RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Participation of endomembranes and components of the cell wall on the maintenance of plant cell polarity' (MEPOLHAIR) under Sixth Framework.

assistant: **Objectives**

The mechanisms of tip-growth have been studied thoroughly for a long time, but the complex view is still far from complete. The main questions asked by scientists from different fields of cell biology are how tip growth is regulated, what is the principle of proper anchoring" of protein complexes required for root hair formation and what signalling background is involved in root hair tip growth. The aim of our project is the characterization of the integrity of growing tips by modern cell biological method s like live cell imaging, phenotyping of transgenic plants and mutant screening.This complex approach will be focused to determination of cell wall - plasma membrane interactions, sterol distribution in the plasma membrane, behaviour of structural components in the cell wall and the endocytosis in different developmental stages of root hair formation. Special attention will be paid to basic developmental checkpoints of root hairs under influence of changing environmental stress conditions. Experiments will be made in a multidisciplinary approach in collaboration with two other European Institutions by a combination of several cell biological and genetic techniques. Results will contribute to the understanding of regulated cooperation between cell wall, plasma membrane and intracellular signalling components determining root hair tip growth and plant cell polarity."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Algorithmic Containment of Threats in Graphs, Networks or Webs' (ACTING-NOW) under Horizon 2020.

assistant: **Objectives**

The project is about the security of networks, and how to select the best containing actions to perform when a network is threatened. Network security is a major concern for Europe in the guise of at least three threats: attacks on computer networks and related infrastructure; diseases spreading in networks consisting of people, livestock, crops or wildlife; and the spread of fires in forests or buildings. The project brings together an experienced researcher with a successful track record in “the firefighter problem” (which models the general network security problem), a supervisor with complementary expertise and world-leading research record in multi-objective optimization, a host organization with expertise and leading research groups in (i) Security, (ii) Randomized, heuristic optimization (from theory to industrial exploitation) and (iii) Human-Computer Interaction. Two non-academic secondment partners strengthen this team still further, bringing in industry-scale optimization experience (Noesis Solutions), and a long track record of advising for fire safety to major infrastructure projects including to the military (Lee Anderson). The experienced researcher will use the training and mobility afforded by this complementary partnership to further the impact of his research on European security, benefit from skills training in industrial exploitation and on offering policy advice, and learn a range of additional academic and non-academic skills from participating in the training of young researchers. Scientific results of the project include new, effective computational methods achieving better results in practical applications mentioned above. Theoretical understanding of spreading emergencies in graphs will be useful in fundamental research in other fields, for ex
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Galaxy evolution through Cosmic Time' (UNIMASS).

assistant: **Innovation**

Galaxies are the beacons that light up the distant regions of the Universe. Galaxies are also the building-blocks that chart the Universe. Understanding galaxies is essential for undertaking precision cosmology. Yet, their formation is still a mysterious process. Modern cosmological models are very successful at explaining the largest structures in the Universe. Yet, a coherent picture of how galaxies form their stars the way we see them and their evolution through cosmic time is still missing. This proposal seeks to significantly enhance our understanding of how galaxies form and evolve. This objective will be achieved by means of a synergetic study that brings together the most fundamental approaches to the problem. These are the development of galaxy evolution models as tools for interpreting galaxy data, the analysis of real galaxies, and simulations of galaxy formation in the framework of Cold Dark Matter cosmologies.  The novelty is to understand the properties of stars in real galaxies through cosmic epochs, and use them to construct galaxy formation theories. The properties of real galaxies will be inferred by applying new models for the light of stellar populations to modern observational data. We shall make use of data releases from observatories over the world. We shall then improve current simulations with the physics derived from observations and follow such simulations through cosmic time. This will enable us to check the match between theory and observations up to the very early universe. Through an iterative process of model-data comparison, we will include new physical mechanisms for regulating the formation of stars in galaxies including stellar and AGN feedback. By containing all the important ingredients, our comprehensive approach will bring theory
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Involvement of p27 in myc-regulated mammalian cell proliferation' (1994-1998) under Fourth Framework.

assistant: **Objectives**

The cell proliferation regulatory mechanism by Myc remains unclear. In a model of rat fibroblasts transfected by MycER conditional chimeras, activation of Myc induces the increase of cyclin E/cdk2 complexes-associated catalytic activity. Further data argued for an involvement of the cdk inhibitor p27 in this process since Myc activation of cyclin E-complexes correlated with the dissociation of p27 from these complexes and its loss from whole-cell lysates. The objectives of the present research proposal are 1) to provide some direct evidence that p27 is a relevant target for Myc and clarify its precise role in Myc biology. For this purpose, the effects of Myc activation on cyclin/cdk kinase activity will be analyzed by biochemical experiments in p27 knockout mice. 2) to identify the components induced by Myc, involved in degradation or in sequestration of p27. To address this issue, a genetic approach using the two hybrid system to screen in a rat fibroblast library the p27-interacting proteins complemented by a biochemical approach using gel exclusion or affinity chromatographies will be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pharmacological inhibition of macrophage activation' (FIREQUENCHER) under Horizon 2020.

