RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'FLUORESCENT ROTORS FOR IMAGING VISCOSITY IN CELLS' under Seventh Framework.

assistant: **Concept**

This project proposes to design and synthesise a series of novel fluorescent molecular rotors able to measure microviscosity of cellular domains based on the fluorescence lifetime. The fluorescence detection is an efficient and direct way to localise the molecules within cells whereas the measurement of the fluorescence lifetime provides a number of additional assets since the fluorescence decay is typically sensitive to the environment of the fluorophore. In molecular rotors the lifetime can be correlated with viscosity of their immediate environment. Besides, fluorescence lifetime is concentration independent and allows to account for the aggregation phenomenon, and other detrimental quenching processes, the data which is unavailable from the simple intensity measurements. As such, lifetime based detection of molecular rotor fluorescence will provide a quick and accurate measure of the microviscosity in individual cell domains, unavailable from other methods.The new molecular rotors, with incorporated substituents to achieve extensive electronic conjugation, will have advantageous spectroscopic properties, such as high two-photon absorption cross sections and red-shifted absorption and emission wavelengths in the tissue therapeutic window, important both for diagnostic and therapy. These new superior dyes will be used for viscosity imaging in cells, with the emphasis on measuring the viscosity of hydrophobic membranes and on the monitoring of the viscosity changes during Photodynamic Therapy (PDT), a light activated cancer treatment of clinical importance.This project has the ideal overlap of experience and expertise between the applicant and the host group. The results will be both of fundamental importance and practical significance, e.g. for the development of futu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Improved material quality and light trapping in thin film silicon solar cells'.

assistant: **Concept**

In this project we will increase the efficiency of thin-film silicon solar cells on flexible substrates by solving the issues linked to material quality, interface properties and light management, thus enabling lower production costs per Watt-peak. The general technological objectives of the project are the development of better materials and enhanced interfaces for thin film silicon solar cells, and to transfer the developed processes to an industrial production line. The most important project goals are: 1) Reduction of optical reflection and parasitic absorption losses: Design and industrial implementation of textured back contacts in flexible thin film silicon solar cells. 2) Reduction of recombination losses: Development and implementation of improved silicon absorber material. 3) Reduction of electric losses: Graded TCO layers which minimize the work function barrier between the p-layer and the TCO layer without loss of conductivity and transmission of the TCO. In addition, the top layer of the TCO stack should provide a good protection against moisture ingression. In order to achieve these objectives more in-depth knowledge is needed for several relevant key areas for thin film silicon solar cells. The main scientific objectives are: 1) Identification of the ideal texture for the back contact. This structure should maximize the light trapping in thin film silicon solar cells without deterioration of open-circuit voltage and fill factor. 2) Paradigm shift for the growth of microcrystalline silicon. In this project we want to show that it is possible to use microcrystalline silicon with high crystalline fractions leading to better current collection without voltage losses, and without crack formation when grown on nano-textured substrates. 3) Deeper understanding o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Scanning chemical microscope' to be submitted under Fourth Framework.

assistant: **Abstract**

Since the discovery of the Scanning Tunnelling Microscope (S.T.M.), many other Microscopes were developed to probe surfaces. All these microscopes are based on different interactions between tip and surfaces. If apparatus such as Atomic Force Microscope (A.F.M.) Allows the investigation of surfaces, giving information on frictional properties, topographic aspects for example, it would be interesting to further develop the Scanning Probe Microscope (S.P.M.) towards the Scanning Chemical Microscope (S C.M.). An effort of this kind is justified since now science becomes more and more interested in the nanomanipulation and the observation of chemical and physical phenomena at the macromolecular and atomic scales such as synthetic and natural polymers. Because of their non-conducting properties, Scanning Tunnelling Microscope can't be used to probe these surfaces. And if Atomic Force Microscope is more suitable for these kind of samples, it doesn't give any information on chemical nature or functionality of the molecular groups and atoms. To obtain chemical recognition we must put a specific interaction, such as hydrogen bonding, electrostatic interaction, between the tip and the substract. Therefore the subject proposed consist to modified tips, used in Atomic Force Microscopy, according to different synthetic strategies based on the use of Self Assembling Monolayers (SAMs), to obtain the chemical picture of the surface, and by the way to develop a new kind of apparatus: The Scanning Chemical Microscope. Preliminary work on the proposed subject has recently been highlighted in Pour la Science", the French edition of the Scientific American: B. Gauthier-Manuel, L. Garnier et M. Doreau, "levitation" Pour la Science 213 p 12 (1995). Garnier was responsible for the particular e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Development of hybrid tip-enhanced IR-Raman microscopy for the study of molecular optomechanical upconversion' (TERRaMoOn) targeting Horizon Europe.

