RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Role of Mobile Genetic Elements in the Spread of Antimicrobial Drug Resistance' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

Mobile DNA provides a major contribution to the spread of antimicrobial resistance, by recruiting new resistance genes in bacterial pathogens and facilitating their horizontal spread. While much is known about individual resistance genes and mechanisms, the nature of the mobile elements and their transfer mechanisms have been clarified only in few cases, and very little is known about their molecular epidemiology. A comprehensive understanding of these aspects could provide a significant breakthrough toward combating dissemination of resistance determinants.The DRESP project aims at investigating these aspects, focussing on few major families of genetic elements that carry a number of important and emerging resistance determinants: i) the double resolvase elements (DR-elements) of gram-positive cocci, involved in spread of mefA genes; ii) the related DR-elements in Gram-negative cocci, an entirely novel type of mobile element; iii) the vanA and mefE conjugative transposons; iv) the integrons; and (v) resistance plasmids.The GENERAL OBJECTIVES of DRESP are: a) to investigate the molecular epidemiology and metagenomics of selected families of mobile elements in clinical strain collections and environmental samples; b) to carry out structural and functional analysis of these genetic elements to elucidate transfer mechanisms and their regulation, and to identify possible common molecular themes underlying these functions; c) to promote Information-Sharing and dialogue to stakeholders as to increase the social value and impact on pubic health of the knowledge gained.EXPECTED DELIVERABLES of this project are: (i) new information on the spread of mobile elements carrying resistance genes, and mechanisms thereof; (ii) new techniques for molecular epidemiology studies; (iii) nov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Analysis of myelinated axon development in zebrafish' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Myelinated axons are an essential component of the vertebrate nervous system. Myelin is a plasma membrane extension of specialised glial cells that wraps around axons to facilitate the rapid conduction of neuronal impulses. Disruption of myelinated axons contributes to the symptoms of numerous human diseases, such as Multiple Sclerosis (MS). Our understanding of the molecular and cellular mechanisms that co-ordinate myelin formation and those that contribute to the progression of human diseases of myelinated axons such as MS remain rudimentary. We have helped establish the zebrafish as a powerful laboratory organism with which to dissect myelin formation. Through a forward genetic screen we identified ten genes essential normal myelinated axon formation. We identified new roles for genes previously implicated in myelinated axon development, isolated two completely novel regulators and identified mutations in four genes relevant to human diseases of myelinated axons. Disruption to the human homologue of one of those genes, kif1b, was recently associated with MS, and our initial studies identified important roles for this protein in myelinated axon formation. In this proposal we ask for support to continue our analysis of kif1b function. Although our genetic screen was a success it did not approach saturation and additional screens would clearly identify other factors essential for myelinated axon development. Gene discovery screens, however, take a long time to carry out, are quite labour intensive and can preclude the identification of mutations in genes required for multiple stages of development. In this proposal we outline novel methodologies to identify protein function in biological processes of interest by combining high-throughput screening of the phenotypic effe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Integrated information and process management in manufacturing engineering' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The basic objective of OPAL is to provide a concept for high-level integration of processes and information in the domain of engineering and production. The current level of integration is inadequate, because of the heterogeneity of information system components and data formats used to represent engineering information.Many processes concerned with product development, product industrialisation, manufacturing and assembly are driven by heavy use of paper-based engineering information. As today's market becomes increasingly dynamic, internal information flows within companies are increasing, this paper-based handling and management of information processes is less able to meet these companies' needs. The integration requirements of these heterogeneous information and system environments have to be thoroughly studied, and concepts provided for a robust solution.The information technology components important to all types of engineering information are the administration systems which are used to store and manage them, and to provide access to them. In industrial companies and co-operating networks of companies many different kinds of data administration systems occur, e.g. various kinds of databases, hierarchical, relational and object-oriented, product data management systems (PDMS) which may also be called engineering data management systems (EDMS).The approach taken is OPAL is as much as possible to use existing methodologies and techniques to bring the right concepts together to provide a robust integration approach. Regarding integration, emerging vendor-independent concepts like DCE and CORBA are considered as a basis to implement an open architecture for integrated information and process management.The OPAL open architecture will provide an umbrella, presenting i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Universal Flu Vaccine'.

