becoming one of Europe’s first uniquely trained interdisciplinary conservation scientists will allow Dr. Oldekop to establish new international collaborations and significantly e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Hydrophobic Gating in nanochannels: understanding single channel mechanisms for designing better nanoscale sensors' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Hydrophobic gating is the phenomenon by which the flux of ions or other molecules through biological ion channels or synthetic nanopores is hindered by the formation of nanoscale bubbles. Recent studies suggest that this is a generic mechanism for the inactivation of a plethora of ion channels, which are all characterized by a strongly hydrophobic interior. The conformation, compliance, and hydrophobicity of the nanochannels – in addition to external parameters such as electric potential, pressure, presence of gases – have a dramatic influence on the probability of opening and closing of the gate. This largely unexplored confined phase transition is known to cause low frequency noise in solid-state nanopores used for DNA sequencing and sensing, limiting their applicability. In biological channels, hydrophobic gating might conspire in determining the high selectivity towards a specific ions or molecules, a characteristic which is sought for in biosensors. The objective of HyGate is to unravel the fundamental mechanisms of hydrophobic gating in model nanopores and biological ion channels and exploit their understanding in order to design biosensors with lower noise and higher selectivity. In order to achieve this ambitious goal, I will deploy the one-of-a-kind simulation and theoretical tools I developed to study vapor nucleation in extreme confinement, which comprises rare-event molecular dynamics and confined nucleation theory. These quantitative tools will be instrumental in designing better biosensors and nanodevices which avoid the formation of nanobubbles or exploit them to achieve exquisite species selectivity. The novel physical insights into the behavior of water in complex nanoconfined environments are expected to inspire radically innovative strategies for nano
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Towards common digital government indicators and support for European cities' in the context of a Horizon 2020 call.

assistant: **Objectives**

Cities are at the forefront of delivering digital government in Europe, but they are not sufficiently involved in the policy debate and do not encounter sufficient support. UserCentriCities is a project driven by six cities and regions to deliver the goals of the Tallinn declaration at local level, supported by Eurocities, the largest association of European cities, VTT, a world-class research centre, and led by the Lisbon Council, a Brussels based think tank which has advised the Estonian presidency on the Tallinn declaration.UserCentriCities aims at delivering a better buy-in of the Tallinn declaration by local authorities, a set of common indicators to benchmark progress, a toolkit and mutual learning activities to share insight, and the involvement of a large number of new cities.The goal is to help cities move towards user centric services by providing data and support. In addition, UserCentriCities aims to stimulate healthy competitions among cities and to involve them on a permanent basis in EU-level technical debates.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Integrating information from molecules to man: knowledge discovery accelerates drug development and personalized treatment in acute stroke'.

assistant: **Concept**

Decades of biomedical research in acute stroke has led to the discovery of genetic, molecular, neuroimaging and epidemiological disease markers that may profoundly improve the treatment of stroke patients - and the targeting and speedy testing of new therapies. The quantity and complexity of these data, however, currently prohibit the integration of this wealth of information into individualized patient management - and cost-effective drug development.I-Know is a knowledge discovery IT-based tool to aid early stroke diagnosis, stroke treatment, drug development and identification of risk factors as targets in disease prevention. In patient management, the I-Know system will use computerized stroke disease progression models (DPMs) (generated in this proposal) to provide an accurate diagnosis in individual patients (based on patient history and genetic profile, biochemical, clinical and neuroimaging findings). Interacting with the physician, I-Know will produce images, predicting the course of the disease given available therepeutic options and their specific actions recorded in other patients (DPMs from clinical trials). This allows physicians to diagnose and treat the patient on the basis of a wealth of information otherwise impossible to integrate by the human mind.In drug development, the pharmaceutical industry will use the I-Know stroke DPMs in classifying data in patients treated with new drug candidates, comparing it with DPMs from untreated patients. The statistical power of I-Know, we claim, far superceeds standard estimators of drug action (neurological outcome, infarct size), allowing demonstration of drug efficacy by a fraction of the patients, resources and time used today. The resulting, drug-specific DPM - accounting in unparalleled detail for drug action
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Relevance of accounting information for corporate debt financing'.

assistant: **Innovation**

From 2005 the EU requires publicly listed companies to prepare financial statements based on IFRS instead of national accounting rules (EC No. 1606/2002). Regulators have suggested that harmonisation of financial reporting should bring benefits to companies and their capital providers which would in turn improve the efficiency of the European financial markets significantly. However, it is possible that these expectations are not borne out. Furthermore, in the aftermath of the recent financial crisis, IFRS regulation experienced significant changes, in particular with respect to fair value accounting. These arguments create a strong rationale for conducting the research outlined in this proposal. The objective of proposed research is to examine the financial statements effects of accounting regulation changes from the debt holders' perspective. While existing research mainly examines the implications of regulation changes for the equity markets, there is little evidence from the debt markets and the project attempts to fill this gap. The research will undertake a comprehensive analysis and develop understanding of the relevance of accounting information for corporate debt financing. It will be investigating how financial reporting as an information device can change the debt market infrastructure. Findings will be valuable in helping policy makers, regulators and practitioners to learn and adapt, and thus support the development of a more efficient EU economy. Since accounting and financial reporting are multi-disciplinary phenomena, accounting regulation is merely one part of a complex equilibrium. As a result, this research proposal will promote empirical financial reporting research by integrating multi-disciplinary theory and empirical methods from accounting and re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Support for Public Procurements to facilitate the collaboration between SMEs and public sector for the development and adoption in renewables in regions'.

