Caffeinism cause intoxication
muscle twitching,
rambling flow of thought and speech,
tachycardia and cardiac arrhythmia,
periods of inexhaustibility, and
psychomotor agitation,
anorexia (loss of appetite).The symptoms of caffeine intoxication are comparable to the symptoms of overdoses of other stimulants. In cases of much larger overdoses, mania, depression, lapses in judgment, disorientation, disinhibition, delusions, weight loss, loss of appetite, hallucinations, or psychosis may occur.Death can occur as a result of caffeine overdose. The LD50 of caffeine in humans is dependent on individual sensitivity, but is estimated to be 150–200 milligrams per kilogram of body mass (75–100 cups of coffee for a 70 kilogram adult). A number of fatalities have been caused by overdoses of readily available powdered caffeine supplements, for which the estimated lethal amount is less than a tablespoon. The lethal dose is lower in individuals whose ability to metabolize caffeine is impaired due to genetics or chronic liver disease. A death was reported in a man with liver cirrhosis who overdosed on caffeinated mints.