RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'European Curation of Astromaterials Returned from the Exploration of Space' (EURO-CARES).

assistant: **Concept**

Sample return missions (SRMs) are a critical next step in our exploration of the Solar System and are identified as strategic missions by international space agencies. Europe has a very strong legacy in the curation and research of precious extraterrestrial materials. To maintain European leadership and ensure high-level involvement in future SRMs, a dedicated European Sample Curation Facility (ESCF) to receive and curate returned samples from the Moon, asteroids and Mars, is of critical importance.Euro-CARES will focus on 5 key themes for developing a ESCF:o Planetary Protection- protocols and methods for future SRMso Instrumentation and Analytical Methods- in the fields of cosmo/geochemistry and bioscienceso Facilities and Infrastructures- to curate sensitive extraterrestrial or biological materialso Analogue Materials- that are most appropriate and can be used in ‘end to end’ SRM planningo Portable Receiving Technologies- used to move samples whilst retaining  scientific integrity and bio-containment (for Mars samples)Using the 5 key themes Euro-CARES will:1) Evaluate and critically assess the state of the art within Europe and internationally to identify critical requirements for the ESCF2) Determine and verify European readiness levels to identify where investment is required and opportunities for European leadership in scientific and engineering fields related to curating extraterrestrial samples3) Engage with scientific, industrial, governmental and public stakeholders through community workshops, conferences, publications and educational opportunities4) Deliver recommendations and roadmaps defining the steps necessary to deliver a ESCF to ensure high-level involvement in future ESA and international SRMsEuro-CARES comprises a team of scientists and engineers fro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Harvesting out-of-equilibrium forces for molecular control' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Numerous biological processes harvest out-of-equilibrium forces for transport, sensing, signaling and more. For example, pumping of ions is performed within fluctuating pores that are believed to facilitate transport. The nature of these forces is extremely diverse, from electrical driving to thermodynamic or chemical driving. The ability to describe nonequilibrium states is critical to understand a broad range of biological processes but remains extremely challenging as appropriate thermodynamic concepts have only recently been introduced and are still scarce . The MolecularControl project aims at developing theoretical tools that can be widely applied to out-of-equilibrium soft matter problems. I will use these tools to address more specificially systems relevant to health issues or sustainable energy.In this context, I will develop two theoretical frameworks in the USA. The first will address the dynamics of ions in confinement (electrochemical driving) and will be used to describe the blockage mechanism of a specific neuronal ion channel called NMDA. The second will address the fast growth of molecular crystals via screw dislocations (kinetic and thermodynamic driving) and will be applied to the growth of L-cystine crystals, involved in the formation of kidney stones, a major health issue. Back to Europe with this added value of mastering numerous tools to control molecular assembly and ionic transport in nonequilibrium systems, I will use them to study (a) ion current fluctuations in confinement and between electrodes for applications in individual ionic sensing, advanced capacitive electrode design and blue energy generation and (b) molecular assembly in a more realistic kidney representation, in particular under flow.  This project represents a unique opportunity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'An Integrated Computational and Experimental Approach to Rapid Synthesis of Highly Selective Dual-Targeted HDAC/CK2, MMP2/CK2 Inhibitors' (DUALITY), addressing dissemination and exploitation.

