RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Generation and Evolution Of Transform-Ridge Interaction and Behavior on Earth' (GEOTRIBE).

assistant: **Innovation**

Transform-ridge orthogonal patterns are fundamental features of the Earth’s plate tectonics. Although transform faults play a critical role in the organization of plate motions and are seismically active boundaries, it is still enigmatic how they form and why they are maintained. So far, only regional-scale models of transform fault inception and evolution exist. As the result, relationships of these structures with global mantle flow and large-scale plate kinematics remain unknown. The aim of this project is to advance our knowledge on global physical controls for the transform-ridge systems inception, dynamics and variability. I will take into account global forces to investigate nucleation and evolution of transform-ridge interactions, thus bridging the gap between regional and global models. I will use my long-term expertise in geophysical modeling to implement new physics (such as rock damage and magmatism) in the state-of-the-art convection code developed at ETH Zurich. I will run high-resolution 3D spherical models of global mantle convection to build the first database of simulated global transform-ridge patterns showing what factors influence the spacing and offset of transform faults. I will develop methods to compare the synthetic data with collected observed field data (bathymetry, gravity data, seismicity) to assess which physical processes (e.g. crustal melting, rock healing) control the formation and distribution of ridge-transform centers. Accounting for the global mantle and plate tectonic forces to explain transform fault dynamics is an unprecedented approach that is possible only now due to advances in physical properties of mantle rocks, numerical technics and increasing available computational power. Through this multidisciplinary project I aim at t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Network of European centrifuges for environmental research' (1994-1998).

assistant: **Innovation**

Training is an important aspect of the proposed project. Networking should centrifuge physical modelling and this experimental method has known a provide opportunity to young researchers and teams only recently engaged in centrifuge modelling to gain benefit from more experienced teams significant spread all over the world during the past fifteen years. Many new centrifuges have been set in operation in different countries.If the: Two kinds of actions are planned- training of permanent staff (researchers, engineers and technicians) of most fruitful applications have been up to now in the field of geo-technical engineering and soil/structure interaction problems, physical the centrifuge teams by short stays, participation to cross-tests and modelling appears to be also very promising in environmental engineering workshops;- training of young researchers by long stays among foreign teams and with already applications to heat and contaminant transport problems in participation in the joint research programme soils. In the European countries there is an increasing concern with environmental soil related problems (contaminant transport, waste containment, soil cleaning) and with respect to present knowledge physical centrifuge modelling seems to be a valuable tool for experimental investigation of complex situations where soil conditions are essential for the understanding of contaminant transport processes, and for a proper validation of theoretical numerical models. However research is still needed to reach these goals and international cooperation is obviously necessary since in many countries there is only one large geotechnical centrifuge facility. In order to develop the capabilities of centrifuge modelling in environmental engineering and to assess its limits, a limit
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Ex vivo treatment with recombinant CD4: a new therapeutic approach to AIDS' (1994-1998).

assistant: **Concept**

To demonstrate the technical viability of a medical device for accomplishing the selective immunodepletion of HIV virus and HIV antigens from the plasma of HIV infected patients.The medical device consists of a specialized immunoabsorption unit coupled with a standard plasmapheresis apparatus. This type of ex^vivo treatment will not deplete HIV infected cells, but only free HIV virions and HIV antigens/immunocomplexes, therefore clinical benefits are expected only by using the treatment on a regular basis and in combination with other standard HIV therapies. Economical calculation of the cost of treatment session will be performed.The immunoabsorption unit consists of a closed filter system bearing one or more ligands specific for the HIV envelope or for immune complexes, both of which are abundant in HIV infected patients and which contribute to pathogenesis. The immunoabsorption unit will contain recombinant CD4 (CD4 is the natural receptor for HIV) and will deplete both HIV virions and HIV envelope antigens. Another type of immunoabsorption unit produced will contain anti-envelope monoclonai antibodies which, similarly to CD4, directly bind both soluble and virionic envelope antigens.Other ligands will be used as alternative to CD4 and anti-gp120 antibodies. These ligands will be tested in parallel outside of the contract and will be used for manufacturing the immunoabsorption units only if the testing will demonstrate in vitro efficacy. These alternative ligands are anti-HLA antibodies, which recognize virionic HLA moiecules, complement factor C1 q which has a high affinity for polymeric immunoglobulins like those present in antigen/antibody complexes, GNA lectin which has been recently shown to bind with very high affinity HIV gp120.The project is divided into two
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RANDOMIZED EVIDENCE OF PSYCHOSOCIAL INTERVENTIONS IN CHILDREN EXPOSED TO TRAUMATIC EVENTS IN LOW AND MIDDLE INCOME COUNTRIES' to be submitted under Seventh Framework.

