RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DeepZyme: Learning Deep Representations of Enzymes for Predicting Catalytically-Beneficial Mutations' (DeepZyme).

assistant: **Innovation**

During the course of evolution nature has created and optimized extraordinary protein catalysts, named enzymes, that are fundamental in all reigns of life. Enzymes facilitate complex chemical reactions at physiological conditions, accelerating their rates by several orders of magnitude and being highly selective over alternative –undesired– chemical transformations. Understanding how enzymes work and how to engineer their functions is essential for many disciplines, with applications ranging from medical therapies to biotechnological devices. The main challenge towards the rational control of enzymes is that given their complexity, it is not trivial to predict modifications –known as mutations– that are beneficial for their activity. The DeepZyme project aims to develop a model for the prediction of such modifications, taking advantage of revolutionary techniques in the field of deep learning. We propose to obtain condensed “representations” of enzymes by leveraging their sequence, structure and catalytic information. These representations can be suitably designed to describe enzymatic information that is available in nature, and learn how enzymes have been tuned by selection pressures along evolution. Navigating in the space of enzyme representations will allow us to finely tune their properties, and thereby guide a rational design process. Our model will be used together with other state-of-the-art techniques (including molecular dynamics, Markov state models and quantum mechanics / molecular mechanics) to generate from scratch an enzyme able to catalyze chemical reactions along the synthesis of drug-like molecules.


**Keywords:** engineering of enzymes, deep learning, all-atom molecular dynamics, Markov state models, quantum mechanics, molecular mechanics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Integrating cognition, emotion and autonomy' (ICEA).

assistant: **Innovation**

The ICEA project will develop the first cognitive systems architecture integrating cognition, emotion and autonomy (bioregulation and self-maintenance), based on the architecture and physiology of the mammalian brain. A key hypothesis is that emotional and autonomic mechanisms play a critical role in structuring the high-level thought processes of living cognitive systems like ourselves. The robots developed will perceive and act in the real world, learn from that interaction developing situated knowledge (representations of their environments in spatial, emotional and behavioural terms), and use this knowledge in anticipation, planning and decision-making.The brain and behaviour of the rat will be an important starting point because of the large scientific literature available for this species. Rat cognition will be studied and emulated both through an ambitious program of empirical studies in real animals and through computational modelling, at different levels of abstraction, on several, real and simulated, robot platforms. The project will develop two central, integrated platforms, rat-like in appearance, perceptual, and behavioural capacities. First, a robot, ICEAbot, equipped with multimodal sensory systems will serve as a real-world testbed and demonstrator of the cognitive capacities derived from models of rat biology.Second, a 3-D robot simulator, ICEAsim, based on the physical ICEAbot, but also offering richer opportunities for experimentation, will demonstrate the potential of the ICEA architecture to go beyond the rat model and support cognitive capacities such as abstraction, feelings, imagination, and planning. This second platform will be made freely available to the research community as a potential standard research tool.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'HIGHLY FLEXIBLE, HIGHLY THERMAL CONDUCTIING CERAMIC NANOFIBER COMPOSITES FOR PRINTED CIRCUIT BOARD APPLICATIONS'.

assistant: **Innovation**

FLEXIRAMICS® is light and flexible like paper but 100% ceramic and has a low cost for a ceramic; it is calculated that Flexiramics® will costs 30€/m2 at production level whereas ceramic sheets costs tens of hundreds of euros. Its unique properties open new doors for the development of next generation products limited by traditionally available materials.Flexiramics® has numerous benefits over current ceramics, in particular that it behaves like paper and can be bent and shaped into any position, and that it is not brittle. Therefore it can be used in many harsh environments without the limitations of currently available to ceramics and also providing unique thermal, electrical, catalytic and filtering characteristics.Flexiramics® has been developed as a novel functional 100% ceramic nanofibers mat. It consists of a non-woven matrix of ceramic nanofibers, which enhances its flexibility. Furthermore, when combined with a polymer (up to 50% ceramic loading), we obtain a High Performance Film where plastic properties are improved.Will Flexiramics Change Circuit Boards Forever? Current flex PCBs are fabricated on top of polymer substrates, which have a very low thermal conductivity. Chips and electronic components generate heat; when a substrate with low thermal conductivity is used, the chip get hotter, lose efficiency and malfunction. Flexiramics® PCBs can achieve a significant improvement in thermal conductivity, which would be beneficial for power electronics and telecommunications. We strategically chose to work on the polymer-ceramic composite market as it is a fast-growing market and Flexiramics® can break the limitation of the ceramic loading. We choose to make Flexiramics®-PI due to the large usage of this polymer in the fields of flexible displays and PCBs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strong Microwave Erbium Coupling', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Electronic and nuclear spins in solids have remarkable coherence properties which makes them ideal qubit candidates for future quantum computers. However, microwave detection and coupling of individual spins remains an outstanding challenge, and this is the main obstacle to their use for quantum computing. The rare earth element erbium (Er) is a very promising candidate for single-spin detection due to its exceedingly large electronic ground-state moment (J=15/2). Furthermore, Er has recently demonstrated 1.3 second hyperfine spin coherence (https://arxiv.org/abs/1611.0431), thus joining a very short list of solid state defects with coherence times of over a second. The Strong Microwave Erbium Coupling (SMERC) proposal aims to use superconducting circuits consisting of resonators and Josephson qubits to detect and couple individual Er spins in crystalline matrices.The superconducting circuits will be designed so as to enhance their magnetic coupling to the individual Er spins. In particular, nanoscale constrictions will be used to concentrate the microwave magnetic field at the Er ion location. This will result in Er-microwave photon coupling constants sufficient to detect a single Er spin within less than a millisecond integration time with microwave signals.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Photon and Neutron Open Science Cloud' (PaNOSC) under Horizon 2020.

