RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Safety and efficacy of tauroursodeoxycholic acid (TUDCA) as add-on treatment in patients affected by amyotrophic lateral sclerosis (ALS)' under Horizon 2020.

assistant: **Concept**

TUDCA-ALS will focus on amyotrophic lateral sclerosis (ALS) a rare neurodegenerative disorder, that affects motor neurons in the brain, brainstem and spinal cord, resulting in progressive weakness and atrophy of voluntary skeletal muscles. ALS has an estimated prevalence of 5.40 cases per 100.000 population corresponding at about 40.000 patients at European level. Treatments are modestly effective at best, and the majority of patients die within 3-5 years of diagnosis, often from respiratory failure.TUDCA-ALS is based on the results of a successful proof-of-concept trial and has the ambition to develop a novel therapy in patients with ALS, based on administration of tauroursodeoxycholic acid (TUDCA) in addition to riluzole. TUDCA-ALS aims to perform a state-of-art randomized control trial on safety and efficacy of TUDCA in patients with sporadic ALS, without cognitive involvement and to exploit the project results into a novel therapeutic treatment for ALS. The trial primary endpoint is deterioration of function measured with the ALS Functional Rating Scale Revised. The secondary endpoints are: (1) Survival time to invasive ventilation (tracheostomy) or death; (2) changes in quality of life parameters measured by the ALSAQ-40 questionnaire; (3) functional changes measured by Forced Vital Capacity, and the EQ-5D scale. Muscle force will be assessed by the MRC scale and a correlated analysis of function and survival will be performed. Two biomarkers will be measured: neurofilament levels in the CSF and serum and MMP-9 expression in serum. The latter is a possible biomarker of TUDCA efficacy. TUDCA-ALS is grounded on promising phase IIb clinical data and is expected to impact positively on the international research efforts on ALS.TUDCA-ALS aims to obtain concrete benefits
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'FogsScreen Mini - breakthrough laminar air purification technology with stunning interactive images' (2014-2020).

assistant: **Concept**

FogScreen Mini is a unique home and office air purifying device that projects stunning interactive images onto a screen of vapour. It uses breakthrough laminar circulation technology to purify and humidify an entire room more effectively and quietly than current devices. The purified air stream creates a curtain of fog, which is used to present responsive hologram-like images for entertainment or promotion. By adding visuals to air sanitation, the FogScreen Mini will stimulate the large-scale take-up of air quality technology, improving the health of residents and office workers in polluted urban environments worldwide.The demand for indoor air purification systems is growing rapidly due to poor urban air quality, resulting in respiratory problems and general poor health. All existing purifiers use turbulent circulation, which is ineffective and noisy. FogScreen Mini is pioneering laminar air flow technology, which distributes clean air and captures particles more effectively. Tests show the FogScreen Mini collects at least 25% more particles and is 50% quieter than the nearest competitor.Customers are residents and office managers seeking to improve air quality. The market for air filtration technology is estimated to reach $US20.65B by 2020. The company will partner with electronics manufacturers. One Chinese distributor is already in negotiations.Fogio has already created a prototype unit, proven the technical concept and shown quantifiable benefits. It holds worldwide patents for the innovation. The company has a team of 11 experienced professionals, including technology experts to develop innovations, and a sales team with international networks. Within five years, Fogio forecasts total unit sales of 2.8 million, generating €790 million in revenue, scaling up to 30
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Development of new therapeutic treatments targeting cancer stem cells.' (StemTarget), addressing dissemination and exploitation.

assistant: **Impact**

Acute myeloid leukemia is characterized by the accumulation of transformed immature myeloid cell in bone marrow. The course of the disease is marked by poor prognosis, frequent relapse, and high disease-related mortality. In spite of improvements in its therapy, above 60% of AML patients will eventually succumb to the disease, a fact stressing the need for new therapeutic approaches for remission induction and prevention of relapse. The difficulty in treating AML is thought to arise from a chemoresistant subpopulation of leukemia stem cells (LSCs) that are capable of maintaining and reinitiating the disease. Increasing evidences suggest that classic neurotransmitter receptors such as dopamine receptors (DRs) and serotonin receptors (HTRs) are involved in cancer genesis and maintenance. Indeed, DRs and HTRs are expressed on the surface of LSCs. By killing differentially LSCs while sparing healthy hematopoietic stem cells (HSCs), DR/HTR antagonists could constitute a new therapeutic target for AML, especially for eradication of LSCs.


