RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'COMPLEMENT AND ATHEROSCLEROSIS: MOLECULAR MECHANISM OF C1 ACTIVATION BY ENZYMATICALLY MODIFIED LOW-DENSITY LIPOPROTEINS' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Atherosclerosis is considered to be a chronic inflammatory process. Arterial inflammation that precedes plaque development is caused by accumulation of LDL (low density lipoproteins) in the extracellular matrix of the vessels. These LDL particles are modified by a number of processes, including enzymatic degradation, aggregation and oxidation. Complement is also emerging as an important factor in this process: complement activation and formation of the terminal C5b-9 membrane attack complex were shown to occur in atherosclerotic lesions. Recently we have studied the ability of enzymatically modified LDL (E-LDL) to activate C1, the complex that triggers the classical pathway of complement. E-LDL is recognized by the C1q subunit of C1 and triggers direct C1 activation, suggesting that complement activation by E-LDL may play a crucial role in the pathogenesis of atherosclerosis. The objective of this proposal is to characterize the mechanisms involved in the recognition of E-LDL by C1q. We aim at (i) identifying the molecules recognized by C1q; (ii) characterizing the molecular mechanisms involved in this recognition; and (iii) analyzing the mechanisms underlying E-LDL-mediated C1 activation. The project is based on approaches at the molecular and structural levels, and will involve protein biochemistry methods, X-ray crystallography, surface plasmon resonance spectroscopy and functional studies. From a fundamental standpoint, the immediate benefit of this work will be to improve our knowledge of the mechanisms that allow C1q to act as a “sensor” of altered self structures. The biomedical applications of our results could have a considerable impact in the development of new therapeutic strategies against atherosclerosis, because the molecular mapping of the interaction bet
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Understanding soil microbially mediated mechanisms that influence plant species co-existence in natural communities'.

assistant: **Innovation**

Conservation of biodiversity depends on understanding the mechanisms that determine species richness and their relative abundances. The basic scientific question on which this IRG proposal is based is why are some plant species more abundant than others? Different theories have been proposed to explain the mechanisms of plant coexistence. However, not only do they not provide a satisfactory answer, but also, they largely ignore an increasingly recognized important component; the roles of the soil biota. A large part of a plant is its root system which grows in soil, a matrix that, due to its characteristics, serves as habitat for a huge diversity of organisms, many of which interacting with plants. This proposal focuses on the outcomes of these interactions, particularly on identifying the role of equilibriums between beneficial and damaging interactions and to which extent the role of the former ones is to keep the latter ones at bay. It is predicted that the outcomes of these interactions vary depending on plant traits, ultimately determining a species relative abundance. The IRG will focus on a target natural grassland community and on the arbuscular mycorrhizal (AM) symbiosis, which is widespread among plants. A combination of molecular and classical techniques will be used to investigate whether abundant plants receive greater pathogen protection from the AM symbiosis than rare plants. The IRG will be conducted in collaboration with experts from the Univ. of Potsdam in the area of theoretical plant ecology, which is complementary to the applicant’s expertise. It is expected that the results will increase our understanding of the role of soil-plant-microbe interactions in ecology and their potential to be managed to prevent the loss of plant species. Furthermore, by
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'East-West European comparison of chronic disease risk factors, related health behaviours and effects of innovative antismoking interventions, with special reference to Russian Karelia' in the context of a Fourth Framework call.

assistant: **Objectives**

-To assess east-west differences in main cardiovascular disease risk factors.-To assess the health behavior pattern in participating countries.-To compare the feasibility and the effectiveness of smoking cessation contest as a health promotion method in different cultural settings.-To evaluate effects of an innovative antismoking intervention in Russian Karelia.During the last decades the life-expectancy in Western European countries has increased relatively steadily, while countries of Central and Eastern Europe have experienced an alarming deterioration in life-expectancy. Available information shows that the east-west gap is explained especially by CVD, cancer and violent deaths. Causality of major risk factors have been identified by intensive medical research. We still lack good and comparable information on risk factors in Western and Eastern Europe. Information is needed to be able to assess whether the large gap can be explained by similar differences in risk factors and lifestyles. The project carried out in six Europe well representative countries of EU and C&EEC (Finland, Germany, Spain, Hungary, Poland and Russia) will be divided in four main parts: risk factor survey, health behavior survey, evaluation of the Quit and Win 1996 campaign and evaluation of an innovative intervention in Russian Karelia. The aim of the risk factor survey is to analyze CVD risk factor data from very comparable surveys of representative population samples of 25 to 64 year old people. The differences between the countries and particularly the east-west differences will be assessed. The health behavior survey will be done by standardized questionnaire before the smoking cessation contest in the participating areas. Particular emphasis will be put on smoking related health behavior.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Pneumatic manipulator of stock ining for plastic boots controlles by fuzzy logic for injection footwear industry' (1994-1998).

