RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Geographical information systems for the archiving, exchange and manipulation of climate-related observations of Eurasian Arctic glaciers and ice caps' will create measurable scientific, societal and economic impact aligned with Fourth Framework.

assistant: **Impact**

RTD actions implementing ENRICH are part of accompanying measures of the Environment and Climate Programme, the Marine Science and Technology Programme and the International Cooperation Programme.%l CORDIS generally does not held information on accompanying measures of RTD programmes. Therefore for further details please contact: Ib Troen, European Commission, DGXII.D.I at ib.troen@ec.europa.eu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Understanding the host-environmental interactions across the lifespan determining lung function trajectories and COPD' in the context of a Horizon Europe call.

assistant: **Objectives**

Chronic Obstructive Pulmonary Disease (COPD) has been traditionally understood as a self-inflicted disease caused by tobacco smoking occurring in old individuals. Over the past few years, however, our group and others have proposed that the pathogenesis of COPD goes beyond smoking, and that there is a range of lung function trajectories through life (trajectome); some of them have roots in early life and can lead to COPD, cardiovascular and metabolic morbidity as well as premature death, while others are associated with healthy ageing. Here I propose that, detrimental gene (G) and environment (E) interactions occurring early in life (T) constitute a ‘first injury hit’ that alters the normal lung developmental program and modify the pace of normal lung aging by reducing the resilience of the lungs to future GxExT interactions. Accordingly, lifelong GxExT interactions determine the individual trajectome and, eventually, the occurrence of COPD and associated multimorbidity. PredictCOPD aims to identify the interactions and mechanisms that determine which individuals will develop COPD and multimorbidty at some point of their life.  The specific aims are: 1) to identify the lifelong environmental and host risk factors associated with the trajectome, COPD and multimorbidity, 2) to use a novel liquid biopsy method to identify biological factors driving the trajectome, COPD and multimorbidity; 3) to identify clinically relevant preventive and/or early therapeutic targets integrating the results from aims 1 and 2 with novel analytical approaches and 4) to validate findings both in vitro and in other available cohorts. The project will leverage from several available population and COPD patient studies with available clinical data and biological samples. The results of PredictCOP
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon Europe proposal on 'Spatial control of antigen-encoded supramolecular copolymers for robust T-cell activation against cancer'.

assistant: **Concept**

Nature uses a complex chemical language between cells and their environment to sustain life. T-cells, critical players of the immune system, constantly communicate and respond to environmental signals through cell-fate decisions to protect against pathogens. Their function in the immune system is of particular interest for cancer immunotherapy where their activation and expansion can be harnessed to kill cancer cells. Low affinity CD 8+ T-cells are attractive because of their memory to prolong the duration of therapy, but they are challenging to expand unlike their high affinity counterparts. In this proposal, I will explore the multimerization of tumor-associated antigens (TAAs) through the H2-Kb-OVA peptide complex on supramolecular polymer scaffolds to potentiate the activation and expansion of low-affinity CD8+ T-cells. I will develop monomers that undergo kinetically controlled supramolecular polymerization in water and explore the potential to prepare block copolymers by modulating the monomer design with respect to hydrogen bonding and hydrophobicity. Supramolecular block copolymers will be engineered with domains of distinct sizes at the nanoscale to enable control over the TAA presentation with respect to spacing and density. Additionally, the effect of modulating OVA peptide sequence Using a library of H2-Kb-OVA peptide complex outfitted supramolecular block copolymers with various peptide sequences I will map the potential for activation and expansion of low affinity CD 8+ T-cells. Importantly, the major aim of this proposal is to develop strategies to prepare supramolecular block copolymers in water with bioactive units to broaden the application space of this materials class in the biological field.


**Keywords:** Programmed Assembly, Living Supramolecular
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Prosperity through innovation and promotion of Sustainable Urban Mobility Plans'.

assistant: **Concept**

PROSPERITY will:1. Produce a culture shift in terms of environment for SUMPs in member states and in the organisational culture of transport planning in city authorities.2. Get ministries and national agencies to play a national leading role on SUMPs, as in many member states these are the organisations from which cities take their main direction; where ministries are already playing this role, to support and strengthen their approach.3. To provide mechanisms and tools for Ministries to take this lead role.4. Analyse clearly the problems of (lack of) take-up of SUMPs – to understand from cities themselves why they are not taken up and then to help cities to address these barriers.5. Extend the existing 25-county EU-SUMP-network with at least two more countries6. Get more cities to take up effective high quality SUMPs – through cities’ involvement in the project and indirectly through more cities hearing about SUMPs in their country.7. Ensure that these SUMPs contain and will lead to implementation of a broad range of innovative sustainable transport measures.8. Build cities’ capacity to develop and implement SUMPs that genuinely reflect the spirit of the EU SUMP Guidelines, rather than being mandatory documents to fulfil a requirement linked to major transport infrastructure.9. Deliver a measurable impact. The core concept of PROSPERITY is bringing ministries into the project, which will significantly enhance the visibility of the project at the national level and therefore increase numbers of cities active on SUMPs. Thus PROSPERITY will ensure that more cities commit to SUMPs that are in line with the EU SUMP Guidelines and that include a broad range of innovative measures. This will generate a high leverage factor, especially in regions and cities where take up is so
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Open Media Platform' (OMP).

