Question: when does izzie get cancer in grey's anatomy

title: Izzie Stevens
text: Izzie supports Alex when he discovers his new girlfriend has psychiatric problems , and convinces him to have her committed . She is also handed primary responsibility for the clinic , as Bailey cuts back on her responsibilities . Izzie and Alex go on to rekindle their relationship , though Izzie is concerned when she begins hallucinating Denny . She discovers she has metastatic melanoma ( Stage IV ) which has spread to her liver , skin , and brain , causing the hallucinations . Her survival chances are estimated at only 5 % . She is admitted to Seattle Grace as a patient , and Derek Shepherd ( Patrick Dempsey ) successfully removes a tumor from her brain . Izzie spends her time in the hospital planning Meredith and Derek 's wedding , but when her condition worsens and Derek discovers a second brain tumor , they give the ceremony to Izzie and Alex , who marry in front of all their friends . The procedure to remove the second tumor from Izzie 's brain causes her to lose her short - term memory , and although she soon regains it , she flatlines moments later . The fifth season ends with her friends ignoring her DNR order and attempting to resuscitate her , transposed with images of Izzie in an elevator encountering George , who has been in an accident and is also currently flatlining . Though George dies , Izzie is resuscitated and recovers enough to return to work . 

Answer: answer: Izzie is concerned when she begins hallucinating Denny and eventually, she discovers she has metastatic melanoma which has spread to her liver, skin, and brain, causing the hallucinations.  When her condition worsens, Derek discovers a second brain tumor.
answer: Izzie is concerned when she begins hallucinating Denny and eventually, she discovers she has metastatic melanoma which has spread to her liver, skin, and brain, causing the hallucinations.