RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a high-resolution method to monitor structural changes of regulatory RNAs and therapeutic oligo-nucleotides directly in-cell.' under Horizon 2020.

assistant: **Concept**

MicroRNAs (miRNAs) are master regulators in cells with a complexity yet to be unraveled. By targeting one or more messenger RNAs (mRNAs) they affect a vast number of biological processes and are associated with a broad spectrum of diseases, including cancer. This makes them potential candidates for cancer-diagnostics and -therapeutics. This opportunity can only be fully exploited by a better comprehension of how and when each mRNA is targeted by a miRNA, a fact, which is currently still poorly understood. Besides regulatory RNAs, synthetic “anti-sense” oligonucleotides (AONs) are currently tested as cancer drugs. Progress in this field has been slow due to unspecific off-target-effects i.e. the lack of understanding, of the mechanism of AONs targeting mRNAs. This project focuses on overcoming this lack of knowledge of the targeting process. To understand the intermolecular interactions occurring in the cell we will, for the first time, monitor the molecular structure and structural changes (dynamics) of nucleotides (miRNAs as well as AONs) in the living cell, and link these in-cell structures to the molecule’s targeting function. Combining existing knowledge of the host in structural and molecular biology of miRNAs with the experience in methods development in Nuclear Magnetic Resonance (NMR) of the experienced researcher (ER), we will develop a set of robust and reliable in-cell NMR methods to determine cellular concentration, structure and dynamics within the cell at high resolution. The scope of the method will be demonstrated on: (i) a miRNA, miR-34a, which targets more than 50 different mRNAs, related to cancer and other cellular processes, as well as (ii) an AON drug candidate in collaboration with AstraZeneca. This project will benefit drug development against va
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cytosolic recognition of foreign nucleic acids: Molecular and functional characterization of AIM2, a central player in DNA-triggered inflammasome activation' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Host cytokines, chemokines and type I IFNs are critical effectors of the innate immune response to viral and bacterial pathogens. Several classes of germ-line encoded pattern recognition receptors have been identified, which sense non-self nucleic acids and trigger these responses. Recently NLRP-3, a member of the NOD-like receptor (NLR) family, has been shown to sense endogenous danger signals, environmental insults and the DNA viruses adenovirus and HSV. Activation of NLRP-3 induces the formation of a large multiprotein complex in cells termed inflammasome , which controls the activity of pro-caspase-1 and the maturation of pro-IL-1² and pro-IL18 into their active forms. NLRP-3, however, does not regulate these responses to double stranded cytosolic DNA. We identified the cytosolic protein AIM2 as the missing receptor for cytosolic DNA. AIM2 contains a HIN200 domain, which binds to DNA and a pyrin domain, which associates with the adapter molecule ASC to activate both NF-ºB and caspase-1. Knock down of AIM2 down-regulates caspase-1-mediated IL-1² responses following DNA stimulation or vaccinia virus infection. Collectively, these observations demonstrate that AIM2 forms an inflammasome with the DNA ligand and ASC to activate caspase-1. Our underlying hypothesis for this proposal is that AIM2 plays a central role in host-defence to cytosolic microbial pathogens and also in DNA-triggered autoimmunity. The goals of this research proposal are to further characterize the DNA ligand for AIM2, to explore the molecular mechanisms of AIM2 activation, to define the contribution of AIM2 to host-defence against viral and bacterial pathogens and to assess its function in nucleic acid triggered autoimmune disease. The characterization of AIM2 and its role in innate immunity could o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'UTU-ESR Programme: Solutions for Green and Digital Transition' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

UTU-GreDiT is a unique international, inter-sectoral and interdisciplinary Doctoral Programme hosted by the University of Turku (UTU). The objective of UTU-GreDiT is to provide a top-quality research training ecosystem for 25 ESRs focusing on Green and Digital Transition to strengthen transformative change. It boosts transformative change towards sustainable societies and producing high-demand experts for the needs of public-private sectors and academia. The call of the UTU-GreDiT Programme will be published internationally and applicants will be evaluated through an open, merit-based process by external evaluators. The appointed ESRs will be full members of UTU Graduate School (UTUGS) with similar opportunities, obligations and working conditions to other UTUGS members. UTU-GreDiT will integrate cutting-edge research infrastructures, experienced supervisors, and existing knowledge base of 14 research groups with >45 professors and experienced researchers. This enables ESRs to gain high-quality training and perform novel research under interdisciplinary supervision that crosses research groups from UTU and associated partners on topics related to Green and Digital Transition, and European Green Deal. National or international 4-6 months secondments and other training activities are provided through 26 associated partners and UTU. UTU-GreDiT will provide transferable skills for ESRs including scientific writing, project management, culture of open science and entrepreneurial skills that are essential for widening their career prospects. The training and secondments offered will actively involve all participants, and thus, contribute to bridging the gaps between research and private sector and boosting the sustainable socio-economic growth from regional to EU level. After
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Promotion of geothermal energy utilisation in Turkey' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

