RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Multicompartmental Designs For Protocells' (Protoeukaryotes).

assistant: **Innovation**

Protocells are artificial mimics of cellular systems exhibiting some of the quintessential characteristics of living systems such as compartmentalization, replication and selective exchange of chemical species with the environment. Apart from enabling better understanding about the origin of life, protocells can also be perceived as micromachines which can be programmed to perform functions such as clinical diagnosis, drug delivery, remote sensing, environment detoxification, etc. The range of applications for protocells can be broadened by increasing their structural complexity which would enable complex functions. However, to date the structural complexity of protocellular models has been minimal. Eukaryotic cells are model systems for complexity with compartmentalization into membrane bound organelles interacting through selective exchange of metabolites resulting in complex chemical networks which make possible smart functions such as feedback regulation and homeostasis.  No parallel of this hierarchical organization exists in protocell literature. The aim of this proposal is to address this issue by design and construction of multicompartmental protocell models capable of complex functions such as self-regulation, locomotion and light harvesting. The interaction between the various compartments will be enabled by constructing gates across their membranes using stimuli responsive polymers to allow compartments to activate pathways which can affect the function or metabolite level of another compartment, leading to self-regulation of function or metabolite levels in the protocell. It is in this regard that the previous expertise of the applicant (Dr. Pavan Kumar) in constructing gates to control the transport in nanochannels will be applied to the multi-disciplinary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'A miniature Bio-photonics Companion Diagnostics platform for reliable cancer diagnosis and treatment monitoring.'.

assistant: **Objectives**

Current diagnostic options for cancer treatment monitoring rely on imaging techniques and cannot guarantee proper assessment of therapeutic response. This project aims to develop a disruptive Point of Care (PoC) device for cancer early diagnosis and treatment monitoring as a companion diagnostics tool. One of the scientific breakthroughs of this project is the development of a “cancer stem cells” detection platform by virtue of expression of the cancer stem cell-specific transcription factor TWIST1, which controls the expression of the bloodstream circulating biomarkers POSTN, PCOLCE and TGBI. Cancer stem cells represent the most aggressive/tumorigenic cell compartment within tumors. BIOCDx will combine advanced concepts from the photonic, nano-biochemical, micro-fluidic and reader/packaging platforms aiming to overcome limitations related to detection reliability, sensitivity, specificity, compactness and cost issues. BIOCDx will rely on ultrasensitive, photonic elements based on an array of 8 asymmetric MZI waveguides fabricated by TriPlex technology on silicon nitride substrates and will achieve a 100 fold improvement –with respect to current technologies- of sensitivity (<10-8 RIU). BIOCDx will emlploy a smart concept of signal multiplexing for lowering the number of photodetectors required in multi-analyte detection and allowing for a substantial reduction of chip size. A sandwich assay, enhanced with nanoparticles, will be developed, based on the use of two antibodies per protein, to detect all three circulating proteins. This will enhance the limit of detection (LOD) close to femtomolar and the reliability. BIOCDx photonic, nano-biochemical, fluidics and packaging platforms will be integrated into a portable, desktop PoC device. Its validation in preclinical and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Core LOSS during a severe accident' in the context of a Fifth Framework call.

assistant: **Objectives**

R&D work for 1300-PWR, BWR, VVER on risk-relevant core degradation issues is proposed with experiments at different scales up to integral tests.Selected topics with large databases uncertainties are:a)impact of high burn-up on UO2 and MOX dissolutionb)identification of fuel or collapse conditionsc)oxidation of B4C by steam and B4C control rod degradation / oxidation with related gas generated (H2, CH4,..) U-o-Zr oxidation kinetics.Topics b) and c) include different plant design components. The lack of exp. data means also non-validated or missing models in SA codes in spite of safety consequences e.g. H2 rate or production of CH4 with favour organic Iodine formation. Models developed will be implemented in SA codes. Expected results: 1/H2 and B4C decomposition gas release during core collapse, 2/ B4C/burn-up/collapse models included in SA codes, 3/ >Feedback on safety and consequences on AMMs for various plant designs.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Fast-Tracking Pathology via Automated Image Analysis and High-Performance Computing: Application to Prostate Cancer Diagnostics' under Seventh Framework.

