RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'ELIMINATION OF PARASITIC COPEPOD IN FARMED SALMON' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Salmon farming is a big industry with ca. 14,000 mill. € per year in the world., mainly in Norway and Chile. One of the greatest problems for salmon farming is the parasitic copepod, a sea-lice which hangs in the fish avoiding its growth, producing wounds and even the death. It causes a cost of 300 mill. € per year in Europe. Nowadays the fight against this parasite is the use of chemicals and drugs. It goes against the organic farming and the companies general interest because of the lost of increasing organic market, the bad image of salmon farming and its elevated cost. Other negative impacts in environment and natural fish stocks can also be found.The project deals with an innovative method for sea-lice elimination in salmon farms. It is the use of invertebrate filter feeders which eat the parasitic copepod in its early free-living planktonic stage. It avoids the parasitic copepod reachs its adulthood in the parasitic stage when it hangs in the fish.The method is totally environmental friendly, organic farming compatible and cost-effective. Preliminary cost analysis shows a 25% of cost savings and it might also coproduce commercial filter feeders in the same salmon farm. Moreover the method is almost totally developed, having reached a TRL 8 after laboratory, pilot scale and operational environment demonstration.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Novel Atg4B-inhibitors and dual [Atg4B-carbonic anhydrase] inhibitors for interfering with cytoprotective mechanisms of cancer cells in the acidic tumor micro-environment.' (ONCOPHAGY) targeting Horizon 2020.

assistant: **Abstract**

The microenvironment of most solid tumors tends to be significantly more acidic than healthy tissue. Inadequate perfusion, oxygen limitation and cell metabolic changes, are key causative factors for this situation. The acidic pH induces a number of specific genetic, transcriptional and metabolic effects in tumor cells. These are required for survival under increased H+-stress. Evidence is now mounting that these effects also play a major role in tumor progression, invasiveness and the development of multi-resistance to therapy. Two pivotal adaptations related to maintaining intracellular pH homeostasis in an acidic environment, have recently received significant attention: (1) the presence of chronic autophagy in tumors and (2) the overexpression of carbonic anhydrases (CAs), mainly CA IX and CA XII. This project will biopharmaceutically optimize a novel class of specific autophagy inhibitors that target Atg4B. The specific goal of this part of the project is to obtain orally bioavailable and metabolically stable compounds that are fit for in vivo applications. The relevance of these compounds is clear, given the unmet demand for reliable, specific inhibitors in the domain of autophagy. At the same time, the project will evaluate the potential for therapy development of the compounds in the framework of cancer. Finally, the proposal will explore whether a further increase of anti-tumor efficiency can be obtained by combining Atg4B- and CA-inhibitor pharmacophores in a single compound.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'High Performance Fibers'.

assistant: **Concept**

Fibers stand as the strongest and stiffest materials and constitute the critical component of composites, which are rapidly replacing traditional materials in structural applications. The outstanding fiber properties come from the strong ionic covalent or metallic bonds, which sustain the load. As the ductility of these links is very limited, fibers are brittle and their ultimate strength is controlled by their fracture behaviour. Further improvements in fiber properties can be obtained through a deeper knowledge of the physical mechanisms involved in fiber fracture, and this is the main objective of the interdisciplinary workshop in fiber fracture. Evidently, improving the fiber properties will have significant consequences in the development of new composite materials with enhanced properties. The micromechanisms of fracture depend on the fiber nature and structure. The workshop will get together leading scientists working in polymeric (either natural or synthetic), metallic and ceramic fibers, which will present the current development in each field improve the fracture resistance of high performance fibers.It is expected that successful ideas in the development of a kind of fibers may lead to cross fertilization in other field, and the discussions among scientists with different backgrounds will be encouraged. The workshop also expects to provide a balance between basic research and industrial applications by choosing invited speakers from academia, research laboratories and industrial enterprises. The main conclusions of the meeting will be summarized in an overview session the last days of the meeting. In addition, all the invited talk will be published in a special issue of the international journal Engineering Fracture Mechanics.ftp://ftp.cordis.lu/pub/improving
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tailor-made Recycled Aggregate Concretes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Concrete is the main construction material used on earth. The increasing population and urbanization has led to construction of new high-rise buildings and demolishing existing old low-rise ones. This has become not only the cause of natural resources depletion at an alarming rate but also gradually becoming a challenge for environmental preservation. Concrete industry consumes a majority of natural resources and produces a large amount of construction waste. In order to ensure sustainable, cost-effective but still profitable concrete production, extensive research is needed to investigate how concrete industry can produce green concrete by using less nature resources and producing less waste. The aim of the proposed research is to develop tailor-made concretes by using more recycled concrete aggregate (RCA) for structural applications. The use of RCA as granular material in pavement design has been a long history. However its use in structure concrete has not been widely accepted, primarily due to the poor quality found in RCA. To overcome this technical difficulty one has to understand the behaviour of RCA and to find a way in which the quality of the RCA can be improved and controlled during its mixing process. This requires a systematic research into various specific aspects of RCA and recycled aggregate concrete products. This proposed RISE programme is to bring together an international team of researchers with a wide variety of skills, to tackle the challenges faced by construction industry. The proposed research covers the fundamental study of cementitious materials as well as their applications in different construction fields. The outcome of the research will provide vital information on how to revolutionise the production of concrete materials and how to engi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Repair of Diabetic Damage by Stromal Cell Administration', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

