RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Pharmacoepidemiolocal Research on Outcomes of Therapeutics by a European ConsorTium' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Recent pharmacovigilance (PV) issues have led to questions regarding the ability of the current PV system to meet the global needs. Controversies around the assessment of spontaneous reports and conflicting results from pharmacoepidemiology studies may lead to delay in, or inappropriate, regulatory decisions. The PROTECT consortium, consisting of 20 core partners lead by the European Medicines Agency (EMEA), willdevelop and test methods of proactive monitoring of drug safety and benefit risk (B/R) assessment utilising a large range of EU data sources and expertise. in partnership with EFP1A companies, PROTECT will develop essential parameters, methodologies and algorithms to enable data mining, signal detection and evaluation in various types ofdata-sets including spontaneous reporting, registries and electronic health care databases (EHR). impact analysismethods will be used to enhance signal prioritisation.PROTECT will develop means of combining results from clinical trials, spontaneous reporting and observational data, strengthening continuous B/R monitoring in the post-authorisation phase. Bayesian modelling, multi-criteria decision analysis and other analytical methods will be compared. Methods for graphical expression of B/R will betested with different stakeholders.Collection of data directly from patients is underutilized and may be essential when knowledge of total drug consumption or potential confounders is needed or conventional PV is disrupted. PROTECT will trial direct patient data collection in natural language using web-based, telephone and text messaging systems. As well as testingtransferability of the data into a common language, PROTECT will explore linkage to data from EHR and electronic registries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of Suprasensors and Assays for Molecular Diagnostics' (SupraSense) targeting Horizon Europe.

assistant: **Abstract**

SupraSense combines completely new strategies to design and realize biomimetic artificial receptors for bioactive small molecules, i.e. metabolites, with the aim of overcoming long-standing selectivity and sensitivity limitations that hindered other synthetic sensory systems from reaching diagnostic applications. Sophisticated yet easy to fabricate “SupraSensors” will be developed based on unprecedented hybrid zeolitic materials whose binding cavities are modulated by peptide-based cofactors, thereby mimicking enzyme pockets. SupraSensors will be functional and directly applicable for molecular diagnostics in urine, saliva, and blood and will be of utility in point-of-care units and personal homes. Emphasis is given to the detection of metabolites that are important disease indicators.I am an expert on “conventional” synthetic chemosensors and have studied both their merits and fundamental shortcomings. Out of this deep routed analysis, I developed the proposed ambitious strategy that marries principles of molecular recognition with materials science and chemistry-informed deep learning. These SupraSensors will advance the field through the following elements: i) high-energy water release from microporous materials ensures high binding affinity; ii) strategically placed peptide-based recognition elements provide selectivity while offering synthetic tunability; iii) information-rich signal output from SupraSensor libraries enables metabolite distinction in biofluids; iv) novel signal amplification concepts increase sensitivity. SupraSensor discovery will be fast and generalizable to many metabolite classes.SupraSense has the potential to unleash supreme opportunities for multiparameter diagnostics, which will be essential for patient subgrouping based on metabolic phenot
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Quantumbiology: DNA Replication and Bio-molecular Recognition' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

DNA replication is at the core of life and strongly appeals to the imagination. It is also a textbook example of template-directed synthesis, involving enzyme-assisted molecular recognition of incoming bases by the template strand. Yet, in spite of much effort, many fundamental questions about its mechanism are open.In this project, using a quantumchemical approach, we aim at two main objectives:- understanding the electronic nature of molecular recognition in DNA base pairs, in artificial mimics thereof and in larger, macromolecular aggregates of related systems;- unravelling the mechanism of the highly accurate, enzyme-assisted DNA replication and, in particular, understanding the role of hydrogen bonding, steric factors and solvent effects in this multistep process.The two subprojects are intimately connected and reinforce each other. We wish to explore the possibilities of rationally designing monomers whose capability to undergo self-organization can be switched on or off chemically (by a third agent) or physically (by radiation). Potential applications are the controlled and selective formation of macromolecules, nanostructures and materials.Furthermore, a better knowledge and, thus, tuning and control of the DNA replication process is envisaged. On the long term, we hope to contribute to the development in general of quantumchemical approaches to biologically relevant problems, i.e., quantumbiology.Our computations are mostly based on density functional theory (DFT) but also on high-level abinitio theory as well as molecular mechanics (MM). Extensive validation studies, by others and us, have shown that DFT is the method of choice, both in terms of efficiency and accuracy, for large biochemically relevant molecules that involve hydrogen bonding.Our approach furth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Aviation Zero Emissions 2050'.

assistant: **Innovation**

Decarbonisation of Aviation will require strict regulation and monitoring to be aligned with the EU Green Deal in making the EU the world’s first climate neutral region by 2050. EU regulation is continuously evolving, affecting key performance indicators (KPIs) used to measure this ambitious objective. The overall goal of this project is to contribute to the decarbonisation of aviation byassessing airline reduction commitments for achieving net zero carbon by 2050.Applying an interdisciplinary approach, the methodology is divided into three stages: 1) Mapping all the GHG KPIs used by European airlines, to set up targets and follow-up measures; 2) Evaluating the actions taken and planned to reach net zero carbon by European airlines, applying a supervised automatic textual analysis to airline ESG reports - a new source of data not used in the past in the airline industry; and 3) Simulate via traffic scenarios, environmental initiatives and airline commitments to estimate the KPIs feasibility using the System Dynamic (SD) method for the timeframes of 2030, 2040 and 2050.  AZERO’s simulation method is more advanced compared to previous research as it uses real airline emission data and plans they have committed to in the ESG reports. It will allow for the updating of the model on a yearly basis when new editions of ESG reports become available.


