RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Scalable Structured Micro Illumination Light Engines' (SMILE).

assistant: **Concept**

The SMILE idea is based on the results of FET-Open “ChipScope”, which gave us unique technology skills in the processing of nanoLED arrays. In contrast to the ChipScope’s nanoLEDs for superresolution microscopy, larger SMILE microLEDs arrays can also be used for activating and manipulating chemical or biological reactions. With microLEDs, light intensities can be orders of magnitude higher. Larger dimensions enable hybrid integration with CMOS microelectronics, leading to a full scalability of the microLED platform in terms of number of pixels, intensity, switching speed and cost in a mass production situation. MicroLEDs can also be combined with existing colour converter technology, resulting in substantial flexibility concerning wavelength control. SMILE will develop microLED platforms giving access to an enormous variety of novel applications, when used as “Scalable Structured Micro-Illumination Light Engines” (SMILE). The approach is completely different to conventional structured illumination strategies used today. SMILE workplan includes GaN chip technology, CMOS design, chip-chip hybrid integration and system integration (housing and software). SMILE gives very high priority to market replication, preparing for discussions with future investors by the following approach: an “End-User Board” (EUB) of experts from various applications will discuss requirements to be met and perform SMILE test experiments. Therefore, SMILE prototypes will be made available to the EUB for testing and market validation in at least 5 different Pilot Applications (PA), which have already been chosen for analysing importance, relevance and high market potential: (1) DNA chip fabrication; (2) Maskless photolithography; (3) Optogenetics; (4) High-throughput fluorescence microscopy; (5) Chi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'NeuroRobotics Platform Application to Traction Control for Automotive Industry' (NeuroMotive) targeting Horizon 2020.

assistant: **Abstract**

The work proposed aims at the development of a service in Traction Control for the automotive industry, building upon innovation from the NeuroRobotics Platform (NRP, HBP-SP10). The service will use the platform’s capacity to synthesize sophisticated neural control laws. Controllers developed will be tested on a unique infrastructure, the Siemens Mobility Test Setup (SMTS), which allows physical emulation of a wide range of road conditions for any car connected. This System-in-the-Loop (SyL) setup will support machine learning processes, allowing tuning of the traction controller to a high standard of performance, and provide early control-function validation and performance assessment. The work proposed involves: A limited amount of Technical Work, to connect NRP and SMTS, and develop the required service provision tools, Market Analysis and business plan development for the envisioned service, and a heavy emphasis on Outreach and Engagement of stakeholders and potential interested end-users.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Co-ordinated Programme to identify families with susceptibility to Prostate Cancer' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

The major focus of this study will be to collect families with (a) three or more prostatic cancer cases diagnosed at any age; or (b) two or more affected brothers diagnosed before the age of 65 years. Such families are candidates for carrying an inherited susceptibility predisposing to prostatic and possibly other malignancies. The families will be collected through major clinical urology centres through Europe. This bank of material, both DNA and RNA, will then be available for molecular genetic studies to identify genes predisposing to prostate cancer. The project will initially use genetic linkage analysis to identify genes which contribute to the risk of prostate cancer and to assess the importance of this gene/these genes to familial prostate cancer. DNA markers which are usually based on microsatellite repeats and which are known to have high degrees of polymorphism are typed within the families and tested for co-segregation with the putative prostate cancer susceptibility gene. Evidence for co-segregation is assessed statistically. The analysis will focus on a variety of candidate genes which are known to play a role in either prostate development or in other cancer susceptibility syndromes such as those for the breast cancer syndromes, BRCA1 and BRCA2. Only in the event that none of these turn out to be important would a genome-wide mapping search be initiated. When a gene or more probably a genetic region is identified as being important, we will assess the importance of this region to familial prostate cancer. The other approach will be to examine the importance of genes thought to modify the risk of prostate cancer using a case-control approach. We will collaborate with ongoing studies which are investigating environmental causes of prostate cancer to examine
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of chemical biology tools for the elucidation of protein phosphatase-1 substrates and druggability' (PP1TOOLS).