assistant: **Concept**

Histopathology has traditionally been a low-throughput, labour-intensive technique. Conventional manual annotation of tissue slides requires a pathologist to examine the tissue and cellular components to grade the level of disease progression. However, digital pathology and automated digital image analysis solutions can provide a more rapid solution. In recent years, there has been a rapid uptake of digital pathology in both the academic and industrial sectors, each creating large image libraries with related manual and automated annotations, all stored on local systems. There is now a requirement to streamline this process and to provide a comprehensive set of tools for data integration and mining of this valuable, but often not fully exploited, information. There is also a need for inter-lab standardisation and the development of high-performance computing approaches to enable integration of multiple libraries and knowledge discovery. The FAST-PATH project will address these key issues to maximise the capabilities of the digital pathology workflow. Specifically, FAST-PATH will develop a set of tools, available through a web-based interface, to address the standardisation, integration and knowledge discovery of high-throughput digital pathology libraries and related manual annotations. We will focus on integration of oncology-based data generated from the academic and industrial partners involved, with a particular emphasis on prostate cancer. This inter-sectoral study will also involve validation of novel prognostic biomarkers via automated analysis of immunohistochemical images. Importantly, FAST-PATH will bring together 4 major European academic institutes and 2 SME partners with the central aim of streamlining digital pathology via the development of data standardi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'EuroGEO Showcases: Applications Powered by Europe' (2014-2020) targeting Horizon 2020.

assistant: **Abstract**

The E-SHAPE proposal is driven by the need to develop operational EO services with and for the users and to create a conducive environment whereby the strengths of Europe are exploited towards addressing societal challenges, fostering entrepreneurship and supporting sustainable development. The proposal objectives are 1) to develop operational EO services with and for users active in key societal sectors; 2) to demonstrate the benefits of the EO pilots through the coordinated downstream exploitation of EO data and the utilization of existing EO resources; 3) to promote the uptake of pilots at national and international scale, across vertical markets (private and public) and amongst key user communities; 4) to enable the long-term sustainability of the numerous pilots, their penetration in public and private markets and support their upscaling; 5) to increase uptake by raising awareness on the solutions developed through tailored and well-targeted communication, dissemination and outreach activities. The proposal aims at setting-up and promoting a sustainable organization dedicated to users’ uptake of European EO resources, building on Copernicus and GEOSS through the development of co-design pilots (i.e. application-oriented products, services or solutions) built on a user-centric approach and delivering economic, social and policy value to European citizens. It has also the ambition through the development of 27 pilots organized in 7 showcases to deliver information that will also contribute to the three GEO engagements (SDGs, Paris Agreement and Sendai Framework).


**Keywords:** Group on Earth Observation, GEOSS, Earth Observation, user’s uptake, co-design, showcasing, interoperability, INSPIRE, downstream services, users’ engagement, application-oriented initiative
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Transcriptional and epigenetic control of innate-like T lymphocyte development' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Invariant Natural Killer T (iNKT) cells are a heterogeneous T lymphocyte population that possess innate-like characteristics and contribute to host defense against pathogens. Due to their powerful effector properties, iNKT cells are targeted for immunotherapeutic and vaccination strategies. Their effector programs are acquired during thymic development, prior to microbial exposure, and are polarized into three distinct populations, similar to CD4 Th1, Th2 and Th17 lineages. Specification and subsequent polarization of the NKT lineage is regulated by the balance between the E protein family of transcription factors (TF) and their inhibitors, the ID proteins, which is pivotal in the bifurcation of adaptive and innate lymphoid lineages and is associated with human lymphomas. This application aims at defining the mechanisms by which the E/ID ratio enables the effector properties of innate-like T cells. We hypothesize that the E/ID pathway directly or indirectly regulates critical TFs and chromatin regulators that separately or in combination activate different arms of this effector program. This hypothesis will be tested through the following specific aims: 1) Determine target genes bound by E proteins,2) Determine the epigenetic chromatin states and3) Determine the role of chromatin modifiersin developing iNKT cells. While each aim can be accomplished independently, the data will be integrated to form gene regulatory networks that control the innate-like effector programs. The proposal is innovative because it explores the novel idea that the activity thresholds of a single TF dictate distinct cellular fates, while enhancing our understanding on lymphocyte effector programs and link specific chromatin regulators to these programs. The fellowship is rewarding, because the A
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'A HOLISTIC APPROACH OF ELECTRIC MOTOR COOLING'.

assistant: **Innovation**

Electric motors (e-motors) consume more than 40% of electricity produced globally. The EU aims to save ~40Mt of CO2 emissions per year until 2030 by deploying more efficiency e-motors. E-motors are also the driving force behind EVs, currently leading the global efforts for decarbonisation of the transportation sector; their efficiency is crucial in extending EV mileage. Unfortunately, electrification plans for heavy-duty, earth-moving machines and aircrafts (accounting currently ~60% of fossil fuel consumption in transportation) have to overcome, among other limitations, the technological barrier of excess heat generated in the e-motor copper windings during power-demanding operations associated with these sectors. E-COOL promises to address this challenge via the development of a holistic e-motor cooling technology, maximising heat transfer through direct-contact, spray cooling. E-COOL aims to achieve this technological breakthrough at time-scales compatible to those required for industrial innovation to reach the market, by integrating two interdisciplinary activities: (a) development and manufacturing of novel oil-based, dilute polymer mixtures of non-Newtonian nature, which, when employed in spray-cooling thermal management systems, will be a game-changer; (b) implementation of a universal design methodology for spray cooling, optimised with the aid of new Machine Learning (ML) algorithms. Training datasets for the ML tool will be obtained by ‘ground-truth’ experimental and numerical investigations also to be conducted for the first time in E-COOL. The envisioned cooling system aims to provide unprecedented cooling rates at local temperature hot spots, which can contribute to an average 20% increase in e-motor’s efficiency compared to today’s state-of-the-art. This
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'FoResight and Modelling for European HEalth Policy and Regulation' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

