RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Next Steps in Securing the Sustainability of the European Social Survey, European Research Infrastructure Consortium (ESS-SUSTAIN-2)' (ESS-SUSTAIN-2), addressing dissemination and exploitation.

assistant: **Impact**

This proposal outlines a detailed plan for ensuring the sustainability of one of Europes leading social science research infrastructures - the European Social Survey, European Research Infrastructure Consortium (ESS ERIC). As a comparative general social survey the ESS needs to have generous national coverage to provide analytical power and ensure it keeps up with the changing scientific and research infrastructure landscape. Failure in one or more of these areas could damage or even destroy the infrastructure. This grant will substantially reduce the risk by securing the medium-term sustainability of the infrastructure and making it more resilient towards future challenges. The ESS has responded effectively to the ESFRI approach since it became an ERIC in 2013 and receives sizeable financial contributions from its members for core activities.ESS-SUSTAIN-2 aims to build on that support and creates sustainability through a structural strengthening of the ESS and by future proofing the infrastructure. ESS is not seeking another few years Commission funding to keep it afloat, an approach unlikely to yield long-term sustainability (and in any event these costs are now met by ERIC members). Rather it seeks a vital helping hand to help complete the transition of the ESS into a research infrastructure that is financially sound and scientifically equipped for the future.  By developing links with the European Values Survey, establishing global partners, engaging with policy makers, harnessing technology to improve efficiency and cost effectiveness and launching the worlds first probability-based online panel, this proposal aims to give the European Social Survey the strongest possible foundation to succeed in the years ahead.


**Keywords:** European Social Survey, Sustainabili
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Use of IgY to reduce methane emission from rumen archaea'.

assistant: **Objectives**

The IGYMERA proposal is aimed at exploring novel strategies to reduce methane production in ruminants. Our innovative proposal differs from other past strategies. Instead of using whole archaea for the development of antibodies, we will raise low-cost, specific and non-toxic IgY polyclonal antibodies against the key membrane targets responsible for methane production, or for their ability to produce a significant reduction in methanogenic microorganism populations in the rumen. To identify such targets, we plan to use state-of-the-art proteomic tools and molecular cloning techniques for the production of recombinant proteins to be used for hen immunization. We also plan to test an early intervention approach in the rumen of small ruminants (goats), to enhance the reduction in their microbial methanogen population during adult life.


**Keywords:** Archaea, IgY, Ruminant, Methane, Clime change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Gas Emission Measurements the Metal Quality Improvement Nas Complement to Contract No. G5Rd-Ct2000-00307.'.

assistant: **Concept**

To avoid the generation of solid by-products estimated around 50 millions tons per year in Europe, the design of an original on-line metallurgical treatment is proposed. A consortium involving the steel industry, the coal based power plants (Eastern Europe), the scrap industry (SME), the cement industry and a steel engineering company will develop a clean fusion-reduction technology for converting these adequately mixed by-products into valuable mineral and metallic materials. The metallic products will be used by the steel industry (carbon and alloyed steel grades) while the mineral components will benefit to the cement industry as substitutes of the Portland clinker allowing to reduce by 25% the CO2 emissions from that sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Functional genomics of innate immune pathways in mammalian cells'.

assistant: **Innovation**

The innate immune system provides the first line of immune defence against infectious diseases and in the fight against cancer. The direct recognition of bacteria, viruses and cancer cells by innate immune cells is crucial for priming of the adaptive immune response and the establishment of immunological memory.Innate immune signalling pathways mediated by Toll-like receptors are quite well studied. Little is known about the activation of additional signalling pathways in innate immunity. This project aims at the identification of novel molecules in innate immune pathways in mammalian cells by functional genomics. The focus will be on signalling pathways in myeloid cells involving the Immunoreceptor Tyrosine-based Activation Motif (ITAM) containing adaptor DAP12 and additional innate immune signalling pathways.These studies will include the identification and investigation of innate immune pathways in response to their natural ligands, bacteria and viruses. Powerful technologies of refined retroviral expression cloning combined with advanced proteomics will be applied to identify novel molecular targets by functional read-outs.The molecules originating from the screens will be validated by gene over-expression and gene knock-down in primary immune cells and in in-vivo mouse models. These studies have the potential to increase the basic knowledge in innate immunity and to identify novel drug targets. Molecular targets for agonistic compounds might be identified to provide new anti-viral and anti-bacterial drugs to fight against emerging infectious diseases.The screens might also discover molecular targets for antagonistic compounds for indications of inflammatory diseases and septic shock syndrome. The scientific expertise of the team leader and excellent facilities at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The role of epigenetic factors in the aetiology of common complex diseases using twins' (EPITWIN).

