RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Functional impact of the psychiatric risk gene CACNA1C in human iPSC-derived microglia'.

assistant: **Innovation**

Psychiatric disorders such as major depression, bipolar disorder, schizophrenia, and autism are highly prevalent chronic diseases. However, their underlying pathophysiology is still largely unknown. Genomic studies have identified single nucleotide polymorphisms (SNPs) in the CACNA1C gene that are robustly associated with all of these major psychoses. Among these is the main non-coding risk SNP rs1006737. Beyond that, a gain-of-function mutation in CACNA1C has been described, which causes a multiorgan phenotype including severe cardiac arrhythmias, immune deficiency, cognitive abnormalities, and autism, named Timothy syndrome (TS). Immune alterations plus the involvement of their primary mediators in the brain, the microglia, have also been reported for psychiatric disorders. Based on this, we aim to introduce the risk A-allele of the CACNA1C SNP rs1006737 as well as the TS mutation G406R into human iPSC control lines using CRISPR base editing. The generated isogenic lines are then differentiated into iPSC-derived microglia cells (iMGs) and undergo a systematic functional characterization, including the analysis of transcriptomic profile, intracellular calcium levels, motility, phagocytic activity, cytokine release, cellular bioenergetics, and mitochondrial parameters. Furthermore, the newly created iMG cultures are tested in brain organoid systems to assess their effects on neuronal activity and function via multielectrode array recordings and single nuclei sequencing. The obtained results will contribute significantly to elucidating whether microglial function is causally affected by the selected CACNA1C risk variants, what underlying checkpoint mechanisms are involved, and whether these changes compromise microglia-neuron interactions, thereby impairing neuronal acti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'The Macroeconomic Effects of Corporate Tax Reforms' to be submitted under Horizon Europe.

assistant: **Abstract**

Taxes paid by companies are a key source of government revenue. Among OECD countries, corporate taxes in 2018 accounted for an average of 10% of total tax revenue, 3.1% of GDP, and 5.7% of gross business profits. Beyond their importance for fiscal revenue, corporate taxes have large economic effects through their impact on private investment, a key driver of short-run fluctuations and long-run growth. Moreover, recent developments revived the interest in corporate taxation, including the massive debts accumulated during the pandemic, the exhaustion of monetary policy, the secular increase in business profits, and tax competition.  I will develop and apply new structural frameworks to assess the macroeconomic impact of corporate tax reforms on business cycle fluctuations, capital misallocation, capital valuation. Relative to the literature, my investigation integrates important dimensions that have not been jointly examined before due to their complexity, including (1) the interaction of corporate taxes and empirically relevant investment frictions, (2) the richness of firm heterogeneity in the microdata, (3) the general equilibrium feedback and dynamic effects that differentiate short and the long-run responses, and (4) the relationship with monetary policy. I will apply methodological advances that I recently developed which overcome the technical challenges and allow me to contribute to the state-of-the-art by incorporating all of these dimensions into the analysis.Part I develops the theory to formalize how corporate taxes determine macroeconomic outcomes and conduct counterfactuals.  Part II combines the theory with cross-country data to provide systematic evidence on the impact of corporate tax reforms, organize the historical experience, and derive policy recommen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Roadmap for Conversational Interaction Technologies'.

assistant: **Objectives**

ROCKIT is a strategic roadmapping proposal for research and innovation in the area of natural conversational interaction. The primary scientific focus concerns interactive agents which are proactive, multimodal, social, and autonomous. A second focus concerns systems which can extract and exploit rich context and knowledge from heterogenous data sources.<br/>The main goal of ROCKIT is the development of a Research and Innovation Roadmap which integrates the vision and innovation agendas of those organisations (concerned with R&D and exploitation) in the field across Europe, with a broad coverage across sectors. A key goal is to bring together public sector research organisations with commercial organisations at all scales, with a particular focus on SMEs that represent the majority of fragmented commercial activity in Europe.<br/>ROCKIT has five key objectives:<br/>1. Construction of a unifying roadmap for natural spoken and multimodal interaction;<br/>2. Formation of a broad-based, cross-sector community mobilised around the ROCKIT roadmap, the Conversational Interaction Technology Innovation Alliance;<br/>3. Recommendations for a common European platform based on an open architecture for Conversational Interaction Technologies;<br/>4. Identification of a number of target scenarios to drive future research, innovation, and economic/social development;<br/>5. Establishment of a research and innovation agenda for Conversational Interaction Technologies.<br/>A key aspect of ROCKIT will be to organise a European research and innovation community in the area of conversational interaction technologies, integrating a wide-range of commercial organisations with application and use links to the area.  ROCKIT will be structured around a set of sector-based clusters including mob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Pilot scale demonstration of novel CO2 co-polymerisation catalysts in the PU polyol market'.

