RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Economic Fluctuations, Productivity Growth and Stabilization Policies: A Keynesian Growth Perspective', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

The macroeconomic literature has traditionally separated the study of business cycles from the analysis of long-run productivity growth. Yet, the interactions between economic fluctuations, productivity growth and stabilization policies are well present in the policy debate, especially since the start of the Great Recession. In this proposal, I will develop a Keynesian growth framework to study business cycles and growth in a unified theory. The framework combines the Keynesian insight that fluctuations might be driven by changes in aggregate demand, with the notion, developed by the endogenous growth literature, that productivity growth is the result of firms’ investment in innovation.In part I, I will develop a novel Keynesian growth model with heterogeneous firms, in the spirit of the state-of-the-art quantitative endogenous growth literature. I will use the framework to study the impact of monetary and fiscal policy on productivity growth; to understand the behavior of productivity during large recessions triggered by financial crises, such as the recent Great Recession; and to investigate the possibility that pessimistic expectations might give rise to periods of stagnation.In part II, I will provide an open economy Keynesian growth model, able to capture the interactions between monetary policy, capital flows and productivity growth. I will use the framework to explain why the inception of the euro was associated with a sharp increase in capital flows across its member countries, and with stagnant productivity growth in countries recipients of capital inflows.In part III, I will test the hypothesis, at the heart of the Keynesian growth framework, that productivity growth responds to business cycle fluctuations and to monetary and fiscal policy interventions. To th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Computational modelling of the human brain lipidome' (HumBrain).

assistant: **Innovation**

The blood-brain barrier (BBB) is a complex interface that separates the central nervous system (CNS) from the circulatory system and serves to maintain brain homeostasis. There are native P-glycoprotein (P-gp) transporters embedded in the BBB endothelial cell membranes, which play a fundamental role in effluxing out xenobiotics. Such protections come at a steep price, since the BBB is a key roadblock in the delivery of treatments for CNS disorder, including brain tumors and Alzheimer’s, while the P-glycoprotein transporter reduces the effectiveness of chemotherapeutics and is responsible for the development of multidrug resistance (MDR). The HumBrain project will build the first atomistic model of a human P-gp pump embedded in a realistic model of the BBB membrane, and use molecular dynamics simulations in combination with novel free-energy techniques to provide a mechanism for the modulation of the P-gp pump by substrates and inhibitors, in order to address the origins of multidrug resistance and the origins of the high selectivity of the BBB membranes to molecules. This will be complemented by coarse-grained models to address the issue of protein-lipid modulation and alternative ways to turn off the P-gp. The models will be of sufficiently realistic representation to serve as a starting point for translational research to aid in the experimental development of the next generation CNS modulators and targets.The HumBrain project will be carried out by an experienced researcher who worked on membrane proteins during his PhD thesis in the UK and the BBB during his postdoc in the USA in conjunction with an experimental laboratory. The experienced researcher will work with a supervisor in Denmark who has a strong background in modelling complex membranes, including neuronal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'DEMONSTRATION OF THE USE OF THE NOVEL STENZEL RADIAL-IMPULSE TURBINE" IN TWO MINI HYDRO PLANTS"' to be submitted under Fourth Framework.

assistant: **Abstract**

The proposed demonstration project is to accomplish the practical application of the technical know-how at two different locations with different parameters.Both sites are to be made accessible for reference and inspection of potential plant operators in order to facilitate first time installations or change-over to this more efficient and more cost effective turbine technology.Furthermore, the measurements and test results (effectiveness, output curves, etc.) that were collected using test prototypes are to be confirmed in field tests.Also, with the support program referred to the Test Fushs GmbH wishes to expand its area of activity into hydraulic flow engines. Servosan GmbH is planning the production of a series of turbines in the future.At last the demonstration proposal is designed to secure the drinking water supply for the municipality of Freiding (watersupply Surgruppe Teisendorf/ Bavaria) and to use the considerable energy potential by means of a parallel-circuit power plant based on the free fall height of 135m and an average spring water discharge of approx. 10 l/s.The proposed project should demonstrate above all that small power plants can make use of energy in a much more cost-efficient manner. This is to be accomplished through lower production cost at similar output when compared with familiar turbines (Pelton, Francis, Kaplan). Also the additional use as a drinking water plant can be assured.Furthermore the Test-Fuchs GmbH should start a production of a series of turbines in the end, and for the Consortium for Water Supply of the Surgruppe the demonstration proposal should lead, in addition to its main purpose (the production of drinking water), to the production of cost effective and environment-friendly electric power and will be amortised within a fe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Evaluation of sustainability: European conferences and training courses EASY-ECO 2008-2010""' (2002-2006).

