RCaz/eu-funding-proposals-sft huggingface dataset:
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain the overall concept, methodology and approach for the project 'EUROPEAN DEVELOPMENT OF BIONICS VESTIBULAR IMPLANT FOR BILATERAL VESTIBULAR DYSFUNCTION' (BionicVEST).

assistant: **Concept**

Vertigo of vestibular origin has a global prevalence of 38% in the elderly and deserves special attention becauseof the high risk of falls and permanent functional disability, and even death. This seriously handicaps their lives,disabling them of doing routine daily activities, such as driving and even walking. The associated total costs arearound 60.000 million euros in Europe. It is estimated that at least 100 million people worldwide could benefitfrom a vestibular implant as an effective solution to this disease. Restoring the function of the vestibularlabyrinths was not possible until now. Current devices, under research, detect change in angular velocity of thecephalic movements through gyroscopes and use this information to stimulate the semicircular canals. However,they do not code vertical and horizontal accelerations, used to sense gravitational forces, keep a stand up positionand restore the sense of self-position. Linear accelerations are detected by a different set of structures which are amore complex and harder to access: the saccule and utricle. This project will develop the first system toelectrically reproduce linear accelerations in the otolith organ by stimulating their neural ends. The project willhave three phases: Device design, fabrication and clinical trial. Therefore, the objectives will be: 1) to study, forthe first time, vestibular pathways through electrical saccule-utricle stimulation; 2) to develop a vestibularresponse telemetry system to analyse the evoked action potential of vestibular nerve; 3) to design, manufactureand test the first vestibular prosthesis that restores the sense of linear accelerations. The main objectives are todemonstrate the safety of a vestibular implant for human, to determine its efficacy in restoring vestibular f
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft the 'Objectives and Scope' section of a Horizon Europe proposal for the project 'Heart Attack Monitoring Patch (HAMP)'.

assistant: **Objectives**

Every year more than 60 million people live with Cardiovascular Disease (CVD), and more than 1.8 million people die as a result of CVD, accounting for 36% of all deaths. Among different types of CVD, heart attack and stroke are the leading cause of death in the EU. The recognized guidelines identify the first one hour after the onset of a heart attack as the golden hour to receive proper medical assistance and prevent death or damage to organs. Hence, there is a vital need for a compact and easy-to-use biosensing platform that can be used outside hospital settings by the patient or the ambulance staff for diagnosis of heart attack within the golden hour. NT-pro-BNP is a desirable biomarker due to its fast release kinetics, higher circulation levels and lower fluctuations. Although significant advances in NT-pro-BNP biosensors generations have been achieved, these face some serious limitations as most of them cannot be used outside hospital settings, requiring physical attendance of patients which leads to losing time (beyond the golden hour) and increased risk of death. In this project, I propose – for the first time – a wearable and wireless system for early and quick diagnosis of a heart attack outside the hospital setting. The Heart Attack Monitoring Patch (HAMP) that I propose here, is composed of an AC Electrokinetic (ACEK)-based fast-response label-free NT-pro-BNP biosensor, microneedles array for interstitial fluid sampling and data processing, and wireless communication circuits. Although the ACEK phenomenon is a well-established method for the design of rapid biosensors, this is for the first time that the ACEK effect is employed by a wearable biosensing system for high speed (less than a minute) and low LOD (below 1 pg/mL) detection. The HAMP has a compact and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose a compelling abstract for 'Using super-resolved in situ sequencing to reveal the cellular encoding of immune-tumour contact events' demonstrating excellence, impact and implementation quality for a Horizon Europe call.

