RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Divergence and convergence in dialogue: The dynamic management of mismatches' to be submitted under Horizon Europe.

assistant: **Abstract**

Human interaction is deceptively simple to engage in, yet surprisingly challenging to account for theoretically.  Existing theories of language and cognition cannot fully account for the complex dynamics of verbal and non-verbal behaviours in interaction, which is becoming even more apparent with our increasing  use  of  computer-mediated  communication,  such  as  the  currently  ubiquitous  Zoom  calls.With DivCon, my vision is to transform our basic understanding of human interaction by showing how successful dialogue is driven by incremental, local and dynamic processes of mismatch management.In our everyday interactions, we continuously make predictions about what will happen next, based on how our own and others behaviour affects the world, to open up new possible courses of action.  In dialogue, these predictions are about sounds, words, inferences and even non-speech actions such as gestures or eye gaze.  If our expectations are not met, we have to ascertain if the mismatching input can be resolved, or integrated as a surprising but rewarding outcome (as in the case of humour).DivCon will produce a suite of corpus and experimental data for exploring the timely issues of communication via different forms of computer-mediated communication, including text-based chats, video calls and virtual reality meetings.  To do this, the project will create a novel experimental platform for experiments in real time live multimodal interactions using avatars and virtual reality.  The formal arm of the project will develop a precise theory of divergence and convergence in interaction which unifies verbal and non-verbal dialogue phenomena including gesture, gaze, feedback and laughter, using core notions of prediction and underspecification.  This model will be implementable in
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Biological nitrification inhibition (BNI) of the root exudates under drought stress in wheat and maize'.

assistant: **Concept**

Globally, the use of nitrogen (N) fertilizer for agricultural purposes is tremendous, with an estimated total of 120 million t/year. Due to high nitrification activity in the soil, much of the N applied to farmland (about 70%) is not absorbed by the crops and gets washed out, resulting in water pollution and the emission of nitrous oxide (N2O), a powerful greenhouse gas (298 times CO2 global warming effect). Suppressing the nitrification rate of agricultural soil could be a sustainable solution. Plant roots can exudate natural compounds that prevent nitrification, a process known as biological nitrification inhibition (BNI). Wheat and maize are staple cereals that require excess fertilizers, and their efficiency has not increased to meet future food demand since 1980. The main aim of this study is to screen root exudates secondary metabolites of diverse wheat and maize genotypes for their BNI compounds and also evaluate the BNI potential under drought stress. Even though wheat and maize are major cereals covering the largest area among food crops, the study of its root exudates and the potential presence of BNI compounds and related BNI capacity have scarcely been studied. Consequently, the discovery possibility of new BNI compounds remains minimally explored in these crops, and root exudate plasticity in response to environmental changes is still extremely limited. The evaluation and selection of crop varieties lowers the nitrogen fertilizer dependency and is suitability for sustainable agriculture translates into specific key activities; 1) biochemical characterization of agronomic and environmental traits of the germplasm collection, 2) measurement of secondary metabolites in root exudates of germplasm lines in glasshouse under drought stress conditions to explore th
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'MicroRNAs, genomic evolution and the emergence of anatomical complexity' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The embryological and evolutionary origins of anatomical complexity have been the subject of debate and speculation since the time of the ancients. Large-scale comparative genomic analyses have begun to yield tantalising secrets concerning the mechanisms by which anatomical complexity has emerged. However, this field has recently undergone an epiphany with the realisation that much of the ‘tool-kit’ (i.e. the transcription factors and signalling systems) of more anatomically complex animals such as vertebrates is found in relatively more simple taxa like cnidarians and sponges. Leaving researchers to wonder what accounts for the dramatic increase in anatomical complexity of protostomes and deuterostomes in comparison to sponges. This proposal plans to investigate the evolution and functional constraints of microRNAs, a class of non-coding regulatory elements that lie within a section of the genome originally labelled ‘junk DNA’. However, rather than being ‘junk’ microRNAs have been shown to play important roles in animal development with their misexpression being associated with a variety of medical conditions including, cancer and heart disease. My proposal for an International Outgoing Marie Curie Fellowship aims to provide me with world class training to underpin a world class career researching the fundamental question of how anatomical complexity is coded in the genome, and how that coding has evolved through evolutionary history. This will be realised by gaining skills and techniques lacking in the EU. I outline a programme of research that will act as a vehicle for this training, on which I will be able to make the subsequent steps in realising my aim of establishing my own research laboratory. In the interim, this Fellowship will also foster an international col
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'A CutFEM Paradigm for Surgical Guided Growth of Bone Joints' (CutGrow) under Horizon 2020.

