List of enzymes

List of enzymes
Enzymes are listed here by their classification in the International Union of Biochemistry and Molecular Biology's Enzyme Commission (EC) numbering system:
:Category:Oxidoreductases (EC 1) (Oxidoreductase)
Dehydrogenase
Luciferase
DMSO reductase
:Category:EC 1.1 (act on the CH-OH group of donors)
:Category:EC 1.1.1 (with NAD+ or NADP+ as acceptor)
Alcohol dehydrogenase (NAD)
Alcohol dehydrogenase (NADP)
Homoserine dehydrogenase
Aminopropanol oxidoreductase
Diacetyl reductase
Glycerol dehydrogenase
Propanediol-phosphate dehydrogenase
glycerol-3-phoshitiendopene dehydrogenase (NAD+)
D-xylulose reductase
L-xylulose reductase
Lactate dehydrogenase
Malate dehydrogenase
Isocitrate dehydrogenase
HMG-CoA reductase
:Category:EC 1.1.2 (with a cytochrome as acceptor)
:Category:EC 1.1.3 (with oxygen as acceptor)
Glucose oxidase
L-gulonolactone oxidase
Thiamine oxidase
Xanthine oxidase
Category:EC 1.1.4 (with a disulfide as acceptor)
:Category:EC 1.1.5 (with a quinone or similar compound as acceptor)
:Category:EC 1.1.99 (with other acceptors)
:Category:EC 1.2 (act on the aldehyde or oxo group of donors)
:Category:EC 1.2.1 (with NAD+ or NADP+ as acceptor)
Acetaldehyde dehydrogenase
Glyceraldehyde 3-phosphate dehydrogenase
Pyruvate dehydrogenase
:Category:EC 1.2.4
Oxoglutarate dehydrogenase
:Category:EC 1.3 (act on the CH-CH group of donors)
:Category:EC 1.3.1 (with NAD+ or NADP+ as acceptor)
Biliverdin reductase
:Category:EC 1.3.2 (with a cytochrome as acceptor)
:Category:EC 1.3.3 (with oxygen as acceptor)
Protoporphyrinogen oxidase
:Category:EC 1.3.5 (with a quinone or similar compound as acceptor)
:Category:EC 1.3.7 (with an iron–sulfur protein as acceptor)
:Category:EC 1.3.99 (with other acceptors)
:Category:EC 1.4 (act on the CH-NH2 group of donors)
:Category:EC 1.4.3
Monoamine oxidase
:Category:EC 1.5 (act on CH-NH group of donors)
:Category:EC 1.5.1 (with NAD+ or NADP+ as acceptor)
Dihydrofolate reductase
Methylenetetrahydrofolate reductase
:Category:EC 1.5.3 (with oxygen as acceptor)
Sarcosine oxidase
Dihydrobenzophenanthridine oxidase
:Category:EC 1.5.4 (with a disulfide as acceptor)
:Category:EC 1.5.5 (with a quinone or similar compound as acceptor)
:Category:EC 1.5.7 (with an iron–sulfur protein as acceptor)
:Category:EC 1.5.8 (with a flavin as acceptor)
:Category:EC 1.5.99 (with other acceptors)
:Category:EC 1.6 (act on NADH or NADPH)
:Category:EC 1.6.1 (with NAD+ or NADP+ as acceptor)
:Category:EC 1.6.2 (with a cytochrome as acceptor)
:Category:EC 1.6.3 (with oxygen as acceptor)
Category:EC 1.6.4 now :Category:EC 1.8.1
:Category:EC 1.6.5 (with a quinone or similar compound as acceptor)
NADH dehydrogenase
Category:EC 1.6.6 (with a nitrogenous group as acceptor)
Category:EC 1.6.7 now :Category:EC 1.18.1
Category:EC 1.6.8 now :Category:EC 1.5.1
:Category:EC 1.6.99 (with other acceptors)
:Category:EC 1.7 (act on other nitrogenous compounds as donors)
:Category:EC 1.7.1 (with NAD+ or NADP+ as acceptor)
:Category:EC 1.7.2 (with a cytochrome as acceptor)
:Category:EC 1.7.3 (with oxygen as acceptor)
Urate oxidase
:Category:EC 1.7.7 (with an iron–sulfur protein as acceptor)
:Category:EC 1.7.99 (with other acceptors)
Nitrite reductase
Nitrate reductase
