RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Improving jet fuel efficiency through automated, high-precision and performance of engine manufacturing' (AERO).

assistant: **Innovation**

The aviation sector is a truly global economic force in Europe, contributing with 2.1% of its GDP and 5 million jobs, and it is expected to continue to grow by a further 45% by 2035. However, it is also a great polluter, as fuel burned releases GHG emissions into the atmosphere. To limit it, global and European bodies are enforcing obligations for aircraft OEMs to meet emissions limits by 2023, expected to be achieved by reducing the fuel consumption through more efficient engines and lighter materials. To accomplish this, the aerospace industry currently uses the Investment Casting process to manufacture some complex components of jet engines components. Whilst this process represents the current industry standard, it comes with limitations that is reducing the potential for enhancing aerodynamics and using lighter materials, key to increase engine’s fuel efficiency. At TPC we are developing the new standard, the Investment Vacuum Process, that will allow to use lighter materials, simplify the manufacturing process whilst reducing costs and reduce time from development to market. This industry is highly specialised and historically 90% of the European market is dominated by 3 non-European foundries (2 Americans and 1 British). At TPC we not only aim to introduce the new industry standard to allow aircraft manufacturing companies meet the new regulations, but also to introduce competition into this highly dominated market, reducing dependency and increasing competitiveness in the EU. TPC is the leading foundry in Sweden. AERO project aims 1) to raise TPC´s capability to a comparable level with the current state of the art technology level of the “Big 3” and 2) to put TPC into a leading position as a VIC foundry in Europe. We are already supported by the industry as have
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Virtual Multimodal Museum' to be submitted under Horizon 2020.

assistant: **Abstract**

Virtual Multimodal Museum (ViMM) proposes a major, high-impact CSA across the field of Virtual Museums (VM), within the overall context of European policy and practice on  Virtual Cultural Heritage (VCH).  A highly expert seven (7) partner consortium will leverage the support of a unique and powerful Advisory Group, consisting of many of the Europe and the world’s leading public and private sector organisations in the field, to define and support high quality policies, strategic and day-to day decision making, the utilisation of breakthrough technological developments such as  VR/AR and to nurture an evidence-based view of growth and development impacted by VM, supported by a set of case studies in culturally-rich regions of South Europe affected by economic recession.Its work will be founded on building a consensual framework directly involving Europe’s leading VM decision-makers and practitioners in defining and resolving existing issues spread across 7 interlinked Thematic Areas (‘the 7 Ds’): Definitions – Directions – Documentation – Dimensions – Demand- Discovery - Decisions and will result in wide-reaching stakeholder participation and very high visibility. The latter will be achieved through organisation of key events at policy and practitioner/stakeholder levels, extensive use of the media, and by the introduction of a highly interactive and wide-reaching communication platform, deploying social media and novel approaches to enable focused debate by all interested parties, supported by access to representations of excellence and a decision-support tool for stakeholders.An initially broad and open approach will be refined through a process of definition, consolidation and resolution activities to arrive at a clear Manifesto and Roadmap for Action on VM, validated
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Dissecting chromosomal instability in gastric cancer and its role in immunoediting using advanced functional and multiplexed single cell sequencing technologies', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Chromosomal instability (CIN) is a main cause of tumor heterogeneity, tumor evolution and therapy resistance of cancers. Chromosomally instable gastric cancer (CIN-gastric cancer) accounts for 50-70% of gastric tumors and is the poorest prognosis tumor subtype with the most suppressed tumor immune microenvironment. However, it is not understood how CIN contributes to poor prognosis and edits the tumor immune response of CIN-gastric cancer, due to a lack of assays investigating native CIN-driving mechanisms at the single cell level.I invented a pioneering, microscopy-based functional single cell sequencing method, which enables selective profiling of rare subpopulations of cells displaying dynamic phenotypes of interest. In this proposal, I will use my expertise to develop novel advanced single cell and multiplexed sequencing methods and create a new research line with the aim of dissecting the driving mechanisms of CIN in CIN-gastric cancer, investigating the impact of CIN on tumor microenvironment, and elucidating the molecular pathways leading to the poor prognosis of CIN-gastric cancer. To fulfill this aim, I defined three research objectives:In Objective I, I will develop a deep learning-based functional single cell sequencing (deepFUNseq) method to identify and profile rare, naturally occurring CIN-mother and -daughter cells derived from CIN-gastric cancer patients. In Objective II, I will develop a multiplexed functional & spatial single cell sequencing method(multi-FUNseq) to transcriptomically profile (non-)CIN gastric cancer cells and their interacting immune cells.In Objective III, I will investigate CIN-driving mechanisms and CIN-associated consequences in CIN-gastric cancer, including the role of CIN in immunoediting.The technologies developed in this propos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Functional genomics relating to the biosynthesis of trypanosome glycoconjugates' under Sixth Framework.

