Question: what episode does izzie learn she has cancer

title: Izzie Stevens
text: Izzie disapproves of George 's relationship and marriage to orthopedic resident Callie Torres ( Sara Ramirez ) . She and George sleep together , and attempt to keep their liaison a secret . George and resident Miranda Bailey ( Chandra Wilson ) are the only people aware that Izzie gave birth to a daughter at the age of sixteen ; ultimately the child was given up for adoption . He supports Izzie when her daughter Hannah ( Liv Hutchings ) , diagnosed with leukemia , arrives at Seattle Grace Hospital in need of a bone marrow transplant from Izzie . Izzie 's feelings for George grow , and she reveals that she has fallen in love with him . When Callie discovers George has been unfaithful , the two separate , and George and Izzie embark on a short - lived relationship , only to discover there is no real chemistry between them .