:Category:EC 1.8 (act on a sulfur group of donors)
:Category:EC 1.8.1 (with NAD+ or NADP+ as acceptor)
Glutathione reductase
Thioredoxin reductase
:Category:EC 1.8.2 (with a cytochrome as acceptor)
:Category:EC 1.8.3 (with oxygen as acceptor)
Sulfite oxidase
:Category:EC 1.8.4 (with a disulfide as acceptor)
:Category:EC 1.8.5 (with a quinone or similar compound as acceptor)
Category:EC 1.8.6 deleted, included in EC 2.5.1.18
:Category:EC 1.8.7 (with an iron–sulfur protein as acceptor)
:Category:EC 1.8.98 (with other, known, acceptors)
:Category:EC 1.8.99 (with other acceptors)
:Category:EC 1.9 (act on a heme group of donors)
:Category:EC 1.9.3 (with oxygen as acceptor)
Cytochrome c oxidase
:Category:EC 1.9.6 (with a nitrogenous as acceptor)
Category:EC 1.9.99 transferred, now EC 1.9.98.1
:Category:EC 1.10 (act on diphenols and related substances as donors)
:Category:EC 1.10.1(with NAD+ or NADP+ as acceptor)
Category:EC 1.10.2 (with a cytochrome as acceptor)
Coenzyme Q - cytochrome c reductase
:Category:EC 1.10.3 (with oxygen as acceptor)
Catechol oxidase
Laccase
:Category:EC 1.10.99 (with other acceptors)
:Category:EC 1.11 (act on peroxide as an acceptor -- peroxidases)
:Category:EC 1.11.1 (peroxidases)
Cytochrome c peroxidase
Catalase
Myeloperoxidase
Thyroid peroxidase
Glutathione peroxidase
:Category:EC 1.12 (act on hydrogen as a donor)
:Category:EC 1.12.1 (with NAD+ or NADP+ as acceptor)
:Category:EC 1.12.2 (with a cytochrome as acceptor)
:Category:EC 1.12.5 (with a quinone or similar compound as acceptor)
:Category:EC 1.12.7 (with an iron–sulfur protein as acceptor)
:Category:EC 1.12.98 (with other known acceptors)
:Category:EC 1.12.99 (with other acceptors)
:Category:EC 1.13 (act on single donors with incorporation of molecular oxygen)
:Category:EC 1.13.11 (With incorporation of two atoms of oxygen)
4-hydroxyphenylpyruvate dioxygenase
:Category:EC 1.13.12 (With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases))
Renilla-luciferin 2-monooxygenase
Cypridina-luciferin 2-monooxygenase
Firefly luciferase
Watasenia-luciferin 2-monooxygenase
Oplophorus-luciferin 2-monooxygenase
:Category:EC 1.14 (act on paired donors with incorporation of molecular oxygen)
Cytochrome P450 oxidase
:Category:Cytochrome P450
Aromatase
CYP2D6
CYP2E1
CYP3A4
Cytochrome P450 oxidase
:Category:EC 1.14.12
Nitric oxide dioxygenase
:Category:EC 1.14.13
Nitric oxide synthase
:Category:EC 1.14.14
Aromatase
CYP2D6
CYP2E1
CYP3A4
:Category:EC 1.14.16
Phenylalanine hydroxylase
:Category:EC 1.14.18
Tyrosinase
:Category:EC 1.15 (act on superoxide radicals as acceptors)
:Category:EC 1.15.1
Superoxide dismutase
:Category:EC 1.16 (oxidize metal ions)
:Category:EC 1.16.3
Ceruloplasmin
:Category:EC 1.17 (act on CH or CH2 groups)
:Category:EC 1.17.1
Leucoanthocyanidin reductase
Xanthine dehydrogenase
Nicotinate dehydrogenase
4-hydroxy-tetrahydrodipicolinate reductase
:Category:EC 1.17.2
Nicotinate dehydrogenase (cytochrome)
:Category:EC 1.17.3
Xanthine oxidase
:Category:EC 1.17.4
Ribonucleotide reductase
Ribonucleoside-triphosphate reductase
Vitamin K epoxide reductase
Vitamin-K-epoxide reductase (warfarin-sensitive)
Vitamin-K-epoxide reductase (warfarin-insensitive)
RRM1
RRM2
RRM2B
:Category:EC 1.17.5
