RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Boosting Lignocellulose Biomass Deconstruction with Designer Cellulosomes for Industrial Applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The major bottleneck for plant biomass processing is fiber saccharification: the conversion of cell wall lignocellulosic biomass into fermentable sugars (en route to production of value-added chemicals like second generation biofuels). Some microbes enhance this step by using natural self-assembling proteinaceous nanocatalists known as cellulosomes. CellulosomePlus targets rational design of optimized cellulosomes to overcome this problem.This would allow efficient production of biofuels from low-value raw materials like inedible parts of plants and industrial residues (which are all renewable, sustainable and inexpensive). First we propose to characterize the physicochemical and structural properties (including mechanostability) as well as interactions of enzymes and scaffolds from natural cellulosomes and non-cellulosomal components. In parallel, we will characterize a suitable residual substrate from municipal waste (organic fraction of municipal solid waste) and develop improved assays to reliably follow cellulosomal enzymatic activity. The acquired knowledge will be complemented with rapid computational modelling at the atomic and supramolecular levels for testing and predictions. Experimental and theoretical knowledge will be then integrated to design improved cellulosomes (with high-selectivity, activity and cost-effectiveness). Further improvement will be obtained by iteration using high throughput screening of components. The improved cellulosomes generated through this innovative multidisciplinary approach represent a step towards green chemistry since they are biodegradable proteinaceous materials and therefore by-products and/or wastes are minimized due to the high enzymatic selectivity. Finally, the production of the optimized cellulosomes (and the process
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Transition to Turbulence of Volumetrically Heated Flows' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Numerical techniques are proposed that can capture the transition to turbulence of shear flow and in the process they offer the capability of state of the art control of such transitions. The methods can enhance the calculation of fluid flow by identifying the hierarchical bifurcation of the evolving states. Thus, the predictive power of the underlying mathematical models is strengthened. Concurrently they offer the unique possibility of unifying the results with those obtained by techniques that are developed with the sole aim of capturing the fully developed turbulent state. The novel methods can be used to pinpoint the transition of the flow from its laminar (basic) state to its fully developed (turbulent) state. Meanwhile programmes that are designed to capture the nature of the flow at its final (turbulent) state will be benchmarked against the programmes that pinpoint its transition. Software that unifies the programmes will be able to oversee the development of the fluid flow throughout its evolution. The emerging software will run on single or shared memory (parallel) hardware, thus reducing dramatically the computational costs. It is the ultimate aim of this set of programmes to apply the resulting software to complex configurations applicable to a variety of configurations. Simple geometries will be considered at first to act as benchmarks and common ground for the two different state of the art software avenues at our disposal: the proprietary code developed at Aston University and a commercially available CFD code. We intend to use the results of our studies to be applicable to the Nuclear Industry to model regime transition in complex systems where molten metals, molten salts and water are used as the coolant.  Operating regimes of interest include the ther
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Whispering the language of the neurons to restore vision' (NeuroBaBEL) targeting Horizon 2020.

