RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Multiwavelet video compression', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

In this project we aim to develop a radical, new class of video compression algorithms which will form the basis of the standards of the next century. Our approach will be to use the multiwavelet transform in space and time with a space-time extension of the zero-tree algorithm used in image compression. The advantages over MPEG of our approach include higher compression, better quality, and much lower complexity and hardware cost.Video and image coder/decoders (codecs) are one most important enabling technology for the digital multimedia revolution. At the moment the MPEG and JPEG standards have opened the door to this revolution, however in the future users will demand higher levels of compression with higher quality.As the MPEG standards have progressed over time the changes made have been evolutionary rather than revolutionary. Each new standard has produced better compression and quality, however the basic technology used in each (Motion Estimation, DCT transform etc) is the same. Given the 30 years of research carried over the years on these algorithms, the gains achievable in the future will be small compared to their cost.At the end the first stage of this project we expect to have produced a video codec, which is significantly better in compression and quality than MPEG4, yet is simpler and cheaper to implement in hardware. At the end of the second stage we expect to have designed and fabricated a prototype VLSI processor implementing the algorithm.The wavelet transform, zero-tree approach introduced by the proposer has already had a revolutionary effect for image compression, it is our aim in this project to do the same for video compression.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The first non-surgical repair for Pelvic Organ Prolapse' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Pelvic Organ Prolapse (POP) affects nearly 50% of women over 40 years old globally. 89% of the cases seek treatment for symptomatic early stage prolapse. Despite the high prevalence and the progression of POP over time, patients currently cannot be offered a repair solution until the condition worsens enough for surgical intervention. However, the surgical interventions of prolapse have several side effects like prolonged recovery, pelvic pain and relapses of POP. Escala Medical has developed a minimally invasive and incision-free repair intervention for early-stage POP repair - Apyx. Apyx is the first medical device for treating early stage prolapse, regaining quality of life and prevention of prolapse deterioration for the vast majority, currently un-addressed, POP sufferers. The EIC project will finalize the development of Apyx, conduct clinical trials, and support scale-up and commercialization activities.


**Keywords:** Pelvic organ prolapse,pelvic floor disorder,Women’s Health,FemTech,Patient care
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Cracow research centre of molecular catalysis and soft matter chemistry' to be submitted under Fifth Framework.

assistant: **Abstract**

The main objective of the proposal is to establish the Centre of Excellence (CoE) in the Institute of Catalysis and Surface Chemistry (ICSC). Formation of the CoE will strengthen the Institute unique role of a leading research centre in molecular catalysis, surface chemistry and colloid science in Central Europe and integrate it within European Research Area through the increased networking with leading scientific institutions. The project will allow to broaden the Centre's area of research, increase the collaboration of the Institute with European scientific centres, extend the educational offer of the International PhD Studies in ICSC and attract young researchers to work in the Institute to develop their scientific skills. It will enhance chances of successful participation in 6th FP. It will also increase links with industrial and social environment of the country and will contribute to dissemination of knowledge in society.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Structural Vaccinology to drive the design and optimization of protein antigens for a multicomponent vaccine against Staphylococcus aureus' (SV-STAPH-VAX) under Seventh Framework.