**Keywords:** Aviation, emissions, Airlines, EU Green Deal, carbon neutrality targets, sustainability KPIs, CO2, GHG
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Green Bubbles RISE for sustainable diving' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Recreational SCUBA divinga has become a mass leisure activity engaging millions of divers worldwide. The diving industry generates large direct and indirect revenues for coastal communities and Marine Protected Areas (MPAs). Other benefits linked to diving include the promotion of ocean stewardship, contribution to scientific research, fostering social inclusion and personal development. Yet, diving has also negative impacts, due to damage or disturbance of marine habitats and organisms and to conflicts with local communities for the access to/use of the same resources, equity issues, or cultural clashes. These aspects clearly relate to the three pillars of sustainability, covering environmental, economic and social dimensions and can only be addressed by a systemic approach.The central objective of GREEN BUBBLES is to maximise the benefits associated with diving while minimising its negative impacts, thus achieving the environmental, economic and social sustainability of the system. This will be done by: 1) Carefully assessing and modelling the system itself; 2) Developing innovative products based on the issues and needs highlighted by assessment and modelling; 3) Promoting the uptake of such products by the system designing tailored business models and marketing plans. Direct engagement with selected stakeholders (divers, professionalsb, diving operators, certification agencies - CAs, MPAs, NGOs) will ensure relevant feedback throughout the project’s lifetime, as well as effective uptake of results at the end of the project. Cutting across sectors and disciplines, and engaging participants from 3 continents, GREEN BUBBLES will put the European diving system in focus thanks to dedicated R&I with, about and for the European diving industry and will take advantage of pa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integration of herpesvirus into telomeres: From the mechanism of genome integration and mobilization to therapeutic intervention' in the context of a Horizon 2020 call.

assistant: **Objectives**

Herpesviruses cause serious diseases in humans and animals. After initial lytic infection, herpesviruses establish a quiescent (latent) infection, which allows their persistence in the host for life. We and others recently identified a novel mechanism that allows maintenance of the genome of certain herpesviruses during latency, by integrating their complete genetic material into host telomeres. One of these viruses is human herpesvirus 6 (HHV-6) which is associated with seizures, encephalitis, and graft rejection in transplant patients. Sporadic reactivation of the integrated virus ensures continued evolution of the virus as it spreads to a new cadre of susceptible individuals. There are critical gaps in our knowledge regarding the fate of herpesvirus genomes during integration and reactivation as well as of viral and cellular factors involved in these processes.INTEGHER will make use of novel technologies to close these gaps and to devise new therapeutic approaches. Specifically, we will 1) determine the fate of the HHV-6 genome during latency by developing a novel reporter system that allows live-cell imaging of the virus genome in living cells and elucidate epigenetic changes of the HHV-6 genome during integration and reactivation; 2) identify viral and cellular factors that drive virus genome integration and reactivation, using recombinant viruses, drugs and CRISPR/Cas9 genome engineering 3) employ genome-editing tools to eliminate the virus genome integrated in host chromosomes in vitro and in an in vivo model. The proposal utilizes state-of-the-art technologies and pioneers new approaches, particularly with regard to visualization and excision of virus genomes in latently infected cells that are also present in (bone marrow) transplants. Altogether, these studies
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Summer Schools of the European Economic Association' to be submitted under Fifth Framework.

assistant: **Abstract**

The Summer Schools of the EEA are intended for graduate students well underway their Ph.D. and doing their research in a subject very related to the Summer School's topic. During a week they will be brought together around a topic of interest. In the morning, specialists in the field will give series of lectures. In the afternoon the students will present their research work. The possibility of presenting their work, in a friendly and informal atmosphere, to some of the top professors in their area, it is supposed to give them the possibility of improving their own research. Moreover, the Summer School will take the form of a residential seminar enabling intensive scholarly and social contacts among young European economists.The topics selected deal with theoretical and policy issues of a general nature showing, nevertheless, a marked European relevance. These topics are at the same time at the cutting edge of research.The 2002 Summer School's topic is Endogenous Fluctuations". The goal of the Summer School is to provide Ph.D. students with an advanced overview of the more recent developments in the endogenous business cycle literature. This research has shown that business cycles may emerge, even in the absence of exogenous shocks, due to imperfect competition and increasing returns in production. As departures from perfect competition (specially in the labour market) are relevant for European economies, the endogenous fluctuations approach might prove very fruitful for the understanding of European business cycles.The 2003 Summer School's topic is "Microeconometrics". The motivation for this course arises as a result of the increasing use of large individual level data sources in the analysis of economic behaviour and evaluation of economic policy. This not only refle
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Optically tuneable supramolecular field-effect transistors' (OPTSUFET) under Seventh Framework.

