RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Modelling of thermal runaway propagation in lithium-ion battery packs'.

assistant: **Concept**

Lithium-ion batteries (LIBs) are widely used in many applications, such as the customer electronics, electrifying transport and energy storage systems. However, despite endeavour and progresses, the number of incidents and recalls related to LIBs are far rising. Abuse operations can result in heat accumulation and consequent thermal reactions inducing failure and thermal runaway (TR), followed by fires and explosions. The TR of one single cell in a pack can trigger a reactions chain in adjacent cells. As a result, TR propagation will occur in the battery packs. The TR propagation initializing from single cell companied with the reactions chain can activate the TR of entire LIB packs and surroundings, resulting in catastrophic fire and explosion incidents. The proposed research aims to develop and validate a predictive tool for TR propagation in LIB packs based on LibFOAM the single cell TR model developed by the host and FireFOAM, the fire simulation solver of open source CFD code OpenFOAM. The following specific research objectives are set towards achieving this goal: ⁃Calibrate LibFOAM for predicting the onset of TR in a single cell under different failure modes and establish the key influencing parameters; ⁃Extend LibFOAM by coupling it with FireFOAM to predict the release of gases prior to and fol-lowing TR initiation in the triggering cell as well as the subsequent ignition and combustion of the released gases to obtain the resulting thermal environment within the cell groups;⁃Further extend LibFOAM to predict TR propagation in battery modules and packs; ⁃Validated the extended LibFOAM with experimental data in the literature and data to be generat-ed by the ER’s home institution as well as proprietary data from the UK Health and Safety Exec-utive (HSE) in an ongoi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Analysis of Dynamics and Amorphization of Metal oxides (MOx)' to be submitted under Horizon Europe.

assistant: **Abstract**

The ADAMox project, “Analysis of Dynamics and Amorphization of Metal Oxides (MOx),” addresses a critical need in catalysis, particularly for the shift from traditional fossil fuels to clean and renewable energy sources, aligning with the European Green Deal’s sustainability goals. MOx catalysts play a central role in these chemical transformations, but their structural complexity poses challenges in designing efficient catalysts. Therefore, ADAMox leverages advanced computational methods to explore the structural dynamics of MOx catalysts during operando conditions. This project aims to uncover vital structure-activity relationships, offering theoretical guidance to advance high-performance catalysts. Key objectives include understanding the formation of disordered/amorphous ensembles on MOx surfaces, exploring structure-activity relationships in catalytic reactions, and developing a universal operando simulation workflow for thermos/electro-chemical catalytic systems.The interdisciplinary approach integrates computational chemistry, machine learning, and experimental techniques, enhancing the fundamental understanding of heterogenous catalysis. Furthermore, this project adheres to open science practices, ensuring transparency and collaboration within the scientific community. For the researcher, Dr. Li, under the guidance of Prof. Núria López at ICIQ, this project offers her a unique scientific career development opportunity to excel in a traditionally male-dominated area. It provides a platform to contribute to groundbreaking research while championing openness and diversity in science.In summary, ADAMox advances catalysis for clean energy and sustainable processes, offering exciting career prospects for the researcher while promoting open science and gender diversity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Oralis, The first oral human insulin treatment for Type 2 Diabetes Mellitus' (Oralis).

assistant: **Innovation**

Type 2 Diabetes Mellitus (T2DM) affects 415M people globally, 49M of them within Europe. Caring for these individuals costs Europe €181M billion annually. However, more needs to be done as T2DM and its related co-morbidities claim hundreds of thousands of lives each year in the region. The early control of blood glucose levels (BGL) is the key to the prevention of the disease, and longer lifespans with better prognosis and higher quality of life for T2DM patients. The last century has seen considerable development in T2DM treatment, but the eventual solution to control BGL for many patients are multiple daily insulin injections. This has created a huge global market to be worth €49 billion (est. 2020). The pain, social stigma, and burden associated with injecting insulin contribute to a non-adherence to treatment that has been estimated to be as high as 61%, at a cost 9,649€ per patient per year. Oramed Pharmaceuticals (Oramed) will transform this paradigm with its POD™ technology. It protects protein therapies like insulin from the harsh conditions in the gastrointestinal tract, allowing then to be taken orally. This opens a way into oral insulin treatment to overcome many of the issues contributing to non-adherence of injected insulin treatment in T2DM patients. Using POD™ technology Oramed has produced the first oral insulin and demonstrated its efficacy in Phase II clinical trials with >300 patients and >5000 doses. We have proven oralis capability to deliver to the liver bioavailable insulin at sufficient concentration to produce significant glucose control in all glycaemic parameters in T2DM patients. Through the SME instrument Oramed will finalise the Phase III clinical trial to confirm the efficacy of oralis for glycaemic control in T2DM patients. We have alread
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Deciphering the roles of chromatin modifiers in germline aging' (Egg-Juvenate) under Horizon 2020.