assistant: **Objectives**

Staphylococcus aureus is one of the most important bacterial pathogens causing human death and disease on a global scale (Klevens, 2007). The rapid generation of antibiotic resistance, coupled with the frequency and severity of staphylococcal disease, underlie the increasing medical need to combat S. aureus infections. As an alternative to inadequate antibiotic therapies, we are dedicating efforts to develop a preventative staphylococcal vaccine.Previously, multiple capsular polysaccharides, or single antigenic proteins have been tested as staphylococcal vaccines, but all have failed in clinical trials, likely for reasons that we have reviewed (Bagnoli, 2012). Expert opinion now advocates a multi-protein vaccine strategy that could raise a broadly protective immune response, neutralizing pathogenic virulence factors like surface lipoproteins and families of secreted pore-forming toxins. To this end, we used Reverse Vaccinology to identify protective staphylococcal antigens that generated immunity in mice against diverse clinical S. aureus isolates (see Mishra, 2012). Additional candidates have been highlighted in the literature, including the leukotoxin LukED which targets the human CCR5 receptor (Alonzo, 2013).To ensure the development of efficacious and safe vaccine antigens, the research project proposes the structure-based optimization of two candidate antigens: (i) an antigen engineered from the Csa protein family that we recently discovered and characterized (Schluepen, 2013) and (ii) an engineered detoxified leukotoxin-E antigen. We recently determined and released the crystal structures of two Csa proteins and of LukE. As pioneers of Structural Vaccinology (Scarselli, 2011; Dormitzer, 2012), we are now ideally poised to exploit this high-resolution information w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Large area uniform industry compatible perovskite solar cell technology' (LUMINOSITY) targeting Horizon Europe.

assistant: **Abstract**

LUMINOSITY is an industry driven project aimed at leveraging the flexible perovskite solar cells (PSC) technology to commercially relevant production scales, using established industrial processes. The objective of the project is to demonstrate roll-to-roll (R2R) processed photovoltaic (PV) module with power conversion efficiency (PCE) of >20% at an area of >900 cm2, and thus overcome the efficiency gap between lab-scale and fab-scale processed devices, elevating the TRL up to 7. One of the unique selling points of this work is the commercial substrate foil based on aluminum with fluorinated-tin-oxide (FTO) electrode layer, which is an intellectual property of HyET Solar, the end user in the consortium. By using this substrate foil, LUMINOSITY will alleviate the bottlenecks related to limited process window of typical polymer substrate foils – such as high quality nickel oxide charge transport layer deposition (requires 300ºC thermal process) – to reach high stability, efficiency, and lower environmental impact, while keeping the flexibility. The consortium encompasses the full value chain from research and technology developers, equipment manufacturers, suppliers, and industrial end-users. Together, we are well-equipped to surmount the existing challenges that have hindered the widespread adoption of PSC technology. Specifically, LUMINOSITY will achieve operational stability exceeding 20 years that rivals the lifetime of current commercial thin film PV technologies, while ensuring economic (0.14 USD/W at R2R production scale) and environmental feasibility (50% lower CO2 foot-print in comparison to c-Si PV), substantiated by comprehensive Life Cycle and Techno-economic Analysis.LUMINOSITY will fast-track the market uptake of flexible perovskite PV technology and thus en
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Adhesion switches in cancer and development: from in vivo to synthetic biology' (ADHESWITCHES).

assistant: **Innovation**

Integrins are transmembrane cell adhesion receptors controlling cell proliferation and migration. Our objective is to gain fundamentally novel mechanistic insight into the emerging new roles of integrins in cancer and to generate a road map of integrin dependent pathways critical in mammary gland development and integrin signalling thus opening new targets for therapeutic interventions. We will combine an in vivo based translational approach with cell and molecular biological studies aiming to identify entirely novel concepts in integrin function using cutting edge techniques and synthetic-biology tools.The specific objectives are:1) Integrin inactivation in branching morphogenesis and cancer invasion. Integrins regulate mammary gland development and cancer invasion but the role of integrin inactivating proteins in these processes is currently completely unknown. We will investigate this using genetically modified mice, ex-vivo organoid models and human tissues with the aim to identify beneficial combinational treatments against cancer invasion.2) Endosomal adhesomes – cross-talk between integrin activity and integrin “inside-in signaling”. We hypothesize that endocytosed active integrins engage in specialized endosomal signaling that governs cell survival especially in cancer. RNAi cell arrays, super-resolution STED imaging and endosomal proteomics will be used to investigate integrin signaling in endosomes.3) Spatio-temporal co-ordination of adhesion and endocytosis. Several cytosolic proteins compete for integrin binding to regulate activation, endocytosis and recycling. Photoactivatable protein-traps and predefined matrix micropatterns will be employed to mechanistically dissect the spatio-temporal dynamics and hierarchy of their recruitment.We will employ innovativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The Cultural Logic of Honor and Social Interaction: A Cross-Cultural Comparison' (HONORLOGIC), addressing dissemination and exploitation.

