RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'European Researchers' Night in Turkey' to be submitted under Sixth Framework.

assistant: **Abstract**

The overall objective of the proposal is to organize the first Researchers' Night in Turkey in order to provide the general public and in particular, young people with the opportunity to meet researchers within the context of festive and out-of-the-ordinary" activities.The ultimate aim is to enhance public recognition of researchers and their role in society as well as to encourage more young people to embark on careers in science and consequently to increase Europe's (and Turkey's) attractiveness as a p lace of work for researchers, while providing a wider public awareness about the EU support to science & research.Considering the very fact that few young people are attracted to careers in science, EUREN-TR aims to address the Turkey dimension of this European-wide public awareness campaign. The project objective will be achieved by activities designed to attract and entertain the participants of different age groups and backgrounds and to deliver them the main message that "researchers are normal people".The strategic objectives of EUREN-TR will be:- to organize the first European Researchers' Night in Turkey,- to address a large public with particular attention to young people (age group of 12-20),- to enhance public recognition and respect o f researchers and their roles in society, through extensive media coverage,- to create an awareness for the resources EC devotes to science and research and the improvement of working conditions for researchers,- to encourage the young people to embark on scientific careers by introducing possibilities in new careers,- to emphasize the importance of science for further development of technology and industry.The project will promote the activity and increase awareness of general objectives prior to the event, organize festive and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Towards middle-range theories of the co-evolutionary dynamics of multi-level social-ecological systems' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Humans have the capacity to change the biosphere from local to global scales while at the same time fundamentally depending on a functioning biosphere for their well-being. Moreover human societies are increasingly affected by global change and adapting to it in multiple ways. These interdependencies give rise to non-linear, cross-scale dynamics that pose significant challenges for analysis and governance of social-ecological systems (SES). In view of the need for societal transformations towards sustainability is the identification of mechanisms of change in SES an urgent and cutting-edge research frontier.  This project aims to develop new methodologies and middle-range theories of the dynamics of SES. It will take the nature of SES as complex adaptive systems into account by developing a mechanism-based understanding of change in SES as it arises from micro-level interactions within complex networks of actors and ecosystems. Particular emphasis will be put on emergent and top-down cross-scale interactions.   To this end we will develop dynamic multi-level models using agent-based and mathematical modeling approaches. Model development will be based on a typology of cross-scale interactions, theories from the natural and social sciences and empirical evidence from marine and terrestrial SES. We will combine stylized with empirically-based models and cross-case comparison to develop a typology of social-ecological configurations of the long-term persistence of SES and their capacity to change. Knowledge integration across disciplines and the development of integrative frameworks and approaches will be supported by procedures to bridge different ontological and epistemological foundations. The project will advance sustainability science by providing new methods for mode
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Obesity and gastrointestinal adenocarcinomas: the independent and joint roles of dietary phytoestrogens and fibres' (OGAPEF) under Seventh Framework.

assistant: **Objectives**

The male predominance of adenocarcinomas in the gastrointestinal tract remains enigmatic. Sex hormonal influence might play a key role in explaining this pattern. Phytoestrogens, the plan derivatives with estrogenic properties, have shown clear anti-carcinogenic effects in vitro and animal studies. Interestingly, phytoestrogens especially lignans (abundant in western diet) are generally found in fibre-rich plant food. Whether phytoestrogens exert an independent effect or play a joint role together with dietary fibre are largely unknown. Phytoestrogens and fibres are both correlated with obesity which indicates a potential interaction. The planning project is to integrate the increasing knowledge of dietary phytoestrogens and fibres with obesity to interpret the gender-specific incidence patterns of gastrointestinal adenocarcinomas. Two studies using data from EPIC (the European Prospective Investigation into Cancer and Nutrition) and one pooled study from several prospective large cohorts in Europe and other countries are planned to achieve the study objectives. Two questions will be examined: 1) how and to what extent phytoestrogens and fibres (dietary measurement using questionnaires and biomarkers) independently or synergistically, interaction with obesity (anthropometric measurements and adipokines) and H.pylori, contribute to the gender specific incidence of gastrointestinal adenocarcinomas, 2) whether diet, obesity and gut flora or more factors contribute to the abrupt increase of the duodenal adenocarcinoma in the recent decades. The expected results may shed light on the causality of gastrointestinal adenocarcinomas and facilitate the understanding of independent or synergistic roles of phytoestrogens and fibres interaction with obesity in the cancer etiology an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Plan of Action - a Strategic Portal to Research Excellence' (PASPORT) under Seventh Framework.