**Keywords:** cancer stem cell, serotonin receptors, leukemia, cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Relative representation theory and distributions  on reductive groups over local fields'.

assistant: **Concept**

One can view the representation theory of a topological group as non-commutative harmonic analysis on the group. For compact groups this view is justified by the Peter-Weyl theorem. The relative representation theory of a group is harmonic analyses on spaces with transitive group action.I work in relative representation theory of reductive (algebraic) groups over local fields, e.g. the general linear group over the  field of real numbers or the  field of p-adic numbers. This theory has applications to the theory of automorphic forms, in particular to the relative trace formula. There are many similarities between the real and p-adic cases, and some results can be formulated uniformly for all local fields, but their proofs are usually specific to each type of local fields.  An important tool in this theory, that is applicable for all local fields, is the analysis of equivariant  distributions on the group. However, this analysis is quite different for the two kinds of fields. In the first part of this proposal I describe my ongoing work on some tools that will help to  approach invariant distributions uniformly for all fields. I also propose to advance, using those tools, towards the proofs of some long-standing conjectures on density of orbital integrals, comparison of Lie algebra homologies, and classification of (non-compact) Gelfand pairs. The second part of this proposal concerns generalized Whittaker models, or equivalently harmonic analyses on the quotient of a reductive group by a unipotent subgroup. In 1987 Moeglen and Waldspurger comprehensively described the role of a representation in this harmonic analyses in terms of a certain collection of nilpotent orbits attached to this representation. This result, as well as previous results on Whittaker models have ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'CONQUEST: Enabling advanced medical imaging' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

CONQUEST: Enabling advanced medical imagingCONQUEST is formed around a new imaging technology platform. The basis is the newly developed nanoparticles function as contrast agents for a variety of imaging modalities that are presently used in healthcare such as ultrasound and MRI. In particular, the nanoparticles are a completely novel type of contrast agent for ultrasound imaging. The high stability and long shelf life of the particles combined with visibility in ultrasound could allow application of ultrasound imaging in areas currently dominated by more expensive, more difficult and slower imaging modalities such as MRI, PET or SPECT (nuclear imaging techniques). Moreover, ultrasound is already widely available, does not involve ionizing radiation and is the most “user-friendly” clinical imaging modality. Furthermore, the unique properties of the CONQUEST nanoparticles may allow its targeting to regions of inflammation, including malignant tumours and unstable atherosclerotic plaques. Initially, we will focus on the application of CONQUEST agents to the diagnosis of focal liver lesions. Currently, through the linked ERC StG, GMP-grade particles are available and approved for testing in a cell therapy clinical trial. In all, at the end of this proposal, we expect to have solid in vivo proof of the viability of the agent in focal liver lesions (selected as our first application based on market research), and a strengthened IP position. This will put CONQUEST in a strong position to acquire the large amounts of funding necessary for full clinical validation, and the eventual introduction of new applications and new products. Thus, with this technology platform we can create a new market (for multimodal imaging agents), improve efficiency and reduce costs in healthcare.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'A smart pellet stove that combines efficient heat generation with IoT' (2014-2020).

assistant: **Concept**

Laelia Due is a smart pellet stove that combines efficient heat generation with IoT designed and developed by Vesta (Italy). Laelia Due addresses the opportunity in the EU pellet stove market created by fierce price-based competition and lack of innovation in the past years. For the current TRL6 prototype Laelia Due has reached 86% efficiency & 0.39g/hour PM emissions (minimal power), with 92-96% efficiency forecasted at TRL9. Thanks to IoT components Laelia Due integrates with 3rd party smart home appliances, collects its performance & surrounding air quality data & provides revenue-generating value-added smart services. The smart stove allows placement of installation orders from the local service providers, remote monitoring, diagnostics & preventive maintenance of the stove; user notifications on the quality of pellets & automatic adjustment of burning temperature (with notifications); measurements of the indoor air quality, automatic notifications & emergency shutdown and notifications on pellet consumption rates & automatic pre-orders of the resupplies from local providers.In 2015 360K pellet stoves were sold in EU. There are ~2.5M pellet stoves installed in EU. With the average sales price of a pellet stove (together with installation) €3-3.5K and the planned 20% discount, Laelia Due can bring in ~€96M annual revenue in Italy and ~€144M in total EU by 2025.To commercialise Laelia Due, Vesta will engage users via a dedicated mobile e-commerce channel (smartphone app), inform them about the correct heating approaches and air pollution issues, allow them to configure and visualize the stove in their interior using the augmented reality, and sell it directly, circumventing the middlemen and putting price pressure on competition.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bordism of symmetries: From global groups to derived orbifolds' (BorSym) under Horizon Europe.