assistant: **Abstract**

Despite the constant surveillance of immune cells, tumour cells can still evade the immune response. Unravelling the interactions of T cells and B cells with tumour cells can shed light on tumour evasion. Extensive research is focused on the mechanisms of activation of an immune response in T cells. However, it is known that detection events, i.e., physical contact between individual surveying T cells and tumour cells, don’t necessarily lead to such activation. Little is known about physical interactions between T cells and tumour cells that do not end in activation. Here I suggest focusing on these detection-without activation events. In these cases, how is the detection information encoded in T cells? i.e., How are T cells and other immune cells affected by the interaction with tumour cells on the molecular level?. My working assumption is that the evading mechanism can be manifested as a physical change in immune cells upon touching tumour cells, and I suggest detecting the ‘smoking gun’ of this process in biopsies, in the form of changes in the gene expression program of touching immune cells. This was not done before because it is almost impossible to study single interacting cells in tumour tissues. It requires both high spatial resolution, to detect individually interacting cells, and high molecular resolution, to quantify cell types and states. Here, using a technology I developed for in situ sequencing with super-resolution, I will generate the first dataset of super-resolved spatial genomics mapping of human biopsies and detect tens of thousands of individual interactions between physically touching immune and tumour cell types. I will then build a new imaging technology to sequence T cell and B cell receptor in situ and detect tumour-specific ones, and will b
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Nu Flavour:  Novel Effective Field Theory and Simplified Model Approaches to Beyond-the-Standard Model Flavour Physics and Neutrino Phenomenology' goes beyond current state-of-the-art under Horizon 2020.

assistant: **Innovation**

I propose utilizing model-independent formalisms, e.g. effective field theories (EFT) and simplified models, to study Beyond-the-Standard Model (BSM) flavour physics and associated neutrino phenomenology.  The proposal will consist of two parts, (a) and (b). In (a) I will apply the highly novel all-orders formalism of the Geometric SMEFT (GeoSMEFT) to define and extract neutrino masses and mixings from available datasets, thereby ascertaining the extent to which BSM physics may already be effecting present measurements, and also any implied constraints on candidate ultraviolet (UV) flavour theories. In (b) I will study the phenomenology of Simplified Models of Flavourful Leptoquarks (SMFL) and/or other simplified models invariant under residual family symmetries (RFS), which encode symmetry-breaking effects in UV flavour theories and which can account for potential B-decay anomalies at the LHC, in atmospheric neutrino cascades detectable at IceCube.  Proposals (a) and (b) will be executed in four Work Packages (WP) with the following titles:  WP1: A derivation of mass and mixing quantities within the GeoSMEFT for both Majorana and Dirac neutrino paradigms, including the associated renormalization group flow (RGE) and matching to lower-energy EFTs.   WP2:  A phenomenological GeoSMEFT extraction of neutrino mass and mixing parameters from available datasets.  WP3:  An extension of the RFS formalism embedded in SMFL to account for RD(*) anomalies in addition to, and independently from, the presently addressed RK(*) anomalies.  WP4: The development of the cascade atmospheric neutrino formalism in the presence of flavoured BSM states, and in particular SMFL, and the subsequent calculation of associated conventional and prompt neutrino fluxes at IceCube.  WP1-WP4 will yield i
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Sustainable Plus Energy Neighbourhoods', explaining its relevance to EU policy priorities under Horizon 2020.

assistant: **Impact**

Syn.ikia aims at achieving sustainable plus energy neighbourhoods with more than 100% energy savings, 90% renewable energy generation triggered, 100% GHG emission reduction, and 10% life cycle costs reduction, compared to nZEB levels. This will be achieved while ensuring high quality indoor environment and well-being.Our main strategy for achieving these goals is to deliver a blueprint for sustainable plus energy buildings and neighbourhoods, leading the way to plus energy districts and cities, through:I.Demonstrating new designs and efficient operation of sustainable plus energy neighbourhoods through the balanced application of integrated energy design, energy- and cost-efficiency measures, local renewables, local storage, energy flexibility, and energy sharing and trading. This will be demonstrated in four real-life development projects with plus energy apartment blocks located in four climatic zones and representing four different types of urban development strategies.II.Delivering customized designs, innovative technologies, and decision support strategies and tools that enable informed decisions to be made by the key stakeholders in Europe.III.Encouraging community engagement and empower user’s control facilitated by digital platforms and driven by housing affordability, improved quality of life, and environmental consciousness to inform and enable behavioural change.IV.Unlocking the potential of neighbourhoods as flexibility providers that enable more RES to enter the system and allow for flexible management of energy demand and RES generation in neighbourhoods, to avoid costly reinforcements of distribution grids while improving the quality and reliability of supply.V.Providing big data based infrastructure management and smart networks that, together with new a
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Explain how 'Spin Transport in Silicon Nanodevices' goes beyond current state-of-the-art under Seventh Framework.

