RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Developing broad-spectrum antiviral drugs for pandemic preparedness' (PANVIPREP) under Horizon Europe.

assistant: **Objectives**

Antiviral drugs will be key in the management of future virus outbreaks. For each virus family with epidemic/pandemic potential, stockpiles of potent drugs are needed that can be deployed when a new pathogen emerges. Such broader-acting drugs (targeting conserved viral functions) are needed as of “day one” of an outbreak, for treatment and prophylaxis (e.g., in HCW and frail patients). In combination with quarantine measures, such drugs will delay (global) spread, allowing time for vaccine-development. Since the 2003 SARS outbreak, PANVIPREP’s core partners have successfully collaborated in leading European antiviral drug research projects. This provides a solid scientific basis in combination with translational drug discovery expertise. The team includes virologists, biochemists, structural biologists, medicinal chemists and pharmacokinetics experts. Previously developed know-how and toolboxes will be a major asset to achieve immediate impact. PANVIPREP aims to greatly expand the antiviral portfolio and identify novel druggable targets of high-risk RNA viruses. Hits will be identified through (i) phenotypic antiviral screening of compound libraries (ii) structure-based drug design, (iii) in silico screening, supported by the latest machine-learning methods. We will deliver 25 to 50 high-quality, broad(er)-spectrum (pan-genus/pan-family) hit molecules/hit series. Two of these will be developed to the early lead stage, including proof of concept in animal infection models. Remaining hits will serve as chemical tool-compounds to explore mechanisms of action thereby identifying novel druggable targets in RNA virus replication. This in turn will accelerate target-based drug design efforts. The workflow will integrate best practices in antiviral drug discovery with a range o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Boundary Phenomena: Harmonic Measure, Unique Continuation and Area Minimizing Currents' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

The study of harmonic functions is a cornerstone of partial differential equations. This project pursues three connected threads related to boundary behaviour: (i) harmonic measure, where we study its dimension and quantitative stability; (ii) boundary unique continuation for harmonic functions, extending Bers’ theorem in the plane to elliptic operators and improving unique continuation results for Neumann problems in rough domains; and (iii) boundary regularity for area-minimizing currents, in both the real-analytic setting (towards White’s conjecture) and the smooth case. These threads are closely connected through multiscale oscillation and propagation of smallness phenomena, and progress on them would mark significant advances and open new directions in analysis, geometry, and PDE.


**Keywords:** Harmonic measure; boundary unique continuation; area minimizing currents; geometric measure theory; harmonic analysis; elliptic partial differential equations.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Investigating Pleistocene population dynamics in the Southern Caucasus' (TransCause) targeting Horizon 2020.

assistant: **Abstract**

Over the past 25 years, knowledge of the origins, evolution and diversity of our species has increased dramatically. Yet, the behavioural mechanisms enabling their global expansion and ability to cope with ever-increasing ecological diversity are still not fully explored. Armenia, a little studied biodiversity hotspot of Eurasia, is an ideal natural laboratory for testing models of climatic impact on hominin settlement patterns and population dynamics due to its location at the crossroads of the Pleistocene hominin world. TransCause aims to expand the framework of population dynamics by building an intra-regional comparative database of Paleolithic occupations incorporating biological evolution of macro-and micro mammals using ancient DNA, as well as establishing refined environmental frameworks. The TransCause project focuses on two main research questions, what are the impacts of long-term climatic and environmental changes on hominin behavioural repertoire and population dynamics? And what are the adaptations of Pleistocene hominins to changing seasonal resource availability in the landscapes of Armenia? Past hunter-gatherer’s social networks would be studied as a possible solution for populations coping with such terrains. The results of the project will test the presence or absence of population resilience over time; moreover, it will evaluate hypotheses on hominin behavioural responses to variation in resource availability using multi-scalar models; ultimately, those results will examine and compare the population dynamics of humans, large mammals and small mammals against the backdrop of paleoenvironmental oscillations. Examining the ecological tipping point of survival in both hominids and mammals will change the way in which we grasp hominin population dynamics
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RHeophysics and Energy of mAgmas' to be submitted under Seventh Framework.

