El Fuerte de Samaipata or Fort Samaipata, also known simply as "El Fuerte", is a Pre-Columbian archaeological site and UNESCO World Heritage Site located in Florida Province, Santa Cruz Department, Bolivia.
 It is situated in the eastern foothills of the Bolivian Andes and is a popular tourist destination for Bolivians and foreigners alike.
 It is served by the nearby town of Samaipata.
 The archaeological site at El Fuerte is unique as it encompasses buildings of three different cultures: Chanè, Inca, and Spanish.
The Reedy Creek Site (44HA22) is a pre-Columbian archaeological site located in Halifax County, Virginia, near the town of South Boston.
 The site was first inhabited in the Late Archaic period from 2000 to 1000 B.C. Later, from 900 to 1400 A.D., a village was located at the site.
 Archaeological excavations at the site have revealed animal bones and seed and nut remnants, providing evidence as to the diet of the region's native inhabitants.
El Palmillo is a Mesoamerican Classic Period archaeological site located in the Valley of Oaxaca, associated with the pre-Columbian Zapotec civilization which was centered in the valley and the surrounding highlands of the present-day state of Oaxaca, Mexico.
 Located on a hilltop in the eastern Tlacolula arm of the valley, El Palmillo is just to the south of the pre-Columbian site of Mitla and to the east of the major Zapotec regional center, Monte Albán.
San José Mogote is a pre-Columbian archaeological site of the Zapotec, a Mesoamerican culture that flourished in the region of what is now the Mexican state of Oaxaca.
 A forerunner to the better-known Zapotec site of Monte Albán, San José Mogote was the largest and most important settlement in the Valley of Oaxaca during the Early and Middle Formative periods (ca. 1500-500 BCE) of Mesoamerican cultural development.
Aguazuque is a pre-Columbian archaeological site located in the western part of the municipality Soacha, close to the municipalities Mosquera and San Antonio del Tequendama in Cundinamarca, Colombia.
 It exists of evidences of human settlement of hunter-gatherers and in the ultimate phase primitive farmers.
 The site is situated on the Bogotá savanna, the relatively flat highland of the Altiplano Cundiboyacense close to the present-day course of the Bogotá River at an altitude of 2600 m above sea level.
 Aguazuque is just north of another Andean preceramic archaeological site; the rock shelter Tequendama and a few kilometres south of Lake Herrera.
 The artefacts found mostly belong to the preceramic period, and have been dated to 5025 to 2725 BP (3000 to 700 BCE).
 Thus, the younger finds also pertain to the later ceramic Herrera Period.
 There were some difficulties in dating of the uppermost layer due to modern agricultural activity in the area; the sediments of the shallower parts were disturbed.
Guaytán is an archaeological site of the Maya civilization in the municipality of San Agustín Acasaguastlán, in the department of El Progreso, in Guatemala.
 It is the most important pre-Columbian archaeological site of the middle drainage of the Motagua River.
Monte Albán, likely originally called Danipaguache (Zapotec for sacred mountain of life), is a large pre-Columbian archaeological site in the Santa Cruz Xoxocotlán Municipality in the southern Mexican state of Oaxaca (17.043° N, 96.767°W).
 The site is located on a low mountainous range rising above the plain in the central section of the Valley of Oaxaca where the latter's northern Etla, eastern Tlacolula, and southern Zimatlán & Ocotlán (or Valle Grande) branches meet.
 The present-day state capital Oaxaca City is located approximately 9 km east of Monte Albán.
The Mitchell Archaeological Site is a pre-Columbian archaeological site located at the western end of University Drive in Mitchell, Illinois.
 The site includes a platform mound and the remains of a village; while it once included several other mounds, they have been destroyed by modern activity.
 Mississippian peoples inhabited the site c. 1150-1200.
 The site is affiliated with the Cahokia settlement system and was the largest site in the system except for Cahokia itself.
 However, the majority of the site was destroyed by the construction of Interstate 270; known information about the site mainly comes from salvage excavations conducted before the highway was built.
Izapa is a very large pre-Columbian archaeological site located in the Mexican state of Chiapas; it is best known for its occupation during the Late Formative period.
 The site is situated on the Izapa River, a tributary of the Suchiate River, near the base of the Tacaná volcano, the sixth tallest mountain in Mexico.
The Golden Eagle-Toppmeyer Site is a pre-Columbian archaeological site located near the confluence of the Illinois and Mississippi Rivers in Calhoun County, Illinois.
 The site is associated with the Havana Hopewell culture and has two main components: the Golden Eagle earthwork and the Toppmeyer habitation site.
 The earthwork, which dates from the Middle Woodland period (150 BC - 450 AD), is the only geometric earthwork from the period in the central Mississippi River valley.
 Two mounds are incorporated in the rounded earthwork; one is located at the center, and one is located at a gap which has been called the "entrance" to the earthwork.
 The Toppmeyer habitation site, which overlaps the western edge of the earthwork, dates from the Late Woodland period (750 AD).
 The overall site was likely a regional transaction center at which extensive trade and cultural exchange among Hopewell people in the Illinois River valley took place.

Question: Which large pre-Columbian archaeological site is the major Zapotec regional center?
Answer: Monte Albán