RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Intelligence-Driven Urban Internet-of-Things Ecosystems for Trustworthy and Circular Smart Cities' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

IDEAL-CITIES aims to develop, demonstrate and evaluate an open modular platform for building adaptive Internet-of-Things and Participatory Sensing (IoTPS) based Smart City applications, supported by Big Data analytics and Cloud services. IDEAL-CITIES outcomes will increase urban life quality, safety and inclusivity by enabling citizens and authorities to produce and exchange contextualised distributed intelligence and information in real-time, in a trustworthy and sustainable manner. The IDEAL-CITIES platform will foster the development and uptake of novel IoTPS-based Smart City applications and enhance the associated market base, by demonstrating new feasible ways for providing IoTPS applications and services which can contribute to urban citizen’s well-being and the cities’ circular economy. The IDEAL-CITIES platform will be demonstrated in the context of two fully-fledged IoTPS Applications, with a focus on mobility for the impaired and on citizen safety, in close cooperation with involved communities (a non-profit organisation for the blind and partially-sighted and four municipalities, respectively), validating the utility of the proposed platform and approach.


**Keywords:** Internet of Things, IoT security and privacy, Circular Economy, Participatory Sensing, Pattern-driven intelligence
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Neuroprotective strategies for multiple sclerosis'.

assistant: **Concept**

Despite intensive research on the causes and pathogenesis of multiple sclerosis (MS), the genetic basis of this common cause of neurological disability is still unknown and the complex immunopathological mechanisms underlying brain injury are only beginning to be understood. To date, no curative therapy is available and none of the existing drugs can stop the neurodegenerative process responsible for disease progression. The NeuroproMiSe project represents a highly focussed and integrated effort to investigate in depth the genetic and mechanistic pathways involved in inflammation-induced neurodegeneration, and exploit this knowledge to develop novel candidate drugs for effective neuroprotective therapy. NeuroproMiSe specific objectives are: 1) To identify the major genes and critical pathways associated with MS and inflammatory neurodegeneration. This goal will be achieved through a comparative genetic approach, using an established animal platform suitable for identification of EAE susceptibility genes, and well-characterized, ethnically homogeneous cohorts of MS patients. Through genomic and proteomic screens carried out in animal disease models, further knowledge will be obtained on genes and molecular pathways involved in inflammatory neurodegeneration. 2) To elucidate essential immunopathological mechanisms of neurodegeneration, focussing on innate and adaptive immune responses and on the use of humanized animal models to define new rational ways of developing disease modifying drugs. 3) To develop novel neuroprotective drugs based on targets validated in animal models. In a first step, new therapeutics targeting critical pathways (Ncf-1, TREM-2, TNFR subtypes, ion channels, glutamate receptors, apoptosis) identified by the applicants will be tested and used in com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart CO2 Transformation' (SCOT) under Seventh Framework.

assistant: **Objectives**

Reducing CO2, protecting the environment and our resources but also reducing dependency on raw materials are major societal challenges. In this context, the EU has adopted ambitious goals to reduce greenhouse gas emissions to 80-95% below 1990 levels by 2050. So far, most attention from policy makers and industry has been paid to Carbon Capture and Storage (CCS) which intends to concentrate CO2 and store it into geological sites.The current SCOT project is focusing on an emerging and insufficiently addressed area presenting strong research, market development and economic growth potential: the recycling / utilization of CO2 through its transformation into valuable products via chemical or biological technologies. In addition to reducing net CO2 emissions, this approach brings the benefit of reducing the consumption of non-renewable resources. Indeed, CO2 is no longer considered as a waste but as an efficient resource enabling industries to:- reduce dependency on fossil fuels and primary raw materials for the production of industrial and transportation fuels, basic chemicals, and building materials;- increase the use of renewable energies from intermittent sources (e.g. solar, photovoltaic, or wind) by providing a solution for electricity storage, via the conversion of CO2 into gaseous or liquid fuels in periods where potential production exceeds demand on the grid and would otherwise be wasted.SCOT is the first ever European initiative in the field of CO2 recycling / utilization.Through a stronger coordination of efforts among the consortium, the SCOT project will enable to:- define a Strategic European Research Agenda aimed at developing new breakthrough solutions and market applications- attract additional EU clusters, regions and investors to participate to multi-dis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Minuscule Texts: Marginalized Voices in Early Medieval Latin Culture (c. 700–c. 1000)' (MINiTEXTS), addressing dissemination and exploitation.

