RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'COMBINE-ENGINEER: A software tool for molecular design using protein structure-based quantitative structure activity relationships' (COMBINE-ENGINEER) under Sixth Framework.

assistant: **Objectives**

The structure-based drug design (SBDD) and quantitative structure activity relationships (QSAR) approaches to lead discovery and optimisation are very valuable in drug design. They form the basis of the COMparative BINding Energy (COMBINE) analysis method which is a procedure to derive 3D-QSARs based on the structures of receptor-ligand complexes. COMBINE analysis has been applied to a range of systems including enzyme-inhibitor, enzyme-substrate, protein-protein and protein-DNA complexes. Unlike other 3D-Q SAR methodologies, COMBINE analysis can identify regions in the receptor important for binding specificity. However, the subsequent use of this information for optimising binding by ligand or receptor design is done by manual intervention. Our project aims to develop a software tool, COMBINE-ENGINEER, to automate this design task and embed it with a full iterative COMBINE analysis. It will thus provide an automated procedure for molecular design governed by protein structure based QSARs.Specifically, COMBINE-ENGINEER will integrate:1 COMBINE analysis to compute receptor-based 3D-QSARs;2 Design of ligands and/or proteins to optimise binding as suggested by the COMBINE QSAR model. For proteins, this requires modelling of mutants, performing conformational searches and energetic optimisation. Existent techniques, such as side-chain conformations searching will be incorporated; For ligands, a virtual library of functional groups and a docking algorithm will be used to modify the known ligands;3 Computation of COMBINE scores with the new- modelled complexes;4 Iteration of points 2 and 3 to select the best molecules with optimal binding;5 Additionally, further criteria, such as ADMET prediction and drug-like analysis, will be also considered.The COMBINE-ENGINEER software w
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Reading the genetic history of parchment manuscripts.' to be submitted under Horizon 2020.

assistant: **Abstract**

Medieval texts are a window into the monastic world and an integral part of European written history. Most of our current understanding of the processes of codex construction comes from the careful examination of the clues to manufacture on the object itself, the practice of codicology. Increasingly scholars are interested in the material qualities of the book. How and why were the decisions on the selection of materials made? Recent advances in analytical methods are broadening the reach of codicology in unexpected ways and enabling these questions to be addressed. The SCRIBE project is at the forefront of this burgeoning field of molecular codicology, having developed and implemented an exciting new minimally destructive DNA sampling technique, derived from routine parchment conservation practice. SCRIBE will further implement this method to generate two novel high throughput genomic datasets from parchment manuscripts. Firstly the materiality of the manuscripts will be described by assessing the genetic relationship between the animals used to complete the codices. Secondly SCRIBE will be the first study to combine high throughput metagenomic techniques and novel bioinformatic approaches to a large sample size of documents in multiple archives to look at the microbial fingerprints of parchments, to complement their provenance and curation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'MANAGEMENT AND UNCERTAINTIES OF SEVERE ACCIDENTS' (MUSA).

assistant: **Innovation**

In the current state of maturity of severe accident codes in terms of phenomena addressed and extensive validation conducted, the time has come to foster BEPU,Best Estimate Plus Uncertainties, application in the severe accident (SA) domain, and accident management (AM). The advantages with respect to deterministic analysis are known: avoid adopting conservative assumptions in the model and allow identifying safety margins, quantify likelihood of reaching specific values and,  through the distribution variance provide insights into dominating uncertain parameters.The overall objective of the Management and Uncertainties of Severe Accident (MUSA) project is to assess the capability of SA codes when modelling reactor and SFP (Spent Fuel Pool) accident scenarios of Gen II and III. To do so UQ (Uncertainty Quantification) methods are to be used, with emphasis on the effect of already-set and innovative accident management measures on accident unfolding, particularly those related to ST (Source Term) mitigation. Therefore, ST related Figures Of Merit (FOM) are to be used in the UQ application. The MUSA project proposes an innovative research agenda in order to move  forward the predictive capability of SA analysis codes by combining them with the best available/improved UQ tools and embedding accident management as an intrinsic aspect of SA analyses.MUSA develops through key activities which also describe the main outcomes foreseen from the project: identification and quantification of uncertainty sources in SA analyses; review and adaptation of UQ methods; and testing such methods against reactor and SFP accident analyses, including AM. Given the focus of FOM on source term, the project will identify variables governing ST uncertainties that would be worth investigating furt
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Free Flight - Flight Management System' (3FMS), addressing dissemination and exploitation.