assistant: **Objectives**

PaNOSC will build on top of the existing local meta-data catalogues and data repositories to provide federated services for making data easily Findable, Accessible, Interoperable, and Re-usable (FAIR).  Extracting the scientific value of the experimental data produced in our RIs is not always an easy task. The raw data tends to be larger and larger and quite often required special skills for being correctly exploited. PaNOSC will develop and provide data analysis services to overcome these difficulties. The services will include notebook (Jupyter based), remote desktop applications and containers or VMs. These services will be provided locally by the RIs for their users (especially when they are on site or when the volume of data is too huge to be exported), the same services should also be available on the EOSC for general use. The data analysis services will offer in a single user experience the data, the software, the IT capacity and the necessary scientific support.  All these services should be fully integrated into the EOSC catalogue, in terms of discovery, accessibility, and user authentication/authorisation, SLA, accounting etc. The PaNOSC cluster will also help introduce a new data culture to the user community – via training at each site and workshops on scientific data management and publishing practices. Best practices in data stewardship will be shared with other laboratories within the PaN community and other clusters. Experiences, trials and results will be shared openly via publications and meetings. The positive experience of implementing an Open Data policy and connecting data and services to the EOSC will help convince other PaN institutes still struggling with adopting the FAIR principles.


**Keywords:** EOSC photon neutron FAIR open data metadata c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Surplus value hybrid (SUVA)' (SUVA).

assistant: **Innovation**

The strategic aim of this project is the development of a marketable and cost- effective hybrid power train by a common effort between the concerned partners, which shall lead to significant reductions in fuel consumption and therefore higher energy efficiency, will be fully accepted by the customer by its performance, reliability and hybrid-specific surplus values, and will maintain the competitiveness and attractiveness of the European car-manufactures by new product innovations. The output of this project shall lead to an effective and serious contribution for the future need in new transport means and concepts. Therefore this project is clearly focused on the development of a marketable hybrid power train in a time period of 3 years, validated by three demonstrator cars of different classes.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a cooling process for heating components in electronic & other systems by a new heat absorption technology in porous environment' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

The objective of the research is to conceive a new cooling system in order to cool heating components in electronics, in porous environment, replacing piezo electric effects or fans which are actually used. To do so, the principle is that an appropriated liquid is stocked in a special porous component implemented at a given distance nearby the heating components which must be cooled. This liquid vaporises at the given temperature and its vapour has a calculated capacity of heat absorption and, for a space it cools the heating components in a given time. Then with even a small decrease of temperature this vapour returns to its liquid form and is absorbed again and continuously by the porous component (capillarity). The potential business of the concerned new performant cooling system is directly linked to this tremendous market of electronics included in end-user products, like cars or other household goods, for instance . Considering both economical and technological aspects, developing such technologies and prototypes with tests and experiments is too much complicate and risky without the contribution of major RTDs . The here after SMEs French and English specialist in heat absorption and isolation of electrical or electronic systems have complementary experiences and know how. Envisaging the here project, especially considering the R&D means required to achieve it correctly they have concluded they have not enough R&D means to go alone into without getting an unreasonable risk. So they have decided to set up a cooperative R&D program and to ask the contribution of EC., RTDs and eventually of other concerned proposers
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Component information representation European project' (CIREP), addressing dissemination and exploitation.

assistant: **Impact**

CIREP addresses European industry's crucial need for the availability of reliable and standardised digital representations of components which can be used in an integrated design and manufacturing environment and which will facilitate exchange of manufacturing information, both within and between enterprises, through the complete life cycle of products in which such components are used.The benefits for European industry will be significant improvements in marketing position for component manufacturers by providing their customers with easily accessible and usable information of quality in forms which will result in significant cost saving for component users.The work to be undertaken has the following main aims :- to develop and validate a methodology for defining and modelling the functional and physical characteristics of components, building a formal data model using the EXPRESS language to control the completeness and consistency of component specifications through the complete operational chain from definition to storage, distribution and use.- building on an existing component database, to create a prototype of standardised component information system (CIS) which implements the above methodology and demonstrates the feasibility of the approach.- to implement network services for electronic trading of component libraries and to investigate and propose solutions for the problems raised by Intellectual Property Rights (IPR), copyright and fees redistribution which will arise in such an electronic trading environment.- building on an existing system, to develop a general Component Information Handling System (CIHS) which will allow information from standardised libraries of component information to be integrated into end users' own design and manufacturing environmen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'DNA-sensing by AIM2 in activated B cells: novel targets to improve allogeneic haematopoietic stem cell transplantation' (DABAT), addressing dissemination and exploitation.

