RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Targeting Hernia Operation Using Sustainable Resources and Green Nanotechnologies. An Integrated Pan-European Approach' to be submitted under Seventh Framework.

assistant: **Abstract**

Hernia operations are among the most common surgical procedures performed today with over 20 million cases annually worldwide. Hernia incidents are associated with pain and poor quality-of-life for the patient and lead to enormous healthcare costs, exceeding US $48 billion in the US annually. At present, hernia operations rely heavily on non-degradable polypropylene, polytetrafluoroethylene and nylon meshes. However, these polymers are often associated with foreign body reaction; implant failure; and hernia reoccurrence (over 42%). Moreover, leaking chemicals of these polymers are often deleterious to the surrounding cells and tissue and immobilise post-operative drug treatments. In addition, the process technologies are often associated with environmental risks. Herein, we propose a novel approach that employs recent advances in green nanotechnology and sustainable raw materials for scaffold fabrication that not only will eliminate toxic chemicals from the processes, but will also enhance functional repair due to superior biological properties. Specifically, we aim to fabricate a nano-fibrous mesh with well-defined nano-topography using cellulose; human recombinant collagen, derived from transgenic tobacco plants; and biodegradable polylactic/polyglycolic acid as raw materials. The green credentials of this innovative approach lie in the use of sustainable eco-friendly raw materials that will produce biodegradable waste products and therefore replacing hazardous chemicals currently in use. Thus, this proposal directly fits the call for the substitution of materials or components with ‘green nano-technology’.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elucidating the ORIGINS of Solar System(s): Anatomy of primitive meteorites' (ORIGINS).

assistant: **Innovation**

This proposal seeks to better understand the origins of our planetary system, and of exo-planetary systems beyond. Carbonaceous chondrites (CC) and samples from the recently returned Stardust mission are amongst the most primitive materials available to us. The components that constitute these rocks formed in the early solar system, and are the likely building blocks of planets. We will perform orbital studies of CC to identify their source regions within the Solar System, providing us with a spatial context to interpret their composition. We will define the chemistry, mineralogy, geochemistry and isotopic composition of these building blocks. Coupled with experimental work, these studies will clarify the relationship of CC and Stardust constituents to each other, their formation mechanisms, and define the physical and chemical conditions in the pre-terrestrial environment, and the astrophysical environment of the early sun. The picture of our Solar System that will emerge from our study will be used as a touchstone to better understand the formation of the Earth, as well as dusty disks around other stars and the probable abundance and composition of newly discovered exo-planets. These objectives can be achieved thanks to the multidisciplinary team we brought together, to the quality of our instrumentation, and to our ability to tackle both theoretical and analytical problems. The proposed collaboration will generate a European network of young researchers in the field of space and solar system sciences. They will form the core of a technically competent, multi-skilled generation of cosmo-chemists, cosmic-mineralogists and astrophysicists able to significantly support/contribute to a Golden Era of European Space Exploration", in which ESA and other organisations are alr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Astrocyte-neuron COmmunication in METabolism and obesity.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Obesity and type 2 diabetes have been increasing during the last decades, becoming highly prevalent diseases in our society. Until very recently, astrocytes and other glial cells have been traditionally known as supportive cells to neurons, but the host research group led by Prof. Matthias Tschöp has recently reported that insulin receptors (IRs) in astrocytes regulate glucose delivery into the brain and lack thereof leads to a reduced response of glucose-induced suppression of food intake (Garcia-Caceres et al., Cell 2016). These data, together with previous findings, suggest a new paradigm in which astrocytes interplay with neurons in the CNS control of metabolism, body weight, and energy balance. However, the molecular underpinnings remain to be investigated. My main objective is to test the hypothesis that astrocyte-neuron communication is required for maintaining a normal energy homeostasis, and its impairment contributes to the pathogenesis of obesity. To achieve this, I will use Designer Receptors Exclusively Activated by Designer Drugs (DREADD) technology to examine whether astrocyte activity is required for maintaining a normal energy homeostasis. I will generate two transgenic mouse models (dnSNARE mouse and iBot mouse) to specifically interfere with the release of gliotransmitters in order to test whether astrocytes release vesicles to regulate the activity of hypothalamic neurons in the control of energy metabolism. Finally, I will investigate whether hypercaloric diet disrupts astrocyte-neuron communication, thus contributing to obesity progression. This project has the potential to reveal new mechanism(s) of metabolic homeostasis and how its impairment explains the development of obesity. Moreover, this proposal will enhance my individual competence in ter
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections' to be submitted under Horizon 2020.

