RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the specific objectives and expected outcomes for 'Inferring hominin population history through space and time using introgressed haplotypes' in the context of a Horizon Europe call.

assistant: **Objectives**

In the last decade, ancient DNA studies have increased their throughput from single samples to thousands of genomes published every year, giving us unprecedented data about human genetic history. However, tools and methods that efficiently use this wealth of data are sorely lacking, especially because DNA extracted from fossils is often scarce and contaminated. In this project, I develop population genetic theory and bioinformatic methods that use ancient DNA to refine estimates of when and where archaic and modern humans interbred, to characterize the historical, biological and functional consequences of this gene flow, and to learn about the differences between modern humans, Neandertals, and Denisovans. The first aim of this project is to develop a robust and general genotype-likelihood approach for local ancestry inference that allows efficient use of contaminated, low-coverage data, and to establish approximate haplotype-based methods for inferring introgression tracts.The second aim of the project is to develop the necessary population genetic theory and statistical methods to translate the inferred haplotypes into biological insights. The proposed theoretical, numerical and simulation-based approaches will link the inferred introgression patterns with the underlying population genetic processes.The final aim is to apply these novel tools to study where and when gene flow between Neandertals, Denisovans, and modern humans occurred. I also aim to identify introgressed haplotypes that are a target of natural selection and to quantify the relative importance of positive, negative, and balancing selection on Neandertal and Denisovan gene flow. As a result, this work will expand the tool set available for the analysis of ancient DNA, reveal the precise history of the i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Chemical biology of intracellular cholesterol transport' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Cholesterol transport proteins (CTPs) regulate cellular metabolism, hormone biosynthesis, and organelle contacts, with profound consequences for human health and disease. Despite this, almost no small molecule CTP modulators have been reported, and no methods for determining selectivity across the broader protein class exist. Selective CTP inhibition is conceptually challenging as all CTPs are structurally similar and bind cholesterol. Furthermore, due to redundancy among several CTPs, deciphering the biological roles of their individual cholesterol transport activity has been difficult. ChemBioChol aims to unravel the functions of individual CTPs by developing selective small molecule modulators. Based on seminal work from my lab, I propose employing a sterol-inspired compound design strategy consisting of a primary sterol fragment as “anchor” for CTP binding, fused to secondary natural product fragments to engineer selectivity of the compounds for individual CTPs. My group will develop bio-physical and -chemical tools to determine lipid selectivity of CTPs and optimise selective molecules against them. Preliminary data on the Aster CTP family provides a proof-of-principle that selective and potent chemical tools are attainable, and that the concept is applicable to further CTP families. To determine cellular selectivity of CTP inhibitors against all cholesterol-binding proteins, I will also develop a mass spectrometry-based chemical proteomic approach with a universal cholesterol probe. Optimised CTP inhibitors will be used to determine how CTPs mediate lipid metabolism and trafficking, and their effect on sterol-mediated processes including mTOR signaling and autophagy, with potential applications in neurodegenerative disorders and cancer. A general approach for sele
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Information society technologies to open knowledge. Russia' (2002-2006).

assistant: **Concept**

The main objective of ISTOK.Ru is to identify constituencies and potentialities for deeper strategic cooperation with Russia, a country that the bi-cultural ISTOK.Ru' team considers as strategic partner for a successful multi-dimensional project. The ISTOK.Ru project intends to screen and analyze common needs and opportunities by the rank mapping of all Russian ICT technologies relevant to co-operation and the cross-comparison with European ICT taxonomy. A building of a consultancy network opened to Scientifics, researchers, experts, industrials, and policy makers will support a constructive dialogue with ICT actors both in Russia and in the European Union, that will be a source" of new ideas, concepts and technologies allowing to maximize the knowledge in the field of ICT collaboration and to concretize the basis for the formulation of a global EU strategy for further initiative.The proposed work plan condensed in 3 Work Packages ensures strict project monitoring and guarantees its usefulness by the development of an Internet-based open consultancy community of 2,000 relevant references, involving experts in ICT domain in the process of technologies' screening , and the organization of five awareness raising events in Europe and Russia in order to increase the visibility of the project's results and encourage additional funding to ensure the sustainability of the project. Taking full advantage of current trends in research cooperation thinking, ISTOK.Ru is the impetus for future European international cooperation.ISTOK.Ru is thus a flexible response to unforeseen cooperation policy needs and a great opportunity to build a bridge between Russian and European ICT research to match common challenges and resources. It is a strong support tool coupled with developing polici
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Semiconducting Nanowire Platform for Autonomous Sensors' (SiNAPS).