assistant: **Concept**

The African trypanosome Trypanosoma brucei causes African sleeping sickness and the cattle disease nagana. The human and socio-economic impact of these diseases is considerable. The available drugs for humans are inadequate and difficult to administer. Parasites are very dependent on glycoconjugates for their survival and infectivity. The main goal of this project is to determine the function of genes involved in galactose-containing glycoconjugate biosynthesis and processing in T. brucei.The emerging T. bruce i genome will be systematically mined, and the candidate genes classified in different glycosyltransferase (GT) groups. Representative examples of these putative GTs will be experimentally examined by inducible RNAi knock-downs, by gene knockout, or by construction of tetracycline-inducible conditional null mutants. Mutant cells will be assessed for growth in vitro and for infectivity in vivo. Moreover, mutant cells will be bio-chemically phenotyped in both the blood stream and procyclic lifecycle forms of the parasite. In this way, we should be able to assign precise functions to genes and thus, identify sequence motifs/patterns that discriminate between different families of parasite enzymes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Chiral-Induced Spin Selectivity Effect'.

assistant: **Innovation**

Chirality is often considered as a structural properties of molecules, but the concept also applies to elementary particles having a non-zero spin, i.e. electrons at rest are achiral but they acquire a helicity (chirality) in the direction of motion. Consequently, electrons are filtered according to their spin when crossing chiral materials. This newly uncovered chiral-induced spin selectivity (CISS) effect is surprisingly large. Spin polarization up to 100% has been demonstrated paving the way to multiple applications in chemistry, such as improved control of enantioselective reactions and easier separation of enantiomers. Impacts are also expected in physics (spintronics) and biology (molecular recognition of biomolecules, origin of bio-homo-chirality, magnetic compass of migratory songbirds). CISS effect is theoretically ill-defined. Sound structure-property relationship lacks also for the link between molecule chirality and CISS effect magnitude. CISSE proposal intends to contribute to a giant leap forward in the knowledge of CISS effect by putting together some of the best European, American and Israeli experts of the field, who will work towards its fundamental understanding. To this end, members of the CISSE consortium have been selected for their expertise and complementarities encompassing: synthetic chemistry, electrochemistry, surface science, bio-physical chemistry, quantum chemistry, nanoscience, industrial processes, analytical chemistry, and scientific instrument developments. Importantly, some beneficiaries have filled the first patent applications on CISS effect and have started to valorize them. Considerable scope for new discoveries and invention remains because the field of CISS effect is still in its infancy. The topic is particularly suited to educ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Development and trafficking of type 1 and type 17 mucosal-associated invariant T cells' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Mucosal-associated invariant T (MAIT) cells colonize mucosal tissues where they become tissue-resident and have important protective and homeostatic functions. MAIT cells are selected in the thymus by microbial metabolites presented by MHC-related protein 1 (MR1) on thymocytes thereby acquiring an effector phenotype (type 1 or 17). This project aims at elucidating mechanisms that regulate the last stages of thymic MAIT cell development, including their egress, and identify cues necessary for tissue colonization. Specifically, we will couple transcriptomics and thymus transplantation models to analyze canonical thymic MAIT cell development, thereby identifying new regulators of the MAIT1/17 fates, as well as to identify MAIT cells that recently exited the thymus and seeded mucosal organs, thereby identifying new regulators of tissue adaptation. These targets will be functionally tested in models combining CRISPR/Cas9 encoded by lentivirus with bone-marrow chimeras or adoptive transfers. Additionally, we will determine the identity and dynamics of MAIT cells exiting the thymus to colonize tissues by combining different experimental approaches including in vivo EdU/biotin labeling, thymectomy and blockage of thymus egress. Lastly, we will address whether MR1–microbial metabolites are required for the maintenance of MAIT cells in tissues at steady-state using mono-colonization/decolonization of germ-free mice and by conditionally ablating Mr1. Overall, this work will uncover fundamental mechanisms underlying MAIT cell development and tissue colonization. Albeit outside the scope of this work, it is possible that the mechanisms uncovered here may have implications in other innate-like T cells or for the establishment of mainstream tissue-resident T cells.