FRESHER brings together ten research groups, including leaders in the management of large European Foresight projects and highly experienced health policy modelers, in an interdisciplinary team engaged in FoResight and Modelling for European Health policy and Regulation. The overall project objective is the representation of alternative futures where the detection of emerging health scenarios will be used to test future policies to effectively tackle the burden of non communicable diseases (NCDs).  The project will produce quantitative estimates of the future global burden of NCDs in the EU and its impact on health care expenditures and delivery, population well-being, health and socio-economic inequalities, and potential changes in these impacts according to alternative health and non-health policy options. The added value of FRESHER lies in the fact that these estimates:- will not only be based on extrapolation of past health trends but also on foresight techniques (mapping of risk factors, horizon scanning and identification of key drivers for change, scenarios building) giving credit to the interdependencies of structural long-term trends in demography, gender relations, technological, economic, environmental, and societal factors at 2050.- will be produced through the development of an empirically-based micro-simulation model (starting from the Chronic Disease Policy Model of OECD), allowing to quantify the current and future health and economic impacts of NCDs and testing “what if” policy options according to alternative foresight scenarios, as well as potential new policies and policy combinations.FRESHER heavily relies on an interactive process with key stakeholders, at all stages of the project, in elaborating the framework, and giving inputs for the qualitativ
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Mesoscopic understanding of supported catalysts with overlapping electric double layers' (MESO-CAT).

assistant: **Innovation**

A defossilized global energy ecosystem hinges on efficient conversion between renewable electrical energy and chemical energy stored in molecules. This conversion requires precious catalysts to drive relevant reactions at practical rates. Many catalysts are employed in the form of nanoparticles (NP) dispersed on support materials. All relevant reactions occur in a nanoscale region at the interface between the solid catalyst and an electrolyte solution, i.e., an electric double layer (EDL).Our current knowledge of EDL is essentially limited to planar electrodes with a single EDL, whereas supported NP catalysts (SNPC) exhibit radically different EDL characteristics, featuring overlap of individual EDLs around the NPs and the adjacent support material. This knowledge gap, concerning crucial local reaction conditions within the EDL, prevents effectively transferring knowledge obtained at planar electrodes to performance improvements of SNPC.MESO-CAT aims at launching the mesoscopic (1~100 nm) science of overlapping EDLs in SNPC and unravelling the influence of overlapping EDLs on structure-activity relationship of SNPC. MESO-CAT will address three foundational questions in electrocatalysis of SNPC using theoretical methods in an interaction loop with experimentalists. First, how are the overlapping EDLs formed under realistic conditions? This will be studied using a unique theoretical approach for mesoscale EDLs with both quantum mechanical electrons and classical electrolyte particles treated on equal footing. Second, how do overlapping EDLs influence elementary electron transfer kinetics? This will be unravelled using a model Hamiltonian for proton-coupled electron transfer considering various EDL effects. Third, how do overlapping EDLs influence the overall structure-act
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Virtual Biodiversity Research and Access Network for Taxonomy' (ViBRANT).

assistant: **Innovation**

Biodiversity science brings information science and technologies to bear on the data and information generated by the study of organisms, their genes, and their interactions. ViBRANT will help focus the collective output of biodiversity science, making it more transparent, accountable, and accessible. Mobilising these data will address global environmental challenges, contribute to sustainable development, and promote the conservation of biological diversity. Through a platform of web based informatics tools and services we have built a successful data-publishing framework (Scratchpads) that allows distributed groups of scientists to create their own virtual research communities supporting biodiversity science. The infrastructure is highly user-oriented, focusing on the needs of research networks through a flexible and scalable system architecture, offering adaptable user interfaces for the development of various services.  In just 28 months the Scratchpads have been adopted by over 120 communities in more than 60 countries, embracing over 1,500 users. ViBRANT will distribute the management, hardware infrastructure and software development of this system and connect with the broader landscape of biodiversity initiatives including PESI, Biodiversity Heritage Library (Europe), GBIF and EoL. The system will also inform the design of the LifeWatch Service Centre and is aligned with the ELIXIR and EMBRC objectives, all part of the ESFRI roadmap.  ViBRANT will extend the userbase, reaching out to new multidisciplinary communities including citizen scientists by offering an enhanced suite of services and functionality.