GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITY

2016

INDEXGRADUATE SCHOOL OF BIOSTUDIES
Greeting from the Dean of the Graduate School ………………………………

4

Policy ………………………………………………………………………………………

6

Education curriculum and How to enroll …………………………………………

8

Features of Education ………………………………………………………………… 10

Description of Lectures held in English ………………………………… 11
Outline and Composition of Departments …………………………… 16
DIVISION OF INTEGRATED LIFE SCIENCE ………………………………… 17
Department of Gene Mechanisms ………………………………………………… 18
Laboratory of Chromosome Transmission
Laboratory of Gene Biodynamics
Laboratory of Cell Cycle Regulation
Department of Cell and Developmental Biology ……………………………… 19
Laboratory of Cell Recognition and Pattern Formation
Laboratory of Signal Transduction
Department of Plant Gene and Totipotency …………………………………… 20
Laboratory of Plant Molecular Biology
Laboratory of Molecular and Cellular Biology of Totipotency
Department of Applied Molecular Biology ……………………………………… 21
Laboratory of Biosignals and Response
Laboratory of Applied Molecular Microbiology
Laboratory of Molecular Biology of Bioresponse
Department of Responses to Environmental Signals and Stresses …………… 23
Laboratory of Plant Developmental Biology
Laboratory of Plasma Membrane and Nuclear Signaling
Department of Molecular and Developmental Biology ……………………… 24
Laboratory of Genome MaintenanceLaboratory of Developmental Neurobiology
Department of Molecular and Cellular Biology ………………………………… 25
Laboratory of Molecular and Cellular Immunology
Laboratory of Developmental Dynamics
Laboratory of Ultrastructural Virology

DIVISION OF SYSTEMIC LIFE SCIENCE …………………………………… 27
Department of Molecular and System Biology…………………………………… 28
Laboratory of Single-Molecule Cell Biology
Laboratory of Bioimaging and Cell Signaling

INDEX

Department of Animal Development and Physiology ………………………… 29
Laboratory of Molecular and Cellular Biology
Laboratory of Immunobiology
Laboratory of Molecular Cell Biology and Development
Department of Signal Transductions ……………………………………………… 32
Laboratory of Molecular Neurobiology
Laboratory of Genetics
Department of Functional Biology ………………………………………………… 33
Laboratory of Functional Biology
Department of Biology Education and Heredity ………………………………… 34
Laboratory of Science Communication
Laboratory of Bioeducation
Laboratory of Chromosome Function and InheritanceLaboratory of Science Communication and Bioethics
Department of Mammalian Regulatory Network ……………………………… 36
Laboratory of Cell Regulation and Molecular Network
Laboratory of Viral Oncology
Laboratory of Cell Division and Differentiation
Laboratory of Genetic Information
Laboratory of Bio-functions Biomaterials
Laboratory of Cellular and Molecular Biomechanics
Laboratory of Genome Damage Signaling

Organization ………………………………………………………………………… 41
Map & Access ……………………………………………………………………… 42
Contact ………………………………………………………………………………… 44

Greeting fromthe Dean of
the Graduate School
Dean: ISHIKAWAISHIKAWA, Fuyuki,
Fuyuki MD,
MD PhDESTABLISHMENT AND HISTORY
OF THE GRADUATE SCHOOL OF
BIOSTUDIESThis experience lead us to be selected as one of theschools of the 21ST Century COE Program（21 世 紀 COE
プログラム）in 2002. Furthermore, we were selected as aschool of the “Initiative Project for Attractive Education

Life Science is the study of life in all of its forms andin Graduate School（ 魅 力 あ る 大 学 院 教 育

イニシア

complexity. It encompasses the totality of life forms” and the “Support Program for Education
テ ィ ブ 事 業）

from viruses and bacteria to human beings, and its

Reformation of Graduate School（大学院教育改革支援プ

analyses involve molecules, genes, cells, tissues, living” in 2006 and in 2008, respectively.
ログラム）

organisms, and eco-systems in diverse phases. Life is

We are proud of our educational program. With

not a “molecular machine”. Therefore, it is necessary

support from a variety of projects, we have been diligent

to bring the context of life into the research effort. It

to provide bold and efficient curriculums that reflect therequires using various approaches, various disciplines,

students’ feedback and discussions with teaching staff

and various fields of study. In addition, those who wish

and administrators, who are passionate to improve theto excel in the life sciences must bring to their studies a

graduate education system. We attach particular weightstrong sense of ethics. Biostudies researchers must be

to nurturing students’ autonomous attitudes, allowing

more than manipulators of molecules.

students to develop their own thoughts and originality,

Those trained in specialized disciplines within

to have their own voice and points of view presenting

agriculture, medicine, and pharmacology, where

their own ideas, and to solve problems with innovative

studies in the life sciences were traditionally pursued inapproaches. New discoveries arising from their daily

the past, have independently contributed greatly to

training should be shared at the global level. With thisthe current knowledge base. These accomplishments

goal in mind, a foreign professor, who is a native English

notwithstanding, it is manifestly essential for researchers

speaker and experienced in Life Science research,

to place their work within the whole framework of “Life”

instructs students to improve their discussion, writing, andand to encourage each other as people who love

presentation skills. Students are encouraged to present

life. With such needs and expectations both internally

their research at international meetings, and dissertations

and externally, the Graduate School of Biostudies was

are now accepted in either Japanese or English.

established in 1999, to engage in 21st Century Life
Science as a comprehensive science.

Our research has been frequently cited andis ranked at the forefront of the global scene. Our

It has been 18 years since the school was established.

faculty, who have diverse backgrounds, explore new

In that time, we have accepted numerous students anddirections of research, sharing their own knowledge,

have sent into society graduates who were raised toskills, and ideas with frank discussion in the appropriate

be outstanding researchers through the leadership offorums of the public and research environment. We are

our former deans, Kanji Ohyama, Mitsuhiro Yanagida,

actively collaborating with private/public sectors andKayo Inaba, Eisuke Nishida, and Shin Yonehara.

are attracting competitive external public funding for

Simultaneously, we have published many cutting-edge

research. At the same time, we strongly hope that the

research findings.

fruits of our research will contribute to social happiness.

In 2001, we were selected as an educational base of

Most of our laboratories are located at the Souththe MEXT Center of Excellence Formation Project（COE）.

Campus and the North Campus, improving their research

4

GRADUATE SCHOOL OF BIOSTUDIES

and education in the respective research complexes.

School of Biostudies.

Despite the physical distance between the campuses,(1) The Division of Integrated Life Sciences: cell devel-

the graduate students and teaching/administrative

opment, cell growth, genetic information and cell

staff communicate closely, while upholding the tradition

cycle regarded as a multicellular system, and thethat respects diversity and free-ranging inquiry. This has

totipotency, the mechanism of signal transduction

also engendered a friendly and lively atmosphere toand the responses among the cell, living being andencourage each other.

environment.

All in all, we are pioneering a new Life Science withhope and responsibility. We recognize our responsibility(2) The Division of Systemic Life Sciences: neuroscience,

and are full of hope and confidence that we can reachanimal development and physiology, immunobiol-

our goals. Although we are still a young organization, or

ogy and others.

perhaps because we are a young organization, we will
do our best to bring our school mission and the research

AIMS OF THE GRADUATE SCHOOL OF BIOSTUDIES

fields listed below to fruition. We sincerely appreciate(1) Training of individuals with the most advanced

your further support.

knowledge of the life sciences for the next generation

The three goals of the graduate school(1) Provide education for pursuing the new biostudies at
the world's top level

The graduate student studies a higher level of life
sciences beyond the structures of past life sciencerelated fields at each undergraduate level to un-

To meet the demands of the industry, college,

derstand the integrated life sciences. The goal is toresearch institutes and administrative organizations,nurture a new type of individual with creative andindividuals are educated in the life sciences andinnovative abilities to cope with the various unknown

master the techniques for the society needs.

themes to be confronted by human beings in thenext generation.

(2) Train individuals to apply the new life sciences forthe protection of the global environment and for human welfare(2) Training to establish self for society
In the Graduate School of Biostudies, individuals

Integrate the knowledge and technology inare trained to make a healthy and fair judgment

the old fields of science, agriculture, medicine andbased on the academic background of the staff

pharmacology, and nurture individuals who canand their prospects for the future; and, establish acontribute to the human society in the 21st century.

new system to evaluate the effects of educationfrom multiple aspects from the past.

(3) Nurture individuals who can understand the various
vital phenomena of the living organisms as a systemic function, and pursue these systemic functions(3) Activation and flexibility of staff in the human relations

Nurture individuals who will be leaders in the human

Research is pursued by each staff member inde-society to pursue their activities for the welfare and hap-pendently to develop a new life science based onpiness of humans in the 21st century, where humans will

active exchange among the various laboratories in

be living in harmony with other living beings.

the graduate school.

In order to meet the demands of the changing
society in the 21st century, which will be impossible(4) Use of current post-doctoral system and evaluationof academic activities

to cope with in the current research academic

Full use should be made of the current system, tosystem for the life sciences, a new research andprovide the increasing necessary number of instruc-education system is installed to breakdown the walls

tors per student, for the intensive training to becomethat have hindered the research in the life sciences

life scientists at an international level, for true devel-in the past. There are two courses in the Graduate

opment of a new research field.

GRADUATE SCHOOL OF BIOSTUDIES

5

Policy
Admissions Policy

possess the pioneering spirit to help propel the

Mission and Desired Student Profile

comprehensive and advanced branches of the

As an advanced discipline that holds the key
to the future of humankind, the life sciences arelife sciences into new territory, while appreciating
the dignity of life.

currently undergoing a major evolutionary change.
The Graduate School of Biostudies was inaugu-

Curriculum Policies

rated in 1999 as the first independent school of its

1. The master's program provides a broad educa-kind in Japan with the mission of accelerating thistion spanning all domains of the life sciences,global trend, building a world-class center for re-and cultivates a foundation of competence forsearch, and training the human resources to leadoccupations that demand research abilities andthe life sciences field into the next generation. Ouradvanced expertise in specialized fields.

school has engineered a fusion of cutting-edge

2. The doctoral program endeavors to impartareas in several existing fields and harnessed thecutting-edge specialist knowledge backed bycommon languages of cellular and molecular biol-

diversified academic research, and to cultivate

ogy and genetics that together articulate the prin-independent researchers who can perform wellciples of life. Furthermore, it has developed an inte-

in an international setting. Additionally, it equips

grated understanding of diverse life forms and theadvanced professionals with the knowledge andenvironments they help shape, and has launchedskills required for occupations in specialized fields

innovative efforts in research and education that

as well as the ability to integrate those strengths

will define a new set of values for the future andand assume leading roles.

dignity of life.

