RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Creating leverage to enhance biodiversity outcomes of global biomass trade' (CLEVER).

assistant: **Concept**

CLEVER identifies new leverage points for sustainable transformation informed by a novel holistic approach to quantify biodiversity and other impacts of trade in major raw and processed non-food biomass value chains. In line with Pillars 3 & 4 of the EU Biodiversity Strategy 2030, we address all outcomes of this topic by adopting perspectives at the system and value chain levels. At the system level, we improve our understanding of leakage effects in the non-food biomass trade system informed by quasi-experimental evaluation techniques, quantitative scenario modelling, and policy case studies. At the value chain level, CLEVER engages with key stakeholders (i.e., producers, traders, retailers, civil society, and policy makers) in R&I co-design to identify leverage points for transformative change at corporate and institutional levels. Value chain analyses will produce ‘ecological footprints’ from advanced life cycle analyses and enhance our understanding of actor-specific behavior focusing on trade in soy, timber, wood pulp, and fishmeal/oil between Europe, South America, and Central Africa. Further CLEVER products and tools to influence decision-making at the right level include (1) improved indicators of biodiversity loss to inform business and policy, (2) enhanced features for the global modelling platform GLOBIOM to quantify trade-mediated leakage and SDG interdependencies in biomass value chains, and (3) an innovation action pool to support public and private decision-makers in choosing governance instruments that effectively enhance biodiversity and promote climate change mitigation and adaptation. Building on prior and ongoing engagement of its members at the science-policy interface and through partnerships with other projects under the destination on biodiversit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Modification of Molecular structure Under Strong Coupling to confined Light modES' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Understanding and controlling the properties of matter is one of the overarching goals of modern science. A powerful way to achieve is this by using light, usually in the form of intense laser beams. However, modern advances in nanophotonics allow us to confine light modes so strongly that their effect on matter is felt even when no external fields are present. In this regime of “strong coupling” or “vacuum Rabi splitting”, the fundamental excitations of the coupled system are hybrid light-matter states which combine the properties of both constituents, so-called polaritons. Little attention has been paid to the fact that strong coupling can also affect internal structure, such as nuclear motion in molecules. First experimental indications for this effect have been found, but current theory cannot explain or predict such changes. We will thus develop theoretical methods that can treat the modification of molecular structure under strong coupling to confined light modes. This will require advances in the microscopic description of the molecules under strong coupling by explicitly including their rovibrational degrees of freedom, as well as techniques to incorporate the influence of these modes in the macroscopic setting of collective strong coupling. In order to achieve this, we will adapt well-known techniques from quantum chemistry and combine them with the concepts of polariton physics. We will investigate what level of control can be gained through this approach, and whether confined light modes could act as a “photonic catalyst” to control molecular dynamics without requiring an active ingredient. This could present a novel tool to control photochemical reactions that are of paramount importance in the biological mechanisms of vision and photosynthesis, and hold gre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'COMPOSITE PHENOTYPIC TRIGGERS FOR BONE AND CARTILAGE REPAIR'.

assistant: **Objectives**

Osteoarthritis (OA) and osteoporosis (OP) are disabling, degenerative bone diseases with significant economic and societal impacts. The incidence of these conditions increases with age but in recent years the number of younger patients has increased, due mainly to factors related to modern life-styles. The efficiency of current pharmacologic and implant-based solutions are limited and often poorly tolerated. OPHIS aims to develop new, engineered biomaterials for the regeneration of both the osteo-chondral region and the vertebral body degenerated by OA and OP. These devices will be based on the unique combination of biological triggers in the form of (i) nanostructured biomaterials able to mimic the extracellular matrices of either bone or cartilage (ii) chemical and biochemical cues able to direct, control and preserve the phenotypes of the relevant cells in their respective histological compartments. OPHIS will explore the frontiers of knowledge of the effect of nano-structures on tissue regeneration and lead to the de-novo design of active structures able to trigger this process. User friendly and highly performing tissue substitutes will be developed as both acellular and cellular matrices for the regeneration of specific anatomical regions compromised by OA and OP. Focus will also be given to the study of the interactions occurring at nano-scale level between the implanted materials and the natural tissues. This information will complement the body of data obtained through clinically reflective in vitro and in vivo models. Dissemination will be integrated step-wise with the strategy for intellectual property protection and exploitation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'eVV - endoVascularVision: new endoscopic tools for real time vascular assisted vision' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

