RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Technological Evolution, Social Processes and Environmental Impact as Reflected in Bronze and Iron Ages Copper Exploitation in Timna, Israel (the Central Timna Valley Project, CTV)' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The proposed project focuses on the complex relationships between past human societies and natural resources and the role technology and technological developments played in human-environment interactions and related social processes. The case study concerns Late Bronze and Iron Age (ca. 1500 – 500 BCE) copper exploitation at Timna, a remote valley in the desert of southern Israel. The project includes several seasons of field work and supplementary laboratory analyses, integrating tools from the Natural Sciences and anthropological perspectives. Several hitherto unexcavated smelting and mining sites will be surveyed and excavated in order to address a number of key issues in the archaeology of the southern Levant, the archaeometallurgy of copper and iron, and sustainability of early industrialized societies. More specifically, the proposed research will address questions concerning innovations in smelting technologies, the introduction of iron metallurgy and its related technological problems, historical issues concerning the nature of 13th – 9th c. BCE emerging desert polities (including the Kingdoms of ancient Israel and Edom) and the impact of the intense copper production on social processes, regional and global political interactions and the economy of the southern Levant throughout that time period. To address these issues, the project will put emphasis on stratigraphy and chronology (utilizing AMS radiocarbon dating, archaeomagnetic dating, and optically stimulated luminescence [OSL]), and on micro-archaeological investigation of metallurgical installations (utilizing portable XRF in the field, and several microscopic tools in the laboratory). As part of the project an online digital database will be implemented in order to facilitate the management of field and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Fuel cell systems and Hydrogen supply for Early markets' (LiquidPower) targeting Seventh Framework.

assistant: **Abstract**

The LiquidPower project addresses the topic “SP1-JTI-FCH.2011.4.3 aiming on developing a new generation fuel cell systems for the early markets of back-up-power/telecom (BT) and material handling vehicles (MH) as well as a new innovative hydrogen supply method based on onsite methanol reforming. The LiquidPower project objectives are:R&D of a fuel cell system for Back-up-power and Telecom applications (BT), reaching full commercial market targets by 2015.R&D of a fuel cell system for material handling vehicles (MH), reaching full commercial market targets by 2015.R&D of a methanol reformer for onsite Hydrogen supply, enabling supply of low cost hydrogen for the early markets of BT and MH. Focus on reduced system cost and improved efficiency and outlet pressure.For each of the developed technologies, laboratory tests are to be conducted in order to validate reaching of the technical and market targetsContinued R&D efforts are to be planned and secured initiated as well as securing patents on the developed technologies.The participating companies are to plan and secure initiation of following commercialisation & product maturation in order to ensure a commercial exploitation of the developed technologies.Project results and experiences are to be disseminated throughout Europe to the hydrogen and fuel cell industry as well as the BT and MH industries, in order to identify further collaboration partners up- and downstream the value chain.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'GLOBAL NAVIGATION SATELLITE SYSTEMS SUPPORT' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

GNSS will study the operational requirements for current and future satellite navigation systems in the road, rail, maritime, aviation and survey sectors. Backed by a user group, the study will define the operational and functional system requirements as a basis for recommended optimum architectures along with a cost-benefit analysis. A scenario will then be proposed for the transition from the current system which depends on the use of military systems (GNSS 1) to a fully civilian system (GNSS 2). Benefits of the navigation system are expected in all forms of transport and in many other applications requiring accurate position and/or time determination.A recognised and regulated civil global navigation satellite system (GNSS) does not currently exist. However a great many users are making unregulated use of signals from GPS for position fixing and for navigation in numerous application areas. A regulated quasi civil satellite navigation system (GNSS1) is currently being developed in Europe that will allow significantly more users to benefit from the existing military satellite systems. This will be accomplished through the provision of redundancy and augmentation to overcome the deficiencies of the core" systems. With adequate diversity and independent monitoring, some of the "institutional" issues may become less significant for those non-safety critical applications. For the future, a fully civil controlled satellite navigation system (GNSS2) has been proposed.This study will be undertaken in support of the European GNSS programmes, and has the following objectives. 1) Define the operational requirements for a GNSS. 2) Define the functional requirements for a GNSS. 3) Recommend an optimum GNSS1 system architecture. 4) Recommend an optimum GNSS2 system architecture. 5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'International Network of Excellence in Science Technology' (EuroTechPostdoc) targeting Horizon 2020.