3. Students develop the ability to accurately place

To meet the diverse expectations of society

their own research into perspective with theirfor advances in life science, which is becoming in-

specialization, discuss and debate the findings

creasingly sophisticated and complex, the Gradu-

and their significance in an international setting,ate School of Biostudies endeavors to cultivate hu-

and build frameworks for collaboration, as nec-

man resources with the following attributes.

essary.

1. Researchers ready to shed fresh light on, and

4. The curriculum is organized and implemented so

discover, the fundamental principles of life andthat students can apply broad visions to put theirpursue world-class research in new areas of theown research into perspective, build systems oflife sciences

knowledge, and pursue cross-disciplinary study

2. Researchers and advanced engineers commit-

unencumbered by existing fields of specializa-

ted to global environmental conservation andtion. This approach lays the groundwork for thegains in human health, welfare, and well-being,creation of new knowledge with which students

and ready to make social contributions throughwill be ready to tackle unknown fields with a tire-

roles in public and private research institutions

less spirit of innovation.

3. Educators and working professionals with a

5. As they pursue their research at deeper levels,

broad-based understanding of the varied phe-students develop the power to reflect on theirnomena of life in general and ready to makeown research with firm ethical integrity and asocial contributions through roles in education,strong sense of responsibility, and continually in-industry, the news media, and government

quire whether it is consistent with the harmonious

We seek students from a broad spectrum of

coexistence of humanity and nature.

backgrounds who share our values and desire to

6

continue their education through our programs.

Diploma Conferral Policies

We especially welcome students who are both

1. To be eligible for a degree, candidates in theknowledgeable and free of preconceptions, andmaster's program must be: enrolled for a mini-

GRADUATE SCHOOL OF BIOSTUDIES

mum of two years; complete courses offered bytence of humanity and nature.

the School, lab experiments, and practical train-

Doctoral candidates that excel in their re-ing; and attend seminars offered by the labora-

search performance may be deemed eligible for a

tory to which they belong. Candidates need

one-year minimum enrollment requirement insteadto acquire at least one credit hour in requiredof the three-year minimum mandated in item 3

subjects, nine credit hours in elective subjects,

above.

and 20 credit hours in lab experiments, practical training, and seminars. Candidates also must
pass a thesis review and examination administered by the School. To pass the review, the thesis must be logically and consistently written, andmust detail new discoveries or initiatives that willcontribute to insights and advances in the life
sciences.
2. As tangible benchmarks for successful completion of the master's program, candidates will
be expected to demonstrate that they haveacquired a wealth of scholarly knowledge andinsight, research ability in their field of specialization, and the foundation of competence for occupations that demand advanced expertise.
3. Doctoral degree candidates must be enrolled
for a minimum of three years as well as complete
courses offered by the School and seminars offered by the laboratory to which they belong.
Candidates need to acquire at least one credit
hour each in required and elective subjects andeight credit hours in seminars. Candidates also
must be granted research guidance approvaland pass a dissertation review and examination
administered by the School. The doctoral dissertation must be logically and consistently presented, and must detail new discoveries or concepts
that contribute to understandings and advancesin the life sciences.
4. As tangible benchmarks for successful completion of the doctoral program, candidates will be
expected to show that they have acquired theskills and expertise to engage as independent
researchers or lead careers in advanced professional occupations.
5. As another important criterion for consideration
upon completion of their program of study,
doctoral candidates will be evaluated to determine whether they have pursued their researchwith firm ethical integrity and a strong sense of
responsibility, and have confirmed that theirresearch contributes to the harmonious coexis-

GRADUATE SCHOOL OF BIOSTUDIES

7

Education curriculum andHow to enroll
Educational Philosophy
We expect to develop the next generation ofinterdisciplinary leaders in the field of life sciencesby providing the best academic research environment under the supervision of the finest graduate
educators and PhD advisers. We emphasize theimportance of the accomplishment of a researchendeavor as well as academic performance in
lecture, seminar, and laboratory practice. At thesame time, the students are trained to discuss anddebate scientific matters and research outcomes.
Students are also trained to have a broad outlook and flexible thinking in life sciences, and areencouraged to travel to international scientificmeetings.

“Global Frontier in Life Science”
The Graduate Schools of Biostudies and Medi-

October 1st or April 1st in the next year. At the timeof application, prospective students must identify
which laboratory head will direct their doctoral
research. Applicants can apply for only one lab.
Thus, applicants must contact the lab head andf u l l y discuss potential research activities andavailability before filing the application.
Admission examinations for the Doctoral program consist of a documentation screening and anoral examination (interview) to evaluate applicants’knowledge of their field, research competency,
logical thinking skills, and the ability to discuss science in English. Please note that applicants are NOT
required to be physically present in Japan for theexamination.
2) Master’s Program in "Global Frontier in Life Science"
Our entrance examination for the Master’s
program is held in July. The guidelines for admission

cine offer "Global Frontier in Life Science", a joint

are posted on our web site (http://www.lif.kyoto-

educational program for Doctoral and Master’s

u.ac.jp/e/). The academic year starts on Octo-

students as part of K.U. PROFILE (Kyoto University

ber 1st or April 1st. Thus, applicants can select thePrograms for Future International Leaders: http://

starting date of either October 1st or April 1st in the

www.opir.kyoto-u.ac.jp/kuprofile/). This program,next year. Applicants to the Master’s program can"Global Frontier in Life Science", is held entirely inapply for up to two labs in which they wish to con-English, including the entrance examinations, lec-

duct research. Thus, applicants should familiarize

tures, experiments, and discussions.

themselves with faculty members’ research inter-

International as well as domestic students are

ests and must contact lab head(s) to fully discuss

welcome. In particular, the program welcomesprospective research activities and availability

those who show a respect for life and a desire to

before filing the application.

create a comprehensive and cutting-edge field

Admission examinations for the Master’s pro-beyond existing disciplinary boundaries in life sci-gram consist of: 1) a documentation screening

ences.

and 2) an oral examination (interview). Please notethat applicants are NOT required to be physically

1) Doctoral Program in "Global Frontier in Life Science"
The two graduate schools hold independent
entrance examinations for this program, and accept up to ten applicants. Our entrance examination for the Doctoral program is held in July. The
guidelines for admission are posted on our website (http://www.lif.kyoto-u.ac.jp/e/). The academic year starts on October 1st or April 1st. Thus,
applicants can select the starting date of either

8

GRADUATE SCHOOL OF BIOSTUDIES

present in Japan for the examination.

Lectures held in English for “Global Frontier inLife Science”
1) Doctoral program

bation and an examination upon completion of
the Master’s thesis written under the supervision offaculty.

Offered by the Graduate School of Biostudies
・Frontier in Life Science (1 credit : compulsory)
・Advanced English Discussion and Writing in Life
Science I (1 credit)
・Advanced English Discussion and Writing in Life
Science II (1 credit)
・Overseas Research Project 2 (1 credit)
2) Master’s program
Offered by the Graduate School of Biostudies
・Life Science : From Basics to Applications, from
Molecular Biology to Systems Biology (1 credit :compulsory)
・Beginning Science (1 credit)
・Global Frontier in Life Science A (2 credits)
・Global Frontier in Life Science B (1 credit)
・Advanced Molecular and Cell Biology I (2 credits)
・Advanced Molecular and Cell Biology II (2 credits)
・Cancer Biology (2 credits)・Basic English Discussion in Life Science I (1 credit)・Basic English Discussion in Life Science II (1 credit)
・Cellular & Molecular Neuroscience (1 credit)
・Overseas Research Project 1 (1 credit)

Requirements for completing programs
1) Requirements for completing the Doctoral program・" The Life-Science Special Exercises" (8 credits :compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 1 credit)
For graduation, the student must have enrolled
for at least three years and have completed
at least 10 credits. It is also required to pass theprobation and the examination (thesis defense)
upon completion of a Doctoral thesis written under the supervision of faculty.
2) Requirement for completing the Master’s program
・The Life-Science Experiments and Exercises (20credits : compulsory)
・Common Compulsory Subject (1 credit)
・Common Elective Subjects (at least 9 credits)
For graduation, the student must have enrolled
for at least two years and have completed atleast 30 credits. It is also required to pass the pro-GRADUATE SCHOOL OF BIOSTUDIES

9

Features of Education
Features of Education
From 2006 to 2007, we conducted the "Biostudies Career-Development Program" supported by
the Ministry of Education, Culture, Sports, Scienceand Technology. From 2008, we have launched

for students. Our school has been emphasizing thedevelopment of communication skills in English. We
encourage and financially support our students togive talks at international conferences abroad. We
also give them advice for their presentation skills.

the "Program for Developing Pharmaceutical
Strategists" as one of the projects of "Reforming3) Workshops organized by students

Programs in Education" at Kyoto University. This

Students in life science fields tend to stay inprogram, in cooperation with the Graduate School

their labs because they are busy working at theof Pharmaceutical Sciences, is aimed to reformbench. However, it is highly important to commu-

the educational system of graduate schools in

nicate with other students studying life science in-our university. Launched in 2011, we are conduct-side and outside of our school during the course of

ing a new program named "Global Frontier in Life

education. We encourage and financially support

Science". In 2012-2013, we were selected as one

the students to organize and conduct workshopsof the schools of the “MEXT Excellent Graduate

by themselves.

