RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'CertiFOX: Certified First-Order Model Expansion' (CertiFOX) under Horizon Europe.

assistant: **Objectives**

The field of combinatorial optimization is concerned with developing generic tools that take a declarative problem description and automatically compute an optimal solution to it. Often, users specify their problem in a high-level, human-understandable formal language. This specification is first translated into a low-level specification a solver understands and subsequently solved. Thanks to tremendous progress in solving technology, we can now solve a wide variety of NP-hard (or worse) problems in practice. Moreover, these tools are increasingly used in real-life applications, including high-value and life-affecting decisions. Therefore, it is of utmost importance that they be completely reliable. The central objective of this proposal is to develop methodologies and tools with which we can guarantee with 100% certainty that the right problem has been solved correctly. To achieve this ambitious objective, I will build on recent breakthroughs in proof logging, where solvers do not just output an answer, but also a proof (or certificate) of correctness. However, a major limitation of current techniques is that correctness is not proven relative to the human-understandable specification written by the user, but relative to the low-level translation that the solver receives, meaning that there is no guarantee that the solver is solving the original problem. In this project, I will investigate end-to-end guarantees of correctness. When successful, this will have a major impact on the way combinatorial optimization software is developed, evaluated, and used: the proofs produced will enable (1) debugging, since proofs contain detailed information about where bugs occurred, (2) auditability, since proofs can be stored and checked by an independent third party, and even (3) ri
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'Intersections of class and ethnicity in paid domestic and care work: theoretical development and policy recommendations based on the study of 'majority workers' in Italy and in the USA'.

assistant: **Objectives**

This project is about paid domestic and care workers (PDCW) who are citizens and members of the ethnic majority of the country where they work. PDCW as a labor sector employs at least 67 million people globally and these include not only migrants but also ‘majority’ workers (ILO, 2017). This project contributes to recent scholarship on this topic – mostly focusing on workers with a minority or migrant background – by drawing attention to the workers who are white working-class women, both in the United States and Italy.In the light of the recently passed European Parliament Resolution “Women domestic workers and carers in the EU” (EPRS 2015), it is important to reflect on this labor sector as a constitutive element of employment for working-class women in many countries. More research is needed because PDCW is not only a way of “doing gender”, or  “doing” race, ethnicity, migratory statuses, but it simultaneously concerns class differences between women. A comparison between Italy (a Southern European country with a well-grounded tradition of PDCW and high levels of regulation of the sector) and the United States (a Western country of great ethnic diversity but limited regulations on PDCW) is of the greatest interest because in both of these countries ‘majority’ workers account for a substantial portion of PDCW while differing considerably in terms of legal regulations of PDCW, as well as class structure and ethnic composition. The project consists of policy and data analysis concerning PDCW in the USA, Italy and EU, and of qualitative inquiry on how the intersection of gender, ethnicity and class impact impacts on ‘majority’ workers in American and Italian PDCW. The experience of the Fellowship, academic environment of an American and Italian university and the researc
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Seventh Framework proposal on 'CAAX Protein Processing in Human DIsease: From Cancer to Progeria'.

assistant: **Innovation**

My objective is to understand the physiologic and medical importance of the posttranslational processing of CAAX proteins (e.g., K-RAS and prelamin A) and to define the suitability of the CAAX protein processing enzymes as therapeutic targets for the treatment of cancer and progeria. CAAX proteins undergo three posttranslational processing steps at a carboxyl-terminal CAAX motif. These processing steps, which are mediated by four different enzymes (FTase, GGTase-I, RCE1, and ICMT), increase the hydrophobicity of the carboxyl terminus of the protein and thereby facilitate interactions with membrane surfaces. Somatic mutations in K-RAS deregulate cell growth and are etiologically involved in the pathogenesis of many forms of cancer. A mutation in prelamin A causes Hutchinson-Gilford progeria syndrome—a pediatric progeroid syndrome associated with misshaped cell nuclei and a host of aging-like disease phenotypes. One strategy to render the mutant K-RAS and prelamin A less harmful is to interfere with their ability to bind to membrane surfaces (e.g., the plasma membrane and the nuclear envelope). This could be accomplished by inhibiting the enzymes that modify the CAAX motif. My Specific Aims are: (1) To define the suitability of the CAAX processing enzymes as therapeutic targets in the treatment of K-RAS-induced lung cancer and leukemia; and (2) To test the hypothesis that inactivation of FTase or ICMT will ameliorate disease phenotypes of progeria. I have developed genetic strategies to produce lung cancer or leukemia in mice by activating an oncogenic K-RAS and simultaneously inactivating different CAAX processing enzymes. I will also inactivate several CAAX processing enzymes in mice with progeria—both before the emergence of phenotypes and after the development of adva
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'SPATIAL NAVIGATION – A UNIQUE WINDOW INTO MECHANISMS OF COGNITIVE AGEING' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

