RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Single-molecule profiling of full-length Tau isoforms and phosphorylated proteoforms'.

assistant: **Innovation**

Abnormal post-translational modifications (PTMs) can lead to the aggregation of Tau proteins, which characterize a wide range of neurodegenerative diseases known as tauopathies. Some abnormal Tau proteins will be released into biological fluids, providing a chance for minimally- or non-invasive diagnosis. For Alzheimer's Disease (AD), site-specific phosphorylations and truncations are representative PTMs that have been proved as biomarkers for its early diagnosis and progression monitoring. To detect and quantify these abnormal Tau proteoforms, two methodologies—immunoassays and mass spectrometry (MS)—are frequently employed. However, both of them encounter significant challenges in clinical trials; immunoassays suffer from limited epitopes and false positive results, while MS involves a complicated and time-consuming workflow.Nanopore technology, distinguished by its capability of real-time single-molecule sensing, has shown great prospects in polypeptide analysis, potentially offering distinct advantages over the forementioned methods in clinical trials. Recent progress has been made to sense PTMs deep within full-length polypeptides. By leveraging the recent advances in nanopore technology and the development of numerous site-specific anti-Tau binders, this project aims to exploit a single-molecule toolkit for detecting Tau of varying lengths and clinically relevant phosphorylations across full-length Tau proteoforms. To achieve that, we will leverage engineered nanopores developed by the host lab to facilitate translocation of intact Tau proteoforms, alongside a binder-assisted strategy to amplify the signals of targeted truncations and phosphorylations while minimizing interference from non-target backgrounds. Should our goal accomplished, it could provide a sensit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Measures for behaving safely in traffic' (MeBeSafe), addressing dissemination and exploitation.

assistant: **Impact**

Navigating traffic is mostly habitual; Our behaviour neither requires a lot of elaborate conscious decision-making, nor is it purely automatic/reflexive. However, most current measures intended to get traffic users to behave safer appeal to our deliberate self (awareness campaigns, speed signs), act autonomously on our behalf (autonomous braking, traffic lights), or seek to “assist” us by presenting feedback/information (Forward Collision Warning, roadside speed displays). However, the latter category of measures is often not effective as users either switch them off or do not act on the information provided.MeBeSafe is looking to directly change our habitual traffic behaviour using “nudging”. This concept from behavioural economics relates to subconsciously stimulating us to make a desired choice, without forcing us if we want to go a different way. Nudging measures are less invasive, give the user choice (but predispose him to make a desired choice) and can be provided earlier in the chain of events leading to a critical situation.We plan to implement nudging feedback both for in-vehicle Advanced Driver Assistance Systems (ADAS, existing or close-to-market), and through roadside infrastructure (e.g. measures directed at cyclists). Currently no roadside equivalent of ADAS exists, and we will prototype and demonstrate one version.We will prospectively analyse the effectiveness of suggested nudging measures first by modelling, followed by controlled experiments. We will furthermore conduct a field trial to evaluate the long-term learning effect for one proposed nudging measure.Our consortium includes automotive OEMs and suppliers, road infrastructure and fleet owners, SME’s involved in traffic data analysis, and leading organisations in traffic safety research and modell
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Electrochemical interfacial engineering of metal organic frame work towards aluminium solid state batteries' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Aluminium solid-state rechargeable batteries are promising candidate for post-lithium ion batteries. The electrolyte system of rechargeable aluminium batteries is an urgent research problem that is preventing its widespread implementation. The prime aim of the research proposal is electrochemical interfacial engineering of metal organic frame work (MOFs) based electrolyte towards aluminium solid-state battery applications. Study of MOFs are key topic in materials science sector over the past decade for facilitating next generation nano-electronic devices. Tuning the porosity of MOF can provide controllable functionality - an ideal platform for investigating the underlying mechanism of solid-state electrolytes (SSEs) and their ion conduction and the structure property relationships. This research proposal will address the challenges in the conventional liquid electrolytes and existing SSEs. The potential impact of the project proposal are traditional liquid electrolytes and conventional inorganic SSEs can be replaced by flexible, cost-effective and high porous MOF based SSEs for high performance and environment friendly aluminium batteries. The specific research objective of the project are, O1. Facile synthesis of cost-effective and high-performance nanostructured MOFsO2.  Encapsulating an infinitesimal ionic liquid (IL) into MOFs to construct an IL@MOF solid electrolyteO3. Understanding the inherent electrochemical interface and studying the underlying structure-property relationship of IL@MOF based SSEsO4. Demonstrating a cost effective and environment friendly aluminium solid state battery with high specific power density using synthesized solid electrolyteResearch results will be published in reputed high impact open access international journals and conferences. Th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'How consciousness is shaped by neuronal network dynamics' in the context of a Horizon 2020 call.