School Hub Formation Project ” and supported ourDoctoral students with the subsidy. We are hop-4) Guidance by multiple supervisors

ing that our students will understand the essential

Heretofore, students who were assigned to

aspects of the programs and cooperate with us in

their laboratories studied under the supervision ofachieving their goals.

one faculty member. However, it would be highly
stimulating for the students if they could have

Outline of Reforming Programs in Education
1) Lectures
In our Master’s program, the curriculum is designed to make the students systematically understand life science and its related fields. We offer abroad range of lectures for understanding, revealing, and cultivating the relationship between life
science and our society. In our Doctoral program,advanced courses in life science are offered in addition to the seminars at the lab where each student
belongs. We gear the program to provide the requisite knowledge and experience for the students'
future careers in various fields of Industry, Government, and Academia, at home and internationally.
2) Emphasis on English communication for life science, with support for attendance at international scientific meetings
It is now very important to give seminars in
English, especially scientific presentations at international meetings. Historically, however, the graduate schools in our country scarcely cared about
the development of English communication skills

10

GRADUATE SCHOOL OF BIOSTUDIES

opportunities to discuss their research and othermatters with other faculty members. In our school,
each student is strongly encouraged to consult
with two additional supervisors for his/her current
research and also career objectives. We hope thatthe practice widens their vision on life science andon their future plans.
5) Global Frontier in Life Science (Program conducted in English)
The Ministry of Education, Culture, Sports, Science and Technology launched the "Global 30"
Project for Establishing Core Universities for Internationalization, for the purpose of selecting universities that will function as core schools for receiving
and educating international students. In 2009,
thirteen universities including Kyoto University wereselected. These core universities are playing a major role in dramatically boosting the number of international students educated in Japan as well asJapanese students studying abroad.

Description of Lectures held in
EnglishMaster’s Program

different research fields in life sciences. Lecturers
are mostly young scientists, who have recently

Beginning Science ...........................................................................................................................................
Lecturers: Uemura, Hejna
Hejna）（Lecturers:

started his or her own researches as lab heads inKyoto University. In addition, the lecturers will pro-This class will cover the history of life science, thevide their experience such as how they have foundbasic phenomena in this field, research meth-enthusiasm in life science research.

odologies, papers that impressed the lecturers
themselves, seminars, and meeting other scientists,

Global Frontier in Life Science B .........................................................................

as the beginning of research. Moreover, rules ofLecturers: Hejna, Chisaka, Toyoshima, Carlton,（Lecturers:

research and proper analysis of data will be dis-

Nishihama）
Nishihamacussed. Furthermore, to broaden students’ views of
their career path, and their future roles as scientists
in the greater context of our society, we would liketo discuss what Professionalism means, in terms ofcommon sense, regardless of particular career objectives, and how to develop systematic and critical thinking skills.

This class will be conducted exclusively in English. The class will meet on Tuesday mornings from10:30-12:00. The format will be a ~60 min lecture,
followed by a ~30 min. student presentation of apaper or papers covering a subject related to thelecture. Depending on the number of students
enrolled, the student presentations may be given
by individual students or pairs of students. There isLife Science:
From Basics to Applications, from Molecular
Biology to Systems Biology...................................................................................................
Lecturers: Hejna, Nagao, Harada, Tabata, Kambe,（Lecturers:
Masuda, Carlton, Yamamoto, Kumeta）
Kumetano limit to the class size; in te past, enrollment has
been about 10 students, which has been conducive to active discussions.
Lectures will cover a wide range of topics, fromplant biology to developmental neurobiology, withThis class will be conducted entirely in English, andattention to methodology and experimental de-

is designed to acquaint students with a broad

sign in student presentations.

range of research areas and methodologies, while
encouraging students to consider the adaptability

Advanced Molecular and Cell BiologyⅠ ..........................

or combination of methods in other systems. Topics

Lecturers: Chisaka, Uemura, Kengaku, Yonehara,（Lecturers:

will range from a quick review of basic molecu-

Kakizuka, Hejna, Kumeta）
Kumetalar biology techniques, to presentations on signaltransduction, transport proteins, applications offluorescence technology, genomewide screening,
single-molecule imaging, systems biology, regenerative medicine, tissue growth and regulation, andRNA research. Discussion is also encouraged. The
class is primarily for first-year Master's students, but
2nd year Master's students may also attend.

This will be a lecture course with a limited numberof students (up to 30). The students will be given
5-8 scientific papers to read. Special emphases will
be on the biologists’ way of thinking as well as thebasic concepts on the gene/protein structure andfunction.
1. Logic and basic concepts in biology : How doesa biologist work and what does a biologist know?
2. Methods in biology : What kinds of technique

Global Frontier in Life Science A........................................................................
Lecturers: Kakizuka, Imamura, Carlton, Kondo
Kondo）（Lecturers:
Lectures in “Global Frontiers in Life Science A” will

does a biologist employ?
3. Specific topics deal with the cell structure andfunction, the nucleus and central dogma

be held in English, and aim to provide basic andfundamental concepts, and knowledge in several

GRADUATE SCHOOL OF BIOSTUDIES

11

*This lecture will be conducted in English.

Advanced Molecular and Cell BiologyⅡ ..........................
Lecturers: Chisaka, Fukuzawa, Fujita, Hejna,（Lecturers:
M. Endo, Kitajima, Kumeta）
KumetaBasic English Discussion in Life ScienceⅠ..........................

This course is an intensive course to introduce theLecturer: Hejna
Hejna）（Lecturer:

underlying cell signaling pathways and their me-

Despite having excellent English reading and writ-

diators covering mammalian cells, plants and mi-

ing skills, most students, even native-English speak-crobes. The final goal of this course aims to provide

ers, need to improve their oral English communica-

an overall knowledge regarding the diversity andtion skills in order to thrive in the new internationalsignificance of cell signaling events in response toscientific community. This class is designed to pro-various stimuli and physiological conditions, andvide students with ample opportunities to practice

the generality among species. The course will bescientific discussions in English, while reviewing ele-

held in combination with related paper discussion.

ments of English grammar and style as they arise.

Students interested in cell and molecular biology

An added benefit will be coverage of a diverseand cell signal transduction are encouraged torange of current scientific topics; students will be-participate.

gin to look critically at scientific data, and how
data are presented. The maximum class size will be

Cancer Biology ...........................................................................................................................................................

8 students, to create a low-stress environment con-

Lecturers: Yoshimura, Ishikawa, Kakizuka, Kumeta
Kumeta）（Lecturers:

ducive to student interactions.

This course is an intermediate-to-advanced course
to study a wide variety of recent topics on cancer

Basic English Discussion in Life ScienceⅡ..........................

biology. Lectures will be given by researchers work-

Lecturer: Hejna
Hejna）（Lecturer:

ing in different fields in Kyoto, Tsukuba, and Na-

This class is designed to build upon existing read-tional Taiwan Universities through a long-distanceing and writing skills by developing strengths in oral

learning system.

presentation and discussion of science in English.

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12

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Aimed at Master's students in particular, who may

Doctoral Program

not yet have extensive research results to present,
the class will consist of shorter (~20-30 min) student
presentations, covering recent science news,

Frontier in Life Sicence.........................................................................................................................
Lecturers: Kageyama and others
others）（Lecturers:

methods, and technology. Students are expected

Prominent leading scientists from several research

to contribute to the class by commenting and rais-

fields of life science, especially those progressing

ing questions, at the same time strengthening theirastonishingly, will provide their research histories

ability to look critically at the way science is pre-from their backgrounds to future prospects, to en-

sented. If time permits, we may also include round-courage young scientists to perform good science.

table discussions.

Cellular & Molecular Neuroscience.......................................................

Advanced English Discussion andWriting in Life ScienceⅠ .................................................................................................................

Lecturers: Hejna and Others
Others）（Lecturers:

Lecturer: Hejna
Hejna）（Lecturer:This is a biennial course and will not be offered inCareer advancement depends upon the ability

2016-2017.

of a researcher not only to read and write English,
but to converse fluently in English. These skills are
crucial for presentations at international meetings, international collaborations, peer review ofmanuscripts, and professional networking.

Thiscourse will allow you to further develop your English
language skills by giving oral presentations. In addition, a homework writing exercise will give youpractice in writing a short document, such as an
abstract, a cover letter, or methods.

Enrollment

will be limited to just 3 students, to allow each student two 60-minute oral presentations, and ample
opportunity for informal discussion in a low-stressenvironment.

Advanced English Discussion andWriting in Life ScienceⅡ .................................................................................................................
Lecturer: Hejna
Hejna）（Lecturer:This class continues the development of presentation and discussion skills in English, as in Advanced
English Discussion and Writing in Life Science I, withthe longterm goal of preparing you for an international scientific career. This course will allow you
to further develop your English language skills bygiving oral presentations. Group discussions will befriendly, but objective.

In addition, a homework

writing exercise will give you practice in writing ashort document, such as an abstract, specific aims,
or methods. Enrollment will be limited to just 3 students, to allow each student two 60-minute oralpresentations, and ample opportunity for informal
discussion in a low-stress environment.

GRADUATE SCHOOL OF BIOSTUDIES

13

Seminars on Gene Mechanism.............................................................................

Seminars on Mammalian Molecular andCellular Biology ..........................................................................................................................................................

This seminar outlines the principle concepts andThis seminar discusses the biological mechanisms of

related research methods and discusses current

regulation in immunity development of the nervous

topics in Gene Biodynamics research. In addition,system and at the molecular, cellular, and organis-

students report and discuss their own research

mal levels.

■ Division of Integrated Life Science

data to improve their research work and presentation skills.

Seminars on Cell and Developmental Biology .
This seminar discusses the themes of Cell and Developmental Biology, Cell Recognition and Pattern Formation, and Cell Signal Transduction, anddeepens understanding of the related areas. In
addition, students report and discuss their own
research data to improve their research work andpresentation skills.

Seminars on Plant Genes and Totipotency.....................
This seminar discusses the latest developments in
Molecular Biology (especially Genome Biology),
Molecular and Cellular Biology, and introduces
research on Cellular Totipotency at the Molecular,
Cellular, and organismal level. In addition, students
have exercises in problem-solving and discussionsof new research.

Seminars on Applied Molecular Biology................................
This seminar explains and discusses the latest issues
regarding environmental response mechanisms in
mammals or microorganisms, and the future direction of research applications.

Seminars on Molecular Mechanisms of
Responses to Environmental Stimuli........................................................
This seminar covers the latest issues regarding various internal and external biological responses, andareas in related fields with different points of view.

Seminars on Molecular and Developmental
Biology .....................................................................................................................................................................................................
This seminar discusses the solved and unsolved
problems about the dynamic behaviors of DNA,
proteins and cellular structures in live cells in orderto deepen the students’ understanding. Students
report their research progress and adjust the direction through discussion.

14

GRADUATE SCHOOL OF BIOSTUDIES

■ Division of Systemic Life Science

immunological disorders, genetic diseases, andSeminars on Molecular and Systems Biology ........

biological mechanisms of adult diseases.