assistant: **Impact**

MINiTEXTS seeks to systematically study early medieval minuscule texts, i.e. short texts of which large numbers were added to blank spaces of Latin manuscripts from c. 700 to c. 1000 and which manuscript scholars refer to as “microtexts,” “guest texts,” or “additions.” Unlike such manuscripts’ main texts, minuscule texts are seldom characterized by identifiable authors or easily traceable histories of textual transmission. As a result, textual and cultural historians tended to either neglect them or compartmentalize them within highly specialized disciplines. By contrast, MINiTEXTS examines minuscule texts across commonly accepted disciplinary boundaries, as a unique corpus of practical knowledge deeply embedded in the social praxis of early medieval society. By establishing the first taxonomy of such texts, MINiTEXTS will fill a significant gap in knowledge of their production, use, and functions. Further, MINiTEXTS aspires to understand the “social logic” of minuscule texts as well as the social, religious, and cultural practices that they signify by developing a transferable methodology inspired by theoretical insights and methods of cultural history, material philology, material codicology, performative theory, and digital humanities. By analyzing historical, textual, codicological, and performative contexts of individual minuscule texts and setting the resulting microhistories within a longue durée perspective, MINiTEXTS promises significant gain in the understanding of early medieval heterogenous culture. MINiTEXTS will thus allow the hitherto marginalized voices of early medieval manuscript culture to be articulated in the current debates over several intertwined issues of medieval cultural history, such as the correlation between the norm and diversity in liturg
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Triple negative breast cancer control through synergistic inhibition of EGFR and CDK9 signaling' (TRIPLECON) targeting Horizon 2020.

assistant: **Abstract**

Triple negative breast cancer (TNBC) is an aggressive disease, accounting for 15-20% of breast cancer cases, but disproportionally causing breast cancer-related death. TNBC does not express the targetable receptors ER, PR, and HER2 that are known to drive other forms of breast cancer. Mainstay practice for TNBC in the clinic is to treat with non-targeted cytotoxic chemotherapies. Long-term outcomes are however still poor, most likely owing to intrinsic drug resistance. Clinical trials have attempted to explore molecular targeted therapies to block dysregulated growth factor receptors in TNBC, for instance, epidermal growth factor receptor (EGFR), as it is overexpressed in ~80% of TNBC. Yet, giving the long-standing availability of clinically approved EGFR-targeted therapies, such as lapatinib, the clinical benefit of single agent therapy is unsatisfactory, owing to the compensatory dysregulated signaling pathways. In our ongoing ERC – Advanced Grant Triple-BC (#322737) we are striving to explore combinatorial molecular targeted therapies to concomitantly block the identified dysregulated signaling pathways. Our preliminary work revealed that an inhibitor targeting cyclin-dependent kinase 9 (CDK9) strikingly synergized with targeting EGFR receptor family signaling to inhibit cell proliferation of TNBC cell lines. The overall goal of this PoC project is to exploit this novel finding and provide proof-of-concept evidence that stalling CDK9 signaling may enable successful targeted combination therapy in TNBC. Therefore, the specific objective is to assess the pharmacological response of dual EGFR-CDK9 targeting in TNBC patient-derived xenograft (PDX) mouse models in vivo. We envisage that this PoC project will translate our identified successful synergistic treatment into a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Enhancing the Research Potential of the NCSR “Demokritos” Environmental Research Laboratory in the European, National and Regional Research Areas' (PERL).