assistant: **Concept**

The footwear technology of plastic boot consists of the injection of the upper over a sock lining and than the moulding of the sole onto the upper by a injection machine. A common problem of the bootmakers is the continuous potential danger of serious accidents that can occur to the workman that operates near the injection machine for lasting the sock lining on the aluminium last. This project is aimed to develop a pneumatic manipulator to be enslaved to the rotary machine which is able to last, stitch and cut a sock lining on the last simulating the movements of the hands. To obtain a smooth and adaptive adjusting of the sock lining on the last, the actuators of the manipulator will be driven by fuzzy logic control system.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Early pathogenetic markers of slow neurodegenerative diseases' (1998-2002).

assistant: **Innovation**

In response to Para 6.1 of the Sol Work Program, it is proposed to show that in various slowneurodegenerative diseases protein misfiling causes early changes in intracellular function, which serves important pathogenesis markers of disease onset and progression. Focus will be on Parkinson's, Huntington's and prison diseases, but the project will also have impact on other neurodegenerativedisoders of aging. In these disorders, there is currently an urgent need for methods that can identify early cell pathology and monitor treatment effects at the cellular level. Using a multidisciplinary approach, the objectives are to reveal, sequentially, in tissue culture, transgenic animals and in cells derived from patients, the early stages of mutant protein aggregate formation and its consequences. Emphasis will be on parameters of neuronal dysfunction, but changes in blood will also be demonstrated as early indicators of neuronal disease lymphocytes in mice and men exhibitingneurodegeneration. Therapeutic strategies to intervene in protein misfiling will be tested, with the aim to transfer this knowledge to clinical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Leveraging Sacrifice to Strengthen Relationships: The Importance of Couples’ Sacrifice Communication' (SAYcrifice), addressing dissemination and exploitation.

assistant: **Impact**

Romantic relationships are essential for health and well-being. In fact, a poor-quality relationship is a more powerful predictor of increased mortality than smoking. Yet, divorce rates have more than doubled among the 27 EU countries in the last five decades. One reason why relationships are hard to maintain is because couples face difficulties navigating challenging interactions, such as when one partner sacrifices their preferences for the other. Sacrifice occurs regularly and can fuel resentment, thus putting relationships at risk. Yet, sacrifice also may convey that the sacrificer cares about the recipient, and thus has the potential to strengthen relationships. Given the profound impact of relationships on health and well-being, it is crucial to identify how couples can reduce the costs and reap the benefits of sacrifice to maintain satisfying relationships.Existing research examining the impact of sacrifice has focused on individuals internal feelings and motivations. Prior work, however, overlooks how individuals express their feelings and thoughts about the sacrifice, and neglects the dyadic interaction between the sacrificer and recipient. SAYcrifice aims to address these critical gaps by examining (1) how both partners communicate about sacrifice and (2) how sacrifice communication styles shape personal and relationship outcomes. SAYcrifice will integrate across different fields (relationship science, communication, social cognition) and combine state-of-the-art methods (dyadic, observational, diary, and longitudinal methods; implicit and explicit measures) to provide the first comprehensive investigation of couples sacrifice communication in close relationships. The findings will reveal effective ways for couples to communicate about sacrifice, which can be
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'TACKLING ANTIBIOTIC OVER-PRESCRIPTION', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Within the ever changing and ever innovative field of healthcare diagnostics, ShanX Medtech and Dr. Sophia Eriola Shanko are dedicated to bringing personalised diagnostic testing to the point-of-care, ensuring the timely and appropriate administration of antibiotics to patients.Worldwide over 400 million people visit their doctor with a Urinary Tract Infection (UTI) every year. With the majority of UTIs stemming from a bacterial infection, the treatment thereof is straightforward: an antibiotic prescription. However, for physicians determining the correct antibiotic treatment for each patient remains problematic. Furthermore, the global increase in antibiotic resistance rates reinforces the need to improve antibiotic prescription protocols. ShanX is developing a diagnostic tool that can be used at the doctor's premises and it allows the physician to test a series of antibiotics prior to administration, thereby ensuring the subsequent treatment efficacy. The results provided are fast, accurate, and tailored to each individual patient.ShanX Medtech is revolutionizing the antibiotic treatment workflow by enabling fast, evidence-based  and personalized antibiotic administration. Sophia is proudly building a world where women, like herself, are defining and designing a better future for patient care. She hopes that her positivity and charisma serve as an inspiration to others, and that – while leading by example – true passion paired with determination and grit, can empower women to meet their potential and pursue entrepreneurship.