Caffeine dehydrogenase
:Category:EC 1.17.7
:Category:EC 1.17.99
:Category:EC 1.18 (act on iron–sulfur proteins as donors)
:Category:EC 1.18.6
Nitrogenase
:Category:EC 1.19 (act on reduced flavodoxin as donor)
:Category:EC 1.19.6
Nitrogenase (flavodoxin)
:Category:EC 1.20 (act on phosphorus or arsenic as donors)
:Category:EC 1.20.1
:Category:EC 1.20.2
:Category:EC 1.20.4
Arsenate reductase (glutaredoxin)
Glutaredoxin
:Category:EC 1.20.9
:Category:EC 1.20.99
:Category:EC 1.21 (act on X-H and Y-H to form an X-Y bond)
:Category:EC 1.21.1
Iodotyrosine deiodinase
:Category:EC 1.21.3
Isopenicillin N synthase
Tetrahydrocannabinolic acid synthase
:Category:EC 1.21.4
:Category:EC 1.21.99
Thyroxine 5-deiodinase
Iodothyronine deiodinase and
:Category:EC 1.97 (other oxidoreductases)
:Category:EC 1.97.1
Deiodinase
:Category:Transferases (EC 2) (Transferase)
Glutathione S-transferase
:Category:EC 2.1 (transfer one-carbon groups, Methylase)
:Category:EC 2.1.1
Catechol-O-methyl transferase
DNA methyltransferase
Histone methyltransferase ,
:Category:EC 2.1.3
Aspartate transcarbamoylase
Ornithine transcarbamoylase
:Category:EC 2.2 (transfer aldehyde or ketone groups)
:Category:EC 2.2.1
Transketolase
Transaldolase
Acetolactate synthase
2-Succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
:Category:EC 2.3 (acyltransferases)
:Category:EC 2.3.1
Aminolevulinic acid synthase
Choline acetyltransferase
:Category:EC 2.3.2
Factor XIII
Gamma glutamyl transpeptidase
Transglutaminase
:Category:EC 2.4 (glycosyltransferases)
:Category:EC 2.4.2
Hypoxanthine-guanine phosphoribosyltransferase
:Category:EC 2.5
:Category:EC 2.5.1
Thiaminase
:Category:EC 2.5 (transfer alkyl or aryl groups, other than methyl groups)
Flavin prenyltransferase
:Category:EC 2.6 (transfer nitrogenous groups)
:Category:EC 2.6.1
Alanine transaminase
Aspartate transaminase
:Category:EC 2.7 (transfer phosphorus-containing groups)
:Category:EC 2.7.2
Butyrate kinase
:Category:EC 2.8 (transfer sulfur-containing groups)
: Thiosulfate sulfurtransferase
: 3-mercaptopyruvate sulfurtransferase
: Thiosulfate—thiol sulfurtransferase
: tRNA uracil 4-sulfurtransferase
: Thiosulfate—dithiol sulfurtransferase
: Biotin synthase
: Cysteine desulfurase
: Lipoyl synthase
: Molybdenum cofactor sulfurtransferase
: Thiazole synthase
: Molybdopterin synthase sulfurtransferase
: Molybdopterin synthase
: tRNA-uridine 2-sulfurtransferase
: tRNA-5-taurinomethyluridine 2-sulfurtransferase
: tRNA-5-methyluridine(54) 2-sulfurtransferase
:Category:EC 2.9 (transfer selenium-containing groups)
: L-seryl-tRNA(Sec) selenium transferase
: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase
:Category:Hydrolases (EC 3) (Hydrolase)
Hydrolytic enzyme
:Category:EC 3.1 (act on ester bonds)
Nuclease
Endonuclease
Exonuclease
:Category:EC 3.1.1
Acid hydrolase
Phospholipase A
Acetylcholinesterase
Cholinesterase
Lipoprotein lipase
:Category:EC 3.1.2
Ubiquitin carboxy-terminal hydrolase L1
:Category:EC 3.1.3
Phosphatase
Alkaline phosphatase
Fructose bisphosphatase
:Category:EC 3.1.4
Phospholipase C
CGMP specific phosphodiesterase type 5
Phospholipase D
:Category:EC 3.1.21
Restriction enzyme Type 1
Restriction enzyme Type 2
Restriction enzyme Type 3
Restriction enzyme Type 4 (?)
