RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The contribution of mycorrhizal fungi to multifunctionality in global drylands'.

assistant: **Innovation**

Dryland ecosystems are a key terrestrial biome, covering 45% of the Earth´s surface and supporting over 38% of the total global population, but their functioning and the goods and services they provide are vulnerable to global environmental changes such as increasing land use intensity (e.g. grazing pressure) and climate aridification. Mycorrhizal fungi, i.e. obligate plant symbionts colonizing the roots of 90% of all land plants, contribute substantially to dryland biodiversity, to their functioning, and the provision of goods and services by dryland ecosystems. In exchange for plant assimilated carbon, mycorrhizal fungi increase plant nutrient supply, influence soil formation and aggregation, plant defence to herbivory and resistance to drought, among other important processes. Through these mechanisms, they influence plant diversity, multiple ecosystem functions, such as nutrient cycling or biomass production, and likely modulate ecosystem responses to aridity and grazing pressure, which are forecasted to increase in drylands under global environmental change. Mycorrhizal effects depend on environmental conditions and species traits determining the efficiency of the resource exchange between plants and fungi. However, to date little is known about the contribution of mycorrhizal fungi to the diversity and functioning of drylands or to the capacity of drylands to provide multiple functions simultaneously (i.e. multifunctionality). We also do not know how the contribution of mycorrhizal fungi to dryland multifunctionality might change under forecasted global environmental change or depending on the resource economy of the plant community. The MYFUN project aims to fill these gaps in knowledge by assessing the contribution of mycorrhizal fungi to dryland multifunctional
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Microencapsulation for low cost, high volume, pharmaceutical applications' (MICROCAP).

assistant: **Innovation**

The project set out to produce a guidance manual containing all the experimental microencapsulation Work carried out by the partners. This was completed successfully and is fully accessible on a ftp site: www.microlithe.com/manual A network web site was also created and contains such information as: partners web site links, events, contacts, and a members section which is accessible by means of password only.Microencapsulation is of interest to a wide range of industries, including pharmaceutical. cosmetic, food, chemicals and printing. This network will provide a focus for research into microencapsulation in the EU. There are three main issues which the network will address: * the high cost of microencapsulation which limits its use for many applications; * the confusing number of microencapsulation techniques; * the need for more environmentally friendly microencapsulation. The network will therefore evaluate low cost and solvent free microencapsulation techniques, and will provide a guidance manual for EU industry to indicate which technique is most suitable for particular applications. For additional focus, most of the work of the network will have a pharmaceutical/healthcare orientation. This is also because companies in this sector are more likely to cooperate in a network. However, as the same microencapsulation techniques are used in many industries, the results of the network will be of immediate multi-sector use. The network comprises 30 members which have been organised into four clusters grouping members with similar interests. The profile of the network membership by type is as follows; SMEs : 15. Large industrial companies : 3. RTOs : 6. Universities : 6. The network includes SMEs specializing in microencapsulation and related technologies, materials suppl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Constructing the Danish Colonial State in Global Contexts' (CoDaCo).

assistant: **Innovation**

This project provides the first global intellectual history of Denmark as a colonial state. Utilising an innovative methodology combining global intellectual history and the history of knowledge, the project will show how a series of reforms in Denmark and the Danish colonies 1784-1807 aimed at (re)constructing Denmark as a coherent colonial state, an empire in global contexts. It will show how the discourses of natural law and statistics were a key intellectual resource in this endeavour, drawing on networks circulating and producing colonial knowledge. Thus, the project will make an innovative contribution to global intellectual history, the history of Scandinavian colonialism, and the history of knowledge, as well as a path-breaking re-inscription of Denmark into its early modern global history. It will be carried out at a university that is the most thriving research environment on Scandinavian colonial and global history, and history of knowledge. Finally, it is specifically designed to provide the scholarly output and training needed to advance my career onto the next, crucial step.


**Keywords:** State Building, Empire, Global Intellectual History, Denmark, Greenland, India, West Africa, Caribbean
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Organotypic brain slice cultures as alternatives to in-vivo experimentation in the study of brain repair mechanisms.' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Currently the demand for animal testing is increasing in both the pharmaceutical and academic sectors driven by a vast increase in the numbers of potential new drug targets following the advances in genomic and polemic technologies and new organic synthesis methods. The present proposal will develop specific methodology and new chronic in-vitro models of traumatic brain injury and stroke that allow for the study of neurodegenerative mechanisms as well as mechanisms of brain repair in organotypic brain slice cultures. These systems will present attractive alternatives to comparable in-vivo models for basic and applied research, reducing the need to carry out in-vivo tests. At the same time they will help industry tore fine and improve the selection of compounds, which subsequently must be tested in-vivo before entering clinical trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Phenotypic characterization of Liver-derived exosomes populations associated with liver metastasis in pancreatic cancers' (ONCOSYSTEMS), addressing dissemination and exploitation.

