RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Modular PTCA catheter system including stent to overcome the reliability and budgetary problems in European hospitals' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

Percutaneous transluminal coronary angioplasty (PTCA) is a method used to dilate occluded coronary blood vessels, stents are often used in addition to prevent sudden early vessel closure and to reduce the possibility of restenosis (re occlusion of the vessel. Problems are faced in the reliability of the stents used. Current type stents have some design and material problem which make theme hard to place and often need additional treatment to keep them in place or even remove theme again. Problems are also on the expenses budget. Hospitals use usually more then 1 catheter per patient. Due to treating more diseased vessels or placing a stent after dilation. The current balloons types do not refold enough to be used more then once. Since budgets are under pressure in Europe there is not sufficient funding to do all needed treatment. Therefore Occam has conceptualised a balloon catheter system which consists of three parts: a re usable shaft (the proximal patt). a disposable balloon section (distal part) and a new t,spe of stent. Balloon catheters are predominantly single use products. In Occam?s concept, the shaft is a tool to deliver the balloon to the stenosed arca. Since the shaft will be made of metal it can be re sterilised and re used many limes while the balloons themselves can be disposed of after each procedure. The balloon and the shaft will be kept together with a connector. The balloon needs to have better refolding characteristics without loosing the current market standards demands, so it can be used more than once on the same patient. The concept of the stent is to use a design which is easy to place and keeps it strongly fit into the vessel.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EU-India Platform for the Social Sciences and Humanities' to be submitted under Seventh Framework.

assistant: **Abstract**

EqUIP: the EU-India Platform for the Social Sciences and Humanities will bring together research funding and support organisations in Europe and India in order to develop a stronger strategic partnership. Europe and India have strong historical links, but its research collaboration relationships are relatively new. EqUIP will link and build upon the successful partnerships developed at the European level, using the NORFACE and HERA European Research Area Networks (ERA-NETs) as a focus for expanding interactions with India.The platform will support agencies across Europe and India in stepping up international collaboration:  through sharing best practice, networking and the closer coordination of existing collaborative activities and the establishment of new relationships. It will map existing collaborative activity with the aim of identifying barriers and challenges to effective research co-operation, as well as identify opportunities and priorities for future research collaboration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Geoanatomy. The Body as a Model in Greco-Roman Conceptions of the Earth and the Environment' (GEOANATOMY).

assistant: **Concept**

One of the most ancient, still puzzling, philosophical questions concerns how one should explain the structure of the surrounding world while being herself part of it. Believing that all bodies are part of the cosmos in the sense that they are governed by the same causal principles, ancient scientists communicated their observations by using analogy. Evidence of the various forms of communicative analogical scientific exposition is traditionally taken to reveal that medicine and natural science, though sharing a common interest in accounting for natural phenomena, manifest a keen eagerness to delimit their boundaries. There is, however, a largely underexplored type of analogical reasoning in which these disciplines are seen to create a trans-boundary scientific mixture, enabling us to speak of cross-disciplinary influence and assimilation. This project aims to determine the impact of ancient Greek and Roman medicine on the causal explanations of meteorological and geological phenomena offered by Aristotle (4th c. BCE), Lucretius (1st c. BCE) and Seneca (1st c. CE) by investigating the course of reasoning within which such explanations are embedded, what I call ‘the medical argument’. An analysis of this single, unified cross-disciplinary argumentative system will ultimately lead to a redefinition of our present historical knowledge about the beginnings of modern environmental conscience and consciousness. As its strategic intent, GEOANATOMY encompasses the following set of specific goals: (a) To reassess the relationship between ancient biomedicine and natural philosophy, two disciplines which are traditionally thought to have had clearly demarcated boundaries; (b) To bring to light for the first time and clearly identify the ‘fruit’ of this cross-boundary scientific co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantitative understanding of ozone losses by bipolar investigations' under Fifth Framework.

assistant: **Concept**

A good quantitative understanding of chemical ozone loss in the polar regions is necessary to predict reliably the future of the ozone layer. In the Arctic, ozone loss rates have been determined by a number of approaches during the past tenures. Recent comparisons with model calculations give reason to assume that threat of rapid ozone loss in the Arctic is not yet understood quantitatively under certain conditions. To further investigate the situation, models and observations have to be compared under a broader spectrum of meteorological conditions. Therefore we propose high precision measurements of chemical ozone loss rates not only in the Arctic but also in the Antarctic. The results will be compared with several state-of-the-art 3D chemical transport models and photochemical box models. The aim is to determine whether deficiencies exist and identify possible reasons. This may contribute to the development of better models for predictions.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Evaluation and demonstration of innovative city transport' (EDICT) targeting Fifth Framework.