By 2040, the European population aged over 60 will rise to 290 million, with those estimated to have dementia to 15.9 million. These dramatic demographic changes will pose huge challenges to health care systems, hence a detailed understanding of age-related cognitive and neurobiological changes is essential for helping elderly populations maintain independence. However, while existing research into cognitive ageing has carefully characterised developmental trajectories of functions such as memory and processing speed, one key cognitive ability that is particularly relevant to everyday functioning has received very little attention: In surveys, elderly people often report substantial declines in navigational abilities such as problems with finding one’s way in a novel environment. Such deficits severely restrict the mobility of elderly people and affect physical activity and social participation, but the underlying behavioural and neuronal mechanisms are poorly understood.In this proposal, I will take a new approach to cognitive ageing that will bridge the gap between animal neurobiology and human cognitive neuroscience. With support from the ERC, I will create a team that will characterise the mechanisms mediating age-related changes in navigational processing in humans. The project will focus on three structures that perform key computations for spatial navigation, form a closely interconnected triadic network, and are particularly sensitive to the ageing process. Crucially, the team will employ an interdisciplinary methodological approach that combines mathematical modelling, brain imaging and innovative data analysis techniques with novel virtual environment technology, which allows for rigorous testing of predictions derived from animal findings. Finally, the propos
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Intelligent process control for rotational moulding' (1994-1998) targeting Fourth Framework.

assistant: **Abstract**

This application has been prepared with the support of both an Exploratory Award and a Research Feasibility Study. The project aims to further the capability of rotational moulding by developing both the process, and a superior, intelligent, online control capability. The ultimate deliverable will be the development of new prototype machinery for the rotational moulding industry. The machinery will incorporate (a) innovative heating/cooling devices, and (b), the intelligent monitoring and control of the dynamics, heating and pressure involved in the rotational moulding process. The project will enable the production of higher value goods with more complex structures and faster cycles than is currently possible. It will allow the production of multi chamber, multi coloured and larger products of variable thickness, and will increase the use of new materials, such as cryogenically ground and recyclable polymers. It will permit entry into new markets in which other polymer processing methods (eg injection moulding, blow moulding) are technically unable to break into, therefore increasing consumer choice. In existing niche markets, it will also place rotational moulding with its low unit costs at a comparative cost advantage to the alternative polymer processing techniques. Due to its low start up costs, rotational moulding is dominant amongst small and medium sized enterprises in Europe (87% of companies are SMEs 1). The results of the project will have direct influence upon the core SMEs, and through its exploitation, an impact on SMEs who are not directly involved in the project. It is estimated that the project has the potential to reduce cycle times in rotational moulding by 50% and increase turnover by 33 %. It will have an environmentally positive impact, particularl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Novel Target for Treatment of Chronic Inflammatory Diseases', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Lipum AB has discovered a novel target protein for treatment of chronic inflammatory diseases. We are now developing a biological drug that will inhibit the target molecule. We propose an entirely new therapeutic mode of action as an alternative to current therapeutics that do not provide adequate response in as much as 1/3 of patients. Our research and preclinical results indicate that our approach can be applied for treatment of an array of autoimmune and autoinflammatory conditions, and that the suppression of the patient immune system can be avoided, which otherwise is a common negative side effect limiting treatment options. Currently, Lipum is focused on delivering a humanised candidate drug. Our aim is to to reach a drug development phase where toxicology and safety tests can be started and establish collaborations needed to proceed with the clinical studies. Within the lifecycle of this project, Lipum will focus on providing preclinical evidence, securing IP and reaching out to partners interested in exploitation of our approach for the treatment of Rheumatoid Arthritis and Juvenile Idiopathic Arthritis. These are chronic and debilitating conditions that affect around 1% of adult population (RA) or thousands of children (JIA) worldwide. Both RA and JIA are important cause of disability and generate high costs of healthcare and lost productivityLipum AB is a Swedish SME founded in 2010 with the aim to bring to the market a new biological drug for chronic inflammatory diseases. An effective and safe alternative has been long expected by the millions of patients that struggle with chronic and debilitating conditions like Rheumatoid arthritis (RA), Psoriatic Arthritis (PsA), or Inflammatory Bowel Disease (IBD), and by the rheumatology opinion leaders that have been
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Horizon Europe proposal on 'The Platformization of Music: Towards a Global Theory'.

assistant: **Innovation**

How are streaming and social media platforms changing the working conditions and creative practices of music artists around the world? How can we better understand the transformative impact of “platformization” through the lens of music? Online platforms - from Amazon to YouTube – have been both celebrated and criticized. The COVID-19 pandemic has only further entrenched these platforms in our lives. PlatforMuse takes music as a medium through which to examine the impacts of platformization. It offers the first cross-national analysis of this transformation as understood by music artists. To date, most research into platformization is limited to case studies of particular platforms in particular countries. PlatforMuse provides a global perspective that is sensitive to the complexity of platformization. The three national contexts that make up this project – the Netherlands, South Korea, and Nigeria – represent three very different models and stages of platformization. PlatforMuse asks: How might the everyday experiences of music artists in diverse locations challenge some of the assumptions about how platformization proceeds, and in turn, help us to generate a truly global understanding of cultural production in the platform era? The PI has extensively researched music platformization in North America, Europe and Asia and is thus uniquely suited to realize the ambitious aims of this global project. The project is embedded in a multidisciplinary research network and an advisory board comprised of academics, industry experts and artists from the Netherlands, South Korea and Nigeria. Through innovative methods PlatforMuse promises to bridge and build upon diverse fields of study; including popular music studies, platform studies, media/cultural industries research, and eth
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Sixth Framework proposal for the project 'Remodeling of Intracellular Calcium Handling in Atrial Fibrillation'.

