RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Towards Understanding the Impact of Climate Change on Eurasian Boreal Forests: a Novel Stable Isotope Approach' (ISOBOREAL) under Horizon 2020.

assistant: **Objectives**

The vast boreal forests play a critical role in the carbon cycle. As a consequence of increasing temperature and atmospheric CO2, forest growth and subsequently carbon sequestration may be strongly affected. It is thus crucial to understand and predict the consequences of climate change on these ecosystems. Stable isotope analysis of tree rings represents a versatile archive where the effects of environmental changes are recorded. The main goal of the project is to obtain a better understanding of δ13C and δ18O in tree rings that can be used to infer the response of forests to climate change. The goal is achieved by a detailed analysis of the incorporation and fractionation of isotopes in trees using four novel methods: (1) We will measure compound-specific δ13C and δ18O of leaf sugars and (2) combine these with intra-annual δ13C and δ18O analysis of tree rings. The approaches are enabled by methodological developments made by me and ISOBOREAL collaborators (Rinne et al. 2012, Lehmann et al. 2016, Loader et al. in prep.). Our aim is to determine δ13C and δ18O dynamics of individual sugars in response to climatic and physiological factors, and to define how these signals are altered before being stored in tree rings. The improved mechanistic understanding will be applied on tree ring isotope chronologies to infer the response of the studied forests to climate change. (3) The fact that δ18O in tree rings is a mixture of source and leaf water signals is a major problem for its application on climate studies. To solve this we aim to separate the two signals using position-specific δ18O analysis on tree ring cellulose for the first time, which we will achieve by developing novel methods. (4) We will for the first time link the climate signal both in leaf sugars and annual ri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Fifth Framework proposal on 'Development of a european advanced level course in breast disease management for surgeons (EURALB)'.

assistant: **Concept**

Currently in Europe, there is a shortage of specialist breast surgeons, a shortage that becomes critical as Europe moves to specialise in key medical areas. EURALB aims to overcome this shortage and address training need deficits across Europe by adapting the British Association of Surgical Oncologists (BASO) course 'Advanced Management of Breast Disease', held annually at the Royal College of Surgeons, London and hosting it in countries across Europe to ensure that surgeons in all countries may access the course. A consortium of leading surgical societies, training organisations and teaching hospitals has combined to host two 'pilot courses' in Greece and Austria to create a model for the adaptation and hosting of the course to meet specific training needs in defined catchments areas. This model may then be used to launch Europe wide training.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Untranslated regions of RNAs and protein networks in pathological phase separation: UNDERPIN', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Aggregation of RNA binding proteins (RBPs) is a pathological hallmark of neurodegenerative pathologies such as Amyotrophic Lateral Sclerosis. The mechanism leading to RBP aggregation relies on the ability of these proteins to transition into membrane-less compartments such as the stress granules (SG) whose formation is normally regulated in physiological conditions. Yet, as RBPs are intrinsically prone to coalesce in large assemblies, their accumulation, when unregulated, can lead to cell toxicity. While the effects of amino acid mutations on RBP aggregation have been extensively investigated, a large amount of evidence indicates that nucleotide variants in untranslated regions (UTRs) can strongly impact RBP expression by altering the interactions with specific regulatory proteins.  UTRs provide a platform where multiple RBPs bind to orchestrate post-transcriptional regulation. I envision that UTRs, by directing contacting specific protein networks are crucial in aggregate formation and that alteration of their interactomesdue to disease-linked mutationscould impact the propensity to form SG and other assemblies. The main objective of UNDERPIN is to reveal interactions in regulatory regions of RBPs and to understand their effects on phase separation in physiology and pathology. Firstly, I plan to investigate the effects of disease-linked mutations on UTRs of RNAs encoding RBPs  by large-scale predictions of UTR-RBP interactors. Secondly, interactions between RBP and selected UTRs, with and without disease-linked mutations, will be revealed in human cells by RNA-protein interaction detection experimental method RaPID. Finally, the biological implications of UTR-mediated recruitment of RBPs will be deciphered providing molecular details on how UTRs and RBPs promote the fo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Resolving the mechanism of plant cell expansion at high spatio-temporal resolution.' (STORMtheWALL), addressing dissemination and exploitation.