assistant: **Abstract**

To understand dynamic earth processes it is necessary to first understand how magmas flow. Volcanology, geodynamics and planetary sciences all need to know at which stresses magma will behave in a ductile or brittle manner and, even more importantly, the range of the transitional brittle-ductile field.With RHEA we aim to separate the stable from the metastable flowing field of crystal bearing melts and estimate the onset of brittle behavior. This question will be addressed by investigating experimentally and numerically the energy distribution within magmas. For the first time we will be able to reproduce numerically the real behavior of samples deformed at high pressure and temperature. We will thereby obtain much better comprehension of the processes involved during magma deformation.This project involves collaboration between excellent universities in Europe and USA: the ETH Zürich renowned for its experimental expertise and the UC Berkeley for the originality of its numerical methods. Combining the individual strengths of these two groups will allow us to develop one of the first numerical rheometers for magmatic suspensions based on real measurements and to formulate new constitutive laws for larger scale models.During the return period, we aim to experimentally test our results on real volcanic systems and to better constrain how the overall change in rheology may explain transitions in eruptive styles.This project will develop new models applicable to a broad range of earth science disciplines. It will allow a better prediction of volcanic eruptions and the results obtained will be invaluable in supporting decision-making during crisis events.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Training research pioneers by utilizing and validating the promise of electroporation for minimal invasive oncological treatments.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The ElectroPros action aims to optimally prepare young researchers for the evolving technology in the healthcare space, especially related to minimal invasive oncology therapies, by offering a unique set of targeted interdisciplinary training and research assignments in the areas of biophysics modelling and simulation, device physics, optimization algorithms, software integration and experimental validation. Four European Industrial Doctorate positions are offered to Early Stage Researchers (ESRs) for a period of three years. In the training program a combination of industrial, academic and clinical research environments are provided by Philips, the University Clinic Aachen and RWTH Aachen, to explore the field of electroporation, as a new and promising technique for minimal invasive oncology treatment. Based on sound career development plans, and coached by experienced supervisors, the four ESRs involved will develop a competence profile which will springboard their future career in the wide European medical community in the industrial, clinical and academic domain. These researchers have the potential to become pioneers for new minimally-invasive therapies for the oncology domain.During their training, the ESRs will work on electroporation based treatment of cancer. The ESRs address shortcomings of the currently available equipment to enable for the first time ever a reliable patient-specific electroporation based treatment for cancer. With a focus on liver cancer, the ESRs will collectively establish novel insights on the biophysical effects on various tissues, important to understand the treatment effect, and integrate this knowledge in optimal device (needle) design and multi-physics models for treatment outcome prediction and inverse planning algorithms. Furthermo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'EO in Malaria Vector Control and Management' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

“In Africa today, malaria is understood to be both a disease of poverty and a cause of poverty."" Nevertheless, malaria is a preventable and curable disease. According to the Abuja declaration, the goal is to halve malaria mortality in Africa by 2010.” (WHO, 2008, Status Report on Malaria in the African region). This report also states that most of the African countries within the region are attempting universal access to malaria prevention and control in the at risk areas. Fundamental is the control and management of the vector. There is a need for accurate and effective monitoring and evaluation systems as a resource to inform decisions that will assist in achieving these goals. Partnership between and within countries are essential to assist with access to and sharing of resources.The primary objective of MALAREO is to develop technology and implement EO capacities within malaria vector control and management programs in southern Africa. To achieve this objective, knowledge exchange and capability will occur in two directions (EU <-> SA). By doing this, the project will contribute to the installation of an EO monitoring cell that will support the daily work of the national malaria control programs.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Bio-Inspired Glycan-NanoProbes as Antimicrobial Pro-Drugs' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Methods for specific recognition and targeting of bacteria are of key importance in developing approaches to counter the growth of antimicrobial resistance (AMR). Cell surface carbohydrates play key roles in cell recognition mechanisms and bacterial adhesion. These key interactions typically exhibit high specificity and weak affinities toward their carbohydrate ligand. This low affinity is compensated in nature by the architecture of the protein, the host presenting the carbohydrate ligands in a multivalent manner or as clusters on the cell or mucosal surface. Glyco-nanomaterials offer the possibility of attaching several different molecules to the same nanoparticle while controlling the relative densities of these ligands. Recently, the Galan group demonstrated that a simple disaccharide, such as lactose can act as a “Trojan horse” on bi-functionalized fluorescent nanopartiples (CdSe QDs) to help intracellular delivery of other non-internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway. Following this, the group has developed a new class of water-soluble, non-toxic fluorescent carbon-based nanomaterials which are easily accessible from cheap carbohydrate starting materials and more excitingly, preliminary data have shown that these new carbon nanodots are able to label both Gram-negative and Gram-positive bacteria. Based on these exciting results, the aim of this project is to develop a new class of glycan-based nanoprobes for labelling and delivery of antibiotics into bacteria. The glycan-based nano pro-drugs will be evaluated in bacterial binding and killing assays and screened for selective labelling and drug release using confocal microscopy and TEM. This is a multidisciplinary project involving synthetic organic and materials
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'ENDORSE (ENergy DOwnstReam SErvices) - Providing energy components for GMES' (ENDORSE) targeting Seventh Framework.

