RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Incorporating in Numerical Schemes Transition On Curved Surfaces' under Seventh Framework.

assistant: **Concept**

This proposal deals with transition on curved surfaces and its modelling in Computational Fluid Dynamics (CFD) scheme. This research aims to develop the computational capability of the European Research Area (ERA) for subsonic transitional flows and to investigate the physics underlying the transition process in the presence of curvature effects. Towards these aims, the research objectives are (i) to generate a transition database with surface curvature under different free-stream turbulence levels, and based on the physics observed, (ii) to build a predictor model formulation that is compatible with present CFD approaches, which is physics-based rather than correlation-based and where variables such as effect of curvature and free-stream turbulence level can be tracked for simple flows. The results hoped for the project are to improve the ERA aerodynamic simulation tools through code modification and calibration and validation against high quality measurements; to provide physical insight on the mechanism of transition in presence of flow over curve surfaces; to advance the state-of-the-art where possible, and eventually, to provide means to develop strategies for the control of transition.The methodology is based on the combination of experimental, analytical and numerical techniques. The first step is to make an assessment of how curvature is taking into account or otherwise incurrent in transition model for computational fluids dynamics. Using a simple flow description where the effects of curvature can be studied analytically. Afterwards, a transition database with surface curvature under different level of free-stream turbulence level of flows of engineering interests will be generated using the existing wind tunnel at the University of Leicester with different me
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Towards FXR-mediated therapeutic intervention: Understanding how FXR integrates metabolic, endocrine and inflammatory signaling' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Nuclear receptors (NRs) are ligand-activated transcription factors that play vital roles in human physiology. 13% of all FDA-approved drugs target NRs, however they are associated with side-effects that limit their utility and safety. These side-effects are attributed to general activation of all NR transcriptional actions. Understanding the molecular mechanisms of NR transcriptional functions is essential to improve rational NR drug design. This project will focus on FXR, the NR activated by bile salts and key regulator of bile salt, lipid and glucose metabolism via transactivation. FXR also regulates inflammation status via transrepression of NF-κB. Currently, FXR is being investigated as target in the treatment of cholestasis, metabolic syndrome and inflammatory diseases. However, global activation of FXR will likely cause deleterious side-effects. Therefore, the proposed research aims to functionally dissect the different molecular mechanisms of FXR action during ligand-dependent transactivation and transrepression. Post-translational modifications and differentially recruited cofactors are crucial in differentiating between transactivation and transrepression.Key objectives:1.To investigate the upstream protein modifications in FXR both in vitro and in vivo models.2.To investigate protein-protein interactions that govern FXR signaling.Innovative unbiased assays that combine SILAC and biotinylated DNA-protein complex precipitations will be used to identify modifications and interacting proteins by mass spectrometry. In a pilot study, The Applicant identified a novel phosphorylation site (FXR-S224), important for gene transactivation but not NF-κB transrepression. These findings could advance drug design for FXR and warrant further investigation. During this fellowsh
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Phase coherence and other non-equilibrium properties of bose condensed atomic gases' (1994-1998).

assistant: **Concept**

Research objectives and content The research activity of the candidate will proceed in two directions: the first one closely related to the experiments aiming at Bose-Einstein condensation presently at work at ENS, the second one, assuming the condensate as starting point, addressed to the study of its coherence and non-equilibrium properties. Project objectives include: - Investigation of the physics of condensed atoms characterized by a negative s-wave collision scattering length. This situation should be in fact encountered in the ENS experiments where Cesium. atoms are used. Possible schemes to stabilize the condensate will be also considered. - Development of a theoretical treatment beyond the mean-field approach improving a method recently developed at ENS suitable to describe the dynamics of Bose condensates at very low temperatures. - Investigation of the properties of the condensate as an 'atom laser' i.e. a coherent source of atoms. Decoherence mechanisms induced by the interaction between particle will be studied. - Identification of a scheme to produce a continuous coherent source of atoms. - Investigation of the possibility to realize non-classical states for the atomic matter field. - Investigation of the situation in which two condensates are coherently coupled either by tunnelling of atoms between two condensates separated by a barrier, or by internal states transitions in the atoms of two condensates realized on two different internal states. Training content (objective, benefit and expected impact) The research activity of the candidate in a new and up-to-date field in a lively and outstanding scientific environment will provide her great benefit substantially enriching her research interests. Moreover her background in quantum optics could provide dif
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Molecular bases of programmed cell death in dictyostelium' under Fourth Framework.

