RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Attaching and effacing escherichia coli infections : pathogenesis, host response and epidemiology.' (1998-2002) targeting Fifth Framework.

assistant: **Abstract**

Attaching-effacing Escherichia coli (AEEC) constitute a group of pathogenic bacteria common to human and animals. They include haemorrhagic E. coil (EHEC),the causative agent of human haemorrhagic colitis and haemolytic ureic syndrome (HUS), and pathogenic E. coli (EPEC), an agent of diarrhoea in infants and newborn animals. Public awareness on AEEC, and particularly on EHEC, has recently arisen from their implication in outbreaks of lethal HUS resulting from consumption of contaminated food products, in particular from bovine sources. The project brings together the competence of 12 European and associated research laboratories from the medical and veterinary sectors to understand the molecular,immunological and epidemiological basis for controlling zoometric EEC infections. The expected achievements of this project are to improve current strategies aimed at assessing and preventing the risk associated with AEEC.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Open rotor Engine WELDed parts  inspection using MINiaturizable NonDestructive Techniques' to be submitted under Seventh Framework.

assistant: **Abstract**

SAGE project, included in Clean Sky research project aims at demonstration of engines and technologies to reduce the fuel consumption and therefore reducing CO2 emissions in order to fulfill the European Aviation environmental objectives for 2020 of decrease 50% of CO2 emissions.WELDMINDT project is focused on giving solutions for the inspection of welded components with limited access in Open Rotor Engines. This will lead to a cost reduction in Open Rotor Engines manufacturing and maintenance by reducing the time of inspections, facilitating the market entry of this more effective and cleaner engines.Hence, indirectly the project results will have an important impact in environment, as well as the obvious industrial and technological impacts. Project’s main technical objectives are:- Integrate in a single system shearography, Infrared Thermography and Ultrasonic inspection- Use laser as a single excitation source for the inspection system- Advance in the knowledge of pseudo-real defects generation in advanced materials with different welding processes- Develop an automatic inspection system based on industrial robotics applications- Develop a FEM based model valid for fast piece simulation- Develop an “automatic” defect detection and sizing estimation softwareAs conclusion, directly or indirectly the following impact is expected:A) The combination of multiple NDT techniques added to the use of advanced signal processing will increase the defect detection rate and size precision more than 20%B)Change the aero-engine inspection time concept: from minutes-hours (or even days in maintenance) to secondsC)Reduce simulation time more than 90% maintaining the precisionD)By means of flexible fibres and other techniques as mirrors gain access/vision to currently inaccessible par
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Experimental autoimmune diabetes mellitus: pathogenesis and treatment' in the context of a Fifth Framework call.

assistant: **Objectives**

To use the NOD mouse strain to investigate the pathogenic mechanisms of autoimmune diabetes mellitus, to identify disease genes and to design and optimise novel therapeutic protocols that prevent irreversible destruction of insulin-producing cells and induce long-lasting self-tolerance.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Deciphering the role of PI(4,5)P2 and its modulators PPK-1 and CSNK-1 in nematode asymmetric division' will create measurable scientific, societal and economic impact aligned with Horizon 2020.

assistant: **Impact**

The first embryonic division of Caenorhabditis elegans is a powerful system to dissect the mechanisms governing asymmetric division, which relies on PAR-proteins for cell polarity and on dynein-dependant forces for centrosome and spindle positioning. In contrast to the extensive knowledge regarding proteins regulating asymmetric division, the contribution of plasma membrane tension, as well as of PIP2 and its modulators PPK-1 and CSNK-1 is poorly understood. I propose to decipher these questions as follows:1) PIP2 is enriched in the embryo anterior in microdomains of the plasma membrane. I will test the contribution of PPK-1, the only kinase from the proteome converting PIP into PIP2 in formation of PIP2 microdomains distribution, cell polarity and pulling force. This will be achieved through ppk-1(RNAi) as well as two complementary optogenetic approaches to obtain acute spatiotemporal inactivation of PIP2.2) I will decipher how the casein kinase CSNK-1 interacts with and phosphorylates PPK-1, thereby presumably regulating PIP2 microdomain distribution and function, as well as identify and characterize up to three CSNK-1 phospho-substrates with. 3) I will test whether PIP2 undergoes phase separation driven by a decrease in plasma membrane tension, and, if so, investigate the consequences on asymmetric division. Moreover, I will study the relationship between membrane tension and cortex contractility.4) I will analyze asymmetric cell division in the one-cell Pristiochus pacificus embryo I will then use the knowledge acquired in C. elegans to conduct related experiments in P. pacificus, thus investigating potential conserved and divergent themes governing asymmetric division across nematode evolution.Overall, these experiments will shed critical light on the poorly unders
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Absolute Spin Dynamics in Quantum Materials'.

