The Key to Natural Weight Management Support Presented by Sabinsa Corporation
A bioavailable combination of natural ingredients that addresses multiple targets in weight management: ✓Supports Lean Body Mass and Healthy Body Composition ✓Promotes satiety ✓Provides Antioxidant support
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Composition ▷ Composition of LeanGard*: ✓ForsLean* ✓ GarCitrin* ✓BioPerine* The beneficial effects of LeanGard are best obtained when the supplement is used in conjunction with a sensible diet and healthy life style measures. ▷ Suggested Use level: ✓500mg taken twice daily. *Trademarks of Sabinsa Corporation
ForsLean R (Coleus forskohlii extract, 10% forskolin): Forskolin helps build lean body mass and maintain healthy body composition through cAMP mediated action
GarCitrin®
(Garcinia cambogia Extract): Hydroxycitric acid in combination with garcinol supports satiety, weight management, and lean body mass ; provides antioxidant support. Effectively intervenes in the conversion of Carbohydrates to fat through ATP citrate lyase inhibition BioPerine® (Piper nigrum Extract): Enhances uptake and utilization of the natural actives. Our Innovation Is Your Answer®
A ForsLean® is a powdered extract from the root of Coleus forskohlii.んStandardized to contain 10% forskolin. A ForsLean® is well-tolerated and without adverse side effects. A At  500mg/day for up to 12 weeks, produced no significant detrimental effects on biochemistry, hematological parameters, blood pressure or thyroid functions. Expert Review Report from Cantox Health Sciences International ON, Canada, August 2004 www.forslean.com
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ForsLean® Adenylate cyclase enzyme Cyclic AMP Activates Hormone sensitive lipase Decrease in body fat Increased activity of anabolic hormones, insulin Increased lean body mass Healthy body composition Our Innovation Is Your Answer®
■  Open field study (8 weeks) with 6 overweight women subjects – Dr. A. Conte, USA ■  Open-field study (6 months) with 16 obese subjects – Dr. Asano, Japan ■ Pilot clinical efficacy and safety study, 19 women subjects, randomized, double blind placebo controlled – University of Memphis TN, USA ■ Preclinical toxicology evaluation – CBPRC, Bombay ■  60 subject clinical efficacy study – CBPRC, Bombay ■  24 subject clinical efficacy study – Northern Michigan University, USA
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■ Double-blind placebo controlled study, 30 obese/overweight subjects – Kansas State University, USA 60 subject clinical efficacy study– Manipal, India 6 month feeding/toxicity study – India ■  Micronucleus assay and dose effects studies – India Bone Density and Hormonal Levels Study, Mumbai, India ■  Hormonal Study (3months) with 30 male subjects, Manipal, India
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Won the Nutracon Best Product Award, 2001 US Patent # 5,804,596, won the Thomas Alva Edison Patent Award (R & D Council, NJ, USA) in 2004
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✓ A safe, naturally derived, effective dietary ingredient composition > Patented* for use in promoting lean body mass Clinically tested in humans (multiple studies) Kosher & Halal Certified > A tried and tested ingredient that manufacturers, retailers and consumers can have confidence in U.S. Patent # 5,804,596, European Patent # EP0977564, Canadian Patent # CA2281562
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GarCitrin®
U.S. Patent #7,063,861, Australia: AU773081, Europe: EP1254209, New Zealand: NZ 518116
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▷ Garcinol : ✔ amplifies the biological action of HCA ✓ contributes antioxidant activity to the formulation. ▷ The combination of calcium salt of HCA and Garcinol reduces fatty acid and lipid synthesis and improves lean body mass much more effectively than HCA alone.
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▷ GarCitrin® is statistically more effective than HCA in: ✓ reducing total body weight and body mass index ✓ reducing body fat ✓ increasing lean body mass and content of body water ✓ reducing levels of appetite perception ▷ GarCitrin® and HCA did not produce subjective or objective side effects.
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▷ BioPerine® is a patented standardized extract obtained from black pepper, containing not less than 95% piperine. ▷ A clinically proven natural bioavailability enhancer for nutrients.
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Possible mechanisms for increased Nutrient bioavailability Increases blood supply to the GI tract Increases emulsifying content of the gut Increases active nutrient transport
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1. U.S. Patent 5,536,506 2. U.S. Patent  5,744,161 3. U.S. Patent 5,972,3821 4. U.S. Patent  6,054,585 5. European Patent # EP0810868 6. Japan Patent # 3953513 7. Canada Patent # 2247467 www.bioperine.com
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The Lean Gard ® Clinical Trial
Placebo controlled randomized double blind parallel-group study comparing the efficacy and safety.
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No. of volunteers    : 50 over-weight subjects in each group comprising of 24 Men and 26 Women ranging in age from 25 to 55 years. Study duration : 12 weeks. Schedule of visits Visit 3 Baseline  Visit 1 Visit 2 Visit 4 Week 6   Week 9 Week 0    Week 3 Week 12
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Dosage 500mg of the LeanGard® or Placebo was given twice daily to the participants of the trial.
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■ % Change
■ % Decrease
% Decrease
■ % Increase
*Please note: The relationship between BMR and obesity is complex. BMR  increases with obesity and overfeeding,  a “coping mechanism” by the body. The results here indicate that   LeanGard  by supporting  a healthy body composition, beneficially modulates increased  BMR in obese/overweight subjects. Our Innovation Is Your Answer®
% Decrease
* Please Note: TBW: 4.66% average loss in Total Body Water from baseline corresponds to about 1.95 kg or about 4.29 lb. The actual average reduction in body fat corresponds to about 8.82 kg, or about 19.4 lb. Water forms roughly about 25% of the fat lost w/w, which corresponds to about 2.03 kg or 4.4 Ib by weight. So essentially, the total body water lost can be related to water in the lost fat Our Innovation Is Your J Hence the intervention, LeanGard has no detrimental effects on hydration.
No significant changes in – Blood pressure or Heart rate – Hematological parameters – Liver function – Renal function – Thyroid function – Plasma lipid levels
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Significance at P< 0.05. V1-visit 1, V2-visit 2, V3-visit 3, V4-visit 4.
Percentage change in body fat, lean body mass and body weight (n=50) * Statistical significance of p<0.01 between the groups Conclusion LeanGard® is an effective and clinically safe dietary intervention for weight management support.
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Thank You LeanGard® For a Healthy Body Composition
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