assistant: **Concept**

Research objectives and content Programmed Cell Death (PCD) is crucial to animal development and tissue homeostasis. Several diseases involve dysregulation of PCD. Genes controlling PCD in vertebrates, nematodes and Drosophila have been isolated. The slime mould Dictyostelium represents the earliest known occurrence in eukaryotic evolution of PCD in multicellular development. Cells secrete DIF that contributes to induce part of the population to differentiate into dead stalk cells, supporting viablc spores. Certain PCD phenomena of stalk cell formation are similar to those in higher eukaryotes. This project will i.use genetic tractability of Dictyostelium to identify genes encoding molecules required for Dictyostelium PCD, ii. establish the precise function of these genes, and iii. investigate whether homologs of these genes have similar functions in higher eukaryotes. Training content (objective, benefit and expected impact) I will learn to apply, together with usual molecular biology techniques, a variety of up-to-date techniques such as tagged mutagenesis, confocal scanning laser microscopy, cell fractionation and enzyme assays, to identify and characterize genes and their cognate proteins involved in signal transduction and execution of PCD. The training allows me to pursue a career in fundamental or applied research, for example in the fields of developmental biology, cancer or AIDS. Links with industry / industrial relevance (22)
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Sheet hydroforming for the automotive industry' goes beyond current state-of-the-art under Fifth Framework.

assistant: **Innovation**

This project intends to develop sheet hydro forming for full-scale industrial application. The overall aim is to reduce the weight of the vehicles to support the reduction of CO2 emissions. The overall process development and optimisation is planned, starting from the choice of material, the preparation of sheets, process design and ends with the manufacture of two demonstrators, displaying the advantages of sheet hydro formed parts. Experimental and virtual procedures are considered as well as the process parameters and control systems. The link between experimental work and simulation is a key issue for the project in order to develop sheet hydro forming towards an industrial application, that fits into modern design and manufacture strategies. The project intends to promote the use of steel and aluminium by extending their forming limits using hydro forming process.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Maritime Intelligent Workplace for weather Information Network, Guidance and Supervision onboard ships', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

WINGS-FOR-SHIPS aims to develop, demonstrate and validate a new maritime intelligent workplace based weather information system and decision support for maritime transport and other applications. These will be realised by linking fixed/mobile communications with navigation/positioning, efficient transmission and delivery over the network as well geo-information. These services will allow the shipmaster to have seamless access to, and interaction with intelligent, customised (route based) rich content multimedia information on the efficient and safe navigation passage for passengers, freights and the environment both on board ship and inland. The new and intelligent approach in WINGS-FOR-SHIPS is a decision-support tool looking at forces and stresses on the ship as function of the local, accurate real-time weather information. Prediction models are also included for detailed estimation of weather parameters in local approach routes. The information is finally presented user-friendly in a familiar ECDIS digital chart on board ships, but also via Internet and WAP for shipmasters on land. WINGS-for-SHIPS will include an automatic system including dynamic calculations using ship and sea area models as well as real-time weather information.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Quantum Simulations of Relativistic Systems', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

This proposal is framed in the timely and novel field of quantum simulations of relativistic and quantum field theory systems. In the field of quantum information, quantum simulations of physical systems difficult to measure in the lab, with other, controllable, quantum systems, appear as one of the most promising avenues. Due to the difficulty to analyze some physical systems in the lab, or the limitations of classical simulations of quantum systems with standard computers, quantum simulations have raised much interest in the quantum information science. Simulating quantum relativistic systems with quantum optics setups, could shed much light on the fundamental properties of these relevant systems. In addition, it could establish interesting analogies and differences between the relativistic and the quantum optics systems, making a very multidisciplinary study. Prominent examples of already proposed scenarios are Dirac equation simulation in a single trapped ion, or black hole radiation in a Bose-Einstein condensate. Here, further interesting quantum relativistic systems, like Dirac fermions in interaction, quantum fields, exotic topological effects, or rotating and charged black holes, are proposed for their simulation in trapped ions, electrons in Penning traps, or cold atoms. Soon-to-be-made quantum simulations will already be able to overcome classical simulations with even the fastest classical supercomputers. Europe has maintained a leading position both in high energy physics and in quantum information, and this project will contribute to maintain this leadership from a modern and multidisciplinary approach.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Local for Local, Creating Economic Ecosystems Through NGI Deployment' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Reason why Local regions throughout Europe face shrinking economies, which threaten their ability to sustain small and medium enterprises (SMEs). Strong technological intervention aimed at strengthening local ties can revitalize these regions. At the same time, the European Next Generation Internet (NGI) initiative proposes a new internet of humans. It brings European values and norms to all citizens. We hold that NGI is the technological intervention needed to revitalize our regions.Project approach This project integrates open-source NGI building blocks into the Local for Local open-source software stack. We nurture a software ecosystem through open calls for NGI innovators, which we finance, supervise, mentor, and support in standardization. The selected top teams collaboratively create the envisioned software stack consisting of blockchain-based infrastructure, a modular platform, and one application called Locasus-B. The application is then tested in three pilots across five regions throughout Europe. We measure both the economic impact and the technical performance of the software stack. Results An open-source software ecosystem that collaboratively builds a software stack from NGI components. The attracted community of NGI innovators delivers the software stack as software common, which, being fully open source, can be extended by anyone who recognizes its potential. We deploy the software stack in five regions and use it to create self-sustaining socio-economic ecosystems. OutcomesThe direct outcomes of this project are economic validation and technical performance measurement of the software stack. These outcomes contribute to the adoption of the Digital Rights and Principles for the Digital Decade. We distribute building blocks that can create sustainable circ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The growth of galaxies', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Understanding how and why galaxies form and evolve is one of the most challenging problems in modern astronomy. Our own galaxy, the Milky Way, shows order and structure, as do most massive galaxies in our local neighbourhood. Yet when we look at very distant galaxies, which exist in the early Universe due to the time it takes their light to reach us, they are disordered and chaotic. Several theories suggest physical processes which may be responsible for this transformation, but we lack conclusive observational evidence.The last two decades has seen an enormous increase in the quantity of data on both local and distant galaxies. In the next 3 years several new surveys will be completed, providing better spatial resolution and wavelength coverage of distant galaxies than ever before. Examples are the Hubble CANDELS survey and UltraVISTA with the new European survey telescope. However, the last decade has shown that our understanding of galaxies does not necessarily advance as rapidly as data quantity and quality. The development of sophisticated methods to compare theories of galaxy evolution to observational data is urgently needed before these new surveys can be fully exploited and we can irrefutably identify the dominant physical processes driving galaxy evolution.Since the completion of my PhD in observational galaxy evolution in the UK, I have gained 5 years of experience in France and Germany in interpreting galaxy survey data with models. I have built a unique network of collaborators and range of expertise which I will bring to a focus studying high redshift galaxy evolution in my new position at the University of Edinburgh. This project will naturally join European teams with expertise in data and models. As well as ensuring that Europe continues to lead the way
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Natural sensory feedback for phantom limb pain modulation and therapy'.