This seminar focuses on how to bridge the gap
between individual molecular activities and patho-

Seminars on Functional Biology...........................................................................

physiological regulation of the dynamic life systems

This seminar explains and discusses the latest in-

by using advanced single-molecule imaging andformation about molecular mechanisms of the

FRET technologies.

homeostatic regulation in physiological and pathological conditions.

Seminars on Animal Development andPhysiology ....................................................................................................................................................................................
This seminar discusses the latest information regard-

Seminars for Department of Biology Educationand Heredity ......................................................................................................................................................................

ing genetic regulation, from a broad perspective.

We will investigate the mechanisms eukaryotic cells

In addition, we cover explains illnesses such asuse to maintain their genomes and to accurately

cancer caused by abnormal cell differentiationtransmit recombined chromosomes to the next

and proliferation, immunological disorders, genetic

generation in the process of sexual reproduction.

disorders, and lifestyle related diseases, outlining

Discussions will focus on developing critical thinking

the research methods used to investigate the mo-skills necessary for science throug presentation andlecular biology and pathogenesis of adult diseases.

critique of research results.

Seminars on Molecular Mechanisms of Signal
Transductions......................................................................................................................................................................

Seminars on Mammalian Regulatory Network ..

Cancer, autoimmune diseases, and life-style relat-

biological cellular control, genetic response, carci-

ed diseases can be caused by genetic abnormali-

nogenesis caused by viruses, the principle of immu-

ties and aberrant response mechanisms. This semi-

nological response; the structure and regulation of

nar explains and discusses dysfunctional biologicalgenetic information responsible for such systemic

mechanisms of cell proliferation, self- / non self-

functions are being analyzed using model animals.

This seminar discusses the mechanisms of systemic

immunological identification mechanisms, cancer,

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15

Outline and Composition of Departments
Research Laboratories in the Graduate School of Biostudies
We contribute for the improvement of future welfare and happiness of humankind

DIVISION OF
INTEGRATED LIFE SCIENCEDIVISION OF
SYSTEMIC LIFE SCIENCE❖ Genetical mechanism❖ How the brain and the body work・Department of Gene Mechanisms❖ How the body is built

log・Department of Molecular and Cellular Biology❖ How the human diseases occur
・Department of Molecular and System Biologyo❖ How multicellular organisms work
olo・Department of Cell and Developmental Biologyy・Department of Plant Gene and Totipotency
enta・Department of Molecular and Developmental
Biologyth❖ How organisms interact withenvironments

・Department of Animal Development andPhysiology
・Department of Signal Transductions
・Department of Functional Biology
ory NetNetwork・Department of Mammalian Regulatory

ethics❖ Communications・Bioethics
tion and Heredity
・Department of Biology Educationy・Department of Applied Molecular Biology
ironmenta
・Department of Responses to Environmental
Signals and Stresses

Living organisms
ms

Human bbeingsGenes and cells

16Outline and Composition of Departments

DIVISION OF INTEGRATED LIFE SCIENCEThis division consists of 19 laboratories including seven cooperativelaboratories from Radiation Biology Center, Institute for Virus Research,and Institute of Integrated Cell-Material Sciences (iCeMS). 40 graduate
students are accepted in the Master’s Program annually, and 19 in the
Doctoral Program. In this division, education and research are focusedon the elucidation of basic mechanisms regulating the chromosometransmission, chromosome replication, RNA architecture, cell cycle, cellular transport, cell polarity, signal transduction, growth and development,
developmental plasticity, bioconversion, and environmental adaptation.
Experimental approaches are taken with microorganisms, plants, andanimals. We pursue education and research to elucidate the molecular
aspects of Integrative Life Science.

Division of Integrated
Life Science
Department of Gene Mechanisms

Laboratory of Chromosome Transmission

Laboratory of Gene Biodynamics■ Associate Professor■ Associate Professor

NAKASEKO, Yukinobu■ Main theme

SHIRAISHI, Hideaki■ Main theme

We are focusing on analyzing the genes involved

We are interested in the mechanism of growth,

in regulation of chromosome function. Especially,

development and evolution of photosynthetic

the genes essential for mitosis have been studied.

microorganisms and currently focusing on the study

Fission yeast Schizosaccharomyces pombe is usedof the edible cyanobacterium Arthrospira (Spirulina)

as a model system. This yeast has all basic featuresplatensis. A. platensis is a filamentous alkalophilic

essential for eukaryotic cell division. Many genes havecyanobacterium that has been traditionally consumed

been identified which regulate the cell cycle of thisas food by people living along the shores of alkaline

yeast. Also, their functions as well as their primarylakes in several regions in the world. Because it can be

structure have been shown to be conserved amongcultured under alkaline conditions where growth of

all eukaryotic cells. We are trying to characterize theseother microalgae is suppressed, it can be produced

genes and their functions by genetical approach.

in mass cultures outdoors as an almost single algal

Elucidation of whole functional network of thesestrain. Because of its easiness of mass culture, it isgenes is one of a goal in our research.

commercially produced in many subtropical areasin the world and consumed worldwide as food, foodadditives, and feed for animals and fishes. We are
currently focusing on developing tools for molecular
genetic studies of this cyanobacterium.

http://kuchem.kyoto-u.ac.jp/seika/

18

DIVISION OF INTEGRATED LIFE SCIENCEDepartment of Celland Developmental Biology

Laboratory of Cell Cycle Regulation

Laboratory of Cell Recognition and
Pattern Formation■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Assistant Professor■ Assistant Professor

ISHIKAWA, Fuyuki
MIYOSHI, Tomoichiro
SADAIE, Mahito■ Main theme
Stable maintenance of genetic information isessential for cell viability. Genetic instability, a conditionin which the genome is not properly maintained, causes
numerous pathologies including cancer and aging.
Telomeres, the ends of chromosomes, play a pivotal
role in this process. We are interested in how telomeresprotect genetic information from intrinsic and extrinsic
insults. Aging can be defined as the accumulationof damaged cells caused by various stresses. Stress isgenerally considered to be non-adaptive. However,
low-dose stress can act in an adaptive role by fosteringcell resistance to prospective lethal stresses. This process
is termed acquired tolerance (or hormesis) and its
molecular mechanisms remain largely unknown. We aretrying to understand how acquired tolerance is induced
molecularly. Arguably, cancer cells in vivo acquire
stress resistance through experiencing ever-lasting
environmental changes. As such, inhibiting the acquired
tolerance in cancer cells may lead to fragility of cancers
to various stresses, including iatrogenic ones.
•Molecular understanding of how telomeresprotect DNA ends in fission yeast and mammals.
•Functional roles of acquired tolerance in various
physiological and pathological conditions.
•Mechanism of retrotransposition and its impact on
genomic instability in the mammalian genome.
•Development of therapeutic strategies forcancer by elucidating the mechanisms of cellularsenescence.
•Mechanism of genomic instability induced bychromosome end-to-end fusions.
In general, cells
exposed to lethal stress
Cell Deathundergo cell death
Lethal Stress(A). However, cells pre(B)conditioned with mild
stress can become
Acquiredresistant to subsequent
Tolerance
lethal stresses (B).
Survival
Mild Stress
Lethal StressThis process is called
Environmental Fluctuationacquired tolerance
or hormesis: an adaptive behavior that is crucial for survival
in an ever-changing environment. In vivo, cancer cells canexperience environmental changes such as hypoxia andiatrogenic stress. This is in contrast to normal cells that live ina stable niche given by the tissue. It is possible that cancer
cells are pre-conditioned by the environmental changes toprepare for the prospective lethal stress. Therefore, inhibitionof this acquired tolerance may make cancer cells sensitive toanti-cancer therapeutics.
http://www.fish.lif.kyoto-u.ac.jp/

UEMURA, Tadashi
USUI, Tadao
HATTORI, Yukako■ Main theme
We are interested in mechanisms that control
animal development and behaviors in response totwo categories of environmental inputs: nutrition andsensory stimuli. Diet is one of critical environmental
determinants that affect developmental time andfitness. We are studying genetic programs for dietary
responses of ecologically distinct Drosophila species
that have different dietary preferences. We arealso focusing on how developing neurons copewith nutritional restriction by using one subclass of
Drosophila somatosensory neurons. By using thesame neuronal subclass, we are dissecting operating
principles of neuronal circuits that evoke selective
behavioral outputs in response to sensory stimuli. To
conduct these studies, we introduce a variety ofmolecular, cellular, omics, imaging, and physiologicalapproaches.

(A)

http://www.cellpattern.lif.kyoto-u.ac.jp/

DIVISION OF INTEGRATED LIFE SCIENCE

19

Division of Integrated
Life Science
Department of Plant Gene and Totipotency

Laboratory of Signal Transduction

Laboratory of Plant Molecular Biology■ Professor■ Lecturer■ Assistant Professor■ Professor■ Lecturer■ Assistant Professor

NISHIDA, Eisuke
KUSAKABE, Morioh
MIYATA, Yoshihiko■ Main theme

KOHCHI, Takayuki
NISHIHAMA, Ryuichi
YAMAOKA, Shohei■ Main theme

We are interested in identifying and elucidating

Research in this laboratory focuses on the adaptive

molecular mechanisms that regulate cell

regulation of growth and development to environmental

proliferation, cell differentiation, cell cycle, aging

conditions using model photosynthetic organisms.

and developmental processes. The current topics

Topics include mechanism of photomorphogenesis

include 1) regulatory mechanisms and functions ofand meristem development. We study molecular

the MAP kinase cascade pathways, 2) identification

mechanisms of light sensing by photoreceptors andof novel signal transduction mechanisms, 3) molecular

downstream genetic network of signal transduction.

mechanisms for life span regulation, 4) roles of protein

Approaches by molecular genetics and comparative

kinases in cell cycle progression and regulation, 5)

genomics are taken with Arabidopsis and liverwort

growth factor signaling mechanisms in developmental(Marchantia polymorpha). In particular, the genetic

processes, 6) regulatory mechanisms for mammaliananalysis of Marchantia is unique and efficient as its

circadian clock.

phylogenetically basal position in land plant evolution,
haploid-dominant life cycle, and simple transgenesis.
Genome analysis of Marchantia is also conducted in thislaboratory.

http://www.signal.lif.kyoto-u.ac.jp/

20

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.plantmb.lif.kyoto-u.ac.jp/

Department of Applied Molecular Biology

Laboratory of Molecular andCellular Biology of Totipotency

Laboratory of Biosignals and Response■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

