RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Simple and cost-effective cancer diagnosis in liquid biopsy through native tRNA sequencing' (2021-2027) under Horizon Europe.

assistant: **Objectives**

Transfer RNAs (tRNAs) are abundant, heavily-modified small non-coding RNAs that play a pivotal role in decoding genetic information, determining which transcripts are highly and poorly translated at a given moment. Dysregulation of tRNA abundances and tRNA modifications is a well-known feature in cancer cells, leading to enhanced translation of specific oncogenic proteins. Despite the well-established association between tRNA dysregulation and cancer progression and malignancy, tRNA abundances and their modifications are still not being used as diagnostic or prognostic markers for cancer detection or progression, mainly due to the lack of a simple, unbiased and cost-effective method to quantify tRNA abundances and their modifications. Our laboratory has recently established Nano-tRNAseq, a pioneering method that can accurately quantify both tRNA abundances and tRNA modifications using native tRNA nanopore sequencing, for a fraction of the cost of next-generation sequencing-based approaches. By employing a proprietary Nano-tRNAseq nanopore library preparation protocol coupled with deep learning algorithms that will rapidly classify the nanopore current signals, here we aim to establish a method that exploits tRNAs as novel biomarkers through the use of third generation sequencing technologies. We have initial evidence of how our approach can separate cancer from non-cancer samples and possibly be used to identify the tissue of origin. In this project, we will fully validate our technological platform for the differential analysis of low-input RNA amounts in liquid biopsy samples. We will initially apply our method in the cancer arena, expandable to many other indications, following the advice of key stakeholders contacted so far, with the goal of laying the basis for the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Identification of new molecular and genetic basis of ammonium use efficiency in plants' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Sustainable agriculture means to maintain equilibrium between obtaining a product at the best possible yield and with the best possible quality at the same time that the minimum environmental impact is provoked. Among the major challenges that the European Commission Horizon 2020 describes to be faced by researchers in the near future for building a better society, resources efficiency and sustainable agriculture are two of them.Nitrate (NO3−) and ammonium (NH4+) are the main forms of nitrogen (N) available for plants. There is serious concern regarding NO3− loss in the field, giving rise to soil and water pollution and to global warming through emissions of nitrous oxide. In this framework, the use of ammonium-based fertilizers is a great opportunity to reduce environmental pollution effects of nitrate-based manures. The potential of NH4+ as N source for agriculture has been reconsidered alongside the search to improve N use efficiency by the Intergovernmental Panel on Climate Change (IPCC). However, plants have traditionally been bred under nitric or combined nitrogen nutrition provoking a negative selection pressure towards NH4+ assimilation. Indeed, NH4+ is toxic to animals, plants, and fungi when present in excess amounts.In this project, a multidisciplinary approach will be engaged to identify new molecular and genetic basis of ammonium use efficiency in plants. With this aim, 384 natural accessions of Arabidopsis will be phenotyped and a Genome Wide Association analysis will be launched to identify genetic determinants of ammonium use efficiency in Arabidopsis. In parallel, Arabidopsis genetic reprogramming during ammonium nutrition will be assayed by RNAseq. The more interesting candidate genes will be functionally validated. Importantly, the knowledge and resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'KilonovaRank: gravitational wave counterparts and exotic transients with next-generation surveys'.

assistant: **Objectives**

Time-domain astronomy will soon be transformed by powerful instrumentation: the Large Synoptic Survey Telescope (LSST) and upgraded gravitational wave detectors. We will finally be able to build large samples of rare and multi-messenger transients, allowing new scientific breakthroughs. But to do so, we must overcome the substantial difficulty of identifying the important events among an expected sea of contaminants. I will solve this problem by developing novel image classification techniques before LSST begins, and then use this with LSST data to answer some of the most pressing questions about stellar evolution, nucleosynthesis, and high energy physics. I will discover hundreds of superluminous supernovae (SLSNe), key to unknown physics in massive stars, and tidal disruption events (TDEs) of stars around supermassive black holes, probing black hole accretion in usually inaccessible regimes. By folding in the sky maps from GW detections of neutron star mergers, I will rapidly find kilonova counterparts in LSST follow-up searches. With 10-100 kilonovae (compared to 1 well-studied event now), we will understand the nucleosynthesis of all heavy (r-process) elements, determine the equation of state for nuclear matter, and pin down what these mergers leave behind. Moreover, I will determine the progenitor stars and power source of SLSNe, and the emission mechanisms in TDEs and relation to black hole mass, using even larger samples of those events. We may even find whole new transient classes. This project could not be more timely as the upgrades in GW detectors, the start of LSST, and the brief era of JWST will overlap in just a few years (and within the time of an ERC-funded project). Everything is in place for success, from guaranteed data access and follow-up resources,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Linking tannins, biological activities and genetic maps in a unique willow germplasm collection'.

