RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Interspecies politics in Himalayan borderlands from the mid-nineteenth century to the present' in the context of a Horizon Europe call.

assistant: **Objectives**

Climate change, escalating geopolitical tensions, and domestic civil unrest have multiplied the claims made on Himalayan territories cohabited by animals and humans in the name of security, conservation, and development. Hence, the study of human-animal conflicts has become a major area of focus for International Non-Governmental Organizations (INGOs) like the World Wildlife Fund for Nature (WWF). Despite their efforts, scholars point out that current approaches by INGOs discount the interconnected nature of historical, cultural, and political dimensions of human-animal interactions, which limits their ability to create sustainable and just solutions to the ongoing processes of political, ecological, and economic transitions for indigenous communities and their non-human cohabitants, both in the Himalaya, as well as across the globe.INTERSPECBORD examines how interspecies politics historically shape the mobility and identities of human and animal bodies in South Asian Himalayan borderlands from the colonial period in the mid-nineteenth century to the present. Rather than approaching this subject from the perspective of the ‘global south’ or ‘global north,’ this project will emphasise the role of circulation and the ways that different assemblages of ideas, technologies, people, and animals move across space and how historical encounters between these assemblages both shape and are shaped by Himalayan borderland places and ecologies. Against this historical background, this project will investigate how human and non-human species co-produce new bordering practices, which includes hybrid identities, practices of social differentiation, and novel ways of establishing control over borderland spaces. Methodologically, INTERSPECBORD is an interdisciplinary project combining h
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'The role of telomerase in human cancer develpment and an evaluation of its potencial as a therapeutic target'.

assistant: **Concept**

Telomerase is an attractive target at which to aim novel cancer drugs because it maintains tumor cell immortality, and is inactive in the majority of normal human cells. In this project we will determine the precise molecular mechanisms by which telomerase is repressed in normal cells and activated in human cancer progression. Genetic inhibitors of telomerase will be developed and used to provide unequivocal evidence that anti- telomerase strategies induce replicative senescence in cancer cells, in the absence of cellular resistance machanisms. Novel reagents and procedures will be established for use in telomerase-based cancer diagnosis and in prognostic evaluations. Small molecule lead compounds (from a natural product library) that act as potent inhibitors of telomerase will be identified and characterized, as a basis for anti-telomerase drug development.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'MIXed plastics biodegradation and UPcycling using microbial communities'.

assistant: **Innovation**

The continuing demand for plastic products, the lack of appropriate recycling and the ubiquitous pollution of the environment with plastic waste pose a global challenge. An ambitious vision and considerable efforts are required to change the traditional value chain of plastics to a sustainable one, based on biodegradable plastics.In MIX-UP, plastic mixtures with five of the top six fossil-based recalcitrant plastics (PP, PE, PUR, PET, and PS), along with upcoming biodegradable plastics such as PLA and PHA, will be used as feedstock for microbial transformations, thereby generating a workflow that increases the recycling quota and adds value to poorly recycled plastics waste streams. Successive controlled enzymatic and microbial degradation of mechanically pre-treated plastics waste will be combined with subsequent microbial conversion to value-added chemicals and polymers by mixed cultures. We will optimize known plastics-degrading enzymes for high specific binding capacities, stability, and catalytic efficacy towards a broad spectrum of plastics polymers under high salt and temperature conditions by integrated protein engineering, and also isolate novel enzymes with activities on recalcitrant polymers. MIX-UP will also optimize the production of enzymes and formulate enzyme cocktails tailored to specific waste streams. Implementation of these enzymes, both in vitro and in vivo, enables stable self-sustaining microbiomes to convert the released plastic monomers selectively into at least six value-added products, key building blocks, and biomass. Any remaining material recalcitrant to enzymatic activity will be recirculated into the process after a physico-chemical treatment.The Chinese-European MIX-UP is a multidisciplinary and industry-driven consortium that addresses
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Pioneering Unprecedented Life-Saving Equipment: Intelligent Aortic Balloon Catheter for Cardiac Arrest'.

assistant: **Innovation**

With a worldwide incidence expected to increase from 9 million cases in 2023 to 11 million cases by 2030, cardiac arrest is a public health crisis with a survival rate at only around 10% and a high degree of brain damage among the few survivors. Defibrillators cannot be used in 76% of cardiac arrest patients due to a non-shockable rhythm, leading to an extremely low survival-to-discharge for these patients (3.3%).Neurescue Aps (NEUR) addresses the cardiac arrest burden by bringing to market a game-changing solution – the Neurescue device – the world's first intelligent fluoroscopy-free aortic balloon catheter. By combining unique proprietary features including 1) an intelligent system for automated balloon inflation and deflation managed by the controller component, coupled with 2) precise positioning feedback from the patented sensor system in the catheter, these together provide a safe computer-controlled aortic balloon occlusion for use both inside and outside hospital settings. The Neurescue device increases blood flow to the heart and brain, which makes the patient more likely to respond to resuscitation efforts. This also increases the likelihood of bridging patients to definitive therapies, extending the critical time window from the current 20-30 min to ~60 min. This is especially valuable in patients with a non-shockable rhythm for whom the standard of care (SoC) results in extremely low survival (3.3%). The use of the Neurescue device, both inside and outside hospitals, is expected to increase the survival rate of cardiac patients by up to 40% - thereby holding the potential to save millions of lives.The Neurescue device is projected to be ready for commercial roll-out by 2027 reaching €931.37M in revenues by 2033. The PULSE project aims to surpass the main ma
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Novel Automated System for Farming of European Lobster' (AUTOMARUS).

