Psi Factor presenter Dan Aykroyd
Plot
The series was hosted by Dan Aykroyd, who presents dramatic stories inspired by the paranormal investigations of the "Office of Scientific Investigation and Research" (O.S.I.R.).Dan Aykroyd as The Host
Paul Miller as Case Manager Professor Conner Doyle (Season 1, guest star Season 4)
Nancy Anne Sakovich as Senior Data Analyst Lindsay Donner
Barclay Hope as Physicist Peter Axon
Colin Fox as Dr. Anton Hendricks
Maurice Dean Wint as Case Manager Dr. Curtis Rollins (Season 1, recurring Season 2–3)
Matt Frewer as Case Manager Matt Praeger (Season 2–4)
Nigel Bennett as Director of Operations Frank Elsinger (Season 3, recurring Season 1–2)
Peter MacNeill as Security Co-ordinator Ray Donahue (Season 3, recurring Season 1–2)
Joanne Vannicola as Dr. Mia Stone (Season 4)
Soo Garay as Dr. Claire Davison (Season 4, recurring Season 1–3)
host anchor emcee moderator facilitator