RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'The influence of environmental factors on the participation and quality of life of 8-12 year old children with cerebral palsy in 6 eu countries (PARTICIP-CP)' (PARTICIP-CP).

assistant: **Concept**

Cerebral palsy is the commonest cause of physical impairment in childhood and associated with cognitive and sensory impairments. It occurs in 1 in 500 births, or 10,000 new cases a year in the EU.Average life expectancy is at least 40 years. Children with cerebral palsy continue to be seriously disadvantaged with respect to social relationships, education and employment prospects. A collaboration of 14 cerebral palsy registers, funded by the EU, has already registered 6500children and standardised the identification and assessment of children (including severity of impairment). In children with stable impairments (as compared to children with illness), the two key outcomes of Participation and Quality of Life are especially influenced by physical, social and attitudinal Environmental Factors (Eves) as well as medical interventions. Our principal hypothesis is that children with similar severity of impairment will experience variable outcomes in different countries due to variation in Eves. This will allow the identification of Eves, which, if improved, will yield the greatest benefits for children and their families. Such knowledge will inform EU policy in the health, educational and social sectors and generate protocols to optimise outcomes. It is a further hypothesis, testable in a subsequent study, that successful management of these Eves will have long-term ...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Addressing technical & human factors involved in the implementation of 3 point shoulder harnesses, on all seats, in passenger's aircraft' (GOING-SAFE) targeting Fifth Framework.

assistant: **Abstract**

Objectives: Implementing the results of DYNASAFE / IMT Programme. The objective of DYNASAFE was to demonstrate, by full scale dynamic testing, that the automobile concept of a 3 point shoulder harness is enhancing the passenger's tolerance to crash forces and is compatible with the structural limitations of current aircraft floors.The objective of GOING-SAFE is to take advantage of the automotive methodology and experience and to integrate them with the results of the Dynasafe Project, to provide in air transport an equivalent level of passive protection for all passengers, including the children from 0 to 7 years old. The resulting propositions to the Air transport Industry would be compatible with the passenger's comfort and the airline commercial and technical requirements.The Consortium in charge of DYNASAFE, aware of the policy expressed in the 3d. call*, is proposing to expose the newly defined state of the art to the passenger's criticism and the airline's appreciation.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'ShaMROCK – Secure professional Mobile Radio Over Commercial networKs' (ShaMROCK).

assistant: **Concept**

Of absolute critical importance to the overall security and the resilience of Urban areas, are the emergency services and the communication networks that they utilize. ShaMROCK will leverage the market position and Push To Talk(PTT) technologies of Genaker in order to deliver the World´s first broadband Professional Mobile Radio(PMR) system running over standard cellular networks. Such a system is just starting to be demanded by International Governments for usage by Emergency Services and Professionals to firstly, reduce costly dependency on dedicated networks, to secondly, increase communication resilience and network reliability and thirdly, to support a new generation of point-of-use urban infrastructure protection applications.Genaker is a European SME in a unique technological and market position to be able to develop an innovative solution to this market need. Genaker proposes to use the ShaMROCK project in order to fully validate its business case, canvas and plan using a ‘hands-on’ approach including a small-scale demonstration and interaction with all known stakeholders. ShaMROCK will form a key milestone in Genaker´s plans to execute this identified high-value business opportunity which has the clear capacity to greatly increase our sales, to capture further investment and to drive our rapid expansion.


**Keywords:** Market Demand User needs Emergency Service Mobile PTT Push-to-Talk-over-Cellular ESMC-PoC High Bandwith Secure Comms Mission Critical Group Voice Communication traffic over LTE
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identifying Variable Chromatin Modules using single-cell epigenomics' (CHROMISE).

assistant: **Innovation**

Most common disease-associated genetic variants are thought to fall into gene regulatory regions, where they affect the interaction between transcription factors (TFs) and DNA and induce transcriptional changes. To understand the extent of, and the mechanisms underlying variation in binding of TFs to DNA, genome-wide TF and chromatin state profiling studies were performed which revealed that non-coding variants frequently mediate coordinated changes in TF binding and chromatin mark enrichment over regions that span more than 100 kb. These regions were termed “variable chromatin modules” (VCMs), providing a conceptual framework of how regulatory variation might shape complex traits. However, little is known about the formation, function, or plasticity of VCMs. This is because vast amounts of epigenomics data have so far been required for identifying VCMs, making their identification costly, labour-intensive, and only applicable to easy-to-culture cell types. Recent work has demonstrated the value of ATAC-seq for defining regulatory element hierarchies that conceptually resemble VCMs. Here, I propose to extend these principles by developing an experimental and computational workflow for VCM identification using single-cell ATAC-seq. This will allow sample multiplexing for sequencing followed by genotype-based demultiplexing, thereby increasing throughput, minimizing sample input, and mitigating variation between samples (Aim 1). I will apply this workflow to study VCM plasticity during human mesenchymal stromal cell differentiation (Aim 2). The resulting data will be used to identify VCM-linked metabolic disease-relevant genetic variants, whose role in VCM formation will be validated using CRISPR-Cas9 (Aim 3).
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Development of a careful operating debridement device' under Fifth Framework.

