RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Quantum simulations with trapped Rydberg ions' under Seventh Framework.

assistant: **Concept**

This project focuses on the realization and application of trapped Rydberg ions for quantum information processing and quantum simulation. It will bring together two prospective quantum computational systems: trapped ions and Rydberg atoms. Joining them will form a novel quantum system with advantages from both sides.This approach will open a new path of investigation for quantum computing and simulation and will allow investigation of different physical qualities not yet addressed in the existing systems. In particular, it promises to speed up entangling interactions by three orders of magnitude and to extend the interaction distance by at least a factor of two between neighbouring ions. The higher speed of entangling interactions would allow the execution of more complex quantum algorithms before decoherence destroys the stored quantum information. The increased coupling distance would enable the controlled interaction of neighbouring ions which are trapped individually.  This would allow setting up a quantum computational system formed by a Coulomb crystal or a two-dimensional array of individually trapped ions.Such qualities make trapped Rydberg ions a powerful alternative approach for scalable quantum information processing. In particular, a string, crystal or two-dimensional array of interacting trapped Rydberg ions can be used for simulations of complex quantum systems intractable by classical computers.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Closed-loop deep learning in early-stage drug discovery - cloud platform for targeted protein degradation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Celeris Therapeutics is a deep learning company that uses innovative, in-silico methods such as geometric deep learning and graph neural networks to degrade currently undruggable targets (pathogenic proteins). The platform shall make a broad impact by addressing currently incureable diseases such as Alzheimer's, Parkinson's, and different types of cancer like breast and prostate cancer.Celeris Therapeutics' technical solution is the web application (orchestration platform) Celeris One. It consists of three modules: Hades (target ID), Xanthos (predicting biomolecular interactions and ligand design), Hephaistos (automated synthesize and validate). The addressed market is in the early-stage drug discovery and users are pharmaceutical and biotech companies with a focus on Targeted Protein Degradation. The targeted customers are med. and comp. chemists, that currently rely on docking, which is computationally intensive, slow and inaccurate compared to CelerisTx deep learning methods.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Stem Cell Cocooning for Targeted Cardiac Cell Therapy'.

assistant: **Objectives**

Stem cell therapy is believed to be the most viable method for restoration of cardiac function after Myocardial Infarction (MI), the leading cause of death in Europe. Despite numerous attempts at injecting stem cells into post-MI heart to affect regeneration, the consensus is that anoikis (cell death) induced by the lack of contact between the cells and the tissue scaffold during injection, the harsh environment at the injection site, and powerful myocardial contractions cause massive cell loss rendering the therapy ineffective. The goal of this project is to enhance treatment efficacy by individual cocooning of bone marrow stem cells in bioengineered collagen-based microspheres. The cocoon provides the tissue support for cell survival, promotes integrin upregulation for better engraftment of the cells onto the heart tissue, and protect the cells from the harsh post-MI environment. The spheres will be grafted with recognition moieties for the infarct areas, e.g. NGR peptide to enhance targeting. They will also contain growth factor VEGF to promote re-vascularization of ischaemic areas, and gold-coated silicon nanoparticles for in vivo tracking. The cocooned cells will be tested in vitro for their safety and efficacy (e.g. spheres degradation rate, cytotoxicity), and in vivo in MI mice models for their effectiveness in restoring heart functions by echocardiography, and for their traceability by dual-energy CT. As a Canadian researcher, I already joined the Liedberg group at Linkoping University, Sweden, in March 2011 as an Assistant Professor on a temporary, short-term basis to establish this project. My expertise in biomaterials and cell encapsulation combined with peptide, nanoparticle, and imaging expertise of the host laboratory are an excellent match for the success
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Meiotic adaptation to allopolyploidy'.