assistant: **Impact**

Plants critically shape ecosystems and our societies by converting sunlight and CO2 into O2 and bio-mass while they grow. Understanding this growth process constitutes a major frontier in plant research. Growth is a multi-scale process. At a subcellular scale, it depends on the expansion of the cell walls, which involves changes in the chemistry and architecture of constituent polymer networks. Very little is known on the nature and the control of the cell wall changes that are critical for growth, in striking contrast to the, often detailed, knowledge of growth-regulating signaling networks. This is in part due to the lack of appropriate tools to study changes in the complex cell wall polymer assemblies that often occur at fast (~s) and small (<micrometer) scales. In this project, I propose firstly, to breach the spatial limits of the tools by using multi-target optical nanoscopy to visualize cell wall architecture and remodeling, and secondly, to overcome their temporal limits by using light-gated actuators and multiplexed intracellular biosensors to simultaneously perturb and monitor the system dynamics in vivo. In particular, I will address pectin remodeling, the role of which in plant growth was shown to be critical, but without clearly understanding the mechanism. My objectives are to (1) reveal the key changes in cell wall architecture and chemistry during growth, (2) understand the fast signaling by which cells perceive and coordinate wall remodeling, and (3) build a dynamic hybrid model to explain how plants coordinate wall expansion. This interdisciplinary project will provide new insights into the nanoscale organization of cell walls and propose a novel pectin-based mechanism for its active reorganization during growth. This will provide an essential framewor
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'New possibilities for accessing the capital markets for small and medium-sized biotech enterprises' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Because of the necessary high R&D investments and the costly market introduction and diffusion of biotechnology products (especially in the health care sector), small and medium-sized enterprises (SMEs) in the biotechnology area face specific problems in financing their business activities. In most Member States of the EU investments by venture capital companies in biotechnology are rather limited. As one reason for this fact investment managers primarily note the missing of a specific segment on the European stock market where shares of technology based SMEs are quoted. For this reason venture capital and other investment companies have some difficulties to find an adequate exit possibility if they intend to sell their investments in biotech companies via the stock exchange. Since a few years several stock exchange markets in Europe lower the requirements for the listing of small and medium technology-based companies. In this context the London stock exchange has taken the leadership by amending the rules for entry to the official list in 1993 and the opening of the Alternative Investment Market (AIM) in 1995. In addition, Le Nouveau Marché" opened for business on the stock exchange in Paris in February 1996. On the stock exchange in Frankfurt/Main a so-called "Neuer Markt" is planned for 1997 in which start-up or R&D intensive high-tech companies shall achieve a listing. In addition, a European pendant to the US NASDAQ located in Brussels was scheduled to open at the end of 1996 (EASDAQ). Therefore, a study is proposed which will systematically collect, analyse and critically evaluate the experience of biotechnology SMEs and investment companies which have already tried to go public on one of the above mentioned markets. In addition, it will be analysed under which ci
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Implementation of the Liquid infusion in theManufacturing of Aerospace Structures' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Liquid infusion process has been proved by recent researches to be suitable for the manufacturing of structural aeronautical components. The aim of this proposal is to develop a detailed analysis of the technical, economical and environmental impact of the extrapolation to industrial condition of the liquid infusion manufacturing technique. This analysis is deemed to be a necessary step in the successful scaling-up of the process for the fabrication of aeronautical components.The activity planned to achieve the aim of the proposal is organised in several work packages oriented to:- clarify the applicability of the process in the real industrial environment- identify the requirements to implement the process and to start the production phase- quantify the technical and economical impact of the new process- prepare a risk assessment and a manufacturing plan- define the optimum process procedures and an operative manualThe research team if formed by two universities and a private research center, all with a large experience in the field of composite and the analysis proposed will be carried out by using the state-of-the art techniques in the different areas, taking advantage of the synergistic competences of the partners in the key areas of the proposal (aeronautic composites manufacturing processes, realization of feasibility studies of industrial plants and processes, analysis of the environmental impact of industrial processes) and the data/information provided by the Topic Manager Company.""
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Exploring On-Chip Structured Illumination Microscopy Using Complex Patterns of Nanoscale Organic Light-Emitting Diodes', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