assistant: **Objectives**

Macrophages are innate immune cells that specialise in sensing and responding to the presence of pathogens and they have been causally involved in the pathogenesis of both sepsis and rheumatoid arthritis (RA). Both diseases represent a high cost to the economy and society of European countries characterized by an aging population as well as developing countries. Sepsis is the first cause of death in hospitalized patient, with an estimate of 5 million deaths each year. Currently, there are no effective treatment protocols or strategies to deal with sepsis and several approaches targeting known cellularpathways have failed. RA is a chronic condition that affects 1% of the population worldwide. Despite the existence of established guidelines, 66% of patient inadequately respond to the therapy. Our group discovered that DNA damage is involved in the control of macrophages activation, unveiling a novel and untapped pathway potentially ripe for new approaches to modulate their activity. Thus, our proposed project is to test drugs targeting factors involved in DNA metabolism to treat inflammatory immune disease. Our plan involves a first part using an in vitro strategy to test the efficacy of the inhibitors on different macrophages cell lines and a second part involving the use of well-established animal disease models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fifth Framework proposal on 'Engineering a Co-operative Inter-Enterprise Management Framework - Supporting Dynamic Federated Organisations Management -'.

assistant: **Innovation**

The main objective of FORM is to engineer an open adaptable framework to support the management of trusted Co-operative Inter-Enterprise Environments encompassing telecommunication facilities and business automation systems - we call this an Interprise Environment.The operation and management of this environment is outsourced to an Interprise Provider which aims to provide the seamless co-operation of inter-organisational business processes. In a changing business environment, where co-operation between independent organisations to meet common business objectives is becoming the norm, this outsourcing enables the rapid integration of customer organisation systems with other customer or partner organisation systems.The project will develop and validate through trials, an Interprise Management Framework based on re-usable building blocks.Objectives:The objectives of FORM are to:* Develop an exploitable set of services, systems and components that aims to manage outsourced Co-operative, Inter-enterprises facilities, termed Interprise facilities* Develop an Interprise Management Framework that provides an environment for demonstrating and publicising the effectiveness of the service, systems and components to be exploited by individual partners. This Framework will align the technologies, models and techniques used for these individual products with each other and with relevant contemporary standards.* Publicise the Interprise Management Framework through technical dissemination, publication of guidelines and contributions to standards in order to support the marketability of the products conforming to the Interprise Management Framework.Work description:The major stages of work in FORM aim for the following:1. To provide an analysis of the Business Requirements for the man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'International dimension of environmental problems - an analysis from game models' (1994-1998) under Fourth Framework.

assistant: **Objectives**

Research objectives and content One of the most serious environmental problems in the next century will probably be the climate change caused by the increased concentration in the atmosphere of greenhouse gases. The aim of this project is to apply the new developments of the game theory (endogenous coalition formation and non co-operative models in the coalition formation) to the climate change negotiations. The current international negotiations having been studied, an appropriate game model will be chosen according to the relevant observed elements. Afterwards, a simulation will be carried through an iterative calculation. The objectives are: - to characterize the various existing coalitions and the stakes of their union, - to use different solution concepts, - to study the links between the intermediate coaltions and how transfers could be carried out, - to find the stability and the profitability of the agreement, that is of the Treaty on Climate Change which was signed at Rio in 1992. Training content (objective, benefit and expected impact) During the stay at the host institution, the modelling phase and the simulation will be led. The benefit will stem from elaborating the model and carrying out the simulation in collaboration with Prof. Tulkens, since his approach will be used. Indeed, this approach appears to square with what actually happens in the international negotiations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification of promoters and enhancers specific for inflammatory bowel disease and its subtypes' (IPEIBD).