assistant: **Innovation**

Spintronics is the vision of using the spin of the electrons instead of its charge to perform information storage and processing. These spin based devices has the potential to make the future computers non-volatile, faster, with memory and processing integrated into a single chip, all with reduced energy consumption. A profound impact on the development of spintronics could come from exploiting spin degree of freedom in the main stream semiconductor like silicon at room temperature.The first goal of this proposal is to establish a physical understanding of the fundamental processes of efficient generation, sensitive detection,  and effective manipulatipon of spin current in silicon. Spin polarization in silicon will be created by different methods such as - electrical spin injection, thermal spin injection, spin pumping, and spin Hall effect using ferromagnet/silicon heterostructures. Detection of the created spin polarization will be performed by combination of different techniques both in local and non-local geometry, for example by use of spin-valve measurements, Hanle measurements and inverse spin Hall effect measurements. Finally the manipulation of such spin polarization will be controlled by magnetic field and electric field. The aim of this proposal is to achieve all these operations in both n-type and p-type silicon at room temperature.The second goal is to implement silicon spintronic devices by integrating different functionalities obtained from our first goal. While relevant for the development of a spin based transistor, this work aims to go well beyond that, aiming for new routes to create and control spins in silicon nanostructures. For realization of this we propose to develop novel approaches for fabrication of silicon based nano-spintronic devices and
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Write the 'Expected Impact' section for the project 'Adaptive wavefront shaping microscope objective lens' (Wavelens), addressing dissemination and exploitation.

assistant: **Impact**

For centuries optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging, even though significantly challenged by light diffusion in tissue, limiting its applicability to superficial depths. Recent advances though have paved the way for exploiting multiple scattering and the increased optical paths to predetermine light propagation, addressing the depth to resolution limits and significantly improve optical imaging capabilities. The currently running DynAMic project in which WAVELENS is linked to aims at revolutionizing microscopic imaging by breaking the depth-to-resolution ratio offering non-invasive, real time, high resolution, multiparametric in vivo imaging, across length scales, deep in biological complex media. Launching from these technology innovations, WAVELENS aims at substantially disrupting the modus operandi of microscopic imaging creating a next generation microscopy capability with enormous benefits for the scientific, industrial and societal community. What this project will achieve is to investigate the commercialization of a completely new line of technology based on the advanced wavefront shaping systems developed within DynAMic up to the proof of concept level, and further engineered and integrated in the shell of a standard microscope objective lens. Spearheaded by this proof of concept prototype, WAVELENS will produce user-defined demonstrator prototypes, a complete market analysis, IP valuation and freedom to operate landscape, a detailed business plan and complete pitching portfolio, providing a concrete foundation for a high-tech spin-off company created during or after the end of the project.


**Keywords:** Wavefront shaping microscopy, adaptive microscope objective lens
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Describe the novelty, innovation potential and advance beyond the state of the art for 'New ways from photon to behaviour: Finding new phototransduction cascades in fan worms' (PhoToBe).

