RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Structure-based drug discovery. Structural biology of wild-type & mutant fibroblast growth factor receptors' (1994-1998).

assistant: **Innovation**

Drug discovery in the pharmaceutical industry is increasingly dependent on knowledge of the three-dimensional structures of macromolecular targets. On some occasions the three-dimensional structure of a target protein may be available from Xray analysis or NMR structure determination However, drug targets are usually first identified in terms of their sequence, often through the increasing efforts in human genome sequencing in academia and industry. For the period when only the sequence of the target is available, methods of comparative modelling are of major importance. Many groups have developed algorithms for comparative modelling which depends on knowledge of the three-dimensional structure of a homologue, or even a distantly related member of a protein superfamily. Examples of this at Birkbeck include the development of anti-hypertensives through the design of inhibitors of human renin; the human renin model was constructed in 1983 (Blundell et al. 1983 Nature 304: 273-275) and used in the pharmaceutical industry for eight or nine years before the X-ray structure was determined (Dhanaraj, Blundell et al. 1992 Nature 357: 466-472). A further example is HIV proteinase which was modelled on a more distant superfamily relationship and used in drug discovery before its structure was determined in the Wlodawer laboratory in the US and in the Blundell laboratory at Birkbeck several years later in 1989. The research programme will begin by using modelling software developed at Birkbeck in Professor Blundell's group, including COMPOSER (Sutcliffe et al 1987 Protein Engineering 1:377-384) and MODELLER (Sail & Blundell 1993 Journal of Molecular Biology 243: 779-815). We will then extend their application to modelling inhibitors and substrate, by developing a framework of the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Harnessing the power of enzymatic oxygen activation'.

assistant: **Concept**

For the selective and effective incorporation of oxygen into biological molecules (oxygenation reaction), several enzyme types have evolved in nature. They catalyse crucial reactions in various metabolic routes. The chemistry feasible with these biocatalysts is unrivalled when compared with conventional chemical methods. Therefore, these oxygenating enzymes are very promising tools in biotechnological approaches. However, when compared with other enzyme classes, such as hydrolases, oxygenases are still in their infancy considering their biotechnological potential. To fully exploit the catalytic power of oxygenases, several hurdles have to be taken for which a higher level of knowledge on these enzymes is needed while also technical aspects have to be solved.The European Training Network (ETN) OXYTRAIN is a joint academic/non-academic training initiative supporting the convergence of biochemistry, enzyme engineering and biotechnology. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early stage researchers (ESRs) to satisfy the need for knowledge and skills to produce and apply oxidative enzymes. This will be achieved by setting up a network and intersectoral programme in which multiple disciplines will be integrated and exploited. By bringing together 7 academic beneficiaries that are experts in the field of individual oxygenase groups, the network will provide perfect conditions for cross-fertilization of knowledge, while the 3 industrial beneficiaries and 5 partner organisations will add to the consortium by translating the generated knowledge into real industrial applications, such as textiles, pharmaceuticals and biorefineries.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Fair Data and Innovative Services for Magnifying the Climate Adaptation potential of European Communities'.

assistant: **Innovation**

Adaptation to climate change has become a central focus for researchers across various fields, including climate science, environmental science, urban planning, information science and social science, to support policymakers in making informed decisions to build a climate-prepared and resilient society. The major challenges in achieving this goal are (i) lack of seamless interaction between platforms, data spaces, and users, (ii) poor data interoperability as well as service interoperability, (iii) lack of infrastructural support for generating FAIR data, and (iv) legal barriers hindering access to data. CLIMATE-ADAPT4EOSC aims to overcome these challenges by providing an EOSC-centred collaborative research environment equipped with existing EOSC data and services and extended with new data and services, such as Interoperability, FAIRification, Research Results Publishing as Open Data, Data Adaptation, Data Format Compliancy, Mapping and Entity Matching, enabling interoperability and seamless interaction of data that allow the creation of extended services, e.g., Big Data Analytics for climate risk assessments. The project develops a climate change adaption ontology and an EOSC Climate-Adapt Knowledge Graph based on the ontology, supporting findability, accessibility, tracking and life cycle management of research outputs of various kinds, including data, scientific papers, methods, code, software packages and tools. CLIMATE-ADAPT4EOSC also develops three innovative services that provides support to EU Mission climate change adaptation and the European Green Deal. These services have been planned to be demonstrated in Five EU countries.


