GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITY

2012

INDEXGRADUATE SCHOOL OF BIOSTUDIES
Greeting from the Dean of the Graduate School ………………………………

4

Policy ………………………………………………………………………………………

6

Education curriculum and How to enroll …………………………………………

7

Features of Education …………………………………………………………………

9

Outline and Composition of Departments …………………………… 10
DIVISION OF INTEGRATED LIFE SCIENCE ………………………………… 11
Department of Gene Mechanisms ………………………………………………… 12
Laboratory of Chromosome Transmission
Laboratory of Gene Biodynamics
Laboratory of Cell Cycle Regulation
Department of Cell and Developmental Biology ……………………………… 13
Laboratory of Cell Recognition and Pattern Formation
Laboratory of Signal Transduction
Department of Plant Gene and Totipotency …………………………………… 14
Laboratory of Plant Molecular Biology
Laboratory of Molecular and Cellular Biology of Totipotency
Department of Applied Molecular Biology ……………………………………… 15
Laboratory of Biosignals and Response
Laboratory of Applied Molecular Microbiology
Laboratory of Molecular Biology of Bioresponse
Department of Responses to Environmental Signals and Stresses …………… 17
Laboratory of Plant Developmental Biology
Laboratory of Plasma Membrane and Nuclear Signaling
Department of Molecular and Developmental Biology ……………………… 18
Laboratory of Genome MaintenanceLaboratory of Nanobiology
Laboratory of Developmental Neurobiology
Department of Molecular and Cellular Biology ………………………………… 19
Laboratory of Molecular and Cellular Immunology
Laboratory of Mammalian Molecular Biology

DIVISION OF SYSTEMIC LIFE SCIENCE …………………………………… 21
Department of Molecular and System Biology…………………………………… 22
Laboratory of Neuroscience
Laboratory of Bioimaging and Cell Signaling

INDEX
Department of Animal Development and Physiology ………………………… 23
Laboratory of Molecular and Cellular Biology
Laboratory of Immunobiology
Laboratory of Molecular Cell Biology and Development
Department of Signal Transductions ……………………………………………… 26
Laboratory of Molecular Neurobiology
Laboratory of Membrane Biochemistry and Biophysics
Department of Functional Biology ………………………………………………… 27
Laboratory of Functional Biology
Department of Biostudies and Society …………………………………………… 27
Laboratory of Science Communication and Bioethics
Department of Mammalian Regulatory Network ……………………………… 28
Laboratory of Cell Regulation and Molecular Network
Laboratory of Viral Oncology
Laboratory of Cell Division and Differentiation
Laboratory of Genetic Information

Map & Access ……………………………………………………………………… 30
Contact ………………………………………………………………………………… 32

Greeting fromthe Dean of
the Graduate School
Dean: YONEHARA
YONEHARA, Shin
Shin, D
D.Sc.
S

THE BEGINNING OF A NEWERA OF LIFE SCIENCES
In the past, most of the important discoveries in

Biostudies has the purpose of training people capableof supporting the human society in the 21st century,
based on a general understanding of the life sciences.

the field of life sciences were made accidentallyor passively as a result of the diligent efforts of the

The three goals of the graduate school

individual researcher. New frontiers were opened(1) Provide education for pursuing the new biostudies

based on the immediate needs of the individual,

at the world's top level

without the support of a systematic educational

To meet the demands of the industry, college

system. The researchers entered the field of lifeand research institutes, individuals are educated insciences incidentally under the past academic system.

the life sciences and master the techniques for the

Therefore, by getting organized, these life scientists

society needs.

could systematize the previously incidental education
and research and establish a new academic system(2) Train individuals to apply the new life sciences forfor the study of life sciences. This new idea does not

the protection of the global environment and for

conflict with the existing departments and faculties.

human welfare

Accordingly, the Graduate School of Biostudies was

Integrate the knowledge and technology infounded in 1999. The aim is to nurture individuals who

the old fields of science, agriculture, medicine andcan value the future of life and its dignity by attempts

pharmacology, and nurture individuals who can

to constructively integrate and understand humans,

contribute to the human society in the 21st century.

animals, plants and the environment, through studiesof the cells and genes, the constituent units of the(3) Nurture individuals who can understand the vari-living body. In this way, the individual is to be nurtured

ous vital phenomena of the living organisms as anaturally to have respect for human dignity andsystemic function, and pursue these systemic func-

concern for the environment.

tions
Nurture individuals who will be leaders in the

THE GOALS OF THE GRADUATE SCHOOLOF BIOSTUDIES
Those trained in the fields of science, agriculture,
medicine and pharmacology, where the studies in thehuman society to pursue their activities for the welfare and happiness of humans in the 21st century,
where humans will be living in harmony with otherliving beings.

life sciences were pursued in the past, have independently contributed greatly to the current developments

In order to meet the demands of the changing

of our society. However, the new Graduate School ofsociety in the 21st century, which will be impossible

4

GRADUATE SCHOOL OF BIOSTUDIESto cope with in the current research academic sys-

In the Graduate School of Biostudies, individuals

tem for the life sciences, a new research and edu-

are trained to make a healthy and fair judgment

cation system is installed to breakdown the walls

based on the academic background of the staff

that have hindered the research in the life sciences

and their prospects for the future; and, establish ain the past. There are two courses in the Graduate

new system to evaluate the effects of education

School of Biostudies.

from multiple aspects from the past.

(1) The Division of Integrated Life Sciences: cell development, cell growth, genetic information and cell(3) Activation and flexibility of staff in the human relations

cycle regarded as a multicellular system, and the

Research is pursued by each staff member in-

totipotency, the mechanism of signal transduction

dependently to develop a new life science based

and the responses among the cell, living being andon active exchange among the various laborato-

environment.

ries in the graduate school.

(2) The Division of Systemic Life Sciences: neuroscience, animal development and physiology, immunobiology and others.

(4) Use of current post-doctoral system and evaluationof academic activities
Full use should be made of the current system,
to provide the increasing necessary number of

AIMS OF THE GRADUATE SCHOOL OF BIOSTUDIES

instructors per student, for the intensive training to(1) Training of individuals with the most advanced

become life scientists at an international level, forknowledge of the life sciences for the next genera-true development of a new research field.

tion
The graduate student studies a higher level oflife sciences beyond the structures of past life science-related fields at each undergraduate level tounderstand the integrated life sciences. The goal
is to nurture a new type of individual with creativeand innovative abilities to cope with the various
unknown themes to be confronted by human beings in the next generation.