assistant: **Concept**

Recent research in livestock farming has focussed on condensed tannins (CT) in feeds, because of their potential benefits for ruminant nutrition and health and for improving the quality of animal products. In the past, all tannins were mistakenly described as ‘anti-nutritional factors’. More recent studies have, however, demonstrated that CT can generate useful benefits for animal welfare and production. Unfortunately, most studies involving CT and animal feeds have been carried out ignoring the great structural diversity that exists among plants and have led to contradictory findings. Plants produce a wide range of different tannins, and tannin composition can differ enormously between plant species, varieties and plant parts. Therefore, investigations into the beneficial or detrimental effects of tannins need to consider all aspects of their structural variation in order to allow conclusions that are scientifically sound. The scientific community urgently requires sound data in order to select plants with desirable tannin properties and to generate sustainable, high quality animal products. This research project seeks (1) to analyse tannin contents and structures in a model plant species (Salix spp.) within a unique and genetically well-characterised germplasm collection; (2) to investigate relationships between tannin structure and their biological effects for ruminant production and health; (3) to identify the genetic traits that control tannin structural features and their bioactivity. If successful, this project will generate a scientific breakthrough in terms of tannin traits that should be evaluated and selected in future research programmes in order to improve the sustainability and quality of ruminant production systems. Results from this research will contrib
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Pathogenesis and treatment of chronic airway disease: novel animal models for studies on modifier genes, lung repair mechanisms and novel therapeutic strategies' under Sixth Framework.

assistant: **Concept**

Chronic airway diseases like asthma, chronic bronchitis and cystic fibrosis belong to the most frequent chronic diseases in Europe. Progress in the understanding of the pathophysiology and development of effective treatments for these diseases has been ham pered by the lack of good animal models, i.e. even knock-out" mice for the monogenic disease cystic fibrosis lacked a lung disease phenotype. We have recently developed a novel transgenic mouse model with airway-specific overexpression of epithelial sodiu m channels (ENaC) and demonstrated that a dysbalance of airway ion transport causes a severe spontaneous lung disease that shares common features with human chronic airway diseases, including mucus obstruction, goblet cell metaplasia and inflammation (Mall M et al, Nat. Med. 2004). The overall goal of this project is to exploit and further develop this animal model for studies on the pathogenesis and the development of novel treatments for chronic airway diseases. We will test the therapeutic in vivo effect s of ion channel modulators, and novel inhibitors of inflammation and mucus hypersecretion. Furthermore, we will identify novel genes that modify disease severity in bENaC overexpressing mice by a microarray approach. Finally, we will establish a novel mou se model with an inducible chronic bronchitis phenotype to circumvent early pulmonary mortality associated with constitutive bENaC overexpression. We will use this regulated model for studies on the role of chronic exposure to allergens and pathogens, and endogenous lung repair mechanisms acting once the bENaC transgene is switched off. The success of this project will build upon the high level of expertise of the team leader and host in the proposed tasks. It will result in the establishment of an interdis cipl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Conservation Genetic Resources for Effective Species Survival' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Genetic biodiversity is recognised by the Convention on Biological Diversity and the EC Biodiversity Strategy as one of three essential elements of living diversity, yet it is poorly represented at the policy level, compared to the two other components, species and ecosystems. The CONGRESS consortium aims to rectify this situation by delivering dissemination tools which policy makers and conservation managers can conveniently use to incorporate genetic biodiversity into their policy framework. The six work packages of this project fall into two components. The first component comprises WPs 1 – 5 which will provide a one-stop, community-enabled web portal, including the following components. WP1 concerns web portal design and construction. WP2 will provide databases on academics and professional end-users, publications and genetic data for key European species of conservation concern. WP3 will provide a simulation tool for biodiversity managers to assess the power of genetic data to reveal processes which may result in genetic erosion. WP4 will provide a decision matrix module to allow end-users to establish optimal policy and management options given the genetic data which have been produced. WP5 will provide a knowledge pack and information leaflets, translated into the main European languages, which can be assembled into a manual. The second component is WP6, which comprises a series of dissemination and exchange workshops carried out across the European Union, including a transborder workshop and hands-on demonstration meeting in Eastern Europe. CONGRESS will integrate and enhance these work packages by using the workshops as forums to discuss the contents of the portal and will be guided by an end-user advisory group, who will oversee the development of these tools
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Novel Soliton Synchronization and Interactions in Coupled Kerr Combs' (NSINC).

assistant: **Concept**

The ""N'Sinc"" project aims to study novel soliton synchronization and interactions in a coupled Kerr soliton cavity network and to demonstrate dual-comb technologies enabled by these novel interactions. Temporal dissipative Kerr solitons (DKS) in micro-resonators have recently emerged as a powerful platform for both fundamental nonlinear science and ground-breaking technologies. While nearly all efforts thus far have focused on single isolated Kerr cavities, coupled Kerr cavity systems offer compelling new physics and technologies including that of passively phase-locked dual-comb spectroscopy, ranging and ultrastable RF sources. The applicant recently developed a numerical model which predicts novel soliton interactions in such a system, among them soliton synchronization and soliton “hopping” wherein a soliton abruptly hops from one cavity into an adjacent cavity. This proposal will fabricate a coupled two-cavity network and investigate its capability for the predicted effects and for other novel effects such as non-identical FSR locking. This will be pursued using both Magnesium Flouride crystalline resonators and Silicon Nitride microresonators, which are well-established technologies in the host group. This project comes at an exciting time for the Kerr soliton combs field since single Kerr cavities have become well understood and new tools have been developed which can enable the precise fabrication and control of two-cavity systems. Many of these tools have been developed in the host group. It is one of the top groups in the world and the only group in Europe capable of such a project and has been responsible for establishing the Kerr soliton combs field in Europe. Whereas many U.S. groups are pursuing similar goals, the applicant has made the first numerical pr
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'E-FREE (Smart Solutions): Towards a more ECO, HEALTHY and SAFE environment in every single lighting scenario.' (E-FREE).