assistant: **Objectives**

Faithful transfer of genetic material is critical for the success of all cell divisions. Yet, as the organism ages this process becomes more error-prone, leading to aneuploidic daughter cells due to mis-segregation of chromosomes. This can lead to cancer in mitotic cells, and in the female germline it leads to reduced fertility and exponential increase in miscarriages and birth defects already at the third decade of life. In humans, all the oocytes begin their development in-utero but arrest for decades in the middle of this process leading to the rapid increase in meiotic divisions failure. The oocytes arrest while undergoing dramatic structural changes, termed chromosome remodelling. Very little is known about what drives this critical phase in germline development, yet it is assumed to involve chromatin modifiers and DNA binding complexes. I propose to identify chromatin-modifying complexes that act in chromosome remodelling and find their mechanism of operation. This will be achieved by utilizing my recently developed technologies and RNAi screen results, which gives me unique tools and approaches to study this complex process. This research will open the window into the connection between chromatin modifiers that facilitate chromosome restructuring and germline aging. The research is aimed to find the major players in this processes and their mode of operation. In an age where maternal age is rising in the western world, translational implementation of this research would have a dramatic impact on our scientific understanding of fertility.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Identification and selective targeting of neuronal networks underlying memory', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Among the most fundamental questions in modern biology is how we learn and remember.  Using novel genetic tools, we can now ask fundamental questions not previously possible about how the brain encodes memories.  For instance, how many neurons are required for learning?  Are the network requirements similar in different brain regions?  And, probably most intriguingly, how is a neuron that is part of a memory trace different from its neighboring neurons?  In other words, what is the cellular and molecular basis of a memory?Using Pavlovian fear conditioning, decades of elegant experiments have mapped the anatomical location of the engram for learned fear.  However, at the cellular and molecular level, little is known about the physiology of individual neurons that encode a memory. Our recent results suggest a path forward, using novel genetic tools in mice that permit targeted manipulations of genes with both spatial and temporal-specificity.  In particular, using genetic manipulations of proteins absolutely required for associative learning, we now have the potential to restrict the network space in which neuronal plasticity can occur, permitting the characterization of individual neurons responsible for encoding a specific memory.Our experiments will focus on understanding the fundamental rules by which memories are organized within the brain.  Specifically, we will use the immediate-early gene Arc to map neurons active during fear conditioning at single-cell resolution. Next, we plan to define the minimum neural network requirements for establishing a fear memory.  Finally, we will investigate the learning-related changes in molecular, structural, and systems-level plasticity of individual neurons of the memory trace.Importantly, the results of these studies will not o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Regions and (E)DIHs alliance for AI-at-the-Edge adoption by European Industry 5.0 Manufacturing SMEs' under Horizon Europe.

assistant: **Concept**

The I4MS program in H2020 has been and is a great success for the Digital Transformation of European Manufacturing SMEs. Phase IV of the program was focussing on DIHs and on highly innovative technologies like Digital Twins and AI. In particular, the AI REGIO Innovation Action developed a virtuous alliance between Regions, DIHs, AI solution providers and Manufacturing SMEs, which is materialised by a new methodology for DIHs service portfolio and customer journey analysis, an AI4EU -oriented toolkit of Data and AI resources, a network of Didactic Factories and their TEchnology and REgulatory SAndboxes (TERESA) and an ecosystem of SME-driven experiments and their Digital Transformation pathways. It is time now to align such important outcomes to the evolution of Manufacturing towards Industry 5.0, the evolution of cloud AI Technologies to AI-at-the-Edge, the evolution of H2020 to Horizon and Digital Europe programmes e.g. to EDIH, Data Spaces and AI TEFs (Testing and Experimentation Facilities) for Manufacturing. Some of the AI REGIO I4MS Phase IV motivations are now evolved: it is time for AI REDGIO 5.0 for keeping momentum of AI technologies adoption in Manufacturing SMEs. AI REDGIO 5.0 aims at renovating and extending the H2020 I4MS AI REGIO alliance between Vanguard EU regions and DIHs for a competitive AI-at-the-Edge Digital Transformation of Industry 5.0 Manufacturing SMEs. AI REGIO outcomes (methods and tools for DIHs governance and cross-DIH collaboration; Data Space and AI for Manufacturing toolkit; Didactic Factories network and TERESA facilities; SME-driven  experimentations in 14 Vanguard regions) will be i) extended to the I5.0 principles; ii) enabled by the newest trusted technologies along the edge-to-cloud continuum; iii) supported by European open source
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Structure, Function and Regulation of Antimicrobial and Virulent Amyloids at High-resolution' (FuncAmyloid) targeting Horizon Europe.

