RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Embryogenesis is achieved by the close interplay between the gene regulatory networks that control cell fate specification and the physical processes by which the embryo takes shape. While each of these systems has been extensively investigated over the past decades, comparably little is yet known about how they functionally interact across different scales of organization within the physiological context of the developing embryo. The central aim of this proposal is to elucidate the fundamental principles underlying the interaction and feedback between cell mechanics and fate specification during vertebrate gastrulation. Using zebrafish as a vertebrate model organism, we will explore how germ layer progenitor cell fate specification affects the physical processes by which the gastrula takes shape, and, vice versa, how alterations in cell/tissue mechanics feed back onto the gene regulatory networks and signals controlling progenitor cell fate specification during gastrulation. To dissect the fundamental mechanisms underlying this crosstalk, we will combine genetic, cell biological and biophysical experimentation with mathematical modeling. We expect that this transdisciplinary approach will provide answers to a central yet unresolved question in developmental biology: how the interplay between cell mechanics, dynamics and fate specification drives embryo morphogenesis and patterning.


**Keywords:** Cell biology, signal transduction, organogenesis, developmental genetics, pattern formation in plants and animals, stem cell biology
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DRAGON in support of harmonizing European and Chinese marine monitoring for environment and security system' (DRAGONESS).

assistant: **Innovation**

Capitalizing on the ongoing DRAGON project and the outcome of the EU FP6 MERSEA Strand-1 project the DRAGONESS SSA proposal aims to assess, advance and harmonize European and Chinese capacities in marine monitoring for environment and security.The primary objective of the DRAGONESS SSA proposal is to make an inventory of Chinese and European capacities of marine monitoring for environment and security including Earth observation data, in order to harmonize methods in the frame of international programs such as GOOS and GMES and investigate the potential for establishing and harmonizing operational services contribution to GEOSS. In so doing DRAGONESS will take stock of existing information production and service deliveries in order to: identify service/data gaps and barriers; develop activities to disseminate and implement products and services derived or customized from current GMES development activities;
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Trusted, traceable and transparent ontological knowledge on blockchain' (OntoChain) under Horizon 2020.

assistant: **Objectives**

During the last years we are witnessing an ever increasing number of Internet-based marketplaces that capitalize on the unused capacity of assets they already possess, while consumers can receive services from their peers owning assets either for free or at a lower cost. At the same time, the emergence of cryptocurrencies and smart contracts have enabled new distributed application ecosystems, e.g., Ethereum, Hyperledger Fabric, Stellar, Waves, etc., where new services can be deployed with low-entry market barriers, due to minimal infrastructure costs and decentralized and secure transaction management. Innovative business models arise where part of the value generated by these distributed apps is fed back to the distributed blockchain community, as remuneration for their contribution of computational resources. Companies and organizations still require trust: they need to understand their user base, verify identity, manage digital assets, and control trust issuance within their ecosystem. To maximize the market impact of this new economic environment, OntoChain aims to enable trustworthy transactions of services and content. OntoChain will define innovative decentralized reputation models that reveal hidden quality and/or type of providers/services, or credibility of data sources, while adequately balancing the trade-off between privacy and trust. OntoChain will enable trustworthy and traceable content handling where authorized parties can process data according to the privacy policies of the data owners. At the same time, it will build an economically sustainable ecosystem, where the total value generated in the system, in terms of profit or well-being, surpasses the total operational costs in terms of electricity consumption. In order to sustain the user community, O
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Bimetallic Complexes for the Activation and Catalytic Functionalisation of Vinylic C-H Bonds' (Bim-CH-Act).

assistant: **Innovation**

The catalytic and selective functionalisation of C–H bonds of organic molecules is a key enabling technology that has the potential to contribute to the sustainable production of commodity chemicals. This proposal targets the selective catalytic functionalisation of vinylic C–H bonds of unactivated olefins (e.g. ethylene, propylene) with novel heterometallic complexes based on abundant and inexpensive elements (e.g. Fe, Al or Ga). Despite appearing simple, this transformation is unprecedented. With nearly all systems studied to date, competitive π-coordination of the olefin to the metal site inhibits catalytic C–H functionalisation. In this project, the cooperativity between two adjacent metals will be used to create new mechanistic pathways that circumvent this issue. The proposal is divided into three distinct work packages focussing on (i) the development of new heterometallic complexes, (ii) their application in stoichiometric vinylic C–H activation and (iii) establishment of catalytic turnover for C–H functionalisation of unactivated olefins. Ultimately the new understanding and new methodology will be applied to the production of vinyl-alkoxysilanes, high-demand and industrial relevant polymer building blocks, from C–H functionalisation of ethylene. Successful realisation of this proposal will provide the fellow with additional know-how in bimetallic chemistry, C–H activation, and catalysis, expanding his skill set beyond his expertise in organometallic and main group chemistry. Additional experience and training in aspects of leadership, teaching and management will complement the fellow’s education to a degree of professional maturity, making him highly competitive for independent funding and positions in academia.