**Keywords:** Muc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Metrology for future 3D-technologies' in the context of a Horizon 2020 call.

assistant: **Objectives**

Within the food chain of equipment delivery for the semiconductor industry, Europe has kept a very strong position in the metrology area with many companies establishing themselves as main leaders in the field. Hence in line with the objectives of the ICT25 call for innovation action  to overcome the (initial) barriers for the successful commercialization of novel European products, this project aims at exploring for a number of metrology solutions their technological readiness, reliability and relevance of the developed protocols, and the COO. The portfolio within the project covers new metrology concepts addressing specifically the processing challenges linked to 3D-Devices and range from probing basic layer properties (composition, electrical properties) in FEOL to control of metallization in BEOL up to issues linked to die stacking. Due to the specific processing steps which need to be addressed, three separate metrology tools will be assessed in this project i.e a Tofsims system (IonTOF) with build-in Scanning Probe stage and FIB column for true 3D-composition profiling, a completely automated micro-Hall and sheet resistance measurement tool (Capres) with additional capabilities for measurements on  dedicated test structures (prior to full BEOL) and an GHz acoustic Microscope (Tepla) for probing voids in TSV’s and stacked dies. As some of them (IonTOf, Capres) are addressing partly complementary information (composition versus electrical properties), their co-existence in this project creates additional value as beyond the tool assessment also a methodology based on combining these concepts can be explored and certified. Moreover a significant efficiency gain is created as they can employ similar test structures and devices. For each of these tools, the basic metro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovation Associate knowledgeable in blockchain technology for real time economy platform business development' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

DLI Ltd operates right now in a synergetic business landscape where the development of national information society and the client assignments collide in a manner profitable for the company. DLI Ltd need to complement its expertise with knowledge in blockchain technology for secured Real Time Economy in cloud, both in general for providing applications to any client and for piloting the DEEP, Digital Enterprise Ecosystem Platform business plan on open innovation with a client in the FinTech. The plan targets to leverage the business plan further within the client’s global organization, one of the world's largest settlement system for domestic and international securities transactions.The employment of the Innovation Associate will base on the mutually developed and agreed Personal Career Development Plan which will be first time discussed during the recruitment phase together with the Training Plan suggested by the company. The personnel of DLI Ltd offer an innovative working environment in a team of professionals in production design and software development as well as ecosystem builders, innovators and people with a high academic degree familiar with practicalities in science. Street smart business out of latest in science meets at this knowledge intensive SME. The Innovation Associate is free to use her or his full potential to contribute to the client assignments and to the tasks in the workplan, as well as to create a career of her or his own at DLI Ltd on the generated Innovation Plan in long run.As the DLI Ltd’s LifeEngine platform is applicable in any field and DLI Ltd is highly skillful in ecosystem building with stakeholders of the full operational chain, DLI Ltd has appealed clients in demand of latest and future Internet technologies in several fields. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The Brain Dynamics of Human Fluid Intelligence' (NEUROINTELLIGENCE).

