Aperio GT 450Specifications

MAN-0393, Revision H | March 2022

Aperio GT 450 Specifications
This manual applies to Aperio GT 450 Controller, Aperio GT 450 Console, and Aperio GT 450 SAM versions 1.1and later

Copyright NoticeÌ Copyright © 2019-2022 Leica Biosystems Imaging, Inc. All Rights Reserved. LEICA and the Leica logo are registered trademarks of Leica
Microsystems IR GmbH. Aperio, GT, and GT 450 are trademarks of Leica Biosystems Imaging, Inc. in the USA and optionally in othercountries. Other logos, products, and/or company names might be trademarks of their respective owners.

Ì This product is protected by registered patents. For a list of patents, contact Leica Biosystems.

Customer ResourcesÌ For the latest information on Leica Biosystems Aperio products and services, please visit www.LeicaBiosystems.com/Aperio.

Contact Information – Leica Biosystems Imaging, Inc.
Headquarters
Leica Biosystems Imaging, Inc.
1360 Park Center Drive
Vista, CA 92081
USA
Tel: +1 (866) 478-4111 (toll free)Direct International Tel: +1 (760) 539-1100

Customer Support

General Information

Contact your local support
representative with any query andservice request.

US/Canada Tel: +1 (866) 478-4111 (toll free)Direct International Tel: +1 (760) 539-1100
Email: ePathology@LeicaBiosystems.com

https://www.leicabiosystems.com/
service-support/technical-support/

23GT450, 23GT450SAM

2Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

ContentsNotices................................................................................................................................ 4

Revision Record.......................................................................................................................................4Cautions and Notes..................................................................................................................................4Introduction............................................................................................................................. 6Aperio GT 450 Scanner Specifications................................................................................ 6General Scanner Specifications...................................................................................................................6Aperio GT 450 Features.............................................................................................................................7
Performance Specifications.........................................................................................................................7Power Specifications.................................................................................................................................8Slides and Racks Specifications...................................................................................................................8Environmental Specifications......................................................................................................................9Network Specifications............................................................................................................................10Aperio GT 450 Scanner Administration Manager (SAM) Server Specifications............. 10
Viewing Station Specifications............................................................................................11Client Workstation.................................................................................................................................. 11Monitor ..............................................................................................................................................................................11

Aperio GT 450 Compliance Specifications........................................................................ 12
Aperio GT 450 Network Configuration............................................................................... 13

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

3

Notices

Notices
Revision RecordRev.

IssuedSections AffectedH

March 2022

“Aperio GT 450 Hardware
Updated SAM server specifications to Windows Server 2019Specifications” andand updated scanner environmental specifications.
“Aperio GT 450 ScannerAdministration Manager(SAM) Server Specifications”

GMarch 2021

“Aperio GT 450 Scanner
Removed SAM Server model number to accommodate multiple
Administration Manager
SAM server models.
(SAM) Server Specifications”

F

December 2020

“Aperio GT 450 Scanner
Clarified that a VM can be used for SAM.
Administration Manager(SAM) Server Specifications”

E

April 2020

“Viewing StationSpecifications”

Adjusted number of monitors to accommodate multiple viewing
station models.

DFebruary 2020

“Aperio GT 450 Network
Configuration”

Corrected typographical error in diagram.

COctober 2019

“Aperio GT 450 HardwareSpecifications”

Corrected JPEG2000 to JPEG.

BJuly 2019

Introduction and “AperioGT 450 Hardware
Specifications”

Updated scanning throughput speed.

AJune 2019

AllNew document.

DetailCautions and Notes

4`Serious Incidents Reporting - Any serious incident that has occurred in relation to the Aperio GT 450 shall bereported to the manufacturer and the competent authority of the member state in which the user and/or the patientis established.

`Specifications and Performance - For device specifications and information on performance characteristics,
refer to this document, Aperio GT 450 Specifications.

`Installation - Aperio GT 450 must be installed by a trained Leica Biosystems Technical Services representative.

