Carl H. June

Carl H. June (born 1953) is an American immunologist and oncologist. He is currently the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine of the University of Pennsylvania. He is most well known for his research on T cell therapies for the treatment of several forms of cancers.
In 2020 he was elected to the American Philosophical Society.
Education and career
June graduated from the US Naval Academy in 1975 and earned his medical degree in from the Baylor College of Medicine in 1979. He spent his fourth year of medical school at the World Health Organization in Geneva, Switzerland, studying immunology and malaria with Dr. Paul Henri-Lambert, and completed clinical training in internal medicine and medical oncology from 1979 to 1983 at the National Naval Medical Center in Bethesda, Maryland. June conducted postdoctoral research in transplantation biology with E. Donnall Thomas and John Hansen at the Fred Hutchinson Cancer Center in Seattle from 1983 to 1986. After completing his training, he returned to Bethesda, where he founded the Immune Cell Biology Program at the Naval Medical Research Center and was head of the department of immunology from 1990 to 1995. He was also a professor of medicine and of cell and molecular biology at the Uniformed Services University for the Health Sciences. In 1999 June joined the University of Pennsylvania as a professor of molecular and cellular engineering at the University of Pennsylvania's school of medicine and investigator at the Abramson Family Cancer Research Institute, where he remains today. He is board-certified in internal medicine and oncology.
Research
June has been a pioneer in the field of immunotherapy, most widely known for the development of T-cell therapy for cancer. In the 1980s, his lab supported research for the CD28 molecule as the major control switch for T cells. A few years later, tested the ability to culture genetically modified CAR-Ts in humans, discovering the cells could engraft and persist in patients with HIV/AIDS for years. His work led to the development and commercialization of tisagenlecleucel, the first FDA-approved cell therapy.
Awards and honors
1978 - Alpha Omega Alpha Medical Society.
1978 - Michael E. DeBakey Scholar award for the Outstanding Medical Student, Baylor College of Medicine
1991 - Fellow, American College of Physicians.
1996 - Legion of Merit, US Navy
1996 - Dexter Conrad Award, Office of Naval Research, Navy’s highest award for Scientific Achievement
1997 - Frank Brown Berry Prize in Federal Medicine
2001 - Burroughs Wellcome Fund Award: visiting professor in the basic medical sciences
2002 - Lifetime Achievement Award, Leukemia and Lymphoma Society
2002 - William Osler Award, University of Pennsylvania School of Medicine
2005-09 - Bristol-Myers Squibb Freedom to Discover Award
2005 - Federal Laboratory Award for Excellence in Technology Transfer.
2012 - William B. Coley Award for Distinguished Research in Basic and Tumor Immunology
2012 - Earnest Beutler Lecture and Prize, American Society of Hematology
2012 - Elected to Institute of Medicine
2013 - The Philadelphia Award
2013 - Richard V Smalley Award, Society for Immunotherapy of Cancer
2014 - Elected to American Academy of Arts and Sciences.
2014 - Steinman Award for Human Immunology Research, American Association of Immunologists
2014 - Aubrey Evans Award / Ronald McDonald House
2014 - Karl Landsteiner Memorial Award, AABB.
2014 - Taubman Prize for Excellence in Translational Medical Science
2014 - Hamdan Award for Medical Research Excellence
2015 - Paul Ehrlich and Ludwig Darmstaedter Prize.
2015 - Watanabe Prize for Translational Research, Indiana University and Eli Lilly
2015 - Lifetime Achievement Award Lecture, Miami Winter Symposium
2015 - Debrecen Award for Molecular Medicine, University of Debrecen
2015 - AACR-CRI Lloyd J. Old Award in Cancer Immunology.
2015 - Award for Distinguished Research in the Biomedical Sciences, Association of American Medical Colleges
2015 - E. Donnall Thomas Award Lecture, American Society for Blood and Marrow Transplantation
2016 - John Scott Medal
2016 - Distinguished Graduate Award, U.S. Naval Academy.
2016 - Novartis Prize in Immunology
2016 - Clinical Research Achievement Award.
2017 - Karnofsky Prize, ASCO
2017 - Distinguished Scientist Award, Association of American Cancer Institutes
2018 - Time 100: The Most Influential People of 2018
2018 - Albany Medical Center Prize in Medicine and Biomedical Research.
2018 - Passano Prize
2019 - ACTS Distinguished Investigator: Translation from Proof-of-Concept to Applicability for Widespread Clinical Practice Award
2019 - Harrington Prize, American Society for Clinical Investigation
2019 - The Edward Netter Leadership Award, Alliance for Cancer Gene Therapy
2020 - Lorraine Cross Award
2020 - Elected member American Philosophical Society
2020 - Genome Valley Excellence Award, BioAsia
2020 - Elected member National Academy of Sciences
2021 - Dan David Prize
2021 - Outstanding Achievement Award, American Society of Gene & Cell Therapy
2022 - The Keio Medical Science Prize
2022 - Maria I. New International Prize for Biomedical Research
2023 - Phacilitate Lifetime Achievement Award
2023 - Clarivate Citation Laureates
2024 - Breakthrough Prize in Life Sciences
References
External links
Carl June Lab at University of Pennsylvania
Living people
United States Naval Academy alumni
United States Navy officers
Fellows of the American Academy of Arts and Sciences
Baylor College of Medicine alumni
American immunologists
1953 births
Members of the American Philosophical Society
Fred Hutchinson Cancer Research Center people