assistant: **Concept**

Life expectancy in Europe increases steadily. This leads to an increase of age-specific diseases. To this category come among others diabetes and venous insufficiency. These ailments are a concomitant of difficult to cure wounds. Extensive wounds can be caused by diseases such as diabetes and venous insufficiency as well as by accidents e.g. burns, dirt tattoo etc. Goal of the proposed project is the development of a device to clean extensive wounds b using a mild water jet which can be used from cutting over to rinsing, washing or stimulating a wound. It will have an integrated shielding and exhauster system in order to avoid contaminating the environs. The complete unit must be compact designed and affordable to normal doctors in order to guarantee a most broad exploitation. So that as many sick people as possible can gain the envisaged advantage of the treatment.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Pulmonary drug delivery using low shear nebulization sprays' (SprayDelivery) under Horizon Europe.

assistant: **Objectives**

Respiratory diseases are one of the leading causes of death worldwide. The recent global pandemic of severe acute respiratory syndrome (SARS-CoV-2) has made us realize that effective and widely acceptable therapies against such diseases are still lacking and urgently needed. Administering drugs through aerosolization directly to the lungs, i.e. pulmonary delivery, enables targeted therapeutic effects while minimizing side effects by reducing systemic drug exposure. However, generically aerosol delivery is not very efficient, with only 5-15% of the initial medication deposited in the lungs. This is primarily linked with a wide aerosol drop size distribution, leading to inefficient aerosol deposition in the upper rather than lower respiratory tract. In addition, degradation of the medication during nebulization is also a challenge. This project aims to bridge the gap between aerosol generation and the deposition and transport of medication into the respiratory tract. We first propose an innovative soft nebulization method that reduces aerosol droplet coalescence by charging aerosols through friction. We will then use this optimized nebulization method to investigate how medication aerosols impact on the mucus in the respiratory tract, and devise strategies to enhance targeted aerosol deposition. In addition, we will investigate the transport of drug formulations within the airways in relation to their different rheological properties related to typical various respiratory diseases. This project will establish transformable and applicable technologies for advancing aerosol drug delivery to the respiratory tract.


**Keywords:** aerosols, spray, fluid dynamics, drug delivery, lipid nanoparticles, mucus, respiratory diseases
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Cellular innovation driving nervous system evolution' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

Nervous system evolution involved multiple cellular innovations, enabling fast synaptic transmission,novel sensory modalities, and complex forms of neural connectivity. These innovations weredistributed to an ever-increasing number of neural cell types, each specified and maintained by thecombinatorial activity of transcription factors. When, where, and how did this complexity arise?This proposal aims at resolving the history of cell type diversification that led to this complexity, fromthe birth of the first neurons to the many families of neuron types that exist today. Our emphasis willbe on reconstructing the cellular diversity in the ancestor of bilaterian animals and finding the keymolecular innovations that drove early nervous system complexity.Towards this aim, we will first use whole-body single-cell RNAseq, in combination with a spatialexpression atlas at cellular resolution, to comprehensively characterise cell types in the model annelidPlatynereis dumerilii, a genetically tractable, slow-evolving bilaterian. We will then generate andcompare similar datasets from diverse bilaterians and non-bilaterian outgroups to map the history ofneuronal cell type diversification and infer the key regulatory and functional innovations that gaverise to the first bilaterian nervous system. For several such regulatory innovations, we willexperimentally validate transcription factor binding to effector gene loci via superresolutionmicroscopy and chromatin immunoprecipitation. We will also investigate neuron family-specificprotein complexes, their subcellular localization, and neural functions via biochemical and proteomicsapproaches, correlative microscopy and loss-of-function analyses.This analysis of neuronal cell type diversity will for the first time trace the evolutionary
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Identification and characterisation of plant Golgi biosynthetic multiprotein systems' (GolgiBiosSys).