**Keywords:** point of care testing, femtech, medtech, in vitrod iagnostics, female entrepreneurship
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ABYSS - Assessment of bacterial life and matter cycling in deep-sea surface sediments' (ABYSS).

assistant: **Innovation**

The deep-sea floor hosts a distinct microbial biome covering 67% of the Earth’s surface, characterized by cold temperatures, permanent darkness, high pressure and food limitation. The surface sediments are dominated by bacteria, with on average a billion cells per ml. Benthic bacteria are highly relevant to the Earth’s element cycles as they remineralize most of the organic matter sinking from the productive surface ocean, and return nutrients, thereby promoting ocean primary production. What passes the bacterial filter is a relevant sink for carbon on geological time scales, influencing global oxygen and carbon budgets, and fueling the deep subsurface biosphere. Despite the relevance of deep-sea sediment bacteria to climate, geochemical cycles and ecology of the seafloor, their genetic and functional diversity, niche differentiation and biological interactions remain unknown. Our preliminary work in a global survey of deep-sea sediments enables us now to target specific genes for the quantification of abyssal bacteria. We can trace isotope-labeled elements into communities and single cells, and analyze the molecular alteration of organic matter during microbial degradation, all in context with environmental dynamics recorded at the only long-term deep-sea ecosystem observatory in the Arctic that we maintain. I propose to bridge biogeochemistry, ecology, microbiology and marine biology to develop a systematic understanding of abyssal sediment bacterial community distribution, diversity, function and interactions, by combining in situ flux studies and different visualization techniques with a wide range of molecular tools. Substantial progress is expected in understanding I) identity and function of the dominant types of indigenous benthic bacteria, II) dynamics in bacte
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Enhancement and Indication of food quality by combinations of oxygen scavenger and quality indicator systems for polymer packagings' under Fifth Framework.

assistant: **Concept**

The quality and shelf life of foods is in the most cases reduced by oxygen influence. A wide range of food shows oxidative damage to flavour and colour. The main objectives of the project are the development of combined systems -for indication of food quality and packaging integrity, and at the same time, -for enhancement of product quality and shelf life via oxygen scavenging (indicator-scavenger-systems"). These systems are to be integrated into packaging film materials. The benefits of such an innovative packaging system are:-to reduce the internal oxygen level as low as possible just directly after packing of the product,-to increase the shelf life and the nutritional and sensory quality of food,-to allow for verification of proper functionality of the oxygen scavenger and of product quality and for detection of damages or tampering, throughout the whole logistic chain up to the point of consumption."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Magnetic ENERGY conversion for waste HEAT' to be submitted under Horizon Europe.

assistant: **Abstract**

The production and use of energy account for more than 75% of the EU’s greenhouse gas emissions. Decarbonising the EU’s energy system is therefore critical to reach our 2030 climate objectives and the EU’s long-term strategy of achieving carbon neutrality by 2050. Obviously solar and wind power will play an important role in any future energy scenario, but such intermittent sources present significant challenges in energy transport and storage. At the same time, a vast amount of low-grade heat is generated, e.g. in datacentres, food, pulp and paper industries, and is available 24/7. Even converting only a small percentage of this heat into electricity is significant due to the sheer amount of heat wasted just above ambient temperature. However, efficient technologies to convert this low-grade heat in an economically sound way are lacking Within this project, we will develop thermomagnetic harvesting from current TRL 3/4 proofs of principle to an efficient and cost competitive TRL 6/7 technology. Our interdisciplinary consortium of 9 academic institutes and 4 industrial partners address all major challenges for this emerging technology, which requires innovative designs of more efficient thermomagnetic generators, that are intimately connected with tailored thermomagnetic materials. Our team consists of engineers, who invented thermomagnetic systems at various sizes and power ranges, materials scientists with ample experience in advanced magnetic materials, bulk or film preparation and characterization, and physicists, who cover modelling from the ab initio scale, via micromagnetism at the mesoscale, up to the macroscopic device scale. This rich multidisciplinary environment will allow training of 10 young professionals by cross-fertilization with fresh ideas. They will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'H2O Health Outcomes Observatory' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Patients' outcomes and experience of health care can be improved through the systematic capture and use of information from their perspective. We are currently not using all the information we could gain from Patients' outcomes and experience of health care can be improved through the systematic capture and use of information from their perspective. We are currently not using all the information we could gain from Patient-Reported Outcomes (PROs) to accurately measure value from the patient perspective. This is due to the lack of standardisation, interoperability and implementation of PRO measurement schemes. We urgently need a European scale network of outcomes data collection, analysis and evidence sharing to inform clinical practice and healthcare decisions. To tackle these issues, this public-private consortium brings together scientists, clinicians and professionals to design and set up independent, patient-centred, Health Outcomes Observatories (H2Os).  With input from patients, providers and health care decision makers (health ministries, health insurers, regional health authorities, public health agencies, medicines regulators, health technology assessment agencies), these Observatories will collect data and provide information not only for individual clinical care, but also for evaluation of new technologies and for healthcare decision making. We will establish ethically and legally sound national, or regional, H2Os and run these initially in four countries for three diseases.  Based on a hybrid model of federated and centralised data collection, management and analysis, these Observatories will operate under a governance model that will guarantee that data are protected under jurisdictional data protection law. H2Os will be connected to a pan-European umbrella