RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Development of a non-invasive medical device to measure the skin biomechanical properties: assessment of the commercial feasibility' to be submitted under Horizon Europe.

assistant: **Abstract**

Skin pathologies including wounds, scars and tumors represent important public health issues. (e.g. melanoma is the first cancer in terms of increasing frequency). Moreover, skin firmness is an essential property aimed by cosmetic products. However, skin assessment methods remain based on empirical considerations and it is still difficult to determine the skin biomechanical properties, which prevents developing a personalized medicine approach. Such medical device is needed by the physicians to adapt the therapeutic strategy and by the cosmetic manufacturers to develop and validate their product, and to propose the optimal product in a customer-specific manner.AssesSkin is based on results obtained in the ERC CoG project BoneImplant and aims at developing and validating a medical device consisting in a decision support-system allowing to assess the skin biomechanical properties. The objectives of AssesSkin are i) to achieve a minimum viable product that will be validated in vitro and in vivo, and ii) to investigate its commercial potential and design an exploitation strategy via spin-off creation or licensing. We will explore the possibility to license the technology to ImpacTell, an already existing spin-off of the same laboratory. The originality is to use an impact-based measurement method, which allows to obtain a non-invasive, cheap and easy to use medical device.Regulatory issues will be at the heart of the development and we will work in order to clear the regulatory pathway of the future medical device. The team is constituted by members with complementary skills (engineers, a business developer, a dermatologist and a plastic surgeon).AssesSkin will allow the promotion of innovative solution and services in dermatology, plastic surgery and in the cosmetic indust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Changes in land access, institutions and markets in West Africa' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

This project will investigate the changing ways in which different groups gain access to land and other resources in West Africa, and the evolution of institutions through which claims to land are made. Field studies will be undertaken in Benin, Burkina Faso, Cote d'Ivoire, and Mali in places where land and other resources are increasingly scarce and subject to rising competition, to assess the impacts of land policy, legislation and interventions on the security of land claims. Emphasis will be given to ensuring effective dissemination of research findings through a variety of media, combined with a Participatory Learning Group on land to promote engagement with policy makers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'European Communication on Research Awareness Needs' under Seventh Framework.

assistant: **Concept**

The ECRAN (European Communication on Research Awareness Needs) project is designed to develop a portfolio of open educational resources, including a film, for the general population about the challenges raised by independent clinical research.The European Commission (FP7 Health Priority) decided to allocate substantial funding to independent (investigator-driven) clinical trials. Together with member states, the FP7 infrastructure unit supports the preparation and operation of a pan-European infrastructure for clinical trials (ECRIN). Through these instruments, Europe has the capacity to design and conduct independent, multinational clinical trials.The objective of the ECRAN project is to develop tools to communicate key messages to citizens, patients, healthcare professionals, researchers, policymakers and society about independent, multinational clinical research. These messages will focus on:i) the importance of public understanding of the need for and basic principles of clinical trials, fostering active involvement of patients in trials and of their representatives in trial design;ii) the need for independent clinical trials driven by healthcare issues, to optimise treatment strategies through comparison of benefits and harms of multiple therapeutic options, supporting evidence-based clinical practice and reduction in healthcare inequalities;iii) the need for transparency and optimal use of data, to promote the cost-effectiveness of treatments and to reduce the economic burden of diseases;iv) the need for multinational cooperation, taking advantage of Europe’s population size and diversity, and of its medical expertise.These objectives will be addressed using communication tools, including: a website, with an online database of open educational resources in differe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Single-photon nanostructured detectors for advanced optical applications' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

