RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'creTRAP for in situ Characterization of Fibrosis-Promoting Pathways in  Non-alcoholic Fatty Liver Disease', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The aim of the proposed project is to develop and employ novel tools to identify and target fibrosis-promoting, molecular pathways in non-alcoholic fatty liver disease. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Affecting 20-30% of the Western population, NAFLD is now the most common liver disease. Yet, the lack of tools for studying the initiation and progression of NAFLD at the cellular level limits our ability to develop novel strategies for rational, therapeutic intervention. This proposal details a cross-disciplinary research project aimed at addressing this challenge while facilitating the transfer of knowledge and new technologies to the Danish biomedical research community. Over the course of the proposed project, the aim will be pursued through fulfilment of these specific objectives: (A) Development of novel biochemical tools for in situ gene expression profiling and gene knock-down in select cell types. (B) Implementation of these tools to discover intra- and intercellular mechanisms linking metabolic stress to chronic liver disease in mouse models of diet-induced fibrosis. (C) Cross-disciplinary, experimental validation of hypotheses generated from bioinformatic integration of gene expression profiles from individual cell populations and experimental treatment of NAFLD in animal models. (D) Communication of discoveries and their relevance through external seminars and through scientific, popular, and social media platforms. Through research and training activities at the University of Southern Denmark, development of collaborations with researchers at partnering institutions, and dissemination of results to the broader European community, the proposed project serves as foundation for my independent caree
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'interconnecting Knowledge for the  early identification of issues, events and developments  (e.g. wild cards and associated weak signals)  shaping and shaking the future of STI in the ERA' in the context of a Seventh Framework call.

assistant: **Objectives**

In recent years, Foresight has emerged as a key instrument for the development and implementation of research and innovation policies with long-term perspectives. Much futures work and Foresight exercises are little more than extrapolations. Some activities show an interesting mix of approaches combining three types of elements: prospective studies of long-term opportunities and alternatives, participatory networking, and policy orientation. However, far too little attention has been paid to the identification and analysis of wild cards and weak signals (WI-WE). But two things are widely agreed upon in discussions of high-impact but low-probability events.  First, it is vital to examine such events. Some of them are almost bound to happen, even if we cannot say what these are. Many organisational crises relate to failure to spot surprising developments sufficiently far in advance.  The weak signals that might warn of an impending wild card have been ignored. Second, our methods for identifying and detecting WI-WE are woefully underdeveloped. The reason that most futurists use examples of wild cards to wake up their audiences, but do not then follow through on this, is that there is relatively little that is formalised and reproducible in WI-WE analysis. The proposed study will provide answers to these questions, by mounting a sustained and multi-method effort to explore approaches to conceptualisation of WI-WE that can inform practice; establish tools for WI-WE analysis; and to additionally validate these in a specific application areas.  The application area in question is the European Research Area. Wild cards and weak signals relevant to the future of the ERA will be the substantive focus of the study: so we will talk about conceptual and methodological contributions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Civil uav application and economic effectiveness of potential configuration solutions' under Fifth Framework.

assistant: **Concept**

CAPECON aims to advance the utilisation of safe and low cost Unmanned Air Vehicles (UAVs) in the civilian commercial sphere. CAPECON will survey in-depth applications of potential users, and will produce reliable safety and cost assessments. It will compare different aerodynamic configurations and define possible civil UAV configuration ready for engineering development. CAPECON is a research synthesis of critical technologies, configuration design, simulation and cost appraisal methods, aimed at the design and production of safe and commercially viable, civilian UAVs. The project will concentrate on configurations and technologies suited to High and Medium Altitude Long Endurance (HALE and MALE) missions and also to Rotary UAVs. Currently the commercial potential for the civilian use of UAVs is largely untapped; hence CAPECON will enable the EU to gain a leading role in this emerging technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A new paradigm in agrochemistry by manipulating structural bulk' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The advent of agriculture has played a decisive role in humankind’s ability to create localized settlements, which has consequently led to the development of complex societies.With increases in human population, the need for reliable large-scale agriculture grew. Sustenance of modern society is a significant societal challenge and relies heavily on two factors: fertilization and crop protection. While the Haber-Bosch process, and related concepts, have contributed to solving the former, crop protection remains a key issue. Significant innovation in many key areas is necessary to enhance the effectiveness of crop protection, as the invention of economically viable processes for the creation of novel types of crop protection agents will play a decisive role in enabling agriculture to sustain the world’s population.In a project supported by the ERC CoG VINCAT, Nuno Maulide and his group (at the Institute of Organic Chemistry, University of Vienna, Austria) have made groundbreaking discoveries that could significantly impact the production of agriculturally relevant compounds. The goal of the ERC PoC project AGROSTERICS is to implement this technology to ultimately demonstrate its efficacy and to develop an appropriate market analysis and IP strategy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'From science to products' under Fourth Framework.