assistant: **Innovation**

Twin studies traditionally have been used to assess the relative contributions of genetic and environmental factors. Nearly all common diseases and traits have now been found to be heritable and GWA studies are discovering many novel genes. However 95% of the heritability is not yet identified and discordances within identical (MZ) twin pairs cannot be explained by known environmental factors. The missing heritability could be due to epigenetic factors- which are ideally studied with twins. The proposed study uses MZ twins discordant for 10 important age-related complex disease traits to uncover epigenetic signals that are associated with disease. We will study in detail epigenetic differences using a high throughput Illumina methylation array in the 5% most discordant pairs for the following disease susceptibility traits : obesity (BMI), type II diabetes (insulin resistance) , hypertension (BP), hyperlipidemia (lipid levels), Osteoporosis (BMD), biological aging (white cell telomere levels), Allergy (IgE) , asthma (FEV1), platelet volume (MPV) and smoking. We will use the TwinsUK cohort of 3000 phenotyped MZ twins for a discovery group. For replication of the most significant associations we will use singletons from the 200 extreme highs and lows of the remaining 4000 phenotyped twins as a ‘case’-‘control ‘association study genotyped by the same array. A sub-sample will be genotyped by sequencing. To assess tissue specificity, additional tissues for methylation analysis will be sampled (buccal, fat and skin DNA). Causality will be explored using bioinformatics, cell specificity experiments and longitudinal studies using DNA stored for up to 15 years- as well as parental and offspring DNA. Epigenomics is a major future growth area. This large scale study would enable us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Reconsidering Constitutional Formation.Constitutional Communication by Drafting, Practice and Interpretation in 18th and 19th century Europe' in the context of a Seventh Framework call.

assistant: **Objectives**

The genesis of the modern constitutional state in late 18th and 19th century Europe has met im-mense public awareness and cross-border participation. Though this phenomenon is well known, basic patterns of constitutional communication (i.e. socio-cultural and cross-border contexts, ‘Zeitgeist’) have never been addressed before. In this concern ReConFort applies an evolutionary, dynamic and interactive concept of forming constitutions by text, societal context, political practice, constitutional interpretation and communication.The transdisciplinary project focuses on the constitutional “discourse” around selected constituent assemblies: the Polish Sejm (1788-1792), the Spanish Cortes (1810-1812), the Belgian National Congress (1830-1831), the Frankfurt Parliament (1848-1849) and the Italian Parlamento Subalpino (1861). Albeit all these historical paradigms are particular and different, they all shared a Europe-wide public interest. The research approach draws upon mainly inedited and still unknown archival sources: cross-border correspondences, publicistic activities of protagonists, exile literature, and regional to cross-border constitutional journalism in leading public media. The synchronic comparative analysis is complemented by systematic diachronic studies. Thereby ReConFort identifies common structural criteria, features and principles in constitution forming processes.ReConFort finally aims at assessing basic determinants and mutual interdependencies of constitutional formation and communication in Europe. This research focus will estalish a deeper understanding of mutual influences of constitutional developments in Europe by pointing out the transnational dynamics of constitutional forming, practice and interpretation. Thus, ReConFort crosses the frontiers of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Latin American Testimonies in Italy: a Living Library Between the Mediterranean and the Andes' (LATILMA).

assistant: **Concept**

The aim of the project ""Latin American Testimonies in Italy: a Living Library Between the Mediterranean and the Andes"" is the collection, analysis, and dissemination of testimonies of Latin American migration to Italy during the last thirty years. The study will be carried out from a gender perspective, focusing on the migration of women and LGBTQ people, to underline cultural and literary aspects related to migration and determined by migrants' intersectional conditions.In addition, particular attention will be paid to testimonies by people from the Andean area, given their importance in Italy. The collection of ""migrant memories"" from a gender perspective will take place both in Italy and in the area of ​​origin of the Andean migrant communities, thus wanting to reconstruct the narrative of a to-and-fro migration. The project wishes to underline the creation of an image of the migratory experience that also involves places of departure, families and that, in this way, tells the cultural impact of migration both on the places of origin and on those of arrival, overcoming a vision of migration as a linear and one-way process, on the one hand, and also overcoming old concepts such as those of “center” and “periphery” at a cultural level. In the second part of the project, the collected testimonies will be published as an online, multimedia, and open access anthology. It will include an introduction written by the Researcher and by two authors selected from among those who created the included works, to recognize the subjectivity and authorship of the protagonists of the testimonies. The multimedia anthology will be made available, among others, to Language and Translation students of the European, American, and Intercultural Studies of the Sapienza University of Rome
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Opening the black box of nature valuation: the case of UNESCO nature parks in Europe' (NatUval) under Horizon 2020.