assistant: **Abstract**

The project ENDORSE aims at a user-driven development of downstream services in renewable energies by exploiting the GMES Core Services (MACC, SAFER and Geoland 2) together with other EO/in-situ data and modelling. It addresses regional services promoting the energy use from sun, wind, and biomass, electricity grid management and building engineering through daylighting in buildings. The consortium has teamed with relevant users to stimulate the development of sustainable and transferable downstream services. ENDORSE will 1) develop and validate pre-market downstream services in collaboration with well-defined end-users by performing R&D activities; 2) assess the conditions for self-sustainability of these services through surveys and workshops with end-users; 3) disseminate the achievements of the project to foster the use of Core Services data and other EO data by the renewable energies community; 4) stimulate the market of downstream services in renewable energies towards the end-users community, and the development of such services by SMEs and other service-oriented companies by demonstrating precursors with documented conditions of sustainability. The expected major outcomes of ENDORSE are 1) scientific advances in assessment of surface air temperature and solar radiation, and data fusion; 2) a set of validated and documented innovative methods exploiting Core Services data and other EO data; 3) a portfolio of pre-market services, serving as precursors and examples of best practices for similar downstream services (other regions, other providers), with documented conditions of sustainability; 4) a stimulation of the renewable energies community towards exploitation of Core Services data and other EO data; 5) a stimulation of the service industry towards development
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Introducing an object-oriented graphical user-interface-builder' (GUIB) under Fourth Framework.

assistant: **Objectives**

R&HS has a yearly turnover in the maritime market of turn-key electrical systems of about 50 million ECU. This turnover can only be maintained by innovating their products, especially the automation (including monitoring and control) parts, which forms the heart of complete electrical installations.. The automation parts comprise 10 to 20 percent (5 to 20 million ECU) of the complete systems, requiring about 30 man-year programme development on yearly basis. Besides this maritime market, R&HS is active in the field of traffic control systems and factory automation. Also in these markets the same amount of development is required, resulting in a total amount of 60 man-years in software developmentTHE EXPERIMENTWithin this PIE-project R&HS wants to introduce a graphical user interface builder (GUIB), that should create more sophisticated, flexible, maintainable and reusable software for GUI's, to realise customer demands. The introduction of a GUIB, that is based upon object oriented (O&O) methodologies, will have an important effect on the current software architecture. Furthermore, software engineers of R&HS will have to be trained in using GUIB and O&O methodologies in the current software engineering process. The whole realisation of this introduction of GUIB and Object Oriented Technology (OOT) in the current software process will be the main objective of this ESSI project. Once this GUIB is installed, it will be used in the baseline project UNIMACS 3000, a development project for a totally new concept for controlling all functions on the bridge of large ships.EXPECTED IMPACT AND EXPERIENCEThe benefit of using GUI-builders within the baseline project is, that the organisation will become familiar with the new design philosophy of object oriented (O&O) software develo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Monitoring Arctic Land and Sea Ice using Russian and European Satellites' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The objective of the MAIRES proposal is to develop methodologies for satellite monitoring of Arctic glaciers, sea ice and icebergs. Methodologies to retrieve quantitative information from the ESA and RKA data will be developed, and examples of satellite derived products for each of the three thematic areas will be presented. The main satellite data will be Synthetic Aperture Radar (SAR), optical and infrared images, radar altimeter data, passive microwave data and geoid data from GOCE. Results from the proposal can contribute to improved understanding of climate change and provide useful data for scientists, policy-makers and the general public. The MAIRES project will demonstrate the benefits of combining Earth Observation data from European and Russian satellites for operational mapping, interpretation and forecast of land and sea ice variations in the Eurasian Arctic. Satellite-derived data collected over many years can show seasonal and interannual variability of land ice, sea ice and icebergs. The results will be disseminated to users groups including climate research and operational users. The project will establish cooperation between ongoing GMES projects related to the cryosphere and Russian scientists, users and stakeholders.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Development of multifunctional microprobe arrays for cerebral applications' (NEUROPROBES).

assistant: **Concept**

The NeuroProbes Integrated Project proposes to develop arrays of multifunctional microprobes for high temporal and spatial resolution brain studies that include freely moving subjects. The arrays will incorporate a third dimension in the form of multiple electrodes along their shanks and individual depth control. Microprobes will be designed for insertion in any part of cerebral cortex, including sulci of highly folded cortices such as those of humans.They will integrate advanced features such as microfluidic channels for drug delivery, fine depth control, telemetry, and biosensors to ultimately provide electrical recording and stimulation as well as chemical sensing and stimulation. The technological development of such novel implementations will be done in coordination with biological experiments; array configurations will be specifically designed to support the experiments and their designs will be refined based on the results.Microelectrode arrays incorporating multiple functions and telemetry were never before available to neuroscientists. Having three-dimensional recording capability by itself will permit the most complete mapping of local circuitry in the brain to date. Further, mechanical features proposed in our project such as the precise depth control both during insertion and in chronic use are highly desirable but have never been implemented. This is the first time that a concentrated effort between technologists, neurophysiologists and industrialists addresses such integration.Specific clinical demonstrators will be included in the project; in particular we will be investigating the use of our new system in vision restoration of profoundly blind patients. Furthermore, the dissemination of the technological outcomes of this project can have an enormous impa