RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of circadian clock genes in the eye: a shift in scientific focus' (2002-2006).

assistant: **Concept**

The mammalian circadian system controls daily cycles in sleep, activity, and physiology, with precise synchronisation to environmental daily light cycles as its main function (entrainment). Studies in knockout mice showed that the clock genes perl, per2, c ryl, cry2 are essential to drive the mammalian circadian oscillation, but their precise role in entrainment remains unclear. Clock gene knockout mice are affected in their circadian light response. Previous work has shown that light induced behavioural pha se shifts and induction of the immediate early gene c-Fos in the central circadian pacemaker (suprachiasmatic nucleus; SCN) are affected by per and cry gene deletions. Such results are mostly interpreted as an effect caused by malfunction of the central pa cemaker. The hypothesis, however, that deletion of a clock genes is likely to affect the circadian organisation in the retina and may reduce its phototransduction efficiency has so far been overlooked. In this study, we want to separate the effect of per o r cry gene deletions on the light responses in the eye and the circadian system. Electro-retinogram, retinal c-Fos induction, SCN c-Fos induction, behavioural phase shifts will be quantified mperl''', per2~'~, perl'''!''', cryl''', cry2''', and wildtype mi ce. Differences in light responses will be correlated with the anatomy of classical and non-classical retinal photoreceptors. Aberations of rhythmicity in melatonin production and electrical activity in isolated retinas will be studied as a possible source for anatomical and light response differences. For these retinal preparations a new melatonin producing mouse model, bearing one of the clock gene deletions, will be developed. This project is not funded otherwise and although most equipment and material is
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Water Saving for Solar Concentrated Power'.

assistant: **Objectives**

Concentrating Solar Power is one of the most promising and sustainable renewable energy and is positioned to play a massive role in the future global generation mix, alongside wind, hydro and solar photovoltaic technologies. Although there is definitely perspective for the technology for rapid grow, success of CSP will ultimately rely on the ability to overcome obstacles that prevent its mass adoption, especially the large financial demand and limited accessibility of water. Water saving is therefore one of the major issues to ensure a financially competitive position of CSP plants and their sustainable implementation.To overcome such challenges, WASCOP brings together leading EU and Moroccan Institutions, Universities, and commercial SMEs and industry. They join their forces to develop a revolutionary innovation in water management of CSP plants - flexible integrated solution comprising different innovative technologies and optimized strategies for the cooling of the power-block and the cleaning of the solar field optical surfaces. WASCOP main advantage consists in the ability to reflect and adapt to the specific conditions prevailing at individual CSP plants, unlike other competitive approaches proposing a single generic solution applicable only on some referenced cases. The WASCOP holistic solution provides an effective combination of technologies allowing a significant reduction in water consumption (up to 70% - 90%) and a significant improvement in the water management of CSP plants. To demonstrate the benefits (whether economic or environmental), the developed system will be tested and validated in real conditions of four testing sites in France, Spain and Morocco after preliminary demonstration in laboratory environment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cost-effective prOdUction of ligNin plaTform chemicaLs Extending the biobaSed chemicalS portfolio' goes beyond current state-of-the-art under Horizon Europe.

assistant: **Innovation**

Europe´s ambitious sustainability and climate goals are heavily relying on the transition from fossil-based to bio-based chemical building blocks. Lignin as abundant natural resource has substantial potential to serve as starting material for the production of functionalized aromatic compounds. Only 1-2% of the lignin annual production is used in chemical conversion. Critical challenge to overcome is the heterogeneous and complex nature hampering the full exploitation of isolated lignins. To address this challenge, COUNTLESS will demonstrate the first catalytic hydrogenolysis process  operated in continuous mode at industrially relevant scale  for the cost-effective and sustainable production of lignin-based platform chemicals. COUNTLESS will demonstrate the applicability and cost-effectiveness of lignin-based platform chemicals in a variety of end-use cases from bulk to specialty applications. This project is formed by key partners covering the whole value chain including feedstock suppliers, technology development experts, well-recognized industry players in the respective application fields, experts in dissemination, communication and exploitation, and experts in integrated sustainability, environmental, and techno-economic assessments. Revenue streams will result from licensing agreements and an increase in turnover and margin for COUNTLESS suppliers and application partners. We anticipate a positive NPV and IRR in 15 years of operation. COUNTLESS contributes directly to the CBE-JU  SIRA and KPIs through the increased use of sustainably sourced biomass, reduction of GHG emissions through improvements in the pilot infrastructure (>50% reduction in GHG emissions and 85% using fully renewable supply) and the development of bio-based high-value products substituting cur
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'NANOMATERIALS-RELATED ENVIRONMENTAL POLLUTION AND HEALTH HAZARDS THROUGHOUT THEIR LIFE-CYCLE' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

