RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Discontinuities in CO2 Storage Reservoirs' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The current scientific consensus indicates that it is vital to reach zero carbon dioxide (CO2) emissions by 2050 in order to avoid a large number of negative and unprecedented impacts on our planet due to global warming, such as extreme weather events, significant sea level rise, extinction of species and loss of biodiversity, among many others. It is therefore clear that a series of parallel mitigation actions must be undertaken, among which CO2 sequestration in geological repositories plays a major role.  A worldwide application of this technology can take place only if a long-term storage of CO2 is assured, which, in turn, depends on a deep understanding of the reservoir characteristics. In this context, naturally-occurring or artificial underground mechanical discontinuities (MDs) are ubiquitous features which constitute the primary reasons for possible hazards associated with CO2 injection operations. DISCO2 STORE consortium thoughtfully examines MDs, in order to provide new knowledge and tools towards a riskless CO2 injection practice. This enterprise is tackled by building an interdisciplinary and international network, gathering 12 institutions from EU and TC. It congregates 36 experienced researchers, from academic and non-academic institutions, that share their variety of research expertise by means of international secondments and promote high-level training in a topic of high social impact. In addition, 20 PhD students participate in the project, gaining knowledge and acquiring competences on this environmental hot topic, in an international and stimulating framework. The outputs of this ambitious research proposal permit a deeper understanding of the effects of MDs and contribute towards making CO2 geological sequestration operations a safer and more reacha
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Functional Genomics of the Lysosome'.

assistant: **Concept**

For a long time the lysosome has been viewed as a “static” organelle that performs “routine” work for the cell, mostly pertaining to degradation and recycling of cellular waste. My group has challenged this view and used a systems biology approach to discover that the lysosome is subject to a global transcriptional regulation, is able to adapt to environmental clues, and acts as a signalling hub to regulate cell homeostasis. Furthermore, an emerging role of the lysosome has been identified in many types of diseases, including the common neurodegenerative disorders Parkinson's and Alzheimer’s. These findings have opened entirely new fields of investigation on lysosomal biology, suggesting that there is a lot to be learned on the role of the lysosome in health and disease. The goal of LYSOSOMICS is to use “omics” approaches to study lysosomal function and its regulation in normal and pathological conditions. In this “organellar systems biology project” we plan to perform several types of genetic perturbations in three widely used cell lines and study their effects on lysosomal function using a set of newly developed cellular phenotypic assays. Moreover, we plan to identify lysosomal protein-protein interactions using a novel High Content FRET-based approach. Finally, we will use the CRISPR-Cas9 technology to generate a collection of cellular models for all lysosomal storage diseases, a group of severe inherited diseases often associated with early onset neurodegeneration. State-of-the-art computational approaches will be used to predict gene function and identify disease mechanisms potentially exploitable for therapeutic purposes. The physiological relevance of newly identified pathways will be validated by in vivo studies performed on selected genes by using medaka and m
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Investigations of viscous venting and treatment of releases' to be submitted under Fourth Framework.

assistant: **Abstract**

Polymerization reactors are widely used throughout the industrialized world in the production processes of many common materials such as polystyrene, polyvinylchloride (PVC) and polyacrylates (e.g. plexiglass). A survey carried out in 1990 by the UK Health and Safety Executive showed that, over period up to 1987, an average of five serious industrial incidents due to runaway polymerization reactions occurred every two years. Against this background, and in the framework of reduction of risks to human health and the environment, many of Europe's leading chemical companies have expressed a strong need to improve the modelling capability available for the design of emergency pressure relief systems for such reactors. The present proposal is focussed on this area and is characterised by a problem-solving approach. Many runaway reactions that are of greatest concern are those that involve highly-viscous multiphase fluids (viscosities typically greater than 1000cP). There are considerable uncertainties in specifying the required safety valve and pipe sizes to handle such fluids so that, if activated, the emergency pressure relief systems will be able to discharge reactor contents at a rate that will prevent a dangerous build-up of pressure and temperature in the reactor vessel. However, the basic hindrance to the development of improved modelling techniques is the extremely limited experimental database on the flow of highly-viscous multiphase fluids (reacting and non-reacting) in vessels, safety valves and piping. In view of the variety of polymerization processes, it is necessary for this project to adopt a generic approach, i.e. to perform experiments that allow high-viscosity effects to be studied systematically and, on this basis, to develop generalised physical models f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A web-platform interfaced software for spectroscopic molecular characterization and early diagnosis of Parkinson's disease' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The goal of this proposal is the production of the SEMISOFT software and an associate web platform for spectroscopic molecular characterization and early diagnosis of Parkinson’s disease. SEMISOFT will be designed to decipher complex IR/Raman spectra which are currently hampering development of new clinical protocols and other technological advances. This will be achieved upon implementation of the innovative semiclassically approximate quantum dynamics methods, developed in the parent ERC-CoG SEMICOMPLEX project, which allow for a simplification of complex spectra and unprecedented quantum mechanical accuracy. To further increase the level of accuracy in SEMISOFT simulations, a new machine-learning based force field for biological systems will be developed and incorporated in the software.The SEMISOFT web platform will be accessible to non-expert users from any browser without desktop installation and based on a flexible drop-down menu instructing the user step by step. The user will be able to reproduce IR/Raman spectra and identify molecular species in gas, liquid, or solid state. The web platform will find immediate application in a “freemium” version thanks to an industrial partner laboratory whose goal is to find biomarkers of Parkinson’s disease in human saliva. This pilot test will allow the team to tune the web platform for future commercialization. An analysis of economic, social and market prospects will be performed to define a value proposition and an appropriate business model, by comparing the feasibility and relative impact of licensing, paid access through a user account, and spin-off. The definition of an appropriate intellectual property protection strategy will be also part of the project. SEMISOFT is expected to have a long-term impact too. Raman an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'I-Learning: immersion/imagery enhanced learning'.

