RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Elucidating the role of Arid1a in adult liver' (EPILIPRO).

assistant: **Innovation**

Liver cancer is the fifth most common malignancy in men and the eighth in women worldwide. Of note, liver cancer is tightly associated with tissue damage due to the high metabolic and drug detoxification activity of the liver. Increasing evidence demonstrates that toxic agents induce the activation of a resident ductal-progenitor population capable of regenerating the tissue. Therefore, understanding molecular mechanisms governing liver progenitor cells is essential for preventing tumour initiation and progression. The aim of this proposal is elucidating the role of Arid1A (the DNA-binding subunit of the nucleosome-remodelling complex SWI/SNF) in adult liver progenitors by using novel 3D-organoid cultures, which allows long-term expansion of adult ductal-progenitors derived from the healthy liver. Moreover, genome-wide analysis and in vivo approaches will be implemented for accomplishing the goals of the project. Supporting a crucial role for Arid1a in liver progenitors, Arid1a expression is high in organoid cultures and is up-regulated in the adult liver upon damage as compared to the healthy liver. Importantly, Arid1a and other SWI/SNF subunits are mutated in liver cancer, suggesting that Arid1a and SWI/SNF exert a tumour suppression function. In line with this, our preliminary results indicate that depletion of Arid1a and SWI/SNF components increases organoid formation efficiency. Overall, this research plan will shed light on the function of Arid1a and the SWI/SNF nucleosome-remodelling complex in adult liver progenitors and mouse liver regeneration, providing novel hints into their role in carcinogenesis.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'BRIDGING THE TIMESCALES IN FAULT-SLIP ACCUMULATION: FROM THE EARTHQUAKE RECORD TO THE GEOLOGICAL RECORD' (BRIDGSEISMTIME) targeting Seventh Framework.

assistant: **Abstract**

Natural hazards, earthquakes in particular, can have a significant impact on the economic vitality of European regions. An improved understanding of seismic risk can help minimize the loss of human life and resources during extreme seismic events. This proposal aims to investigate the development of faults in the Earth’s crust and to improve the current understanding of earthquake behavior on timescales ranging from individual earthquakes to millions of years. Faults are breaks in the Earth's crust that grow due to slip caused by earthquakes. However, the slip accumulation on faults during successive earthquakes and the patterns arising from this process are poorly understood, mainly due to the brevity of the available earthquake record. The proposed research will employ an interdisciplinary approach that combines geological and geophysical data, geostatistical tools and numerical models to improve our understanding of earthquake occurrence on faults. The major axes of this approach will involve the acquisition, geostatistical analysis and simulation of fault-slip measured from seismic catalogues, paleoearthquake investigations and surface/subsurface geology. Collectively, the data will span timescales of days to millions of years. The objectives will be accomplished by analyzing and combing the statistics of 1792 slip/time measurements from a global dataset of faults located in 6 fault systems. The dataset will be augmented by new field measurements collected from faults in New Zealand using fault-trenching and outcrop geology. Geostatistical analysis of the fault-slip histories will be performed independently for different timescale-data in order to measure their individual earthquake statistical properties. The results will be subsequently merged using Bayesian stati
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Pbx proteins as pioneer factors promoting signal specificity in mesodermal differentiation' in the context of a Horizon 2020 call.

assistant: **Objectives**

The development of healthy organisms requires the formation of different cellular systems, such as a blood, bone and muscle. All these different cell types arise during embryonic life from specific pools of mesodermal progenitors (MPs). A central question is how distinct MPs are specified and ultimately why different cells respond to signalling pathways in different ways? Critical insights here are directly relevant to conceive strategies for increasing the efficiency of mesodermal differentiation aimed for treating muscular degenerative diseases. To date, in vitro, somitic mesoderm differentiation for regenerative purpose has had limited success. Wnt signalling promotes Embryonic Stem Cell (ESC) differentiation of all the MPs, including skeletal muscles. The activity of specific pioneer transcription factors (TFs) may be the key for converting Wnt signalling pathways into a specific transcriptional program. Pioneer TFs shape the chromatin landscape by opening the chromatin and allowing the recruitment of lineage specific TFs, and thus ultimately control the TF binding dynamics and the acquisition of a specific cell fate. Pbx proteins are pioneer TFs, which are specifically expressed in the primitive streak, the region of the embryo that will produce all mesoderm, and are critical for promoting mesodermal specification. Here, I will establish how Pbx proteins specify MPs and determine the competence of early mesoderm to respond to Wnt signalling. To this end, I will use mouse embryos and murine epiblast stem cells, which are analogous to human ESC (hESCs). My approach combines the strength of an in vitro ESC differentiation method, routinely used at DanStem, with chromatin immunoprecipitation and transcriptional regulation assays, which I have extensively mastered durin
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'DAREED – Decision support Advisor for innovative business models and useR engagement for smart Energy Efficient Districts'.