assistant: **Concept**

Hybridization between related species resulting in allopolyploidy is ubiquitous in the evolutionary history of plants. Such nascent allopolyploids face the challenge of ensuring accurate chromosome segregation during meiosis in the presence of related, but non-identical chromosome sets (called homoeologues), inherited from the allopolyploids progenitors. Essential for fertility, this relies upon the formation of physical connections (crossovers) between homologous chromosomes, while crossovers between homoeologues - that could lead to aneuploidy - must be prevented. Meiotic stability in the allopolyploid context thus requires a tight control of recombination partner choice. The existence of highly fertile natural allopolyploids shows that solutions exist and have arisen many times during evolution, but the mechanisms involved remain poorly understood. My goal is to elucidate the evolutionary processes of meiotic stabilization of nascent allopolyploids, with a special emphasis on the molecular mechanisms that prevent recombination between homoeologous chromosomes. I propose to recreate in the lab the natural hybridization that happened ~16 Kya between A. thaliana and A. arenosa leading to Arabidopsis suecica in order to characterize the mechanisms underlying the evolution of the young allopolyploids over the first generations as they acquire meiotic stability and full fertility. The proposed project has three main objectives: (1) map and characterize genome-wide recombination between homoeologues; (2) identify the factors that control homoeologous pairing and recombination and (3) elucidate how this control is progressively set up in newly formed allopolyploids. Our studies have the potential to bring new and fundamental insights on the evolutionary processes enabling me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'The chemical trail in protostars: From the deeply embedded phase to the planet forming disk' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The emergence of Life relied on the presence of key molecules like water and prebiotic molecules. The primitive objects of our Solar System (comets, asteroids), which formed in the disk of dust and gas surrounding the young Sun, are thought to have delivered them to Earth during heavy bombardments. Observations show that the deeply embedded Class 0 protostars also harbour a very rich chemistry in their inner regions. What occurs to the chemical composition between this early stage of the star formation process and the formation of planets, comets, and asteroids is unknown. Do the molecules detected in these young protostars survive or are they destroyed and reformed at a later stage before being incorporated into planets, comets, and asteroids?This ERC project aims to reconstruct the physico-chemical evolution from the deeply embedded protostellar stage to the planet forming disk stage, through multi-source analyses of high angular resolution observations combined with chemical modeling studies.I will investigate the evolution of complex organic chemistry and isotopic fractionation during the star formation process using interferometric observations (ALMA, NOEMA) of solar-type protostars. In addition, I will carry out numerical simulations with a state-of-the-art gas-grain chemistry code in order to interpret the observations as well as to characterize the impact of the physical conditions and their evolution (environment, grain growth and dust settling, episodic accretion) on the chemistry.This ERC project will lead to a new understanding of the evolution of the chemical composition from the earliest protostellar stage to the formation of the disk that will give birth to the planets, comets, and asteroids, while identifying the processes affecting the final composition
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Modeling the European power sector evolution: low-carbon generation technologies (renewables, CCS, nuclear), the electric infrastructure and their role in the EU leadership in climate policy' under Horizon 2020.

assistant: **Concept**

The reduction of greenhouse gas emissions is a vital target for the coming decades. From a technology perspective, powergeneration is the largest responsible for CO2 emissions, therefore great mitigation efforts will be required in this area. Froma policy perspective, it is common opinion that the European Union is and will remain leader in implementing clean policies.Basing on these considerations, the power sector and the European Union will be the two key actors of this project. Themain tool adopted in this work will be WITCH, the integrated assessment model developed at Fondazione Eni Enrico Mattei(FEEM).The description of the power generation sector in WITCH is quite detailed, but needs to be integrated, especially as far asthe electric infrastructure downstream the power generation system is concerned. In the first half of the project, developed atthe outgoing host, the modeling of the electric sector will thus be completed and refined. In particular, four main aspectsneed to be assessed: i) system integration (i.e. the issues related to the non-negligible penetration of intermittent renewablesin the grid), ii) electricity storage, iii) electrical grid, and iv) electricity trade.In the second half of the project, developed at the return host, the improved WITCH model will be employed in scenarioassessment calculations. Firstly, the prospects in Europe of renewables, CCS and nuclear will be analysed. In particular,attention will be focused not so much on the pure technology aspects, but rather on policy issues such as the role ofincentives in renewable diffusion, the slow CCS deployment, or the effects of the nuclear reactors ageing, or of their phaseout.Secondly, the focus will move on assessing the role of these technologies (and the consequent evolution of the e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'New Employment through Innovative Tools and Services for an Efficient/Effective European Structural Funds Management' (EMPLOY), addressing dissemination and exploitation.

assistant: **Impact**

The serious employment situation of 20 million unemployed is a central concern of the European Union, as indicated by the employment title in the Amsterdam Treaty. The European Structural Funds (EUSF) process, involving local, regional, national administrations and the EU, with a budget of 286.4 billion Euro for the period 2000-2006, is playing an important role in promoting employment, by providing support for medium and long-term job-creation and improving the match between physical and human resources and the operation of the labour market. However, the lack of administration efficiency (with most Member State's Structural Funds expenditures lagging behind mainly due to the existence of complex, Byzantine procedures and a highly fragmented organisation) and efficacy (no clear picture of results achieved, especially the number of jobs created) is resulting in serious deficiencies and delays in the deployment of the funded actions. As a result, collaboration and co-operation between different level of administrations to provide an efficient and effective EUSF process as well as seamless services to SMEs and individuals is becoming more than compulsory.OBJECTIVESThe main aim of EMPLOY is to develop innovative, multimedia and integrated Tools and Services designed to support the Management of the European Structural Funds (EUSF) process, involving local, regional, national and EU administrations as well as SMEs and citizens as the final recipients.Indeed, a more efficient/effective EUSF process is considered essential to create new job opportunities and reduce unemployment. As a consequence, the entire process will be revised (from proposal/funding, to funds provision and monitoring of funds usage) and all relevant actors included with the main objectives being to produc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Sixth Framework proposal on 'Towards a new generation of healthier and tastier ready-to-eat meals with fresh ingredients'.