assistant: **Abstract**

Optical control of mechanical oscillators of widely different dimensions are all described by the same cavity optomechanics interaction between phonons and photons inside a cavity. In the previous decades, various research groups leveraged on this interaction to cool the mechanical oscillators to its ground-state and to produce and detect quantum states of light.The applicant wants to take advantage of mechanical modes that are deeply in their ground state at room temperature, namely vibrational modes of molecules with resonance frequencies in the IR to THz frequency range (between 1-100 THz) to explore the novel molecular optomechanical frequency conversion process (m-OMC). The key idea of the process consists in upconverting a weak IR signal into the visible domain via molecules (with modes both Raman and IR active) placed onto metallic nanoantennas, opening the whole toolbox of visible field manipulation and detection to electromagnetic fields in the IR range. The goal of TERRaMoOn is to study the m-OMC process with a hybrid near-field microscope, where the near-field probe (metallic atomic force microscopy (AFM) tip) takes over the role of one of the antennas. In the near-field microscopy approach, the tip-antenna configuration can be tuned in-situ offering unprecedented versatility to the m-OMC process and enabling to access fundamental insights that would be inaccessible to typically studied on-chip devices. m-OMC could also lead to a new modality of near-field microscopy, where IR modes could be imaged with nanoscale spatial resolution and with exceptional sensitivity by making use of the frequency conversion process. The molecular layers studied during the project will finally enable the first unambiguous measurements of vibrational strong coupling via a Raman e
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Regulation of mammalian iron metabolism by oxidative stress' (1994-1998) under Fourth Framework.

assistant: **Objectives**

In the proposed research plan, we intend to study physiological and mechanistic aspects of the response of IRP-1 to oxidative stress. By employing different agents which cause oxidative stress to cells, we will compare the effects of extracellular and intracellular oxidative stress on IRP-1. For this, we need to measure extra- and intracellular H2o2 levels. A highly sensitive chemiluminescent assay will be applied for the determination of H2o2 in the tissue culture supernatant (Mueller and Arnhold, 1995), while intracellular levels of H2o2 will be assessed by FACS analysis, using a fluorescent redox- sensitive probe. These tools will enable a detailed characterisation of the effects of H2r2 on IRP-1. In our previous work, we have provided evidence that extracellular H2o2 causes an accelerated turnover of the 4Fe-4S cluster, possibly via a signaling pathway. We now propose to further address this hypothesis, aiming to elucidate the underlying mechanism. This would require to establish an in vitro system to recapitulate the effects observed in intact cells. Such a system would enable us to dissect the early steps of the H202-response from the actual removal of the 4Fe-4S cluster. Furthermore it would provide a framework to isolate and biochemically characterize possible cluster- destabilizing activities. Training, content (objective, benefit and expected impact) The goals of this project lie within the interests of the host lab. The choise of this host lab is appropriate, as my previous training at EMBL on modern techniques of molecular biology will be meaningfully complemented by the expertise and know-how of Dr. Papavassiliou's lab. In addition, I believe that I could contribute with my knowledge in the undergraduate as well as graduate programmes of the Medical School
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Combined Spatial-Temporal Models and Decadal Climate Predictions for Tuna Fisheries' under Horizon Europe.