assistant: **Objectives**

Bordism theory connects many central areas of mathematics: Defined via smooth manifolds, it has proved to have deep connections to formal groups from algebraic geometry and stable homotopy theory from algebraic topology. In particular, complex bordism serves as an effective organizational tool for studying the stable homotopy category, splitting up the homotopy groups of spheres into components of different wavelengths.The goal of BorSym is to develop a similarly powerful correspondence that classifies the symmetry of spaces through novel connections to equivariant algebraic geometry and smooth actions. While such a relationship for symmetries has long been conjectured, it was only recently that foundational results have been established for the actions of abelian groups, such as the tensor-triangular classification of actions on finite complexes and my proof of the equivariant Quillen theorem. At the same time, bordism of symmetries has become a central object of interest also in the seemingly unrelated field of symplectic topology, where groundbreaking work of Abouzaid and collaborators has identified derived orbifold bordism as the universal target for Floer homology, thereby solving long-standing open problems in the field. In view of these events a new picture is emerging which paints a universal role of equivariant bordism, going substantially beyond even its classical role described above. The goal of BorSym is to unravel the full potential of this emerging picture: to thoroughly develop a chromatic homotopy theory of group actions; to employ the newly established set of tools to tackle major open problems in transformation groups and obtain new information about the derived orbifold bordism ring; and to extend the connections between formal groups, thick subcate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Advancing Sustainable Urban Transport in an Enlarged Europe through CIVITAS' (VANGUARD).

assistant: **Innovation**

CIVITAS VANGUARD will assist the EC Directorate for Transport and Energy in coordinating the “CIVITAS-Plus” phase of its “CIVITAS Initiative” for cleaner and sustainable urban transport, as well as to assist in the dissemination of CIVITAS-Plus results. The project will be implemented by a consortium consisting of European city networks as well as transport, energy and policy oriented organizations and a communications company.Activities will commence with a needs assessment conducted among the CIVITAS-Plus demonstration projects and a broader audience. This will be followed by a ‘Service and Support Strategy’, outlining the target groups, approaches and benefits as well as the areas where coordination and support will be given to demonstration projects. Examples include the continuation and enhancement of a Dissemination Liaison Group, the compilation of individual dissemination tools and the facilitation of information flow. Based on the specific needs of the cities, dedicated working groups and training sessions will be organised, along with comprehensive marketing support. CIVITAS VANGUARD will raise the awareness, disseminate and market the results of CIVITAS-Plus demonstration projects to a wide audience of urban transport practitioners, located in all member states of the enlarged European Union.An ‘Awareness-raising, dissemination and marketing strategy’ will be developed, outlining in detail the communications products and services of CIVITAS VANGUARD. As the central information hub, the CIVITAS website will be maintained and further developed. A range of promotional materials will be produced. Direct support to the CIVITAS Initiative beyond the demonstration cities will be provided through the hosting of the CIVITAS Secretariat and that of the CIVITAS Politica
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Studies on distribution and variability of water vapour concentrations on base of remote sensing and in-situ data' under Sixth Framework.

assistant: **Concept**

The water vapour plays a major role in the balance of planetary radiation, influences and responds to atmospheric motions and plays a key role in many aspects of atmospheric chemistry. It is emphasized that an increase of water vapour causes a cooling of the lower stratosphere that is comparable to the contribution due to ozone changes. In view of the potential effects on climate change it is important to assess reciprocal relationship between water vapour and climate change. Water vapour measurements have been difficult. In situ ones suffer from water sticking to surfaces, while sharp gradients present difficulties for remote sensing techniques. The analysis of remote sensing data is additionally complicated by a lack of understanding of the fundamental physics behind the observed spectrum. To rise to the task, the researcher proposes to tap both, the remote sensing and in situ data. Satellite data sets enable characterising large-scale variations of water vapour. In situ and ground-based data sets make possible the investigation at smaller spatial scales, for long-term monitoring and for validation of satellite data. Mean distribution of the gas, its seasonal, non-seasonal and long-term variations will be considered including the dependence on macro circulation patterns. The project will allow the researcher an advanced training in the host organisation, especially in satellite data validation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'ASSESSMENT ON ALTERNATIVE AVIATION FUELS DEVELOPMENT'.

assistant: **Concept**

It is widely accepted that the use of sustainable fuels, with a Life-cycle carbon footprint substantially smaller than the present fossil-origin kerosene, is the most promising and probably the only short-medium time measure allowing the aviation industry to reduce its emissions, helping to reach 2015 Paris Agreement targets.During the last 10 years, many tests have been done with different drop-in organic products with high level of success. Present commercial aircraft engines are certified for using a mix of up to 50% of some of these new products. More additional research is still going on the convenience of developing new feedstocks and on their potential climate change impact.The International Civil Aviation Organization (ICAO) is now discussing the best way to standardise the Life-cycle Analysis (LCA) of the most readily available products and what is the best certification procedures. This process is needed in order to apply CORSIA (Carbon Offsetting and Reduction Scheme for International Aviation), approved in October 2016, intending to stabilize international aviation carbon dioxide (CO2) emissions at 2020 levels. However, none of those new organic-origin fuels has proved the means to be produced in an economically competitive way versus fossil kerosene. It is generally accepted that some type of incentive mechanism needs to be implemented to make sustainable fuel attractive for the airlines in addition to the CORSIA and European Trading System provisions.  As the result of this Chinese and European cooperation proposal, some possibilities appear for a wider aviation sustainable fuel utilisation, considering both technical and economic areas, including the possible use of more feedstocks and production pathways than the existing ones. New fuel candidates will b