One of the main goals in endoscopic surgery is to improve reproducibility and safety by means of computer assisted systems to improve the surgeon’s vision. The main objective of this Transfer of Knowledge action is to conduct a common research programme leading to the development of new endoscopic assisted vision tools for real time enhanced identification of blood vessels (vascular vision). To this end, an intersectorial research programme is proposed, in which we will combine knowledge and expertise from two biomedical research groups with a company with high-level technological know-how in photonics. The project will structure the necessary transfer of knowledge to make possible the research needed to achieve the goals of the project. The medical groups will contribute with a high expertise in research models of endoscopic surgery, know-how in digital analysis of medical images, and a huge clinical workload allowing to test and refine the clinical solutions proposed. These will be combined with advanced technical support and the technologies recently developed within the biomedical company, to bring proof of principle models to real clinical tools. A common space for intersectorial research will be created. The programme involves an intensive component of bidirectional secondments of existing researchers together with new recruitments of experienced researchers to reinforce our skills in specific fields. The development of the technological solutions proposed will represent a major breakthrough in endoscopic imaging, with clear benefits to medicine and health technology. The solutions developed would find immediate applications in medicine, and the company is firmly interested in bringing innovations into current clinical devices. The proposed research would represen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Multiple Systems of Spatial Memory: Their role in Reasoning and Action' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The goal of the proposed project is to examine how the locations of the objects that constitute our environments are represented in memory and how such memories are used to support our actions in space. During the last three decades of research this topic has received a lot of attention by scientists from many disciplines, and over the years a number of theories have been formulated. However, our understanding of the nature and functioning of spatial memory still continues to change. More importantly, there exist empirical findings from two concentrations of research within spatial cognition that seem conflicting at first glance. On one hand, studies examining the organizational structure of spatial memory have shown that memories are encoded using allocentric reference frames; that is reference frames that encode the spatial relations among the objects of an environment. On the other hand, studies focusing on how people stay oriented towards their surroundings during locomotion suggest that egocentric representations (i.e., representations coding self-to-object relations) are involved. Recent models of spatial cognition have attempted to reconcile these findings by proposing multiple systems for spatial memory. In this project we will carry our a series of experiments in an attempt to gather empirical data to test the predictions of various theoretical models including a biologically-plausible two-system account of spatial memory that we have recently proposed (Avraamides & Kelly, in press). Drawing heavily from the literature on Stimulus-Response compatibility, this account combines the use of egocentric and allocentric representations to account for a wealth of data from all areas of spatial cognition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Impact of Reactive Oxygen Species produced by their sand fly vector on Leishmania sexual hybrid formation'.

assistant: **Objectives**

By transmitting hundreds of pathogens causing important human mortality and morbidity, vector insects are a major public health threat. Even if intrinsic insect parameters such as immune response are known to impact their vectorial capacities, the vector/pathogen interaction is still little understood. Phlebotomine sand flies are responsible for the transmission of Leishmania parasites, causing Leishmaniasis. This disease produces a wide spectrum of symptoms, due to a high genetic diversity of parasite strains. In addition to their clonal reproduction, Leishmania can engage in a cryptic sexual cycle resulting in hybrid progeny. Sexual mating is believed to be a major source of Leishmania genetic diversity, which drives changes in tissue tropism, pathology and drug resistance. Experimental generation of hybrids, until recently confined to parasites growing in the sand fly gut, is now possible to achieve in vitro. However, despite the possibility to culture high quantities of parasites, the frequency of hybrids generated in vivo is much higher than in vitro, showing that the vector gut environment is particularly adapted for Leishmania sexual mating. The mechanisms of Leishmania sexual reproduction and the parameters rendering the vector’s gut favorable to this process are currently unknown. I recently observed that pre-exposing parental parasite cultures to Reactive Oxygen Species (ROS) leads to an increased hybrid production in vitro, which led me to hypothesize that ROS, present in large amount in the sand fly gut, could be one of these parameters. Using a dual genetic approach applied on both the parasite and the vector, I aim to decipher the impact of the ROS produced by the sand fly gut cells on the engagement of Leishmania parasites in a sexual reproduction path. T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'From Silicosis to Chronic Respiratory diseases: an approach via epidemiological history (in France, Europe, Southern Africa, from the 1900s until today)' (SILICOSIS).

assistant: **Concept**

Silicosis, a pathology caused by the inhalation of crystalline silica dust, is the deadly occupational disease in history. Contrary to what some may think, it does not belong to a remote past as it struck massively in the 20th century and is still present in industrial societies, and is growing in emerging countries. SILICOSIS seeks to re-evaluate the epidemiological importance of silicosis by combining history, social science and public health. Indeed, its medical definition was literally, and minimally, bargained in the 1930s by employers and unions and States under the aegis of International Labour Organization. This truncated basis has continued to have its effects and led to a massive underreporting of the cases of silicosis, many of which were declared as tuberculosis. In this view, SILICOSIS will aim, first, at a rereading of the 20th century epidemiology of silicosis and tuberculosis from a transnational perspective by comparing European and Southern African mining fields, two regions particularly hit. It will also aim at analysing the real magnitude of silicosis today, mainly in the non mining sector, by questioning contemporary medical classifications. By combining history and social science with scientific knowledge drawn from pneumology, SILICOSIS will show to what extent a series of other chronic inflammatory diseases (sarcoidosis, rheumatoid arthritis and some others) is likely to be caused by the inhalation of silica dust. Last but not least, SILICOSIS hopes to contribute to a better prevention and awareness of dangers of inhalation of silica dust outside the mining sector. In order to fulfil these objectives, SILICOSIS will propose an innovative approach through the combined methods of history, medicine and quantitative social science on the basis of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Hand-held broadband hybrid graphene-quantum dots spectrometer' (SPECTRODOT) under Horizon 2020.

