RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'The Analytic Conformal Bootstrap' (ACB).

assistant: **Innovation**

The aim of the present proposal is to establish a research team developing and exploiting innovative techniques to study conformal field theories (CFT) analytically. Our approach does not rely on a Lagrangian description but on symmetries and consistency conditions. As such it applies to any CFT, offering a unified framework to study generic CFTs analytically. The initial implementation of this program has already led to striking new results and insights for both Lagrangian and non-Lagrangian CFTs.The overarching aims of my team will be: To develop an analytic bootstrap program for CFTs in general dimensions; to complement these techniques with more traditional methods and develop a systematic machinery to obtain analytic results for generic CFTs; and to use these results to gain new insights into the mathematical structure of the space of quantum field theories. The proposal will bring together researchers from different areas. The objectives in brief are:1) Develop an alternative to Feynman diagram computations for Lagrangian CFTs.2) Develop a machinery to compute loops for QFT on AdS, with and without gravity.3) Develop an analytic approach to non-perturbative N=4 SYM and other CFTs. 4) Determine the space of all CFTs.5) Gain new insights into the mathematical structure of the space of quantum field theories. The outputs of this proposal will include a new way of doing perturbative computations based on symmetries; a constructive derivation of the AdS/CFT duality; new analytic techniques to attack strongly coupled systems and invaluable new lessons about the space of CFTs and QFTs.Success in this research will lead to a completely new, unified way to view and solve CFTs, with a huge impact on several branches of physics and mathematics.


**Keywords:** Conformal Fiel
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Biomarker Enterprise to Attack DKD - Sofia ref.: 115974', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Diabetic kidney disease (DKD) is the leading cause of end stage renal disease (ESRD), and its global incidence and prevalence have reached epidemic dimensions in recent years. Unfortunately, there are no effective means to prevent or cure DKD, the few existing treatments have limited effect and very few alternative therapies have emerged in the past years. Lack of new predictive and prognostic biomarkers for a more accurate patient stratification, limited access to kidney tissue from patients at various stages of DKD as well as novel model systems to better understand the pathogenesis of the disease, are likely reasons for the stagnating development of new treatments.The BEAt-DKD consortium combines outstanding basic and translational researchers in nephropathy, diabetes, kidney model systems, imaging techniques and systems biology, and includes leaders of diabetes and kidney disease-relevantIMI1, FP7 and US consortia, like SUMMIT, KIDNEYCONNECT, Syskid, CPROBE and C-Path, in an unprecedented search for new and better biomarkers for DKD, through a better understanding of the disease.Jointly, the partners have access to vast and very relevant clinical cohorts and trials, state-of-the-art analysis and imaging techniques, novel model systems and the long-standing experience and networks to make this collaboration a success. By involving regulatory agencies throughout the project, BEAt-DKD aims at making the introduction and acceptance of new tools as efficient as possible.The overall goals of BEAt-DKD are (1) to provide a holistic systems medicine view of the pathogenesis of DKD with the aim to identify targetable mechanisms and pathways underlying initiation and progression of DKD, applying a novel sub-classification of diabetes, and (2) to identify and validate biomarker
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Unravelling and exploiting Mediterranean Sea microbial diversity and ecology for Xenobiotics’ and pollutants’ clean up' in the context of a Seventh Framework call.

