食品生理学研究室業績(2016-2024)■ 原著（Original papers: 26 編） ○：責任著者
1. Watanuki Y, Yajima S, Sashide Y, ○Takeda M, Effect of theanine on the hyperexcitabilityof trigeminal secondary nociceptive neurons following orofacial inflammation in rats.
Eur J Oral Sci, e12961
2. Sashide Y, Toyota R, ○Takeda M "Local administration of the phytochemical, quercetin,attenuates the hyperexcitability of rat nociceptive primary sensory neurons following
inflammation comparable to lidocaine” Journal of Pain 25:755-765
3. Uchino M, Sashide Y, ○Takeda M (2023) Suppression of the Excitability of Rat
Nociceptive Secondary Sensory Neurons following Local Administration of thePhytochemical, (-)-Epigallocatechin-3-gallate. Brain Res 1813:148426
4. Osaki H, Mori M, Ohima K, Shimazu Y, ○Takeda M, (2023) Effect of local administrationof eicotapentaenoic acid on the jaw-opening reflex in rats. Eur J Oral Sci, 131(2) e12917
5. Toyota R, Itou H, Sashide Y, ○Takeda M., (2022) Suppression of the excitability of rat
nociceptive primary sensory neurons following local administration of the phytochemicalquercetin. Journal of Pain 24:540-549
6. Itou H, Toyota R, ○Takeda M., (2022) Phytochemical quercetin alleviates
hyperexcitability of trigeminal nociceptive neurons associated with inflammatory
hyperalgesia comparable to NSAIDs. Mol Pain, 18, 17448069221108971
7. Yamaguchi M, Kinouchi R, Morizumi S, Shmazu Y, ○ Takeda M. (2021) Local
adminisitration of genistein as a local anesthetic agent inhibits the trigeminal nociceptive
neuronal activity in rats. Brain Res Bull 172: 120-128.
8. Hirata K, Nishiki Y, Goto R, Inagaki M, Oshima K, Shimazu-Y, ○Takeda M, (2020)
Resveratrol suppress nociceptive jaw-opening reflex via 5HT3 receptor-mediatedGABAergic inhibition. Neurosci Res 160,25-31,
9. Okubo N, Ishikawa H, Sano R, Shimazu Y, ○Takeda M, (2020) Effect of resveratrol on
the hyperexcitability of nociceptive neurons associated with ectopic hyperalgesia induced
by experimental tooth movement. Eur J Oral Biosci 128:275-283
10. Ikeda A, Muroki A, Suzuki C, Shimazu Y, ○Takeda M, (2020) Resolvin D1 suppress
inflammation-induced hyperexcitability of nociceptive trigeminal neurons associated withmechanical hyperalgesia. Brain Res Bull 154:61-67.
11. Arakawa S, Inoue M, Kinouchi R, Morizumi S, Yamaguchi M, ShimazuY, ○Takeda M.
(2019) Dietary constituents genistein inhibits the hyperexcitability of trigeminal nociceptive
neurons associated with mechanical hyperalgesia following orofacial inflammation.
J Oral Biosci 61:215-220
12. ○Shimazu Y, Kobayashi, Endo S, Takemura J, Takeda M.(2019) Dietary constituent,lutein inhibits acute inflammation-induced c-fos expression of rat trigeminal spinal nucleus
caudalis and C1 dorsal horn neurons. Eur J Oral Sci 127:379-385