assistant: **Concept**

The double fresh project aims to raise ready-to-eat meals to a higher quality level. In accordance with the demand of consumers, meals will be improved along with the following dimensions: more appealing, fresher (shelf life), tastier and healthier (special focus on obesity), and guaranteed safe. The meals will have an improved level of viability for the food industries. Two types of meal concepts will be developed: double fresh and freshly cooked.The double fresh meal is composed of fresh meat / fish, fresh vegetables, a pre-cooked starch component (potatoes, rice or pasta) and sauce. This meal can conveniently be heated in a microwave oven. In order to implement this meal in all European markets the shelf life needs to be extended from currently 5 days to at least 9 days (for densely populated markets within the EU) or 14 days (for most of the EU markets). The challenge will be to reach the shelf life extension without compromising on the food quality, nutritional quality and food safety.The freshly cooked meal is a cooked and packed meal that will be improved significantly compared to the current post-pasteurised meals by using either milder post-pasteurisation treatments or advanced packaging solutions. The challenge will be to achieve a more appealing cooked meal, which looks and smells fresher and tastier, without compromising on food safety and nutritional quality.Within the double fresh project a large group of scientists and industries will closely co-operate. The consortium is composed of 1 retailer, 8 food companies, 4 technology providers, 5 research institutes and 3 universities. SME???s are well represented in this strong consortium: 7 out of 13 companies are SME???s. The following scientific disciplines will closely collaborate in the double fresh project
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Solid-State Multi-Photon Sources for Larger-Scale Quantum Optics and Photonics' (SMuPhoS).

assistant: **Concept**

Optical quantum technologies are at the forefront of a forthcoming second quantum revolution, where advances in quantum photonics at the single-photon level are enabling new technologies at accelerating pace: from applications for secure quantum communication, to the realization of quantum simulation and quantum computation protocols. The scaling of quantum photonics, however, has long been restrained by low efficiencies in current photon sources, what limits the complexity of the protocols that are being demonstrated. The host team has very recently succeeded in the fabrication of solid-state single-photon sources about 20 times more efficient than current alternatives. These sources have reached the best possible performance in terms of purity and indistinguishability, as required for scalable applications. In this proposal, the high performance of these devices is combined with the expertise in quantum optics of the applicant to advance the state-of-the-art in quantum photonics to the efficient and high-rate manipulation of multiple single-photons. A new era of larger-scale quantum photonics will be attained by enabling the manipulation of multiple photons past the qubyte threshold of 8 photons. The project will include the demonstration of 10-photon sources with sub-Hertz detection rates; the implementation of heralded entangling gates run at unprecedented rates; as well as the demonstration of multi-photon interference with up to 8-photons in a Boson Sampling machine. This project will thus importantly advance upon the complexity of current multi-photon research, opening a new era of solid-state based quantum optics and photonics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'THE NANO EYE DEVICE' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The project, named NED (Nano Eye Device), hereinafter referred as “NED”, aims at developing a fully automated, small size, lightweight, self-powered and portable optical system for imaging at micro/nano dimensional range, with a field of view between 0,5 millimeters down to a pixel size of 50 nanometers. NED is automated in XYZ axis movement and has a two-way (input/output) interface, via LAN connectivity (USB backup connection anyway available), with any portable (and/or desktop) device, like tablets, smartphones, HDMI TVs screens and PCs. Traditional optical microscopes aren’t able to operate at nanometric level, so NED can operate in the area between low cost traditional microscopes and bigger, more costly and very sophisticated laser microscopes. Thanks to an innovative patented optical-laser coupling, NED will be able to record pictures and videos even at nanoparticles size level, from any biological (and non biological) sample put on a standard microscope glass coverslip. So it can be profitable used with optical biosensor for virus detection. The captured data will be then made available in real-time to any external imaging device over any TCP/IP data network, locally and remotely (live imaging). Thanks to its internal micro-computer, NED is a powerful portable device, thus representing a key enabling technology (KET) for anyone working on clinical microscopy and optical biosensors, for example thanks to the possibility to quickly and easily display specific parameters. NED’s flexible and simplified design also offers the possibility to adapt its micro and nanometric visualization capabilities to several different industry and market applications, including on-line monitoring of biological processes, pharmaceutical sector, micro-nanocode based counterfeiting appl