assistant: **Objectives**

The project ULIXES aims to unravel, categorize, catalogue, exploit and manage the microbial diversity available in the Mediterranean Sea for addressing bioremediation of polluted marine sites. The idea behind ULIXES is that the multitude of diverse environmental niches of the Mediterranean Sea contains a huge range of microorganisms and their components (e.g. catabolic enzymes) or products (e.g. biosurfactant) that can be exploited in pollutant- and site-tailored bioremediation approaches. ULIXES intends to provide the proof of concept that it is possible to establish and exploit for bioremediation site-specific collections of microbial strains, mixed microbial cultures, enzymes, biosurfactants and other microbial products. These biotechnological resources will be mined by using approaches based on isolation of culturable microorganisms as well as by extensively applying advanced novel ‘meta-omics’ technologies recently developed by the project partners and exclusively available for ULIXES. Three pollutant classes recognized worldwide as environmental priorities will be considered: petroleum hydrocarbons, chlorinated compounds and heavy metals. A large set of polluted environmental matrices from sites located all over the Mediterranean Sea will be explored, including seashore sands, lagoon sediments, deep sea sediments polluted by heavy oil hydrocarbons at oil tanker shipwreck sites, hypersaline waters and sediments from polluted salty coastal lakes and natural deep hypersaline anoxic submarine basins and mud volcanoes where hydrocarbon seepages occur. The mined collections of microbial biotechnological products will be exploited for development of novel improved bioremediation processes whose effectiveness will be proved by ex situ and in situ field bioremediation tria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Highly advanced modular integration of insulation, energising and storage systems for non-residential buildings' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

POWERSKIN+ will develop and scale-up eco-innovative, cost-effective and smart material solutions to renovate existing facade systems of both double skin and advanced integrated curtain walls. It will smart integrate unprecedented highly innovative insulations and renewable energy technologies, with breakthrough features based on nano-formulated VIP, PCM, flexible thin glass perovskite solar cells and multi-functional nano-enabled coatings. Comprehensive POWERSKIN+ portfolio comprising off-site prefabricated modular “ready-to-buy” and ‘easy-to-install’ glazing and opaque elements, sustainable eco-designed connecting framings and a dedicated large capacity electric building storage system will be processed up to the final commercializable end products. Powerskin+ system will be validated in non-residential buildings in three different environmental, economic, logistic and social scenarios, namely Portugal, Slovenia and Czech Republic, with environmental sustainability and benefits proving through LCA and LCCA approaches. The market uptake of POWERSKIN+ will be facilitated by optimal compatibility without additional structural modification. It will benefit from: lightweight transparent (TM) and opaque modules (OM) (< 30 Kg/m2 and 5Kg/m2 respectively); improved insulation (TM GIU Ug-value 35% better than standard double glazing and OM VIP thermal resistance value 33% better than a 25mW/mK PIR); and on-site energy generation and storage elements (Perovskite-PV power conversion efficiency >12% and >8% for OM and TM respectively; 15% improvement in energy storage capacity), aiming to be recognized as an affordable high standard retrofit solution (installation cost and time reduce 50% and 74% respectively).


**Keywords:** Non residential,  buildings,  façades,  envelope,  rene
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Imperial Queers, Republican Subjects: The Politics of Queer Historiography in Turkey' (IQRS) targeting Horizon 2020.

assistant: **Abstract**

Historiography has played a crucial role in nation-building projects across the world and Turkey presents a striking exampleof this phenomenon. In the country’s formative years (1923-1938), while the government took measures to create an officialformulation of Ottoman and Turkish history, dissident groups across the political spectrum produced its alternatives. In bothhegemonic and alternative historiography projects, gender and sexuality were of key significance. This research analyzesthe politics of queer historiography and archival practice in this period by focusing on the works of three intellectuals:Hüseyin Rahmi Gürpınar (1864-1944), Reşad Ekrem Koçu (1905-1975), and Rıza Nur (1879-1942). The project examineshow these prominent queer figures, who were born in the Ottoman Empire and witnessed the emergence of the nation-state,produced alternative and queer formulations of the past in the service of Marxist, neo-Imperialist, and fascist ideologies asthey negotiated the politics of citizenship and belonging. To understand these processes, the project uses multi-sitedarchival research, and presents critical biographies of the authors together with close readings of the texts and performancesthey created. As the first comprehensive study on queer historiography and archival practice in Turkey, this research brings anew perspective to the sexual dimensions of nation-building. With the aid of ethnography, the project also analyzes thecurrent efforts to redefine the official formulation of Turkey’s history, and how the works of queer intellectuals continue toinfluence both mainstream and alternative historiographical projects in the country. The project thus challenges some of thepopular trends in Ottoman and Turkish historiography, especially the gendered and sexualized
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fourth Framework proposal for the project 'Film Actuators and Active Noise Control for Comfort in Transportation Systems'.