`Repair - Repairs may be done only by a trained Leica Biosystems Technical Services representative. After repairs
are done, ask the Leica Biosystems technician to perform operation checks to determine the product is in good
operating condition.

`Accessories - For information on using Aperio GT 450 with third-party accessories such as a Laboratory
Information System (LIS) not provided by Leica Biosystems, contact your Leica Biosystems Technical Services
representative.

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

Notices`Quality Control - For information on image quality checks, see the Aperio GT 450 User’s Guide.

`Maintenance and Troubleshooting - For information on maintenance and troubleshooting problems, see theAperio GT 450 User’s Guide.

`Cybersecurity - Be aware that workstations are susceptible to malware, viruses, data corruption, and privacy
breaches. Work with your IT administrators to protect workstations by following your institution’s password andsecurity policies. For Aperio recommendations on protecting your workstations and servers, see the document
Aperio GT 450 IT Manager and Lab Administrator Guide.
To protect workstations from malware intrusion, use caution when inserting USB drives and other removabledevices. Consider disabling USB ports that are not in use. If you plug in a USB drive or other removable device, you
should scan the devices with an anti-malware utility.
If a suspected Aperio GT 450 cybersecurity vulnerability or incident is detected, contact Leica Biosystems TechnicalServices for assistance.

i`Training - This manual is not a substitute for the detailed operator training provided by Leica Biosystems or forother advanced instruction.

`Safety - Safety protection may be impaired if this device is used in a manner not specified by the manufacturer.
For additional information on this product, including intended use and symbols glossary, please refer to theprimary instructions for use, Aperio GT 450 User’s Guide.

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 20225Introduction
This document lists the latest specification information for the Aperio GT 450 scanner. For details on using this device, referto the Aperio GT 450 User’s Guide.
The Aperio GT 450 is a high performance, brightfield whole slide scanner that includes continuous loading with 450 slidecapacity across 15 racks, priority rack scanning, automated image quality check and a scan speed of ~32 seconds at 40x
scanning magnification for a 15 mm x 15 mm area.
This system is intended for use by trained histotechnicians, IT professionals, and pathologists. Ensure you follow appropriate
good laboratory practices and the policies and procedures required by your institution for slide preparation, processing,storage, and disposal. Use this equipment only for this purpose and in the manner described in the Aperio GT 450 User’sGuide.

Component

Description

Scanner Administration Manager (SAM) Server

The SAM server connects to multiple Aperio GT 450 scanners and runs theSAM Client Application Software. For requirements for this server, see “Aperio
GT 450 Scanner Administration Manager (SAM) Server Specifications” on page10.

SAM Client Application Software

The Scanner Administration Manager (SAM) client application software
enables IT implementation, PIN configuration, and service access of multiple
scanners from a single desktop client location for IT professionals.

Aperio Viewing Station

The viewing station includes calibrated monitor(s) and a workstation withAperio ImageScope version 12.4 or higher. For requirements for the viewing
station see “Viewing Station Specifications” on page 11.

Aperio GT 450 Scanner Specifications
The following sections contain specifications for the Aperio GT 450.
Routine setup and functional verification is required by a Leica Biosystems Service representative after shipping.

General Scanner Specifications
Feature6Details

Part number23GT450

Scanner on/off switch

Located on the right side, near the back of the scanner.

Scanning region≤ 23.6 mm x 58 mm

Objective lensCustom optics by Leica Microsystems for native 40x scanning with 1 mm FOV (Field of View).

Brightfield imaging

4k Trilinear camera

Overview image
resolution

13 µm/pixel for label, barcode, and tissue macro (overview image).

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

﻿Feature

Details

Label/barcode imaging

High resolution main imaging camera used to capture the label/barcode region.

Focusing system

Real-time automatic focusing (U.S. Patent 9841590B2).

Digital slide file format

Standard pyramid tiled TIFF with JPEG image compression.

Illumination

White LED

Operating system

LinuxConnections

The Aperio GT 450 has two connectors on the back panel: 1) Power. The appropriate power
cord for your geographical region is shipped with the scanner. The power cord plugs into theAC/DC adapter that connects to the back panel. Only use the approved power cord supplied by
the manufacturer. 2) Network. You will need to supply your own network cable.
Laser Compiiance. This product is a Class 1 Laser Product and is in compliance withinternational standards and US requirements.

