RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Developmental trajectories for model-free and model-based reinforcement learning: computational and neural bases' to be submitted under Seventh Framework.

assistant: **Abstract**

Adolescence is defined as the period of life that starts with the biological changes of puberty and ends at the time at which the individual attains a stable, independent role in society. During this period, decisions are characterized by being impulsive and high-risk, and this can have serious consequences, for example accidents caused by dangerous driving and experimentation with alcohol and drugs. It is thus important to understand the neurocognitive processes that underlie decision-making in adolescence.Decision-making depends on the interaction of several component processes, including the representation of value, response selection and learning. In reinforcement learning all these processes are integrated. Reinforcement learning deals with the ability of learning to improve one’s future choices in order to maximize the occurrence of pleasant events (rewards) and minimize the occurrence of unpleasant events (punishments).Theoretical models for reinforcement learning postulate the existence of a dual controller for action selection: ‘Model-free’, which is computationally simple, more reflexive and inflexible and ‘Model-based’, which is more reflective and flexible, but computationally complex.The development of reinforcement learning in human adolescence has been studied only recently. Studies to date have not attempted to disentangle model-free and model-based behaviour. The aims of the current project are: i. to map the development of reinforcement learning systems – via behavioural/computational analysis - and ii. to relate the maturation of model-based reinforcement learning to the functional maturation of specific neural circuits – via functional magnetic resonance experiment.This study will provide further insights in adolescent reward-based decision-making an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Comparative analysis of intraspecific song variability in lark species (Alaudidae) with different degree of population fragmentation' (Alaudidae) targeting Sixth Framework.

assistant: **Abstract**

In passerines, micro and macro geographic patterns of song differentiation are a well-documented phenomenon. Macro geographic variation is recognized by the presence of song variants encompassing extensive populations of a species, whereas micro geographic variation occurs where distances between populations are small and point out to local dialect systems. Songs can exist as several dialects forming a geographic mosaic in which interbreeding individuals within a population share song themes that are different from those of adjoining groups. By means of positive assortative mating or limiting dispersal opportunities, song dialects potentially act as a behavioural barrier to maintenance of genetic variability in populations which would otherwise be considered large enough to remain stable in conservation terms. With this project, we focus on intraspecific song variation and population spatial organisation of seven larks (Chersophilus Dupont, Melanocorypha calendar, Galleria thecae, G. cristata, Calandrella brachydactyla, C. refastens, Aloud ardencies; Aves, Alaudidae). The differential degree of population fragmentation characterising the different species make them a good study subject to test for the effects of spatial isolation on song patterns, both at micro-geographic and macro-geographic scales. All these species have an unfavourable status (and one-C Dupont- is now endangered of extinction); hence, the analysis of interoperation variation in song structure may help in assessing population dynamics and the potential role of dialect differentiation in population splitting and isolation. Evidence from bioacoustics will be compared and integrated with other sources of information (genetics, radio tracking, dispersal), helping to create a touchstone for the study of bi
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'PROtist PATHobiome-INvertebrate interactions: a multi-approach to understand marine diseases of commercial bivalves', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Marine disease outbreaks can devastate populations, alter community structure and affect ecosystem health, which results in biodiversity loses and economic impacts on ecosystem services. Bivalves, which mediate ecosystem processes and functions and provide ecosystem services (e.g. food), harbour a wide variety of protists in their microbiome, including parasites and pathogens. Protist species produce important economic losses on the world’s leading shellfish industries due to parasitic disease outbreaks in bivalve hosts and the transmission of pathogens affecting human health. Although the economic implications of these outbreaks in shellfish aquaculture are significant, very little is known regarding their biology and ecology. In this context, PROPATHIN project is designed to advance our knowledge on marine and food-borne diseases caused by microbial eukaryotes (protists) associated to commercial bivalves, through the multidisciplinary study of protist-bivalve interactions at molecular, cellular and community level. I will employ recently developed molecular (metabarcoding) and ‘omic techniques (single-cell genomics and transcriptomics) coupled with traditional cell biology methods for diagnose of infectious organisms in multicellular hosts. I will assess the diversity, composition and dynamics of oysters and mussels pathobiome in the Ebro Delta aquaculture setting during a year cycle. Environmental parameters will be used to assess the dynamics of such hazardous protists related to seasonal changes. Further, we will sequence the genome and transcriptome of a protist parasite (including different life-cycle stages), from which very little information exists, revealing the genes involved in the infection of bivalve hosts. Overall, PROPATHIN will help us disentangle the
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Synaptic transmission in the neocortex' goes beyond current state-of-the-art under Fourth Framework.