assistant: **Impact**

On one hand, new Air Traffic Management (ATM) concepts are required to face the growing Air Traffic demand because the solution to upgrade the traditional ATC is increasing the number of Air Traffic Controllers and sectors, and has practically reached its limit. On the other hand, the availability of new Communication, Navigation and Surveillance (CNS) technologies provides the basis to move towards advanced ATM concepts such as free-flight. The primary difference between today's route clearance and future free-flight will be the pilot's ability to operate the flight safely without specific route, speed, or altitude clearances. There even may be instances where aircraft separation responsibility will shift from the ground to the cockpit. The deployment of free-flight requires new ATC procedures, advanced airborne FMS and improved airborne situational awareness.In this context the objective of the 3FMS project is to prepare an early functional definition of the European Flight Management System for free-flight operation. The main expected 3FMS achievements are the definition of the Free Flight functions compliant with the new AIRBUS FMS, their evaluation and demonstration in an AIRBUS flight simulator and a list of recommendations for their implementation in the future European ATM system. As a baseline to be reviewed in the course of the project, the onboard tactical flight management functions are aircraft separation, anticipatory terrain avoidance, weather management, and route of preference. The 3FMS technical approach will follow a classical R&D life-cycle: definition, design and prototyping, development, integration, functional validation and operational evaluation. The consortium is composed of 7 partners: three major avionics manufacturers, one major aircraft man
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Arithmetic of K3 Surfaces' will create measurable scientific, societal and economic impact aligned with Sixth Framework.

assistant: **Impact**

Luijk's research is on explicit methods in higher-dimensional arithmetic algebraic geometry, motivated by Diophantine problems. In particular, he works on K3 surfaces, which are of interest to algebraic geometers, number theorists and theoretical physicist s. In his thesis, Luijk solved two explicit open Diophantine problems. He also developed a method to bound the rank of the Neron-Severi group of a K3 surfaces. He has constructed K3 surfaces over the rationales with infinitely many rational points and Neron-Severi rank 1. This answers a question by Swinnerton-Dyer and disposes of an old challenge attributed to Mumford. Recently he has found the first known examples of K3 surfaces with trivial automorphism group.For the project it intended to tackle four problems:Problem 1: Give an algorithm to compute the Neron-Severi group of K3 surfaces.Problem 2: Formulate a suitable Manin-type conjecture for K3 surfaces, linking the distribution of rational points to the Neron-Severi group. Gather theoretical and experimental evidence for this.Problem 3: Give necessary and sufficient criteria for the failure of the Hasse principle to be accounted for by the Brauer-Manin obstruction in terms of the Neron-Severi group.Problem 4: The homogeneous spaces for 2-descent on genus 2 curves have K3 surfaces as quotients.Investigate the implications of our work for the arithmetic of genus 2 curves and their Shafarevich-Tate groups. At Warwick Luijk will be able to draw on the expertise of Reid in algebraic geometry, Kresch in abstract arithmetic geometry and Siksek in explicit arithmetic geometry and Diophantine equations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'The Strasbourg Court, democracy and the human rights of individuals and communities: patterns of litigation, state implementation and domestic reform' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

JURISTRAS studies the relationship between courts and politics, between judicial review of human rights at the supranational level and domestic politics and policies in Europe. Specifically it comparatively explores processes human rights litigation and state implementation of European Court of Human Rights judgments, as well as the effects of the latter in national legislative reform and policy making in a number of EU member states and Associate Candidate States. In response to Court judgments national authorities may seek to evade or contain compliance, but they may also undertake broader reforms to pre-empt recurring infringements of human rights provisions.JURISTRAS shall examine under what conditions Strasbourg Court judgments that find state authorities to have breached Convention provisions promote broader domestic reform or policy-change and expand justice for individuals and communities. We shall explore the hypothesis that patterns of state compliance and national implementation of Court judgments centrally depend on and are mediated by domestic processes of societal mobilization, public support and elite learning. We specifically focus on the Court's growing jurisprudence pertaining to the civil rights of individuals and communities, and their participation in the public sphere in a democratic setting.Such case law has primarily grown out of specific categories of cases brought to the European Court of Human Rights, in which individuals claim a violation of their right to privacy and family life, religious freedom and conscience, freedom of expression, assembly and association, and discriminatory treatment. In the course of our research, we shall identify best practices concerning the establishment or improvement of national and EU-level mechanisms for addre
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Energy Futures of the High North: Assessing Intermediary Expertise and New Valuation Practices that Guide Arctic Hydrocarbon Development' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

