Fra Angelico notable work San Marco Altarpiece
San Marco, Florence, 1436–1445
In 1436, Fra Angelico was one of a number of the friars from Fiesole who moved to the newly built convent or friary of San Marco in Florence. This was an important move which put him in the centre of artistic activity of the region and brought about the patronage of Cosimo de' Medici, one of the wealthiest and most powerful members of the city's governing authority (or "Signoria") and founder of the dynasty that would dominate Florentine politics for much of the Renaissance. Cosimo had a cell reserved for himself at the friary in order that he might retreat from the world. 
It was, according to Vasari, at Cosimo's urging that Fra Angelico set about the task of decorating the convent, including the magnificent fresco of the Chapter House, the often-reproduced Annunciation at the top of the stairs leading to the cells, the Maesta (or Coronation of the Madonna) with Saints (cell 9) and the many other devotional frescoes, of smaller format but remarkable luminous quality, depicting aspects of the Life of Christ that adorn the walls of each cell.In 1439 Fra Angelico completed one of his most famous works, the San Marco Altarpiece at Florence. The result was unusual for its time. Images of the enthroned Madonna and Child surrounded by saints were common, but they usually depicted a setting that was clearly heaven-like, in which saints and angels hovered about as divine presences rather than people. But in this instance, the saints stand squarely within the space, grouped in a natural way as if they were able to converse about the shared experience of witnessing the Virgin in glory. Paintings such as this, known as Sacred Conversations, were to become the major commissions of Giovanni Bellini, Perugino and Raphael.San Marco, Florence, 1436–1445
Altarpiece for chancel – Virgin with Saints Cosmas and Damian, attended by Saints Dominic, Peter, Francis, Mark, John Evangelist and Stephen. Cosmas and Damian were patrons of the Medici. The altarpiece was commissioned in 1438 by Cosimo de' Medici. It was removed and disassembled during the renovation of the convent church in the seventeenth century. Two of the nine predella panels remain at the convent; seven are in Washington, Munich, Dublin and Paris. Unexpectedly, in 2006 the last two missing panels, Dominican saints from the side panels, turned up in the estate of a modest collector in Oxfordshire, who had bought them in California in the 1960s.
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