assistant: **Abstract**

Combining complementary research & innovation strengths with unique infrastructures across four leading European Universities of Science & Technology will provide the basis for an internationally competitive fellowship programme. The new EuroTechPostdoc programme aims at attracting excellent experienced researchers from all over the world through an open, transparent and structured recruitment process. EuroTechPostdoc will provide exceptional research and training opportunities for up to 80 experienced researchers funded for a 2-year period (divided in 2 calls, 10 fellowships per participant per call). The fellows will develop their skills in interdisciplinary collaboration projects between at least two participants from two different European countries, and will be provided with the opportunity to transfer knowledge in entrepreneurship activities or by collaboration with public and industrial organisations from the combined networks of the participants. The research programme has been carefully selected to provide the fellows with the complementary strengths, established networks and industrial collaboration in areas of high relevance to the EU’s industrial leadership: Health & Bioengineering, Smart & Urban Mobility, Data Science & Engineering, High Performance Computing, Entrepreneurship & Innovation. The fellows will gain access to the excellent and complementary training options offered at the four participants, and will be supported by a personal supervision and mentoring scheme, as well as excellent local support structures. The EuroTechPostdoc 3-days Workshop focuses on strengthening the fellows’ skills and network, preparation ahead of their careers and to foster further collaborative projects between the fellows. Together with outstanding working conditions tha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ERA-NET on National and Regional Programmes to Promote Innovation Networking and Cooperation between SMEs and Research Organisations – Phase 2' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

The proposed new EraSME ERA-NET, dubbed EraSME² will build on the successful work of the original EraSME project. The experimental phase of EraSME is now closed. The coming two years will be the consolidation phase, devoted to ensuring the long-term sustainability of EraSME by setting up an integrated transnational programme to support SMEs. During this phase the project will implement a formal management and organisation structure for EraSME; further develop and improve joint procedures for: the programming of calls and related activities including common evaluation criteria (“scientific integration”); the management of call handling and evaluation procedures  (“managerial integration”); the funding of selected projects (“financial integration”); widen selectively the partnership to additional programmes, regions and countries; launch further joint calls for proposals every six months, raising the number of participating countries, regions and programmes, of proposals submitted, and of proposals funded.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Spliceosomal Processes in Nucleomorphs' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The ""Splicing Processes in Nucleomorphs"" (SPiN) project leverages the unique properties of nucleomorphs to explore in situ the nuclear architecture and gene expression at an unprecedented level. Using cutting-edge cryogenic electron microscopy (cryo-EM) techniques such as tomography, subtomogram averaging and single particle analysis, I want to provide novel understanding of how pre-mRNA splicing happens in the context of genome reduction. I will overcome the limitations of current cryo-ET studies of the nucleus that struggle with the large size and dense environment of typical eukaryotic nuclei. Nucleomorphs, with their small size, enable a more accessible and efficient approach to in situ studies, bypassing the need for complex sample preparation steps.The SPiN project is structured around three specific aims: (1) isolating intact nucleomorphs for comprehensive proteomics and transcriptomics and structural analysis, (2) purifying and structurally characterizing spliceosome complexes unique to nucleomorphs, and (3) visualizing the structural landscape of nucleomorphs to understand the spatial organization of gene expression targeting spliceosome structures for in situ structural determination. By establishing nucleomorphs as a powerful model for in situ studies, this project promises to uncover new insights into pre-mRNA splicing mechanisms and nuclear organization, with far-reaching implications across evolutionary biology, cell biology, and biotechnology. The potential for groundbreaking discoveries positions nucleomorphs as a transformative tool to advance our understanding of eukaryotic genome evolution and the mechanisms underlying nuclear processes.""


**Keywords:** pre-mRNA splicing, spliceosome, nucleomorph, in situ, gene expression, cryo-electron tomography
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Computing the structure and dynamics of protein assemblies in living cells by coupling sub-diffraction fluorescence microscopy with single-particle reconstruction: application to viral capsids' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Electron microscopy (EM) is an invaluable tool for investigating the nanometer-scale organization of molecular assemblies such as viruses, but is restricted to dead cells, does not readily label targeted proteins, and is prone to fixation artefacts. Recently developed methods to break the diffraction limit in optical microscopy have the potential to resolve protein arrangements in living cells. However, their resolution is currently restricted to ~20-30 nm, still an order of magnitude removed from EM, and dynamic super-resolution imaging remains challenging. Here, we aim to reconstruct the protein arrangements of molecular structures at resolutions better than 20 nm by harnessing the power of statistics, i.e. by aggregating images from hundreds or thousands of copies of nearly-identical structures and when possible by exploiting their symmetry. To do this, we will adapt computational methods of single particle reconstruction from electron microscopy to super-resolution optical microscopy. After validation on synthetic data, we will test and apply these methods to nuclear pores and adenovirus capsids. These examples have been chosen because of their geometric features that work well with our approaches. Particularly, we are interested in obtaining novel insight into the dynamic structural changes occurring at the nuclear pore complex during active transport. Furthermore, we aim to decipher the sequence of events during viral capsid formation. This work has the potential to further push the resolution of optical microscopy towards that of electron microscopy for the analysis of ordered molecular assemblies. If successful, our project will open the door to structural investigations in living cells, including the assembly process of viral particles, or the plasticity of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Environmental Proteomics: Methods development and characterization of proteinaceous compounds in environmental samples' to be submitted under Seventh Framework.

