RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Microglia phenotype in temporal lobe epilepsy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Microglia are the primary immune cells of the central nervous system (CNS) and are considered potential key players in the pathophysiology of temporal lobe epilepsy (TLE). Indeed, microglia activation is observed directly after status epilepticus and during epileptogenesis, both in TLE animal models as well as in human patients. Since microglia activation is correlated with the presence of pro-inflammatory factors, they are considered to be harmful. Recent findings, however, suggest that inflammation is a prerequisite to promote repair processes and that local microglia support cell survival and tissue repair. Moreover, TLE is also characterized by a massive infiltration of peripheral immune cells, including macrophages. Since it is impossible to differentiate microglia from invading macrophages in situ, the detrimental role attributed to microglia might be incorrect.We have recently developed a method to acutely isolate microglia/macrophages from mouse tissue and to subsequently discriminate microglia from macrophages using FACS sorting. In this research project, we propose to apply this method to further characterize the phenotype of microglia and compare it with that of infiltrating macrophages at various time points during the epileptogenesis phase of TLE. Using qPCR, flow cytometry and immunohistochemistry analysis, we will examine the expression of well-established phenotype markers for inflammation and supportive functions in a model of TLE and in human brain tissue. We hypothesise that a supportive role of microglia towards brain repair could pertain during epileptogenesis whereas infiltrating proinflammatory macrophages mediate devastating activity.The data that will be derived from this study will permit to better understand the role of microglia in TLE and ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'UV photochemical bleaching of phytoplankton and Coloured Dissolved Organic Matter and the interactive effects on the inhibition of photosynthesis and the production of phytoplankton sunscreeens.' to be submitted under Sixth Framework.

assistant: **Abstract**

Phytoplankton is the most important biomass producer in aquatic ecosystems. Recent research has shown a pronounced sensitivity of phytoplankton to ultra-violet (UV) radiation as a consequence of the substantial decrease in stratospheric ozone over high and mid latitude waters, which can result in a significant inhibition of photosynthesis. Solar UV radiation (in particular UV-B) affects the marine ecosystem through various processes, from photo-damage of phytoplankton cells and photo-inhibition of photosynt hesis, to photochemical bleaching of the colored fraction of dissolved organic matter (CDOM). Phytoplankton has developed various strategies to prevent from photo-damage and photo-inhibition under high irradiance i) in the visible through the production of photo-protective pigments (e.g., xanthophylls cycle), and ii) in the UV spectral range through the production of UV-absorbing compounds such as mycosporine-like amino acids (MAAs) which act as sunscreens. Colored dissolved organic matter is one of the mai n components controlling light penetration in the water column at shorter wavelengths. CDOM photochemical bleaching will thus result in a deeper penetration of light in the visible and UV range, and consequently can affect phytoplankton photosynthesis. The interactive effects of UV radiation on CDOM photochemical bleaching, and phytoplankton photosynthesis and photoprotective mechanisms requires further study. This proposal aims at examining these interactive effects using laboratory experiments on phytopla nkton cultures and field studies in open ocean and coastal waters in the English Channel over a seasonal cycle. State-of-the-art of optical techniques will be used to characterize the underwater optical properties and phytoplankton photosynthesis and natur al s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Unlocking the effect of residual elements via the NANOengineering of Sustainable MARTensitic steels'.

assistant: **Innovation**

The European steel industry is at a critical juncture, squeezed between brutal market conditions and the commitment to mitigate climate change. The iron and steel industry is responsible for high greenhouse gas emissions, particularly carbon dioxide (CO2), constituting 5.7% of the total emissions in the EU (2.2 tonnes CO2 per tonne of crude steel cast, refer to World Steel data). Several European steel producers (including ArcelorMittal) have committed to fulfilling the goals outlined in the Paris Agreement and aligning with the European Union's target of achieving zero emissions by 2050, as part of the Green Deal initiative. These engagements entail a shift from the predominant method of steel production, currently reliant on blast furnace/basic oxygen furnace (BF/BOF) technology, to cleaner production techniques characterized by significantly lower CO2 emissions. As the industry shifts toward cleaner production methods, particularly those utilizing electric-arc furnaces (EAF) and emphasizing the recycling of iron scrap, concerns arise about the potential contamination of steel with residual elements like Cu, Sn, As, Sb, and P.The NANO-S-MART project emerges as a response to this pressing need, focusing on the systematic and in-depth analysis of the impact of residual elements in martensitic steels. Martensitic steels, vital across key sectors such as construction, automotive, energy, and defense, play a pivotal role in the EU's efforts to achieve climate neutrality and increase renewable energy usage. The project addresses macro, micro, and nano-scale considerations, encompassing the entire steel production process. NANO-S-MART project aims to provide clear guidelines for redesigning grades and validating technologies in relevant environments. By bridging knowledge ga
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Space coding in hippocampo-entorhinal neuronal assemblies' (SPACEBRAIN).