Within the past years, the European Commission has supported a broad range of demonstration projects for the exploitation of European geothermal resources. The state of the art and the well developed geothermal applications in different member states have been mainly initiated through European RTD and demonstration programmes and numerous replications of successfully demonstrated technologies could be achieved. Aim of the proposal is to assess and to identify the excellent market opportunities of geothermal energy utilization schemes in Turkey from the technical and economical point of view, to select appropriate technology schemes and to develop and initiate a dissemination process in order to exploit the identified business opportunities for the European industries related to geothermal energy use.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'In silico haplotype visualisation and analysis - integrating genome biology and genetics' to be submitted under Fifth Framework.

assistant: **Abstract**

Linkage-disequilibrium (LD) mapping as a powerful tool for fine-mapping disease genes, the TSC have committed to produce a complete haplotype map of the human genome to enable large-scale LD mapping studies. The availability of this data set, calls for a unified tool for visualization of this haplotype data in the full genomic context, e.g. in relation to other SNPs, genes and other genomic information. No tools currently address the specific need to visualize haplotype data. This project proposes to develop tools to allow visualization and mining of haplotype data sets using Ensembl, a public genome visualization tool. All code generated, as part of this project will be contributed back to the public Ensembl project, in close collaboration with scientists at the EBI. In addition to developing tools to visualize haplotype data, we also propose to use the whole genome haplotype data set to perform a series of whole genome analyses to investigate the relationship between LD and physical and sequence-based properties of the genome. Large-scale genome analysis may be very informative, with a haplotype map as a reference it may be possible to estimate the extent of LD in a region based purely on human genome data, this ability may significantly enhance disease gene discovery. GSK bioinformatics has very substantial resources that will be fully available for use by the fellow. This includes access to modern powerful computing hardware suitable for studies of this scale. In addition to the academic and scientific aspects of this post. the fellow will have substantial personal development opportunities with full access to GSK training courses on IT skills, team working and personal development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Combination of ai techniques and software with advanced reactor equipment for efficient kinetics analysis in the chemical industry' to be submitted under Fifth Framework.

assistant: **Abstract**

The efficient and correct identification of the complex physico-chemical phenomena in chemical kinetics is fundamental for the optimal design of reactors and consequently for the overall process optimisation in the chemical industry and for the achievement of objectives such as product quality, energy saving, waste minimisation. This project proposes innovative and automated procedures, based on Al techniques, for better chemical kinetics identification in a reduced amount of time, using a limited amount of experiments and employing a reduced staff of scientists. The final result of this project is the development of a prototype, which will include innovative hardware (a fully automated temperature scanning plug flow reactor, with advanced control and data acquisition equipment) and software, based on formal reasoning (for the automated selecnon of nencs experiments, for the setting up of candidate reaction schemes and for the automated translation from the chemical into the algebraic language), numerical algorithms (for the identification of the parameters contained in the symbolic algebraic model) and powerful presentation graphics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Arrowhead Tools for Engineering of Digitalisation Solutions'.

assistant: **Objectives**

For the purpose of creating digitalisation and automation solutions Arrowhead Tools adresses engineering methodologies and suitable integrated tool chains. With the global aim of substantial reduction of the engineering costs for digitalisation/automation solutions. Thus the Arrowhead Tools vision is:   - Engineering processes and tool chains for cost efficient developments of digitalization, connectivity and automation systems solutions in various fields of application    For the further and wider commercialisation of automation and digitalisation services and products based on SOA, Arrowhead Framework and similar technologies there is a clear need for engineerings tools that integrates existing automation and digitalisation engineering procedures and tool with SOA based automation/digitalisation technology.      For this purpose the Arrowhead Tool’s grand challenges are defined as:   - Engineering costs reduction by 40-60% for a wide range of automation/digitalisation solutions.   - Tools chains for digitalisation and automation engineering and management, adapted to:  1. existing automation and digitalisation engineering methodologies and tools  2. new IoT and SoS automation and digitalisation engineering and management tools  3. security management tools  - Training material and kits for professional engineers  The results will create impact on: - Automation and digitalisation solution market - Automation and engineering efficiency and the SSBS market - Automation and digitalisation security - Competence development on engineering of automation and digitalisation solution


**Keywords:** Engineering of digitalisation solutions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Turbulence Modelling for Unsteady Flows in Axial Turbine Stages', explaining its relevance to EU policy priorities under Fourth Framework.

