RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Natural biofilms as high-tech conditioners for drinking water' (BIOFILMS) under Fifth Framework.

assistant: **Objectives**

Problems to be solvedDrinking water companies in Europe have installed sophisticated treatment facilities to prepare drinking water from moderate quality surface water. However, the quality of the 'raw' water remains important, because increasing urbanisation enhances the load of pathogens and substances with suspected hormonal, mutagenic or other health risks. Shortage of water, especially in the Mediterranean countries, implies that surface water of any quality is to be exploited. In view of these problems it is imperative for the drinking water sector to improve environmental technologies increasing water quality prior to treatment. Bio films are sites of biological activity, that abound in all natural rivers and lakes, as well as in all stages of the drinking water system. The aim of the research planned is to develop the knowledge needed to exploit bio films upstream of the water plant and to optimise their capacity to regulate organic matter content in water, to retain noxious compounds and to trap potential pathogens.Scientific objectives and approachAnalysing the practical problems of the drinking water companies and considering the basic functioning of bio films, the following research activities will be undertaken.· Construction of a dynamic model for the exchange of solutes and particles between autotrophic/heterotrophic bio films and water. The model facilitates the application of ecological, ecotoxicological and chemical information to water technology.· The basic architecture of bio films, composed of micro-algae, bacteria and their mucus envelope, and the sites of major biological activity are described and localised. Confocal microscopy is one of the tools used.· Analysis of bio film development and quantification of its capacity to trap particles from t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Understanding tumour resistance: Receptors and signalling pathways that can lead the race against tumour angiogenesis' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Anti-vascular endothelial growth factor (VEGF) therapies, such as bevacizumab, inhibit VEGF angiogenic actions and are increasingly used in the clinic as anticancer regimens for a variety of tumours, among which glioblastoma multiforme (GBM), the most lethal and angiogenic brain tumour, characterized by a high degree of heterogeneity. However, resistance to anti-angiogenic therapy, which leads to ineffectiveness of the existing drugs, is often acquired and suggests that there is urgent need to identify novel targets and develop alternative or complementary therapeutic options. Previous in vitro studies of the host lab have identified a novel receptor that binds VEGF and through co-operation with alpha v beta 3 integrin, is required for VEGF-induced endothelial and GBM cell migration. This receptor also mediates VEGF effects that are not inhibited by bevacizumab, encouraging the hypothesis that its targeting might be beneficial for at least some cases of resistance development to bevacizumab. The objectives of the current application are: 1) to study how VEGF interacts with this novel receptor in several different GBM cell lines, as well as in commercially available tissue arrays containing different grades of astrocytomas, and evaluate the physiological significance of such interaction, 2) To determine the interplay between this and other VEGF receptors/co-receptors, such as VEGFR-2, alpha v beta 3 integrin and nucleolin, and elucidate the cross-talk of their signalling pathways that subsequently activate the transcription factors NFAT and AP-1 and play a role in VEGF-induced cell migration, angiogenesis and inhibition of apoptosis. The project incorporates state of the art in vitro and in vivo approaches and is based on a multitude of disciplines, in order to validate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'A new COlloidal cybernetIc sysTem tOwaRds 2030', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

COGITOR represents a novel approach to cybernetics, proposing the study of Colloidal (liquid) Cybernetic Systems (CCS), a multifunctional liquid-based platform that we have designed to be capable of pressure sensing (i), computing and data storage (ii), energy harvesting (iii) and integrating fully custom electronics (iv). A CCS provides operation in extreme environments by definition, having distributed architecture (homogeneous liquid plus random network architecture), being fault-tolerant and featuring self-healing capabilities. Within COGITOR in 54 months the consortium will provide a platform where liquid electronics efforts can converge from all over the world, making European research the point of reference for this big step forward. COGITOR measurable and specific objectives are: i) creating an impedance liquid state pressure sensor with spatial and temporal resolution; ii) producing an holonomic reversible memory written/erased electrically and read by tomographic Microwave Impedance Spectroscopy; the electrical operation will be used to implement learning (both sequential and concurrent) and calculation, where the system acts as a many-input Boolean circuit; iii) harvesting energy from a thermal gradient artificially induced by IR radiation upon the prototype; iv) integration and testing of the final CCS prototype, testing self-healing and fault tolerance capabilities, as well as assessing interference, also under EE conditions varying T, p and B. The engineering applications that we plan to exploit will be part of the intellectual property of a spin-off company. The consortium is well-balanced with cutting edge Research Organizations across EU (IIT – Italy, UWE – UK, EMPA - Suisse) and companies (PC – Germany, PNO – Spain) that will closely collaborate to dev
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Pyrolytic Advanced Process for Energy and Recycling' (PAPER).