assistant: **Objectives**

Arial fibrillation is the most common chronic arrhythmia afflicting 4% of the population over the age of 60 years. With aging of the population this incidence is going to increase. Serious complications such as emboli stroke and cerebral haemorrhage (as patients need to beanticoagulated) a high morbidity and mortality are associated with atria fibrillation with greatsocio-economic implications. Until today, however, there is no effective treatment of the arrhythmia. Chronic atria fibrillation grows more resistant to pharmacological and electricalcardioversion the longer it persists. In recent years it has been elucidated that during the time course after the initiation of the arrhythmia a complex remodelling of the atria takes place, which involves the electrical, contractile and structural properties. Electrical remodelling leads to a reduction in the atria effective refractory period and a shortening of the action potential. Contractile remodelling is characterized by a loss of 70% of atria contractile function leading to thrombus formation in the atria with the risk of emboli stroke if the thrombus dislodges. It has been shown that alteration in intracellular Ca2+ homeostasis and Ca2+ handling properties play a major role in the remodelling process. During atria fibrillation intracellular Ca2+ and Na+concentrations increase. Although major insights into the path physiology of atria fibrillation on the cellular level have been gained the actual changes in intracellular ion concentrations have never been directly measured. Changes in intracellular calcium handling strongly interact with intracellular Na+ and H+ homeostasis. Therefore this project addresses the changes in alterations in intracellular ion concentrations (Ca2+, Na+ and H+) and ion handling properties in t
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Interworking and JOINt Design of an Open Access and Backhaul Network Architecture for Small Cells based on Cloud Networks' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

Motivation. The last decades brought an exponential increase in mobile traffic volume. This will continue and a 1000-fold increase by 2020 has been forecasted. Small-cells promise to provide the required data rates through an increased spatial utilisation of the spectrum.<br/>Problem statement. Due to strong inter-cell interference, small-cell deployments will require a high degree of coordination as offered by centralised processing. Furthermore, heterogeneous backhaul solutions will be used to connect small-cells and core network. So far, access and backhaul are individually designed and therefore not optimised. In order to support centralised processing and a heterogeneous backhaul, challenges on access and backhaul must be simultaneously tackled.<br/>Approach. iJOIN introduces the novel concept RAN-as-a-Service (RANaaS), where RAN functionality is flexibly centralised through an open IT platform based on a cloud infrastructure. iJOIN aims for a joint design and optimisation of access and backhaul, operation and management algorithms, and architectural elements, integrating small-cells, heterogeneous backhaul, and centralised processing. Additionally to the development of technology candidates across PHY, MAC, and the network layer, iJOIN will study the requirements, constraints, and implications for existing mobile networks, specifically 3GPP LTE-A.<br/>Results. iJOIN will design new network operation and management algorithms in the context of RANaaS, show their implications on 3GPP LTE, and evaluate the derived technologies with respect to four quantitative key objectives:<br/>1) system throughput2) energy-efficiency3) cost-efficiency4) utilisation-efficiency<br/>iJOIN will further impact<br/>1) the research community by identifying new challenges,2) business oppo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Taming, controlling and harnessing quantum complexity' to be submitted under Horizon Europe.

assistant: **Abstract**

Quantum processes hold tremendous potential for the development of novel technologies, as epitomized by the recent proliferation of commercially available quantum devices. To date, most research and innovation in the field has focused on spatial quantum effects – most prominently entanglement -- leaving quantum effects in time an as-of-yet untapped resource. Progress in understanding such effects has been hindered by the inherent complexity of quantum memory and the lack of an adequate conceptual framework. This, in turn, has prevented the development of tools to probe, predict and compress general quantum processes. This action aims to overcome these hurdles and answer the following fundamental questions: What kinds of quantum memory effects are physically possible? How can they be efficiently probed? How can predictive models for quantum processes be constructed? Answers to these questions will be obtained by combining a novel, fully-general approach to the dynamics of open quantum systems, with a proven, systematic construction of memory-minimal models of classical phenomena. The ensuing framework and tools will engender bounds on the strength and distribution of quantum memory,  enable the construction of predictive models for complex quantum processes, and render their characterization experimentally tractable. These crucial innovations will pave the way to a reconceptualization of quantum information processing that provides the means to harness the full potential of quantum processes, both in space and time. As a result, the outcomes of the action are expected to find long-term application in a wide array of fields, ranging from quantum information to complexity theory and bio-chemical processes.The research will be carried out at Trinity College Dublin, in the p