Yangtze River Pharmaceutical Group (, YRPG) is a Chinese multinational pharmaceutical corporation headquartered in Taizhou, Jiangsu Province in the People's Republic of China, and with its research headquarters in Shanghai.
 It is one of the Asia's largest pharmaceutical companies by revenues, and was listed in 2014 as being China's second largest pharmaceutical manufacturer, and leading company for technological and entrepreneurial innovation.
OSI Pharmaceuticals, Inc. is an American pharmaceutical company based in Long Island, New York with facilities in Colorado, New Jersey and the United Kingdom.
 OSI specializes in the discovery and development of molecular targeted therapies.
 Though oncology is the top priority for OSI, research and development targeting type 2 diabetes and obesity is conducted through their U.K. subsidiary Prosidion Limited.
 OSI has also made a foray into the ophthalmology market through a marketing agreement with Pfizer over Macugen (Pegaptanib) for Age-related macular degeneration; however, acquisition of the firm Eyetech, meant to provide control over this product and diversify the company, has been unsuccessful, ending in divestiture.
Bristol-Myers Squibb, often referred to as BMS, is an American pharmaceutical company, headquartered in New York City.
Pfizer Inc. is an American pharmaceutical corporation headquartered in New York City, with its research headquarters in Groton, Connecticut.
ImClone Systems Incorporated is a formerly independent biopharmaceutical company dedicated to developing biologic medicines in the area of oncology.
 It was founded in 1984 and has its corporate headquarters in Bridgewater, New Jersey and its research headquarters in New York City.
 On October 6, 2008, it accepted a $6.5 billion acquisition offer from Eli Lilly and Company, and became a fully owned subsidiary of Eli Lilly and Company on November 24, 2008.
 Prior to the acquisition, it was traded on the NASDAQ stock exchange under the symbol IMCL.
 In 2014 the use of the ImClone brand name was retired and the former ImClone research and manufacturing sites were renamed "Eli Lilly and Company".
Forest Laboratories was an American pharmaceutical company headquartered in New York City.
 Forest Laboratories was known for licensing European pharmaceuticals for sale in the United States.
 The company had offices in St. Louis, Cincinnati, Jersey City, Oakland, Dublin, Kent and Paris.
Help Remedies, Inc. is an American pharmaceutical company, founded by Richard Fine and Nathan Frank in 2008, based in New York City that sells an assortment of single-ingredient over-the-counter medications.
 The company has been noted for its unique product packaging and design ethic.
 All products are packaged in a flat, white, textured box that opens like a tin.
Clorets is a line of chewing gum and mints made by Cadbury Adams.
 It was introduced in 1951.
 Clorets gum and candy generally contains Actizol, a proprietary ingredient that contains chlorophyll, which purportedly acts as an active ingredient to eliminate mouth odors.
 Clorets was originally owned by The Warner-Lambert Company under its Adams division until Pfizer took over in 2000.
 The Adams division was sold to Cadbury-Schweppes in 2003, which is now known as Cadbury Adams (later acquired by Kraft Foods).
Fuller Potter (April 24, 1910 – 1990) was an American Abstract expressionist artist.
 He was born in New York City in 1910, attended St. Bernard's School in New York and Groton School in Groton, Massachusetts, and lived most of his life in his Ledyard, Connecticut estate, near Old Mystic.
 Potter started painting in the traditional modes of representation, specializing in still life and landscape.
 His work was shown in New York in the 1930s at the Marie Harriman Gallery.
Alexion Pharmaceuticals Inc. is an American pharmaceutical company best known for its development of Soliris, a drug used to treat the rare disorders atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH).
 The company is also involved in immune system research related to autoimmune diseases.
 It employs around 2,400 people worldwide.
 In February 2016, the company held the dedication ceremony for its new headquarters in New Haven, Connecticut, not far from the company's starting point in the same city.

Question: When was the American pharmaceutical corporation headquartered in New York City, with its research headquarters in Groton, Connecticut took over Clorets?
Answer: 2000