RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Structural and mechanistic studies of RNA-guided and RNA-targeting antiviral defense pathways', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The evolutionary pressures exerted by viruses on their host cells constitute a major force that drives the evolution of cellular antiviral mechanisms. The proposed research is motivated by our interest in the roles of protein-RNA interactions in both prokaryotic and eukaryotic antiviral pathways and will proceed in two directions. The first project stems from our current work on the CRISPR pathway, a recently discovered RNA-guided adaptive defense mechanism in bacteria and archaea that silences mobile genetic elements such as viruses (bacteriophages) and plasmids. CRISPR systems rely on short RNAs (crRNAs) that associate with CRISPR-associated (Cas) proteins and function as sequence-specific guides in the detection and destruction of invading nucleic acids. To obtain molecular insights into the mechanisms of crRNA-guided interference, we will pursue structural and functional studies of DNA-targeting ribonuceoprotein complexes from type II and III CRISPR systems. Our work will shed light on the function of these systems in microbial pathogenesis and provide a framework for the informed engineering of RNA-guided gene targeting technologies. The second proposed research direction centres on RNA-targeting antiviral strategies employed by the human innate immune system. Here, our work will focus on structural studies of major interferon-induced effector proteins, initially examining the allosteric activation mechanism of RNase L and subsequently focusing on other antiviral nucleases and RNA helicases, as well as mechanisms by which RNA viruses evade the innate immune response of the host. In our investigations, we plan to approach these questions using an integrated strategy combining structural biology, biochemistry and biophysics with cell-based functional studies. Togethe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Design, synthesis and structure-properties relationships of liquid crystals' (1998-2002).

assistant: **Concept**

Marie Curie Fellowships, Liquid Crystal & Advanced Materials Research Group, Department of Chemistry, University of Hull, Hull, UK Applications are sought for 6-12 month Postgraduate Research Fellowships, which form part of an EU funded Marie Curie project to be located at the Centre of Organic and Biological Chemistry at the Department of Chemistry. The successful applicants will joint the Liquid Crystal Group in Hull. Research in the Chemistry Department of the University of Hull is currently ranked 11^th out of approx. 100 UK universities. The liquid crystal Group is one of the largest of it kind in Europe, Most of LC devices used currently contain materials devised initially at Hull. The city of Hull (~300.000 inhabitants) is situated in the North-East of England at the East Yorkshire coast, approx. 300 km north of London. Applications from researchers with an interest in supra-molecular chemistry, self-assembly systems, liquid crystals, organic-inorganic hybrids, and dendrimers are encouraged. A background in liquid crystal research is welcome but not necessary. Successful candidates will have obtained a good undergraduate degree and must be an EU national or EU associated state national registered for a PhD degree at a university outside the UK and for a topic which compliments the liquid crystal research at Hull. To increase the number of women in science applications from women are encouraged. A stipend of 1200 Euros per month will be offered to a successful candidate. Applicants should send a CV including the names and addresses of two referees to: Dr. G. H. Mehl, Department of Chemistry, Hull University, Hull HU6 7RX, UK, Tel.(++44) 1482 465590,Fax. (++44) 1482 466411, Email G.H.Mehl@chem.hull.ac.uk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The dynamics and rheology of self-assembled empty liquids: from patchy toy models to anisotropic realistic systems' (DELTAS).

assistant: **Concept**

In this project I plan to investigate by means of numerical simulations the dynamics and rheology of low-densityequilibrium gels made of limited-valence building blocks. I will start with simple toy models of patchy particlesand then add complexity in the form of inner degrees of freedom by investigating systems that undergo a hierarchicalself-assembly process. Examples of such systems are recently synthesised DNA constructs and telechelic star polymers.The novelty of DELTAS lies in the focus put on the role of the internal flexibility as a tool to tune the dynamicsand the rheology of equilibrium gels. Indeed, the possibility of fine-tuning the structure of these materialslend themselves well to many applications, ranging from medicine to material science. The project goes one step further by proposing to investigate the kinetics, dynamics and mechanical properties of these systems in the framework of (flexible) patchy systems. The usage of simple toy models will grant a better understanding of thephenomenology of these systems. In addition, the realistic systems I plan to investigate will, on one hand, establish a stronger link between theory and numerical simulations and experiments and, on the other hand, provide a testing ground for the results obtained with toy models.