assistant: **Concept**

[EASY-ECO 2008-2010] is a training and conference programme on evaluations in the specific context of sustainable development. Sustainability evaluations are important for Europe because they support decision-making processes by highlighting strengths and weaknesses of particular policies, programmes and projects, they make policies more transparent and accountable and they support organisational learning. By building on the vast experience of the coordinator of the preceding EASY-ECO projects (FP5 and FP 6), this proposal combines continuity and innovation in a well balanced way. [EASY-ECO 2008-2010] consists of two scientific conferences, six virtual training courses on theoretical issues and six hand-on training courses on-site. The virtual part will operate on an e-learning Internet platform for a period of three months, hosted and moderated by the coordinator. Experienced trainers currently involved in EASY-ECO 2005-2007 will develop the training material for the e-learning platform.The on-site case trainings provide hands-on experience with actual evaluation projects. Experienced evaluators will guide the participants through the different steps of an evaluation. The two conferences support the training courses by giving young researchers the chance to present their own research to a broad scientific audience, and by bringing them in touch with a broad range of leading experts. The conferences provide the opportunity to select cutting-edge case studies for the training courses that match with recent societal and political trends. Over the last years, EASY-ECO has become a close-knit network of academics and practitioners within Europe and an academic focal point of sustainability evaluations worldwide. By developing the format of the series of events further, by i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Single-molecule visualisation of eukaryotic DNA replication termination to uncover novel mechanisms of replication stress' (SinMolTermination).

assistant: **Innovation**

Replication-stress is a key driving force of cancer development, neurodegeneration and ageing. Many sources of replication stress associated with the initiation and elongation phases of DNA replication have been discovered. In contrast, little is known about the mechanisms of replication termination and termination-associated replication stress. Recent breakthroughs identified the first elements of a mechanism of replication termination that involved ubiquitination of the Mcm7 subunit of the CMG helicase. However, we do not know how terminating replisomes signal themselves for ubiquitination, nor how this is regulated both temporally and spatially along chromatin. By combining sophisticated single-molecule imaging techniques with the ability of Xenopus extracts to replicate DNA in a physiological manner, we will for the first time, be able to watch individual replication forks terminate. Importantly, our multidisciplinary and single-molecule approach will allow us to bypass the constraints posed by ensemble techniques that have hindered progress in this field. Specifically, we will define the spatial and temporal conditions upon which Mcm7 becomes ubiquitinated and how this is connected to the fate of the CMG helicase during termination. These observations will enable us to determine a complete mechanistic understanding of vertebrate replication termination for the first time. We will also discover how failed DNA replication termination triggers replication stress. Revealing these novel mechanisms of replication stress allows for new therapeutic targets to be identified and potentially facilitates new disease prevention strategies to be recognised.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Single Photons from Isotopically-pure Rubidium Atoms in a Long fibre' (SPIRAL) under Horizon 2020.

assistant: **Objectives**

Single photon sources are essential for applications of quantum optics. For optical quantum computing the process is probabilistic and so the larger the number of photons the less time required for success. Therefore, there has been a push to increase the brightness of single photons sources. This goal of this action is to develop a source of heralded single photons with a very high spectral brightness, based on four-wave mixing in an alkali-vapour contained in a hollow core photoniccrystal fibre. This will exploit the higher efficiency expected from using a hollow core fibre to boost the brightness of the single-photon source. Also, by using optical fibre technology, this photon source should be very simple to integrate into other systems. Once the photon pairs are generated, the major challenge of this system will be to split them from themselves, as well as removing the vast number of remaining pump photons. Since all three wavelengths of the light emerging from thefibre are very close to each other, and the beams are spatially overlapped, many common techniques (such as using interference filters and/or spatial filtering) will not work. However, we have identified a scheme using an atomic Faraday filter which will allow a beam splitter to be formed for the photon pairs, whilst simultaneously removing the pump photons.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Dynamically controlling the properties of complex materials with light'.

