研究業

績リス

ト【原著論文】
1. Hossain MZ, Bakri MM, Yahya F, Ando H, Unno S, Kitagawa J: The Role ofTransient Receptor Potential (TRP) Channels in the Transduction ofDental Pain. Int J Mol Sci, 20: E526, 2019.
2. Hossain MZ, Ando H, Unno S, Masuda Y, Kitagawa J: Activation of TRPV1and TRPM8 Channels in the Larynx and Associated Laryngopharyngeal
Regions Facilitates the Swallowing Reflex. Int J Mol Sci, 19: E4113,2018.
3. Matoba H, Kanayama H, Kato T, Hossain MZ, Kitagawa J, Takehana Y, Yamada
K, Masuda Y: Temporal change in the occlusal vertical dimension and its
involvement in modulation of jaw movement in bite-reduced animals. JOral Sci, 60: 170-176, 2018.
4. Kamimura R, Hossain MZ, Unno S, Ando H, Masuda Y, Takahashi K, Otake
M, Saito I, Kitagawa J: Inhibition of 2-arachydonoylgycerol degradation
attenuates orofacial neuropathic pain in trigeminal nerve-injured mice.
J Oral Sci, 60: 37-44, 2018.
5. Bakri MM, Yahya F, Munawar KMM, Kitagawa J, Hossain MZ: Transient
receptor potential vanilloid 4 (TRPV4) expression on the nerve fibersof human dental pulp is upregulated under inflammatory condition. ArchOral Biol, 89: 94-98, 2018.
6. Ando H, Imamura Y, Tadokoro O, Hossin MZ, Unno S. Sogawa N. Kondo E,Kitagawa J: Expression of Calcium-Binding Proteins, Calbindin D28k andCalretinin, in the Frog Taste Receptor Structures. Neurophysiology, 49:
254-260, 2017.
7. Hossain MZ, Unno S, Ando H, Masuda Y, Kitagawa J: Neuron-Glia Crosstalkand Neuropathic Pain: Involvement in the Modulation of Motor Activity
in the Orofacial Region. Int J Mol Sci, 18: E2051, 2017.
8. Zakir HM, Shinoda M, Unno S, Ando H, Masuda Y, Iwata K, Kitagawa J:
Involvement of microglia and astroglia in modulation of the orofacial
motor functions in neuropathic-pain rats. J Oral Biosci, 59: 17-22,
2017.
9. Bakri MM, Hossain MZ, Razak FA, Saqina ZH, Misroni AA, Murat NA, Kitagawa
J, Saub RB: Dentinal tubules occluded by bioactive-glass containing
toothpaste exhibit high resistance toward acidic soft drink challenge.

Aust Dent J, 62: 186-191, 2017.
10.Tadokoro O, Ando H, Kawahara I, Asanuma N, Okumura M, Kitagawa J, Kondo
E, Yagasaki H: Distribution and origin of VIP-, SP-, and phospholipase
Cβ2-immunoreactive nerves in the tongue of the bullfrog, Ranacatesbeiana. Anat Rec (Hoboken), 299: 929-942, 2016.
11.Zakir HM, Kitagawa J, Fathilah AR, Bakri MM: Muscle Spindles Provide
Servo-assistance to Jaw-closing Muscles for Chewing Hard Foods. Sains
Malaysiana, 44:593-597, 2015.
12.Takatsuji H, Takahashi K, Kitagawa J: Physiological and pharmacologicalactions involved in the pharyngeal and laryngeal sensation. Nihon
Yakurigaku Zasshi, 145: 278-282, 2015.
13.Mostafeezur RM, Shinoda M, Unno S, Zakir HM, Takatsuji H, Takahashi K,Yamada Y, Yamamura K, Iwata K, Kitagawa J: Involvement of astroglial
glutamate-glutamine shuttle in modulation of the jaw-opening reflex
following infraorbital nerve injury. Eur J Neurosci, 39: 2050-2059,2014.
14.Takahashi K, Shingai T, Saito I, Yamamura K, Yamada Y, Kitagawa J:
Facilitation of the swallowing reflex with bilateral afferent input fromthe superior laryngeal nerve. Neurosci Lett, 562: 50-53, 2014.
15.Takeda M, Takahashi M, Kitagawa J, Kanazawa T, Nasu M, Matsumoto S:
Brain-derived neurotrophic factor enhances the excitability ofsmall-diameter trigeminal ganglion neurons projecting to the trigeminal
nucleus interpolaris/caudalis transition zone following massetermuscle inflammation. Mol Pain, 9: 49 (online journal), 2013.
16.Mostafeezur RM, Zakir HM, Takatsuji H, Yamada Y, Yamamura K, Kitagawa
J: Cannabinoids facilitate the swallowing reflex elicited by thesuperior laryngeal nerve stimulation in rats. PloS ONE, 7(11):e50703(online journal), 2012.
17.Zakir HM, Mostafeezur RM, Suzuki A, Suzuro Hitomi S, Suzuki I, Maeda
T, Seo K, Yamada Y, Yamamura K, Lev S, Binshtok AM, Iwata K, Kitagawa
J: Expression of TRPV1 channels after nerve injury provides an essential
delivery tool for neuropathic pain attenuation. PloS ONE, 7(9):e44023(online journal), 2012.
18.Mostafeezur RM, Zakir HM, Yamada Y, Yamamura K, Iwata K, Sessle BJ,Kitagawa J: The effect of minocycline on the masticatory movements
following the inferior alveolar nerve transection in freely moving rats.