**Keywords:** dynamics, rheology, gels, physical gels, hydrodynamics, patchy particles, colloids, patchy colloids, DNA, polymers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Moving into the genomics of marine biodiversity'.

assistant: **Objectives**

The Station Biologique de Roscoff (SBR) is a research and training center in marine biology and oceanography, jointly operated by the Centre National de la Recherche Scientifique and by the Université Pierre -et-Marie Curie. The SBR missions are to promote research and academic education on biology of marine organisms and ecosystem. The SBR has adopted a leading stance in promoting genomics approaches on marine models and ecosystems. This EST programme is thus designed to provide European pre-doctoral fello ws with advanced, interdisciplinary training programme in marine biology, with an emphasis on genomics, genetics and structural biology. The SBR will also host short stay scientists who want to be trained in such areas as sequencing and transcriptomics/bio informatics and proteomics/3-D structure determination. Based both on research and technology training in the Institute¿s research groups and core services and on an integrated curriculum of specific courses and workshops, ESTeam will accelerate the socia l and professional integration of the Marie Curie fellows at the SBR and reinforce their professionalism and competitiveness as future European researchers. Practically, this will be achieved as follows: and) make sure that the incoming young researchers i n the SBR are rapidly integrated, both scientifically and culturally, with a special attention to gender issues, and make them to grasp as soon as possible the full extent of the scientific opportunities which are offered at the marine station and through its collaborative networks; é) give a high attention to their research projects, including through external mentoring; 3) provide them with a complementary training to overcome the obstacles to mobility and to raise their professional profile; 4) give them a ge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Lubricating Cartilage: exploring the relation between lubrication and gene-regulation to alleviate osteoarthritis' to be submitted under Horizon 2020.

assistant: **Abstract**

Can we exploit insights from the remarkably lubricated surfaces of articular cartilage, to create lubricants that may alleviate osteoarthritis (OA), the most widespread joint disease, affecting millions? These, succinctly, are the challenges of the present proposal. They are driven by our recent finding that lubrication of destabilised joints leads to changes in gene-regulation of the cartilage-embedded chondrocytes to protect against development of the disease. OA alleviation is known to arise through orthopedically suppressing shear-stresses on the cartilage, and a central premise of this project is that, by reducing friction at the articulating cartilage through suitable lubrication, we may achieve the same beneficial effect on the disease. The objectives of this project are to better understand the origins of cartilage boundary lubrication through examination of friction-reduction by its main molecular components, and exploit that understanding to create lubricants that, on intra-articular injection, will lubricate cartilage sufficiently well to achieve alleviation of OA via gene regulation. The project will examine, via both nanotribometric and macroscopic measurements, how the main molecular species implicated in cartilage lubrication, lipids, hyaluronan and lubricin, and their combinations, act together to form optimally lubricating boundary layers on model surfaces as well as on excised cartilage. Based on this, we shall develop suitable materials to lubricate cartilage in joints, using mouse models. Lubricants will further be optimized with respect to their retention in the joint and cartilage targeting, both in model studies and in vivo. The effect of the lubricants in regulating gene expression, in reducing pain and cartilage degradation, and in promoting ste
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Selective sustainable hydrodeoxygenation of bioaromatics' (2021-2027).

assistant: **Concept**

The depletion of fossil resources and the requirement to significantly reduce our CO2 footprint made the production of chemicals from non-edible biorenewable feedstocks an intensive contemporary research field. Remarkably, amongst the bioderived chemicals available, bioaromatics are still scarce. A typical feature of biobased platform molecules is their high oxygen content, which is in sharp contrast with current base chemicals obtained via a classical petrochemical approach. While petrochemical industry requires efficient and selective oxidation protocols, biorenewables on the other hand require the reverse, i.e. efficient and selective reduction reactions, necessitating new reaction development. Chemical and (bio)catalytic processes on biorenewable resources (e.g. wood, cloves, gallnuts) deliver a variety of oxygenated arenes (guaiacols, syringols, catechols, pyrogallols). Hydrodeoxygenation (HDO) reactions on these biobased arene building blocks can give access to functional chemicals suitable for the chemical industry. Though extensively researched, selective HDO on these oxygenated arenes is still poorly developed. Therefore, the main objective of this proposal is to develop selective HDO in catechols, guaiacols, pyrogallols, and syringols. Our approach involves sustainable activation of Ar-OH and Ar- (OH)2 with a renewable and cheap reactant, and subsequent reduction with a renewable reductant. As catalysts readily available and cheap base metals will be explored rather than scarce and expensive precious transition metals. Both homogeneous and heterogeneous catalysis will be evaluated.


**Keywords:** Biorenewable chemicals, sustainable chemistry, bioaromatics, reduction, phenols, anisoles, carbonate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Spanish Network of Mobility Centres' demonstrating excellence, impact and implementation quality for a Sixth Framework call.

