Eocene significant event Eocene–Oligocene extinction event
Geology
Boundaries
The Eocene is a dynamic epoch that represents global climatic transitions between two climatic extremes, transitioning from the hot house to the cold house. The beginning of the Eocene is marked by the Paleocene–Eocene Thermal Maximum, a short period of intense warming and ocean acidification brought about by the release of carbon en masse into the atmosphere and ocean systems, which led to a mass extinction of 30–50% of benthic foraminifera–single-celled species which are used as bioindicators of the health of a marine ecosystem—one of the largest in the Cenozoic. This event happened around 55.8 mya, and was one of the most significant periods of global change during the Cenozoic.The middle Eocene was characterized by the shift towards a cooler climate at the end of the EECO, around 47.8 Ma, which was briefly interrupted by another warming event called the middle Eocene climatic optimum (MECO). Lasting for about 400, 000 years, the MECO was responsible for a globally uniform 4° to 6°C warming of both the surface and deep oceans, as inferred from foraminiferal stable oxygen isotope records. The resumption of a long-term gradual cooling trend resulted in a glacial maximum at the late Eocene/early Oligocene boundary. 
The end of the Eocene was also marked by the Eocene–Oligocene extinction event, also known as the Grande Coupure.