Mol Pain, 8: 27 (online journal), 2012.
19.Takatsuji H, Zakir HM, Mostafeezur RM, Saito I, Yamada Y, Yamamura K,Kitagawa J: Induction of the swallowing reflex by electrical stimulationof the posterior oropharyngeal region in awake humans. Dysphagia, 27:
473-480, 2012.
20.Takeda M, Tsuboi Y, Kitagawa J, Nakagawa K, Iwata K, Matsumoto S:Potassium channels as a potential therapeutic target for trigeminal
neuropathic and inflammatory pain. Mol Pain, 7: 5 (online journal),
2011.
21.Matsumoto S, Yoshida S, Ikeda M, Kadoi J, Takahashi M, Tanimoto T,Kitagawa J, Saiki C, Takeda M, Shima Y: Effect of acetazolamide ontransient K+ currents and action potentials in nodose ganglion neuro
ｎs of adult rats. CNS Neurosci Ther, 17: 66-79, 2011.
22.Iwata K, Miyachi S, Imanishi M, Tsuboi Y, Kitagawa J, Teramoto K, Hitomi
S, Shinoda M, Kondo M, Takada M: Ascending multisynaptic pathways fromthe trigeminal ganglion to the anterior cingulate cortex. Exp Neurol,
227: 69-78, 2011.
23.Yamamura K, Kitagawa J, Kurose M, Sugino S, Takatsuji H, Mostafeezur
RM, Zakir HM, Yamada Y: Neural mechanisms of swallowing and effects oftaste and other stimuli on swallow initiation. Biol Pharm Bull, 33:1786-1790, 2010.
24.Zakir HM, Kitagawa J, Yamada Y, Kurose M, Mostafeezur RM, Yamamura K:
Modulation of spindle discharge from jaw-closing muscles during chewing
foods of different hardness in awake rabbits. Brain Res Bull, 83: 380-386,2010.
25.Nakagawa K, Takeda M, Tsuboi Y, Kondo M, Kitagawa J, Matsumoto S,Kobayashi A, Sessle BJ, Shinoda M, Iwata K: Alteration of primaryafferent activity following inferior alveolar nerve transection in rats.
Mol Pain, 6: 9 (online journal), 2010.
26.Takeda M, Kitagawa J, Nasu M, Takahashi M, Iwata K, Matsumoto S: Glial
cell line-derived neurotrophic factor acutely modulates theexcitability of rat small-diameter trigeminal ganglion neurons
innervating facial skin. Brain Behav Immun, 24: 72-82, 2010.
27.Okada-Ogawa A, Suzuki I, Sessle BJ, Chiang CY, Salter MW, Dostrovsky
JO, Tsuboi Y, Kondo M, Kitagawa J, Kobayashi A, Noma N, Imamaura Y, Iwata
K: Astroglia in medullary dorsal horn (trigeminal spinal subnucleuscaudalis) are involved in trigeminal neuropathic pain mechanisms. JNeurosci, 29: 11161-11171, 2009.
28.Kitagawa J, Nakagawa K, Hasegawa M, Iwakami T, Shingai T, Yamada Y, Iwata
K: Facilitation of reflex swallowing from the pharynx and larynx. J Oral
Sci, 51: 167-171, 2009.
29.Shoda E, Kitagawa J, Suzuki I, Nitta-Kubota I, Miyamoto M, Tsuboi Y,Kondo M, Masuda Y, Oi Y, Ren K, Iwata K: Increased Phosphorylation ofextracellular signal-regulated kinase in trigeminal nociceptive
neurons following propofol administration in rats. J Pain, 10: 573-585,
2009.
30.Tsujimura T, Kondo M, Kitagawa J, Tsuboi Y, Saito K, Tohara H, Ueda K,Sessle BJ, Iwata K: Involvement of ERK phosphorylation in brainstem
neurons in modulation of swallowing reflex in rats. J Physiol, 587:805-817, 2009.
31.Tsujimura T, Kitagawa J, Ueda K, Iwata K: Inhibition of swallowing reflex
following phosphorylation of extracellular signal-regulated kinase innucleus tractus solitarii neurons in rats with masseter muscle
nociception. Neurosci Lett, 450: 361-364, 2009.
32.Honda K, Kitagawa J, Sessle BJ, Kondo M, Tsuboi Y, Yonehara Y, Iwata
K: Mechanisms involved in an increment of multimodal excitability of
medullary and upper cervical dorsal horn neurons following cutaneous
capsaicin treatment. Mol Pain, 4: 59 (online journal), 2008.
33.Kitagawa J, Nasu M, Okumura H, Shibata A, Makino M, Terada H, Matsumoto
S: Allopurinol gel mitigates radiation-induced mucositis and dermatitis.
J Radiat Res, 49: 49-54, 2008.
34.Suzuki I, Kitagawa J, Noma N, Tsuboi Y, Kondo M, Honda K, Kanda K,Hasegawa M, Saito K, Okamoto R, Iwata K: Attenuation of naloxone-induced
Vc pERK hyper-expression following capsaicin stimulation of the facein aged rat. Neurosci Lett, 442: 39-43, 2008.
35.Takeda M, Kitagawa J, Takahashi M, Matsumoto S: Activation ofInterleukin-1<beta> receptor suppresses the voltage-gated potassium
currents in the small-diameter trigeminal ganglion neurons following
peripheral inflammation. Pain, 139: 594-602, 2008.
36.Kamo H, Honda K, Kitagawa J, Tsuboi Y, Kondo M, Taira M, Yamashita A,
Katsuyama N, Masuda Y, Kato T, Iwata K: Topical capsaicin application
causes cold hypersensitivity in awake monkeys. J Oral Sci, 50: 175-179,

