RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Seawater desalination by innovative solar-powered membrane-distillation system' under Sixth Framework.

assistant: **Concept**

Despite the advantages of solar membrane distillation (MD) systems very few experimental systems have been developed as opposed to the mature technologies solar PV-driven RO and solar distillation. Therefore, main objective of MEDESOL Project is the development of an environmentally friendly improved-cost desalination technology to fresh water supply in arid and semi-arid regions in EU and Third Countries based on solar MD.The layout involves the innovative concept of multistage MD in order to minimize specific energy and membrane area required and also to substantially reduce the brine generation. The aim of this work was to evaluate the technical feasibility of producing potable water from seawater by integrating several membrane distillation module s (Multi-step Membrane Distillation System). The aim is to develop systems for a capacity ranging from 0.5 to 50m3/day. Technical simplicity, long maintenance-free operation periods and high-quality potable water output are the very important aims which will enable successful application of the systems that are based in membrane distillation.The heat source will proceed from an advanced compound parabolic solar concentrator, developed to the specific concentration ratio to achieve the specific needed range of temperatures (90ÂºC) and the seawater heater will include the development of an advanced non-fouling surface coatings to avoid the deposit formation (i.e. scaling) at such temperature. Laboratory tests under defined testing conditions of all components are very important for the preparation of successful field tests under real conditions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Lubrication system by oil mist'.

assistant: **Objectives**

The main objective of the project is to introduce and sell an innovative technology for the lubrication of industrial machinery on the global market.This technology consists of a new lubrication system by means of oil mist. Compared with existing systems (Venturi and Vortex), it is much more efficient (90% reduction of energy consumption while in operation), more respectful of the environment (based on an analysis of the life cycle) and may also be used in systems that require high viscosity lubrication oils, thus replacing high energy-consuming technology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Common Metadata for Climate Modelling Digital Repositories' (METAFOR) under Seventh Framework.

assistant: **Objectives**

Climate science plays an increasingly important role for European policy-makers and private sector companies. Basic research and development of effective strategies to mitigate climate change and deal with its impact on society are required, involving a wide range of experts from multiple disciplines. These expert need to access climate data, in particular data from model projections for the next decades and centuries, and to assess the suitability of that data for their purposes. Currently, even if large repositories of climate data are accessible, these repositories are poorly connected and described. The data is therefore difficult to understand, compare and exploit because there is no common information paradigm.<br/>The main objective of METAFOR is to define a Common Information Model (CIM) that describes in a standard way climate data and the models that produce the data. METAFOR will build on existing metadata (data describing data) currently used in existing data repositories and address issues like metadata fragmentation, gaps, or duplication. In close interaction with related initiatives at the international level, METAFOR will propose solutions to identify, access and use the climate data in these repositories. To support the adoption of the CIM, METAFOR will build CIM-based tools and services, allowing specific data and models to be found and compared between holdings at partner sites. METAFOR will therefore optimise the way climate data infrastructures are used to store knowledge, thereby adding value to primary research data for an increasingly wide range of stakeholders.<br/>METAFOR will take the first step in doing for climate data what search engines have done for the Internet: it will put users of climate data in touch with the information they need. S
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ocular models for ageing and age-related diseases' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

- Search for factors and/or conditions preventing or postponing age-related changes in ocular tissues. - To find out whether normal and/or enhanced levels of alphaA-crystallin promote resistance against conditions which might cause damage to eye tissue and/or its constituents and whether already distorted eye tissue has a diminished level of the protecting protein. In summary it will be investigated whether alphaA-crystallin plays a key role in the protection of eye tissues. Such studies in tissue culture and in situ will be a first step in the finding of those factors which are involved in prolongation of the lifespan of highly differentiated organs as the eye. - The finding of effective treatments for age-related and other degenerative retinal disorders by examination of the normal retina as well as the retina of humans and animals with well characterized degenerations and by developing retinal cell transplantation procedures. - Good descriptions of the different nosological entities. - Factors determining differentiation, structure and survival of retinal cell transplants as well as vital components of photoreceptor differntiation. - Molecular characterization of K+ channels in the human lens and ageing effects on the channel properties. - The examination of the permeation properties of sclera; a profile of the age related functional, biochemical and structural changes in the sclera will be constructed.The eye contains a variety of tissues of which the time course of their ageing processes differs considerably. Studying these processes in the different ocular tissues might lead to understanding of the pathogenesis of a number of age-related eye diseases such as: primary open angle glaucoma or macular dystrophy of the retina; particularly if compared with slow rate ag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'A DUAL gRNA system for functional assessment of ENhancers in Pluripotency' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Enhancers are cis-regulatory genomic regions that can modulate gene expression in a cell type-specific and time-controlled manner to regulate cellular behaviour. ChIP-seq and RNA-seq technologies have allowed genome-wide identification of potential enhancers based on the correlation among specific chromatin marks, transcription factor biding sites and gene expression. However, strategies to validate their function are still limited. Recently, it has been demonstrated that the CRISPR/Cas9 genome editing technology can be used to delete large genomic regions at high frequency by co-transfection of two guide RNAs (gRNAs) targeting collinear genomic sites and subsequent NHEJ-mediated repair. Nevertheless, this system is limited to individual tests. Here we aim to generate a novel lentiviral dual-gRNA expression system that enables large scale functional enhancer screening. The candidate will apply this dual-gRNA expression system to generate custom libraries that will allow the functional identification and subsequent validation of essential enhancers for the maintenance of mouse Embryonic Stem (mES) cell identity. This technology will provide a comprehensive view of the function of enhancers within their genomic context and will enable for the first time the performance of systematic, genetic forward enhancer screens.