assistant: **Concept**

One of the greatest challenges in exploiting the electron spin for information processing is that it is not a conserved quantity like the electron charge. In addition, spin lifetimes are rather short and correspondingly coherence is quickly lost. This challenge culminates in the coherent manipulation and detection of information from a single spin. Except in a few special systems, so far, single spins cannot be manipulated coherently on the atomic scale, while spin coherence times can only be measured on spin ensembles. A new concept is needed for coherence measurements on arbitrary single spins. Here, the principal investigator (PI) will combine a novel time- and spin-resolved low-temperature scanning tunneling microscope (STM) with the concept of pulsed electron paramagnetic resonance. With this unique and innovative setup, he will be able to address long-standing problems, such as relaxation and coherence times of arbitrary single spin systems on the atomic scale as well as individual spin interactions with the immediate surroundings. Spin readout will be realized through the detection of the absolute spin polarization in the tunneling current by a superconducting tip based on the Meservey-Tedrow-Fulde effect, which the PI has recently demonstrated for the first time in STM. For the coherent excitation, a specially designed pulsed GHz light source will be implemented. The goal is to better understand the spin dynamics and coherence times of single spin systems as well as the spin interactions involved in the decay mechanisms. This will have direct impact on the feasibility of quantum spin information processing with single spin systems on different decoupling surfaces and their scalability at the atomic level. A successful demonstration will enhance the detection lim
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Foster the Access to CRAFT measures for Information Technology' will create measurable scientific, societal and economic impact aligned with Fifth Framework.

assistant: **Impact**

The FACIT objective is to effectively stimulate SMEs to submit CRAFT proposals under the FP5 IST programme. The target is end-user-SMEs in which the use of ICT improves their operative process and their market position. Four trade sectors have been selected (tourism, aerospace, automotive, digital publishing). In order to create their awareness of ICT opportunities, SME's technical needs will be collected and analysed through questionnaires, workshops, and on-site technical needs of 300 SMEs. The main outputs will be a better knowledge of the end-users ICT needs, the SMEs profile likely to be interested in submitting IST CRAFT proposals, and the preparation of at least 20 projects proposals, including 10 CRAFT.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Seventh Framework proposal on 'Knowledge, Awareness and Prediction of Man, Machine, Material and Method in Manufacturing'.

assistant: **Concept**

Manufacturing is the driving force of Europe's economy, providing over €6,553 billion in GDP. However against a background of climate change legislation, volatile energy prices and increased environmental awareness, modern manufacturing must encompass a focus on eco-efficiency. Given the current economic situation, this must be achieved without the need for large capital expenditure. Adding information technology to an already existing production facility is a cost-effective investment. The KAP project will deliver energy management standards and a technology framework for next generation, sustainable manufacturing. KAP stands for Knowledge of past performance, combined with Awareness of the present state, which together can support Prediction of future outcomes. This philosophy forms the basis of a framework that will enable every existing resource to be used as efficiently as possible through the effective co-ordination of man, machine, material and method. To achieve this goal the project will define a range of sustainable manufacturing standards. Measurements will be gathered through a factory-wide network of sensors. Complex Event Processing (CEP) and data stream analysis will compute on-the-fly production performance indicators (PPIs) for real-time monitoring. Data mining in combination with OLAP will support problem diagnosis and resolution. Computational learning techniques will create a self-improving system for operational control. The inclusion of energy management makes the interpretation of system data an even greater challenge. Perceptually efficient visualisations will communicate PPI's to decision makers in a format that will reduce cognitive workload and improve situation awareness. A well-balanced consortium of research centres, academic and industry p
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Expanding the genetic etiological and diagnostic spectrum of monogenic diabetes mellitus' (DecodeDiabetes) targeting Horizon 2020.

assistant: **Abstract**

Whole genome sequencing is quickly becoming a routine clinical instrument. However, our ability to decipher DNA variants is still largely limited to protein-coding exons, which comprise 1% of the genome. Most known Mendelian mutations are in exons, yet genetic testing still fails to show causal coding mutations in more than 50% of well-characterized Mendelian disorders. This defines a pressing need to interpret noncoding genome sequences, and to establish the role of noncoding mutations in Mendelian disease.A recent case study harnessed whole genome sequencing, epigenomics, and functional genomics to show that mutations in an enhancer cause most cases of neonatal diabetes due to pancreas agenesis. This example raises major questions: (i) what is the overall impact of penetrant regulatory mutations in human diabetes? (ii) do regulatory mutations cause distinct forms of diabetes? (iii) more generally, can we develop a strategy to systematically tackle regulatory variation in Mendelian disease?The current project will address these questions with unique resources. First, we have created epigenomic and functional perturbation resources to interpret the regulatory genome in embryonic pancreas and adult pancreatic islets. Second, we have collected an unprecedented international cohort of patients with a phenotype consistent with monogenic diabetes, yet lacking mutations in known gene culprits after genetic testing, and therefore with increased likelihood of harboring noncoding mutations. Third, we have developed a prototype platform to sequence regulatory mutations in a large number of patients.These resources will be combined with innovative strategies to uncover causal enhancer mutations underlying Mendelian diabetes. If successful, this project will expand the diagnostic s
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Recyclable Metal-free Photocatalysts for Synthetic Chemistry based on Covalent Organic Frameworks' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

