U.S. Route 33 (US 33) is a part of the U.S. Highway System that runs from Elkhart, Indiana to Richmond, Virginia.
 In Virginia, the U.S. Highway runs 135.60 mi from the West Virginia state line near Rawley Springs east to its eastern terminus at SR 33 in Richmond.
 US 33 is the primary east–west highway of Rockingham County, which lies in the Shenandoah Valley.
 The highway connects the independent city of Harrisonburg (which also serves as the seat of Rockingham County), the town of Elkton, and an entrance to Shenandoah National Park.
 East of the Blue Ridge Mountains, US 33 connects the Piedmont communities of Stanardsville, Gordonsville, and Louisa.
 The U.S. Highway is a major suburban and urban route in the Richmond metropolitan area.
 Within Richmond, US 33 runs concurrently with US 250.
 SR 33 continues from US 33's eastern terminus as a state-numbered extension of the U.S. Highway that connects Richmond with Virginia's Middle Peninsula.
South Carolina Highway 263 (SC 263) is a 5.3 mi state highway in the U.S. state of South Carolina.
 The highway connects Eastover with rural areas of Richland County.
Mansfield is a city in and the county seat of Richland County, Ohio, United States.
 Located midway between Columbus and Cleveland via Interstate 71, it is part of Northeast Ohio and North-central Ohio regions in the western foothills of the Allegheny Plateau, approximately 65 mi northeast of Columbus, 65 mi southwest of Cleveland and 91 mi southeast of Toledo.
 Richland County is part of the 18-county Northeast Ohio region.
Wahpeton ( ) is a city in Richland County, in southeastern North Dakota, United States.
 It is located along the Bois de Sioux River at its confluence with the Otter Tail River, forming the Red River of the North.
 Wahpeton is the county seat of Richland County.
 The U.S. Census Bureau estimated the city's 2015 population was 7,899.
U.S. Route 221 (US 221) is a part of the U.S. Highway System that runs from Perry, Florida to Lynchburg, Virginia.
 In Virginia, the U.S. Highway runs 149.61 mi from the North Carolina state line near Independence north to its northern terminus at US 29 Business, US 460 Business, and US 501 Business in Lynchburg.
 US 221 connects Independence, Galax, and Hillsville in Southwest Virginia while running concurrently with US 58.
 The U.S. Highway connects those communities with Roanoke via Floyd County, within which US 221 is the main east–west highway.
 The U.S. Highway also runs concurrently with US 460 from Roanoke to Bedford and parallels that U.S. Highway from Bedford to Lynchburg.
Columbia is the capital and second largest city of the U.S. state of South Carolina, with a population estimate of 134,309 as of 2016.
 The city serves as the county seat of Richland County, and a portion of the city extends into neighboring Lexington County.
 It is the center of the Columbia metropolitan statistical area, which had a population of 767,598 as of the 2010 United States Census, growing to 817,488 by July 1, 2016, according to 2015 U.S. Census estimates.
 The name "Columbia" is a poetic term used for the United States, originating from the name of Christopher Columbus.
South Carolina Highway 764 (SC 764) is a 8.9 mi state highway in the U.S. state of South Carolina.
 The highway connects rural areas of Richland County with Eastover.
U.S. Route 76 (US 76) is an east–west U.S. highway in the U.S. state of South Carolina.
 Being one of the longest highways in the state, it connects the cities of Anderson, Columbia, Sumter and Florence.
Richland County is a county in the U.S. state of Wisconsin.
 As of the 2010 census, the population was 18,021.
 Its county seat is Richland Center.
 The county was created from the Wisconsin Territory in 1842 and organized in 1850.
 It is named for the high quality of its soil.
 Some rural areas in the county have their power provided by the Richland Electric Cooperative.
Olney ( ) is a city in Richland County, Illinois, United States.
 The population was 8,631 at the 2000 census.
 It is the county seat of Richland County.

Question: In what direction does the U.S. highway that connects Florence, Souther Carolina and the county seat of Richland County run?
Answer: east–west