RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Design of highly conductive solid thin film electrolyte for stack integration within optical and energy storage applications' in the context of a Sixth Framework call.

assistant: **Objectives**

In recent years, thin film science has grown world-wide into a major research area, and has shown that bulk material properties are indeed very different from their behaviour when considered as a surface. Promising areas for thin film manufactured material s are micro batteries (electrochemical energy storage), micro-supercapacitors (energy impulsion) and electrochromic devices (ie. smart windows). Here, the challenge today lie in the development of solid electrolytes (glasses and crystallized materials) and thin film technology would provide new physical properties (very high ionic and electronic conductivity) and increased chemical and mechanical stability etc. Thin film solid electrolytes require rather specific properties that sometimes are difficult to o btain at the same time, therefore the main S&T objective of the HICONDELEC project is to develop fundamental knowledge in order to enable an optimum design of the solid lithium conducting glass electrolytes with predefined physical and chemical charact eristics. A multidisciplinary RTD approach combining simulation, theory, experiment, validation and use has been chosen, in order to maximise the fundamental understanding of: - Ionic and electronic conductivity phenomena - Thermo-electro-mechanical behavi our The HICONDELEC consortium includes Chalmers, TU Ilmenau, NHRF, WWU, HUT, IST and ENSCPB high level research centres with complementary expertise in the fields of modelling and experimental characterisation of ionic and electronic conductivity and therm o- electro-mechanical behaviour of glass like materials (bulk or thin film). And, in order to validate the generated knowledge for certain applications, technology providers has been added for scaling up and property validation purposes: CTI (PVD target ma nufact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Metabolic Fingerprinting of Autism Spectrum Disorders in Breath by Mass Spectrometry' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Current diagnosis of individuals suffering from disorders on the autism spectrum is based on behavioural and developmental observations, usually in their early life. Even so, there is a significant amount of people having to live with these life-long disorders that remain undetected and no treatment is provided to them. However, it is already established that such disorders are associated with metabolic changes. There is now a growing amount of evidence suggesting that such metabolicalterations can be detected in samples such as blood or urine taken from children early in their life. These routines however can cause significant discomfort to the child.The primary aim of the proposal will involve the use of less invasive sampling techniques such as exhaled breath and exhaled breath condensate for the early diagnosis of metabolic hallmarks of autism spectrum disorders. These samples will be analysed using already established chemical analysis techniques for the detection of small metabolic changes in the obtained samples. Tandem mass spectrometry techniques will be used for the unambiguous identification of these metabolites. Data analysis tools such as principal component analysis (PCA) and hierarchical clustering will be used, to associate these metabolic changes with existing medical records obtained from the patients, to establish a potential diagnostic tool.The potential for the rapid detection of these metabolites will be examined through the integration of novel ambient mass spectrometric ionisation methods such as plasma ionisation. The ability to selectively ionise specific metabolites associated with autism will be investigated with the aim of generating an early prototype of a rapid screening method for routine use. Data generated during the initial stage of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Highly parallel cell culture in nanodrops, a new format for high content cell based toxicity screening on cell on chips' (TOXDROP), addressing dissemination and exploitation.

assistant: **Impact**

Implementing highly parallel cell based assays able to replace animal testing is crucial for a large variety of industries. Some cell-based assays have already been achieved using multi-wells plastic plates where individual cell cultures and their stimulations are realised in wells. Unfortunately these novel technologies did not allow to get the level of discoveries that was expected when phenotyping cells for drug discovery and toxicology. DNA chips experiments have already permit massive analyses of animal and human genomes particularly used for in vitro toxicological studies. More information could be obtained replacing the DNA spots by drops of cell culture allowing to establish the relationship between cell phenotypes and chemical toxicity. The aim of this two year ToxDrop project is to develop a Cell on Chip technology where various phenotypes illustrating cytotoxicity can be characterised through the phenotyping of cells in highly parallel cell based reactions on a single chip. The substrate of the biochip will allow to achieve the necessary precision in the formation of the cellular nanodrops and the high content analyses of cell cultures based on fluorescent, high contrast optical based detection as well as mass spectrometry phenotypic signatures. The project will help three European SMEs to get access to the pioneer technology of the Cell on Chip which could be used in particular for cell based in vitro toxicological studies by the industry. The ToxDrop validation will be planned through discussions with ECVAM and realised through tests in cellular nanodrops by academic laboratories specialised in pharmacological and chemical toxicological studies. In order to reproduce on the Cell on Chip several assays previously tested in animals, toxicity will be carried o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'A lithospheric study in the North sea from the analysis,processing and interpretation of deep seismic reflection and refraction data' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content The main target of this project is the image of the structure and reflectivity characteristics of the crust and lithospheric mantle beneath the Southeastern region of the North Sea based on seismic profiles. Careful processing of the data and interpretation can lead to a very good image of the zones of the crust unavailable by geological direct methods. This study will concentrate on aspects such as possible reactivation of collisional faults, the role of the Caledonian suture and identification of Paleozoic sediments below the graben- a possible evidence for a paleozoic rift phase!!-. The acquisition of data is completed.. They have a great potential as the quality of the data is good and is expected with some reprocessing to have better images. In addition, the experiment design will permit a full integration of coincident reflection and refraction data so the crustal characteristics can be compared in both methods to provide a better view and understanding of the lithospheric processes. Training content (objective, benefit and expected impact) With this project, the applicant will benefit from the use of the most modern software and technology to proccess and interpret seismic data. Become more familiar with the handling and modeling of seismic data is one of my personal interests in this proposal. Also, the final interpretation, provided the quality of the images has been enhanced, will give new ideas for a better understanding of the processes involved in the formation of the North Sea Graben in particular, but for any other similar geological setting in the world. The 'applied' dimension of the study comes from the application of the seismic tecnology to obtain high quality images of the subsoil and geometry of the crust, highly enc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Compressed Sensing Techniques for Wireless Sensor Networks' (2014-2020) under Horizon 2020.