assistant: **Objectives**

How does the structure of the brain give rise to its function? We will address this longstanding neuroscience question through an interdisciplinary research project, by using computational modelling to study the neuronal dynamics which underlies the specific brain function of consciousness. More precisely we propose to investigate the differences in neuronal dynamics between conscious and unconscious brain states, and how conscious experience is shared across subjects watching a movie. The project capitalizes on using whole brain models that are constrained by anatomical and functional connectivity data from humans and non-human primates. In a first study, we will test whether differentiation of brain activity, as indicated by homogeneity differences of functional connectivity patterns across the modelled brain areas, can serve as a marker of consciousness. In a second study we will construct a whole brain model of experiments in which subjects synchronize their brain activity when watching a natural stimulus such as a movie. Through external stimulation of the model we will determine the set of brain areas that is causally involved in driving this synchronization of conscious experience. The results will give new theoretical insights on how neuronal interactions at an entire brain’s scale are informative of consciousness and shared conscious experience across subjects.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Residential Building Energy Renovations with On-Bill Financing' (Ren-on-Bill).

assistant: **Concept**

Ren-on-Bill’s overall objective is to scale up investments towards deep energy renovations (ER) of residential buildings by promoting the development and implementation of On-Bill Financing schemes, based on the cooperation between energy utilities and financial institutions.On-Bill Financing (OBF) is a method of financing ER investments that draws on utility bills as repayment vehicle. OBF has been in use for more than 30 years, and it is especially widespread in the USA and Canada, where it significantly drives the building renovation market, with over 1 billion $ investments reached by 2013. Compared to traditional loans, default rates have been found to be lower, thus making OBF a lower risk instrument for investors. In Europe, although a few attempts have been made, OBF has not yet had a significant impact on the residential energy efficiency building renovation market.In detail, the project will:- Analyse and define the residential building ER and OBF market context to enable replication of suitable OBF schemes across Europe;- Engage key stakeholders (in particular energy utilities, financial institutions, representatives of the final user and ER market side) through national stakeholder platforms;- Develop tools to structure the residential sector’s ER financing demand allowing allows utilities and financial institutions to assess ER investments based on a transparent methodology and to bundle investments accordingly;- Develop suitable utility business models for the deployment of deep energy renovation OBF schemes for residential buildings in Europe;- Implement selected OBF business models at the 3 Ren-on-Bill partner utilities through a collaboration for strategic development of pilot on-bill financing schemes;- Exploit the insights gained over the project hori
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'From warfare to welfare: a comparative study of how combat trauma is internalized and institutionalized' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

This project is an anthropological study of combat trauma in three Western nations: Israel, the United States, and the Netherlands.  Trauma means different things to different actors, and acquires a different value (both economic and social) in different therapeutic settings.  Research will examine how clinical notions of combat trauma are established, adapted, resisted or internalized in different nations.  It will result in a comparative framework for understanding how combat trauma is shaped by two major modern institutions: the military and psychiatry.  Methodologically, it combines ethnographic fieldwork with veterans, research on clinical practices, and analysis of the policies and discourses that institutionalize combat trauma.  Unusual within trauma studies, it aims to shed light on potentially conflicting values about violence and suffering in military and psychiatric instiutions, which may be less apparent to researchers trained within those institutions.  By analyzing how veterans and clinicians perceive ethnicity, it will also contribute to understanding of the experiences of subordinate ethnic groups in military and psychiatric institutions.  It is expected to identify key problems in the delivery of good care to veterans and have an impact on policy and healthcare.  Theoretically, it will advance studies of biopolitics and medicalization.  Existing theories tend to minimize how patients contest clinical models of illness.  The moral significance of violence in combat trauma may, however, create particular kinds of resistance to clinical illness models – an issue that has not been previously addressed.  This study will make a major contribution to understanding how war related suffering is internalized and institutionalized as clinical illness.  It will als
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Disentangling the early-life environmental determinants of pediatric LIVER injury: An eXposome-wide approach', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

LIVER-X addresses an important question: how does the environment impact the developmental origins of liver health and disease?Poor liver health in childhood represents a major public health problem with long-term consequences. Elevated alanine aminotransferase, a marker of liver injury and screening tool for pediatric non-alcoholic fatty liver disease (NAFLD) risk, is increasingly reported at young ages, currently being detected in almost one out of ten children living in Europe and the western world. Although it is well known that an obesogenic diet and genetic predisposition play a role in the development of liver injury and disease, the contribution of the complex environment in which we grow up and live remains unclear. LIVER-X addresses this knowledge gap. The project will leverage the resources of the population-based HELIX and Generation R cohorts and follow an exposome-wide approach to the study of environmental impact by using rich biomonitoring and geospatial exposure data collected at the vulnerable early stages of the lifecourse (pregnancy and childhood). Advanced analysis techniques will be used to provide novel evidence on the individual and combined effects of a wide array of early-life ubiquitous environmental factors, including industrial chemical pollutants, toxic metals, air pollution, and characteristics of the urban natural and built environment, on liver injury markers in childhood and adolescence. The project will also assess whether childrens diet quality and polygenic risk for NAFLD modify vulnerability to environmental impact, and thus aid in identifying susceptible subpopulations and environmental priorities. LIVER-X fosters research cooperation across disciplines and knowledge transfer. The project aligns with urgent challenges related to en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Coupling of atmospheric layers' in the context of a Fifth Framework call.