assistant: **Abstract**

Visual neuroprostheses or the bionic eyes, aim to restore patterned vision to the blind by electrically stimulating the remaining neurons in the visual system. The ultimate goal of bionic eye research as a means of treating vision loss is the capacity to reproduce the same neural messages that travel between the eye and the brain of normal vision. The visual system 'sees' the world by way of sending signals to the brain that indicate transitions from 'light ON to light OFF' and from 'light OFF to light ON' wherever a transition exists. Despite the remarkable progress over the last decade, until recently, visual neuroprostheses could only stimulate both the ‘ON-to-OFF’ and the ‘OFF-to-ON’ pathways simultaneously, sending confusing neural messages to the brain. Selective activation has been demonstrated in vitro while validated computational models predict that neural signals can be modulated by affecting these waveforms. This proposal aims to investigate, in a functional model of the disease (Royal College of Surgeons rats), new ways to preferentially activate the aforementioned visual pathways using amplitude- and frequency- modulated signals combined with low-power noise. It is expected that the resulting neural encoding to be more natural and to therefore improve the perception of the bionic eye recipients. Two strategies will be adopted: (1) acute electrophysiology experiments to obtain optimal stimulation parameters, and (2) chronic studies in behaving animals with retinal degeneration subjected to classical conditioning. This is a highly multidisciplinary proposal that includes a comprehensive plan for the dissemination of the results among the scientific community and the general public, while providing opportunities for industrial engagement. The fellow will be i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrated Single-photon Sources in Silicon' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The breakthrough field of quantum information science seeks to manipulate and control quantum mechanical phenomena to enable us to realise revolutionary technologies such as ultraprecise measurement, and quantum computing and simulation. However in the highly promising optical implementation of these technologies there is a severe limitation that hampers research: there are no scalable sources that can produce single-photons on command.The science goal of this proposal is to create a deterministic source of single-photons for applications in quantum information processing. We will develop an integrated silicon and laser-written waveguide photonic-chip platform that provides a scalable solution to the problem of single-photon generation. Modern silicon-photonic manufacturing platforms will enable us to create a photon-pair generation and wavelength filtering system in a single chip. Many of these probabilistic sources are arranged in an array so that detection, feedforward and routing can deliver single photons to an output with very high certainty. The performance of our completed source will be benchmarked in landmark quantum metrology  and measurement based computing experiments and in the future our system will find applications in commercial areas such as quantum cryptography and more fundamental fields of research such as optical quantum computing.This fellowship will enable an academic with an outstanding track record in waveguide physics and single-photon source research to join a world leading group in optical quantum science. The prospective fellow brings with them many collaborative links and 8 years of research gained in a leading Australian universities’ research consortium. This project will result in the exchange of knowledge and expertise through its inno
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Polypeptide Hybrid Nanogels for the Delivery of Agricultural Biostimulants.' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The impact of climate change on agriculture is expected to lead to significant reduction in crop yield by the abiotic stress it causes for plants. With a growing world population, this puts a serious risk on future food security. The past concept of more fertiliser, more pesticides is not sustainable anymore due to the long-lasting negative effect this might have on the environment and human health. The use of biostimulants such as natural bacteria able to promote plant health and productivity is seen as the way forward. AgriGel aims to develop a novel approach in biostimulant formulation in which the bacteria are embedded in a polypeptide hydrogel containing sugar loaded polypeptide nanoparticles. In this system, the nature-inspired degradable polypeptides and the sugar provide the nutrients (nitrogen, oxygen, carbon) for the bacteria to grow once applied to the plant. The project aims at a proof-of-concept spanning from the synthesis of the nanoparticle loaded hydrogels to in vitro assays testing the nitrogen fixation and phosphorous solubilisation of the bacteria. This innovative project is placed at the intersection of polymer chemistry, material science, microbiology and agricultural technology. With Syngenta UK the project involves a multinational agricultural company offering several months of secondment and full access to their laboratories and expertise. This intersectoral project will provide an exceptional opportunity for the validation of the materials as well as a unique experience for the applicant in industrial R&D during secondments. The applicants’ expertise will be further enhanced by a dedicated training programme in scientific and complementary skills jointly offered by the academic and industry partner for a positive career impact. Project results w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Improving water management in semi-arid regions: Insights in hydrological and environmental controls of lakes using triple oxygen isotopes'.

assistant: **Concept**

Lakes provide an important water resource for agricultural and industrial purposes, and form a critical habitat for plants and animals. Understanding the hydrological functioning of lakes is fundamental to understand hydrological feedbacks related to changing environmental conditions in the context of current climate change and also of increasing importance for environmental policy. Stable isotope ratios of water (2H/1H, 18O/16O) are widely used in lake hydrology studies, providing information on the hydrological balance of lake systems. However, in cases where the system is under-defined, a full quantitative assessment of the lake’s hydrological balance is challenging. Recent investigations have demonstrated that the additional analysis of the rare oxygen-17 isotope can provide additional quantitative information about the hydrological and environmental conditions during lake evaporation. The HydrO-17 Project will explore the potential of the triple oxygen isotope analysis (18O, 17O, 16O), expressed as 17O-excess, for quantitative hydrological balancing of lakes by examining the seasonal isotope evolution of hydrologically different lake systems in the Andalusian lowlands, Southern Spain, where agricultural overexploitation of groundwater aquifers over the last decades led to a severe water deficit. Current climate change will further intensify these problems. The results of the project will contribute to the understanding of the hydrological functioning of lake systems in Andalusia, with implications for local water management strategies. The approach has potential application to lakes in other regions in the world. The outcomes will also help to improve the interpretation of paleoclimate and paleoenvironmental information obtained from paleo-lake sediment archives.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Induced pluripotent stem cells in rabbit, pig' under Seventh Framework.