(2) Training to establish self for society

GRADUATE SCHOOLCHOOL OF BIOSTUDIESBIOSTUDIES

5

Policy
Education and admission policy
The field of life sciences is transforming andevolving into an advanced branch of science thatwill build a future for humans. With this global trend
as a backdrop, the Graduate School of Biostudies
was established in 1999 as Japan’s first independent graduate school of biostudies, with the aim ofcreating one of the world’s top research institutions

3. All students are trained to become mature andhighly capable researchers who can collaborate
actively with foreign partners.
4. We offer a variety of educational curriculums including biology, medicine, and related areas.
5. We cultivate students with life ethics and astrong sense of responsibility for the world where
humanity and nature must be harmonized.

and developing human resources who will lead thenext generation in the biostudies field. With a set of

Diploma policy

such basic units of life as "cells," "molecules," and1. In the two-year Master’s program, students must

"genes" as a common language, the Graduate

take 1 credit from essential subjects and at least

School of Biostudies is home to innovative research

9 credits from elective subjects offered by theand educational activities, where concepts aboutschool. In addition, students are required to com-diverse organisms and the environments that com-plete 20 credits of lab experiments and practice.

prise them are integrated to create new values

The degree must be accredited through the ex-concerning the future and respect for life.

amination of a master’s thesis.

In response to diverse, social demands that call

2. In the Master’s program, it is necessary for stu-

for an increasingly sophisticated and complex life

dents to acquire and demonstrate knowledgesciences field, the Graduate School of Biostudies

and capability required for professional re-

strives to develop the following human resources:

searchers in the field.

1) Researchers who explore and discover the ba-

3. In the Doctoral program, students who take thesics of life, pursuing the cutting-edge field of bio-

lectures offered by the school and perform thestudies at the highest level in the world;

research for a Doctoral thesis must be enrolled

2) Researchers and highly skilled engineers whofor 3 years (or less by way of exception). Students

contribute to society at public and private re-must take 1 credit from essential subjects andsearch institutions, endeavoring to protect themore than 1 credit from elective subjects. For

global environment and maintain human health,lab experiments and practices, 8 credits are re-well-being, and happiness; andquired. Doctoral students must submit a Doctoral

3) Educators and highly skilled practitioners who
possess broad knowledge of diverse vital phe-thesis and pass the relevant examinations for the
degree.

nomena of living organisms and who contribute

4. In the Doctoral program, each student must

to society through education, industry, mass me-

demonstrate that he/she has the ability to work

dia, and the public sector.

as an independent researcher for successful

Curriculum organization

5. We expect that students will graduate with acompletion of the program.

1. In Master’s programs, basic knowledge of life
science and research competency are acquired.
2. In Doctoral programs, advanced knowledge
and research competency in life science are
acquired. Moreover, each student is trained to
become a researcher who plays an active roleinternationally as a group leader.

6

GRADUATE SCHOOL OF BIOSTUDIES

shared ethical obligation to advance sciencein the best interests of mankind in harmony withnature.

Education curriculum andHow to enroll
Educational Philosophy
We expect to develop the next generation ofinterdisciplinary leaders in the field of life sciencesby providing the best academic research environment under the supervision of the finest graduate
educators and PhD advisers. We emphasize theimportance of the accomplishment of a researchendeavor as well as academic performance in
lecture, seminar, and laboratory practice. At thesame time, the students are trained to discuss anddebate scientific matters and research outcomes.
Students are also trained to have broad outlook
and flexible thinking in life sciences, and areencouraged to travel to international scientificmeetings.

by the end of September. Thus, applicants can select the starting date of either October 1st or April
1st. At the time of application, prospective students
must identify which laboratory head will direct theirdoctoral research. Applicants can apply for only
one lab. Thus, applicants should contact the labhead and fully discuss potential research activities
and availability before filing the application.
Admission examinations for the Doctoral program consist of: 1) an English written test to evaluate
reading comprehension and writing ability; 2) anoral presentation (in English) of a research projectthat applicants have conducted; 3) a subsequentoral examination to evaluate applicants’ knowledge of their field, research competency, logicalthinking skills, and ability to give presentations.

“Global Frontier in Life Science”

2) Master’s Program in "Global Frontier in Life Science"

The Graduate Schools of Biostudies, Medicine,

Our entrance examination for the Master’sand Pharmaceutical Sciences offer "Global Frontier

program is held in July. The guidelines for admissionin Life Science", a new joint educational program

are posted in April on our web site (http://www.

for Doctoral and Master’s students as part of K.U.

lif.kyoto-u.ac.jp/e/). The academic year starts on

PROFILE (Kyoto University Programs for Future Inter-

October 1st or April 1st for those who cannot ob-

national Leaders: http://www.opir.kyoto-u.ac.jp/ku-

tain a "study visa" by the end of September. Thus,

profile/e/index.html). This program, "Global Frontier

applicants can select the starting date of either

in Life Science", is held entirely in English, including

October 1st or April 1st in the next year. Applicants

the entrance examinations, lectures, experiments,

to the Master’s program can apply for up to two

and discussions.

labs, in which they wish to conduct research. Thus,

International as well as domestic students areapplicants should familiarize themselves with fac-welcome. In particular, the School welcomes thoseulty members’ research interests and contact lab

who show a respect for life and a desire to createhead(s) to fully discuss prospective research activi-

a comprehensive and cutting-edge field beyond

ties and availability before filing the application.

existing disciplinary boundaries in life sciences.

Admission examinations for the Master’s program consist of: 1) a set of written examinations of

1) Doctoral Program in "Global Frontier in Life Science"

English proficiency and knowledge of general sub-

The three graduate schools will hold indepen-

jects in biology; and 2) an oral examination. The set

dent entrance examinations for this program,of written examinations is given to all applicants.

and accept up to ten applicants. Our entrance
examination for the Doctoral program is held in
July. The guidelines for admission are posted in
April on our web site (http://www.lif.kyoto-u.ac.jp/e/). The academic year starts on October 1st or
April 1st for those who cannot obtain a "study visa"

GRADUATE SCHOOL OF BIOSTUDIES

7

Lectures held in English for “Global Frontier inLife Science”

credits compulsory)1) Doctoral program

・Common Compulsory subject (1 credit)

Supplied by the Graduate School of Biostudies

・Common Elective subjects and other graduate

・Frontier in Life Science (compulsory subject: 1 credit)
・Advanced English Discussion and Writing in Life
Science I (1 credit)
・Advanced English Discussion and Writing in Life
Science II (1 credit)
Supplied by the Graduate School of Medicine
・Advanced Course in Medical Science (6 credits)
Supplied by the Graduate School of Pharmaceutical
Science・Frontier in Pharmaceutical Science (2 credits)
2) Master’s program
Supplied by the Graduate School of Biostudies
・Beginning Science (compulsory subject: 1 credit)
・Life Science : From Basics to Applications, from
Molecular Biology to Systems Biology (1 credit)
・Global Frontier in Life Science A (2 credits)
・Global Frontier in Life Science B (1 credit)
・Advanced Molecular and Cell Biology I (2 credits)
・Advanced Molecular and Cell Biology II (2 credits)
・Cancer Biology (2 credits)・Basic English Discussion in Life Science I (1 credit)・Basic English Discussion in Life Science II (1 credit)
Supplied by the Graduate School of Medicine
・Medical Science I (2 credits)
・Medical Science II (2 credits)
・Clinical Science Introduction (2 credits)

Requirements for completing programs
1) Requirements for completing the Doctoral program
・"The life-science exercises" (8 credits compulsory)
・Common Compulsory subject (1 credit)
・Common Elective subjects offered by the graduate school and other schools. (at least 1 credit)
For graduation, the student must have enrolled
for at least three years and have completed
at least 10 credits. It is also required to pass theprobation and the examination (thesis defense)
upon completion of a Doctoral thesis written under the supervision of faculty.
2) Requirement for completing the Master’s program
・"The life-science experiments and exercises 1" (10credits compulsory)

8・"The life-science experiments and exercises 2" (10GRADUATE SCHOOL OF BIOSTUDIES

schools’ subjects (at least 9 credits)
For graduation, the student must have enrolled
for at least two years and have completed at least
30 credits. It is also required to pass the probation
and an examination upon completion of the Master’s thesis written under the supervision of faculty.

