RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'B cell receptor engagement and signalling in chronic lymphocytic leukemia: identify the structural and functional requirements for disease development and progression.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

B-cell chronic lymphocytic leukemia (CLL), the most prevalent leukemia among adult Caucasians, is a disease characterized by the clonal expansion of B lymphocytes expressing CD5. The B-cell receptor (BCR) plays a critical role in CLL development and progression as indicated by the efficacy of drugs blocking BCR signaling. However, the mechanism(s) underneath BCR responsiveness are not well-defined and CLL remains incurable. In the classical view, an interaction between BCR and extrinsic antigen is responsible for such signalling. The discovery that CLL BCRs can self-associate and signal in the absence of extrinsic antigens (intrinsic binding) highlighted a novel mechanism for BCR engagement and signalling.  Growing amount of evidences suggest that both extrinsic and intrinsic engagement are required for leukemia development and progression. Herein, we aim to better define the selectiveness of the two BCR engagement mechanisms and their association with specific biological and clinical characteristics. To better define such elusive associations, machine learning algorithms will be developed and used to define the specific links among the biological data. Specifically, we will i) assess BCR engagement features associated with CLL clinical aggressiveness and responsiveness to stimuli; ii) identify normal B cells expressing CLL-like BCRs and evaluate their engagement features and similarity with CLL B cells; iii) identify genes and genetic pathways distinctly associated with either mechanism of BCR engagement and/or CLL aggressiveness.The successful outcome of this proposal would generate biologically and clinically relevant information for prevention, prognosis and therapy of CLL.


**Keywords:** Chronic lymphocytic leukemia, B cell receptor, Immunoglobulin, Signalling
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'High-Performance active Smart-Card with inductive charging' under Fifth Framework.

assistant: **Concept**

A rechargeable high performance smart-card battery has to be developed.The smart-card battery can be recharged inductively.Both, battery and Smart-Card will be one unit during the production process.The smart-card battery is integral part of the electrical circuit within the electronics of the card.Test of a fully integrated smart-card battery.Work description:A compound material for smart cards with battery has to be developed by coupling techniques such as milling, gluing, drilling and coating. This will form a prefabricated part, which combines the battery casing and the electric circuit in a single part.Furthermore, a rechargeable battery system has to be adopted to the demands of the smart card including that all specifications as well as the security aspects of the card with respect to the intended operation will be considered.A special combining process such as the riveting-technology has to be modified in order to ensure the sealing of the smart card with smart card battery and electronics.The rechargeable smart card has to be tested inductively.The feasibility of the project will be demonstrated with simplified test samples.Milestones:Commitment of measures concerning the geometry of the card, materials selection and combination, test of several techniques to combine, development of partial process steps, specification of machinery, test of partial process steps, test of developed compound material parts as battery casing, text of inductive recharge ability.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Stories of Survival: Recovering the Connected Histories of Eastern Christianity in the Early Modern World'.

assistant: **Concept**

From Lebanese immigrants in Argentina to Iraqi refugees in Sweden, Eastern Christians can be found today scattered across the entire world.  Too often, however, this global migration has been seen purely as a modern development, one arising from contemporary political and confessional events in the Middle East, while in fact this phenomenon had its roots in the early modern period.  From the sixteenth century onwards, Christians from the Ottoman Empire set out for distant worlds and foreign lands, travelling as far as Europe, India, Russia, and even the Americas and leaving traces of themselves across countless European and Middle Eastern archives, chanceries, and libraries.  This transnational, ground-breaking project will gather all of these disparate sources into a single analytical frame to uncover, for the first time, the global and connected histories of Eastern Christianity in the early modern world.  Through the work of a team of researchers under the close supervision of the PI, the project will reconstitute and analyse a ‘lost archive’ of literary, documentary, and printed sources in three continents, ten languages, and dozens of archives.  Under the expert leadership of the PI, the project will include a robust strategy for dissemination, which will successfully bridge the fields of Middle Eastern, European, and global history.  In doing so, this project will respond directly to one of the most pressing conceptual challenges facing global history today, that is, how to link the study of the micro-scale level of everyday life to the macro-narratives emphasised by global historians.  Underlying this project, therefore, is a major intervention that seeks to advance a rigorous form of global history, and one which preserves philology and source criticism at the h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Production of easily recyclable co-extruded sheets based in the use of a renewable biopolymer as inner layer' in the context of a Fifth Framework call.

assistant: **Objectives**

Complex co-extrusions offer good barrier properties against water vapour, gases and aromas, together with outstanding mechanical properties. During extrusion and vacuum forming a lot of waste is produced. For several years now the SME propose shave been looking at different technical solutions to efficiently separate the different co-extruded layers in order to recover and thus reuse valuable polymers, such as polystyrene. The proposed RTD work will focus on the production of easily recyclable co-extruded sheets based in the use of a renewable biopolymer as interlayer. The use of a biopolymer as inner layer in the food container sheets, can selectively facilitate the adhesion of layers - by dissolving it in hot water, for instance. A broad range of separation techniques is then available to separate the different layers. In this way, fabrication losses can directly be recycled and reprocessed internally leading to a reduction in waste (up to 40 %).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Form-frequency correspondences in grammar' in the context of a Horizon 2020 call.

