RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The hardships for life to become big  – rethinking hypoxia as an evolutionary driver for the rise of complex multicellularity'.

assistant: **Innovation**

Why complex life evolved on Earth has puzzled scientists for as long as sufficient oxygen has been deemed vital. Motivated by recent discoveries, however, this project will investigate the dawning paradox that multicellular life requires low oxygen (hypoxia) internally to thrive in the oxic niche. Central biological mechanisms in animals and plants need protection from oxygen and appears to depend on hypoxic niches. I have previously reconciled geological and medical observations to demonstrate how biological innovation to harness hypoxia would have allowed animals to conquer the previously inaccessible oxic niche. Although life must have invented several solutions to the paradox, the only known is the recent Nobel Prize-awarded mechanism of how cells sense oxygen. Earth history can uniquely evaluate its evolutionary importance through a geologic lens. In ParadOX, I propose to build a transdisciplinary team that provides a novel geobiological evaluation of the role of innovations that harness hypoxia and the processes that led to them.ParadOX will:1) Experimentally definea) Paleozoic oxygenation as kill-mechanism for species with limited access to hypoxiab) Role of hypoxia for invertebrate longevity and life cycle2) Theoretically explorea) Changes in Neoproterozoic shelf area and daily O2 fluctuations as drivers of hypoxia-machineriesb) Co-evolution of hypoxia-machineries in animals and plantsThe project uniquely integrates knowledge from geology, biology, medicine, and numerical modeling.ParadOX’s inquiries groundbreakingly shift our perspective from a simplistic to a dualistic view on the role of oxygen for complex life. Insight to the evolutionary importance and processes that underpin biological innovations to harness hypoxia will advance our view on the rise of mul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Objective testing equipment for vertical spray distribution measurements and integrated prediction software' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Background The introduction of compulsory testing of spraying machines requires a set of standards for testing these machines. All spraying machines must comply with these standards. Orchard sprayers or air blast sprayers, due to their specific nature, will need a specific testing procedure and adjustment technique for what concerns their vertical distribution of pesticides. Until now, no such objective testing procedure or adjustment technique exists. The project aims at developing such a procedure and technique. The package will also incorporate prediction software to assist the user and manufacturer of these machines in the adjustment of the sprayers and in the validation of new designs.  Objectives The objectives of this project are to develop a system for measuring and adjusting the vertical distribution of air blast sprayers with the following target specifications: 1. Repeatability of measurements: coefficient of variation (CV) equal to or better than 1.5%; deviation between any two runs of distribution measurements under controlled conditions: equal to or better than 3%. 2. Deviation between measured spray distribution data and measured dose received on trees under controlled conditions: equal to or better than 15%. 3. Modelling performance (integrated optimisation system): deviation between predicted and measured distribution: equal to or better than 10%.  Work programme In a first stage, a study will be carried out on sensor and aerosol modelling. Several principles for developing a suitable measuring technique will be investigated and one or more experimental sensors with associated electronic circuitry (input/output circuits, data acquisition and data display) realised. Sensor behaviour both in the laboratory and in the field will be monitored with a single
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Distributed equipment Independent environment for Advanced avioNic Applications' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The DIANA Project is the first step for the implementation of an enhanced Integrated Modular Electronics (IME) platform, providing secure distribution and execution on virtual machines to avionics applications. DIANA will define and standardize the development and certification means needed to support the new platform. The following activities will be performed in DIANA 1.Definition and evaluation of an example IME platform, including a.Object Oriented (OO) avionics applications running on virtual machines (like Java Virtual Machine,JVM) b.Services supporting secure distribution (like CORBA) for avionics applications 2.Definition of the development means, based on the Model Driven Engineering (MDE) approach 3.Definition of the certification means 4.Standardisation of the results of the project Today, the development of avionics software accounts for 85% of the cost of the development of avionics. The application in IT systems of the techniques above (MDE, OO, CORBA,JVM) has achieved reductions of up to 80% of the costs of software development. Introducing the use of these techniques in avionics software, DIANA will contribute to the reduction of the aircraft development costs and to the reduction of the aircraft operating costs, enabling a faster upgrade and replacement of the avionics applications and contribute to the reduction of on-board weight through a better use of computational resources. Supported by major European manufacturers and well recognise air framers, the DIANA project will be run by a strong management team from a leading SME in the area of avionics. Community Added Value will be obtained by pulling together expertise from different Companies and Universities across different countries, to perform the development of the platform. Improvement in Europe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Human Stem cell-based technologies to model PARKinson’s disease and drive patient-specific cell therapy' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Loss of dopaminergic (DA) neurons in midbrain underlies motor dysfunction in Parkinsons disease (PD). PD is one of the most challenging neurodegenerative diseases to study due to the limitations of existing model systems in recapitulating its complex etiology resulting from individual risk variants, distinct genetic and epigenetic backgrounds, and age-related environmental triggers. The SPARK project (Human Stem cell-based technologies to model PARKinsons disease and drive patient-specific cell therapy) will use induced pluripotent stem cells reprogrammed from PD patient-derived somatic cells as well as from age- and sex-matched healthy individuals to model key aspects of DA neurodegeneration. Advanced human stem cell-based technologies including brain organoids and cell transplantation will be exploited to recreate functionally mature human DA tissue in an ad hoc disease-like environment. A single-cell sequencing approach will be used to obtain molecular insights into PD etiopathogenesis and the pathological mechanisms responsible for DA neuron degeneration. Lastly, gene editing in a patient-specific genetic background will be performed to create an autologous source of healthy DA neurons reverted from the disease-related phenotype. These cells will be pre-clinically validated in a PD rat model, with a view to ultimately achieving autologous cell replacement treatments for PD.


