Los Angeles ( ; Spanish for "The Angels"; ] ), officially the City of Los Angeles and often known by its initials L.A., is the cultural, financial, and commercial center of Southern California.
 With a U.S. Census-estimated 2016 population of 3,976,322, it is the second most populous city in the United States (after New York City) and the most populous city in the state of California.
 Located in a large coastal basin surrounded on three sides by mountains reaching up to and over 10000 ft , Los Angeles covers an area of about 469 sqmi .
 The city is also the seat of Los Angeles County, the most populated county in the country.
 Los Angeles is the center of the Los Angeles metropolitan area, with 13,131,431 residents, and is part of the larger designated Los Angeles-Long Beach combined statistical area (CSA), the second most populous in the nation with a 2015 estimated population of 18.7 million.
"420" is the 12th episode in the seventh season of the American animated television series "Family Guy".
 It premiered on Fox in the United States on April 19, 2009.
 The title of the episode is a reference to the term "420" used in cannabis culture; "420" premiered the day before April 20 (4/20), on which a counterculture holiday is celebrated centering on the consumption of cannabis.
 "420" focuses on the character Brian after he is arrested for drug possession, which prompts him to launch a campaign to legalize cannabis with help from Stewie; the liveliness of their campaign convinces Mayor West to legalize the drug, and most of Quahog's population begins using it.
The city's population was estimated to be 320,434 in 2014, making it the eighth-most populous city in Texas.
 The Corpus Christi metropolitan area had an estimated population of 442,600.
 It is also the hub of the six-county Corpus Christi-Kingsville-Alice Combined Statistical Area, with a 2013 estimated population of 516,793.
 The Port of Corpus Christi is the fifth-largest in the United States.
 The region is served by the Corpus Christi International Airport.
Bowling Green is a home rule-class city in and the county seat of Warren County, Kentucky, United States.
 As of 2016, its population of 65,234 made it the third most-populous city in the state after Louisville and Lexington; its metropolitan area had an estimated population of 165,732; and the combined statistical area it shares with Glasgow has an estimated population of 218,870.
Fort Wayne is a city in the U.S. state of Indiana and the seat of Allen County.
 Located in northeastern Indiana, the city is 18 mi west of the Ohio border and 50 mi south of the Michigan border.
 With an estimated population of 264,488 in 2016, Fort Wayne is the 77th most populous city in the United States and the second largest in Indiana, after Indianapolis.
 It is the principal city of the Fort Wayne metropolitan area, consisting of Allen, Wells, and Whitley counties, a combined population of 419,453 as of 2011.
 In addition to the three core counties, the combined statistical area (CSA) includes Adams, DeKalb, Huntington, Noble, and Steuben counties, with an estimated population of 615,077.
Bartow ( ) is the county seat of Polk County, Florida, United States.
 Founded in 1851 as Fort Blount, the city was renamed in honor of Francis S. Bartow, the first brigade commander to die in combat during the American Civil War.
 According to the U.S. Census Bureau 2000 Census, the city had a population of 15,340 and an estimated population of 16,959 in 2009.
 It is part of the Lakeland−Winter Haven Metropolitan Statistical Area, which had an estimated population of 584,383 in 2009.
 As of 2016, the mayor of Bartow is Trish Pfeiffer.
Legalize LA was an activist campaign promoting amnesty for illegal immigrants, propagated through billboards, protests, clothing, advertisements, educational pamphlets, and grass roots support, underwritten by American Apparel.
 Originating locally in Downtown Los Angeles, the company took the campaign national in early 2008.
Amarillo ( ) is the 14th-most populous city in the state of Texas, in the United States.
 It is also the largest city in the Texas Panhandle, and the seat of Potter County.
 A portion of the city extends into Randall County.
 The estimated population was 199,582 as of 2016.
 The Amarillo metropolitan area has an estimated population of 276,020 in four counties as of 2017.
Charleston is the oldest and largest city in the U.S. state of South Carolina, the county seat of Charleston County, and the principal city in the Charleston–North Charleston–Summerville Metropolitan Statistical Area.
 The city lies just south of the geographical midpoint of South Carolina's coastline and is located on Charleston Harbor, an inlet of the Atlantic Ocean formed by the confluence of the Ashley and Cooper rivers.
 Charleston had an estimated population of 134,385 in 2016.
 The estimated population of the Charleston metropolitan area, comprising Berkeley, Charleston, and Dorchester counties, was 761,155 residents in 2016, the third-largest in the state and the 78th-largest metropolitan statistical area in the United States.
Milwaukee ( , ) is the largest city in the state of Wisconsin and the fifth-largest city in the Midwestern United States.
 The county seat of Milwaukee County, it is on Lake Michigan's western shore.
 Ranked by estimated 2014 population, Milwaukee was the 31st largest city in the United States.
 The city's estimated population in 2015 was 600,155.
 Milwaukee is the main cultural and economic center of the Milwaukee metropolitan area.
 It is also part of the larger Milwaukee-Racine-Waukesha combined statistical area, which had an estimated population of 2,026,243 in the 2010 census.

Question: Legalize LA was a campaign that centered on a city what an estimated population of what in 2016?
Answer: 3,976,322