Deoxyribonuclease I
:Category:EC 3.1.26
RNase H
:Category:EC 3.1.27
Ribonuclease
:Category:EC 3.2 (act on sugars - glycosylases)
:Category:EC 3.2.1
Amylase
Sucrase
Chitinase
Lysozyme
Maltase
Lactase
Beta-galactosidase
Hyaluronidase
Function and clinical importance of some enzymes in category 3.2.1
Amylase
Function: Amylase is an enzyme that is responsible for the breaking of the bonds in starches, polysaccharides, and complex carbohydrates to be turned into simple sugars that will be easier to absorb.
Clinical Significance: Amylase also has medical history in the use of Pancreatic Enzyme Replacement Therapy (PERT). One of the components is Sollpura (liprotamase), which help in the breakdown of saccharides into simple sugars.
Lysozyme
Function: An enzyme that is produced by animals that forms part of the innate immune system and is abundant in the secretions of saliva, human milk, tears, and mucus. It functions as an antimicrobial agent by splitting the peptidoglycan component of bacterial cell walls, which then leads to cell death.
Clinical Significance: Toxic levels of blood are caused by the excessive production of lysozyme's by cancer cells. Lysozyme's have also been associated with Bronchopulmonary dysplasia (BPD) in newborns and is a key factor in providing the immunology of infants during breast feeding.
Sucrase
Function: Sucrase is a stomachs related protein that mobilizes hydrolysis to convert sucrose into glucose and fructose.
Clinical Significance: Low amounts of Sucrose also known as Sucrose intolerance happens when sucrose isn’t being discharged in the small digestive tract. A result of this is extra gas.
Lactase
Function: lactase is located in the small digestives system of people and other creatures such as mammals. Lactase is the bases of the total absorption of milk.
Clinical Significance: People who are lactose intolerant have medicine that can help with the digestion. When you are lactose intolerant you might experience gas, bloating, and pain along with other symptoms regarding your digestive system.
:Category:EC 3.3 (act on ether bonds)
:Category:EC 3.3
Adenosylmethionine hydrolase
S-adenosyl-L-homocysteine hydrolase
Alkenylglycerophosphocholine hydrolase
Alkenylglycerophosphoethanolamine hydrolase
Cholesterol-5,6-oxide hydrolase
Hepoxilin-epoxide hydrolase
Isochorismatase
Leukotriene-A4 hydrolase
Limonene-1,2-epoxide hydrolase
Microsomal epoxide hydrolase
Trans-epoxysuccinate hydrolase
:Category:EC 3.4 (act on peptide bonds - Peptidase)
:Category:EC 3.4.11
Alanine aminopeptidase
:Category:EC 3.4.15
Angiotensin converting enzyme
:Category:EC 3.4.21
Serine protease
Chymotrypsin
Trypsin
Thrombin
Factor X
Plasmin
Acrosin
Factor VII
Factor IX
Prolyl oligopeptidase
Factor XI
Elastase
Factor XII
Proteinase K
Tissue plasminogen activator
Protein C
:Category:EC 3.4.22
Separase
:Category:EC 3.4.23
Pepsin
Rennet
Renin
Trypsinogen and (20/21/23/24/26)
Plasmepsin
:Category:EC 3.4.24
Matrix metalloproteinase