Features of Education
Features of Education

3) Workshops organized by students

From 2006 to 2007, we conducted the "Biostud-Students in the life science field tend to stay

ies Career-Development Program"supported byin their labs because they are busy working at the

the Ministry of Education, Culture, Sports, Sciencebench. However, it is highly important to commu-

and Technology. From 2008, we have launchednicate with other students studying life science in-the "Program for Developing Pharmaceuticalside and outside of our school during the course ofStrategists"as one of the projects of "Reforming

education. We encourage and financially support

Programs in Education"at Kyoto University. This pro-the students to organize and conduct workshops

gram, in cooperation with the Graduate Schoolby themselves.

of Pharmaceutical Sciences, is aimed to reformthe educational system of graduate schools in our4) Guidance by multiple supervisors

university. Launched in 2011, we are conducting

Heretofore, students who were assigned toa new program named "Global Frontier in Life Sci-

their laboratories studied under the supervision ofence". We are hoping that our students will under-

one faculty member. However, it would be highly

stand the essential aspects of the programs andstimulating for the students if they could havecooperate with us in achieving their goals.

opportunities to discuss their research and othermatters with other faculty members. In our school,

Outline of Reforming Programs in Education
1) Lectures
In master’s programs, the curriculum is designed
to make the students systematically understand life

each student is strongly encouraged to consult
with two additional supervisors for his/her current
research and also career objectives. We hope thatthe practice widens their vision on life science andon their future plans.

science and its related fields. We offer an inherent
lecture for understanding, revealing, and cultivating
the relationship between life science and our society. In our doctoral program, advanced courses inlife science are offered in addition to the seminars
at the lab where each student belongs. This program has been ongoing since 2006.
2) Emphasis on communicative English for life science, with support for attendance at international scientific meetings
It is now very important to give seminars in
English, especially scientific presentations at international meetings. Historically however, the graduate schools in our country scarcely cared about5) Global 30 (http://www.mext.go.jp/english/news/
1283454.htm)
The Ministry of Education, Culture, Sports, Science and Technology has launched the "Global
30" Project for Establishing Core Universities forInternationalization, for the purpose of selecting
universities that will function as core schools forreceiving and educating international students. In
2009, thirteen universities including Kyoto University
were selected. These core universities are playing amajor role in dramatically boosting the number ofinternational students educated in Japan as wellas Japanese students studying abroad.

the development of English communication skills
for students. Our school has been emphasizing thedevelopment of communication skills in English. We
encourage and financially support our students togive talks at international conferences abroad. We
also give them advice for their presentation skills.

GRADUATE SCHOOL OF BIOSTUDIES

9

Outline and Composition of Departments
Research Laboratories in the Graduate School of Biostudies
We contribute for the improvement of future welfare and happiness of humankind

DIVISION OF
INTEGRATED LIFE SCIENCEDIVISION OF
SYSTEMIC LIFE SCIENCE❖ Genetical mechanism

body
dy w
work
orrk
❖ How the brain and the bod

・Department of Gene Mechanisms

y is built❖ How the body・Department of Molecular and Cellular Biology

e hum
human
man disdiseases
seases occur❖ How thent of Mole
ecular and Sy
ystem Biol
ology
ol
l y
Molecular
SystemBiology・Department❖ How multicellular organisms work・Department of Cell and Developmental Biology
・Department of Plant Gene and Totipotency
・Department of Molecular and Developmental
Biologyginteract with❖ How organisms
environments

mal Developm
ma
ment
ent anden
AnimalDevelopment
・Department of Anima
Physiology
nsduuct
c ionsTransductions
・Department of Signal Trannctionall Bi
Biologgy
Biology・Department of Functional
malian Re
R
egu
gula
ulaatot ry Netw
Regulatory
Network・Department of Mammalianon❖ Communications・Bioethis
・Department of Biostudies and Society

・Department of Applied Molecular Biology
・Department of Responses to Environmental
Signals and Stresses

Living organisms

Human beings

Genes and cells

10Outline and Composition of Departments

DIVISION OF INTEGRATED LIFE SCIENCEThis division consists of 17 laboratories including five cooperativelaboratories one from Radiation Biology Center, two from Institute for Virus Research, and two from Institute of Integrated Cell-Material Sciences(iCeMS). Thirty-seven graduate students are accepted in the Master's
Program annually, and 17 in the Doctoral Program. In this division, education and research are focused on the elucidation of basic mechanisms
regulating the chromosome transmission, chromosome replication, RNAarchitecture, cell cycle, cellular transport, cell polarity, signal transduction, growth and development, developmental plasticity, bioconversion,and environmental adaptation. Experimental approaches are taken withmicroorganisms, plants, and animals. We pursue education and research
to elucidate the molecular aspects of Integrative Life Science.

Division of Integrated
Life Science
Department of Gene Mechanisms
D

Laboratory of Chromosome Transmission

Laboratory of Gene Biodynamics■ Associate Professor■ Professor■ Associate Professor■ Assistant Professor

NAKASEKO, Yukinobu■ Main theme

INOUE, Tan
SHIRAISHI, Hideaki
FUJITA, Yoshihiko■ Main theme

Main theme in this laboratory is the analysis of

Research in this laboratory focuses on Synthetic

eukaryotic cell cycle regulation. Especially, regulation

Biology of RNA and RNP (RNA-protein complex).

of chromosome separation and segregation during

Topics of interest include design and development

mitosis has been extensively studied. Fission yeastof new functional RNAs (RNPs), and RNAs (RNPs)-

Schizosaccharomyces pombe is used as a model

based synthetic genetic networks. The design andsystem. This yeast has all basic features involved indevelopment is performed based on the structure ofcell cycle regulation which are conserved among all

naturally occurring RNA molecules and also in vitro

eukaryotic cells. And wide variety of approach canand in vivo evolution technique.

be taken for analysis such as genetical, biochemical,

Also used for research in this laboratory is an edible

molecular biological technique. Identification offilamentous cyanobacterium, Arthrospira platensis,

individual genes involved in regulation of the celland a multicellular green alga, Volvox carteri. By

cycle is start point. Elucidation of whole net work ofusing these organisms, we are investigating growth,

the function of these genes is one of a goal in thisdevelopment and evolution of photosynthetic

research.