SATO, Fumihiko
ENDO, Tsuyoshi
IFUKU, Kentaro■ Main theme

NAGAO, Masaya
KAMBE, Taiho
MIYAMAE, Yusaku■ Main theme

Molecular and cellular biological studies on

Bio-prospecting, a research strategy searching for

totipotency in plant cells have been carried out in thiscompounds that possess beneficial activity for healthlaboratory using in vitro cultured cells and transgenic

from natural sources, is one of the projects in thisplants. Especially, cell/organ differentiation fromlaboratory. Especially, compounds that are useful for

undifferentiated cells, functional differentiations,

treatment of lifestyle-related diseases and cancer are

e.g. secondary metabolite production, such as

the main targets of our bio-prospecting.

biosynthesis of isoquinoline alkaloids, oxygen evolving

We are also studying how organisms perceive

complex in photosystem II, cyclic electron transfer

environmental signals and transduce these signals intoand gene regulation in chloroplast, have beenchanges in gene expression, focusing mainly on theinvestigated to understand the totipotent functions inmolecular and cellular basis of zinc metabolism (suchplant cells. Development of novel genetic engineering

as uptake, storage, delivery, and maintenance oftechniques such as genome editing, metabolic

metal concentration in cells) in mammal.

engineering and synthetic biology of secondary
metabolism for industrial application have been also
investigated.

http://www.callus.lif.kyoto-u.ac.jp/

Stimulation of lipid accumulation by plant extracts

http://www.seitaijoho.lif.kyoto-u.ac.jp/

DIVISION OF INTEGRATED LIFE SCIENCE

21

Division of Integrated
Life Science

Laboratory of Applied Molecular Microbiology

Laboratory of Molecular Biology ofBioresponse■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

FUKUZAWA, Hideya
YAMANO, Takashi
KAJIKAWA, Masataka■ Main theme

KATAYAMA, Takane
MASUDA, Seiji
KATOH, Toshihiko■ Main theme

We are focusing on the molecular bases of biological

The aim of our laboratory is to understand thefunctions of microalgae contributing to production of food,

fundamental life processes of microbes and human,

biofuel and industrial materials, and also to environmental

and to develop food- and health-oriented application

remediation by photosynthesis. Especially we employ

research. The research activities mainly include (1)a green alga, Chlamydomonas reinhardtii, as a model

elucidation of the molecular mechanism underlying

eukaryotic photosynthetic microorganism using its genomic

symbiosis and co-evolution between gut microbes

information, mutants, and molecular/biochemicaland host, and (2) elucidation of the mechanism oftechniques.

mRNA processing, export and quality control in the

The current projects are

nucleus in human and its industrial applications.

(1) Molecular characterization of the carbon-concentrating(1) Recent studies have shown that the consortium

mechanism supporting photosynthetic carbon fixation,of gut microbes exerts a considerable influence on

biofuel production, and cell proliferation,

host health. Most researchers approach this topic from

(2) Elucidation of regulatory systems controlling“host” side using a mouse model, but we believe thatphotosynthesis and carbon metabolisms by sensing

approaches from “microbe” side are equally needed

environmental factors including changes of levels in CO2

to understand the symbiosis between them. To thisconcentration, light and nutrient starvation.

end, we are genetically and enzymatically analyzing(3) Metabolic engineering for production of industrial

unique metabolic pathways in gut microbes, which

important fatty acids, glycerolipids and carbohydrates.

should uncover the cross-kingdom communications(4) Molecular control and signaling of sexual reproduction
by nutrient starvation.

between bacteria and host in intestine.
(2) The main projects are (i) the role of TREX and(5) Identification of factors essential for intracellular signal

AREX, which couple transcription and export oftransduction such as calcium and DYRK family ofmRNA, (ii) the molecular mechanism of RNA quality

protein kinases supporting cell survival.

control in the nucleus, (iii) cell engineering for theprotein production using mRNA export mechanism inmammalian cells to apply to industrial applicationsand (iv) identifying the active compounds which
inhibit the mRNA matabolism to apply to medical
care.

http://www.molecule.lif.kyoto-u.ac.jp/

22

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.bunshioutou.lif.kyoto-u.ac.jp/

Department of Responses to Environmental Signals and Stresses

Laboratory of Plant Developmental Biology

Laboratory of Plasma Membrane andNuclear Signaling■ Professor■ Associate Professor■ Associate Professor■ Assistant Professor

ARAKI, Takashi
ENDO, Motomu■ Main theme

YOSHIMURA, Shigehiro
KUMETA, Masahiro■ Main theme

We are interested in molecular mechanisms

Our laboratory studies dynamic properties ofunderlying plant’s responses to environment. Plants

proteins and large protein complexes in cellular

have evolved plastic developmental programs

environments by using a variety of techniqueswith both genetic and epigenetic basis to adapt

in biochemistry, molecular biology and cellular

their sessile mode of life to changing environment.

biology, in combination with nano-technology andUsing an angiosperm, Arabidopsis thaliana andcomputational simulation. Specific research topics

a liverwort, Marchantia polymorpha as model

include:systems, we have been investigating (1) regulation(1) U n d e r s t a n d i n g m o l e c u l a r m e c h a n i s m a n dof growth phase transition (especially, flowering) inbiophysical background of mitotic chromosome

response to environmental signals, (2) long-distancecondensation

systemic signaling in the control of development, (3)(2) S i n g l e - m o l e c u l e i m a g i n g o f h i g h e r - o r d e rtissue-specific roles of circadian clock for optimalarchitectures of DNA, RNA and various

environmental responses, (4) sexual reproduction
processes, and (5) origin and evolution of regulatory
systems for plastic development.

nucleoprotein complexes(3) N o n - i n v a s i v e i m a g i n g o f m e m b r a n e a n dcytoskeletal dynamics by fast-scanning atomic
force microscopy(4) Understanding physical and chemical mechanismsof subunit assembly and disassembly of nuclear
pore complex(5) Structural dynamics of flexible and repetitive
proteins in intracellular environments and molecular
crowding

http://www.chrom.lif.kyoto-u.ac.jp/english/
http://www.plantdevbio.lif.kyoto-u.ac.jp/

index.html

DIVISION OF INTEGRATED LIFE SCIENCE

23

Division of Integrated
Life Science
Department of Molecular and Developmental Biology

Laboratory of Genome MaintenanceLaboratory of Developmental
Neurobiology■ Professor■ Lecturer■ Professor

MATSUMOTO, Tomohiro
FURUYA, Kanji■ Main theme

KENGAKU, Mineko■ Main theme

The spindle checkpoint, our major research

Neurons in the mammalian brain are orderly

subject, is a surveillance mechanism to regulatearranged in cortices and nuclei for integration into

cellular apparatus for compliance with this rule. It is a

specific neural circuits. During development, neurons

unique negative feedback that converts/amplifies a

directionally migrate from the birthplace to their

physical signal sensed by kinetochores (attachment ofdestination within the cortex, and then arborize

the spindle and/or tension) and regulates the timing

well-patterned dendrites and axons to contactof the sister chromatid separation. Mad2, a signal

with their specific synaptic counterparts. The major

carrier of this feedback, plays a vital role in the spindle

goal of our research is to clarity the mechanisms ofcheckpoint. It is specifically localized at unattachedcortical lamination and functional wiring of neurons

kinetochores that are the origin of the checkpointin the brain. We seek to identify the molecularsignal. Mad2 targets CDC20 and inhibits its activity tosignals regulating neuronal migration and dendrite

promote sister chromatid separation. We study Mad2,

p a t t e r n i n g . We a l s o a i m t o d e v e l o p i m a g i n ga central player of the spindle checkpoint, to reveal

techniques for real-time observation of molecular andmechanisms, which regulate the activity of Mad2.

cellular dynamics of neuronal migration and dendrite
patterning to discover novel phenomena and rules inneuronal motility in the developing brain.

Molecular Layer

Purkinje Cell Layer
Granule Cell Layer
White Matter

Granule Cell

Purkinje Cell
Cerebellar nuclei

http://www.rbc.kyoto-u.ac.jp/radiation_system/

24

DIVISION OF INTEGRATED LIFE SCIENCE

http://www.kengaku.icems.kyoto-u.ac.jp/

Department of Molecular and Cellular Biology

Laboratory of Molecular and Cellular
Immunology

Laboratory of Developmental Dynamics■ Professor■ Associate Professor■ Professor■ Associate Professor■ Assistant Professor

FUJITA, Takashi
KATO, Hiroki■ Main theme

KAGEYAMA, Ryoichiro
OHTSUKA, Toshiyuki
KOBAYASHI, Taeko■ Main theme

Virus infections, such as influenza A epidemic, Ebola

We a n a l y z e t h e m o l e c u l a r m e c h a n i s m o fhemorrhagic fever, Middle East respiratory syndrom, Zika

embryonic development by using the mostvirus infection are important diseases and outbreaks

advanced methods such as imaging, optogenetics

of newly emerging viruses are serious problems forand transgenic mouse technologies. We evaluate

modern society. Higher animals, including humans, aremathematical modeling by using transgenic mice andgenetically equipped with mechanisms, collectively

seek to understand the principles of developmental

known as innate immunity, to counteract viral infections.

dynamics.

During the course of replication, many viruses generate
double-stranded (ds)RNA, which is virtually absent innormal cells and likely serves as a "foreign molecule"in cells. An RNA helicase, RIG-I, functions as a sensor
for viral dsRNA. RIG-I is composed of three domains : a
Caspase recruitment domain (CARD), a DExD/H helicase
domain, and a C-terminal domain (CTD)(Figure). CTDsenses viral dsRNA produced in the cytoplasm, leading
to a conformational change. This conformationalchange releases CARD, which signals to downstream,
resulting in the activation of genes including those fortype I interferon and other cytokines. The purpose of our
project is to clarify the molecular mechanism underlying
the antiviral innate immunity regulated by RIG-I, and todevelop new diagnostic and therapeutic means for viral
infections.

http://www.virus.kyoto-u.ac.jp/Lab/

http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden2012/English/index.html

Kageyama/index_English.html

DIVISION OF INTEGRATED LIFE SCIENCE

25

Division of Integrated
Life Science

Laboratory of Ultrastructural Virology■ Professor■ Assistant Professor

NODA, Takeshi
NAKANO, Masahiro■ Main theme
Virus infections are accompanied by numerous
ultrastructural changes in viral and cellularcomponents. Our laboratory has been investigating
the replication mechanism of influenza and Ebola
viruses from the ultrastructural point of view, by using
different microscopic methods such as electron
microscopy and high-speed atomic force microscopy.
Visualization and characterization of the virus life
cycle at the nano-mesoscopic level give us uniqueknowledge and novel paradigms, which will advanceour understanding of molecular basis of the replication
mechanism.

