RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Cohesin Therapeutics. Precision medicine for treating STAG2 mutated cancers'.

assistant: **Concept**

The cohesin gene STAG2 has emerged as a new tumour suppressor frequently mutated in bladder cancer, Ewing sarcoma and acute myeloid leukaemia (AML). Currently, these cancers are treated by cytotoxic therapies and surgery. These treatment plans are limited by unwanted side effects, have not been able to eliminate the high mortality caused by AML, and have not improved over the last few decades. STAG2 mutations are therefore a biomarker for cancer patients with high medical need. We discovered that STAG2 mutated cancer cells are highly vulnerable to the inactivation of another protein, called STAG1, while healthy cells remain unaffected. This highly selective sensitivity of cancer cells towards such a treatment is exceptional and could be exploited for precision medicine. Our long-term aim is therefore to develop STAG1 inhibitors. This precision medicine would greatly decrease side effects and costs, from which patients, doctors, and health insurance companies would benefit. To enable the development of such a STAG1 inhibitor, exploring the innovation potential is essential. For this, several stepping stones need to be reached which we would like to achieve with support of this ERC-PoC grant: (1) optimising our building blocks for a STAG1 inhibitor (2) developing an intellectual property strategy, (3) assessing commercial feasibility and (4) developing a business plan. Altogether, this will result in a proposition package that can be used to present the commercial potential to strategic partners. For this purpose, we have assembled a team that shares the same enthusiasm to achieve our common goal: to develop precision medicine for patients suffering from STAG2 mutated cancer.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Motor Rehabilitation Plasticity Hacking by Engineered stimulation of the brain dUring Sleep-wake cycle' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Brain lesions such as stroke and traumatic brain injury are a major cause of adult-onset disability. Physical therapy, together with robotic aided rehabilitation, is the gold standard for promoting motor recovery. Yet, half of the affected individuals do not fully recover their daily living skills. Hope is provided by advanced neuroprosthetic devices, acting directly at the brain level to promote plasticity, but to date, they still fall short of producing long-lasting brain rewiring. The often neglected but close relationship between sleep, neural plasticity, pathogenesis, and recovery can constitute a key factor to advance treatment. Within this framework, the primary goal of this project is to devise and test a novel neuroprosthetic approach that monitors brain activity and the sleep-wake cycle (SWC) in order to deliver responsive and engineered electrical stimulation (ES) coded in time. To do this, we aim to: 1) investigate SWC architecture in animal models of brain lesion to better understand pathological modifications and to find privileged windows of neural plasticity to deliver therapeutic ES; 2) design, build, and test a closed-loop system capable of recording, processing and detecting SWC stages and electrographic events of interest (e.g. spindles), and also of delivering coordinated ES, including activity-dependent and time-coded stimulation, and; 3) evaluate the designed approach regarding its efficacy in providing long-lasting, robust, and safe motor rehabilitation to injured animals, while also obtaining a proof-of-concept in humans. Highly complementary skills from fellow and host will cooperate to carry in vivo electrophysiology experiments and technological development, while translational pilot experiments will be performed in close collaboration with p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'European Marmoset Research Group EuroConferences: Inter-disciplinary Forum for Discussion and Training in Primate Biological and Biomedical Research' (1998-2002) under Fifth Framework.

assistant: **Objectives**

The European Marmoset Research Group (EMRG), a non-profit organisation, was established in 1994 to facilitate inter-disciplinary communication between institutions - academic and industrial - conducting biological and/or biomedical research with primates. A major goal of the EMRG is to optimise the use of marmosets and tamarins as subjects in a wide range of life science disciplines. The EMRG has published a Handbook of Marmosets and Tamarins in Biological and Biomedical Research (1997), produces a biannual newsletter, and organises annual workshops. The EuroConferences proposed for 2000 and 2002 will bring together expert scientists, veterinarians and technical personnel, on the one hand, and emerging doctoral and postdoctoral scientists, on the other hand, in eight disciplines in the life sciences: behavioural neuroscience, genetics, immunology, laboratory technology/management, pharmacology, reproduction, toxicology, wildlife biology.A tried and tested approach based upon integrative biology will ensure effective cross-disciplinary exchange and will encompass in vitro, ex vivo and in vivo techniques which will facilitate the study of marmosets/tamarins from the molecular level to whole animal studies. Within each discipline, input from experts working with marmosets/tamarins will be considered alongside that from experts working with rodent or Old World primate species. Lecture sessions will include reviews of the merits and limitations of marmosets/tamarins relative to other species, and specific presentations of the very latest empirical findings and methodological advances. In round-table discussions, the interfaces between pertinent combinations of disciplines will be discussed, e.g. behavioural neuroscience and immunology, non-invasive physiological monitoring a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Increasing expertise in micro- and nanoplastics analysis through twinning action' (InPlasTwin).

