RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Bacteriophage receptors in lactic acid bacteria: targets for controlled dairy fermentations'.

assistant: **Objectives**

Food fermentations rely on actively growing lactic acid bacteria added as starter cultures. The fermentation capabilities of lactic acid bacteria can be severely inhibited by bacteriophage (phage) infections. In particular in the dairy field, the constant risk of phage attacks is still the major commercial problem, although identified already in 1935. Today, milk fermentations are continuously scaled up for economic reasons, and short fermentations with more than one filling of the vats per day are common. This increases the opportunities of phages to contaminate and proliferate during the production process of each day. Due to the constant risk of economic losses, control of phage is a major area of concern in handling lactic acid bacteria as starter cultures. Introducing phage resistance genes into phage sensitive LAB to enhance their phage insensitivity has become a very attractive modern approach. Many of the phage resistance mechanisms known so far are active in the LAB cell to prevent phage proliferation (i.e. restriction/modification systems or abortive infection mechanisms). Phage adsorption to the LAB surface is the first critical step, and prevention of this event should also be a powerful approach for phage inhibition. However, the genes specifying phage receptor components and the nature of the phage receptors are less understood. Based on the expertise of the five participants in the field of phage biology and molecular biology of mesophilic and thermophilic LAB used for dairy fermentations, we propose to: 1. identify genes coding for phage receptor components of commonly used LAB (Lactococcus lactis, Streptococcus thermophilus, Lactobacillus delbrueckii subsp. lactis and subsp. bulgaricus) located either in the cell wall or in the cell membrane. Insertion
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'The anti-inflammatory actions of Developmental Endothelial Locus-1 (Del-1)' in the context of a Seventh Framework call.

assistant: **Objectives**

Leukocyte recruitment is an important component of inflammatory and autoimmune disorders and consists of selectin-mediated rolling, the chemokine-induced activation of leukocytes, the integrin-dependent firm adhesion and the subsequent transendothelial migration. LFA-1  is an important leukocyte integrin mediating adhesion by binding to its endothelial counter-receptors ICAM-1 and -2. Whereas many adhesion receptors are known to promote leukocyte recruitment, very little information exists about endogenous inhibitors of the cascade. The lab of the applicant has recently identified the endothelial-derived secreted molecule Developmental Endothelial Locus-1 (Del-1, Edil3) as a potent endogenous inhibitor of the leukocyte adhesion cascade. Del-1 acted as an inhibitor of LFA-1-dependent leukocyte adhesion to the endothelium. Consistently, Del-1-/- mice displayed a pro-inflammatory phenotype with higher leukocyte recruitment in vivo.Recently, we found that Del-1 expression is abundant in the immunoprivileged eye. In the first aim of the present project we plan to study the expression and functional contribution of Del-1 in models of eye inflammation. These studies may identify Del-1 as novel therapeutic approach in eye inflammation.In addition, previous reports have demonstrated that Del-1 is elevated by tissue ischemia or hypoxia. Relative tissue hypoxia is a hallmark of acute inflammation. The mechanisms regulating the hypoxia-related anti-inflammatory response are not well understood. In the second aim of this project we will study whether Del-1 acts to regulate the hypoxia-related anti-inflammatory response. The pro-inflammatory effects of hypoxia in mice can be tested in models of ambient hypoxic exposure (e.g. 8% oxygen for 4-8 h) that induce increased permeability of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Wireless Smart Distributed end System for Aircraft', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

WILDCRAFT proposes the design, development and testing of a proof-of-concept demonstrator of a Wireless Sensor Network (WSN) aimed at applications in the aerospace industry. The continuous pressure on aircraft manufacturers to produce better and more secure aircrafts has led to increasing costs in maintenance and monitoring procedures that are being performed at given time intervals to assess the state of an aircraft. Wireless Sensor Networks (WSN) allows the continuous monitoring of critical variables of the operation of an aircraft, and as such they are able to issue early warning of a possible problem for immediate repairing. WILDCRAFT is paying attention to data fusion techniques needed for obtaining an “abstract sensor” from the measurements taken by a multiplicity of sensors deployed in a specific part in an aircraft. To that end we are going to study the most suitable algorithms to infer, estimate or summarize the state of the physical variable being measured. The designed algorithms will be implemented in a FPGA platform. In WILDCRAFT we are also considering the safety critical nature of any on-board system in an aircraft. The set of safety requirements of the system will be compiled and used for the specification, design and development of the building blocks of the system: sensors, energy harvesting, RF transceiver and microprocessor, and the corresponding levels of software and programmable hardware blocks.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Synthetic Lethal Interactions with nucleophosMin 1' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Less than 25% of patients diagnosed with acute myeloid leukemia (AML) survive longer than 5 years. Current treatment regimen are based on non-specifically acting cytotoxic drugs that cause severe side effects. More effective and more specific, targeted therapies are thus needed. Progress, however, has long been hampered by a lack of understanding of the molecular vulnerabilities of the disease. We here propose to identify and study synthetic lethal interactions with mutations in nucleophosmin 1 (NPM1) in AML. Up to 35% of AML patients bear mutations in NPM1 leading to a localization of this nucleolar protein to the cytoplasm and a characteristic change in gene expression pattern. Moreover, NPM1 mutations appear to be driver events and stable over multiple courses of therapy and relapse. Identifying cellular pathways or proteins that are essential in an NPM1 mutated background but not in NPM1 wild type cells may thus not only contribute to a better understanding of NPM1 biology but also yield entry points for the development of drugs that selectively kill NPM1 mutated AML cells.  We will take an integrated chemical biology approach to first identify small molecules that selectively kill NPM1 mutated over NPM1 wild type cells and then elucidate their mode of action to gain insight into the underlying biology. This project thus uniquely builds on the longstanding experience of the host laboratory and institute in chemical screening, the elucidation of the mode of action of small molecules and in hematological malignancies. The proposal is designed to complement the experienced researchers current knowledge in chemical synthesis, assay development, solid tumor biology and small animal imaging techniques to become a well-rounded chemical biologist with a disease focus on sol
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Social Media: Measuring Effects and Mitigating Downsides' (SOME).

