RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Deep non-invasive imaging via scattered-light acoustically-mediated computational microscopy' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

Optical microscopy, perhaps the most important tool in biomedical investigation and clinical diagnostics, is currently held back by the assumption that it is not possible to noninvasively image microscopic structures more than a fraction of a millimeter deep inside tissue. The governing paradigm is that high-resolution information carried by light is lost due to random scattering in complex samples such as tissue. While non-optical imaging techniques, employing non-ionizing radiation such as ultrasound, allow deeper investigations, they possess drastically inferior resolution and do not permit microscopic studies of cellular structures, crucial for accurate diagnosis of cancer and other diseases.I propose a new kind of microscope, one that can peer deep inside visually opaque samples, combining the sub-micron resolution of light with the penetration depth of ultrasound. My novel approach is based on our discovery that information on microscopic structures is contained in random scattered-light patterns. It breaks current limits by exploiting the randomness of scattered light rather than struggling to fight it.We will transform this concept into a breakthrough imaging platform by combining ultrasonic probing and modulation of light with advanced digital signal processing algorithms, extracting the hidden microscopic structure by two complementary approaches: 1) By exploiting the stochastic dynamics of scattered light using methods developed to surpass the diffraction limit in optical nanoscopy and for compressive sampling, harnessing nonlinear effects. 2) Through the analysis of intrinsic correlations in scattered light that persist deep inside scattering tissue.This proposal is formed by bringing together novel insights on the physics of light in complex media, advanced
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Molecular mechanisms of presynaptic plasticity' to be submitted under Horizon 2020.

assistant: **Abstract**

The ambitious goal of this project is to reveal the molecular mechanisms of presynaptic plasticity in the vertebrate brain. Synaptic plasticity occurs in the form of alterations in both presynaptic neurotransmitter release and postsynaptic receptor function. However, due to technical reasons and in contrast to intensely studied postsynaptic plasticity, the presynaptic half of the brain’s synaptic plasticity remains enigmatic. This is a crucial knowledge gap for our understanding of learning and memory.My ambitious aim is therefore to uncover the molecular and biophysical mechanisms of presynaptic plasticity. Building on my strong track record in presynaptic research, my group made a technical breakthrough by establishing patch-clamp recordings from small nerve terminals of cultured neocortical neurons with unprecedented high resolution. In addition, we use an innovative super-resolution-microscopy approach resolving the rearrangement of proteins within the presynaptic neurotransmitter release site, which allows high-throughput screening of all major classes of synaptic genes for their involvement in presynaptic plasticity. To reveal the neuron- and plasticity-type specificity, the identified molecular pathways will be analysed in different types of neurons in culture and acute brain slices. Building on these unique abilities, I will also investigate physiological and pathophysiological modulations of presynaptic plasticity. Specifically, I will test the hypothesis that metabolic constraints regulate presynaptic plasticity and that the amyloid pathology of Alzheimer’s disease impacts presynaptic plasticity.Thus, for the first time in the history of neuroscience, neocortical nerve terminals can be investigated with direct electrophysiological recordings and super-resoluti
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Biomechanics and signaling in models of congenital heart valve defects'.

assistant: **Objectives**

Mechanical forces are fundamental to cardiovascular development and physiology. The interactions between mechanical forces and endothelial cells are mediated by mechanotransduction feedback loops. My lab is interested in understanding how hemodynamic forces modulate cardiovascular function and morphogenesis. Overall, our recent work is unraveling the biological links between mechanical forces, mechanotransduction and endothelial cell responses. The heart beats 2.6 billion times in a human lifetime and heart valves are amongst the most mechanically challenged structures of the body. The cardiac valves are made of endocardial cells (EdCs) and extracellular matrix components. Most valve diseases have their origins in embryogenesis, either as signs of abnormal developmental processes or the aberrant re-expression of fetal gene programs normally quiescent in adulthood. This project is directed towards the elucidation of the biomechanical mechanism of mechanotransduction at the subcellular and molecular level and in addressing how EdCs integrate this information to form and maintain a functional cardiac valve. We will identify the mechanosensors at work in EdCs and their roles during cardiac valve development and repair. To do so, we will implement unique optical methodologies the lab has pioneered to characterize endocardial mechanotransduction: 1) Optical tweezing combined with mechanical stress reporters to test the mechanosensitivity of EdCs; 2) High resolution live microscopy and mathematical modeling to quantify mechanical forces; 3) 3D cell lineage studies to understand how cells respond and organize during pathological valve development. We will also use high-throughput mRNA- and ChIP-sequencing to characterize the transcriptional network activated by forces. When com
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'A new metallurgical route for the on-line conversion of by-products into valuable mineral and metallic products with a reduction of co2 emissions' to be submitted under Fifth Framework.

assistant: **Abstract**

To avoid the generation of solid by-products estimated around 50 millions tons per year in Europe, the design of an original on-line metallurgical treatment is proposed. A consortium involving the steel industry, the coal based power plants (Eastern Europe), the scrap industry (SME), the cement industry and a steel engineering company will develop a clean fusion-reduction technology for converting these adequately mixed by-products into valuable mineral and metallic materials. The metallic products will be used by the steel industry (carbon and alloyed steel grades) while the mineral components will benefit to the cement industry as substitutes of the Portland clinker allowing to reduce by 25% the CO2 emissions from that sector.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Bimodal Ammonia Nuclear Thermal and Electric Rocket' (BANTER) under Horizon Europe.

