RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Human and animal metapneumovirus molecular and clinical studies for disease control' (HAMMOCS).

assistant: **Concept**

A newly discovered virus, human metapneumovirus (hMPV), responsible for respiratory disease in young children, is closely related to subgroup C isolates of the prototype metapneumovirus, avian pneumovirus (APV). APV is a major cause of significant economic losses in the poultry industry in Europe. Current diagnostic techniques cannot detect these metapneumoviruses and as a result the significance and distribution of hMPV subgroup C APV are not known. Thus the burden of disease from these agents cannot be assessed. The proposal addresses these problems by generating new, standardised, detection and characterisation assays, developed for commercial use. Using reverse genetics techniques for both hMPV and APV, the molecular biology, aspects of pathogenicity and host specificity will be analysed This will also generate recombinant viruses which will be the foundation for future rational vaccine design.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The feasibility of ceramic hollow fibre membranes and modules for beer and wine filtration' (1998-2002).

assistant: **Concept**

The main objective of the project is to set-up a pilot production line for the manufacturing of fully tested ceramic hollow fibre membrane systems for the filtration of beer and wine. Filtration by means of ceramic (micro filtration)membranes is expected to be a good substitute for current separation steps in beer and wine filtration. The project consists of the following steps:- Preliminary manufacturing and testing of ceramic hollow fibre membranes- Manufacturing and testing of small-scale membrane modules- Techno-economical evaluation and definition of production line- Setting-up of pilot production line for ceramic membrane and modules- Piloted plant set-up and testing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advanced training programme in bacterial cell biology and transcriptome analysis' (ATP-BCT).

assistant: **Innovation**

The increased resolution and sensitivity of the latest fluorescence microscopes, imaging equipment, and software, now makes it possible to follow specific proteins and processes in living bacterial cells. These developments have initiated a new and very successful discipline i.e. bacterial cell biology. Another recent and prolific technique that has become part of the molecular microbial toolbox is transcriptome analysis, in which DNA micro-arrays are used to measure genome-wide transcriptional regulation.This programme aims at providing first-class multidisciplinary training in molecular microbiology with the emphasis on cell biology and transcriptome analysis. The training programme is focussed on outstanding young researchers from EU countries/regions in which the equipment and expertise to do state-of-the-art bacterial cell biology and transcriptome analyses are not readily available. The programme comprises several long-term fellowships (PhD training) as well as a number of short-term training courses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Kidney Transplantation - Functional ImmunoGenomics'.

assistant: **Objectives**

Chronic renal failure affects ~10% of the world population and can gradually lead to end-stage renal disease (ESRD) requiring kidney transplantation. Despite the huge progress of immunosuppressive treatments, the host immune response against the graft still leads to rejection in many cases, with an average graft half-life of 10 years. Triggers leading to graft rejection are still largely unknown and need to be studied beyond the well-recognized impact of HLA mismatches.I propose here to explore the effect of functional immunogenomic parameters beyond HLA mismatches (HLA alleles, HLA gene expression regulation, KIR...) on kidney transplantation outcomes (cellular and humoral rejections, tolerance). To achieve this present-day clinical challenge, I will combine innovative bioinformatics tools and modern genomics to perform cutting edge association studies: the Kidney Transplantation - Functional ImmunoGenomics (KiT-FIG) project. KiT-FIG ultimate goal is to provide new evidence to improve graft allocation and transplanted patients’ management.Objective A is to develop innovative methods of HLA statistical inference to gain precision and generate additional functional immunogenomic parameters. Objective B is to apply these novel methods to investigate the impact of immunogenetics on immunological outcomes related to kidney transplantation. This objective will rely on genetic association studies to unlock the major scientific challenge of large and unexplained variability observed in renal graft survival.KiT-FIG ambitions to develop new innovative bioinformatic and biostatistics tools to capture the complexity of HLA-related immune responses. These tools will be freely accessible to the community to expand immunogenetic studies of other diseases. The implementation of these
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Strengthening the SOLid-state research capacities in Zagreb by the introduction of the Nuclear Magnetic Resonance method'.