assistant: **Concept**

Inflammatory bowel disease (IBD) comprises two main types of intestinal disorders: Crohn’s disease (CD) and ulcerative colitis (UC). The incidence and prevalence of IBD is highest in Europe and North America (incidence up to 24 per 100,000 person-years). IBD is not well-understood on a molecular level, and is challenging to diagnose correctly. As the disease is chronic, patients typically require life-long treatment, often with very expensive biological drugs, which are not always effective. Thus, there is a need to increase our understanding the disease, and develop better diagnostic methods so that the correct medication can be applied.   In this project we will analyze a unique emerging dataset of controlled gut biopsies taken from a large number of both UC, CD and healthy individuals (109 total) subjected to a unique RNA sequencing technology – CAGE – that can identify novel gene isoforms, transcribed enhancers and non-coding RNAs. As shown in our pilot study, such RNA has great potential as diagnostic biomarkers or even drug targets. The most significant RNA predictors for different IBD subgroups will be used as targets to develop diagnostic kits that will be validated, and ultimately applied, in a clinical setting. The host group of professor Sandelin has set up the CAGE technology that will be used for this analysis and the researcher, Dr Vitezic, did her PhD work on the analysis of data from this technology including human tissue samples while in Japan. The project is involving excellent academic and clinical environments and the applicant will spend time in both. This is a unique clinical genomics proposal focusing novel technology and European strengths, targeting a growing medical problem. Thus, it fits perfectly with the goals for the IF and Horizon 2020.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'In-K Strain System: Carbon Nanotube ink based realization of ultraflexible composite  strain sensors' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Since their discovery, carbon nanotubes are one of the most acclaimed materials in both science and industry. But despite all their useful electrical properties, as well as their flexibility and strength, carbon nanotubes have proven very difficult to manipulate and arrange into patterns and so to be used in industrial applications. Carbon nanotube ink was one of the great answers found by researchers: they dispersed multi-walled carbon nanotubes in water creating ink to be used through commercial desktop inkjet printers. The so created conductive inks have unique physical and electronic properties: In our In-K Strain System we make use of these exceptional properties for strain sensing. The In-K Strain Sensor is a next generation strain sensor, realized in carbon nanotubes and elastic composite material. It can be easily applied to almost any surface. The In-K Strain Sensor is the heart of the In-K Strain System, an innovative Sensor System able to reduce sensibly the cost of Structural Integrity Monitoring. The advantages of using printed carbon nanotube ink in the sensor realization are multiple: lower production and raw material cost, sensible shortening of sensor production time, perfect repeatability, extreme flexibility in sensor size, easy printing of bi- and tri-axial sensor elements. The results of our research and development were so promising to lead to a dedicated patent application, PCT extended. We expect an important competitive advantage for our Company to derive from the employment of carbon nanotube ink. Economic feasibility assessment and production upscaling are the main objectives of this study:- Deepening of production related aspects including cnt ink formulation- Development of an operational framework including development of further technologi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Network for Innovative Training on ROtorcraft Safety', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Helicopters and the other vertical flight vehicles, like tilt-rotors, compound helicopters, hybrids and rapidly expanding class of easy to fly vertical take-off personal vehicles, are expected to see widespread use in the future especially as means of transport, exploiting the formidable capability to provide point-to-point connections.However, if the expansion of the usage of rotorcraft vehicles were to follow the pace of grow followed by the fixed-wing public transport in the last years, there are several issues that need to be addressed urgently to increase the use and the public acceptance of rotorcraft. In particular, aspects related to complexity of the operations and safety are of primary importance, due to the fact that in the last 20 years helicopter accident rates, worldwide, remained unacceptably high, especially when compared with fixed-wing aircraft.The complexity of the phenomena that rule the functioning of rotorcraft calls for the development of engineers with a genuine multidisciplinary background. The key objectives of the NITROS training network are: to train the next generation of European aeronautical scientists and engineers on this type of flying machines developing the entrepreneurial attitude in them that is essential to introduce disruptive technological innovations; to train engineers to avoid overlooking the impact that their design choices may have on flight safety; to introduce innovations in rotorcraft design that will enhance the safety of helicopters, to obtain a significant reduction of the accident rate; to create a network of excellence of European institution dedicated to rotorcraft. All these goals can be reached by exposing the young researches to a dynamic network composed not only by some of the most renewed European engineering
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'SecQdevOps- Trustworthy Quantum DevOps for Secure Software and Hardware Quantum Engineering' (SecQdevOps).

assistant: **Innovation**

The emergence of quantum computing as a transformative technology has made secure hardware and software development an imperative. Quantum computing’s potential depends on robust, secure infrastructures that support quantum algorithms while addressing vulnerabilities. However, rapid development often prioritizes functionality and speed over security, creating gaps in comprehensive quantum-specific security practices, as highlighted by agencies like ENISA and NIST. Such gaps pose risks due to quantum algorithms' complex attack surfaces, which traditional security solutions cannot adequately address. This challenge is especially pertinent in the European Union (EU), where it is essential to integrate security engineering in both software and hardware development, ensuring compliance with EU standards and providing auditable quantum systems.The SecQdevOps project tackles these critical issues by creating a secure, continuous DevOps pipeline explicitly designed for quantum software and hardware development. Leveraging quantum high-level programming languages like Qiskit and Eclipse QRISP, alongside secure hardware-aware compilers, SecQdevOps provides automated security assessments and real-time vulnerability detection to build efficient, trustworthy quantum applications resilient to cyber threats. A unique aspect of SecQdevOps is the Internet of Quantum Things (IoQT), a distributed platform that connects emulated quantum devices across multiple secure nodes for collaborative testing and development, offering a secure “playground” for next-generation developers.