assistant: **Concept**

Human fluid intelligence is characterized by a structured sequence of cognition, resulting in efficient application of rules to novel problems. In the brain, metabolic neuroimaging and lesion studies have linked fluid intelligence to a specific frontoparietal network, here called the multiple-demand (MD) network, comprising regions of lateral frontal, insular, dorsomedial frontal and parietal cortex. But how do MD functions determine fluid intelligence across stages of cognition? My extensive expertise in electroencephalography (EEG) source analyses and neural pattern classification techniques will allow me to assess time-resolved neural representations of novel rules in MD and perceptual cortex as a function of fluid intelligence, as well as the causal impact of MD cortex on earliest stages of perceptual encoding. Higher- and lower-intelligent subjects’ electrophysiological (EEG) and behavioural measures of novel rule implementation will be systematically analysed. Non-invasive neural stimulation (transcranial magnetic stimulation (TMS)) will be used in combination with EEG to draw causal conclusions on the specific role of MD and perceptual cortices in human fluid intelligence. My novel analysis approach may provide a new account on fluid intelligence: one aspect of low fluid intelligence may be the dysfunctional early filtering of task-relevant information in perceptual cortex, due to lack of top-down control from MD cortices, leading to sensory overload on later processing stages. The proposal’s outcomes will be both of high academic and commercial interest. Understanding the brain signatures underlying fluid intelligence is essential for more specific and cost-effective medical interventions. For example, decline of fluid intelligence due to healthy ageing is stron
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Non-toxic, non flammable, recyctable composite in shipbuilding element'.

assistant: **Concept**

We have developed a material, which is possible to use like polyester resin, but it do neither burn nor it is not toxic ( any component) nor includes petrochemicals. The aim of this project is based on this material to develop Non-toxic, Non flammable, Recyctable Composite used in shipbuilding elements. The authorities insist on the firesafety of the interior materials. When the demands become stricter, it is essential to develop new materials, because it is not possible to use the old ones. To day the only certified wall elements in ships are made from two short steel sheet coated with PVC and a mineral wool in the middle glued to each other called steel casets. They are heavy and old-fashioned. Therefore it is a necessary to develop a new certified wall element in ships - shipyards insist it.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Demographic Behaviour and Modernisation in Spain, 1870-1960' (1994-1998).

assistant: **Innovation**

Research objectives and content The significance of the demographic transition for the modernization of European societies and for the make-up of today's world, together with the inherent weaknesses of the theoretical formulations which are normally used to explain it, have encouraged us to make use of innovative analytical perspectives in the course of the present project Our basic hypothesis is that the ubiquitous use of aggregate date to explain and interpret changes in people's demographic behaviour will never yield truly satisfactory results. A perspective based on the experience of individuals and their families will prove to be far more useful, as long as we can control for the social, economic and cultural characteristics of those individuals, their families and their community. Having obtained the necessary legal permit, access has been secured to the Civil Register of the towns of Aranjuez andof Torrelaguna (Madrid) whose books have been microfilmed for this project. With these data, a family reconstitution will be undertaken between 1871 and 1960, a period covering the entire process of demographic modernization. Complementary data bases on the social, economic and educational characteristics of individuals and of families, as well as on the height of military draftees will be generated. Once the requisite data bases are ready, a number of studies will be carried out on the transition of fertility and mortality from a micro-analytical perspective, in terms of the timing and intensity of demographic change on the one hand, and the age, occupation, migratory status, literacy, family situation, etc. of the individuals involved in those changes.Training content (objective, benefit and expected impact)With these data in hand, we will be le to identify, for example