Birth;  September , 1940, Japanese Education; Ph. D. in Chemistry (1969) from Osaka University
Professional
1966.4 – 1979.3 Assistant professor, Institute for Protein Research, Osaka Univ. 1979.4 – 1983.3 Associate Professor, Medical School of Osaka University 1983.4 – 2000.3   Professor at Institute for Molecular Science 1985.4 – 1986.3 Adjunct Professor, Tokyo Institute of Technology 1992.4 – 2005.3 Department head, Institute for Molecular Science 1999.4 – 2000.3  Professor, Institute for Basic Biology, Okazaki National Institutes 2000.4 – 2006.3   Professor, Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences 2001.4 – 2002.3 Adjunct Professor, Tohoku University Director, Okazaki Institute for Integrative Bioscience 2003.4 – 2005.3 2003.4 – 2005.3 Adjunct Professor, Kyushu University Emeritus Professor, Institute for Molecular Science, National 2006.3 – Institutes of Natural Sciences 2006.4 – Present    Fellow, Toyota Physical and Chemical Research Institute 2007.2 – Present Professor, Picobiology Institute, Graduate School of Life Science, University of Hyogo 2008.4 – present Fellow of the Chemical Society of Japan 2005.10 – 2008.9   Member of the Science Council of Japan, vice-chairman of Chemistry Sub-committee, Chairman of IUPAC sub-committee 2008.10 – 2011.9  Associate Member of the Science Council of Japan

Honors:
2002.3 The Chemical Society of Japan Award 'Investigation of Structure and Dynamics of Heme Proteins by Using Time-resolved Resonance Raman Spectroscopy' 1996.5 Science Award of the Spectroscopic Society of Japan ‘Investigation of Structural Chemistry of Biomolecules by Using Vibrational Spectroscopy' 1988.3 The Chemical Society of Japan Award for Creative Work 'Elucidation of Microscopic Structures of Active Site in Heme Proteins by Using Resonance Raman Spectroscopy' 2012. 2 Mizushima-Raman Lectureship Award of JSPS/DST 2012. 7 Eraldo Antonini Award for Lifetime Contributions to the Understanding of Hemes, 7 th International Conference on Porphyrins and Phthalocyanines 2012.11 AsBIC Outstanding Achievement Award, 6 th  Asian Biological Inorganic Chemistry Conference.
Social Activities and Services for Scientific Societies
Editorial Work for Journals
Journal of Physical Chemistry： Advisory Board    (1993-1997). Chemical Physics  :   Advisory Board   (1993-). Journal of Molecular Liquids: , Editorial Board  (1993 - 2009). Asian Journal of Physics:  Advisory Board  (1991-). J. Polymer Science, Biospectroscop:   Editorial Board  (1993-). Journal of Raman Spectrocopy:   Advisory Board  (1995-). Journal of Biological Inorganic Chemistry:  Advisory Board  (1995-1997). Journal of Biological Inorganic Chemistry:  Editorial Board  (1999-2002). Journal of Inorganic Biochemistry:  Editorial Board  (2001-2004). Chemistry Letters:  Editorial Staff Member (2003-2004). Bulletin of Chemical Society of Japan:  Advisory Board   (2005-). Officers of Scientific Societies and Committee Members International Union of Pure and Applied Chemistry: Associate Member of Commission on Biophysical Chemistry (1996.1-1997.1) Society of Biological Inorgaic Chemistry:  Council Member ( 2001.10~2005.9 ). Councilor of the Spectroscopic Society of Japan (1987- ) Chairman of Selection Committee of The Chemical Society Award (1999). Councilor of the Biochemical Society of Japan (1999- ) Director of the Chemical Society of Japan (2002-2003). Vicepresident of the Chemical Society of Japan (2003-2004) Fellow of the Chemical Society of Japan (2008- ) Inspector of the Chemical Society of Japan (2009-2010) Member of the Science Council of Japan (2005.10 – 2008.9) Vice-chairman of Chemistry Division Subcommittee, Chairman of IUPAC Subcommittee, and Chairman of Physical chemistry and Biophysical chemistry Division Subcmmittee Associate Member of the Science Council of Japan (2008.0 - ) Chairman of Physical chemistry and Biophysical chemistry Division Subcommittee. Honorary Member of the Spectroscopic Society of Japan (2022.5- ) Organizing Committee Members of International Conferences Internatinal Conference on Raman Spectroscopy, International Steering Commitee (1988-1994). International Conference on Time Resolved Vibrational Spectroscopy, International Organizing Commitees (1989-). 11th International Conferens on Photobiology, Symposium organizer (1992). Vth Intr1. Conf. on Time-resolved Vibrational Spectroscopy(Tokyo), Loca1 Organizing Committee (1991). Symposium on Recent Developments in Vibrational Spectroscopy, International Chemical Congress of Pacific Basin Societes (one of organizers). Co-organization: US-Japan Symposium on "Ligand Binding to Myoglobin and Hemoglobin" Rice University, Houston, March, 1-5 (1997). Co-organization: US-Japan Symposium on "Proton Coupled Electron Transfer" Kona,Hawaii, Nov. 11-15 (1998). Co-organization: Symposium in International Chemical Congress of Pacific Basin Societies "Raman Spectroscopy: Coming Age in the New Millennum" Hawaii, Dec 14-18 (2000). Co-organization: 10th International Conference on Time-resolved Vibrational Spectroscopy, Okazaki, May 21-25 (2001). Organizer: 2002 IMS COE Conference "Dynamical Structures and Molecular Design of Metalloproteins", Nov. 18-21 (2002). Organizer: AsBIC-1 "The First Asian Meeting of Bioinorganic Chemistry" Okazaki, March 7-10 (2002). Chairman of International Steering Committee of "Asian Conference on Biological Inorganic Chemistry" Chairman of Steering Committee  of AsBIC (2002~2008) I 1. Books Introduction to Raman Spectroscopy (in Japanese) by T. Kitagawa and An. Tu (1 9 8 8) 2. Chan's Physical Chemistry (Translation)  (by Y. Iwasawa, H. Hamguchi, and T. Kitagawa) (2 0 0 4 ) 3. Chan's Physical Chemistry Digest Version (Translation)(by Y. Iwasawa, ( 2 0 0 6 ) H. Hamaguchi, and T. Kitagawa)
II.
Original Papers
1. Miyazawa, T. and T. Kitagawa, Crystal vibrations, specific heat, and elastic moduli of the polyethylene crystal. J. Polymer Sci. Ser. B 2: p. 395-397 1964. 2. Kitagawa, T. and T. Miyazawa, Inelastic scattering cross section of neutron by crystal vibrations of polyethylene. J. Chem. Phys. 47: p. 337-338 1967. 3. Kitagawa, T. and T. Miyazawa, Cross-section for multi-phonon scattering of neutrons by crystalline polyethylene. J. Polymer Sci. Ser. B 6: p. 83-86 1968. 4. Kitagawa, T. and T. Miyazawa, Energy difference between rotational isomers of methyl ethyl ether. Bull. Chem. Soc. Jpn. 41: p. 1976 1968. 5. Kitagawa, T. and T. Miyazawa, Energy difference between rotational isomers of methyl ethyl ether. Bull. Chem. Soc. Jpn. 42: p. 3437-3447 1969. 6. Kitagawa, T. and T. Miyazawa, Frequency distribution and dispersion curves of crystal vibrations of perdeuterated polyethylene. Polymer J. 1: p. 471-479 1970. 7. Kitagawa, T. and T. Miyazawa, Frequency distribution, specific heat and Young's moduli of orthorhombic polyethylene with skeletal approximation. Bull. Chem. Soc. Jpn. 43: p. 372-379 1970. 8. Kitagawa, T., A. Tanaka, and M. Nishii, End-group orientation in crystalline polyoxymethylene. J. Polymer Sci. Ser B 9: p. 579-582 1971. 9. Kitagawa, T., K. Ohno, H. Sugeta, and T. Miyazawa, Far infrared spectra and internal-rotation potential of ethyl methyl ether. Bull. Chem. Soc. Jpn. 45: p. 969-975 1972. 10. Kitagawa, T., K. Kusaki, and T. Miyazawa, Raman spectra and internal rotation of ethyl methyl ether. Bull. Chem. Soc. Jpn. 46: p. 3685-3687 1973. 11. Okabayashi, H., M.Okuyama, T. Kitagawa, and T. Miyazawa, The Raman spectra and molecular conformations of surfactants in aqueous solution and crystalline state. Bull. Chem. Soc. Jpn. 47: p. 1075-1077 1974. 12. Ikeda-Saito, M., T. Kitagawa, T. Iizuka, and Y. Kyogoku, Resonance Raman scattering from hemoproteins; pH-dependence of Raman spectra of ferrous di-carboxymethyl-methionyl-cytochrome c. FEBS Lett. 50: p. 233-235 1975. 13. Kitagawa, T., T. Iizuka, M.Saito, and Y. Kyogoku, Resonance Raman scattering from hemoproteins: The nature of the bond between the sixth ligand and the heme iron in ferrous low spin derivatives of hemoglobin. Chem. Lett.: p. 849-852 1975. 14. Kitagawa, T., Y. Kyogoku, T. Iizuka, M. Ikeda-Saito, and T. Yamanaka, Resonance Raman scattering from hemoproteins: Effects of ligands upon Raman spectra of various c-type cytochromes. J. Biochem. (Tokyo) 78: p. 719-728 1975. 15. Kitagawa, T., H. Ogoshi, E. Watanabe, and Z. Yoshida, Resonance Raman spectra of metalloporphyrins: On the methine-bridge vibrations of ferric octaethylporphyrins and its α, β, γ, and δ deuterated derivatives. Chem. Phys. Lett. 30 : p. 451-457 1975. 16. Kitagawa, T., H. Ogoshi, E. Watanabe, and Z. Yoshida, Resonance Raman scattering from metalloporphyrins. Metal and ligand dependence of the vibrational frequencies of octaethylporphyrins. J. Phys. Chem. 79: p. 2629-2635 1975. 17. Okabayashi, H., M. Okuyama, and T. Kitagawa, The Raman spectra of surfactants and the concentration dependence of their molecular conformations in aqueous solutions. Bull. Chem. Soc. Jpn. 48: p. 2264-2269 1975. 18. Abe, M., T. Kitagawa, and Y. Kyogoku, Vibrational assignment of resonance Raman lines of Ni(octaethylporphyrin) on the basis of a normal coordinate treatment, in Chem. Lett. 1976. p. 249-252. 19. Kitagawa, T., M. Abe, Y. Kyogoku, H. Ogoshi, E. Watanabe, and Z. Yoshida, Resonance Raman spectra of metallo-octaethylporphyrins. Low frequency vibrations of porphyrin and iron-axial ligand stretching modes. J. Phys. Chem. 80: p. 1181-1186 1976. 20. Kitagawa, T., Y. Kyogoku, T. Iizuka, and M.I. Saito, Nature of the iron-ligand bond in ferrous low spin hemoproteins studied by resonance Raman scattering. J. Am. Chem. Soc. 98: p. 5169-5173 1976. 21. Ozaki, Y., T. Kitagawa, and Y. Kyogoku, Raman study of the acid-base transition of ferric myoglobin: Direct evidence for the existence of two molecular species at alkaline pH. FEBS Lett. 62: p. 369-372 1976. Ozaki, Y., T. Kitagawa, Y. Kyogoku, H. Shimada, T. Iizuka, and Y. Ishimura, An anomaly in resonance Raman spectra of cytochrome P-450cam in the 22. ferrous high spin state. J. Biochem. (Tokyo) 80: p. 1447-1451 1976. 23. Kitagawa, T., M. Abe, Y. Kyogoku, H. Ogoshi, H. Sugimoto, and Z. Yoshida, Resonance raman spectra of 15 N enriched metallo-octaethylporphyrins. Characterization of the oxidation state marker bands of hemoproteins. Chem. Phys. Lett. 48: p. 55-58 1977. 24. Kitagawa, T., Y. Kyogoku, and Y. Orii, Resonance Raman spectra of heme a derivatives. Evidence for the reaction of peripheral formyl group with HCN and NaHSO3. Arch. Biochem. Biophys. 181: p. 228-235 1977. 25. Kitagawa, T., Y. Ozaki, Y. Kyogoku, and T. Horio, Resonance Raman study of the pH-dependent and detergent-induced structural alterations in the heme moiety of r. Rubrum cytochrome c'. Biochim. Biophys. Acta 495: p. 1-11 1977. 26. Kitagawa, T., Y. Ozaki, J. Teraoka, Y. Kyogoku, and T. Yamanaka, The pH dependence of the resonance Raman spectra and structural alterations at heme moieties of various c-type cytochromes. Biochim. Biophys. Acta 494: p. 100-114 1977. 27. Mido, Y., F. Fujita, and T. Kitagawa, Accordion-like skeletal motions of CH3NHCONH(CH2)nCH3 (n=1-15). Bull. Chem. Soc. Jpn. 50: p. 1621-1622 1977. 28. Abe, M., T. Kitagawa, and Y. Kyogoku, Resonance raman spectra of octaethylporphyrinato-Ni(II) and meso-deuterated and 15N substituted derivatives. II. A normal coordinate analysis. J. Chem. Phys. 69: p. 4526-4534 1978. 29. Kihara, H., K. Hon-nami, and T. Kitagawa, Alkaline isomerization of thermoresistant cytochrome c-552 and horse heart cytochrome c studied by absorption and resonance Raman spectra. Biochim. Biophys. Acta 532: p. 337-346 1978. 30. Kitagawa, T., M. Abe, and H. Ogoshi, Resonance Raman spectra of octaethylporphyrinato-Ni(II) and meso-deuterated and 15N substituted derivatives. I. Observation and assignments of non-fundamental Raman lines. J. Chem. Phys. 69: p. 4516-4526 1978. 31. Kitagawa, T., T. Azuma, and K. Hamaguchi, The Raman spectra of Bence-Jones proteins. Disulfide stretching frequencies and dependence of Raman intensity of tryptophan residues upon their environments. Biopolymers 18: p. 451-465 1978. 32. Kitagawa, T. and Y. Orii, The resonance raman studies of cytochrome oxidase. J. Biochem. (Tokyo) 84: p. 1245-1252 1978. Nishina, Y., T. Kitagawa, K.Shiga, K. Horiike, Y. Matsumura, H. Watari, and T. Yamano, Resonance Raman spectra of riboflavin and its derivatives in the bound state with egg riboflavin binding proteins. J. Biochem. (Tokyo) 84: p. 33. 34. Okabayashi, H. and T. Kitagawa, Assignments of the ch-stretching raman lines of hydrocarbon chains. Raman spectra of normal C n-1H2n-1COOK (n = 3, 4, 6, 8, 10, 12, 14, 16, and 18) and their specifically deuterated derivatives. J. Phys. Chem. 82: p. 1830-1836 1978. 35. Ozaki, Y., T. Kitagawa, Y. Kyogoku, Y. Imai, C. Hashimoto-Yutsudo, and R. Sato, Resonance Raman studies of hepatic microsomal cytochrome P-450's: Evidence for strong π basicity of the fifth ligand in the reduced and co complex forms. Biochemistry 17: p. 5826-5831 1978. 36. Tatsuno, Y., Y. Saeki, M. Iwaki, T. Yagi, M. Nozaki, T. Kitagawa, and S. Otsuka, Resonance Raman spectra of protocatechuate 3,4-dioxygenase. Evidence for coordination of tyrosine residue to ferric iron. J. Am. Chem. Soc. 100: p. 4614-4615 1978. 37. Kitagawa, T. and K. Nagai, Quaternary structure-induced photoreduction of haem of haemoglobin. Nature (London) 281: p. 503-504 1979. 38. Kitagawa, T., K. Nagai, and M. Tsubaki, Assignment of the Fe-N ε (His F8) stretching band in the resonance raman spectra of deoxy-myoglobin. FEBS Lett. 104: p. 376-378 1979. 39. Kitagawa, T., Y. Nishina, Y. Kyogoku, T. Yamano, N. Ohishi, A. Takai-Suzuki, and K. Yagi, Resonance Raman spectra of ¹³C and ¹³N labelled riboflavins bound to egg-white flavoprotein. Biochemistry 18 : p. 1804-1808 1979. Kitagawa, T., Y. Nishina, K. Shiga, H. Watari, Y. Matsumura, and T. Yamano, Resonance Raman evidence for charge transfer interactions of phenols with FMN of old yellow enzyme. J. Am. Chem. Soc. 101 : p. 3376-3378 1979. 40. Kitagawa, T. and J. Teraoka, Resonance Raman spectra of intermediate-spin ferrous porphyrin. Chem. Phys. Lett. 63: p. 443-446 1979. 41. Ozaki, Y., T. Kitagawa, and H. Ogoshi, The resonance Raman spectra of metallo-trans-octaethylchlorins and their γ, δ-deuterated and 15N substituted derivatives. Inorg. Chem. 18: p. 1772-1776 1979. 42. Hon-nami, K., H. Kihara, T. Kitagawa, T. Miyazawa, and T. Ohshima, Proton nuclear-magnetic-resonance and resonance Raman studies of thermophilic cytochrome c-552 from Thermus thermophilus Hb8. Eur. J. Biochem. 110: p. 217-223 1980. 43. Hori, H. and T. Kitagawa, Iron-ligand stretching band in the resonance Raman spectra of ferrous iron porphyrin derivatives. Importance as a probe for quaternary structure of hemoglobin. J. Am. Chem. Soc. 102: p. 3608-3613 1980. 44. Kitagawa, T., Y. Fukumori, and T. Yamanaka, Resonance Raman evidence for 45. intramolecular electron transport from flavin to heme in flavocytochrome c and nature of chromophoric interactions. Biochemistry 19: p. 5721-5729 1980. 