RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Interface design of metal nanocluster-carbon nanotube hybrids via control of structural and chemical defects in a plasma discharge' to be submitted under Sixth Framework.

assistant: **Abstract**

Based on a very recent set of exploratory experiments performed within the consortium, this project will take benefit of the numerous plasma discharge operating parameters combined with plasma diagnostic tools, to fine tune and understand the physical properties of the treatment, and CONTROL the INTERFACIAL (chemical and structural) DEFECTS that will rule the deposition and growth of METAL NANOCLUSTERS deposited in the plasma onto CARBON NANOTUBE surfaces.Nanoclusters with selected size, shape and density, will be prepared at different (small -large) scale in RF-cold plasmas, and in atmospheric dielectric barrier discharges from different precursors (organics, colloids and salt solutions) and fully and extensively characterized for their composition and electronic properties. The technology research will be backed up by modelling and theoretical calculations on graphene sheets, on gas-nanotube, metal-nanotube and metal-metal interaction at the nanoscale in order to understand, control, select and fine tune the reactivity (sensitivity, selectivity) of the material, for one type of selected application: chemical gas sensors.One partner will design, optimise and test nano2hybrids sensors for benzene selective monitoring at the ppb level (highly useful for oil industry) and detecting DMMP molecules (one Sarin gas model). A special effort is devoted to the integration of the tasks and promotion to the citizens, via multimedia tools, of the project in particular, but also of the nanoscience in general.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Analysis of Transferrin Conformational changes that Impact Virulence and Evolution'.

assistant: **Innovation**

Structural dynamics define the transition from one protein state to another and are modulated by interactions with partners-ligands and/or chemical modifications. They are important to control protein biological activity, govern protein evolution and their alteration can lead to diseases or death. The long-term objective of ATRACTIVE is to understand protein structural dynamics, their regulation and how such dynamics diversify a conserved structural core to evolve in computing distinct functions. For this, we will focus on human serum transferrin (hTF), which shares an ancient and conserved bilobed structural core composed of two domains from the type-II periplasmic binding protein domain family. This core is fundamental for maintaining iron-homeostasis in human cells conferring nutritional immunity. The same core is harbored by proteins ubiquitous throughout the tree of life that diversified yielding transcription factors, enzymes or transport related/signaling proteins. Bacterial pathogens to acquire iron from available sources, have evolved membrane receptors for capturing iron-loaded-hTF, transferrin binding proteins A and B (TbpA/TbpB). This interaction is essential for the pathogenicity of many critical human pathogens, such as Neisseria sp (gonorrhoeae, meningitidis). Our aim is to investigate the structural dynamics modulated by iron binding and release and how such are affected by the receptors in the presence or absence of drugs, following a three-pronged approach: a) Determine the structural dynamics of hTF upon iron binding in the two bilobed structures and uncover the allostery between them, b) Map the structural changes triggered by hTF-TbpA-TbpB interactions that underlie the iron release mechanism, c) Identify drugs that compromise the hTF-TbpA interacti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Metamaterials for Laminar Flow Control on a Wing' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Achieving extensive laminar flow can reduce aircraft drag by up to 15%, offering breakthrough potential for curbing polluting emissions in aviation and other energy-intensive sectors. To achieve this, wave-like flow instabilities growing in laminar boundary layers need to be controlled and attenuated, to delay transition from laminar to turbulent flow. However, their complex, multi-scale, and broadband nature makes these instabilities extremely challenging to control.In MetaWing I propose a new disruptive concept for flow control, first born in classical wave physics: Metamaterials. These are engineered composite structures, invoking dispersive wave phenomena to gain exotic properties that go beyond what is considered possible in Nature. The main such property I want to explore is the bandgap, a range in which waves are suppressed when interacting with the Metamaterial. My team and I have recently found key evidence of dispersive wave suppression in boundary layers. However, wave-like flow instabilities have key differences from classical waves, forming a new regime of dispersive wave interactions. Thus, the nature of bandgaps in boundary layer flows remains unclear and unexplored.  I aim to reveal and understand the formation of bandgaps in transitional fluid flows and use them to suppress wave-like boundary layer instabilities, thus delaying laminar-turbulent transition. To achieve this, I propose the first holistic intersection of Metamaterials and Laminar Flow Control using theory, numerical simulations, novel fabrication methods and state-of-art experimental measurements. The combined results will uncover the complex dynamic behaviour of flow instabilities under dispersive interaction with Metamaterials and will help us understand and fully exploit bandgap mechanis
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Marie curie training site for thermofluiddynamic processes in diesel engines' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The CMT- Departamento de Maquinas y Motores Tennicos of the Universidad Politecnica de Valencia is a very active group involved in research related to thermo-fluid-dynamic processes in reciprocating internal combustion engines. CMT is well recognized at international level. It is fully equipped with state-of-the-art experimental facilities. It works closely with the automotive industry and co-operates in 6 European projects.The CMT Group offers doctoral training in two areas related to research on reciprocating internal combustion engines:Training 1: in experimental analysis of internal combustion engine exhaust noise It includes:- Calibration and set-up of acoustic instrumentation (condenser microphones, intensity probes, binaural torso for subjective assessment)- Noise measurements in a semianechoic chamber especially conceived for exhaust noise studies. This includes training on the management and control of the engine during the tests- Training in advanced spectral and time-frequency signal processing techniques (Hilber, Wigner, wavelet transforms, etc.) Applicants should have basic notions in Acoustics and some knowledge of MATLAB.Training 2: in basic and applied research in the injection and combustion processes in Diesel engine It includes:- Basic research on injection and combustion in Diesel engines- Application and improvement of diagnostic and predictive calculation models.- Development of test routines in steady and transient engine operation.- Evaluation of engine performance and emissions in transient operation Applicants should have a good knowledge of Thermodynamics, preferably applied to engines. Candidates must be in possession of a good university degree allowing them to register for doctoral studies. They should be willing to learn Spanish and speak
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Numbers in the brain: the impact of brain lateralization on numerical abilities' under Horizon 2020.