assistant: **Impact**

Traditional drug design strategy based on a single target has serious difficulties in developing new therapies for diseases such as cancer.Cancer is a very complex multi-genetic disease that involves multiple crosstalks between signaling networks. The use of cocktails of various anticancer agents interfering with different mechanisms has been the standard treatment to prevent the problems of resistance.An alternative approach is to design multi-target modulators, directed to different disease mechanisms. That is the approach we have chosen for this project, where we seek to design, synthesize and evaluate new dual agents based on the inhibition of three enzymes involved in the development and progression of tumor processes: HDAC1, CK2 and MMP2.CK2 is a serine / threonine kinase that is constitutively active and essential for cell viability. Its proliferative and anti-apoptotic properties create a favorable cellular environment for tumor progression and maintenance and, therefore, constitutes an interesting target for the treatment of cancer.Acetylation/deacetylation of histones is one of the epigenetic mechanisms that regulates gene expression. HDACs (histone deacetylases) remove acetyl groups from histones, inducing condensation of chromatin and, therefore, the repression of gene transcription. For this reason, they are considered key targets to reverse aberrant epigenetic changes associated with cancer.Matrix metalloproteinases (MMPs), also called matrixins are another family of Zn-dependent enzymes. Our research group has extensive experience in the design and synthesis of inhibitors of MMP2 provided with high activity and, more importantly, high selectivity over other metalloproteinases. The design of multi-target modulators will be carried out making use of computa
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ERA-Net for research programmes on rare diseases' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

There are at least 6000 to 7000 distinct rare diseases, the great majority of them being of genetic origin. Although individually rare, taken together, rare diseases affect at least 20 million of persons in Europe. They represent a major issue in health care since a large percentage of these diseases lead to a significant decrease of life expectancy, and most of them cause chronic illness with a large impact on quality of life and the health care system.Therefore further research on rare diseases is badly needed but is hampered by lack of resources at several levels.(1) Few scientists work on one specific disease.(2) There are few patients scattered over a large geographic area, causing difficulties to gather cohorts required for studies.(3) Usually existing databases and material collections are local, small, and not accessible or standardised.(4) Diseases often have complex clinical phenotypes and require interdisciplinary approaches to treatment and interdisciplinary cooperation for research.Due to the small number of patients affected by a specific rare disease and fragmentation of research, efforts in each individual European country are obviously limited in objectives and power. Therefore rare diseases are a prime example of a research area that could strongly profit from coordination on a transnational scale. The European research area should be enabled to realize its potential by reorganizing and combining scientific expertise, research infrastructure, well defined patient cohorts and biological material. Nine partners have thus decided to join their efforts to overcome the inherent difficulties of research on rare diseases. The general goal E-Rare is to coordinate existing programmes and to prepare joint and strategic activities to overcome some of the limitati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transcriptional regulation of gene expression during cell differentiation and oncogenic transformation', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

While the molecular mechanisms underlying transcriptional activation have been disected to a large extent, transcriptional repression remains poorly understood. To further our knowledge about the mechanisms of transcriptional repression I have been using two molecular models: 1) the retinoblastoma protein (Rb), a key regulator of cell cycle and 2) ZEB proteins (ZEB1/deltaEF1 and ZEB2/SIP1), an emerging family of transcription factors that regulates development and cell differentiation. ZEB proteins bind to a subset of E box sequences in the promoter region of target genes to repress gene expression in several tissues.In the present research proposal I intend to further dissect the mechanisms of transcriptional repression to gain understanding not only on the role of repression during cell differentiation in physiological conditions but, and more importantly, during pathological processes such as cancer. The lines of work proposed hereafter are: 1) study the regulation of the TGFbeta/BMP signalling pathway by ZEB proteins. 2) characterize how ZEB proteins repress gene expression through modifications of the chromatin structure and 3) further our understanding of the ZEB proteins in cell differentiation and malignant transformation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cognitive Collaboration for Teaming' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