assistant: **Innovation**

European lobster (EL, Homarus gammarus) is among the most exclusive shellfish products worldwide, but stocks collapsed in the1950s and have not recovered in the decades since. The global demand for lobster far exceeds supplies, and neither EL nor captureproduction of lower-quality American lobster (H. americanus, AL) can fill the market gap. With the price of EL at €25-35/kg, theEuropean seafood industry is missing out on a clear market opportunity. Land-based aquaculture is the remaining alternative, butcurrent aquaculture methods are practically, technologically and commercially unviable as lobsters are highly cannibalistic andcannot be reared in groups but must be cultured in individual cages necessitating unfeasibly high personnel costs. Tha aim of the AUTOMARUS project is to mature, prototype, pilot and implement the first Recirculating Aquaculture System (RAS) based EL farming solution in individual cages using fully automated feeding and real-time monitoring and robotic lobster handling for the production of European Lobster. Our innovative solution will thus enable profitable and sustainable large-scale production of high quality EL for the first time to fit the market gap and create a novel value chain for farmed EL. The AUTOMARUS project will be run by a strong mnagement team with a proven track record in lobster aquaculture, engineering and robotics/automation as well as managing and scaling R&D-intense companies. With a production target of 1,000 tonnes by year 5 after project end, NLF will be the sole supplier of farmed EL and expect to take a 16% share of the European lobster production market and 8% the total market for EL and AL across EU and Asia.


**Keywords:** RAS, land-based, lobster farming, value chain innovation, robotics, automation
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'Pathways to survival in a hotter world'.

assistant: **Innovation**

Global warming and heatwaves – hallmarks of climate change that are expected to worsen in the 21st century – diminish reproductive success and cause excess mortality in wild and domesticated animal populations. Yet, we still have sub-standard knowledge of almost all fundamental traits that medi-ate success or failure under climate change, and, for most animals, there are no data on the extent to which plasticity, local adaptation, or evolutionary change can alleviate the stress imposed by a hotter world. Collectively, therefore, the research field is at status quo. To mitigate this situation, HotLife will leverage my previous phenomenological studies on ontogenetic priming and plasticity of thermoregulatory capacity to generate novel knowledge on when and why animals fail in the heat, and whether plastic or evolutionary responses may render failure a less likely outcome in the future. The main outcomes of HotLife will reveal: 1) How heat tolerance manifests, how much it can evolve, and whether plasticity halts evolutionary rescue; 2) Whether climate warming and climatic extremes directly or indirectly cuts life expectancy short; and3) If the physiological basis for heat tolerance is inherited in the wild and if it is already being selected uponI will achieve these ambitious goals by combining state-of-the-art thermal and sub-cellular physiology with intricate genomic techniques and powerful heritability analyses in captive and wild bird models – the endotherm group for which heat-induced mass mortality is most frequently reported. HotLife goes beyond the state-of-the-art, by i) bridging crucial knowledge gaps between heat failure in birds, its physiological basis, and its links to fitness and survival; ii) addressing the potential for rescue by plasticity or evolution f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Flexible InteligenT NEar-field Sensing Skins'.

assistant: **Concept**

The FITNESS project will realize flexible smart skins able to provide a non-contact sense of “touch”. The envisioned smart skins will operate at microwave frequencies, and the same device will also allow far-field communication. The key technology enabling these functionalities is that of metasurfaces, i.e. structured surfaces that have unusual properties at some frequencies. In this case, they convey and manipulate surface waves, which also can be turned into radiating leaky waves for far-field communications. The research follows a holistic and multidisciplinary concept targeting thin smart skins: the FITNESS project encompasses the synthesis of new low-loss flexible microwave substrates, research on the embedded electronics, the analysis and design of metasurfaces on curved structures and data analysis. The first demonstrator will be realized in the field of robotics, while later applications are envisioned in the medical area. Therefore, FITNESS will integrate ultra-low power operation from the beginning. The devices will essentially work through the measurement of the transmittance between a limited number of ports (sparse electronics), through surface waves following the shape of the smart skin which is wrapped around the robot or the body. The workpackages follow the main challenges toward the new technology: sparse, curved, integrated and flexible metasurfaces. One of the main societal outputs will consist of a more harmonious cooperation between robots and humans through the constant probing of their respective near-field environments.This ambitious 48-months 3.6 MEuros action gathers complementary key European experts from 4 EU countries, covering electromagnetics, electronics, materials, robotics, thermal aspects, but also the necessary skills for appropriate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'High Precision Micro Production Technologies' (HI-MICRO).

