RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Retinal degeneration and control of cell polarity (CRUMBS THERAPEUTICS)' demonstrating excellence, impact and implementation quality for a Fifth Framework call.

assistant: **Abstract**

Mutations in the Crumbs homologue 1 or CRB1 gene lead to photoreceptor degeneration resulting in retentions pimentos type 12 (RP12), Leer congenital anacrusis (LCA) or classical autonomic recessive RP. The fruitfully Crib protein is essential for the polarisation of ectoderm ally-derived epithelial cells. CRB1 is expressed only in photoreceptors and brain and is expected to play a determining role in cell polarisation. Using fruitfully, human and mouse genetics we shall analyse the biochemical, cellular and physiological functions of CRB1, its family members and CRB1-interacting-proteins (Caps). We shall analyse the retinal degeneration in mouse models for RP12 and LCA. We will generate gene expression profiles using oligonucleotide microarray analysis to determine the cellular and molecular changes during the onset of the neurosensory disease. We expect to deliver lent viral gene therapy vectors to prevent the onset of RP12 and LCA.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Understanding Land Grabbing in Eastern Europe and Central Asia: an Integrated Assessment of Impacts, Conflicts and Trade-offs""' (EASTGRAB).

assistant: **Innovation**

The major aim of the EASTGRAB research project is to deepen the existing knowledge of the socio-economic and environmental aspects which characterize the process of agricultural land acquisitions due to commercial purposes, especially in marginalized and poor areas of the world. This process of land trade has been defined recently in the academic literature and in the media as “global land grabbing”. The convergence of global crises in food and energy, has driven a re-valuation of land resource. Transnational and national actors buy or lease large portion of land outside their country borders and all over the world to ensure food, energy and water security at home. The contemporary global land grab has recently become a key development issue. Due to the complexity of the topic, in terms of the large amount of aspects that have to be taken into account, as well as due to the novelty of the research field, in-depth analysis has become crucial in order to have deeper and meaningful debate around this issue. Further research is needed to collect information on land acquisition processes in countries where few studies have been (yet) undertaken, such as is the case of Eastern Europe, as well as Central Asia Region. The EASTGRAB project will further advance the scientific knowledge on this complex and emerging field of research from an interdisciplinary perspective in that region, and specifically in Ukraine, which due to the magnitude of foreign land acquisitions represents the most significant example of land grab in Eastern Europe. The research will integrate methods which belong to both social sciences, such as institutional and conflict analyses, and natural sciences, such as land use changes and environmental degradation due to natural resources’ exploitation. The resul
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Optimisation of Geothermal Drilling Operation with Machine Learning' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Geothermal drilling industry faces various challenges such as poor overall drilling confidence and performance, and lack of bottom hole awareness resulting in NPT, tripping time etc. OPTIDRILL concept was born to address and solve problems in drilling for geothermal resources that increases uncertainty and well construction costs. OPTIDRILL ´s innovative drilling advisory system is based on a combination of enhanced monitoring systems, multiple data-driven ML modules, each being responsible for either analysis, prediction, or optimization of one aspect of drilling or completion process.OPTIDRILL consortium, brings together highly experienced drillers, drilling project managers, engineers and operators, each having a different, yet complementary set of expertise in differing geological conditions, operating parameters and production end-goals. They will be providing data from various wells around the world.An enhanced monitoring system will be developed based on real time MWD systems as well as acoustic and vibration sensors. The automated machine learning analysis method will predict drilling parameters, using a real-time monitoring and optimization tool, as a unified system combining existing data and the newly developed methods, and finally, a coupled drilling optimization models to reduce overall geothermal drilling and production cost.The goal is to advise and support drilling operators in making informed decisions through real-time data, reducing many of uncertainties associated with drilling, which in term leads to less NPT, as the drilling can be more readily optimised to maintain good ROP, borehole control and address possible drilling issues, before they could impact operation. The OPTIDRILL Advisory System is NOT an attempt to just fully automate drill rig ope
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'ERAWATCH Monitoring and Analysis' in the context of a Seventh Framework call.