assistant: **Innovation**

The InPlasTwin main goal is to strengthen the Jožef Stefan Institute (JSI), Slovenia, and the Agricultural University of Athens (AUA), Greece, research and innovation capacity in micro- and nanoplastics (MNPs) analysis through networking, knowledge sharing, and research collaboration with leading European institutions. This will be achieved by fostering strategic partnerships with the Flemish Institute for Technological Research (VITO), Belgium, the Institute of Marine Research (IMR), Norway, and Technical University of Denmark (DTU), renowned for their expertise in MNPs analysis. Access to advanced equipment and training will empower JSI and AUA to excel in MNPs analysis, including extraction, quantification, identification, characterization, and plastic additive analysis. AUA, with its hydroponics and crop cultivation experience, will share its insights while gaining knowledge on MNPs generation from agricultural plastics and its effects on crop quality. Collaboration with the NGO FoodScale Hub (FSH), Serbia, will expand the reach of JSI and AUA's research and reputation and raise awareness about plastic pollution in the agri-food sector. Moreover, twinning activities with VITO, IMR, and DTU will facilitate skills transfer for efficient project management and administration. The project also prioritizes promoting diversity inclusion and ethical practices within JSI, AUA, and FSH, all representing widening countries. The InPlasTwin objectives will be achieved through well-defined twinning activities, including short-term exchanges of both early-stage and senior researchers, organization of training and workshops, thematic scientific meetings, and dissemination of findings within the scientific community, industries, and the public. InPlasTwin aims to advance MNPs resea
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Preparing socio and economic evaluations of future H2 lighthouse projects', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Economic predictions indicate that many national economies are falling into financially difficult times. When this occurs, there is tendency to refocus priories and funds and less emphasis is placed on projects promoting environmental well-being. Prepar-H2 is unique because the partners draw upon five ongoing nationally funded demonstration H2 projects and updating 5th-6th EC framework projects in addition to the national projects, creating many benefits at a very low cost. The thrust behind Prepar-H2 is driven by a study-matrix composed for the Hy-Approval and HyFLEET:CUTE which revealed that social studies carried out in context with hydrogen demonstrations often lacked substantiation and consisted of preset and repetitive questionnaires than revealing dialogues. Often technical and demonstration projects, like some of the national projects referenced here, use vast resources for hardware while neglecting the human interface and cultural variations of both public and private perceptions as well as economic aspects. Integrating lessons learned from these H2 projects, Prepar-H2 will upgrade the social matrix through progressive interviews from a cross-disciplinary approach by involving all stakeholders throughout the entire duration of the project. Applying the same method and having accessibility to others who are involved with other alternative fuels, Prepar-H2 will simultaneously provide an economic comparison between H2, other alternative fuels and conventional fossil fuel. The final outcome will be a systematic social and economic data sets providing grounds for accompanying measures in future hydrogen lighthouse projects. More importantly, findings from Prepar-H2 will not only be applicable to future lighthouse projects but also have the flexibility to be applied
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Adoption and enhancement of open frameworks for converged Audio/Video/TV provision for the home user' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

A/VPack Trial project aims at the adoption and acquisition of technology and expertise in open standards and frameworks for delivery and management of voice and video based services to the end-user. The project first, will adopt and enhance an emerging Video delivery architecture and content handling framework proposed by the DVB forum (MHP) and will combine it with the emerging TASTE framework for time-shifted TV and second, the prevailing Packet Voice protocol (H.323 Voice over IP and Call Handler). The developments will be integrated in an existing system (based on Linux) and evaluated in a rich testbed. The target is to formulate a fully converged Audio/Video delivery platform for residential entertainment. The main proposer business sector is the offering of multifunctional gateway systems.OBJECTIVESIn this project the user and the technology suppliers will cooperate for the adaptation of emerging service frameworks for voice and video based service offering. The frameworks will be integrated over a multifunctional residential gateway of subcontractor In Access. The project:1) will adopt and enhance an emerging open Video delivery architecture and content handling framework proposed by the DVB forum (MHP);2) will combine it with the emerging digital video recording and;3) will adopt the prevailing Packet Voice protocol (H.323 Voice over IP and Call Handler). The target is to formulate a fully converged Audio/Video delivery platform specifically for residential entertainment devices (also called Video Gateways).DESCRIPTION OF WORKThe technical context and main objectives of the project are:1) port TASTE, the Tuxia (Techno Trend's subsidiary) embedded Linux, to the gateway platform;2) to adopt, enhance and port MHP framework for video delivery over the existing gatew
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Direct detection of coherent signals using Fano devices' (2021-2027) under Horizon Europe.