assistant: **Concept**

Social media was initially expected to generate widespread improvements in individual well-being and to have positive externalities in the political domain. Such optimistic expectations soon gave way to a host of concerns about possible negative effects of social media. At the societal level, many started worrying that social media might exacerbate political polarization and propagate misinformation. At the level of individual users, many became concerned that social media might have detrimental effects on mental health, especially among the youth.This research proposal has two major goals: first, to fill critical gaps in our knowledge of the causal effects of social media on users and society; second, to evaluate the effectiveness of interventions aimed at mitigating the downsides of social media. On the political front, I will deploy a novel empirical strategy to investigate the impact of social media on political engagement and conduct a large-scale field experiment to evaluate the effectiveness of an intervention aimed at increasing the quality and reducing the partisanship of the news consumed on social media. On the users front, I will conduct two large-scale field experiments: one aimed at evaluating the impact of an intervention encouraging parents to delay the acquisition of a smartphone for their children on outcomes related to child development; the other aimed at evaluating whether tweaks to the social media environment can mitigate the negative effects of social media on mental health.The overarching goal of this research project is to generate new scientific knowledge on the use and impact of social media, to highlight potential areas of policy intervention, and to evaluate ecologically valid and scalable remedies to the downsides of social media. The uniq
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Development of new ternary silver alloys resistant to sulfidation' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Silver alloys are advanced metals whose demand is based on 2 main pillars: 'electronic industry' and 'jewellery and silverware'. However, a major problem of silver alloys is that they are prone to sulfidation. There is also a strong potential to replace noble metals (gold and palladium) by silver alloys resistant to sulfidation, taking into account that silver cost 30 times less than Gold. In the field of Jewels and silverware, silver tend to darken which is aesthetically unacceptable. Ternary silver alloys have hardly been investigated but showed better resistance to sulfidation and therefore will be studied in this project. Ternary silver alloys will be manufactured by co-sputerring with 3 targets. Developed alloys should fulfill technical specifications from the electric & silverware industry
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Modulated Catalysis by Smart Molecularly Imprinted Polymers' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Molecular imprinting, an important methodology for the straightforward prepared of antibody-like polymers, is recently one of focuses in chemistry because of its importance in catalysis, separation and sensing. Described usually as a ‘from-key-to-lock’ process, the molecular imprinting recognizes and interacts with substrates basing on a specifically complementary framework. The present proposal aims to design ‘smart’ imprinted polymers capable of showing tunable catalysis. Inspired by recent advances in the ‘Smart’ technology, a unique hydrophilic/hydrophobic transition is created within the binding framework. The design of this transition will cause an opening/closing-tunable mechanism within the binding framework, thereby allowing/refusing the substrates in water accessible to the interior. In the opening state, the substrate in water can be freely accessible to the binding framework, thus making possible efficient interaction. Above the transition the blockage of access to the inner largely restricts the diffusion of substrates. In this way, such recognition and catalysis are comparable to an on/off-switchable process, which thus allows one to manipulate the activity by controlling the phase behaviours of prepared materials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Steam Power Generation Turbines' (SAFELUBE).

assistant: **Innovation**

This proposal addresses the cost effective and safe operation of steam and gas turbines. Since 1991 in Europe there have been in excess of 2500 power generation gas turbine related incidents including some 700 fires and 14 explosions. This equates to a risk of fire of 1 in 32 per gas turbine per year. VGB (the international industrial and technical association for power generating companies) state that 94% occur in the area of turbine oil supply. Factory Mutual Corporation data indicates that fire protection measures are only 49% effective. Clearly there is a need, both economically and socially, for more effective fire prevention measures in the power generation industry to improve the security of energy supply, a key objective of the EC. Currently, fire retardant lubricants which could greatly reduce the fire risks are barely used in Europe. The current liberalisation process of several Network Industries in the majority of European countries is opening up new business opportunities for SMEs, not only as users of these industries but also as possible suppliers of new or existing services.In this sense, the liberalisation process has opened up whole new markets in the electricity sector, which has resulted in the start-up of many new small enterprises As one such consortium of SMEs we propose to address the above issues by developing a remote sensing and conditioning system to make cost effective the use of fire retardant phosphate esters as turbine lubricant by extending lubricant life to the life of the turbine and promote its expanded use and create a new market worth 89 million Euro in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Development of an Intelligent Controller for Electro-motors'.