assistant: **Concept**

The Physics Department of the Faculty of Science at the University of Zagreb (PDFS) is the leading university physics department in Croatia with 70 internationally recognized scientists and 660 undergraduate and graduate students. A considerable part of the research in PDFS is devoted to solid state physics and materials science. Given that nuclear magnetic resonance (NMR) is today an unavoidable method in solid-state physics, we aim this project at complementing the infrastructure for materials research at the PDFS by the introduction of a solid state NMR (ssNMR).  With this project, we shall accomplish four tasks: (a) strengthen the human potential in solid state research, (b) purchase and install an ssNMR spectrometer, (c) further develop a cooperation with European NMR centres of excellence, and (d) make the overall research capabilities of PDFS and especially ssNMR method visible to the wider scientific community, general public, and small and medium enterprises (SME) in Croatia and South Eastern Europe (SEE). Human potential will be strengthened by: (i) specialization of young researchers in high-quality European NMR laboratories, (ii) the return of experienced researchers from abroad, (iii) the exchange of know-how and experience by secondments of senior Croatian researchers and top European NMR researchers. The promotion of PDFS will be achieved by: (i) the organisation of two workshops with targeted audience of young researchers in SEE, (ii) the organisation of seminars for industry and SME managers about the possibilities of materials research at PDFS, (iii) active participation of Croatian researchers in EUROMAR conferences and European magnetic resonance societies, and (iv) the interaction with the public media. The new ssNMR group will reinforce the overall
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Suppression over a high dynamic range of ase at the rising edge of ultra-intense femtosecond pulses' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Objectives:The recent progresses in lasers with ultra-high-intensity pulses are now hindered by a strong limiting factor linked to imperfections in the pulse temporal profile. Innovative physics experiments at relativistic intensities that probe new domains such as particle acceleration or laser assisted nuclear physics are inaccessible due to the high level of amplified spontaneous Emission (ASE) pedestals and pre-pulses. The objectives of this program are to develop new techniques devoted to obtain temporal contrast suitable with interaction in a regime of intensity higher than 1020 W/cm2. Reduction of the ASE level with respect to the femtosecond pulse will be obtained by non-linear effects.Different ways will be investigated through this RTD program, corresponding with associated work packages: Moreover measurement techniques over high dynamic range will be improved. Non linear cleaning and filtering processes like non-linear cleaning by saturable absorber or non linear interferometer, second harmonic generation, or plasma mirrors will be studied. OPCPA techniques need to be fully characterized in term of contrast improvement, such as excimer amplification usable after seeding by frequency converted pulses. In the first 12 months of the project, partners have successfully designed, bought, built, and implemented: · New high order cross-correlators and UV correlators improving the measurement dynamics. (WP1 tasks 1.1, 1.3, 1.4) · New high energy, high contrast oscillators (WP2 task 2.1) · New schemes of non linear filtering at millijoule level (WP2 task 2.3) · Promising technique using plasma mirrors (WP2 task 2.4) · New designs of excimer amplification in XeF (WP3 task 3.1) · Measurements of ASE contrast properties in Optical Parametric Chirped Pulses Amplification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Circular migration and home care? The case of Romanian and Ukrainian home care workers in Northern Italy' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

In its recent documentation on migration issues, the European Commission has been promoting “circularity” as an effective and efficient way to manage labour migration from both within and outside the EU. But how does the employment of circular migrants exactly work and what are its implications for Europe's societal challenges such as ageing and immigration?To answer to these questions, the present study focuses on Eastern European circular migrants and the elderly care sector. In particular, it draws attention to Romanian and Ukrainian care workers within the two Italian provinces of Verona and Reggio Emilia with the aim to assess the actual convenience of “circularity” for the overall improvement of home care provision. On this ground, it pursues three interrelated research objectives: 1) the impact of “circularity” on the employment relationship between care workers and their employers; 2) the way circular migration affects the organisation of home care from the welfare state’s point of view; and finally 3) the conditions which allow “circularity” to take place in an efficient and profitable way.These issues are investigated in a comparative and diachronic way, looking at the differences between  Ukrainian and Romanian migratory patterns during the period of 2006-2011. A further layer of comparison is  added by the differences between Verona and Reggio Emilia, two towns with relevant dissimilarities concerning political traditions and public administrations.Finally, this project contributes to the scholarly debate on gender, care and migration by introducing “care units” (i.e. the ensemble of subjects involved in the provision of care to an individual care receiver) as an innovative object of analysis. In order to assess the impact of “circularity” on these “care uni
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'New Archaeological Research Network for Integrating Approaches to Ancient Material Studies' (NARNIA) under Seventh Framework.

assistant: **Objectives**

This project encourages the collaboration between the private and academic sectors for the training of young researchers in the integration of traditional archaeological approaches and newly developed scientific techniques to the study of ancient materials. This well- structured research network aims to improve the career prospects of employment for young researchers, developing their lab-based skills in the study of ancient materials, while contributing to the history and archaeology of the Eastern Mediterranean basin, a region of great historical, cultural and geo-political significance.In particular, through a comprehensive mobility scheme, young researchers will have the opportunity to continue their research careers at high profile universities and well-established private enterprises while working in research projects focused on the study of ancient material culture. Researchers will be appointed to integrate theory and archaeological sciences for the study of different material categories, including ceramics, metals, glass and mosaics from primarily Cyprus, Greece and Jordan. The proposed program engages experienced academic and research staff, young entrepreneurs, and young researchers for a broad collaboration network, which will facilitate the exploration of analytical equipment and research data, while concurrently directing and promoting research activities in Eastern Mediterranean countries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Design, Synthesis and Biological Evaluation of HIV-1 and HCV inhibitors'.

