RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Vaccines against helminth infections' (PARAVAC).

assistant: **Concept**

Livestock production efficiency is impaired by helminth infection which is ubiquitous in cattle, sheep and goats world-wide. It causes severely debilitating gastro-intestinal, respiratory and hepatic disorders, dependent on the infecting species. The treatment and prevention of helminth parasitism in livestock continues to rely almost exclusively on the use of anthelmintic drugs,  an approach threatened by the global emergence of anthelmintic resistance. An alternative approach is vaccination.Members of the present consortium (from the EU and Switzerland, North and South America, North and South Africa, Australia, 2 SMEs and 1 major animal health company)  have developed prototype vaccines with the predicted required efficacy to control major gastro-intestinal nematode infections of livestock, notably Ostertagia ostertagi in cattle and Haemonchus contortus in sheep, the liver fluke Fasciola hepatica in sheep and cattle with leading positions in subunit vaccine development against Cooperia onchophora, Dictyocaulus viviparus in cattle and the tapeworm Echinococcus granulosus in dogs.This proposal aims to deliver at least one prototype vaccine to the point of uptake by the commercial sector or through government/philanthropic agencies and this will be addressed by1)Developing effective native or synthetic vaccines, the latter using novel, molecular expression systems.2)Defining the protective immune responses induced by these vaccines to order to optimise the structure of the antigens and the method of their delivery.3)Defining vaccine efficacy with trials in both housed and grazing livestock4)Providing a platform for training and knowledge exchange which includes participation in training programmes, short exchanges of staff, workshops,and web site provision.5)Interacting
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals' to be submitted under Horizon 2020.

assistant: **Abstract**

The objective of RAMan spectroscopy for tracking Exosome based delivery of Nutraceuticals (RAMEN), is to design nanometer sized intestine targeted iron supplement delivery vehicles, based on milk derived exosomes to efficiently address anaemia prevalent among 614 million women and 200 million children worldwide. Specifically, enterocytes, which are cells responsible for iron absorption (receptor mediated endocytosis) and conversion to usable forms in the body, will be targeted, and the exosomes will be functionalised with cell penetrating peptides to circumvent endocytosis, facilitating direct delivery of the iron supplement to the cytosol. The direct delivery we hypothesise will help improve iron supplementation at low doses with minimum side effects and in cases with reduced expression of uptake receptors. This uptake by enterocytes will be tracked using Raman spectroscopy, a label-free live cell technique, observing the molecular signatures of exosomes and the changes in the signature of iron supplements, after delivery and conversion to usable forms in cells and animal free in vitro intestine model. This project will be implemented by Dr Sounderya Nagarajan (ER), who has expertise in functional nanoparticles for in vitro targeted bioimaging, under the supervision of Prof. Hugh J. Byrne (FOCAS Research Institute), who is an expert in Raman spectroscopy for cytological studies and drug delivery analyses in collaboration with Prof. David Brayden (University College Dublin) who is an expert in industry standard in vitro intestinal models. The fellowship will expand the skills of the ER in designing cell specific nanomedical/supplement delivery and label free monitoring techniques and her understanding of IP protection and project management, towards establishing herself
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Combined application of targeted therapy and immunotherapy in chronic myeloid leukaemia' (2007-2013).