assistant: **Objectives**

Sports trainers have shown that mental rehearsal ('motor imagery') can facilitate motor task acquisition. The goal of this project is to build on the results of this work to develop a completely new technique for the teaching of complex motor skills. In the new I-Learning approach the trainer will be replaced by a virtual reality system, designed to create a sense of presence, which evokes motor imagery in the mind of the trainee and therefore facilitates the acquisition of the task. The project includes laboratory research into the relationship between motor imagery and learning; investigation of the use of virtual reality to evoke motor imagery, as well as practical laboratory evaluation of learning effectiveness. This will be based on Virtual Environments developed by the project. The new approach will be tested in two areas with high societal impact: the rehabilitation of neurological patients and the teaching of safe driving. Sports trainers have shown that mental rehearsal ('motor imagery') can facilitate motor task acquisition. The goal of this project is to build on the results of this work to develop a completely new technique for the teaching of complex motor skills. In the new I-Learning approach the trainer will be replaced by a virtual reality system, designed to create a sense of presence, which evokes motor imagery in the mind of the trainee and therefore facilitates the acquisition of the task. The project includes laboratory research into the relationship between motor imagery and learning; investigation of the use of virtual reality to evoke motor imagery, as well as practical laboratory evaluation of learning effectiveness. This will be based on Virtual Environments developed by the project. The new approach will be tested in two areas with high socie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Next-Generation Antibody-Drug Conjugates for safer and more effective cancer therapies' under Horizon 2020.

assistant: **Concept**

Oncolinx has developed a novel molecular platform allowing for non-invasive and highly effective cancer cures. The platform carries a killing drug (Azonafide), linked to an antibody, specifically targeting and destroying only malignant tumour cells. These molecular complexes are called Antibody Drug Conjugates (ADCs) and represent a strong, valid alternative to current chemotherapies. Oncolinx’s innovative linker/payload technology enables the Azonafide platform to perform a sensitive discrimination between healthy and cancer cells, thereby avoiding adverse side-effects of chemotherapy. ADCs enhance the effectiveness of a systemic treatment and have the advantage of targeting only tumour sites within the same therapy. Oncolinx’s drugs are effective against drug resistant cancers, as well as cancer stem cells (CSCs)—cells directly responsible for drug-resistance, metastasis, and relapse. In addition, Oncolinx’s technology activates the immune system against the tumour, which is an integral hallmark of durable responses. Although Oncolinx’s platform is designed to be adopted for drug-resistant breast cancers as first application, the Azonafide payload potency has been validated across all NCI-60 cell lines screening for different tumour types. The NCI-60 Human Tumour Cell Lines Screen also showed that the Azonafide payload, when conjugated with Oncolinx linker technology to specific antibodies, can kill up to 98.2% of cancer cells while remaining non-toxic to cells that do not express the antigen. NCI-60 screening has shown subnanomolar-picomolar potency across cancers  (1x10-9M). While a variety of ADCs compound are currently developed and tested, only two ADCs have been approved so far. However, because Azonafide platform has a unique mechanism of action, Oncolinx can e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Claiming ‘Sexual Minority’: A Transnational Political History, 1921–1981.' (QLAIM) targeting Horizon Europe.

assistant: **Abstract**

Claiming ‘Sexual Minority’: A Transnational Political History, 1921–1981 [QLAIM] challenges the established historiographical premise that the political concept of the ‘sexual minority’ originated in the post-1945 United States. QLAIM instead locates its roots in early 20th-century East-Central Europe (ECE) and traces its transnational dissemination over subsequent decades, offering a new genealogy for modern queer politics. The project hypothesises that this emergence in ECE was no coincidence: it drew on local nationalist imaginaries, particularly the interwar concept of ‘national minorities’, most prominently Germans in Czechoslovakia and Jews in Poland. Defining (homo)sexuality in analogy to ethnicity and nationality set in motion consequences that continue to reverberate today. On one hand, it enabled homosexuals—long pathologised by medicine and criminalised by law—to claim protected status as members of a distinct community. On the other, it allowed nationalists to cast the ‘sexual minority’ as alien within the nation, producing a homophobia framed in nationalist terms and echoing antisemitic and xenophobic tropes. QLAIM combines extensive multilingual archival research (Czech, German, Polish, Slovak, English) with interdisciplinary training at the University of Antwerp, deploying digital tools (corpus analysis, network visualisation, digital history) to map and disseminate the transnational circulation of ‘sexual minority’ as a cultural and political concept. Recovering this history matters today: across Europe, minorities face persistent hostility, increasingly articulated in nationalist language. Psychologists call this chronic strain minority stress, theorised in 1981 with reference to sexual minorities, yet reflecting wider mechanisms of exclusion. QLAIM’s i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Researcher's Night: meeting science and your next door scientist', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