assistant: **Objectives**

In the proposed study we aim to investigate novel Human Immunodeficiency Virus (HIV) and Hepatitis-C (HCV) inhibitors that will improve the quality of life of the infected patients, reduce or avoid the toxic effects of the current treatment and ultimately assist in the eradication of these viruses. The current treatment for HIV that includes inhibitors of viral entry, protease and transcriptase activity, is compromised by the persistence of viral reservoirs, drug resistance and adverse side effects. HIV-1 integrase (IN), the enzyme responsible for integrating the viral DNA to the host genome, is essential for viral replication and represents an ideal target for drug design. The current treatment for HCV of interferon-α and ribavirin has demonstrated limited success in treating all genotypes and alternatives with improved efficacy represent an important unmet need. The HCV NS2-3 and NS3-4A proteases and the NS5B RNA dependent RNA polymerase are an essential component of the viral maturation and replication and are thus, ideal targets for the development of new anti-HCV inhibitors. In the course of this project, we will explore the design of novel inhibitors that will target the viral enzyme IN, the HCV NS2-3, NS3-4A proteases and the NS5B RNA dependent RNA polymerase. In our study we will introduce state-of-the-art technologies; we intend to employ a de novo computer-aided drug design method for designing novel inhibitors of IN, NS2-3, NS3-4A and NS5B viral proteins, design synthetic routes for their preparation and develop specific assays for the aforementioned viral proteins. The creation of new medicine necessitates efforts in multiple directions and requires collaborations between research institutes, here the University of Cyprus (UC, host institute) and the Scripps
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Quantification and modality in the realm of questions'.

assistant: **Objectives**

The interpretation of linguistic expressions has been investigated from various theoretical perspectives, ranging from linguistics and philosophy to logic and cognitive science, leading to many applications in computer science. At the heart of this enterprise is a simple yet powerful notion of meaning as truth-conditional content. Despite its merits, this view has a fundamental limitation: while suitable for statements, it does not apply to other sentence types, like questions.This limitation has recently led the applicant and his collaborators to propose a more general notion of meaning, giving rise to a new semantic framework called inquisitive semantics. This framework opens up new horizons for all disciplines concerned with linguistic meaning. The present project explores these horizons in logic and linguistics, also making substantial connections with philosophy and computer science.In linguistics, besides providing a framework for the analysis of questions, the new approach suggests that inquisitive content plays a role in the semantics of statements as well, which sheds new light on recent linguistic observations that are highly puzzling from a purely truth-conditional point of view.In logic, the enriched notion of meaning also opens up new, exciting possibilities. While logic is standardly concerned with reasoning processes that involve concrete pieces of information, our new perspective also allows us to consider reasoning processes involving types of information. Relations between types of information play a central role in natural sciences, and also in various applicative domains in computer science.The project will explore in detail how the inquisitive perspective extends the boundaries of logic and linguistics, with a particular focus on the domains of quan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Profiling NMDA receptor in schizophrenia and predicting clinical trajectories from rsEEG using dynamic causal modelling'.

assistant: **Innovation**

The richness of chemical signalling in the brain supports the flexible neural dynamics required for adaptive behaviour. The NMDA receptor, one of the most ubiquitous receptors in the brain, controls synaptic plasticity and mediates learning and memory formation. Its dysfunction is theorised to be one of the mechanisms of schizophrenia. Profiling the changes and dysfunctions of ion channel receptors can elucidate the biological substrate of functional brain impairments and facilitate individual patients’ personalised treatment strategies. The aims of this project are two-fold: methodological—developing a robust and translational dynamic causal model able to profile NMDA-R dynamics—and clinical—studying NMDA-R dysfunctions and their trajectory within a longitudinal study of a large cohort of schizophrenic patients. The NMDA-R DCM will first be developed and validated on animal data with a high signal-to-noise ratio. The ground-truth dataset comes from a repeated measures study, with one of the measurements involving a pharmacological intervention using an NMDA-R blocker. Next, the model will be translated to human rsEEG data with the same within-subject design. Finally, the validated NMDA-R DCM will be applied to schizophrenic patients. The prospective design of the study will allow for the assessment of the predictive power of generative embedding for individual patients’ clinical trajectories. This approach might help clinicians predict clinical outcomes and tailor treatments to individual patients. We plan to disseminate the project’s results through two main channels: peer-reviewed publications of both methodological and clinical advancements, and by sharing the relevant source code for the analyses, including the envisioned additions to the TAPAS package, thereby fos