I will undertake research assessing the role of intermediaries (consultants) in creating Arctic energy futures and utilize a training plan of Professor Markku Kivinen, Director, Aleksanteri Institute, U Helsinki, in order to transition into a globally recognized leader of Cultures of Expertise frameworks for scholars involved in the anthropologies of finance, futurity and expertise, linked to Science and Technology Studies-related genealogies. I want to improve the state of theory and knowledge in relation to how intermediaries engage in valuation practices that drive the location and content of pivotal conversations on Arctic oil and gas extraction. Two patterns of development will be addressed: the increasing visibility of Arctic energy futures as detailed expectations that represent strategic resources for attracting attention from (financial) sponsors to stimulate agenda-setting processes; and, the rise of intermediaries suggesting a trend towards greater control over access to Arctic knowledge that is privatized via commodification. Research objectives include building a conceptual terminology and typology of the kinds of assessments that consultants produce, further developing alignments at the intersection of proprietary practice and multidisciplinary analysis. I will combine data collection at two consulting firms and at six key networking events with a training secondment at Regional Council of Lapland in order to pilot industry and policy relevance. My US National Science Foundation research will create EU knowledge transfers for the systematized study of intermediary experts and Arctic energy futures through graduate supervision and symposiums leading to four peer-reviewed journal articles and a co-edited volume. Supervised training on science management invo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Treatment of reperfusion injury using a mitochondrial targeted approach: towards a better understanding of the disease' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Current interventional treatment of acute myocardial infarction (AMI) focused on re-establishing cardiac reperfusion has significantly improved clinical outcome by reducing infarct size and mortality due to cardiac ischemia.It is now recognized that events triggered at reperfusion also result in cell death and may account for as much as 50% of the infarct volume, this being termed ischemia-reperfusion injury (IRI). Mitochondrial permeability transition pore (mPTP) opening appears to be a responsible for IRI and a recent small clinical trial with cyclosporine A shows that it is a feasible target for the development of new therapies to treat it. Since total infarct size is a major determinant of a patients risk to develop heart failure, treating IRI is expected to further reduce morbidity, mortality and the need for regenerative medicine following cardiac ischemia. By harnessing a multi-disciplinary consortium of clinical and basic scientists along with four SMEs, MitoCare brings state-of-the art expertise together to 1) better understand IRI pathophysiology and factors directly or indirectly influencing patient’s recovery or response to treatment; 2) investigate the translational usefulness of preclinical models; and 3) compare selected treatments. These objectives will be reached through the following work plan: A) a medium-scale phase II clinical study will evaluate the efficacy of a novel complementary therapy to PCI, the new mPTP modulator TRO40303, while at the same time 1) perform extensive sampling from subjects in the study for analysis of standard and emerging biomarkers; 2) identify confounding factors influencing patients’ outcomes. B) Parallel investigations in preclinical in vitro and in vivo AMI models. C) Statistical analysis of data from clinical and prec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Laser equipment ASsessment for High impAct innovation in the manufactuRing European industry' (LASHARE) targeting Seventh Framework.

assistant: **Abstract**

LASHARE will develop a robust assessment framework for innovative laser equipment paving the way for new manufacturing applications. It will carry out a large number of assessment experiments for a variety of laser equipment targeting strategic manufacturing areas for Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Exploring the hidden life of African trypanosomes: parasite fat tropism and implications for disease' (FatTryp).

assistant: **Concept**

Background: The study of protozoan pathogens has been extensively explored often motivated to find suitable targets for new intervention strategies. However these studies have been mostly limited to those life-cycle stages that can be cultivated in vitro. Using a mouse model of African trypanosomiasis, we have recently discovered that the adipose tissue (fat) is a major reservoir for the extracellular protozoan Trypanosoma brucei and that, within this environment, parasites become phenotypically different from those in the blood. Our study exposed novel biology of the T. brucei life cycle, yet it remains unknown how parasites adapt to the fat and how parasite fat tropism affects disease.Our first aim is to determine the molecular and cellular mechanisms underlying T. brucei fat tropism. We will perform a genetic screen in mice to identify key parasite genes required for establishing and maintaining chronic infection in the fat. Together with the information of the transcriptome and proteome, we will identify the mechanistic steps underlying parasite tissue-adaptation.Our second aim is to identify the consequences of T. brucei fat tropism for the host and the importance for disease. We will first investigate if parasites can egress from the fat. We will also determine if parasites induce lipid breakdown in the host, leading to loss of fat mass. Finally, we will measure the impact of fat tropism in general traits of disease, including host survival and transmission potential.Impact: This project represents a completely novel research avenue built on recent work from my laboratory. By uncovering fundamental aspects of the biology of T. brucei, we will also improve the understanding of clinically relevant features of African trypanosomiasis, including relapses and weight lo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Switching and Topology of Unconventional Magnetic Materials' under Horizon Europe.

assistant: **Concept**

The continuous increase in global energy demands – whether to power the electrical grid, store information in the cloud or train cutting-edge artificial intelligence – requires more efficient means to generate, store and use energy. In that regard, spintronics aims to improve areas in microelectronics where energy is lost during the processing, manipulation or storage of information. The fundamental goal of STUMM (Switching and Topology of Unconventional Magnetic Materials) is to theoretically describe new ways to store and process information through understanding the transport and topological properties of novel unconventional magnetic materials, such as materials described by spin-group symmetries, including altermagnets. Altermagnets are materials that share properties from both ferromagnets and antiferromagnets, and are excellent candidates for next-generation magnetic memories. STUMM will use state-of-the-art quantum transport methods to investigate unique and effective ways to control and switch magnetic order in altermagnets. STUMM will also produce an open-source package to automatically generate theoretical models of altermagnets so the research community can focus on their physics instead of their modeling. Finally, STUMM will explore the stability of topological states, which are able to carry information without dissipation, protected by spin-group symmetries. Thus, STUMM will provide experimental guidance and expectations about measuring such novel topological states. The applicant will gain expertise in powerful computational techniques, learn code development practices and solve important open questions in the field of unconventional magnetism. Due to the international collaborations and broad network of Prof. Roche and ICN2, the applicant will increase