Nikolas Cassadine is a fictional character from "General Hospital", an American soap opera on the ABC network.
 Originated by actor Tyler Christopher in 1996, he left the show on July 14, 1999.
 Due to Nikolas' importance on the soap, he was immediately replaced by Coltin Scott on July 20, 1999.
 Scott left the role on April 16, 2003, as Christopher made his return on April 21, 2003.
 Christopher vacated the role on July 28, 2011, after he was let go from the series.
 Christopher once again reprised the role on a recurring basis in honor of the soaps' fiftieth anniversary; he was later upgraded to a series regular.
 Actor Nick Stabile took claim of the role in June 2016 in Christopher's absence.
 Created by head-writers Robert Guza, Jr. and Karen Harris and introduced by executive producer Wendy Riche in 1996 as the illegitimate son of Laura Spencer, the character was immediately popular with audiences.
 Hailed by "Soap Opera Digest" as the "Best New Male Character" in 1996, Nikolas's arrival immediately implodes the happy life of supercouple Luke and Laura.
Jaime Ray Newman (born April 2, 1978) is an American actress and singer.
 She is known for starring as Kristina Cassadine on the soap opera "General Hospital", Mindy O'Dell on the drama "Veronica Mars", Kat Gardener on the fantasy drama "Eastwick", Tess Fontana on the science-fiction drama "Eureka", Kat Petrova on the drama-thriller "Red Widow", Sam Gordon on the comedy-drama "Mind Games", Allison Roth on the crime drama "Wicked City", and Sarah Lieberman in "The Punisher".
The Witches of Eastwick is a 1987 American comedy-fantasy film based on John Updike's novel "The Witches of Eastwick".
 Directed by George Miller, the film stars Jack Nicholson as Daryl Van Horne, alongside Cher, Michelle Pfeiffer and Susan Sarandon as the eponymous witches.
Valentin Cassadine is a fictional character from "General Hospital", an American soap opera on the ABC network.
 The character was initially conceived in 2009 by head writer Robert Guza, Jr., as a previously unknown member of the wealthy Cassadine family, looking to wreak havoc on both the Cassadine and Spencer families.
 However, initial plans for the character's introduction were delayed and completely abandoned by 2010.
 In 2016, it was announced that "All My Children" alumni James Patrick Stuart had joined the cast in the mystery role of Theo — who is revealed to be Valentin.
 Valentin is known for being the most evil of the Cassadine sons having been disowned by his father at a very young age.
 At one point, he even poisons his stepmother Helena (Constance Towers) when she tries to reach out to him for her own personal agenda.
The Witches Of Chiswick is a novel by the British author Robert Rankin, the title parodying that of "The Witches of Eastwick" by John Updike.
Roger Howarth (born September 13, 1968) is an American actor.
 He played character Todd Manning on the daytime drama "One Life to Live" ("OLTL"); the character earned Howarth a Daytime Emmy Award in 1994, and is cited as an icon in the soap opera genre.
 He left the series in 2003 and joined soap opera "As the World Turns", where he played the character of Paul Ryan until the series final episode in 2010.
 Howarth returned to "OLTL" in May 2011, eventually deciding to continue the role on "General Hospital" in March 2012.
 He now portrays Franco on "General Hospital," the character formerly created and portrayed by James Franco.
 In addition to his soap opera work, Howarth has guest starred in television shows such as "Prey" and "Dawson's Creek".
The Widows of Eastwick is the final novel by John Updike, author of the Pulitzer-prize winning "Rabbit" series.
 First published in 2008, it is a sequel to his novel "The Witches of Eastwick".
John Dempsey is an American theatrical lyricist and playwright who has worked in Britain and the United States.
 His work has been produced in Japan, Brazil and other countries.
 Much of his work in musical theater has been written with composer Dana P. Rowe.
 With Rowe, he wrote the book and lyrics for "Zombie Prom" (1995), "The Fix" (directed by Sam Mendes, 1997), and the stage adaptation of John Updike's "The Witches of Eastwick" (2000).
 Rowe and Dempsey were nominated for the Olivier Award for "The Fix" and "The Witches of Eastwick", both of which were produced in London by Cameron Mackintosh ("Cats", "Phantom of the Opera", "Les Miserables").
 He was the co-lyricist for "The Pirate Queen", collaborating with composer Claude-Michel Schönberg and lyricist Alain Boublil ("Les Miserables").
Eastwick is an American fantasy comedy-drama television series based on John Updike's novel "The Witches of Eastwick" which aired on ABC from September 23 until December 30, 2009.
 The series was developed by Maggie Friedman, and starred Paul Gross as the infamous Darryl Van Horne, alongside Jaime Ray Newman, Lindsay Price, and Rebecca Romijn as the eponymous witches.
The Cassadines are a fictional aristocratic family from the American soap opera "General Hospital".
 Created by executive producer Gloria Monty, the family was first introduced in August 1981, with the arrival of brothers Mikkos, Victor, and Tony Cassadine.
 The Cassadines are descendants of Russian royalty and own their own private island in Greece.
 Various family members have been sometime residents of Port Charles, living in Wyndemere Castle on Spoon Island.
 The family is known for their longtime feud with the Spencer family.
 After the family's initial appearance in 1981, they were absent from the series until the arrival of Stavros Cassadine in 1983.
 The Cassadine family owns and operates the international conglomerate Cassadine Industries.
 The family is currently represented on canvas by Alexis, Valentin, Sam, Kristina, Molly, Danny, Charlotte and Emily.

Question: What  American fantasy comedy-drama television series based on John Updike's novel "The Witches of Eastwick", starred an American actress known for starring as Kristina Cassadine on the soap opera "General Hospital"?
Answer: Eastwick