RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Bridging the gap between INnovative entreprises and financial inVEstors in the emerging ICT markets of SaTellite applications'.

assistant: **Objectives**

In the ICT sector, whether in the USA, Japan, or Europe, innovative services are already in use, based on large scale space-based investments: they involve earth observation, telecommunication, navigation, timing and positioning satellites. In combination with the advent of powerful handheld terminals and the demand for ubiquitous services, it is expected that info-mobility applications will reveal new sources of business in the years ahead, using particularly the EGNOS and future GALILEO systems.Hence, such satellite-based capabilities must be seen as incomparable, new and unique opportunities for Europe to enhance economic development in the ICT-based knowledge economy. This growth potential has already been grasped by many incubating structures in Europe. Yet, the actual business growth rate appears below expectations. Europe must overcome intrinsic innovation financing barriers to seize these new business opportunities faster and with more economic impacts.Several members of the ESINET network have joined under the leadership of EBN to find solutions in order to characterize and remove these barriers in a coordinated way. Specific and generic features of the barriers to innovation financing will be addressed, allowing consolidate and disseminate the knowledge components that are required to support more investments into such innovative ICT-intensive services. Good practices and guidance materials for entrepreneurs, innovative enterprises, incubators or investors, will then be developed and validated 'in vivo'.Specific workshops will further validate and disseminate the obtained results towards key stakeholders. Policy lessons will be proposed regarding public/private partnerships able to increase the business prospects of satellite capabilities. In order to meet suc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Identification and functional validation of drugable targets/pathways for triple negative breast cancer'.

assistant: **Objectives**

Patients suffering from triple-negative breast cancer (TNBC) have a poor prognosis as these tumors frequently confer resistance against chemotherapeutic agents and lack drug targets such as estrogen receptor, progesterone receptor, and epidermal growth factor receptor 2. Insufficient knowledge on the biology of this specific breast tumor type and its heterogeneity  hinder the identification of potential novel drug targets. Lethality enhancer screening is an ideal approach to identify new drug targets in tumors with specific genetic aberrations. We plan to adapt this concept of synthetic lethality by anticipating that while TNBC cells confer resistance to available anticancer drugs, specific knock down of particular genes by RNA-interference (RNAi) may result in a synergistic cell killing. Another important aspect of our approach is that we will concentrate in our screens on the top 500 candidate genes shown to be crucial in TNBC for cellular processes. The genes will be prioritized by Bayesian network analysis on prior knowledge on clinical TNBC from our own extensive genomics and proteomics studies, the literature, next generation sequencing efforts, and databases listing drugability of targets. We will employ RNAi-based knock down of drugable targets in 22 cell lines to reveal genes essential for drug resistance in TNBC. In addition to 2D cultures, screens will also be applied to 3D cultures, which are thought to better reflect the in vivo situation. The most effective combinations for each TNBC subtype will further be functionally investigated in vitro and in vivo to unravel the molecular nature of the synthetic lethality. Finally, translational studies will be performed to establish the potential clinical relevance of the identified targets/pathways in large numbers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'On Trade Policies and Climate Change' (TradePoliciesClimate) under Horizon 2020.

assistant: **Objectives**

Climate Change and Trade are two examples of public goods that call for international cooperation and coordination. The threats due to changes in climate conditions and the losses potentially due to adverse (or extreme) weather events have induced countries to look for common solutions. Moreover, trade and climate change are not only two global scale issues, but they are also tightly connected: trade is a major economic activity, climate is a major exogenous factor in economic production. Trade and climate change have direct and indirect links: trade impacts climate either through the emissions of the transport industry, and by favoring (or disfavoring) emissions-saving productions; climate change directly impacts trade by modifying comparative advantages, and indirectly by legitimating trade as an adaptation strategy. Trade is fostered by trade policies, which are also tightly connected to the dynamics of climate change. Thus, environmental and trade policies tend to be connected, and research to deepen on these links would be beneficial.The proposed research aims at investigating how climate change influences trade (volumes, values, and patterns) and how trade policies are evolving and are likely to evolve due to climate change. The research will focus on the effects of climate change on trade and trade policies. More precisely, the project intends to achieve the following two goals: (i) analyse the links between, trade and climate change, and quantify the impacts; (ii) investigate the path dependencies in trade, trade regulations and climate change, so to evaluate co-benefits and side-effects of seemingly unrelated policies on climate change and trade.The methodological approach that I will follow stands out against previously adopted methods. I propose an econometri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Regular update of seismic hazard maps through thermal space observations' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

