Rafael Cedeño Hernández is an imprisoned Mexican drug trafficker who was a high-level leader of La Familia Michoacana, a drug cartel based in the Mexican state of Michoacán.
 He was the successor of Alberto Espinoza Barrón, a drug trafficker who was arrested on 31 December 2008 by the Mexican authorities.
Frank Lucas (born September 9, 1930) is an American former drug trafficker, who operated in Harlem during the late 1960s and early 1970s.
 He was particularly known for cutting out middlemen in the drug trade and buying heroin directly from his source in the Golden Triangle.
 Lucas boasted that he smuggled heroin using the coffins of dead American servicemen, but this claim is denied by his South East Asian associate, Leslie "Ike" Atkinson.
 Rather than hide the drugs in the coffins, they were hidden in the pallets underneath as depicted in the 2007 feature film "American Gangster" in which he was played by Denzel Washington, although the film fictionalized elements of Lucas' life for dramatic effect.
American Gangster is a 2007 American biographical crime film directed and produced by Ridley Scott and written by Steven Zaillian.
 The film is fictionally based on the criminal career of Frank Lucas, a gangster from La Grange, North Carolina who smuggled heroin into the United States on American service planes returning from the Vietnam War, before being detained by a task force led by detective Richie Roberts.
 The film stars Russell Crowe and Denzel Washington in their first lead acting roles together since 1995's "Virtuosity".
 The film also co-stars Ted Levine, John Ortiz, Josh Brolin, Chiwetel Ejiofor, Norman Reedus, Ruby Dee, Lymari Nadal and Cuba Gooding Jr.
Alejandro "Alex" Sosa is a fictional character and the main antagonist in the 1983 American crime film "Scarface" and the 2006 video game "".
 He is a Bolivian drug dealer and the chief supplier of cocaine for Tony Montana.
 Only when Sosa was felt betrayed did his relationship with Tony Montana end.
 Sosa is portrayed by Paul Shenar in the film and voiced by Robert Davi in the game.
 He is based on the Bolivian drug trafficker Roberto Suárez Goméz.
Joaquín Archivaldo Guzmán Loera (] ; born on 25 December 1954 or 4 April 1957) is a Mexican drug lord who headed the Sinaloa Cartel, a criminal organization named after the Mexican Pacific coast state of Sinaloa where it was formed.
 Known as "El Chapo" ("Shorty", ] ) for his 168 cm stature, he became Mexico's top drug kingpin in 2003 after the arrest of his rival Osiel Cárdenas Guillén of the Gulf Cartel, and was considered the "most powerful drug trafficker in the world" by the United States Department of the Treasury.
Juan Carlos Ramírez Abadía (Alias "Chupeta") (born February 16, 1963 in Palmira, Colombia) is a drug trafficker who, until his capture, was one of the leaders of the North Valley Cartel (Norte del Valle Cartel), who was wanted on drug smuggling, murder and RICO charges in the United States of America.
 In addition to the trafficking of cocaine, it is believed Abadia also participated in money laundering and trafficking of heroin.
 Through Abadias' illegal enterprise, he has amassed a fortune estimated at $1.8 billion by the US Department of State.
 He has been cited as "... one of the most powerful and most elusive drug traffickers in Colombia" by Adam J. Szubin, Director of the U.S. Department of the Treasury's Office of Foreign Assets Control (OFAC).
Héctor Manuel Sauceda Gamboa (died 17 February 2009), commonly referred to by his alias El Karis, was an alleged drug trafficker and high-ranking leader of the Gulf Cartel (Spanish: "Cártel del Golfo"), a Mexican drug trafficking organization.
 He was the brother of the drug lord Gregorio Sauceda Gamboa, another high-ranking drug trafficker who worked under the tutelage of Osiel Cárdenas Guillén, the former top leader of the cartel.
Figueroa Agosto (born June 28, 1964), also known as "José David Figueroa Agosto", "Junior Capsula" and "the Pablo Escobar of the Caribbean", is a Puerto Rican drug trafficker.
 As the head of a major drug trafficking organization that made 90% of cocaine in Puerto Rico, Figueroa Agosto is considered to be one of the most dangerous drug lords of Puerto Rico.
 He was the most wanted fugitive in Puerto Rico and the Dominican Republic.
Rafael Caro Quintero (born October 3, 1952) is a Mexican drug trafficker who founded the now-disintegrated Guadalajara Cartel with Miguel Ángel Félix Gallardo and other drug traffickers in the 1970s.
 He is the brother of fellow drug trafficker Miguel Caro Quintero, the founder and former leader of the extinct Sonora Cartel who remains incarcerated.
Bhupinder "Bindy" Singh Johal (January 14, 1971 – December 20, 1998) was an Indian born gangster who was raised in, and operated in, British Columbia, Canada.
 A self-confessed drug trafficker; he was known for his outspoken nature and blatant disregard for authority.
 His quote ".
.
I'm still around" has been sensationalized by Canadian pop-culture.
 On December 20, 1998, he was killed from behind at a crowded nightclub in Vancouver, British Columbia.

Question: American Gangster is fictionally based on the career of which Harlem-based drug trafficker?
Answer: Frank Lucas