RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modelling of non-native fish species responses to climate change' (2007-2013) targeting Seventh Framework.

assistant: **Abstract**

Non-native species introductions are a major concern in Europe and globally, threatening biodiversity, ecosystem function and global economies; this will be exacerbated with climate change. Current climate change models for Europe and the UK predict: progressively warmer, wetter winters; warmer, dryer summers; an increase in extreme river flows. This is likely to increase the risk of non-native species reproductive potential and dispersal, which are key factors in establishment success. Using pumpkinseed Lepomis gibbosus in ambient and warm-water conditions as a case study, the Fellowship aims to: 1) Assess pumpkinseed growth and reproductive traits in nature (using methods currently employed for the species); 2) Acquire estimates of spawning event frequency in nature and in the lab to assess reproductive output (direct observation in semi-natural ponds via a novel telemetry array system, and in lab experiments, plus egg size distribution analysis on wild caught fish); 3) Determine pumpkinseed dispersal rates from floodplain water bodies into receiving streams (using drift nets to estimate propagule pressure); and 4) Develop (or improve existing) models of pumpkinseed reproductive output and dispersal (using relationships between juvenile growth and mean age at maturity, gravity models to assess the dispersal process, and GIS software to produce risk maps to aid in identifying areas at risk of biological invasion).  The proposed fellowship is particularly novel in aiming to two important and timely questions relevant to the assessment of risks posed by non-native species in general, and of pumpkinseed in particular: 1) Will climate warming increase the risk of non-native fish establishing self-sustaining populations? 2) Will increased variability in precipitation and ri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The effect of pressure and chemical substitution on the Kitaev Heisenberg system alpha-RuCl3' (PRESS-CHESS-KHS), addressing dissemination and exploitation.

assistant: **Impact**

The Kitaev model on a honeycomb lattice has caused an abiding fascination due to its quantum spin liquid ground state, which is relevant to register information in matter and specifically for topological quantum computation. Here, alpha-RuCl3 is believed to be the prime material to-date to harbor such a quantum spin liquid phase. Recent studies from 2016 showed that a magnetic field can induce the highly desired quantum spin liquid state. As a new route towards the realization of this state in alpha-RuCl3, this research project will concentrate on tuning the magnetic properties by the application of hydrostatic pressure and chemical substitution. Their influence on the Kitaev-like interaction, the magnetic ground state, and the field-induced quantum spin liquid state will be studied by magnetization and thermodynamic techniques.During the time of his PhD, the applicant acquired a strong knowledge on magnetism and experimental skills in high-pressure and low-temperature measurements. This makes the applicant perfectly adapted for this research project, which will be conducted under unique conditions at the host institution. At the IFW Dresden high-quality single crystals and world-class experimental facilities (such as a unique pressure cell) are available. Via the solid experience of the applicant in high-pressure physics, this pressure cell will be improved to an even higher accuracy in the research project.The applicant will follow trainings to study research integrity, develop his own leadership, construct this career development plan and learn German to obtain a clear visibility to continue an excellent career in academic research. He will disseminate his results among the scientific community through publications in high-ranking scientific journals, and participati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Combining Stem Cells and Biomaterials for Brain Repair - Unlocking the Potential of the Existing Brain Research through Innovative In Vivo Molecular Imaging'.

assistant: **Concept**

The main aim of GlowBrain is to unlock the existing research potential of University of Zagreb School of Medicine and respond to an emerging need for combined stem cells and biomaterials applications in brain repair. The already existing platform for mouse brain research is currently involved in research of molecular mechanisms underlying brain damage and repair. It includes the expertise and equipment to assess the brain at system (behavioral analysis, neuroanatomy and neurodevelopment), cellular (microscopy and in vitro techniques) and molecular levels (molecular biology techniques). Through analysis of transgenic mouse models this is combined with competence to introduce the experimental brain damage in form of ischemic injury (MCAO), seizures or stereotaxic lesions.Here we propose an innovative upgrade of existing facilities to enable simultaneous application of stem cells and biomaterials with the goal to enhance beneficial effects of stem cell therapy. By extending the platform with components for in vivo molecular imaging using bioluminescence and magnetic resonance, the insight in the underlying molecular mechanisms of stem cells and biomaterials applications would be achieved. Innovative multimodal combination of bioluminescent imaging (BLI) and magnetic resonance imaging (MRI) of the upgraded platform would enable to follow in real time, in living animals the molecular events in the mouse brain and fine tune consequences and efficiency of stem cell therapies. Together with already existing excellence in neuroscience research, the upgrade would result in a novel and complementary asset to leading European capacities.Unlocking the research potential of University of Zagreb by assembling a unique platform at European Research Area level would have a high impact f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Surgical optogenetic bioprinting of engineered cardiac muscle' (LIGHTHEART), addressing dissemination and exploitation.