assistant: **Concept**

The European polymer industry is under increasing pressure to produce innovative products at lower cost to compete with overseas imports. Econic Technologies has invented a catalyst that enables replacing up to 40% of petrochemical feedstock in the production of polyurethane polyols, an important polymer segment, with low cost waste CO2, resulting in high performance product. Econic Technologies is spun out of Imperial College London, where the technology was invented, now grown to a family of patent-protected catalysts whose unique characteristic is high reactive activity and selectivity for polymers under low pressures. The catalysts enable the maximum theoretical uptake of CO2 with far superior reaction rates than their competitors under industry relevant conditions.The Econic catalyst creates novel value-add polyol building blocks for polyurethanes whilst offering significant feedstock savings: CO2 costs $100/Tonne whereas PO costs $1900/tonne. When competitive technologies require expensive new plant facilities to meet stringent process conditions Econic’s catalyst can be deployed by a low cost retrofit. The technology is proven in the lab (TRL6) and client-site demonstration (TRL7) has commenced on small scale. The Phase I feasibility study has established that early adopting market leading polyol producers are keen to deploy the technology but they still need to persuade their downstream customers, the polyurethane producers. This will crucially be assisted by demonstrator applications which Phase II will now develop. Over the first five years after Phase II completion, Econic generates EUR180m catalyst sale revenues. Polyol producers will benefit by increased profit margins to the tune of EUR380m over the same period. Catalyst toll manufacturers will generate tu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Origin and lineage specification of trophoblast cells in early human placenta' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

My central question: how does the human placenta develop and how are specialized trophoblast sub-types generated? Despite advances in placental biology, pregnancy disorders occur frequently with few treatment options available, resulting in considerable maternal and/or infant mortality and morbidity. The cause of these disorders is abnormal early placental development but ethically and practically this is hard to investigate. Developing in vitro models that are truly representative of normal first trimester trophoblast will allow investigation of lineage specification and differentiation. I will take an interdisciplinary approach to characterize the first trimester villous cytotrophoblast (VCT) population. Specifically, I aim to:1. Characterize the expression of trophoblast stem (TS) cell transcription factors and epigenetically regulated genes to identify the anatomical compartment(s) containing population(s) with stem cell characteristics2. Isolate VCT using a specific cell surface marker and perform an in-depth molecular characterization at a single cell level to identify putative TS cells3. Characterize cell signalling pathways in the VCT and in the putative TS cell population4. Establish cell culture conditions for TS cells5. Perform a detailed characterization of cells cultured in vitroThis proposal has arisen from preliminary results obtained working in Centre for Trophoblast Research, University of Cambridge. Working in a lab with extensive experience of trophoblast isolation (Prof. A.Moffett) and input from our collaborators, Dr. M.Hemberger and Prof. G.Burton who have experience in mouse TS cells and human placental function in vivo, respectively has been pivotal. I am thus in an ideal position to capitalize on this expertise together with other stem cell labs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EM compatibility ANALYsis  Statistical Techniques in aeronautics' (ANALYST) targeting Horizon 2020.