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13. Hidaka S, Kanai Y, Takehana S, Syoji Y, Kubota Y, Uotsu N, Yui K, Shimazu Y, ○Takeda
M. （2019） Systemic administration of α-lipoic acid suppresses excitability of nociceptivewide-dynamic range neurons in rat spinal trigeminal nucleus caudalis Neurosci Res144,14-20
14. Syoji Y, Kobayashi R, Miyamura N, Hirohara T, Kubota Y, Uotsu N, Yui K, Shimmazu Y,○Takeda M. (2018) Suppression of hyperexcitability of trigeminal nociceptive neurons
associated with inflammatory hyperalgesia following systemic administration lutein via
inhibition of cyclooxygenase-2 cascade signaling. J Inflamm15:24
15. Nakajima R, Uehara A, Takehana S, Akama Y, Shimazu Y and ○Takeda M (2018)
Decanoic acid attenuates the excitability of nociceptive trigeminal primary and secondary
neuron associated with hypoalgesia. J Pain Res 11:2867-2876
16. Nakazaki S, Tadokoro K, Takehana S, Syoji S, Shimazu Y, ○ Takeda M (2018)
Docosahexaenoic acid attenuates inflammation-induced hyperexcitability of trigeminal
spinal nucleus caudalis neurons associated with hyperalgesia in rats. Eur J Oral Sci 126:458-465
17. Mitome K, Takehana S, Oshima K, Shimazu Y, ○Takeda M (2018) local anesthetic effectof docosahexaenoic acid on the nociceptive jaw-opening reflex in rats. Neurosci Res
137:30-35
18. Kakita K, Tsubouchi H, Adachi M, Takehana S、Shimazu Y, ○Takeda M (2018)
Local subcutaneous injection of chlorogenic acid inhibits the nociceptive trigeminal spinal
nucleus caudalis neurons in rats. Neurosci Res 134:49-55
19. Matsumoto Y, Komatsu K, Takehana S, Syoji Y, Kobayashi A, Shimazu Y, ○Takeda M(2017) Effect of resveratrol on c-fos expression of rat trigeminal spinal nucleus caudalis
and C1 dorsal horn neurons following mustard oil-induced acute inflammation Eur J OralSci 125:338-344.
20. Noguchi Y, Matsuzawa N, Akama Y, Sekiguchi K, Takehana S, Shimazu Y, ○Takeda M(2017) Dietary constituents, decanoic acid suppresses the excitability of nociceptive
trigeminal neuronal activity associated with hypoalgesia via muscarinic M2 receptor
signaling. Mol Pain, 13:1744806917710779
21. Kokuba S, Takehana S, Oshima K, Shimazu Y, ○ Takeda M (2017) Systemicadministration of the dietary constituent resveratrol inhibits the nociceptive ja-openingreflex in rats via the endogenous opioid system. Neurosci Res 119:1-6
22. Takehana S, Kubota Y, Uotsu N, Yui K, Shimazu Y, ○ Takeda M (2017) Acuteintravenous administration of dietary constituent theanine suppress noxious neuronal
synaptic transmission of trigeminal spinal nucleus caudalis in rats. Brain Res Bull 131:7077.
23. Takehana S, Kubota Y, Uotsu N, Yui K, Iwata K, Shimazu Y, ○ Takeda M (2017) The
dietary constituent resveratrol suppresses nociceptive transmission via NMDA receptor.
Mol Pain 13:1744806917697010
24. Shimazu Y, Shibuya E, Takehana S, Sekiguchi K, Oshima K, Kamata H, Karibe H, ○Takeda M (2016) Local administration of resveratrol inhibits excitability of nociceptivewide-dynamic range neurons in rat trigeminal spinal nucleus caudalis. Brain Res Bull
124:262-268.
225. Takehana S, Sekiguchi K, Inoue M, Kubota Y, Ito Y, Yui K, Shimazu Y, ○Takeda M (2016)
Systemic administration of resveratrol suppress the nociceptive neuronal activity of spinal
trigeminal nucleus caudalis in rats. Brain Res Bull 120:117-122.
26. Sekiguchi K, Takehana S, Shibuya E, Matsuzawa N, Hidaka H, Kanai Y, Inoue M, Kubota
Y, Shimazu Y, ○ Takeda M (2016) Resveratrol attenuates inflammation-induced
hyperexcitability of trigeminal spinal nucleus caudalis neurons associated withhyperalgesia in rats. Mol Pain 12:1744806916643082■ 総説 （Reviews: 4 編）
1. ○Takeda M.(2024) Neurophysiological mechanisms underlying the attenuationof nociceptive and pathological pain by phytochemicals: Clinical application as
therapeutic agents．Prog Neurobiol 11:1-13.
2. ○Takeda M and Shimazu Y（2020）Modulatory mechanism underlying how dietary
constituents attenuate orofacial pain. J Oral Sci 62: 140-143
3. ○Takeda M, Takehana S, Sekiguchi K, Kubota Y and Shimazu Y (2016) Modulatory
mechanism of nociceptive neuronal activity by dietary constituents resveratrol.
Int J Mol Sci 17:1702.
4. ○武田 守、竹鼻志織、島津徳人 食品成分による疼痛緩和のメカニズム：レスベラト
ロール、(2017) 日本運動器疼痛学雑誌 9:192-197■ 著書 （3 編）

１．○武田 守、９章；ポリフェノールの疼痛緩和のメカニズムと臨床応用の可能性、ポリフェノールの多角的応用と機能、(監修：田中隆)、2022,シーエムシー出版、pp101-113
２．

○Takeda M, Takehana S, Shimazu Y, The polyphenolic Compound Resveratrol

attenuates Pain :Neurophysiological mechanisms. Polyphenol: mechanisms of actionin Human Health and Disease, Academic Press, 2nd Ed., pp 237-247. Eds. Ronald
Watson Victor Preedy Sherma Zibadi, Academic Press, 2018.
３． ○ Takeda M, Shimazu Y Dietary constituents act as local anesthetic agents:
neurophysiological mechanism of nociceptive pain. Book 2. Chapter 40: TheNeuoscience of Anesthetics and analgesics, 2.4.Novel and non-pharmacologicalaspects and treatments. Pain, Anesthetics and Analgesics. Elsevier, 2021, pp473-485

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