assistant: **Concept**

Protein serine/threonine phosphatases (PSTPs) are considered undruggable although they are involved in the most prominent post-translational modifications. This is mainly due to an apparent lack of substrate specificity. One important PSTP is protein phosphatase-1 (PP1), a ubiquitous PSTP that is predicted to catalyze about 1/3rd of Ser and Thr dephosphorylations in eukaryotic cells, counteracting hundreds of kinases. PP1 has broad substrate specificity but is restrained in vivo by numerous PP1-interacting proteins functioning for example as substrate-targeting proteins and forming specific holoenzymes with PP1. PP1 holoenzymes play a role in many different diseases such as cancer (counteracting oncogenic kinases), diabetes (insulin release), Alzheimer’s (dephosphorylation of Tau protein) and HIV (viral translation). Currently, there are no chemical modulators available that target PP1 selectively, except that we recently developed the first compound that selectively activates PP1 in intact cells, leading to rapid dephosphorylation of PP1 substrates. The activator does not act on the most closely related protein phosphatase-2A. This proposal aims to generate and apply tools for the investigation of PP1, in part based on our previously developed activator. The tools include selective, photo- and enzymatically releasable chemical inhibitors and activators and semisynthetic proteins, and they will be applied to study PP1–substrate interactions and help identify the correlating interacting proteins. The proposed research will provide long-sought selective chemical tools to study PP1 by applying new concepts of activator and inhibitor design using peptide and small molecule chemistry to an enzyme class that is difficult to be targeted chemically. This research program will c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Dosimetry and Health Effects of Diagnostic Applications of Radiopharmaceuticals with particular emphasis on the use in children and adolescents' in the context of a Seventh Framework call.

assistant: **Objectives**

The aim of this proposal is to provide data on dosimetry and corresponding dose related risks when administering radiopharmaceuticals for diagnostic purposes in children and adults. The composition of the consortium ensures that contacts to other bodies such as the International Commission on Radiological Protection (ICRP), the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine or member state radiation protection agencies are provided in order to obtain up-to-date information on the developments in this field. In addition, data on imaging device-specific parameters and corresponding phantoms will be gathered in order to get information on potential dose reductions with emphasis on paediatric nuclear medicine procedures, and on computed tomography absorbed doses in hybrid scanners. If, as a result of the reviews, the need for additional clinical trials is identified, details for the set-up of such trials will be given. Finally, recommendations for weight-dependent minimum and maximum activities with particular emphasis on paediatric nuclear medicine will be developed. The dissemination of results will be coordinated by the European Institute for Biomedical Imaging Research (EIBIR) and undertaken with the help of the radiation protection authorities in individual member states and the European Association of Nuclear Medicine (EANM).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'A genomics toolbox to enhance business for SMEs in the market of starter cultures and probiotics' (GENOBOX), addressing dissemination and exploitation.

assistant: **Impact**

Fermented food (e.g. cheese, yoghurt, bread, wine) constitute a large part of our diet. They are converted from a substrate (milk, fruits, cereals) by the action of micro-organisms (yeast or lactic acid bacteria). When such starter cultures also exert a health benefit (eg. prevention of diarrhea) they are known as probiotic strains. Throughout the EU starters and probiotic strains are mainly supplied by SMEs to end-users for application in food products.The SMEs compete with a few large companies providing such cultures. The competitive edge of SMEs is at risk in part due to stricter safety rules to be imposed by EFSA. EFSA will demand full genome characterisation to exclude presence of sequences posing a potential health risk (such as virulence factors, antibiotic resistance and toxins) and to allow traceability of distinct strains as proprietary strains are unique. Genome analyses and bio-informatics are not the current core of SMEs in this consortium as they have focus on primarily cost effectiveness.GENOBOX exploits the strength of four SME starter culture companies and probiotic producers in this sector combined with skills and expertise of two renowned RTD performers. The RTD performers will sequence and analyse 48 bacterial strains provided by SMEs and coming from culture collections. A genomics toolbox will be created, allowing every SME to exclusively study the detailed results on their own strains while benefitting from results of the collective. The SMEs will perform in-house experiments and demonstrations to validate the results of the project for optimised production yields. Also workshops will be organised by the RTD performers to develop data-exploitation strategies for the SMEs involved.During this project the SMEs will be able to abide to EFSA ruling, e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Transfer standards for calibration of scanning probe microscopes', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Summary There are now 200 scanning probe microscopes (SPM) installed in Europe and the number is rapidly increasing. This new class of universal 3 coordinate measurement machines, which give direct images of the topography of surfaces in the range 0.1 nm - 100 uM, has many industrial and scientific applications. One very important industrial application is the measurement of micro roughness and micro hardness of surfaces which becomes increasingly important in the motor and tool manufacturing industry but also for advanced integrated circuit manufacturing. However, to be valuable as a measurement instrument the SPM needs to be properly calibrated, a task which is not possible now, if proper traceability to the metre definition is required. The purpose of the project is to produce and certify several sets of transfer standards, which can be used to calibrate the three orthogonal axes x, y) and of scanning probe microscopes (x, y are the two horizontal axes, is the vertical axis). The transfer standards shall have a regular three-dimensional pattern on the surface with known characteristic spacing (called pitch) in the x and y directions and a known step height in the z direction. The pitches and step heights shall cover the range from 3 nm to 30 uM and shall be measured with traceability to the metre definition. With this set of transfer standards any SPM can be calibrated under all measurement conditions. The selected set of artefacts will be calibrated using well accepted techniques. The local variations of pitch and step height over the surface of the transfer standard (the variations should be kept as small as possible) will be determined. The calibration package will include an algorithm for the calculation of the calibration parameters, including the associated unc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A new PV wave making more efficient use of the solar spectrum (FULLSPECTRUM)' (FULLSPECTRUM) under Sixth Framework.

