Home on the Range performer Frank Sinatra
Modern usage
Bing Crosby recorded the song again in 1938 and 1939. Frank Sinatra also recorded the song on March 10, 1946 and his version was released in Great Britain but was not available in the United States until 1993. Others who have recorded the song include John Charles Thomas, Connie Francis, Gene Autry, Boxcar Willie, Burl Ives, Pete Seeger, Johnnie Ray, Slim Whitman, Steve Lawrence and Tori Amos. "Home on the Range" is often performed in programs and concerts of American patriotic music and is frequently used in plays and films. The song is also the theme opening music for the early Western films starring Ray "Crash" Corrigan and his two co-stars in their movie roles as "The Three Mesqueteers".
It is also featured in the 1937 screwball comedy The Awful Truth (sung by Irene Dunne and Ralph Bellamy), the 1948 film Mr. Blandings Builds His Dream House (sung by both Cary Grant and Myrna Loy), the 1967 off-Broadway musical You're a Good Man, Charlie Brown (sung by the cast as a glee club rehearsal number), the 1980 film Where the Buffalo Roam (sung by Neil Young over the opening credits), the 2009 film The Messenger (sung by Willie Nelson over the closing credits), and the 1946 western film Colorado Serenade (sung by actor Roscoe Ates). Actor Harry Dean Stanton (as the angel "Gideon") sings an excerpt from his mid-tree perch in the 1985 film One Magic Christmas. A parody version is sung by villain Percival McLeach in the 1990 animated film The Rescuers Down Under.
The song has made its way into screen shorts for children and adults, as in the 1954 Looney Tunes cartoon Claws for Alarm, where it is sung by Porky Pig. Likewise, Bugs Bunny sings the song in both The Fair-Haired Hare (1951) and Oily Hare (1952), the latter containing original lyrics specific to Texas oilmen.
The song is used in The Simpsons episode "Lisa's Substitute" (1991) in which Lisa is inspired by a substitute teacher who dresses as a cowboy and sings the song with commentary. It was also used on the Shining Time Station episode "A Dog's Life."It made an appearance on GLOW when Debbie Eagan (played by Betty Gilpin) sang a portion in the fourth episode of the second season.Vikingarna recorded an instrumental version of the song on the 1981 album Kramgoa låtar 9 , entitled "Home on the Ranch".An instrumental version of the song was used in the 2011 video game, Rage.
In 2016, the American progressive rock  band Kansas released a version of the song as a bonus track on their album The Prelude Implicit.
In 2017, a docudrama was released that told the story of the song's origins and the lawsuit from the 1930s that finally concluded the authorship of the song. The film was produced by the People's Heartland Foundation and Lone Chimney Films and featured actors Buck Taylor, Rance Howard, Darby Hinton, and the voice of the Kansas City Chiefs, Mitch Holthus. The film also included music contributed by Kansas, Sons of the Pioneers, Michael Martin Murphey, and others. The film was directed by Ken Spurgeon and aired on regional PBS stations.