assistant: **Objectives**

Objectives and content Quality and comfort of transportation means are - to a considerable extent - assessed by cabin noise to which passengers are exposed. The disturbing primary noise sources are the combustion engine (cars, ships), wheel-surface interaction (trains, cars) and inter-cabin noise (ships). For airborne noise the transmission loss increases with the mass of the panels. The use of light-weight panels is on the other hand very important: manufacturing costs, fuel consumption and cargo capacity depend on the weight of the vehicle. The need for comfort obstructs the need for light-weight panels. The main industrial objective of the research is to demonstrate a major breakthrough in the development of active noise control systems, which can on the other hand increase the comfort and reduce the weight in transportation systems. This can be achieved by using high efficient flat film actuators as anti-noise sources. The new technical innovation, electro-mechanically treated film (EMF) can be used as an acoustic source. The actuators made of EMF are very thin, weigh very little, are mass-producible and thus cheap and can be placed on all desired places along panels. In existing cabins noise reduction using ANC can be more efficient and extended to higher frequencies. In future transportation systems light-weight panels on which the film is fixed can have acoustic transmission loss as high as the transmission loss of existing high-weight panels. The easy integration of low-cost EMF-actuators in ANC system can make the ANC systems extremely feasible in the control of low frequency noise. The main drawback with older ANC systems have been that they have not been compatible with mass-production and the price of the systems have been high. The technical objectives of t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Liver Investigation: Testing Marker Utility in Steatohepatitis' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Strongly associated with the epidemics of obesity and type 2 diabetes that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease that is characterized by substantial inter-patient variability in severity and rate of progression. It is currently assessed by liver biopsy, an invasive, costly and risky procedure. The lack of noninvasive biomarkers has hampered patient care and impeded drug development by complicating conduct of clinical trials.The overarching aim of LITMUS is to develop, robustly validate and advance towards regulatory qualification biomarkers that diagnose, risk stratify and/or monitor NAFLD/NASH progression and fibrosis stage. This will be achieved through a goal-oriented, tri-partite collaboration delivering a definitive and impartial evaluation platform for biomarkers, bringing together: (i) End-users of biomarker technologies (clinicians with expertise in NAFLD and the pharmaceutical industry)? (ii) Independent academics with expertise in the evaluation of medical test/biomarker performance? and (iii) Biomarker researchers and developers (academic or commercial).LITMUS has the demonstrable capability to fulfil the IMI call remit. Built upon foundations laid by the EU-funded FLIP/EPoS projects and long-established, successful scientific collaborations amongst many of Europe’s leading clinical-academic centres, LITMUS is at a unique advantage due to its existing large-scale patient cohorts, bioresources and multi-omics datasets. Consortium members are internationally recognised experts with substantial relevant expertise supporting the program’s clear focus on biomarker identification, validation and accelerating EMA/FDA qualification. Thus, LITMUS is powered to prov
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'Real uniruled manifolds'.