assistant: **Objectives**

This ERC PoC project aims to explore the commercial potential of a new and promising approach for realizing cheap integrated detectors with low energy consumption for use in high-speed interconnects, e.g. within datacenters. The innovative idea behind these new types of devices, denoted Fano Detectors, is based on high-quality research carried out under our ERC AdG “FANO”. Our long-term goal is to establish a start-up company and develop a transceiver product that can directly be sold to datacenters such as Facebook and Google. The main activities in this project focus on maturing the technology, investigating the product feasibility, and developing the business case to establish the foundation for a start-up company. To mature the technology, we will develop a portable demonstration unit (PDU) and test advanced functionalities of the Fano Detector. This PDU will be used to demonstrate our technology at trade fairs and conferences facilitating early engagement with customers. The product feasibility study will enable us to determine whether it is possible to develop a full transceiver product by a tech start-up or not. Based on our determined position in the market from the product feasibility study, we will build the required team and prepare a business plan. The deliverables of the project are a Fano Detector PDU, bill of materials, product specification sheet, and a business plan. A technical risk is the present low-resolution fabrication offered by foundries. We have identified an alternative design to mitigate this. The commercial risk is that it could be too ambitious for a start-up to build a full transceiver product. In this case, alternate routes such as licensing of the technology or partnering with OEMs will be considered. Market reports show that the revenue
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Development and implementation of improved molecular diagnostic tools for evaluation of microbial food hazards and study of the effect of novel food processes on the virulence of foodborne pathogens' in the context of a Sixth Framework call.

assistant: **Objectives**

The guarantee of food safety and quality along the food chain is the principal demand of the European citizen. To establish effective control measures that guarantee food safety and quality 'from farm to table', it is necessary to identify and resolve the problems originating from different microbial hazards, which have been creating continuous food alerts.Consequently, there is a need to understand microbial resistance mechanisms with regard to food production and preservation processes, as well as to develop and optimise strategies for practical and effective implementation of analytical methodologies in the food industry.The objective of this proposal is to tackle fundamental and applied aspects in food safety and quality, being focused on the characterisation and quantification of food hazards via the development and implementation of novel molecular diagnostic strategies. This will allow the identification, characterisation and quantification of microbial food contaminants.In addition, one of the priorities of this research project is the dissection of microbial resistance strategies and their effects on virulence modulation. The genes and metabolic pathways involved in the persistence of microorganisms along the food production process, and in the resistance to emerging food preservation technologies will be determined and characterised.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The making and breaking of ubiquitin chains in cholesterol metabolism' (UNICOM).

assistant: **Concept**

Elevated levels of circulating LDL-cholesterol are a major determinant contributing to atherogenesis and coronary artery disease. Therefore, many studies address the central transcriptional pathways that regulate cholesterol metabolism. However, transcriptional regulation does not allow cells to quickly adapt to the cholesterol fluxes that they encounter. For this, rapid and reversible post-transcriptional modifications are used, in conjunction with transcriptional control. Ubiquitylation - the post-transcriptional conjugation of ubiquitin to proteins – is studied in relation to many cellular processes. Much less is known about the contribution of the ubiquitin-proteasomal-system (UPS) to regulation of lipid metabolism and development of cardiovascular disease.I recently identified the E3-ubiquitin ligase IDOL as a novel post-transcriptional regulator of the LDLR pathway. My lab also recently identified two genes, the E3-ubiquitin ligase MARCH6 and the de-ubiquitylase USP2, for which no role in sterol metabolism was known, as important regulators of cellular cholesterol metabolism. With IDOL, these genes control key nodes of cholesterol synthesis and uptake and represent previously unrecognized mechanisms to control cholesterol homeostasis. To study the contribution of these genes to cholesterol metabolism, we will use state-of-the-art mutant mouse models, in vitro assays, and a unique collection of dyslipidemic patient material. Our goal is to characterize the contribution of these genes to cholesterol homeostasis and to examine their involvement in the development of dyslipidemia and atherosclerosis.Investigating these novel regulatory systems will provide important mechanistic insight into the contribution of the UPS to cholesterol metabolism in health and disease. A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'Nature Based Urban Innovation'.

assistant: **Innovation**

Nature-Based Solutions (NBS) have the potential to respond to climate change, enhance biodiversity and improve environmental quality while contributing to economic regeneration and social well-being. Yet there is a substantial gap between the promise of NBS and their uptake. To unlock the potential of NBS for sustainable urban development, NATURVATION will take a transdisciplinary, internationally comparative approach to: advance assessment approaches (Objective 1) to capture the multiple impacts & values of NBS to deliver a robust evidence base for decision-making; enable innovation (Objective 2) to identify the most promising governance, business/finance and participation models and how to overcome the systemic conditions that currently limit their use to support systemic integration; and generate momentum to realise the potential of NBS through co-design, co-development & co-implementation of new partnerships, knowledge, recommendations, processes and tools required to build capacity, enable replication and foster cultural change (Objective 3). Our transdisciplinary approach working with ‘urban-regional innovation partnerships’ in six different cities and a Task Force of highly respected international organisations working in this arena integrates science, social science and humanities (SSH) and practical expertise and experience to achieve a step-change in the use of NBS for urban sustainability.