Aperio GT 450 Features
FeatureDetails

Scanning priority

By rack, up to 3 racks at a time.

Continuous loading

Continuous rack loading without interrupting scanning.

Slide loading

Automatic: up to 450 1-inch x 3-in (2.54 cm x 7.62 cm) slides.

Slide calibration

Each slide scan is automatically calibrated.

Automated imagequality check

Each scan image is automatically checked for image quality during scanning.

Tissue finding

Automatic

Touch-screen

y 10.1” diagonal, IPS, 16:10, 1280 x 800 resolutiony Viewing angles: 85/85/85/85
y Contrast ratio: 800:1

Embedded Vision
Processing Unit (VPU)

The VPU is an embedded processor that runs the Aperio GT 450 controller software. Referto the GT 450 IT Manager and Lab Administrator Guide for instructions on determining theversion of the software included on this unit.

Performance Specifications
FeatureDetails

Scan speed< 32 sec/slide, 15 mm x 15 mm at 40x.

Throughput

Sustained throughput 81 slides per hour 15 mm x 15 mm (40x).

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

7﻿FeatureScanning resolution

Details
0.26 µm/pixel at 40x.

Power Specifications
FeatureInput Power

Details
External AC/DC adapter (Power Supply Unit): 100-240V, 50/60Hz, 5A max;
Instrument: 24V

10.5A

Power consumption+24vdc @ 10.5 amps RMS

Uninterruptible Power
Supply (UPS)

To protect the scanner, Leica Biosystems recommends using a UPS rated at 2200VA withpower conditioning that protects connected loads from electrical surges and spikes, lightningand other power disturbances. The UPS allows the scanner to run for an additional 20-30
minutes, giving you time to safely shut it down.

Slides and Racks Specifications
FeatureSlides accepted

Details
The Aperio GT 450 is optimized for scanning glass slides with coverslips affixed with mounting
media.
y 1-inch x 3-inch (2.54 cm x 7.62 cm) glass slides. Measurements comply with ISO 8037/1.
y Minimum slide size: 25 mm (wide) x 75 mm (long)y Maximum slide size: 26 mm (wide) x 76 mm (long)y Thickness: Optimized for range of 0.9 mm to 1.1 mm, excluding coverslip
The coverslip/label shall not protrude beyond the edge of the glass slide. The entire coverslip
and label must be adhered to the glass slide. There must be no lifted edges or parts of thecoverslip/label. The outer surface of the slide must be dry.
Slides are typically prepared using:y Glass coverslip with mounting media such as Eukitty Film coverslip with integrated glue
Maximum tissue thickness (including mounting media) optimized for 3-5 µm.

Coverslips accepted

8

Optimized for coverslip with thickness of .17 mm, made of typical coverslip material: Standard
microscope cover glass or Cellulose Tri-Acetate film (microscope cover film).

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

﻿Feature
Label area

Details
25 mm x 25 mm. Handwritten/printed non-transparent, matte (paper-like reflecting) sticker.
Labels shall not protrude beyond the edge of the slides or be lifted.
Labels shall not be attached to the bottom of the slide, but only attached to the coverslip-sideof the slide.
Maximum label thickness 200 microns
Minimum label size 12 mm x 25 mm
There must be a minimum of 0.5 mm between each side of the barcode and the edge of thelabel.

Racks accepted

Optimized and recommended for use with Leica HistoCore Spectra workstation racks (stainerand coverslipper), which include the Leica Universal Rack 30-slide capacity. Sakura PrismaStainer and Coverslipper Rack 20-slide capacity racks also accepted.