assistant: **Innovation**

Research objectives and content The objectives of the proposed research are to determine the properties of excitatory synaptic transmission at the level of individual synapses between pyramidal neurons of the neocortex. Combined electrophysiological recordings and calcium imaging will be performed on connected layer 2/3 pyramidal neurons in brain slices using the whole-cell patch clamp technique and confocal imaging. This will allow the isolation of postsynaptic responses from single synaptic connections at well defined locations on the dendritic arbor. In addition, it will be possible to correlate the postsynaptic response with both presynaptic and postsynaptic changes in calcium concentration.This technique will make it possible to gain a better understanding of several poorly understood properties of synaptic transmission. Through the measurement of presynaptic calcium changes it will be possible to examine some possible causes for failure to release transmitter in response to action potentials generated at the soma. It will also be possible to determine the variability in postsynaptic responses at individual synapses. Finally, the influence of the location of the synapse with respect to the somas of the presynaptic and postsynaptic neuron will be investigated. Training content (objective, benefit and expected impact) The laboratory of Prof. Dr. Sakmann has developed excellent techniques for studying synaptic transmission between connected pairs of pyramidal neurons in the neocortex through a combination of electrophysiology and calcium imaging. The proposed project takes full advantage of this expertise of the laboratory and I will thus be able to learn the techniques involved in making paired recordings from connected pyramidal neurons in the neocortical slice toge
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write clear, measurable objectives and define the scope for the project 'Greenhouse-gas removal apprenticeship and student Program' (GRASP) under Sixth Framework.

assistant: **Objectives**

The concern of this Marie Curie Research Training Network (RTN) is global warming due to the increase of greenhouse gases in the atmosphere. The training and research effort lies in greenhouse gas (GHG) removal, focusing on geological GHG storage. Three major work packages aim to address the issues of capacity and sustainability of a geological GHG storage place: wellbore isolation to counter any eventual GHG leakage from the injected formation to another or to the surface and to ensure sustainability, reservoir characterization to evaluate the capacity and sustainability of the targeted injection formation and storage monitoring to quantify an eventual GHG leakage to the surface.The multidisciplinary partnership of Academia and Industry merges the sciences of geophysics, physics, geology, microbiology, chemistry, mineralogy, mechanical and electrical engineering, mathematics and rock-mechanics to provide solutions for and to train a new generation of young researchers in GHG storage issues for the next decades. The network will organize a well-structured multidisciplinary training and knowledge transfer (ToK) program. Early-stage and Experienced researchers will attend advanced network-wide courses, technical individual training and soft and complementary skill courses run by the partners to develop a full proficiency.Organization of workshops, summer schools, and participation in international conferences will be important elements of the training program where young researchers can communicate their results and exchange knowledge between the research teams. Another communication and evaluation platform will be meeting the scientific committee, which evaluates the research progress and quality, and the training and ToK committee, which asses the ToK activities and pla
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'The NUTRI-CHECK NETwork to maximise site-specific precision in managing the nutrition of European arable crops.', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Europe faces huge and urgent challenges of increasing crop productivity whilst reducing use of synthetic fertilisers and nutrient losses. This proposal is to establish a self-sustaining, multi-actor, Thematic Network called “NUTRI-CHECK NET” that builds farm-level adoption of best field-specific nutrient management practices across Europe. In nine countries farmers’ Crop Nutrition Clubs (CNC) will identify and share the nature of their uncertainties about crop nutrition, their challenges and barriers to change. Decision-systems and nutrition tools (including commercial products, services, and recent research outputs) will be assembled by national experts from across Europe, including leading farmers, into a common online NUTRI-CHECK NET platform. CNCs will then evaluate effectiveness of new protocols and tools selected from the a toolbox to meet their main challenges. Thence they will co-create and adopt farm- and field-specific ‘measure-to-manage’ approaches that address their crop nutrition challenge(s). Evaluations of protocols and tools by farmers and experts will address their ease of use, trustworthiness, costs, and benefits. Initial and final evaluations will be shared across the Network to define ‘best practices’, which will be demonstrated and disseminated widely, including through liaison with other relevant Thematic Networks and EIP-AGRI. The toolbox and best practices will be held accessible and improvable in perpetua on EU FarmBook. Widespread adoption of ‘measure-to-manage’ or ‘check-to-change’ approaches to crop nutrition will enhance nutrient recycling and crop productivity, whilst reducing synthetic fertiliser use and nutrient losses across Europe.


**Keywords:** Sustainability, Nutrient Management, Arable Crops
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an executive summary for the EU project 'Ultrafast broadband sensitive magneto-chiroptical microscopy to track the consequences of symmetry breaking in solution-processable semiconductors' (MACHIRO) targeting Horizon Europe.

