RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'UltrAfast correLated Two-dimensional mOiré Superlattices' (ALTOS), addressing dissemination and exploitation.

assistant: **Impact**

As one of the most fascinating phenomena in physics, strong correlation exists across a wide range of scales from planet to electron. Researchers have been pursuing a thorough understanding of strong-correlation phenomena for decades. In addition to the equilibrium correlated states detected by electric methods, nonequilibrium correlated dynamics that reveals more fingerprints of many-body interaction at a transient timescale is also significant. The emergence of two-dimensional (2D) moir superlattices provides an excellent platform to probe localized nonequilibrium correlation phenomena by ultrafast laser excitation and spectroscopic detection with high resolution in both space and time. The combination of large moir lattices in space and femtosecond-scale resolution in time will offer us a powerful tool to unravel the signature of unconventional dynamics of strong-correlated states, which not only deepens our understanding of complex quantum systems but also holds promise for the development of advanced technologies with transformative applications in fields like quantum computing and energy transmission.  This interdisciplinary training scheme aims to enhance Dr. Shangs expertise in photonics, strengthening his skills and helping him establish a research career in Europe. The program covers component design and implementation, theoretical analysis and photonics experiments. To assist Shang in reaching professional maturity and increase his exposure to academic and industrial collaborations, he will receive training on intellectual property management, funding and proposal writing, commercialization, business and finance management, supervision, and teaching. Additionally, Shang will have the opportunity to establish cooperation with Prof. Abajo (ICFO, Spain) as part
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Novel innovative doubled haploid technology for ornamental and medical plant breeding'.

assistant: **Innovation**

Medicinal and ornamental plants are of great and diverse importance for human health and daily life. They cover a large market in Europe and world wide, exceeding billions of Euros. Improving the quality of medicinal and ornamental plants is mandated by a need to produce better medicines, particularly better defined herbal medicines, and new ornamentals to please the senses. At the same time, however, the improvement of ornamentals and medicinal plants is using old fashioned, traditional methods, because breeding is done mainly in small, family-owned companies and because own funds and funding from governmental sources is lacking.The proposed project is the first concerted effort to bring together academic research institutes and several small and medium-sized enterprises (SMEs) from a five EU countries and new membership country to develop innovative doubled haploid technologies to obtain homozygous pure lines in a single generation as a core for breeding of important selected ornamentals and medicinal plants. These benefits may accrue to immenseadvantages to these SMEs and ultimately, for the European ornamental and medicinal plant industry. For the first time a large number of important ornamentals and medicinal plants will be screened for doubled haploid production via gynogenesis (cultured ovaries and ovules) and androgenesis (anther and isolated microspore cultures). Basic protocols expected to be developed during the course of this project will have wide applications also in other important crop species and cultivars. Thus, the project will arm ornamental and medicinal plantbreeding with new, innovative doubled haploid technologies, which might revolutionize breeding.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Gas turbine combustion with Reduced EmissioNs Employing extreme STeam injection' (GREENEST), addressing dissemination and exploitation.

assistant: **Impact**

Global energy consumption is continuously increasing, leading to an increased world wide demand for new power generation installations in the near future. In order to protect the earth s climate, energy conversion efficiency and the use of sustainable resources have to be improved significantly to reduce the emission of the greenhouse gas CO2. To maintain our high standard of living and to enhance it for developing countries, the improved technologies have to be cost-neutral. Gas turbines play today a major role in energy generation. In the future, gas turbines will become even more important, when old coal-fired steam cycle power plants are replaced by integrated gasification plants. However, current gas turbine technology experiences a flattening technology curve and further increase in total efficiency at low NOx emissions is only achieved in incremental small steps. Additionally, current technology is not prepared to operate on hydrogen-rich fuels from biological resources or coal gasification. A new approach was developed that promises a significant improvement in efficiency and emissions and provides the ability to burn hydrogen-rich fuels. For operation on carbon-containing fuels, it enables CO2 capture at low cost. The concept is based on a high pressure air-steam gas turbine cycle using extremely high amounts of steam. The goal of the proposed project is to investigate the fundamentals of ultra wet combustion to develop the technology for a prototype combustor which is capable of burning natural gas, hydrogen and fuels from coal or biowaste gasification at low NOx emissions. Research will include the combustion process, the aerodynamic design, acoustics and control, combining the main disciplines of the Chair of Experimental Fluid Dynamics.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Preparation and characterization of cu- and fe-zeolite catalysts for nitrogen oxide decomposition' (1994-1998).

