{{Infobox University
| name = DePaul University
| native_name = Vincent DePaul University
| image = RichardsonLibraryDePaul.jpg
| motto = .
| mottoeng = "I will show you the way of wisdom."
| established = 1898年
| type = 私立、研究大学
| endowment = 約595.8億ドル (2018)
| president = A. Gabriel Esteban
| undergrad = 15,407人
| postgrad = 7,703人
| city = シカゴ
| state = イリノイ州
| country = 
| coordinates = 
| campus = Lincoln Park, 36 acres and downtown Loop
| former_names = St. Vincent's College (1898-1907)
| free_label = Academic term
| free = Quarter
| colours = Royal Blue & Scarlet 
| nickname = Blue Demons
| sporting_affiliations = NCAA Division I – Big East
| website = 
| logo = 
}}

デポール大学は、アメリカ合衆国（イリノイ州）シカゴに本部を置く米国の総合私立大学である。1898年に設置された。全米でも最大規模の研究型私立大学で、多様な人種を受けいれている。2017年の学生数は約22,000人（学部生15,000人、大学院生7,700人）で、世界130カ国から多くの留学生が学ぶ。学期は、クオーター制を採用している。 

キャンパスのある大都市シカゴという好立地を生かし、インターンシッププログラムに力を入れている大学の一つである。毎年多くの学生が有名企業でのインターンシップを経験している。

人気の専攻はビジネス、マーケッティング、映画学、コンピューターサイエンスなど。特にビジネスは全米でも高くランキングされている。2019年のプリンストンレビューではEntrepreneurship(起業学)ランキングで全米13位と評価された。また、数多くのビリオネアを輩出していることでも有名。日本人の宮本ゆき（広島出身、被爆2世）が教授として倫理学を教えている。

 キャンパス 
 Lincoln Park Campus 
 College of Education
 College of Science and Health
 School of Music
 The Theatre School
 College of Liberal Arts and Social Sciences

 Loop Campus 
 Driehaus College of Business
 College of Computing and Digital Media
 College of Law
 School for New Learning
 College of Communication

 学部・専攻 
 College of Education　
 College of Science and Health
 School of Music
 The Theatre School
 College of Liberal Arts and Social Sciences
 Driehaus College of Business
 College of Computing and Digital Media
 College of Law
 School for New Learning
 College of Communication

 学生構成 

学生 / 教員の数の比： 16/1

男女比

 男子約 48%

 女子約 52%

寮生 / 通学生の割合

 寮生 約18%

 通学生 約82%

留学生の割合：約3％

 ランキング 
 U.S.News & World Report大学ランキング 
 Best Value Schoolランキング：全米第54位

 The Princeton Review 
 Entrepreneurship(起業)ランキング：全米第13位(2019年度）

 NICHEランキング 

 Information Technology(情報技術学部)：全米第10位(2019年度)
 Accounting and Finance(会計・財務学部)：全米第44位(2019年度)
 Film and Photography(映画学部)：全米第44位(2019年度)

 著名な出身者 
 ビジネスマン 
 Curtis J. Crawford, CEO, XCEO, Inc.
 Richard Driehaus, CEO, Driehaus Capital Management
 Dan Evans, former vice president and general manager, Los Angeles Dodgers
 Jack Greenberg, former CEO, McDonald's Corporation
 Kerrie L. Holley, chief architect of IBM Global Services and IBM distinguished engineer; IBM Black Engineer of the Year Award Recipient 2003
 Martin Jahn, general director, Volkswagen Group RUS
 Cameron James, CEO and chairman; Goldman Sachs Circa 1996; died 1995 after graduating from Stanton
 James M. Jenness, former CEO, Kellogg Company
 Philip Kotler, Northwestern University, S.C. Johnson & Son Professor in International Marketing, known as the "father of modern marketing"
 Daniel Ustian, chairman, president and chief executive officer, Navistar International Corp.

