RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Shaping Healthy Immune Early Life Dynamics: role of the virome in undernutrition' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Nearly half of all deaths in children under five are linked to undernutrition, which causes developmental issues and increased susceptibility to infections and intestinal inflammation that are not fully corrected by traditional nutrition strategies. Early exposure to commensal bacteria shapes immune trajectories, influencing susceptibility to infections and inflammatory diseases both early in life and in the long-term. Reseach from the host laboratory has demonstrated that commensal bacteria contribute to host development, particularly under conditions of undernutrition. Similarly, commensal viruses (aka the virome) can modulate immune responses. Infants, especially in regions with high rates of undernutrition, are highly exposed to these viruses. However, the virome’s impact on immune development and its contribution to the effects of undernutrition remains largely unexplored. Building on my experience working with a commensal murine enteric virus, I aim to investigate how early immune imprinting by the virome alters host-development trajectories —including growth, metabolism, and sexual maturation—and affects long-term susceptibility to infections and inflammatory diseases in male and female mice. Using a combined approached of hypothesis-driven research (focusing on the homeostatic role of type I interferons) and a RNA sequencing-based discovery, this study will uncover unknown physiological functions of immune cells that are critical in challenging environments like undernutrition. The findings from this study will provide new insights into how understudied factors—such as the virome, sex, and undernutrition—affect immune function, including host-defenses and physiological functions. This knowledge could lead to innovative preventive and therapeutic strategies for u
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Revolutionary electric plane technology that can be used for new build aircraft as well as to convert existing non-electric turboprops into fully electric aircraft.' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Aviation traffic in Europe is projected to reach 14.4M flights in 2035 a 50% increase than in 2012. However, this has causeda severe increase in aviation pollution creating a need to decrease emission from aviation industry. Aviation accounts for 3%of the EU’s total greenhouse emission so to meet the 2016 European Commission milestones of 40% emission cuts by2030 and 60% by 2040electrification of aircraft is vital. Our concept for the future of regional air travel is the TailWind. It’s a fully electric plane, with9 seats and a range of more than 600km in 90 minutes. Created from a clean sheet design and elegant engineering, theTailWind uses innovations in storage, integration, thermal management and airframe design to achieve comfort andconvenience without the high cost, pollution and noise.Our revolutionary back-end plane design eliminates the drag of the tail and incorporates thrust vectoring, boundary layeringestion, active flow control, and distributed electric propulsion – each enabled by our unique propulsion design. Our firststep towards the creation of this highly ambitious concept has been to develop the heart of our aircraft, a custom propulsionsystem that is scalable to planes of various sizes and performance requirements. The system will optimise lightweightbattery packs and leverage our original powertrain. This architecture will form the basis of our future planes, and beretrofitted for integration into existing turboprop airframes resulting into drastic reduction of operating costs and elimination ofnegative environmental impact.With our disrupting technology, Ampaire will enable current polluting planes to be retrofitted and reduce their environmentalimpact. Our overarching mission, to create an affordable fully electric regional aircraft, will provide a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Quantum Internet Alliance' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The future Quantum Internet will provide radically new internet applications by enabling quantum communication between any two points on Earth. The Quantum Internet Alliance (QIA) targets a Blueprint for a pan-European Quantum Internet by ground-breaking technological advances, culminating in the first experimental demonstration of a fully integrated network stack running on a multi-node quantum network. QIA will push the frontier of technology in both end nodes (trapped ion qubits, diamond NV qubits, neutral atom qubits) and quantum repeaters (rare-earth-based memories, atomic gases, quantum dots) and demonstrate the first integration of both subsystems. We will achieve entanglement and teleportation across three and four remote quantum network nodes, thereby making the leap from simple point-to-point connections to the first multi-node networks. We will demonstrate the key enabling capabilities for memory-based quantum repeaters, resulting in proof-of-principle demonstrations of elementary long-distance repeater links in the real-world, including the longest such link worldwide.Hand in hand with hardware development, we will realize a software stack that will provide fast, reactive control and allow arbitrary high-level applications to be realized in platform-independent software. QIA's industry partners examine real world use cases of application protocols and their hardware requirements. We will validate the full stack on a small Quantum Internet by performing an elementary secure delegated quantum computation in the cloud. We will validate the design of the Blueprint architecture by a large-scale simulation of a pan-European Quantum Internet using real world fibre data. Through synergy of leading industrial, academic and RTO partners, QIA's Blueprint will provide a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Dual-targeted KetoFAPI Conjugates for Tumor-Selective Bimodal Therapy in Triple-Negative Breast Cancer' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