assistant: **Objectives**

The general objective of XPRESS is to facilitate the introduction of innovative RES technologies and increase the share of renewable energy in the final energy consumption through the following specific objectives:1.creating a web platform that supports interacting between public procurers, innovative SMEs and end users of green innovations (WP2);2.mapping of the low carbon energy needs of cities and municipalities with the RES technologies developed by innovative SMEs (WP1 and WP2);3.improving the application of GPPs to innovative RES technologies (WP3);4.increasing the awareness of innovative SMEs about RES technologies via GPPs (WP3); 5.develping a new methodology to evaluate RES technologies developed by innovative SMEs across their life cycle in order to estimate the CO2 emissions (WP4).XPRESS will focus initially on selected cities and municipalities within UK, Italy, Norway, Germany, Sweden, Spain, Denmark, Slovakia, Portugal and Belgium with the goal of extending the analysis and the involvement to wider regions within those countries.The project will demonstrate the positive impact of innovative GPPs on cities and municipalities and SMEs in terms of energy savings, energy efficiency and lower carbon emissions.


**Keywords:** Green Public Procurement, Regional policies, Small Medium Enterprises, Life Cycle Assessment (LCA) methodology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ENERGY EFFICIENCY AS A GUIDING PRINCIPLE IN THE BUILDING DESIGN PROCESS' in the context of a Fourth Framework call.

assistant: **Objectives**

To achieve the maximum possible level of energy efficiency in the proposed building.To test and develop design routines and methodologies which secure maximum energy efficiency applicable to commercial building projects in general Innovative aspects:- Develop a method to identify appropriate energy efficient solutions during the design phase.- Follow up and evaluate the measures selected to examine what was gained.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Glycobiology of synaptic pruning in a developing brain' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Effective neuron-microglial communication is a prerequisite to achieve the final connectome. It is mediated by both the formation of new synapses and selective removal of unnecessary connections through synaptic pruning. Recent evidences suggest that superfluous connections are eliminated by microglia. Almost 70% of the connections are lost in a primate cortex within six months of life. But what drives this selective elimination of so many synapses is a million-euro question. Identifying neuronal signals that differentiate weak synapses from the strong ones is an emerging frontier in cellular neuroscience. Several eat-me signals in synaptic pruning have been identified, but spare-me signals that limit phagocytic elimination of synapses are yet to be explored. Sialic acids on neuronal glycocalyx acts as spare-me signal and prevents microglial phagocytosis through Siglec receptors. Aberrant regulation of sialic acid caused neuronal loss and embryonic lethality. It is also becoming evident that sialic acid plays a key role in neurodevelopment, but the cellular and molecular mechanisms by which it regulates neurodevelopment is yet to be explored. This makes sialic acid an ideal candidate to evaluate its role in neurodevelopment. Hence, we aim to interrogate whether sialidases, glycocalyx recognizing proteins are developmentally regulated and also to define sialic acid’s role in synaptic pruning during neurodevelopment. We propose to implement gene, protein expression and metabolic profiling studies to investigate whether sialidases and glycocalyx recognizing proteins are developmentally regulated. Also, we will use fluorescent azido sugars in ex vivo cultures to visualise how sialic acid regulates synaptic pruning during neurodevelopment using superresolution STED microscop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural Studies on the Interaction of Fibronectin and Collagen' (FN-COLLAGEN), addressing dissemination and exploitation.

assistant: **Impact**

Fibronectin (FN) and collagen are two members of the extracellular matrix that play important roles in embryogenesis, cell migration and adhesion, as well as in wound healing. They act together to control fibroblast migration, collagen crosslinking and the removal of damaged tissue. However, despite the apparent biological importance, details on the interaction of FN and collagen remain unclear. Substantial uncertainty exists regarding the number of FN binding sites on different collagen types, the molecular nature of the interaction and the roles of different collagen forms (denatured and native) and fibronectin domains. Importantly, past studies had been unable to reconstitute this interaction using synthetic collagen peptides, precluding possible high-resolution studies. Here, we propose to use biophysical techniques, such as X-ray crystallography, NMR, and fluorescence, to unravel this interaction. Recently, we identified a synthetic peptide derived from the type-I collagen a1 chain that binds the collagen binding domain of FN (GBD), as well as its sub-fragments, with high affinity in solution. Our studies show that this binding is highly specific to the identified sequence. We are currently solving the crystal structure of the 8Fn19Fn1 domain pair in complex with this peptide. Preliminary data suggest that extending this structural work to the remaining GBD subfragments is feasible. This information will allow us to search for further potential interaction sites and validate the hypothesis of multiple binding sites for FN on collagen. We are currently establishing collaborations to explore the implications of the molecular details in model triple-helical systems and in intact native collagen. Our results will provide the basis for further research on the biological