46. Kitagawa, T. and M. Tsuda, Resonance Raman spectra of acid and alkaline metarhodopsin of octopus. Biochim. Biophys. Acta 624: p. 211-217 1980. 47. Nagai, K., Y. Enoki, and T. Kitagawa, Influence of quaternary structure on the state of the heme in carp and human met-hemoglobins studied by resonance Raman scattering. Biochim. Biophys. Acta 624: p. 304-315 1980. 48. Nagai, K. and T. Kitagawa, Difference in Fe(II)-N s (His-f8) stretching frequencies between deoxyhemoglobins in the two alternative quaternary structures. Proc. Natl. Acad. Sci. U.S.A. 77: p. 2033-2037 1980. 49. Nagai, K., T. Kitagawa, and H. Morimoto, Quaternary structures and low frequency molecular vibrations of hemes of deoxy- and oxyhemoglobins studied by resonance Raman scattering. J. Mol. Biol. 136: p. 271-289 1980. 50. Nagai, K., C. Welborn, D. Dolphin, and T. Kitagawa, Resonance Raman evidence for cleavage of the Fe-N s (His f8) bond in the α subunit of the T-structure nitrosyl hemoglobin. Biochemistry 19: p. 4755-4761 1980. 51. Nishina, Y., T. Kitagawa, K. Shiga, H. Watari, and T. Yamano, Resonance Raman study of flavoenzyme-inhibitor charge-transfer interactions: Old yellow enzyme-phenol complexes. J. Biochem. (Tokyo) 87: p. 831-839 1980. 52. Teraoka, J. and T. Kitagawa, Raman characterization of axial ligands for penta- and hexa-coordinate ferric high- and intermediate-spin octaethylporphyrinato-Fe(III) complexes: Elucidation of unusual resonance Raman spectra of cytochrome c'. J. Phys. Chem. 84: p. 1928-1935 1980. 53. Teraoka, J. and T. Kitagawa, Resonance Raman study of the heme-linked ionization in reduced horseradish peroxidase. Biochem. Biophys. Res. Commun. 93: p. 694-700 1980. 54. Tsubaki, M., K. Nagai, and T. Kitagawa, Resonance Raman spectra of myoglobins reconstituted with spirographis and isospirographis hemes and 2,4-diformyl iron protoporphyrin ix: Effect of formyl substitution at heme periphery. Biochemistry 19: p. 379-385 1980. 55. Kimura, S., I. Yamazaki, and T. Kitagawa, Unusual low-frequency resonance Raman spectra of heme observed for hog intestinal peroxidase and its derivatives. Biochemistry 20: p. 4632-4637 1981. Shimizu, T., T. Kitagawa, F. Mitani, T. Iizuka, and T. Ishimura, Resonance Raman spectra of adrenal cortex cytochrome P-450scc. Biochim. Biophys. Acta 670: p. 236-242 1981. 56. Teraoka, J. and T. Kitagawa, Structural implication of the heme-linked ionization of horseradish peroxidase probed by the fe-histidine stretching 57. Raman line. J. Biol. Chem. 256: p. 3969-3977 1981. 58. Kitagawa, T., M.R. Ondrias, D.L. Rousseau, M. Ikeda-Saito, and T. Yonetani, Evidence for hydrogen bonding of bound dioxygen to the distal histidine of oxycobalt myoglobin and haemoglobin. Nature (London) 298: p. 869-871 1982. 59. Kitagawa, T., H. Sakamoto, T. Sugiyama, and T. Yamano, Formation of the semiquinone form in the anaerobic reduction of adrenodoxin reductase by NADPH. Resonance Raman, ESR, and optical spectroscopic evidence. J. Biol. Chem. 257: p. 12075-12080 1982. 60. Kitagawa, T., T. Sugiyama, and T. Yamano, Difference in stability against thermal unfolding between trypsin- and detergent-solubilized cytochrome b 5 and structural changes in the heme vicinity upon the transition: Resonance Raman and absorption study. Biochemistry 21 : p. 1680-1686 1982. 61. Okabayashi, H., Y. Yoshida, T. Ikeda, H. Matsuura, and T. Kitagawa, PO 21 symmetric stretching Raman line and molecular aggregation states of barium dialkyl phosphates. J. Am. Chem. Soc. 104: p. 5399-5402 1982. 62. Ondrias, M.R., D.L. Rousseau, T. Kitagawa, M. Ikeda-Saito, T. Inubushi, and T. Yonetani, Quaternary structure changes in iron-cobalt hybrid hemoglobins detected by resonance Raman scattering. J. Biol. Chem. 257: p. 8766-8770 1982. 63. Teraoka, J., T. Ogura, and T. Kitagawa, Resonance Raman spectra of the reaction intermediates of horseradish peroxidase catalysis. J. Am. Chem. Soc. 104: p. 7354-7356 1982. 64. Kitagawa, T., S. Hashimoto, J. Teraoka, S. Nakamura, H. Yajima, and T. Hosoya, Distinct heme-substrate interactions of lactoperoxidase probed by resonance Raman spectroscopy: Difference between animal and plant peroxidases. Biochemistry 22: p. 2788-2792 1983. 65. Nagai, K., T. Kagimoto, A. Hayashi, F. Taketa, and T. Kitagawa, Resonance Raman studies of hemoglobins M: Evidence for fe-tyrosine charge transfer interactions in the abnormal subunits of Hb M Boston and Hb M Iwate. Biochemistry 22: p. 1305-1311 1983. 66. Ogura, T., K. Honnami, T. Ohshima, S. Yoshikawa, and T. Kitagawa, Iron-histidine stretching Raman lines of the aa3-type cytochrome oxidase. J. Am. Chem. Soc. 105: p. 7781-7783 1983. 67. Teraoka, J., D. Job, Y. Morita, and T. Kitagawa, Resonance Raman study of plant tissue peroxidases: Common characteristics in iron coordination environments. Biochim. Biophys. Acta 747: p. 10-15 1983. Hashimoto, S., T. Tatsuno, and T. Kitagawa, Resonance Raman evidence for the presence of the Fe(IV)=O bond in horseradish peroxidase compound II. 68. Proc. Japan Acad. Ser. B 60: p. 345-348 1984. 69. Kamogawa, K., K. Tajima, K. Hayakawa, and T. Kitagawa, Raman spectroscopic studies of submillimolar surfactant solutions; concentration dependence of the C-H stretching Raman lines. J. Phys. Chem. 88: p. 2494-2497 1984. 70. Kitagawa, T., S. Chihara, K. Fushitani, and H. Morimoto, Resonance Raman study of subunit assembly dependent photoreduction of heme of extracellular giant hemoglobin. J. Am. Chem. Soc. 106: p. 1860-1862 1984. 71. Ogura, T., N. Sone, K. Tagawa, and T. Kitagawa, Resonance Raman study of an aa3-type cytochrome oxidase of thermophilic bacterium. Biochemistry 23: p. 2826-2831 1984. 72. Yoshikawa, S., H. Mochizuki, S. Chihara, B. Hagihara, and T. Kitagawa, Determination of the effects of the Mq²+ ion on the O 2 affinity of chlorocruorin by resonance Raman spectroscopy. Biochim. Biophys. Acta 786: p. 267-270 1984. 73. Kamogawa, K. and T. Kitagawa, Solute/solvent and solvent/solvent interactions in methanol solutions: Quantitative separation by Raman difference spectroscopy. J. Phys. Chem. 89: p. 1531-1537 1985. Maeda, A., T. Ogurusu, T. Yoshizawa, and T. Kitagawa, Resonance Raman study on binding of chloride to the chromophore of halorhodopsin. Biochemistry 24: p. 2517-2521 1985. 74. Matsukawa, S., K. Mawatari, Y. Yoneyama, and T. Kitagawa, Correlation between the iron-histidine stretching frequencies and oxygen affinity of hemoglobins; a continuous strain model. J. Am. Chem. Soc. 107: p. 1108-1113 1985. 75. Ogura, T., S. Yoshikawa, and T. Kitagawa, Resonance Raman study on photoreduction of cytochrome c oxidase; distinction of the a- and a3-hemes in the intermediates. Biochemistry 24: p. 7746-7752 1985. 76. Ogura, T., S. Yoshikawa, and T. Kitagawa, Resonance Raman spectra of oxygenated intermediates of cytochrome c oxidase detected with a mixed flow transient raman apparatus. Biochim. Biophys. Acta 832: p. 220-223 1985. 77. Abe, M., Y. Kyogoku, T. Kitagawa, K. Kawano, N. Ohishi, A. Takai-Suzuki, and K. Yagi, Vibrational analysis of flavin derivatives. Part I. Infrared spectra and molecular association of lumiflavin and riboflavin derivatives. Spectrochim. Acta 42A: p. 1059-1068 1986. 78. Hashimoto, S., R. Nakajima, I. Yamazaki, Y. Tatsuno, and T. Kitagawa, Oxygen exchange between the Fe(IV)=O heme and bulk water for the A 2 isozyme of horseradish peroxidase. FEBS Lett. 208: p. 305-307 1986. 79. Hashimoto, S., Y. Tatsuno, and T. Kitagawa, Resonance Raman evidence for oxygen-exchange between the Feiv=O heme of compound ii of horseradish peroxidase and bulk water and its relation with the heme-linked ionization. Proc. Natl. Acad. Sci. U.S.A. 83: p. 2417-2421 1986. 80. Hashimoto, S., J. Teraoka, T. Inubushi, T. Yonetani, and T. Kitagawa, Resonance Raman study on cytochrome c peroxidase and its intermediate; presence of the Fe™=O bond in compound es and heme-linked ionization. J. Biol. Chem. 261: p. 1110-11118 1986. 81. Kamogawa, K. and T. Kitagawa, Raman difference spectroscopy of the C-H stretching vibrations: Frequency shifts and excess quantities for acetone/water and acetonitrile/water solutions. J. Phys. Chem. 90: p. 1077-1081 1986. 82. Lee, H., M. Abe, R.K. Pandey, H.-K. Leung, K.M. Smith, and T. Kitagawa, Charactrerization of low frequency resonance Raman bands of metallo-protoporphyrin ix: Observation of isotope shifts and normal coordinate treatments. J. Mol. Struct. 146 p. 329-347 1986. 83. Lee, H. and T. Kitagawa, Tautomeric equilibrium of salicylidene Schiff base: UV-visible absorption and raman spectroscopic studies. Bull. Chem. Soc. Jpn. 59: p. 2897-2898 1986. 84. Maeda, A., T. Ogura, and T. Kitagawa, Resonance Raman study on proton-dissociated state of bacteriorhodopsin: Stabilization of I-like intermediate having the all-trans chromophore. Biochemistry 25: p. 2798-2803 1986. 85. Ozaki, Y., K. Iriyama, H. Ogoshi, T. Ochiai, and T. Kitagawa, Resonance Raman characterization of iron-chlorin complexes having various spin-. oxidation- and ligation-states. I: Comparative study with corresponding iron-porphyrin complexes. J. Phys. Chem. 90: p. 6105-6112 1986. 86. Ozaki, Y., K. Iriyama, H. Ogoshi, T. Ochiai, and T. Kitagawa, Resonance raman characterization of iron-chlorin complexes having various spin-, oxidation-, and ligation-states. II: Low frequency skeletal vibrations and Fe-ligand stretching modes. J. Phys. Chem. 90: p. 6113-6118 1986. 87. Shibayama, N., H. Morimoto, and T. Kitagawa, The properties of chemically modified Ni(II)-Fe(II) hybrid hemoglobins: Ni(II) protoporphyrin ix as a model for a permanent deoxy-heme. J. Mol. Biol. 192: p. 331-336 1986. 88. Sone, N., T. Ogura, and T. Kitagawa, Iron-histidine stretching Raman line and enzymic activities of beef- and bacterium cytochrome c oxidases. Biochim. Biophys. Acta 850: p. 139-145 1986. 89. Sugihara, T. and T. Kitagawa, Resonance Raman study of red-shifted retinal schiff-base. Bull. Chem. Soc. Jpn. 59: p. 2929-2931 1986. 90. Ozaki, Y., K. Iriyama, H. Ogoshi, and T. Kitagawa, Ligand-aided 91. photoreduction of iron-porphyrin complexes probed by resonance Raman spectroscopy. J. Am. Chem. Soc. 109: p. 5583-5586 1987. Teraoka, J., S. Hashimoto, H. Sugimoto, M. Mori, and T. Kitagawa, Resonance Raman characterization of highly reduced iron porphyrins. J. Am. Chem. Soc. 109: p. 180-184 1987. 92. Fujii, T., K. Kamogawa, and T. Kitagawa, Observation of resonance Raman spectra of S 1 -, T 1 - and S 0 -pyrene in solution: Application of a fluorescence rejection technique. Chem. Phys. Lett. 148: p. 17-20 1988. 93. Groot, J.d., R.E. Hester, S. Kaminaka, and T. Kitagawa, Functional activity of haemoglobins adsorbed on colloidal silver: A SERRS study. J. Phys. Chem. 92: p. 2044-2048 1988. 94. Hosoi, J., J. Utsumi, and T. Kitagawa, Structural characterization of fibroblast human interferon- β 1 . J. Interferon Res. 8: p. 375-384 1988. 95. Ogura, T. and T. Kitagawa, A novel optical device for simultaneous measurements of Raman and absorption spectra: Application to photolabile reaction intermediates of hemeproteins. Rev. Sci. Instrum. 59: p. 1316-1320 1988. 96. Verma, A.L., K. Kimura, A. Nakamura, T. Yagi, H. Inokuchi, and T. Kitagawa, Resonance Raman studies of hydrogenase-catalyzed reduction of cytochrome c 3 by hydrogen; evidence for heme-heme interactions. J. Am. Chem. Soc. 110: p. 6617-6623 1988. 97. Anzenbacher, P., J.H. Dawson, and T. Kitagawa, Towards a unified concept of oxygen activation by heme enzymes: The role of the proximal ligand. J. Mol. Struct. 214: p. 149-158 1989. 98. Hashimoto, S., R. Nakajima, I. Yamazaki, T. Kotani, S. Ohtaki, and T. Kitagawa, Resonance Raman characterization of hog thyroid peroxidase: A SERRS study. FEBS Lett. 248: p. 205-209 1989. 99. Kaminaka, S., T. Ogura, K. Kitagishi, T. Yonetani, and T. Kitagawa, Resonance Raman spectra of intermediate ligated forms of hemoglobin: The Vie-his, Vie-co, δίeco, and voo modes of cross-linked Fe-Co hybrid hemoglobins. J. Am. Chem. Soc. 111: p. 3787-3794 1989. 100. Khulbe, P.K., A. Agarwal, G.S. Raghuvanshi, H.D. Bist, S. Hashimoto, T. Kitagawa, T.S. Little, and J.R. Durig, Raman studies of the vibrational dynamics and phase transitions in uranyl nitrate hexahydrate. J. Raman Spectrosc. 20: p. 283-290 1989. 101. Nagai, M., Y. Yoneyama, and T. Kitagawa, Characteristics in tyrosine coordination of four hemoglobins M probed by resonance Raman spectroscopy. Biochemistry 28 : p. 2418-2422 1989. 102. Nakagawa, M., A. Maeda, T. Ogura, and T. Kitagawa, Origin of Raman spectral difference between the spinning-cell and flow-cell measurements for bacteriorhodopsin photointermediates. J. Raman Spectrosc. 20: p. 303-305 1989. 103. Nakagawa, M., T. Ogura, A. Maeda, and T. Kitagawa, Transient resonance Raman spectra of neutral and alkaline bacteriorhodopsin photointermediates by using double-beam apparatus: Presence of very fast decaying M412 . Biochemistry 28: p. 1347-1352 1989. 104. Ogura, T., S. Yoshikawa, and T. Kitagawa, Raman/absorption simultaneous measurements for cytochrome oxidase compound a at room temperature with a novel flow apparatus. Biochemistry 28: p. 8022-8027 1989. 105. Ozaki, Y., K. Aoyagi, K. Iriyama, H. Ogoshi, and T. Kitagawa, Resonance Raman characteristics of N-methyl-octaethylporphyrinato-cobalt(II). J. Phys. Chem. 93: p. 3842-3847 1989. 106. Verma, A.L., K. Kimura, T. Yagi, A. Nakamura, H. Inokuchi, and T. Kitagawa, SERR evidence for enzymic reduction of cytochrome c3 adsorbed on Ag colloids. Chem. Phys. Lett. 159: p. 189-192 1989. 107. Egawa, T., Y. Imai, T. Ogura, and T. Kitagawa, Resonance Raman study on mutant cytochrome P-450 obtained by site directed mutagenesis. Biochim. Biophys. Acta 1040: p. 211-216 1990. 108. Egawa, T., Y. Imai, T. Ogura, and T. Kitagawa, Resonance Raman study on mutant cytochrome P-450 obtained by site directed mutagenesis. Biochim. Biophys. Acta 1040: p. 211-216 1990. 109. Kaminaka, S., T. Ogura, and T. Kitagawa, Time-resolved ultraviolet resonance Raman study of the photolysis of carbonmonoxy hemoglobin: Relaxation of the globin structure. J. Am. Chem. Soc. 112: p. 23-27 1990. 110. Kamogawa, K. and T. Kitagawa, A new device for Raman difference spectroscopy and its application to observe frequency shifts due to isotope mixing. J. Phys. Chem. 94: p. 3916-3921 1990. 111. Kitajima, N., H. Fukui, Y. Moro-oka, Y. Mizutani, and T. Kitagawa, A synthetic model for dioxygen binding site of non-heme proteins. X-ray structure of Fe(Obz)(MeCN)[HB(3,5-iPr²Pz)³] and resonance Raman evidence for reversible formation of peroxo adduct. J. Am. Chem. Soc. 112: p. 6402-6403 1990. 112. Mizutani, Y., S. Hashimto, T. Tatsuno, and T. Kitagawa, Resonance Raman purisuit of the change from Fe'i-O 2 to Fe'ii-OH via Fe'v=O in autoxidation of ferrous iron-porphyrin. J. Am. Chem. Soc. 112: p. 6809-6814 1990. 113. Ogura, T., V. Fidler, Y. Ozaki, and T. Kitagawa, Alcohol catalyzed photoreduction of iron porphyrin complexes revealed by resonance Raman 114. and absorption spectroscopies. Chem. Phys. Lett. 169: p. 457-459 1990. 