assistant: **Objectives**

This project will document and explain a substantial number of grammatical universals by demonstrating a link between cross-linguistic patterns of language form and general trends of language use. The claim is that frequently expressed meanings tend to be expressed by short forms, not only at the level of words, but also throughout the grammars of languages around the world (form-frequency correspondences). A simple example is the asymmetry in the coding of present-tense forms and future-tense forms in the world’s languages, as one out of a multitude of analogous cases: Present-tense forms tend to be short or zero-coded, while future-tense forms tend to be longer or to have an overt marker. This corresponds to a usage asymmetry: Present-tense forms are generally more frequent than future-tense forms, in all languages. The proposed explanation is that higher-frequency items are more predictable than lower-frequency items, and predictable content need not be expressed overtly or can be expressed by shorter forms. Form-frequency correspondences thus make language structure more efficient, but it still needs to be shown that there exists a mechanism that creates and maintains these efficient structures: recurrent instances of language change driven by the speakers’ preference for user- friendly utterances. The project thus combines cross-linguistic research on grammar, cross-linguistic corpus research and historical linguistics in a ground- breaking way. For reasons that have to do with the history of the discipline, form-frequency correspondences are still largely overlooked and ignored by linguists, so the current project will have a significant impact on our general understanding of human language.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Assessing the agency of national minorities through court cases: mapping legal mobilization patterns in CEE'.

assistant: **Objectives**

The heavy involvement of the EU in the field of minority rights during the EU enlargement process to Central Eastern Europe (CEE) fostered the impression that problems related to national minorities had been largely resolved by the time the respective states joined the Union. By contrast, recent research indicated that the level of minority rights protection seems to have stagnated or even deteriorated in the post-accession period, which is counterintuitive to the positive expectations that followed these countries’ EU integration. The argument put forth here is that scholarly accounts of minority rights in the region focus too much on the role of international protection while treating minority representatives as disempowered actors to be defended, and failing to consider their potential for action to assert the rights that formally belong to them. The project’s interdisciplinary approach, combining legal studies with political science, will produce the first account of the agency and legal mobilisation of minorities in CEE, moving forward the scholarly debate beyond the current emphasis on structural conditions. The proposed research will therefore investigate the situation of minority rights through the lens of litigation and legal mobilization in two new EU Member States, Romania and Hungary and an EU candidate country, Serbia. The proposed project addresses four major, closely inter-related research questions: Which rights these minorities have claimed through litigation and which they have not, and what could explain their activism in some cases as opposed to others? Which legal mobilization strategies have led to favourable court decisions, which have resulted in negative rulings and what are the main factors accounting for these outcomes? Why some rights given b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Ultra low emission vehicle - transport advanced propulsion ii' to be submitted under Fifth Framework.

assistant: **Abstract**

The ULEV TAP II proposal is submitted in response to the Growth 2001 call for proposals. It addresses the objectives of KA 3: Land Transport and Marine Technologies with respect to Critical technologies for road and rail transport" and "New land transport vehicle concepts enhanced systems efficiency". The ULEV - TAP II consortium with four industrial partners in the transport sector, two universities with international reputation, one transport consultancy and seven European demonstration sites seeks for technical solutions to improve regional passenger transport systems in urban and suburban areas.The result will be a hybrid power train with following characteristics:- environmentally suitable (less noise, less pollutants) - energy efficient (40% less)- cost efficient (30% less)- meeting the market demand (in Europe and worldwide) More specifically the innovative vehicle concept will provide:- prime mover unit with high performance but low emissions- power booster energy recovery unit with minimum weight and size but maximum performance- a drive brake unit with maximum increase of the efficiency- a vehicle all supply for electric power control on various supply conditions all based on a modern, innovative, low-floor vehicle platform."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Geometric approach to many-body quantum chaos' (GeoChaos).

assistant: **Innovation**

Quantum chaotic dynamics is in the focus of many current developments in physics, ranging from thermalisation in closed quantum systems to the black hole information puzzle. Recently, experimentalists have made great strides in controlling quantum dynamics, and theorists have developed solvable models to study many-body quantum chaos. To uncover what aspects of these results are universal and how different chaotic phenomena across time scales are related, a coherent framework unifying and extending recent developments is called for. This project will develop two new paradigms that unify different manifestations of quantum chaotic dynamics and bridge disciplines.In the quest for a common dynamical explanation of different chaotic phenomena, we will construct a Unified effective field theory (EFT) for chaos. In parallel, we will capitalise on the holographic Gauge/String duality that gives geometric insights into strongly coupled quantum dynamics to draw connections between gravity and chaos. By developing a holographic dictionary between the Unified EFT and gravity, we will build the Chaos/Gravity correspondence, a novel framework that uncovers how spacetime and its gravitational dynamics emerges from chaos in quantum field theories.Our methodology consists of exact analytical computations in solvable models, the study of chaotic phenomena in universal kinematic regimes, and the description of these results in the framework of EFT. These steps lay the foundations for conceptual leaps to the Unified EFT and the Chaos/Gravity correspondence that will be pursued in synergy. The two new paradigms will transform our understanding of many-body quantum chaos. The benefits of a systematic approach will be multifold: we will establish new quantitative relations between data chara
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Training Network for Optimizing Adoptive T cell Therapy of Cancer'.