The discovery of smart and highly efficient catalysts for solar energy conversion and green fuel production is a global scientific challenge due to increasing energy demand and related environmental consequences. Synthetic photocatalysis is highly promising, but employs to date expensive and/or toxic metals, such as Pt, Au, Ru, Cd, Ag, and Ir. This hampers the development of large-scale and introduces environmental issues. The aim of this proposal is to develop stable, recyclable and metal-free heterogeneous photocatalysts for the Diels-Alder (D–A) reaction. D–A reactions are one of the most powerful synthetic protocols for the synthesis of unsaturated six-membered rings, yet to be well established for the industry. Herein, we selected porous organic polymers, namely Covalent Organic Frameworks (COFs) and Covalent Triazine Frameworks (CTFs), because they allow synergistic utilization of their skeleton and pores. Due to their high porosity and uniform pores, they allow for confined space synergies and easy mass transport. The pi-species in these catalysts are highly photo-catalytically active. These metal-free insoluble-polymer-catalysts are expected to show high thermal and chemical stability. Therefore, these catalysts can be easily separated out from the reaction mixture and re-activated for cycle use. Furthermore, we will use these catalysts in a continuous-flow reactor, which could open up a new avenue for catalyst industry.


**Keywords:** Metal-free catalyst,  Heterogeneous,  Recyclable,  Photocatalysis,  Diels-Alder reactions
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Influence of the Mediterranean Outflow on the Atlantic Ocean Climate: the role of local scale processes' (INMEDIATO).

assistant: **Concept**

It is widely accepted that the Mediterranean Outflow (MO) has influence on deep water production in the North Atlantic (NA), and therefore on NA climate, but the extent of that influence remains controversial and closely linked to the dispute about preferred MO pathways to the northern seas: a direct advective pathway (strong influence) or an indirect one through mixing with NA Current waters (weak). The MO spreading pathways are quite well established in the vicinity of the Iberian peninsula from hydrographic data, unfortunately further north it is hard to estimate from observations what the direct/indirect contribution of MO to the warm saline inflow into the northern seas is. Climate models addressing this issue support the indirect hypothesis, however they are unable to resolve adequately the Strait of Gibraltar (SoG) and the Gulf of Cadiz (GoC) – key areas where local-scale processes may impact on MO properties and spreading – and fail to represent adequately the MO signatures in the NA as compared to observations, with higher salinities, mainly southward from the SoG and an exaggerated MO diffusive spreading pattern. Regional/process models with higher resolution present the disadvantage of prescribing open boundary conditions, short time-scale runs and the lack of feedback with larger scale circulation. Considering that tidally-driven processes might be relevant at the SoG and GoC, where the width of the MO plume is few tenths km, our goal is to investigate the effect of MO on the NA climate establishing: 1) how local-scale processes at SoG and GoC affect the MO properties and spreading; 2) the way the MO accesses the northern seas; 3) the relevance of that local-scale processes for the NA climate. We propose an integral approach allowing to resolve the local-sca
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'DownScaling CLImate imPACTs and decarbonisation pathways in EU islands, and enhancing socioeconomic and non-market evaluation of Climate Change for Europe, for 2050 and beyond.' (SOCLIMPACT).

assistant: **Innovation**

The warming of the climate system is unequivocal and continued emission of greenhouse gases will cause further warming and changes. Islands are particularly vulnerable to Climate Change (CC) consequences but the coarse spatial resolution of available projections makes it difficult to derive valid statements for islands. Moreover, science-based information about the economic impacts of CC in marine and maritime sectors is scarce, and current economic models lack of solid non-market assesment. Policy makers must have accurate information about likely impact chains and about the costs and benefits of possible strategies to implement efficient measures. SOCLIMPACT aims at modelling downscaled CC effects and their socioeconomic impacts in European islands for 2030–2100, in the context of the EU Blue Economy sectors, and assess corresponding decarbonisation and adaptation pathways, complementing current available projections for Europe, and nourishing actual economic models with non-market assessment, by:• Developing a thorough understanding on how CC will impact the EU islands located in different regions of the world.• Contributing to the improvement of the economic valuation of climate impacts by adopting revealed and stated preference methods.• Increasing the effectiveness of the economic modelling of climate impact chains, through the implementation of an integrated methodological framework (GINFORS, GEM-E3 and non-market indicators).• Facilitating climate-related policy decision making for Blue Growth, by ranking and mapping the more appropriate mitigation and adaptation strategies.• Delivering accurate information to policy makers, practitioners and other relevant stakeholders.SOCLIMPACT addresses completely this Work Programme providing advances in the economic valuat