assistant: **Innovation**

Research objectives and content Much interest in environmental catalysis is now focused on the development of novel catalytic reactions for depolluting NOx in lean-burn conditions. Due to the high activity showed by Cu-and Fe-exchanged zeolites in the catalytic decomposition of NO, and the influence of some parameters like local environment of the copper/iron species in the zeolites, structure of the zeolitic matrix, etc. on their catalytic behaviour, we propose a research project with the following main aims: - to prepare Cu-and Fe-zeolites following different exchange routes - to characterize the oxidation state, coordination symmetry and local environment of copper/iron species in these materials using appropriate techniques - to test the catalytic activity of some selected samples Training content (objective, benefit and expected impact) The project will allow the candidate to improve her knowledge on techniques like FTIR and XRD and to learn the use of new ones such as EPR, UV-Vis, photoluminiscence and Raman spectroscopies. The daily work with experts in all of these disciplines will also be very useful to the candidate. Besides, this project will allow to consolidate an already existing collaboration between the Spanish laboratory where the candidate is working now and the Italian group. Links with industry / industrial relevance (22) The host group collaborates with the Italian Chemical Industries ENICHEM and ENEL, both of which are very interested in this research project, and offer their laboratories for part of the research experiments to be performed.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Plug and play LED lighting control and monitoring system for new and existing installations' (WIISAS), addressing dissemination and exploitation.

assistant: **Impact**

As energy consumption rates rise around the globe so too do emissions rates. By 2040 there will be a 30% increase in energy demand. In the EU buildings are responsible for 40% energy consumption and 36% of CO2 production. Lighting takes up 40% of this output. A growingly conscious consumer is looking at ways of both saving their pocket and the planet and is seeking out LED lights and smart lighting. The problem with these is that they require a skilled electrician to install and maintain them, adding extra monetary and time costs to the product. As data driven decision making becomes a key mechanism for optimum change we note there is little information on consumption and spending patterns of lighting.Valtavalo’s WIISAS enables installation and retrofitting of IoT lighting without an electrician. WIISAS’s patent-pending technology uses sensors to group lights where and when needed wirelessly. This optimizes the tube lifetime and enables easy maintenance as notifications are sent when there is failure. WIISAS is a cost effective solution with savings of up to 90% compared to a traditional incandescent bulb. Connected to the cloud you are able to see exactly where and when your lights are activated, informing on spending habits, wasted spaces and building security amongst other uses. An intelligent monitoring lighting system that makes smart lighting easily accessible to the non-technical, WIISAS uses power harvesting technology to save your pocket and the planet.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Molecular Biology of Cellular Interactions' (1998-2002), addressing dissemination and exploitation.

assistant: **Impact**

The biological processes that occur at the cell surface have profound effects on the behaviour of cells and organisms. Today, cell surface phenomena mediated by adhesion receptors are major areas of research in all disciplines of modern biology, ranging from physiology and development to immunology, neurobiology and cancerology. The past 10 years have witnessed tremendous progress in our knowledge of adhesion molecules and their functions. Cell adhesion receptors include different families of proteins such as integrins, cadherins, molecules of the Ig superfamily (also referred as to CAMs), syndecans and Eph receptors. These molecules represent an integrated sensory system for transducing positional information of crucial importance in controlling the correct organization of the body plan during development and several patho-physiological processes in adult organisms. Adhesion molecules act as genuine surface receptors which convey biochemical signals inside the cells regulating tyrosine kinases/phosphatases, GTPases, lipid metabolisms, intracellular ionic concentrations.Although the basic molecular events flowing from single activated adhesion receptors have been partially described, new questions arise from this work that will represent major research topics in the next few years. It is clear that signalling pathways by adhesion receptors do not function separately, but are highly integrated with that of other surface receptors and the underlying cytoskeleton. A paradigmatic example of such integration is the absolute requirement of cell adhesion for proliferative response to mitogens. It is, thus, crucial to elucidate the structural basis of adhesive receptors cross-talk with other cell surface molecules such as cytokine, growth factor receptors, and other adhesion re
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Health and Huntington’s Disease' in the context of a Horizon 2020 call.