The purpose of this project is to identify and rate important forms of nanotechnology-related environmental pollution and health hazards that could result from activities involved in nano-structures throughout their life-cycle, and to suggest means that might reduce or eliminate these impacts.  Besides the positive multipurpose nano-reinforcement in materials and expanded devices applications, little is known about the environmental and health risks of certain manufactured nanomaterials. Initial research has indicated that nanomaterials can have a negative impact on human health and environmental pollution. For instance, carbon nanotubes may be more toxic than other carbon particles or quartz dust when being absorbed into the lung tissue; however, specific detailed research is required. More importantly, and fundamental to the success of nanotechnology, is the perceived safety of the technology by the public.  As activity shifts from research to the development of applications, there exists an urgent need to understanding and managing the associated risks, but in particular to personnel working with these materials. To address these issues, an investigation of biological interactions of nanoscale and nanostructured materials on in vitro toxicological mechanisms is proposed. Further, an assessment of their impact on environmental pollution regarding water, soil and air is also proposed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Rise of the 3rd dimension in nanotemperature mapping' in the context of a Horizon 2020 call.

assistant: **Objectives**

The last decades witnessed a quest for devices responding to temperature at a distance with unprecedented space resolution, approaching the nanoscale. Such devices are valuable in both fundamental and applied science, from overheat in micromachines to hyperthermia applied to cells. Despite great advances, the response is still collected in 2D. In real systems, heat flows in 3 dimensions such that 2D nanothermometers give just a plane view of a 3D reality. The restriction to 2D emerges because space resolution is bound to time and temperature resolutions, leading to a trilemma: scanning into the 3rd dimension is time consuming and cannot be achieve without losing temperature and time resolutions. While incremental improvements have been achieved in recent years, adding the 3rd dimension to nanothermometry is crucial for further impact and requires an innovative approach. Herein, I propose the development of nano local probes with tailored magnetic properties recording critical information about local temperature in 3D. These thermometric local probes avoid the resolution trilemma by recording the most relevant temperature information instead of reading the present temperature value. In many applications, including cellular hyperthermia, most part of the current temperature reading is of minor relevance and can be dropped. The key temperature information includes the maximum temperature achieved, the surpass of a given temperature threshold, and the time elapsed after this surpass. Once recorded, this key information can be read in 3D by standard devices (such as confocal microscopes and magnetic resonance imaging scanners) without time constrains and thus keeping a high space and temperature resolution. Moreover, the reading step can be performed in-situ and/or ex-situ,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Analysing Transition planning and Systemic Energy Planning Tools for the implementation of the Energy Technology Information System' in the context of a Seventh Framework call.

assistant: **Objectives**

The present project aims at bringing together EU competence on a transition towards a sustainable and low carbon energy system through energy innovation, encompassing transition planning, energy modeling activities, and technology assessment. This will be achieved by creating a platform in which techniques and data are collected, shared and harmonized. The Objectives of the project are to: • Review models/tools used in the European Countries, taking in mind what is used outside Europe, and what are the requirements of the SETPlan (WP1, WP2) • Identify and recommend common tools to be used in all countries and in the Energy Technology Information System, and gain consensus on these models (WP3). • Identify and recommend existing technology databases and provide a roadmap for the development of these databases on a European and on a regional basis (WP4). • Demonstrate the ability of the recommended tools to be used for energy planning (WP5) • Identify the roadmap for the improvement and development of the tools in order to cover the needs of the SETPlan implementation (WP6). To achieve these objectives the project consortium consists of Institutions with a long experience in the fields of energy planning tools development and use. In order to ensure the direct links with the SETPlan development and requirements, the JRC, Institute of Energy will be part of the Steering Committee of the project. The final outcome of the project is expected to be a concrete list of tools, that can be used on a Member State level and on a European level which will be generally accepted, an initial set of input data for these models, and a roadmap for the development of both data and tools, in the future.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ChaperoneRegulome: Understanding cell-type-specificity of chaperone regulation' in the context of a Horizon 2020 call.

assistant: **Objectives**

Protein misfolding causes devastating health conditions such as neurodegeneration. Although the disease-causing protein is widely expressed, its misfolding occurs only in certain cell-types such as neurons. What governs the susceptibility of some tissues to misfolding is a fundamental question with biomedical relevance. Molecular chaperones help cellular proteins fold into their native conformation. Despite the generality of their function, chaperones are differentially expressed across various tissues. Moreover exposure to misfolding stress changes chaperone expression in a cell-type-dependent manner. Thus cell-type-specific regulation of chaperones is a major determinant of susceptibility to misfolding. The molecular mechanisms governing chaperone levels in different cell-types are not understood, forming the basis of this proposal. We will take a multidisciplinary approach to address two key questions: (1) How are chaperone levels co-ordinated with tissue-specific demands on protein folding? (2) How do different cell-types regulate chaperone genes when exposed to the same misfolding stress?Cellular chaperone levels and their response to misfolding stress are both driven by transcriptional changes and influenced by chromatin. The proposed work will bring the conceptual, technological and computational advances of chromatin/ transcription field to understand chaperone biology and misfolding diseases. Using in vivo mouse model and in vitro differentiation model, we will investigate molecular mechanisms that control chaperone levels in relevant tissues. Our work will provide insights into functional specialization of chaperones driven by tissue-specific folding demands. We will develop a novel and ambitious approach to assess protein-folding capacity in single cells movi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Multilevel Modelling for Predictive Toxicology' in the context of a Seventh Framework call.