The Abbe diffraction of visible light underlies the spatial resolution in conventional optical microscopy, limiting the smallest dimension of Airy disk to approximately 250 nm. The invention and evolution of super-resolution (SR) fluorescence microscopy in the past three decades has showcased the ability to break the diffraction limit. Among all SR microscopy technologies, the structured illumination microscopy (SIM) represents one of the most popular methods to enable live-cell SR imaging at high speeds. However, despite the great promise, there are a number of challenges for SIM. First, the standard SIM relies on the interference of two laser beams, so the attainable lateral resolution does not match other SR microscopy counterparts. Furthermore, the SIM microscopes tend to be bulky, expensive, and prone to misalignment. In this project, we propose to use the nanoscale organic light-emitting diodes (Nano-OLEDs) as an on-chip excitation source to illuminate samples with highly complex structured illumination patterns, termed NANOLED-SIM. The realization of NANOLED-SIM can unlock high-order Fourier components for the resolution of high-frequency information, with single shot of illumination. The molecular-beam holographic lithography (MBHL) developed in my group will be used to fabricate complex patterns of luminescent organic semiconductors, which will then be integrated in a top-emitting Nano-OLED device on silicon chips. We will experimentally examine the photoluminescence and electroluminescence radiation patterns of our Nano-OLEDs in both real and Fourier spaces to access to the low-frequency information. Lastly, we will test our fabricated Nano-OLED chips in fluorescence microscopy, followed by developing the deep-learning-assisted image deconvolution algorithms t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Centre for application of ion beams in materials research' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

Description:The aim of the research activities of the AIM is to contribute to the development of European materials research by using the widespread possibilities of ion beam techniques. Basic research is combined with the development of technological applications. Technical process development is accompanied by studies which improve the understanding of basic mechanisms.For this purpose, in-situ diagnostics play a prominent role and enhance the efficiency of technical developments:7 beam lines for ion beam analysis, (2x RBS, ERDA, external proton beam - PIXE, NRA, nuclear microprobe, high-resolution RBS with magnet spectrometer);3 ion implanters, (200 kV and 160 kV high current implanters, 500 kV implanter); 2 devices for plasma-based ion implantation, (200-liter chamber, metal PBII);2 devices for ion beam assisted deposition (IBAD);1 Fine-focused ion beam machine IMSA-100;1 Low-pressure plasma processing device presently with ICP plasma);Simultaneous Double Implantation Chamber, Target Station Combining: - 3MV Tandetron and 500 kV Implanter - Ion Beam Analysis ERDA at Nuclear Microprobe - Real-Time In-situ Analysis with ion beams.Application:Main results:Total access delivered: 871 shiftsTotal number of users: 61Project Manager:Wolfhard Müller, Institute of Ion Beam Physics and Materials Research, Dresden 01314, P.O. BOX 510119, GermanyTel: +49-351-2603348Fax: +49-351-2602703E-Mail: a.kolitsch@fz-rossendorf.de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Thermal phenotypes and behavioural syndromes as predictors of resilience to climate change in European freshwater fish' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Predicting, preventing and/ or ameliorating the consequences of climate change is a major strategic objective of the European Union, particularly regarding ecology and biodiversity. Many species compromised by warming have shifted their distributions to areas of higher latitude to track their ‘climate niche’. However, the ability of compromised species to track their climate niche is constrained if their habitats are closed environments, such as river catchments whose physical boundaries inhibit species’ movements between catchments. Many freshwater species can thus only respond to warming in-situ. In fishes, fine-tuning of body temperatures can be through ‘behavioural thermoregulation’, where individuals use microhabitats that provide their preferred thermal conditions, assisted by rivers providing highly heterogeneous thermal environments. There is, however, a substantial knowledge gap on how freshwater fish are altering their behaviour and habitat utilisation in rivers that are warming due to climate change, and how this confers resilience to populations from the damaging effects of temperature increases. Through strong reciprocal knowledge transfer, and high complementarity between all participants and the proposed research, the research quantifies the extent to which the behavioural thermoregulation of river fishes is governed by specific phenotypes within a pace-of-life-syndrome that provides vulnerable populations with inherent resilience to climate change. The Action delivers innovative and novel research by bringing together a highly talented researcher with substantial knowledge in freshwater fish ecology with a European research group with exceptional expertise in fish telemetry and behaviour, and microclimate ecology. The high complementarity of all particip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Subunit localization of the Drosophila 26S proteasome by means of 3D cryo electron microscopy', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