assistant: **Abstract**

Light4lungs addresses the problem of antimicrobial resistance in the treatment of chronic lung infections, which are the leading cause of morbidity and mortality in patients with diseases such as cystic fibrosis and hospital-acquired lung infections. The goal is to develop a novel therapeutic scheme for the treatment of the infections, whereby antibiotics will be replaced by inhalable light sources that will excite bacterial endogenous photosensitisers (e.g., iron-free porphyrins), eliminating the pathogenic bacteria by the photodynamic effect (local production of cytotoxic reactive oxygen species by the combined action of light, a photosensitiser and oxygen) irrespective of its multidrug resistance profile. The treatment will be safe for the host tissue because of its lack of self-photosensitising ability. Light4Lungs departs from current paradigms: (1) bacterial infections will be treated without antibiotics, which will be replaced by breathable light sources; (2) bacteria will be eliminated without any externally-added drug, taking advantage of endogenous photosensitisers; (3) a breathable light source will be used to elicit the therapeutic action, avoiding the use of invasive physical tethers to deliver light to the lungs. The project encompasses the development of particles with persistent luminescence, the aerosol technology for activation and delivery to the lungs, and the definition of the treatment parameters through toxicity and efficacy tests in clinically relevant models of respiratory infections. The project combines several different scientific expertise from photonics to medicine. The results will be useful for patients with recalcitrant respiratory tract bacterial infections and will eventually be extended to other diseases in the lungs and in other inte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Molecular control of brain regionalization and neural cell diferentaition by planar inductions' (ISOPLANAR) targeting Sixth Framework.

assistant: **Abstract**

This proposal deals with the role of Fgf8 in regulating regionalisation of the vertebrate brain during embryogenesis and its potential role as a regulator of function in the mature brain. In embryos Fgf8 is a primary signal involved in brain regionalisation and pattern formation. Localised Fgf8 expression in co-operation with Wnt, Bmp and Shh signals promotes localised cell fate determination and long range patterning of surrounding areas. We propose to study the role of FGF8 dependent Ca2+ signalling in this long range integrated signalling phenomenon. The localised sites of Fgf8 expression persist at least until birth and correspond to brain nuclei that regulate brain state including the Supra-chiasmatic Nucleus and Bed Nucleus of the Stria Terminalis that function as circadian pacemakers to determine daily activity patterns. We propose to study what role Fgf8 might play in regulating these clock regions and to what extent adult function represents a continuation of embryonic function.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Green Integrated Structural Elements for Retrofitting and New Construction of Buildings'.

assistant: **Objectives**

The Green INSTRUCT project will develop a prefabricated modular structural building block that is superior to conventional precast reinforced concrete panels by virtue of its reduced weight, improved acoustic and thermal performance and multiple functionalities. The Green INSTRUCT block consists of over 70% of CDW in weight.  The Green INSTRUCT project will: (i) achieve sustainability and cost savings through CDW sourced materials and C2C, (ii) develop efficient, robust, eco-friendly and replicable processes, (iii) to enable novel cost efficient products and new supply chains, (iv) develop a building block that renders refurbished or new buildings safe and energy efficient and (v) safeguard a comfortable, healthy and productive environment. They can be achieved by defining the structural, thermal and acoustic performance of our final product to be competitive to similar products in the market. The types and sources of CDW are carefully identified, selected and processed while the supply chain from the sources, processing, fabrication units to assembly site of the whole modular panel will be optimized. The project is guided by a holistic view through building information modelling and optimal overall performance. This includes considering the life cycle analysis, weight, structural performance, thermal and acoustic insulation, connectivity among modular panels and other structural/non-structural components as well as the compatibility of different internal parts of the each modular panel. In order to homogenize the production process, all individual elements are fabricated by extrusion which is a proven cost effective, reliable, scalable and high yield manufacturing technique. The concept, viability and performance of developed modular panels will be verified and demonst
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biogenicity of Martian Materials: critical assessment of biosignatures based on chemolithoautotrophic interactions' (BIOMAMA).

assistant: **Innovation**

The search for biologically driven alterations on Mars and its potential as habitat for past or present life is a primary aim of the upcoming Mars exploration missions. While a range of environments that would have been well suited to support a potential chemolithotrophy on Mars have been proposed, our understanding of putative biosignatures to be targeted in Martian materials is still poor. A valuable source of information can be extracted from microbial fingerprints of chemolithotrophic life based on Martian materials (Martian meteorites, regolith simulants). Chemolithotrophic microorganisms employ an astonishing number of metabolic pathways to extract energy from diverse inorganic electron donors/acceptors, shaping global biogeochemical cycles. Using a holistic approach based on laboratory, field and space exposure experiments, we propose to investigate interactions of Earths various chemolithoautotrophs with Martian materials. The bottom-up exploration of mineral-microbial interactions for different chemolithotrophs cultivated on Martian materials as the sole energy sources, will decipher mineral and metabolic biosignatures associated with these cases. This project explores unique microbial interactions with extraterrestrial materials down to the nanoscale and atomic resolution utilizing a comprehensive toolbox of cutting-edge techniques. BioMaMa will identify preservable biomarkers/biosignatures of chemolithotrophic life on Martian materials after the exposure to simulated Martian conditions at low Earth orbit and ground-based facilities. A complex approach will be used to investigate meteorite-microbial interactions in Mars-analogue sites on Earth. The extensive knowledge gained from BioMaMa will help to understand and critically interpret the results of future Ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Targeted Research action (TRA) on environmentally friendly construction technologies'.