115. Ogura, T., S. Takahashi, K. Shinzawa, S. Yoshikawa, and T. Kitagawa, Observation of the Feil-O 2 stretching raman band for compound a of cytochrome oxidase at room temperature. J. Am. Chem. Soc. 112: p. 5630-5631 1990. 116. Ogura, T., S. Takahashi, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Observation of the Fe 4+=O stretching Raman band for cytochrome oxidase compound b at ambient temperature.    1990. 117. Tokutomi, S., Y. Mizutani, E. Anni, and T. Kitagawa, Resonance Raman scattering from large pea phytochrome at ambient temperature: Difference in chromophore protonation between red- and far-red light absorbing forms. FEBS Lett. 269: p. 341-344 1990. 118. Egawa, T., T. Ogura, R. Makino, Y. Ishimura, and T. Kitagawa, Observation of the O-O stretching raman band for cytochrome P-450cam under catalytic conditions. J. Biol. Chem. 266: p. 10246-10248 1991. 119. Fidler, V., T. Ogura, S. Sato, K. Aoyagi, and T. Kitagawa, Resonance Raman study on photoreduction of iron-porphyrins: A novel insight into the ligand-aided process. Bull. Chem. Soc. Jpn. 64: p. 2315-2322 1991. 120. Hashimoto, S., Y. Mizutani, Y. Tatsuno, and T. Kitagawa, Resonance Raman characterization of ferric- and ferrylporphyrin π cation radicals and the Feiv=O stretching frequency. J. Am. Chem. Soc. 113: p. 6542-6549 1991. 121. Imai, K., K. Fushitani, G. Miyazaki, K. Ishimori, T. Kitagawa, Y. Wada, H. Morimoto, I. Morishima, D.T.-b. Shih, and J. Tame, Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42(c7)α at the α1-β2 interface. J. Mol. Biol. 218: p. 769-778 1991. 122. Kamogawa, K. and T. Kitagawa, Evidence for direct intermolecular interactions as an origin of the hydration shifts of the C-H stretching vibrations; 1.4-dioxane/water system. Chem. Phys. Lett. 179: p. 271-276 1991. 123. Kitajima, N., T. Koda, S. Hashimoto, T. Kitagawa, and Y. Moro-oka, Synthesis and characterization of the dinuclear copper(II) complexes [Cu(HB(3,5-Me 2 Pz) 3 )] 2 X (X = O 2 -, (OH) 2 2 -, CO 3 2 -, O 2 2 -). J. Am. Chem. Soc. 113: p. 5664-5671 1991. 124. Mizutani, Y., K. Kamogawa, T. Kitagawa, A. Shimizu, Y. Taniguchi, and K. Nakanishi, Solution structures and phase separation in fluoroalcohol/water mixtures; a study with Raman difference and 13C NMR spectroscopy. J. Phys. Chem. 95: p. 1790-1794 1991. 125. Mizutani, Y., S. Tokutomi, K. Aoyagi, K. Horitsu, and T. Kitagawa, Resonance Raman study on intact pea phytochrome and its model compounds: Evidence for proton migration during the phototransformation. Biochemistry 30: p. 10693-10700 1991. Nagai, M., Y. Yoneyama, and T. Kitagawa, Unusual CO binding geometry in abnormal subunits of hemoglobin M Boston and Hb M Saskatoon. Biochemistry 30: p. 6495-6503 1991. 126. Nakagawa, M., A. Maeda, T. Ogura, and T. Kitagawa, Identification of the long-lived I' species of bacteriorhodopsin to the n intermediate by Raman/absorption quasi-simultaneous measurements. J. Mol. Struct. 242 : p. 221-234 1991. 127. Ogura, T., S. Takahashi, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Time-resolved resonance Raman investigation of cytochrome oxidase catalysis: Observation of a new oxygen-isotope sensitive Raman band. Bull. Chem. Soc. Jpn. 64: p. 2901-2907 1991. 128. Takahashi, S., T. Ogura, K. Itoh-Shinzawa, S. Yoshikawa, and T. Kitagawa, Observation of the Ču a -ligand stretching resonance raman band for cytochrome c oxidase. J. Am. Chem. Soc. Vol. 113. 1991. 9400-9401. 129. Egawa, T., H. Miki, T. Ogura, R. Makino, Y. Ishimura, and T. Kitagawa, Observation of the FeivO stretching Raman band for a thiolate-ligated heme protein; compound i of chloroperoxidase. FEBS Lett. 305: p. 206-208 1992. 130. Hayashi, Y., M. Suzuki, A. Uehara, Y. Mizutani, and T. Kitagawa, (μ-alkoxo)diiron(II,II) complexes of n,n',n'-tetrakis(2-(6-methylpyridyl)methyl)-1,3-diamino propane-2-olate and the reversible formation of the O 2 adducts. Chem. Lett.: p. 91-94 1992. 131. Ishimori, K., K. Imai, G. Miyazaki, T. Kitagawa, Y. Wada, H. Morimoto, and I. Morishima, Site-directed mutagenesis in hemoglobin: Functional and structural role of inter- and intrasubunit hydrogen bonds as studied with 37ß and 145ß mutations. Biochemistry 31 : p. 3256-3265 1992. 132. Kaminaka, S. and T. Kitagawa, Time-resolved UV resonance Raman study on Bohr effects of hemoglobin. J. Am. Chem. Soc. 114: p. 3256-3260 1992. 133. Kaminaka, S. and T. Kitagawa, A novel idea for practical UV resonance Raman measurement with a double-monochromator and its application to protein structural studies. Appl. Spectrosc. 46: p. 1804-1808 1992. 134. Kaminaka, S., H. Takizawa, T. Handa, H. Kihara, and T. Kitagawa, Resonance Raman study on active site structure of an cooperative hemerythrin. Biochemistry 31 : p. 6997-7002 1992. 135. Kitajima, N., K. Fujiwara, C. Fujimoto, Y. Moro-oka, S. Hashimoto, T. Kitagawa, K. Toriumi, K. Tatsumi, and A. Nakamura, A new model for dioxygen binding in hemocyanin. Synthesis, characterization, and molecular structure of the µ-η²:H² peroxo dinuclear copper(II) complexes, [Cu(HB(3,5-R²pz)³)]²(O²) (R = i-Pr and Ph). J. Am. Chem. Soc. 114: p. 1277-1291 1992. 136. 137. Sakan, Y., T. Ogura, and T. Kitagawa, Detection of the Fe-CO stretching Raman band for recombination transient species of photodissociated carbon monoxy myoglobin by using pump/probe time-resolved technique. Chem. Phys. Lett. 196: p. 150-154 1992. 138. Sato, S., M. Asano-Someda, and T. Kitagawa, Time-resolved resonance raman spectra of free-base octaethylporphyin in the S 1 and T 1 states. Chem. Phys. Lett. 189: p. 443-447 1992. 139. Sato, S., K. Kamogawa, K. Aoyagi, and T. Kitagawa, Time-resolved resonance Raman investigation of photoreduction of iron-octaethylporphyrin complexes by using quasi-simultaneous pump/probe measurement technique. J. Phys. Chem. 96: p. 10676-10681 1992. 140. Adachi, S., S. Nagano, K. Ishimori, Y. Watanabe, I. Morishima, T. Egawa, T. Kitagawa, and R. Makino, Role of proximal ligand in heme proteins: Replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450, chloroperoxidase, and catalase. Biochemistry 32: p. 241-252 1993. 141. Lian, T., B. Locke, T. Kitagawa, M. Nagai, and R.M. Hochstrasser, Determination of Fe-CO geometry in the subunits of carbonmonoxy hemoglobin M Boston using femtosecond infrared spectroscopy. Biochemistry 32: p. 5809-5814 1993. 142. Mizutani, Y., S. Tokutomi, S. Kaminaka, and T. Kitagawa, Ultraviolet resonance Raman spectra of pea intact, large, and small phytochromes: Differences in molecular topography of the red and far-red absorbing forms. Biochemistry 32: p. 6916-6922 1993. 143. Ogura, T., S. Takahashi, S. Hirota, K. Shinzawa-Itoh, S. Yoshikawa, E.H. Appelman, and T. Kitagawa, Time-resolved resonance Raman elucidation of the pathway for dioxygen reduction by cytochrome c oxidase. J. Am. Chem. Soc. 115: p. 8527-8536 1993. 144. Sakan, Y., T. Ogura, T..Kitagawa, F.A. Fraunfelter, R. Mattera, and M. Ikeda-Saito, Time-resolved resonance Raman study on the binding of carbonmonoxide to recombinant human myoglobin and its distal histidine mutants. Biochemistry 32: p. 5815-5824 1993. 145. Takahashi, S., J.S. Ahn, S. Asaka, and T. Kitagawa, Multichannel fourier transform spectroscopy using two-dimensional detection of interferogram and its application to Raman spectroscopy. Appl. Spectrosc. 47: p. 863-868 1993. 146. Takahashi, S., T. Ogura, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Resonance Raman studies on the Cu a site of cytochrome c oxidase using a multichannel scanning Raman spectrometer with a CCD detector. Biochemistry 32: p. 3664-3670 1993. 147. Yumoto, I., S. Takahashi, T. Kitagawa, Y. Fukumori, and T. Yamanaka, The molecular features and catalytic activity of Cu a -containing aco 3 -type cytochrome c oxidase from a facultative Akalophilic bacillus. J. Biochem. (Tokyo) 114: p. 88-95 1993. 148. Hirota, S., T. Mogi, T. Ogura, T. Hirano, Y. Anraku, and T. Kitagawa, Observation of the Fe-O 2 and Fe v =O stretching raman bands for dioxygen reduction intermediates of cytochrome bo isolated from Escherichia coli. FEBS Lett. 352: p. 67-70 1994. 149. Hirota, S., T. Ogura, E.H. Appelman, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Observation of a new oxygen-isotope-sensitive Raman band for oxyhemoproteins and its implications in heme pocket structures. J. Am. Chem. Soc. 116: p. 10564-10572 1994. 150. Hirota, S., T. Ogura, K. Shinzawa-Itoh, S. Yoshikawa, M. Nagai, and T. Kitagawa, Vibrational assignments of the FeCO unit of CO-bound heme proteins revisited: Observation of a new CO-isotope-sensitive Raman band assignable to the FeCO bending fundamental. J. Phys. Chem. 98: p. 6652-6660 1994. 151. Isobe, K., Y. Ozawa, A.V.d. Miguel, T.-W. Zhu, K.-M. Zhao, T. Nishioka, T. Ogura, and T. Kitagawa, [{Rh²Cp*(μ-CH²)²}²(μ-S4)P*:    A novel tetranuclear cationic complex with a rectangular S 4 unit. Angew. Chem. INt. Ed. Engl. 33: p. 1882-1883 1994. 152. Jewsbury, P. and T. Kitagawa, The distal redidue-CO interaction in carbonmonoxy myoglobins:    A molecular dynamics study of two distal histidine tautomers. Biophys. J. 67: p. 2236-2250 1994. 153. Jewsbury, P., S. Yamamoto, T. Minato, M. Saito, and T. Kitagawa, The proximal residue largely determine the CO orientation in carbonmonoxy globin proteins. An ab initio study of a haem prosthetic unit. J. Am. Chem. Soc. 116: p. 11586-11587 1994. 154. Kaminaka, S., Y.-X. Zhou, A. Tsuneshige, T. Yonetani, and T. Kitagawa, Sequential changes of the Fe-histidine bond upon ligand binding to hemoglobins: Resonance Raman study of αα-crosslinked Co-Fe hybrid Hbs. J. Am. Chem. Soc. 116: p. 1683-1689 1994. 155. Kamogawa, K., M. Takamura, H. Matsuura, and T. Kitagawa, A multi-reflection Raman cell for studying dilute aqueous solutions. Spectrochim. Acta 50A: p. 1513-1519 1994. 156. Kitajima, N., N. Tamura, H. Amagai, H. Fukui, Y. Moro-oka, Y. Mizutani, T. Kitagawa, R. Methur, K. Heerwegh, C.A. Reed, C.R. Randall, J. L. Que, and K. Tatsumi, Monomeric carboxylate ferrous complexes as models for the dioxygen binding sites in non-heme iron proteins.    The reversible formation and characterization of μ-peroxo diferric complexes. J. Am. Chem. SOc. 116: p. 9071-9085 1994. 157. Mizutani, Y., S. Tokutomi, and T. Kitagawa, Resonance Raman spectra of the intermediates in phototransformation of large phytochrome: Deprotonation of the chromophore in the bleached intermediate. Biochemistry 33: p. 153-158 1994. 158. Mizutani, Y., Y. Watanabe, and T. Kitagawa, Resonance Raman characterization of iron(III) porphyrin N-oxide: Evidence for an Fe-O-N bridged structure. J. Am. Chem. Soc. 116: p. 3439-3441 1994. 159. Nakashima, S. and T. Kitagawa, Recombination intermediates of photodissociated CO myoglobin at ambient temperatures detected by time-resolved resonance Raman spectroscopy. J. Am. Chem. Soc. 116: p. 10318-10319 1994. 160. Ozawa, S., Y. Watanabe, S. Nakashima, T. Kitagawa, and I. Morishima, Preparation and characterization of oxoiron(IV) chlorin complexes as the first models for a reaction intermediate in the catalytic cycle of cytochrome d. J. Am. Chem. Soc. 116: p. 634-641 1994. 161. Proshlyakov, D.A., T. Ogura, K. Shinzawa-Itoh, S. Yoshikawa, E.H. Appelman, and T. Kitagawa, Selective resonance Raman observation of the "607 nm" form generated in the reaction of oxidized cytochrome c   oxidase with hydrogen peroxide. J. Biol. Chem. 269: p. 29385-29388 1994. 162. Sato-Watanabe, M., T. Mogi, T. Ogura, T. Kitagawa, H. Miyoshi, H. Iwamura, and Y. Anraku, Indentification of novel quinone-binding site in the cytochrome complex from Escherichia coli. J. Biol. Chem. 269: p. 28908-28912 1994. bo 163. Shiro, Y., T. Iizuka, K. Marubayashi, T. Ogura, T. Kitagawa, S. Balasubramanian, and S.G. Boxer, Spectroscopic study of Ser92 mutants of human myoglobin:   Hydrogen bonding effect of Ser92 to proximal His93 on structure and property of myoglobin. Biochemistry 33: p. 14986-14992 1994. 164. Sone, N., T. Ogura, S. Noguchi, and T. Kitagawa, Proton pumping activity and visible absorption and resonance Raman spectra of a cao-type cytochrome c oxidase isolated from thermophilic bacterium bacillus PS3. Biochemistry 33 : p. 849-855 1994. 165. Tsubaki, M., T. Mogi, H. Hori, S. Hirota, T. Ogura, T. Kitagawa, and Y. Anraku, Molecular structure of redox metal centers of the cytochrome bo   complex from Escherichia coli :    Spectroscopic characterizations of the subunit I histidine mutant oxidases. J. Biol. Chem. 269: p. 30861-30868 1994. 166. Ahn, J.S., T. Kitagawa, Y. Kanematsu, Y. Nishikawa, and T. Kushida, Glass transition of Zn-substituted myoglobin probed by absorption and site-selective fluorescence spectroscopies. J. Lumin. 64: p. 81-86 1995. 167. Asano-Someda, M., S. Sato, K. Aoyagi, and T. Kitagawa, Time-resolved resonance Raman spectra of meso-substituted copper porphyrins in the T 1 state: Implication for the solvent dependent red-shift of emission spectra. J. Phys. Chem. 99: p. 13800-13807 1995. 168. Hayashi, Y., T. Kayatani, H. Sugimoto, M. Suzuki, A. Uehara, Y. Mizutani, T. Kitagawa, and Y. Maeda, Synthesis, characterization, and reversible oxygenation of μ -alkoxo-diiron(II) complexes with a dinucleating ligand, n, n, n'. n'-tetrakis{2-(6-methylpyridyl)methyl}-1,3-diaminopropan-2-olate. J. Am. Chem. Soc. 117: p. 11220-11229 1995. 169. Hirota, S., T. Mogi, Y. Anraku, R.B. Gennis, and T. Kitagawa, Resonance Raman study on axial ligands of heme irons in cytochrome bd-type ubiquinol oxidase from escherichia coli. Biospectroscopy 1: p. 305-311 1995. 170. Hirota, S., T. Ogura, and T. Kitagawa, Observation of nonfundamental Fe=O 2 and Fe-CO vibrations and potential anharmonicities for oxyhemoglobin and carbonmonoxyhemoglobin; evidence supporting a new assignment of the Fe-C-O bending fundamental. J. Am. Chem. Soc. 117: p. 821-822 1995. 171. Jewsbury, P. and T. Kitagawa, The distal-CO interaction in carbonmnooxy myoglobins: The molecular dynamics of 3 distal mutants. Biophys. J. 68: p. 1283-1294 1995. 172. Jewsbury, P., S. Yamamoto, T. Minato, M. Saito, and T. Kitagawa, The proximal residue largely determines the co distortion in carbon monoxy globin proteins.    An ab initio study of a heme prosthetic unit. J. Phys. Chem. 99: p. 12677-12685 1995. 173. Kaminaka, S. and T. Kitagawa, A novel spinning cell system for UVRR measurements of power- and small volume solution samples in back-scattering geometry:    Application to solid tryptophan and mutant hemoglobin solution. Appl. Spectrosc. 49: p. 685-687 1995. 174. Kohzuma, T., C. Dennison, W. McFarlane, S. Nakashima, T. Kitagawa, T. Inoue, Y. Kai, N. Nishio, S. Shidara, S. Suzuki, and A.G. Sykes, Spectroscopic and electrochemical studies on active-site transitions of the type 1 copper protein pseudoazurin from achromobacter cycloclastes. J. Biol. Chem. 270: p. 25733-25738 1995. 