**Keywords:** Stem Cells, Enhancers, CRISPR, Cas9, Forward Genetic Screens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Step-compliant data interface for numeric controls' (STEP-NC).

assistant: **Concept**

The project has developed the necessary prototype infrastructure (software applications and hardware modules  RFID Readers/Labels) providing a set of value added electronic services to consumers and advanced marketing facilities to retailers and suppliers. Thus, the main outcome of MyGROCER can be summarized in the following that have been deployed and tested upon real conditions in Greece (ATLANTIC Super Market) and Finland (TRADEKA Super Market), during the Trials:(A)An in-store application that allows the consumers to manage the products of their shopping cart through a touch screen device while they are in a supermarket, using RFID technology to automatic identify the in  out products (RFID labels are placed in the product packages, while RFID Readers embedded in the shopping cart are also used). Additionally the application allows the consumer to receive targeted promotions based on his/ her profile (purchasing habits, preferences)(B)An in-store navigation application that allows the consumers to perform virtual trails through a hand-held device, while they are in the store.(C)A smart home application used by the consumer at his/her home in order to monitor the consumers inventory based on replenishment rules that are defined by the consumer. RFID technology is also used in that case to retrieve information about the in  out products placed on the shelves.(D)An on the move application that allows the consumers to manage their automatic generated home shopping lists.(E)A consumer behaviour analysis and promotions management tool that allows the retailers and the suppliers to identify consumers purchasing habits and apply targeted promotions.(F)The prototype RFID infrastructure used for the in store as well as the at home applications to identify products (R
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quick Challenge-driven, Human-centered Co-Creation mechanism for INDUStry-Academia Collaborations' under Horizon Europe.

assistant: **Concept**

INDUSAC’s main objective is to develop and validate a state-of-the-art, Industry Academia collaboration (IAC) mechanism for quick, challenge-driven, human-centred co-creation. Its aim is to build upon pre-existing IAC mechanisms such as EIT KICs and to facilitate a simple, user-friendly co-creation process that allows to develop solutions that clearly address the needs and interests of companies, students, and researchers in the EU, with special attention to widening and associated countries. Of a highly digitalised nature, our project will pilot the mechanism’s two main components: a methodology developed by applying human-centred design principles and an online platform aimed at connecting stakeholders from the industry-academia ecosystem and at supporting them throughout their co-creation journey. The INDUSAC methodology will provide the guidance and tools needed to power the process, whilst the platform will stand as a networking space for stakeholders to connect, as well as a co-creation arena to develop joint solutions. Through the experience of supporting at least 300 transnational co-creation teams throughout project lifetime, the INDUSAC mechanism and its two key components will be successively improved until project end, delivering a tested mechanism ready for replication and upskilling. It is expected for INDUSAC to also create a dynamic community of industry-academia stakeholders, including at least 1000 companies, 3000 students and 300 researchers by project end. The INDUSAC counts with a strong interdisciplinary, cross-sectorial and geographically balanced partnership that counts with the needed expertise and network to achieve our project’s goals.


**Keywords:** industry-academia collaboration,  online platform,  challenge-based quick competitions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Advanced exhaust gas recuperator technology for aero-engine applications'.

assistant: **Objectives**

Fuel-efficient aero-engines must be developed in the future in order to reduce the environmental damage produced by ever increasing airline traffic. The desired savings in specific fuel consumption and reduction of CO2 by 20% in 10 years however must not be achieved at the expense of increasing NOx emissions. With currently existing technology, the only concept capable of fulfilling simultaneous reductions of both CO2 and NOx is the aero-engines concept of an Intercooled Recuperative Aeroengine (IRA). A key component of this type of propulsion is the exhaust gas recuperator (hex). The primary goal of the present proposal is to develop a realistic design concept of a hex for application in the IRA with regard to efficiency, operational life weight and cost. A complete design and construction process will be carried out, manufacturing aspects will be considered, and flow investigations necessary to determine the optimum hex arrangement will be undertaken. The resultant hex will enable a realistic assessment of the benefits of an IRA-engine in terms of CO2 and NOx reduction. Based on the design developed in this project, a hex matrix element for the EEFA-LSIP project will be manufactured.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'The molecular basis and genetic control of local gene co-expression and its impact in human disease'.