assistant: **Objectives**

Over the last years, immunotherapy  using a patients own immune system to fight tumours  has emerged as an important complement to standard treatments. The clinical implementation of immunotherapeutics has established T cells as efficient anti-cancer weapons if targeted by specific drugs. Their therapeutic utilization has recently come to a breakthrough: adoptive T cell therapy (ACT), collecting and transforming the patients own T cells to treat cancer. An estimated 753 different cell therapies are currently in development, of which 375 are in clinical trials worldwide. The global cell therapy market was valued at $2.70 billion in 2018 and is expected to reach $8.21 billion in 2025. While European pharmaceutical companies and research institutions rank amongst the world leaders in basic and preclinical aspects of immunity including cell therapy development, clinical innovations and approvals in this field have largely been pioneered in other countries, especially in the USA and in China.  The generation of such ACT products is a complex but ill-defined process with limited harmonization across production and clinical studies, even for the same indication. Cytokines are proteins responsible for the growth and differentiation of T cells. They are central to the generation procedure, whilst also playing a key role in the efficacy and safety of the cellular product. There is however a limited understanding as to which cytokines might lead to the best outcome on any of these steps. T-OP targets a pioneering research question: how do cytokines influence the therapeutic outcome of ACT products?  T-OP brings together interdisciplinary and cross-sectorial teams spanning large and small-sized companies as well as experts in different aspects of cell therapy, immunology, protein e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Smart Metal Organic Frameworks for Sensing Volatile Organic Compounds' under Horizon 2020.

assistant: **Concept**

SmartMOFs targets a new generation of Metal Organic Frameworks (MOFs) for sensing harmful volatile organic compounds (VOCs). The innovation of SmartMOFs is based on a combined sensing approach, where both optical and electrical changes in the MOF material enable the recognition event. The primary step to meet the required combination of specific absorption/emission and conductivity properties is the selection of the MOF structural units, supported by theoretical investigations. The selected units will offer extensive connectivity, flexibility, tunable porosity and functionalization of the inner surface of the network, with groups interacting with the analytes by means of coordination bonds, p-p interactions or hydrogen bonds. Harmful volatile compounds will entail gases and solvents (e.g., alcohols, benzene, hexane, cyclohexane). The SmarMOFs sensors will show increased selectivity and sensitivity with respect to the state-of-the-art. Deposition of the new MOF materials on surfaces to create sensor devices will be accomplished by advanced deposition techniques. SmartMOFs will thus overtake the current bottleneck of processability that limits practical applications of these materials, filling the gap between basic research and marketable applications. The high interdisciplinarity of SmartMOFs and its foreseen applications in the highly relevant area of public health will be a springboard for the Experienced Researcher to start a successful career in the academic or industrial sectors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Molecular by-pass therapy for mitochondrial dysfunction - Proof of Concept'.

assistant: **Innovation**

Defects in the primary metabolic functions of mitochondria, the cell’s‘power-plants’, underlie a diverse range of human pathologies, includingrare neuromuscular syndromes, many cases of common multifactorialdiseases (e.g epilepsy, deafness, diabetes), neurodegenerativeconditions such as Parkinson’s disease (PD), and devastating metabolicdisorders of infancy. Mitochondrial dysfunction is also a major cause oftissue damage in heart attack and stroke, and is involved incancer progression. This project will facilitate an R&D effort todevelop a common genetic therapy for this vast range of diseases, takingadvantage of the fact that lower organisms possess a built-inbiochemical mechanism for relieving the stress caused by mitochondrialdysfunction, using alternative respiratory chain enzymes that simplyby-pass the problem. Under ERC Project 232738 (MITO BY-PASS) we havesucceeded in expressing the alternative oxidase AOX from the seasquirt Ciona intestinalis in mammalian cells and transgenic flies. Inthe fruit-fly, AOX expression overcomes the lethality of poisonsdirected at mitochondria, and cures flies of genetic defects thatproduce features equivalent to PD or fatal mitochondrial diseases ofinfancy. Preliminary data on mammalian models also indicates that thegene can be safely expressed, and contributes similar benefits. Thesenow constitute a key validation tool to test the potential for AOXtherapy of many human diseases. This PoC project will undertake thecrucial next steps in the development of AOX therapy by implementing apartner search and negotiating terms for testing the technology in manydifferent mammalian models of common diseases associated withmitochondrial dysfunction, and by soliciting major investment forthe development of AOX therapy from both public and priva