RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Micron-scale Ice Core Reconstruction of Abrupt Climate Changes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Understanding natural climate dynamics is fundamental to anticipate, avoid, and assess mitigation potential for abrupt climate change, one of the grand challenges to global sustainability. As one of the most important natural archives, polar ice cores have led to the discovery of past abrupt climate transitions, such as the abrupt onset of stadial-interstadial warming in Greenland, happening as fast as just a few decades. The underlying processes remain to be fully deciphered, especially whether oceanic or atmospheric changes initiate abrupt changes, or if they act simultaneously. To study the sequence of events requires fine temporal detail, which conventional cm-resolution melting techniques cannot provide due to continuous thinning of ice layers. Laser-Ablation Inductively-Coupled Plasma Mass Spectrometry (LA-ICP-MS) is a key technology in this respect, offering micro-destructive ice core impurity analysis at micron scale-resolution. At this high resolution, however, it is pivotal to avoid misinterpretation by taking into account interaction of impurities with the ice crystal matrix. MICRO-CLIMATE brings together, for the first time, two state-of-the-art LA-ICP-MS setups (at the Universities of Maine and Venice) to realize what one partner could not achieve alone: high-throughput AND high detail analysis for constraining signal preservation. In Venice, imaging the 2D impurity distribution detects the imprint of the ice matrix. In Maine, impurity profiles over meter-long ice core rods are investigated to decipher the timing of changes in marine, terrestrial and atmospheric proxies, before, during and after abrupt transitions. By this means a high-resolution fingerprint of the abrupt change is unfolded – which climate components change first, which follow? Ultimately,
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Magnetic Sensors with No Remanence for Aircraft Application', explaining its relevance to EU policy priorities under Seventh Framework.

assistant: **Impact**

The objective of this project is to leverage on a breakthrough nanotechnology invented by a French SME, Neelogy, for high performance isolated magnetic sensors with no remanence, and adapt it for harsh environmental avionics constraints (high amplitude variation of operating temperature -60° to +125°C, depression, humidity, vibration and EMI/EMC constraints).The same technology will be used for both current and voltage sensors.Neelogy is the only participant to this project, but they are supported by subcontractors, who are experts in avionics standards and recommendations, especially for the electronics parts.The project duration is 42 months. The goal is to have 5 prototypes of current sensors and 5 prototypes of voltage sensors at the end of the project, as requested in the Call for Proposal. With regard to commercial products, the objective is to have them available 1 to 2 years after the end of the project.The project is organized in 16 Work Packages (in summary: simulation tools, test benches, design of measurement heads for Current and for Voltage, design of discrete analog and digital electronics, design of mechanical parts, test of mock-ups and prototypes, design of PCB, specification of ASIC).It represents an effort of 62 Person-Months for Neelogy (internal resources). A scientific project manager, as well as a project coordinator will be assigned.The total budget is 600k€ (515k€ for Research & Technology Development, 55k€ for Demonstration, and 30k€ for Management). It is spread as follows: 55% to Neelogy and 45% to Neelogy’s subcontractors.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Random Copolymers Enabling  Nonimmunogenic PEGylation for Medical Therapeutics' (RandoPEGMed), addressing dissemination and exploitation.

assistant: **Impact**

PEGylation, the attachment of the highly hydrophilic, biocompatible polymer polyethylene glycol (PEG) to therapeutics, has become a key strategy in current nanomedicine. PEGylation is indispensable for a broad variety of commercial therapeutics. They range from protein drugs to relevant nanocarriers, such as liposomes and lipid nanoparticles. PEG leads to the particular stealth effect, i.e., strongly prolonged blood circulation times and apparent invisibility for the immune system. This is also used for lipid nanoparticles (LNP) transporting mRNA vaccines, used worldwide against the COVID-19 pandemic. However, this powerful weapon is now in danger of becoming blunt: An increasing body of literature from immunologists, clinicians and biochemists shows a rapid increase of individuals (50-70% in industrialized countries) possessing anti-PEG antibodies (APAs). This causes undesirable rapid elimination of PEGylated drugs from the bloodstream, hypersensitivity and strong allergic reactions. RandoPEGMed introduces PEG-derived random copolymers for nanomedicine. These PEG copolymers with well-defined chain length possess randomly distributed point mutations along the chains, which both disables recognition by the immune system and formation of antibodies. The project will thus exploit monomer sequence statistics to eliminate immunogenicity, representing a radically new approach in polymer therapeutics. One pivotal aim is precise understanding of monomer sequence statistics in the anionic copolymerization of glycidyl ether monomers with ethylene oxide (EO). At the interface of polymer synthesis, pharmaceutical chemistry and medicine this project aims at preserving the benefits of PEGylation for the future. Based on our preliminary results and the hypothesis that anti-PEG antibod
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'Designing the railway of the future: Fire resistant composite materials and smart modular design' (Mat4Rail).