assistant: **Innovation**

The genetic makeup intrinsic to each person shapes their particular traits, disease susceptibilities and treatment effectiveness, making understanding the functional impact of genetic variants one of the most pursued challenges in genetics research. Genome-wide association studies (GWAS) have so far associated >10,000 genetic variants with disease, with expression quantitative trait loci (eQTL) studies adamant in linking some of these disease variants to causal genes. Yet, understanding a variant’s molecular link to disease is still a major challenge, given that most are found in the genome’s non-coding regions, act only in specific tissues and may affect several genes. Recent studies revealed that neighbouring genes are often co-expressed – forming co-expression domains (CODs) – potentially regulated by shared regulatory variants, yet, this has been ignored in eQTL and GWAS studies. This project aims to investigate how local gene co-expression is achieved and regulated by genetic variants, and their impact on human disease. For this, I propose a novel genome-wide framework to detect human CODs and their regulatory variants (cod-QTLs) using transcriptomic profiles across hundreds of genotyped individuals. The mechanisms through which variants affect the expression of several genes will be discovered through causality inference and molecular characterisation using state-of-the-art datasets (e.g. Hi-C, promoter-enhancer maps). Notably, CODs’ tissue-specificity will be studied using gene expression across 53 human tissues and the co-expression variation across 120 individuals will be assessed using a cutting-edge dataset of single-cell RNA-seq. The impact of cod-QTLs on dozens of societal-relevant diseases will be determined by colocalization analysis with GWAS hits from t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Innovation for Climate chAnge mitigation: a study of energy R&d, its Uncertain effectiveness and Spillovers' to be submitted under Seventh Framework.

assistant: **Abstract**

Much has been said on how to reduce current anthropogenic emissions with the aid of a portfolio of existing technologies. However, stabilization of atmospheric concentrations of greenhouse gasses to a safe level requires that over time net emissions fall to zero. There is only one way that this can be achieved in a manner that is acceptable to the majority of the world's citizens: through some kind of technological revolution. To bring about such an innovation breakthrough extensive research and development (R&D) investments will be required. This will be specifically important for Europe, given its leading position in climate negotiations and in the light of the Lisbon Agenda. Technological breakthroughs will have an essential role in tackling the competitiveness issue that has gained great relevance lately in the policy debate. On top of this, technological transfers to Developing Countries could be the turning key to solve the logjam affecting international negotiations.The current proposal aims at producing an unprecedented analysis of energy-related innovation mechanisms; understanding the role of R&D investments and of inter countries and inter sector spillovers; disentangling the role of public and private R&D investments; incorporating in the analysis the uncertainty that inevitably affects the successfulness of R&D programs; simulating optimal responses using an integrated assessment model. The analysis will make use of empirical analysis of existing databases and will collect new data. Expert elicitation methods will be used in order to better assess technology-specific uncertain effectiveness of R&D programs. Simulation models will be used to produce quantitative grounded results. Summa of the analyses will be projections for optimal public and private energy
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Remote Accessibility to Diabetes Management and Therapy in Operational healthcare Networks' (REACTION).

assistant: **Concept**

The REACTION project will develop an integrated approach to improved long term management of diabetes; continuous blood glucose monitoring, clinical monitoring and intervention strategies, monitoring and predicting related disease indicators, complemented by education on life style factors such as obesity and exercise and, ultimately, automated closed-loop delivery of insulin.The REACTION platform will feature an interoperable peer-to-peer communication platform based on a (SoA) service oriented architecture – all functionalities, including devices, are represented as services and applications consisting of a series of services orchestrated to perform a desired workflow. The REACTION platform also features a Model Drive Application Development environment based on extensive use of dynamic ontologies and advanced Data Management capabilities with algorithms for clinical assessment and rule-based data processing.The intelligent, interoperable platform developed by REACTION will provide integrated, professional, management and therapy services to diabetes patients in different healthcare regimes across Europe, including 1) professional decision support for in-hospital environments, 2) safety monitoring for dosage and compliance, 3) long term management of outpatients in clinical schemes, 4) care of acute diabetic conditions and 5) support for self management and life-style changes for diabetic patients.A range of REACTION services will be developed targeted to insulin-dependent type 1 diabetic patients. The services aim to improve continuous blood glucose monitoring (CGM) and insulin therapy, by both basal dose adjustment and contextualised glycaemic control based on patient activity, nutrition, stress level, etc. Decision support will assist healthcare professionals, pati