assistant: **Objectives**

Computational toxicology seeks to apply modern computing and information technology, with molecular biology and chemistry to predict toxicity of chemical compounds and to improve risk assessment. Recent technological breakthroughs have made it possible to discover new mechanisms of toxic action and have opened the way for the implementation of systems biology and in silico methods in the field of toxicology. Coupling different levels of modelling will enable the integration of disparate data and will provide a powerful tool for studying various aspects of predictive toxicology.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes - an innovative research program of biobanks and expertise'.

assistant: **Objectives**

Type 1 diabetes is caused by an inflammatory process which damage insulin-producing beta-cells in the pancreas. It is one of the most common chronic diseases and its incidence is rapidly increasing. Due to its complications it causes a significant medical and economic burden to European society. A causal association between enterovirus and type 1 diabetes has become more and more likely. The aim of the present research programme is to create a new research strategy aligned to a concerted scientific research effort and creation of a network of unique resources which makes it possible to achieve a significant breakthrough in this field. The main focus is in the detection of persistent enterovirus infection leading to inflammation and tissue damage in the pancreas and its role in mediating the inflammatory response that causes type 1 diabetes. The goal is to take the critical steps towards therapeutic translation of research findings by employing a novel research design and synergistic networks of excellence based on the combination of a multidisciplinary research strategy and availability of unique biobanks existing in Europe. This research programme will also create a completely new type of biobank which facilitates a wide range of new analyses of fresh tissues. The programme includes a strong translational component which facilitates the ongoing efforts to develop vaccines against diabetogenic enteroviruses and other targeted therapies. The program also has a wider impact on the entire field of research on pathogen-disease associations, since the same innovative research strategy can be applied to other diseases as well. Altogether, this research program will take full advantage of the excellent biobank networks and a long tradition in biomedical and clinical research i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Soil Contamination: Advanced  integrated characterisation and time-lapse Monitoring' in the context of a Seventh Framework call.

assistant: **Objectives**

This project is aimed at improving current methods for monitoring contaminant distribution and biodegradation in the subsurface. Currently proven methods (based on invasive sampling of soil, soil water and gaseous phase) are unable to provide sufficiently accurate data with high enough resolution. Resulting in inability to assess of bioremediation progress and quantification of the processes involved in such bioremediation at field sites. Consequently, present assessment strategies to decide on optimal remediation approach, including design of monitoring systems, and evaluation of degradation progress, are severely flawed by uncertainty. Geophysical time-lapse measurements in combination with novel ground truthing methods give the possibility to determine: absolute contamination levels, spatial spreading, and reduced concentrations of contaminants in a heterogeneous environment. Geophysical methods of data acquisition alone are presently unable to provide absolute levels of biodegradable contamination concentrations. We aim to make improvements of fundamental constitutive relations between soil physical and degradation activity parameters and geophysically measurable parameters. Despite current improvements, there is a strong need to test these theories in practical field situations. Our project is dedicated to improving both site contamination assessment and the monitoring of bioremediation processes, and changes in soil environmental conditions. We suggest combining improved conventional soil monitoring techniques with state-of-the-art geophysical approaches. Partners in the project range from microbiologists to geophysicist, all with working experience from contaminated sites. Process studies involving lysimeters, and testing of the combination of technologies at two
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Harmful Algal Bloom species in Thin Layers' to be submitted under Sixth Framework.

assistant: **Abstract**

The project HABIT researches the development and dispersion of HAB populations in sub-surface micro-layers. It focuses on a genus of phytoplankton that has a serious impact on the economic development of the European coastal zone and which frequently occurs in sub-surface, thin micro-layers. The overall objectives of HABIT are to resolve fundamental patterns in the occurrences of Dinophysis and quantify the processes that are important in governing their distribution. To this end, the project HABIT will i) investigate the maintenance and persistence of high density thin layers through studying interactions between fine scale physical diffusion and net growth and trophic relationships within them; ii) investigate the precise role of small scale structures on the coastal shelf as incubators for accumulations of Dinophysis; and iii) utilise physical models to examine the formation and persistence of gyres on the shelf, to predict their transport, and as a consequence HAB events at the coast. A high-resolution vertical profiler will be utilised in tandem with a moored profiling system currently in use in the US for studying HAB species occurrences. Thin layers of Dinophysis will be identified. Small-scale physical processes (vertical and horizontal diffusion) will be measured, and related to net growth. Results will allow an overview of the balance between dispersion and accumulation in the layers and the time-scale of their persistence. Retention zones and other small-scale structures on the coastal shelf will be investigated as incubators for thin layers of HABs using quality physical models to model and predict the formation, persistence and movement of these structures. In this way, potential incubator sites will be shown to depend on the hydrodynamic regime of the coas