assistant: **Impact**

Heart failure remains a leading cause of mortality worldwide taking an estimate of 16 million lives each year. Cardiac tissue engineering solutions that can improve the quality of life of those with advanced heart disease have proved challenging so far. Bioprinting is an exciting technology that holds promise to fabricate tissues and organs. Lab-grown engineered cardiac muscle requires at least four weeks to maturate in a bioreactor. In LIGHTHEART, an off-the-shelf solution will be developed for treating injured myocardium in vivo. An unconventional combination of bioprinting and optogenetics will be used to surgically fabricate engineered cardiac muscle directly at the patient’s heart. A surgical bioprinting tool will be constructed to achieve vascularization and cellular architectures as that observed in native cardiac muscle. Induced pluripotent stem cell-derived cardiac cells will be the basis of the bioinspired biomaterial-free ink that will be printed. Optogenetic expression of different light-sensitive proteins at the cell surfaces will be the sole trigger of cellular assembly, thus omitting the need to embed cells in hydrogels or printing in a supporting bath. Surgical optogenetic bioprinting will be first tested ex vivo using a silicone human phantom with a mimicking beating heart, and later in vivo in a large animal model in accordance with the 3R principles. LIGHTHEART opens up new horizons in the way heart failure can be clinically treated and brings hope to patients who are desperately waiting for a heart transplantation. The disruptive nature of LIGHTHEART will unite engineers, surgeons and scientists to change the future of transplantation medicine with modular bottom-up technologies that allow for in vivo tissue and organ restoration or replacement direc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Stardust to asteroids: Unravelling the formation and earliest evolution of a habitable solar system' under Seventh Framework.

assistant: **Concept**

As far as we know, our solar system is unique. It could, in principle, be the only planetary system in the Universe to harbor intelligent life or, indeed, life at all. As such, attempting to reconstruct its history is one of the most fundamental pursuits in the natural sciences. Whereas astronomical observations of star- forming regions provide a framework for understanding the formation of low-mass stars and the early evolution of planetary systems in general, direct information about the earliest solar system can only come from primitive meteorites and their components and some differentiated meteorites that record the birth of the solar system. The main objective of this proposal is to investigate the timescales and processes – including the role of supernovas – leading to the formation of the solar system by measurement of isotopic variations in meteorites. To achieve our objectives, we will integrate long-lived and short-lived radioisotope chronometers with the presence/absence of nucleosynthetic anomalies in various meteorites and meteoritic components. Our isotopic measurements will be obtained using state-of-the-art technologies such as second-generation mass spectrometers housed in laboratories directed by the PI and fully dedicated to cosmochemistry. This will allow us to: 1) define the mechanism and timescale for the collapse of the protosolar molecular cloud and emergence of the protoplanetary disk, 2) constrain the source and locale of chondrule-forming event(s) as well as the nature of the mechanism(s) required to transport chondrules to the accretion regions of chondrites, and 3) provide robust estimates of the timing and mechanism of asteroidal differentiation. We aim to understand how the variable initial conditions imposed by the range of possible stel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Continuous, highly precise, metal-free polymerisation of PLA using alternative energies for reactive extrusion' in the context of a Seventh Framework call.

assistant: **Objectives**

The demand for biobased polymers is growing fast. According to the current state of the art, metal-containing catalysts are needed to improve the polymerisation rate of lactones, posing a hazard to health and the environment. InnoREX will develop a novel reactor concept using alternative energies for the continuous, highly precise, metal-free polymerisation of PLA.In InnoREX, metal-containing catalysts will be replaced by organic catalysts. These have been shown to efficiently control the polymerisation of lactide, but their activity must still be improved to meet industrial standards. This will be achieved by the low-intensity but highly-targeted application of alternative energies (microwaves, ultrasound, laser light). These energies increase catalyst activity and enable precise control of the reaction by exciting only small parts of the reaction mixture without response time.To ensure short market entry times commercially well-established co-rotating twin screw extruders will be used as reaction vessels. The reason commercial polymerisations are not yet carried out in twin screw extruders is the short residence time and the static energy input of the extruder, which allows no dynamic control of the reaction. Again, these obstacles will be overcome in InnoREX. The project will utilise the rapid response time of microwaves, ultrasound and laser light to achieve a precisely-controlled and efficient continuous polymerisation of high molecular weight PLA in a twin screw extruder. Additionally, significant energy savings will be achieved by combining polymerisation, compounding and shaping in one production step.For a deepened scientific and engineering understanding of the reaction, the effect of the alternative energies on the reaction kinetics and the potential applicat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Tailored Lightweight Sandwich Composites with Multifunctional Properties and Good Designability: From Molecule-design to Structure-properties Relationship' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

With the increasing demand for energy saving and emission reduction in the transportation industry, the study on lightweight sandwich composites (LSCs) has attracted much attention during the past two decades. However, current LSCs were strongly limited by the properties of lightweight core materials. In this context, a two-step process was designed to prepare fibre reinforced foaming unsaturated polyester composite (FR-FUP) as a novel lightweight core of sandwich composites. The pre-foaming sheet is prepared as the basic component of FUP composites, which make it possible to form the foam core material in situ when preparing the sandwich composites. In this project, aiming at solving some key scientific problems of FR-FUP composite and providing theorical base to the development of new generation LSCs. Based on the targeted molecular design and synthesis of UP polymer matrix, and the modified pre-foaming sheets, the fellow will focus on the advanced FR-FUP composites with high mechanical properties, high flame retardant performance and good designability. The main objectives include: (1) to find an optimal polymer matrix for the two-step molding process of FR-FUP composites by click polymerization; (2) to establish structure-property relationship between tailored UP resin and FR-FUP composites; (3) to prepare multifunctional lightweight composite and expand its application in transportation industry. This proposal presents an interdisciplinary and innovative approach with great significance. The original ideas will bring us bran-new to design and prepare LSCs.