assistant: **Impact**

Tumors are not isolated entities, but complex systemic networks involving cell-cell communication between transformed and non-transformed cells. The milieu created by tumor-associated cells may either support or halt tumor progression. Non-tumor cells also play a role at distant sites, preparing future metastatic sites to support engraftment and survival of metastatic cells. In addition to cell-cell contact, cells communicate through secreted factors via a highly complex system involving characteristics such as ligand concentration, receptor expression and integration of diverse signaling pathways. Of these, extracellular vesicles such as exosomes are emerging as novel cell-cell communication players in physiological and pathological scenarios. We recently described that exosomes produced by highly metastatic pancreatic cancers (PC) induce Liver Pre-Metastatic Niches (LPMN) supportive of hepatic metastasis. Although we defined how LPMN are induced by PC-derived exosomes, the specific mechanism of how the LPMN support the formation and progression of liver metastatic lesions is still unknown. In addition, while we have been showing that pre-metastatic niches support metastatic spreading, we still do not have appropriate means to detect the formation of these niches by non-invasive methods in clinical settings. Thus we propose to: 1)Characterize the composition of liver-derived exosomes populations in physiologic and LPMN-associated settings by applying state-of-the-art flow cytometry tailored to nanoparticles analysys at a single-exosome level; 2)Test whether liver-derived exosomes interact with metastatic PC cells and play a role in supporting the progression of PC metastatic lesions in the liver. This project has the potential to offer not only a non-invasive alternati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Membrane partitioning of homologous proteins' to be submitted under Seventh Framework.

assistant: **Abstract**

My goal is to elucidate how structurally closely-related proteins are selectively partitioned in distinct membrane domains that allow localization, clustering and segregation of specific cellular activities. Although many of the mechanisms that govern membrane organization are increasingly well understood, such as lipid ‘rafts’ or protein-anchoring to the cortical cytoskeleton, these mechanisms are not sufficiently specific to account for the partitioning of closely homologous proteins in separate membrane domains. I believe that the observed highly selective membrane partitioning can only be explained by the combined action of protein-protein and protein-lipid interactions and thermodynamic properties of the membrane (length, charge, degree of hydrophobicity). I aim to gain a full understanding of how homologous proteins partition in distinct functional membrane domains by studying SNARE proteins as a model system. Different SNAREs partition in different domains with different degrees of overlap in the plasma membrane where they catalyze the final membrane fusion steps of various exocytotic pathways. I will employ quantitative super-resolution microscopy to study the effects of selective (biochemical and genetic) perturbations on SNARE partitioning in both precisely controllable artificial membranes and in PC12 cells. This will allow me to elucidate the mechanisms, contributions and interplay of individual membrane clustering mechanisms in SNARE domain organization. I then plan to demonstrate that the mechanisms of SNARE partitioning explain the membrane organization of other (homologous) proteins as well. My ultimate ambitious goal is to generate a complete model of how proteins are organized in biological membranes. I anticipate that my findings will uncover new and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Building minimal cells to understand active cell shape control' (MINICELL).

assistant: **Concept**

Understanding how cells control their shape is an important scientific goal, since cells in our body constantly need to undergo shape changes to perform vital tasks such as growth and division. Conversely, abnormal cell shape changes contribute to life-threatening diseases such as cancer and developmental disorders. I propose to resolve the physical basis of active cell shape control by studying minimal cells built from purified cellular components. The main determinant of cell shape in animals is the actin cortex beneath the cell membrane, which contains molecular motors that actively generate forces. There is growing evidence that cells tightly balance these active forces with passive forces arising from cortex-membrane adhesion and elasticity. However, it is unclear how these forces are generated and controlled on the molecular level given the enormous complexity of cells. To circumvent this complexity, we will reconstitute cell-free actin networks and couple them to model biomembranes with the essential cellular linker protein septin. Using various advanced microscopy techniques, we will study (1) how active cortical networks and lipid bilayers influence each other’s spatial organization; (2) how active cortical networks control membrane shape; and (3) how spatial gradients in cortex contractility can cause cell shape polarization. My long-term ambition is to bridge the gap between the physical properties of cell-free model systems and biological functions in living cells. Thanks to recent breakthroughs in our understanding of the biophysical properties of contractile actin networks, we can now build more relevant cell-free model systems that can mimic active cell shape changes. To test the biological relevance of our findings, we will confront our results with live
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Treat Iron-Related Childhood-Onset Neurodegeneration', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Neurodegeneration with brain iron accumulation (NBIA) is a heterogeneous group of rare hereditary neurodegenerative disorders characterized by high levels of brain iron. The most common form is pantothenate kinase-associated neurodegeneration (PKAN). Classic PKAN and most other NBIA cases are characterised by early childhood onset and rapid progression. Currently, there is no proven therapy to halt or reverse PKAN or any other NBIA. This is especially unfortunate as both the iron accumulation in NBIA and the biochemical defect in PKAN are predicted to be amenable to drug-based treatment. Thus, the current absence of clinical trials is not due to lack of therapeutic options but to rarity of the disease, lack of patient registries and fragmentation of therapeutic research worldwide. For example, the iron-chelating drug deferiprone has been administered to PKAN patients on an individual basis or in pilot trials, both precluding firm conclusions about its efficacy. With TIRCON, we will address this urgent and unmet need for NBIA/PKAN therapy with an ambitious and highly collaborative plan that leverages worldwide expertise. We propose a large investigator-driven randomized clinical trial of deferiprone in PKAN, bringing together leading centres and patient advocacy groups from Europe and the US to reach the required patient cohort size. In addition, together with a European SME, we propose to pursue preclinical development of pantethine and its derivatives which have shown promising efficacy in a Drosophila PKAN model. To facilitate future research, we will develop a harmonized patient registry and biomaterial bank to allow for natural history studies and biomarker development, two critical needs in NBIA research. TIRCON partners, apart from their unique clinical and basic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'An interdisciplinary genome-wide study of posttranscriptional regulation by small RNAs: from individual interactions to networks and evolution'.