microorganisms.

http://kuchem.kyoto-u.ac.jp/seika/

12

DIVISION OF INTEGRATED LIFE SCIENCEDepartment of Celland Developmental Biology

Laboratory of Cell Cycle Regulation

Laboratory of Cell Recognition and
Pattern Formation■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

ISHIKAWA, Fuyuki
NABETANI, Akira
TARUMOTO, Yusuke■ Main theme

UEMURA, Tadashi
CHISAKA, Osamu
USUI, Tadao■ Main theme

Our research activity focuses on the molecular

We are investigating mechanisms that control

mechanism of the flow of genetic infor mation.

epithelial cell polarization and pattern formation of

Chromosomes, the vehicle of genetic materials,

neuronal dendrites and axons during development.

show both faithful and flexible behaviors, in different

The research subjects include: 1) To explore thetime scales, from a single round of the cell cycle tomolecular basis of development, regeneration, andthe evolution of species, and in different conditions,

life-long maintenance of neuronal dendritic trees. 2)

such as development, aging and cancer. TheseTo elucidate how cell-to-cell recognition contributes

apparently opposite behaviors of chromosomes canto planar cell polarity (PCP). 3) To reveal mechanisms

be explained by the need of genetic materials to beof controling cell migration in vertebrate embryos.

transmitted robustly. We are particularly interested

To conduct these studies, we employ a variety ofin how functional domains of chromosome, such as

molecular, cellular, genetic, and computationaltelomeres, are established and maintained, and how

approaches, and use Drosophila, vertebrates, andchromosomes respond to external stimuli, as exemplified

cell lines. Our long-term goal is to shed light onby the genetic instability found in cancer cells. We arepathogenesis of human diseases that are caused bytrying to understand these questions by experimental

defects in the epithelial or neuronal morphogenesis

approaches based on genetics, biochemistry, andand integrity.

molecular and cellular biology in various model systems,
such as fission yeast, Xenopus, and mammalian cells.
1) Closed

2) Semi-open

TelomeraseP3) Open

DNA damage
response

Telomeres consist of DNA ends and the shelterin protein
complex.
1) Long telomeres form a closed state competent toprotect telomere ends. 2) Moderately short telomeres
recruit telomerase to elongate telomere DNA. 3) Very short
telomeres are deprotected, activating the DNA damage
response. Phosphorylation of the shelterin protein regulatethese processes. Yamazaki et al. Genes & Dev. 26:241 (2012)
http://www.lif.kyoto-u.ac.jp/labs/fish/

http://www.lif.kyoto-u.ac.jp/labs/cellpattern/

DIVISION OF INTEGRATED LIFE SCIENCE

13

Division of Integrated
Life Science
Department of Plant Gene and Totipotency

Laboratory of Signal Transduction

Laboratory of Plant Molecular Biology■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

NISHIDA, Eisuke
MIYATA, Yoshihiko
KUSAKABE, Morioh■ Main theme

KOHCHI, Takayuki
NISHIHAMA, Ryuichi
ISHIZAKI, Kimitsune■ Main theme

We are interested in identifying and elucidating

Research in this laboratory focuses on the adaptive

molecular mechanisms that regulate cell

regulation of growth and development to environmental

proliferation, cell differentiation, cell cycle, aging

conditions using model photosynthetic organisms.

and developmental processes. The current topics

Topics include mechanism of photomorphogenesis

include 1) regulatory mechanisms and functions ofand meristem development. We study molecular

the MAP kinase cascade pathways, 2) identification

mechanisms of light sensing by photoreceptors andof novel signal transduction mechanisms, 3) molecular

downstream genetic network of signal transduction.

mechanisms for life span regulation, 4) roles of protein

Approaches by molecular genetics and comparative

kinases in cell cycle progression and regulation, 5)

genomics are taken with Arabidopsis and liverwort

growth factor signaling mechanisms in developmental(Marchantia polymorpha). In particular, the genetic

processes, 6) regulatory mechanisms for mammaliananalysis of Marchantia is unique and efficient as its

circadian clock.

phylogenetically basal position in land plant evolution,
haploid-dominant life cycle, and simple transgenesis.
Genome analysis of Marchantia is also conducted in thislaboratory.

http://www.lif.kyoto-u.ac.jp/labs/signal/

14

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/plantmb/

Department of Applied Molecular Biology

Laboratory of Molecular andCellular Biology of Totipotency

Laboratory of Biosignals and Response■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

SATO, Fumihiko
ENDO, Tsuyoshi
IFUKU, Kentaro■ Main theme

NAGAO, Masaya
KAMBE, Taiho
MIYAMAE, Yusaku■ Main theme

Molecular and cellular biological studies on

Bio-prospecting, a research strategy searching

totipotency in plant cells have been carried out in thisfor compounds that possess beneficial activity forlaboratory using in vitro cultured cells and transgenic

health from natural sources, is one of the projects inplants. Especially, cell/organ differentiation fromthis laboratory. Especially, at present, compounds thatundifferentiated cells, functional differentiations, e.g.

prevent hepatic fibrosis and replication of hepatitis C

oxygen evolving complex in photosystem II, cyclic

virus are the main targets of our bio-prospecting.

electron transfer and gene regulation in chloroplast,

We are also studying how organisms perceive

as well as molecular biology of secondary metabolism,

environmental signals and transduce these signals intosuch as biosynthesis of isoquinoline alkaloids in plantchanges in gene expression, focusing mainly on thecells have been investigated to understand themolecular and cellular basis of zinc metabolism (suchtotipotent functions in plant cells. Development

as uptake, storage, delivery, and maintenance ofof novel genetic engineering techniques such as

metal concentration in cells) in mammal.

differential RNAi, metabolic engineering and synthetic
biology of secondary metabolism for industrial
application have been also investigated.

Stimulation of lipid accumulation by plant extracts

Zinc transporters in mammals
ENTEROCYTE
ZnT4

Zn2+

ZIP4

GENERIC CELL

ZnT1

Zn2+

ZIP5

2+

Zn

ZnT1

Zn2+

ZnT2, 4

ZIP1~3, 6, 8, 10, 14

Zn

Endosomes/Lysosomes

2+

Zn2 +

ZIP7, 9, 13
MTF-1
ZnT1

Zn

ER/
Golgi

ZnT4~7
TGN

MT

2+

ZIP5

Mt-I/II, Znt1 etc

ACINAR CELL
Glutamate vesicles

2+

Zn

ZIP3
ZnT2, 4MAMMARY EPITHELIAL CELL

http://www.lif.kyoto-u.ac.jp/labs/callus/

ZIP4

ZnT5, 8

ZnT3

Insulin granules

β CELLNEURON

http://nucleus.lif.kyoto-u.ac.jp/labs/seitaijoho/

DIVISION OF INTEGRATED LIFE SCIENCE

15

Division of Integrated
Life Science

Laboratory of Applied Molecular Microbiology

Laboratory of Molecular Biology ofBioresponse■ Professor■ Assistant Professor■ Associate Professor