**Keywords:** Regenerative medicine, Parkinson´s Disease, induced pluripotent stem cells (iPSCs), human brain organoids, cell-based therapy, single cell sequencing
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Methodology for electromagnetic susceptibility analysis' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

The purposes of the MESA project are to develop a first quantitative approach by combining three different ways:- a methodological analysis for EM susceptibility- a new equipment which may be used for the evaluation of electromagnetic coupling functions between EM sources and sensible equipmenta numerical code calculating the various coupling functions of the site which may be used for the optimisation of the electromagnetic protections.A new methodology for susceptibility analysis is now accessible and may be considered as a first step for solving EM problems on industrial sites:a testing equipment is available to achieve tests on various sites for different operational configurations. This equipment, operating between a few volts to 20 kV, generates incident pulsed waveforms and may be able to detect and record corresponding perturbations on equipmenta numerical tool based on the new concept of the Electromagnetic Topology is now available and may be used on operational sites to calculate full threat perturbations and to define optimised protections.Finally, MESA may be considered as a first step in the quantitative approach of the electromagnetic protection of industrial sites; it has to be completed by a more applied program including optimised protection techniques and new standards.BackgroundVarious sites for industrial or commercial activity such as airports, communication networks, industrial plants, hospitals, banks etc may be severely affected by electromagnetic sources. On major installations, electromagnetic protections are already recommended; these protections are essentially based on empirical definitions: no measurements and no quantitative evaluation are proposed for the moment.Work programmeWPO - Project management: this task was done by ONERA (Fr)WP1
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Polymer mechanics via Function spaces' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Polymers are three-dimensional, flexible materials composed of macromolecular chains interconnected by crosslinks, which are indispensable in everyday products. Accurate computation of these materials is crucial to avoid trial-and-error synthesis, thereby extending polymer lifetimes and minimizing production waste. To date, continuum mechanics is the only discipline capable of achieving large-scale multi-physics computation of polymers. However, complex mechanical behaviors of polymers present significant challenges, necessitating the development of unconventional continuum theories and advanced machine learning techniques. While the former facilitates the capture of both local and nonlocal behaviors of polymers, the latter ensures model reliability by utilizing rich information from large datasets. Unfortunately, current machine learning approaches, when coupled with immature continuum theories, suffer from limited interpretability and an ad hoc nature. This underscores the need for a theoretically grounded machine learning approach to drive genuine advance in human knowledge.PolyFun aims to enable machine learning not only to recognize pattern, but also to develop a deeper understanding of data through the principles of continuum mechanics and polymer physics. This will be achieved by representing polymers as reproducing kernel Hilbert spaces and defining their structural and topological properties via these physical insights. PolyFun consists of two stages. Stage 1 focuses on learning from polymeric data and the domain knowledge of continuum and polymer mechanics. Stage 2 extrapolates understanding gained in Stage 1 to learn from real-world data and further enhance the computational scalability of the methodology. PolyFun’s unique perspective serves as a unified scie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deciphering subsurface carbon fixation' (SUBCARB), addressing dissemination and exploitation.

assistant: **Impact**

Despite containing the vast majority of carbon on the planet, the Earth’s subsurface represents a mostly uncharacterized frontier for biogeochemistry and microbial ecology. While carbon fixation at the Earth’s surface has been drawing a lot of attention for decades, subsurface carbon fixation remains poorly understood. Yet, metabolically, it engages a rich diversity of non canonical pathways, contrasting to surface carbon fixation dominated by the canonical Calvin cycle. Also, its contribution to the global carbon cycle, though long overlooked, is now garnering increased attention. In recent years, several studies aiming to characterise the diversity of carbon-fixing organisms within the subsurface have emerged. However, these studies are isolated and do not accurately describe the dependence of these metabolisms on the geoenvironmental context. I propose here to provide a blueprint of subsurface carbon fixation on Earth. In a top-down approach, I will systematically sample various subsurface environments for metagenomic and metaproteomic analysis of carbon fixing metabolisms, in search of the main environmental factors determining the carbon fixation strategy used. In parallel to this, I will undertake a bottom-up experimental approach to explore and confirm this metabolic versatility in response to changing environments, through controlled culturing experiments. Finally, I will integrate the acquired results with stable isotope analysis to build a metabolic model, aiming to comprehensively predict carbon fixation fluxes in function of the geoenvironmental context. The proposed holistic approach will increase our understanding of the role of subsurface microbial metabolisms in global carbon cycling.