assistant: **Innovation**

The following list of questions describe the four main directions which I want to develop.1) Topology of real uniruled manifolds.May the connected sum of two closed hyperbolic manifolds of dimension at least three be Lagrangian embedded in a uniruled symplectic manifold? Being able to answer to this question through the negative using the symplectic field theory introduced by Eliashberg-Givental and Hofer requires to understand pseudo-holomorphic curves in the cotangent bundle of such a connected sum. For this purpose, one needs some understanding of closed geodesics on such manifolds. Conversely, what are the simplest real three-dimensional projective manifolds which have hyperbolic or SOL manifolds in their real loci?2) Enumerative problems in real uniruled manifolds.Is it possible to extract integer valued invariants from the count of real rational curves of given degree in the projective three-space (for instance) which interpolate an adequate number of real lines? Same question in dimensions greater than three for curves passing through points.3) Lagrangian strings in symplectic manifolds.I would like to investigate the interactions between closed Lagrangian strings and open Lagrangian strings in symplectic manifolds. These strings -which I recently introduced- interact through holomorphic disks both punctured on their boundaries and interiors. What can be the analogous TQFT associated to coherent sheaves on complex projective manifolds? How are these strings related to Gromov-Witten invariants?4) Volume of linear systems of real divisors.The theory of closed positive currents provides probabilistic informations on the topology of real hypersurfaces in Kähler manifolds. I want to push a work in progress as far as possible in this subject.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Advanced biomarker discovery for earlier diagnosis and improved prognosis of NAFLD stages via high resolution mass spectrometry.' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of nearly 25% i.e., affects one quarter of the adult population. Early phase NAFLD is reversible and can be treated, but it may progress towards life-threatening stages such as non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). The conventional diagnosis of NAFLD stages requires liver biopsy and is time-consuming and costly and there is an urgent need to identify biomarkers that can be applied in routine clinical settings, such as through blood-based testing. The identification of blood biomarkers would support earlier diagnosis and improved assessment of prognosis, ultimately supporting preventive/intervention measures to avoid progression to late stage liver disease and thus saving lives. In RENAISSANCE, a state-of-the-art liquid chromatography-high resolution mass spectrometry (LC-HRMS) metabolomics screening will be conducted upon the blood and blood-derived exosomes of a unique deeply phenotyped cohort of NAFLD patients for molecular biomarker discovery. Notably, exosome analysis shows promise for the identification of novel disease signatures but has yet to be applied to characterize NAFLD, providing high potential for the identification of new diagnostic/prognostic biomarkers for NAFLD. Furthermore, the LC-HRMS screen will be supported via targeted assays of redox metabolites and protein markers of acute inflammation. The integration of non-target and target data will provide insight into the underlying mechanisms of disease progression and further knowledge about potential causative factors of NAFLD.


**Keywords:** NAFLD, metabolomics, biomarker discovery, liver diseases, NASH
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Relationship between confirmation of Prp infectivity and pathogenicity of bovine spongiform and cephalopathy (BSE) as a bases for diagnosis' in the context of a Fourth Framework call.

assistant: **Objectives**

Transmissible spongiform encephalopathies (TSE) or prion diseases are a group of neurodegenerative afflictions which include Creutzfeldt-Jacob disease (CJD) in humans, scrapie in sheep and goats, and bovine spongi form encephalopathie (BSE) in cattle. In contrast to the many strains and PrP polymorphisms found in sheep, only one strain and one PrP polymorphism has so far been detected in cattle. In addition, BSE prions seem to be transmissible to humans orally, causing new variant CJD. So it is the important to monitor the frequency of prion disease in cattle since they are slaughtered for human consumption. Up to now, no reliable, specific test has been available for detecting prion disease in living animals.The main objectives of this European group with partners from France, Germany and the UK are the determination of the molecular properties conformation and conformational transitions of normal prion protein PrPc, the BSE version PrPBSE and PrP-peptides of the bovine sequence. They will be compared with the corresponding properties known for scrapie and CJD to differentiate between general principles and BSE-specific features.The partners will study the relationship between BSE infection, PrP-accumulation, PrP conformation, interacting ligands and the appearance of early markers, and thereby develop an optimal concept for a sensitive diagnosis.  A cell-culture system susceptible to BSE infection will be established. Specified antibodies and other PrP-interacting ligands such as RNA-aptamers will be studied systematically to differentiate between the normal and the disease-specific abnormal isoform of PrP. Until now a series of polyclonal anti-PrPBSE-peptide antibodies have been produced; furthermore RNA aptamerswere selected against PrPc and PrPsc. A specific and di