**Keywords:** Bimetallic Chemistry, Vinylic C
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Raising summer energy poverty awareness to reduce cooling needs'.

assistant: **Concept**

Eurostat data reveals that the 11% of the total population of the European Union is unable to keep their home adequately warm. Caused by low household income, high energy bills, and low dwelling energy efficiency, energy poverty has traditionally been associated with the inability of households to meet their heating needs during winter. However, up to the 19% of households declared not being comfortably cool in summer. Nine of the 10 warmest years have occurred since 2005, with the last five years comprising the five hottest. Not to mention this 2019 June has been the hottest on record. Climate change is increasing both the severity and frequency of extreme hot weather and heat waves and in dense urban areas, these heatwave episodes will be combined with the Urban Heat Island (UHI) effect, worsening city centres temperatures which will negatively impact human health and wellbeing. Thus, cooling needs and overheating risk need to be incorporated into the energy poverty equation. The project COOLtoRISE aims to reduce summer energy poverty incidence among European households improving their indoor thermal habitability conditions and reducing their energy needs during the hot season, which will decrease their exposure to heat and heat-related health risks. Not all households have an air conditioning system and it is known that energy poor households make a restrictive use of heating and cooling as they cannot afford associated energy bills. However, raising awareness on summer energy poverty and implementing actions to mitigate it will have a double benefit on European households. First, heat exposure of energy poor households will be reduced by increasing indoor thermal conditions, which will decrease in their risk to suffer heat related diseases. Second, raising summer en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Catalytic Methods for Sustainable Synthesis. A Merged Experimental and Computational Approach' (CATMEC) targeting Horizon 2020.

assistant: **Abstract**

CATMEC is a multi-partner European Joint Doctorate (EJD) Programme offering research training in state-of-the-art sustainable chemical synthesis, catalysis, computational chemistry and bioactive molecule design on both traditional and non-traditional (eg flow) platforms. This Doctoral Training Programme integrates complementary, interdisciplinary and intersectoral training and together with enhanced European mobility through planned secondments of researchers, will contribute to EU policy objectives in scientific training and degree assessment.The researchers will be supervised and mentored by internationally recognised experts and have access to state-of-the-art equipment. Hands-on training will be supplemented by formal training courses in relevant and related fields, and a wide variety of complementary training courses, workshops and seminars. The training of researchers will benefit from secondments to industrial partners, gaining exposure to commercial and complementary environments.Overall, it is anticipated that the CATMEC project will provide Early Stage Researchers (ESRs) with an outstanding training experience, through extensive technical and complementary skills development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Voltage Control of Chiral Spin Structures'.

assistant: **Objectives**

This project will develop a new way to manipulate chiral spin structures such as skyrmions using voltages. Building on the expertise of the fellow in voltage control of magnetism in multiferroic heterostructures, this project uses the unique Spin-Polarised Low Energy Electron Microscope (SPLEEM, in Berkeley) to characterize chiral spin structures in tailored multiferroic heterostructures. By studying (in Leeds) the effects of voltage control on current-driven skyrmion motion in these heterostructures, V-ChiralSpin aims to establish a new, technologically relevant, research area.Representing digital data with magnetic skyrmions offers a promising route to reduce the vast energy consumption and carbon footprint associated with current information technologies. Skyrmion sizes can be in the nanometre range and controlling them with voltage will reduce or eliminate the need for power-hungry electric currents or magnetic fields. The approach will be to manipulate chiral spin textures in tailored epitaxial multilayers via interfacial strain transfer from ferroelectric and piezoelectric substrates. The mechanisms coupling micromagnetic phenomena to voltage signals will be determined through SPLEEM imaging, micromagnetic simulation, and current-driven transport measurements as a function of voltage-controlled strain. Beyond transport properties, we will explore the use of voltage signals to write and delete skyrmions and other spin textures. The fellow will become an expert in the technique of SPLEEM, in the field of chiral spin structures, and in magneto-transport measurements. This fellowship will build and strengthen networks of researchers that will benefit both the fellow and the team members in the hosts. Leeds will benefit from knowledge transfer through the fellow of exp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'DIstributed colLaboratories Infrastructure on Grid ENabled Technology 4 Science'.