assistant: **Concept**

Amputation of a limb may result from trauma or surgical intervention. The amputation traumatically alters the body image, but often leaves sensations that refer to the missing body part. In 50-80% amputees, neuropathic pain develops, also called phantom limb pain (PLP). Both peripheral and central nervous system factors have been implicated as determinants of PLP. Also, PLP may be triggered by physical (changes in the weather) and psychological factors (emotional stress). Recent evidence suggests that PLP may be intricately related to neuroplastic changes in the cortex, and that these changes may modulated by providing sensory input to the stump or amputation zone. However, the understanding of why PLP occurs is still poor, the basic research results have not been tested on a large scale in the clinic, and there are no fully effective, long-term treatments readily available on the market. We aim to challenge the status-quo of PLP therapy by offering technological solutions that will invasively or non-invasively induce natural, meaningful sensations to the amputee to restore the neuroplastic changes in the cortex and thereby control and alleviate PLP. We will assess the effect of cortical neuroplastic, psychological and cognitive components of pain and integrate the knowledge into clinical guidelines. The proposed work directly targets the HEALTH.2013.2.2.1-5 topic. The consortium will build solutions based on existing technologies emerging from previous EU funded research which are presently only available in experimental settings. We believe that implementation of proposed work will be the cornerstone needed to exploit, validate and translate the basic research results into clinical applications and provide long-term, patient-specific solutions to a large group of pati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Efficient CFD Multi-physics programming research' (E-CFD-GPU), addressing dissemination and exploitation.

assistant: **Impact**

The current evolution in the aeronautical field towards high-fidelity simulations, including multi-physics and more reliable modeling of turbulence and transition, calls for a new approach of the complete CFD-multi-physics simulation chain, with a drastic reduction of its turnaround time.This requires revising the whole CAE chain,  from pre-processing (CAD handling and mesh generation), to very fast basic CFD algorithms and to efficient, full parallel post-processing, in order to achieve a reduction of the global turn-around time by several orders of magnitude.On a shorter term, of 24 months of the current CfP project, the following objectives can be ensured, based on very recent developments performed at NUMECA Int.:•A gain of one order of magnitude at the pre-processing level, covering automatic CAD cleaning, wrapping and parallel unstructured grid generation for arbitrary complex configurations with the software system HEXPRESS™/Hybrid.•A gain of one order of magnitude, due to a novel convergence acceleration algorithm, allowing calculations with CFL=1000 and convergence of steady state RANS simulations, in 50 multigrid cycles.The present proposal has as objective to respond to the CfP topic by•extending these capabilities to the GRA-LNC configurations•extending the convergence acceleration methodology to simulations with laminar-turbulent transition, and to unsteady flows•providing guidelines for a next generation software environment for industrial aerodynamics simulation, in response to task 2 of the CfP,•porting of the CFD code and the convergence acceleration algorithms to GPU’s, with an expected additional gain of 1 to 2 orders of magnitude.One could therefore expect, combining the above mentioned efforts that within the framework of the project duration, a gai