assistant: **Concept**

The aim of the SiNAPS project is to develop standalone dust"-sized chemical sensing platforms that harvest energy from ambient electromagnetic radiation (light) and will enable miniaturisation below the current mm^3 barrier. Current solutions in nanoelectronics are enabled by new materials at the nanoscale. It is proposed to use high-density semiconductor nanowire arrays, such as Si and Ge, as efficient photovoltaic units and low-power chemical sensing elements on small volume modules to be integrated, via 3D system in a chip, in a miniaturised platform that transmits the acquired information wirelessly for further processing. To demonstrate the proof-of-concept without committing huge resources in optimization the SiNAPS project has set a pragmatic but ambitious, miniaturisation target ~10^8 µm^3, beyond the state-of-the-art. With further development of the energy harvesting and sensing technology, 10^6 µm^3 and below can be possible.SiNAPS brings together a consortium to address the two topics of the ICT-Proactive call, namely: (a) fundamentals of ambient energy harvesting at the nanoscale and (b) development of self powered autonomous sensor devices, with target dimensions of 1 mm^3. These topics are of great interest in the areas of energy supply, energy use in ICT, smart(er) buildings, medical diagnostics, e-health and integrated smart systems.SiNAPS involves the development of the capacity of nanowires for use as a nanoscale energy harvester and a (bio-)chemical sensor for the prototype biotin-streptavidin system via fundamental studies. Miniaturised CMOS electronics will be developed for efficient power management and sensor interface. Existing IP for wireless communication will be used to avoid costly development. The integrated modules will be used to demonstra
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'Decision-making and prefrontal executive function' will create measurable scientific, societal and economic impact aligned with Seventh Framework.

assistant: **Impact**

The prefrontal cortex (PFC) subserves decision-making and executive control, i.e. the ability to make decisions and to regulate behavior according to external events, mental models of situations, internal drives and subjective preferences. Our overall aim is to understand the functional architecture of the human PFC and computational mechanisms of PFC function. The PFC function is known to operate along three major dimensions, namely the affective, motivational and cognitive control of action subserved by the orbital, medial and lateral sectors of the PFC, respectively. In this project, our specific objectives are to solve the following three open issues of critical theoretical significance: (1) the functional organization of motivational control in the medial prefrontal cortex; (2) the mechanisms that enables the PFC to control the learning of representational sets required for cognitive control; (3) the functional interactions between the medial and lateral prefrontal cortex, i.e. the integration of motivational and cognitive control into a unitary decision-making and control system. We will address these theoretically and methodologically challenging issues by elaborating computational models that integrate learning and control mechanisms, and in relation to these models, by conducting functional magnetic resonance imaging experiments in healthy humans. The project is expected to significantly improve our knowledge of the human PFC function. This basic project has potential major implications especially in medicine, because alterations of the prefrontal function is observed in aging and most neuropsychiatric diseases, as well as in technology for developing artificial and robotics intelligence with human-like adaptive reasoning and decision-making abilities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'BovReg - Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle' to be submitted under Horizon 2020.

assistant: **Abstract**

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle popu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Fluorine substituted High Capacity Hydrides for Hydrogen Storage at low working temperatures' demonstrating excellence, impact and implementation quality for a Seventh Framework call.

assistant: **Abstract**

At present there is no solid state hydrogen storage material available fulfilling all requirements for practical use in mobile applications. These are 1. high storage density, 2. temperatures and heats of operation compatible with PEM fuel cells, 3. high hydrogen loading and unloading speeds in the range of a few minutes and 4. low production costs. FlyHy focuses especially on the first three points while using commercially upscalable materials preparation processes. High hydrogen capacity materials like alane or borohydrides as well as so called Reactive Hydride Composites (mixtures of borohydrides with selected other hydrides), nowadays suffering from too high or too low reaction temperatures and heats, shall be modified by substituting halogens for part of the hydrogen or hydrogen containing complexes. The project partners IFE, GKSS and AU have shown that by this approach novel mixed hydrido-halogenide compounds can be prepared. Fluorine substituted Sodium Alanate exhibited drastically increased desorption pressures at the same reaction temperature or lowered reaction temperatures at the same pressure resp. Targets of the FlyHy project are (i) to exploit these findings on materials destabilisation and stabilisation resp. by halogen substitution for alane, borohydrides and Reactive Hydride Composites , in order to achieve a breakthrough in the thermodynamic properties of these materials exhibiting the highest hydrogen capacities known at present, (ii) to obtain an in depth scientific understanding of the sorption properties of the substituted materials by extended structural and thermodynamical characterisation and modelling, for materials optimisation, (iii) determine tank relevant materials properties like e.g. densification behaviour and heat conductivity, and, if
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Understanding individual heterogeneity in ageing from stochastic dynamics of sigma factor regulatory network in bacteria' (ASNet) targeting Horizon Europe.