A diverse team of experts in scientific research and science communication from leading Research Institutes and Educational Organizations located in the Athens Metropolitan area is formed to organize the Researcher's Night activities for the years 2014 and 2015. By adopting the concept “Science invites People”, we propose a large scale REN, in 2014, at NCSR Demokritos, the largest Science Research campus in Attica, and a similar event in 2015, at IME a multiplex where science meets entertainment and exploration, organized by the National Observatory of Athens . Based on past experience, we plan activities for an expected attendance of several thousand visitors. Our proposal involves activities from several scientific domains exemplifying in many cases the benefits of Interdisciplinarity. The activities will include the organization of pre-events, as part of the awareness campaign, as well as parallel events at three regions throughout Greece including Rodos, Corinth and Pylos, where parτicipating Institutions have satellite installations, so as to maximize impact and reach. Researcher's Night 2015 events will be linked with another major Researcher's Night event planned to take place in Rome, through the support of the local establishment of the European Space Agency (ESA). The purpose of the project is to convey to the general public the ideas that Research is a necessary ingredient for progress, the Researchers are an integral part of the community and their profession is both fun, challenging, interesting and worth pursuing. The presentation of the work of the scientists to the Greek public will showcase the need of scientific and technological breakthroughs leading to inventions and opportunities that benefit society in many ways..


**Keywords:** science, career, a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'DIAGNOSTIC AND EVALUATION TOOLS FOR NATURAL LANGUAGE APPLICATIONS' (DIET) under Fourth Framework.

assistant: **Objectives**

DIET addresses requirements for the assessment of natural language processing (NLP) components in adequacy evaluation and quality assurance. Effective and efficient assessment is often hampered by the lack of suitable test material and technology. DIET will develop methods and tools for the glass box evaluation of NLP components, building on the results of previous projects covering different aspects of assessment and evaluation. It will extend and develop test suites with annotated test items for grammar, morphology and discourse, for English, French and German. DIET will provide user support in database technology, test suite construction tools and graphical interfaces. The project results will be used by the industrial partners for in-house and external quality assurance and evaluation. They will also be made available in the public domain through appropriate channels.Effective and efficient assessment of Natural Language (NL) processing components is often severely hampered by the lack of suitable test material and technology, which are expensive to develop both in time and cost. A large variety of evaluation tools has been produced but these are mainly specialised toward testing specific pieces of software. Developing reusable components is normally outside the interests of individual companies. However, the emerging language technology industry needs these tools, both for industrial developers of NL products, to monitor quality, and for end users so that they can evaluate the suitability of different products. DiET will address this by developing methods and tools for 'glass box' evaluation of NL components. These tools will be reusable and customisable, together with reference data organised in test suites annotated with items for grammar, morphology and discours
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'ATMINistrating ATM signalling: exploring the significance of ATM regulation by ATMIN' (ATMINDDR) under Seventh Framework.

assistant: **Objectives**

ATM is the protein kinase that is mutated in the hereditary autosomal recessive disease ataxia telangiectasia (A-T). A-T patients display immune deficiencies, cancer predisposition and radiosensitivity. The molecular role of ATM is to respond to DNA damage by phosphorylating its substrates, thereby promoting repair of damage or arresting the cell cycle. Following the induction of double-strand breaks (DSBs), the NBS1 protein is required for activation of ATM. But ATM can also be activated in the absence of DNA damage. Treatment of cultured cells with hypotonic stress leads to the activation of ATM, presumably due to changes in chromatin structure. We have recently described a second ATM cofactor, ATMIN (ATM INteractor). ATMIN is dispensable for DSBs-induced ATM signalling, but ATM activation following hypotonic stress is mediated by ATMIN. While the biological role of ATM activation by DSBs and NBS1 is well established, the significance, if any, of ATM activation by ATMIN and changes in chromatin was up to now completely enigmatic.ATM is required for class switch recombination (CSR) and the suppression of translocations in B cells. In order to determine whether ATMIN is required for any of the physiological functions of ATM, we generated a conditional knock-out mouse model for ATMIN. ATM signaling was dramatically reduced following osmotic stress in ATMIN-mutant B cells. ATMIN deficiency led to impaired CSR, and consequently ATMIN-mutant mice developed B cell lymphomas. Thus ablation of ATMIN resulted in a severe defect in ATM function. Our data strongly argue for the existence of a second NBS1-independent mode of ATM activation that is physiologically relevant. While a large amount of scientific effort has gone into characterising ATM signaling triggered by DSBs, essen