assistant: **Impact**

Objectives and content The project aims at providing a greater understanding of unsteady flow phenomena associated with turbine rotor-stator interaction and improved turbulence models that can be used in industrial codes for turbomachinery design. The project represents the first major concerted effort in this area and is seen by the industrial partners as a vital element in developing improved turbine design methods essential to ensuring future competitive products. Three major tasks are planned: - Examination of non-isotropic turbulence models and simulation techniques for prediction of unsteady wake flow features associated to wakes and wake-blade interactions.  This Task is trusted to 4 different University research groups. Non-linear 2 equation models, linear and non-linear Reynolds Stress Transport models and Large Eddy Simulation techniques will be examined and tested against experiment data provided by Task 2. Task 1 partners will make recommendations to Task 3 partners as to which models appear to be the most promising and the most suitable for unsteady turbine flow calculations. - Experimental test cases for assessment of turbulence models. Three turbomachinery laboratories are in charge of establishing 3 benchmark test cases, featuring strong unsteady flow effects: (I) unsteady turbine blade wake flows at high subsonic and transonic downstream velocities; (2) effect of coolant flow ejection on unsteady blade wake flow characteristics at low speed; (3) wake-blade interference simulated with a moving bar system in a low speed linear cascade. Emphasis is put on measuring the time varying wake and boundary layer characteristics. The experimental partners will provide the modelling partners with well documented data sets for code validation. - Unsteady 2-D and 3-D
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Coupled thermal-hydrological-mechanical-chemical processes for application in repository safety assessment' (THERESA) targeting Sixth Framework.

assistant: **Abstract**

This proposal aims to develop a scientific methodology for evaluating the capabilities of mathematical models and computer codes used in Performance Assessment and applied to the design, struction, operation, performance and safety assessment, and post-closure monitoring of geological nuclear waste repositories, based on the scientific principles governing coupled thermo-hydro-mechanical and chemical (THMC) processes in geological systems and geo-materials. The project work will be centrated on the most essential issues for PA, with focus on rock salt, buffer materials and the buffer-rock interface, as guided by the tool of Issue Evaluation Tables (IET). The evaluation will be carried out by scientific/technical auditing (TA) procedures. The evaluation will examine the participating teams' codes and approaches in terms of system characterisation (ceptualisation, simplification, mathematical representation and parameterisation), flexibility in handing realistic in-situ geological ditions, capacities in uncertainty source identification and treatment, and computational aspects. The evaluation will be organised around numerical simulations of small-to-moderate scale laboratory tests, specifically defined generic Bench-Mark Tests (BMT), and large-scale in-situ experiments (Test Cases - TC) involving coupled THM, HMC or THMC processes in rock salt and buffer material, so that simulations and evaluations can be ducted within a realistic physical text. This proposed project represents, for the first time, such a coherent and logical effort based on sound scientific principles, and with potentially far-reaching sequences in the field of nuclear waste disposal.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'PROducing Stem Cells for improved Treatment of patients' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The market for stem cells is growing fast as new possibilities for stem cell treatments evolve. Today stem cell treatments are often based on a process where the patient’s own cells are grown for weeks, and thereafter patients are treated with their own stem cells. This process limits a wider use of these treatments, as it is a slow and costly procedure. The key novelty in the PRO-SCT project is that it is the first fully compliant industrially applicable platform capable of large-scale stem cell production from healthy donor adipose tissue, making ready-to-use stem cells available whenever and wherever needed. Cell2Cure has leading competencies in the areas of producing, storing, and distributing stem cells from donors, and clinical and regulatory know-how in the use of cell-based therapies. C2C stem cells will be manufactured in large batches, stored frozen in vials that can be ready for use in a few minutes before treatment. The C2C technology uses state-of-the-art automated closed bioreactor systems with animal component free expansion of allogeneic cells and long-term cryopreservation of ready-to-use vials. Compared to today's stem cell treatment, this allows for scalability and easy distribution - improving availability and reducing both cost and time to treatment. With a strong scientific basis, Cell2Cure has made significant progress in the understanding of donor derived stem cells in the development of treatments for heart failure. Clinical trials have shown that C2C stem cells are safe, usable and have promising clinical effects. The aim of the PRO-SCT project is to develop a strong commercial and operational position for Cell2Cure to move from small scale to large scale capacity and unlock a new global market for adipose tissue derived donor stem cells. To do
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'The impact of collapsing microbubbles on cells' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The aim of the suggested project is to fill the gap between the nicely understood spherical bubble dynamics and the dynamics of bubbles close to in homogeneities, which is far more relevant for medical applications. This research will help to better understand the fundamental mechanics of the interactions between collapsing bubbles and soft materials such as cell walls. We will focus on a new medical application of micro bubbles, namely, their use in therapy, where the bubbles can act as vectors for directed drug delivery and gene transfection into living cells. It has been shown that the permeability of cell walls for large molecules (both drugs and genes) is dramatically increased in the presence of ultrasound micro bubbles. The nature of the mechanism behind this phenomenon is not understood today. One of the candidates for enhancing cell wall permeation are water jets, induced by collapsing bubbles: Electron micrographs of insonated blood cells show conspicuous holes in their walls. If they indeed originate from jet cavitation, this process can be controlled with great accuracy, as ultrasound can be focused onto specific areas and depths in the body: Localized therapy both trough drug delivery and gene transfection becomes possible. To clarify the role of the bubble cavitation in this process and to allow for an optimization, direct observation with an unique ultra-high speed digital camera (128 pictures at 20 million frames per second) is planned.