175. Masatoki, S., M. Takamura, M. Matsuura, K. Kamogawa, and T. Kitagawa, Raman spectroscopic observations of anomalous conformational behavior of short poly(oxyethylene) chains in water. Chem. Lett. (81-86): p. 991-992 1995. 176. Nagai, M., S. Kaminaka, Y. Ohba, Y. Nagai, Y. Mizutani, and T. Kitagawa, Ultraviolet resonance Raman studies of quaternary structure of hemoglobin using a tryptophan β37 mutant. J. Biol. Chem. 270 : p. 1636-1642 1995. 177. Sato, S., K. Aoyagi, T. Haya, and T. Kitagawa, Time-resolved resonance Raman study of free-base octaethyl porphyrins in the s 0 , S 1 , and T 1 states. J. Phys. Chem. 99: p. 7766-7775 1995. Asano-Someda, M., K. Aoyagi, and T. Kitagawa, Time-resolved resonance raman spectra of octaethyl-porphinato copper(II) in the lowest excited triplet state. Chem. Phys. Lett. 257: p. 492-498 1996. 178. Frebort, I., P. Pec, L. Luhova, H. Toyama, K. Matsushita, S. Hirota, T. Kitagawa, T. Ueno, Y. Asano, Y. Kato, and O. Adachi, Two amine oxidases from Aspergillus niger aku 3302 contain TOPA quinone as the cofactor. Unusual cofactor link to the glutamyl residue occurs only at one of the enzymes. Biochim. Biophys. Acta 1295: p. 59-72 1996. 179. Hirota, S., T. Li, G.N.P. Jr., J.S. Olson, M. Mukai, and T. Kitagawa, Perturbation of the Fe-O 2 bond by near-by residues in heme pocket: Observation of ν ἱθ-ο₂ Raman bands for oxymyoglobin mutants. J. Am. Chem. Soc. 118: p. 7845-7846 1996. 180. Hirota, S., T. Oguara, S. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Observation of multiple CN-isotope-sensitive Raman bands for CN-adducts of hemoglobin, myoglobin, and cytochrome c oxidase;    evidence for vibrational coupling between the Fe-C-N bending and porphyrin in-plane modes. J. Phys. Chem. 100: p. 15274-15279 1996. 181. Nagai, M., K. Imai, S. Kaminaka, Y. Mizutani, and T. Kitagawa, Ultraviolet resonance Raman studies of hemoglobin quaternary structure using a tyrosine α42 mutant:    Changes of α₁β₂ subunit interface upon the T→R transition. J. Mol. Struct. 379: p. 65-75 1996. 182. 183.   Ogura, T., S. Hirota, D.A. Proshlyakov, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Time-resolved resonance Raman evidence for tight coupling between electron transfer and proton pumping of cytochrome c oxidase upon the change from the Fev oxidation level to the Fev oxidation level. J. Am. Chem. Soc. 118: p. 5443-5449 1996. Proshlyakov, D.A., T. Ogura, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Microcirculating system for simultaneous determination of Raman and absorption spectra of enzymatic reaction intermediates and its application to the reaction of cytochrome c oxidase with hydrogen peroxide. Biochemistry 35: p. 76-82 1996. 184. Proshlyakov, D.A., T. Ogura, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Resonance Raman/absorption characterization of the oxo-intermediates of cytochrome c oxidase generated in its reaction with hydrogen peroxide:   pH and H 2 O 2  concentration dependence.    Biochemistry 35: p. 8580-8586 1996. 185. Proshlyakov, D.A., I.R. Paeng, K.-J. Paeng, and T. Kitagawa, Resonance Raman studies of compounds I and II of arthromyces ramosus peroxidase: Close similarities in their raman spectra but distinct oxygen exchangeability of the Fe=O heme. Biospectroscopy 2: p. 317-329 1996. 186. Zhao, X., H. Imahori, C.-G. Zhan, Y. Mizutani, Y. Sakata, and T. Kitagawa, 187. Ultraviolet resonance Raman spectra and ab initio vibrational analysis of 1.4-benzoquinone; reassignments of the v 2 and v 3 bands. Chem. Phys. Lett 262: p. 643-648 1996. 188. Hikichi, S., H. Komatsuzaki, N. Kitajima, M. Akita, M. Mukai, T. Kitagawa, and Y. Moro-oka, Characterization of a μ-η²:ዙ-peroxo dinuclear cobalt(II) complex. Inorg. Chem. 36: p. 266-267 1997. 189. Kruglik, S.G., Y. Mizutani, and T. Kitagawa, Time-resolved resonance Raman study of the primary photo-processes of nickel(II) octaethylporphyrin in solutions. Chem. Phys. Lett. 266: p. 283-289 1997. 190. Mizutani, Y. and T. Kitagawa, Direct obervation of cooling of heme upon photodissociation of carbonmonoxy myoglobin. Science 278: p. 443-446 1997. 191. Mukai, M., S. Nagano, M. Tanaka, K. Ishimori, I. Morishima, T. Ogura, Y. Watanabe, and T. Kitagawa, Effects of concerted hydrogen bonding of distal histidine on active site structures of horseradish peroxidase; resonance Raman studies with Asn-70 mutants. J. Am. Chem. Soc. 119: p. 1758-1766 1997. 192. Tanaka, M., K. Ishimori, M. Mukai, T. Kitagawa, and I. Morishima, Catalytic activites and structural properties of horseradish peroxidase distal his42Å®glu or gln mutant. Biochemistry 36: p. 9889-9898 1997. 193. Tomita, T., T. Oguara, S. Tsuyama, Y. Imai, and T. Kitagawa, Effects of gtp on bound nitric oxide of soluble guanylate cyclase revealed by resonance raman spectroscopy. Biochemistry 36: p. 10155-10160 1997. 194. Tomita, T., S. Tsuyama, Y. Imai, and T. Kitagawa, Purification of bovine soluble guanylate cyclase and adp-ribosylation on its small subunit by bacterial toxins. J. Biochem. (Tokyo) 122: p. 531-536 1997. 195. Tsubaki, M., K. Matsushita, O. Adachi, S. Hirota, T. Kitagawa, and H. Hori, Resonance Raman, infrared and EPR investigation on the binuclear site structure of the heme-copper ubiquinol oxidases from acetobacter aceti: Effect of the heme peripheral formyl group substitution. Biochemistry 36: p. 13034-13042 1997. 196. Uesugi, Y., Y. Mizutani, and T. Kitagawa, Developments of widely tunable light sources for picosecond time-resolved resonance Raman spectroscopy. Rev. Sci. Instrum. 68: p. 4001-4008 1997. 197. Verma, A.L., S. Sato, and T. Kitagawa, Time-resolved resonance Raman evidence for the exciplex formation of free-base porphyrin with an electron acceptor. Chem. Phys. Lett. 267: p. 507-514 1997. Zhao, X., H. Imahori, C.-G. Zhan, Y. Sakata, S. Iwata, and T. Kitagawa, Resonance Raman and FTIR spectra of isotope-labeled reduced 1,4-benzoquinone and their protonated forms in solutions. J. Phys. Chem. 101 : 198. 199. Zhao, X., T. Ogura, M. Okamura, and T. Kitagawa, Observation of the resonance raman spectra of the semiquinones.    Q a   and Q b   In photosynthetic reaction centers from Rb sphaeroides R26. J. Am. Chem. Soc. 119: p. 5263-5264 1997. 200. Hirota, S., H. Matsumoto, H.-W. Huang, T. Sakurai, and T. Kitagawa, Observation of Cu-N 3  stretching and N 3 asymmetric stretching bands for mono-azide adduct of rhus vernicifera laccase. Biochem. Biophys. Res. Commun. 243: p. 435-437 1998. 201. Kodera, M., Y. Tachi, S. Hlrota, K. Katayama, H. Shimakoshi, K. Kano, K. Fujisawa, Y. Morooka, Y. Naruta, and T. Kitagawa, A superoxodicopper(II) complex oxidatively generated by a reaction of di-l-hydroxodicopper(II) complex with hydrogen peroxide. Chem. Lett.: p. 389-390 1998. 202. Kruglik, S.G., A.G. Shvedko, and T. Kitagawa, Saturation Raman spectroscopy as a tool for studying the excited states of complex organic molecules: Application to nickel octaethylporphyrin. Asian J. Phys. 7: p. 365-382 1998. 203. Mukai, M., S. Nakashima, J.S. Olson, and T. Kitagawa, Time-resolved UV resonance Raman detection of a transient open form of the ligand pathway in Tyr64(e7) myoglobin. J. Phys. Chem. 102 : p. 3624-3630 1998. 204. Nakashima, S., T. Kitagawa, and J.S. Olson, Time-resolved resonance Raman study of intermediates generated after photodissociation of wild-type and mutant CO-myoglobins. Chem. Phys. 228: p. 323-336 1998. 205. Okishio, N., R. Fukuda, M. Nagai, Y. Nagai, S. Nagatomo, and T. Kitagawa, Tyrosine phosphorylation-induced changes in absorption and UV resonance Raman spectra of SRC-peptides. J. Raman Spectrosc. 29: p. 31-39 1998. 206. Sasakawa, Y., K. Onodera, M. Karasawa, S.-C. Im, E. Suzuki, F. Yoshizaki, Y. Sugimura, N. Shibata, T. Inoue, Y. Kai, S. Nagatomo, T. Kitagawa, and T. Kouzuma, Spectroscopic characterization and kinetic studies of a novel plastocyanin from the green alga ulva pertusa. Inorg. Chim. Acta 283: p. 184-192 1998. 207. Uesugi, Y., Y. Mizutani, and T. Kitagawa, Photo-induced solvent ligation in nickel(II)-octaethylporphyrin probed by picosecond time-resolved resonance Raman spectroscopy. J. Phys. Chem. A. 102 : p. 5809-5815 1998. 208. Wada, A., M. Harata, K. Hasegawa, K. Jitsukawa, H. Masuda, M. Mukai, T. Kitagawa, and H. Einaga, Structural and spectroscopic characterization of a mononuclear hydroperoxo-copper(II) complex with tripodal pyridylamine ligands. Angew. Chem. Int. Ed. 57: p. 798-799 1998. Zhao, X. and T. Kitagawa, Solvent effects of 1,4-benzoquinone and its anion 209. radicals probed by resonance Raman and absorption spectra and their correlation with redox potentials. J. Raman Spectrosc. 29: p. 773-780 1998. Itoh, S., H. Bandoh, S. Nagatomo, T. Kitagawa, and S. Fukuzumi, Aliphatic hydroxylation by a bis( μ -oxo)dinickel(III) complex. J. Am. Chem. Soc. 121: p. 8945-8946 1999. 210. Itoh, S., M. Taki, H. Kumei, S. Takayama, S. Nagatomo, T. Kitagawa, N. Sakurada, R. Arakawa, and S. Fukuzumi, Model complexes of the active form of galactose oxidase.    Physicochemical properties and reactivity of Cu(II)- and Zn(II)-phenoxyl radical complexes of the novel organic cofactor. Angew. Chem.Intl. Ed. 38: p. 2775-2776 1999. 211. Iwase, T., C. Varotsis, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Infrared evidence for Cu ь ligation of photodissociated co of cytochrome c oxidase at ambient temperatures and accompanied deprotonation of a carboxyl side chain of protein. J. Am. Chem. Soc. 121: p. 1415-1416 1999. 212. Kaminaka, S., Y. Imamura, M. Shingu, T. Kitagawa, and T. Toyoda, Studies of bovine enterovirus structure by ultraviolet resonance Raman spectroscopy. J. Virol. Met. 77: p. 117-123 1999. 213. Kohzuma, T., T. Inoue, F. Yoshizaki, Y. Sasakawa, K. Onodera, S. Nagatomo, T. Kitagawa, S. Uzawa, Y. Isobe, Y. Sugimura, M. Gotowda, and Y. Kai, The structure and unusual pH-dependence of plastocyanin from the fern dryopteris crassirhizoma: The protonation of an active-site histidine is hindered by π-π interactions. J. Biol. Chem. 274 : p. 11817-11823 1999. 214. Mizutani, Y., Y. Uesugi, and T. Kitagawa, Intramolecular vibrational energy redistribution and intermolecular energy transfer in the (d,d) excited state of nickel octaethylporphyrin. J. Chem. Phys. 111: p. 8950-8962 1999. 215. Nagai, M., H. Wajcman, A. Lahary, T. Nakatsukasa, S. Nagatomo, and T. Kitagawa, Quaternary structure sensitive tyrosine residues in human hemoglobin: UV resonance Raman studies of mutants at α 140, β35, and β145 tyrosine. Biochemistry 38: p. 1243-1251 1999. 216. Nagatomo, S., M. Nagai, A. Tsuneshige, T. Yonetani, and T. Kitagawa, Uv Relation resonance Raman studies of α-nitrosyl hemoglobin derivatives: between the α1-β2 subunit interface interactions and the Fe-histidine bonding of α heme. Biochemistry 38: p. 9659-9666 1999. 217. Nakashima, S., S. Taniguchi, T. Okada, A. Osuka, Y. Mizutani, and T. Kitagawa, Evidence for π-π interactions in the S 1 state of zinc porphyrin dimers revealed by picosecond time-resolved resonance Raman spectroscopy. J. Phys. Chem. A 103: p. 9184-9189 1999. 218. Suga, M., J. Oku, H. Masuda, M. Takaki, M. Mukai, and T. Kitagawa, Mechanism of the anionic cyclopolymerization of bis(dimethylvinylsilyl)methane. Macromolecules 32: p. 1362-1366 1999. 219. 220. Suzuki, N., T. Higuchi, Y. Urano, K. Kikuchi, H. Uekusa, Y. Ohashi, T. Uchida, T. Kitagawa, and T. Nagano, Novel iron porphyrin-alkanethiolate complex with intramolecular NH...S hydrogen bond: Synthesis, spectroscopy, and reactivity. J. Am. Chem. Soc. 121 : p. 11571-11572 1999. 221. Tomita, T., S. Hirota, T. Ogura, J.S. Olson, and T. Kitagawa, Resonance Raman investigation of Fe-N-O structure of nitrosylheme in myoglobin and its mutants. J. Phys. Chem.B 103: p. 7044-7054 1999. 222. Wada, A., S. Ogo, Y. Watanabe, M. Mukai, T. Kitagawa, K. Jitsukawa, H. Masuda, and H. Einaga, Synthesis and characterization of novel alkylperoxo mononuclear iron(III) complexes with a tripodal pyridylamine ligand: A model for peroxo intermediates in reactions catalyzed by non-heme iron enzymes. Inorg. Chem. 38: p. 3592-3593 1999. 223. Aki, M., T. Ogura, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, A new measurement system for uv resonance Raman spectra of large proteins and its application to cytochrome c oxidase. J. Phys. Chem. 104: p. 10765-10774 2000. 224. Arii, H., S. Nagatomo, T. Kitagawa, T. Miwa, K. Jitsukawa, H. Einaga, and H. Masuda, A novel diiron complex as a functional model for hemerythrin. J. Inorg. Biochem. 82(1-4): p. 153-162 2000. 225. Hayashi, H., S. Fujinami, S. Nagatomo, S. Ogo, M. Suzuki, A. Uehara, Y. Watanabe, and T. Kitagawa, A bis(μ-oxo)dicopper(III) complex with   aromatic nitrogen donors: Structural characterization and reversible conversion between copper (I) and bis( μ -oxo)dicopper(III) species. J. Am. Chem. Soc. 122: p. 2124-2125 2000. 226. Itoh, S., M. Taki, H. Kumei, S. Takayama, S. Nagatomo, T. Kitagawa, N. Sakurada, R. Arakawa, and S. Fukuzumi, Model complexes for the active form of galactose oxidase.   Physicochemical properties of Cu(II)- and Zn(II)-phenoxyl radical complexes. Inorg. Chem. 39: p. 3708-3711 2000. 227.   Itoh, S., M. Taniguchi, N. Takada, S. Nagatomo, T. Kitagawa, and S. Fukuzumi, Effects of metal ions on the electronic, redox, and catalytic properties of cofactor TTQ of quinoprotein amine dehydrogenases. J. Am. Chem. Soc 122: p. 12087-12097 2000. 228. Nagai, M., M. Aki, R. Li, Y.Jin, H. Sakai, S. Nagatomo, and T. Kitagawa, Heme structure of hemoglobin M Iwate [α87(f8)His ->Tyr]: A UV and visible resonance Raman study. Biochemistry 39: p. 13093-13105 2000. Ogihara, T., S. Hikichi, M. Akita, T. Uchida, T. Kitagawa, and Y. Morooka, An approach O the O 2 activating mononuclear non-heme Fe enzymes: Structural characterization of Fe(II)-acetato complex and formation of alkylperoxoiron(III) species with the highly hindered hydrotris(3-tert-butyl-5-isopropyl-1-pyrazolyl)borate. Inorg. Chim. Acta 297: p. 229. 230.   Ohta, T., T. Tachiyama, K. Yoshizawa, T. Yamabe, T. Uchida, and T. Kitagawa, Synthesis, structure, and H 2 O 2 -dependent catalytic functions of disulfide-bridged dicopper(I) and related thioether-copper(I) and thioether-copper(II) complexes. Inorg. Chem. 39: p. 4358-4369 2000. Ohtsu, H., S. Itoh, S. Nagatomo, T. Kitagawa, S. Ogo, Y. Watanabe, and S. Fukuzumi, Characterization of imidazolate-bridged Cu(II)-Zn(II) heterodinuclear and Cu(II)-Cu(II) homodinuclear hydroperoxo complexes as reaction intermediate models of Cu,Zn-SOD. J. Roy. Soc. Chem. Comm.: p. 1051-1052 2000. 231. Okishio, N., R. Fukuda, M. Nagai, S. Nagatomo, and T. Kitagawa, Interactions of phosphatidylinositol 3-kinase SH3 domain with its ligand peptide studied by absorption, circular dichroism, and UV resonance Raman. Biopolymers (Biospectroscopy) 57: p. 208-217 2000. 232. Suzuki, N., T. Higuchi, Y. Urano, K. Kikuchi, T. Uchida, M. Mukai, T. Kitagawa, and T. Nagano, First synthetic NO-heme-thiolate complex relevant to nitric oxide synthase and cytochrome P450nor. J. Am. Chem. Soc. 122: p. 12059-12060 2000. 