Racks provided

15 Leica Universal racks, 30-slide capacity (part number 23RACKGT450) are provided with theAperio GT 450.

Barcodes supported

NW7
QR CodeData Matrix
Interleaved 2 of 5
Code 39
Code 128
PDF417MicroPDF417

Environmental Specifications
FeatureDetails

Dimensions

20.8” (52.83 cm) Width x 28” (71.2 cm) Depth x 19.5” (49.53 cm) Height

Weight

140 lbs (63.5 kg)

Work surface
specifications andrequired clearancesStandard laboratory grade work bench with at least 24” (61 cm) Width x 28” to 32” (71.12 cm
to 81.28 cm) Depth x 29.25” (74.3 cm) Height, open area leveled to +/- 1.0 degrees. Ensure
you leave 13 inch (33 cm) clearance on the left side of each scanner to provide access formaintenance activities, and leave 3-4 inches (8 cm-10 cm) on the right side of each scanner foraccess to the power switch.

Operating conditions

The Aperio GT 450 is designed to be operated under the following environmental conditions:y Indoor use
y Overvoltage Category II
y 0% - 80% humidity, non-condensing
y Operating temperature: 15-30° C (59-86° F)

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

9﻿FeatureDetails

Storage conditions+5 to 40° C, 5 to 85% RH

Transport conditions

0 - 50° C, 10% - 95% humidity, non-condensing

System heat dissipation

Maximum 870 BTU/hr.

Altitude

Maximum elevation 10,000 ft

Degree of pollution

2

Environmental

RoHS conform (Restriction of Hazardous Substances) according to Directive 2011/65/EU

Network Specifications
FeatureNetwork interface

Details
1 gigabit per second Ethernet

Bandwidth requirements For the connection between the Aperio GT 450 and the SAM server, the required minimum
bandwidth is a gigabit ethernet with a speed equal to or greater than 1 gigabits per second(Gbps) with no more than 60ms of latency. For the connection between the SAM server andthe image repository (DSR), the required minimum bandwidth is 10 gigabits per second and nomore than 16ms of latency.

Aperio GT 450 Scanner Administration Manager (SAM) Server Specificationsi

The Scanner Administration Manager (SAM) supports up to 4 Aperio GT 450 scanners. Multiple SAM
servers can be added to your network.

For information on network configuration and data flow in the Aperio GT 450 system, refer to “Aperio GT 450 Network
Configuration” on page 13 and the Aperio GT 450 IT Manager and Lab Administrator Guide.

FeatureDetails

CPUIntel Xeon Silver 4114 2.2G, 10C/20T, 9.6GT/s, 14M Cache, Turbo, HT (85W) DDR4-2400

Hard disk space(2) 800GB SSD SATA Mix Use 6Gbps 512n 2.5in Hot-plug Drive, Hawk-M4E,3 DWPD,4380 TBWMemoryMemory DIMM Type and Speed Quantity: (2) 16GB 2666MT/s RDIMMs

Network card

Broadcom 57416 2 Port 10Gb Base-T + 5720 2 Port 1Gb Base-T, rNDC

Operating system

Windows Server 2019

You may purchase your own server or provide a virtual server to host the SAM application software.

10Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022﻿Viewing Station Specifications
The viewing station (part number 23VS101) uses calibrated monitor(s) and a workstation with Aperio ImageScope version
12.4 or higher.
A viewing station is optional and is not included in the Aperio GT 450 base product. The following specifications arerequired for optimal image viewing.

Client WorkstationFeatureDetails

CPU speedIntel Core 2 Duo (or newer) processor, running at 3.9 GHz or faster

Hard disk space

80GB free disk space

Memory8GB or more recommended

Network card

1 Gigabit network card or fasterVideo card

24-bit color at monitor’s resolution

Operating system

Windows 7 64-bit and later

MonitorFor best image quality during viewing, a calibrated monitor must be used.
The monitor(s) included in the Aperio Viewing Station are calibrated to a Leica internal specification which is specific forstain colors and optimized for digital slide viewing by pathologists. However, if you purchase your own monitor, calibratingto sRGB standards will give an acceptable viewing experience.

