RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Treatment of liver disease and cancer prevention' (PRELICAN) under Horizon 2020.

assistant: **Objectives**

Advanced liver disease and cancer is the only major cause of death still increasing each year. Major causes include hepatitis B and C viruses, alcohol and non-alcoholic fatty liver disease/steatohepatitis (NAFLD/NASH). A major contributing factor to the increasing incidence and mortality of liver disease is the staggering rise in obesity. The absence of effective therapeutic options for NAFLD/NASH, advanced liver disease and cancer contribute to the poor prognosis and the high cost associated with patient care. We have established a tractable and clinically relevant human cell-based model system in which viral infection, ethanol or free fatty acids induce a clinical gene expression signature robustly predicting liver disease progression and long-term HCC risk in cirrhotic patients. Using this model we identified compounds as HCC chemopreventive agents. Aiming to evaluate these compounds for future clinical development and potential commercialization we will perform proof-of-concept studies in state-of-the-art mouse models for NASH and hepatocarcinogenesis. Specifically we will assess the therapeutic effect on liver inflammation, steatosis, fibrosis and HCC development and investigate its safety in long-term administration. With the completion of this program we expect to obtain a robust proof-of-concept data package as a first- or best-in-class compound for treatment of chronic liver disease and prevention of HCC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Architecture for EurOpean Logistics Information eXchange' (AEOLIX), addressing dissemination and exploitation.

assistant: **Impact**

Supply chain visibility supported by easy access to, and exchange and use of relevant and abundant logistics-related information is an important prerequisite for the deployment of pan-European logistics solutions that are needed to increase efficiency and productivity, and to reduce environmental impact. Although there is a proliferative development of logistics-related data stores, information channels, information management systems and data mining facilities, with both international and intermodal focus, this multitude of solutions exhibits a high degree of fragmentation, due to differences in user requirements, data models, system specification and business models. This legacy situation severely hampers the optimal use of logistics-related information. To overcome this fragmentation and lack of connectivity of ICT-based information systems for logistics decision making, AEOLIX will establish a cloud-based collaborative logistics ecosystem for configuring and managing (logistics-related) information pipelines. This digital business ecosystem will create visibility across the supply chain, enabling more sustainable and efficient transport of goods cross Europe. An essential element of the approach is to ensure that for logistics actors connecting to and using the ecosystem in undemanding and has a low level of complexity.  We envision the ecosystem enabling the integration of supply-chain-related transport business processes through logistics software solutions for cloud-based connectivity and interaction, in order to support more efficient collaboration in the logistics supply chain than exists today. By enabling low-complexity and low cost connectivity of local ICT platforms and systems and thereby scalable, trusted and secure exchange of information, AEOLIX will im
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Rational production and improved working environment through using self compacting concrete'.

assistant: **Objectives**

Practically all concretes currently used in housing and Practically all concretes currently used in housing and Practically all concretes currently used in housing and civil engineering construction requires compaction to achieve their required strength and durability. The prevailing method for compaction is by vibration of the freshly placed concrete. Yet for different reasons, vibration generates delays and overcosts in projects. Moreover it is a serious source of health hazard on and around construction sites. The main goal of the project is to develop a new vibration free production system to lower the overall cost (including technical and social costs) of in situ cast concrete construction. The project is subdivided in two parts: The first part concerns the development of two new types of concrete as follows: * very fluid concrete called Self Compacting Concrete (SCC). Thanks to recent developments in concrete technology, such SCCs are feasible. The project will focus on their mix design process, taking into account the properties of the local materials. It will then be possible to control the properties of the SCC at the fresh and the hardened stage and to minimise the cost of producing them. * Steel Fibre Reinforced Self Compacting Concrete (SFR SCC) where steel fibres will substitute for part of the conventional reinforcement.  The second part deals with full scale experiments in civil engineering and housing. The main target here is to develop production and transport methods suitable for SCC and to optimise construction site organization to achieve more competitive production and construction costs. The use of SCC will: promote the development of a more rational concrete production accelerate the construction process significantly reduce the technical cost of
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Unravelling the mechanism of nuclear transport using optical nanopores' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The nuclear pore complex (NPC) is the gatekeeper of the nucleus that regulates the flow of all molecules across the nuclear envelope. Remarkably, this ~40 nm wide pore is capable of efficient and fast transport while remaining highly selective. Its dense central channel is composed of a highly dynamic spaghetti-like mesh of intrinsically disordered proteins that allows small molecules to pass freely, whereas large macromolecules (>40 kDa) rely on specific transporter proteins that ferry their cargo across the pore. Even though various models have been proposed, the fundamental biophysical mechanism of nuclear transport and of the selectivity of the NPC has not been resolved yet. One of the main reasons that have hindered our progress in understanding nuclear transport is the lack of experimental techniques that can probe the structure and dynamics of the disordered proteins and transport receptors inside the NPC channel and during transport with sufficient spatiotemporal resolution. In the proposed action, I aim to establish a modifiable biomimetic platform for single-molecule investigations of nuclear transport. This interdisciplinary and innovative approach combines solid-state nanopores, coated with disordered proteins to mimic the nuclear pore, with optical detection in zero-mode waveguides and DNA origami nanotechnology. The proposed experiments will allow to monitor the translocation of single fluorescently labelled molecules through biomimetic NPCs with excellent sensitivity and specificity. I will use this platform to elucidate the biophysical principles that underlie the structure and selectivity of the NPC channel and the mechanism of active nuclear transport. The direct insights on the single-molecule level obtained by the results of this project will be cruc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Brain-wide processing and whole-body biophysics of directional sound'.