233. Taki, M., H. Kumei, S. Nagatomo, T. Kitagawa, S. Itoh, and S. Fukuzumi, Active site models for galactose oxidase containing two different phenol groups. Inorg. Chim. Acta 300-302 : p. 622-632 2000. 234. Uchida, T., H. Ishikawa, K. Ishimori, I. Morishima, H. Nakajima, S. Aono, Y. Mizutani, and T. Kitagawa, Identification of histidine 77 as the axial heme ligand of carbonmonoxy cooa by picosecond time-resolved resonance Raman spectroscopy. Biochemistry 39: p. 12747-12752 2000. 235. Uchida, T., T. Mogi, and T. Kitagawa, Resonance Raman studies of Oxo intermediates in the reaction of pulsed cytochrome bo with hydrogen peroxide. Biochemistry 39: p. 6669-6678 2000. 236. Uchida, T., M. Tsubaki, T. Kurokawa, H. Hori, J. Sakamoto, T. Kitagawa, and N. Sone, Active site structure of soxb-type cytochrome bo3 oxidase from thermophilic bacillus. J. Inorg. Biochem. 82: p. 65-72 2000. 237. Uesugi, Y., Y. Mizutani, S.G. Kruglik, A.G. Shvedko, V.A. Orlovich, and T. Kitagawa, Characterization of stimulated Raman scattering of hydrogen and mathane gases as a light source of picosecond time-resolved Raman spectroscopy. J. Raman Spectrosc. 31: p. 339-348 2000. 238. Yamamoto, K., Y. Mizutani, and T. Kitagawa, Nanosecond temperature jump and time-resolved Raman study of thermal unfolding of ribonuclease a. Biophys. J. 79: p. 485-495 2000. 239. Yamamoto, K., Y. Mizutani, and T. Kitagawa, Construction of novel 240. nanosecond temperature jump apparatuses applicable to Raman measurements and direct observation of transient temperature. Appl. Spectrosc. 54: p. 1591-1604 2000. 241. Egawa, T., D.A. Proshlyakov, H. Miki, R. Makino, T. Ogura, T. Kitagawa, and Y. Ishimura, Effects of a thiolate axial ligand on the π π* electronic states of oxoferryl porphyrins: A study of the optical and resonance Raman spectra of compounds I and II of chloroperoxidase. J. Biol. Inorg. Chem. 6: p. 46-54 2001. 242. Haruta, N., M. Aki, S. Ozaki, Y. Watanabe, and T. Kitagawa, Protein conformation change of myoglobin upon ligand binding probed by ultraviolet resonance Raman spectroscopy. Biochemistry 40 : p. 6956-6963 2001. 243. Itoh, S., H. Bandoh, M. Nakagawa, S. Nagatomo, T. Kitagawa, K.D. Karlin, and S. Fukuzumi, Formation, characterization, and reactivity of bis(μ-oxo)dinickel(iii) complexes supported by a series of bis[2-(2-pyridyl)ethyl]amine ligands. J. Am. Chem. Soc. 123: p. 11168-11178 2001. 244. Itoh, S., H. Kumei, M. Taki, S. Nagatomo, T. Kitagawa, and S. Fukuzumi, Oxygenation of phenols to catechols by a (μ-η²:H -peroxo)dicopper(ii) complex.    Mechanistic insight into the phenolase activity of tyrosinase. J. Am. Chem. Soc. 123: p. 6708-6709 2001. 245. Kim, Y., K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Presence of the heme-oxo intermediate in oxygenation of carbon monoxide by cytochrome c oxidase revealed by resonance Raman spectroscopy. J. Am. Chem. Soc. 123: p. 757-758 2001. 246. Kruglik, S.G., P. Mojzes, Y. Mizutani, T. Kitagawa, and P.-Y. Turpin, Time-resolved resonance Raman study of the exciplex formed between excited Cu-porphyrin and DNA. J. Phys. Chem. 105: p. 5018-5031 2001. 247. Mizutani, Y. and T. Kitagawa, Ultrafast structural relaxation of myoglobin following photodissociation of carbon monoxide probed by time-resolved resonance Raman spectroscopy. J. Phys. Chem. 105: p. 10992-10999 2001. 248. Ohtsu, H., S. Itoh, S. Nagatomo, T. Kitagawa, S. Ogo, Y. Watanabe, and S. Fukuzumi, Characterization of imidazolate-bridged dinuclear and mononuclear hydroperoxo complexes. Inorg. Chem. 40: p. 3200-3207 2001. 249. Okishio, N., T. Tanaka, M. Nagai, R. Fukuda, S. Nagatomo, and T. Kitagawa, Identification of tyrosine residues involved in ligand recognition by the phosphatidylinositol 3-kinase SRC homology 3 domain: Circular dichroism and UV resonance Raman studies. Biochemistry 40: p. 15797-15804 2001. 250. Tomita, T., N. Haruta, M. Aki, T. Kitagawa, and M. Ikeda-Saito, UV resonance Raman detection of a ligand vibration on ferric nitrosyl heme proteins. J. Am. Chem. Soc. 123: p. 2666-2667 2001. 251. Tomita, T., S. Ogo, T. Egawa, N. Okamoto, Y. Imai, Y. Watanabe, Y. Ishimura, and T. Kitagawa, Elucidation of the differences between the 430 and 455-nm absorbing forms of P450-isocyanide adducts by resonance Raman spectroscopy. J. Biol. Chem. 276: p. 36261-36267 2001. 252. Verma, A.L., H.H. Thanga, and T. Kitagawa, Excitation wavelength dependence of photoreduction of cytochrome c and its mechanism monitored by resonance Raman spectroscopy. Asian J. Spectrosc. (5): p. 97-111 2001. 253. Aki, M., T. Ogura, Y. Naruta, T.H. Le, T. Sato, and T. Kitagawa, UV resonance Raman characterization of model compounds of Tyr244 of bovine cytochrome c oxidase in its neutral-, deprotonated anion-, and deprotonated neutral radical-forms; effects of covalent binding between tyrosine and histidine. J. Phys. Chem. 106: p. 3436-3444 2002. 254. Aono, S., T. Kato, M. Matsuki, H. Nakajima, T. Ohta, T. Uchida, and T. Kitagawa, Resonance Raman and ligand binding studies of the oxygen sensing signal transducer protein HemAT from bacillus subtilis. J. Biol. Chem. 277: p. 13528-13538 2002. 255. Haruta, N. and T. Kitagawa, Time-resolved UV resonance Raman investigation of protein folding using a rapid mixer: Characterization of kinetic folding intermediates of apomyoglobin. Biochemistry 41: p. 6595-6604 2002. 256. Hashimoto, K., S. Nagatomo, S. Fujinami, H. Furutachi, S. Ogo, S. Suzuki, A. Uehara, Y. Maeda, Y. Watanabe, and T. Kitagawa, A new mononuclear iron(iii) complex containing a peroxocarbonate ligand. Angew Chem. Intnl. Ed. 41: p. 1202-1205 2002. 257. Hayashi, H., K. Uozumi, S. Fujinami, S. Nagatomo, K. Shiren, H. Furutachi, M. Suzuki, A. Uehara, and T. Kitagawa, Modulation of the copper-dioxygen reactivity by stereochemical effect of tetradentate tripodal ligands. Chem. Lett. (3): p. 416-417 2002. 258. Hirota, S., Y. Mizoguchi, O. Yamauchi, and T. Kitagawa, Observation of an isotope sensitive low frequency Raman band specific to metmyoglobin. J. Biol. Inorg. Chem. 7: p. 217-221 2002. 259. Kitagawa, T., Overview icpp-2: Resoance Raman spectroscopy. J. Porphyrins and Phthalocyanines 6: p. 301-302 2002. 260. Kitagawa, T., N. Haruta, and Y. Mizutani, Time-resolved resonance Raman study on ultrafast structural relaxation and vibrational cooling of photodissociated carbonmonoxy myoglobin. Biopolymers(Biospectroscopy) 67: p. 207-213 2002. 261. Mizutani, Y. and T. Kitagawa, Mode dependence of vibrational energy redistribution in nickel tetraphenylporphyrin probed b y picosecond time-resolved resonance Raman spectroscopy:    Slow IVR to phenyl peripherals. Bull. Chem. Soc. Jpn 75: p. 965-971 2002. 262. Mizutani, Y. and T. Kitagawa, Vibrational energy relaxation of metalloporphyrins in a condensed phase probed by time-resolved resonance Raman spectroscopy. Bull. Chem. Soc. Jpn 75: p. 623-639 2002. 263. Nagatomo, S., Y. Jin, M. Nagai, H. Hori, and T. Kitagawa, Changes in the abnormal α-subunit upon co-binding to the normal β-subunit of Hb M Boston: Resonance Raman, EPR, and CD study. Biophys. Chem. 98: p. 217-232 2002. 264. Nagatomo, S., M. Nagai, N. Shibayama, and T. Kitagawa, Differences in changes of the α1-β2 subunit contacts between ligand binding to the α and β subunits of hemoglobin a: UV resonance Raman analysis using Ni-Fe hybrid hemoglobin. Biochemistry 41 : p. 10010-10020 2002. 265. Ogo, S., R. Yamahara, M. Roach, T. Suenobu, M. Aki, T. Ogura, T. Kitagawa, H. Masuda, S. Fukuzumi, and Y. Watanabe, Structural and spectroscopic features of a cis(hydroxo)-Fe￼-(carboxylato) configuration as an active site model for lipoxygenases. Inorg. Chem. 41: p. 5513-5520 2002. 266. Osako, T., S. Nagatomo, Y. Tachi, T. Kitagawa, and S. Itoh, Low-temperature stopped-flow studies on the reactions of copper(ii) complexes and H 2 O 2 : The first detection of a mononuclear copper(ii)-peroxo intermediate. Angew. Chem. Intl. ed. 41: p. 4325-4328 2002. 267. Sato, A., Y. Sasakura, S. Sugiyama, I. Sagami, T. Shimizu, Y. Mizutani, and T. Kitagawa, Stationary and time-resolved resonance Raman spectra of His77 and Met95 mutants of the isolated heme domain of a direct oxygen sensor from Escherichia coli. J. Biol. Chem. 277 : p. 32650-32658 2002. Sato, K., S. Nagatomo, C. Dennison, T. Niizeki, T. Kitagawa, and T. Kohzuma, UV resonance Raman and NMR spectroscopic studies on the pH dependent metal ion release from pseudoazurin. Inorg. Chim. Acta 339: p. 383-392 2002. 268. Taki, M., S. Teramae, S. Nagatomo, Y. Tachi, T. Kitagawa, S. Itoh, and S. Fukuzumi, Fine tuning of copper(i)-dioxygen reactivity with 2-(2-pyridyl)ethylamine bidentate ligands. J. Am. Chem. Soc. 124: p. 6367-6377 2002. 269. Venkatesh, B., H. Hori, G. Miyazaki, S. Nagatomo, T. Kitagawa, and H. Morimoto, Coordination geometry of cu-porphyrin in Cu(ii)-Fe(ii) hybrid hemoglobins studied by q-band EPR and resonance Raman spectroscopies. J. Inorg. Biochem. 88: p. 310-315 2002. 270. Wada, A., S. Ogo, S. Nagatomo, T. Kitagawa, Y. Watanabe, K. Jitsukawa, and H. Masuda, Reactivity of hydroperoxide bound to a mononuclear non-heme iron site. Inorg. Chem. 41: p. 616-618 2002. 271. Arii, H., Y. Saito, S. Nagatomo, T. Kitagawa, Y. Funahashi, K. Jitsukawa, and 272. H. Masuda, C-h activation by cu(iii)2-02 intermediate with secondary amino ligand. Chem. Lett. 32: p. 156-157 2003. Fujii, T., A. Naito, S. Yamaguchi, A. Wada, Y. Funahashi, K. Jitsukawa, S. Nagatomo, T. Kitagawa, and H. Masuda, Construction of a square-planar hydroperoxo-copper(ii) complex inducing a higher catalytic reactivity. Chem. Commun.: p. 2700-2701 2003. 273. Igarashi, J., A. Sato, T. Kitagawa, I. Sagami, and T. Shimizu, CO binding study of mouse heme-regulated eif-2α kinase: Kinetics and resonance Raman spectra. Biochim. Biophys. Acta 1650: p. 99-04 2003. 274. Maiti, N.C., T. Tomita, T. Kitagawa, K. Okamoto, and T. Nishino, Resonance Raman studies on xanthine oxiase:    Observation of the Movi-ligand vibration. J. Biol. Inorg. Chem. 8: p. 327-333 2003. 275. Mizuno, M., H. Hayashi, S. Fujinami, H. Furutachi, S. Nagatomo, S. Otake, K. Uozumi, M. Suzuki, and T. Kitagawa, Ligand effect on reversible conversion between copper(i) and bis( μ -oxo)dicopper(iii) complex with a sterically hindered tetradentate tripodal ligand and monooxygenase activity of bis(μ-oxo)dicopper(iii) complex. Inorg. Chem. 42: p. 8534-8544 2003. 276. Okuno, D., T. Iwase, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Ftir detection of protonation/deprotonation of key carboxyl side chains caused by redox change of the Cu a -heme a moiety and ligand dissociation from the heme аз-Сиь center of bovine heart cytochrome c oxidase. J. Am. Chem. Soc. (125): p. 7209-7218 2003. 277. Yamaguchi, S., S. Nagatomo, T. Kitagawa, Y. Funahashi, T. Ozawa, K. Jitsukawa, and H. Masuda, Copper hydroperoxo species activated by hydrogen-bonding interaction with its distal oxygen. Inorg. Chem. 42: p. 6968-6970 2003. 278. Yamaguchi, S., A. Wada, Y. Funahashi, S. Nagatomo, T. Kitagawa, K. Jitsukawa, and H. Masuda, Thermal stability and absorption spectroscpic behavior of (μ-peroxo)dicopper complexes regulated with intramolecular hydrogen bonding interactions. Eur.J. Inorg. Chem.: p. 4378-4386 2003. 279. E.Pinakoulaki, T. Ohta, T. Soulimane, T. Kitagawa, and C. Varotsis, Simultaneous resonance Raman detection of the heme a 3 -Fe-CO and Сиь-СО species in СО-bound baз-cytochrome c oxidase from thermus thermophilus. J. Biol. Chem. 279: p. 22791-22794 2004. 280. Egawa, T., T. Hishiki, Y. Ichikawa, Y. Kanamori, H. Shimada, S. Takahashi, T. Kitagawa, and Y. Ishimura, Refolding processes of cytochrome P450cam from ferric and ferrous acid forms to the native conformation. J. Biol. Chem. 279: p. 32008-32017 2004. 281. Egawa, T., N. Suzuki, T. Dokoh, T. Higuchi, H. Shimada, T. Kitagawa, and Y. Ishimura, Vibronic coupling between Soret and higher energy excited states in 282. iron(ii) porphyrins: Raman excitation profiles of a g modes in the Soret region. J. Phys. Chem. A 108: p. 568-577 2004. 283. Hiramatsu, H., Y. Goto, H. Naiki, and T. Kitagawa, Core structure of amyloid fibril proposed from IR-microscope linear dichroism. J. Am. Chem. Soc. 126: p. 3008-3009 2004. 284. Igarashi, J., A. Sato, T. Kitagawa, T. Yoshimura, S. Yamauchi, I. Sagami, and T. Shimizu, Activation of heme-regulated eukaryotic initiation factor 2α kinase (HRI) activation by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: Optical absorption, electron spin resonance and resonance Raman spectral studies. J. Biol. Chem. 279: p. 15752-15762 2004. 285. Jin, Y., M. Nagai, Y. Nagai, S. Nagatomo, and T. Kitagawa, Heme structures of five variants of hemoglobin m probed by resonance Raman spectroscopy. Biochemistry 43: p. 8517-8527 2004. 286. Komiyama, K., H. Furutachi, S. nagatomo, A. Hashimoto, H. Hayashi, S. Fujinami, M. Suzuki, and T. Kitagawa, Dioxygen reactivity of copper(i) complexes with tetradentate tripodal ligands having apliphatic nitrogen donors: Synthesis, structures, and properties of peroxo and superoxo complexes. Bull. Chem. Soc. Jpn 77: p. 59-72 2004. 287. Konishi, K., K. Ishida, K. Oinuma, T. Ohta, Y. Hashimoto, H. Higashibata, T. Kitagawa, and M. Kobayashi, Identification of crucial histidines involved in carbon-nitrogen triple bond synthesis by aldoxime dehydratase. J. Biol. Chem. 279: p. 47619-47625 2004. 288. Matsuda, Y., T. Uchida, H. Hori, T. Kitagawa, and H. Arata, Structural characterization of a binuclear center of a Cu-containing no reductase homologue from roseobacter denitrificans: EPR and resonance Raman studies. Biochim. Biophys. Acta 1656: p. 37-45 2004. 289. Ogura, T. and T. Kitagawa, Resonance Raman characterization of the P intermediate in the reaction of bovine cytochrome c oxidase. Biochim. Biophys. Acta 1655: p. 290-297 2004. 290. Ohta, T., E. Pinakoulaki, T. Soulmane, T. Kitagawa, and C. Varotsis, Detection of a photosatable five-coordinate heme a3-Fe-CO species and functional implications of His384/α10 in CO-bound ba3-cytochrome c oxidase from thermus thermophilus. J. Phys. Chem. B 108: p. 5389-5491 2004. 291. Ohta, T., H. Yoshimura, S. Yoshioka, S. Aono, and T. Kitagawa, Oxygen sensing mechanism of hemat from b. Subtilis: A resonance Raman spectroscopic study. J. Am. Chem. Soc. 126: p. 15000-15001 2004. 292. Oinuma, K., T. Ohta, K. Konishi, Y. Hashimoto, H. Higashibata, T. Kitagawa, and M. Kobayashi, Heme environment in aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis. FEBS Lett. 568: p. 44-48 2004. Pal, B., Z. Li, T. Ohta, S. Takenaka, S. Tsuyama, and T. Kitagawa, Resonance Raman study on synergistic activation of soluble guanylate cyclase by imidazole, YC-1 and GTP. J. Inorg. Biochem. 98, p.824-832 2004. 293. Sato, E., I. Sagami, T. Uchida, A. Sato, T. Kitagawa, J. Igarashi, J.S. Olson, and T. Shimizu. Soul in mouse eyes is a novel hexameric heme-binding protein with characteristic optical absorption, resonance Raman spectral and heme binding properties. Biochemstry, 43, p.14189-14197 2004. 294. 295.   