assistant: **Objectives**

ERAWATCH is a public web based platform that presents information and analysis on European, national and regional research policies, actors, organisations and support measures. The service currently covers the 27 Member States of the European Union, countries associated to the European Community's Research Framework Programme and, for comparative purposes, several non EU countries. ERAWATCH also produces analytical reports to investigate further research policy issues across Europe. ERAWATCH is primarily intended for a policy audience, in particular policy-makers and analysts in the area of R&D, at EU, national and regional level. It seeks to contribute to sound policy-making at all levels of governance by offering evidence and insights into the European R&D landscape.The work proposed represents an important evolution in the development of ERAWATCH, building on the experience of work to date, and the conclusions of a recent external expert evaluation. Moreover, the new impetus given to the realisation of the ERA through the ERA Green Paper, and its contribution to the renewed Lisbon Strategy, place greater importance and on the required role and impact of ERAWATCH. Following a trajectory of ongoing enhancement of the services it provides, ERAWATCH will continue to provide support for evidence based policy making for research policies at national and European level. It will continue to collect data and produce analytical products of recognised quality and relevance, in an appropriate and consistent format, and according to a timetable for suitable policy use. ERAWATCH will continue to strengthen its focus on ERA, mainly along the axes of the ERA Green Paper. However, this is balanced against the need to develop and maintain the broader capabilities to anticipate and add
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'HIgh throughPut LasER processing of DIamond and Silicon' (HIPERDIAS) targeting Horizon 2020.

assistant: **Abstract**

Driven by the end-users requirements and needs, the main objective of the HIPERDIAS project is to demonstrate highthroughput laser-based manufacturing using high-power, high-repetition rate sub-1ps laser. Although the laser system to bedeveloped within HIPERDIAS can address other material processing applications, the focus here will be 3D structuring ofsilicon at high-speed, precision processing of diamond material and fine cutting of metal for the watch and the medicalindustry. Chirped Pulse Amplification (CPA) approach based on highly efficient compressors gratings will be implemented inorder to minimize the overall losses of the laser system. The final targets of the project are to demonstrate:- a 10-times increase of ablation rate and productivity of large area 3D-structuring of silicon- a 10 times increase of speed in fine cutting metals- an increase of process speed (6-10 times) at a low processing tools cost of diamond machiningTherefore, the laser parameters, as well as the beam shaping, beam guiding (based on Kagomé fibers) and machinesystems will be developed and optimized to fulfill the above manufacturing targets. The laser architecture will be based onfully passive amplifier stages combining hybrid (fiber-bulk) amplifier and thin-disk multipass amplifiers to achieve sub-500fsat an average output power of 500W and sub-1ps at an average output of 1kW, at a repetition rate of 1-2 MHz. Furthermore,second harmonic generation (SHG, 515 nm) and third harmonic generation (THG, 343 nm) will be implemented to allowprocessing investigation at these wavelengths. At 515 nm (respectively 343 nm) an average power of >=250W (respectively>=100W) shall be demonstrated.


**Keywords:** Fiber beam delivery, ultrafast lasers, high-efficiency grating compressors
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Fibre Optic Networks for Distributed and Extendible Heterogeneous Radio Architectures'.

assistant: **Concept**

Current two big trends in wireless communications are the development of new broadband component and the integration of heterogeneous wireless networks, to achieve the vision f the so-called 4G network.<br/>The FUTON project addresses both issues by proposing the development of a hybrid fiber-radio infrastructure transparently connecting remote antenna units to a central unit where a joint processing can be performed. This allows the development of virtual MIMO concepts to achieve broadband wireless transmission, and also inter-cell interference cancellation. Furthermore the fact that several heterogeneous systems are co-localized enables the development of efficient Common Radio Resource Management procedures.<br/>The focus of the project includes two main components: one, the dominant, dealing with technical aspects and a second addressing business / deployment models related with the techniques under study.<br/>At the technical level the main goals are<br/>- Specify, design, implement and provide proof of concept for a hybrid optical-radio infrastructure enabling the integration of heterogeneous systems including the broadband component of future wireless systems <br/>- Exploit the potentialities offered by the transparent infrastructure to specify and develop the PHY and MAC layer of the broadband wireless system based on distributed processing.<br/>- Exploit the potentialities offered by the infrastructure for distribution of heterogeneous radio services and develop mechanisms for inter-system coordination and optimum usage of the radio resources and provide the proof of concept.<br/>And in terms of deployment/ business models<br/>- Evaluate the implications on the current wireless architecture models of the FUTON concept, determine cost models for upgradeability /
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'The role of host cell actin cytoskeleton in invasion by Apicomplexa parasites' (API-INVASION) targeting Seventh Framework.