This project targets the development of near-infrared single-photon optical detectors based on nanostructured superconductors. These detectors will achieve ultimate sensitivity and temporal resolution for application in long-distance optical communications, quantum cryptography, diagnostics and testing, and remote sensing. We will pursue the following objectives:- Fabricate single-photon optical detectors with unprecedented performance at telecom wavelengths (four orders of magnitude more sensitive and three orders of magnitude faster than commercially-available avalanche photodiodes and photomultipliers)- Demonstrate their implementation in several IST applications by industrial partnersIn order to achieve these goals, the following approach will be taken:- Material development, nanofabrication and optical characterisation will be pursued by academic and public research institutions- Applications will be demonstrated by SMEs and major industrial players with a leading position in optical communications, professional electronics and advanced optical technologies.The project will make an impact on European competitiveness by:- Advancing the state-of-the-art in strategic nanomaterials- Providing the European industrial and scientific community with a tool whose performance will open new opportunities for industrial use and fundamental science- Facilitating the industrial take-up of a nanophotonic technology by spanning the value chain from devices to applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'A Chemical Genetics Approach towards Cancer Therapy Targeting Histone Demethylases' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Cancer is one of the most common causes of death in the EU. The disease is characterized by aberrant gene activity in certain cells. Even today, cancer therapy is little focused, which is reflected by severe side effects. Consequently, there is a need for novel and better tolerated therapies.In this proposal an approach to validate a new class of enzymes as targets for cancer therapy is presented. In the cell nucleus, DNA is bound to special proteins, called histones, which play key roles in gene regulation. Histones can be dynamically modified with special marker groups, which allows the control of gene expression without alteration of the DNA itself. Specifically, it is intended to inhibit histone demethylases, specialized enzymes which remove certain marker groups (methyl groups) from histones, which results in gene silencing or activation. Histone demethylases are known to be upregulated in certain cancers and are therefore promising candidates for pharmacological cancer therapy. Ideally, small molecule inhibitors will inhibit cancer growth and might even be able to restore the normal genetic program of a cell.During the study specific small molecule-enzyme pairs will be created, which allows the study of a single enzyme among very similar ones. This chemical genetics approach encompasses the mutation of the enzyme and the synthesis of specifically tailored small molecules. The properties of the enzyme-inhibitor pairs will be evaluated by in vitro assays and crystallization. Afterwards the compounds will be used to decipher the role of the histone demethylase in cell culture models by microarray methods and RNA sequencing.The study will be very interdisciplinary and encompass chemical synthesis, biochemistry, cell biology and structural biology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Spatiotemporal models of tissue patterning and cellular commitment during embryonic development' (EmbryoAxes), addressing dissemination and exploitation.

assistant: **Impact**

One of the most remarkable processes in biology is how animals develop from a single fertilized egg within a short time of rapid growth and an explosion in spatial and cellular diversity. Embryonic development is highly deterministic and consistent among different embryos and conserved across species. Astonishingly, embryos reuse the same signaling pathways in diverse developmental contexts to robustly pattern tissues. The advent of single-cell genomics in the last decade has allowed to chart the phenomenology of cellular differentiation at unprecedented resolution and scale. Yet, moving from such single-cell descriptions to models of how embryonic tissues achieve robustness and precision in their differentiation remains exceedingly difficult. To this end, we will develop new algorithms that will infer the spatiotemporal dynamics of differentiating tissues from space-, time- and lineage-resolved data. Tissues will be modelled as groups of proliferating and interacting cells distributed in space and moving along transcriptional, epigenetic and signaling manifolds. Focusing on the developmental stages of gastrulation and early organogenesis, we will reconstruct the spatiotemporal trajectories of cells together with the dynamics of their local niches. These trajectories will serve as the input to mathematical models that will predict local changes in a cell’s state from its signalome, epigenome and transcription factor repertoire. Using zebrafish embryos as a high-throughput system of vertebrate development, we will systematically test these models through time-dependent, combinatorial perturbations with a multiomic read-out. My overall goal is to develop quantitative, data-based models of how transcriptional, epigenetic and intercellular changes at the cellular level tran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'DNA Based Nanoelectronics', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

We propose to study electrical transport in two types of one-dimensional DNA-metal hybrid systems: (a) DNA modified gold nanoparticles pearl chains, and (b) DNA templated metal nanowires. We will analyse systems type (a) in two steps. First, we will study the transport through very short thiol functionalized single DNA molecules using the mechanically controllable break junction (MCBJ) technique.This method allows obtaining electrodes where their separation is controlled with sub atomic precision. In this step, we will give an emphasis to the following issue: What is the conductance of various short DNA molecules, and is it sequence dependent? This information we will use in the next step to engineer gold colloids-DNA chains. We will study the chains in three-terminal (transistor) geometry. In parallel we will fabricate systems type (b) from different metals, of various lengths and diameters. We will analyse the transport through these systems in detail by attaching them directly to metallic electrodes. A synergetic influence of chemical and physical properties of nanowires on charge transport will be studied in order to obtain systematic characterization.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Global allergy and asthma european network' (2002-2006), addressing dissemination and exploitation.

assistant: **Impact**

Allergic diseases and asthma pose an important and increasing problem for Europe. European research groups already make a major contribution to studies of the causes and management of these conditions. Initiatives from the European Commission have led to increasing collaboration within Europe, but there is still a lack of permanent structures and there are relatively poor links between disciplines. A network of excellence (NoE) will be the optimal answer to these problems. GA²LEN (Global Allergy and Asthma European Network) is a NoE of 25 leading European teams, the European Academy of Allergology and Clinical Immunology (EAACI) and a patient's organisation (EFA). The objective is to establish an internationally competitive network, to enhance the quality and relevance of research, address all aspects of the disease, and eventually to decrease the burden of allergy and asthma throughout Europe. The network will bring together epidemiological, basic and clinical researchers carefully considering ethical and gender issues. It will investigate allergy and asthma across the life course, including intra-uterine life and foeto- maternal interface; interaction between genetic and environmental factors in early life, translation of allergic sensitisation into disease, and, persistence of the disease. This will allow development of novel biomarkers, treatments and preventive strategies. GA²LEN will create a permanent and durable structure that will maximize the scientific contribution of Europe to this area. The network will accelerate the application of research results to clinical practice, patients' needs and policy development, as well as promoting training and integration between public and private sectors'.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Mechanisms underlying hepatocellular carcinoma pathogenesis and impact of co-morbidities.'.