**Keywords:** Carbon fixation; Subsurface environments; Metagenomics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Environmentally sustainable data centres for Smart Cities'.

assistant: **Objectives**

Data centres are involved play two different and complementary roles in Smart Cities' energy policies with two roles: as ICT infrastructures supporting Smart City resource optimization systems - and more in general, delivering for ICT services to the citizens - and as large energy consumers. Therefore there are huge expectations on data centres being able to run at the highest levels of renewable energy sources: this is the great challenge of DC4Cities project.DC4Cities addresses these requirements optimizing data centre operations as well as software running in the data centre for minimal energy consumption and adaptivity to external energy constrains, targeting the 80% usage of renewable energy sources.The goal of DC4Cities is to let make existing and new data centres become energy adaptive, without requiring any logistics modification to the logistics, and without impacting the quality of the services provided to their users. Finally new energy metrics, benchmarks, and measurement processes will be developed and proposed for the definition of new related standards.DC4Cities will promote the data centres role as an eco-friendly" key player in the Smart Cities energy policies, and will foster the integration of a network of local renewable energy providers (also interconnected with local Smart Grids and microgrids) to support the pursued increase of renewable energy share."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'Characterisation of stat5 serine kinases in t lymphocytes'.

assistant: **Concept**

Research objectives and content The phosphorylation of STAT5 (signal transducers and activators of transcription) activates gene transcription leading to the growth and acquisition of effector functions of -lymphocytes. This phosphorylation has been described as occurring on tyrosine residues but, very recently, D Cantrell's group has shown that a serine phosphorylation was also involved in STAT5 activation. Interestingly, the serine phosphorylation seems to be required for transcription activation by STAT5 following IL2 stimulation. Additional experiments have shown that none of the known pathways that could lead to he serine phosphorylation of STAT5 (MAP-kinase and phosphatidylinositol 3kinase) were involved in that newly described form of STAT5. Therefore, the IL2-activated serine phosphorylation results from a previously uncharacterised serine kinase. The aim of this project is to identify this protein, describe the pathway leading to its activation, and work out its involvement in T-lymphocyte response to IL2. Training content (objective, benefit and expected impact) The training objective is to deepen my knowledge of T-lymphocyte activation by studying the intracellular signalling following their stimulation. Its benefits will be 1) to get expertise in analysing signal transduction, which is a key step to every immunological process and 2) to interact with leading researchers in immunology and biochemistry. The knowledge and the scientific contacts gained will be applicable in most areas of lymphocyte biology and beneficial to any European group I may join after this post-doctorate.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Novel analytical electron microscope for basic and industrial research' demonstrating excellence, impact and implementation quality for a Fourth Framework call.

assistant: **Abstract**

The novel analytical electron microscope to be developed in this project will be based on a patented new principle called double-reflection-electron-emission microscope (DREEM). This method provides a resolution about 20 nm, in-situ electron diffraction for geometrical microanalysis and in-situ electron spectroscopy for chemical microanalysis. The DREEM can image the distribution of a selected element very fast, in favourable cases even with video frequency. This is principally impossible using any other existing technique. The goal of this project is twofold: First, a prototype instrument of the DREEM shall be developed and second, the applications of the new microscope shall be explored by research partners from different disciplines (materials research, surface physics, nanotechnology, analytical chemistry, biology, medicine).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainable Energy for Society', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Sustainable Energy for Society (SE4S) COFUND programme, coordinated by Fundación Iberdrola España (FIBE), aims to recruit and train 16 excellent postdoctoral researchers through a single international call. SE4S addresses major global challenges such as climate change, biodiversity loss, and resource scarcity. It builds on the strategic priorities of FIBE and the Iberdrola Group, with a strong focus on sustainability, innovation, and decarbonisation. Research activities will be structured across three interrelated and strategic areas: 1-Decarbonised Energy Systems, 2-Biodiversity and Ecosystems Quality, and 3-Circular Economy.SE4S aims to contribute to the development of a new generation of researchers equipped to drive Europe’s clean energy transition and sustainability goals. The programme supports interdisciplinary, intersectoral, and international training and research. Fellows will benefit from excellent research environments and attractive working conditions, including access to high-end infrastructure, supervision by experienced mentors, and tailored training in both technical and transferable skills. SE4S is implemented by a consortium of 19 partner organisations (11 implementing and 8 associated) from 10 countries, covering both academic and non-academic sectors. SE4S promotes structured collaboration between host institutions and associated partners, encouraging joint research initiatives and cross-sectoral knowledge exchange. All fellows will complete a mandatory secondment in the private sector, hosted by Iberdrola Group companies, to ensure exposure to industrial innovation and foster career development beyond academia.


**Keywords:** Energy; Decarbonization; Biodiversity; Ecosystems; Circular Economy