assistant: **Abstract**

Chiral solution-processable semiconductors are a new class of materials that could revolutionize optoelectronics by enabling circularly polarized light (CPL) emission and spin control without external magnetic fields at room temperature. This could enhance the efficiency of displays, solar cells, holography, cryptography, and biomedical imaging, while opening new possibilities in quantum information processing. However, current trial-and-error approaches, limited by the absence of suitable techniques to probe mechanisms, prevent systematic breakthroughs in designing chiral materials with strong CPL emission and spin polarization.MACHIRO will overcome these limitations. We will develop the first ultrafast broadband magneto-chiroptical microscope to map the Stokes vector of light polarization emitted from chiral materials with diffraction-limited spatial and femtosecond-temporal resolution. This will enable us to directly track the interplay between charge, spin, and light polarization in time and space, to mechanistically understand how CPL and spin polarization arise from structural chirality imprint on the excited state.We will use this new tool to study a range of i) heavy-element containing chiral halide perovskite semiconductors, as well as ii) purely molecular twisted materials with much less spin orbit coupling. We will systematically vary dimensionality (3D bulk to 0D quantum dots), hierarchical level of chirality, helical pitch and addition magnetic impurities, while always monitoring the role of local disorder through mapping. Thus, we will identify dominant loss channels and arrive at a unified mechanism of how light and spin polarization are connected.Finally, we will integrate insights across all materials, establishing universal design rules for using chira
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Metabolic imprinting of Th17 cells in disease pathogenesis' (2021-2027).

assistant: **Concept**

Autoimmune diseases affect an estimated 3-9% of the population and cause major personal and socio-economic consequences. IL-17-producing CD4+ T cells (Th17) are recruited to inflamed tissues and involved in autoimmune pathogenesis but were recently also shown to have homeostatic function in tissues. Preliminary data from the outgoing host indicate that Th17 cells are transcriptionally distinct in different tissues. How tissue Th17 cells acquire such specialized characteristics remains elusive. Based on recent findings from the lab that a metabolic manipulation affects Th17 cells, we hypothesize that metabolic cues from the target tissue dictate Th17 phenotypes. To address this, we will apply scRNAseq and the host lab developed Compass metabolic flux tool in 9 tissues. Hits from this analysis will undergo a novel screening approach, CHIME, to reveal effects on Th17 function. In autoimmunity, Th17 cells reside within different tissues before migrating to the inflamed tissue. Identifying a tissue metabolic switch for Th17 cell pathogenicity might thus pave the way for novel treatments. To study this, I will use a mouse model for the autoimmune disease multiple sclerosis (MS) for target validation. During the return phase, the findings will be set into context of tissue niche immunology and human biology. In healthy versus inflamed human tissue, spatial RNAseq will directly reveal metabolism related differences in a natural tissue niche context. The project will be performed in a world-renowned Th17 lab. The fellow brings extensive experience with tissue immune cell extractions and MS mouse models, enabling immediate project progression. The fellow will then bring back novel techniques and experience (scRNAseq, CHIME) to the return host, where she will acquire skills in hum
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write a project proposal abstract for 'Structure and classification of C*-dynamics' to be submitted under Horizon 2020.

assistant: **Abstract**

We study group actions on C*-algebras from a structure and classification point of view, importing concepts from the Elliott classification program into the equivariant context. The challenge is to advance the structure theory for natural classes of actions of amenable groups on C*-algebras. In a similar vein, we shall consider flows on C*-algebras, which are the mathematical abstractions of time evolutions. The objectives of this proposal are:A: Establish an Ocneanu-type rigidity result for actions of amenable groups on strongly self-absorbing C*-algebras as well as the automatic tensorial absorption of such actions under natural conditions.B: Obtain an equivariant version of the KK-theoretic stable uniqueness theorem à la Lin-Dadarlat-Eilers.C: Study the rigid behavior of flows on Kirchberg algebras with the Rokhlin property, in order to solve a long-standing open problem set out by Kishimoto. We also consider other natural classes of flows without the Rokhlin property, the projected classification of which will solve open problems such as Robert's conjecture and part of the Toms-Winter conjecture.The solution to this challenge employs equivariant generalizations of important classical concepts like strong self-absorption, W*-bundles, KK-theory, and combines these with known concepts like Rokhlin dimension in an innovative way. The projected results are ground-breaking for the field of C*-algebras, and the methods to obtain them go well beyond the state-of-the-art. The projects are chosen to maximize the transfer of knowledge between the ER and the supervisor. Taking into account the excellent opportunities for professional training and public engagement provided by the University of Aberdeen as well as the other suggested activities described in the proposal, the MSC
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe how 'BioSim M2M: Molecules to Medicine' will create measurable scientific, societal and economic impact aligned with Horizon Europe.

assistant: **Impact**

BioSimulytics has developed breakthrough technology combining quantum physics, computational chemistry, machine learning, and high-performance computing to boost the success rates of pharmaceutical R&D. The BioSimulytics invention (patent EP3948877A1), is being applied to crystal structure prediction (CSP) for determining the most stable crystal structure or polymorph of a drug compound, as well as the most stable binding poses in protein-ligand complexes.Existing state-of-the-art techniques for polymorph analysis require long and painstaking experimentation by material scientists with uncertain results (<1% success rates). BioSim M2M will reduce the time to find the most stable crystal structures of a molecule from 3 months to 3 weeks and reduce candidate experiments from 400 to 40. As a result, BioSim M2M will contribute to the Pharmaceutical Strategy for Europe by helping to ensure that patients have access to high quality, effective, and safe medicines.