Taki, M., H. Hattori, T. Osako, S. Nagatomo, M. Shiro, T. Kitagawa, and S. Itoh, Model complexes of the active site of galactose oxidase. Effects of the metal ion binding sites. Inorg. Chim. Acta 357: p. 3369-3381 2004. Teramae, S., T. Osako, S. Nagatomo, T. Kitagawa, S. Fukuzumi, and S. Itoh, Dinuclear copper-dioxygen intermediates supported by polyamine ligands. J. Inorg. Biochem. 98: p. 746-757 2004. 296. Uchida, T., T. Mogi, H. Nakamura, and T. Kitagawa, Role of tyr-288 at the dioxygen reduction site of cytochrome bo studied by stable isotope labeling and resonance Raman spectroscopy. J. Biol. Chem. 279: p. 53613-53620 2004. 297. Uchida, T., J.M. Stevens, O. Daltrop, E.M. Harvat, L. Hong, S.J. Ferguson, and T. Kitagawa, The interaction of covalently bound heme with the cytochrome c maturation protein CcmE. J. Biol. Chem. 279: p. 51981-51988 2004. 298. Wada, A., Y. Honda, S. Yamaguchi, S. Nagatomo, T. Kitagawa, K. Jitsukawa, and H. Masuda, Steric and hydrogen-bonding effects on the stability of copper complexes with small molecules. Inorg. Chem. 43: p. 5725-5735 2004. 299. Yamaguchi, S., A. Wada, S. Nagatomo, T. Kitagawa, K. Jitsukawa, and H. Masuda, Thermal stability of mononuclear hydroperoxocopper(ii) species. Effects of hydrogen bonding and hydrophobic field. Chem. Lett. 33: p. 1556-1557 2004. 300. Furutachi, H., K. Hashimoto, S. Nagatomo, T. Endo, S. Fujinami, Y. Watanabe, T. Kitagawa, and M. Suzuki, Reversible O-O bond cleavage and formation of a peroxo moiety of peroxocabonate ligand performed by an iron(iii) complex. J. Am. Chem. Soc. 127: p. 4550-4551 2005. 301. Hiramatsu, H., Y. Goto, H. Naiki, and T. Kitagawa, Structural model of the amyloid fibril formed by β 2 -microglobulin #21-31 fragment based on vibrational spectroscopy. J. Am. Chem. Soc. 127 : p. 7988-7989 2005. 302. Inagaki, S., C. Masuda, T. Akaishi, H. Nakajima, S. Yoshioka, T. Ohta, B. Pal, T. Kitagawa, and S. Aono, Spectroscopic and redox properties of a CooA homologue from carboxydothermus hydrogenoformans. J. Biol. Chkem. 280 : p. 3269-3274 2005. 303. Itoh, K., H. Hayashi, H. Furutachi, T. Matsumoto, S. Nagatomo, T. Tosha, S. 304. Terada, S. Fujinami, M. Suzuki, and T. Kitagawa, Synthesis and reactivity of a (μ-1.1-hydroperoxo)(μ-hydroxo)dicopper(ii) complex: Ligand hydroxylation by a bridging hydroperoxo ligand. J. Am. Chem. Soc. 127 : p. 5212-5223 2005. 305. Koudo, R., H. Kurokawa, E. Sato, J. Igarashi, T. Uchida, I. Sagami, T. Kitagawa, and T. Shimizu, Spectroscopic characterization of the isolated heme-bound PAS-B domain of neuronal PAS domain protein 2 (NPAS2) associated with circadian rhythms. FEBS J. 272: p. 4153-4162 2005. 306. Kurahashi, T., Y. Kobayashi, S. Nagatomo, T. Tosha, T. Kitagawa, and H. Fujii, Oxidizing intermediates from the sterically hindered iron salen complexes related to the oxygen activation by nonheme iron enzymes. Inorg. Chem. 44: p. 8156-8166 2005. 307. Li, Z.Q., B. Pal, S. Takenaka, S. Tsuyama, and T. Kitagawa, Resonance Raman evidence for the presence of two heme pocket conformations with varied activities in CO-bound bovine soluble guanylate cyclase and their conversion. Biochemistry 44: p. 939-946 2005. 308. Matsuura, K., Y. Shiro, T. Tosha, H. Hori, K. Ishimori, T. Kitagawa, I. Morishima, N. Kagawa, and M.R. Waterman, Structural diversities of active site in clinical azole-bound forms between sterol 14α-demethylases (CYP51s) from human and mycobacterium tuberculosis. J. Biol. Chem. 280 : p. 9088-9096 2005. 309. Mo, Y.-J., D.-L. Jiang, M. Uyemura, T. Aida, and T. Kitagawa, Energy funneling of IR photons captured by dendritic antennae and acceptor mode specificity: Anti-stokes resonance raman studies on iron(iii)-porphyrin complexes with a poly(aryl ether) dendrimer framework. J. Am. Chem. Soc. 127: p. 10029-10027 2005. 310. Nagano, Y., J.-G. Liu, Y. Naruta, and T. Kitagawa, Uv resonance raman study of model complexes of the cu ь site of cytochrome c oxidase. J. Mol. Struct. 735-736 : p. 279-291 2005. 311. Nagatomo, S., M. Nagai, Y. Mizutani, T. Yonetani, and T. Kitagawa, Quaternary structures of intermediately ligated hemoglobin and influences from strong allosteric effectors; resonance raman investigation. Biophys. J. 89: p. 1203-1213 2005. 312. Ohta, T., B. Pal, and T. Kitagawa, Excited state property of hardly photodissociable heme-CO adduct studied by time-dependent density functional theory. J. Phys. Chem. B 109: p. 21110-21117 2005. 313. Oinuma, K., H. Kumita, T. Ohta, K. Konishi, Y. Hashimoto, H. Higashibata, T. Kitagawa, Y. Shiro, and M. Kobayashi, Stopped-flow spectrophotometric and resonance Raman analyses of aldoxime dehyratase involved in carbon-nitrogen triple bond synthesis. FEBS Lett. 579: p. 1394-1398 2005. 314. Osako, T., S. Terada, T. Tosha, S. Nagatomo, H. Furutachi, S. Fujinami, T. Kitagawa, M. Suzuki, and S. Itoh, Structure and dioxygen-reactivity of copper(i) complexes supported by bis(6-methylpyridin-2-yl-methyl)amine tridentate ligands. Dalton Trans.    2005. 315. Pal, B. and T. Kitagawa, Interactions of soluble guanylate cyclase with diatomics as probed by resonance Raman spectroscopy. J. Inorg. Biochem. 99: p. 267-279 2005. 316. Pinakoulaki, E., T. Ohta, T. Soulimane, T. Kitagawa, and C. Varotsis, Detection of the His-heme Fe²+-no species   in the reduction of NO to N 2 O by ba3-oxidase from thermus thermophilus. J. Am. Chem. Soc. 127: p. 15161-15167 2005. 317. Sastri, C.V., M.J. Park, T. Ohta, T.A. Jackson, A. Stubna, M.S. Seo, J. Lee, J. Kim, T. Kitagawa, E. Munck, J. L. Que, and W. Nam, Axial ligand substituted nonheme Felv=O complexes: Observation of new near UV LMCT bands and Fe=O Raman vibrations. J. Am. Chem. Soc. 127: p. 12494-12495 2005. 318. Sawai, H., M. Makino, Y. Mizutani, T. Ohta, H. Sugimoto, T. Uno, N. Kawada, K. Yoshizato, T. Kitagawa, and Y. Shiro, Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin. Biochemistry 44: p. 13257-13265 2005. 319. Zhang, X., H. Furutachi, S. Fujinami, S. Nagatomo, Y. Maeda, Y. Watanabe, T. Kitagawa, and M. Suzuki, Structural and spectroscopic characterization of (μ-hydroxo or μ-oxo)(μ-peroxo)diiron(iii) complexes; model for peroxo intermediates of non-heme diiron proteins. J. Am. Chem. Soc. 127: p. 826-827 2005. 320. Uchida, T., E. Sato, A. Sato, I. Sagami, T. Shimizu, and T. Kitagawa, CO-dependent activity-controlling mechanism of heme-containing CO-sensor protein, neuronal PAS domain protein 2. J. Biol. Chem. 280: p. 21358-21368 2005. 321. Yamaguchi, S., A. Kumagai, S. Nagatomo, T. Kitagawa, Y. Funahashi, T. Ozawa, K. Jitsukawa, and H. Masuda, Synthesis, characterization, and thermal stability of new mononuclear hydrogenperoxocopper(ii) complexes with M3O-type tripodal ligands bearing hydrogen-bonding interaction sites. Bull. Chem. Soc. Jpn 78: p. 116-124 2005. 322. Yoshioka, S., K. Kobayashi, H. Yoshimura, T. Uchida, T. Kitagawa, and S. Aono, Biophysical properties of a c-type heme in chemotaxis signal transducer protein DcrA. Biochemistry 44: p. 15406-15413 2005.. 323.   Tosha, T., N. Kagawa, T. Ohta, S. Yoshioka, M.R. Waterman, and T. Kitagawa, Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome p450 aromatase during the three consecutive oxygen activation steps. Biochemistry 45: p. 5631-5640 2006. Tosha, T., T. Uchida, A.R. Brash, and T. Kitagawa, On the relationship of coral 324. allene oxide synthase to catalase: A single active site mutation that induces catalase activity in coral allene oxide synthase. J. Biol. Chem. 281 , p.12610-12617 2006. 325. Yoshimura, H., S. Yoshioka, K. Kobayashi, T. Ohta, T. Uchida, M. Kubo, T. Kitagawa, and S. Aono, Specific hydrogen-bonding networks responsible for selective O 2 sensing of the oxygen sensor protein HemAT from bacillus subtilis. Biochemistry 45: p. 8301-8307 2006 326. Fujii, H., T. Kurahashi, T. Tosha, T. Yoshimura, and T. Kitagawa, 170 NMR study of oxo metalloporphyrin complexes: Correlation with electronic structure of M=O moiety. J. Inorg. Biochem. 100: p. 533-541 2006. 327.   Fujii, T., S. Yamaguchi, Y. Funahashi, T. Ozawa, T. Tosha, T. Kitagawa, and H. Masuda, Mononuclear copper(ii)-hydroperoxo complex derived from reaction of copper(i) complex with dioxygen as a model of DβM and PHM. Chem. Commun.: p. 4428-4430 2006. 328. Gao, Y., S.F. El-Mashtoly, B. Pal, T. Hayashi, K. Harada, and T. Kitagawa, Pathway of information transmission from heme to protein upon ligand binding/dissociation in myoglobin revealed by UV resonance Raman spectroscopy. J. Biol. Chem. 281 : p. 24637-24646 2006. 329. Gao, Y., M. Koyama, S.F. El-Mashtoly, T. Hayashi, K. Harada, Y. Mizutani, and T. Kitagawa, Time-resolved Raman evidence for energy funneling through propionate side chains in heme cooling upon photolysis of carbonmonoxy myoglobin. Chem. Phys. Lett. 429: p. 239-243 2006. 330. K.Konishi, T. Ohta, K. Oinuma, Y. Hashimoto, T. Kitagawa, and M. Kobayashi, Discovery of a reaction intermediate of aliphatic aldoxime dehydratase involving heme as an active center. Proc. Natl. Acad. Sci. U.S.A. 103: p. 564-568 2006. Kobayashi, K., B. Pal, S. Yoshioka, Y. Kato, Y. Asano, T. Kitagawa, and S. Aono, Spectroscopic and substrate binding properties of heme-containing aldoxime dehydratases, Oxd B and Oxd RE. J. Inorg. Biochem. 100: p. 1069-1074 2006. 331. Kubo, M., S. Inagaki, S. Yoshioka, T. Uchida, Y. Mizutani, S. Aono, and T. Kitagawa, Evidence for displacement of the c-helix by co ligation and DNA binding to cooa revealed by UV resonance Raman spectroscopy. J. Biol. Chem. 281: p. 11271-11278 2006. 332. Li, J., T. Uchida, T. Ohta, T. Todo, and T. Kitagawa, Characteristic structure and environment in FAD cofactor of (6-4) photolyase along function revealed by resonance Raman spectroscopy. J. Phys. Chem. B 110: p. 16724-16732 2006. 333. Li, J., T. Uchida, T. Todo, and T. Kitagawa, Similarities and differences between cyclobutane pyrimidine dimer (CPD) photolyase and (6-4) photolyase 334. as revealed by resonance Raman spectroscopy: Electron transfer from FAD cofactor to UV-damaged DNA. J. Biol. Chem. 281 : p. 25551-25559 2006. Lu, M., H. Hiramatsu, Y. Goto, and T. Kitagawa, Structure of interacting segments in the growing amyloid fibril of β 2 -microglobulin probed with IR spectroscopy. J. Mol. Biol. 362: p. 355-364 2006. 335. Matsumoto, T., H. Furutachi, M. Kobino, M. Tomii, S. Nagatomo, T. Tosha, T. Osako, S. Fujinami, S. Itoh, T. Kitagawa, and M. Suzuki, Intramolecular arene hydroxylation versus intermolecular olefin epoxidation by (μ-η²:HP-peroxo)dicopper(ii) complex supported by dinucleating ligand.  J. Am. Chem Soc. 128: p. 3874-3875 2006. 336. Mukaiyama, Y., T. Uchida, E. Sato, A. Sasaki, Y. Sato, J. Igarashi, H. Kurokawa, I. Sagami, T. Kitagawa, and T. Shimizu, Spectroscopic and DNA-binding characterization of the isolated heme-bound basic Helix-Loop-Helix-PAS-A domain of neuronal pas protein 2 (NPAS2), a transcription activator protein associated with circadian rhythms. FEBS J. 273: p. 2528-2539 2006. 337. Nagano, Y., J.-G. Liu, Y. Naruta, T. Ikoma, S. Tero-Kubota, and T. Kitagawa, Characterization of the phenoxyl radical in model complexes for the Сиь site of cytochrome c oxidase: Steady-state and transient absorption measurements, UV resonance Raman spectroscopy, EPR spectroscopy, and DFT calculations for M-BIAIP. J. Am. Chem. Soc. 128: p. 14560-14570 2006. 338. Neya, S., K. Imai, Y. Hiramatsu, T. Kitagawa, T. Hoshino, M. Hata, and N. Funasaki, Significance of the molecular shape of iron corrphycene ina protein pocket. Inorg. Chem. 45: p. 4238-4242 2006. 339. Stevens, J.M., T. Uchida, O. Daltrop, T. Kitagawa, and S.J. Ferguson, Dynamic ligation properties of the Escherichia coli heme chaperone CcmE to non-covalently bound heme. J. Biol. Chem. 281: p. 6144-6151 2006. 340. Neya, S., A. Takahashi, H. Ode, T. Hoshino, M. Hata, A. Ikezaki, Y. Ohgo, M. Takahashi, H. Hiramatsu, T. Kitagawa, Y. Furutani, H. Kandori, N. Funasaki, and M. Nakamura, Magnetic and infrared properties of the azide complex of (2,7,12,17-tetrapropylporphycenato)iron(iii): A novel admixing mechanism of the S = 5/2 and S = 3/2 states. Eur. J. Inorg. Chem.: p. 3188-3194 2007. 341. Varotsis, C., T. Ohta, T. Kitagawa, T. Soulimane, and E. Pinakoulaki, The structure of the hyponitrite species in a heme Fe-Cu binuclear center. Angew. Chem. Intl. ed. 46: p. 1-6 2007. 342. Sato, A., Y. Gao, T. Kitagawa, and Y. Mizutani, Primary protein response after ligand photodissociation in carbonmonoxy myoglobin. Proc. Natl. Acad. Sci. U.S.A. 104: p. 9627-9632 2007.. 343. El-Mashtoly, S.F., H. Takahashi, T. Shimizu, and T. Kitagawa, Ultraviolet resonance Raman evidence for utilization of the heme 6-propionate 344. hydrogen-bond network in signal transmission from heme to protein in Ec Dos protein. J. Am. Chem. Soc. 129: p. 3556-3563 2007. Hersleth, H.-P., T. Uchida, A.K. Rohr, T. Teschner, V. Schunemann, T. Kitagawa, A. Trautwein, C.H. Gorbitz, and K.K. Andersson, Crystallographic and spectroscopic studies of peroxide-derived myoglobin compound ii and occurrence of protonated Fe(iv)-O. J. Biol. Chem. 282: p. 23372-23386 2007. 345. Hirai, K., M. Martinkova, J. Igarashi, I. Saiful, S. Yamauchi, S. El-Mashtoly, T. Kitagawa, and T. Shimizu, Identification of Cys385 in the isolated kinase insertion domain of heme-regulated Eif2α kinase (Hri) as the heme axial ligand by site-directed mutagenesis and spectral characterization. J. Inorg. Biochem. 101 : p. 1172-1179 2007. 346. Neya, S., A. Takahashi, H. Ode, T. Hoshino, A. Ikezaki, Y. Ohgo, M. Takahashi, Y. Furutani, V.A. Lorenz-Fonfria, H. Kandori, H. Hiramatsu, T. Kitagawa, J. Teraoka, N. Funasaki, and M. Nakamura, Electronic properties in a five-coordinate azido complex of nonplanar iron(iii) porphyrin: Revisiting to quantum mechanical spin admising. Bull. Chem. Soc. Jpn 81: p. 136-141 2008. 347. Tosha, T., N. Kagawa, M. Arase, M.R. Waterman, and T. Kitagawa, Interaction between substrate and oxygen ligand responsible for effective O-O bond cleavage in bovine cytochrome p450 steroid 21-hydroxylase proved by Raman spectroscopy. J. Biol. Chem. 283: p. 3708-3717 2008. 348. Kubo, M., T. Uchida, S. Nakashima, and T. Kitagawa, Construction of a subnanosecond time-resolved high-resolution ultraviolet resonance Raman measurement system and its application to reveal the dynamic structures of proteins. Appl. Spectrosc. 62: p. 30-37 2008.. 349. Hersleth, H.-P., A. Varnier, E. Harbitz, A.K. Rohr, P.P. Schmidt, M. Sorlie, F.H. Cederkvist, S. Marchal, A.C. F.Gorren, B. Mayer, T. Uchida, V. Schunemann, T. Kitagawa, A.X. Trautwein, T. Shimizu, R. Lange, C.H. Gorbitz, and K.K. Andersson, Reactive complexes in myoglobin and nitric oxide synthase. Inorg. Chim. Acta 361: p. 831-843 2008.. 350. El-Mashtoly, S.F., Y. Gu, H. Yoshimura, S. Yoshioka, S. Aono, and T. Kitagawa, Protein conformation changes of HemAT-bs upon ligand binding probed by ultraviolet resonance Raman spectroscopy. J. Biol. Chem. 283: p. 6942-6949 2008. 