RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Finding promising drug candidates against tuberculosis with multidisciplinary protocol based non-conventional search.' (SCRIN-SILICO) under Sixth Framework.

assistant: **Objectives**

The main objective of the project is the development of a protocol capable of identifying i) novel drug binding sites and ii) novel drug-protein complexes of Mycobacterium tuberculosis proteins. Our present knowledge of human genomics and proteomics a llows possible new approaches in drug discovery, motivated by combinatorics-based data-mining and knowledge discovery techniques, sometimes labelled as high throughput" techniques. Solely these approaches (without sound biological background) seem to be still inadequate for drug discovery. In the present project we aim to develop a protocol, rather than a software with two ingredients: a, A method, with an algorithmic solution in its centre, which identifies surface indentation patterns in protein 3 D structures. Using very high throughput methods based on recent result of data mining and information retrieval, pairwise searches will be conducted to predicate drug-protein binding in two main phases, a rough first phase (Silico 1) and a more thoroug h docking investigation (Silico 2) in the second phase. b, A structural and molecular biology protocol for examining the most promising drug-protein fit pairs with a variety of medium throughput and low throughput methods."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'A novel shrouded vertical axis wind turbine for power generation in buildings'.

assistant: **Concept**

The reasoning which emerges the need for creating WindiBox is to effectively tackle the existence of limited wind turbine applicability for wind energy generation in buildings on a global scale. There is an obvious technological gap in the market, covering the exploitation of low speed air flows, especially in urban environments and areas where the dynamics of air are low and do not allow the installation of common wind turbines. According to the requirements imposed by the Energy Performance of Buildings Directive all new buildings must be nearly zero-energy by the end of 2020. All new public buildings must be nearly zero-energy by 2018. The WindiBox device is comprised of a vertical axis wind turbine, enclosed inside a box-shaped, convergent-divergent casing (diffusers). This casing has been proven to augment the rotational speed of the wind turbine by a factor of at least 2.5, compared to a stand-alone turbine and additionally, enhancing its power output by at least 3 times. WindiBox size of 1m height – 2.5m width – 4m length offers power outputs ranging from 2700-3400kWh annually for wind speed 5m/s. The casing is also utilized to act as an environmental shield for minimal noise and vibration emissions since its extended surface area can be exploited for the addition of insulation. WindiBox overcomes the technological limitations of existing solutions in the market as well as the targeted milestones for CO2 emissions imposed by the European Union. What differentiates WindiBox from the competition is that it offers an unparalleled cost-effective solution of ROI less than 4.5 years for 5m/s with exceptional performance characteristics, disrupting the existing market of renewables. Our goal is to bring the WindiBox solution to market, after preparing an elaborate busin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Molecular Mechanisms Regulating Pancreatic Islet Vascularization' (ISLETVASC).

assistant: **Innovation**

Many reports indicate the number of people with diabetes will exceed 350 million by the year 2030. Both type 1 and type 2 diabetes are characterized by the deterioration and impaired function of pancreatic b-cells. While transplantation is a promising strategy to replace lost tissue, several obstacles remain in the pathway to its clinical application. Whether b-cells are derived from patient samples or differentiated from embryonic stem cells, a major concern facing these strategies is how a recipient will respond to transplanted foreign tissue. Since the native environment for pancreatic islets is comprised of neural and vascular networks, successful integration may depend upon signals received from these neighboring cell types. Using a multidisciplinary approach, the principal investigator plans to elucidate molecular mechanisms underlying the interactions between pancreatic islet cells and their neighboring endothelial cells. Developing an understanding of how these interactions change during the pathogenesis of disease will provide insight into how islet growth and insulin release is dependent upon signals received from adjacent cell types. Emphasis will be placed on genetic mouse models to measure changes in gene expression in both isolated pancreatic b-cells and endothelial cells to identify genes that mediate the interaction between these cell types. In addition, it is of great interest to identify secreted factors that may constitute autocrine or paracrine signalling mechanisms that influence growth and function between these cell types. Furthermore, it will be determined whether current protocols for the differentiation of mouse stem cells into insulin producing cells are improved by restoring the expression of genes which facilitate communication to endothelia
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Advanced Barocaloric Systems for Sustainable Commercial Cooling Applications'.

assistant: **Concept**

Founded in 2019 in Cambridge (UK), Barocal is revolutionizing the heating and cooling industry with cutting-edge technology based on solid barocaloric materials. This innovative approach offers a low-emission alternative to traditional vapor-compression methods by utilizing barocaloric materials and applying pressure to change temperature. Barocal aims to lead the market in eco-friendly heating and cooling technologies, leveraging its scientific leadership. Committed to developing ultra-high energy efficiency, low-emission systems, Barocal’s solutions benefit customers, the industry, and the planet. The company’s solid refrigerants are safe, have zero global warming potential, and aim to reduce CO2 emissions by 75% compared to the market standard by 2026, achieving 2-3 times higher energy efficiencies. Barocal’s R&D efforts have resulted in a prototype with a high Coefficient of Performance (COP), comparable to traditional vapor compression units. Currently, the company is developing technology, targeting a temperature range of 40 degrees, and a cooling power of 1000 Watts. The prototype aims to transition commercial air-conditioning units into more efficient and cost-saving systems, featuring a modular design for wider applicability and installation. Barocal's  journey involves engineering and material science challenges, with application focus tailored through collaborations with OEM partnerships. The commercial ambitions include demonstration projects to test the units in real-life scenarios, providing crucial customer data on return on investment, and de-risking planned scale-up.


