Wheezing Bronchial asthma mainly manifests as wheezing and shortness of breath are main
symptoms of bronchial. Patients with asthma. Asthmatics showedshow increased superoxide
generation from leuckocytes, as well as and increased lipid peroxidation product, indicatingproducts, both of which indicate increased oxidative stress. Ascorbic acid is an importantantioxidant which that directly neutralizes free radicals,; thus therefore, it is continuously

Comment [A1]: The sentence has beenrearranged for more emphasis on “bronchial asthma”
as it is the core topic on which the study is based.
Comment [A2]: The APA encourages the use ofunbiased language by avoiding language that may
equate a person with his or her condition, e.g.,diabetic, epileptic, schizophrenic, and asthmatic. As
such, it is preferable to use the phrase “patients withasthma.”usually utilizedused to maintain thea redox state in the lungs of lung inpatients with asthma.
According to Hatch et al suggested that ., ascorbic acid is the major antioxidant substancepresent in the airway surface lining of the lung,lungs and may protect against endogenous aswell asand exogenous oxidants. OurW present finding ofe found that the presence of a low
ascorbic acid level in wheezing children couldwith wheezing may be attributed to its normal
physiological function and, elevatedincreased utilization to overcome the continuous
generation of oxidant radicals and also and to neutralize the exogenous oxidant. It has beensuggested thatoxidants. Therefore, ascorbic acid deficiency may be either an underlying
factor in the pathophysiology of asthma or a a response to asthmatic airwaysairway
inflammation. Our in patients with asthma. Consistent with our findings of , other studies
have also reported a low ascorbic acid level in wheezing children with wheezing is inagreement with the earlier reports of; these researchers have who attributed such kind ofloweringthe decrease in the plasma ascorbic acid level in plasma to its normal physiological
function i.e., its utilizationfunctions in maintaining the maintenance ofbody’s defense
mechanism, tissue and in the integrity and, replacement, and healing process.processes oftissues. Destruction of the respiratory mucous membrane during common cold and resulting
reduction of the consequent decrease in tissue ascorbic acid, levels may further delay in thehealing of the mucous membrane surface leading and result in to prolonged asthma
symptoms of asthma. A study shows that reported decreased serum levels of antioxidant
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Comment [A3]: To create an easy flow of ideas,transition words such as however, therefore,moreover, etc. can be used. This usage enhances
coherence of ideas in the paragraph and themanuscript on the whole. Note that at this instance,
we have added the transition word “therefore” toenhance the logical flow and overall clarity.

vitamins are decreased in the sera of asthmatic patients with asthma, even during theasymptomatic periodsperiod of the disease, and thus. Therefore, this decrease is does nottotally dependentcompletely depend on the increased oxidative stress, as reflected by lipid
peroxidation products.

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