assistant: **Objectives**

Many children suffer from bone deformities, which severely hinders their ability to walk. Some children may require invasive surgical treatment, such as cutting their bones, whilst others may recover their mobility through less invasive treatments such as guided growth surgery. However, surgeons have difficulties choosing the best treatment options because there is no reliable tool to help them predict the post-operative evolution of bone joints. CutGrow aims to provide a numerical platform whereby bone growth will be predicted virtually. The platform will rely on a novel finite element technology, CutFEM, developed by the applicant, Dr. Claus, which circumvents the need for meshing complex geometries. This algorithmic concept will bestow numerical agility upon all steps of the simulation process, from acquiring patient-specific data to handling complex contact conditions between interacting bones, the latter being the domain of excellence of the host supervisor Prof. Erleben. In the first stage of CutGrow, a seamless and robust simulation pipeline in the specific context of bone joint mechanics and growth will be created. In a second stage, the simulation will be used as a basis to develop a unifying and highly versatile model for children’s bone growth, capable of easily handling a range of mathematical growth stimulus theories. Finally, we will specialize the developments to the context of guided bone growth and prove that the proposed modelling framework can reproduce clinical data gathered by MD Wong at Hvidovre Hospital. The CutGrow simulation environment has the potential to transform paediatric orthopaedic surgery, by providing researchers with an agile tool to investigate new treatment options virtually and to design new operation planning procedures based on r
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Characterization of transcription termination factors in mammalian mitochondria' under Sixth Framework.

assistant: **Concept**

Transcription from the mitochondrial (mt) DNA H-strand promoter (HSP) produces a polycistronic precursor RNA encompassing all the genetic information encoded in that strand. Both mt rRNA genes and 12 out of 13 mRNA encoding genes are transcribed from HSP. There is a 20-fold higher expression of the rRNA gene region relative to the downstream mRNA encoding genes which involves an attenuation phenomenon just downstream of the 16S rRNA gene. A central role in this attenuation is played by mTERF, a protein that protects a 28 bp region immediately adjacent to the 3' end of the 16S rRNA gene. The mechanism and regulation of mTERF-dependent transcriptional termination is however still largely unknown.Two works have contributed interesting data, one by the applicant (Asin-Cayuela et al, JBC, 2004) and one by the host laboratory (Falkenberg et al, Nat Genet, 2002). The first one identifies an inactive trimeric form of mTERF, and also presents evidence for a role of mTERF on the regulation of transcription initiation. The second identifies two new mt transcription factors, TFB1M and TFB2M, that can support transcription when combined with the mt RNA polymerase and the mitochondrial transcription factor A. This finding will allow us to investigate the molecular function of mTERF in a defined in vitro system.Moreover, the host laboratory has recently identified an mTERF paralogue in the human genome, TERF2. This protein is ubiquitously expressed, but little is known concerning its structure and function.The aims will be to : 1. Characterize the molecular function of mTERF in a pure in vitro system, in terms of termination activity, interaction with the transcription machinery both in transcription initiation and termination events, mechanism of monomer to trimer transition a nd com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Awareness and Migration: Organizations for bi-national family Rights Empowerment' to be submitted under Seventh Framework.

assistant: **Abstract**

AMORE (Awareness & Migration: Organizations for bi-national family Rights Empowerment) aims to bring an action-research approach to the study of migration policies and administrative practices regulating access to citizenship and residence permits. This project will focus on bi-national married families formed by a third country national (TCN) and a European Union (EU) citizen. A TCN is a citizen of a non-EU country who resides in a EU Member State, and is thus affected by a specific administrative practices and regulations. In bi-national families, these practices unexpectedly affect the EU spouse too. By focusing on the unintended consequences of migration policies for EU citizens, the question that this project addresses is at what point these policies and practices threaten family life freedom, considered a universal human right. While their problem is still largely unknown, bi-national family members are actively participating in bottom-up Civil Society associations to defend bi-national families and migrants' rights.Using the biographical policy evaluation method to achieve its goals, the project will compare different scenarios in three cities: Brussels, Strasbourg and Turin. In order to be effective and reduce variables, only one foreign nationality will be studied, namely migrants from Morocco (TCN) married to an Italian/Belgian/French citizen (UE citizen). The study of the impact of migrations policies on family members' experiences and strategies implies investigating also those public officers involved in the implementation of the administrative practices concerning these bi-national families and taking into account people from their social surroundings. After studying individual agency, the observation will be turned to associations that have competences to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Photonic metasurfaces for resource-efficient ultrathin high efficiency tandem solar cells' in the context of a Horizon Europe call.

assistant: **Objectives**

The transition towards a society based on 100% renewable energy requires massive deployment of photovoltaics of 30-70 TW until 2050. This requires huge amounts of resources, while their limited availability is already becoming apparent. A major lever to reduce resource consumption is to increase the solar cell efficiency. As best single junction solar cells approach their fundamental limits, higher efficiency can only be reached with so-called tandem solar cells, made of two or more subcells. All tandem technologies so far are based on relatively thick absorber layers, reducing resource demand compared to single junction devices by efficiency increase. There, light trapping strategies are used to maximize absorptance close to the band gap of the materials and improve efficiency by few percent relative. However, by applying advanced light trapping techniques such as nanophotonic metasurfac-es, ultrathin single junction devices with a 5-10-fold decrease in semiconductor material were realized. To reduce resource demand further, the concept of ultrathin solar cells must be extended to tandem devices. This introduces severe challenges, as not only absorption needs to be maximized within the active part, but a spectrally dependent light guiding strategy is required. Metasurfaces have shown the ability to manipulate light e.g. spectrally dependent; however, they have never been implemented into tandem solar cells. Thus, the overarching goal of PHASE is to generate a deep physical understanding of metasurfaces for ultrathin tandem solar cells and to develop process flows to implement nanopho-tonic structures into such devices with efficiencies above 30%. This will proof that the chosen tech-nology pathway can support the urgently needed energy transition. More specific, the go
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon 2020 proposal on 'EyeControl'.

