RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'KNOWLEDGEABLE COMPREHENSIVE AND FULLY INTEGRATED SMART SOLUTION FOR RESILIENT, SUSTAINABLE AND OPTIMIZED TRANSPORT OPERATIONS', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The overreaching goal of KEYSTONE is to support the development of a sustainable, efficient, and safe transport system, allowing enforcement authorities to access data for the purpose of checking compliance with rules applied in the transport of goods and passengers. The aim is to tailor standardised digital solutions that can be used from several realities to standardize the transport system. To demonstrate the validity of the solutions proposed, an app will be developed so that two highly diverse pilots can prove the efficiency of the KEYSTONE’s innovation. Using the gained experience to develop a seamless, interoperable, and intermodal digital transport ecosystem that can be replicated at European leveThe overreaching goal of KEYSTONE is to support the development of a sustainable, efficient and safe transport system. Allowing enforcement authorities to access data for the purpose of checking compliance with rules applying in the transport of goods and passengers. The aim is to tailor standardised digital solutions that can be used from several realities in order to standardize the transport system. In order to demonstrate the validity of the solutions proposed, an app will be developed so that two highly diverse pilots can prove the efficiency of the KEYSTONE’s innovation. Using the gained experience to develop a seamless, interoperable, and intermodal digital transport eco-system that can be replicated at European level. The KEYSTONE digital solutions consists of standardised APIs for data and information sharing between transport enforcement authorities and logistics operators based on a federated approach allowing to reduce the costs of logistics thanks to more efficient operations and interoperability, to reduce the impact on the environment thanks to data shari
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Role of the mitochondrial Translocator Protein (mTSPO) in Brain Cellular Physiology: a Neglected Pathway in Signalling and Self-conservation Mechanisms' (2007-2013) under Seventh Framework.

assistant: **Objectives**

Balanced energy homeostasis and correct functioning of regulatory processes are the basis of cellular health. The impaired interplay between these is thus responsible for the pathology of tissues especially for those undergoing stress and unable to regenerate such as the Brain. An exhaustive comprehension of the physiology of molecules intimately involved in these phenomena is therefore essential both to increase our understanding of Brain fundamental physiology and to delineate novel approaches to tackle pathologies at their origin. The mitochondrial Translocator Protein (mTSPO) is one of these molecules as critically located on the outer membrane of the mitochondrion and in close association with the multi-functional protein Voltage Dependent Anion Channel (VDAC). mTSPO is increases during brain inflammation but, in spite of this, its cell biology and the underlying events associated to changes in its expression are still obscure.The research program I propose here aims to elucidate this pathway for mitochondrial and cellular physiology and so finalize an understating on a neglected molecule upon which the homeostasis of the cell dependents.We will address the mTSPO role in mitochondrial and cell metabolism and to the processes guarding cell integrity such as Apoptosis and Autophagy; we will do so by ascertaining how mTSPO ratio of expression with that of VDAC defines the signalling of Ca2+, dynamics of the Reactive Oxygen Species (ROS), ATP rationing and Redox State. How modifications in ROS impinge on downstream kinases will be also determined. Pharmacological tools to modulate mTSPO activity will be employed as a further means of investigation and finally the relation between mTSPO/VDAC ratio of expression and pathological behaviour of tissues will be scrutinized.T
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Condensed Heat - Optimization and scaling up of an energy efficient, long-during biomass condensation boiler with curved heat exchanger' (C-Heat), addressing dissemination and exploitation.

assistant: **Impact**

BioCurve and Quintín laid the groundwork for a new generation of condensing boilers. We have developed a biomass condensing boiler that has been internationally awarded, which led C-Heat to surpass from far the current state of art, in terms of performance, ripping design and price. By taking advantage of the identified market opportunity, C-Heat will contribute to the growth of BioCurve and Quintín with a turnover of 6.7Mio. € and 20 new jobs by 2022 introducing an innovative technology powered by renewable organic sources and available in a broad range of power outputs.Former technologies for domestic heating are either unsuitable for moving forward towards a sustainable energy model across EU, or insufficient in terms of energy efficiency. In order to overcome these issues, Biocurve and Quintin have developed a cutting edge biomass boiler capable of working under condensing conditions. Thanks to a novel spiral heat exchanger that enhances 50% the exchange surface, C-Heat compact solution shows > 100% energy efficiency by capturing almost all latent heat of condensation of water vapor in the exhaust stream. In addition, an accurate control of the system enables low temperature applications (i.e. radiant floors). Until now, C-Heat has passed rigorous technical assessments, procuring international quality standards certifications. Also, several units are well operating in real condition, installed in private apartments since 2013. Therefore, an appropriate technology readiness level together with the unmet needs invite us to establish an ambitious but achievable aim for the next years: To become an international reference in the bio heating domestic and tertiary segments as well as the small scale industry. In fact, it does lead us to believe that C-Heat is potentially
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Polymers in Secondary Organic Aerosols'.