assistant: **Innovation**

The purpose of PAPER is to demonstrate a pyrolysis plant running on a industrial scale to take advantage of the energy generated by waste derived from the production of recycled paper and which is applicable to any waste of similar characteristics. The waste is generated during the industrial processes of breaking down and purifying the paper pulp obtained from used paper. 80% of the cellulose is recovered and the waste generated consists fundamentally of polyethulene, aluminium (from liquid board packaging) and a small amount of fibre. The industrial pyrolysis plant will be designed to treat 36.000 ton per year of waste in order to produce steam that will be used directly in the manufacture of recycled paper or will be sent to a condensation steam turbine generating electricity.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Exploring the gamma-ray sky: binaries, microquasars and their impact on understanding particle acceleration, relativistic winds and accretion/ejection phenomena in cosmic sources' (GAMMARAYBINARIES) targeting Seventh Framework.

assistant: **Abstract**

The most energetic photons in the universe are produced by poorly known processes, typically in the vicinity of neutron stars or black holes. The past couple of years have seen an increase in the number of known sources of very high energy gamma-ray radiation from a handful to almost 50, thanks to the European collaborations HESS and MAGIC. Many of those sources are pulsar wind nebulae, supernova remnants or active galactic nuclei. HESS and MAGIC have also discovered gamma-ray emission from binary systems, finding that some emit most of their radiation at the highest energies. Expectations are running high with the December launch of the GLAST space telescope which will provide daily all-sky information in high energy gamma-rays with a sensitivity comparable to that achieved in years by its predecessor. I propose to explore the exciting observational opportunities in high energy gamma-ray astronomy with an emphasis on non-thermal emission from compact binary sources. Binary systems are intriguing new laboratories to understand how particle acceleration works in cosmic sources. The physics of gamma-ray emitting binary systems is related to that in pulsar wind nebulae or in active galactic nuclei. High energy gamma-ray emission is the result of non-thermal, out-of-equilibrium processes that challenge our intuitions built upon everyday phenomena. The particles are billions of times more energetic than X-rays and can reach energies greater than those in particle accelerators. Binary systems offer a novel, constrained environment to study how the cosmic rays that pervade our Galaxy are accelerated and how non-thermal emission is related to the formation of relativistic jets from black holes (accretion/ejection). The study requires a combination of skills in multiwavelength o
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Engineering Catalytic Membraneless Organelles for CO2 Fixation' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

In recent years, membraneless organelles were shown to be intracellular liquid like condensates formed through phase separation. Following their discovery, they have been found across all kingdoms of life. For some of these organelles, a crucial role in cellular physiology has been determined, while for many others their true function remains unresolved. Recently, it has also emerged that the pyrenoid, which concentrates the CO2 fixation machinery of photosynthesis, behaves like a liquid non-membrane bound organelle in green algae. However, the pyrenoid and its forming protein EPYC1 undergo a complicated assembly in vivo, which poses a challenge for the functional understanding, engineering and transplantation of pyrenoids. Here I propose to use a bottom-up strategy to assemble and evolve pyrenoid formation de novo. To paraphrase the renowned physicist Richard Feynman – “What I cannot create, I do not understand” – I plan to mimic the formation of pyrenoids by fusing liquid-liquid phase separating (LLPS) intrinsically disordered peptides (IDP) to RuBisCO to create artificial pyrenoid-like condensates in vitro (objective 1). From the RuBisCO-IDP library, I will select the best performing condensate for transplanting into S. elongatus to generate an artificial pyrenoid. Subsequently, I will compare this strain with the wild-type and a carboxysome knock-out strain (objective 2). Finally, I will evolve the RuBisCO-IDP and the corresponding strain for enhanced photosynthesis (objective 3). My experiments will inform on the evolutionary differences between different carbon concentrating mechanisms (CCM), on the biochemical mechanisms underlying a liquid-liquid phase separated CCM and will show whether and how CCMs can be engineered towards improved photosynthesis. This projec
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Compact hot gas clean-up system for particulate removal phase - 1'.