assistant: **Abstract**

Members of the Apicomplexa phylum are obligatory intracellular parasites many of which being important human pathogens. Plasmodium sp., the etiological agent of malaria is the most devastating but Toxoplasma gondii can be severe in both immune-compromised individuals where it causes encephalitis or pneumonia and infect fetuses. These parasites invade host cells by transforming into specialized stages called zoites and most of our current knowledge on the few second-lasting entry process comes from studies using Toxoplasma tachyzoites and Plasmodium sporozoites. Upon contact between the two cells, the close apposition between membranes forms a unique type of cell-cell junction which accompanies parasite active propelling into the host cell. The current dogma stipulates that the zoite driving force critically depends on its actomyosin motor while the host cell remains essentially passive. However, new evidence from Tardieux’ laboratory recently contradicts this view. Live video and confocal microscopy indicate that de novo actin polymerization is important for entry of P. berghei sporozoites and T. gondii tachyzoites to promote anchoring of the zoite-cell junction on which the parasite pulls to penetrate the host cell. In this proposal, using both Plasmodium and Toxoplasma zoites, we aim at dissecting the molecular mechanisms that control actin assembly/disassembly in the host cell during entry. To this end, we plan to identify (i) the up-stream host cell signalling factors leading to the host response (ii) the parasite proteins released into the host cell which potentially contribute to this response (iii) assess the function of these parasite factors during invasion. To address these points, live confocal imaging of invasion will be combined with in vitro biochemical ac
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Multi-Agent Systems and Secured coupling of Telecom and EnErgy gRIds for Next Generation smartgrid services' to be submitted under Seventh Framework.

assistant: **Abstract**

The success of the European vision of a low carbon electricity grid that minimises greenhouse gas emissions; and enhances security, quality and reliability of supply depends on how smart infrastructures, combining energy and telecom, are developed and implemented for the wider integration of security-aware distributed energy resources into the increasingly decentralised grid. MAS2TERING, a 3-year technology-driven and business-focussed project, is aimed at developing innovative information and communication technology (ICT) platform for the monitoring and optimal management of low-voltage distribution grids by integrating last mile connectivity solutions with distributed optimisation technologies, while enhancing the security of increased bi-directional communications. The project also aims at enabling new collaboration opportunities between grid operators and telecom and energy companies, both from technology and business perspectives. The project consortium includes prominent industrial organisations and research institutes from the European energy, telecom and security fields, to leverage the critical dimensions of energy, ICT, security and business. Nine project partners are CEA, Utility Partnership Limited, R2M Solutions , ENGIE, Cassidian CyberSecurity, Telecom Italia, Cardiff University, Waterford Institute of Technology and Laborelec, from five European countries: France, United Kingdom, Italy, Ireland, Belgium.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Supplying lung adenocarcinoma cell lines to the cancer research community.' (SLACC) targeting Horizon 2020.