Triple-negative breast cancer (TNBC) remains one of the most aggressive subtypes of breast cancer, with limited therapeutic options and a poor prognosis. To offer dearly needed new treatment perspectives, we want to target fibroblast activation protein (FAP), a protease that is highly expressed on cancer-associated fibroblasts (CAFs) in tumors but negligible in most healthy tissue. Building on this rationale, the host institution has pioneered novel ketoFAPIs, small-molecule FAP inhibitors with exceptionally long tumor residence times, providing a unique opportunity to design advanced drug delivery platforms.This project will exploit the unique properties of ketoFAPIs to design bimodal conjugates that combine chemotherapy and radionuclide therapy in a single, tumor-targeted platform. These conjugates will integrate: (i) a ketoFAPI as the primary targeting moiety, (ii) a DOTAGA chelator for radionuclide labeling, and (iii) a cleavable linker for selective intratumoral release of potent chemotherapeutics such as MMAE or SN-38. To further enhance tumor selectivity and reduce bone marrow toxicity, a dual-targeting strategy will be pursued by adding folic acid as a second tumor-binding ligand. The project is structured into three objectives: 1) synthesis and characterization of Type I and II conjugates, 2) in vitro validation of efficacy and selectivity in TNBC organoid models, 3) in vivo evaluation of biodistribution, tumor uptake, and bone marrow safety in TNBC mouse models.By integrating long-residence FAP targeting with dual-modality therapy and dual-ligand selectivity, this research introduces a first-in-class therapeutic strategy for TNBC. Expected outcomes are optimized conjugates with enhanced tumor selectivity, reduced hematological toxicity, and improved therapeuti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Global Enterprise Network Support for the Innovation Process' (GENESIS).

assistant: **Innovation**

The project is a trial, whether and how process management can be applied to innovation processes (and more specific new product development and concurrent engineering processes) reflected in the project name: Global Enterprise Network Support for the Innovation Process (Genesis). The natural orientation for the development of process methodologies for the years 1994-1999 has been logistics processes in high tech industries. In the meantime most technology firms have achieved strong efficiency gains in logistics process and start shifting focus towards systematically re-engineering their innovation processes, for which methodologies by and large lack. Backed by market research and our early experience, we are convinced that the consortium's process method (VSD) provides a valid basis for systematic new business development with small adaptations. This industry trend is likely to create a valuable exploitation opportunity for the method. The Genesis-Trial aims to test the developed methodology in a telecommunications settings for application in new business development/co-development from inside dynamic networked and virtual organisations.Objectives:It is the objective of the proposed project to apply their process method to innovation processes (and more specific new product development and concurrent engineering processes). Members of the consortium have developed this method in earlier projects under the name Value System Designer (VSD). As found during the TELEflow project and stemming from an idea developed in the REWARD project and confirmed by literature, virtual organisations are best suited to generate wealth through innovation both for the participating firms and for society. However, new business development processes are even more difficult to operate and eng
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fourth Framework proposal on 'BUILDING A MULTILINGUAL WORDNET DATABASE WITH SEMANTIC RELATIONS BETWEEN WORDS'.