FUKUZAWA, Hideya
YAMANO,Takashi■ Main theme

MASUDA, Seiji■ Main theme

We are focusing on the molecular bases of biologicalResearch in this laboratory focuses on thefunctions of microorganisms contributing to production

mechanism of RNA maturation in the nucleus

of food, energy and industrial materials, and also to

mediated by a number of proteins and small RNAs.

environmental remediation by photosynthesis. Especially

Messenger RNA is synthesized as pre-mRNA by RNA

we employ a green alga, Chlamydomonas reinhardtii,

polymerase II. Pre-mRNA undergoes the multiple

as a model eukaryotic photosynthetic microorganism

processing and become mature mRNA. Then, mRNA

using its genomic information, mutants, and molecular/

is exported to the cytosol to produce protein. During

biochemical techniques.

these processing, a large number of proteins are

The current projects are

conducted to process each step adequately. At(1) Molecular characterization of the carbon-concentratingpresent, we are focusing on the several projects tomechanism supporting photosynthetic carbon fixation,

understand the maturation and quality control of RNAs

energy production, and cell proliferation,in the nucleus. The main projects are (1) The role of(2) Elucidation of regulatory network systems controlling

TREX complex and the AREX complex, which couples

photosynthesis by sensing environmental factors includingtranscription and export of mRNA, (2) mRNA exportchanges of levels in CO2 concentration and light,

pathway in the mammalian cells and enhancing the(3) Metabolic engineering for production of poly-

protein production by optimizing the packaging andunsaturated fatty acid, polysaccharide, glycoprotein,export of mRNA and (3) the RNA quality control in theglycolipid and hydrocarbon,

nucleus to produce the adequately processed RNAs.

(4) Molecular control and signaling of sexual reproduction
by nutrient starvation.

                    



          

http://www.lif.kyoto-u.ac.jp/labs/molecule/16

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/bunshioutou/

Department of Responses to Environmental Signals and Stresses

Laboratory of Plant Developmental Biology

Laboratory of Plasma Membrane andNuclear Signaling■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

ARAKI, Takashi
ENDO, Motomu
YAMAGUCHI, Ayako■ Main theme

TAKEYASU, Kunio
YOSHIMURA, Shigehiro
KUMETA, Masahiro■ Main theme

We are interested in molecular mechanisms

We are interested in how the cell signaling isunderlying plant’s responses to environment. Plants

regulated by specific molecular elements. By using a

have evolved plastic developmental programs withvariety of techniques in biochemistry, molecular andboth genetic and epigenetic basis to adapt theircell biology, and structural biology, we have been

sessile mode of life to changing environment. Using

investigating the structural and functional relationshipan angiosperm, Arabidopsis thaliana and a liverwort,

between the signaling elements (e.g., membrane

Marchantia polymorpha as model systems, we havereceptors and transcription factors) and their targets

been investigating (1) regulation of growth phase(e.g., specific enzymes and DNA). The current projects

transition (especially, flowering) and aging in response

deal with (1) higher-order architectures of prokaryotic

to environmental and endogenous signals, (2) long-and eukaryotic chromosomes, (2) transcriptional

distance systemic signaling in control of development,

regulation in the context of chromatin structure, (3)(3) tissue-specific roles of circadian clock for optimal

cross-talk between nuclear matrix and chromatin, andenvironmental responses, and (4) origin and evolution(4) molecular mechanism of macromolecular transportof regulatory systems for plastic development.

between cytoplasm and nucleus via nuclear porecomplex. The approaches to these problems include
single-molecule imaging and force measurement
using scanning probe microscopy, as well as generalbiochemistry and molecular biological techniques. This
consolidation should reveal a large part of the overall
picture of regulation of cell signaling in eukaryotes
and prokaryotes.

http://www.lif.kyoto-u.ac.jp/labs/plantdevbio/

http://www.lif.kyoto-u.ac.jp/labs/chrom/

DIVISION OF INTEGRATED LIFE SCIENCE

17

Division of Integrated
Life Science
Department of Molecular and Developmental Biology
D

Laboratory of Genome MaintenanceLaboratory of Nanobiology■ Professor■ Assistant Professor■ Professor

MATSUMOTO, Tomohiro
HABU, Toshiyuki■ Main theme

HARADA, Yoshie■ Main theme

The spindle checkpoint, our major research

We are investigating single-molecule dynamic

subject, is a surveillance mechanism to regulate

processes of DNA-protein interactions in DNA

cellular apparatus for compliance with this rule. It is a

replication, repair and recombination which are theunique negative feedback that converts/amplifies amost essential for cellular metabolism by developing

physical signal sensed by kinetochores (attachment ofnovel single-molecule microscopy. This technology

the spindle and/or tension) and regulates the timing

enables us to perform studies by direct visualizationof the sister chromatid separation. Mad2, a signalof single protein localization and displacement

carrier of this feedback, plays a vital role in the spindle

along single DNA that is mechanically manipulated.

checkpoint. It is specifically localized at unattachedThis requires ultra high precision and sensitivity. In

kinetochores that are the origin of the checkpoint

achieving this goal our understanding of fundamental

signal. Mad2 targets CDC20 and inhibits its activity tobiological functions and the several tens of nm-

promote sister chromatid separation. We study Mad2,

sized "mesoscopic" world is promoted, and ultimately

a central player of the spindle checkpoint, to reveal

attracts attention of a great interdisciplinary nature.

mechanisms, which regulate the activity of Mad2.

http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index.htm

18

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.harada.icems.kyoto-u.ac.jp/en/

Department of Molecular andCellular Biology

Laboratory of Developmental
Neurobiology

Laboratory of Molecular and Cellular
Immunology■ Associate Professor■ Professor■ Associate Professor

KENGAKU, Mineko■ Main theme

FUJITA, Takashi
KATO, Hiroki■ Main theme

Neurons in the mammalian brain are orderly

Virus infections, such as influenza A epidemic andarranged in cortices and nuclei for integration into

Chronic Hepatitis C virus infection are still important

specific neural circuits. During development, neurons

diseases and outbreaks of newly emerging viruses are

directionally migrate from the birthplace to theirserious problems for modern society. Higher animals,

destination within the cortex, and then arborize

including humans, are genetically equipped withwell-patterned dendrites and axons to contact

mechanisms, collectively known as innate immunity,with their specific synaptic counterparts. The major

to counteract viral infections. During the course ofgoal of our research is to clarity the mechanisms ofreplication, many viruses generate double-stranded

cortical lamination and functional wiring of neurons(ds)RNA, which is virtually absent in normal cells andin the brain. We seek to identify the molecularlikely serves as a "foreign molecule" in cells. An RNA

signals regulating neuronal migration and dendrite

helicase, RIG-I, functions as a sensor for viral dsRNA. RIG-I

p a t t e r n i n g . We a l s o a i m t o d e v e l o p i m a g i n g

is composed of three domains : a Caspase recruitment

techniques for real-time observation of molecular anddomain (CARD), a DExD/H helicase domain, and acellular dynamics of neuronal migration and dendrite

C-terminal domain (CTD)(Figure). CTD senses viral dsRNA

patterning to discover novel phenomena and rules in

produced in the cytoplasm, leading to a conformational

neuronal motility in the developing brain.

change. This conformational change releases CARD,
which signals to downstream, resulting in the activation

Molecular Layerof genes including those for type I interferon andPurkinje Cell Layer

enzymes that block viral replication. Bottom: Molecular

Granule Cell Layermodeling of dsRNA recognition by CTD of RIG-I.