assistant: **Concept**

Despite impressive advances in almost every field of neuroscience, our insights into brain function remain largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. Understanding how complex mental functions originate from electrical and chemical processes in brain cells requires a comprehensive and integrated multi-level analysis focused on neuronal assemblies and microcircuits, where myriads of intricately connected neurons with different properties act together. We shall use the coordinator’s recent discovery of entorhinal grid cells – a key cell type in the network for spatial representation and navigation – as a model for neuronal computation in non-sensory cortical microcircuits. The crystal-like structure of the firing fields of grid cells provides an entirely new route to access the neuronal interactions responsible for pattern formation in the brain. Using a forceful combination of computational modelling and novel electrophysiological, optical and molecular research tools never applied for circuit analyses in the brain before, we shall establish the mechanisms by which microcircuits in the hippocampus and entorhinal cortex encode, maintain and update representations of location as animals move from one place to another. Insights into the underlying computations have considerable translation potential. Understanding the algorithms for spatial navigation may change the way we manage a number of diseases, including Alzheimer’s disease, which commonly begins in the entorhinal cortex and has topographical disorientation as one of its most reliable symptoms, and it may provide European industry with radically innovative concepts for the design of artificial navigating agents.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Functional mechanism of heparin-binding hemagglutinin adhesin from Mycobacterium tuberculosis' (HADES), addressing dissemination and exploitation.

assistant: **Impact**

Tuberculosis (TB) is one of the most aberrant causes of global mortality and the molecular mechanisms of its pathogenesis are not well understood. The extrapulmonary dissemination of TB involves requires a crucial virulence factor designated as heparin-binding haemaglutinin adhesin (HBHA). HBHA is a 28 kDa dimeric protein localised at the surface of the Mycobacterium tuberculosis (MTB)  that binds dextran sulphate, dermatan sulphate, glycosaminoglycans and heparan-sulphate proteoglycans thus mediating the adhesion with epithelial cells and to extracellular matrix components. Despite a crucial role in the dissemination of TB, a key relevance as strong diagnostic antigen and as therapeutic target, there is currently limited understanding of the structure and mechanism of action of HBHA.The ambitious aim of this proposal is to characterise at high-resolution the mechanisms of function of HBHA in different phases of the life cycle of MTB. To achieve this ambitious target, we will carry out an integrated investigation of solution-state and solid-state NMR nuclear magnetic resonance (NMR) to acquire high-resolution data on the interaction of HBHA with membranes of MTB. The NMR experiments will be complemented with biophysical studies and mutagenesis to accurately define the relationship between structure, dynamics and function of HBHA.Our preliminary data suggest that this ambitious project comes at the most opportune time as we now have tools, materials and knowledge to resolve this important goal for biochemistry and reveal the propeties of a crucial molecule for the mechanism of extrapulmonary dissemination of TB.


**Keywords:** Nuclear Magnetic Resonance, Biochemistry, Protein Structure, Membrane Proteins
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Topological Quantum Gas Microsope' (TOQUAM) targeting Horizon 2020.

assistant: **Abstract**

In this project I will study the properties of interacting topological insulators using ultracold atoms in optical lattices.  To this aim, I will build the first bosonic quantum gas microscope that allows single site resolution in combination with excellent control of atomic interactions. This project will be able to detect and manipulate in-situ a wide number of topological Hamiltonians from the weakly to the strongly interacting regime. The first part of the project involves a construction stage. After characterization of the experimental setup, in a first series of experiments I will study the interacting 2D Su-Schrieffer-Heeger (SSH) model where higher-order symmetry-protected topological phases are expected. In this model, the control of interactions is crucial to observe interaction-induced topological phase transitions.In a second series of experiments, I will implement a new technique based on Raman-induced tunneling in state dependent potentials to create artificial gauge fields. This scheme will provide full control of the hopping matrix elements and will avoid the typical heating associated to driven-many-body systems in cold atoms experiments. The spatial resolution provided by the quantum gas microscope, the acquired knowledge provided by the interacting SSH model and the implementation of this new driving-scheme will open the possibility to study and prepare adiabatically for the first time a strongly-correlated topological phase.


**Keywords:** Artificial gauge fields, Optical Lattices, Quantum Gases, Topology, Topological insulators, Fractional Quantum Hall effect, Strongly interacting systems, Phase transitions, Chern insulators
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Shapes and Meaning. The matt-painted pottery of the North-Lucanian district: culture, identity, symbols and Gender. An interdisciplinary study of a local community in Southern Italy.'.

assistant: **Concept**

What were the communication systems of ancient societies without writing? Is it possible to use the decorations and symbols painted on the vases like a new Rosetta Stone? Is it possible to reconstruct the language of archaic communities that have disappeared? Objects convey ideas, memories and messages, and the ceramic decorations are certainly one of these vectors, of conservation but also dissemination of identity and cultural messages. Although it has all the potential to represent a privileged means of knowledge, most of its meanings still elude us. The objective of project SandMan (Shapes and Meaning) is to understand the ways of communication between the archaic communities of southern Italy, free of conventional forms of writing, between the end of Iron Age and the Archaic Period (mid-7th/mid-5th cent. BC). To achieve this goal, the project will use three different approaches: semiotic, archaeometric, and typological. The research aims to conduct a holistic, thus innovative, study of the symbols of ceramics in order to understand the meanings of this symbolic ""lexicon"", better understand how they were important for gender identification/distinction, how they were used as a way to communicate and how that knowledge was passed on to others. SandMan also proposes a systematic study of the matt-painted vases of southern Italy (to create a precise and reliable typology) and a chemical-physical analyzes, will investigate the fabric of vases with matt-painted decorations for to create a reference database of local workshops. In general, the studies have always focused on Greek (or Greek-colonial) objects present in the indigenous contexts, relegating the discovery of indigenous ceramics to a secondary position. This research, instead, using a post-colonial approach, w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development of metastable particle detectors and their applications to nuclear physics and astrophysics' in the context of a Fourth Framework call.