assistant: **Innovation**

Supporting the next generation of content-rich networked services on mobile devices is presenting major technical challenges for Europe's semiconductor and Consumer Electronics industries. Unlike the standard PC architecture, these devices have huge variation in multimedia capability and must operate under widely varying network conditions. Software complexity growth on these devices is now outpacing software productivity improvements by a factor of 4 to 1. Limited by cost and time-to-market constraints, current practices result in client services that are statically defined and non-optimal within the context of operation. OpenMediaPlatform (OMP) aims to define an open service infrastructure for media-rich end-user de-vices that will address software productivity and optimal service delivery challenges. OMP innovatively combines two main streams of modern software engineering:<br/>1) Split compilation techniques that leverage component based SW engineering and provide binary portability (CLI standard) with no performance penalty;<br/>2) Standardized and open application programmers' interfaces (API) for advanced multimedia stacks that support resource management and context awareness at component level.<br/>Together, these two technologies will deliver a computing tools infrastructure and a media infrastructure to ensure optimal deployment of dynamically composed media services that scale with device and network capabilities. The OMP approach will be demonstrated using scalable video coding on two different platforms. The expected results are: <br/>1) An open-source GNU-based  static compiler for the generation of processor-independent CLI binaries with additional metadata for deployment-time component optimization,<br/>2) A CLI dynamic compiler and runtime system explo
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'ADVANCED CONTROL SOLUTIONS FOR WASTE WATER TREATMENT' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

Current procedures for the design of WWTP controllers are usually based on long and very expensive experimental studies. In this respect, the availability of WWTP simulation tools specific for control design would allow automation companies to establish and complement experimental procedures with enhanced procedures based on mathematical modeling and simulation. In addition, WWTP simulation software companies will find in automation companies a further potential market for selling their software products. Accordingly, the objective of this proposal is to design, implement and validate new simulation tools for practical control. Based on this WWTP virtualization, it will be feasible to manufacture enhanced and cost-effective control products, tested by simulation previous to their full-scale implementation.  To achieve these objectives, 3 software layers will be developed: “Mass”, “Instrumentation and actuation” & “Automation and control” layers. These developments will then be tested both at industrial and urban WWT scenarios. This work will be driven by 3 SME developers (M4W, software simulator, MSI, automation company, and NASKEO, environmental engineering) and 2 end user (SCAD, SME as industrial WWTP, and AGIPUZKOA as urban WWTP). They trust in the know-how of 3 key RTDs in this sector (CEIT, mathematic modeling and conventional control expert, UGENT, computer science expert, and INRA, advanced control and anaerobic digestion expert).  Due to this project, 3 exploitable results will be developed: (1) WWTP Software simulator, (2) Advanced controllers and (3) Enhanced treatment technologies. IPR has been divided among partners in order to maximize impact at European level. If this project is successful, the gathered knowledge will put Europe in pole position with respe
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Strengthening International Research on Geographical Indications: from research foundation to consistent policy', explaining its relevance to EU policy priorities under Sixth Framework.

assistant: **Impact**

Geographical indications (GIs) for agri-food products are a major asset of the European model of agriculture, acting not only as a tool for protecting consumers' interests and reinforcing confidence in high-quality typical products, but also as a legal and commercial basis for the development of rural areas, the preservation of cultural heritage as well as the promotion of SMEs. GIs are also a global issue, regulated in international law by the WTO and warranting increasing attention world-wide. However, no comprehensive analytic framework and data set is yet available to assess their effects. The objective of the Strengthening INternational Research on Geographical Indications (SINER-GI) proposal is to build and share a coherent scientific basis world-wide, regarding economic, legal, institutional and socio-cultural conditions of success of GIs, in order to support their legitimacy in the framework of WTO negotiations.The project approach builds on a review and typology of products bearing a GI under different institutional and market frames in former and acceding EU Member states and in Third countries. This database will lead to the formulation of a robust analytical framework and of internationally relevant monitoring indicators. The conceptual model will then be applied to in-depth analysis of selected case-studies in extra-EU countries compared to EU. Long-term scenarios will be assessed; policy recommendations will address improvements needed to maximise GIs contribution as a driver for rural development and consumers' confidence.We advocate an explicit international approach, since confining the scope of research to EU countries would eventually weaken the project capacity to provide a more comprehensive and internationally grounded scientific foundation of this
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Biomechanical Stimulation based on 4D Printed Magneto-Active Polymers'.