50 million diabetic EU citizens are using approved anti-diabetic agents to control their glycaemia. However, suboptimal glycemic control leads to 6 progressive diabetic complications, namely: nephropathy, retinopathy, cardiomyopathy, neuropathy and foot ulceration. In 2010, 11% of EU adult deaths (634,000) were caused by diabetic complications. These distinct disorders have few effective medicines and present challenging management issues for clinicians. Stromal Stem Cells (SSC) are a mixed population of plastic-adherent (PA) cells isolated from adult bone marrow. PA-SSC secrete potent immunosuppressive and angiogenic proteins and over 100 clinical trials are testing PA-SSC in 40 distinct autoimmune and ischemic diseases. Notably, preclinical studies show a single intravenous administration of un-modified PA-SSC can control rodent hyperglycaemia, prompting 10 recent clinical safety studies in diabetic patients. REDDSTAR will comprehensively examine if SSC can safely repair all 6 damaged tissues and control glycaemia in three different species. To facilitate this we identified an antibody (S2) that prospectively isolates comparable, equivalent S2+SSC from human, rat, mouse and rabbit marrow, enabling testing of pure S2+/- SSC and mixed PA-SSC from each species for the first time. Furthermore, separation of PA-SSC into S2+ and S2- fractions reveal functionally distinct populations. REDDSTAR partners have collectively developed five distinct clinically-relevant in vivo models of the 6 key diabetic complications. We will assess if S2+, S2- and PA-SSC exert differing control of glycaemia and tissue repair in each model. Finally, REDDSTAR partners are developing the first benchtop GMP-grade nanosorter, enabling clinical purification of S2+ and S2- SSC for human safety trials.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Magnetic Fluids and Porous Media for Active Dampers.' (1994-1998).

assistant: **Concept**

Foreseen ResultsThe direct output of this project is the final product: active dampers for a wide range of utilization. These active dampers could be used on aircrafts (landing dampers) on trains, buses, underground carriages (damping of lateral vibration and improvement during acceleration and decceleration periods) on cars (improvement of comfort and security). Other applications are expected in isolation of vibrations transmitted by engines or machines with moving parts. Bumpers could be built as special dampers whose function is to dissipate the energy of a shock with an optimal law of decceleration for a given impact force and stroke of the piston. Small size active dampers could also serve on deformable structures submitted to random forces (for instance cables or any suspended structure acted on by the wind).On the other hand this study should bring a significant contribution to other fields of research:The understanding of flow magnetic fluids in channels is important for other applications of these magnetic fluids (pressure distribution in actuators, heat exchanger, even flow of magnetic particles in blood vessels for medical diagnostic or curing).The understanding of invasion of porous media by a non wetting fluid and especially of the microscopic mechanisms responsible for the hysteresis and the dissipation during a series of cycles is a very promising domain both for theoretical and applied research.In Western Europe no company sells magnetic fluids. These companies are either in USA (Ferrofluidics, Lord Corporation) or in Japan. A few laboratories or recently created firms are proposing ferrofluids in Eastern countries (among them the laboratory of Pr. Bashtovoi). Our study should contribute both to the improvement of these fluids (stability, higher change
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Validation of a method and device for the surface treatment of a substrate by a novel plasma spraying technique' under Fourth Framework.

assistant: **Concept**

The objective of this project is to develop plasma torch prototypes that are capable of producing a flame 20 cm or more wide. The RTD goals are to develop a breadboard model in order to gather additional performance data to results obtained as a proof of concept. The technical parameters obtained will enable the construction of pre-production prototypes for evaluation in regard to their intended application areas, which in this case is the heat-treatment of textiles and the deposition of metallic and other powders including thermoset and thermoplastic. Powder feed systems will be developed alongside the plasma torch for this purpose.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Drosophila sechellia: a novel model to investigate nervous system and behavioral evolution' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

How animals’ extraordinarily diverse behaviors have evolved is unknown. Relating interspecific behavioral differences to anatomical or physiological distinctions in neural circuits, and causal genetic variation, offers a powerful approach to inform how nervous systems develop, function and change.Understanding behavioral and nervous system evolution requires deep investment in select species. We propose to establish a new model neurogenetic system: Drosophila sechellia, an island endemic that is closely related to D. melanogaster and D. simulans. While D. sechellia retains global genomic and superficial morphological similarity to its cosmopolitan generalist cousins, this species has adapted to a unique ecological niche, using Morinda fruit as a sole host for feeding and breeding. The project has three aims:Aim 1. Establishment of a D. sechellia (neuro)genetic toolkit: we will build essential genetic reagents for generation and maintenance of animals of desired genotypes, for neurogenetic manipulations, and for recombination mapping-based approaches.Aim 2. Behavioral, neuroanatomical and molecular phenomics: systematic comparison of D. sechellia, D. simulans and D. melanogaster for their behaviors, their neuroanatomy and their neuro-molecular expression properties will reveal how D. sechellia has adapted to its niche, and will provide multiple entry-points to relate molecular, neuronal and behavioral differences between these species.Aim 3. Defining the genetic basis and functional significance of a neuronal adaptation in D. sechellia: through high-resolution mapping and allele swap approaches, we will identify the causal genetic changes underlying a neural adaption in D. sechellia, and its physiological and behavioral significance.This project will establish a powerful
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Patient's autonomy and privacy in nursing interventions' under Fourth Framework.