assistant: **Objectives**

Fast axonal transport (FAT) of brain-derived neurotrophic factor (BDNF) is essential for brain function. It depends on huntingtin (HTT), the protein that when mutated causes Huntington’s disease (HD), a devastating and still incurable disorder. Unmet scientific needs: BDNF is regulated by neuronal activity and its transport requires energy. Yet we do not know if FAT of BDNF is regulated by neuronal activity and if HTT facilitates activity-dependent transport. The energy sources for FAT of BDNF and their regulation by activity remain unclear, as do the exact mechanisms of BDNF transport reduction in the HD-causing mutation. Novel hypothesis: HTT plays a key role in channeling energy by coupling energy production by glycolytic enzymes on vesicles to consumption by molecular motors for efficient axonal transport. This function is altered in HD and plays a crucial role in disease progression. By providing energy directly to vesicles, we can restore transport and slow down neurodegeneration in HD. Aim 1: investigate energy sources for axonal transport and their regulation by HTT upon high neuronal activity. Aim 2: investigate how pathogenic mutation in HTT affects response to neuronal activity and vesicles capacity to produce energy. Aim 3: restore energy sources in HD to rescue axonal transport and slow down neurodegeneration. Impact. This work will advance the understanding on how electrical activity essential for brain function regulates energy metabolism to fuel transport, specifically transport of BDNF. We will reveal essential new knowledge on the HTT function and dysfunction. This will likely lead to novel therapeutic strategies for HD. Feasibility: we have expertise in developing innovative microfluidic circuits for studying axonal transport in reconstituted neuronal
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Targeting ASTROcytes with cutting-edge EDITING technologies to treat the Alexander disease' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Alexander disease (AxD) is an autosomal dominant neurodegenerative disorder caused by missense mutations in the gene encoding the glial fibrillary acidic protein (GFAP), the major intermediate filament protein in astrocytes. Accumulation of GFAP aggregates in Rosenthal fibres leads to impairment of proteasomal activity and hyperactivation of the stress response, thus compromising astrocyte functions and altering the homeostasis of the central nervous system (CNS). Currently, this orphan disease lacks a cure. The proposed project aims at providing in vivo proof-of-concept of safety, efficiency and efficacy of a novel and definitive AAV gene therapy approach based on gene editing / base editing strategies targeting GFAP mutational hotspots to recover pathological phenotypes in astrocytes. The candidate expects to outline novel editing platforms for widespread in vivo targeting of CNS astrocytes that could be applied for the treatment of AxD, as proposed in ASTRO-EDITING, and prospectively for disease modelling studies and therapeutic treatments of other neurological and psychiatric disorders by targeting pathological pathways involved in primary astrocyte degeneration or dysfunctional/maladaptive astrogliosis.The proposal addresses the European issue of Horizon 2020, in the social challenge “Health, Demographic Change and Wellbeing” endeavours for the call “Better health and care, economic growth and sustainable health disease”, subject SC1-BMC-04-2018 “Rare Disease European Joint Programme Cofund”. The expertise of the host laboratory, the international environment of OSR and the personalized career development plan will significantly reinforce candidate's competences and knowledge in the gene therapy field, expand his portfolio of therapeutic areas, create a new researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Sixth Framework proposal on 'Targeting newly discovered oxygen-sensing cascades for novel cancer treatments Biology, equipment, drug candidates.'.

assistant: **Innovation**

The last decade's basic and clinical oncology research has revealed a number of so far unrecognised regulating responses (e.g. HIF-1) in cells exposed to hypoxia. These processes have been proven highly important for embryonic development and survival and seem to have a major impact on tumour progression and resistance to radiotherapy and certain types of chemotherapy. Because of their strong over-expression in solid cancer tumours in comparison to adjacent normal tissue of these processes, this new knowledge may open a therapeutic window for cancer treatment by utilising hypoxia-responsive processes as drug targets.Major EU stakeholders in academic research and industry will therefore explore and validate these new molecular targets as a necessary step in the preclinical development of innovative new diagnostics and treatment.Our committee has identified the outstanding basic problems to be solved over the first 2 to 3 years in order to allow a successful drug development. These include: dissection of relevant steps in cancer cell response to hypoxia, development of the technology platform needed, further identification and characterisation ofmarker/target molecules, and initial in vitro drug development. Our own mid-term evaluation will then select which hypoxic processes may be suitable as targets for cancer-specific treatment.Simultaneously, we will study diagnostic tagging and therapeutic strategies leading up to a selection process of promising compounds to be further developed after the end of the project period. The new treatments will be developed along two lines: targeting known cytostatics towards the newly discovered hypoxia-responsive molecules and searching for so far unused compounds, preferably toxic to pathways active during hypoxia. The final effort wi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Launching A Unified Cloud-Based Platform for Next Generation Protein Editing' (ZYMVOLVER).

assistant: **Innovation**

Actually, global enzymes market is today €8.18 billion and forecasted to reach €17.5 billion by 2024, so a sector growing at a CARG +9.56% in a 7-year projection.  Europe is a main contender with over 62% of the exports. However, most companies with dedicated software for protein engineering computational are found in North America (46.0%), followed by Europe (29.4%), Asia-Pacific (17.9%) and RoW (6.7%).  The production of daily life products such as paper, textiles, food, feed, chemicals and pharmaceuticals consumes large amounts of resources, water and energy. Furthermore, it generates enormous amounts of waste with an adverse impact on our environment and quality of life. Many studies show that implementing enzymatic processes instead of conventional chemical catalysis contributes to a more sustainable industry, reducing global warming (OECD, 2009; European Commission, 2009).ZYMVOLVER is a computer-driven speciality management to protein producers and industrial manufacturers. It offers a computer-aided decision-making tool for the adoption of industrial enzymes in standard industrial processes. We have developed a tool that will allow the democratization of computer-aided protein engineering. We offer a state-of-the-art, accessible, all-in-one computational tool that customize proteins with a 90% accuracy in terms of substrate selectivity, far beyond competition. ZYMEVOLVER -  is exclusively owned by Zymvol. Our cloud-based, cost-effective software allows us to design any industrial enzyme from scratch, saving 50% of time and enzyme developing costs.The founding of Zymvol Biomodeling SL has over 20 years of combined experience previously working at one of Europe’s most important supercomputers – Barcelona Supercomputing Centre, which has been a necessary infrastruct