assistant: **Objectives**

Electric motors (EMs) and the systems they drive such as fans, pumps, and circulators are the single largest electrical end‐use. EM are found in industrial and commercial applications such as, pumps, fans, conveyors, lifts, ventilation, compressors, etc. EM’s are designed for a maximum usage and most efficient only during maximum usage. If lower than maximum, the EMs becomes inefficient. Most of the EMs (e.g. for elevator) are not used constantly with maximum load but with a partial load only.The here presented CoMoCo is an intelligent controller for EMs developed by CONTRONICS. Depending on the type of electro-motor and the required capacity, by regulating and controlling the consumption in real-time between 45 to 90 % electric energy can be saved. Our controller measures the electromagnetic field in the EM without using mechanical sensors. The built-in software accurately estimates where the magnetic field will be in the next microsecond. It calculates the minimum and the type of energy required to realize this field and then precisely supplies it, using the data obtained. Switching to energy efficient electro-motors can save Europe up to 202 billion kWh in electricity consumption, equivalent to a reduction of €10 billion per year in operating costs for industry, as well as a reduction of 79 million tonnes of CO2 emissions. CoMoCo was already tested and it demonstrated to be a cutting-edge, energy-efficient, economically accessible and profitable EM controller to reduce the energy consumption by 80% in ventilation systems operated in pig farms. In this proposal, the SME CONTRONICS is applying for funding of a feasibility study for verifying the further technological development as well as economic viability of the CoMoCo intelligent EM control, in diverse industrial a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'reStoring sIGHt wiTh a neuroprosthEsis for the blinD' under Horizon Europe.

assistant: **Concept**

SIGHTED aims to deliver a breakthrough neural implant to restore functional vision in patients who have lost their sight, enabling them to regain autonomy. Building on the ongoing FET-Open NeuraViPeR project (https://www.neuraviper.eu/), which concludes in February 2025, SIGHTED will advance our proof-of-concept prototype (TRL 3) to a fully validated implant ready for human testing (TRL 5). Concurrently, we will prepare for commercial adoption by securing regulatory clearance to initiate a First-in-Human study, refining our business model, developing a go-to-market strategy, and preparing for payer coverage and reimbursement.The neural implant developed in SIGHTED stimulates the lateral geniculate nucleus (LGN), a thalamic nucleus that relays visual information from the retina to the visual cortex. Pioneered by Prof. Dr. Pieter Roelfsema (Institut de la Vision, Sorbonne University, Paris), SIGHTED’s Scientific Coordinator, the implant features a patented ‘Fountain Probe’ capable of distributing electrodes volumetrically within the target structure. With over 1,000 channels—vastly more than the 8-20 channels of existing implants—the Fountain Probe enables precise interventions for conditions like vision and hearing restoration, brain-computer interfacing (BCI), and neuromodulation therapies. Its high resolution, wide field of view, long-term durability, and low surgical risk make it the first solution to meet the critical needs of blind patients.SIGHTED will help us transition from a prototype to a validated implant for clinical testing. Phosphoenix, a Dutch MedTech SME leading the project, plans to implant the first human patient by early 2027 in a First-in-Human study involving five blind patients. To prepare for a 2032 commercial launch, Phosphoenix will strengthen it
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Looking for physics beyond the standard model in unexplored regions at the LHC and flavour experiments'.

assistant: **Concept**

This project is about the search for physics beyond the standard model in contemporary experiments, both the ones at the Large Hadron Collider (LHC) and the ones looking for flavour violating processes. It is a highly interdisciplinary project, since it located at the borders between experimental and theoretical physics. One of the main goals of my proposal is to provide the experimentalists the tools they need in order to search for new physics in their data looking at yet unexplored signatures. As a first step I intend to simulate the expected signals in the framework of a recently proposed supersymmetric model with R-parity violation, using important simulation programs like FeynRules and MadGraph. Then a more general analysis of possible forgotten signatures will be realised, as well as a theoretical investigation following the experimental results.  In parallel to this LHC-oriented program, I propose to tackle the flavour experiments in an original model-independent way, by looking at all the simplest possibilities (1 or 2 new particles, of any kind) able to give a signal in MEG. Then I will calculate the correlations with other indirect experiments and the possibility of testing the corresponding new physics in the LHC. This project is very timely, since these experiments are running now and there is the need of exploiting to the maximum their capability of looking for new physics.