assistant: **Concept**

Tuna, a cornerstone of global fisheries, representing 10% of marine catches and sustaining numerous jobs, confronts pressing challenges from overfishing and climate change. To address these issues comprehensively, our proposal outlines a three-fold strategy: 1 - Advanced Spatial Modeling: We will employ Bayesian spatial models, specifically INLA (Integrated Nested Laplace Approximation), to predict tuna catch and price dynamics while considering vital environmental factors. This approach will unveil intricate relationships between catch, prices, and environmental variables, providing a deeper understanding of the complex interplay; 2 -Climate-Based Predictions: Building upon the insights gained from our spatial models, we will integrate predictions from the Norwegian Climate Prediction Model (NorCPM). This integration will allow us to provide skillful forecasts for tuna catch and price fluctuations over the next decade. These forecasts are invaluable for anticipating and responding to dynamic changes in the tuna industry, enhancing its resilience; 3 - User-Friendly Web Application: In collaboration with experts from ICES (International Council for the Exploration of the Sea) and the Norwegian IMR (Institute of Marine Research), we will develop a user-friendly web application. By developing this tool, we aim to make our scientific insights accessible to a wide audience, including researchers, managers, and policymakers. This project not only enhances our understanding of tuna fisheries and climate vulnerabilities but also empowers coastal communities, supports sustainability, and aligns with the Sustainable Development Goals. Our commitment to open-science practices ensures lasting impact through readily available project code and results.


**Keywords:** Spatial Tempora
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Rational Design of Photoreceptor Mutants with Desired Photochemical Properties' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

From a technological viewpoint photoreceptor proteins, the light-sensitive proteins involved in the sensing and response to light in a variety of organisms, represent biological light converters. Hence they are successfully utilized in a number of technological applications, e.g. the green-fluorescent protein used to visualize spatial and temporal information in cells. However, despite the ground-breaking nature of this utilization in life science and other disciplines, the attempts to design a photoreceptor for a particular application by protein mutation remains an open challenge. This is exactly the scope of my research proposal: the application of multi-scale modelling for the systematic design of biological photoreceptor mutants.With this target in mind I will study representatives of two prominent photoreceptor proteins subfamilies which are of towering interest to experimentalists: proteorhodopsins and cyanobacteriochromes. Computer models of these proteins will be constructed using accurate multi-scale modeling. Their excitation energies and other properties (e.g. excited-state reactivity and efficiency) will be calculated using multireference methods that were shown to have an accuracy of <3 kcal/mol. The insights gained from simulations of the wild-type proteins will provide the basis for proposing mutations with altered photochemical properties: in essence to predict absorption and emission spectra, excited-state lifetime and quantum yields. This research requires interactions across the disciplines, as the best candidates will be synthesized and characterized experimentally by collaborators. The outcome of these experiments will provide feedback to improve both the properties of the mutants and the simulation methodology. Ultimately this high-risk/high gain
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Strengthening User Networks for Requirement Investigation and Supporting Entrepreneurship' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The successful implementation and evolution of the EU GNSS Programmes requires a continuous involvement of users. This also ensures that user needs are fully taken into account when developing applications, helps promoting EU GNSS technology and fosters related business development.To that aim, SUNRISE proposes to establish User Fora addressing the two major markets for GNSS-based applications: Intelligent Transport Systems (ITS) and Location–Based Services (LBS). Other domains such as aviation, maritime transport or agriculture will be addressed too.The main objectives of each User Forum will be to:•Federate the user community of GNSS stakeholders comprising the whole value chain;•Encourage this user community to cooperate in order to collect, consolidate and share views and formulate requirements;•Issue advice and recommendations to the GSA and the European Commission on technical issues, business development, regulation and standardisation;•Promote innovation and increase awareness of European GNSS Programmes and applications;•Become, beyond the project, an interlocutor vis-à-vis the GSA, the EC and other authorities.A permanent user Interface platform called ‘Open GNSS Service Interface Forum’ will be set up by SUNRISE to support User Fora and will be operated during the 3-year duration of the project.In addition to the natural exchange of information and increase of awareness of each user community through the User Fora, specific promotional and dissemination actions will be carried out and will, among others, feed the EGNOS and future Galileo Web Portals.The Consortium is lead by FDC which has a sound experience in GNSS and European project management. It covers all the application domains with ERF, ETSI and bavAIRia (ENCADRE) as well as innovation and business de
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Harnessing Cavitation for Therapy' (TheraCav).

