rabbits no relation allergy
Toxicity
Although there is no consensus on the level of lethal dose in humans after oral intake, it is assumed that the intake of 0.1 to 1 microgram per kilogram of body weight, or the consumption of a single seed of the rosary pea, may be fatal, but this information is not sufficiently documented. According to other estimates, the LD50 value of abrin is between 10 and 1000 μg/kg and is comparable to that of ricin. The severity of the effects of abrin poisoning vary on the means of exposure to the substance (whether inhaled, ingested, or injected). Exposure to abrin on the skin can cause an allergic reaction, indicated by blisters, redness, irritation, and pain, however, there is no evidence of toxicity after skin contact has been made.
Abrin is significantly more toxic following intravenous administration. The LD50 values obtained vary between 0.03 and 0.06 μg/kg in rabbits and between 1.25 and 1.3 μg/kg in dogs, depending on the species. In clinical studies involving cancer patients, up to 0.3 μg/kg intravenous of abrin immunotoxin was tolerated without the development of serious symptoms of toxicity.
The toxicity of abrin is also increased if it is inhaled. In rats, the LD50 for this route of administration is 3.3 μg/kg.
no relation