In eukaryotic cells, the majority of cytosolic and nuclear proteins are degraded via the ubiquitin–proteasome pathway. Proteins carrying multiubiquitin tags are selected and degraded by the 26S proteasome, which is a large molecular assembly built from 30 different subunits.Two major components form the 26S complex: the proteolytic core particle (CP) and the regulatory particles (RPs).Whereas the structure and enzymatic mechanism of the CP have been studied in great detail, current understanding of the structure and function of the RP is lagging behind, together with the correct structural analysis of the 26S proteasomes. As a consequence of the low structural stability of the complex, electron micrographs of 26S preparations display structural heterogeneity that complicates image analysis and three-dimensional reconstruction. In the research proposal presented here, extensive effort will be devoted for the elucidation of the subunit topology of the RP. For this purpose, subunits will be labelled with various techniques, and their position within the 26S proteasome will be mapped by means of single particle cryo-electron microscopy. By applying 3D cryo-electron microscopy, the localisation of the labelled subunits can be reliably interpreted in terms of topology.The research project also aims to identify the subunits involved in the formation of the binding surfaces between the base and lid subcomplexes of the RP and the identification of the subunits involved in linking them. In the third stage of the project we will focus on mapping the tetraubiquitin binding site of the 26S proteasome by comparing the structure of the tetraubiquitin-26S proteasome complexes with the structure of 26S proteasome without tetraubiquitin. These approaches will allow for the first time the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Design Customized Support for Innovative SMEs' to be submitted under Horizon 2020.

assistant: **Abstract**

The aim of this specific project is to set up a brand-new innovation support service –a service that will enable both the country make profit out of its investments on SMEs and the SMEs further develop their operations by enhancing the use of Design. Two closed groups will be developed; the first one will be a traditional group of 5 beneficiaries of previously implemented programmes, which will run the common procedure after finishing the implementation of their project –the Comparison Group. This group, just like all those beneficiaries till today, will have no contact/support by our organisation, after finishing their project. The second closed group will make use of the new innovation support scheme. A closed group of 5 SMEs –the “Treatment Group”– will be selected and they will be offered a Design Clinic service, a service that through which, they will fully understand their future challenges and which are their opportunities. They will be also offered some introductory workshops in order to understand the value of Design and its mindset.  After the introductory workshops, they will receive a Design Customized Mentoring service –a service through which they will be provided guidance on how to strategically integrate design thinking in their products, services and operations. This is a new innovation support scheme, which seems more than needed. A call for expression of interest will be published targeting to SMEs that have already made use of a financial support programme. After selecting the Treatment Group, the project will directly call SMEs that will be monitored regarding their business indicators, and will not receive the new service, formatting the Comparison Group. This way, the project will assure that the two groups will be equivalent. The project will mon