assistant: **Concept**

Locating sound sources such as prey or predators is critical for survival in many vertebrates. Terrestrial vertebrates achieve this by measuring the time delay and amplitude difference of sound waves arriving on each ear. For fish however, the faster speed of sound in water and the proximity of the two ears make such cues useless. Yet, directional hearing has been confirmed behaviorally, and the mechanisms have puzzled researchers for decades. Theoretical studies attempted to explain this remarkable ability, proposing that acoustic pressure and particle velocity signals must be measured separately and then be compared. However, the locus of this computation is unknown and its neuronal and biophysical mechanisms remain obscure. This is because most vertebrate brains and inner ears are highly opaque, rendering them inaccessible to systemic optical investigation. Addressing this challenge, we recently identified the teleost Danionella translucida (DT) as a unique vertebrate model for neuroscience. DT are among the smallest living vertebrates and are transparent throughout their lifespan. Despite having the smallest known vertebrate brain, they display a rich set of complex behaviors, including acoustic communication, illustrating the ethological relevance of hearing for this species. Building on our experience with acoustics and brain-wide imaging, we will exploit this model to (1) image the vibrational response of the inner ear, (2) study the neuronal activity of the sensory epithelia, and (3) follow the neuronal integration of sensory signals by circuits across the brain with functional imaging. These measurements will, for the first time, allow us to study the entire acoustic processing chain from acoustic stimulus, via mechanical transmission, to brain-wide neuronal in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Structural basis of controlling the membrane attack complex' (2014-2020), addressing dissemination and exploitation.

assistant: **Impact**

Structural basis of controlling the membrane attack complexComplement is a fundamental component of the human immune system; central to the battle between hosts and pathogens. The membrane attack complex (MAC) is the direct killing arm of complement that acts by forming large pores in target cell membranes. Uncontrolled activation results in by-stander damage, which can have devastating consequences for host cells and impact inflammatory pathologies, thrombosis and cancer. Understanding how MAC activity is controlled on human cells during an immune response is a major unresolved question.My lab has pioneered the use of cryo electron microscopy (cryoEM) to investigate the molecular mechanism underpinning MAC assembly. We have defined the stoichiometry of the complex and identified interaction interfaces that determine its sequential assembly mechanism. Recent data from my lab has now revealed atomic resolution information for the complete transmembrane pore. Results from my lab have provided a molecular and biophysical basis for MAC pore formation, which has led to a general mechanism for how proteins cross lipid bilayers.Here, the goal is to understand the structural basis for how MAC activity is controlled by (i) cell surface receptor CD59, (ii) removal of pores from the plasma membrane, and (iii) clearance of assembly by-products from the plasma. MAC interacts with a defined set of cellular proteins through these three pathways. In this proposal, we will integrate structural information that spans cellular to molecular length scales. Recent technical advances in cryoEM, cryo soft X-ray tomography (cryoSXT) and correlated fluorescence imaging make it now possible to address how MAC activity is controlled in and around the plasma membrane. In doing so, we will answer a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Traditional Chinese Medicine in the Post-genomic era: identifying lead therapeutic compounds against cancer'.

assistant: **Concept**

This application aims at identifying and characterizing a set of lead therapeutic compounds against cancer (breast, lung and brain), based on current knowledge from Traditional Chinese Medicine (TCM). TCM has a very long tradition in the prevention and treatment of a variety of diseases yet, in contrast to target-oriented Western medicine, TCM uses a holistic and synergistic approach, which can be very effective for complex medical problems. However, the exact composition of the compounds that exert the therapeutic effect is not known. As there is little understanding about the mechanisms of action of many TCM therapies, modern and multidisciplinary Biotech research (functional genomics/ systems biology) should be applied on appropriate and highly defined cancer models. The presented project will focus on the isolation and characterization of chemical compounds from TCM that show anti-tumoral efficacy. From a library of therapeutic compounds available, a set of lead therapeutic substances will be identified using high throughput screening technologies in appropriate preclinical cancer models. Moreover, their mechanism of action will be further studied using genome wide analyses. Finally, their therapeutic efficacy will be tested in appropriate animal models.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Towards a better sunlight to biomass conversion efficiency in microalgae' (SUNBIOPATH).