assistant: **Innovation**

The Golgi apparatus is a system of organised membrane structures that performs pivotal cell functions: biosynthesis and secretion of polysaccharides, protein and lipid glycosylation. The relevance of this organelle is measured by the amount of biomaterial produced by its activity. The highly abundant polysaccharides account for at least a third of all renewable organic carbon on Earth and are of great importance to the biosphere and to humanity, providing food, fibre and fuel. The functionality of the Golgi is thought to be governed by molecular organisational features, as the precise arrangement of its membrane proteins. Each of the numerous biosynthetic pathways performed in the Golgi requires the cooperative and orchestrated action and interaction of several different enzymes and auxiliary proteins. Currently very little is known about the composition and sub-Golgi localisation of such multiprotein systems. Firstly, a comprehensive insight into the interaction map of the Golgi proteome is needed. I propose to develop and apply a technique that will allow high-throughput assignment of membrane protein interactions, and identify stoichiometries. An experimental design is presented based on separation of membrane protein complexes in conjunction with state of the art quantitative proteomic approaches. Secondly, the results will be validated on selected multiprotein systems by immunoprecipitation and functional biochemical studies on knockout lines. Thirdly, the data will be used to model the interactions by protein-protein docking. The accomplishment of this project will provide new insights into the organisation and activity of the biosynthetic systems. Such insight is of great value to the production of specific polysaccharides, tailored to yield less recalcitrant mat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Pancreatic ductal adenocarcinoma (PDAC) causes 34000 deaths in the EU every year. Conventional cancer treatments have close to no impact on this disease. As a result, almost all patients diagnosed with PDAC develop metastases and eventually die. Given this poor outlook, the search for new therapeutics is mandatory. These will have to target relevant cancer pathways and be designed based on the available knowledge on the genetic alterations that characterize this malignancy. We propose to build a team composed of clinicians, translational cancer researchers, chemists, and two pharmaceutical enterprises, to synthesize and implement new drugs for PDAC. The focus of the participants in this project will be on pathways and cellular functions broadly involved in PDAC metastasis and immune escape. These drugs are meant to work through diverse and novel modes of action and will be validated using genetically engineered PDAC mouse models that we have established at the Center for Integrated Oncology in Bonn. By creating and exploring diverse classes of compounds capable of arresting tumor growth and of interfering with its metastatic spread, this project will deliver a high number of new molecules with potential as anticancer therapeutics. In particular, our consortium will produce new indoleamine 2,3-dioxygenase-2 (IDO2) inhibitors, galectin-3 inhibitors, edelfosine analogues, inhibitors of the Hippo signaling pathway, alpha-mannosidase inhibitors, SIRT6 inhibitors, and therapeutics acting by synthetic lethality. For compounds with strong proof-of-concept activity, our consortium will perform the Investigational New Drug (IND)-Enabling Studies, with the goal of delivering a new drug ready to be tested clinically by the end of the project. The PANACREAS project is meant to help
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Impact of Lipid Cell Composition on Beta-Amyloid Aggregation: Exploring Novel Therapeutic Targets for Alzheimer's Disease' (ABlina) targeting Horizon Europe.

assistant: **Abstract**

The ABlina project aims to study how cell membrane lipid composition affects the formation and deposition of beta amyloid (Aβ) aggregates. To achieve this, Molecular Dynamics (MD) simulations will be performed on membranes with varying lipid compositions, focusing on models that mimic senescent and Alzheimer's disease cells. The data generated will contribute to the establishment of a database, which will be subsequently analysed, to identify lipid patterns capable of modulating the behaviour of Aβ aggregation. If lipids promoting aggregation are identified, novel drugs could be formulated to inhibit their synthesis or interaction with Aβs, thereby preventing aggregation. Conversely, if any lipid is found to avoid aggregation, strategies could be designed to augment its presence within cerebral cells. To address the inherent spatial and temporal limitations of Molecular Dynamics (MD), Coarse-Grained (CG) modelling will be utilized. The project will be conducted at ITQB NOVA (University NOVA of Lisbon), under the supervision of Dr. Manuel N. Melo, a key contributor to the development of the original Martini Force Field, a widely recognized CG model that will be employed in this study. Through Dr. Melo's mentorship, I will receive advanced training in CG model development, enabling the accurate parameterization of lipids relevant to the project and enhancing the robustness of the database. The combination of Dr. Melo's extensive proficiency in CG methodologies and my prior experience in MD simulations and database management will establish a synergistic collaboration, expanding both my expertise and that of the host research group.Overall, my project employs an innovative approach to investigate the relationship between cell membrane composition and Aβ aggregation, potent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'PLUG-N-play passive and active multi-modal energy HARVESTing systems, circular economy by design, with high replicability for Self-sufficient Districts Near-Zero Buildings' (PLUG-N-HARVEST) targeting Horizon 2020.

assistant: **Abstract**

Conventional Retrofitting (CR) can result in high energy use reductions at the expense of high installation costs and, usually, without being able to directly perform harvesting from Renewable Energy Sources (RES). Building Automation (BA) systems, as compared to CR, can result in medium energy use reductions and in low or medium harvesting from RES at the expense of medium installation costs and medium operational costs. Recently, the concept of Adaptable/Dynamic Building Envelopes (ADBE) - such as Multifunctional Façade Modules - has been proposed towards overcoming many of the shortcomings of CR and BA. ADBE systems can result in high energy use reductions and high harvesting from RES at the expense of medium-to-high installation costs and medium operational costs. The main strategic goal of the PLUG-N-HARVEST proposal is to design, develop, demonstrate and exploit a new modular, plug-n-play concept/product for ADBE - deployable to both residential and non-residential buildings - which is able to provide high (maximum possible) energy use reductions and high (maximum possible) energy harvesting from RES both at the single-building and the district scale while requiring medium-to-low installation costs and almost-zero operational costs. Moreover, by appropriately exploiting its attributes, the PLUG-N-HARVEST system will be designed and implemented considering circular economy principles, which will allow implementing new business models based on leasing and renting modes and, by this, leaving the door open to massive implementations. Four different multi-building Pilots – in Germany, Spain, Greece and the U.K. - will be used for demonstrating the use of the integrated PLUG-N-HARVEST system in full-scale, on a 24/7 basis and for a long period. The Pilots involve buildi