assistant: **Concept**

EKIONA is a company specialized in personalized solar lighting solutions. It develops, manufactures and commercializes Solar street lights located mainly in urban, residential, industrial, sports and recreational venues. EKIONA offers top lighting solutions for bicycle paths, pedestrian malls, country sides, sports fields, parks, rural paths, housing developments, roundabouts, roads, parking lots and similar applications.Since its foundation in 2010, several Solar Street Light projects have been carried out between EKIONA and some of the regions of Spain, including San Sebastian, Bilbao, Logroño, Madrid, Barcelona and Canary Islands. Currently, EKIONA is having traction from customers to include other packs in its Solar Street Lights. Spanish customers and also international customers, mainly customers from the Middle East (Qatar and UAE), are interested in integral solutions.Service Packs that are being requested are related to the improvement of the quality of life for citizen. Health care, security, sustainability and economy are being the figures that are considered in these service packs. The service packs are aimed to be sensor based systems that collect data from the environment, record it, analyse it and create results when possible. It is envisaged Solar Street Lights and add-on Systems on-line connected to Smart Cities and their frameworks.EKIONA is planning to perform pilot projects to check the logic and requirements of these systems. Pilot projects have been agreed with local governments from San Sebastian, Vitoria, Logroño and Madrid regions. The main objective in Phase I is to analyse possible ways to monetize those on-top services of the B2B and B2G business models that EKIONA has with Solar Street Lights and its potential markets.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'An intelligent support environment to improve the quality of decision processes in health communities' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

The goal of CARE-PATHS is to set up an intelligent operational environment for making Clinical Governance effective, to support Health Professionals, Clinicians and Care Operators, in continually improving the quality of their services and safeguarding high standards of care. The approach adopted by CARE-PATHS is to exploit emerging technologies in knowledge management and semantic web for enabling the methodology of Clinical Pathways" to function, to be effective and to succeed.The output of the project will be a set of intelligent tools for supporting Health Professionals in authoring conceptual clinical pathways for selected group of pathologies in specific contexts, putting them in practice in the everyday treatment of individual patients, monitoring and managing the variances. CARE-PATHS will be tested in different health scenarios, in Spain and in Italy.From the technological point of view, the objectives are concentrated primarily, in the following technologies of the knowledge management and distribution domains:-Middle-ware enriching the semantic web for clinical governance-Access to databases from the medical, nursing, and health services literature fully referenced and individually graded, based upon clearly defined research methodology and that address aspects of care thought to be the key drivers of quality and cost in health services delivery.-Referential tools that focuses on studies from the peer-reviewed medical literature pertaining to clinical and operational efficiency, utilization of resources, cost of care, and processes of care and other factors that influence complications, length of stay, and readmissions.-Semantic based agents to "broker" between information sources on clinical guidelines, evidence based medicine and the actual ambient (technol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Moduli of flat connections, planar networks and associators""' (MODFLAT) targeting Seventh Framework.

assistant: **Abstract**

The project lies at the crossroads between three different topics in Mathematics: moduli spaces of flat connections on surfaces in Differential Geometry and Topology, the Kashiwara-Vergne problem and Drinfeld associators in Lie theory, and combinatorics of planar networks in the theory of Total Positivity.The time is ripe to establish deep connections between these three theories. The main factors are the recent progress in the Kashiwara-Vergne theory (including the proof of the Kashiwara-Vergne conjecture by Alekseev-Meinrenken), the discovery of a link between the Horn problem on eigenvalues of sums of Hermitian matrices and planar network combinatorics, and  intimate links with the Topological Quantum Field Theory shared by the three topics.The scientific objectives of the project include answering the following questions:1) To find a universal non-commutative volume formula for moduli of flat connections which would contain the Witten’s volume formula, the Verlinde formula, and the Moore-Nekrasov-Shatashvili formula as particular cases.2) To show that all solutions of the Kashiwara-Vergne problem come from Drinfeld associators. If the answer is indeed positive, it will have applications to the study of the Gothendieck-Teichmüller Lie algebra grt.3) To find a Gelfand-Zeiltin type integrable system for the symplectic group Sp(2n). This question is open since 1983.To achieve these goals, one needs to use a multitude of techniques. Here we single out the ones developed by the author:-Quasi-symplectic and quasi-Poisson Geometry and the theory of group valued moment maps.-The linearization method for Poisson-Lie groups relating the additive problem z=x+y and the multiplicative problem Z=XY.-Free Lie algebra approach to the Kashiwara-Vergne theory, including the non-commut