To dateCurrently, there is growing number of there are several well-known predictors ofmalignancy of the thyroid nodule malignancys; these include including a solid, fixed
formation tumors that is are detected by on physiological examination, rapid growth, andlarge sizeenlargement of the site, tracheostomy, dysphagia, or lymphadenopathy, history ofirradiation with in the history of low doses of radiation toof the head and neck during infancy,
age less for <20 years and or more than >70 years, and male gender. Detection Timely
detection of thyroid tumors, that are characterized by a benign course and favorable
prognosis, can significantly reduce the number of surgical interventions required. However,in somethere are cases, where the malignant potential of malignancy of the tumor cannotcan
not be determined and. In this case, alternative diagnostic methods are required. These suchas those mayinvolving include the detection of BRAF and RAS spot point mutations and,PAX8/ / PPAR γ? and RET/ / PTC translocations are required. However, , but given the highComment [A1]: Here, the text has been revised tojoin two sentences for better flow and for brevity.

cost of genetic testingresearch data and relatively low sensitivity, these methods are notalways suitable for routine diagnostics. DeterminationThe determination of the level of serum
hormone levelshormones may be cheaper more cost-effective and yield faster results. This
review is devoted to the assessesment of the role ofcurrent concept on thyroid- stimulating
hormone (TSH) role in the development and progression of differentiated thyroid cancer,
namely papillary thyroid carcinoma. Numerous studies have demonstrated reported thesignificance of high (TSH) level in the malignization of thyroid nodulesnodes malignisationand disease progression associated with rapid growth, aggressiveness, and metastasis
development.. Many authors have found TSH levelfind this test to be useful for
distinguishing between benign and malignant thyroid tumors and have suggested that it may
can be used as an auxiliary diagnostic biomarker for thyroid tumors.in the diagnostics.
However, there some authors havewho did not fouind any no relationship correlation between
TSH level and thyroid cancer. Finally, there is a growing body of investigations evidence onAll material in this document is the intellectual property of Crimson Interactive Pvt. Ltd. The use of informationand content in this document in whole or in part is forbidden unless express permission has been given inwriting by Crimson Interactive Pvt. Ltd.

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Comment [A2]: The use of “suggest” and “may”
in the same sentence is redundant in this context asboth words denote a possibility.
Comment [A3]: A comma should be used after
transition words such as therefore, however,moreover, nevertheless, hence.

opposing associationsdemonstrating the opposite relations between TSH levels and thyroid
malignanciescancers. Nevertheless, some geneticGenetic studies support also are in favor of
the presence of a reciprocal association between TSHthe levels of TSH and the developmentof thyroid cancer development.

All material in this document is the intellectual property of Crimson Interactive Pvt. Ltd. The use of informationand content in this document in whole or in part is forbidden unless express permission has been given inwriting by Crimson Interactive Pvt. Ltd.

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