assistant: **Abstract**

The applicant is a clinical psychologist whose overall research aim is to link the results of primary research to everyday clinical practice in order to guide mental health care professionals to take evidence-based decisions in promoting human wellbeing. To reach this objective it is necessary to synthesize randomized evidence on the effectiveness of clinical interventions using rigorous standards. The specific research objective of the proposed plan focuses on the effects of psychosocial interventions for children exposed to traumatic events in humanitarian settings in low and middle income countries (HS-LMIC). Literature in this field shows potential effectiveness of such interventions but currently available evidence needs to be strengthened by more rigorous evidence-based evaluation and implementation programs. The proposed research aims to assess the effectiveness of psychosocial interventions for children exposed to traumatic events in HS-LMIC. Additionally, the study will examine whether clinical and socio-demographic characteristics, trauma-related variables, and cultural aspects may act as moderators of treatment effect. Finally, evidence-based profiles on the treatments of this specific population will be developed.In relation to the aforementioned research aims, the educational part of the proposal includes: 1) a specific training in the evaluation of psychosocial interventions for children exposed to traumatic events in HS-LMIC in the Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore; 2) a specific advanced training in evidence-based mental health, research methodology, and epidemiology in the World Health Organization Collaborating Centre for Research and Training in Mental Health and Service Evaluation, Section of Psychia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Fostering research careers in LIGHT sciences' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

FLIGHT is a 60-month MCSA COFUND doctoral program that aims at recruiting outstanding early stage researchers (ESRs) to carry out ambitious PhD-projects at ICFO in one of 3 tracks: Standrard, Industrial or Clinical. It will offer 30 highly competitive fellowships of 36 months duration, through 3 calls, to outstanding international candidates, and equip them unique capabilities to become future leaders in academic, industrial and clinical research.FLIGHT aims to fostering career mobility of researchers beyond the academic sector. The program includes an extensive training program of multidisciplinary scientific workshops and training events where all Fellows are exposed to the interdisciplinary mix between academic research and industrial/clinical work. ESRs in the Industrial and Clinical tracks will undertake research projects in collaboration with one of 14 Industrial and Clinical partners, from innovative start-ups to multinational companies and leading local hospitals, who will co-finance the ESRs' research projects, and provide co-supervision, extended secondments, research and training resources.FLIGHT will equip recruited Fellows with unique capabilities to launch a research career at the intersection of photonic sciences with a wide range of industrial and clinical applications, and enhance the European talent base in a field – photonic sciences – identified as vital to the ongoing competitiveness of the European Research Area.


**Keywords:** Photonic Sciences, Industry, Clinical Sciences, Intersectoral, Interdisciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'OPTIMIZED COLLECTIVE ENERGY SUPPLY FOR DHW AND HVAC IN SMALL RESIDENTIAL AREAS CONSTRUCTED'.

assistant: **Objectives**

The overall objective of this project is to design, erect, monitor and demonstrate two collective heat supply systems for 20 flats and 16 dwellings in a new housing estate Hofanlage Brombeerweg" (DE) which is a certified EXPO 2000 project. The primary aim is to achieve a total energy reduction of 28% (plant 1) and 36% (plant 2) when compared to the reference plant. The energy reduction will be achieved by the following combination of technologies: - plant 1 : heat generated by a condensing unit, supported by solar collector system (vacuum solar pipes), central heat storage tank for the peak heat demand, decentralized heat exchangers and an innovative control software (DDC).- plant 2 : two small gas fired cogeneration units, low temperatures gas boiler to cover peak heat demand, storage tanks with integrated small heat exchangers and an innovative control software (DDC).The monitoring and evaluation phase is estimated to take 29 months and the results will be disseminated. This project is estimated to take 2.9 years in total to complete all phases and additional benefits will include an estimated reduction per annum of 10.169 kg/a (plant 1) and 14.728 kg/a (plant 2) CO2.This project demonstrates innovative technology for the collective heat supply in low energy house areas with small energy demand. Two separated collective heating systems supply 10 flats in a living block and additional 8-10 dwellings each. The project coordinator Wesertal will plan, erect and operate these two heating plants by contracting. In spite of the high innovative efficient enegry saving technique the initial invetsment costs will still be very low for each flat/house owner, compared to today's decentralized solutions.In plant 1 heat will be generated by a condensing gas unit, which will be supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Supporting Architectural and technological Network evolutions through an intelligent, secureD and twinning enaBled Open eXperimentation facility' under Horizon Europe.

assistant: **Concept**

The 6G-SANDBOX project brings a complete and modular facility for the European experimentation ecosystem (in line and under the directions set by SNS JU), which is expected to support for the next decade technology and research validation processes needed in the pathway towards 6G. The target is at technologies and research advances, that span over the entire service provisioning chain, and refer to user/data, control and management planes. In this direction, 6G-SANDBOX introduces the concept of Trial Networks, which refers to fully configurable, manageable and controlled end-to-end networks, composed of both digital and physical nodes. The 6G-SANDBOX Trial Networks incorporate infrastructures distributed in EU (namely in Malaga, Athens, Berlin and Oulu) and offer to third parties (including experimenters from open calls) automated experimentation capabilities through a rich and extensible toolbox. Meant to create tangible and long-term impact, the 6G KPIs and KVIs that will be quantified with the facility, will be released to any interested party; while the set of developments and APIs that will be produced, will feed an open repository as an initial step to move the contributions and the lessons learned beyond the project boarders and define a European 6G library.