assistant: **Innovation**

Today, there are more than 1.2 Million ALS  and other “locked-in” patients who cannot move or speak (due to a stroke, neurological diseases, spinal injuries, etc.).  Those patients have fully functioning cognitive abilities, but they are locked in their bodies.  EyeFree Assisting Communication Ltd. (EyeFree) plans on disruption of the ALS and locked-in assistance devices by providing EyeControl, a wearable and simple to use  communication device that offers the main required communication functionality for much less than the currently used devices (supplied mainly by Tobii).  The leading communication devices today are screen based, controlled by eye gazing on a screen, therefore requiring long training  and limiting the ability of the user to speak only when the patient is in front of the screen and the system is calibrated to the screen position! EyeControl was developed by founders related to ALS patients in order to change the reality of the “locked- in” patients by enabling any patient to communicate anytime, anywhere.  The EyeControl follows the user eye movements using an infrared camera; the camera translates the movements of the pupil  into a “joystick” and transmits them to a small computer that converts the movements into actions.  With EyeControl, we don’t use a screen; instead we rely on audio feedback, so that the user hears what he wants to say instead of seeing it on a screen.  The user has a bone conduction earphone that enables him to hear what he wants to say before transmitting it. The device enables three levels of communication ranging from a basic call for help to more complex participation in a full conversation.  The device can also connect to a smart phone/tablet via Bluetooth.  Additionally, it enables the user to hear his own language in his
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Interactome of surface proteins important for Plasmodium sporozoite gliding motility' (InteractomeMalMot).

assistant: **Innovation**

Sporozoites are the motile forms of the malaria causing parasite Plasmodium and are injected into the vertebrate host by a mosquito. Their motility is powered by the parasites own actin-myosin motor, which is connected to transmembrane proteins of the TRAP (thrombospondin-related anonymous protein) family which serve as force transmitters. This substrate-dependent locomotion is a prerequisite for tissue penetration and host cell invasion. The glycolytic enzyme aldolase was thought to be the link between actin and surface adhesins (reported in Mol Cell). However, recent data revealed that aldolase does not fulfil this role hence it is now unclear how the force is transmitted. Additionally, lack of the main surface adhesin TRAP was also found (by the host lab) to not block motility as previously reported (in Cell). Additional recent findings are challenging the model of how gliding motility works and thus highlight the importance to focus on novel proteins. One such new protein, LIMP has recently been identified in the host lab. Therefore, the principal aim presented in this proposal is the identification of the molecular function of LIMP, which shows an identical phenotype to TRAP. To this end I will generate a series of parasites strains expressing different mutated versions of LIMP which will be investigated using biophysical approaches. Moreover, I attempt to identify the proteins interacting with LIMP.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Starting Investigator Research Grant' to be submitted under Seventh Framework.

assistant: **Abstract**

The SFI Starting Investigator Research Grant (SIRG) Programme provides an opportunity for excellent early-career-stage investigators to carry out independent research in the fields of science and engineering that underpin biotechnology, information and communications technology, and sustainable energy and energy-efficient technologies. The award also provides funding for a postgraduate student, who will be primarily supervised by the Starting Investigator (SI). The SI will work with an associated mentor, who will provide the necessary support and infrastructure for the project to take place.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Functional materials for fast diagnosis of wound infection' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Early detection of an incipient wound infection is a challenge for the attending physician ,  since its early diagnosis allows the timely initiation of treatment, thus reducing the severity of the disease . Currently, however, wound infection is not diagnosed until becoming already evident. As a consequence, the treatment of the patient is further complicated and more likely to have a negative outcome4. Often wounds are treated with antibiotics before even the infection appears, leading to overdoses and development of bacterial resistance to antibiotics.Considering that optimal efficiency is reached when a material serves multiple functions without compromise, consortium partners have discovered the means to convert wound dressings into a diagnostic tool capable to inform both patient and therapist about the wound status, thus directing towards the following therapeutic step. The proposed functional materials include a real time diagnostic reaction that positively influences the wound healing due to the timely intervention to treat infection or proteolytic stasis in the woundThe novel InFact technology will be translated into a low-cost, real-time diagnostic tool as a constituent part of a wound dressing material, i.e. the ""triple-P"" materials concept:-Protective - by a decoy substrate for destructive proteases-Predictive – providing a cumulative wound status signal to predict the infection transition-Proactive - changing the dressing according to a signal, rather than on a schedule base, will provide therapeutic response in time, and not too late.More specifically, the functional materials (e.g. absorbent fibres and hydrocolloid pads) will incorporate immobilized substrates for three enzymes: myeloperoxidase, lysozyme and elastase. Upon infection, these enzymatic act