Tahmasp I child Maryam Begum
Sultanum Begum (c. 1516 – 1593 in Qazvin), Tahmasp's chief wife, from the Mawsillu tribe, mother of his two older sons
Sultan-Agha Khanum, a Circassian, sister of Shamkhal Sultan Cherkes (governor of Sakki), mother of Pari Khan Khanum and Suleiman Mirza
Sultanzada Khanum, a Georgian slave, mother of Haydar Mirza
Zahra Baji, a Georgian, mother of Mustafa Mirza and Ali Mirza
Huri Khan Khanum, a Georgian, mother of Zeynab Begum and Maryam Begum
A sister of Waraza Shalikashvili
Zaynab Sultan Khanum (m. 1549; died in Qazvin October 1570 and buried in Mashhad), widow of Tahmasp's younger brother Bahram MirzaHe had thirteen sons:Mohammad Khodabanda (1532 – 1595 or 1596), Shah of Iran (r. 1578–1587)
Ismail II (31 May 1537 – 24 November 1577), Shah of Iran (r. 1576–77)
Murad Mirza (d. 1545), nominal governor of Kandahar; died in infancy
Suleiman Mirza (d. 9 November 1576), Governor of Shiraz, killed during Ismail II's purge
Haydar Mirza (28 September 1556 – 9 November 1576), self-proclaimed Shah of Iran for a day after Tahmasp's death; killed by his guards in Qazvin
Mustafa Mirza, (d. 9 November 1576), killed during Ismail II's purge; his daughter married Abbas the Great
Junayd Mirza (d. 1577), killed during Ismail II's purge
Mahmud Mirza (d. 7 March 1577), governor of Shirvan and Lahijan, killed during Ismail II's purge
Imam Qoli Mirza (died 7 March 1577), killed during Ismail II's purge
Ali Mirza (d. 31 January 1642), blinded and imprisoned by Abbas the Great
Ahmad Mirza (died 7 March 1577), killed during Ismail II's purge
Murad Mirza (d. 1577), killed during Ismail II's purge
Zayn al-Abedin Mirza, died in childhood
Musa Mirza, died in childhoodTahmasp probably had thirteen daughters, eight of whom are known:
Gawhar Sultan Begum (d. 1577), married Sultan Ibrahim Mirza
Pari Khan Khanum (d. 1578), died by the orders of Khayr al-Nisa Begum
Zeynab Begum (d. 31 May 1640), married Ali-Qoli Khan Shamlu
Maryam Begum (d. 1608), married Khan Ahmad Khan
Shahrbanu Khanum, married Salman Khan Ustajlu
Khadija Begum (d. after 1564), married Jamshid Khan (grandson of Amira Dabbaj, a local ruler in western Gilan)
Fatima Sultan Khanum (d. 1581), married Amir Khan Mawsillu
Khanish Begum, married Shah Nimtullah Amir Nizam al-Din Abd al-Baqi (leader of the Ni'matullāhī order)
offspring progeny issue descendant heir