assistant: **Innovation**

Europe’s railway industries require a step change in technologies and design for the next generation of rail vehicles in order to remain competitive globally. Innovative materials and modular design for rolling stock are considered to become key to success. Composite materials with their unique properties (lightness, repairabillity, corrosion resistance…) have demonstrated a high potential for lighter, more energy- and cost-efficient structural components in relevant sectors such aeronautic or automotive industries. However, currently available structural composites do not meet Fire, Smoke & Toxicity requirements of the railway sector, and thus cannot be used for the manufacturing of carbodyshell parts.Mat4Rail will face these challenges through a two-tier approach: In work stream I, our materials team (including resin producers, composite manufacturers, and experts on joining technologies and testing) will: i) synthesize novel fire retardant resins (epoxy, benzoxazine or hybrids) and manufacture composite batches; ii) modify fatigue and static load cases according to new requirements for polymeric materials; iii) further develop structural adhesive bonding combined with riveting and bolting for permanent and non-permanent joints and the repair of the new composites; and iV) assess novel design concepts for access door systems using new materials and joining technologies. In work stream II, our specialised design and engineering teams will develop new concepts for interior design of rolling stock including: i) plug and play systems which function like a limbic technical and power system for new electric utilities; ii) innovative lightweight seats and iii) a compact and ergonomic driver’s desk. Together, our multi-disciplinary consortium of 7 SMEs, 3 large industries, 5
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Traditional United Europe Food' (TRUEFOOD), addressing dissemination and exploitation.

assistant: **Impact**

The proposed Integrated Project (IP) aims to improve quality and safety and introduce innovation into Traditional European Food production systems through research, demonstration, dissemination and training activities. It focuses on increasing value to both consumers and producers and on supporting the development of realistic business plans for all components of the food chain, using a fork to farm approach. The proposed project has 5 main objectives: (i) Identify and quantify consumer perceptions, expectations and attitudes with respect to (a) safety and quality characteristics of traditional foods and (b) innovations that could be introduced into the traditional food industry. (5 % of project effort) (ii) Identify, evaluate and transfer into the industry innovations which guarantee food safety, especially with respect to microbiological and chemical hazards (20% of effort). (iii) Identify, evaluate and transfer into the industry innovations which improve the nutritional quality, while at the same time maintaining or improving other quality characteristics (e.g. sensory, environmental, ethical) and recognised by traditional food consumers (35% of effort) (iv) Support the marketing and supply chain development of traditional food products (10% of effort) (v) Facilitate effective technology transfer of innovations (those developed within the TRUEFOOD projects and in other EU, national and industry funded R&D projects) into traditional food industry (30% of effort)...
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'Specifications enhancement through case and SDL' (SPECS).

assistant: **Concept**

The SPECS Project aims at introducing SDL based CASE tools as a support to the analysis/ design/ coding activities of Italtel BURM (Business Unit Reti Mobili), a Europe's leading full-line manufacturers in the telecommunications field.The PIE falls within the scope of a large Process Improvement Program running at Italtel BURM after a process assessment performed in June 1995. In this context, the baseline project will be a major release of a Network Element of a GSM system.ACTIONSThe objectives will be achieved through the adoption of SDL (Specification and Description Language), a formal specifications language particularly suited for specifying and describing real-time systems (and thus for telecommunications software development projects).The adoption of SDL will be supported by the adoption of the SDT CASE tool-kit.The distinguishing characteristics of the PIE can be identified as follows:tool selection, in order to procure the tools that better adhere to the specific needs;customisation for the specific environment, in order to adhere to the peculiarities of the proprietary operating system;pilot application, to run the experiment;analysis of results, to evaluate the success of the initiative;preparation for deployment and widespread adoption, if the analysis activities bring to positive results.EXPECTED IMPACT AND EXPERIENCEThe PIE is expected to have a direct impact on several quantitative indicators such as Timeliness, Fault rate in analysis/design, Productivity. In particular, the main goals of the PIE are represented by the increase of the software productivity in development and the availability of better documentation both for internal usage and for customers; those aspects indeed have a direct influence on the costs and quality of the delivered products an
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Community-based engagement and intervenTions to stem the spread of antimicrobial resistance in the aqUatic environments catalysed by cLImate change and Plastic pollution interactions', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Interconnections between ecological and societal systems facilitate compounding impacts of climate change, environmental plastic pollution and proliferation of antimicrobial resistance (AMR) on the health of people, animals and ecosystems on a planetary scale. Current knowledge on interactions between these three crises in the Earths natural systems and their impact on health is highly restricted. TULIP will apply a transdisciplinary socio-ecological systems thinking approach, robust environmental science methods, epidemiology, modelling, sampling design and state-of-the-art molecular tools to generate scientific evidence on plastic-AMR interactions. It will describe spatio-temporal dynamics and patterns of plastic-associated AMR under a changing climate and the compounding health and ecological impacts. It will employ the methodology of intervention and social sciences to explore social driving factors and current policies and design and evaluate community-based interventions and nature-based solutions. TULIP will convert created evidence to modelling-based decision-supporting tools that approximate co-benefits to human and ecosystem health, indicators and environmental policy recommendations highlighting triple-win solutions and foster the science-policy translation using an integrated knowledge translation framework. Aiming to ignite a lasting societal change toward health-promoting environments, TULIP will engage communities, citizen scientists, policymakers and experts from multiple sectors in research, co-design, co-implementation, communication and dissemination processes. TULIP will focus on aquatic environments as they create a milieu for interactions, transport pathways and exposure interface and showcase its approach in the Philippines and Italy and translate
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'A Shell-and-tube heat exchanger enhancement that increases Energy Efficiency in the Oil, Gas, Power & Chemical Process Sectors' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