assistant: **Impact**

Understanding (un)willingness to coordinate with others, to compromise when faced with different choices, or to apologize for transgressions is crucial as these behaviors can act as strong facilitators or inhibitors of important interpersonal processes such as negotiations and coalition building. These behaviors play a major role when individuals from different cultural backgrounds work together to solve disputes or address joint challenges. Yet, we know little about what these behaviors mean in different cultural groups or how they are approached. With HONORLOGIC, I aim to initiate a step-change in our understanding of cultural variation in these important domains of social behavior by providing unique, multimethod, comparative and converging evidence from a wide range of cultural groups. I will answer the question “How do cultural groups that promote honor as a core cultural value approach coordinating with others, reaching compromise, and offering apologies?” by integrating insights from social/cultural psychology, behavioral economics, and anthropology. I will do this by collecting quantitative data using economic games, experiments, and surveys from Spain, Italy, Greece, Turkey, Cyprus, Lebanon, Egypt and Tunisia, as cultural groups where honor has been shown to play a defining role in individuals’ social worlds. I will also run the proposed studies in the US, the UK, Japan and Korea to provide a broader comparative perspective. HONORLOGIC will produce transformative evidence for theories of social interaction and decision making in psychology, economics, and evolutionary science by (a) producing innovative theory and data with an interdisciplinary and multi-method approach, (b) increasing the diversity of the existing evidence pool, (c) testing established theoret
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'LaserTrain' (LT).

assistant: **Innovation**

Anyone who travels by train is familiar with delays. Track contamination such as rust, oil and most notoriously autumn leaves cause the tracks to become slippery. Research  shows that this leads to 75% lower traction and as a result to severe safety issues from the reduced braking ability. Low traction also leads to slipping and sliding wheels creating ‘flat spots’ and damages wheel and track. Launching customer MTA Long Island Rail Road estimates the cost of wheel repairs at €3.000 each and that for a total of 3.307 wheels in 2017. As  for safety issues, in 2017 in the UK 295 trains failed to stop at stations or red lights. The UK infrastructure manager Network Rail shows that slippery tracks cost them an annual €320 million, showing that there is need for a working solution. Laser Tribology B.V. (LPS) has developed the solution: the LaserTrain. Using high-powered laser pulses the slippery contamination layer is vaporized from the track, without heating up or damaging the track. The LaserTrain is a separate wagon that can be pulled by locomotives in any operator’s network. A few dedicated cleaning LaserTrains clean the network between September and March when the contamination layers hinder operations. After three years of R&D, a full in-house simulation and a prototype on live track the system is now ready for a debut in Europe. The system is fully standalone, requires only energy and cleans at 80 km/h, so it blows away the competition in every aspect.In Europe there is a long list of prospects following our development closely, such as Network Rail (UK), Banedanmark (DK), Dutch Railways (NL), Deutsche Bahn (DE) and PKP (PL). To meet their demand, engineering on an 80 km/h LaserTrain has finished. Now it’s time to protect the most vital parts of the IP and make it a h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'VALIDATION OF DEDICATED SHORT-RANGE COMMUNICATIONS' (VASCO), addressing dissemination and exploitation.