assistant: **Concept**

This proposal plans to develop a comprehensive report, following the example of the Green Paper on Innovation, taking into accunt the idiosyncratic characteristics of the European chemical industry. The project has three main objectives: a) Analyse the science and technology base and the dynamic performance of the European system of innovation" in the chemical industrym with particular attention to its contribution to economic growth through innovation and competitiveness, and to the ability to translate its research into commercially useful products. b) Analyse the forces that encourage the diffusion of chemical innovations on downstream user industries, across regions, and on SMEs, with particular attention to the diffusion processes (user-producer interactions and spillovers to other industries, regions and SMEs. c) Discuss policy implications and actions, which will be based on a comprehensive study of the factors and the conditions enlisted in the previous two points. We plan to hold four workshops to discuss work in progress and diffuse preliminary and final results, with the participation of external discussants and other interested parties (particularly industry officials and European policy makers). We also plan to produce a Final Report whose style, structure, and content will resemble the Green Paper, a set o Special Reports which will discuss more specific topics in greater detail, and a series of working papers with preliminary or final results of the study."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Small non-coding RNAs in cell function and disease' to be submitted under Seventh Framework.

assistant: **Abstract**

Small non-coding RNAs including microRNAs (miRNAs), short interfering RNAs (siRNAs) or Piwi interacting RNAs (piRNAs) have been discovered recently and extensive research revealed that such RNAs function as key-regulators of gene expression. Small non-coding RNAs cooperate with members of the Argonaute (Ago) protein family to regulate gene expression at the level of transcription, mRNA stability or translation. While small RNAs serve as sequence-specific guides, Ago proteins constitute the mediators of gene silencing processes. In order to identify functional classes of small non-coding RNAs, it is important to analyze interactions with members of the Ago protein family. We propose to isolate and clone Ago-associated small RNAs. Processing products of small nucleolar RNAs (snoRNAs) can give rise to functional small RNAs and it is very likely that other non-coding RNAs including tRNAs or rRNAs produce functional small RNAs with so far unrecognized cellular functions. In the second part of the proposal we plan to investigate the role of miRNAs in disease. In the cancer field, the cancer stem cell hypothesis suggests the existence of tumor stem cells that are important for tumor maintenance. Such stem cells are difficult to target and might be the cause of tumor re-appearance after therapy. Since glioblastoma is a fatal tumor and tumor stem cells can be isolated we will analyze miRNA expression in glioblastoma stem cells. Indeed, a first cloning approach identified several tumor stem cell specific miRNAs. In the proposed project we plan to analyze the biological function of such glioblastoma stem cell-specific miRNAs. We hope that our work not only contributes to a better understanding of the cancer stem cell hypothesis but will also depict new ways for cancer therapy.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Study of extremely diluted microemulsions' under Fourth Framework.

assistant: **Concept**

Research objectives and content Lately a dilute bicontinuous cubic phase has been discovered in a Iyotropic system consisting of surfactant, water and oil (1). Being strongly correlated, this phase shows characteristic lengths up to 2800 A. Surprisingly, the structure exists upon dilution of a microemulsion, i.e. Iiquid phase. Moreover, the liquid to solid transition seems to be continuous or only weakly discontinuous. The stability of this phase cannot be explained by the existing description of diluted phases such as lamellar or sponge phases. The project is to improve the structural characterization of this phase and to study its dynamic properties. This will enable us to give a good description of its stability. Experimental techniques will be scattering methods (X-ray, neutrons, light), rheological measurements and frequency dependent conductivity measurements. Training content (objective, benefit and expected impact) The knowledge of the applicant concerning both the experimental techniques described and the physical-chemistry of complex fluids will greatly improve. This will prepare her for either an academic career or a position in industry. Links with industry / industrial relevance (22) The slow release of drugs is one of the current applications of cubic phases, and the structural dimension of extremely dilute cubic phases make them an interesting candidate for similar projects. However, the fundamental aspect is too recent to foresee all possible future applications. (I) U. Peter, S. Konig, D. Roux, A.-M. Bellocq, Phys. Rev. Lett. 76, (1996) 3866 U. Peter, Diplomarbeit, Technische Universitat Munchen (1995)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Reduction of air emissions at kraft pulp mills'.

assistant: **Objectives**

The ultimate objective is to develop technically feasible methods for the control of air emissions, particularly nitrogen oxide emissions, at kraft pulp mills. This will be achieved by detailed investigations on the formation, distribution, and behaviour of different nitrogen compounds during the main sub-processes of kraft pulping and recovery of pulping chemicals. It will then be investigated how the distribution and behaviour of the nitrogen compounds can be affected by modifying conditions during cooking, black liquor evaporation and combustion, smelt dissolving, and white liquor preparation. Only with all that type of information it will be possible1) to create overall millwide nitrogen balances;2) to evaluate the role of each sub-process as a source of nitrogen chemicals;3) to evaluate the potential of each sub-process modification as a means to control the emissions; and4) to compare different emission control methods and strategies.As a result of the project, there is a deeper understanding on the formation and handling of the NOx and other nitrogenous emissions at kraft pulp mills. Especially important is that there is also now a deeper understanding on the entire pathways of wood nitrogen (proteins) from chips to the emission compounds (NOx and ammonia) in each sub-process of the fibreline and recovery systems.In more detail, the results show that:1. The nitrogen content of the wood raw material is typically 0.05-0.15% (by weight).2. A substantial part of the nitrogen is dissolved from the wood chips into the cooking liquor at early pulping stages; there are no raw material-specific differences. The pulps going to bleaching contain only traces of nitrogen.3. The cooking conditions have only marginal effects on the release of nitrogen from chips.4. Approximatel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Gamma Ray Bursts and Their Afterglows' (GRBANDAFTERGLOW).