assistant: **Innovation**

Chronic myeloid leukaemia (CML) is a disease of the haemopoietic stem cell, arising from a translocation t(9;22)(q34;q11). This translocation gives rise to a Philadelphia chromosome together with a BCR-ABL fusion gene that codes for a fusion protein with greatly enhanced tyrosine kinase activity. CML is a paradigm for the use of immunotherapy as well as being a model disease for the use of molecularly targeted therapies (tyrosine kinase inhibitors-TKI) in malignant disease. In patients with newly diagnosed chronic-phase CML, treatment with TKI results in a high rate of durable complete cytogenetic responses (CcyR), but 15% of patients never achieve a CCyR and a further 15-20% of patients achieve a CCyR but subsequently lose it. Moreover in the majority of patients who do respond well, BCR-ABL transcripts can still be detected in the blood and marrow for many years. These and others lines of evidence suggest that leukaemia stem cells persist in all or almost all patients and could pose a  risk for relapse after many years of apparently successful treatment. In this study we propose to exploit this status of ‘minimal residual disease’ achieved with TKI by using a multi-epitope vaccine approach to eliminate all persisting leukaemia. Furthermore, we will investigate if the addition of  immunomodulatory agents such as interferon-alpha will further enhance this vaccine-induced immune effect.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon 2020 proposal for the project 'SOCP-Tailored Real-time Algorithm for Trajectory Onboard Synthesis'.

assistant: **Objectives**

This research aims to develop a unified framework to compute in real-time optimal guidance solutions by merging two of the most promising technologies arisen over the last years, that is, pseudospectral optimal control, and convex optimization. The rationale for this choice can be found in the following motivations:1. The former theory has very interesting properties, such as the quasi-exponential convergence to the true optimal solutions, and was already used to re-orient the International Space Station in 2006, leading to a save of about 1,000,000$ in terms of required propellant with respect to the previous methods.2. Convex-optimization provides the technology to solve optimal control problems in real-time, a key feature for the future space systems, and computes the global optimum.3. The two technologies are complementary as each method’s drawbacks are counterbalanced by the other method’s strengths, and their unification will yield an improvement of performance since the solutions will be optimal, in the sense of maximizing or minimizing a given criterion, while nowadays only sub-optimal schemes are available.4. The research outcome will find applications in several industrial fields, leading to beneficial effects outside the space engineering field as well.The hybrid approach will consist in transcribing the original optimal control problem by using pseoudospectral transcription, that is, by adopting differential, integral, and discretization operators coming from pseudospectral methods. The resulting discrete problem will be then posed in convex form, suitable for real-time applications.The research will focus on the theoretical and algorithmic part, to be developed at the San Diego State University with Prof. Ping Lu during the first two years of program, while
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Welding of airframes by friction stir (WAFS)' (WAFS) targeting Fifth Framework.

assistant: **Abstract**

Airframes are made by mechanically fastening subcomponents together or by integrally NC machining them from solid material. Mechanical fastening suffers from a weight penalty, difficulty of automation, requirement for sealants and corrosion problems. NC machining is a wasteful process in terms of time, energy and raw material. Welding can provide cost savings of up to 30% and weight savings of up to 10%. FSW has great potential for manufacturing airframes. Therefore the objective of the WAFS project is to, Advance the state of the art of Friction stir Welding (FSW) to enable the widespread adoption of the technology to primary structures in airframes. Project outputs and areas of innovation will be FSW tool designs and process parameters; new techniques for improvement of properties of joints made with FSW; repair procedures FSW; design data and rules in airframe applications and modelling tools for FSW.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the concept and methodology overview for 'Multi-wavelength observations of gamma-ray bursts and instrument developement' under Sixth Framework.

assistant: **Concept**

Gamma-Ray Bursts (GRBs) are extraordinary sources. A typical GRB occurs in a star-forming galaxy at a redshift ~1. There is proof that at least some GRBs are caused by the collapse of a massive star when the supply of nuclear fuel has been exhausted. The merger of compact objects may also produce GRBs. In either case the progenitor produces a black hole and an accretion disk. In this configuration the energy can be extracted and accelerates a fireball of matter to ultra-relativistic velocities. Photons are produce via synchrotron radiation or inverse Compton emission. In our frame the radiation is primarily in gamma-rays and lasts for about 30 seconds and has an isotropic energy of ~10^53 ergs. There is evidence that the radiation is strongly beamed into a n opening angle of a few degrees, which reduces the total energy. The expanding shells interact with the medium to produce external shocks, which give rise to long-lived afterglow in the X-ray, optical, infrared and radio bands, which may be detected for d ays to months after the GRB. The aim of this proposal is to provide training for the applicant by carrying out leading edge research in the exciting, cutting edge field of GRBs in the Gamma-ray Group at MPE. There are three main training and research aims. The first aspect is to work on GRB spectra, polarization on active missions particularly INTEGRAL. MPE has extensive involvement on the SPI instrument on INTEGRAL. The group also has extensive experience in gamma-ray astronomy and instrumentation. The sec ond aspect is to be involved in the GLAST Burst Monitor. The host institutes is a major contributor to this instrument and are leading experts. The GBM will be launched on the GLAST mission. The final aspect involves the GROND camera, a seven-colour camera due to
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Complex structure and dynamics of collective motion', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