assistant: **Innovation**

Hepatocellular carcinoma (HCC) is the most common liver malignancy, with an estimated 750,000 new cases and 695,000 deaths per year, rating third in incidence and mortality in the world. Whilst incidence and mortality for other cancers are declining, HCC represents an increasing public health problem in Europe with men having a higher incidence than women. Several liver diseases lead to HCC and become per definition co-morbidities, such as nonalcoholic steatohepatitis (NASH) or hepatitis B and C virus infection. Most patients die within one year of diagnosis and treatment failure reflects the heterogeneous nature of this tumour, highlighting the need to identify common and co-morbidity specific disease pathways for individualized therapy. HEP-CAR will focus on three leading HCC associated co-morbidities, specifically NASH and hepatitis B and C infection. Non-biased genetic and lipidomic screens will define cellular pathways that are deregulated in HCC and the impact of co-morbidities and gender. Next to established patient cohorts, several in vitro and in vivo models are available to evaluate the role of co-morbidities as drivers of host oncogenic pathways and to provide much needed pre-clinical models for mechanistic studies and future drug screening. We will develop new approaches to study the impact of co-morbidities on HCC immunobiology, ranging from state-of-art tissue explant models to novel humanized mouse models. The aim of HEP-CAR is to define host pathways that impact HCC pathogenesis and to assess their role in different co-morbidities and treatment responses. The research and clinical excellence will be combined with the knowledge transfer and communication competence of leading organizations such as the European Association for the Study of the Liver (EASL)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Research on Cooperative and Social Enterprises in Transition Contexts' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

RECOSET aims to stimulate the creation of a network among research centres that are committed to studying cooperative and social enterprises in EU/AC and TC. The societal interest in cooperative and social enterprises stems from their capacity to sustain the welfare of individuals and families, to fight social inequalities, and to enhance social cohesion and solidarity behaviours through the production of a wide spectrum of general interest services (ranging from health, social and cultural services to the work integration of disadvantaged workers), heavily affecting the welfare and political systems. Despite the growing number of individual researchers and research centres involved in studies concerning this theme, a general consolidated literature on the matter is still lacking. The lack of uniformity, coupled with a poor understanding of cooperative and social enterprises’ roles in contemporary societies and economies, prevents the enhancement of awareness of policy makers and practitioners on the potential of cooperative and social enterprises and thus jeopardizes the sector’s development. Against the background of overcoming the lack of a common theoretical framework and empirical methodologies in this field, RECOSET promotes the exchange of researchers (both early-stage and experienced). Furthermore, given the goal of establishing a lasting cooperation among the beneficiaries ,the exchange of one staff member from EURICSE specialised in networking activities is promoted. As for Third Country, the main goal is to give researchers the opportunity to benefit from the theoretical and empirical knowledge that has been accumulated so far by the EU/AC research centres involved. Researchers from EU/AC countries will be offered the opportunity to broaden the geographical r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'From plants for plants: enhancing crops potential and resilience by reliable new generation biostimulants' (2014-2020).

assistant: **Innovation**

Objective of the innovation project is the worldwide market introduction of a new generation of plant-derived biostimulants able to enhance crops yields without resorting to chemical inputs and to improve plant resilience to climate change in a stable, reliable way.  With the conventional cropping systems, the potential of cultivated plants is close to the maximum. Moreover, climate change impacts (drought, extreme temperatures, etc.) are on the rise, putting further constraints to yields and challenging food security. Meanwhile many fertilizers are outlawed by ever-stricter environmental laws, leaving farmers and industry in search for alternatives. Pressures which are reinforced by a rising demand for healthy and eco-friendly products. Landlab biostimulants have been designed as an answer to these challenges. Breakthrough is the opening of a new and precise pathway, much more similar to the pharmaceutical/natural product industry than to current agricultural one. This will lead to the buildup of a strongly integrated source-to-sink production chain, able to generate a flow of innovative products, specifically tailored on critical stages and conditions of manifold crops and supported by accurate identification of their active compounds and by efficacy studies, as to counter the main drawback of state-of-the-art biostimulants: their inconsistent stability of performances.In order to transform these R&D outcomes into successful products, 1st aim of the feasibility study is to assess the most convenient direction of prototype demonstration and market introduction efforts. Technical and market data will be crossed with cost analysis to identify which biostimulants launch first and benchmark the potential business models. Then matured information will be elaborated into a b