Ishiyama Hongan-ji War participant Oda Nobunaga
Siege
In August 1570, Oda Nobunaga left Gifu Castle in Gifu with 30,000 troops, and ordered his generals to build fortresses around Ishiyama, while Nobunaga himself focused on the Sieges of Nagashima fortress and other campaigns. 
On September 12, the Ikkō-ikki launched a midnight stealth attack against Nobunaga's forces at Kawaguchi and Takadono. The Ikko were reinforced by warrior monks from Negoro-ji in Kii Province and 3,000 musketeers, pushing Oda's army back. 
Nobunaga's armies remained camped out, assigned to monitor the Ikki's fortress, and take it if they could.
In 1574, after destroying the Nagashima complex and reducing the threat from the Ikki's supporters, Oda attempted to starve out the fortress. This was no easy task, however, because the Ishiyama fortress sat on the coast, which was guarded by the fleet of the Mōri clan, masters of naval combat and Oda's enemies.
By early 1575, however, the fortress was already in urgent need of supplies, and the Abbot Kōsa was ready to begin peaceful overtures with Nobunaga to end the siege. But the ousted shōgun Ashikaga Yoshiaki sent a letter to Mōri Terumoto asking for his aid in supplying the cathedral fortress.: 288–289  Yoshiaki eventually raised some troops himself to aid the besieged.Battle of Tennoji
In April 1576, Oda's army attacked the Hongan-ji fortress, led by Harada Naomasa, Akechi Mitsuhide, Hosokawa Fujitaka, Tsutsui Junkei, Nakagawa Kiyohide, Takayama Ukon, Araki Murashige, and Sakuma Nobuhide, but Oda forces were quickly repelled by 15,000 Ikkō-ikki defenders. Mitsuhide and Nobuhide made a request for reinforcements to Nobunaga who was staying in Kyōto. Later, Nobunaga himself personally came. He led an army of only 3,000 men to attack as many as 15,000 enemy forces, along with Niwa Nagahide, Hashiba Hideyoshi, Takigawa Kazumasu, Hachiya Yoritaka and Inaba Yoshimichi. Nobunaga attacked Mitsuji fortress, pushing back the Ikki garrison to their inner gates and Nobunaga suffered a bullet wound to his leg. However, Harada Naomasa lost his life during the battle.