assistant: **Abstract**

The proposal goes in parallel with the two initiatives launched by the European Commission: The creation of the Researcher's Mobility Portal and the setting up of the European Network of Mobility Centres (ERAMORE). The objective of these new instruments is to remove obstacles to the mobility of researchers to encourage more mobile human resources and to enhance the attractiveness of Europe to foreign researchers. The initiatives will serve at offering researchers and their families with accurate information and assistance on their activity, when moving to another country. This work programme aims at the implementation of the Network of Mobility Centres in Spain, the ultimate goal is to encourage more mobile human resources and to enhance the attractiveness of Spain to foreign researchers. The work programme has been designed bearing in mind the results of the mapping exercise of existing services carried out throughout Spain, the characteristics of the administration in Spain' and the integration of the national network in ERAMORE Spain is a federal-type of state with seventeen regional governments having their own competencies in several areas such as education (including university studies) and health. Research competencies still remain with the central government. In addition to this most of the regional governments have their own R&D regional plans and calls for proposals.'
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A New Blueprint for Chemical Synthesis via Metal-Catalyzed C H Bond Functionalization' (METCHACT) under Seventh Framework.

assistant: **Objectives**

Synthesis is a fundamental area of science that is crucial to advances in medicine and materials - fields that directly impact modern society. The increasing challenges that our society presents has raised the demands on synthesis to provide new molecules that can perturb biological function or provide a new physical property. This fellowship aims to provide solutions to these problems by developing pioneering synthesis blueprints for how chemists can make any molecule in an efficient, rapid and  green  fashion. In particular, direct benefits of this research will be realized in the treatment of disease.The bond forming processes that underline our ability to make molecules, large or small, depends on the manipulation of pre-functionalized molecules (compounds that need to be prepared through additional synthetic steps). However, the most common type of chemical bond in almost all organic molecules is the C H bond. Usually, all but a few of these C H bonds are considered as inert and only useful in synthesis if they are in the vicinity of a one of these activating functional groups. To a synthetic chemist, permitting the use of any C H bond as a potential functional group would be like giving them a key to a new world Discovery of new chemical reactivity would lead to new reactions; comprised into a new tool kit for synthetic chemists, this would provide the basis for a molecule-building blueprint that would challenge synthetic dogma. Furthermore, using the traditionally  inert  C H bond as a versatile functional group would save synthesis time, make synthesis  greener , and hence more efficient and cost effective. Therefore, to be able to introduce a general blueprint for chemical synthesis based using any C H bond as a versatile functional group would be a truly parad
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fast rAdio technologieS for uninterrupTed TRAin to traCKside communicationS' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The urbanization trends of the urban and suburban metropolitan areas have increased exponentially the demand for high-capacity rail infrastructure, which require interoperable systems and services, with high standards of safety and reliability.At the same time, the railway technological infrastructure and the related services require a high level of innovation, especially in the field of telecommunication systems and rail control. In recent years, several different rail control technologies have been focused upon to increase the track capacity, improve the overall operational efficiency and ensure safer railway traffic. Among these innovative technologies applied in EU are the Communication-Based Train Control systems (CBTC) and the European Rail Traffic Management System (ERTMS).In this context, the wireless telecommunication networks are playing an increasingly important role thanks to functional and maintenance features and installation time: by virtue of their robustness and high redundancy they can convey simultaneously data traffic for automatic train control and transfer massively security and passengers control information.However, the wireless coverage of the existing railway technological infrastructure does not ensure full operational standards, capacity and robustness required for a large-scale use in support of the railway signaling.FAST-TRACKS project proposes the development and commercialization of a low cost telecommunication system, which addresses the main problems faced at present in the integration of a traditional Wi-Fi system within the railway technological infrastructure. The project aims at covering a functional gap in the railway radio telecommunication infrastructure. The information provided in this proposal is based on the technological and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Electric solar wind Sail doctors' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Electric solar wind Sail doctors (E-Sailors) is a challenge-based Doctoral Network that aims to bring Electric solar wind sail (E-sail) from low Earth orbit (LEO) demonstration missions to the operational environment of the solar wind. It is delivered by 8 universities in cooperation with FMI, where E-sail was invented, and 4 SMEs. E-sail is a highly innovative and potentially disruptive propellantless propulsion system. An operational E-sail consists of hair-thin and kilometres-long wires, or tethers, which are charged at a high voltage creating an electrostatic sheath (electric sail) which deflects solar wind particles and generates the propulsive effect in interplanetary environment. Successful and rapid development and deployment of the technology will ensure EU's leadership in the exploration and exploitation of deep space, the next commercial space frontier. To advance E-sail, we will implement 15 PhD projects to:1) Develop mission and experiment designs for demonstrating the E-sail in solar wind and for utilizing the E-sail for visiting small Solar System bodies and potential interstellar objects; 2) Design state-of-the-art solar wind propulsion systems and their components; 3) Design nanospacecraft (~15 kg) platform and subsystems for control, navigation, communications and operations; 4) Establish an open source research community for E-sail modelling and mission design software.In doing the above, we will achieve the following training objectives for our doctoral candidates: 1) Equip them with core scientific skills and specialised knowledge in designing experiments for demonstrating space technologies and developing space missions; 2) Provide them with a wide range of transferrable skills, such as Open Science and FAIR, communicating science to public, ad