assistant: **Concept**

Deciphering the interactions within and between the three major components of living organisms, DNA, RNA and Protein, is at the heart of biological research.  New large-scale experimental methods have dramatically advanced genome-wide detection of protein-protein, protein-DNA, protein-RNA and protein-mediated RNA-RNA interactions. However, at present there is no large-scale method that could detect all RNA-RNA interactions independent of a mediator protein, or when the mediator protein is unknown.  Attaining such a method is of utmost importance and is very timely, as it is now evident that RNA-RNA interactions play central roles in cellular life. In particular, hundreds of expressed small RNA (sRNA) molecules were discovered in both pro- and eukaryotes, many of which act as posttranscriptional regulators of gene expression by base-pairing with their mRNA targets. It seems that in many organisms the layer of posttranscriptional regulation is as widespread as transcription regulation, presenting a major challenge towards achieving functional and mechanistic understanding of this regulation level. Here we propose to develop an innovative methodology for genome-wide detection of the sRNA targetome, all mRNA targets of cellular sRNAs. This new methodology combines in vivo structural probing with deep sequencing and is independent of protein considerations. We will apply this method to deciper the sRNA targetome of the model organism Escherichia coli, which encodes over 100 sRNAs.  We will use the sRNA targetome data as the foundation for a systematic ‘bottom-up’ computational analysis of multifaceted aspects of sRNA-mediated posttranscriptional regulation, encompassing the basic underlying rules of sRNA-mRNA target recognition, the design principles of the posttranscription
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Next-Generation Quantum Key Distribution for a Secure Digital Future' (NEXUS), addressing dissemination and exploitation.

assistant: **Impact**

In an era of unprecedented digital threats, Europe faces a critical cybersecurity crisis. The coming of quantum computers threatens to render current cryptography methods obsolete, potentially exposing sensitive government, financial, & personal data to malicious actors. This is compounded by the “harvest now, decrypt later” strategy, where adversaries stockpile encrypted data for future decryption, jeopardizing long-term data security.Q*Bird addresses this crisis with our groundbreaking Measurement Device Independent Quantum Key Distribution (MDI-QKD) technology. Unlike traditional QKD systems, our solution offers unparalleled security, scalability, & cost-effectiveness. Our multi-point-to-multi-point architecture enables easy network expansion, dramatically reducing per-user costs while maintaining quantum-safe security. This innovation not only safeguards against current and future quantum threats but also lays the foundation for the emerging Quantum Internet.A European deep-tech startup, Q*Bird is uniquely positioned to contribute to the EU's technological sovereignty in this critical domain. Our technology aligns perfectly with key EU initiatives such as the European Quantum Communication Infrastructure (EuroQCI) and the Cybersecurity Strategy for the Digital Decade. However, the high-risk nature of quantum technology development, coupled with long commercialization timelines, creates significant challenges in securing sufficient private investment.EIC Accelerator support is crucial to bridge the gap between our current prototype and full commercialization. This support would not only accelerate our technology development but also catalyze additional private investment, enabling Europe to lead in the quantum communication revolution. With EIC backing, Q*Bird can tr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DETECTION OF UNDERWATER OIL SPILLS' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The result of the project will be an autonomous monitoring system for the purpose of on-site detection and evaluation of oil leakages in underwater offshore-installations. The system is based on a hydrocarbon sensor initially developed for scientific purposes. The system allows the early organization of adequate intervention. It is particularly suited in regions (deep-water, artic) difficult to access and at a distance from operation control facilities. Benefits are in production, safety and cost.