 政治家・知事・公民権運動の指導者 
 Frank Annunzio, U.S. Representative from Illinois (1965–1993)
 Edwin B. Bederman, Illinois state representative
 Michael A. Bilandic, former mayor of Chicago
 Dorothy Brown, clerk of Cook County Circuit Court
 Anne M. Burke, Illinois Supreme Court Justice, 1st District
 Joseph Burke, judge of the Illinois Appellate Court (1939–76)
 Richard J. Daley, former mayor of Chicago
 Richard M. Daley, former mayor of Chicago
 Terrance Gainer, Sergeant at Arms of the United States Senate
 Arthur Goldberg, former justice of the United States Supreme Court
 Benjamin Hooks, former executive director of the NAACP
 Theodore Matlak, former 32nd ward Chicago alderman
 Walter J. Nega, Illinois state senator
 George Papadopoulos, oil and energy consultant and convicted felon.
 Samuel Skinner, former chief federal prosecutor, U.S. Secretary of Transportation; Chief of Staff to President George H. W. Bush
 Laura Spurr, chairwoman of the Nottawaseppi Huron Band of Potawatomi (2000–2001, 2003–2010)
 Charles E. Tucker, Jr., U.S. Air Force Major General
 Nadao Yoshinaga, Hawaii Senator

 スポーツ選手 
 Mark Aguirre, forward, NBA 1982–1994 (Dallas, Detroit)
 Bill Boedeker, halfback, NFL 1946–1950 (four teams)
 Andre Brown, forward, NBA 2007–present (currently with Bandırma Banvit of Turkey)
 Latasha Byears, women's basketball player in the WNBA
 Wilson Chandler, forward, NBA 2007–present (currently with Philadelphia 76ers)
 Tyrone Corbin, forward, NBA 1985–2000 (nine teams)
 Dave Corzine, center, NBA 1978–1990 (five teams)
 Terry Cummings, forward, NBA 1982–2000 (seven teams)
 Kevin Edwards, guard, NBA 1988–2001 (four teams)
 Marty Embry, center, drafted by the Utah Jazz in 1986, played professionally overseas for 13 years
 Elene Gedevanishvili, Georgian figure skater
 Sarah Gorden, defender, NWSL 2016–present (currently with Chicago Red Stars)
 Stephen Howard, forward, NBA 1992–1998 (three teams)
 Kelli Hubly, defender, NWSL 2017–present (currently with Portland Thorns FC)
 Steven Hunter, center, NBA 2001–2010
 Johnny Jorgensen, guard, professional basketball, 1947-49
 Mabel Landry, track and field
 George Mikan, one of the NBA's 50 greatest players
 Angelo Poffo, professional wrestler; father of "Macho Man" Randy Savage
 Allie Quigley, guard, WNBA 2008–present (currently with Chicago Sky)
 Quentin Richardson, guard, NBA 2000–2013
 Bobby Simmons, guard, NBA 2001–2010
 Julianne Sitch, defender, NWSL 2001–2014
 Rod Strickland, guard, NBA 1988–2005 (nine teams)
 Erin Walter, midfielder, USL W-League 2006–2009
 Rebekkah "Smokey" Jarvey, Offensive and Defensive line, Madison Blaze Women's Professional Football Team, Wisconsin Dragons Women's Professional Football Team (2017-current)

 俳優・ミュージシャン 
 Gillian AndersonActivist, Actor, Voice acting
 John C. Reilly, American actor
 Joe Keery, Actor
 Judy Greer, Television producer, Actor, Voice acting
 Monique ColemanEntrepreneur, Actor, Singer
 Sean Gunn, Actor
 Joe Mantegna, American actor
 Tarell Alvin McCraney, American playwright, Actor
 Pete WentzBassist, Businessperson, Guitarist
 John Barrowman, Actor, Singer, Writer
 Elizabeth PerkinsActor, Voice acting

 作家 
 Kay Ulanday Barrett, poet, educator, cultural worker
 William Granger, Chicago Tribune and Chicago Sun-Times columnist; author of The November Man series of novels
 Patrick Hicks, novelist, poet
 Tarell Alvin McCraney, playwright and winner of 2017 Oscar for Best Adapted Screenplay
 Thomas Moore, author of Care of the Soul Christian Picciolini, author of the autobiography Romantic Violence: Memoirs of an American Skinhead;[1] contributor to Google Executive Chairman Eric Schmidt and Google Ideas Director Jared Cohen's 2013 book The New Digital Age Sean Stephenson, author of Get Off Your "But"''