Collective behaviour is a widespread phenomenon in nature and technology making it a very important subject to study in various contexts. The main goal we intend to achieve in our multidisciplinary research is the identification and documentation of new unifying principles describing the essential aspects of collective motion, being one of the most relevant and spectacular manifestations of collective behaviour. We shall carry out novel type of experiments, design models that are both simple and realistic enough to reproduce the observations and develop concepts for a better interpretation of the complexity of systems consisting of many organisms and such non-living objects as interacting robots. We plan to study systems ranging from cultures of migrating tissue cells through flocks of birds to collectively moving devices. The interrelation of these systems will be considered in order to deepen the understanding of the main patterns of group motion in both living and non-living systems by learning about the similar phenomena in the two domains of nature.  Thus, we plan to understand the essential ingredients of flocking of birds by building collectively moving unmanned aerial vehicles while, in turn, high resolution spatiotemporal GPS data of pigeon flocks will be used to make helpful conclusions for the best designs for swarms of robots. In particular, we shall construct and build a set of vehicles that will be capable, for the first time, to exhibit flocking behaviour in the three-dimensional space. The methods we shall adopt will range from approaches used in statistical physics and network theory to various new techniques in cell biology and collective robotics. All this will be based on numerous prior results (both ours and others) published in leading interdiscipl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Uncovering the role of the m6A epitranscriptome in Myotonic Dystrophy Type 1 (DM1)'.

assistant: **Objectives**

RNA metabolism is regulated by multiple post-transcriptional layers, primarily orchestrated by RNA-binding proteins (RBPs). When disrupted these processes can lead to diseases like myotonic dystrophy type 1 (DM1), a rare inherited disorder affecting skeletal muscle. DM1 is caused by an expansion of trinucleotides in the DMPK gene, leading to accumulation of RNA foci and deregulation of RNA metabolism. The mutation was identified in 1992 but aspects of its pathophysiology are not understood and there is no cure.A promising area of research is the potential alteration of the m6A epitranscriptome in DM1. A major discovery in gene regulation is the presence of modified nucleotides like N6-methyladenosine (m6A), which affect RNA fate. Defects in m6A have been linked to various diseases but its role in muscular dystrophies including DM1 remains unexplored. m6A is regulated by writers that add and erasers that remove the modification. In DM1, the erasers FTO and ALKBH5 are deregulated. Once added m6A marks are recognised by readers which mediate their cellular effects. m6A readers are crucial to skeletal muscle physiology but their involvement in DM1 is unknown.EpiDM project hypothesises that altered m6A demethylases activity leads to hypermethylation, impacting RNA function and muscle physiology. Its objectives are to 1) map and characterize m6a’s role in DM1, 2) identify m6A readers involved in the disease and 3) explore the therapeutic potential of targeting m6A methylation to restore muscle function.My expertise will be combined with the host lab’s by leveraging DM1 models and next-generation sequencing techniques to study m6A and RBPs, and developing innovative therapies. By pioneering this research EpiDM will uncover the regulation of novel RNA pathways in skeletal muscl
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Machiavelli and Machiavellism in Japan: 1868-1968. For an Intellectual History of Realism from its Outskirts' (Makyaverri).