In a fast-evolving aeronautical environment (increase in environmental and technological complexity, pilot shortage), positioning a roadmap towards more autonomous flights through Single Pilot Operations (SPO) is a serious Human Factors challenge. Two main strategies towards autonomy are possible today: progressive crew reduction and Urban Air Mobility expansion (UAM drones). Co2Team proposes a crew reduction strategy assisted by cognitive computing to be more competitive versus the Urban Air Mobility strategy. Our objectives are based on three principles:•The gradual design of a cognitive system enabling an intelligent pilot/system shared authority. A strategy of continuous progression enabling the gradual introduction of an “intelligent” system in the cockpit that can learn first passively from “listening” to all the data so as to “learn” the logics of piloting, and then enable hints and suggestions. Once approved, such system could assist pilot’s operations.•An in-depth analysis of all tasks and knowledge necessary for pilots to perform their duties and determine what should remain in the authority of the pilot and what should be delegated to the system, using an iterative validation methodology.•The possibility to work in parallel for technological improvements of UAM systems. Trained Artificial Intelligence with pilot know-how and airmanship (in our SPO/SPIC roadmap) will be a potential intelligence of future drone systems as an added value versus UAM systems.Co2Team project propose firstly a study of what are the Human “real” tasks and knowledge that should be given last to the system and promote those for a SPO/SPIC cockpit. Such differentiation can only be done with expert pilots (Deutsche Lufthansa), experts in human factors in aeronautics and cognitive technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Amphiro en-Gage: Technology for a Smart and Sustainable Use of Hot Water' under Horizon 2020.

assistant: **Concept**

Product: Amphiro has developed the first energy-autarkic, micro-mechatronic modules that measure, communicate and display hot water consumption in real-time and at the point of use. The modules are powered by water flow, fit to virtually every water outlet and can be retrofitted by end-users or integrated by faucets OEMs. The patented technology helps to monitor personal energy and water use, motivates a sustainable behavior and allows faucet OMEs to add digital features to their products.Value to the customer: The first derived product, a consumption feedback-device for showers, has been piloted in 3500 households for the Swiss Federal Office of Energy and the Public Utilities Board (Singapore). It achieves average savings of 440 kWh of heat energy and 7500 l of water per household and year, pays for itself in less than 9 months and earns the user 110 EUR per year thereafter. The pilot study results were named Highlight in Nature Energy.Target customers: Amphiro will address a niche market of environmentally aware and technology affine customers (11% of households), supply products to efficiency campaigns and deliver components for the digitalization of drinking water systems. Lead customers: Amphiro won several large pilot customers, incl. utility PWN (NL), ewz (CH), Public Utilities Board (SG), Melbourne Water (AU), Alicante (ES), plus 9 hotels in Europe.Feasibility assessment: Core objective of this project is to empirically investigate by means of actual sales tests the market feasibility of digital services that accompany the modules and probe four variations of a business model, empirically determine market size and first target segment and derive a well-founded business plan for phase 2.European/global dimension: The mid- to long-term objective is to reach a mar
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'High Resolution, Reduced Energy Flexible Electronics for Enhanced Brain-Spine Interfaces (REFLEX)'.

assistant: **Innovation**

Emerging bioelectronic medical devices, such as brain-spine interfaces (BSI), are improving treatments of the pathophysiological processes at the root of sensorimotor and cognitive disorders. Despite the emerging success of BSIs, the biological and electrophysiological mechanisms underlying treatments remain poorly understood. A significant barrier to their description is the lack of minimally invasive BSIs for real-time, closed-loop monitoring of electrophysiological markers involved in the stabilization and regeneration of neural pathways. REFLEX seeks to overcome the power and packaging barriers that have held back real-time monitoring of neural pathways by leveraging two innovative technologies: (1) the picojoule/bit energy efficiency of wireless backscatter communication and (2) the conformable, compatible circuit boards. REFLEX will enable high spatial and temporal resolution monitoring of neural pathways by providing up to 16 channels for electrophysiological recording at up to 20 kSamples/sec with 16-bit resolution per channel (≥5Mbps total data rate) at <2 mW of total power consumption for recording. By incorporating a low power LED for optogenetic stimulation of neurons, REFLEX will test the effectiveness of targeted therapies to regenerate damaged neural pathways in the spinal cord. The proposed project aligns with the MSCA mission by facilitating the two-way transfer of knowledge in material science, electrical engineering, and neuroscience between the host and the applicant. It combines the applicant’s expertise in wireless backscatter communications and electronic instrumentation with the host laboratory’s expertise in conformable electrode design and interdisciplinary breakthroughs in implantable systems. Through hands-on research, formal training, and ne
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Prevention of sanitary risks linked to rodents at the rural/peri-urban interface' (RATZOOMAN).