Scanning electron micrograph of Ebola viruses budding fromcell surface.

26

DIVISION OF INTEGRATED LIFE SCIENCEDIVISION OF SYSTE
SYSTEMIC LIFE SCIENCEThis division consists of 19 laboratories including seven cooperativelaboratories from Institute for Virus Research, Institute for Advancement ofClinical and Translational Science, Institute for Frontier Medical Science,
Radiation Biology Center and RIKEN Center for Development Biology. 35
graduate students are accepted in the Master’s Program annually, and
14 in the Doctoral Program. In this division, education and research arefocused on the elucidation of the fundamentals of molecular and systemic biology, cell biology and immunology. Experimental approaches aretaken with viruses, microorganisms, cultured cells and animals. We pu
pursueeducation and research to elucidate the molecular aspects
spects of Systemic
Syste
Life Science.

Division of SystemicLife Science
Department of Molecular and System Biology

Laboratory of Single-Molecule Cell Biology

Laboratory of Bioimaging andCell Signaling■ Professor■ Assistant Professor■ Assistant Professor■ Professor■ Assistant Professor

WATANABE, Naoki
YAMASHIRO, Sawako
MIZUNO, Hiroaki■ Main theme

MATSUDA, Michiyuki
IMAJO, Masamichi■ Main theme

Our laboratory aims at bridging the gap between

We are visualizing the growth signal transduction

molecular activities and cell physiology in life systems.

cascades in living cells by using biosensors based on

We are trying to visualize signal transduction andthe principle of Foerster resonance energy transfer

cell structure remodeling processes directly in living(FRET). These FRET videos are used to characterize

cells by fluorescence single-molecule microscopy.

the property of each signaling molecule. We are also

We have also recently invented new super-resolution

developing transgenic mice expressing FRET biosensors

microscopy called IRIS, which achieves ultra-

to observe the signaling status in living mice with two-high density labeling of multiple targets in a single

photon excitation microscopes. Recently, by using thespecimen. By direct viewing using these advanced

FRET biosensors we have started to screen chemical

optical techniques, our laboratory elucidates thecompound libraries to inhibit cancer cell growth.

mechanism and the dynamics of pathophysiologicalcell signaling.

http://www.pharm2.med.kyoto-u.ac.jp/

28

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.fret.lif.kyoto-u.ac.jp/

Department of Animal Development and Physiology

Laboratory of Molecular andCellular Biology

Laboratory of Immunobiology■ Professor■ Associate Professor■ Assistant Professor■ Associate Professor

YONEHARA, Shin
SAKAMAKI, Kazuhiro
LEE, Kyung-Kwon■ Main theme

TAKAHARA, Kazuhiko■ Main theme

Apoptosis, or programmed cell death, plays an

Our interest is the induction and control ofimportant role in many biological processes, including

i m m u n i t y . We f o c u s o n d e n d r i t i c c e l l s ( D C s ) ,embryogenesis, development of immune system,

which are a primary antigen-presenting cell in themaintenance of tissue homeostasis, and elimination

immune system. Our current major topics includeof virus-infected and tumor cells. We found cell

the control of DC functions using several types of

surface Fas antigen (Fas), which can directly mediate

glycolipids, resulting in both immune activation andapoptosis-inducing signals into cells by stimulation with

suppression. We are also interested in functions ofagonistic anti-Fas mAbs or Fas ligand (Yonehara S, etlectin molecules expressed on DCs/macrophages thatal., 1989; Itoh N, et al., 1991). Our main research project

recognize polysaccharides on pathogenic agents.

is to understand the intracellular signal transduction

The study includes analyses of interaction between

mechanism of cell death including apoptosis andpolysaccharides and lectins, and subsequentcaspase-independent novel types of cell death,cellular and systemic responses in co-operation withand the biological significance/physiological role of

TLR signaling. In this study, we found that certain

cell death and cell death-regulating molecules. In

lectin-polysaccharide interaction induced immune

conjunction with these studies, we have been trying tosuppressive environment, ameliorating excessive andidentify other cell death-related molecules that playlethal inflammation. By these studies, we would like toa key role in embryogenesis, tumorigenesis or immune

develop new methods to control immune system.

system. Investigations of molecular mechanisms andMouse lectins expressed on DCs/macrophages

physiological roles of cell death and its related molecules
are important for a better understanding of mammalianembryogenesis, tumorigenesis and immune system.

http://www.fas.lif.kyoto-u.ac.jp/

http://zoo.zool.kyoto-u.ac.jp/imm/

DIVISION OF SYSTEMIC LIFE SCIENCE

29

Division of SystemicLife Science

Laboratory of Molecular Cell Biology andDevelopment（Matsuzaki Laboratory）
MATSUZAKI, Fumio■ Visiting Professor（Imai Laboratory）■ Visiting Associate Professor■ Main theme■ Main theme

IMAI, Takeshi

We seek to explore the molecular mechanisms

The mammalian central nervous system is composed

underlying the organization of cells into highly orderedof enormous numbers of neurons. How do these neurons

structures in the developing brain. The vertebrate

establish their identity and form functional neuronalbrain comprises a considerably larger number ofcircuitries? To address this question, we are studying theneurons arranged in a vastly complex functional

mouse olfactory system as a model system. In the mouse

network, which develops from a single layer ofolfactory system, odorants are detected by ~1,000 types

epithelial cells that function as neural stem cells.

of olfactory sensory neurons, each expressing a single

Those cells initially proliferate to expand the stem cell

type of odorant receptor. The olfactory bulb, the primary

population. Subsequently neural stem cells undergo

olfactory area of the brain, receives inputs from olfactory

asymmetric cell divisions to generate self-renewing

sensory neurons through 1,000 sets of glomeruli. Theseand differentiating daughter cells. Thus the transition

inputs are then processed in the olfactory bulb circuits

from the proliferative phase to the neurogenic

and are then sent out to the olfactory cortex. These

phase is critical for the determination of the brain

complex neuronal circuits emerge in an autonomous

size. Asymmetric cell division also appears to play an

fashion based on cell-cell interactions and neuronalessential role in the neuronal production. However,activity after birth, rather than by strict genetic programs.

little is known about mechanisms controlling those

Using the olfactory bulb as a model system, we are

critical events in the brain development.

trying to understand simple rules behind the formation of

We use both an invertebrate (Drosophila) andcomplex neuronal circuitry.

vertebrate (mouse) model systems to understandprinciples for the brain organization such as:
1. How the timing of the proliferative to neurogenictransition is determined in the brain development.
2. How neural stem cells simultaneously generate
self-renewing and differentiating cells.
3. H o w c e l l p o l a r i t y c o n t r i b u t e s t o c o n t r o lasymmetric cell division of neural stem cells.
4. How diverse neuronal types are generated froma single neural stem cell over time.
5. How the global brain architecture is dictated by
the structure and activity of neural stem cells

Dendrite wiring of mitral cells in the mouse olfactory bulb.

http://www.cdb.riken.jp/en/research/laboratory/matsuzaki.html

30

DIVISION OF SYSTEMIC LIFE SCIENCE

http://imai.uijin.com/english.html

（Kitajima Laboratory）■ Visiting Associate Professor

KITAJIMA, Tomoya■ Main theme
In order to maintain genetic information acrossgenerations, cells must segregate chromosomes
equally to daughter cells during mitosis. Meiotic
divisions of the mammalian oocyte, however, are
known to exhibit a higher frequency of errors inchromosomal segregation than in other cell types.
Moreover, oocyte chromosomes behave in ways
distinct from those in other cells, and these uniquedynamics may provide insights into novel mechanisms
for chromosome segregation. Taking advantage of
our established live imaging technologies, we seek
to conduct detailed and comprehensive analysesof the chromosome dynamics and the molecularmachinery that underlies chromosome segregation
during mammalian oocyte meiosis. We also seek to
identify the causes behind age-related increases inchromosome segregation errors during oocyte meiosis.

Prometaphase belt of chromosomes

http://www.cdb.riken.jp/lcs/index_en.html

DIVISION OF SYSTEMIC LIFE SCIENCE

31

Division of SystemicLife Science
Department of Signal Transductions

Laboratory of Molecular Neurobiology

Laboratory of Genetics■ Professor■ Associate Professor■ Professor■ Associate Professor

NEGISHI, Manabu
KATOH, Hironori■ Main theme
Outline of Teaching Activities

IGAKI, Tatsushi
OHSAWA, Shizue■ Main theme
Our research focuses on the molecular basis of

The laboratory provides seminars which review andcell-cell communication that governs tissue growth,

discuss recent progress in molecular mechanisms of

homeostasis, and cancer. We take advantage of theneuronal functions

powerful genetics of Drosophila.

Outline of Research Activities
The main themes of research in this laboratory■ Research subjects:
1. Mechanism of cell competition

are the molecular mechanisms underlying neuronal

2. Genetic basis of tissue growth regulation

network formation and neuronal signal transductions.