**Keywords:** Heating and cooling technologies with barocoloric material
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'PLATFORM OF GAMES FOR PEOPLE WITH CEREBRAL PALSY TO ENHANCE LIVING ADJUSTMENT' (GAME-ABLING), addressing dissemination and exploitation.

assistant: **Impact**

Cerebral Palsy (CP) is one of the most frequently conditions in childhood, with an incidence of 2 per 1,000 live births. In the EU there is 1.3 out of 15 million persons with CP in the world. This neurological disorder affects body movement, balance and posture and almost always is accompanied by other cognitive or sensory impairments like mental retardation, deafness and vision problems. The severity of these problems varies widely, from very mild and subtle to very profound.These disabilities lead to an inactive lifestyle which reduces the patient’s physical health, social participation, and quality of life. Therapy costs can be up to €45,000 by year, a cost that cannot be afforded by most of the families. Playing Video games is a useful treatment that promotes and maintains more active and healthful lifestyle in these persons. This in turn contributes to reduce medical and social care cost and improve well-being of their families. However accessibility to videogames is hardly applied for them.GAME-ABLING is to create a software tool for creating interactive video games in an intuitive manner in such a way that non-expert personnel (e.g. parents) can develop customized games. Games will be controlled using body movements and voice. To this end, Computer Vision and image processing techniques will be developed to improve accessibility.GAME-ABLING  will create a web portal to make up a disabled gaming e-community in where users will have access to use the software tool, play games and upload own creations to share it. SMEs envisage GAME-ABLING exploitation following a subscription business model to have full access to the web portal.GAME-ABLING represents a business opportunity for the SMEs, who expect to reach 0.5% world market penetration and an accumulated income of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The role of the ubiquitin-like molecule NEDD8 in nucleolar signalling' (ND8-NOS).

assistant: **Concept**

Ubiquitin and ubiquitin-like molecules (Ubls) such as SUMO and NEDD8 regulate myriad of biological processes. NEDD8 was discovered as one of 10 genes that are down regulated in mice brains during development. Amongst the family of Ubls, NEDD8 has the highest homology and identity to ubiquitin, but a distinct conjugation pathway exists that leads to the covalent conjugation of NEDD8 to substrate proteins. Genetic experiments in plants, S. pombe, Drosophila, C. elegans, and mice, have demonstrated a vital role for NEDD8 in cell growth, viability and development. However, compared to ubiquitination or SUMO conjugation much less is known about molecular targets and pathways controlled by NEDD8.We established proteomic methods to identify NEDDylated proteins, which showed that the NEDD8 proteome is more diverse than previously thought. Following on the proteomic studies we discovered a new role for NEDD8 in controlling the function of the nucleolus as a sensor of perturbations in cell growth. Additional proteomic studies defined the molecular changes in the nucleolar proteome caused by inhibition of NEDDylation, establishing the nucleolus as key target for the NEDD8 pathway. Recently, we developed a genetic model system (C. elegans) for components of the NEDD8 machinery. Our goal is to capitalize on these discoveries and further develop an internationally competitive research program in: The role of NEDD8 in controlling the nucleolus and to establish genetic model systems for nucleolar signalling.As inhibitors of NEDDylation are in clinical trials for the treatment of cancer, we believe our studies will also identify targets and mechanisms for the action of these potential chemotherapeutics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Phenotypic heterogeneity in Bacillus subtilis biofilms' under Seventh Framework.

assistant: **Concept**

Biofilms are environmentally relevant lifestyles of microorganisms. Biofilms are usually isolated from surfaces or interfaces, where cells grow together, differentiate, produce a matrix and communicate through the matrix. This matrix also protects them from environmental insults, such as antimicrobials and several other stress conditions. Biofilms possess high complexity that is changing in time and space. To achieve such a differentiation cells enter various phenotypic pathways. Several studies present example how phenotypic heterogeneity (subpopulation of cells harbouring same genotype but expressing different sets of genes therefore showing diverged phenotype) plays a role during the development of biofilms. However, most of these studies concentrate on the genes coding for enzymes involved in the production of the biofilm matrix. Therefore studies that concentrate on the genes and regulation of genes that are involved in development of biofilm structures are desired. In this proposal, I will concentrate on the interplay between different cell types present in the biofilm and the role of heterogeneity in the development of biofilm structures and maturation. This proposal aims to unravel how the structure development is modulated in B. subtilis biofilms, what is the role of the cell growth strategies, the cell-cell communication, local cell level environment and gene expression in biofilm formation.The main objectives include (1) the development of an experimental system for bacterial biofilms, where heterogeneity in metabolic status of the cells can be followed; (2) the generation of a novel theoretical model for B. subtilis biofilms; (3) the isolation of growth yield favouring phenotypes; (4) detection of heterologously expressed transcripts at the single cell level
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'An innovative and sustainable process for reducing the environmental impact of stainless steel production, enabling impressive recovery rates and cost savings.' (REGMAX) targeting Horizon 2020.

