RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Peptide-mediated signalling in plant disease resistance' (2002-2006).

assistant: **Concept**

Plants use complex recognition and response mechanisms to protect themselves from pathogen attack.Major resistance (R) genes specify recognition of pathogens carrying the corresponding avirulence genes leading to the rapid activation of a battery of inducible defences that is often accompanied by the collapse of challenged plant cells in the hypersensitive response (HR), which results in a restricted lesion clearly delimited from surrounding healthy tissue.In addition, immunity to subsequent attack by a b road range of normally virulent pathogens, so-called systemic acquired resistance (SAR), develops throughout the plant. CDR1 that encode an apoplastic aspartic protease, mediates a peptide signal system involved in the activation of inducible resistance mechanisms.CDR1 overexpression causes dwarfing and resistance to virulent Pseudomonas syringae. Antisense CDR1 plants were compromised for resistance to avirulent P. syringae and more susceptible to virulent strains than wild type. Little is known about peptide signalling in plants although this mechanism is a regulatory paradigm in animals.Genetics and biochemical dissection of the CDR1-mediated peptide signal in the model plant Arabidopsis should have an impact well beyond the disease resistance area. The aim of this proposal is determine the nature of the peptide signal generated by CDR1 action. Proteomic techniques or expression of epitope-tagged active site mutants will be used to direct identification of candidate peptides.In addition, phenotypic analysis of CDR1 over-expression and antisense lines crossed with other key signal mutants will help to establish how CDR1 is integrated within the disease resistance signal network and the physiological properties of the peptide signal system.The project will strengthen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Accurate EEG source localisation using patient tailored head models'.

assistant: **Objectives**

EEG records electric potential differences from electrodes attached to the human skin. Although multi-channel EEG can be used to localize its underlying sources, clinical application of this technique in, e.g. epilepsy and stroke monitoring, requires long preparation time to acquire electrode position and head shape and is also hampered by the poor knowledge of in vivo skull conductivity.In the ERC advanced project associated to this PoC proposal a large longitudinal EEG study is performed in stroke patients, which inspired us to find a method for deriving a tailored EEG-head model without the above inconveniences. The tailored EEG-head model will require only a limited recording time. This will enable us to accurately calculate the active brain areas also in patients which can only participate for a short time in experiments. It will be an important step to use high density EEG technology for clinical applications.We foresee that the prototype delivered by the end of the project can be developed into a commercial accessory EEG device that can be provided to end users for relatively small add-on price.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Production-Ready Oriented Development of Radically Innovative Vehicle Electric drive' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Opportunities to make electric vehicles radically energy and cost-efficient are rare. PRODRIVE is a response to the commercial potential created by environmental and political challenges recognized by all major world economies. PRODRIVE will address these global challenges through a completely new, mass-production-ready in-wheel electric motor for electric passenger cars. The project is customer-focused and is solving key needs of automotive OEMs who are only looking for already industrialized in-wheel motor solutions for their new vehicle concepts. This innovative product will displace current technologies with a reduction in vehicle manufacturing cost and its sales price, disrupting the existing market.1500 in-wheel motor is based on Elaphe’s patented unique electromagnetic and mechanical design, fits into 19’’ or larger rims, incorporates original OEM brakes, offers unprecedented peak torque and is essential to covering the torque needs of the upper-segment car market. PRODRIVE will result in an industrialized and mass-produced solution that will increase the energy efficiency of the e-powertrain by 10-15% when compared to current electric cars and offer 20 % more performance at 2% better efficiency than the closest in-wheel motor competitor. With the lowest production price, it is suitable for market entry even at lower production quantities. Being so disruptive, it will have faster penetration and higher degree of environmental and economic impact on established markets.Compared to today’s EVs, the end-user will experience lower car prices and an annual ownership cost reduction without sacrificing performance or comfort. PRODRIVE will bring Elaphe to Tier 1 supplier position at prominent automotive OEMs and enable 296 new employments, 200 million € in revenue with
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dissecting folding pathways of highly homologous, ultra-fast folding proteins' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The protein-folding problem, that is the question of how an unfolded polypeptide chain folds spontaneously into its unique three-dimensional structure, continues to be one of the central issues in molecular biology.With the discovery that many pathologica l conditions result from protein unfolding, misfolding and aggregation the protein folding problem has become relevant at a global level.Although nowadays mechanisms of protein folding can be elucidated at great detail using an array of experimental and theoretical approaches, a central question still remains elusive: how does the protein sequence dictate a particular folding scenario, modulating energetic and dynamic properties of the protein for functional purpose?The proposed project aims at providing an answer to this question by dissecting the folding pathways of two small and ultra-fast folding proteins, having high sequence and structural homology, by using a broad array of modern experimental techniques.The applicant stepped into the research area of protein folding only recently by developing a world-wide unique single-molecule fluorescence related method for monitoring ultra-fast folding dynamics of mini-proteins.Research training in the host institution, within the scope of the proposed project , will provide the applicant with a broad methodological and theoretical competency diversification in protein folding with emphasis on ultra-fast folding studies. The action will allow the applicant to integrate his own developments into cutting-edge protein folding research and to resume his career within the European Research Area.The fellowship will initiate an Intra-European collaboration between the applicant and the host institution, pushing forward synergies between the disciplines single-molecule fluorescence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Corporate Ontology Modelling and Management System' in the context of a Fifth Framework call.