assistant: **Innovation**

Advanced power generation cycles from solid fuels can contribute significantly to future European energy security and require particle-clean combustion/gasification product gases at high temperatures in order to achieve at the same time significant energy efficiency and environmental benefits. State-of-the-art hot gas particle clean-up technology is typically based on ceramic candle filters (rigid and soft), and to a lesser extent on smaller, one piece honeycomb cross-flow filters The technology is still in a stage far from providing reliable and cost-effective particulate removal from hot gases Major problems areas involve: mechanical failure due to ash particle bridging, filter thermal stability and materials compatibility issues, system price due to high candle filter weight and manufacturing cost and appreciable pressure drop, to name a few. The objective of the proposed research is to develop a compact hot gas particulate clean-up system by integrating three specifically tailored, advanced high temperature ceramic materials (Silicon Carbide, high strength Cordierite and Aluminum Titanate) into a novel, and cost-effective filter design, so as to overcome problems with current candle technology. The system to be developed will have the following characteristics compared to a similarly sized candle-based system: 1. Considerable increase in mechanical strength 2. Higher operating temperature 3. Considerably lower pressure drop with filtration efficiency as high as 99.998% 4. Half the system weight for the same volume 5. More than double the filtration surface to volume ratio 6. Considerably reduced system price 7. No foreign patent dominance The proposed hot gas filter system consists of a filter vessel having a gas inlet and outlet section, a filter cleaning device (a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CMRF35-like molecules: a novel receptor family involved in the control of myeloid cell function' (2002-2006) under Sixth Framework.

assistant: **Objectives**

Cells of the myeloid lineage are the major cellular component of the innate immune system. They orchestrate the adaptive immune response and play a major role in inflammatory pathologies and tumour progression. Given these facts, a more thorough understanding of the control of myeloid cell function is clearly warranted.Our proposal aims to address this problem directly, by investigating a newly identified family of myeloid receptors. This family is orthologous to a previously identified human receptor, CMRF-35A, and we have thus named them CMRF-35 like molecules (CLM). CLMs are expressed predominantly by myeloid cells.Our initial studies have been focused on one receptor, CLM-1 and suggest that CLM-1 can block osteoclastogenesis at an intermediate stage of differentiation. Because of the evident and implied importance of this receptor family in the regulation of myeloid cells, I am interested in pursuing studies of their function.The studies will be focussed in the following areas:- Complete definition of the CLM receptor family. Initial studies will focus on a more thorough definition of the receptor family in terms of cell and tissue expression.- Signal transduction studies. We will first attempt to define proteins associating with select CL M receptors, and will use cytoplasmic domain mutants to further delineate signalling pathways engaged by these receptors.- Ligand identification. A key to determining receptor function is identification of the receptor ligands. This is a particularly challenging task, and to increase chance of success we will use a number of novel library-based approaches.- Functional studies. Even prior to ligand identification, we will use monoclonal antibodies to initiate functional studies of the CLMs. These will be influenced by cell expressi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Developing Structure-Reactivity Relationships of the Zeolite Catalysed Bio-alcohol Mediated Aromatic Alkylation Processes via a Multi-Spectroscopic Investigative Approach' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

A top priority of the European Union under the Horizon 2020 protocol is that chemical industries must reduce their dependence on fossil fuels. In the petro-chemical industry, aromatic alkylation processes using olefins as alkylating agents and zeolites or inorganic Lewis acids as catalysts are still exclusively depending on fossil fuels. Other limitations of these processes include corrosion, toxicity, contamination and undesired side reactions. Hence, I will develop new zeolite-based catalytic technologies for the alkylation of aromatics using bio-alcohols (derived from biomass) as alkylating agents. Here I hypothesize that MWW type medium pore zeolites and MTW/MOR type large pore zeolites are ideal catalysts for aromatic alkylation using short and long chain alcohols, respectively. In this regard, the specific project aims are: (1) evaluation of these specific medium and large pore zeolites for the production of alkylated aromatics with high selectivity and purity in bio-alcohol mediated aromatic alkylation processes, (2) proper process optimization by tuning all reaction parameters in order to achieve excellent selectivity at reasonably higher reactivity and (3) elucidation of the catalytic cycle and deactivation mechanism and establishment of the structure-property-function relationships through the application of advanced in situ/operando (micro-)spectroscopic techniques. Altogether, the acquired knowledge from this research project will help the chemical community to design future catalyst materials for bio-alcohol mediated aromatic alkylation processes.    This project will be carried out within Inorganic Chemistry and Catalysis (ICC) group at Utrecht University under the supervision of Prof. Bert M. Weckhuysen. This will allow me to develop my knowledge and skil
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Single molecule bio-electronic smart system array for clinical testing'.

assistant: **Concept**

Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreat
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Fifth Framework proposal for the project 'Future Application of low-sulphur Marine Fuels'.

assistant: **Objectives**

To identify and document challenges for the marine industry facing future European regulation of sulphur content of marine fuels. Impact on the supply and demand balance, product mix and cost for the marine bunker market will be assessed. Need for new fuel quality standards will be analysed. Technical and operational constrains and benefits from change of fuel qualities will be investigated and technical and operational impact for engine manufacturers and ship owners presented. Technical limitations for marine engines and potential compatibility problems related to new fuel blends will be particularly considered. A recommended best practice for implementation and control of compliance of new sulphur content regulations for marine fuels will be prepared.