3. Molecular basis of tumor progression and

1. Neuronal functions and signal transductions of
GTP-binding proteins
2. Molecular mechanisms for axon guidance

metastasis
4. Logic for morphogenesis from folded epithelial
sheets3. Regulatory systems of synaptic transmission
4. Signal transduction of neuronal polarity formation

Left:Polarity-deficient cells (green; losers) are eliminated from
epithelium by wild-type cells (magenta; winners) through cellcompetition.
Right:Malignant tumor cells (magenta) are invading andmetastasizing from the eye disc to the brain (blue) in Drosophila
larva.

http://www.negishi.lif.kyoto-u.ac.jp/e/Top.html

32

DIVISION OF SYSTEMIC LIFE SCIENCE

http://www.lif.kyoto-u.ac.jp/labs/genetics/

Department of Functional Biology

Laboratory of Functional Biology■ Professor■ Associate Professor■ Assistant Professor

KAKIZUKA, Akira
IMAMURA, Hiromi
SASAOKA, Norio■ Main theme
Using animal models of human diseases, such asneurodegenerations, cancers, and obesity-relateddiseases, and using metabolite imaging techniques,
we aim to elucidate molecular bases of such diseases
and develop new strategies to cure or prevent them.
One of the main features of life science researchin the coming years will be that the results obtained
from fundamental research should ideally bedirectly connected to the good of society. From thisstandpoint, in addition to handling topics with highscientific significance, we aim to contribute to thedevelopment of treatments for neurodegenerative
diseases, cancers, and obesity-related diseases fromour research results.
We hold the same view on scientific education,and through training individuals to communicate theirideas logically yet effectively, as well as by nurturing
their creativity, in addition to strengthening theirpractical research skills, we aim to cultivate opinion
leaders standing at the core of life science research inthe 21st century.

http://www.funcbiol.lif.kyoto-u.ac.jp/

DIVISION OF SYSTEMIC LIFE SCIENCE

33

Division of SystemicLife Science
Department of Biology Education and Heredity

Laboratory of Science Communication

Laboratory of Bioeducation■ Professor■ Professor

HEJNA, James Alan

■ Main theme
Our laboratory engages in the development
and implementation of new approaches to the

CHISAKA,Osamu■ Main theme
Our laboratory has been trying to improve study
materials on biology.

inter nationalization of science education andcommunication, based on principles of active
learning. The particular challenges we are addressing
often involve overcoming the differences in culture
and pedagogical traditions between Japaneseand Western societies. Our efforts are chiefly inthe educational arena, aimed at training the next
generation of scientists to communicate theirknowledge and expertise not only to the international
scientific community but locally to the citizens who
ultimately support basic research. Our activities entail
the following:
1. Increasing the exposure of Japanese students toforeign peers. We are forging new partnerships
with foreign universities to foster joint courses,
using live Internet connections, with active
student participation in English.
2. Establishing partnerships with foreign universities
to encourage short-term reciprocal exchangesof graduate students for collaborative research.
3. Expanding the opportunities for students topresent their research in English to a broad
audience.

34

DIVISION OF SYSTEMIC LIFE SCIENCE

1. Introduction of moder n topics into study
materials on biology
2. Introduction of active learning methods into
biology lectures in English
3. Exploitation of new biology lab course protocols
and materials

Laboratory of Chromosome Function andInheritance■ Associate Professor

Laboratory of Science Communication
and Bioethics

CARLTON, Peter■ Main theme■ Main theme

We aim to understand the mechanisms that

In our laboratory, we aim to identify essential issues

enable the transmission and maintenance of thein the interface between biostudies and the society,genome across cell divisions. We combine super-

and to propose possible actions or solutions.

resolution microscopy and other advanced imaging
techniques with molecular genetics to study
chromosome dynamics in meiosis, as well as the rolesof epigenetic modification of chromatin during DNA
repair.
Our current resrarch focuses on the following
areas:

Currently, we are focusing on the following threeareas.
1.Theoretical and practical analysis of science
communication.
In addition to organizing practical activities suchas "Genome Square", a public event (http://hiroba.
genome-sci.jp/ in Japanese language only), we•Functional analysis of epigenetic modifications inanalyze the effects and significance of science

DNA repair

communication. This includes the communication•Understanding mechanisms of chromosome

between scientists and the general public, and thatdynamics and regulation during meiosis

among scientists and scientific communities.

•Functional analysis of epigenetic modifications
during differentiation of mammalian cells•Analysis of chromosome structures using superresolution microscopy

2. Analysis of bioethical issues in biostudies.
We study ethical, legal and social implications ofbiostudies such as human genome research andhuman stem cell research.
3. Analysis of modern history of biostudies.
We analyze the development and changes ofbiostudies in the last 20 to 30 years through literature
surveys and interviews with scientists.

www.carltonlab.org

DIVISION OF SYSTEMIC LIFE SCIENCE

35

Division of SystemicLife Science
Department of Mammalian Regulatory Network

Laboratory of Cell Regulation and
Molecular Network

Laboratory of Viral Oncology■ Professor■ Assistant Professor■ Professor■ Associate Professor

SUGITA, Masahiko
MORITA, Daisuke■ Main theme

TOMONAGA, Keizo
HIJIKATA, Makoto■ Main theme

Full attention of this laboratory has been

The researches carried out in our laboratory are

directed to previously unappreciated aspects offocused on several RNA viruses, including bornavirus,

the acquired immunity that we call “lipid immunity”.

influenza virus and hepatitis C virus. All our projects

Unlike conventional MHC molecules that present

aim to understand the fundamental mechanisms ofprotein-derived peptide antigens, molecules of thethe replication and pathogenesis of these viruses.

human group 1 CD1 family (CD1a, CD1b, CD1c)

We are investigating the replication and persistent

mediate presentation of “lipid” antigens to specific T

mechanism of the bornavirus in the cell nucleus.

lymphocytes. In addition, we have recently identified

The understanding the biological significance of thea novel lineage of antigen-presenting molecules,

endogenous element of bornaviruses in mammaliantermed LP1, capable of mediating presentation of

genomes is one of the main focuses of bornavirus“lipopeptide” antigens. By taking cell biological,

researches. We also aim to develop a novel RNA virus

immunological and lipid chemical approaches, thisvector using bornavirus, which can express stablylaboratory wishes to establish a molecular and cellularfunctional small RNAs. In Influenza virus researches

basis for lipid immunity and determine how CD1 andwe examine the response of host cells to the virus

LP1 have been evolved to function critically in host

infection. The understanding of the moleculardefense. An important extension of this research is amechanism of tumorgenesis caused by hepatitis

challenge for developing a new type of lipid-based

C virus infection is also the main purpose of ourvaccines against cancer and microbial infection.

laboratory.

http://www.virus.kyoto-u.ac.jp/Lab/

http://www.virus.kyoto-u.ac.jp/virus/

SugitaLab.html

ganvirus.html

36

DIVISION OF SYSTEMIC LIFE SCIENCE

Laboratory of Cell Division and
Differentiation

Laboratory of Genetic Information■ Professor■ Assistant Professor■ Assistant Professor■ Professor

TOYOSHIMA, Fumiko
ODA, Yukako
MATSUMURA, Shigeru■ Main theme

SHIMIZU, Akira■ Main theme

Stem cells in adult tissues exist in a quiescent

Major goal of research in this laboratory is tostate. When they are needed in tissue homeostasis

understand molecular and cellular mechanisms

o r r e p a i r, t h e y e x i t q u i e s c e n t s t a t e , u n d e r g o

underlying highly systemic functions of living things,

symmetric/asymmetric cell division, and give rise tosuch as immune and neural systems. For this purpose,

differentiation-committed progenitor cells. Our groupstructure and regulation of genetic information

seeks to explore the molecular mechanisms underlying

responsible for such systemic functions are beingoriented cell division, stem cell quiescence, and cell

analyzed using model animals, for example,

fate determination. We want to know how stem cells

transgenic or gene disrupted mice. Our research is

response to the changes in the balance of body

focused on the following subjects:

homeostasis during life events, including pregnancy.

1. A n a l y s i s o f m o l e c u l a r m e c h a n i s m s a n d

Our research is focused on the following subjects:

regulation of chromatin modification, gene
expression, gene rearrangements and RNA

1, Oriented cell division in culture cells and mouse
tissues.
2, Quiescence VS Proliferation/differentiation ofstem cells.
3, Proliferation and differentiation control of adultstem cells during pregnancy.
.

processing during lymphocyte differentiation.
2. Making and characterization of model miceof immunodeficiency or autoimmune byintroduction of, or targeted disruption ofinterleukin, immunoglobulin or other genes.
3. Analysis of molecular and cellular mechanism for
lymphocyte mobility and formation of immunomicroenvironment during development andimmune reaction.

http://www.virus.kyoto-u.ac.jp/Lab/
toyoshima.html

DIVISION OF SYSTEMIC LIFE SCIENCE

37

Division of SystemicLife Science

Laboratory of Bio-functions Biomaterials

Laboratory of Cellular and Molecular
Biomechanics■ Professor■ Associate Professor■ Assistant Professor■ Professor■ Associate Professor■ Assistant Professor

TABATA, Yasuhiko
YAMAMOTO, Masaya
JO, Jun-ichiro■ Main theme

ADACHI, Taiji
INOUE, Yasuhiro
KAMEO, Yoshitaka■ Main theme

The main objective of our department is to

Our research group aims to clarify the mechanisms

proceed the research and development of methods,

by which cells sense mechanical stimuli and regulate

procedures, and technologies applicable to basic

their activities in tissue adaptation, regeneration

research of biology and medicine, and medicines

and stem cell differentiation in morphogenesis.

(therapy, diagnosis, and prophylaxis) from the

To better understand the mechano-regulation of

viewpoint of material sciences. The biomedical

these dynamical processes through the complex

materials (biomaterials) to use in the body and tohierarchical structure-function relationships, bridging

contact biological substances are being designed andcreated from biodegradable and non-biodegradable
materials. Our goal is not only to carry out researchesof tissue regenerative therapy (tissue engineering, celltransplantation, cell research, and drug discovery),drug delivery system (DDS), biomedical engineering,and stem cell technology, but also put the researchspatial and temporal scales from microscopic
molecular/cellular activities to macroscopic tissue
behaviors is very important. Based on multiscalebiomechanics, our group is involved in the integrated
biomechanics and mechanobiology researches ofmodeling and simulation combined with experiments,
focusing on mechano-biochemical couplings in thesystem dynamics.

results to clinical and practical uses.
1. Biomechanics and mechanobiology studies on stem
■ Research contents• Research and development of cell scaffolds andcell differentiation, morphogenesis, and remodelingin tissue development and regeneration.

local release of bioactive drugs with biomaterials

2. U n d e r s t a n d i n g m e c h a n i s m s o f t i s s u e

for regenerative medicine (regenerative therapy

differentiation and regeneration emerged fromand research)

multicellular dynamics.

• Research and development of biomaterials for
medical development• Research and development of drug delivery
system (DDS) for drug therapy, diagnosis, andprophylaxis• Research and development of biomaterials forstem cells technology and drug discovery

3. Identifying mechanisms of tissue functional
adaptation by remodeling to mechanicalenvironment
4. Elucidation of mechano-biochemical couplingmechanisms in mechanosensory cells.
5. Nano- and microengineering of artificial systems
combined with biomolecular and cellular systems.