2008.
37.Matsumoto S, Kitagawa J, Takeda M: The effects of ouabain on restingmembrane potential and hyperpolarization-activated current in neonatal
rat nodose ganglion neurons. Neurosci Lett, 439: 241-244, 2008.
38.Saito K, Hitomi S, Suzuki I, Masuda Y, Kitagawa J, Tsuboi Y, Kondo M,Sessle BJ, Iwata K: Modulation of trigeminal spinal subnucleus caudalis
neuronal activity following regeneration of transected inferior
alveolar nerve in rats. J Neurophysiol, 99: 2251-2263, 2008.
39.Noma N, Tsuboi Y, Kondo M, Matsumoto M, Sessle BJ, Kitagawa J, Saito
K, Iwata K: Organization of pERK-immunoreactive cells in trigeminal
spinal nucleus caudalis and upper cervical cord following capsaicin
injection into oral and craniofacial regions in rats. J Comp Neurol,
507: 1428-1440, 2008.
40.Kitagawa J, Shingai T, Kajii Y, Takahashi Y, Taguchi Y, Matsumoto S:
Leptin modulates the response to oleic acid in the pharynx. Neurosci
Lett, 423: 109-112, 2007.
41.Kitagawa J, Takahashi Y, Matsumoto S, Shingai T: Response propertiesof the pharyngeal branch of the glossopharyngeal nerve for umami taste
in mice and rats. Neurosci Lett, 417: 42-45, 2007.
42.Yoshida S, Takahashi M, Kadoi J, Kitagawa J, Saiki C, Takeda M, Matsumoto
S: The functional difference between transient and sustained K+ currentson the action potentials in tetrodotoxin-resistant adult rat trigeminal
ganglion neurons. Brain Res, 1152: 64-74, 2007.
43.Suzuki I, Harada T, Asano M, Tsuboi Y, Kondo M, Kitagawa J, Gionhaku
N, Kusama T, Iwata K: Phosphorylation of ERK in the trigeminal spinal
nucleus neurons following passive jaw movement in rats with chronic
craniomandibular joint inflammation. J Orofac Pain, 21: 225-231, 2007.
44.Kubota I, Tsuboi Y, Shoda E, Kondo M, Masuda Y, Kitagawa J, Oi Y, Iwata
K: Modulation of neuronal activity in CNS pain pathways following
propofol administration in rats: Fos and EEG analysis. Exp Brain Res,
179: 181-190, 2007.
45.Takeda M, Tanimoto T, Kadoi J, Nasu M, Takahashi M, Kitagawa J, Matsumoto
S: Enhanced excitability of nociceptive trigeminal ganglion neurons bysatellite glial cytokine following peripheral inflammation. Pain, 129:155-166, 2007.
46.Kitagawa J, Takeda M, Suzuki I, Kadoi J, Tsuboi Y, Honda K, Matsumoto