:Category:EC 3.4.25
Metalloendopeptidase
:Category:EC 3.5 (act on carbon–nitrogen bonds, other than peptide bonds)
:Category:EC 3.5.1 (In linear amides)
Urease
:Category:EC 3.5.2 (In cyclic amides)
Beta-lactamase
:Category:EC 3.5.3 (In linear amidines)
Arginase
:Category:EC 3.5.4 (In cyclic amidines)
Adenosine deaminase
GTP cyclohydrolase I
:Category:EC 3.5.5 (In nitriles)
Nitrilase
:Category:EC 3.6 (act on acid anhydrides)
:Category:EC 3.6.1
Helicase
DnaB helicase
RecQ helicase
:Category:EC 3.6.3
ATPase
NaKATPase
ATP synthase
:Category:EC 3.7 (act on carbon–carbon bonds)
Kynureninase
:Category:EC 3.8 (act on halide bonds)
EC 3.8.1.3 Haloacetate dehalogenase
:Category:EC 3.9 (act on phosphorus–nitrogen bonds)
: Phosphoamidase
: Protein arginine phosphatase
: Phosphohistidine phosphatase
:Category:EC 3.10 (act on sulfur–nitrogen bonds)
: N-sulfoglucosamine sulfohydrolase
: Cyclamate sulfohydrolase
:Category:EC 3.11 (act on carbon–phosphorus bonds)
: Phosphonoacetaldehyde hydrolase
: Phosphonoacetate hydrolase
: Phosphonopyruvate hydrolase
:Category:EC 3.12 (act on sulfur–sulfur bonds)
: Trithionate hydrolase
:Category:EC 3.13 (act on carbon–sulfur bonds)
: UDP-sulfoquinovose synthase
: 2'-hydroxybiphenyl-2-sulfinate desulfinase
: 3-sulfinopropanoyl—CoA desulfinase
: Carbon disulfide hydrolase
: (CysO sulfur-carrier protein)-S-L-cysteine hydrolase
: Carbonyl sulfide hydrolase
: S-adenosyl-L-methionine hydrolase (adenosine-forming)
:Category:Lyases (EC 4) (Lyase)
:Category:EC 4.1 (carbon–carbon lyases)
:Category:EC 4.1.1
Ornithine decarboxylase
Uridine monophosphate synthetase
Aromatic-L-amino-acid decarboxylase
RubisCO
:Category:EC 4.1.2
Fructose-bisphosphate aldolase
:Category:EC 4.2 (carbon–oxygen lyases)
:Category:EC 4.2.1
Carbonic anhydrase
Tryptophan synthase
:Category:EC 4.3 (carbon–nitrogen lyases)
:Category:EC 4.3.1
Phenylalanine ammonia-lyase
:Category:EC 4.4 (carbon–sulfur lyases)
:Category:EC 4.4.1
Cystathionine gamma-lyase
Cystathionine beta-lyase
Leukotriene C4 synthase
:Category:EC 4.5 (carbon–halide lyases)
:Category:EC 4.5.1
Dichloromethane dehalogenase
Halohydrin dehalogenase
:Category:EC 4.6 (phosphorus–oxygen lyases)
:Category:EC 4.6.1
Adenylate cyclase
Guanylate cyclase
:Category:Isomerases (EC 5) (Isomerase)
:Category:EC 5.1 (racemases and epimerases)
:Category:EC 5.1.1
Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing)
Serine racemase
:Category:EC 5.1.2
Mandelate racemase
:Category:EC 5.1.3
UDP-glucose 4-epimerase
:Category:EC 5.1.99
Methylmalonyl CoA epimerase
:Category:EC 5.2 (cis-trans-isomerases)
:Category:EC 5.2
FKBP: FKBP1A
FKBP1B
FKBP2
FKBP3
FKBP4
FKBP5
FKBP6
FKBP8
FKBP9
FKBP10
FKBPL
Cyclophilin
Parvulin
Prolyl isomerase
2-chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase
Beta-carotene isomerase
Farnesol 2-isomerase
Furylfuramide isomerase
Linoleate isomerase
Maleate isomerase
Maleylacetoacetate isomerase
Maleylpyruvate isomerase
Parvulin
Photoisomerase