assistant: **Concept**

Recent experiments have shown that organic material in secondary organic aerosols (SOA) can polymerize leading to new high molecular weight compounds with mass up to 1000 Da. Such polymers are of concern regarding their potential adverse health effects and impact on air quality and climate. High molecular weight compounds have been found in ambient aerosols but their origin is unknown and their identification rudimentary. This project aims to apply and develop different sophisticated analytical methods to m easure high molecular weight compounds of this SOA polymer and to characterize its chemical and physical bulk parameters. In a joint measurement campaign at a smog chamber a combined effort will be undertaken to identify and characterize these polymers pro duced from different precursors which dominate in anthropogenic and biogenic emission sources. Simultaneously, these SOA polymers will be applied on-line to cell culture systems which are representative for the inner surface of airways and/or alveoli. Part icle-cell interactions will be investigated by ultrastructural and biochemical analyses. In addition, the cell cultures will be tested for the presence of reactive oxygen species and/or (pro)inflammatory proteins. A subset of the analytical tools will be d eployed to analyse ambient samples of which selected samples will be applied to cell cultures. The project will provide a basis to assess the risk of this new category of airborne contaminants to health as well as the importance of these polymers and the p olymerization process with respect to air quality and climate change. Since European research groups are at the forefront of this new scientific development, POLYSOA will significantly raise and strengthen the capabilities and scientific competitiveness of th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European focus on red biotechnology with China' (2002-2006) under Sixth Framework.

assistant: **Objectives**

The overall aim is to respond to the ever-growing scientific and commercial importance of China for the EU in the life sciences, genomics and biotechnology for the health field. The increasing interest for future resaerch collaboration will also build on the collaborative EU-China networks, good relations and achievements established during a previous EFBIC programme. The focus is on developing joint EU-China research and encouraging the participation of Chinese scientists in EU Framework Programme consortia and the participation of the European research scientists in the MOST (China Ministry of Science & Technology) research programmes, 863 and 973. It will be carried out by the EFB(European Federation of Biotechnology) in partnership with the CNCBD (China National Centre for Biotechnology Development) in close conjunction with and financial co-sponsorship of the European Commision and the MOST. The following actions are planned: *Three information and Partnering Fora that will provide information on topics of shared interest in EU framework and Chinese research programmes * Four research workshops on topics of urgent common interest will be organised on subjects chosen by teh SSMB board * Reciprocal exchanges and visits will enable Chinese scientists to travel to Europe in preparation for each Framework Programme Call for proposals, and EU and Chinese scientists to travel to each other's centres and conferences to detaile the basis for cooperation * Support for partner search and proposal writing will provide support and advice to European and Chinese who wish to enter into joint partnerships * Informationon and promotion of EU-China cooperation and funding opportunities will make available information on research activities and funding opportunities in EU and China a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Biomedicalizing Gender. The Globalization of Sexual Science and the Redefinition of Gender Roles in Poland' (BIOMEDGEN).

assistant: **Innovation**

Since 1989, gender roles have been in a state of continual flux and redefinition in Poland, reflective of ideological battles between the re-emergent Catholic Church, newly proclaimed scientific sex experts, and feminists and LGBT activists. This project is based on ethnographic fieldwork and analyses of written sources, and explores the relationship between scientific knowledge of sexuality and the construction of gender roles and stereotypes in contemporary Poland. I ask how the field of sexual science in particular has developed as a product of transnational flows of scientific knowledge (influence of North American knowledge of sexuality) , and in response to local debates about gender and sexuality. I seek to understand how the proliferation of discourses about sexuality that engage scientific language and ideas shapes gender roles in Poland. I will develop a theoretical framework based in medical anthropology and globalisation studies; study Polish and North American scientific knowledge of sexuality in order to track the sources of the knowledge referred to by my Polish informants; and examine cultural processes associated with the formation of local scientific knowledge of sexuality. The fellowship at Harvard University and the University of Warsaw will expand my field of expertise (medical anthropology, anthropology of globalisation in teaching and research; ethnographic fieldwork techniques and ethics) and facilitate obtaining habilitation (an obligatory next step after PhD in the Polish higher education system, required for conducting and supervising independent research projects and supervising PhD students) by allowing me collect data and develop theoretical framework for the habilitation book. Moreover, the fellowship will help to deepen the collaboration
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a european measurement method for noise characterisation of domestic fuel oil and gas boilers (BOILERNOISE)' under Fifth Framework.

assistant: **Concept**

The Boilernoise project concerns fuel oil and gas boilers used for hot water central heating of residential and small commercial buildings. It seeks to develop a European measurement method for their noise characterization, in order to get a reliable value of their sound power level and to help CEN to develop new measurement standards, in relationship with the implementation of Construction products directive (89/106/EEC).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'International Conference on Research Infrastructures 2014' (ICRI2014).