assistant: **Concept**

TRA PROJECT OVERVIEW:The main objective of the TRA on 'Environmentally Friendly Construction Technologies' is to establish a well organised and efficient interface between the various construction related RTD projects supported by the EC. In particular the TRA aims at:- providing a European forum for the development, dissemination and exchange of scientific and technological knowledge and of ideas relating to all aspects of construction;- accelerating dissemination and exploitation of research results;- improving the synergy and coordination of research being carried out in EC programmesl;- informing RTD programme planners of the research needs and priorities of tomorrow. In the context of this proposal construction is understood to cover all economic activities which involve assembling or erecting fixed structures, plants or equipment, or earth movement on site.Construction thus includes: building construction, civil engineering (roads, railways, ports, waterways, bridges, towers, dams, tunnels, pipelaying, etc.) underground excavation, process plant and general steelwork construction , offshore structures, landscaping and land reclamation. Construction related topics embrace the total construction cycle, ranging from construction materials manufacturing to demolition and recycling of structures.EUROPEAN DIMENSION AND PARTNERSHIPThe expected added value for implementing the network can be classified in three categories: benefits for the research consortia, for the programme and for the Community;- For the research consortia real time exchange of mutually relevant information on technological aspects for increased future exploitation will be achieved, as well as increased motivation to achieve objectives and deliverables on time and cost, widening the scope of specific
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Screening protein translocation during cell differentiation with temporally multiplexed imaging' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

During differentiation, dramatic changes occur in the biochemical processes and the architecture of cells. The subcellular localization of proteins greatly impacts their function and also the transformations during cell differentiation are accompanied or facilitated by protein translocation. In the proposed research project, I want to systematically study how proteins translocate during the differentiation from neuronal stem cells into neurons and astrocytes. To this end, I aim to develop a general and efficient screening method for protein translocation during cell differentiation. I envision to identify protein translocation behavior that is essential for neurodevelopment and direct reprogramming, which I plan to confirm in brain organoids, which include diverse cell types. Additionally, I want to study the underlying mechanisms both initiating and initiated by protein translocation.The method will be based on fluorescence microscopy, which will allow me to observe the dynamics of protein localization in living, differentiating cells. To increase the efficiency of the  screening approach, I want to implement a recently published multiplexing strategy, temporally multiplexed imaging (TMI). This method uses the photo-switching kinetics of the utilized fluorescent protein (FP) labels to deconvolute up to 6 signals in a single spectral channel. In this way, I can label several proteins per cell multiplying the efficiency of the method and enabling the screening of a large panel of proteins. I will label these proteins with TMI-compatible FPs through gene editing. Imaging of the edited cells throughout the differentiation process and subsequent automated image analysis will identify translocating proteins. The gained mechanistic knowledge about neuronal cell differentiatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unlocking Pile Anchors Capacity and Resilience for Floating Wind Energy' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

UPCareWind will develop a new framework for pile anchor design to unlock hidden pile resistance and resilience, and to support the acceleration of offshore Floating Wind Turbine (FWT) deployment. FWT is a key technology for harvesting clean energy over deep water, with thousands of turbines required to meet EU climate neutrality goals, as 70% of the offshore wind technical potential lies in water depths greater than 50 metres. Steel pile anchors are currently the most frequently used in the mooring systems that keep FWTs in place. Current design guidelines define pile resistance as the force measured at a pile head displacement equal to 10% of the diameter (D), based on conservative onshore design guidelines. However, since offshore mooring systems with >100 metre-long mooring lines can tolerate much larger displacements, much higher peak anchor resistance can be unlocked by allowing displacement of >100%D. As a result, smaller piles can be manufactured to provide equivalent design forces, saving billions in steel and installation vessel time. UPCareWind will combine advanced physical (geotechnical centrifuge) and numerical modelling (Discrete Element Method) to quantify pile peak and post-peak resistances across a wide range of geometrical, loading and soil configurations, establishing a unique and novel database. This database will be used to develop and calibrate a new pile anchor design framework, which will be provided in open access to geotechnical practitioners. The project has dual ambition: (1) to redefine the concept of failure for pile anchors and make it a new design standard, and (2) to embed resilience in design by quantifying residual pile resistance after extreme weather events. UPCareWind will contribute to unlocking new areas for FWT development, and u