assistant: **Objectives**

One of the key problems that the European Research Council and the scientific communities are facing is overcoming the fragmentation of research activities, programmes and policies across Europe. Being one of the convergence regions Bulgaria as a new member state needs considerable efforts and support to reach and sustain a competitive edge in knowledge and innovation. The research staff at Institute of Polymers who have been benchmarking with their colleagues from the most developed countries for years do have the capacities to make a worthy contribution to ERA. Therefore the Institute undertakes this project for evaluating its research potential and successive developing of an Action Plan. The project is relevant to the call “Providing evaluation facilities for research organization in the EU´s convergence regions and outermost regions” and is in congruence with the National Strategic Reference Framework (NSRF) 2007-2013. The goals of the project are to produce an objective-driven SWOT analysis made by independent EU experts and drawing up of an Action Plan. The Action Plan will outline a framework of policies and measures with a view to intensify the process of strengthening the capacities of the Institute and contributing to the realization of the full research potential of the enlarged European Union. The set actions for immediate implementation of an integrated and responsible strategy will facilitate the successful participation of the Institute in the research activities at EU level.  The expected outcome from the project implementation is turning IP-BAS into a center having a better performing research organization, knowledge generation, innovation of research management and communication patterns.  The resulting knowledge will be applied in the benefit of soci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'An extended Value Chain model  for performance Prediction and Optimisation  of product and process Lifecycles for SMEs' (VALUEPOLE).

assistant: **Innovation**

At any moment in time, the decision makers within SMEs have a wide range of development opportunities available to them to advance the competitive position of their firm. These opportunities typically include development of new products or the improvement of their process performance. However, it is very difficult to determine, ex-ante, to which combination of improvement opportunities they should devote resources in order for the firm to maximise its performance. The ValuePOLE project is focused on delivering a Model, an ICT Tool and a Methodology to answer this challenge for the SME decision maker so that they can maximise their competitive position with the minimum investment of resources. ValuePOLE, delivers  - a new Predictive Performance tool for SMEs, to maximise value creation in the entire product, process life cycles. (ValuePOLE will maximise value creation by providing an infrastructure for the ex-ante, i.e. before the event, prediction of performance outcomes in planned innovations). - a model for performance Prediction and Optimisation of the product and process Lifecycles in SME value chains. - a methodology that goes ‘beyond lean’ in that it enables organisations to better deploy its resources to be both operationally effective through the selective application of improvement methodologies to current organisational configurations for today’s customers as well as strategically flexible in the adaptation of new configurations of products, processes, technologies, competencies, and systems that enable the satisfaction of tomorrow’s customers. ValuePOLE will support organisations for improvements in processes and innovations in products based on either existing or new technologies.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Advanced DNA imaging: improving spatial resolution and contrast through photoswitching' (IMAGINDNA).

assistant: **Concept**

Fluorescence microscopy is one of the most convenient and widespread tools used in the life sciences. An important challenge, however, is to improve its spatial resolution, which is limited to about 200 nm. Recent “super-resolution” techniques such as photoactivation-localization microscopy (PALM) can provide images with a spatial resolution of tens of nm. Most studies performed with these techniques have imaged the nanoscale distribution of proteins. However, little progress has been seen on DNA super-resolution imaging due to challenges in labelling. My main research is aimed at exploring new ways to label DNA in high density with photoswitchable fluorophores and improving spatial resolution in fluorescence microscopy. This will allow opening up new opportunities to study a broad range of problems in Biology and Nanoscience. My recent work has shown that PALM-like imaging of DNA can achieve a spatial resolution below 40 nm by using intercalating cyanine dyes in combination with a buffer that promotes photoblinking. This proposal aims at optimizing this approach, and at finding new alternatives for DNA super-resolution imaging. I propose two research lines: 1) Use correlative atomic force microscopy and PALM-like imaging to optimize the above methodology. As first targets, DNA origami will be used. Correlative microscopy will then be applied to study chromosome structure; 2) Study the photophysical properties at the ensemble and single-molecule level of a new material, CyDNA (DNA highly substituted with cyanine dyes in a controllable way). Bringing together Cy3 and Cy5 dyes in the same CyDNA with high density results in a photoswitch with new properties. CyDNA photoswitching will be used for super-resolution imaging in combination with fluorescence in situ hybridizatio
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'EXaSCale smArt pLatform Against paThogEns for Corona Virus' to be submitted under Horizon 2020.

assistant: **Abstract**

The EXSCALATE4CoV (E4C) project aims to exploit the most powerful computing resources currently based in Europe to empower smart in-silico drug design. Advanced Computer-Aided Drug Design (CADD) in combination with the high throughput biochemical and phenotypic screening will allow the rapid evaluation of the simulations results and the reduction of time for the discovery of new drugs. Against a pandemic crisis, the immediate identification of effective treatments have a paramount importance. First, E4C will select through the EXSCALATE platform, the most promising commercialized and developing drugs safe in man. Second, select from >500 billion molecules new pan coronavirus inhibitors. The huge computational resource, therefore the activities will be supported and empowered by three of the most powerful computer centers in Europe: CINECA, BSC and JÜLICH. The Swiss Institute of Bioinformatics (SIB) will provide the homology 3D models for the viral proteins. The Fraunhofer IME will provide the BROAD Repurposing Library and biochemical assays. Phenotypic screenings will be run by KU LUEVEN to identify molecules capable of blocking virus replication in in vitro models. IIMCB and ELECTRA will determine the crystal structure of at least one coronavirus functional proteins to evaluate the structural similarities with other viral proteins. EXSCALATE4CoV consortium  will identify safe in man drugs repurposed as 2019-nCoV antiviral and will propose to the EMA innovation task force (ITF) to define a preliminary development strategy and a proposal for a registration path. The E4C project will share promptly its scientific outcomes with the research community by using established channels: ChEMBL portal for the biochemical data, the SWISS-MODEL portal for the homology models of vir
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'In vivo fuel utilization and metabolic regulation by brown adipose tissue'.