351. El-Mashtoly, S.F. and T. Kitagawa, Structural chemistry involved in information detection and transmission by gas sonsor heme proteins: Resonance Raman Investigation, Pure and Appl. Chem. 80, p.2667-2678, 2008. 352. El-Mashtoly, S.F., S. Nakashima, A. Tanaka, T. Shimizu, and T. Kitagawa, Roles of Arg97 and Tyr113 in regulation of distal ligand binding to heme in Ec Dos protein: Resonance Raman and mutation study. J. Biol. Chem. 283 ; p.19000-19010, 2008. 353. 354. El-Mashtoly, S.F., H. Takahashi, T. Shimizu, and T. Kitagawa, Resonance Raman investigation of redox-induced structural changes of protein and heme in the sendor domain of Ec Dos protein. J. Raman Spectrosc. 39. P.1614-1626, 2008. 355. T. Kurahashi, A. Kikuchi, T. Tosha, Y. Shiro, T. Kitagawa, and H. Fujii, Transient intermediates from Mn(salen) with sterically hindered mesityl groups: Interconversion between Mn l v-phenolate and Mn l l -phenoxyl radicals as an origin for unique reactivity. Inorg. Chem. 47: p.1674-1686, 2008. 356. Y. Aki , M. Nagai, Y. Nagai, K. Imai, M. Aki, A. Sato, M. Kubo, S. Nagatomo, T. Kitagawa, Differences in coordination states of substituted tyrosine residues and quaternary structures among Hemoglobins M probed by resonance Raman spectroscopy J. Biol. Inorg. Chem. 15: p.147-158 2010. 357. Pal, B., K. Tanaka, S. Takenaka, and T. Kitagawa, Resonance Raman spectroscopic investigation of structural changes of CO-heme in soluble guanylate cyclase generated by effectors and substrate. J. Raman Spectrosc. 41, 1178-1184,41, 2010. 358. H. Hiramatsu, M. Lu, K. Matsuo, K. Gekko, Y. Goto and T. Kitagawa Differences in the Molecular Structure of □β²-Microglobulin between Two Morphologically Different Amyloid Fibrils, Biochemistry 49: p.742-751 2010. 359. H. Hiramatsu, M. Lu, Y. Goto, and T. Kitagawa, The β-sheet Structure pH Dependence of the Core Fragments of β 2 -microglobulin Amyloid Fibrils. Bull. Chem. Soc. Jpn. 83, p.495-504 2010. Pal, B. and T. Kitagawa, Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase; A new perspective to the mechanism of activation. Biochem. Biophys. Res. Commun. 397, p.375-379, 2010. 360. Pal, B. and T. Kitagawa, Differences between two active forms of CO-bound soluble guanylate cyclase in the presence of activators and substrate and their populations revealed by resonance Raman spectroscopy. Ind. J. Chem. 50A, p.395-400. 2011. 361. 362. Nagatomo, S., M. Nagai, and T. Kitagawa, A new way for understanding quaternary structure change of hemoglobin upon ligand binding on the basis of UV-resonance Raman evaluation of inter-subunit interactions. J. Am. Chem. Soc.133, 10101-10110, 2011. 363. El-Mashtoly, S., M. Kubo, S. Nakashima, T. Shimizu, and T. Kitagawa, Structural Dynamics of EcDOS Heme Domain Revealed by Time-Resolved Ultraviolet Resonance Raman Spectroscopy. J. Phys. Chem. Lett. 2, 2212-2217, 2011. 364. Li, J, and T. Kitagawa, Appllications of Vibrational Spectroscopyn in the Study of Flavin-based Photoactive Proteins. Spectroscopy, 25, 261-269, 2011. 365. Uchida, T., I. Sagami, T. Shimizu, K. Ishimori, and T. Kitagawa, Effects of the bHLH domain on axial coordination of heme in the PAS-A domain of neuronal PAS domain protein 2 (NPAS2): Conversion from His119/Cys170 coordination to His119/His171 coordination. J. Inorg. Biochem.     108, 188-195, 2012. 366. El-Mashtoly, S. F., M. Kubo, Y. Gu. H. Sawai, S. Nakashima, T. Ogura, S. Aono, and T. Kitagawa, Site-specific protein dynamics in communication pathway from sensor to signaling domain of oxygen sensor protein, HemAT-Bs:   Time-resolved ultraviolet resonance Raman study. J. Biol. Chem. 287, 19973-19984, 2012. 367. Nagai, M., S. Nagatomo, Y. Nagai, K. Ohkubo, K. Imai, and T. Kitagawa, Near-UV circular dichroism and UV resonance Raman spectra of individual tryptophan residues in human hemoglobin and their changes upon the quaternary structure transition. Biochemistry 51, 5932-5941, 2012. 368. Tsugawa, T., H. Furutachi, M. Marunaka, T. Endo, K. Hashimoto, S. Fujinami, S. Akine, Y. Sakata, S. Nagatomo, T. Tosha, T. Nomura, T. Kitagawa, T.Ogura, and M. Suzuki, Oxidation Reactivity of a Structurally and Spectroscopically Well-defined Mononuclear Peroxocarbonato-Iron(III) Complex. Chem. Lett. 44, 330-332, 2015. 369.    Sekino, M., H. Furutachi, K. Tasaki, T. Ishikawa, S. Mori, S. Fujinami, S. Akine, Y. Sakata, T. Nomura, T. Ogura, T. Kitagawa, and M. Suzuki, New Mechanistic Insight into Intramolecular Arene Hydoroxilation Initiated by (μ-1,2-peroxo)Diiron(III) Complexes with Dinucleating Ligands, Dalton Tras. 45, 469-473, 2016 370. Xu, H., Y. Zhang, L. Chen, Y. Li, C. Li, L. Liu, T. Ogura, T. Kitagawa, and Z. Li, Entry of Water into the Distal Heme Pocket of Soluble Guanylate Cyclase β1 H-NOX Domain Alters the Ligated CO Strictre: A Resonance Raman and in silico Simulation Study.   RSC Adv. 6, 43707-43714 2016. 371. Nagatomo, S., M. Okumura, K. Saito, T. Ogura, T. Kitagawa, and M. Nagai, Interrelatioship among Fe-His Bond Strengths, Oxygen Affinities, and Intersubunit Hydrogen Bonding Changes upon Ligand Binding in the β Subunit of Human Hemoglobin: The Alkaline Bohr Effect. Biochemisry, 56, 1261-1273. 2017. 372. Nagatomo, S., K. Saito, K. Yamamoto, T. Ogura, T. Kitagawa, and M. Nagai, Heterogeneity between Two α Subunits of α₂β₂ Human Hemoglobin and O₂ Binding Properties: Raman, 1H Nuclear Magnetic Resonance, and Terahertz Spectra, Biochemistry, 56, 6125-6136, 2017. 373. Nagai, M., N. Mizusawa, T. Kitagawa and S. Nagatomo, A Role of Heme Side-chains of Human Hemoglobin in Its Function Revealed by Circular Dichroism and Resonance RamanSpectroscopy, Biophys. Rev.10 , 271-284, 2017. 374. Mieda-Higa, K., A. Al Mamun, T. Ogura, T. Kitagawa, and P. W. Kozlowski, Resonance Raman Investigation of Dithionite-reduced Cobalamin, J. Raman Spectrosc. 1-12, 2020. 375. Nagatomo, S., T. Kitagawa, and M. Nagai, Roles of Fe-Histidine Bonds in Stability of Hemoglobin: Recognition of Protein Flexibility by Q Sepharose, Biophys. J. 120, 1-12, 2021. 376. Nagatomo, S., M. Nagai, and T. Kitagawa, Structural Origin of Cooperativity in Human Hemoglobin: A View from Different Roles of α and β Subunits in the α2β2 Tetramer, Biophys. Rev. 14, 483-498, 2022.
Review Articles and Procedings
1. Kitagawa, T. and T. Miyazawa, Frequency distribution of crystal vibrations and specific heat of polyethylene. Rept. Progr. Polymer Phys. Jpn. 8: p. 53-56 1965. 2. Kitagawa, T. and T. Miyazawa, Interchain potential, frequency distribution and specific heat of polyoxymethylene crystal. Rept. Progr. Polymer Phys. Jpn. 9: p. 175-178 1966. 3. Kitagawa, T. and T. Miyazawa, Inelastic scattering cross section of neutron by crystal vibrations of polyethylene. Rept. Progr. Polymer Phys. Jpn. 10: p. 185-186 1967. 4. Kitagawa, T. and T. Miyazawa, Interchain potential, frequency spectrum, specific heat, and root mean squared displacement in polyethylene crystal. Rept. Progr. Polymer Phys. Jpn. 11: p. 219-221 1968. 5. Kitagawa, T. and T. Miyazawa, Thermal expansion of polyethylene crystal in the quasi-harmonic approximation. Rept. Progr. Polymer Phys. Jpn. 11: p. 209-212 1968. 6. Kitagawa, T., Neutron scattering and vibrational spectra of molecular crystals. Appl. Spectrosc. Rev. 6: p. 79-134 1972. 7. Kitagawa, T. and T. Miyazawa, Neutron scattering and normal vibrations of polymers. Adv. Polymer Sci. 9: p. 336-414 1972. 8. Kitagawa, T. and Y. Orii, Two kinds of the oxidized state of cytochrome oxidase studied by resonance raman spectra, in Cytochrome oxidase, B. Chance, et al., Editors. 1978, Elsevier: New York. p. 129-138. 9. Kitagawa, T., Y. Ozaki, and Y. Kyogoku, Resonance raman studies on the ligand-iron interactions in hemoproteins and metalloporphyrins. Adv. Biophys. 11: p. 153-198 1978. 10. Kitagawa, T., Resonance raman spectra of flavoenzyme-inhibitor charge-transfer complexes, in Proc. Viith interl. Conf. Raman spectrosc., W.F. Murphy, Editor. 1980, North-Holland: New York. p. 524-527. 11. Kitagawa, T. Resonance raman spectra of flavoenzyme-inhibitor charge-transfer complexes. in VIIth Internaltional Conference on Raman Spectroscopy. 1980. Ottawa. 12. Kitagawa, T. and K. Nagai. Resonance raman evidence for a stretched fe-n ε (his f8) bond in the t-structure deoxyhemoglobin. in International Symposium on The Interactions Between Iron and Proteins in Oxygen and Electron Transport. 1980. Virginia. 13. Kitagawa, T., Y. Nishina, K. Shiga, Y. Matsumura, and T. Yamano, Resonance raman spectra and band assignments of riboflavin derivatives, in Flavins and flavoproteins, K. Yagi and T. Yamano, Editors. 1980, Japan Sci. Soc. Press/Elsevier: Tokyo. p. 395-404. 14. Kitagawa, T. and J. Teraoka. Coordination characteristics of proximal histidine of plant peroxidases and their relevance to the heme-linked ionization. in NATO Advanced Study Institute for "Coordination Chemistry Environments in Iron-Containing Proteins and Enzymes". 1980. Alberta. 15. Kitagawa, T., The iron-histidine stretching raman line as a probe of the proximal histidine of hemoproteins, in Oxygenases and oxygen metabolism, M. Nozaki, et al., Editors. 1982, Academic Press: Tokyo. p. 451-456. 16. Kitagawa, T., The iron-histidine stretching raman line as a probe of the strain in the Iow affinity hemoglobin, in Hemoglobin, A.G. Schnek and C. Paul, Editors. 1982, Brussel University Press: Brussel. p. 235-251. 17. Kitagawa, T. and K. Nagai, Resonance raman evidence for a stretched fe-n ε (his f8) bond in the t-structure deoxy hemoglobin, in Interactions between iron and proteins in electron and oxygen transport. 1982, Elsevier: New York. p. 217-222. 18. Kitagawa, T. and K. Nagai, Resonance raman evidence for a stretched fe-n s (his f8) bond in the t-structure deoxyhemoglobin, in Hemoglobin and oxygen binding, C. Ho, Editor. 1982, Elsevier: New York. p. 217-222. 19. Kitagawa, T. and J. Teraoka, Coordination characteristics of proximal histidine of plant peroxidases and their relevance to the heme-linked ionization, in The biological chemistry of iron, H.B. Dunford, et al., Editors. 1982, D. Reidel: Dordrecht. p. 375-389. Sakamoto, H., T. Kitagawa, T. Sugiyama, Y. Miyake, and T. Yamano, 20. Resonance raman study on the reaction intermediates of adrenodoxin reductase and nadph, in Flavins and flavoproteins, V. Massey and J. C. H. Williams, Editors. 1982. Elsevier: New York. p. 684-688. 21. Yamano, T., T. Sugiyama, Y. Nonaka, Y. Ichikawa, T. Kitagawa, H. Sakamoto, and Y. Miyake, Interaction of adrenodoxin reductase with the electron donor and acceptor, in Flavins and flavoproteins, V. Massey and J. C. H. Williams, Editors. 1982, Elsevier: New York. p. 647-654. 22. Kitagawa, T. The iron-histidine stretchng raman line as a probe of the strain in the Iow affinity hemoglobin. in Brussels Hemoglobin Symposium. 1983. Brussel. 23. Kitagawa, T., Resonance raman study on enzyme-substrate interactions of heme- and flavo-enzymes, in Biomolecules - electronic aspects, C. Nagata, et al., Editors. 1985, Japan Sci. Soc. Press/Elsevier: Tokyo. p. 205-223. 24. Kitagawa, T. Resonance raman study on electron transfer of cytochrome oxidase. in Japan-US Seminar on Time-Resolved Vibrational Spectroscopy. 1985. Hawaii. 25. Kitagawa, T., S. Hashimoto, and T. Oqura, Resonance raman spectra of reaction intermediates of heme enzymes, in Time resolved vibrational spectroscopy, A. Leabreau and M. Stockburger, Editors. 1985, Springer-Verlag: Heidelberg. p. 211-215. 26. Kitagawa, T., S. Hashimoto, and T. Ogura. Resonance raman spectra of reaction intermediates of heme enzymes. in Ilth International Conference on Time-Resolved Vibrational Spectroscopy. 1985. Bayreuth-Bischofsgrun. 27. Ozaki, Y., T. Kitagawa, H. Ogoshi, T. Ochiai, and K. Iriyama, Comparative study of metallochlorins and metalloporphyrins by resonance raman spectroscopy. Rev. Port. Quim. 27: p. 340-341 1985. 28. Kitagawa, T., Resonance raman spectra of reaction intermediates of heme enzymes, in Advances in spectroscopy, R.J.H. Clark and R.E. Hester, Editors. 1986, Wiley. p. 443-481. 29. Kitagawa, T. Resonance raman spectra of catalytic intermediates of heme enzymes. in Xth International Conference on Raman Spectroscopy. 1986. Uegene. 30. Kitagawa, T., Resonance raman spectra of reaction intermediates of heme enzymes. Advances in Spectroscopy (R. J. H. Clark & R. E. Hester, Eds.) Wiley 13: p. 443-481 1986. 31. Kitagawa, T., Photoreduction of hemeproteins and iron porphyrins. Photomedicine and Photobiology 9: p. 15-25 1987. Kitagawa, T. Structure-function relationship of hemeproteins probed by 32. resonance raman spectroscopy. in International Scientific School "Spectroscopic and Structural Studies of Materials and Systems of Fundamental Importance to Biology and Medicine. 1987. Ustron. 33. Kitagawa, T. and K. Kamogawa. Application of raman difference spectroscopy to solution chemistry. in Workshop on Advanced Laser Raman Spectroscopy. 1987. Kanpur. 34. Kitagawa, T. and Y. Ozaki, Infrared and raman spectra of metalloporphyrins. Structure and Bonding 64: p. 71-114 1987. 35. Ogura, T., A. Maeda, M. Nakagawa, and T. Kitagawa, Transient resonance raman spectra of bacteriorhodopsin and halorhodopsin, in Primary processes in photobiology, T. Kobayashi, Editor. 1987, Springer-Verlag: Heidelberg. p. 233-241. 36. Kitagawa, T., The protein structure and iron-histidine stretching mode, in Biological applications of raman spectroscopy , T.G. Spiro, Editor. 1988, Wiley: New York. p. 97-131. 37. Kitagawa, T. Resonance raman studies of the structure and function of heme proteins. in The 39th Pittsburgh Conference and Exposition on Analytical Chemistry and Applied Spectroscopy. 1988. New Orleans. 38. Kitagawa, T. Iron-ligand stretching vibration and quaternary structure of hemoglobin. in International Symposium on Oxygen Binding Heme Proteins: Structure, Dynamics, Function and Genetics. 1988. Asilomar, California. 39. Kitagawa, T., T. Ogura, M. Nakagawa, and A. Maeda. Transient resonance raman spectra of bacteriorhodosin. in The 12th Taniqushi International Symposium, "Primary Process in Photobiology". 1988. Hakone. 40. Anzenbacher, P., J.H. Dawson, and T. Kitagawa, Heme enzymes examined by vibrational spectroscopy - role of the fifth heme iron ligand, in Spectroscopy of biological molecules - state of the art, A. Bertoluzza, C. Fagnano, and P. Monti, Editors. 1989, Esculapio: Bologna. p. 295-298. 41. Kamogawa, K. and T. Kitagawa, Application of raman difference spectroscopy to solution chemistry, in Vibrational spectra and structure, J.R. Durig, Editor. 1989. p. 447-472. 42. Kitagawa, T. Time-resolved uv resonance raman study of quaternary-struture change of haemoglobin. in IIIrd International Conference on Time-Resolved Vibrational Spectroscopy. 1989. Princeton, New Jersey. 43. Kitagawa, T. Time-resolved uv resonance raman study of quaternary structure change of hemoglobin. in IIIrd Europian Conference on Spectroscopy of Biological Molecules. 1989. Rimini, Italy. Kitagawa, T., S. Hashimoto, J. Teraoka, and Y. Tatsuno. Resonance raman 44. study of iron porphyrins with unusual oxidation states. in The 1989 International Chemical Congress of Pacific Basin Societies. 