RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The role of the leucocyte infiltrate in cancer, especially the interactions between tumour cells and macrophages' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The malignant tumours comprise a mixture of transformed cells, normal cells and extracellular matrix. The normal cells within a tumour, predominantly endothelial cells, fibroblasts, lymphocytes and macro-phages, contribute to tumour growth and progression. Tumour associated macrophages, TAM, are especially important in this regard. The aim of this project is to study interactions between TAM and tumour cells that may enhance tumour cell invasiveness, and other processes in tumours, such as angiogenesis. The researcher has obtained novel data suggesting that soluble signals that pass between human macrophages and tumour cells can enhance the invasive capacity of tumour cells in a process that involves matrix metalloproteases.The researcher obtained a competitive fellowship to visit the host laboratory from October 2002-January 2003. Using techniques and expertise of the host laboratory he demonstrated a role for the inflammatory cytokine tumour necrosis factor-alpha (TNF-a) in the interactions between TAM and tumour cells. The aim of the proposed project is two fold. First the researcher wishes to investigate the in vivo relevance of his observations using mouse cancer models and transgenic mice that are established in the host laboratory.Second, the researcher wishes to use state-of-the-art expression array facilities in the host Institute, in collaboration with proteomics facilities available in his home laboratory, to further investigate the mechanisms by which macrophages enhance tumour cell invasiveness .It is hoped that the data obtained from this fellowship application may lead to novel therapeutic and diagnostic/prognostic strategies in patients with invasive cancer, and establish a continuing collaboration between the host laboratory and Gottingen.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Extraction of parton distribution functions and fragmentation functions with uncertainties.' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content I intend to continue to center mv research Problems among Women in European Countries will examine the drinking patterns and problems of women in eight European countries. This will be done by comparing alcohol consumption and alcohol problem rates within and between countries and between men and women and among women. In addition, an important methodological component of the proposed concerted action is to make recommendations for much needed standardised measures of alcohol consumption and alcohol problems for use in European alcohol epidemiological research. The proposed project involves the collaboration of alcohol epidemiologists from eight European countries, the Czech Republic, Finland, Germany, Italy, the Netherlands, Scotland (United Kingdom), Sweden, and Switzerland, and will coordinate national efforts on an inter-European level so that trends and patterns within countries may be compared with others and thus may be more readily usable and accessible for European Union policy purposes. The proposed concerted action, "Alcohol Consumption and Alcohol Problems among Women in European Countries" has the following measurable objectives: (1) To standardise drinking measures. (la) With data sets on alcohol consumption which have already been collected by the partner countries, the first objective is to develop standardised units to compare alcohol consumption and alcohol problems across European countries. (lb) Recommendations for standard measures and approaches for future measurement of alcohol consumption and alcohol problems Europe-wide will be developed. (2) To investigate differences in drinking patterns within and between countrie This will be done looking at differences between men and women, and among women. (2a) With availab
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Data-driven Modelling in Dynamic Networks'.

assistant: **Innovation**

Dynamic models play a key role in many branches of science. In engineering they have a paramount role in model-based simulation, monitoring, control and optimization. The accuracy of the models is key to their subsequent use in model-based operations. With the growing spatial complexity of engineering systems, e.g., in power networks, transportation networks and industrial production systems, also referred to as cyber-physical systems of systems, there is a strong need for effective modelling tools for dynamic networks, being considered as interconnected dynamic systems, whose spatial topology may change over time. Data-driven modelling and statistical parameter estimation are established fields for estimating models of dynamical systems on the basis of measurement data from dedicated experiments. The currently available methods, however, are limited to relatively simple structures, as open-loop or closed-loop (controlled) system configurations.In this project I will make the fundamental step towards data-driven modelling (identification) methods for dynamic networks by developing a comprehensive theory with the target to identify local dynamical models as well as the interconnection structure of the network. I will incorporate the selection of sensing and excitation locations, data synchronization, and the optimal accuracy of estimated models in view of their use for distributed control. Solving these problems is by far beyond the current abilities of the existing identification frameworks in the systems and control community. My internationally recognized expertise in the field of system identification and model-based control, together with recent work on dynamic networks, warrants the feasibility of the project.Identification methods for dynamic networks will become
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Carrier for Cure: tailored combination drug delivery solutions for oncology' (CfC), addressing dissemination and exploitation.

assistant: **Impact**

Chemotherapy, often given in conjunction with other therapies is infamous for its off target associated side effects. Recent studies have shown that drugs combinations can act synergistically at certain ratios and are more effective and less toxic than single drug therapies. Despite promising in vitro results, combination drug therapy for Oncology has not been successfully translated to the clinic due to lack of efficient delivery systems that can maintain the desired synergistic drug concentrations in the body as each drug has a different pharmacokinetics and toxicity profile. The objective of this project is to develop a universal platform for simultaneous delivery of multiple drugs to specific cells in vivo using a protein cage that was developed in our laboratory for encapsulation of diverse cargoes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Support funding of an annual european maize organisations convention.' in the context of a Fifth Framework call.