**Keywords:** Climate Adaptation, Services, FAIR / Open Data, Innovative Services, Co-design
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'INnovative Training in Myeloid Regulatory Cell Therapy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Cell therapy is an active area of immunological research and represents a highly innovative and rapidly expanding sector of pharmaceutical industry. The INsTRuCT Consortium answers an unmet need in the field for postdoctoral researchers experienced in scientifically excellent research and cell therapy development. INsTRuCT draws upon complementary expertise of its academic and industrial partners to offer a unique research and training programme. INsTRuCT proposes 15 distinctive research projects based at European companies or universities recognized for their scientific achievements and innovation. INsTRuCT is structured to promote interdisciplinary and intersectoral cooperation between partners, thereby accelerating pharmaceutical development and clinical application of novel myeloid regulatory cell (MRC)-based therapies. INsTRuCT is a primarily research-based training programme, which will be complemented by theoretical and practical training opportunities.  INsTRuCT will encourage a translational view of research, which will be reinforced by intersectoral secondments. Teaching transferrable and communication skills is a high priority for INsTRuCT. ESR will gain a comprehensive overview of the drug development process in Europe as it applies to cell-based therapies; hence, INsTRuCT’s graduates will be fitted for future roles as innovative leaders in the field. INsTRuCT will strengthen interactions between cooperating research groups at junior and senior levels, thereby promoting dissemination of standardized research approaches and data-sharing. Overall, INsTRuCT constitutes an original research and training concept that responds to the specific needs of a growing sector for postdoctoral scientists trained in Basic Immunology and cell therapy development. Consequentl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Workshop on the need of in vitro toxicity tests within the pharmaceutical industru' (INVITOPHARMA).

assistant: **Innovation**

A dialog between the stakeholders within the area of pharmaceutical toxicity testing is crucial to achieve a more general use of alternative toxicity tests. More efficient toxicity tests is also an important factor to make it possible for the European pharmaceutical industry to increase its competitiveness. The increasing amount of substances passing the drug development process need to be tested with efficient methods as early as possible in the process to new pharmaceuticals. That demands more robust and cost efficient methods, not always available today. A well planned workshop where representatives from manufacturers of toxicity tests, researchers developing new in-vitro pharmaceutical toxicity tests and the European pharmaceutical industry participate makes it possible for the stakeholders to discuss the supply and demand for in-vitro pharmaceutical toxicity tests, new and already existing.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Atmospheric Flow, Loads and pOwer for Wind energy'.

assistant: **Concept**

The objective of the FLOW project is to develop new and innovative prediction methods for production statistics and load performance of modern GW-scale and 400-metre tall offshore and onshore wind energy systems. Our project will develop more accurate methods as regards the present state of the art (SOTA) and with high confidence, thereby reducing uncertainties, increasing productivity and grid stability, lowering Levelised Cost of Energy (LCoE), while establishing an open-source knowledge hub that will benefit the entire renewable energy sector and enable joint optimization between developers and OEMs. To reach these ambitions, FLOW will improve the knowledge of atmospheric flow physics and the interplay between wind farm (microscale) and large-scale (mesoscale) processes such as: wind farm global blockage, farm-farm interaction, and topographic and wake-added turbulence in complex terrain. Based on these principles, FLOW will develop and validate simulation tools that can be readily adopted by industry to lower economic uncertainties and enhance system reliability and power production, with wide economic and societal impacts. The proposed modelling framework will make extensive use of public experimental datasets to validate and train models within a FAIR data hub. The New European Wind Atlas  (NEWA) database is the foundation to grow this innovative open-source ecosystem that links experimental data, flow models, and validation datasets for benchmarking and training. Industry adoption will be facilitated through a computationally efficient modular framework that allows scalability in a production environment. FLOW’s industrial partners, comprised of VESTAS, SGRE, GE, and EDF, will verify compliance with operational processes and test the framework using private datas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Sustainable, decarbonised vanadium, titanium and iron extraction from Europe’s low-grade vanadium-bearing titanomagnetite deposits'.