assistant: **Objectives**

BANTER represents the first step towards realizing an innovative bimodal nuclear thermal and electric propulsion system in which the same fluid (i.e. ammonia) is used as a propellant for thermo-nuclear propulsion and electric thrusters and as a working fluid for the power generation system. Due to its ease of storage in non-cryogenic conditions, its presence as an in-situ resource on many targets of future space missions, and its possibility of decomposing to increase the propulsive performance, ammonia allows the development of a compact propulsion system capable of transporting tons of payloads for a wide spectrum of missions. The design and verification through analysis of a nuclear reactor implementing a new type of coolant channels and a radiator-less power generation system fed by ammonia will constitute the first phase of this process. Then, the combination of the thermolysis, catalysis, and radiolysis processes to decompose the ammonia will be studied through two experimental campaigns carried out on prototypes of the coolant channels both in a nuclear and non-nuclear environment with the aim of demonstrating propulsive performance capable of outclassing traditional chemical propulsion systems. Moreover, another phase of design, development, and testing will demonstrate the ability of a cluster of newly designed ammonia electric thrusters to operate for long periods without excessive cathode erosion, eventually with increased efficiency due to the catalytic decomposition of the propellant. Positive outcomes of the project will pave the way for developing a technology that could make Europe a protagonist of the future space race thanks to a compact, versatile, and high-performance propulsion system. In addition, any improvement in the production of green hydrogen
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'On-the-fly alterable thin-film solar modules for design driven applications' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The demand for aesthetically integrated photovoltaic materials is increasing steadily in many industries. A growing number of designers, architects and industrial manufacturers across the world share a common interest in using Photovoltaics (PV) as a decentralized and sustainable source of energy in their product designs. Developing markets such as sustainable housing, temporary building structures, outdoor activities, electro-mobility and mobile computing will drive the demand for decentralized, attractive energy solutions.For solar powered products are customisable shapes, sizes, colours, transparencies or specific electrical properties required, which have a decisive influence on the acceptance on the market. Therefore a new breed of solar technologies is necessary.To achieve this goal new flexible production processes and materials need to be developed.A novel manufacturing process will enable the adjustment of all properties of a thin-film module on-the-fly and facilitate the production of customized photovoltaic modules with the desired voltage, size and shape. Combined with the material characteristics given by the underlying thin-film solar cell technology a new-breed of design-led, sustainable and decentralised energy solutions can be realized.Furthermore the designer or architect who wants to incorporate solar electricity into his work needs a service environment to be assisted in the creative process. Tools should support the designer in conceiving, planning and producing the solar design products. This project will address the above mentioned challenges by exploring and developing new materials, manufacturing and business processes in PV powered product design and architecture.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'ICN2020: Advancing ICN towards real-world deployment through research, innovative applications, and global scale experimentation' (ICN2020).

assistant: **Innovation**

Information access on the Internet is exploding. Usage is shifting to multimedia applications, social networking and IoE. Cellular networks are moving to the next generation. Networking technology is shifting towards virtualization, with SDN and NFV likely to change the infrastructure landscape. The cloud concept is transforming the Internet to a network of data centers, with a communication model consisting of computer-to-cloud-to-computer interactions. Security concerns are leading to an encryption of all traffic, wreaking havoc with established network mechanisms.In this scenario with dramatic growth and evolution, where abstractions and interfaces become fundamental, ICN is just the perfect solution. ICN2020 will build on the wealth of studies performed on ICN with six main aims: a) design and develop a set of innovative applications such as video delivery, interactive videos and social networks to exploit ICN; b) augment ICN with IoT features and cloud/CDN/virtualization services; c) accordingly enhance existing ICN solutions/architectures; d) build local and global test-bed(s) to experiment the applications, services and ICN enhancements; e) contribute to common APIs and standards, by continuing the work that project partners are already doing; and f) Industry POCs of products and services exploiting ICN.The ICN2020 consortium includes leading experts in ICN and contributors to ICN testbeds in EU, Japan and USA, thus making the goal of federating them a credible one. Partners are also coordinators of running projects on 5G and Cloud topics, allowing fruitful cooperation with fellow projects of the EU-JP1, EU-JP2 calls and increasing the overall expected impact of the EU-Japan cooperation. In a time when 5G networks are being designed, with foreseen unprecedented f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'GPS-EGNOS based Precision Agriculture using unmanned aerial vehicles' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Unmanned Aerial Vehicles (UAVs) are an up-and-coming method in providing farmers with (near) real time sensing information for precision agriculture applications such as water stress monitoring, detection of nutrient deficiencies and crop diseases. FieldCopter provides state-of-the-art multi-spectral cameras on UAVs that deliver the right information in the right time on the right spot. The FieldCopter project develops a complete solution for UAV sensing. Existing components will be brought together and required high precision navigation of EGNOS will be added in order to create an autonomous flying camera that follows a predefined pattern.The consortium aims at a complete operational service and brings together the necessary competences assembled on the platform: the sensing aspects, the navigation expertise and the market knowledge. As the service is based on EGNOS, we can operate it anywhere in Europe. The partners combine market knowledge in the Mediterranean and higher latitudes, each with specific challenges. We will commercially exploit the results of this project in addition to the current business of the project partners. FieldCopter allows farmers to create economical and ecological benefits through optimal use of resources like water, nutrients (potassium, nitrogen) and crop protection agents. FieldCopter proves the potential of a European-wide precision navigation system and benefits from its operational continuity. EGNOS is a key enabler to develop this service.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'EUROPEAN VOLCANO OBSERVATORY SPACE SERVICES'.