Prolycopene isomerase
Prolyl isomerase
Retinal isomerase
Retinol isomerase
Zeta-carotene isomerase
:Category:EC 5.3 (intramolecular oxidoreductases)
:Category:EC 5.3.3
Enoyl CoA isomerase
:Category:EC 5.3.4
Protein disulfide isomerase
:Category:EC 5.4 (intramolecular transferases -- mutases)
:Category:EC 5.4.2
Phosphoglucomutase
:Category:EC 5.5 (intramolecular lyases)
:Category:EC 5.99 (other isomerases)
:Category:EC 5.99.1
Topoisomerase (type I: , type II: )
:Category:Ligases (EC 6) (Ligase)
:Category:EC 6.1 (form carbon–oxygen bonds)
6-carboxytetrahydropterin synthase
:Category:EC 6.1.1
FARSB
:Category:EC 6.2 (form carbon–sulfur bonds)
: Acetate—CoA ligase
: Medium-chain acyl—CoA ligase
: Long-chain-fatty-acid—CoA ligase
: Succinate—CoA ligase (GDP-forming)
: Succinate—CoA ligase (ADP-forming)
: Glutarate—CoA ligase
: Cholate—CoA ligase
: Oxalate—CoA ligase
: Malate—CoA ligase
: Acid—CoA ligase (GDP-forming)
: Biotin—CoA ligase
: 4-coumarate—CoA ligase
: Acetate—CoA ligase (ADP-forming)
: 6-carboxyhexanoate—CoA ligase
: Arachidonate—CoA ligase
: Acetoacetate—CoA ligase
: Propionate—CoA ligase
: Citrate—CoA ligase
: Long-chain-fatty-acid-luciferin-component ligase
: Long-chain-fatty-acid-(acyl-carrier-protein) ligase
: Transferred entry: 6.2.1.30
: (citrate (pro-3S)-lyase) ligase
: Dicarboxylate—CoA ligase
: Phytanate—CoA ligase
: Benzoate—CoA ligase
: o-succinylbenzoate—CoA ligase
: 4-hydroxybenzoate—CoA ligase
: 3-alpha,7-alpha-dihydroxy-5-beta-cholestanate—CoA ligase
: Transferred entry: 6.2.1.7
: Phenylacetate—CoA ligase
: 2-furoate—CoA ligase
: Anthranilate—CoA ligase
: 4-chlorobenzoate—CoA ligase
: Trans-feruloyl-CoA synthase
: ACP-SH:acetate ligase
: 3-hydroxypropionyl-CoA synthase
: 3-hydroxybenzoate—CoA ligase
: (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA synthase
: (butirosin acyl-carrier protein)—L-glutamate ligase
: 4-hydroxybutyrate-CoA ligase
: 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate-CoA ligase
: 3-oxocholest-4-en-26-oate-CoA ligase
: 2-hydroxy-7-methoxy-5-methyl-1-naphthoate-CoA ligase
: 3-(methylthio)propionyl-CoA ligase
: E1 ubiquitin-activating enzyme
: L-allo-isoleucine--holo-CmaA peptidyl-carrier protein ligase
: Medium-chain-fatty-acid-(acyl-carrier-protein) ligase
: Carnitine-CoA ligase
: Long-chain fatty acid adenylyltransferase FadD28
: 4-hydroxybenzoate adenylyltransferase FadD22
: 4-hydroxyphenylalkanoate adenylyltransferase FadD29
: L-firefly luciferin-CoA ligase
: L-proline-L-prolyl-carrier protein ligase
: D-alanine-D-alanyl-carrier protein ligase
: E1 SAMP-activating enzyme
:Category:EC 6.3 (form carbon–nitrogen bonds)
Glutamine synthetase
Argininosuccinate synthetase
CTP synthase
:Category:EC 6.4 (form carbon–carbon bonds)
Pyruvate carboxylase
Acetyl-CoA carboxylase
:Category:EC 6.5 (form phosphoric ester bonds)
DNA ligase
:Category:EC 6.6 (form nitrogen–metal bonds)
See also
List of EC numbers (EC 5)
List of EC numbers (EC 6)
Enzymes
Enzymes