assistant: **Abstract**

The large density of cables transporting various signals due to the introduction of composite materials and the transition to a More Electrical Aircraft is nowadays increasing the complexity of the design from an EMC point of view. So that the evolution of regulations makes safety analysis mandatory for the EWIS, leading to the necessity to estimate the reliability of the wiring system together with the functions which are committed to it. New EMC EWIS design rules and prototyping tools are needed to ensure the required very low rate of failure, without assuming too high design margins which could question expected gains at “global platform” level, increasing weight, installation complexity and cost.ANALYST aims at developing and validating a numerical modelling methodology based on statistical approaches for the specific context of EM compatibility analysis of cable harnesses in aeronautics.The following main goals will be pursued:• Development of a statistical harness modelling methodology, suitable to catch real-life complexity of aircraft installed harness (of the order of 40.000 cables, 10.000 electrical links) • Demonstration, evaluation of effectiveness and validation of the methodology; different modelling approaches, referring to state of the art solutions and innovations will be compared and validated with respect to measurement data. • Integration of the finally selected modelling approach in a CAE Framework, already equipped with the workflows and procedures needed to properly manage the wiring complexity of real aircraft. The solution has been identified in a fundamentally original approach, assuming to definitely consider the not-deterministic nature of the above mentioned problem, looking for a statistical description and extreme value assessment of the r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SUstainable and REconfigurable ROBots for green manufacturing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Development of efficient, safe, green, and reconfigurable manufacturing systems requires seamless integration between software and hardware solutions, requiring cooperation between experts from different fields. The project aims to make advancements in green manufacturing systems through collaborative robots (CoBots), making them viable for SMEs. The field of robotics faces the challenge of a disconnect between experts from computer science that provide generic solutions and the end-users that work and interact with the hardware. By bridging this gap to enable the development of lightweight, efficient, and sustainable CoBots, SureROB will holistically train skilled researchers to contribute to European manufacturing. Through a well-balanced consortium of renowned academic bodies and industrial partners from seven countries, SureROB will develop and benchmark industrially feasible solutions. The focus would be not only to make the manufacturing process sustainable, but also address the sustainability of manufacturing CoBots themselves. Green tools and techniques will be developed. An important target would be achieving up to 20% reduction in the weight of the robot's components (drives and arms), resulting in lower energy consumption without compromising on the system reliability and robustness. Structural and geometric optimisation of the drives and arms will be investigated to improve the dynamic behaviour and efficiency with software-based design solutions. These will be supported with vibration control strategies working in sync with optimised path planning and condition monitoring strategies. Numerical and experimental evaluation of the developed solutions will be conducted for benchmarking them against the reference system. SureROB will address the cost and impact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Predictive model of seagrass growth and meadow spreads' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Seagrass meadows are among the richest and most productive ecosystems on earth. At present, theyare declining worldwide as a result of natural and human-induced disturbances. Numerous countrieshave adopted initiatives to protect and restore habitats domina ted by seagrass species. Successfulrestoration requires a detailed understanding of seagrass biology and integration of this knowledgeinto predictive models. The clonal nature of seagrass growth, by the regular addition of modules, hasallowed the simulatio n of seagrass clone spreading on the basis of their own growth rules and thepercentage of rhizome branching. However, construction of general predictive models for seagrasses,comparable to what has been accomplished in terrestrial plants, is still not poss ible. Therefore, themain objective of the present proposal is the construction of a spatially explicit predictive model ofseagrass growth and meadow spreading. We will assess how meadow growth and branching is relatedto the dynamic variables describing sho ot and rhizome growth, how these dynamic variables dependon the abiotic environment, and how the plants present in the meadow influence the most criticalabiotic variables. Thus, our studies will describe interactions between plants in a meadow primarilyvia the abiotic environment on the one hand, and via growth and branching parameters on the otherhand.In order to reach these objectives, we will adopt two complementary approaches: 1-monitoringbiological and abiotic variables along transects in natural meado ws and, 2- studying seagrassdevelopment and the resulting abiotic gradients under well-controlled conditions in mesocosms andflumes.Data derived from the foregoing studies will be used to implement the spatially explicit dynamicmodel. In the model, individ ua
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Mechanisms promoting the formation and migration of cruciform sister chromatid junctions during chromosome replication' to be submitted under Sixth Framework.

assistant: **Abstract**

Eukaryotic cells replicate their genome by firing multiple replicons throughout the S phase of the cell cycle. Origin firing is a highly controlled process and is coupled with the formation of specialized cruciform junctions. These structures have been con served throughout evolution and likely contribute to the establishment of sister chromatid cohesion during S phase and to assist sister chromatid-mediated replication and recombination processes. Under pathological situations these sister chromatid junctions (SCJs) represent a source of DNA damage as they can be converted into reversed forks in the absence of a functional checkpoint or into recombination structures in cells defective in RecQ helicases. SCJs form at an early step of DNA synthesis and chase replication forks although the mechanims leading to their formation and migration remain elusive. M. Foiani and collaborators have extensively characterized the SCJs that form during replication in budding yeast both under physiological and pathological situation. The aim of the present proposal is to understand at the mechanistic level how these structures form during initiation of DNA synthesis and how they move through the replicon chasing replication forks.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SUstainable PREdictive Maintenance for manufacturing Equipment' (SUPREME).

assistant: **Innovation**

Productivity improvements have major impact on EU economy and competitiveness. Industrial maintenance contributes largely to this competitiveness through reliability and availability of production equipments. The EU market of industrial maintenance can be estimated at 32 Bn€/year, in which outsourced maintenance represents 1/3. In continuous production industries (energy, chemical, food, cement or paper sectors) the ratio “maintenance costs/added value product” is even higher than 25%. In these industries, default component or process failure stop the whole production, therefore predictive maintenance is a critical issue.The objectives of SUPREME are- to develop and use most advanced signal and data processing dedicated to predictive maintenance and energy consumption reduction- to implement these tools in an industrial demonstrator- to develop, exploit and diffuse new tools for predictive maintenanceSUPREME’s main challenging results will be:-Innovative reference models for residual life prediction and optimal predictive maintenance of deteriorating system-Embedded advanced signal acquisition and features extractions for varying operating conditions machines-Real time data fusion (vibrations, acoustic emission, motor current, torque,…)-Off line data mining and self learning failure mode pattern-Automated loop for monitoring optimal machine stabilization-Dynamically updated condition monitoring software module-Specific dissemination toolsThe project impact will be the proof of predictive maintenance efficiency, reduction of down-time and energy consumption in manufacturing industry, demonstrated in a coated paper mill.To reach excellence on predictive maintenance, SUPREME consortium integrates key technical players on the maintenance added value chain, gathering technol