FeatureDetails

Display type

LCD (flat panel)

Screen resolution

1920(h) x 1200(v) pixels

Screen size

24 inch (60 cm) or larger

Color support

16.7 million colors

Color depth

24-bitBrightness

300 cd/m2, 180 cd/m2 (DICOM preset)

Contrast ratio

1000:1

Calibration

A calibrated monitor must be used

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 202211﻿Aperio GT 450 Compliance Specifications
This device complies with Part 15 of the FCC rules. Operation is subject to the following two conditions: (1) This device may
not cause harmful interference and (2) this device must accept any interference received, including interference that may
cause undesired operation.
This device has been evaluated against and conforms to the following standards:

FeatureDetails

SafetyIEC 61010-1:2010
IEC 61010-1:2010/AMD1:2016
IEC 61010-2-081:2018
UL 61010-1:2012/R:2019-07
UL 61010-2-081:2019
CAN/CSA C22.2 No. 61010-1:2012/A1:2018
CAN/CSA C22.2 No. 61010-2-081:2019
EN EIC 61010-2-081:2020
EN 61010-1:2010/A1:2019
EMC

12EN 61326 (Emissions)
VCCI CISPR 32
KN 32
FCC/IC

Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

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Aperio GT 450 Network Configuration
This section contains information on how the Aperio GT 450 fits into your network for optimized scanning and image viewing
performance. For more details on this topic, see the Aperio GT 450 IT Manager and Lab Administrator Guide.

Aperio GT 450 Scanner

Image Data
TCP 2762

Config Data
Port 44386

Image
Metadata Port44386

Time
Synchronization Port 123

SAM DataServer

MirthEventsLog Data

Events

DICOM Converter

Config Data

Event Data Ports6662, 6663

SAM Server File System

SQL ServerDatabase

SAM Server
Secured Port 443

Image Metadata
Port 44386

Image Data UDP 137, 138
TCP 139, 445

SAM Web Page

Aperio eSlide Manager DataServer

Image Server File System

DSR ServerAperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

13﻿

Data Type
Image Data

Description

Port

The Scanner sends DICOM image data to the DICOM Converter. The data is sent using
TLS encryption.

TCP 2762

Configure the communication between the scanner and the DICOM converter using theHostname and Port settings on the Images configuration page.
The DICOM Converter sends the image data (either as a converted SVS file, or as raw
DICOM data) to the Image File System on the DSR Server. The data is sent using SMB3
Encryption.
Configure the communication between the DICOM converter and the DSR using the FileLocation setting on the Images page.
Scanner
Configuration
Data

The scanner sends a call to the SAM DataServer to request configuration data. The
SAM DataServer returns the configuration data to the scanner. The data is sent using
TLS Encryption. Communication between the scanner and the SAM DataServer isconfigured on the scanner.

UDP 137,138TCP 139,44544386

The SAM DataServer stores the configuration data on the SQL Server Database on theSAM Server.
The SAM DataServer displays the configuration data through the SAM web page.
TimeSynchronization

Timeclock synchronization between SAM and Multiple Scanners is maintained using
network time protocol.

UDP 123

Image Metadata The Scanner sends Image Metadata to the SAM DataServer. The data is sent using TLS 44386
encryption. Communication between the scanner and the SAM DataServer is configuredon the scanner.
The SAM DataServer sends image metadata to the Aperio eSlide Manager DataServer
located on the DSR. The data is sent using TLS encryption.
Configure the communication between the SAM DataServer and the scanner using theHostname and Port settings on the DSR page.
Messaging andEvent Data

The scanner sends logs and event data to the Mirth Connect Server. No sensitive datais transferred.

6662,
6663

Configure the communication between the scanner and the Mirth Connect Server on the
Event Handling configuration page.
The Mirth Connect Server copies critical event and error data to the SAM DataServerthen the SAM DataServer sends this data to the SQL database. This is the datareported out via the SAM Event Logs.
The SAM DataServer displays the event data through the SAM web page.
Mirth Connect Server processes the Log data and appends the Event Log, which resides
on the file system. The communication between Mirth and the Event Log is configured
within the Mirth Application setup. It is not accessible through the SAM.

14Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

﻿Aperio GT 450 Specifications, Revision H © Leica Biosystems Imaging, Inc. 2022

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