assistant: **Concept**

The rural/peri-urban interface can sustain high rodent populations, increasing the public health risks from zoonosis. The epidemiology of many zoonotic diseases is poorly understood, and management strategies have met with little success. The project will investigate the sanitary risks linked to the proximity of rodents in rural/peri-urban areas of Africa. The disease prevalence and livelihood constraints will be measured for plague, leptospirosis and toxoplasmosis, chosen for their variety of clinical manifestations and transmission routes. Ecological and anthropogenic factors responsible for transmission will be identified and the infection dynamics within the hosts and from the hosts to humans will be studied. GIS-based predictive and simulative tools will be developed for modelling transmission risks and the subsequent testing of cost-effective and sustainable control strategies aimed at reducing the sanitary risk associated with zoonosis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'OPtimization of a Thermal energy Storage system with integrated Steam Generator' (OPTS).

assistant: **Concept**

OPTS project aims at developing a new Thermal Energy Storage (TES) system based on single tank configuration using stratifying Molten Salts (MS, Sodium/Potassium Nitrates 60/40 w/w) as heat storage medium at 550°C maximum temperature, integrated with a Steam Generator (SG), to provide efficient, reliable and economic energy storage for the next generation of trough and tower plants.The three-year experimental program will be focused to the full development of the integrated system (TES-SG) up to demonstration level. The SG, with natural recirculation of the MS, can be either positioned directly into the tank (Pool-type) or  as an external shell-and-tube once-through SG (Loop-type) with piping system and pump.Since the objective is to develop a new TES-SG concept for large-scale CSP plants, i.e. 50 MWe, the experimental concept has to be verified in a relevant scale (at least 12.5 MWth), maintaining the same main thermo-fluid-dynamic parameters as the full scale system. This test section will be designed, built, and tested. Basic experimental, modelling and engineering activities will be carried out to support the design and optimization of the proposed technology. These activities include assessment of MS heat transport properties under relevant representative conditions for the TES-SG system.Moreover, design, optimization and cost-benefit assessment for a full-scale TES-SG system (125 MWth/50MWe) will be done in the framework of the OPTS project coupled with a CSP (tower or trough) plant.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Data-Driven and User-Centered Content Moderation' (DEDUCE) targeting Horizon Europe.

assistant: **Abstract**

Online platforms apply moderation interventions (MIs) to mitigate misbehavior. Today, MIs are one-size-fits-all, meaning that each intervention is applied in the same way for all users. However, not all users are the same, as they have diverse demographics, ideologies, and personalities. This naive approach to content moderation is platform-centered and neglects user differences. Moreover, content moderation resembles art more than science. The design of MIs is based on common sense and intuition, and progress is sought via trial-and-error rather than via a rigorous scientific process. The inevitable consequence is that current MIs have variable effectiveness, are highly unreliable, and fall short of the moderation needs.The ambitious goal of DEDUCE is to initiate a paradigm-shift in content moderation, by building the theoretical and methodological foundations to move from intuition-driven approaches enforced via one-size-fits-all MIs, to science-driven strategies grounded on personalized moderation interventions (PMIs). We will develop causal methods and indicators to evaluate the effectiveness and fairness of current content moderation practices. Then, we will study how user characteristics influence the outcomes of moderation. Finally, we will leverage the acquired knowledge to design and evaluate PMIs, a first-of-its-kind endeavor. Our data-driven approach will enable us to evaluate in advance the effects of many MIs (what-if analyses) and to plan ahead their application, rather than to assess and correct afterwards. The high-gain nature of DEDUCE is evident, as it will open new directions of research (e.g., the design of PMIs), while also providing major practical and social benefits. Our results will yield groundbreaking advancements in the theory and practice of