assistant: **Concept**

The ANISTEM project is aimed at creating a 4-years training and transfer of knowledge program between a Hungarian SME and a Dutch and a Hungarian University in the field of stem cell research in mammalians (rabbit, pig), which will open opportunities for a mutuallybeneficial long term partnership of veterinary and medical research and for applications between the industrial and academic participants. The scientific and industrial aim of ANISTEM is to generate new comparative information on the generation, maintenance and characteristics of induced Pluripotent Stem (iPS) cells in rabbit and pig  and on their differentiation towards the cardiac lineage. The physiology of cardiomyocytes from iPS cells from rabbit and pig will be compared and their ability to report drug responses faithfully will be investigated.The ANISTEM project links intersectorial research activities in SME and Academia in different mammalian and cellular systems. An interdisciplinary approach is needed using methods from cell biology, structural cell biology, developmental biology, molecular biology and finally bioinformatics. Training and transfer of knowledge activities are structured to ensure maximum efficiency in developing and exchanging new standards between industry and academia and to expose the participating researchers to different environments and schools of thoughts. The main impact of the project is expected to be in integrating efforts in stem cell biology, biomedical models and cell therapy between industry and academia for long term collaboration. Better stem cell differentiation protocols in mammalians will potentially allow for validation and development of iPS cells as highly desirable alternatives for live animals for drug testing, disease modeling and research on regenerative med
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy' in the context of a Horizon Europe call.

assistant: **Objectives**

The CardioSCOPE proposal aims to bring together experts from Companies and Αcademia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases. Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming “omics” era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designed secondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries: 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Smart and intuitive osseointegrated transfemoral prostheses embodying advanced dynamic behaviors' (MyLeg) under Horizon 2020.

assistant: **Objectives**

Limb loss is one of the most physically and psychologically devastating events that can happen to a person. In USA, the main causes of lower-limb amputation are vascular diseases (70%), trauma (22%), congenital or birth defects (4%), and tumors (4%). Even if with appropriate rehabilitation many people can learn to walk or function again, amputation continues to be a large problem, as there still remains a significant gap between the most advanced prosthetic devices and their anatomical counterparts. The MyLeg project aims at developing both a solid theoretical understanding and the enabling technologies for the realization of a new generation of transfemoral prostheses that can be intuitively operated, sensed, and trusted as the healthy counterpart. MyLeg introduces the concept of smart and intuitive osseointegrated transfemoral prostheses that embody advanced dynamic behaviors.The MyLeg prosthetic system will be directly anchored to the amputee’s bone by means of osseointegrated implant to enhance the human-prosthesis interaction, perception, and motion capabilities; it will include implantable myoelectric sensors on targeted reinnervated muscles to realize an intuitive EMG control and to provide a high-level of cognition abilities; it will implement variable stiffness actuators realized with stress-stiffening nanostructured materials that guarantee high adaptability with respect to different tasks, dependability, and decisional autonomy; it will exploit light-weighted nanofibrous materials for sensing and energy harvesting. As the MyLeg project aims for direct exploitation in the prosthetic market, the MyLeg prosthetic system will be evaluated with osseointegrated amputees in a wide variety of activities of daily living, with a clear focus on increased Technology Read
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Coastal monitoring and management (COAST)'.

assistant: **Innovation**

Specific ObjectivesSpecific Objectives in 2002:The overall Objective of COAST is to deliver appropriate data, information and tools to Commission Services and national/international bodies linked to monitoring and implementation of EU environmental legislation.In this context specific objectives are:- To provide spatial marine environmental data and information for the implementation and monitoring of the Nitrates Directive, the Urban Waste Water Directive and the Water Framework Directive and the implementation of Integrated Coastal Zone Management in Europe- To contribute to the EEA's work programme and environmental reporting (also through collaboration with the EEA' s European Topic Centre Water) by delivering coastal/marine data for selected thematic and geographical areas;- To support training and capacity building for sustainable management of the marine resources;- To collaborate with the Marine Regional Conventions (e.g. the Commission for the Protection of the Baltic Sea Area / Helsinki Commission) through delivering satellite derived data for the monitoring of the marine environment and joint development of assessment tools/methods;- To combine and integrate, where possible, activities in COAST and Project No. 41 (Water Quality) related to the development of methods and tools for monitoring and assessment of eutrophication;- To demonstrate and verify the applied data processing procedures.Planned DeliverablesDeliverables 2002:- Physical model data for the North Sea, monthly mean values (1982-1997) plus climatologic data set;- Physical model data for the Baltic Sea, monthly mean values (1980-1991) plus climatologic data set;- Biological model data for the Baltic Sea, monthly mean values (1980-1991) plus climatologic data set;- Scientific publication on PSA and