1989. Hawaii. 45. Kitagawa, T., S. Kamilnaka, and T. Ogura, Time-resolved uv resonance raman study of quaternary structure change of hemoglobin, in Spectroscopy of biological molecules - state of the art, A. Bertoluzza, C. Fagnano, and P. Monti, Editors. 1989, Esculapio: Bologna. p. 295-298. 46. Kitagawa, T. and A. Maeda, Vibrational spectra of rhodopsin and bacteriorhodospin. Photochem. Photobiol. 50: p. 883-894 1989. 47. Kitagawa, T., T. Ogura, V. Fidler, and Y. Ozaki. Mechanism of photoreduction of iron-porphyrins and hemeproteins. in The 1989 International Chemical Congress of Pacific Basin Societies. 1989. Hawaii. 48. Imai, K., K. Ishimori, K. Fushitani, G. Miyazaki, T. Kitagawa, Y. Wada, H. Morimoto, I. Morishima, D. Shih, J. Tame, and K. Nagai, Manipulation of hemoglobin function by protein engineering, in Protein structural analysis, folding and design, M. Hatano, Editor. 1990, Japan Sci. Soc. Press. p. 185-195. 49. Kitagawa, T. Pursuit of higher-order structural changes of protein by time-resolved ultraviolet resonance raman spectroscopy. in International Seminar on Photochemical Dynamics. 1990. Hamamatsu. 50. Kitagawa, T. and T. Ogura, Resonance raman spectra of transient species of a respiration enzyme detected with an "Artificial cardiovascular system" And raman/absorption simultaneous measurement system, in Laser applications in life sciences. 1990. p. 563-571. 51. Nagai, M., T. Kitagawa, and Y. Yoneyama, Molecular pathology of hemoglobin m saskatoon disease. Biomed. Biochim. Acta 49: p. 2/3 S317-S322 1990. 52. Kitagawa, T., Y. Mizutani, T. Tokutomi, and K. Aoyagi, Resonance raman spectra of pea intact phytochrome, in Spectroscopy of biological molecules, R.E. Hester and R.B. Girling, Editors. 1991, Royal. Soc. Chem. p. 423-426. 53. Kitagawa, T., Investigation of higher order structures of proteins by ultraviolet resonance raman spectroscopy. Prog. Biophys. Molec. Biol. 58: p. 1-18 1992. 54. Kitagawa, T., T. Egawa, T. Ogura, Y. Imai, R. Makino, and Y. Ishimura, Resonance raman studies of cytochrome p-450: The o-o stretching for p-450cam and the fe-co stretching for p-450(ω1) mutants, in Cytochrome p-450: Biochemistry and biophysics, A.I. Archakov and G.I. Bachmanova, Editors. 1992, INCO-TNC Joint Stock Corp.: Moscow. p. 83-88. Kitagawa, T., Y. Sakan, S. Kaminaka, T. Ogura, M. Nagai, and M. Ikeda-Saito, Time-resolved resonance raman investigation of photodissociation dynamics of liganded hemoglobin and myoglobin, in Time resolced vibrational spectroscopy v, H. Takahashi, Editor. 1992, Springer-Verlag: Tokyo. p. 10-13. 55. 56. Kitagawa, T., Characteristics at the heme locus of cytochrome p-450 in comparison with other oxygen-binding heme proteins, in Cytochrome p-450, T. Omura, Y. Ishimura, and Y. Fujii-Kuriyama, Editors. 1993, Kodansha: Tokyo. p. 31-44. 57. Kitagawa, T. and T. Ogura, Time-resolved resonance raman spectroscopy of heme proteins: Visible to uv and ns to ms, in Advances in spectroscopy, R.J.H. Clark and R.E. Hester, Editors. 1993, John Wiley: London. p. 139-188. 58. Kitagawa, T., Y. Sakan, T. Ogura, F.A. Fraunfelter, R. Matter, and M. Ikeda-Saito, Recombination dynamics of photodissociated co of myoglobin and its e7 mutants studied by time-resolved resonance raman spectrosocpy , in Frontiers of photobiology, A. Shima, et al., Editors. 1993, Excerpta Medica: Tokyo. p. 205-207. 59. Kitagawa, T., Y. Sakan, T. Ogura, F.A. Fraunfelter, R. Mattera, and M. Ikeda-Saito. Time-resolved resonance raman study of recombination intermediates of photodissociated co of myoglobin and its e7 mutants, in Laser spectroscopy of biological molecules. 1993. p. 187-190. 60. Kitagawa, T. and Y. Mizutani, Resonance raman spectra of highly oxidized metalloporphyrins and heme proteins. Coord. Chem. Rev. 135/136: p. 685-735 1994. 61. Sato, S. and T. Kitagawa, Time-resolved resonance raman study of porphyrins and metalloporphyrins in the electronic excited states. Appl. Phys. B59: p. 415-431 1994. Sato, S. and T. Kitagawa, Vibratinally hot (dd) excited states of nï'-porphyrin probed by picosecond time-resolved resonance raman spectroscopy , in Time-resolved vibrational spectroscopy vi, F.S. A. Lau and W. Werncke, Editors. 1994, Springer Proc. Phys. p. 104-108. 62. Kitagawa, T., S. Kaminaka, Y. Mizutani, K. Imai, and M. Nagai. Uv resonance raman studies of quaternary structures of hemoglobin using several mutants. in  VIth Europian Conf. Spectrosc. Biol. Mol. 1995: Kluwer Academic Pub. 63. 64. Kitagawa, T., T. Ogura, S. Hirota, D.A. Proshlyakov, K. Shinzawa-Itoh, S. Yoshikawa, and E.H. Appelman, Mechanism of dioxygen reduction at the iron-copper binuclear center of cytochrome c oxidase; time-resolved resonance raman study. J. Inorg. Chem. 59: p. 284 1995. 65. Kitagawa, T., T. Ogura, S. Hirota, D.A. Proshlyakov, K. Shinzawa-Itoh, S. Yoshikawa, and E.H. Appelman, Time-resolved resonance raman study on mechanism of dioxygen reduction by cotochrome c oxidase., in  Viith intrn. Conf. Time-resolved vib. Spectrosc., W.H. Woodruff, Editor. 1995: Los Alamos. Nagai, M., K. Imai, S. Kaminaka, Y. Mizutani, and T. Kitagawa, Uv resonance 66. raman studies of quaternary structure changes of human hemoglobin using a tyrosine α42 mutant. J. Inorg. Chem. 59: p. 347 1995. Nakashima, S., T. Kitagawa, and J.S. Olson, Time-resolved resonance raman study of the recombination dynamics photodissociated carbon monoxide to sperm whale myoglobin and its mutants. J. Mol. Liquids 65/66: p. 317-320 1995. 67. Kaminaka, S., A. Tsuneshige, T. Yonetani, and T. Kitagawa, Ultraviolet resonance raman study of fe-zn metal-hybrid hemoglobins as a t-state model, in Icors xv, S.A. Asher and P.B. Stein, Editors. 1996, John-Wiely: Chichester. p. 432-433. 68. Kitagawa, T., Y. Mizutani, Y. Uesugi, and S.G. Kruglik. Vibrational cooling of electronically excited metallo-porphyrins revealed by ps time-resolved resonance raman spectroscopy. in Annu. Meet. Korian Chem. Soc. 1996. 69. Kitagawa, T., S. Nakashima, Y. Mizutani, M. Mukai, and J.S. Olson, Resonance raman spectrosocpy of protein dynamics, in Icors xv, S.A. Asher and P.B. Stein, Editors. 1996, John-Wiely: Chichester. p. 426-427. 70. Kruglik, S.G., Y. Mizutani, V.A. Orlovich, and T. Kitagawa, Time-resolved stokes/anti-stokes resonance raman study of primary photoprocesses in the solutions of nickel-porphyrins, in Icors xv, S.A. Asher and P.B. Stein, Editors. 1996, John-Wiely: Chichester. p. 122-123. 71. Orlovich, V.A., Y. Uesugi, Y. Mizutani, S.G. Kruglik, A.G. Shvedko, and T. Kitagawa, Srs-based source of 3ps, 1 khz pulses in near-uv-visible spectral range for tr³ applications, in Icors xv, S.A. Asher and P.B. Stein, Editors. 1996, John-Wiely: Chichester. p. 1242-1243. 72. Horikoshi, N., S. Nagatomo, T. Kitagawa, and T. Kouzuma, Resonance raman spectroscopic studies of a copper-containing nitrite reductase from the alcaligenes xylosoxidans ncib 11015. J. Inorg. Biochem. 67: p. 46 1997. 73. Kitagawa, T., Vibrational spectroscopy-principles for measurements and examples of their applications (in japanese), in Structural biology and its analysis. 1997, Kyoritsu Shuppan. 74. Kitagawa, T. and T. Ogura, Oxygen activation mechanism at binuclear site of heme-copper oxidase superfamily as revealed by time-resolved resonance raman spectroscopy. Prog. Inorg. Chem. 45: p. 431-479 1997. 75. Kitagawa, T., T. Ogura, S. Hirota, D.A. Proshlyakov, J. Matysik, E.H. Appelman, K. Shinzawa-Itoh, and S. Yoshikawa, Time-resolved resonance raman study of dioxygen reduction by cytochrome c oxidase. J. Inorg. Biochem. 67: p. 6 1997. 76. Kouzuma, T., N. Horikoshi, S. Suzuki, S. Nagatomo, and T. Kitagawa, Electron-transfer reactions and resonance raman spectroscopic studies of two 77. distinct azurins from alcaligenes xylosoxidans ncib 11015. J. Inorg. Biochem. 67: p. 45 1997. Nagano, S., M. Tanaka, K. Ishimori, I. Morishima, Y. Watanabe, M. Mukai, T. Ogura, and T. Kitagawa, Catalytic roles of the distal site hydrogen bond network of peroxidases, in Oxygen homeostasis and its dynamics, Y. Ishura, H. Shimada, and M. Suematsu, Editors. 1997, Springer-Verlag. p. 354-358. 78. Ogura, T., M. Aki, and T. Kitagawa, A third-generation uv resonance raman spectrophotometer using solar-blind iccd and a guasi-cw uv light source for biological applications. J. Inorg. Biochem. 67: p. 428 1997. 79. Ogura, T., Y. Kobayashi, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, A ph dependent polarity change at the heme a 3 -cu b site of bovine cytochrome c oxidase probed through the fe-co stretching raman band. J. Inorg. Biochem. 67: p. 107 1997. 80. Oqura, T., D.A. Proshlyakov, J. Matysik, E.H. Appelman, K. Shinzawa-Itoh, S. Yoshikawa, and T. Kitagawa, Mechanism of dioxygen reduction by cytochrome c oxidase as studied by time-resolved resonance raman spectroscopy. , in Oxygen homeostasis and its dynamics, Y. Ishura, H. Shimada, and M. Suematsu, Editors. 1997, Springer-Verlag. p. 102-105. 81. Tsukui, H., E. Suzuki, S. Nagatomo, T. Kitagawa, Y. Sugimura, F. Yoshizaki, and T. Kouzuma, Gene expression and characterization of a novel plastocyanin from the cyanobacterium synechococcus sp. Pcc7942. J. Inorg. Biochem. 67: p. 48 1997. 82. Kitagawa, T. Mechanism of oxygen reduction by cytochrome c oxidase: Time-resolved resonance raman study. in 216th American Chemical Society Meeting Inorganic and Physical; Symposium on Multinuclear enzymes in oxygen metabolism. 1998. Boston. 83. Kitagawa, T., Y. Mizutani, Y. Uesugi, and S. Kruglik. Picosecond resonance raman study of excited state dynamics of ni(ii)-porphyrins in solutions. in  VIIIth International Conference on Spectroscopy and Chemistry of Porphyrins and Their Analogs. 1998. Minsk. 84. Kitagawa, T., M. Mukai, M. Nagai, and J.S. Olson. Uv resonance raman spectra of hemoglobin and myoglobin. in International Conference on Oxygen Binding and Oxygen Activation/Sensing Heme Proteins. 1998. Asilomar. 85. Kitagawa, T. and T. Ogura, Time-resolved resonance raman investigation of oxygen reduction mechanism of bovine cytochrome c    oxidase. J. Bioenerg. Biomemb. 30: p. 71-79 1998. 86. Kitagawa, T. and T. Ogura, Time-resolved resonance raman study of dioxygen reduction by cytochrome c   oxidase. Pure Appl. Chem. 70: p. 881-888 1998. 87. Kitagawa, T. and T. Ogura. Time-resolved resonance raman characterization 88. of reaction intermediates of bovine cytochrome c oxidase. in 10th Europian Bioenergetics Conference. 1998. Goteborg. 89. Kitagawa, T., T. Ogura, S. Hirota, D.A. Proshlyakov, J. Matysik, E.H. Appelman, K. Shinzawa-Itoh, and S. Yoshikawa, Time-resolved resonance raman study of dioxygen reduction by cytochrome c   oxidase. "Oxygen Homeostasis and Its Dynamics" (Y. Ishimura, H. Shimada, and M. Suematsu eds.) Springer-Verlag, Tokyo: p. pp. 57-71 1998. 90. Kitagawa, T., X. Zhao, and M. Okamura. Resonance raman spectra of q a and qь and their semiquinone radicals in photosynthetic reaction center from rb. Sphaeroides r26. in US-Japan Symposium on Proton Coupled Electron Transfer. 1998. Kona Royal Resort, Kona, Hawaii. 91. Mizutani, Y. and T. Kitagawa. Cooling behavior of the fe-histidine bond of heme heated by photodissociation of carbonmonoxy myoglobin. in International Conference on Time-Resolved Vibrational Spectroscopy. 1999. Biosphere-2, Tucson. 92. Mizutani, Y. and T. Kitagawa. Observation of non-uniform intensity rise among anti-stokes bands of nickel octaethylporphyrin in the (d,d) excited state. in International Conference on Time-Resolved Vibrational Spectroscopy. 1999. Biosphere-2, Tucson. 93. Mizutani, Y., K. Yamamoto, and T. Kitagawa, Fast protein dynamics probed by vibrational spectroscopy. in "Old and New Views of Protein Folding" (Ed. K. Kuwajima and M. Arai), Intrl. Congr. Series 1194,   Elsevier Science B.V.: p. 85-94 1999. 94. Mizutani, Y., K. Yamamoto, and T. Kitagawa, eds. Fast protein dynamics probed by vibrational spectroscopy. Old and new views of protein folding, ed. K. Kuwajima and M. Arai. 1999, Elsevier Science B. V.: Tokyo. 85-94. 95. Yamamoto, K., Y. Mizutani, and T. Kitagawa. Time-resolved raman spectra of protein solutions observed with a novel nanosecond temperature jump apparatus. in International Coference of Time-Resolved Vibrational Spectrscopy. 1999. Biosphere-2, Tucson. 96. Kitagawa, T., Structures of reaction intermediates of cytochrome c oxidase probed by time-resolved vibrational spectroscopy. J. Inorg. Biochem. 82: p. 9-18 2000. 97. Kitagawa, T., Progress report on molecular biometallics (1996-2000), a project of the priority areas for research under the auspices of the japanese government. J. Biol. Inorg. Chem. 5: p. 410-415 2000. 98. Mizutani, Y. and T. Kitagawa, Ultrafast dyamics of myoglobin probed by time-resolved resonance raman spectroscopy. The Chem. Rec. 1: p. 258-275 2001. Mizutani, Y. and T. Kitagawa, A role of solvent in vibrational energy relaxation of metalloporphyrins. J. Mol. Liquid 90: p. 232-242 2001. 99. Mizutani, Y. and T. Kitagawa, Vibrational energy relaxation of metalloporphyrins in a condensed phase probed by time-resolved resonance raman spectroscopy. Bull. Chem. Soc. Jpn. 75, 623-639 2002. 100. Kitagawa, T., Overview icpp-2: Resonance raman spectra. J. Porphyrins and Phthalocyanines 6: p. 301-302 2002. 101. Kitagawa, T. and S. Hirota, Raman spectroscopy of proteins, in The handbook of vibrational spectroscopy (j. M. Chalmers and p. R.    Griffiths, eds.). 2002, John Wiley & Sons: Chichester. p. 3426-2446. 102. Aono, S., H. Nakajima, T. Ohta, and T. Kitagawa, Resonance raman and ligand-binding analysis of the oxygen-sensing signal transducer protein hemat from bacillus subtilis. Methods in Enzymology 381: p. 618-628 2004. 103. Hiramatsu, H. and T. Kitagawa, Ft-ir approaches on amyloid fibril structure. Biochim. Biophys. Acta 1753: p. 100-107 2005. 104. Ohta, T. and T. Kitagawa, Resonance raman investigation on the specific sensing mechanism of a target molecule by gas sensory proteins. Inorg. Chem. 44: p. 758-769 2005. 105. Uchida, T. and T. Kitagawa, Mechanism for transduction of the ligand-binding signal in heme-based gas sensory proteins reavealed by resonance raman spectroscopy. Acc. Chem. Res. 38 : p. 662-670 2005. 106. Nagatomo, S., M. Nagai, and T. Kitagawa  Resonance Raman Investigation of Quaternary Structure Change in Hemoglobin upon Ligand Binding, in 'Hemoglobin : Recnt Development and Topics' (M. Nagai, ed.) Research Signpost; Kerala, India. p.37-61, 2011. 107. Li, J. and T. Kitagawa, Applications of Vibrational Spectroscopy in the Study of Flavin-based Photoactive Proteins. Spectroscopy, 25. 261-269, 2011. 108. Li, J. and Kitagawa, T., Resonance Raman Spectroscopy, in Methods in Molecular Biology; Flavins & Flavoproteins (2012). 109. Nakashima, S., T. Ogura and T. Kitagawa, Infrared and Raman Spectroscopic Investigation of the Reaction Mechanism of Cytochrome c Oxidase. Biochim. Biophys. Acta, 1847, 86-97, 2015. 110.