assistant: **Impact**

The aim of VASCO is to validate the suitability of a specific technology for the support of road transport and traffic telematics applications such as electronic fee collection, access control or traffic and travel information. Municipal and transport authorities, vehicle fleet owners and car drivers are among the users of the technology which is proposed for European standardization and known as dedicated short-range communication (DSRC). The project will result in the validation of the DSRC equipment of all main European manufacturers. The common standard will enable the applications to be used anywhere in Europe.The main objective of the project is the validation of Dedicated Short-Range Communication (DSRC) proposed for standardization in Europe (CEN TC 278) as suitable technology to support road transport and traffic telematics (RTTT) applications (such as Automatic/Electronic Fee Collection, Access Control, Traffic & Travel Information, Dynamic Route Guidance etc.).Users of DSRC and RTTT applications are organisations such as cities / road authorities, motorway operators, fleet owners as well as car drivers. The needs and requirements of these users will be taken into account by close co-operation with other projects proposed for the 4th framework (e.g. MOVE-IT: Motorway Operators Validate EFC for Interoperable Transport) and analysis of DRIVE II project outcomes and project team results contributing to standardization of RTTT.The project will be based on the emerging standards on the user requirements produced by the applicative working groups and on prENV standards already specified by sub-groups of the DSRC working group 9 of CEN TC 278. The prENV standards will be validated with respect to their correctness, consistency and completeness, and their implementabi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Association of Aquaporin Transmembrane Channels and Influence of their Oligomerization State on the Transport Properties' in the context of a Seventh Framework call.

assistant: **Objectives**

The goals of this proposal are to (i) determine how does the oligomerization state of aquaporin (AQP) transmembrane channels influence the water transport properties of these channels, and to (ii) understand how aquaporins’ association and transport properties change under different lipid composition conditions. The study will be conducted on the human AQP5 aquaporin, whose atomistic high resolution structure has been recently determined. First we will determine the water transport properties of the wildtype tetrameric AQP5 channels from fully atomistic simulations. Then we will compare our results with the corresponding properties we obtain for a single channel in the same lipid bilayer. Second, we will study the association of AQP5 channels in a lipid bilayer closest to its natural environment by describing both the dynamics and the energetics of such associations. Since these processes occur on a mesoscopic timescale, unattainalble from fully atomistic simulations, we will use a coarse-grained model of the AQP5 porins and its surrounding environment. Third, we will investigate the influence of lipid composition on the association of these aquaporins. Fourth, we will compare transport properties of AQP5 channels in various lipids that were studied at the third point. The simulated systems will use fully atomistic models with initial configurations obtained from the coarse-grained simulations. The techniques used in our research proposal are based on free energy profile calculations using well established methods from steered molecular dynamics, as well as new approaches from Monte Carlo based flat-histogram simulations. Our novel approach for studying aquaporins can help us understand better how their association influences their functionality. Furthermore, the propos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Multifunctional Organic-inorganic Elements with Biosensing re-Usability' (MOEBIUS) under Seventh Framework.

assistant: **Objectives**

The main objective of the project is to bring together recent advances in semiconductor nanostructures, organic molecule self-assembling and bio-interfacing to develop a new generation of biosensors for in situ environmental monitoring and life science applications. Tunable electronic material with pores on semiconductors produced by swift heavy ion-track-based patterning forms an attractive foundation for interfacing conventional electronics with bio-active sensor compounds. Nano-sized channels of ion-track based structures modified by metal oxides in combination with a self-assembled layer of organic or bio-organic sensor layer can multiply the response of the device by many orders of magnitude as compared to conventional sensor architecture. Thus the fundamental goals of the project are nanofabrication of such state-of-the-art structures and exploring of the interactions between bio-molecules and novel nanomaterial.To fulfill objectives of the project a multidisciplinary research team is formed. The expertise of the team covers all key areas, including fabrication of the TEMPOS structures; synthesis functional organic and bioorganic molecules and self-assembling of molecular layers; structural and functional (including photo-/electro-activities) characterizations; theoretical ab initio computations. The novel reusable biosensors will allow quantitative analysis of toxins and key biomarkers important for diagnostics of liver deceases with high accuracy and reliability. The industrial partners will complement fundamental research by prototyping the biosensors and testing them in situ, thus ensuring the fast conversion of the results to production technologies.