assistant: **Objectives**

Annual meeting of research and development and technology transfer / advisory organisations within EU with primary interest in maize. The meeting to have a previously agreed theme for focusing papers. To share and exchange information and experiences currently acquired. To utilise the information for the benefit of members farming businesses. To identify common problems and find solutions and give direction to future research and development. To examine individual countries approach to technology transfer. To identify ideas for future EU research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Giving Rural Actors Novel data and re-Useable tools to Lead public Action in Rural areas' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Representing 30% of its population and over 80% of its territory, EU rural areas are facing simultaneous demographic, climate, economic, social and environmental changes which affect their characteristics and metabolisms. Responding to these challenges requires a precise understanding of what rural areas are and what rural communities are facing nowadays. Definitions of rural areas tend to lean on population density or size. They do not provide sufficient insights into the dynamics, drivers and fluidity of contemporary diverse rural-urban relations and identities that characterize ruralities across Europe. Despite the increasing acknowledgement that rural areas are diverse and that typologies should better reflect the identities of such territories, the lack of data at a fine scale prevents such innovations. Departing from an updated conceptualisation of rurality based on the multi-dimensional nature of contemporary rural-urban interrelations and interdependencies, GRANULAR will generate new insights for characterising rural diversity based on a multi-actor and interdisciplinary approach. Based on insights from Multi-Actor Labs, it will generate novel datasets using a wide range of methods and primary data, such as remote sensing, crowd-sourced data, mobile phone data and web-scraping. This data will then be combined with a variety of existing institutional data to derive indicators relevant to rural communities for the implementation of the Long-Term Vision for Rural Areas (LTVRA), so to measure resilience, well-being, quality of life and attractiveness. This will enable GRANULAR to create a Rural Compass, that take into account the factors affecting rural communities and their functional characteristics, informing policymakers and rural actors for the design of tailor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Analog SImulation and Variability Analysis for 14nm designs' to be submitted under Seventh Framework.

assistant: **Abstract**

In recent years the demand of the electronics industry on mathematical methods used in EDA  software has witnessed a tremendous growth. “The real world is analog and computers are digital.” These nine words set the stage for the great circuit design challenges of the next decade. To quote G. Dan Hutchenson, president of VLSI Research, “virtual reality is possible only with mixed-signal chips, and of course, every designer on the planet, from the creators of advanced smart phones to cars that nearly drive themselves, is hot on the trail of virtual reality.” Most current EDA methods and the tools that support them are inadequate to the task of designing for the “real world”, for to do so they must account for an enormous number of design considerations. The list is long and daunting for every application and includes process, voltage and temperature (PVT) variation, power consumption, process constraints and yield requirements. Advanced numerical techniques are imperative to address present-day challenges (going to 14 nm!) in the electronics industry.The motivation for this training network is the need for a network of highly educated European scientists in the field of mathematics for the EDA industry and computational science, so as to exchange and discuss current insights and ideas, and to lay groundwork for future collaborations. The challenge lies in the necessity of combining transferable techniques and skills such as mathematical analysis, sophisticated numerical methods and stochastic simulation methods with deep qualitative and quantitative understanding of mathematical models arising from problems in the electronics and EDA industry. The main training objective is to prepare, at the highest possible level, young researchers with a broad scope of scientific knowl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Improving dialogue between eu regulatory bodies and national metrology institutes'.

assistant: **Concept**

The project will improve the European regulatory infrastructure through enhanced dialogue between European regulatory bodies and national institutes on measurement aspects of regulation. There is an urgent need to improve mutual acceptance of compliance assessments to promote trade, innovation and the single market. A consortium of European metrology laboratories and the EU conformity assessment organization will work closely with national regulatory bodies and EU networks. The project will identify gaps in capability to be addressed through workshops, best practice studies and guidance on key issues such as uncertainty assessment, accreditation and training. The close involvement of regulatory bodies will ensure exploitation of the results that will be shared internationally through a parallel project supporting international trade agreements. Identification of weaknesses in the EU measurement infrastructure will help specify future research needs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Efficient algorithmic methods for preparing large resource states with neutral atoms', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The proposed research plan sets itself the main goal of preparing useful large resource states using quantum systems consisting of neutral atoms. These non-classical resource states are at the core of the full range of quantum technologies, from quantum metrology to quantum error-correction and communications. This main objective will be achieved through the synthesis of two novel techniques developed in distant research subfields, both under the umbrella of Quantum optics and information. On the one hand, we leverage the unique versatility of neutral atom systems, which has allowed these systems to emerge as a leading platform for realizing quantum technologies. On the other hand, we bring in the insights that were recently developed in the field of Quantum Algorithms, which has improved the asymptotic complexity of the most important fault-tolerant algorithms, including Hamiltonian simulation and search algorithms. The collection of these algorithmic insights are called Quantum Signal Processing (QSP). Our approach is novel from two perspectives. First, we will propose QSP as a method for controlling near-term quantum systems and preparing resource states, in contrast to its conventional application in implementing fault-tolerant quantum algorithms.  Second, we will develop techniques to make implementations of QSP-based state preparation and communication protocols feasible in near-term systems. The participant's expertise in quantum information and the host's expertise in atomic physics perfectly complement one another to render this ambitious objective possible.The proposed project is embracing an ambitious co-design approach, where the quantum software and the concrete hardware platform are developed in synchrony. The co-design approach is a requirement for develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Polymer Radicals as doublet emitters for Organic Light-Emitting Diodes' (PROLED), addressing dissemination and exploitation.