assistant: **Innovation**

Focused Ultrasound Surgery (FUS) is rapidly emerging as a technique setting the gold-standard for the treatment of a wide range of diseases, including cancer. Current practise relies on the conversion of acoustic energy to thermal, for localised and minimally-invasive ablation with non-ionising radiation. Cavitation (the formation, and subsequent pressure driven dynamics, of bubbles) is a common occurrence at the high intensities typically employed for FUS. The extremely rapid, often violent evolution of cavitation in tissue exposed to focused ultrasound, poses a high risk of collateral damage to healthy tissue proximal to the site of pathology. TheraCav will demonstrate cavitation can be controlled and harnessed, to redefine the remit of FUS to include targeted drug delivery and rapid ablation formation via enhanced heating. Conceptually, cavitation could act to significantly permeabilise targeted tissue, rendering specific volumes highly susceptible to drug delivery through extravasation from the vasculature. Moreover, cavitation may actively pump and promote drug transport directly to the diseased tissue. If cavitation is to fulfil this potential, however, it is crucial that precise monitoring and control strategies are developed, demonstrating that it can be safely introduced and utilised tissue. Through a series of novel and ambitious objectives, TheraCav will develop techniques and devices to deliver this capability, calibrated against a recent innovation that has allowed the direct observation of cavitation at unprecedented spatial and temporal resolution. A series of translational work packages will test the monitoring and control strategies developed, in tissue-mimicking materials and ultimately soft-embalmed cadaver models, for anatomical verification.Finally,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'SmartClot: Personalized platform for the combined evaluation of platelet and coagulation factor in haemostasis or during antithrombbotic therapy'.

assistant: **Concept**

Today there is a big concern about cardiovascular diseases (CVD); because each year, it causes 3.9 million deaths in Europe and over 1.8 million deaths in the European Union. With almost 49 million people living with cardiovascular disease in the EU, these problems have a huge impact on public health and on health and economic resources, with a total cost of € 2.10 billion/year. Unfortunately, over the last 25 years the number of cardiovascular diseases cases has increased in Europe. The current medical devices monitor just platelet aggregation or coagulation providing inaccurate estimations and in consequence observing insufficient therapy in thrombosis treatment or excessive therapy dosage in bleeding cases in individual patients. In response, we at SEDICIDODICI have developed, SMART CLOT, a cutting-edge technology for the combined evaluation of coagulation and platelet function for monitoring i) haemostasis (process which causes bleeding to stop, keeping the blood within a damaged blood vessel) as diagnosis tool and ii) antithrombotic treatment to control patients with diseases such as cardiovascular diseases, hypertension, thrombosis, diabetes, pulmonary embolism. It is a user-friendly, automated and real-time platform that provides qualitative/quantitative information based on an instrument and an array of multifunctional flow cartridges designed to interrogate specific pathways of both coagulation and platelet activation under relevant arterial and venous flow conditions. Before reaching market maturity we need in Phase 1 to run a Feasibility Study that helps us organise technical, commercial and financial plan of the project. Finally, SMART CLOT will bring an effective platform for the diagnosis and antithrombotic treatment. SEDICIDODICI will concentrate on the g