assistant: **Concept**

The decision to propose EVOSS (a downstream service uniquely related to volcanic hazard monitoring) was driven by 9 institutional End Users from the EU, the Caribbean and Africa, with objective technical needs in managing 6 volcano observatories and having responsibility in current major unrests at 11 volcanoes worldwide, some of which in remote areas subjected to complex operational conditions. EVOSS, stems from the unique ensemble of phenomena, parameters and forerunners involved in volcanic unrests, and the need for responses scaled to the vastly variable intensities, durations and extent of possible eruptive activity. It capitalises on results achieved within projects GlobVolcano and PROMOTE of ESA, currently running. Its main goal is to implement the spaceborne support to volcano monitoring capacity by a substantial amount, acting at supra-regional scale and including multi-parameter tracking with temporal resolutions (multispectral EO) and spatial resolutions (Radar EO) hitherto unachieved. EVOSS, is centred on the development or the finalization of advanced data processing techniques for Gas/Ash, Thermal (high-temperature) and Ground deformation, underlain by robust theory and brought seamlessly to the End User for use in surveillance routine and emergency decision. EVOSS was designed for acting from sustained unrest on, with adaptive task scaling up to handing over the surveillance to spaceborne observation during events of outstanding areal impact, that may lead to withdraw personnel from the field or to evacuate the observatory. The integration of space-borne data in groundbased monitoring arrays (if they exist) is done at the local level. In EVOSS, the concept is voluntarily restricted to EU and Africa but can be readily extended globally by exploiting the co
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Response of Earth system to extreme palaeoclimatic and palaeoenvironmental changes: A multiproxy study of the aftermath of the Toarcian hyperthermal' demonstrating excellence, impact and implementation quality for a Horizon 2020 call.

assistant: **Abstract**

Climate change is currently one of the major challenges for our society. Observations from past time intervals marked by climatic and environmental instabilities are crucial to predict the consequences of current global warming and the feedback mechanisms that would allow the biosphere to return to steady-state conditions. The Toarcian Oceanic Anoxic Event (T-OAE, Early Jurassic) was one of the most extreme hyperthermal events in Earth history. It is well constrained that volcanic activity triggered the cascade of environmental feedbacks associated to this event, whereas the evolution in the middle–late Toarcian and the recovery phase are still poorly understood. With RECOVERY, I will fill this gap by giving a holistic appraisal of the palaeoclimatic and palaeoenvironmental evolution in the aftermath of the T-OAE and of the feedback mechanisms, which helped the biosphere to recover. RECOVERY will follow a multi-proxy approach combining sedimentological observations, and mineralogical and geochemical analysis to (i) provide a high-resolution carbon isotope stratigraphy and trace carbon cycle dynamics, (ii) reconstruct the palaeoenvironmental conditions and constrain the climate-carbon cycle feedback mechanisms, (iii) evaluate changes in nutrient level and primary productivity, (iv) track the causality link between volcanic activity and environmental changes, (v) constrain continental weathering rates and evaluate the potential impact on global climate. The originality and innovative aspects of RECOVERY builds at the intersection of advanced analytical tools and theoretical concepts to provide an unprecedented comprehensive understanding of the feedback mechanisms implied in Earth system recovery after extreme palaeoclimatic and palaeoenvironmental changes, taking the aft
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'First in class lateral meniscus prothesis to relieve pain and restore mobility for KOA patients', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

ATRO Medical developed a revolutionary prothesis that quickly relieves pain and restores mobility for severe KOA patients with a dysfunctional lateral meniscus: Trammpolin. We offer a minimally invasive, low impact procedure that postpones undesirable TKR and reduces KOA-related healthcare costs and medication dependency, while restoring full knee functioning. Our innovation is composed of a dual highly biocompatible polymer that carries the body weight and is uniquely shaped to reproduce the anatomical shape and mechanical properties of the native meniscus. The technology has proven itself for the medial meniscus and received the Breakthrough Device Designation of the US FDA in 2020. For successful market entry of our lateral Trammpolin in 2026, we aim to finalize our pre-clinical activities, conduct a FIH-study, and obtain CE-marking. In parallel we will perform a health economics analysis as a crucial step towards obtaining reimbursement for large scale uptake in the medical system.


**Keywords:** Highly compatible polymer,Native meniscus implant