assistant: **Impact**

Stable neutral π-radicals can utilise up to 100% of excitons as doublet emission in organic light-emitting diodes (OLEDs), thus circumventing the limitations of traditional fluorescent (singlet) and phosphorescent (triplet) emitters. Our aim is to develop polymer radicals as a new class of highly luminescent emitters by chemically coupling stable radical molecules into suited polymer backbones. This will interconnect the benefits of low-cost solution-based processing of conjugated polymers and the attainable high efficiency of doublet emission from π-radicals. Novel polymers will be synthesized and scrutinized using a range of state-of-the-art spectroscopic techniques. The most promising polymers will be selected for OLEDs fabrication using solution-based methods. Polymer radicals exhibit simultaneously optical, electronic and magnetic properties. This will open new possibilities not only for OLEDs but also for other fields, such as photovoltaics, polymer magnetics, lightweight batteries and supercapacitors, spintronics and antistatic coatings for consumer electronics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Bringing INnovation to onGOing water management – A better future under climate change' (BINGO).

assistant: **Concept**

The water sector needs improved climate prediction and downscaling based on consistent grounds (IPCC 5th Assessment Report, 2013). There is also a need for near future weather scenarios and anticipation of their impacts in the water cycle together with risk management strategies. BINGO will provide demand-driven solutions for a number of specific climate-related challenges in particular for highly vulnerable water resources of strategic importance. Water managers and other stakeholders will then be provided with information on specific climate scenarios at the space/time resolution fitting their needs, enabling them to act at various geographical levels (local, regional and European). BINGO aims at reducing the uncertainty of climate predictions and developing response strategies to help society manage that uncertainty. An innovative approach consists of enrolling end-users from the start, identifying specific vulnerabilities, needs and concerns about future climate. BINGO is built around 7 research sites in Northern and Southern Europe, covering a representative range of climatic conditions as well as combinations of water systems and water pressures. They illustrate a variety of water cycles at local/regional scales in Europe over various timescales, as well as common problems, including floods and droughts; water quality pressured by CSO, agriculture and competing demands for water (urban/tourism; agriculture/food security; hydropower). To guarantee sound management strategies for future weather challenges, BINGO will develop and validate all solutions built by strong dynamic interaction of researchers with end-users and decision makers throughout the project. By creating such knowledge alliances, water managers and other stakeholders can share awareness of climate c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Cybergenetics: Theory and Design Tools for Biomolecular Control Systems' in the context of a Horizon 2020 call.

assistant: **Objectives**

We propose to develop a new theory and design tools for the estimation and real-time control of living cells. The control systems designed using these tools will precisely and robustly steer the dynamic behavior of living cells in real time to achieve desired objectives.  Cells would be controlled either collectively at the population level, or individually as single cells. The control systems achieving this regulation will be realized either on a digital computer that is interfaced with living cells, or using de novo genetic circuits that are introduced into the cells where they are designed to function as molecular control systems. Our methods will explicitly confront the numerous challenges brought about by the special environment of the cell including nonlinearity, stochasticity, cell-to-cell variability, metabolic burden, etc. The theory and methods developed in this project will thus enable the systematic, rational, and effective feedback control of living cells at the gene level, and will lay the foundation for a new corresponding body of knowledge which we call ``Cybergenetics''.  It will also open new research directions in the areas of control theory and estimation.We also propose to design three cybergenetic control systems, each addressing an important application in biotechnology or therapeutics. In the first, the controller will use light and nutrient supply to precisely regulate gene expression and cell growth in E. coli to achieve high protein and low biomass production rates. The second involves multiple feedback controllers regulating in parallel a large number of single stem cells, and leading to their differentiation to desired fates, e.g. beta cells, with potential for therapeutic applications. Finally, we will engineer into living cells dynamic mol