assistant: **Abstract**

Pickling is a metal surface treatment used in the stainless steel industry to remove impurities from steel and obtain optimalservices. Every hour, approximately 300,000 litres of acid are used in pickling, resulting in huge quantities of waste acid.Alongside the damaging environmental impact, steel pickling works suffer from high operational costs to manage thedisposal or regeneration of said acid. SUSTEC has developed the REGMAX system, a new acid regeneration process toprovide a sustainable low-cost solution to this problem. The REGMAX system increases acid regeneration rate to over 97%and reduces operational costs by up to 91%. Within the overall project, SUSTEC intends to scale-up regeneration capacity;and commission a pilot plant for a large scale demonstration and validation of the technology in industrial conditions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Genetic and epigenetic signature of transcription termination', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Most eukaryotic genes are transcribed by RNA polymerase II (Pol II) in a cycle of initiation, elongation and termination. Transcription termination, defined as the cessation of RNA synthesis and release of Pol II from its DNA template, depends on a functional poly(A) sequence as well as downstream terminator sequences. Correct termination is important for the prevention of transcriptional interference, efficient protein production and Pol II recycling. Further on, aberrant poly(A) usage and alterations of 3' UTR length have been functionally linked to cancer.Despite its vital importance, transcription termination mechanisms have only been studied on a handful of genes, and the general principles ruling this process are unknown. In particular, the influence of the chromatin context on Pol II termination is an enigma.The objective of this proposal is to elucidate the genetic and epigenetic signature of transcription termination genome-wide using a combination of computational, genetic and biochemical approaches. First, a systematic in silico screening will be performed for chromatin modifications and transcription factors' occupancy, as well as DNA sequence elements in putative terminator regions. It will be based on the model genes and their termination pathways dissected in the host lab, as well as a wide range of publicly available and self-generated genome-wide data sets of chromatin-associated features. This unbiased screening will yield the first insight into the genome-wide characteristics (signature) of terminator elements, allowing for subsequent functional studies using hypothesis-driven experimental  approaches.The implementation of this proposal will strongly enhance the researcher's competence by training in the field of RNA processing, complementary to her b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Operating ICT basic switches below the Landauer limit' (LANDAUER) targeting Seventh Framework.

assistant: **Abstract**

The scientific objective of this project is to test the fundamental limits in energy dissipation during the operation of physical switches representing the basic elements of logic gates. We address the physical limits arising from a generic switch mechanism that is common to any digital device, with specific reference to the fundamental limit arising from the decrease of information in the computation procedure, also known as Landauer limit.The technological objective of this project is to introduce new conceptual devices that, through novel computing paradigms with radically improved efficiency, are capable of trading the minimum amount of energy dissipated with the computational precision.In order to reach such objectives in a joint effort, the LANDAUER consortium composed by world leading experts in nanoscale energy management will fabricate, test and evaluate three classes of new conceptual devices: magnetic switching nanoparticles", "nanomechanical switches" and "nanoelectronic stochastic logic gates" addressing applied prototypes for computing tasks in the presence of noisy operating conditions."
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FCAECC Fellowship programme for talented researchers in cancer' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

The Scientific Foundation of the Spanish Association against Cancer (from now on, FCAECC) is a philanthropic private entity that aims to finance excellent cancer research in Spain for the benefit of the general public and patients. Ranging from basic research to clinical application, FCAECC is the entity that devotes the most funds to promote and support cancer research in Spain. In its Strategic Plan, FCAECC states its firm commitment to finance the best cancer research in Spain, aiming at promoting talent, stabilizing the professional career of researchers, fostering the globalization of Spanish cancer research and involving society. FCAECC has a national fellowship programme that supports experienced researchers to develop their own research lines and currently is funding 525 cancer research projects worth 92 million EUR, which resulted in 316 publications in 2021, with an average impact factor of 8.With AECC Talent new fellowship programme, FCAECC opens its fellowship programme for trans-national mobility, aiming to attract to Spain the most talented experienced researchers from abroad. AECC Talent will contribute to improve prevention, early diagnosis, monitoring and treatment of cancer patients, which are key intervention areas of the Horizon Europe Mission on Cancer. AECC Talent will fund 30 fellowships divided into two calls.Host organisations participating in the programme are accredited by FCAECC as excellent in cancer research by means of a rigorous assessment process that guarantees their quality, impact and leadership in cancer research at national and international level. Fellows will have a wide choice of entities and multidisciplinary teams in which to carry out the project of their interest, following a bottom-up approach. The 15 host organisations repo