assistant: **Objectives**

Currently licensed influenza vaccines promote an effective antibody response, but only against influenza virus strains that antigenically match the vaccine composition. Little protection is induced by these vaccines against antigenically drifted strains such as those emerging from an avian or swine reservoir. Hence there is a great need to develop broadly cross-reactive flu-vaccines.The aim is to establish a European training platform to integrate young researchers in a highly innovative interdisciplinary strategy to develop mucosal flu-vaccines. The Universal Influenza Vaccine (UNIFLUVAC) network is aimed at harnessing the expertise of the most accomplished vaccine researchers, developers and regulators in Europe in a timely and multidisciplinary training approach unparalleled in any single EU country. The training program is extensive and builds on the integrated added values of complementing expertise and the full access to state-of-the- art technologies and excellent training environments. This unique consortium has 2 SMEs as fully committed members to guarantee strong intersectoral cooperation between industry and academia.The partners represent 6 leading universities in 6 different member countries, securing excellent presence in Europe. The structure of UNIFLUVAC is specifically adapted to operate over the whole range of specialized expertise needed. Specifically, UNIFLUVAC provides vaccine antigen identification and expression, adjuvant design and formulation, testing in state-of-the-art preclinical animal models and finally clinical safety, immunogenicity and efficacy trials in excellent and for Europe unique medical centres. This is the strength and appeal of the UNIFLUVAC proposal. It will also establish a long-term European network based on a new cohort of y
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project '(Sustainable) Strawberry Fields Forever: Harnessing plant volatiles and optimizing agricultural practices in the management of pathogens in a strawberry production system in Sibate, Colombia' (Sustainable) targeting Horizon Europe.

assistant: **Abstract**

Smallholder farming plays a crucial role in the food security and socio-economic stability of rural communities. However, their success is highly dependent on the profitability of crops, compelling farmers to intensify farming practices and widen profit margins. In the smallholder farming community of Sibate, Colombia, strawberry production has greatly increased over the past 2 decades. However, this crop is sensitive to infection by fungal pathogens, such as grey mould (Botrytis cinerea) and red stele disease (Phytophthora fragariae), of which outbreaks can decimate harvests. The intensive application of costly chemicals and expansion of cultivated lands to mitigate losses has led to the pollution of arable lands and threatens the endangered, highly biodiverse paramo ecosystem. I aim to provide the fundamental knowledge needed to develop sustainable management strategies and provide accessible information to promote its implementation. My first objective is to develop a causal model to predict disease outbreaks in the strawberry production system, with the aim of reducing the use of agrochemicals and optimizing irrigation practices. My second objective is to provide an alternative pathogen management strategy by making use of plant volatile organic compounds (VOCs). VOCs emitted by infected plants can be detected by healthy plants and invoke a pre-emptive immune response. I aim to explore whether VOC-induced immune responses can be used as a “green vaccine” in strawberries under the Sibate environmental conditions. My third objective is to develop a web-application that predicts disease outbreaks, in collaboration with the farmers, so that cost-effective and pesticide-reduction management will be implemented. Together, this project aims to become a showcase to develop
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'VALORIZING OF LACTOSE BY ENZYMATIC CONVERSIONS TO COMPOUNDS WITH APPLICATION IN THE FOOD AND NON-FOOD INDUSTRIES' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

One of the most significant problems with regard to economics and environmental impact faced by the dairy industries is the disposal of lactose in whey and whey permeates. Lactose is a low value sugar accounting for up to 75% of the total dry material in whey and accumulates in annual quantities of approximately 1.2 million tons worldwide without many profitable routes for its direct utilisation being available. Lactose itself has a very weak marketing potential due to several reasons with lactose intolerance of the consumers being probably the most important. As a consequence there is a clear need for research to develop uses for lactose including conversion processes to more valuable products than the parent compound. These processes in turn could serve as the basis for new industries and will improve the EU competitiveness in the versatile area of lactose-derived products. The present project is a highly multidisciplinary approach to enzymatic lactose conversion processes with definite industrial potential and therefore calls for a consortium of European dimension. The project will focus on three major objectives. First, the project is aimed at improving existing chemical or biotechnological routes to lactose-derived products in terms of productivities and process economy. Integrated activities with regard to new biocatalyst including the tailoring of enzyme properties by protein engineering and the optimization of the corresponding reaction engineering employing high-productive combination processes of enzyme catalysis and membrane technology will lead to technical applications with a high degree of probability. Lactose hydrolysis to yield a mixture of glucose and galactose, which is more suitable for food applications than lactose, and classic primary conversions o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Molecular mechanisms involved in the IGF-1R signalling setting of the somatotropic axis'.