assistant: **Objectives**

The project pursues a better exploitation of the FULL solar SPECTRUM (as requested in the Work Programme) by further developing concepts already scientifically proven but not yet developed and by trying to prove new ones in the search of a breakthrough for the PV technology. More specific objectives are the development of:a) III-V multijunction cells (MJC), b) Solar Thermo-photovoltaic (TPV) converters,c) Intermediate band (IB) materials and cells (IBC),d) Molecular based concepts (MBC) for full PV utilisation of the solar spectrum ande) Manufacturing Technologies for novel concepts including assembling.MJC technology towards 40 % efficiency will be developed using lower cost substrates and high light concentration (up or above 1000 suns). TPV is a concept of high theoretical efficiency limit because the whole energy of all the photons is used in the heating process and because the non-used photons can be feed back to the emitter, therefore assisting in keeping it hot. Small prototypes with sun/gas heated emitters will be developed. In the IBC approach sub-band gap photons are exploited by means of an IB. IB materials will be sought by direct synthesis suggested by material band calculations and using nanotechnology in quantum dot IBCs. In the development of the MBC, topics like the development of two-photon dye cells and the development of a static global (direct and diffuse) light concentrator by means of luminescent multicolour dyes and QDs, with the radiation confined by photon crystals, will be particularly addressed. Manufacturing technologies include using opt electronic assembling techniques and coupling of light to cells with new-optics miniconcentrators.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'On the neural basis of working memory:How the brain retains information in the face of distraction' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Every time we open our eyes, we are bombarded with visual information. At the same time, we need to retain previously observed information to keep track of our goals and whereabouts. How can we remember relevant visual information when we are continuously processing new information? Recent studies have shown that when we have to maintain visual information over a short delay period, our visual system that deals with the initial processing of stimuli is recruited to keep representations active. However, these studies have focused on the mechanisms of remembering visual information in a setting where there is no visual distraction. This obviously does not apply to everyday situations. Although in fundamental science it is necessary to first pinpoint the basic processes underlying complex constructs, we are now ready to move beyond this simplification and investigate more life-like situations. In this project, we will use a combination of functional Magnetic Resonance Imaging (fMRI) and Transcranial Magnetic Stimulation (TMS) to investigate which neural mechanisms are responsible for retaining visual information in the face of distraction. Specifically, we will investigate how remembered, but currently unused items are stored, and in which manner this information is activated for subsequent use. We will use newly developed fMRI analysis techniques to pinpoint the locus and nature of unused representations, and causally confirm these by applying TMS to these regions at specific moments in time. At the end of this project, we will have gained important insight into the neural underpinnings of visual working memory as we use it in daily life. This will provide a basis for understanding and improving the performance of tasks in a highly demanding visual environment. For exampl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Towards the selective hydrodeoxygenation and hydrogenation of levoglucosenone using base metal heterogeneous catalysts modified by atomic layer deposition' (TAILORCAT), addressing dissemination and exploitation.

assistant: **Impact**

Catalytic technology has advanced markedly throughout the 20th century, refining the catalytic processes that provide us with fuels and base chemicals. Presently some important challenges in catalyst development are:a) Fine tuning of the catalysts on the atomic level therewith creating unprecedented control over the performance of catalystsb) The use of base metals, countering the increasing cost and scarcity of the group VIII metalsc) Efficient and short conversion routes from biomass to industrial/commodity chemicalsd) (In situ) micro- and nanoscale characterization combining advanced spectroscopic techniques with the state-of-the-art in microscopy.This project describes the potential of atomic layer deposition (ALD) to tune the selectivity of base metal nanoparticles while also stabilizing them. ALD applied to catalysts is an emerging field to which the group of Prof. Dumesic, at the University of Wisconsin-Madison (UWM), is taking a pioneering role. With the continued rise of biomass-derived molecules, the development of more efficient hydrodeoxygenation and hydrogenation methods is paramount. Levoglucosenone (LGE) is an emerging bio-derived building block obtainable in one step from cellulosic biomass. Examples to its potential are the prospected use of dihydrolevoglucosenone (LGO as hydrogenated LGE) as a solvent replacement for toxic N-methyl-2-pyrrolidone and the possibility to convert LGE/LGO into 1,6-hexandiol, 1,2,6-hexantriol and caprolactone by hydrodeoxygenation (DuPont patents). ALD modified catalysts will be applied to the hydrodeoxygenation and hydrogenation of LGE and derivatives. Complementary to the first two years at UWM, the third year in the group of Prof. Weckhuysen, at Utrecht University, will add particular focus to the characterization of thes