SISMOSAT is a proposal airned to develop a pre-operational system from EO information to improve the present elaboration process of seismic hazard maps and their further use, testing their cost-effectiveness for a limited period in a realistic operational context. The application represents an innovative use of satellite information very new for the customers involved that could modifies their existing production process. The proposal is not oriented to seismic risk area 2.3.2. because it is not aimed directly to the study of genetic aspects from earthquakes, the laws that governs the production of quakes or the validation of any proposed models for their occurrence It deals with the introduction of space observations from already known geophysical parameters related to sismogenetic zones, into the internal procedures of entities with a legal mandate to operate under such potential hazard Thus the project is promoting the transfer of spacebome suitable data to real customers The proposal innovative aspects comes from the introduction of space inforrnation into the routine process of concrete organizations Consequently the structure of the proposed work follows a customer oriented approach with a final evaluation phase that includes assessment of cost and benefits that will influence the fmal long term operational adoption of the tested approach.  The main objectives are:  1. To introduce information from satellite observations in the process of elaboration of seismic hazard maps 2. To improve the present information of organizations that uses seismic hazard maps to prepare action plans for the safety of citizens, the prevention of material damages and the insurance of potential damages  The project is based in an innovative thermal space observation approach, for which
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Global analysis of DNA-protein interactions by sensitive proximity-dependent DNA ligation assays and tag arrays' (2002-2006).

assistant: **Concept**

Proteins interact with genomic DNA to bring the genome to life. The precise regulation of numerous genes is required to maintain normal cellular proliferation and differentiation. A key step in the regulation of networks that control gene expression is the sequence-specific binding of transcription factors to their DNA recognition sites, and sequence-specific DNA binding by proteins even controls recombination, restriction, and replication. Understanding where regulatory proteins bind to the genome in vivo is critical to understanding the mechanism and logic of these essential processes. Available methods to determine sequence requirements suffer from either insufficient specificity, sensitivity or a limited potential for multiplexed analysis.Therefore, I w ill develop a highly parallel and sensitive method for studying the sequence specificity of DNA-protein interactions. My approach will be based on the sensitive proximity ligation assay developed in my host laboratory and will include a multiplexed readout using tag arrays. This technique will allow functional analysis of DNA binding proteins at an unprecedented scale and with the potential to analyse even individual cells, providing a unique perspective on gene regulation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Hearts and limbs: Linking morphometrics with 3D analysis of gene expression patterns' in the context of a Seventh Framework call.

assistant: **Objectives**

Development of new imaging techniques, such as optical projection tomography (OPT), to visualize gene expression patterns within developing structures in a 3D framework has revolutionized developmental biology research. However, methods to precisely quantify these 3D expression distributions in a systematic manner are still lacking. We are developing a novel approach to combine OPT with Geometric Morphometrics (GM) methods to quantify the relationship between morphology and gene expression shape patterns. Here we propose a biologically-oriented extension to this project that involves embryonic phenotyping of the heart and limb of control and mutant littermates of an Apert syndrome mouse model. Apert syndrome is a rare congenital disease caused by one of two mutations in fibroblast growth factor (Fgf) receptor 2 that presents with severe craniofacial malformations, as well as other developmental defects, including heart and limb defects. The use of such mouse model will enable us to apply the OPT-GM approach to two different organs, by quantifying heart and limb shape in association with gene expression shape patterns of Fgf downstream genes at an early and a late stage of development. Comparison between control and mutant littermates will reveal differences in normal and disease-altered patterns of development, allowing us to describe exactly what has gone wrong during development, both at an anatomical and molecular level. These results will provide a better understanding of limb and cardiac morphogenesis, which can be further used in biomedical research of many congenital diseases, including congenital heart disease, which is the most common of human birth defects. Our goal is to demonstrate that the combined application of OPT-GM methods for fast and accurate phenoty
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Centre of excellence for space, planetary and astrophysics research Training and Networking'.

assistant: **Concept**

We propose to create a Centre of Excellence in the training of early stage researchers in the space, planetary (including Earth Observation) and astrophysical sciences in the Department of Physics and Astronomy at the University of Leicester.The principal aims of this centre will be to:- Provide a broad postgraduate training in space research that exposes students to different research disciplines and skills, leading to a recognized qualification (Masters degree or Doctorate).- Enable access to first class training in generic skills training to European students at a world-class centre for space research.-·Develop a collaborative training network, through the placement of students supported by the centre for periods in other European institutions, and by hosting nationally funded students from these places.- Provide a flexible training environment that early stage researchers can adapt to their cultural and gender needs and in respect of their national education systems.Key elements of the research programme will include space technology, earth observation and astrophysics, which are important foci in the Leicester centre. As a result we hope to produce...- A more adaptable nucleus of researchers, capable of fulfilling the needs of the European space, planetary and astrophysical science community, and able to become future leaders in these fields.- Researchers with better employability across a range of disciplines and outside academic research environments.- A European research capability that can meet the challenges laid out in the Green and White Papers on European Space Policy (both on europa.eu.int/comm./space/future/greenpaper_en.html, /space/whitepaper/index_en.html)).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Laboratori nazionali di frascati dell'infn' (LNF2000).