Multiscale computational
biomechanics on tissuemorphogenesis

Nano-mechanicalmeasurement of biomolecules

http://www.frontier.kyoto-u.ac.jp/te02/

http://www.frontier.kyoto-u.ac.jp/bf05/

index_en.html

index-e.html

38

DIVISION OF SYSTEMIC LIFE SCIENCE

Laboratory of Genome Damage Signaling■ Professor■ Associate Professor

TAKATA, Minoru
ISHIAI, Masamichi■ Main theme
DNA damage response (DDR) is the fundamental
mechanism that stabilizes our genome. Genome
stability underlies all biological processes. We try
to identify molecules involved in genome stability/
replication stress/DDR by methods such as screening
mutations in human patients, and further analyze theirfunction using genome engineering in various celllines, iPS cells, and model organisms.

http://house.rbc.kyoto-u.ac.jp/late-effect

DIVISION OF SYSTEMIC LIFE SCIENCE

39

Organization (2016)
DIVISION OF INTEGRATED LIFE SCIENCE
Department
Gene Mechanisms

Cell andDevelopmental Biology

Plant Gene andTotipotency

Applied Molecular
Biology

Responses toEnvironmental Signals
and Stresses

Laboratory
Chromosome
Transmission
Gene Biodynamics
Cell Cycle Regulation

Professor

Associate Professor

Lecturer

Assistant Professor

NAKASEKO,Yukinobu
ISHIKAWA,Fuyuki

Cell Recognition and
Pattern Formation

UEMURA,Tadashi

Signal Transduction

NISHIDA,Eisuke

SHIRAISHl,Hideaki
Miyoshi,Tomoichiro

KUSAKABE,Morioh

Plant Molecular Biology KOHCHl,Takayuki
Molecular and Cellular
SATO,Fumihiko
Biology of Totipotency
Biosignals and
NAGAO,Masaya
Response
Applied Molecular
FUKUZAWA,Hideya
Microbiology
Molecular Biology of
KATAYAMA,Takane
Bioresponse
Plant Developmental
ARAKI,Takashi
Biology
Plasma Membrane
and Nuclear Signaling
Genome
MATSUMOTO,Tomohiro
Maintenance1

Molecular andDevelopmental Biology
Developmental*
KENGAKU,Mineko
Neurobiology2
Molecular and Cellular
FUJITA,Takashi
Immunology3
Mammalian Molecular
Molecular and Cellular Biology3
Biology *Developmental
KAGEYAMA,Ryoichiro
Dynamics3
Ultrastructural Virology3 NODA,Takeshi

NISHIHAMA,Ryuichi
ENDO,Tsuyoshi

SADAIE,Mahito
USUI,Tadao
HATTORI, Yukako
KONDO,Takefumi
MIYATA,Yoshihiko
YAMAOKA,Shohei
SUETSUGU,Noriyuki
IFUKU,Kentaro

KAMBE,Taiho

MIYAMAE,Yusaku
YAMANO,Takashi
KAJIKAWA,Masataka

MASUDA,Seiji

KATOH,Toshihiko

ENDO,Motomu
YOSHIMURA,Shigehiro

KUMETA,Masahiro
FURUYA,Kanji

KATO,Hiroki

OHTSUKA,Toshiyuki

KOBAYASHI,Taeko
NAKANO,Masahiro*Cooperation Course 1) Radiation Biology Center, 2) Institute for Integrated Cell-Material Sciences (iCeMS), 3) Institute for Virus Research

DIVISION OF SYSTEMIC LIFE SCIENCE
Department

Laboratory
Professor
Single-Molecule Cell
WATANABE,Naoki
Molecular and System Biology
Biology
Bioimaging and Cell
MATSUDA,Michiyuki
Signaling
Molecular and Cellular
YONEHARA,Shin
Biology
Animal Development
Immunobiology
and Physiology
Molecular Cell Biology
MATSUZAKI,Fumio8
and Development **Molecular
NEGISHl,Manabu
Neurobiology
Signal Transductions
Genetics
IGAKI,Tatsushi
Functional Biology
Functional Biology
KAKIZUKA,Akira
ScienceCommunication andBioethics
Biology Education and Science
HEJNA,James Alan
Communication
Heredity
Bioeducation
CHISAKA,Osamu
Chromosome Function
and Inheritance
Cell Regulation and
SUGITA,Masahiko
Molecular Network4
Viral Oncology4
TOMONAGA,Keizo
Cell Division and
TOYOSHIMA,Fumiko
4
Differentiation
5
SHIMIZU,Akira
Mammalian Regulatory Genetic Information
Network *Bio-functions
TABATA,Yasuhiko
6
Biomaterials
Cellular and Molecular
ADACHI,Taiji
Biomechanics6
Genome Damage
TAKATA,Minoru
Signaling7

Associate Professo

Lecturer

Assistant Professor
YAMASHIRO,Sawako
MIZUNO,Hiroaki
IMAJO,Masamichi

SAKAMAKl,Kazuhiro

LEE,Kyung-Kwon

TAKAHARA,Kazuhiko
IMAI,Takeshi 8
KITAJIMA,Tomoya 8
KATO,HironoriOHSAWA,Shizue
IMAMURA,Hiromi

Enomoto,Masato
SASAOKA,NorioCARLTON,Peter
MORITA,Daisuke
HIJIKATA,Makoto
ODA,Yukako
MATSUMURA,Shigeru
YAMAMOTO,Masaya

JO,Jun-ichiro

INOUE,Yasuhiro

KAMEO,Yoshitaka

ISHIAI,Masamichi*Cooperation Course 4) Institute for Virus Research, 5) Institute for Advancement of Clinical and Translational Science, 6) Institute for Frontier Medical Sciences,
7) Radiation Biology Center**Collaboration Course 8) RIKEN Center for Development Biology

Organization

41

Map & AccessGetting to Kyoto University

URL: http://www.kyoto-u.ac.jp/en/accesss//

Faculty of Medicine Bldg.F □RIKEN Center for Developmental Biology▼Laboratory of Moleculer Cell Biology
and Development

Laboratory of Bioimaging and Cell Signaling ▼KYOTO

South Campus Research Building for □Integrated Life Sciences / Building G
KOBE

Laboratory of Chromosome Transmission ▼Laboratory of Cell Cycle Regulation ▼Laboratory of Cell Recognition and ▼Pattern Formation
Laboratory of Plasma Membrane and ▼Nuclear Signaling
Laboratory of Molecular and Cellular Biology ▼Laboratory of Immunobiology ▼Laboratory of Molecular Neurobiology ▼Laboratory of Science Communication ▼Laboratory of Bioeducation ▼Graduate School of Biostudies (Oﬃce) ▼OSAKA

to Kokusai kaikan

Kitaoji St.

Science Frontier Laboratory □Higashi-ichijo

Karasuma Imadegawa

Imadegawa St.

Kawaramachi St.

Karasuma St.

Horikawa St.

Radiation Biology Center □Laboratory of Genome Maintenance ▼Laboratory of Genome Damage Signaling ▼Kyoto Imperial Palace

Laboratory of Functional Biology ▼Marutamachi St.

Faculty of Medicine Bldg.A □Oike St.

Laboratory of Single-Molecule Cell Biology ▼Faculty of Pharmaceutical □Sciences Main Bldg.

Gojo St.
Karasuma Line

Shitijo St.

Higashioji St.

1

Konoe St.

Kawabata St.

Marikoji St.

Faculty of Medicine Campus /Faculty of Pharmaceutical Science Campus

Shijo St.

Hankyu Ry.

to Osaka

Laboratory of Genetics ▼Tozai Lineto Osaka

Kyoto Sta.
Kintetu Line

to Nara□ Institute for Virus Research Main Bldg.
▼ Laboratory of Molecular and Cellular Immunology▼ Laboratory of Developmental Dynamics▼ Laboratory of Ultrastructural Virology▼ Laboratory of Cell Regulationand Molecular Network▼ Laboratory of Cell Division and Diﬀerentiation□ Institute for Frontier Medical Sciences (East Bldg.)
Kasuga St.

▼ Laboratory of Bio-functions Biomaterials▼ Laboratory of Cellular and Molecular Biomechanics□ Molecular Biology Research Bldg.
Faculty of Medicine Center for Genomic Medicine▼ Laboratory of Mammalian Molecular Biology▼ Laboratory of Viral Oncology▼ Laboratory of Genetic Information

42

Map & AccessNorth Campus Research Building □for Integrated Life Sciences
Laboratory of Gene Biodynamics ▼Laboratory of Plant Molecular Biology ▼Laboratory of Biosignals and Response ▼Laboratory of Applied ▼Molecular Microbiology
Laboratory of Molecular ▼Biology of Bioresponse
Laboratory of Plant ▼Developmental Biology

Faculty of Agriculture (Main Bldg.) □Laboratory of Molecular and ▼Cellular Biology of Totipotency

Faculty of Science (Bldg. No.2) □Laboratory of Signal Transduction ▼to Kurama
Eizan Ry.

Ke

ifu

ku

Lin

e.

2

Mt. Yoshida

Konoe St.

Jingu Marutamachi Sta.

Shirakawa
Shi
a St.

Hyakumanben

Kyodai
Seimon-mae

Keihan Line

Kamo River

DemachiYanagi Sta.

St.
egawa

Imad

anben

to Hyakum

2
North Campus

Hyakumanben

3
1

Imadegawa St.

Sanjo Sta.
to Yamashina

Gion Shijo Sta.

Higashioji St.

N

JR Lineto Tokyoto Osaka

Higashi Ichijo St

Main Gate

Higashioji St.

□ Institute for Integrated
Cell - Material Sciences(iCeMS) Research Bldg.
▼ Laboratory of Developmental
Neurobiology▼ Laboratory of Chromosome
Function and Inheritance3
Konoe St.

Main Campus

Map & Access

43

Contact
Inquiries concerning entrance examination and"Global Frontier in Life Science"
Telephone number+81-75-753-9222

FAX number+81-75-753-9229

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

E-mail address

kyomu@adm.lif.kyoto-u.ac.jp

URL

http://www.lif.kyoto-u.ac.jp/Global_frontier_in_life_science/index.html

Other inquiries
Administration office at Graduate School of Biostudies
Telephone number+81-75-753-9221

FAX number+81-75-753-9247

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

URL

http://www.lif.kyoto-u.ac.jp/e/