assistant: **Concept**

PERL addresses the FP7-REGPOT-1 call to improve the research potential of the Environmental Research Laboratory (EREL) of the National Centre for Scientific Research “Demokritos”, Region of Attica, Greece, in the fields of air pollution and hydrogen technologies. The Laboratory has achieved over the last years significant progress and growth but needs further support to undertake the required leap forward and evolve to a major R&D center.  The present proposal consists of a set of coherent activities, which arise from the implementation of the EREL Action Plan, directly aiming at strengthening the research capacity of the Laboratory for successful participation in research activities at European, National and Regional level. The proposed action will be built on three solid pillars: • Research infrastructures, which includes the recruitment of expert scientific personnel, modernization of existing unique facilities and acquisition of new equipment • Strategic partnership and collaboration between EREL, renowned research entities and the industry, in key thematic priorities of the ERA and National Research Activities • Outreaching of the EREL scientific achievements and research capacities as a means of increasing visibility of the work and expanding R&D collaboration. The proposal embraces networking activities with regard to research, innovation and technology with other “excellent” research institutions in EU. Emphasis is placed on achieving strategic partnerships and establishing research staff mobility with entities from regions facing similar R&D challenges thus enhancing the European, National and regional impact of EREL activities. The successful outcome of PERL will contribute essentially towards integrating the R&D activities of EREL in the general framework of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Remodelling pectin structure in plants' to be submitted under Fourth Framework.

assistant: **Abstract**

Our primary objective is to prepare transgenic plants, using potato as a model crop, with modified composition or structure of pectic polysaccharides of the cell wall. These transgenic plants will allow us to investigate the relationship between synthesis and turn-over of pectins, and cell growth and development. Also, the project aims to control functional properties (gelling ability and water binding capacity) of cell wall derived material, e.g. pectin obtained from pulp, and to control functional properties of the intact plant product such as shelf life or processing characteristics. Focussing on the model plant, potato, genes encoding enzymes involved in turn-over of galactans, arabinans and rhamnogalacturonans will be utilized for preparing the transgenic plants. Genes from potato will be used in an antisense approach for suppressing activities in potato tubers as they grow and mature. Fungal genes (from Aspergillus), already cloned by one of the partners, will be expressed in potato to modify wall structure at specific stages of tuber development. Attempts will be made to identify genes involved in rhamnogalacturonan side chain biosynthesis. Success in this area will bring full control of pectin structure within reach and will mark a major breakthrough in plant biology and biotechnology as no such genes have been cloned from plants so far. The technologies to be developed in the project will bring the following technical benefits within reach: To be able to tailor pectic polymers to meet specific quality characteristics defined by the food industry, and to valorize low-value by-products such as pulp from starch processing. Whilst potato serves as a model to obtain new insight in the effect of imposed changes in pectin metabolism and the role of endogenous pectin-r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'European Science Festival' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

The objective of the project is to enhance the European value of the Genova Science Festival, the second edition of which will be held from 28 October to 8 November 2004, in connection with the European Week of Science and Technology, 2004" and "Genova 2004: European City of Culture". The actions of this project will be mainly carried out in the following three directions: 1. Importing exhibits and contributions from European Science centres/museums/institutions that are traditionally active in science diffusion/popularisation towards society at large. 2. Organising an International Training Centre in Genova, where expert science communicators coming from different European Countries can share their expertise and experience and, at the same time, train new potential communicators on how to effectively communicate science. 3. Establishing a European collaboration network among different Science Centres and Museums to organise didactic laboratories and workshops where young visitors (pupils aged 10 to 16 years old), family groups, school classes and teachers will be taken along training paths on specific scientific topics (e.g. "Earth Science", "Microbes", "Palaeontology"). These initiatives are intended to build a close connection between research, training and communication, with public awareness as the centre of gravity, in the cultural framework of a city with an ancient history and traditionally devoted to art, science, technology and shared sociability. In this respect, the very aim of this project is to contribute to the integration of science in society and society in science at a European level. Strategic objectives addressed 1. to improve public awareness on science and its benefits and limits 2. to improve the exchange of experiences and resources in science co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tool Suite for Environmental and Economic Aviation Modelling for Policy Analysis', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