assistant: **Concept**

Understanding the neural correlates of number cognition is of both intellectual and societal importance: number cognition gives fundamental insight into the evolution of cognitive processes and poor numeracy limits life chances and is a substantial cost to nations.However, the neurological basis of number processing is poorly understood. Furthermore, despite brain lateralization being associated with dyscalculia, an arithmetic learning disorder, the exact impact of brain lateralization on numerical skills is unknown. NUMELAT aims to investigate the neural circuits underlying numerical competence and how these are affected by brain lateralization using zebrafish as a model system. Zebrafish are indeed able to assess numerical magnitude, show lateralized behaviours and it is possible to image neural activity in vivo in behaving larvae. The project will: 1) test whether laterality affects the development and extent of number cognition by: (i) determining the impact of laterality on zebrafish’ ability to assess numerical magnitude. The effect of brain lateralization will be determined by comparing the performance in wild-type and laterality mutant lines. (ii) determining the impact of laterality on developmental trajectories of numerical abilities in wild-type and laterality mutant larvae. 2) Identify neural circuits involved in number processing in wild-type and mutant lines using in-vivo neuroimaging in larvae while assessing numerosity. The use of a species whose genome is sequenced and whose nervous system has been extensively studied will introduce the zebrafish as a model for the study of neurobiology of numbers, with particular regard to the cognitive dysfunctions related to brain lateralization, such as dyscalculia. By combining behavioural analysis and in vivo imag
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'TWO-PHASE FLOW IN FRACTURE CARBONATE RESERVOIRS' (1994-1998).

assistant: **Concept**

To test and demonstrate the application of an integrated range of new technologies for the appraisal and development of tight carbonate oil reservoirs. These technologies provide a unique capability for enabling economic production from marginal fields and consequently have a high potential commercial value.This new workflow process integrates a range of new and established methods, tools and data from all relevant sources (geoscience, reservoir technology, fluid mechanics) to establish the effects of barriers and conduits for fluid flow due to the dispositions of reservoir heterogeneities, of which the most important are due to fracturing, enabling selection of optimum well locations and directions.The demonstration site is a unique location at which a natural reservoir can be accessed at a shallow level, allowing testing, measurement and demonstration on true reservoir lenght and time scales with natural oil and water saturations.A subsurface fracture and flow model of this demonstration reservoir will be created, consistent with the various data.This natural laboratory site (Portugal) has possibilities for future experimental use as a full-scale reservoir analogue. A contribution is foreseen to solution of the environmental problems due to oil surface pollution and acquifer contamination at the test location and elsewhere.At the first six months period of project the work was focused on geological and seismic data collation and quality control in order to proceed to the construction of a first geological and structural model for the area of interest.General outcrop and well data analysis have been carried out by examining all the existing material such as maps, old sections, well cores, aerial photographs, well logs and other petrophysical data.From field observation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'human pluripotent stem cell registry - hPSCreg' under Horizon Europe.

assistant: **Concept**

The human pluripotent stem cell registry (hPSCreg) is providing validated information about human embryonic stem cells (ESC) and other human pluripotent stem cells (PSC) such as induced PSC. This information is linked through an unique persistent identifier and it includes data on ethical provenance and scientific quality, cell line application and clinical studies performed with hPSC. The open access Registry acts globally to provide a transparent resource and tool for PSC, to maximize cell utility, reproducibility and benefit and minimize research, ethical and regulatory risks. It validates and certifies the registered cell lines based on the provided documents, data and information, assuring high quality of certified lines. hPSCreg is involved in multiple EU-Projects,  international consortia and organizations to provide information, data standards and support dissemination. The main task of hPSCcreg within this project proposal are to maintain and improve its function as a centralized registry of hESC and hiPSC lines allowing for (i) transparent validation and monitoring of the ethical and scientific developments in the field; (ii) transparent data – based certification of PSC to assure and maintain highest quality; (iii) implementing FAIR data standards and a continuously improved data reliability in downstream stem cell research; (iv) supporting academic, industrial and clinical research on PSCs and maximizing their  potential; and (v) inclusion of diverse stakeholders in the communication process on emerging PSC - based technologies, including research towards clinical applications.