assistant: **Objectives**

The ONTO-LOGGING project brings together the expertise of three industrial companies in the areas of knowledge management systems, intelligent agents, and user interface; two research organisations in the areas of ontology formalisation and user modelling to build a set of tools on which to base the next generation distributed knowledge management systems.This objective is to be achieved along four main lines of action:1) Developing of a distributed ontology formalization system, built over the existing W3C standards and Semantic Web activity, like RDF, RDF-Schema, or upcoming standards like OIL and DAML.2) Enhancing the customisation possibilities of current KM products, via a meta-repository of corporate knowledge which will allow to reduce start-up costs, and will make it possible for the user to dynamically optimise the corporate ontology as the knowledge of the organisation evolves.3) Developing and incorporating metrics which allow to quantify the relative success and merit of competing ontologies.4) Incorporating recent developments in intelligent agent technology for user modelling and intelligent category extraction.Objectives:The project objectives are:1. To develop a set of tools to pave the way for next generation distributed Knowledge Management systems, able to support different independent ontologies and knowledge bases and providing the basis for transparent interoperability and knowledge exchange.2. To integrate those tools into a KM platform which will be tested in a pilot site, in order to assess the benefits of deploying the ONTO-LOGGING technologies.3. To provide input for existing standardisation efforts in the area of corporate ontologies, and particularly in the area of ontology interoperability.The ultimate goal of the system is to build an Ente
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Application of Lithiated Carbamates to the Asymmetric Synthesis of Sulfolipid-I' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Mycobacterium tuberculosis, the causative agent of human tuberculosis, is unique among bacterial pathogens. Sulfolipid-I (SL-I) is the major constituent metabolite of thick cell wall present in Mycobacterium Tuberculosis (M-TB). SL-I comprises of a disaccharide and four chiral hydrophobic lipid substituents, the overall structure of which is responsible for the resistance of M. Tuberculosis to antibiotics. While SL-I has been shown to elicit specific responses from immune cells, the mechanistic basis of these effects, biosynthesis and biological activities are unknown. Although a number of studies have been reported on the synthesis of disaccharide core and hydrophobic lipids of SL-I, major challenges reside in the synthesis of chiral hydrophobic lipids, which comprise multiple stereocenters. It is aimed to synthesis the enantiopure sulfolipid-I in a short synthesis by utilizing the recent methodology developed by the Aggarwal group involving the reactions of chiral lithiated carbamates with boronic esters. This new strategy is a potentially powerful tool for the iterative asymmetric synthesis of complex molecules in short order.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ASSESMENT OF RESEARCH POTENTIAL OF AEGEAN AGRICULTURAL RESEARCH INSTITUTE' (ARPAARI).

assistant: **Innovation**

Increased sustainability is an important point to be taken into account while planning the agricultural research and then the capacity need to be evaluated and improved. Aegean Agricultural Research Institute (AARI) of General Directorate of Agricultural Research is one of the important research institutes for Central, South West Asia and North Africa region as partner on plant diversity conservation and sustainable utilization with over sixty thousand samples at its National Gene Bank. AARI is the coordinating centre for plant genetic resources and diversity program and member of European Cooperative Program for Plant Genetic Resources, European Plant Genetic Resources Search Catalogue  and Steering Committee of European Gene bank Integration System. Its mandate is conservation of plant diversity in Turkey, improvement of high-yielding, high quality, and disease  resistant cultivars; cattle and beekeeping studies; production of breeder seed of registered cultivars, dissemination and integration of research findings in agriculture. AARI would like to better serve for regional, national and international bases and to have physical and structural sustainability. However, there are some constraints that limit optimal research output that would be benefit for not only for Turkey but also for European Countries and adjusted region. The objectives of this proposal are to evaluate the research quality, capability, and describe the strengths, weaknesses, opportunities, threats of the research potential of AARI by SWOT analysis to improve the research capacity of AARI for better meet with ERA, integrate to the framework programmes with cooperative RTD proposals as one of the well organized partner centres on agricultural research programs for food quality and safety, and environ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Molecular Imprinting mediated regulation of cell behavior and related biomedical applications' (MIP4CELL) under Horizon 2020.