assistant: **Innovation**

This proposal aims to understand molecular mechanisms involved in the induction and persistence of the somatotropic function decrease observed in mice with diminished IGF-I signalling. This alteration could be induced by a specific heterozygous IGF-1R invalidation in mice brain, and in wild type mice, by a nutrient restriction during the first two weeks of life. Previous results obtained in these both models indicate that diminished IGF-I signalling first decreases hypothalamic GHRH gene expression in first 10 days of life, which alters development of somatotrophs cells in pituitary. Preliminary data indicate that this is not associated with a decrease of GHRH neurons number and suggest an alteration of gene transcription. Environmental programming of endocrine axis activity through gene transcription suggests implication of epigenetic mechanisms. Thus, using the two mice models cited above, I plan to study epigenetic modifications on the GHRH promoter (CpG methylation & histones modifications). GHRH gene expression requires Ikaros that has been shown to act through changes of chromatin access. If modifications of GHRH promoter were confirmed, I will determine Ikaros gene expression by real time PCR. Next, it could be interesting to study Ikaros promoter methylation profile, since it contain 1kb CpG island. The second part of this proposal will be on mechanism involved in the persistence of somatotropic axis decrease and will focus on somatotroph cells, which are a key element of this axis. The study the GH promoter methylation profile will indicate if the gene expression alteration is associated with epigenetic changes. In this case, a particular attention will be hold to its two essentials enhancers, Ikaros and Pit-1. High throughput pyrosequencing will be use to perf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Automated Improvement of Continuous User interfaces'.

assistant: **Concept**

We propose to develop two tools for creating, in a systematic way, better user interfaces based on continuous, non-symbolic actions, such as swipes on a touch screen, 3-D motions with a hand-held device, or breath patterns in a user interface for otherwise paralyzed patients. The tools are based on two experimental/computational techniques developed in the ABACUS project: iterated learning and social coordination.In iterated learning, sets of signals produced by one user are learned and reproduced by another user. The reproductions are then in turn learned by the next user. In the ABACUS project, it has been shown that this results in more learnable sets of signals. We propose to show how this can be applied to creating learnable and usable signals in a systematic way when design a user interface for a device that allows continuous actions.In social coordination, it has been shown that signals become simplified and more abstract when people communicate over an extended period of time. The ABACUS project has developed techniques to detect and quantify this. We propose to show how these can be used for a user interface that adapts to its user. This will allow novice users to use more extended and therefore more learnable versions of actions, while the system adapts when users become more adept at using the interface and reduce their actions. Because the system is adaptive, the user is not constrained in how they do this.Concretely, we propose to implement these two tools, investigate how they can be used optimally and advertise them tointerested companies, starting with ones with which we have contact, but extending our network at the start of the project through a business case development. In order to disseminate the results we propose to involve a user committee and or
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Methodology for optimisation of the making up for determination of cyclic and frequential" times to create a database"' in the context of a Fifth Framework call.

assistant: **Objectives**

One of the key factors to increase the competitiveness in the clothing industry into reduces the production costs. The aim of the project is, for each kind of work, to analyse each workstation (by operation type) to maximise their efficiency and reduce their production costs. This will be possible with a better utilisation of the equipment, accessories and materials, with the non-working times elimination, with a correct operators utilisation, reducing the non-necessary movements and displacement (80% of the sew operation time is passed doing manipulations and only 20% is sewing). After those analysis it will be possible to have the good method and time and keep that knowledge in a data base (times and pictures).A database with times and pictures is an easy and practice computerised tool to save know how and to have important information in real time. For each new model, it will be possible to make an operation plan very quickly, with very few new chronometers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Energy Performance, Indoor environment Quality, Retrofit : a cost predictive European retrofitting evaluation method for improving the energy performance and the indoor environment of existing apartment buildings' (EPIQR).

assistant: **Concept**

Objectives The main objective of this project is the development of an evaluation tool to assess retrofitting needs, and the costs and the planning of activities to meet these needs with respect to the optimisation of energy consumption, the use of renewable (solar) energy and the improvement of the indoor environment. The evaluation tool (called EPIQR method) will be a computer based multi-media programme applicable to existing apartment buildings to be used by architects and engineers and others at the outset of a potential project in order to help in decision making. Technical Approach The essence of the EPIQR project is the extension and application of the MERIP method developed in Switzerland to a wider field and to other countries in Europe. The MERIP method is a condition survey of the physical and functional state of a building and gives an evaluation of refurbishment costs. The method is based on 50 criteria or items on a category basis, from a) very good to d) very poor. Examples of the items e.g. roof, cladding, in the various states will be contained in pictures on a portable computer. Costings will be obtained from a statistical cost database. Decisions about refurbishment are difficult to make without cost estimates, but detailed costing is expensive and sually will not be undertaken until the decision in principle to refurbish has already been taken. The EPIQR method offers a way out of this impasse. New building where standards of energy conservation are now generally very high, represents only a very small and declining proportion of the housing stock, so more attention must be devoted to refurbishment. The benefits are considerable, for example up to 1 billion ECU in the UK and of the order of 6% of total domestic energy consumption as well as the wide