assistant: **Objectives**

The EC’s Critical Raw Materials (CRM) Act sets multiple benchmarks for reducing Europe’s dependency on a few unlike-minded third countries for strategic/critical raw materials. Through the domestic extraction of two CRMs – “vanadium” (V) and “titanium metal” (Ti metal) – AVANTIS addresses the first target of the Act (> 10% domestic extraction, for V & Ti). AVANTIS’ rationale lies in the fact that Europe has a multitude of unexploited, low-grade V-bearing titanomagnetite deposits in Finland, Sweden, Greenland, Norway, Poland, Ukraine… However, these deposits have a complex “spiderweb-like” mineral assemblage. Without selective blasting, selective fragmentation and pre-concentration technologies to separate the Ti-rich ilmenite grains from the V-bearing magnetite, it is uneconomic to exploit these deposits. Supported by a bespoke forensic geometallurgy approach, AVANTIS develops a novel selective blasting approach that allows for rock excavation in view of increased mineral liberation at the blasting stage, and reduced energy demand in the crushing & grinding stages. Likewise, AVANTIS designs tailored, water-free and water-lean pre-concentration technologies that allow to produce two distinct pre-concentrates ((1) ilmenite-rich, Ti-pre-concentrate and (2) ilmenite-free, V-pre-concentrate). The water-lean method is also tailored to process V/Ti-bearing mining wastes from historical/on-going operations. The resulting flowsheets have a low net water consumption (> 70% water recycling) and reduced GHG intensity of extraction (reduction of 60–700 g CO2,eq per t ore hauled to the crushing plant). A preliminary analysis of the potential European reserves that are unlocked, yields a total of 154 Mt Ti & 3.5 Mt V (still excluding Ukraine), to be compared with current levels of EU
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Early warning of future rapid Arctic sea ice loss', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Arctic is currently transitioning toward a new climatic state that will be characterized by seasonally sea-ice-free conditions almost every year from the 2050s, with widespread ecological, climatic, and societal consequences. There is growing evidence that the future summer sea ice retreat will not occur at a constant rate. Indeed, climate model simulations are suggestive of pronounced sub-decadal fluctuations on top of the long-term trend, leading to periods of relative stability followed by abrupt sea ice decline in hardly 3-5 years. A lot remains to be understood regarding the precursors, mechanisms, predictability, and impacts of these rapid events. In particular, it is unclear how close we might be to the next one.The overall objective of this project, ArcticWATCH, is to build an integrated early warning system that alerts on the possibility of rapid Arctic sea ice loss for the following summer up to five years. This system will provide annually updated assessments and will synthesize multiple lines of evidence harvested from various data sources (pre-existing and generated during the project), including climate model projections, initialized climate model and machine-learning-based predictions, satellite observations, and climate reconstructions.By introducing innovative targeted numerical experiments, ArcticWATCH will also identify the new pathways of sea ice predictability in a warmer world and will thereby provide evidence-based guidance regarding the design of the Arctic observing system for the next 30 years. Finally, ArcticWATCH will make a leap forward in depicting environmental impacts during and after rapid sea ice loss events, from short (Arctic heatwaves and precipitation extremes) to long (interactions with the Arctic and North Atlantic oceanic cir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Does the temporal cortex make humans special? What comparing the human and great ape brain can tell us about cognitive evolution'.