A large set of policy issues in the field of aviation and environment is discussed in ICAO/CAEP and on European level. Currently, the most urgent requirements are the capability of modelling noise, NOx stringencies and greenhouse gases in relation to the Kyoto protocol as well as related agreements together with their respective effects. Careful analysis of the complex interdependencies between air transport activities and environmental or economic effects is needed for the assessment of policies and guidance on a political level.Thus, integrated modelling capabilities have to be enhanced. In the US, this modelling capability is currently being developed in a multi-million dollar project based upon criteria, assumptions and points of view primarily set by the US. TEAM_Play will create a modelling framework to combine and advance European modelling capabilities in order to support the European perspective in the international policy arena.TEAM_Play deals with interdependencies and trade-offs between noise, gas emissions, environmental and economic impacts of the air transport sector. The objective of TEAM_Play is to enhance the European modelling capabilities required for policy assessment. These capabilities will be strengthened by creating a common infrastructure allowing for the connection of existing European models (noise, gas emissions, economic and environmental impacts).This is addressed in WP1 by linking the models to a data warehouse in which all required modelling input and output data are stored.WP2 covers the development of model interfaces which will enable the models to be connected. In addition, an economic impact assessment will be conducted. In WP3, assessment studies using the TEAM_Play Tool Suit will be carried out. In WP4, the dissemination will be c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Erosion on ship propellers and rudders - the influence of cavitation on material damages (EROCAV)', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Cavitations in fluids can cause erosion resulting in severe material damages of propellers and rudders. This may lead to loss of efficiency and even in a total loss of propeller blades. Erosion induced by cavitations can be predicted only by using engineering methods, because the physical process behind is only partly understood. Therefore a scientifically based method to predict erosion induced by cavitations is needed. The main aim of the work is to develop a practical tool to assess the risk of erosion on ship propellers and rudders. Prediction methods (the experimental and theoretical ones) that allow a quantitative full-scale erosion prediction shall be developed. The deliverables will be tested experimental methods and an analytical code to predict cavitations induced erosion. Design guidelines to minimize the risk shall be developed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Understanding the Long-Term fate of geologically stored CO2' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

ULTimateCO2 will 1) significantly advance our knowledge of specific processes that could influence the long-term (LT) fate of geologically stored CO2 and 2) yield validated tools for predicting LT storage site performance. The 4-year collaborative programme will cover detailed lab, field and modelling studies of the main physical & chemical processes involved and their impacts in the LT: a) trapping mechanisms in the reservoir (structural, dissolution, residual, mineral), b) fluid-rock interactions and effects on mechanical integrity of fractured caprock and faulted systems and c) leakage due to mechanical & chemical damage in the well vicinity. Integration of the results will enable an assessment of overall LT behaviour of storage sites at regional scale in terms of efficiency & security, also including other important aspects, e.g. far-field brine displacement and fluid mixing.The LT prediction of CO2 evolution during geological storage will thus become more robust, not only by addressing the uncertainty associated with numerical modelling, but also by applying realistic contexts and scales. The latter will be ensured through close collaboration with at least two demonstration sites in deep saline sandstone formations: the onshore NER300 Ouest Lorraine candidate in France (ArcelorMittal GeoLorraine) and the offshore EEPR Hatfield site in UK (National Grid).ULTimateCO2 will develop recommendations for operators and regulators to enable a robust demonstration of the assessment of LT storage site performance. Scientific knowledge on the LT efficiency and safety of CO2 storage will be disseminated widely to a broad audience, so that not only operators of demo sites will benefit, but also other stakeholder groups, including policy makers and regulators, storage developers,