assistant: **Objectives**

Tissue engineering or regenerative medicine, with its ultimate aim of developing true human replacement parts, has recently made enormous progress. The field refers to the use of human cells to replace or regenerate tissues or organs. Ideally, biomaterials for tissue engineering should efficiently mimic functionalities of the natural extracellular matrix (ECM). Hence surfaces of biomaterials should be engineered for dynamic control of cell behaviour. The objective of this proposal is to exploit molecular imprinting as a dynamic methodology for biofunctionalization and tissue engineering. Building on our previous proof of concept demonstration of systems for cell sheet harvesting, we expect to hereby obtain dynamic biofunctionalization of surfaces and overcome limitations of currently used methodologies (e.g. ligand leaching in non-covalent approach, loss of bioactivity in covalent approach, and lack of means for dynamic control of cells adhesion in both). The specific objectives of the proposal are as follows:1) To establish bioimprinted hydrogels with thermo-responsive affinity to bioactive cell adhesive peptide as a generic platform for dynamically regulating cell adhesion and migration.2) To develop thermo-responsive DNA aptamer imprinted hydrogels for dynamic recognition of specific cells via cell-aptamer interactions, and using as a platform for capture and release tumor cells. Therefore, this proposal will mimic the in vivo dynamic characters of the ECM and allow to obtain controllable cell behaviours in artificial biomaterials, thus having potential applications in medical diagnostic and regenerative medicine.Bringing together a highly talented and creative experienced researcher, who has already contributed decisively to the field, with a leading research group
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'European geothermal project for the construction of a scientific pilot plant based on an Enhanced Geothermal System (EGS PILOT PLANT)', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

The present phase of the integrated European geothermal project at Soultz-sous-Forets (Alsace, France), which is managed by an industrial consortium, has demonstrated that an Enhanced Geothermal System (EGS) based on three 5000 m deep wells and using improved drilling, stimulation and diagnostic methods can be used successfully to access the geothermal energy at depth. This enhanced geothermal technology can be applied over wide areas of Europe under which naturally fractured hot rock mass exists.After a brief period of further testing, the proposed three year continuation program (i.e. 2004-2007) aims to install and operate a 1.5 MWe power plant, enabling the deep reservoir / heat exchanger created during the period 2001-2003 to be operated, evaluated and improved (if required) under realistic conditions. Both its thermal and hydraulic behaviour will be characterized over the short, medium and long term in conjunction with teams from other EGS sites; a general methodology of evaluating and developing EGS systems will be elaborated. Given positive results from the medium term tests, the power conversion unit will be increased to some 5-6 MWe at circulation rates of 80-100 l/s and a temperature of 190°C. In parallel with the hydraulic evaluation further characterization, evaluation and adaptation will be carried out on scaling and corrosion aspects, high temperature production pumps, surface heat exchangers, power conversion cycles and general reservoir management.The pilot plant will be used to test the in-site performances of the selected equipment in order to establish preferences for technical and economical gains for future larger industrial EGS installations (25 MW el. and larger) based on a multi-well approach.After successful operation, the pilot plant itself wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Collectiveware: Highly-parallel algorithms for collective intelligence'.

assistant: **Innovation**

In recent years, more and more scenarios pose challenges that require collective intelligence solutions based on networks (knowledge networks, social networks, sensor networks). New forms of collaborative consumption, collaborative making, collaborative production, all rely on a common task, the formation of collectives. This task is crucial in many real-world applications domains. Notable examples of actual-world collective formation scenarios are Collective Energy Purchasing (CEP), a collaborative consumption scenario, and Team Formation (TF), a collaborative production scenario. Within the Artificial Intelligence literature, current state of the art algorithms cannot provide the level of scalability and the solutionquality required by actual-world collective formation problems, hence novel algorithms are needed to tackle these problems. To achieve this objective, we aim at proposing novel algorithms that are capable to exploit modern highly-parallel architectures. On the one hand, highly-parallel architectures have been successfully applied in many different scenarios so to achieve tremendous performance improvements. These advancements encourage the investigation of parallelisation also in collective formation, with the objective of achieving the same benefits. On the other hand, our past research indicates that considering the structure of the collective formation problem leads to notable benefits in terms of scalability and solution quality. Thus, we propose to take a novel algorithmic design approach that considers both the structure of the scenario and at the same time exploits modern highly-parallel architectures. Our algorithms will be evaluated in two prominent collective intelligence application domains: the CEP and TF domains. The choice of these two applic
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Innovative method to increase fruits' active principles in sherbets' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Nowadays people are interested in living a healthy life, starting from food. Those who are on a diet or have healthy problems such as diabetes or some kind of allergies often exclude ice creams. Sherbets (sorbets and granites"), on the contrary, are produced without milk and fats. Orange, lemon or other types of fruit juice, sugar, and water compose them . At the same time they have a few calories and many benefit compounds and vitamins that have an important role to prevent illness and to carry on a healthy life. Nevertheless, during the producing process, sorbets and "granites" loose many of those vitamins and compounds. The project intends to raise the presence of all the fruits' active principles in order to create product which has the advantage of preventing cells ageing, thank to antioxidants, such as flavorous and antocyanins, and to decrease the rising up of allergies and inflammations thanks to fruits' vitamins ."