assistant: **Concept**

Description:The particle and nuclear physics research at the Laboratori Nazionali di Frascati of INFN is carried out at the Electron-Positron collider DAFNE.The collider is optimized to work at the phi mass with a high luminosity; as a consequence high precision experiments are carried out with 3 detectors: KLOE for the measurement of CP and CPT violation parameters in neutral kaon decays, FINUDA for the study of hypernuclei and DEAR for researching in the field of exotic atoms.The new collider, DAFNE, with its high circulating current represents also a powerful source of synchrotron radiation, from the infrared to the soft x-rays.The synchrotron light laboratory (DAFNE-Light) is in fact a new facility, almost unique in Europe, equipped to perform experiments in multidisciplinary areas such as biophysics, solid state physics and material science.The DAFNE beam test facility (BTF) is a beam line using the DAFNE Linac in a parasitic way. It can provide electrons (positrons) up to 800 (550) MeV with a 1% energy spread. This facility, very useful for detector calibration purposes, has been recently commissioned for single electron operation with excellent results, and will be soon available for users' access.Since 1995, the ultracryogenic detector for gravitational waves (NAUTILUS), is operating in Frascati. At present NAUTILUS is one of the two most sensitive gravitational wave detectors in the world with a sensitivity sufficient to detect sources located in our galaxy and in the local group.At the LNF a temperature variable cryostat with an 8T superconducting magnet is available for a.c. magnetic multiharmonic susceptibility and transport measurements as well as for critical current determination.A research group for the biodosimetric studies is also active at Frascati.Ap
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Deciphering the combinatorial signalling patterns in brain development by structural studies of axon guidance receptors and adhesive GPCRs' (ComplexSignal), addressing dissemination and exploitation.

assistant: **Impact**

Brain development relies on formation of functional neuronal circuits. This requires coordinated migration of embryonic neurons and their cellular processes such as axons to the target regions and their selective connections with synaptic partners. The migration of neurons and axons is mediated by guidance cues. Combined interactions of multiple guidance cues with their receptors direct neurons and axons to their final destinations. So far our understating is limited to the effect of individual cues, which result in attractive or repulsive responses. How multiple cues influence neuron and axon migration remains elusive. In addition, interactions of multiple cues and receptors are poorly understood. Our group recently elucidated the structure of an octameric super-complex fragment consisting of FLRT proteins, adhesion GPCRs Latrophilin and guidance receptors Unc5. In this project, we will aim at elucidating the full length (including the transmembrane domains) structure of the super-complex to reveal the molecular details of the interactions. Further analysis of structure-function relationship of the super-complex will, for the first time, address how modular architecture of these medically important receptors influence their signaling functions. Expertise of the host, capacity of the researcher, multidisciplinary approach of the proposal and well-planned implementation and risk mitigation strategies will ensure successful completion of the project. The results will enhance competence of the researcher; collaboration opportunities and competitiveness of the host and contribute to the excellence of European research.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Logic and Automata over Sequences with Data', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Formal language theory is indisputably one of the most successful theories  in theoretical computer science with many applications in such fields as formal verification, programming languages, and databases, to name a few. Despite this, the standard restriction to finite alphabets has been a limiting factor in the applicability of the theory in various important  application domains, wherein sequences with data (i.e. ranging over an infinite domain like the set of integers and the set of strings) naturally arise. This has motivated an extensive study of automata over infinite alphabets in the last three decades, which aims to develop algorithms for analyzing data languages. It was, however, quickly realized that permitting anything but the simplest data reasoning results in undecidability for the most fundamental models in the theory. Given the growing practical needs for tools for reasoning about sequences with data, it is crucial that we break through this undecidability barrier. The aim of the project is to overcome the current undecidability barrier in extending automata theory over infinite alphabets with complex data reasoning. The first concrete objective is, thus, to identify new decidable logic/automata models for data languages that permit complex data reasoning over various data domains (e.g. integer linear arithmetic, real-closed fields, string constraints, etc.), and to develop efficient algorithms for analyzing them. In addition to making fundamental theoretical contributions in automata theoryover infinite alphabets, I also aim to address the current practical needs for tools for reasoning about sequences.Thus, the second objective of the project is to transfer new algorithmic insights to the following important application domains:(1) querying graph data