assistant: **Objectives**

Research objectives and content Metastable systems are presently being applied to particle detection, promising important improvements in special applications such as astroparticle or neutrino physics. We will study three such types of devices: collections of metastable microspheres, thin metastable strips, and dispersions of droplets of a superheated liquid. We plan to use superconducting Rhenium strips for searches of a non-zero neutrino mass signature in the spectrum of Rhenium's beta decay. In parallel to this, the microspheres will be used for a Dark Matter (DM) experiment to be installed in an European underground laboratory (Canfranc, Spanish Pyrenees). This detector's background rejection ability is expected to improve the present sensitivity to galactic particle DM. At the same time, a microsphere-based Transition Radiation detector (developed in collaboration with Taiwan) will be tested in an European high-energy electron beam. Finallyw last year we embarked in the development of Superheated Droplet Detectors (SDD) for panicle DM detection, an approach proposed by the applicant [ 11. These devices are expected to improve the present sensitivity to putative DM particles composing the galactic halo (WIMPS) by several orders of magnitude. During the length of this program a dedicated. large mass SDD will be built. tested and installed underground. [ll J.l. Collar, Phys. Rev. D 54 (1996) 1247. Training content (objective, benefit and expected impact) My experience in the fields of DM phenomenology, low background techniques, neutrino physics and radiation effects will be applied to these programs; in exchange I will receive a complementary education in superconductivity, cryogenic techniques, condensed matter and polymer science. In this sense the program offers a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transnational Cooperation among ICT NCPs', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The main objective of Idealist2018 is reinforcing the network of National Contact Points (NCP) for LEIT ICT under Horizon2020, by promoting further trans-national cooperation within this network. This cooperation will also include collaboration and networking with similar networks in parallel themes (Security, ENV, Transport, Energy, Health,…etc) especially in the context of joint/coordinated or PPP calls. Special focus is put on helping less experienced NCPs from Member States (MS) and Associated Countries (AC) to access the know-how accumulated in other countries and to apply it in a locally relevant and efficient manner.Furthermore Idealist2018 aims to address national and cross-border audiences, relying on the NCP network mainly established in the MS and AC at national and regional level, to stimulate, encourage and facilitate the participation of current and future ICT research stakeholders in ERA. Special focus is put on newcomers and SMEs, including organisations from MS, AC and third Countries.The activities of Idealist2014 are incremental to the formal NCP responsibilities as they address the international aspects not covered by the nationally funded NCP role. It is built upon:-Experience gained over more than 15 years from the 8 preceding projects covering FP4 to FP7 and now the transition to H2020-Strengthening NCP cooperation with support for MS, AC and third Countries-Provision of Training and Twinning for less experienced NCPs -Provision of partner search, pre- and full proposal quality support-Focused support for SMEs in the ICT sector and for organisations new to H2020-Provision of NCP support for countries with S&T international agreements -Promotion of opportunities and Idealist services ensuring a higher NCP visibility


**Keywords:** National Contact
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The impacts of global environmental change for marine biotic interactions and ecosystem functioning' (GLOBEF), addressing dissemination and exploitation.

assistant: **Impact**

Oceans cover 70% of our planet, provide 90% by volume of its biosphere, support 50% of global primary production and provide vital ecosystem services, including climate regulation, carbon sequestration and the provision of protein, on which large proportions of the global population rely. The Earth’s oceans are, however, increasingly subject to multiple interacting anthropogenic stressors. At the global scale, ocean acidification and global warming, considered two of the 21st century’s grand challenges, potentially pose the greatest threat to ecosystems and the goods and services they provide. However, regional scale stressors, such as eutrophication and over-fishing, are interacting with these global scale stressors, leading to non-linear ecosystem responses.   To date, there is little understanding of the combined impacts of these stressors on marine organisms or the processes that structure marine ecosystems. The proposed research seeks to directly address this knowledge gap by undertaking a series of novel, integrated, robust manipulative experiments, at a hierarchy of spatial (local to global) and temporal scales (short to medium term), to determine the combined impacts of multiple climate (global warming and ocean acidification) and non-climate (eutrophication) stressors on marine biodiversity, community interactions and ecosystem functioning. Outcomes from this research will provide the first quantitative evidence of how multiple, interacting global environmental change stressors will affect the strength and direction of biotic interactions, ecosystem functioning and through interdisciplinary collaborations, changes to food-web dynamics and the economic sustainability of our oceans. Without a multi-species, ecosystem-level understanding of marine biological respo