assistant: **Concept**

Following the series of the European Conferences on Research Infrastructures (ECRI) from years 2000-2010 under the corresponding rotating presidency of the European Union and the International Conference on Research Infrastructures during the Danish Presidency of the European Union in 2012 (ICRI 2012), the Greek Presidency of the Union in cooperation with the European Commission [Directorate-General for Research & Innovation (DG RTD) and Directorate-General for Communications Networks, Content & Technology (DG CNECT)] will organise the next major International Conference on Research infrastructures in 2014 (ICRI 2014). The conference will take place 2-4 April 2014 in Athens, Greece.ICRI is a conference on Research Infrastructures; the latter play an increasingly important role in the advancement of knowledge and technology. They are a key instrument in bringing together a wide diversity of stakeholders to look for solutions to many of the challenges society is facing today. RIs offer unique research services to users from different countries, attract young people to science, and help to shape scientific communities.The objectives of the conference are to highlight the essential role of global research infrastructures in addressing grand challenges at all scales: national, regional, European and global scale; to reflect on needs, development and operation of global research infrastructures at national, regional, European and international level; and topresent the main characteristics of global research infrastructures and identify the challenges and drivers for collaboration at international level.This proposal lays out a comprehensive plan for the organisation, management and dissemination of the ICRI2014 conference.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Scalable Quantum computing with Light and Atoms'.

assistant: **Objectives**

The goal of SCALA is the realisation of a scalable quantum computer, by using individually controlled atoms, ions and photons in order to encode, store, process and transmit qubits.This long-term goal is divided into two specific objectives, achievable during the project duration:A) Realisation of interconnected quantum gates and quantum wiring elements, which are required as building blocks of a general purpose quantum computer.B) Realisation of first approaches of operational" quantum computing, which include(i) systems able to perform small-scale quantum algorithms, such as error correction(ii) special-purpose quantum processors, such as quantum simulators, and(iii) entanglement-assisted metrology.In order to achieve these objectives, the IP teams will use all the tools and methods of atomic, molecular and optical physics. Experiments will involve strings of individual ions in Paul or Penning traps, arrays of neutral atoms stored in dipole traps, optical lattices or micro-magnetic traps ("atom chips"), and a great variety of cavity QED techniques. In addition, broader theoretical studies will explore the path towards a scalable general-purpose quantum computer. The objectives A and B are actually associated with two ways for achieving scalability: a "bottom-up" route consisting of developing elementary registers, gates and processors, and then networking them, and a "top-down" route starting with large, strongly interconnected, distributed systems, such as atoms in optical lattices, which are natural candidates for quantum simulators.Combining both approaches is a guiding principle in SCALA, and would be a major achievement for the future of quantum computers. SCALA will be organized to optimise flows of information between the participating teams. The results will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Analyzing the functions of AP-1 in liver carcinogenesis' to be submitted under Sixth Framework.

assistant: **Abstract**

Hepatocellular carcinoma (HCC) causes about 500,000 deaths worldwide each year and is the leading cause of cancer mortality in some parts of the world. Although the pathogens for HOC are quite clear, the molecular mechanisms through which they induce HOC development still need to be clarified. AP-1 genes encode transcription factors, which possibly play important roles in many cancers, including HOC.Until now, little is known about their functions in liver carcinogenesis. In this respect, I will investigate AP-1 functions in genotoxiccarcinogen induced HCC using conditional knock-out mice. This study will focus on c-Jun, c-Fos and p53pathways and their interactive functions in liver cancer, especially in the early stages of carcinogenesis. Molecules responsible f or dysregulated apoptosis and proliferation will be identified by molecular, immunohistological and micro-array analyses.This project will uncover novel insights into the molecular mechanisms involved in HCC, which may provide new avenues for the development of diagnostic and drug targets in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'RNA-protein Nanostructures for Synthetic Biology'.

assistant: **Objectives**

Synthetic biology aims at re-engineering organisms for practical applications by designing novel biomolecular components, networks, and pathways. The field is expected to lead to cheaper drugs, sustainable fuel production, efficient diagnosis and targeted therapies for diseases. However, a major obstacle to achieve these goals is our limited ability to rationally design biomolecular structure and function. By contrast, the field of DNA nanotechnology has so far demonstrated an unprecedented ability to design and self-assemble well-defined molecular shapes, although the production method of thermal annealing is not compatible with cells. We have recently demonstrated a breakthrough method, called RNA origami, which allows the design of RNA molecules that fold into well-defined nanoscale shapes during their synthesis by an RNA polymerase. In this proposal I aim at extending this technology to produce RNA-protein nanostructures and at demonstrating their application in synthetic biology. My primary scientific hypothesis is that understanding the folding process during synthesis will help us to design nanostructures that can be produced in cells. I will design a general RNA-protein architecture that is compatible with folding during synthesis. I will investigate folding kinetics to be able to design and program the dynamical folding process. Based on this, RNA-protein nanostructures will be designed, expressed in cells, and verified, for the formation of the desired shapes. We will develop new functionalities by both rational design and selection approaches with the aim of obtaining multivalent-binding and switching properties. Finally, the functional RNA-protein nanostructures will be applied in proof-of-concept experiments to demonstrate efficient, multivalent targeting o