assistant: **Innovation**

What makes humans the dominant animal species on the planet? Much of the popular literature has emphasized similarities between humans and our closest animal relatives, especially the chimpanzee. But there can be no doubt that humans are special. A major human cognitive specialization is our ability to process conceptual information. We are able to form abstract concepts by combining sources of information and generalizing from current knowledge. These concepts can be invoked in the absence of immediate percepts and used to recognize exemplars not encountered before (e.g., recognizing a basset hound as a dog even after only encountering beagles in the past).To understand how our brain evolved the ability to process such conceptual information, we need to know what anatomical specializations occurred to allow this behavior. We still know little, but damage to the anterior temporal lobe in humans produces disruption to the production and manipulation of abstract concepts. We also know that the anterior temporal lobe has disproportionately expanded in the humans since our divergence from old world monkeys and that its connections with other parts of the brain have proliferated.Therefore, the goal of the current proposal is to investigate which anatomical specializations have developed in the human brain, compared to that of our closest animal relatives, and whether these are involved in the uniquely human ability to process conceptual information. We will use a combination of ineuroimaging techniques to investigate the organization of the human, chimpanzee, and macaque brains to identify parts of the temporal cortex that are unique to the human brain. Then, using functional neuroimaging in the human volunteers, we will test whether this unique area is indeed activated when
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'A surface science investigation of chemical reactivity on oxyde & dispersed metal surfaces'.

assistant: **Innovation**

This project is concerned with the development of experimental techniques for preparing and characterising well-defined oxide surfaces which may then be used as substrates for fundamental studies of the surface chemistry of bulk and dispersed oxides and also for the preparation of model supported metal heterogeneous catalysts. In particular, the work will utilise the unique optical characteristics of supported epitaxial oxide layers to carry out investigations of adsorption and reaction on such surfaces by IR spectroscopy. These studies will be complemented by investigation using a range of standard surface analytical techniques (XPS, UPS, LEED, TPRS, LEIS) as well as reactive scattering measurements to evaluate the surface chemical reactivity of such systems. The studies will aim to particulary address the influence (electronic and structural) of the underlying substrate on the oxide layer's reactivity and any synergistic effects afforded by the close proximity of particulate metal and oxide surface phases.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Decoding Extracellular Vesicle-mediated organ crosstalk in vivo', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

To coordinate activities between different tissues, multicellular organisms critically rely on intercellular communication. Whereas homeostatic signalling within organs is studied extensively, inter-organ crosstalk is only starting to be unravelled. In recent years, Extracellular Vesicles (EVs) have emerged as central mediators of this pathway by shuttling specific bioactive cargo including proteins between cells. These nano-sized lipid vesicles are released by virtually every cell type, are transported via the blood and combine the intricacy of cell-cell contact with the long-acting range of cytokines. However, due to their small size and a lack of suitable approaches, to what extent endogenous EVs mediate inter-organ crosstalk and support custom cargo delivery is unclear. I recently developed a unique transparent zebrafish embryo model expressing optical EV-reporters to examine endogenous EV biology at unprecedented detail in vivo. The aim of this proposal is to understand endogenous EV-mediated organ crosstalk by studying EVs secreted by the liver, the central metabolic hub in vertebrates. To this end, I will decode hepatic EV communication routes in vivo in health and liver pathology by exploiting my model system combined with novel tools and high-resolution microscopy. I will pursue three key-objectives: 1) Targets: mapping hepatic EV target organs; 2) Contents: analysing custom cargo delivery by hepatic EVs to specific target organs. 3) Function: determining the function of endogenous hepatic EVs by developing and applying molecular tools to interfere with their release in vivo. This project will provide the first advanced mapping of endogenous EV inter-organ crosstalk in a living model organism. By studying how pathology impacts EV mediated organ crosstalk and ga