White Matter

Granule Cell

The purpose of our project is to clarify themolecular mechanism underlying the antiviral innate
Purkinje Cell
Cerebellar nuclei

immunity regulated by RIG-I, and to develop new
diagnostic and therapeutic tools for viral infections.

http://www.kengaku.icems.kyoto-u.ac.jp/

http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden/

DIVISION OF INTEGRATED LIFE SCIENCE

19

Division of Integrated
Life Science

Laboratory of Mammalian Molecular
Biology■ Associate Professor

TACHIBANA, Makoto■ Main theme
Our principal objective is to understand themolecular mechanism of epigenetic gene regulation
and roles of epigenetics in health and disease. We
also study how germ-lineage cell development inmammals is regulated. To address above questions,
we transgenic and gene-targeting technology.

http://www.virus.kyoto-u.ac.jp/Lab/mousemodel.htm

20

DIVISION OF INTEGRATED LIFE SCIENCEDIVISION OF SYSTEMIC LIFE SCIENCEThis division consists of 13 laboratories including 5 cooperative laboratories from Institute for Virus Research, Graduate School of Medicine,
Osaka Bioscience Institute, and RIKEN Center for Development Biology.
Thirty-eight graduate students are accepted in the Master's Program annually, and 16 in the Doctoral Program. In this division, education andresearch are focused on the elucidation of the fundamentals of molecular and systemic biology, cell biology and immunology. Experimental
approaches are taken with viruses, microorganisms, cultured cells andanimals. We pursue education and research to elucidate the molecular
aspects of Systemic Life Science.

Division of SystemicLife Science
Department of Molecular and System Biology
D

Laboratory of Neuroscience

Laboratory of Bioimaging andCell Signaling■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

WATANABE, Dai
ABE, Kentaro
MATSUI, Ryosuke■ Main theme

MATSUDA, Michiyuki
AOKI, Kazuhiro
IMAJO, Masamichi■ Main theme

Research in this laboratory deals with molecular

We are visualizing the growth signal transduction

mechanisms underlying brain function andcascades in living cells by using biosensors based on

dysfunction. The main theme of research is the study

the principle of Foerster resonance energy transfer

of synaptic mechanisms responsible for memory and(FRET). These FRET videos are processed to extract

learning, motor movement and sensory perception.

parameters that characterize the property of each

The regulation and function of neurotransmitter

signaling molecule. We use these parameters

receptors and ion channels in synaptic transmission

obtained in living cells to build kinetic simulationand integration are extensively studied.

models of growth signal transduction cascades.We
are also developing transgenic mice expressing FRET
biosensors to observe the signaling status in living micewith two-photon excitation microscopes.

http://www.phy.med.kyoto-u.ac.jp/

22

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/Department of Animal Development and Physiology

Laboratory of Molecular andCellular Biology

Laboratory of Immunobiology■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

YONEHARA, Shin
SAKAMAKI, Kazuhiro
LEE, Kyung-Kwon■ Main theme

INABA, Kayo
TAKAHARA, Kazuhiko
IYODA, Tomonori■ Main theme

Apoptosis, or programmed cell death, plays an

Our interest is the induction and control ofimportant role in many biological processes, including

immunity and tolerance. We focus on dendritic cells

embryogenesis, development of immune system,(DCs), which are a primary antigen-presenting cell inmaintenance of tissue homeostasis, and elimination

the immune system. Studies have been conductedof virus-infected and tumor cells. We found cellat three levels: antigen uptake and presentation,

surface Fas antigen (Fas), which can directly mediate

surface molecules and cytokines that mediate cell-

apoptosis-inducing signals into cells by stimulation withcell interactions, and pathways for function in vivo.

agonistic anti-Fas mAbs or Fas ligand (Yonehara S, et

Our current major topics include the development ofal., 1989; Itoh N, et al., 1991). Our main research projectDCs from precursor cells, control of differentiation andis to understand the intracellular signal transduction

maturation of DCs, antigen handling mechanisms,

mechanism of cell death including apoptosis andmigratory characteristics from blood stream throughcaspase-independent novel types of cell death,

peripheral tissues to T area of lymphoid organs, andand the biological significance/physiological role ofactivation of antigen-specific CD4 and CD8 T cells.

cell death and cell death-regulating molecules. In

DCs have been applied clinically in immunotherapy

conjunction with these studies, we have been trying to

as nature's adjuvant to induce and amplify immune

identify other cell death-related molecules that play

responses. For better vaccine design, control of DC

a key role in embryogenesis, tumorigenesis or immune

function using molecular techniques to introduce

system. Investigations of molecular mechanisms andfunctional genes and molecules are also conducted.

physiological roles of cell death and its related molecules
are important for a better understanding of mammalianembryogenesis, tumorigenesis and immune system.

http://www.lif.kyoto-u.ac.jp/labs/Fas/

http://zoo.zool.kyoto-u.ac.jp/imm/

DIVISION OF SYSTEMIC LIFE SCIENCE

23

Division of SystemicLife Science

Laboratory of Molecular Cell Biology andDevelopment（Matsuzaki Laboratory）
MATSUZAKI, Fumio■ Visiting Professor（Imai Laboratory）■ Visiting Associate Professor■ Main theme■ Main theme

IMAI, Takeshi

We seek to explore the molecular mechanisms

Neural circuit formation in vertebrates depends onunderlying the organization of cells into highly ordered

peripheral inputs to a certain extent. We are studying

structures in the developing brain. The vertebrate

how the neural circuits are constructed from peripherybrain comprises a considerably larger number ofto the central nervous system in a hierarchical manner.

neurons arranged in a vastly complex functional

We focus on the mouse olfactory system as a model

network, which develops from a single layer ofsystem. We are particularly interested in how the odorantepithelial cells that function as neural stem cells.

receptor control axonal projection of olfactory sensory

Those cells initially proliferate to expand the stem cell

neurons and how the peripheral inputs instruct specificpopulation. Subsequently neural stem cells undergo

neuronal circuits in the olfactory bulb. We are also trying

asymmetric cell divisions to generate self-renewing

the single-cell transcriptome analyses, in vivo imaging,and differentiating daughter cells. Thus the transitionand novel genetic tools to approach these issues.

from the proliferative phase to the neurogenic
phase is critical for the determination of the brain