assistant: **Concept**

EUROWORDNET will produce a multilingual database for use in a variety of applications, including machine-aided translation and quality information retrieval. The database will establish basic semantic relations between words for several European languages. The wordnets will then be linked to the American wordnet for English to derive a shared top-ontology. In providing easy access to words and related meanings, the resources so obtained will enable terms employed in user enquiries to be expanded to any set of closely related terms in a language, resulting in better retrieval of information in terms of recall. http://www.let.uva.nl/ccl/EuroWordNet.htmlThe database has been designed with a number of important characteristics: - it is multi-lingual, - it can handle language-specific information extracted from diverse resources, - it provides a formal system usable in information retrieval applications as well as in the development of more complex knowledge bases of the future. The database also has some innovative features, such as: - an 'interlingual index', a pool of concepts (the superset of all language-specific concepts), where all shared language independent information is stored, - a facility to label relations such as disjunction, conjunction, factivity, reversal and negation, - encoding of explicit semantic relations across parts-of-speech, - different interpretations of particular WordNet 1.5 relations, - addition of new relations. For each relation language, specific test sentences are provided, with examples, to verify the relations between word pairs. Public guides for coding the semantic relations in each language will be published. The manuals provide a check-list and explain how the test should be applied to derive the semantic relations between word-meanin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'SIMULACRON: From Camera Observations  to Physical Simulations of the 3D World' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Despite their amazing success, we believe that computer vision algorithms have only scratched the surface in terms of understanding our world from images. While most research on 3D reconstruction has been concerned with recovering the surface geometry and reflectance, SIMULACRON is focused on inferring the underlying physics (masses, elasticity, momenta, forces, etc.) and a simulation of the observed action directly from videos.  This not only provides a more profound understanding of the observed phenomena, but it also allows us to interpolate and extrapolate complex actions far beyond the observation: The inferred physical simulation can be employed for space-time super-resolution and for predictions into the future.SIMULACRON covers three lines of research:A) We will develop algorithms for deformable shape modeling. We will explore suitable representations of 3D shape and its evolution that enable the efficient computation of shape deformation, correspondence, interpolation and extrapolation. These techniques will form the basis for inferring physical simulations in parts B and C.B) We will develop variational methods for inferring physical simulations from videos. We will compute a reference shape and simulation parameters that generate the shape deformation that is most consistent with the observations.  C) We will develop learning-based approaches for inferring physical simulations from videos. We will pursue two alternative approaches: First, we will generate synthetic training data by simulating deformable shapes and the associated camera observations. Second, we will devise self-supervised techniques for learning from real data without requiring labeled training data.By shifting from inference of 3D geometry to inference of physical simulations, SIMULACRON will
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Big Data to Enable Global Disruption of the Grapevine-powered Industries' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Big data is becoming a hype that is going to completely redefine industries within very traditional sectors like agriculture, food and beauty. The emergence of niche big data companies like Enolytics  (“bringing big data insights to the wine industry”) is threatening to disrupt these industries against the interests of the EU. BigDataGrapes wants to build upon the rich historical, cultural and artisan heritage of Europe in order to change this picture. It aims to support all European companies active in two key industries powered by grapevines: the wine industry and the natural cosmetics one. It will help them respond to the significant opportunity that big data is creating in their relevant markets, by pursuing two ambitious goals:a. To develop and demonstrate powerful, rigorously tested, cross-sector data processing technologies that go beyond-the-state-of-the-art towards increasing the efficiency of companies that need to take important business decisions dependent on access to vast and complex amounts of data, and assess them in challenges informed by the grapevine-powered industries.b. To create a large-scale, mulifaceted marketplace for grapevine-related data assets, increasing the competitive advantage of companies that serve with IT solutions these sectors and helping companies and organisations evolve methods, standards and processes to help them achieve free, interoperable and secure flow of their data.BigDataGrapes is targeting technology challenges of the grapevine-powered data economy as its business problems and decisions requires processing, analysis and visualisation of data with rapidly increasing volume, velocity and variety: satellite and weather data, environmental and geological data, phenotypic and genetic plant data, food supply chain data, econom
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Promoting S&T excellence and increasing the innovation capacity of the Transylvanian Institute of Neuroscience' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Neuroscience Neuroscience is an advanced field of science still poorly represented in Eastern Europe. Individual efforts have created some centres of excellence over the past years, mostly by scientists returning home from western labs. One such centre is the Transylvanian Institute of Neuroscience (TINS), located in Transylvania, Romania. TINS hosts one of the most important training centres in experimental neurosciences worldwide: the Transylvanian Experimental Neuroscience Summer School (TENSS). We propose a twinning between TINS and three internationally-leading European institutions from countries where neuroscience is most developed: Germany, France, and UK. TINS will twin with the Ernst Stüngmann Institute for Neuroscience in Frankfurt, Imagine Institute in Paris, and University College London. The objectives of the twinning are: i) to increase the scientific competence of TINS researchers; ii) to increase the innovation capacity of TINS; iii) to enhance the international visibility and prestige of TINS; iv) to improve TINS’ capability to compete for research funding; v) to promote the involvement of early stage researchers at TINS; vi) to enable TINS to become a neuroscience development pole in Romania and Eastern Europe. To attain these objectives, TINS and its three top international partners will organize periodically mutual research staff exchanges (short stays), training lectures at each institution, a top profile neuroscience seminar series at TINS, the TENSS summer school, periodic consortium retreats, dissemination and outreach activities with patient associations and industry, and collaboration among technology-transfer offices to implement best practices at TINS. The twinning will increase the scientific competence at TINS in neurosciences, develop a c
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Cracking the Nucleo-Olivary Code' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

For animals and humans to be successful in their environments, their motor and cognitive behavior must be adjusted to the constantly changing reality at a millisecond-timescale. For example, it is fairly simple for a brain to determine which muscles need to be activated to catch a falling object, but much harder to determine when and for how long. Without correct timing of the executive brain functions, as happens in some neurological disorders, the individual is unable to produce smooth and accurate movements and will also have difficulties with a range of cognitive functions requiring orchestration of distinct mental operations. The tripartite olivo-cerebellar system (OCS), which is formed by the inferior olive (IO), cerebellar cortex(CCTX) and cerebellar nuclei (CN), is considered critical for generating proper timing for many motor and cognitive operations. Interestingly, all three areas, IO, CTX and CN, have intrinsic oscillatory properties and together they constitute a reverberating microcircuit, beating with well-timed responses to requests from the sensorimotor system. The ultimate timing of the output of this system, by which it imposes its effects upon the rest of the brain, is mediated by the CN. Indeed, decades of research on the OCS has resulted in detailed concepts as to how it may generate and control computations with high temporal complexity. However, due to methodological difficulties the function of the nucleo-olivary (NO) pathway, which links the CN with the IO, has been neglected, hindering completion of the cerebellar theory. To crack the relevant temporalcodes of this loop I have developed specific viral optogenetic tools that allow for targeted control of the NO pathway. Using them I will define the NO interactions that take place during behavio