assistant: **Abstract**

To date, substantial effort has been devoted to characterize the microbial communities in environmental samples, to understand the role of individual microbes and to unravel the key processes controlling the functioning of various ecosystems. Several culture-based methods and culture-independent DNA-based techniques have been developed for the assessment of microbial diversity, but these have some serious disadvantages (inefficient, laborious, slow, not informative about microorganisms function). Although these approaches enable the phylogenetic analysis of microbial communities, they do not necessary tell us what individual microorganisms can do and if they play any role in ecosystem functioning. The analysis of messenger-RNA has been suggested as an alternative approach for the retrieval of useful information about cell’s major activities, but mRNA molecules degrade very rapidly and their analysis is usually problematic. In the last few years, there has been increasing interest in the potential applications of proteomics in the fields of environmental chemistry and ecology. Recently, proteomics opened a new avenue for the study of microorganisms in the different environmental compartments and the elucidation of their role in biogeochemical processes. Considering that proteins are the end products of gene expression, the identification and characterization of proteinaceous molecules in environmental matrices can provide information not only for the processes taking place but also for the identity of the active microbial species. The key objective of this proposed research project is to develop/optimize an appropriate proteomic workflow that will be properly tailored toward mass-spectrometry based characterization of proteins/peptides in complex environmental matrices.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European network for innovative microbioreactor applications in bioprocess development' (EUROMBR) under Seventh Framework.

assistant: **Objectives**

The objective is to deliver a trans-European network of industrially oriented specialists fully trained in the development and application of microbioreactor (MBR) technology to support development of innovative bio-based manufacturing processes. The specialistis will be trained by leaders in the field and with state of the art equipment and methodologies. MBRs are a promising tool for screening and scale-up of fermentation and biocatalysis processes due to their low production cost, small working volumes, flexibility and their potential for information-rich experiments under well-controlled experimental conditions. In this consortium, we will further develop MBRs for chemical and biochemical screening, paying special attention to MBR parallelization and applicability for different applications. In addition, characterization of experimental uncertainty, development of reactant feeding strategies at micro-scale and coupling of microscale experimentation to automated design of experiments (DoE) will document applicability of MBRs for chemical and biochemical research. To enhance the applicability of microfluidic enzymatic reactors for organic synthesis, we will establish microfluidic chemo-biocatalytic reaction systems that enable rapid characterization of biosynthetic pathways and chemo-enzymatic conversions. This will be underpinned with immobilization methods that permit rapid and reversible binding of a range of biocatalysts and modeling that relates the kinetic data with results from larger scales. Complemented with precisely positioned fluorescence-based sensor arrays, novel nanosensor particle concepts, and integrated Raman and NIR probes, the MBRs will deliver the data-rich experimentation needed for industrial applications. Data processing and information managem
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Biotechnology Information and Knowledge Grid'.

assistant: **Concept**

Purpose of the biogrid project is to conduct a trial for the introduction of a grid approach in the biotechnology industry.This trial consists of two major steps:(i)the integration of three existing technologies and(ii) the production of a working prototype.The existing technologies to be integrated are:(i) PSIMAP agent technology(ii) classification server: Automatic model classification(iii) space explorer: knowledge visualisation technology.Bio Grid will change the perspective of biologists from a partial view of biological data towards a holistic view of documented data seamlessly integrated with expression and interaction data. This constitutes the basis of a next generation research infrastructure for large proteomics and genomics databases.Objectives:The project is focused at the development of an information and knowledge grid allowing knowledge discovery and access to multiple types of unstructured data.Scientific objectives:Effective concept recognition, pattern matching, intelligent data sourcing agents and tagging technology;Automated categorisation in a metadata hierarchy of the specified biotechnology research domain;Detailed functional knowledge management interoperability methodology design;Domain knowledge mapping, implementing a logical domain ontology;Effective integration of agent, classification logic and visualisation technology. Business objectives: Information grid supporting a next generation classification research infrastructure for large proteomics and genomics databases; Efficient transnational enterprise collaboration;Faster time to market biotech innovation.Work description:This section describes the project work plan towards realisation of the objective: to conduct a trial for the introduction of a grid approach in the biotechnology indust
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Chemistry and Chemical Biology of Lipophilic Algal Toxins' (ALGETOX).

assistant: **Innovation**

Improved methods will be developed for isolation of lipophilic marine algal toxins (azaspiracids, pectenotoxins, yessotoxins and okadaic acid analogues) and their metabolites from algae and shellfish. Derivatives such as labelled analogues will also be produced. These materials will be used in collaborative studies to perform toxicology, identify toxin mode-of-action, and develop improved or validated analytical methods (e.g. ELISA, immunoaffinity cleanup, LC-MS). Information obtained will lead to improved regulatory levels for algal toxins and reduced use of animals (3Rs principal) for routine testing of algal toxins in shellfish.