Joseph Brain (academic)

Joseph Brain (academic)
Joseph David Brain, S.D. (born January 20, 1940) is an American physiologist and environmental health researcher, who is currently the Cecil K. and Philip Drinker Professor of Environmental Physiology at Harvard T.H. Chan School of Public Health, where he has taught and researched for over fifty years.
Early life
Brain was born in Paterson, New Jersey and reared in Wayne, New Jersey, and attended Eastern Christian High School in North Haledon, New Jersey, after which he went in 1957 to Taylor University in Upland, Indiana, where he majored in physics. After his graduation from (then) Taylor College, Brain was offered the Danforth Foundation Graduate Fellowship (1961-1966) at Harvard.
Education
High School Diploma, 1957, Eastern Christian High School, North Haledon, New Jersey
B.A. (Physics, Summa cum laude), 1961, Taylor University, Upland, Indiana
S.M., 1962, Harvard Paulson School of Engineering and Applied Sciences - on Danforth Foundation Graduate Fellowship (1961-1966)
S.M., 1963, Harvard Paulson School of Engineering and Applied Sciences - on Danforth Foundation Graduate Fellowship (1961-1966)
S.D., 1966, Harvard T.H. Chan School of Public Health - on Danforth Foundation Graduate Fellowship (1961-1966)
Career
Brain is currently the Cecil K. and Philip Drinker Professor of Environmental Physiology at Harvard T.H. Chan School of Public Health, and participates in the leadership of The Lown Institute. After graduation from Taylor, Brain was offered the Danforth Foundation Graduate Fellowship (1961-1966) at Harvard.
He is involved with a five-year collaboration signed between the University of Malaya (UM) and Harvard University in the search for more effective treatment of lung diseases through nanomedicine. Since 1998 he has been Director of the Kresge Center for Environmental Health at Harvard.
Dr. Brain was director of Respiratory Biology Program (1981-1993) and Physiology Program (1993-1997). He was also chair of the Department of Environmental Health at Harvard T.H. Chan School of Public Health (1990-2005).
Personal life
Brain is married and lives in Essex, Massachusetts. He served on the Taylor University Board of Trustees from 1988 to 2009.
Honors
U.S. Atomic Energy Commission Fellowship in Health Physics 1961-1962
Danforth Foundation Graduate Fellowship 1961-1966
USPHS Radiological Health Fellowship 1962-1966
NIH Research Career Development Award 1969-1974
Aaron Brown Lecturer (University of Pittsburgh) 1981
American Men and Women of Science 1982
Alumnus of the Year, Taylor University 1984
Fellow, American Association for the Advancement of Science 1987
NIH MERIT Award 1987-1995
Henry D. Chadwick Medal, Massachusetts Thoracic Society 1993
Honorary Professor of Huazhong University of Science and Technology (HUST), 1999, Wuhan, China
Selected publications
Lichtenstein JHR, Molina RM, Donaghey TC, Brain JD. Strain differences influence murine pulmonary responses to Stachybotrys chartarum. Am J Respir Cell Mol Biol. 2006; 35:415-23.
Trujillo JR, Rogers R, Molina RM, Dangond F, McLane MF, Essex M, Brain JD. Non-infectious entry of HIV-1 into peripheral and brain macrophages mediated by the mannose receptor. PNAS. 2007; 104(12):5097-5102.
Molina RM and Brain JD. In vivo comparison of cat alveolar and pulmonary intravascular macrophages: phagocytosis, particle clearance, and cytoplasmic motility. Exp Lung Res. 2007; 33(2):53-70.
Brain JD, Curran MA, Donaghey T, Molina R. Responses of the lungs to nanomaterials depend on exposure, clearance, and material characteristics. Nanotoxicology. 2009; 3(1-4):173-9.
Bellows CF, Molina RM, Brain JD. Diminished organelle motion in murine Kupffer cells during the erythrocytic stage of malaria. J R Soc Interface. 2011 May 6;8(58):711-9.