Axonal projection of olfactory sensory neurons to
the olfactory bulb.

size. Asymmetric cell division also appears to play anessential role in the neuronal production. However,
little is known about mechanisms controlling thosecritical events in the brain development.
We use both an invertebrate (Drosophila) andvertebrate (mouse) model systems to understandprinciples for the brain organization such as:
1. How the timing of the proliferative to neurogenictransition is determined in the brain development.
2. How neural stem cells simultaneously generate
self-renewing and differentiating cells.
3. H o w c e l l p o l a r i t y c o n t r i b u t e s t o c o n t r o lasymmetric cell division of neural stem cells.
4. How diverse neuronal types are generated froma single neural stem cell over time.
5. How the global brain architecture is dictated by
the structure and activity of neural stem cells

http://imai.uijin.com/english.html
http://www.cdb.riken.jp/en/02_research/0201_core07.html

24

DIVISION OF SYSTEMIC LIFE SCIENCE

（Funabiki Laboratory）■ Visiting Associate Professor

FUNABIKI, Kazuo■ Main theme
We analyze neural circuits related to the reflexive
eye movements in mice. Reflexive eye movements aregood models to study neural mechanisms for motor
control and learning, because the inputs (vestibular,
visual stimuli) are precisely controlled and the outputs(eye movements) are quantitatively measured. In theneural circuits related to reflexive eye movements, we
focus on the cerebellar flocculus and the vestibular
nucleus. We record Purkinje cell response of thecerebellar flocculus in alert mice with simultaneousrecording of eye movements. Recently we developed
a fluorescence micro-endoscope which can observe
spatio-temporal pattern of neural activities in vivo. We
apply this endoscope for the analysis of cerebellar
granular layers in alert mice to elucidate neuralmechanisms for motor control and learning.

http://www.obi.or.jp/japanese/introduction/set_
systemsbiology.html

DIVISION OF SYSTEMIC LIFE SCIENCE

25

Division of SystemicLife Science
Department of Signal Transductions
D

Laboratory of Molecular Neurobiology

Laboratory of Membrane Biochemistry
and Biophysics■ Professor■ Associate Professor■ Assistant Professor■ Associate Professor■ Assistant Professor

NEGISHI, Manabu
KATOH, Hironori
OINUMA, Izumi■ Main theme
Outline of Teaching Activities

TAKEMATSU, Hiromu
NAITO, Yuko

■ Main theme
Research in this Laboratory focuses on the biological

The laboratory provides seminars which review andfunction of membrane lipids and carbohydrate.

discuss recent progress in molecular mechanisms of

Outline of Research Activities are as follows:

neuronal functions(1) Sphingolipid-mediated signal transduction in
Outline of Research Activities

mammals and yeasts

The main themes of research in this laboratory(2) Pathophysiological study on multinucleated

are the molecular mechanisms underlying neuronalcell formation in brains of patients of Krabbe's

network formation and neuronal signal transductions.
1. Neuronal functions and signal transductions of
GTP-binding proteins
2. Molecular mechanisms for axon guidance
3. Regulatory systems of synaptic transmission
4. Signal transduction of neuronal polarity formationdisease, one of sphingolipid-related disorders.
(3) Molecular biological studies on the sialic acidconverting enzyme and its function using
knockout mice(4) Study on responsible genes for glyco-chain
expression using DNA microarray and corelation analysis

http://www.lif.kyoto-u.ac.jp/labs/negishi/index-e.html

26

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/kozutsumi/Department of Functional Biology

Department of Biostudies and Society

Laboratory of Functional Biology

Laboratory of Science Communication
and Bioethics■ Professor■ Lecturer■ Assistant Professor

KAKIZUKA, Akira
HORI, Seiji
OHIZUMI, Hiroshi■ Main theme■ Main theme

The major experimental themes being analyzed

In our laboratory, we aim to identify essential issues

in our laboratory are the following: (1) The molecularin the interface between biostudies and the society,and biochemical basis of cell deathand to propose possible actions or solutions.

The aim of this research is to understand themolecular mechanisms underlying carcinogenesis andneurodegeneration and to develop new strategies
for the treatment of cancers and neurodegenerative
disorders.

Currently, we are focusing on the following threeareas.
1.Theoretical and practical analysis of science
communication.
In addition to organizing practical activities such(2) The molecular basis of gene expression

as "Genome Square", a public event (http://hiroba.

networks determining energy expenditure and obesity

genome.ad.jp/ in Japanese language only), we

One of the main features of life science researchanalyze the effects and significance of sciencein the coming years will be that the results obtained

communication. This includes the communicationfrom fundamental research should ideally be

between scientists and the general public, and that

directly connected to thegood of society. From thisamong scientists and scientific communities.

standpoint, in addition to handling topics with high

2. Analysis of bioethical issues in biostudies.

scientific significance, we aim to contribute to the

We study ethical, legal and social implications ofdevelopment of treatments for neurodegenerative

biostudies such as human genome research anddiseases and cancers from our research results.
We hold the same view on scientific education,

human stem cell research.
3. Analysis of modern history of biostudies.

and through training individuals to communicate their

We analyze the development and changes ofideas logically yet effectively, as well as by nurturingbiostudies in the last 20 to 30 years through literature

their creativity, in addition to strengthening theirsurveys and interviews with scientists.

practical research skills, we aim to cultivate opinion
leaders standing at the core of life science research inthe 21st century.

http://www.lif.kyoto-u.ac.jp/labs/funcbiol/

DIVISION OF SYSTEMIC LIFE SCIENCE

27

Division of SystemicLife Science
Department of Mammalian Regulatory Network
D

Laboratory of Cell Regulation and
Molecular Network

Laboratory of Viral Oncology■ Professor■ Associate Professor■ Professor■ Associate Professor■ Assistant Professor

SUGITA, Masahiko
MATSUNAGA, Isamu■ Main theme

TOMONAGA, Keizo
HIJIKATA, Makoto
HONDA, Tomoyuki■ Main theme

Full attention of the recently set up Sugita’s

The researches carried out in our laboratory arelaboratory has been directed to a novel lineage

focused on several RNA viruses, including bornavirus,of antigen-presenting molecules, CD1. Unlike

influenza virus and hepatitis C virus. All our projects

conventional MHC molecules that present protein-

aim to understand the fundamental mechanisms ofderived peptide antigens, molecules of thethe replication and pathogenesis of these viruses.

human group 1 CD1 family (CD1a, CD1b, CD1c)

We are investigating the replication and persistent

mediate presentation of lipid antigens to specificmechanism of the bornavirus in the cell nucleus.