assistant: **Innovation**

Brown adipose tissue (BAT) has a high capacity to dissipate chemical energy generated from glucose and lipids as heat, a process typically induced by cold exposure, termed thermogenesis. This process has gained significant clinical interest as a strategy against obesity and diabetes because of its potential to expend excess calories as heat. However, our understanding of BAT metabolism on an organismal level is still rudimentary, thus, to advance BAT-targeted therapies, we must first comprehensively define how BAT utilizes its key fuels, such as glucose in vivo.  It is widely assumed that the major role of glucose during thermogenesis is to provide energy for the TCA cycle and subsequent uncoupling by the key thermogenic protein in BAT, uncoupling protein 1 (UCP1). However, recent literature reveal that this assumption is oversimplified since glucose has many fates once it enters cells, feeding into additional metabolic pathways beyond the TCA cycle, which are necessary for optimum thermogenesis.  In this project, I will use state-of-the-art glucose-tracing technology that utilizes mass spectrometry, combined with classic Cre-Lox and novel CRISPR/Cas9 genome editing strategies to precisely define how thermogenic adipose tissue utilizes glucose in vivo and to delineate the role of solute carrier transporters of the SCL family, including SLC25a1, for glucose utilization and thermogenesis. SLC25a1 delivers the glucose-derived metabolite citrate across the mitochondrial membrane for use in de novo lipid synthesis, a process that are highly regulated in the BAT of cold exposed mice. This project will expand our understanding of how thermogenic adipocytes utilize glucose and will potentially reveal novel therapeutic strategies to enhance thermogenesis. My previous experience
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'INtegrated Spatial PlannIng, land use and soil management Research ActTION' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The aim of INSPIRATION is to adopt a funder and end-user demand-driven approach to establish and promote the adoption of the knowledge creation, transfer and implementation agenda for land use, land-use changes and soil management in the light of current and future societal challenges. Main objectives are: • Formulate, consult on and revise an end-user oriented strategic research agenda (SRA), • Scope out models of implementing the SRA, • Prepare a network of public and private funding institutions willing to commonly fund the execution of the SRA. INSPIRATION’s mission is to improve the supply and effectiveness of science/knowledge take-up by those who really need it. The proposed methodology is based on a multi-stakeholder, multi-national and interdisciplinary approach that covers the variety of stakeholders (public bodies, business, science, citizens and society) and the variety of relevant. The vehicle to engage with all relevant stakeholders across the Member States is a National Focal Point (NFP) in 16 countries. The NFP’s will organize workshops with national stakeholders of funders, end users and researchers across the various soil and land management disciplines. The results will be taken up, structured along four integrative themes and merging into thematic knowledge needs to satisfy the as yet unmet societal challenges and to ensure that knowledge contributes primarily to enable meeting these challenges. Based on these results a cross country and cross discipline dialogue will subsequently be organized among the relevant user communities, funding bodies and scientific communities in Europe in order to reach a trans-national, prioritized SRA as well as a model for execution of this SRA. Thus to achieve an SRA of which national funders believe that for any Euro
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Identification of the Molecular Mechanisms of non-response to Treatments, Relapses and Remission in Autoimmune, Inflammatory, and Allergic Conditions' (3TR).

assistant: **Concept**

3TR is a transdisciplinary consortium made of experts in all areas of medicine, basic sciences and bioinformatics from academic institutions, SMEs, and 8 major pharmaceutical companies, teamed to study a fundamental issue in medicine: the mechanisms of response and non-response to therapies, the major aim of 3TR, both within single disease entities and across diseases, where molecular stratification may identify shared disease taxonomies. The molecular identification of groups of patients to whom a drug will benefit, will allow focusing on those who are drug orphan. Harmonization of data from existing academy or industry-sponsored studies will identify biomarkers to inform a new collection. Specimens of diseased tissues, blood, stools, and other fluids will be obtained in a de novo observational prospective trial with standard of care medication prior, during and after first or second line of treatment. Because the studies will be at different phases of progression, a carrousel model of work was designed for input and output of data to be continuously analysed, and interpreted, to inform those measurements to be undertaken and allow cross-validation of results. The 3TR team will elucidate the role of the microbiome, genetics and regulatory genomic features in disease progression. The working aims of 3TR are: 1) establish a centralized data management platform; 2) perform comprehensive molecular and clinical characterisation of a prospective patient cohort; 3) establish integrated analysis of all data using advanced bioinformatics/statistical and modelling methods; 4) identify sets of predictive biomarkers of response/non-response to therapies; 5) improve the competitiveness of European industry and support development of novel solutions. 3TR will sustain beyond the proj