assistant: **Concept**

SUNBIOPATH - towards a better sunlight to biomass conversion efficiency in microalgae - is an integrated program of research aimed at improving biomass yields and valorisation of biomass for two Chlorophycean photosynthetic microalgae, Chlamydomonas reinhardtii and Dunaliella salina. Biomass yields will be improved at the level of primary processes that occur in the chloroplasts (photochemistry and sunlight capture by the light harvesting complexes) and in the cell (biochemical pathways and signalling mechanisms that influence ATP synthesis). Optimal growth of the engineered microalgae will be determined in photobioreactors, and biomass yields will be tested using a scale up approach in photobioreactors of different sizes (up to 250 L), some of which being designed and built during SUNBIOPATH. Biomethane production will be evaluated. Compared to other biofuels, biomethane is attractive because the yield of biomass to fuel conversion is higher. Valorisation of biomass will also be achieved through the production of biologicals. Significant progress has been made in the development of chloroplast genetic engineering in microalgae such as Chlamydomonas, however the commercial exploitation of this technology still requires additional research. SUNBIOPATH will address the problem of maximising transgenic expression in the chloroplast and will develop a robust system for chloroplast metabolic engineering by developing methodologies such as inducible expression and trans-operon expression. A techno economic analysis will be made to evaluate the feasibility of using these algae for the purposes proposed (biologicals production in the chloroplast and/or biomethane production) taking into account their role in CO2 mitigation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Democratic Responsiveness in Comparative Perspective: How Do Democratic Governments Respond to Different Expressions of Public Opinion?' to be submitted under Seventh Framework.

assistant: **Abstract**

To what extent are democratic governments responsive to citizens’ demands and preferences between elections? Are governments more likely to be responsive to the interpretation of public opinion through surveys or to collective and publicly expressed opinion –generally in the form of protests? When does one ore the other type of expression prevail as a mechanism to foster governmental responsiveness? What happens when both forms of expression of the public mood are in clear contradiction? Are certain institutional and political configurations more likely to make governments more responsive to citizens’ views between elections? Are certain political configurations more conducive to governments paying attention to opinion polls while others make them more receptive to collective action claims-making? This project will answer these questions by developing a comparative study of of governmental responsiveness in established democracies between 1980 and 2010. To this purpose, we will discuss the relevant definitions of ‘governmental responsiveness’ and ‘public opinion’, and analyse data from various sources: (i) public opinion surveys, (ii) datasets with information on protest events, (iii) news reports on public moods, collective action, and governmental activity and decision-making, and (iv) comparative indicators on institutional attributes of democratic systems. In terms of the research strategy, the project will combine the analysis of a large number of cases (20 established democracies) with a more detailed study of a set of up to 7 cases. This study will provide a highly innovative approach to the representative link between citizens and governments by comparing the dynamics of democratic representation in decision-making junctures in the periods between elections for
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Stay on market' (1994-1998) under Fourth Framework.

assistant: **Objectives**

- That the OCR under development can readily perform static image acquisition; it is simple and reliable and its production price can be very competitive in comparison with already available similar devices.- That the ASIC itself can be profitably used in other planned products that require image analysis, such as a surveillance TV camera or a digital remote TV camera connected to the control monitor via a telephone line.- The acquired microelectronic experience is to be transferred to other products, leading to enhanced performance and substantial savings in production cost.A dedicated, compact and cost-effective TV camera is to be designed for use in an Optical Character Recognition (OCR) subsystem as well as in a remote surveillance system. It must therefore be capable of performing pattern recognition and motion detection functions. ASIC technology has been selected to achieve the best price-to-performance ratio. Most of the image analysis functions are performed by the ASIC now in development and the complete system just requires few very low cost components other than the microprogrammable ASIC itself to do the required job.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Reproductive decision-making in a macro-micro perspective' (REPRO) targeting Seventh Framework.

assistant: **Abstract**

The main objective of the REPRO project is to upgrade the existing knowledge and to generate new scientific and policy-oriented knowledge on the factors that drive changes in the birth rates and influence the reproductive decision-making of contemporary Europeans. REPRO incorporates analyses in macro, micro, and macro-micro perspectives. At the macro level, we describe recent fertility trends observed across Europe and examine their association with selected macro-level social, economic and institutional indicators. At the micro level we use the social-psychological theory of planned behaviour to analyse the process of reproductive decision-making. The theory will be developed to fit specific demographic research on fertility intentions of individuals as well as of couples. We also use panel data to obtain insights into the realisation or non-realisation of fertility intentions. To this end, we make use of economic, sociological, and cultural theoretical approaches whose application has proved useful. The analyses at the micro-level are furthered by inferences based on available qualitative surveys. The macro-micro approach integrates the findings reached at the macro and at the micro level using comparable data sets on fertility intentions and behaviours available in most European countries and multi-level statistical techniques. This integrated approach sheds light on the impact and interrelatedness of diverse factors such as work patterns and employment, family formation, housing, gender roles and factors related to ideational change, cultural specifics and institutional settings. Finally, the integrated method of research generates knowledge that can be streamed into relevant policy construction and implementation. A synthesis of all findings will be performed to se