Philip II of Spain relative Maria Manuela, Princess of Portugal
First marriage
Philip's first wife was his double first cousin, Maria Manuela, Princess of Portugal. She was a daughter of Philip's maternal uncle, John III of Portugal, and paternal aunt, Catherine of Austria. They were married at Salamanca on 12 November 1543. The marriage produced one son in 1545, after which Maria died four days later due to haemorrhage:
kin family member kinsman kinswoman relation by marriage