assistant: **Concept**

The Hi-Micro project intends to realise an innovative approach for the design, manufacturing and quality control of tool inserts to achieve significant breakthrough in mass production of precision 3D micro-parts, through further developing both enabling manufacturing technologies, including additive manufacturing (AM), micro electrical discharge machining (micro-EDM), micro electro-chemical machining (micro-ECM) and micro-milling, and unique metrology and quality control methods such as computer-tomography (CT) metrology and digital holography. Together with industrial technology providers, the Hi-Micro project will further bolster the performance of industrial equipment for mass production of precision 3D micro-parts, through modular design of tool insert units with improved thermal management capability, development of on-machine handling system and in-line quality control device. Activities will run over the entire value chain of mass production of precision 3D micro-parts, from product and tool insert design, manufacturing of tool inserts, micro injection moulding processes, to the production equipment and quality control in the whole production chain.In order to tackle the identified challenges and critical problems, the Hi-Micro project will provide radical innovations and major breakthroughs as follows:• Development of design and tolerance guidelines for advanced micro manufacturing of components (nominal size <1mm)• Reliable capability of manufacturing tool inserts with complex internal features for conformal thermal management in micro-injection moulding (μIM) and micro powder injection moulding (μPIM)• Processing technologies and equipment for manufacturing of 3D micro-parts with increased precision and accuracy to ensure smaller tolerances for the products,•
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for '3d modelling of resistivity logging imager' (3DRIM).

assistant: **Innovation**

In response to a global concern for more effective exploration and production of hydrocarbons, there is an absolute need to optimize operational costs and to limit the technical risks, associated to either health and safety or impact on the environment, leading to an increasing use of natural gas in Europe, gas being the cleanest fossil energy. As a result, more accurate evaluation of underground hydrocarbon reservoirs and gas storage facilities is needed. Formation evaluation aims at identifying and characterizing subsurface geological formations. This is generally done by measuring the rock properties with instruments (called logging tools) that are lowered in exploration wells. Of paramount importance are electrical resistivity measurements that are necessary to quantify the presence of hydrocarbons but also critical to provide key information on the dip, texture and structure around the borehole. Model1ing of the instruments' response in complex surroundings is an essential and critical part of the R&D process. Commercial 3D electromagnetic finite element programmes are not directly able to accurately model strong resistivity contrasts that can be found in potential hydrocarbon reservoirs. Specific programmes such ALAT 3D or SKYLINE developed by Schlumberger or 3D finite difference programmes developed by Delft TU (ET3D) or Texas University are extensively used to improve the performance of logging tools. However, these programmes are limited to DC measurements and to laterolog electrode-type tools. The research training area is the development of innovative techniques for efficient electromagnetic modeling since current approximations given by a DC model are no longer sufficient and improvement in the resolution of new borehole imagers requires modeling programmes
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Targeting TGF-β activation, likely the core mechanism of immunosuppression by human regulatory T cells.' (TARG-SUP) targeting Horizon 2020.

assistant: **Abstract**

Regulatory T lymphocytes (Tregs) inhibit immune responses and are required to maintain immune tolerance. Tregs express membrane protein GARP, which displays latent TGF-β1 on the cell surface. Immunosuppression by human Tregs appears to require GARP-mediated activation of TGF-β1.My objectives are to unravel the molecular aspects of TGF-β1 activation by GARP and determine the functional importance of this process in physiological and pathological conditions where Tregs or other GARP-expressing cells are present. As this implies the development of new tools to modulate GARP-dependent TGF-β1 activation and Treg immunosuppression, we will also explore their potential for the treatment of immune-related human diseases, and notably cancer.More specifically, I will:- Derive antibodies that modulate GARP-mediated TGF-β1 production by human Tregs and perform structural analyses in the presence of these antibodies to identify tri-dimensional changes in GARP/TGF-β1 complexes that lead to the release of active TGF-β1.- Identify and characterize additional proteins implicated in TGF-β1 activation by human Tregs, as GARP is required but not sufficient for TGF-β1 activation by Tregs. - Determine the immunological and clinical impact of inhibitory anti-GARP mAbs on cancer in mice. We will derive anti-murine GARP mAbs. As an alternative, we will generate mutant mice expressing a chimeric mouse/human GARP that is recognized by anti-human GARP mAbs. The antibodies will be tested in tumour-bearing mice treated or not with other immunotherapies including vaccines or immunostimulatory antibodies.- Determine whether blocking anti-GARP mAbs improve immune responses to microbial vaccines or to chronic infections, as these represent important applications for transient inhibition of Treg activity
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Measurement and Dielectric resonators for microwave communication systems' (1994-1998), addressing dissemination and exploitation.

assistant: **Impact**

Dielectric resonators are a small but essential component in modern mobile and satellite communication systems and their use will increase in line with growth in telecommunications. This co-operative research project will establish ways of characterizing and measuring dielectric resonators and analyzing their performance using computer modelling. Additional partners in Europe will be sought.