RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'High-valent protein-coordinated catalytic metal sites: Geometric and Electronic ARchitecture' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

It is estimated that almost half of all enzymes utilize metal cofactors for their function, for example the respiratory complexes and the oxygen-evolving photosystem II, the most fundamental requirements for aerobic life as we know it. If we could mimic nature’s use of metals for harvesting sunlight, energy conversion and chemical synthesis it would eliminate the need for fossil fuels and greatly increase the possibilities of chemical industry while reducing the environmental impact. Achieving this type of chemistry is an outstanding testament to evolution and understanding it is a glaring challenge to mankind.These types of reactions are based on very challenging redox chemistry (involving one or several electrons). The key catalytic species are generally high-valent metal clusters with a varying ligand environment, provided by the protein and other bound molecules, that directly controls the reactivity of the inorganic core. To be able to understand and mimic this chemistry it is of central importance to know the geometric and electronic structures of the metal core as well as the entire ligand environment for these usually short-lived and very reactive intermediates. It has, for a number of reasons, proven extremely challenging to obtain these for protein-coordinated catalysts.The central goal of this project is to determine true and accurate geometric and electronic structures of high-valent di-nuclear Fe/Fe and Mn/Fe metal sites coordinated in protein matrices known to direct these for varied and important chemistry. By combining new X-ray diffraction based techniques with advanced spectroscopy we aim to define how the protein controls the entatic state as well as reactivity and mechanism for some of the most potent catalysts in nature. The results will serve as a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Searoutes - advanced decision support for shiprouting based on full-scale ship-specific responses as well as improved sea and weather forecasts including synoptic, high precision and realtime satellite data'.

assistant: **Concept**

Constantly improving forecasts of sea state and sea weather, including near real-time data from high resolution and high precision altimeter satellites, shall be integrated into advanced decision support systems for captains and ship management concerned with routing performance of specific ships. Fast container and ferry vessels and super fast monohulls and catamarans will be dealt with in particular. Routing performance should be optimised in order to increase safety, economics, reliability and environmental friendliness of sea transport. Transport links to be investigated are intercontinental (North Atlantic) and European short sea shipping routes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Large Passenger Aircraft Innovative Aircraft Demonstrator Platform' (GAM-2020-LPA), addressing dissemination and exploitation.

assistant: **Impact**

Main objective for the Clean Sky 2 Large Passenger Aircraft Programme (LPA) is to further mature and validate key technologiessuch as advanced wings and empennages design, making use of hybrid laminar airflow wing developments, the integration of most advanced engines into the large passenger aicraft aircraft design as well as an all-new next generation fuselage cabin and cockpit-navigation. Dedicated demonstrators are  dealing with Research on best opportunities to combine radical propulsion concepts, and the opportunities to use scalled flight testing for the maturation and validation of these concepts via scaled flight testing. Components of Hybrid electric propulsion concepts are developed and tested in a major ground based test rig. The LPA program is also contributing with a major workpackage to the E-Fan X program. The R&T activities in the LPA program is split in 21 so-called demonstrators. In the project period 2020 and 2021 a substantial number of hardware items ground and flight test items will be manufactured, assembled tested. For some large items like the Multifunctional Fuselage demonstrators or the HLFC wing ground demonstrator the detailed design and manufacturing of test items will be commenced.For the great majority of contributing technologies a Technology Readyness level (TRL) 3 or 4 will be accomplished or even exceeded.Based on data generated for each key technology contributing to the LPA program inputs will be provided to the CleanSky Technology Evaluator via the integration in agreed concept aircraft models in order to conduct the overall CS2 assessement. LPA is also contributing to conduct Eco Design Life Cycle assessements for selected LPA technologies.


**Keywords:** Large aircraft, large scale demonstration, integration of innovative propu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of the cyclin dependent kinase inhibitors p15 and p16 in multistage skin carcinogenesis in the mouse' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

CANCER IS A DISEASE CHARACTERIZED BY LOSS OF CELLULAR GROWTH CONTROL. AS SUCH, IT IS NOT SURPRISING THAT THE MOLECULAR MACHINERY OF THE CELL CYCLE IS INVOLVED IN TUMORIGENESIS. RECENT DISCOVERIES HAVE BROUGHT SEVERAL CELL-CYCLE REGULATORS INTO SHARP FOCUS AS FACTORS IN HUMAN CANCER. AMONG THE MOST CONSPICUOUS TYPES OF MOLECULE TO EMERGE FROM ONGOING STUDIES IN THIS FIELD ARE THE CYCLIN-DEPENDENT KINASE INHIBITORS SUCH AS p15 AND p16. THE EMPLOYMENT OF SUITABLE ANIMAL MODEL SYSTEMS WOULD GREATLY FACILITATE THE INVESTIGATION OF THESE GENES IN THE PRESENT PROJECT IT IS INTENDED TO USE THE MULTISTAGE SKIN CARCINOGENESIS MODEL BECAUSE THE STAGES OF INITIATION, PROMOTION AND PROGRESSION ARE WELL CHARACTERIZED. THE AIM IS TO ADOPT TWO COMPLEMENTARY APPROACHES. THE FIRST IS DESIGNED TO ANALYSE IN DETAIL THE GENETIC ALTERATIONS OF p15 AND p16 GENES. THIS ANALYSIS GIVES US THE OPPORTUNITY TO IDENTIFY THESE GENES AS TARGETS FOR THE ACTION OF CARCINOGENS. THE SECOND IS BASED ON THE IDENTIFICATION OF FUNCTIONAL ALTERATIONS OF THESE GENES ASSOCIATED WITH SPECIFIC STAGES OF CARCINOGENESIS.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Deciphering and predicting the evolution of cancer cell populations'.