assistant: **Objectives**

This project will shed a new light on the valuation of nature and will thereby contribute to preparing European society for what has been called the Anthropocene. NatUval will develop empirically grounded knowledge on how environmental valuation shapes the roles of, and relations between, people, objects, concepts and methods associated with the management and justification of nature parks. Different valuation practices currently coexist in international institutes for environmental conservation. The objective is to (1) conceptualize how values are attached to ecosystems and landscapes in those institutes and to (2) develop a first typology of environmental valuation practices in order to (3) set the outlines for a systematic and long-term empirical research on the performativity of environmental valuation and its consequences for environmental management.Building on my previous experience and research principles of grounded theory and Actor-Network Theory, my systematic approach will develop and apply an analytical toolbox on two contrasting case studies in order to (1) assess similarities and differences as well as complementarities and frictions between different valuation practices and (2) evaluate the performative work of a selected sample of valuation tools. NatUval combines document analyses with participatory observation of meetings and in-depth interviews of staff and volunteers around two nature parks in Europe and at UNESCO and the IUCN. Insights from these case studies will be used to update the analytical toolbox and develop a typology of valuation tools.Since environmental valuation is core to environmental management, I am highly convinced of NatUval’s societal importance. Different dissemination and communication strategies will be used to maximize impac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The Time of Early Metalwork in Prehistoric Italy' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The researcher is moving from Italy to the UK in order to build a new chronology and classification method for early metal artefacts (i.e. axes, daggers and halberds) from Italy, c.4500-2000 BC. The project aims will be achieved through a combination of radiocarbon dating and scientifically informed work on artefact classification criteria, which takes into account the technological transformation undergone by the objects during their life-cycles. The importance of the project is twofold: (a) this is the first time that a researcher develops a reflexive approach to metalwork classification, which explicitly takes into consideration forging, use and other post-casting alterations to the shape and features of objects; (b) it is also the first attempt ever made to ground the chronology of early Italian metalwork in a comprehensive set of radiocarbon dates. The significance of the project goes beyond Italian archaeology insofar as early Italian metals are typologically cross-linked to similar objects in Europe and the Mediterranean. It is thus anticipated that the project will bring about dramatic changes in our understanding of the chronology and developmental sequence of prehistoric metal technology across large swathes of Europe, with particular reference to central Europe, the western Balkans, Sardinia and Crete. Whilst working on the project, the researcher will acquire new expertise in metalwork use-wear analysis and Neutron Diffraction (ND) analysis, two cutting-edge techniques of artefact characterization. ND analysis will be deployed during a secondment at the ISIS Facility, Rutherford Appleton Laboratory (Didcot, UK). The researcher will also develop new skills in radiocarbon dating, artefact classification and statistical analysis. Newcastle University, the host
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Cluster for Electronic Trading Systems, Transaction Management, Brokerage and Negotiation' (TRANSACT).

assistant: **Innovation**

The TRANSACT project has the following objectives: 1.Survey and structure activities and results from IST R&D projects in the area of Electronic Transactions. 2. Support collaboration both across the Net and through workshops. 3. Disseminate results and publication of the cluster and individual projects. 4. Support the Commission by providing a survey on trends and developments in the R&D area. 5.Utilise a virtual collaboration tool that support knowledge and content creation and management. It is the overall objective of TRANSACT to accelerate the speed of collaboration and dissemination of IST results.The content-oriented WPs can be chronologically ordered according to the three main tasks of the project and to the information flow between them: 1. Survey & Synergy: the structuring of the cluster's projects and domains is the subject of the task. 2.Collaboration: lessons learned and results will be a feedback to the clustered projects. 3.Commission Support. This is an external feedback action that provides the Commission with results and proposals that come up under the clustering activities. 4. Dissemination and publications: in this case, the public is the receiver of cluster results. A Project Documentation Repository will be developed that serves as as basis for open discussion and critical feedback mechanism on all relevant projects contributions. TRANSACT will invite members from different domains such as former active participants in the 4th Framework transaction cluster (30 projects), new projects that fall under the domain of TRANSACT, representatives from other clusters accompanying research institutes such as JRCs, and other companies or individuals that prove to support the clustering goals and activities.OBJECTIVESThe TRANSACT project has the following ob
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Transcriptional regulation in synaptic plasticity, learning and memory under normal and pathological situations'.

assistant: **Objectives**

What changes occur in the brain when we learn and how is the new information stored? Memories appear to be encoded as changes in the strength of specific synaptic connections while their stabilization is achieved by changes in gene expression.Specifically, the CREB family of transcription factors is one of the core components in the molecular switch that converts short- to long-term memory. Angel Barco, the proposed Team leader, joined the group of Dr. Kandel at Columbia Univ. and generated a number of lines of mutant mice in the CREB activation pathway to gain new insights into its function.He used recent technical advances in mouse genetics that allow restricting, both anatomically and temporally, the expression of a genetic alteration. This allowed a precise examination of the role of CREB in hippocampal synaptic plasticity and spatial memory.A first study describing one of these lines of genetically modified mice, published in Cell, provided important insights into the molecular mechanisms of synaptic-specific potentiation and the role of transcription in this process; several manuscripts describing other aspects of these mice phenotype are in preparation.Now, together with the Instituto de Neurociencias (Spain), he proposes to continue and extent these studies with the analysis of other mutant mice in this pathway, applying a multidisciplinary approach that combines molecular biology, mouse genetics and behaviour with electrophysiology.The goal of this proposal is deciphering the genetic programs required for long-lasting synaptic plasticity, learning and memory. This knowledge may reveal how dysfunction of these molecular processes leads to neurological disorders and open new therapeutics avenues for restoring normal brain function, indeed this may be the case for