assistant: **Concept**

OBJECTIVES- To describe and analyse patients' autonomy and privacy as it applies to nursing interventions in European hospital organisations.- To identify the problems in patients' autonomy and privacy.- To develop teaching programmes for nursing education in the area of nursing ethics.Basic theoretical assumption for the project is: patients in health care organisations are autonomous persons, whose privacy should be protected and who should consent with the nursing interventions to be done.BRIEF DESCRIPTIONThe project is organised in two phases. First, a literature review and concept analysis about the concepts of autonomy, privacy and informed consent will be done. Based on the analysis, a questionnaire will be developed. The first version of the questionnaire will be formulated by the co-ordinator and will then be developed, translated and piloted by the associated partners. In the second phase the questionnaire will be used in the empirical data collection in each of the collaborating countries.The sample of the empirical part of the project consist of patients and nurses. In the patient sample (N= 3000-4500), there are mothers having their babies in the postnatal wards, surgical patients and dependent elderly patients in long-term care. In the nurse data, there are nurses and midwifes from corresponding wards in University and general hospitals. Nursing interventions to be studied are feeding (including breast feeding in postnatal wards), elimination, medication and body hygiene. Analysis of the data will be statistical.The deliverables of the project are mainly contract ones. There will be two main international and national reports, first based on the literature review and second based on the empirical data. Also a teaching programme for nursing education will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Development of a business model to commercialise GPU accelerated workstations for European hardware providers' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Company: We (ebb3 Ltd), an accredited specialist systems integrator are developing software in partnership with market leading technology providers (Cisco, Citrix & Nvidia). Our partners have been selected specifically for their interoperability and global market positioning. ebb3 will use our partners existing software and hardware components as the foundation to provide and manage a common GPU (Graphical Processing Unit) accelerated computing platform. Problem: Whilst many organisations are moving their data into the cloud, there are applications and workloads confined to physical workstation computers where the GPU is commonly located and not cloud compatible. As workstation applications become more complex and resource demanding, their data files become even larger. This data transfer to and from the cloud is time consuming and impacts an organisations security data availability policies and risks the value of the data.State-of-the-art: All the current virtual workstation solutions, are either public or private shared cloud solutions, meaning that they are also in a public cloud, with multi-tenant pooling of resources among multiple customers, increasing issues of data privacy and security. In addition, cloud-based solutions often require dedicated resources creating islands of technology that become cumbersome and costly to maintain and support. Most virtual workstation solutions do not manage the set-up, user resource pool usage or provide support services when the workstation is not performing, meaning users experience periods of high latency, poor performance and difficulty accessing resources.Our solution: ebb3 offers customers a fully managed, private cloud dedicated common GPU accelerated computing environment (CGACE) that uses an AI resource management tool
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DETECTION AND LOCATION OF CONCEALED PLASTIC EXPLOSIVE IN ON-LINE BAGGAGES SCREENING BY TOMOGRAPHIC INTERROGATION BY NEUTRON ASSAYING' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

Detection and Location of Concealed Plastic Explosive in On-line Baggage Screening by Tomographic Interrogation by Neutron Assaying The goal of the project is to develop an innovative system for the location and identification of concealed plastic explosives in on-line screening of checked in baggage in airports, using Tomographic Interrogation by Neutron Assaying. TINA represents an entirely new concept of concealed explosive detection: the combination of a compact, short pulse, high-energy neutron and X-ray source and a new detection methodology based on the assignment and matching of a colour signature to specific groups of chemical elements forming explosives. The system offers 100% detection capability, low false positives, low operator involvement, high throughput and high sensitivity at realistic costs. TINA has a number of innovative features, which are more than merely evolutionary steps. To validate the technology for an on-line screening system for checked in baggage that can meet today's airport security requirements needs: - to detect explosives of any kind and shape, from a quantity as small as 250g; - to assure a flux in excess of 450 baggage per hour; - 100% detectability that is 0% false negatives; - low false positives (<5% single pass), The objective is to be met in TINA by the development of a technology based on the fusion of four techniques: - pulsed fast neutron analysis (PFNA), - neutron absorption analysis (NAS), - thermal neutron analysis (TNA) and - X-ray imaging, TINA comprises teams from France, UK and Germany, involving technology providers system integrators and end-users. The project provides management and the technology transfer between National bodies, Public utilities and SMEs including NTBF. The performance requirements in baggage sc