assistant: **Innovation**

DAREED aims at delivering an ICT service platform (and some specific tools) to foster energy efficiency and low carbon activities at neighbourhood, city and district level. Project results will be validated via pilots in three (3) different countries and contexts, thus granting the possibility to generalise results and ensuring replicability throughout Europe and beyond.The key success factor for effective energy efficiency initiatives at community level is to involve all the stakeholders who have active role in decision making and provide them the right information at the right time to take informed decisions; to this extent, user engagement through social networks can foster participation and energy consumption awareness. Stakeholders (i.e. citizens, household landlords, public spaces managers and urban planners) need tools and information to understand and assess alternatives to traditional consumptions patterns and inertial behaviours leading to high consumption levels. Energy providers need information and tools to implement business models oriented to energy service proposition oriented to a sustainable consumption model.There is need to go beyond acting on energy consumptions under direct control to understand ex-ante savings that can be achieved through energy efficiency related measures, management tools, and new services and implement them along with the related cost/benefit ratio. Although regulations about buildings, infrastructures and public spaces are fostering the implementation of important energy efficiency measures, a major driver for the change are the actual economic saving for users obtained from energy efficiency based business models. The service-oriented approach of the platform will allow easy adoption, overcoming technological, financial and k
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Physical Activity, Inflammation and Respiratory health: an integrative analysis of biological, behavioural and environmental determinants' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

The link between physical activity with respiratory health and chronic obstructive pulmonary disease (COPD) remains weak and under-investigated. The limited existing research seems to suggest that systemic inflammation could lie in the causal pathway of this relationship, and that inflammatory-related conditions may modify this potential causal mechanism, although these hypotheses remain largely understudied. This project will investigate 1) the effect of physical activity on lung function decline and COPD incidence in European adults, as well as 2) the mediating role of systemic inflammation and 3) the influence of biological (BMI, co-existing chronic inflammatory diseases), behavioural (diet, smoking) and environmental (air pollution, greenness, ultraviolet radiation) factors on this relationship. Data from over 18,000 subjects from 3 large population-based adult cohorts (ECHRS, SAPALDIA and NFBC), for which data on lung function and physical activity were prospectively collected during at least two follow-ups approximately a decade apart, will be included. Lung function was measured by spirometry according to international standards. Physical activity frequency, duration and type was collected using self-reported (ECRHS and NFBC) or interviewer-administered (SAPALDIA) questionnaires. Systemic inflammation will be assessed using C-reactive protein and interleukin-6 levels in serum. Data on the inflammation-related factors of interest were collected by the cohorts or derived from previous/ongoing collaborations. Cross-sectional and longitudinal associations, and potential interactive effects, will be examined by centre/cohort and combined estimates will be derived.Given that lung function is an important determinant of health and that physical activity is one of a very
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Tissue engineered nerve repair devices: development of european medical implantable devices and research training focus.', explaining its relevance to EU policy priorities under Fifth Framework.

assistant: **Impact**

Why are there still no effective protocols for repairing the damaged nervous system? Our proposal addresses this question and: will link basic scientists and clinicians working in the fields of the and nerve repair with expertise in complementary technologies and well characterises experimental systems; produce and test fibronectin-based materials for use as implants in nerve repair; identify a quantitative relationship between mechanical load and adhesion in repaired peripheral nerves; develop devices for use when stretch-induced fibrosis is a major problem in nerve repair, such as the use of hyaluronan barrier layers. Assess the potential of fn -based material to support axonal regrowth in thes cns; train young european scientists and clinicians in experimental and clinical research methodologies; generate novel treatment strategies for nerve repair.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'DualDur: A Disruptive Diagnostic Technology that Enables for the First Time an Early and Accurate Diagnosis of the tick-borne Lyme Disease.' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Lyme borreliosis (LB) is the most common zoonotic disease in Europe with 650-850,000 estimated cases. Currently used serological tests for Lyme disease are highly unreliable in early stages of the infection, showing 17-40% sensitivity. If the disease is not diagnosed and treated early on; the infection often spreads to joints, the nervous system, and the heart causing severe and potentially persisting symptoms. Late stage, disseminated LB is a heavy burden on the patients in terms of quality of life and direct and indirect costs. It is also a significant burden on the European healthcare system: the majority of the €1 billion annual cost of the disease is associated with late stage LB. Our patented DualDur reagent and method enables a more reliable early diagnosis of Lyme disease than currently used serological methods, as it is based on direct detection of the bacteria and does not rely on the immune response. So far used as a supplementary testing method mainly at research institutes, in the present project we aim to validate a novel testing procedure based on software-aided microscopy. This will allow the wide-spread application of DualDur, as it improves time-to-result by 10 times, and decreases personnel need compared to our current procedure. Our improved reagent and software-aided testing enables us to provide the DualDur tests all over Europe through partnerships with medical laboratories. More reliable early diagnosis of Lyme disease will reduce the number of later stage cases significantly. This in turn will improve the quality of life of patients and reduce the financial burden of the disease, saving approximately € 330 million on healthcare costs in the first 5 years already. DualDur testing targets the €400 million European Lyme diagnostic market. We will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'The Value of Renewable electricity: part 2' under Fourth Framework.