assistant: **Abstract**

The programme-addresses the urgent need for sustainable forms of transport in cities in Europe as an alternative to the car and to complement existing forms of public transport. The evaluation of the technical, environmental, social and economic benefits of a novel Personal Rapid Transport (PRT) System will be undertaken in 4 European Cities, Cardiff Wales, Eindhoven Holland, Huddinge Sweden, and Rome Ciampino Italy. Seven further Cities in EC and Accession countries will participate as 'follower' cities. Practical assessment of user and community benefits will be accomplished through full-scale demonstration in Cardiff. The results will be disseminated widely to provide information on best practice for assessment and introduction of PRT systems to improve future transport in Europe.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Local and systemic mechanisms for metabolic inflammation chronicity' (LOSYSINCHRON), addressing dissemination and exploitation.

assistant: **Impact**

Chronic inflammation underlies several diseases and is a common basis of multiple comorbidities. In obesity, chronic inflammation of the adipose tissue (AT) and liver contributes to the metabolic syndrome and related metabolic-inflammatory pathologies. Here, we propose a thorough and innovative approach to revolutionize understanding of metabolic inflammation chronicity. We will address both local (at the respective tissue level) and systemic mechanisms, involving the novel principle of trained innate immunity (TII) and inflammatory adaptation of the bone marrow (BM). (i) Local: In chronic metabolic inflammation, there is an imbalance between chronic accumulation/activation of inflammatory cells and resolution of inflammation (RoI) in favor of the former. Based on our recent findings regarding integrin-dependent chronic macrophage retention in the obese AT and that Developmental endothelial locus-1 promotes RoI, we will here identify novel pathways towards counter-acting chronicity of metabolic inflammation and facilitating its resolution and test their therapeutic efficacy. (ii) Systemic: Systemic metabolic/inflammatory feedback to the BM may trigger long-term adaptations of hematopoietic progenitors, fueling a feed-forward loop of perpetual inflammation. Following our discovery that TII is initiated in the BM, we will pursue the hypothesis that maladaptive training of BM progenitors in obesity facilitates metabolic inflammation chronicity, via generation of myeloid cells with higher potential for tissue accumulation and inflammatory activation, and promotes development of obesity-related inflammatory comorbidities. Despite apparent links, local and systemic mechanisms are mostly studied independently of each other rather than through an integrative approach, which wil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Far-infrared semiconductor electronics' under Horizon Europe.

assistant: **Concept**

The project will establish frontline semiconductor terahertz electronics for far-infrared space instruments by exploring and combining InP-based semiconductors with thin silicon membrane technology. The goal is to obtain high receiver sensitivity and stability for much less power consumption beyond what is currently considered state-of-the-art in the 2-5 THz frequency range.Terahertz measurements of the atmosphere are made routinely to monitor and reveal physical and chemical processes related to weather and climate change. New space initiatives, using constellations of terahertz receivers on small satellites, can help to gain further data and insights about the climate system. For atmosphere science, there is a need for a terahertz receiver without active cryogenic cooling that can operate over a broad ambient temperature range with sufficient sensitivity and can make observations over a long time. For the supra-terahertz band (>3 THz), several challenges, such as power consumption and inefficient coupling to the terahertz radiation, leave a gap in semiconductor technology. Hence, future Earth and space science missions need new compact heterodyne receiver solutions with improved energy conversion efficiency.Millimetre wave, antenna-integrated, InP-based Schottky barrier mixers have shown high sensitivity at a small cost in power consumption (local oscillator). Still, InP-substrates are fragile and not suitable for supra-terahertz circuits. Therefore, combining robust, integrated silicon membrane technology with InP-based electronics can potentially revolutionise future space terahertz instrumentation. This approach will enable compact, efficient and advanced room-temperature heterodyne receivers for far-infrared space science instruments and trigger future research on
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Mobi-Dev: mobile devices for healthcare applications' (MOBI-DEV).

assistant: **Concept**

Mobi-Dev is a European effort which addresses the long standing and increasingly demanding need of health professionals to effectively, accurately, securely, from anywhere, anytime and in user-friendly way communicate with patients' databases located within hospitals, private offices, laboratories or pharmacies. To this end, an innovative integration of state of the art but also upcoming enabling technologies will be combined to combine the new generation mobile communication palm device for health professionals. Natural language understanding, electronic signature, smart card reader and UMTS and Bluetooth transceiver technologies will be integrated. Access restrictions and secure data transmission will be guaranteed. Mobi-Dev's marketable product will be exploited by business partners beyond the end of the Project in the European market, to the benefit of health care industry and quality of health of European citizens.Objectives:The objective of Mobi-Dev Project is to provide the new generation mobile devices for health care professionals. Mobi-Dev will ease and improve at many levels the daily routine of doctors, nurses, researchers, both inside and outside healthcare organisations, thanks to its innovative integration of new technologies, including mobile communication devices, natural language understanding and electronic signature.It will provide:.unlimited availability of patients data with the possibility to edit them any time and from everywhere;.possibility to retrieve in real time lab analysis results, without having to go to the information database storing them;.possibility to input data into structured format by direct speech in natural language;.input data authentication by electronic signature of the person that inputs them;.alarm features (early warning
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'A Photo-triggered On-demand Drug Delivery System for Chronic Pain' (NANOHEDONISM).