Lichtenstein JHR, Molina RM, Donaghey TC, Amuzie C, Pestka JJ, Coull BA, Brain JD. Pulmonary responses to Stachybotrys chartarum and its toxins: Mouse strain affects clearance and macrophage cytotoxicity. Toxicol Sci. 2010 Jul;116(1):113-21.
Molina RM, Phattanarudee S, Kim J, Thompson K, Wessling-Resnick M, Maher TJ, Brain JD. Ingestion of Mn and Pb by rats during and after pregnancy alters behavior in offspring. NeuroToxicology. 2011; 32(4):413-22.
Thompson K, Molina R, Donaghey T, Schwob J, Brain JD. Manganese uptake and distribution in the brain after methyl bromide-induced lesions in the olfactory epithelia.Toxicol Sci. 2011 Mar;120(1):163-72.
Mendivil CO, Teeter JG, Finch GL, Schwartz PF, Riese RJ, Kawabata T, Brain JD. Trough insulin levels in bronchoalveolar lavage following inhaled human insulin (Exubera®) in patients with diabetes mellitus. Diabetes Technol Ther. 2012; 14(1):50-8.
Molina R, Schaider L, Donaghey T, Shine J, Brain JD. Mineralogy affects geoavailability, bioaccessibility and bioavailability of zinc. Environ Pollut. 2013; 182:217-24.
Pirela S, Molina R, Watson C, Cohen J, Bello, Demokritou P, Brain JD. Effects of copy center particles on the lungs: A toxicological characterization using a Balb/c mice model. Inhalation Toxicology. 2013; 25(9):498-508.
Molina RM, Konduru NV, Jimenez RJ, Wohlleben W, Brain JD. Bioavailability, distribution and clearance of tracheally instilled, gavaged or injected cerium dioxide nanoparticles and ionic cerium. Environ Sci: Nano. 2014; 1:561-73.
Brain JD, Kreyling WG, and Godleski JJ. Inhalation Toxicology. In: Hayes’ Principles and Methods of Toxicology. Sixth Edition. Edited By: A. Wallace Hayes and Claire L. Kruger. CRC Press: Boca Raton. 2014. Pages 1385–1444.
Mendivil CO, Koziel H, Brain JD. Metabolic hormones, apolipoproteins, adipokines, and cytokines in the alveolar lining fluid of healthy adults: compartmentalization and physiological correlates. PLoS One. 2015 Apr 7;10(4):e0123344 (15 pages).
Rosenblum-Lichtenstein JH, Hsu Y-H, Gavin IM, Donaghey TC, Molina RM, Thompson KJ, Chi C-L, Gillis BS, Brain JD. Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses. PLoS One. 2015 May 26;10(5):e0126926. (22 pages)
Watson CY, Damiani F, Ram-Moham S, Rodrigues S, de Moura Queiroz P, Donaghey TC, Rosenblum Lichtenstein JH, Brain JD, Krishnan R, Molina RM. Screening for chemical toxicity using cryopreserved precision cut lung slices. Toxicological Sciences. 2016;150(1):225-33.
Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu YH, Mathews JA, Kasahara DI, Park JA, Bordini A, Godleski JJ, Gillis BS, Brain JD. Repeated mouse lung exposures to Stachybotrys chartarum shift immune response from type 1 to type 2. Am J Respir Cell Mol Biol. 2016 May 5. [Epub ahead of print]
References
External links
Harvard-NIEHS Center for Nanotechnology and Nanotoxicology
Taylor University profile of Joseph D. Brain, Taylor alum
1940 births
Living people
Harvard T.H. Chan School of Public Health faculty
American physiologists
Harvard John A. Paulson School of Engineering and Applied Sciences alumni
Taylor University alumni
People from Essex, Massachusetts
People from Paterson, New Jersey
People from Wayne, New Jersey
Nanomaterials
Harvard T.H. Chan School of Public Health alumni