**Keywords:** Experimental infrastructure, Test & Measurement, Internet of Sense, Disruptive wireless, Deterministic Networking, fixed/RAN/NTN integration, standarization towards 6G , digital twins,BY5G, KPIs&KVIs
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Regulation of transcriptional activators by the rb and mdm2 oncoproteins'.

assistant: **Innovation**

The oncoprotein MDM2 and the tumour suppressor RB are important regulators of transcription factors (TFs): MDM2, for instance, inhibits the activity of p53, a TF that induces growth arrest or apoptosis upon DNA-damage, whereas RB inhibits - amongst others - the activity of E2F, a TF that promotes cell division. A precise control of these processes is a prerequisite for a reliable cell division with an intact genome. We found that MDM2 stimulates E2F and that RB interacts with p53. Therefore, it shall be investigated how MDM2 and RB regulate p53 and E2F, TFs with acidic activation domains, and how this affects cellular processes like growth control and apoptosis. Since we found that MDM2 can also interact with and activate the TF AP1, but not SP1, a TF with a glutamine rich activation domain, it shall be investigated, whether MDM2 is a general adaptor molecule of transcription. Finally, a library screen using the yeast two hybrid system shall be carried out to identify further molecules interacting with and regulating the activation domain of E2F1. The findings of this project should contribute to the understanding of the nature of cancer and to developing new drugs for treatment of various types of this disease.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Targeting Glioblastoma using Combinatorial Therapeutic Nanovaccine'.

assistant: **Innovation**

The proposal aims at the synthesis, characterisation and application of a novel therapeutic nanovaccine (TNVax) that holds multiple modules for targeting glioblastoma multiforme (GBM). The proposed TNVax formulation includes a gold nanocage core encapsulating Temozolamide (TMZ), coated with an extremophilic bacterial polysaccharide, mauran functionalised with anti-PD-L1 antibody and anti-CD133 antibody. The us of NVax nanoparticles (NPs) offers a combinatorial approach in killing GBM cells both by immuno- and chemo- therapeutically. Site-specific delivery of the payload will stimulate the host immune system and channel the immune cells to the target site. Functionalisation of the anti-PD-L1 antibody on drug-encapsulatedNPs would significantly alter the immune suppression caused by GBM cells on TNVax delivery. In addition to anti-PD-L1 antibody, the TNVax particles contain tumour specific monoclonal antibody that specifically recognizes CD133 antigen and facilitates strong binding. This approach would enhance the amount of antitumour activity offered by multiple means and thereby leaving a strong immune response against GBM based on antigen-antibody interactions. TNVax NPs will be synthesised and characterised using microscopic and spectroscopic techniques and then subjected to in vitro and in vivo evaluations. In vitro studies will be performed for drug release kinetics and cytotoxicity using immunofluorescence and FACS analysis. Induction of immune response by TNVax NPs will be evaluated using macrophage activation, induction of T-cell activity and cytokine production under in vitro conditions. The pharmacokinetic and pharmacodynamic studieswill be carried out and histopathological examinations performed using appropriate murine models induced with GBM cell lines. The
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The folding of membrane proteins - influence of lipid lateral pressure' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Research objectives and content The aim of the research described in this proposal is to determine the influence of lipid lateral forces in membranes on the folding, stability and enzymatic activity of membrane proteins. As a model system we will use bacteriorhodopsin in combination with lipid bilayers consisting of mixtures of the C6-chain lipid dihexanoylphosphatidylcholine (DHPC) and the C14-chain lipid dimyristoylphosphatidylcholine. In this system the lateral pressure exerted by the lipid molecules on the protein can be can be controlled by varying the molar ratio of the two components. We will determine a) the physical properties of the bilayer in varying compositions and in the presence and absence of the protein and b) the folding properties, stability and activity of the protein as a function of changes in the bilayer composition. The physical properties of the bilayer (a) will be determined by differential scanning calorimetry, isothermal titration calorimetry, excimer fluorescence of inserted di-pyrene probes and X-ray diffraction. The folding properties and activity of the protein (b) will be determined spectroscopically (fluorescence, absorption and circular dichroism). The stability of the protein (b) will be evaluated using differential scanning calorimetry. Training content (objective, benefit and expected impact)  There is good complementarity between the skills of the applicant and the training provided by the host institution, and therefore both will benefit from their cooperation. The applicant brings experience in the use of calorimetric techniques in combination with membrane proteins as well as a an understanding of the thermodynamics of protein stability. The host institute will provide training in the use of time-resolved techniques in the study