assistant: **Innovation**

Nerve pain affects millions of people, and can be personally devastating for people who experience it. Current methods for pain management (e.g. local injection of pain killers) are inadequate because of the short duration of action. Even sustained release treatments, such as drug-loaded liposomes, provide only one week of analgesia producing a continuous extended nerve blockade without allowing for changes in daily physical activity or level of pain relief. More importantly, such systems cannot be turned off until they run their course.In this proposal, a locally-injected or implanted near infrared (NIR)-sensitive drug reservoir that can be triggered by a simple handheld laser device applied externally is described. The device enables drug release with consistent response over multiple on/off cycles. Such a device, implanted (or eventually injected) on a nerve or near the neuraxis, could have substantial clinical impact in the treatment of chronic (or prolonged perioperative) pain.This system will consist of an impermeable ethylcellulose membrane embedded with temperature-sensitive polymer nanoparticles and NIR-active gold nanoparticles. The membrane will be engineered such that the nanoparticles form a disordered but interconnected network throughout. The gold nanoparticle concentration will be adjusted so that light-induced heating of the nanoparticles produces sufficient heat to collapse the polymer, thus opening the porous network. Those nanostructured materials which compose the device will be produced in a continuous manner by using microfluidic reactors to avoid the characteristic disadvantages when using conventional discontinuous (batch) reactors. Nanoparticle-synthesis protocols will be supported by computational fluid dynamics.The specific aims will be geare
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Spreading Open and Inclusive Literacy and Soil Culture through Artistic Practices and Education' to be submitted under Horizon Europe.

assistant: **Abstract**

SOILSCAPE harnesses the power of Cultural and Creative Industries (CCIs), artists, and civil society organisations (CSOs) to promote soil preservation across Europe and beyond. Working with experts from the worlds of soil sciences, arts, decision-making, and humanities, this project coordinated by AFES seeks to cultivate soil literacy and celebrate soils through creative approaches, engaging citizens & professionals on this journey. SOILSCAPE's objectives include understanding human-soil relations, building a network of more than 120 relevant actors in 8 countries, onboarding at least 320 individuals from the society, providing 1,850,000 € as financial and technical support to CSOs, CCIs, schools, artists, and institutions, distributing 375,000 € as awards and 80 soil literacy certifications to inspiring initiatives, and reaching international scales through UNESCO and Coalition of Action for 4 Soil Health. To achieve these objectives, SOILSCAPE uses a multilingual and multi-actor approach, focusing on cultivating artistic soil intelligence, promoting context-based soil literacy, enhancing awareness through innovative communication strategies and a soil literacy portal, organising 2 editions of national soil festivals across Europe, and extending its actions to 30 regions by 2028. The project unfolds through 4 key stages: (1) Contemplation: Consulting stakeholders to understand individual perception on soils, arts, and links with societal values; Investigating soil narratives and the potential of arts and arts-based methodologies to engage in soils; (2) Preparation: Developing people-centric transformative strategies, including an artistic and creative international soil network; (3) Action: Conducting and monitoring the SOILSCAPE creative activities, including the supp
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structure, properties and biotechnology applications of VHH antibody fragments from camelids' to be submitted under Fourth Framework.

assistant: **Abstract**

Since the development of (monoclonal) antibody technology, there have been major efforts to (de)construct or engineer these biomolecules to obtain smaller binding units that retained the specificity and affinity of classical antibodies. Two-domain variable fragments (Fv) or single-chain variable fragments (scFv) have been introduced, but large scale production of these fragments often led to accumulation of insoluble protein. A further decrease in size has been achieved by generating minibodies or single-domain VH fragments. The low solubility and tendency to aggregate of many such fragments, probably due to exposure to solvent of the hydrophobic surface normally facing the VL domain and/or the constant domain, have impaired the scale production. The naturally occurring antibodies devoid of a light chain and of a CH1 domain discovered in camelids constitute a promising and novel alterative in this domain, and represent a potentially valuable tool for applications in biotechnology. Following immunization of camels or llama and subsequent cloning of the variable domains of these heavy chain antibodies, antigen-specific recombinant heavy chain variable fragment (VHHs) can be produced as highly soluble monomers in heterologous organisms such as E. coli and yeast. Moreover, naive and/or dedicated synthetic libraries containing the VHH-repertoire can be constructed, from which specific binders can directly be selected. Recombinant VHHs have already been raised against both proteins and haptens, and these minimal-sized recognition units were characterised by a good stability and solubility and an affinity range of 10-7 to 10-8 M. Moreover, VHHs have been generated that were capable of specifically inhibiting the activity of their enzyme-antigen. Structural analysis of complexe