assistant: **Innovation**

The fundamental evolutionary nature of cancer is well recognized but an understanding of the dynamic evolutionary changes occurring throughout a tumour’s lifetime and their clinical implications is in its infancy. Current approaches to reveal cancer evolution by sequencing of multiple biopsies remain of limited use in the clinic due to sample access problems in multi-metastatic disease. Circulating tumour DNA (ctDNA) is thought to comprehensively sample subclones across metastatic sites. However, available technologies either have high sensitivity but are restricted to the analysis of small gene panels or they allow sequencing of large target regions such as exomes but with too limited sensitivity to detect rare subclones. We developed a novel error corrected sequencing technology that will be applied to perform deep exome sequencing on longitudinal ctDNA samples from highly heterogeneous metastatic gastro-oesophageal carcinomas. This will track the evolution of the entire cancer population over the lifetime of these tumours, from metastatic disease over drug therapy to end-stage disease and enable ground breaking insights into cancer population evolution rules and mechanisms. Specifically, we will: 1. Define the genomic landscape and drivers of metastatic and end stage disease. 2. Understand the rules of cancer evolutionary dynamics of entire cancer cell populations. 3. Predict cancer evolution and define the limits of predictability. 4. Rapidly identify drug resistance mechanisms to chemo- and immunotherapy based on signals of Darwinian selection such as parallel and convergent evolution. Our sequencing technology and analysis framework will also transform the way cancer evolution metrics can be accessed and interpreted in the clinic which will have major impacts, ran
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Comparative analysis of institutional arrangement experiences and integrated coastal zone management in three European countries, France, Norway and Greece' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

This programme acknowledges the rise of claims other coastal resources that have been or might become the source of conflicts. Beyond sectorial policy needs, it also supports the idea that potentially contradicting socio-economic and environmental objectives are of equal importance and that ways of integration should be further developed through Integrated Coastal Zone Management planning The purpose of the programme is to investigate the institutional needs to improve this integration of coastal zone management policies. The research is based on in-depth and comparative multi-disciplinary analysis of three national situation: France, Norway and Greece. In each country, one study-area has been selected to illustrate this comparison. All study-areas are very representative of the present state of ICZM initiatives in their country and they well represent the diversity of coastal zone occupation in Europe. The general objective is to propose a multi-disciplinary assessment of institutional arrangements experienced or needed to improve the co-ordination of socio-economic development policy and environment or resource sectorial policies. The disciplines involved in the programme are in the area of social sciences. They are political sciences, law, sociology and economy. All participants to COASTMAN are involved in research programmes in the study-areas associating social and natural sciences. The programme will benefit from these links but intends to remain a social science research as it focuses at institutional analysis, an area where analytical and methodological frameworks exist but have yet been very little applied to ICZM. This general objective of the research is divided in the following three objectives: 1 - to describe and evaluate the terms of emergence of ICZM ini
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Generation of mouse models for the study of cellular senescence in aging and cancer', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Cellular senescence is a central biological mechanism for cancer prevention in mammals. Cells enter senescence when tumor-inducing genes are aberrantly activated, and in response undergo an arrest in proliferation accompanied by dramatic changes in metabolism and morphology, thus preventing their further development into tumors. Various types of physiologic stresses can also induce senescence, and this process is thought to play a central role in promoting aging, possibly by limiting the proliferative potential of stem-cell pools. While much is known about senescence in cultured cells, basic questions regarding the roles of this process in the living organism are still unanswered. In this proposal we describe the development of systems for the study of senescence in the living organism. We utilize the two central molecular activators of senescence: the p16INK4a and p19ARF genes. These genes are specifically induced during cellular senescence, and their expression is sufficient to induce this state. We will develop and characterize mice in which the expression of p16INK4a or p19ARF can be induced in multiple tissues through tetracycline administration, in order to induce cellular senescence in these tissues. This will allow us to experimentally generate senescent cells in the adult mouse and characterize their molecular and functional traits. We will study the effects of cellular senescence on tissue and organism physiology, and assess whether induction of senescence induces aging-like phenotypes. This system will provide the first genetic system to study this central biological program in its proper physiologic context, shedding light on aging processes and cancer prevention mechanisms.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Multiferroic Oxide 2DEgs for Reconfigurable nonvolatile memory Nanodevices (MODERN)' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The main idea of MODERN project is the realization of novel Ferroelectric (FE) and multiferroic oxide two-dimensional electron gases (2DEGs) characterized by a metal-insulating transition as function of the FE-polarization direction. By locally switching-on and off the 2DEG using a scanning probe, devices with arbitrary nanoscale geometry will be demonstrated and sketched in a non-volatile manner, to realize prototype FE field effect transistors (FET), spin-FET and spin-charge conversion circuits for the generation and detection of spin-currents, all operating at ultra-low power energy density. To achieve the objective, two heterostructures platforms will be studied and realized: 1. K0.5Na0.5NbO3 (KNN)/KTaO3 2DEG, where KNN is a well-known lead-free FE layer and KTaO3 is an oxide characterized by a large SOC (up to 0.4 eV), that develops an interfacial 2DEG. Here KNN can both act as FE-layer with large polarization (up to 30 µC/cm2) and as interfacial donor of carriers by Nb-doping of the interface.2. Delta-doped LAO/SrVO3 (down to 2 unit cells (UCs))/SrTiO3. Here, two UCs of VO2-terminated SrVO3 have been theoretically predicted to become a 2D multiferroic, with in plane FE order and an antiferromagnetic magnetic order