assistant: **Abstract**

Ageing is controlled at the molecular level via genetic and metabolic pathways. Ageing rates and patterns vary substantially even with fixed genetics and environment. However, molecular mechanisms of ageing generating individual heterogeneity are poorly understood. Stochastic dynamics of gene expression can be a main source of the variation in cellular damage dynamics leading to individual heterogeneity in ageing. The sigma factor regulatory networks constitute the core part of the bacterial gene expression networks and therefore play important role in deciding the fate of bacterial cells. In this project, I focus on exploring the role and interplays of four major sigma factors rpoD, rpoS, rpoH, rpoN in individual E. coli cells. I plan to (1) obtain these sigma factors’ expression dynamics and the demographic fates at individual E. coli cells in microfluidic platforms under fluorescent microscope; (2) process and analyze big image data in an automated manner; (3) develop mathematical models to interpret expression and demographic signals for damage and ageing. I will combine the knowledge and methods from the disciplines of molecular biology, genetics, fluorescent microscopy and microfluidics, machine learning, population and evolutionary dynamics and mathematical modelling to shed light on the link from stochastic expression dynamics in sigma factor regulatory network towards individual variations observed in ageing fates.


**Keywords:** bacterial ageing,  individual heterogeneity, biodemography, evolutionary demography, theoretical biology, mathematical biology, gene networks, sigma factor regulatory network, bacteria
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'Concept and Approach' section for a Horizon 2020 proposal on 'Novel Nanoengineered Optoelectronic Biointerfaces'.

assistant: **Concept**

Interfacing with neural tissues is an important scientific goal to understand cellular processes and to combat nervous-system related diseases. Nanotechnology has a significant potential for the development of new neural interfaces. The atomic-level design and control of the nanostructures for neural interfacing can revolutionize the junction between neurons and nanomaterials. In this project, we propose a totally new approach for understanding fundamental requirements and from this knowledge designing customised nanomaterials with optimised characteristics. These will be used to develop and demonstrate unconventional neural interfaces that are ultimately designed, controlled and constructed at the nanoscale. Hence, the key objectives of this proposal are: (1) to use quantum mechanics in a new way to control and explore the neural photostimulation mechanism, (2) to explore, design and synthesize new biocompatible colloidal nanocrystals for neural photostimulation, to overcome the limitations in terms of toxic material contents (e.g., cadmium, lead, mercury, etc.), (3) to demonstrate novel biocompatible neural interfaces with exciton and quantum funnels, and plasmonic nanostructures for enhanced spectral sensitivity and dynamic range. This new approach from quantum mechanical design to nanocrystal assembly will enable exploring, tuning and controlling the underlying physical mechanisms of neural photostimulation. Furthermore, the biocompatible nanomaterials will result in a more reliable nanobiojunction. The funnel and plasmon structures will lead to unprecedented spectral sensitivities and dynamic ranges that are far beyond the state-of-the-art optoelectronic interfaces. The project is therefore expected to have high impact and may herald a new paradigm in neural interf
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Analysis of the Artistic Exchanges in the Medieval Mediterranean between 12th and 15th Centuries through the Geographical Information Systems (GIS): A Critical Review of Centre and Peripheries' (GIS).

assistant: **Innovation**

The aim of this research project is to evaluate the artistic exchanges in the Mediterranean during the late Middle Ages through the Geographical Information Systems (GIS). The start point is the selection of certain elements of the Islamic art, developed by the Almoravids in the 12th century. It is assumed that Almoravid arts and architecture were not isolated and can be related to other Mediterranean artistic manifestations due to commercial, political and cultural relations. In this context, the objectives of the project are: to measure the presence of the pre-selected elements in the main artistic manifestations of the Islamic and Christian Mediterranean countries in the late Middle Ages, to apply the new method based on the GIS, through the creation of three databases for studying the exchanges between the main Mediterranean artistic manifestations and Almoravid art, to assess the relation of religion and power with the artistic productions of the Islamic countries in the Mediterranean frame and to review the concepts of centre and peripheries regarding the artistic production in the Mediterranean context.To achieve the objectives the fellow will extract the study data from the historiography, Arab and Latin written sources related to this period, and the artistic funds of the main museum collections with medieval Mediterranean pieces. The results will be included in a database, a blog and several publications, which will be available for the scientific community and the general public.The importance of this project lies in the revision of concepts, the improvement of the knowledge of societies that lived simultaneously in a given territory through the study of their culture and thought, and the introduction of an innovative method for the Art History research, base