S, Nakagawa H, Tanabe A, Iwata K: Mechanisms involved in modulation oftrigeminal primary afferent activity in rats with peripheralmononeuropathy. Eur J Neurosci, 24: 1976-1986, 2006.
47.Shimizu K, Asano M, Kitagawa J, Ogiso B, Ren K, Kamo H, Iwata K:
Phosphorylation of Extracellular Signal-Regulated Kinase in the
medullary and upper cervical cord neurons following noxious tooth pulp
stimulation. Brain Res, 1072: 99-109, 2006.
48.Kitagawa J, Tsuboi Y, Ogawa A, Ren K, Hitomi S, Saitoh K, Takahashi O,Masuda Y, Harada T, Hanzawa N, Kanda K, Iwata K: Involvement of dorsal
column nucleus neurons in nociceptive transmission in aged rats. J
Neurophysiol, 94: 4178-4187, 2005.
49.Sato T, Kitagawa J, Ren K, Tanaka H, Tanabe A, Watanabe T, Mitsuhashi
Y, Iwata K: Activation of trigeminal intranuclear pathway in rats withtemporomandibular joint inflammation. J Oral Sci, 47: 65-69, 2005.
50.Iwata K, Kamo H, Ogawa A, Tsuboi Y, Noma N, Mitsuhashi Y, Taira M,Koshikawa N, Kitagawa J: Anterior cingulate cortical neuronal activity
during perception of noxious thermal stimuli in monkeys. J Neurophysiol,94: 1980-1991, 2005.
51.Kitagawa J, Kanda K, Sugiura M, Tsuboi Y, Ogawa A, Shimizu K, Koyama
N, Kamo H, Watanabe T, Ren K, Iwata K: Effect of chronic inflammation
on dorsal horn nociceptive neurons in aged rats. J Neurophysiol, 93:3594-3604, 2005.
52.岩田幸一, 北川純一: 覚醒サルを用いた鎮痛効果の評価法. 日本薬理学雑誌, 125: 99-102, 2005.
53.Iwata K, Tsuboi Y, Shima A, Harada T, Ren K, Kanda K, Kitagawa J: Central
neuronal changes after nerve injury: neuroplastic influences of injury
and aging. J Orofac Pain, 18: 293-298, 2004.
54.Iwata K, Miyachi S, Imanishi M, Nakagawa H, Tsuboi Y, Kitagawa J,Teramoto K, Takada M: Ascending pain-related pathways to the anterior
cingulated cortex: retrograde transneuronal tracing with rabies virus.
Pain Res, 19: 85-90, 2004.
55.岩田幸一, 坪井美行, 北川純一: 三叉神経系異常疼痛発症の神経メカニズ
ム. 日本歯科東洋医学会誌, 23: 61-65, 2004.
56.Tsuboi Y, Takeda M, Tanimoto T, Ikeda M, Matsumoto S, Kitagawa J,Teramoto K, Simizu K, Yamazaki Y, Shima A, Ren K, Iwata K: Alterationof the Second Branch of the Trigeminal Nerve Activity Following Inferior