assistant: **Concept**

The main objective of this project is to deploy the e-Infrastructures built so far by the EGEE and DILIGENT projects so that they address the needs of several new scientific communities affiliated with the broad disciplines of Environmental Monitoring and Fishery Resource Management. These e-Infrastructures, which offer mechanisms that concurrently exploit networks, grids, and data in a seamless fashion, will enable scientific communities to operate within a coherent pan-European model, regardless of the location of their research facilities. The project will progressively consolidate and expand these open e-Infrastructures to better address the needs of the two major target disciplines (which have challenging differences but also interesting commonalities). Thousands of scientists will obtain increasingly more facilities for creating Virtual Research Environments based on shared computation, storage, and generic service resources offered by EGEE and DILIGENT at a European level, as well as on data and domain-specific service resources offered by large international organizations, such as ESA, FAO, and CGIAR. The envisioned D4Science e-Infrastructure will have a multiplicative benefit to many scientific fields and will also act as a catalyst for the kind of cooperation and cross-fertilization among multiple communities that is necessary for addressing many grand challenges of science and society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Clinical studies on the precursor condition monoclonal gammopathy of undetermined significance - with focus on complications and prognosis' (2007-2013).

assistant: **Concept**

Multiple myeloma (MM) is an incurable hematological malignancy characterized by an M-protein shown in electrophoresis of the blood. Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant asymptomatic condition in which an individual has an M-protein, but no underlying malignancy. MGUS is present in 5-10% of the elderly and precedes all cases of MM, however, not all MGUS patients will progress to MM. An accurate method to predict which patients will progress to MM and related diseases is lacking. Thrombotic issues have recently become a major clinical problem in MM. In addition, we have found that individuals with MGUS have an increased risk of both venous and arterial thrombosis. The underlying mechanisms for the thrombosis risk in MM and MGUS patients remain unknown.In this research project, we will study the well-defined, population-based AGES-RS, a longitudinal cohort study of 5,764 men and women in Iceland who have been screened with extensive clinical, laboratory and radiological examinations with focus on cardiovascular risk profile and diseases, bone disease, as well as all clinical events during follow-up. We will screen all individuals in the AGES-RS study for M-protein. The overall aims of the study proposal are to analyse morbidity and mortality among individuals with and without MGUS. We will then compare specific outcomes in individuals with M-protein (MGUS patients) versus those without. We aim to determine; what is the survival pattern for MGUS patients, what risk factors for malignant transformation (to MM or other malignancies) can be determined, and what risk factors for cardiovascular and bone disease do MGUS patients carry? By improving the prognostic models for MGUS we hope to be able to define high and low risk patients. Our re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The population biology of drug resistance: Key principles for a more sustainable use of drugs' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The evolution of drug resistance and its control represents a considerable challenge in very different biological contexts ranging from pesticide resistance in agriculture to antimicrobial resistance in clinical settings and even extends beyond infectious pathogens, as resistance also evolves in cancer chemotherapy. Naturally, the recommendations for the optimal use of drugs to minimise resistance differ for different biological contexts. In some cases, similar strategies for vastly different pathogens or biological contexts are recommended, whereas in other cases opposing strategies for similar pathogens are advised. To which extent these discrepancies in treatment recommendations are attributable to specific properties of the pathogen, the host, or the general biological context is currently unclear. The aim of this proposal is to develop an integrative population biological framework for the evolution of resistance and its control. To this end we will develop mathematical models of resistance evolution in viruses, bacteria, parasites, cancer and fungal plant pathogens. Developing detailed population biological models that account for the specific biology of these ¿pathogens¿ as well as the specific context of the application of drugs will allow us to identify those aspects that are common between different biological contexts and those aspects that are specific to the pathogen, the host or the drug. Moreover, working simultaneously on resistance evolution in these different biological contexts will facilitate the translation of findings between fields of research that to date have remained largely separate. We seek to bridge these fields and integrate insight to develop a broad conceptual framework with which to address the ever-growing problem of sustainable drug us
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Personal Information and Knowledge Organiser Network' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

The PIKON Project will develop an integrated Information and Knowledge Management Environment that supports personal information and knowledge management needs and enables effective sharing of information and knowledge in the extended/virtual enterprise.The system will comprise:- An ontology and case-based method for information and knowledge management;- A personal information and knowledge organiser;- An enterprise cognitive network with semantic navigability;- The solution will include thematic features and spaces for the exchange of ideas and creative activity and cater for teleworkers and flexible teams;- The solution combines both organisational and technical perspectives which have equal weight.