assistant: **Abstract**

Self-assembly of proteins and peptides into amyloid fibrils produced across kingdoms of life is associated with antimicrobial activity, microbial pathogenicity, and a wide range of diseases. The correlation of fibrillation and morphology to function is poorly understood, and high-resolution structural information and mechanistic models are lacking. Our lab pioneered the atomic-level analysis of bacterial amyloids and eukaryotic functional fibrils involved in cytotoxicity, biofilm structuring, and antibacterial activity. We revealed novel morphologies extending beyond canonical amyloid cross- structures of tightly mated -sheets, to include, for example, cross- fibrils composed on amphipathic -helices. In addition, we exposed a unique lipid-induced cross-/ secondary structure switch in fibrils of the same sequence. Here we investigate amyloid fibrils which serve as key virulence determinants in S. aureus and Pseudomonas acting as cytotoxins and in biofilm scaffolding, and as antimicrobials produced across different species. We will leverage the knowledge and expertise, and newly emerging methods in electron, light and force microscopy, to understand how fibrillation propensity, fibril morphology and structural switches are connected to function, membrane interactions and toxicity mechanisms at high resolution. The findings are expected to identify structural features that underlie the formation, regulation, and activity of these fibrils, providing advantages in specific environments. Understanding these structure-function relationships will help to clarify the link between amyloid formation and antimicrobial activity. We will use the insights gained from these studies for the rational design of antimicrobial peptides and small molecules targeting virulent determinants tow
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Energy-Efficient Activated Sludge Monitoring for Wastewater Treatment Plants'.

assistant: **Innovation**

The aeration of activated sludge accounts for 60% of the running cost of wastewater treatment plants, a staggering 2% of all electricity generated at country-level. The project will improve upon an existing prototype of on-line microbial respirometer with near real-time capability for monitoring the activity of the microbial population (biomass) in activated sludge, and suitable for industrial and municipal wastewater applications, with the following environmental and financial benefits:• 20% reduction of greenhouse gas emission related to the aeration process (lower energy consumption)• 5% reduction of nitrous oxide emission related to the denitrification process (better process parameters)• 25 % reduction of energy costs and maintenance costs (better online monitoring of the process)The solution reduces the costs and improves the reliability of the measurements, allowing small and midsize WWTPs to monitor the biological activity of the process. The integration with existing hardware sensors and SCADA systems, allows the system to control the plant automatically within design operating parameters and reacting in real-time to variable (diurnal and seasonal) loading or toxic events. The cloud-based implementation creates a central data repository accessible for operational purposes (remote access, alerts) and management purposes (benchmarking, continuous improvement, and design of new installations). The original prototype (TRL6) was tested in Anglian Water’s Milton (Cambridge) wastewater treatment plant and gave operators information about the status of the active component (biomass) so that manual interventions could be made to improve efficiency. The project aims to take the technology forward, automate the process to a higher degree and demonstrate the solution in a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Sifting through the 3D Genome: Computational Models of Homology Search in DNA Repair' (3DGenomeSearch) targeting Horizon Europe.

assistant: **Abstract**

Homology-directed repair is an essential, evolutionary conserved DNA repair pathway that accurately restores genetic information lost due to double-stranded breaks. Its key step is the homology search, where the broken DNA end locates its matching sequence, typically located on a sister chromatid, to use as a repair template. Despite its significance, the biophysical mechanism of this search within the complex environment of vertebrate genomes remains debated. Emerging hypotheses propose that this search is driven by nucleoprotein filaments comprised of repair proteins bound to the broken DNA ends, that actively traverse the nuclear space to find and recognize homologous sequences. We will explore this mechanism by developing quantitative biophysical models that integrate the latest experimental insights on the 3D architecture of sister chromatids and dynamics of nucleoprotein filaments. Our specific aims are: (1) Model the homology search in 3D to understand how broken DNA sites navigate the complex nuclear environment and identify homologous sequences on intricately folded vertebrate sister chromatids. (2) Explore the microscopic mechanisms that drive the large-scale motions and efficient homology search by nucleoprotein filaments. (3) Understand the role of filament-driven homology search in the pairing of homologous chromosomes during meiosis. By integrating these complementary aims, we will build a detailed biophysical, mechanistic picture of homology search. We will calibrate our models against genomic and microscopic datasets, and test their predictions in collaborations with several experimental biology groups. This modeling will provide mechanistic insights into homology search, rigorously test long-standing hypotheses, and generate predictions to guide future
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Dance of galaxies: testing General Relativity and alternatives using galaxy velocity fields' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

We propose to use information encoded in peculiar velocity statistics of galaxies in the Local Universe as well as observed redshift space distortions (RSD) of distant galaxies for rendering new and very precise constraints on the validity of General Relativity (GR) and competing theories of modified gravity (MG) on cosmological and intergalactic scales.The main objectives and deliverables of our proposed research programme are:-To obtain precise modeling of both GR and MOG signatures in galaxy velocity field;-To develop self-consistent models of RSD for a wide class of MOG models;-To study the systematic impact of baryonic physics on velocity and clustering observables;-To perform a robust comparison of the predicted and observed velocity and RSD signal;-To compare cosmological parameters estimated using separately both methods;We plan to conduct our studies on GR and MG by developing methods proposed by us in previous works. For this goal it is necessary to develop a self-consistent RSD theory for MG. We will put emphasis here on the construction of theoretical models for anisotropic 2-point statistics, that will in a precise way model relations between theoretical quantities and observed ones. As a complementary probe and an important consistency test we plan to model and measure from observations 2-point correlation statistics of radial components of galaxy peculiar velocities. Our project, aimed at using galaxy velocities to test GR and MG theories on cosmological scales, will produce significant and crucial research deliverables that are necessary to fully exploit the new possibilities that the rapidly approaching era of big cosmological data will offer.