assistant: **Objectives**

OPTSUFET aims at enabling cross-disciplinary training and research at the interface between Supramolecular Chemistry, Materials-/Nano-Science, Physics and Electrical Engineering. The overall goal of OPTSUFET is to generate new scientific and technological knowledge by combining supramolecularly engineered nanostructured materials (SENMs), mostly based on organic semiconductors, with tailor-made interfaces incorporating photochemically switchable self-assembled monolayers on substrates and electrodes, for fabricating prototypes of optically tuneable two- (supramolecular wires) and three-terminal devices (field-effect transistors). The training and research objectives of OPTSUFET are: 1. Surface texturing with photoswitchable SAMs: derivatization of electrically conductive/insulating solid substrates and metallic nanostructures with azobenzene SAMs to optically modulate the charge injection at the metal-SENM and dielectric-SENM interface. By controlling the interface chemistry it will allow the tuning of the self-assembly of electroactive molecules at surfaces into pre-programmed supramolecular assemblies. 2. Hierarchical self-organization on textured surface of multifunctional SENMs based on electrically active functionalized carbon-based 1D and 2D nano-objects such as n- and p-type rod-like and discotics (oligo-thiophenes, perylenediimides, hexabenzocoronenes, etc) at surfaces on the functionalized substrates. 3. Nanochemistry and nanoprobes: Scanning probes (AFM, STM, KPFM, C-AFM) quantitative time and space resolved characterization of various physico chemical properties of SENMs, in particular correlation between structural and electronic properties. 4. Fabrication of photoswitchable supramolecular wires and transistors: Measurement of charge mobility, under photoche
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Role of an Integrated Tradable Green Certificate System in a Liberalising Market' (INTRACERT), addressing dissemination and exploitation.

assistant: **Impact**

The main objective of this project is to examine the potential and implications of an international tradable green certificate (TGC) system with respect to EU and national renewable energy policie as well as climate change policies. Particular attention will be paid to:1. The possibilities of integrating TGCs for electricity, heat and gas;2. The linking of TGCs to existing market instruments of the EU and its member states, in particular carbon emission trading (CET);3. Analysing the potential for market distortions and trade-offs and implications for renewable policies if the TGC and CET are not designed appropriately.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Ships oriented Innovative soLutions to rEduce Noise & Vibrations'.

assistant: **Objectives**

Transports are well known to be major contributors to noise pollution. Noise and vibrations (N&V) abatement naturally appears as an important objective for in the greening of surface transports.The SILENV project is a response to this requirement for the maritime domain.The consequences of N&V emissions from the ships are multiple. N&V emissions constitute a disturbance for both passengers and harbour area residents, and in some cases it may be a health issue for crew members. Moreover, the increasing ship traffic-generated underwater noise causes ecological nuisances on marine wildlife. This project proposes a holistic approach to reduce ship-generated Noise & Vibration pollution.After a definition of realistic target levels, existing experimental data from main types of ships and on-site measurements will be analysed to identify the most critical sources of noise and vibration. Innovative solutions will be listed and individually assessed on technical and economical criteria. These solutions shall subsequently be virtually tested and refined on numerical models of entire ships, thus allowing us to scientifically grade N&V improvements.SILENV’ final main deliverable is a “green label” proposal that includes recommended target levels for N&V and associated design guidelines.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Tuning brain fate through modulation of chromatin remodelling'.

assistant: **Objectives**

The mammalian SWI/SNF chromatin remodellers, the BAF complexes, are critical regulators of gene expression by modulating the accessibility of regulatory regions, especially of cell identity genes. Their importance for cellular maintenance and differentiation is emphasised by the fact that they are frequently associated with disease. Mutations in genes encoding BAF subunits are found in over 20% of cancers and are causative for neurodevelopmental disorders (NDD). The prevalence for specific NDD with unique clinical features depends on the mutant subunit. The molecular changes leading to the disease phenotypes are largely unresolved. The functions of BAF complexes and specific subunits during human brain development are also still unclear. SWItchFate thus aims to systematically identify the role of individual BAF subunits and their mutations in brain development and abnormalities. To this end, isogenic wild type, mutant and engineered human induced pluripotent stem cell (hiPSC)-derived cerebral organoids will be used in combination with various bulk and single-cell epigenomics and proteomics tools. SWItchFate will investigate gene regulatory mechanisms altered during brain development with CRISPR/Cas-based loss-of-function screens for all BAF subunits. Using protein degradation tools targeting specific BAF subunits, SWItchFate will pinpoint vulnerable processes and adaptation mechanisms. In addition, cell type- and BAF subtype-specific composition, interaction partners and target sites along brain development will be mapped to decipher BAF-dependent gene regulatory networks. Finally, the molecular changes in BAF mutation-induced NDD that cause the phenotypic changes in patients will be examined and conserved mechanisms across different genotypes will be deciphered using p