In oil refineries, the Pre-Heat Train (PHT) is a network of usually shell-and-tube heat exchangers which aims to reduce the energy requirements in the crude distillation unit, i.e. the unit where the fractionation of the all the crude-oil takes place. When the PHT does not work efficiently, more fuel must be burnt in the downstream furnace. A typical decay rate in the coil inlet temperature in the PHT is 2-5℃ per year, or 8-11℃ per year according to less optimistic estimates. A yearly average drop of 5℃ costs a refinery about €1 - €1,5 million. A 1℃ drop in the furnace coil inlet temperature has been reported to cost for a UK refinery (processing 210,000 bbl per day ) ca. €400,000 per year. There are several modifications or enhancements that can improve heat exchanger efficiency, but unless they are installed during manufacturing, it is not cost efficient to apply them after the heat exchanger has been put to operation. The Flow Enhancer is a shell-and-tube heat exchanger enhancement that improves crude oil flow from the header’s inlet towards the heat exchanger’s tubes. It ensures reduced turbulence, a 10% increase in tube inflow velocity and a corresponding 7°C increase in outlet temperature. The potential savings to refineries could reach up to €1.8m per year and a 9:1 return on investment.In order to ensure the adoption of the technology, we have formed a partnership that brings together all the necessary elements: technology, manufacturing, commercialisation and scientific analysis to develop a marketing strategy based on proven results. The Flow Enhancer will increase the efficiency of European and global refineries, with significant environmental benefits, as it results in a reduction of 8 tonnes of CO2 per day for each 100k barrels processed, and has the potent
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Dopaminergic neurons from human embryonic stem cell grafted in models of Parkinson's disease' goes beyond current state-of-the-art under Sixth Framework.

assistant: **Innovation**

State of problem: Grafting of primary embryonic neural tissue has proven that cell replacement therapy is a viable approach to the treatment of PD. However, the number of successfully grafted patients is relatively small due to limited access to suitable donor tissue.Alternative sources of donor tissue - which are reproducibly homogeneous in their cellular composition and can be generated in large quantities - are urgently needed for cell transplantation to become a widely available therapy for PD.Overriding objective: To propagate human embryonic stem (hES) cell lines and differentiate them into dopaminergic (DA-ergic) neurons, which can be used for neural grafting in Parkinson's disease (PD).Aims of the present project:- To expand cells from hES cell lines established by Lund University collaborators (SAO1 (Cell Therapeutic Scandinavia AB, Goteborg, Sweden) and #237 (Karolinska Institute, Stockholm, Sweden)) and to identify epigenetic stimuli that promote their differentiation into a uniform, enriched population of DA-ergic neurons.- To assess the DA-ergic phenotype of the hES-cell-derived neurons in vitro, regarding the expression of markers for dopamine production and handling, and exhibition of spontaneous firing as well as spontaneous and drug-induced dopamine release.- To assess the ability of grafted hES-cell derived neurons to restore DA-ergic neurotransmission in vivo by examining their effects on behaviour in immunosuppressed hemiparkinsonian rats and their capacity to produce and release dopamine, as well as to form synapses.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Anthropogenic Heathlands: The Social Organization of Past Grazing Landscapes', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

In a time of accelerating human-caused ecological catastrophe, questions of organizational resilience have become extremely timely. In bringing the archaeological perspective of a 4200-year timespan, ANTHEA seeks to to radically alter our knowledge of resilient forms of self-organisation in past land-use regimes and human-nature entanglements. Based on seven case study areas, ANTHEA will show how collaborative institutions of common land use were organized in the North European heathland regimes (3200 BC-AD 1000), with a particular emphasis on their earliest emergence, their adaption to internal and external factors as well as their ecological, temporal, spatial, and social fabric. More than 4,000 years ago, farming communities across northern Europe began the first fire-based expansion of naturally occurring heather. Pollen evidence suggests that some of these grazing areas, spanning thousands of hectares, existed until the 18th-19th century. Without frequent intervention and management, anthropogenic heathland will turn into forest. So the survival of these areas suggests the existence of highly specialised forms of social organization with the unique capacity to persist. Still, we know little about the actual stability of these heathlands or what caused their unprecedented resilience. By shifting attention away from seeing institutional robustness as equilibrium, stability and continuity and placing the questions of instability, uncertainty, and areal flexibility at the centre, ANTHEA envisages a new cultural history of heathlands that breaks with rooted ideas of these areas being marginal and underdeveloped. ANTHEA is truly multidisciplinary and links landscape and settlement archaeology with paleoenvironmental modelling, social anthropology and philosophy. Moreover