assistant: **Innovation**

The project studies the fortune in the modern and contemporary Japanese culture (1868-1968) of the notion of Machiavellian realism—the representation of Machiavelli as the father of modern Realpolitik. The analysis will focus, in particular, on the relationship between realism and conflict, which has been fundamental in the nineteenth and twentieth century historiography on Machiavelli as well as in the Japanese discourse on national identity. The inquiry will not address the Japanese interpretations of Machiavelli as an isolated case, but will explore their relations to the wider consideration that the Italian thinker enjoyed in the West, especially in the US and Italy. Through the study of the transfers, exchanges, and interactions between the Japanese interpreters and their European and American colleagues, we aim at sketching a global history of Machiavellism and modern realism from the eccentric perspective of Japan. Our expectation is that, by doing so, we will be able to question some of the fundamental assumptions lying behind the conception of realism as it established itself in mainstream modern politics. In the proposed project, supervision by an expert in Machiavelli and a theorist and methodologist of Global Intellectual History will help the experienced researcher, who has a background both in early modern Italian thought and Japanese intellectual history, to produce a truly global reflection without loosing theoretical depth and historical accuracy. The final goal is to reach out to a wide audience of academics, non-academic experts of foreign policies and interested laymen, showing the potential for intellectual history to contribute to extra-academic debates on global politics. Training will not only focus on specific skills and knowledge within the fie
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Seventh Framework proposal for the project 'Coordination of national environment and health research programmes - Environment and health ERA-NET'.

assistant: **Objectives**

It is estimated that around 20% of the burden of disease in industrialized countries can be attributed to environmental factors, and the magnitude of the problem is perceived by the majority of Europeans. The assessment of health impacts is based mostly on scarce exposure data and limited information on the relationship between exposure and health. There is, therefore, a need to strengthen research in this area and to develop methods and tools which will improve the comparability of data. Member States have developed skills and expertise using different mechanisms to fund environment and health research. The scientific boundaries created by the remits of different funding organisations have frequently acted as a disincentive to collaborative working. Although aims are towards relevance and efficiency, the results remain dispersed and not of actual support for policy-making. Therefore, results of the studies in ERA-ENVHEALTH will lead to the proposal of a coherent set of proposed priorities, implementation of joint activities, and common calls. ERA-ENVHEALTH, by bringing together 16 participants from 10 countries, will contribute to establish collaboration among the different funding organisations of environmental and public health research communities.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Renewable energy on the high seas – science-informed and indigenous knowledge-based recommendations for regulatory and governance challenges' (2021-2027).

assistant: **Innovation**

The high seas are those marine areas under no State's jurisdiction. So far, all marine renewable energy (RE) activity is being conducted under State's jurisdiction. However, recent advances in technology are raising the prospect of carrying out RE activity on the high seas. Currently, only seabed mining activities in the Area have been regulated. The Area is the seabed and ocean floor beyond the limits of State's jurisdiction. From the legal viewpoint, the main gap is a lack of an international regulatory framework, informed by participatory mechanisms and supported by scientific evidence, for RE activities on the high seas, especially regarding their environmental and social impacts. The primary project objective (O) is to provide the scientific community and policymakers with science-informed and indigenous knowledge-based recommendations in support of the development of  RE regulation on the high seas. Two specific Os are set to complement the primary O, namely:O1 To advance the use of systematic consultation processes that facilitates research at the crossroads of marine sciences and law. O2 To advance critical knowledge and understanding of environmental pressing issues comparable to the regulation of RE on the high seas, such as deep-sea mining in the Area.A multistep innovative methodology will be adopted, by integrating marine scientific knowledge, consultative processes, and advanced critical research in the subject matter. A case study (interdisciplinary and participatory) involving marine scientists, indigenous and coastal communities and policy makers will be conducted onboard the Research Vessel KronPrins Haakon at the beginning of the project. The case study outcomes will be analysed through critical legal analysis to build a knowledge base for policy reco