**Keywords:** Sandwich Composites,  Lightweight
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Exploring Tipping Points and Their Impacts Using Earth System Models' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

TipESM brings together scientists from a range of disciplines to deliver a step change in our understanding of climate tipping points in the Earth system, including their impact on ecosystems and society, combined with a set of early warning indicators and safe future emission pathways that minimise the risk of exceeding such tipping points. TipESM assembles the latest Earth System Models (ESMs), including recent improvements to key processes: ice sheets, vegetation and land use, permafrost, marine and terrestrial biogeochemistry. In cooperation with the WCRP/Future-Earth project TIPMIP, TipESM will organise an international collaboration to design and realise a common ESM experiment protocol that will facilitate analysis of the likelihood of occurrence, and potential reversibility, of tipping elements at different levels and duration of global warming. These experiments, will be combined with more project-specific ESM experiments, designed to investigate interactions and feedbacks across the Earth system. Based on the TipESM experiments, existing simulations and observations, we will investigate tipping points, their driving processes, potential early warning signals and cascading effects across the climate, ecosystems and society. Including the most important components of the Earth system in our ESMs will also allow TipESM to identify potentially unknown tipping elements, their precursors and impacts.TipESM brings together expertise from climate science and climate impacts to investigate both the role of gradual climate change for tipping in individual ecosystems and society, and the impact of crossing specific climate tipping points for society, ecosystems, and biodiversity. Project findings will be synthesised into a tipping points risk register. New knowledge and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Integrative omics of heart failure to inform discovery of novel drug targets and clinical biomarkers' in the context of a Horizon 2020 call.

assistant: **Objectives**

Heart failure is a leading cause of morbidity and mortality in the aging European populations. It is the end-stage of myocardial and valvular disease, arising from loss of viable or functional muscle cells in the heart. Therapy is complicated by the multitude of causes and comorbidities of heart failure. New therapeutic targets and clinical biomarkers to individually tailor therapy (‘precision medicine’) are greatly needed. This research program aims to realize the promise of precision medicine by applying an integrated proteomic, genomic and epidemiological approach to the underlying causes, mechanisms and consequences for heart failure. The program builds on unique Swedish nation-wide disease registers and large biobanks, the translational research profile of the investigator and experience in genomics, epidemiology and proteomics. The program includes five work packages: (1) comprehensive plasma protein profiling through a discovery pipeline including novel microarray-based methods and mass spectrometry in a population-based cohort of 6000 subjects and clinical cases to identify subjects at risk for heart disease (2) assessment of heritable components to outcomes in heart disease using nation-wide Swedish registers (3) genome-wide discovery of variants associated with risk of and outcomes in heart disease as well as endophenotypes for cardiac structure and function, using resequencing and DNA microarrays in large population-based cohorts including >70,000 subjects from three generations (4) expression profiling in human heart samples and a novel human cardiomyocyte strain assay to translate genomic and proteomic findings to understanding of pathophysiological mechanisms (5) evaluate the clinical importance of plasma proteins and genetic variants in >3000 clinical cas
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'The role of natural killer T cells in the early stages of the herpes simplex virus infection in skin' (2007-2013), addressing dissemination and exploitation.

assistant: **Impact**

The aim of this project is to examine how the local skin microenvironment influences the generation of antiviral immune responses following herpes simplex virus type 2 (HSV-2) infection. Genital herpes, caused primarily by HSV-2, has a worldwide prevalence and is the leading cause of genital ulcers. An increasing number of clinical and epidemiological studies indicate that a recent genital HSV-2 infection increases the risk of HIV acquisition and transmission by up to 3-fold. Therefore, further studies that examine the local immune responses to HSV-2 infection are necessary to elucidate the mechanisms of enhanced risk of HIV-1 acquisition and reveal possible strategies for the development of an effective HSV vaccine. Our project will focus in particular on the responses of human natural killer T (NKT) cells, which are poised to respond within hours of activation and can rapidly modulate cellular immune responses. We will examine the ability of NKT cells to respond directly to virus infection and how the virus can affect their function. In addition, we will investigate how cutaneous immune cell types influence NKT cells and their ability to modulate appropriate cellular responses against HSV-2 infection. A three-dimensional organotypic culture model of skin will be utilised to examine these interactions in a physiologically relevant setting, obviating the need for the use of animal models. This study will provide critical information on how the immunomodulatory activities of NKT cells could be utilised as a viable strategy for the enhancement of local virus-specific immunity and thereby develop better genital herpes vaccines.