assistant: **Abstract**

This project aims to protect, and commercialize a new panel of transplantable mouse lung cancer cell lines with defined mutation status (MLC) for cancer research and drug discovery. In addition, we aim at disseminating and exploiting a novel method for generating an unlimited pool of such lines from various strains of mice. Human lung cancer is characterized by a variety of mutations in oncogenes (i.e., KRAS) and tumor suppresors (i.e., TRP53), which largely determine whether lung tumors respond to a given therapeutic regime. Human lung cancer cell lines are invaluable for in vitro studies, but need to be propagated in immunodeficient mice, compromising the validity of the results obtained. A panel of syngeneic MLC with a defined and a genetically malleable battery of mutated oncogenes would allow more physiologically relevant studies, would help accelerate research and drug discovery in the field, and would generate substantial interest in the academia and the industry. For the purposes of mother project FP7-IDEAS-ERC-StG-2010-KRASHIMPE-260524 aimed at studying KRAS-driven host-tumor interactions, we derived such MLC lines from the lungs of mice using exposure to tobacco carcinogens or genetic oncogenesis. We request funding to i) characterize MLC lines to show proof-of-concept data that they can be used for drug and oncogene discovery; ii) assemble them into a marketable product; iii) protect these discoveries; iv) assess their market potential; v) attract potential interested parties; and vi) commercialize this new product. We hope the results of this project will speed up investigation and drug discovery by shortening the presently wide time interval between cancer wet bench research and clinical applications.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Blood test for clinical therapy guidance of non-small cell lung cancer patients' (LungCARD).

assistant: **Concept**

Lung cancer is the most common cancer worldwide. NSCLC alone make up about 75% of all lung cancers and most hospitals currently test all NSCLC patients for EGFR mutations (pharmacogenomics) for treatment decision (personalised medicine) – i.e., patients with mutation(s) in EGFR gene should receive a EGFR-Tyrosine Kinase Inhibitor (TKI) drug (e.g. afitinib) treatment; while those that do not present mutations in such gene, should be treated with chemotherapy. Currently, the laboratories use PCR and Sanger sequencing technologies to perform the EGFR analysis from tumour biopsies - Fixed Paraffin Embedded (FFPE) samples. Still, some patients (e.g., 30% in UK) may never get histological confirmation because they are too sick to make a biopsy. Furthermore, the results obtained with current methods still present low quality, mainly due to poor quality/low yield of DNA extracted from FFPE samples. The FP7 LungCARD project (www.lungcard.eu) has developed and demonstrated a LungCARD system - an automatic system composed by microfluidic chip and chip analyser - that allows to capture circulating tumour cells (CTCs) from blood samples, amplify by multiplex PCR and detect EGFR mutations, including also a software for data analysis and report. Although this new blood test has proven to be faster, cost-effective and human error-free, the detection of somatic mutations in EGFR gene at frequencies lower than 20% is still a weak point. Therefore, the main project’s goal is to benefit from this technology, through the development, improvement, integration and validation of the LungCARD system with NGS workflow and development of a software for automatic reporting clinical results. However, LungCARD project aims to go further, by putting together a global and unique network of multidiscip
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Virus-Inspired modular Assembly for cargo loading in Extracellular Vesicles-Inspired CArdiac REpair' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

The fundamental objective of the VIA-EVICARE ERC Proof of Concept project is to ascertain the technical and commercial feasibility of a ground-breaking technology to revolutionize the delivery of therapeutics via extracellular vesicles (EVs). EVs are naturally occurring nanosized vesicles that facilitate the transfer of biological cargo between cells and offer numerous benefits over conventional drug delivery systems. By leveraging a novel, virus-inspired mechanism, we aim for a modular design that combines a significant improvement of targeting, loading, and release of therapeutics that overcomes the limitations of existing strategies. By designing and synthesizing self-assembling viral proteins and recruiting EV biogenesis components, we aim to:I.Validating the efficiency and specificity of EV-therapeutic loading, EV-generation, and EV uptake mechanisms upon introduction of different self-assembling proteins.II.Optimizing the modular design for large-scale production, ensuring reproducibility and cost-effectiveness and validate our innovative VIA-EVICARE loading strategy by assessing biodistribution and functional delivery in vivo.III.Conduct a comprehensive intellectual property (IP) landscape analysis to establish freedom-to-operate (FTO) and ensure that our technology can be commercialized without infringing on existing patents.IV.Develop a robust and detailed business plan to effectively guide the commercialization of our loading technology, thus bringing a transformative solution to treating various diseases.