The Chesapeake and Ohio Canal, abbreviated as the C&O Canal and occasionally called the "Grand Old Ditch," operated from 1831 until 1924 along the Potomac River from Washington, D.C., to Cumberland, Maryland.
 The canal's principal cargo was coal from the Allegheny Mountains.
Annington is a historic home located at Poolesville, Montgomery County, Maryland, United States.
 The house is constructed of brick, Flemish bond, consisting of three two-story sections: a main block three bays wide, a wing to the west two bays wide, and a wing to the east three bays wide.
 The house was built during the wheat boom of the early 1810s that the western counties of Maryland and nearby Virginia experienced with the opening of the Chesapeake and Ohio Canal.
 The Georgian house was built in about 1813, for Daniel Trundle, a planter, and member of the Maryland State Legislature for ten years.
 The site is a commanding one, overlooking the Potomac River, and during the American Civil War was a strategic lookout point and occupied by Union officers.
Symphyotrichum oblongifolium, the aromatic aster, is a species of "Aster" native to parts of eastern and central United States.
 It is found in parts of Kansas,Ohio, northern Illinois, hilly parts of southern Illinois, and on the banks of the Mississippi River and Illinois River, as well as other parts of the central United States, for example, in Missouri and other places including along the Ohio River, from Pennsylvania to Nebraska to Minnesota to Virginia.
 It is an uncommon herbaceous perennial.
Obetz is a village in Franklin County, Ohio, United States.
 The population was 4,532 at the 2010 census.
 The community (originally "Obetz Junction", in honor of settler Charles Obetz) was formed in 1838 as a stagecoach junction, and incorporated in 1928.
 Nearby "Reese Station" served as the railroad station for the immediate area, while other adjacent communities such as Groveport, Lockbourne and Canal Winchester were part of the Ohio and Erie Canal canal and lock system.
 The close proximity of Obetz Junction to these terminal towns transformed the area into a hub of commerce, travel and trade in mid-19th century.
 Communities such as Obetz and its neighbors, with their strong ties to transportation helped to further cement Central and Columbus, Ohio's status as the state capital.
Ohiopyle is a borough in Fayette County, Pennsylvania, United States.
 The population was 59 at the 2010 census.
 While Ohiopyle has a tiny year-round population, it is often filled with tourists on the weekend, who come for the outdoor recreation opportunities at the surrounding Ohiopyle State Park, as well as the Great Allegheny Passage bicycle trail which connects with the Chesapeake and Ohio Canal towpath trail to form a continuous 335-mile off-road trail from Pittsburgh, Pennsylvania to Washington, D.C.
 The borough of Ohiopyle is served by the Uniontown Area School District.
The Loup Canal is a hydroelectric and irrigation canal located in eastern Nebraska, United States.
 The canal is owned and managed by Loup Power District, a public power electric utility.
Williamsport Historic District is a national historic district at Williamsport, Washington County, Maryland, United States.
 The district consists of the historic core of this town.
 Almost 20 percent of the buildings in the district date from the late 18th and early 19th centuries.
 They are generally of log or brick construction until the second quarter of the 19th century.
 The town grew with the Chesapeake and Ohio Canal and railroads, which resulted in prominent late 19th century Italianate and Queen Anne style buildings for residential and commercial purposes.
 Slightly less than 60 percent of the buildings date from the late 19th and early 20th centuries.
The Locks on the Chesapeake and Ohio Canal, located in Maryland, West Virginia, and Washington, D.C. of the United States, were of three types: lift locks; river locks; and guard, or inlet, locks.
Maryland Route 213 (MD 213) is a 68.25 mi state highway located on the Eastern Shore of Maryland in the United States.
 The route runs from MD 662 in Wye Mills, Queen Anne's County north to the Pennsylvania border in Cecil County, where it continues into that state as Pennsylvania Route 841 (PA 841).
 The route, which is a two-lane undivided highway its entire length, passes through mostly rural areas as well as the communities of Centreville, Chestertown, Galena, Cecilton, Chesapeake City, and Elkton.
 MD 213 intersects many routes including U.S. Route 50 (US 50) near Wye Mills, US 301 near Centreville, and US 40 in Elkton.
 It crosses over the Chesapeake and Delaware Canal in Chesapeake City on the Chesapeake City Bridge.
 MD 213 is designated by the state as the Chesapeake Country Scenic Byway between the southern terminus and Chesapeake City with the portion north of MD 18 in Centreville a National Scenic Byway.
 In addition, the route is also considered part of the Atlantic to Appalachians Scenic Byway between Chesapeake City and MD 273 in Fair Hill.
The Blue Ridge Tunnel (also known as the Crozet Tunnel) is a historic railroad tunnel built during the construction of the Blue Ridge Railroad in the 1850s.
 The tunnel was the westernmost and longest of four tunnels engineered by Claudius Crozet to cross the Blue Ridge Mountains at Rockfish Gap in central Virginia.
 At 4237 ft in length, the tunnel was the longest tunnel in the United States at the time of its completion in 1858.
 The tunnel was used by the Virginia Central Railroad from its opening to 1868, when the line was reorganized as the Chesapeake and Ohio Railroad (renamed Chesapeake and Ohio Railway in 1878).
 The Chesapeake and Ohio routed trains through the tunnel until it was abandoned and replaced by a new tunnel in 1944.
 The new tunnel was named the "Blue Ridge Tunnel" as well, although the original tunnel still remains abandoned nearby.
 The old Blue Ridge Tunnel has since been named a Historic Civil Engineering Landmark.

Question: Are the Chesapeake and Ohio Canal and Loup Canal both located in the central United States?
Answer: no