**Keywords:** MULTIFERROIC, 2 DIMENSIONAL ELECTRON GASES (2DEGs), SCANNING PROBE MICROSCOPY,  SPIN-ORBIT INTERACTION, FERROELECTRICS, MAGNETISM, MAGNETOTRANSPORT, PLUSED LASER DEPOSITION (PLD)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Cycloidal Rotor Optimized for Propulsion'.

assistant: **Concept**

The CROP project introduces an innovative propulsion system for aircrafts based on the cycloidal rotor concept, using an integrated approach that includes the electric drive train, airframe integration and an environmental friendly energy source.The CROP system is supported on a multiphysics approach:1. The high thrust is obtained by unsteady-based cycloidal rotor operation;2. The development of low-weight electric power drives for the system;3. Airframe re-design to accomplish optimum integration of the cycloidal propulsor;4. Environmental friendly energy source based on hydrogen and photovoltaic cells.The strengths of the CROP concept are:- High thrust levels: by using unsteady airflows- Low weight: using an integrated design approach between airframe and cycloidal propulsor- Environmental friendly: because it is based on green energy power sources.The revolutionary CROP propulsion concept will introduce new air-vehicle concepts, overcoming traditional limitation on short take-off and landing, including hovering capability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Optical frequency conversion in semiconductor heterostructures', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Despite their crucial importance for applications in information technology, cheap and manageable solid state sources are not available in wavelength ranges of interest. These include blue and near-UV lasers (for high density optical storage) and room-temperature tunable mid-infrared lasers (8 - 12 fm, for spectroscopic monitoring of pollution). The purpose of this project is to demonstrate the feasibility of coherent sources at these wavelengths by optical frequency conversion in semiconductor heterostructure waveguides. To obtain blue radiation, commercial GaAs-based near infrared lasers can be doubled in ZnSe/ZnMgSSe nonlinear waveguides grown on GaAs substrates. On the other hand, 8-12 fm radiation can be generated as the difference between two near infrared sources in GaAs/AlGaAs waveguides. These two devices should benefit from high nonlinear coefficients of GaAs and ZnSe, possibility of monolithic integration with GaAs-based sources and precise control of geometrical parameters in guide structures grown by molecular beam epitaxy. We propose to realize demonstrators of these two devices, to compare their performance to that of conventional nonlinear devices and to investigate new possibilities inherent to semiconductor-based second order nonlinear optics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Wind energy for the built environment'.

assistant: **Innovation**

In the opinion of the partners, the outcome of the project has more than exceeded our expectations. The focus of the current project has been on the development of wind enhancement and integration techniques which improve the annual energy yield per installation by concentrating the low to moderate wind speeds typical of most urban areas in Europe.This involved balancing and reconciling aesthetic, aerodynamic, architectural, structural and environmental concerns. Specific achievements include:- identifying and assessing types of urban locations where wind turbines could be placed (either as stand-alone machines or integrated into buildings);- assessing the relative performances of a whole range of conventional and aerodynamic building shapes;- assessment of energy potential by use of wind-tunnel testing on small-scale models and computational fluid dynamics simulations;- development of methods for analysing the wind regimes in specific urban locations using statistical wind data, and, for assessing the potential annual energy contribution of one or more turbines integrated into a building;- exploration of building aesthetics with reference to visual impacts of such schemes;- optimisation of architectural space and building services;- development of prototype structural systems for supporting turbines and isolating vibrations from buildings;- development of prototype safety devices to address public safety concerns;- study of impact of noise emissions from integrated turbines on building and immediate surroundings.Field-testing of small wind turbines (both VAWT and HAWT) integrated into a prototype aerodynamic building (approximately 1/20th scale) employing these principles was successfully completed.In comparison to an equivalent stand-alone machine, the turbines integr