assistant: **Impact**

A recent paradigm shift is that B cells are pivotal in chronic graft-versus-host-disease (cGVHD), which is the most relevant cause of late non-relapse morbidity and mortality after allogeneic haematopoietic stem cell transplantation. DABAT’s project hypothesis is that 1) DNA-sensing by AIM2 supports cGVHD pathological B cells through autocrine regulations and that 2) their DNase1L3 expression modulates DNA-sensing by AIM2. Doctor Sarantopoulos (Duke University, US, supervisor for the outgoing phase) recently performed a single cell RNA-Sequencing experiment showing that AIM2 is upregulated in cGVHD patient B cells. Upon DNA binding, the AIM2 protein induces AIM2 inflammasome formation that triggers pro-inflammatory cytokines secretion. The survival and function of pathological B cells in cGVHD seem to be based on similar mechanisms to those of marginal zone (MZ) B cells. Doctor Sisirak (Bordeaux University, France, supervisor for the incoming phase) showed that DNase1L3, a major enzyme regulating extracellular DNA exposure, could play a pivotal role in MZ B cells development. The researcher will conduct the DABAT project under the supervision of these two internationally recognized experts in cGVHD B cells and DNase1L3. He will study AIM2 and DNase1L3 in human B cells and in mouse models. This fellowship will provide him with advanced technical training in B cell studies, flow cytometry, transcriptomic, histopathology and animal handling. He could identify intrinsic molecular programs underpinning B cell pathobiology, so that agents targeting B cell can be developed to treat cGVHD. He will be the main spokesperson of the project to a large audience. This fellowship will be a crucial step to extend his knowledge, to develop his communication, management and leadership sk
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Micro-foundations of Entrepreneurial Dynamics' under Seventh Framework.

assistant: **Concept**

Entrepreneurship is recognized as important for growth. European policies to facilitate entrepreneurship, however, have been less successful than expected and the EU continues to lag other advanced economies. This may reflect an incomplete understanding of the underlying processes affecting firm creation. The incoming fellow will enhance the potential for identifying economic and social factors associated with the creation and survival of new firms. While the primary context will be the UK, elements of the project will involve other EU countries. The focus--the micro foundations of entrepreneurial development--will be on the interaction of entrepreneurial characteristics, ambitions, business strategies, and environmental factors, including policies, institutions and social context.Aston Business School (ABS) excels in economic aspects of entrepreneurship research, and will benefit from synergies drawing upon the incoming fellow’s background in sociology and management research. ABS has been a key player in the major international entrepreneurial research programme, the Global Entrepreneurship Monitor (GEM). The incoming fellow was not only the founding principle investigator of GEM, but also had a central role in developing longitudinal studies of the entrepreneurial process; Panel Studies of Entrepreneurial Dynamics (PSED) have been implemented in nine countries.The methodological expertise of the incoming fellow will facilitate expanding the GEM programme with a complementary longitudinal study, a UK–PSED. This will provide more precise information about factors preceding and accompanying the birth and growth of firms and will form the basis for improved theoretical analysis and fact-based policy recommendations around four specific research issues: the role of local
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Generative Spatial Synthesis of Sound and Music' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Machine learning is particularly well-suited to the processing of ill-defined problems, where complexity rules out direct solutions; it is therefore of paramount importance in the field of music creation, where compositional knowledge is far from explicit. Until now, the generation of sound spaces has often been neglected in the application of AI to music and sound, whereas 3D spatial audio is undergoing significant industrial development.The G3S research project, designed by and for musicians and sound creators, will take sound creation to a new level by enabling the generative synthesis of sound spaces in a context of man-machine interaction. This research will challenge the very notion of space in music and revolutionize practices: we will propose new ways of creating, modeling and analyzing sound by natively integrating its spatial dimension. G3S has four research objectives: 1) to design a unified operative representation of spatial synthesis 2) to propose a thesaurus and quantitative measures to describe the spatiality of sound 3) to generate sound spaces from machine learning 4) to design interfaces for exploring spatial synthesis through listening, semantic or functional description.We will form an international research network on the subject to consider what already exists and test our new proposals; we will develop open-source environments for each of the four objectives; and we will generate musical and sound creations using the project's results. There will be a wide range of uses, from artistic creation (installations, concerts) to video games and applications on phones or in virtual reality. Finally, the developments achieved will be integrated into the workflow of sound designers, and compatible with spatial audio standards.


**Keywords:** Computer Musi