assistant: **Objectives**

The emerging Compressed Sensing theory provides an entirely new perspective on the basic principles governing data acquisition, compression, and reconstruction. The main goal of this project is to understand the fundamental design principles and investigate the ultimate capabilities of Compressed Sensing techniques in wireless sensor networks. What distinguishes this project from prior related work is that it addresses large sensor networks that rely only on wireless interconnections and are subjected to arbitrary temporal and spatial variability (caused, e.g., by channel fading, addition/removal of nodes, node mobility, etc.). We propose an optimization-based methodology which integrates compressed sensing and wireless data transport into a unified optimization framework which will serve as the mathematical basis for a systematic design and, ultimately, will reveal the performance limits. This work will provide: 1) mathematical characterizations of the optimal tradeoffs between different fundamental performance criteria (e.g., energy versus sensing accuracy), and 2) practical algorithms and hierarchically structured network protocols (i.e., key enablers for Internet of Things (IoT) applications) able of handling large amount of data with lower energy and bandwidth consumption than in existing systems. The ultimate goal is to develop the foundations for a general theory of compressive sensing in wireless sensor networks which includes all aspects mentioned above. Such theory will have a breakthrough-making impact both through direct application on the wireless sensor networks, and in the science of network and data processing in other fields, including economics, transportation, biology, etc. From a career development perspective, the main goal is to strengthen the rese
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'iSAFE Internet Safety Awareness for European primary school children' (2014-2020).

assistant: **Innovation**

More and more children are using the internet at a younger age. The EU Better Internet for Children Strategy recognises the significant risks online to our children. The EU recognises the need for an effective education programme to highlight online risks to children and to equip children with the tools to deal with these risks effectively.However, no effective solution to this problem has been developed and according to the EU, 4 in 10 children in Europe have encountered online risk, for example cyberbullying and being exposed to user generated content promoting anorexia, self-harm, drug-taking or suicide. These risks have a significant impact on our children.The iSAFE (Internet Safety Awareness For Europe) Project will form a European co-operative to keep children safe online. iSAFEs innovative education platform will disrupt how children are educated in schools. iSAFE enables children to teach each other internet safety in a 3D world they are familiar with. Children are empowered HOW to think, as opposed to WHAT to think equipping them with the critical thinking skills necessary to protect themselves in this rapidly changing online environment.In 2021, iSAFE will have the potential to reach at least 1.54m primary school pupils per year in the EU28 states, with a profit of €1.8m, employing 44 people, with a ROI of 143%.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Innovative designs, extrapolation, simulation methods and evidence-tools for rare diseases addressing regulatory needs'.

assistant: **Concept**

The evaluation of new medicines for rare diseases (RD) including rare paediatric RDs is challenging for several reasons, among which are the small patient sample sizes, heterogeneity of patients and diseases and heterogeneity in disease knowledge. Due to these difficulties, access to effective treatments and the number of treatment options are often limited in RDs. INVENTS aims to provide clinical trial trialists, researchers and regulators with a global framework encompassing methods, workflows and evidence assessment tools to be implemented in orphan and paediatric drug development. Our ambition is to significantly improve the evaluation of evidence and regulatory decision-making through the development and validation of: refined longitudinal model-based diseases trajectories and treatment effect, improved extrapolation models, in silico trials (e.g., virtual patient cohorts), optimised model-based clinical trial designs and evidence synthesis methods. These will be evaluated through simulation studies and tested on extensive data from a range of use cases provided by our industrial partners Roche and Novartis and Real World data (RWD) from RD registry. The INVENTS framework will improve consistency and efficiency of the drug evaluation process for RD by augmenting clinical evidence without compromising its scientific integrity and providing regulators assessment credibility criteria. At the end of this 5 years project, the European industry will be able to exploit novel and improved clinical trial designs, in silico trials and RWD analysis approaches supporting drug development in RD. The European Medicine Agency and European national regulators (including Health Technology Assessment bodies) will be supplied with a general framework allowing better informed decision
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PROmotion and coordination of environmental research in Central and Eastern Europe for a sustainable Development with the support of the Enterprise Europe Network' (PROCEED) targeting Seventh Framework.