assistant: **Innovation**

Vision is the sense for human beings. We can imagine how the world looks like for animals with visual systems like ours. But for animals with very different visual systems this differs, such as fan worms. Fan worms from different differ in their visual systems tremendously. Some have no visible eyes at all, maybe photosensitive cells not visible without technical help. Others have simple eyes consisting of a photoreceptor and a pigment cell. Others have complicated compound eyes, possibly mediating true vision. The different species form a progressing systems for studying eye evolution. These eyes evolved independently from vertebrate and insect eyes, because they are not in the head but on head appendages called fan. These eyes use also other phototransduction cascades than vertebrates or insects. However, what the exact components are, is unknown. My proposal seeks to answer that question.
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Draft an impact statement for 'Electrochemical reduction of molecular nitrogen to ammonia using plasmonic catalysts: Towards more sustainable ammonia production', explaining its relevance to EU policy priorities under Horizon Europe.

assistant: **Impact**

Ammonia (NH3) production is essential for human development, as it is a key precursor in manufacturing synthetic fertilizers, chemicals, and hydrogen storage. Currently, NH3 is produced via the Haber-Bosch (H-B) method. Achieving sustainable alternatives to the H-B process will significantly contribute to the climate, environmental protection, and energy efficiency goals of the EU's 2030 Plan. The electrochemical reduction of molecular nitrogen (eNRR) to obtain NH3 is one of today's most promising routes. This methodology allows the direct conversion of N2 and water into NH3 at normal temperature and pressure without CO2 emissions. Due to their unique optical properties, an innovative strategy to improve eNRR involves using plasmonic-metal nanoparticles (NPs) as electrocatalysts. The excitation of the surface electrons occurs by illuminating the plasmonic substrates, generating localized surface plasmon resonance (LSPR). LSPR provides an additional source of high-energy electrons to the electrocatalytic system, which can increase efficiency and improve selectivity towards NH3 formation. This plasmonic-electrochemical combination is termed Plasmon-Assisted Catalysis. This research aims to design, synthesize, and characterize plasmonic NPs made of Au, Cu, and Au/Cu alloys to maximize their activity as electrocatalysts for eNRR. The synthesis of NPs with different morphologies will be carried out through various chemical, and hydrothermal methods. The evaluation of the electrocatalytic activity will be conducted in an H-type electrochemical cell and the different synthesized electrocatalysts be supported on carbonaceous electrodes as the working electrode. The activity and stability of the materials will also be evaluated using aqueous and ionic liquids as electrolytes. Fu
system: You are an expert grant writer specializing in European Union research funding proposals. You write compelling, well-structured proposal sections that demonstrate excellence, impact, and implementation quality, using precise EU terminology and following best practices for Horizon Europe, Horizon 2020, and earlier framework programmes.

user: Compose the 'State of the Art and Innovation' section for a Fourth Framework proposal on 'Evaluation frameworks for interactive and multimedia in applications'.

assistant: **Innovation**

Our objectives for the group therefore are:- Bringing the user back into the evaluation process- Understanding the changing nature of IR tasks and their evaluation- Evaluating traditional evaluation methodologies- Considering how evaluation can be prescriptive of IR design- Moving towards balanced approach (system versus user)- Understanding how interaction affects evaluation- Supporting the move from static to dynamic evaluation- Understanding how new media affects evaluation- Making evaluation methods more practical for smaller groups- Spawning new projects to develop new evaluation frameworksOur approach to the creation of new frameworks will be to continue to support and to encourage the research in the evaluation area at the different sites. At the same time the laboratory style evaluation will continue, especially to specify the design of test data to be used in large scale experiments such as TREC. At all times the balance between user-, task-, and system-orientation will be taken into account. Through some of our sites we will have access to real users. Our approach will be to report to each other and subsequently to the wider community about our new evaluation frameworks, mostly through the publication of papers and reports, and occasionally through the demonstration of working evaluation procedures. Moreover, we will attempt to interact formally with some selected businesses to investigate and help with their evaluation problems (e.g. Publishing, Banking, Communications).The results of our work will be exploited by increased interaction between our group and HCI, CBR, DBMS and AI, members from those disciplines will be invited to participate in our workshops. Moreover, we will increase our interaction with industry involved with multimedia IR applications. Man