assistant: **Concept**

More than thirty years have passed since the detection of Gamma-Ray Bursts (GRBs) was first reported and enormous observational and theoretical efforts have been devoted to understanding this enigmatic phenomenon. Today, the GRB enigma, once one of the greatest mysteries in astrophysics, is partially solved: GRBs are the death throes of massive stars and the birth cries of black holes. Yet these objects continue to fascinate astronomers and the general public due to their unparalleled brilliance, the amazing relativistic bulk Lorentz factors involved, and because the conditions that lead to a GRB are still mysterious. What makes a massive star produce a GRB rather than a supernova?  In this focused proposal, we concentrate on issues related to the geometry of the ejecta as a jet. We propose to construct, for the first time, relativistic two-dimensional self-similar hydrodynamic solutions. We will utilize these solutions to better understand relativistic jets, their lateral spreading and their interaction with the surrounding medium. Our research will illuminate the energetic content of the events, explore their geometrical diversity, and more accurately determine how frequent they are in the universe. We will explore an innovative way to identify orphan afterglows using the upcoming satellite GLAST.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'innoVative bIo-based chains for CO2 VALorisation as aDded-value organIc acids' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The valorisation of industrial CO2 emissions is a cornerstone in EU strategies for climate change and circular economy. Bio-based Industries (BIs) are perfect candidates to apply this CO2 valorisation, since they could to turn their biorefineries’ emissions into feedstock and close the carbon loop. Nevertheless, there is still a strong need of reliable and cost-efficient CO2 conversion technologies to make it possible.  VIVALDI proposes an integrated solution allowing the conversion of biogenic CO2 into added-value organic acids, powered by ground-breaking advances in CO2 purification, electrochemical catalysis, microbiology, synthetic biology, and bioprocess engineering. The solution comprises 4 main steps:  1. CO2 purification/enrichment from industrial streams and electrochemical reduction to formic acid (FA) and methanol (MeOH) using electrochemical reactors and gas diffusion electrodes. 2. Nutrient recovery (NH4+, Ca2+, Mg2+, K+) from industrial wastewaters using bioelectrochemical systems. 3. Bioproduction of target organic acids using a microbial platform based on specific engineered yeast strains (P. Pastoris), using as feedstock MeOH/FA/CO2 from step 1 and nutrients from step 2.  4. Industrial validation of the bioproduced organic acids (i.e. efficient downstream processing and on-site industrial validation).  VIVALDI will use real gas emissions from 4 key BIs and will focus on the bioproduction of 4 industrially relevant organic acids with different applications and market penetration (LA,SA,IA,3-HP). These acids can re-enter the production process flowchart of biorefineries, thus enhancing the sustainability of their current products or even opening new business possibilities. Moreover, VIVALDI’s feasibility will be confirmed also through an integral sustaina
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Design, Simulation and Flight Reynolds Number Testing for Advanced High-Lift Solutions'.

assistant: **Objectives**

DeSiReH focus on both, the numerical design tools and the experimental measurement techniques for cryogenic conditions, with the objective to improve the industrial design process for laminar wings in terms of product quality, efficiency, and development cost reduction. The work focuses on the design of high lift devices. DeSiReH addresses the following quantified objectives which will make a significant contribution to meeting Vision 2020 goals:  1) Reduction of industrial A/C development costs by 5% by reduced and more efficient Wind Tunnel Testing 2) Decrease time-to-market by 5% by improved aerodynamic design turn-around time 3) Improve industrial High-Lift design process efficiency by 15% 4) Reduce A/C drag by 5% by enabling NLF though compatible High-Lift-Design  To accomplish these objectives the project is planned for a period of 4 years and a budget of 7.6 Mio. Euro. The consortium consists of 6 industry partner, 7 research establishments, 3 universities, 2 small and medium-sized enterprise and the European Transonic Wind tunnel (ETW).   Existing and validated high-fidelity numerical tools are composed to an efficient High-Lift design and optimization process chain in WP1. The strategies and tools developed are applied in WP 2 to the aerodynamic design of a high lift system for the future pointing HARLS wing (High Aspect Ratio Low Sweep) with the constraint to maintain Natural Lamiar Flow at cruise to the best possible extend. WP 3 focuses on the improvement of the experimental measurement technique for cryogenic testing. The objectives here are to enhance the measurement accuracy of the results and to generate the capability to apply different important techniques (e.g. transition measurement & deformation measurement). These techniques are finally applied in