assistant: **Innovation**

This project will use short pulses of light to understand, manipulate and control the properties of complex materials on nanometre lengthscales and femtosecond timescales. Complex materials have strongly coupled electronic, lattice and magnetic subsystems. This coupling makes the material properties difficult to explain with conventional theoretical techniques, but is responsible for the exotic phenomena that are observed, such as high temperature superconductivity. One method to unravel these interactions is to use ultrafast optical pulses to excite one, typically the electronic, subsystem on a timescale much faster than it couples to other components. This allows the energy flow through the system to be monitored in order to ascertain which parameters are most strongly coupled. In addition, exciting a specific subsystem can also lead to new and interesting properties to emerge. This demonstrates new ways to manipulate, dynamically, the properties of complex materials by light to access new phenomena. However, how these properties emerge still remains largely unknown.My research will address the questions surrounding this issue by attempting to answer, how these properties form and interact from the initial state, how these properties can be manipulated by different excitation mechanism, what properties can be induced and what do they tell us about the properties that define the underlying system? The project will look at both temporal and spatial dynamics to understand how correlations and interactions spread spatially and dynamically through an evolving system. These experiments will require combining a range of microscopic, spectroscopic and femtoscopic techniques in a new and innovative way, ranging from lab based experiments to the use of worldwide user facilities
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Elucidating the water photo-oxidation mechanism by infrared spectroscopy', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Hydrogen is a highly versatile fuel that is believed to become one of the key pillars to support our future energy infrastructure. A clean and renewable method to produce hydrogen is to use sunlight to convert water into hydrogen in a photoelectrochemical (PEC) cell. The exact mechanism of this photocatalytic water splitting remains a largely unexplored area. In this project, I will provide insight into the more challenging oxidative half-reaction occurring at metal-oxide surfaces.To gain insight into the oxidative half-reaction, surface groups residing at the solid/liquid interface will be measured by infrared spectroscopy during actual device operation. Hereto, a PEC cell will be constructed with a multiple internal reflection element as key component; it will ensure a high sensitivity while simultanously act as substrate for the working electrode. The novel approach to apply a bias voltage allows for photoelectrochemical analysis, but also allows ‘freezing’ of the surface species thereby relaxing the constraints of a fast measurement speed.From in operando measurements the density and nature of surface groups present at a well-defined metal-oxide surface will be obtained as a function of electrolyte pH. With this knowledge conclusions can be drawn on which surface sites initiate the oxidation reaction, which groups present sites where (intermediate) reactions with high activation energies take place, and where undesired hole-trapping and electron-hole recombination are most likely to occur. Thereby providing fundamental insight into the water oxidation mechanism, which is required to engineer a photoelectrode material with high photocurrents and low onset potentials. Additionally, the quantified information on surface species densities is much-needed input in models
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Cold plasma cures chronic wounds: a sparkling solution'.

assistant: **Objectives**

Plasmacure has been established in 2014 and currently employs 12 people. We have our own test facilities and technical staff. In 2018, we have received an A-round Investment of €2.2 million. Our mission statement is: We envision a world where people no longer suffer from chronic wounds. In Europe, > 3 million people suffer from this condition. Chronic wounds cause pain, lead to amputations and loss of independence. Average costs are € 12,000 per wound. Currently, 25% of these wounds persist for months or even years. We have developed a medical device (PLASOMA) based on atmospheric cold plasma, which is air that contains highly reactive particles that kill bacteria and stimulate wound healing. It consists of disposable plasma pads and a pulser that emits high voltage pulses to induce the plasma. PLASOMA is the first cold plasma device with demonstrated clinical efficacy: In a first clinical study we showed that PLASOMA can cure at least half of the wounds that currently cannot be cured. PLASOMA increases quality of life, relieves the healthcare workforce and reduces antibiotics use. Should all hard-to-heal wounds be treated with PLASOMA, EU health care costs will decrease with > € 6 billion/yr. We expect to get CE in Q1 2020, after which sales will start.With the grant we will conduct a multinational clinical study to generate clinical efficacy data with which we can extend our first CE claim (reduce microbial load) to the claim that PLASOMA can cure chronic wounds, apply for reimbursement and get PLASOMA incorporated in the treatment guidelines. We will also develop pads with different sizes and shapes and make the pulser suitable for home use such that we can cover almost the entire wound market. With the equity, we can launch PLASOMA in 4 EU countries. We expect break
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Developing indicators of environmental performance of the common fisheries policy' in the context of a Sixth Framework call.

assistant: **Objectives**

Indicators can be valuable tools for tracking change, identifying problems and monitoring implementation of policies and results. They are increasingly used to assess the efficacy of EU policies. A robust set of informative indicators will help policy- and decision-makers to evaluate the performance of management measures, as well as ensure accountability to the public through regular information. The aim of the co-ordination action is to achieve a more coherent approach to indicator use in the implementation of the Common Fisheries Policy across the EU, by synthesising existing research and analysis. A set of indicators to measure the effectiveness of fisheries management, particularly environmental aspects, is to be identified. Operational models establishing the relationship between fishing activities and changes in the marine environment will be used to underpin some of the ecological indicators. In addition, the project will identify data gaps and ways of addressing these, taking account of the need for cost- effectiveness. The project will also seek ways of ensuring that agreed indicators are used in the policy process. The results will be targeted at fisheries managers and other stakeholders. Overall, the action is firmly embedded in, and will respond directly to, EU policy calling for the development of fisheries/environment indicators. A number of work packages will examine existing efforts to develop indicators. Since a considerable amount of work has been done already, networking will be of particular importance. In order to bring expertise in different countries together, several meetings and two conferences will be held. As the combined scientific and policy expertise of the participants covers both fisheries and environmental issues, the CA will be a vital