**Keywords:** pluripotent stem cells, database, data management, stem cell registry, ethics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Chinese Agricultural Transition: Trade, social and environmental impacts' (CATSEI).

assistant: **Concept**

The project studies the impact of China's current economic transition on its agricultural economy with special reference to the consequences of trade liberalization and of changing trade flows.  The project will track impacts on social conditions and on the environment in China's rural areas as well as on markets in the rest of the world, with particular emphasis on the EU. For this, the research considers (a) the dynamic, rapid pace of the transition; (b) the size and geographical diversity of the country; and  (c) the effect of the changes on the rest of the world. The research opts for a quantitative approach, supplemented by qualitative investigations, and focuses on three themes: trade, social conditions, and environment.  On trade, the research aims to account for the size of China's trade and take a closer look at trade between the EU and China with scenario simulations over the period 2000-2030, by establishing a linkage between  (a) the China agro-model, a spatially explicit equilibrium model that comprehensively depicts China's farm sector in 2433 counties, while connecting these through trade and transportation flows;  (b) the GTAP-model of world trade;  (c) FEA-27, a model of EU-agriculture for 27 members states. The research on social conditions proceeds by linking geo-referenced household surveys to a population census of China and a detailed geographical data set, relying on a suitable adaptation of poverty mapping methodology, so as to trace impacts at household level.  Finally, we use agro-ecological assessment tools to quantify the environmental pressures resulting from intensified livestock industry as well as from intensified horticulture production. Findings on the three themes are subsequently integrated to arrive at policy suggestions that account
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Improvement of cement physical and mechanical properties for durable zonal isolation'.

assistant: **Objectives**

Research objectives and content This project addresses a major problem of the oil and gas industry - long-term zonal isolation in high-temperature high-pressure wells. A main goal is to develop a model to predict cement expansion and the associated mechanical behaviour during setting. To achieve this, an innovative experimental study of the mechanisms of cement paste expansion and shrinkage will be carried out, and additives developed for controlling these processes and hence the final compressive stress state of the set cement. The output from the work will give the oil industry for the first time a field-validated robust cementing product for durable zonal isolation. The consequences will be reduced well costs, increased safety, and lower environmental risk. Training content (objective, benefit and expected impact) I will benefit from training in a multidisciplinary environment with experts in chemistry, solid mechanics, materials science, and information technology on a project that requires many aspects of these to be integrated. Working in an industrial environment I will learn directly how to apply sound scientific work to practical applications. The project will also involve contact with other European research centres, universities and oil companies eager to collaborate on and apply the output from this project. The field validation phase will give me first-hand experience of oilfield operations. Links with industry / industrial relevance (22) Being directly in relation with North Sea Field operators will bring me a full overview of the oil industry world. This project is of great importance because it contributes to increasing oil resources potential as well as with dealing with environmental problems.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'On the Chemical Evolution of Proto-Bioenergetic Systems' (Evo-PBS).

assistant: **Innovation**

Contemporary biochemistry exploits condensed polyphosphates (e.g.: adenosine triphosphate, ATP) to drive metabolic processes. However, it is unlikely that such molecules emerged a priori from an abiotic environment as their synthesis and use requires the presence of sophisticated & complex protein catalysts. We propose that more primitive P-based chemicals pre-dated ATP, chemicals which (i) emerged readily from prebiotic environments, (ii) were capable of performing valuable (in the context of an emerging living system) chemical reactions and (iii) had the ability to evolve chemically into peptide-catalysed polyphosphate-based systems more common to contemporary life.We have identified a candidate P-based chemical pyrophosphite [PPi(III)] for which we have plausible prebiotic provenance. We will explore here the ability of PPi(III) to couple prebiotically available amino acids to peptides with potential value to an emerging system. We know that PPi(III) will couple glycine to diglycine but we intend here to explore the complete amino-acid coupling space using robotic, parallel processing, multi-well reader technology to probe PPi(III)-mediated di, tri and tetrapeptide formation. These libraries will then be examined, in a feed-back loop, for their abilities to catalyze the hydrolysis of PPi(III). The significance of this is that polypeptide catalyzed polyphosphate hydrolysis represents a primitive mimic for the activity of contemporary ATPase enzymes. We will then explore the ability of PPi(III) to evolve chemically into pyrophosphate [PPi(V)], a closer cousin to ATP, in the presence of PPi(III)-generated peptides and explore the abilities of the peptide libraries to accelerate chemical reactions of PPi(V). In this way, we aim to chart a chemical evolutionary pathway to