Siege of Kamakura (1333) followed by Siege of Tōshō-ji
The 1333 siege of Kamakura was a battle of the Genkō War, and marked the end of the power of the Hōjō clan, which had dominated the regency of the Kamakura shogunate for over a century.  Forces loyal to Emperor Go-Daigo and led by Nitta Yoshisada entered the city from multiple directions and destroyed it; in the end, the Hōjō leaders retreated to Tōshō-ji, the Hōjō family temple, where they committed suicide with the rest of the clan.