T lymphocytes. By taking cell biological and

The understanding the biological significance of theimmunological approaches, this group wishes toendogenous element of bornaviruses in mammalianestablish a molecular and cellular basis for CD1-

genomes is one of the main focuses of bornavirus

dependent immunity and determine how CD1 hasresearches. We also aim to develop a novel RNA virus

been evolved to function critically in host defense.

vector using bornavirus, which can express stably

An important extension of this study is a challenge

functional small RNAs. In Influenza virus researches

for developing a new type of lipid-based vaccines

we examine the response of host cells to the virus

against cancer and microbial infection.

infection. The understanding of the molecularmechanism of tumorgenesis caused by hepatitis
C virus infection is also the main purpose of ourlaboratory.

http://www.virus.kyoto-u.ac.jp/Lab/SugitaLab.html

28

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.virus.kyoto-u.ac.jp/virus/ganvirus.html

Laboratory of Cell Division and
Differentiation

Laboratory of Genetic Information■ Professor■ Assistant Professor■ Assistant Professor■ Professor

TOYOSHIMA, Fumiko
MATSUMURA, Shigeru
MAEKAWA, Momoko■ Main theme

SHIMIZU, Akira■ Main theme

Oriented cell division, which is determined by

Major goal of research in this laboratory is tothe axis of a mitotic spindle, plays an essential role

understand molecular and cellular mechanisms

in morphogenesis, asymmetric cell division and stem

underlying highly systemic functions of living things,

cell self-renewal. There is increasing evidence for thesuch as immune and neural systems. For this purpose,

implication of spindle misorientation in mammalianstructure and regulation of genetic informationdiseases, including tumorigenesis and polycystic

responsible for such systemic functions are being

kidneys. Our group seeks to explore the molecularanalyzed using model animals, for example,

mechanisms underlying the determination of celltransgenic or gene disrupted mice. Our research isdivision axis in both culture cells and in developing

focused on the following subjects:

mouse embryo. Our research is focused on thefollowing subjects:

1. A n a l y s i s o f m o l e c u l a r m e c h a n i s m s a n dregulation of chromatin modification, gene
expression, gene rearrangements and RNA

1, Mechanisms for the oriented cell division.
2, Cell division and cell differentiation of ES cells
and iPS cells.
3, Oriented cell division in the stratified epitheliumof mouse skin.
4, A role of lipid metabolites in the control of cell
division.
5, Control mechanisms for the membrane traffic
during mitosis.

processing during lymphocyte differentiation.
2. Making and characterization of model miceof immunodeficiency or autoimmune byintroduction of, or targeted disruption ofinterleukin, immunoglobulin or other genes.
3. Analysis of molecular and cellular mechanism for
lymphocyte mobility and formation of immunomicroenvironment during development andimmune reaction.

http://www.virus.kyoto-u.ac.jp/Lab/toyoshima.html

DIVISION OF SYSTEMIC LIFE SCIENCE

29

Map & AccessGetting to Kyoto University

URL: http://www.kyoto-u.ac.jp/en/access/getting/getting_1.htm

RIKEN Center for Developmental Biology▼Laboratory of Moleculer Cell Biology
and Development

KYOTO

Faculty of Medicine Bldg.F □SUITA

Laboratory of Bioimaging and Cell Signaling ▼KOBESouth Campus Research Building for □Integrated Life Sciences / Building G

OSAKA

Osaka Bio Institute▼Laboratory of Moleculer Cell Biology
and Development

Laboratory of Chromosome Transmission ▼Laboratory of Cell Cycle Regulation ▼Laboratory of Cell Recognition and ▼Pattern Formation
Laboratory of Plasma Membrane and ▼Nuclear Signaling
Laboratory of Molecular and Cellular Biology ▼Laboratory of Immunobiology ▼Laboratory of Molecular Neurobiology ▼Graduate School of Biostudies (Oﬃce) ▼to Kokusai kaikan

Kitaoji St.

Science Frontier Laboratory □Higashi-ichijo

Karasuma Imadegawa

Imadegawa St.

Kawaramachi St.

Karasuma St.

Horikawa St.

Radiation Biology Center □Kyoto Imperial Palace

Laboratory of Neuroscience ▼Laboratory of Functional Biology ▼Marutamachi St.

Laboratory of Genome Maintenance ▼Oike St.

Faculty of Pharmaceutical □Sciences Main Bldg.

Gojo St.
Karasuma Line

Shitijo St.

1

Konoe St.

to Osaka

Kawabata St.

Marikoji St.

Higashioji St.

※

Faculty of Medicine Campus /Faculty of Pharmaceutical Science Campus

Shijo St.

Hankyu Ry.

to Osaka

Laboratory of Membrane ▼Biochemistry and Biophysics

Tozai Line

Kyoto Sta.
Kintetu Line

to Nara□ Institute for Virus Research Main Bldg.
▼ Laboratory of Molecular and Cellular Immunology▼ Laboratory of Cell Regulationand Molecular Network▼ Laboratory of Cell Division and Diﬀerentiation□ Molecular Biology Research Bldg.
Faculty of Medicine Center for Genomic Medicine
Kasuga St.

30

Map & Access▼ Laboratory of Mammalian Molecular Biology▼ Laboratory of Viral Oncology▼ Laboratory of Genetic Information※

North Campus Researc Building □for Integrated Life Sciences
Laboratory of Gene Biodynamics ▼Laboratory of Plant Molecular Biology ▼Laboratory of Biosignals and Response ▼Laboratory of Applied ▼Molecular Microbiology
Laboratory of Molecular ▼Biology of Bioresponse
Laboratory of Plant ▼Developmental Biology
Laboratory of Science ▼Communication and Bioethics

Faculty of Agriculture (Main bldg) □Laboratory of Molecular and ▼Cellular Biology of Totipotency

Faculty of Science (Bldg. No.2) □Laboratory of Signal Transduction ▼to Kurama
Eizan Ry.

Ke

ifu

ku

Lin

e.

2

Mt. YoshidaaKonoe St.

Jingu Marutamachi Sta.

Shirakawa
Shi
a St.

Hyakumanben

Kyodai
Seimon-mae

Keihan Line

Kamo River

DemachiYanagi Sta.

St.
egawa

Imad

anben

to Hyakum

2
North Campus

Hyakumanben

3
1

Imadegawa St.

Sanjo Sta.
to Yamashina

Gion Shijo Sta.

Higashioji St.

N

JR Lineto Tokyoto Osaka

Higashi Ichijo St

Main Gate

Higashioji St.

□ Research Bldg. No. 1 / ProgectLab▼ Program - Specific Professor
HEJNA, James Alan

□ Institute for Integrated
Cell - Material Sciences(iCeMs) Complex 2▼ Laboratory of Developmental
Neurobiology▼ Laboratory of Nanobiology

3
Konoe St.

Main Campus

Map & Access

31

Contact
Inquiries concerning entrance examination and"Global Frontier in Life Science"
Telephone number+81-75-753-9222

FAX number+81-75-753-9229

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

E-mail address

gakumu@adm.lif.kyoto-u.ac.jp

URL

http://www.lif.kyoto-u.ac.jp/Global_frontier_in_life_science/index.html

Other inquiries
Administration office at Graduate School of Biostudies
Telephone number+81-75-753-9221

FAX number+81-75-753-9247

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

URL

http://www.lif.kyoto-u.ac.jp/e/