assistant: **Objectives**

Optical Spectrometry is a powerful non-destructive, high throughput technique used extensively for threat and hazardous substance detection, food inspection, process and environmental monitoring and quality control amongst others. The market is fragmented into many niche markets, mainly due to the different wavelengths ranges of interest. Hybrid graphene-quantum dot photodetectors can enable versatile spectrometer covering the whole spectral range from UV to mid-IR. The main goal of SPECTRODOT is to develop a prototype low-cost, hand-held spectrometer with broadband range from 400 to 2500 nanometres.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Proxies from cave deposits: testing their sensitivity using the current period of global change' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Speleothems are one of the better archives in the geological record to study low frequency paleoclimate changes at a high time resolution. Chronologies are well established via U-series radiometric dating or annual lamina counting. The information in speleothem records is provided by proxies, mainly geochemical, morphological and petrological properties of the sample analysed along its growth axis. However, proxy interpretation in terms of climate is complicated and needs calibration with monitoring studies, with pioneer studies that monitored cave climate and associated speleothems first done for the last two decades. However, both the cave environment and speleothems properties are expected to have changed since these early works due to the recent period of global climate change. So, the aim of this project is to evaluate if the present global warming and its associated climate effects are being recorded in cave environments and speleothems. Several caves from Europe where previous studies on cave environmental conditions and laminated speleothems have been undertaken are going to be revisited to analyse the changes in cave conditions since the earlier work. Laminated speleothems will be recovered from the same locations where previous samples were taken to study changes in the proxy record in the last decade(s). Speleothem climate proxies will be compared to changes in cave environmental conditions, and both the speleothem proxy data and cave climate conditions will be compared with known climate change as recorded in instrumental data from the nearest meteorological stations. The study will take special care in determining the response time of cave environments to changes in surface climate, and how fast these are transmitted to the speleothems. The noise contained
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Understanding long-range transcriptional regulation in the context of the 3D genome organization' (3DQuant).

assistant: **Concept**

Enhancers are regulatory elements that control the spatial and temporal expression of genes in metazoans. Enhancers are able to modulate transcription of a target gene from large genomic distances, as a result of the formation of chromatin loops that bring them in close spatial proximity to cognate promoters. The manner how specific patterns of enhancer-promoter physical interactions are established is linked to how chromosomes are folded in the three-dimensional (3D) space. Recent studies based on chromosome conformation capture (3C) have shown that mammalian chromosomes are partitioned into self-associating sub-megabase domains called Topologically Associating Domains (TADs). Genetic evidence suggests that 3D chromatin organization within and across TADs contributes to the establishment and partitioning of enhancers-promoters physical communication. Yet it is still unknown by which biophysical mechanisms chromosome architecture modulates enhancer action, and thus transcription. The goal of this proposal is to determine the quantitative relationship between 3D chromatin architecture and enhancer-promoter activity to unravel the mechanism of long-range transcriptional modulation mediated by enhancers. Addressing this goal requires a system where transcriptional outputs can be measured precisely and quantitatively, and correlated with 3D distances. To this aim, we will use state-of-the art genome engineering techniques to generate mouse embryonic stem cells with engineered enhancer-promoter pairs in an isolated chromatin environment, where a selected enhancer can be mobilized at different distances from its cognate promoter. We will use this system to quantitatively assess how 3D chromatin structure influences enhancer action by measuring transcription and promoter-enhan
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Electrophile-Mediated Three-Component Enantiospecific Cross-Couplings' under Horizon 2020.

assistant: **Concept**

One of the most challenging aspects of Suzuki-Miyaura reactions is the stereospecific cross-coupling of sp3 substituted boronic esters with aryl halides. Recently, the host group developed a metal-free, stereospecific cross-coupling reaction of chiral alkyl boronates with electron-rich aromatics, promoted by the use of electrophilic oxidants. This proposal seeks to substantially extend this cross-coupling chemistry through the application of a range of different electrophiles that will not only mediate the cross-coupling process, but also remain in the final product, creating multiple carbon–carbon bonds stereospecifically. In particular, the application of electrophilic organometallic species will be investigated so as to take advantage of the power of metal catalysts in the formation of carbon–carbon bonds. Through the use of this strategy, doubly functionalised enantiopure aromatic compounds may be formed in a very efficient three-component coupling process that utilises readily accessible enantiopure alkyl boronic esters, electron-rich aromatics and catalytically generated organometallic electrophiles.