assistant: **Concept**

MAPs are polymer-based composites that respond to magnetic fields with large deformation or tuneable mechanical properties. I aim to apply heterogeneous 3D printed MAPs as modifiable substrates to support biological structures which can have their deformation state and stiffness controlled by the external application of magnetic stimuli. Such mechanical stimulation has an important role on biological structures leading to alterations in functional responses, morphological changes and activation of growth or healing processes. Current bottlenecks preventing progress in this field are a lack of: a) appropriate experimental methodologies to enable characterisation of the behaviour of these materials; b) fundamental theoretical underpinnings to support the design and application of these new materials. The first step is to undertake in depth characterisation and assessment of 4D printed MAPs to create a detailed understanding of the underlying physics controlling the interactions between the polymeric matrices and embedded magnetic particles during application of mechanical and/or magnetic loadings. I will then culture biological structures on the novel 4D printed MAPs to create a designed biostructure with specified and controllable responses to a given magnetic stimulus. These novel biostructures will be assessed using three applications: a) astrocyte cellular networks, b) neuronal circuits and c) astrocyte-neuronal networks. The evaluation of cellular damage, morphological and physiological alterations will validate the performance of the new biostructures and also contribute new understanding to the effects of deformation and stiffness gradients during glial scarring on physiological functions of central nervous system cells. The resulting deep understanding of magneto-
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Clinical proof of concept through a randomised phase II study: a combination of immunotherapy and stereotactic ablative radiotherapy as a curative treatment for limited metastatic lung cancer' (IMMUNOSABR) targeting Horizon 2020.

assistant: **Abstract**

IMMUNOSABR is geared towards opening up a new paradigm in treating metastatic cancer by obtaining clinical proof of concept for a novel bi-modal curative treatment strategy. High precision stereotactic ablative radiotherapy (SABR) is combined with immunotherapy to form a powerful synergistic anti-tumour strategy. The approach relies on the direct cytotoxic effect of SABR, the abscopal effect of radiation observed at distance from the irradiated metastatic site(s), and the effect of the tumour-specific immunocytokine L19-IL2 (watch our animation explaining the concept at https://youtu.be/6wDE6RkrikA).Palliative treatment is the current standard of care for patients with metastatic non small cell lung cancer (NSCLC), unless there is an actionable mutation. By using the concept of limited metastatic disease (≤10 sites, WHO 0-1: “oligo+”) we aim to develop a therapy with curative intent. IMMUNOSABR will gather evidence for the clinical efficacy of our bi-modal treatment strategy in a multicentre randomised phase II study (clinicaltrials.gov no. NCT02735850) in patients with limited metastatic NSCLC.  IMMUNOSABR is complemented by two strong biomarker work packages which focus on developing an ambitious personalised biomarker strategy, to identify patients who can benefit from the novel treatment strategy. This includes promising non-invasive imaging techniques and state-of-the-art immunological monitoring approaches on tumour tissue and blood. IMMUNOSABR will spur further development of L19-IL2 as a commercial drug and translate the bi-modal treatment strategy towards clinical implementation.


**Keywords:** Immunotherapy, SABR, L19-IL2, lung cancer, metastatic cancer
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Flexible and robust nervous system function from reconfiguring networks' to be submitted under Horizon 2020.

assistant: **Abstract**

It is now possible to monitor and manipulate neurons in live, awake animals, revealing how patterns of neural activity represent information and give rise to behaviour. Very recent experiments show that many circuits have physiology and connectivity that is highly variable and that changes continually, even when an animal’s behaviour and environment are stable. Existing theories of brain function assume that neural circuit parameters only change as required during learning and development. This paradigm cannot explain how consistent behaviour can emerge from circuits that continually reconfigure, nor what mechanisms might drive variability and continual change. Understanding this deep puzzle requires new theory and new ways to interpret experimental data. I will develop a theory of reconfiguring circuits by significantly generalizing my previous work that uses control theory to show how network activity can be maintained in spite of variability and continual turnover of crucial circuit components. We will analyse how biological plasticity mechanisms steer collective properties of neurons and circuits toward functional states without requiring individual parameters to be fixed, resulting in circuit models with consistent output but variable and mutable internal structures. In close collaboration with leading experimentalists we will challenge these modelling principles to account for new findings which reveal that navigation, sensory percepts and learned associations are underpinned by surprisingly dynamic, variable circuit connectivity and physiology. This will generate new, exciting questions that will drive experiments and theory together: how can known plasticity mechanisms generate reconfigurable neural representations? Do continually reconfiguring networks possess