Alveolar Nerve Transection in Rats. Pain, 111: 323-334, 2004.
57.Nikles SA, Pellinen DS, Kitagawa J, Bradley RM, Kipke DR, Najafi K:
Long term in vitro monitoring of polyimide microprobe electricalproperties. Proc. 25th Annu. Int. IEEE-EMBS Conf., Cancun, Mexico:
3340-3343, 2004.
58.Watanabe U, Shimura T, Sako N, Kitagawa J, Shingai T, Watanabe E, Noda
M, Yamamoto T: A comparison of voluntary salt-intake behavior inNa(x)-gene deficient and wild-type mice with reference to peripheral
taste inputs. Brain Res, 967: 247-256, 2003.
59.Fukushima S, Shingai T, Kitagawa J, Takahashi Y, Taguchi Y, Noda T,Yamada Y: Role of the Pharyngeal Branch of the Vagus Nerve in Laryngeal
Elevation and UES Pressure During Swallowing in Rabbits. Dysphagia, 18:
58-63, 2003.
60.Kajii Y, Shingai T, Kitagawa J, Takahashi Y, Taguchi Y, Noda T, Yamada
Y: Sour taste stimulation facilitates reflex swallowing from the pharynx
and larynx in the rat. Physiol Behav, 77: 321-325, 2002.
61.Kitagawa J, Shingai T, Takahashi Y, Yamada Y: Pharyngeal branch of theglossopharyngeal nerve plays a major role in reflex swallowing from thepharynx. Am J Physiol Regul Integr Comp Physiol, 282: R1342-1347, 2002.
62.梶井友佳, 真貝富夫, 北川純一, 高橋義弘, 田口洋, 山田好秋: ラット上喉頭神経水応答の修飾因子. 日本味と匂学会誌, 8: 559-562, 2001.
63.北川純一, 真貝富夫, 高橋義弘, 山田好秋: 咽喉頭の嚥下誘発神経に関する研究. 日本顎口腔機能学会誌, 7: 47-52, 2001.
64.北川純一, 真貝富夫, 高橋義弘, 山田好秋: マウスとラットにおける舌咽神経咽頭枝のうま味応答性の比較. 日本味と匂学会誌, 7: 535-538, 2000.
65.真貝富夫, 北川純一, 高橋義弘, 山田好秋: ラット咽頭の味覚神経の応答性. 日本味と匂学会誌, 6: 591-594, 1999.
66.真貝富夫, 高橋義弘, 北川純一, 永尾陽子, 伏木亨: ラット舌咽神経咽頭枝の味覚応答性の検討. 日本味と匂学会誌, 5: 471-474, 1998.
67.宮岡洋三, 北川純一, 真貝富夫, 山田好秋: 橋味覚野破壊ラットの味溶液
リッキング様式. 日本味と匂学会誌, 4: 381-384, 1997.

【総説】
1. 高辻華子，高橋功次朗，北川純一：咽頭・喉頭感覚が関与する生理・薬理作用．日薬理誌, 145: 278～282, 2015.
2. 北川純一，高辻華子，高橋功次郎，真貝富夫：のどごしについての生理学的考察．日本味と匂学会誌, 20: 143-149, 2013.
3. 高辻華子，北川純一，真貝富夫：のど越しの味と嚥下．JOHNS，29： 57-60，2013.
4. 武 田 守, 坪井美行, 北川純一, 中川量晴, 岩田幸一, 松本茂二: 三叉神
経領域における神経因性疼痛と炎症性疼痛の治療標的としての電位依存性カリウムチャネル. 日本口腔顔面痛学会雑誌, 4: 35-45, 2011.
5. 山田好秋, 高辻華子, 北川純一, 山村健介: 嚥下誘発と味覚・うま味の関連.
日本味と匂学会誌, 17: 127-132, 2010.
6. 北川純一, 岩田幸一: 加齢に伴う痛覚受容機構の変化. 日本口腔顔面痛学会雑誌, 1: 11-16, 2008.
7. Kitagawa J, Takeda M, Suzuki I, Kadoi J, Tsuboi Y, Matsumoto S, Iwata
K: Modulation of trigeminal primary afferent activity in the rats withchronic constriction nerve injury of the infraorbital nerve. J Oral
Biosci, 50: 45-50, 2008.
8. 北川純一, 岩田幸一: 加齢と痛み. 痛みの神経科学会雑誌, 7: 10-14, 2005.
9. 北川純一, 真貝富夫: 喉越しの美味しさ. 日本味と匂学会誌, 7: 199-202,2000.

【著書】
1. 北川純一, 海野俊平, Mohammad Zakir Hossain, 安藤宏, 増田裕次: 口腔・咽頭・喉頭領域の感覚. 口・鼻・耳の感覚メカニズムと応用技術: S&T 出版:
2018, 3-15.
2. Iwata K, Tsuboi Y, Kondo M, Kitagawa J, Ogawa A, Suzuki I: Neuronalmechanisms of neuropathic pain in the trigeminal system. in Nociceptiveand Neuropathic Pain: Mechanisms and Treatments (edited by Bai-Chuang
Shyu and Chih-Cheng Chien). Research Signpost. 2009, 61-75.
3. 岩田幸一, 本田訓也, 北川純一: 大脳皮質における痛み応答：動物. BRAINMEDICAL, 21 (3): メディカルレビュー社: 2009, 15-21.
4. 岩田幸一, 坪井美行, 北川純一, 高田昌彦: Anterior cingulate cortex と痛覚認知. 神経研究の進歩, 48 (6): 医学書院: 2004, 947-953.
5. Kitagawa J, Shingai T, Takahashi Y, Yamada Y: New evidence for initiationof swallowing from the pharynx. in Neurobiology of Mastication - from

Molecular to Systems Approach (edited by Nakamura Y and Sessle BJ).
Elsevier Science B.V. 1999, 483-486.