assistant: **Abstract**

PROCEED focuses on the communication and dissemination of environmental research results and practices originating in Central and Eastern European Countries (CEEC) towards industry, policy makers and public and private research centres (including Academia),with the aim to enhance the uptake of research results and foster the participation of CEEC in EU-funded research projects through S&T cooperation with other European partners.The specific research sectors on which PROCEED will focus are Air pollution,Chemical pollution, Environmental Technologies.The partners will create a data base of all innovative environmental research practices and results originating in CEEC and will lead a SWOT analysis of the existing channels and tools used to communicate environmental research results in Europe with specific focus to Academia, policy makers and industry.The PROCEED communication system will be made of personal communication in national and international workshops and a web 2.0-based research social network, an interactive communication channel specifically targeted at creating research opportunitiesAmong other, results will be the signing of TT agreements and the collaborative participation in FP environment project proposalsThe project partnership covers 9 CEEC (6 new Member States and 3 Associated countries) and 3 EU-15 Member statesAll 12 project countries are represented by at least one partner member of the Enterprise Europe Network which will be the main communication channel in the project, with its 600 members present in all European countries and beyond (including China and United States) and an extended network of contacts and partners.Partners will engage other EEN members, the Fp7 National Contact Points Network and other relevant FP7 coordination and support ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding and manipulating Antibody Dependent Cell Cytotoxicity (ADCC) by human Natural Killer (NK) cells' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

High-resolution microscope images of immune cells contacting other cells have revealed temporary membrane structures, often called immune synapses (IS). Proteins commonly segregate into specific regions at the contacts between cells, and exploring how such changing arrangements of proteins occur and how they control immune cell communication is the new science opened up by the immune synapse concept. Over the last decade the use of monoclonal antibodies has revolutionised the treatment of severe human diseases, such as non hodgkins lymphoma (NHL) and rheumatoid arthritis (RA). One way that these antibodies work is by triggering Natural Killer cells to directly kill diseased target cells. Typically antibodies have been used to either block ligand receptor interactions or to evoke antibody effector function and kill malignant target cells by antibody-dependent cell cytotoxicity (ADCC). Crucially, nobody has yet determined what happens at IS when antibodies trigger killing of diseased cells. Through this project we will focus our research to improve our basic understanding of the molecular dynamics that occur during ADCC and to investigate antibodies specifically engineered to enhance ADCC. Here, we plan to use state-of-the-art technologies to image IS during antibody-mediated killing with a view to learning how to best optimize antibodies for this function. Specifically, the spatial relationship and segregation of proteins at the submicrometer scale will be determined during ADCC and compared for the different antibodies and model systems developed. This will establish what determines the efficiency of ADCC and will facilitate the rational design of modified antibodies for optimal medical use. This project will benefit from the knowledge and experience in imaging and cell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ARGOS (“Acoustic Reporter Gene Overhaul in Saccharomyces”)' (ARGOS).

assistant: **Concept**

As acoustic reporter genes (ARGs), gas vesicles (GVs) have recently seen a rapid rise in biomedical interest with applications including non-invasive diagnostics and treatment. Gas filled protein nanostructures, GVs are unique, genetically encodable microbubbles that provide a stable ultrasound contrast handle. Due to their complex assembly inside of cells, the use of GVs is currently constricted to a number of wild-type, minimally engineered gene clusters and the range of cells they can be deployed to is limited. By contrast, fluorescent proteins (FPs) as optical reporter genes can readily be deployed to any biological context and decades of protein engineering have imbued them with an expansive array of colors, improved brightness, and sophisticated applications.In this action, we aim to parallel the immense development achieved for FPs and overcome the limitations of re-engineering gas vesicles by linking their successful assembly in yeast cells to a clear optical readout, unlocking high throughput screening by FACS. Utilizing this platform, we will screen libraries of modularly assembled GV gene clusters for successful expression in S. cerevisiae. The Sc2.0 synthetic yeast genome platform will then enable the evolution of yeast genomes for superior GV assembly pathways using SCRaMbLE. Our novel GV gene clusters will be targeted for carefully guided directed (co-)evolution of one or multiple GV genes to develop synthetic GVs that provide improved contrast and phenotypes to expand their applications. To facilitate the swift engineering of ARGs for novel applications, we will obtain next-generation sequencing and single-cell RNA sequencing data of our GV genes and evolved yeast genomes to develop a deeper sequence to function understanding of GV expression in eukaryote