assistant: **Concept**

RE-VALUE 2 - PROJECT SUMMARY RE-VALUE 1 has shown that renewable electricity generally does add value to an electricity system and that the value is made up of a number of site specific benefits and avoided costs, including the universally accepted costs of fuel saved. It has illuminated the need for studies which examine all the constituents of value from a site-specific power plant. Moreover, it has become clear that a key problem for renewable electricity Generators is that there is often no formal mechanism within the electricity system to pay the renewable energy Generator for the added value. This skews the incentives within the electricity system against the use of embedded renewable generation. It is therefore important that the economics of embedded generation are incorporated in to the support, regulatory and tariff mechanisms of electricity systems. The goal of RE-VALUE 2 is therefore to take the issues of RE-VALUE 1 a stage further: 1. RE-VALUE 2 will provide over 20 detailed studies of the value that wind, hydro, biomass, landfill gas and photovoltaic energy projects brings to the electricity system in seven countries, based on the methodology used by Pacific Gas and Electric (PG&E) in a study of a photovoltaic project, modified to suit European circumstances. It will: 1.1 evaluate the costs and benefits of over 20 projects to the electricity system; 1.2 evaluate the effect on the electricity system in terms of reliability and reinforcement; 1.3 consider how these costs and benefits change with very large penetrations of renewable electricity generation, for example greater than 10 per cent of supply. 2. RE-VALUE 2 will provide the specification for easy-to-use off-the-shelf methods and models for calculating the value of renewable electricity. 3. RE-VALUE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of a reliable quality control system using advanced Non-Destructive Evaluation (NDE) technologies for the production environment of leak-free fuel tanks from plastics and composites' (NDE) targeting Horizon 2020.

assistant: **Abstract**

Nowadays, the usage of Plastic Fuel Tanks (PFTs) has dominated over steel tanks as they offer numerous advantages such as lower weight, higher corrosion resistance, better crash performance and lower total systems costs. Tank manufacturing from plastics and composites in automotive sector is increasingly adapted to mass productions to meet the ever growing demand. The management of quality control (QC) systems for factory environment poses challenges in the absence of relevant experience in the development and use of in-situ non-destructive evaluation (NDE) technologies. The problem currently faced by the automotive industry is that most techniques that fall within the accepted leak detection sensitivity requirements are based on manual intensive and operator-dependent tasks. Leak detection techniques with higher sensitivity do exist; however they are characterized by high investment and operational costs. Hence, their implementation is not economically feasible as the related costs outweigh their benefits for the automotive QC purposes.The LeakFree project targets at bringing to the market a low cost leak detection system that is fast, accurate, traceable and automated for mass production environments in the fuel tanks production industry. The system eliminates the disadvantages associated with the manual-intensive and operator-dependent techniques, currently employed by the industry, through the development of an inspection technique based on Acoustic Emission (AE). The LeakFree acoustic technology has already been demonstrated in fuel-tank production environment and the project targets at bringing the system to the market. The activities to be performed span from design and prototyping to validation, demonstration, performance verification and standards certification
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'GoJelly - A gelatinous solution to plastic pollution' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The objective of the GoJelly project is to develop, test and promote a gelatinous solution to microplastic pollution by developing a TRL 5-6 prototype microplastics filter (GoJelly) for commercial and public use, where the main raw material is jellyfish mucus. In doing so, the consortium addresses two environmental issues with one approach by removing the commercially and ecologically destructive sea and coastal pollution of both jellyfish and microplastics. This innovative approach will ultimately lead to less plastic in the ocean, municipal demand (and thereby competitive prices) for jellyfish raw material to fill the ""mucus-need"" by filter developers, and in turn more jobs for commercial fishers in off-seasons. The by-products of the GoJelly biomass have other uses as well, ensuring that GoJelly also delivers a green innovation, resulting in novel, valuable resource for the food and feed industry as well as agro-biological fertilizer for organic farming. The GoJelly prototype products will be tested and demonstrated in three different European seas (Norwegian, Baltic and Mediterranean), by a range of stakeholders, including commercial fishers and industry partners. Tying it together, the project will also ensure the possibilities for broader European promotion and utilization of GoJelly at the local, regional and global level by delivering a socio-ecological methodological toolbox for forming and implementing policies. GoJelly will broadly communicate its results in several formats such as traditional social media, open lab ship cruise, and in the form of an experimental online game depicting different management scenarios under different jellyfish- and microplastics combinations. An interdisciplinary and international consortium consisting of technology developers