assistant: **Objectives**

The objectives are to(a) educate young scientists in a broad range of atmospheric disciplines,(b) teach young scientists a range of scientific methods,(c) teach young scientists to collaborate across discipline boundanes,(d) develop entrepreneurial skills in young scientists,(e) teach young scientists to co-ordinate and implement larger collaborations, and(f) teach young scientists to communicate scientific result to the public.To address the questions studied with the network, scientists from a variety of fields within atmospheric sciences must work together. Specific fields include the physics of plasmas, discharges, atmospheric chemistry, electromagnetism, clouds, fluid dynamics, statistics, geophysics, and space physics. The techniques include observations and instrumentation, and PIC and GCM simulations. The network activities include an observational programme that will bring together a variety of instrumental techniques to be applied to the research topic of the network. Co-ordinated ground and space observational campaigns will have participation of the young scientists.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unique patented technology for recycling mixed plastic waste and other hard-to-recycle waste streams to REMATerialize them to valuable products' in the context of a Horizon 2020 call.

assistant: **Objectives**

WIMAO is flipping the “take, make and dispose of” model on its head with REMAT: a breakthrough process to repurpose 230 millions of tons of plastic waste that are being sent to landfills and incinerators every year. Furthermore, countries where we have been previously been exporting the majority our waste have put a ban on the import of foreign waste which means than billions of tons of waste have nowhere to go and threaten EU’s ambitious targets to recycle up to 75% of waste by 2023.Our patented recycling technology gives second life to these plastic waste streams in the form of new composite products that have the same properties as the billions of cubic meters of products manufactured every year from virgin raw materials. WIMAO is uniquely positioned to create a new standard operating mode for the recycling industry because we have the only technology versatile enough to handle the volumes of waste that Material Recovery Facilities (MRF) collect exactly as they receive it, without the need to separate waste streams, effectively surmounting the key barrier for recycling.We already have developed a proof of concept REMAT plant that started production in January 2019 turning mixed plastic waste that is not wanted by the plastic recycling industry and wood waste into composite decking tiles and half euro pallets. Now we are preparing to develop the next generation of our technology to 1) consistently process new types of plastic waste streams 2) manufacture larger and more complex composite products and 3) create automated process controls to accommodate fluctuations in waste materials. This will set the stage for licensing our technology where we expect to have 26 plants and modules diverting 168,000 tons of waste per year from landfills and generating €48.75M in turnov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Data Governance for Supporting GDPR' to be submitted under Horizon 2020.

assistant: **Abstract**

The rapid advances in ICT have raised the need to adapt to this progress for organisations (pushing them towards e-services and increase their efficiency), public authorities (stimulating new services to citizens and reducing complexity) and individuals (enabling them to communicate personal information more efficiently). DEFeND will deliver a platform which empowers organisations in different sectors to assess the compliance status, plan the achievement of the GDPR compliance and increase their maturity in different aspects of GDPR. DEFeND platform enables building and analysing models following a Privacy-by-Design approach spanning over two levels, the Planning Level and the Operational Level, and across three management areas: Data Scope, Data Process and Data Breach. The consortium will leverage existing software, tools and methodologies towards the implementation of the platform software components. The DEFeND platform will be tested in living labs pilots, involving partners from four E.U. countries in four different areas: healthcare, banks, energy and local public administration. It will be tested in an operational environment (TRL 7) in three different scenarios across two different types, focusing on the GDPR compliance process for end-users and on the GDPR implications for external stakeholders. Driven by the lack of appropriate products in the market, the DEFeND exploitation strategy is based on commercialisation of project results at three levels: platform-as-a-whole, fragments of the platform and partners’ individual exploitation. This strategy will enable partners to integrate the results into their existing commercial offerings, exploring and establishing new business opportunities. The exploitation strategy will focus on four areas: Sector Specific Explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Intercellular signalling through connexin channels : a key to the understanding of cardiovascular research' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

The consortium project is to investigate the role of connexins in the physio(patho)logy of heart and vessels , and their involvment in the early pathogenesis of major cardiovascular disease, by an experimental approach to which aim European teams will contribute. One of the essential pathways of the intercellula signalling network which underlies the functions of all the tissues is the cell to cell coupling by means of specialized menbrane channels composed of connexins. In the diverse tissues of the cardiovascular system the cells are connected by these channels which mediate signals controlling functions as,distinct as,e.g. the coordinated contraction of myocytes or smooth muscle cells or migration and growth of endothelial cells . Dysregulation of the connexin channels interferes with the functions of the cardiovascular system : conversely chronic alteration of these functions (e.g fibrillation,hypertension) induces cells-specific changes in connexin expression elther in heart or in vascular wall.