PROGRAM
Oral Presentation
1st day, September 7th (Wed)Morning
9:10

10:00
1

Chair: Takaaki Sato (Keio University)
Toward relay synthesis of macrodiolide luminamicin, a potent anti-anaerobic
bacterial agent(1 Graduate School of Infection Control Sciences, Kitasato University,2
1,2, Hiroyasu Ando 1, Shogo Sekikawa 1
1

1,2,, Yoshihiro Watanabe , Yuki Inahashi , Hirokazu Takada 1,Akihiro Sugawara 1,2

1,2

1, Goh Sennari 1,2, Yoshihiko Noguchi 1,2,1,2, Toshiaki Sunazuka 1,2

1,22

1

Synthetic Studies of Daphniphyllum Alkaloids(1110:00

11:15
31

1

Chair: Arihiro Iwasaki (Keio University)

Synthesis and evaluation of rocaglamide derivatives targeting cancer withabnormal expression of transcription factor ASCL1(1 Keio University, 21,2

421, Shun Saito 1,Cancer therapy by in vivo tagging reaction using ruthenium-complex

and derivative of natural peptide.
(1 RIKEN, 21

1
1,2

52, Tsung-Che Chang 1,, Katsunori Tanaka 1,2

Mechanism of action of korormicin A, a selective inhibitor of Vibrio cholerae
Na+-translocating NADH-quinone oxidoreductase(1 Kyoto University, 231

1

Blanca Barquera 31

11:20

12:20

Short Presentation

12:20

13:10

Lunch Break, Tanaka Hinako 1, Jun-ichi Kishikawa 2,1xvii

1Afternoon
13:10

14:40

Poster Discussion (P1-1

14:45

15:35

Chair: Satoshi Ichikawa (Hokkaido University)

6P1-28)Synthetic studies on aculeines, peptide toxins post-translationally modified
by long-chain polyamines(12

University of Shizuoka, 3 National Institute of Technology,

Hakodate College, 4 Kyoto University, 5
Raku Irie 1

1, Sara Takaki 1, Ryoya Wakabayashi 1,Chisato Tani 2

3445Kazuhiro Irie , Ryuichi Sakai , Toshiyuki Kan
7222,

1Synthesis, Structure, and Biological Activities of BPPs from Blarina brevicauda(12Yusuke Yano 1, Ryo Fukuoka 1

12,1

15:35

16:25
8

Chair: Kosuke Namba (Tokushima University)

Studies toward the Enantioselective Total Synthesis of Portimine
Daisuke Sato

9Total Synthesis of Lobatamides(1Shona Banjo 1

11, Soichiro Yasui 1,

Eiko Nakasuji 1, Kana Hayashi 1, Noritaka Chida 1, Takaaki Sato 1
16:25

17:15
10

Chair: Chihiro Tsukano (Kyoto University)

Divergent total synthesis of monoterpenoid indole alkaloids via strictosidine
derivatives(1 Chiba University, 21112, Hayato Ishikawa 1

Synthetic studies on mavacurine alkaloidsxviii

17:1518:05
12

Chair: Masaru Hashimoto (Hirosaki University)

Study on Daphnane and Tigliane Diterpenes isolated from Stellera chamaejasme
L. and Wikstroemia retusa A.Gray as HIV Latency-Reversing Agents
Yuki Hitora

13

Stereostructural Analysis of Flexible Oxidized Lipids and Their FluorinatedDerivatives Using VCD Spectroscopy
Tohru Taniguchi

18:05

18:55

Chair: Yoko Saikawa (Keio University)

14

Studies on cryptic metabolites induced by bacterial membrane vesicles

15

Sponge-derived Lectin Reveals Novel Activation Mechanism of Cytokine Receptors(1 Hokkaido University, 2 Tohoku University, 3 Juntendo University, 4 Northwestern
University, 5125, Yoshio Kodera

5

33xix

4,

2, Yoshikazu Tanaka , Ryuichi Sakai 1

2nd day, September 8th (Thu)Morning
9:10

10:00
16

Chair: Hayato Ishikawa (Chiba University)
Total Syntheses of Guaianolide-type sesquiterpene lactones(1211, Sangita Karanjit 1, Takashi Taniguchi 2,11733, Ryota Sato 1

1

Unified total syntheses of cephalotane-type norditerpenoids
Goh Sennari

10:00

10:50
18

Chair: Shunji Takahashi (RIKEN CSRS)

Azlactone-Forming Enzyme Involved in the Production of Fungal Benzofuran
Compounds.

Kenji Watanabe
19

Biosynthetic mechanisms of the hydroxamic acid group of trichostatin A.
(1 University of Tokyo, 2 JSPS Research Fellow, 3
Ryuhei Nagata 1,2, Kei Kudo 1

1, Kazuo Shin-ya 3

1

10:55

11:55

Short Presentation

11:55

12:45

Lunch Breakxx

1,Afternoon
12:45

14:15

Poster Discussion (P2-1

14:2014:25

Advance Notice

14:25

15:15

Chair: Masaki Kita (Nagoya University)

20P2-28)

Fungal toxin fusicoccin enhances photosynthesis and plant growthby promoting stomatal opening(12Graduate School of

1, Satoru Kinoshita 2, Yuki Hayashi 2
2

Toshinori Kinoshita , Hiroki Irieda

1

1,

1

Z,10Z,13Z

21

via down regulation of AtKO and up regulation of AtGA2ox transcriptional levels
leading low endogenous amounts of GAs in Arabidopsis thaliana(1 Hokkaido University, 2 Research Institute of Innovative Technology for the Earth,3
11, Akihisa Ishii 1, Syotaro Hirota 1,23Yasunori Koda 1,
15:15

16:05
22, Naoki Kitaoka 1, Kaien Fujino 1,1

Chair: Toshiyuki Wakimoto (Hokkaido University)

Structure and mechanism of ion channel complex formed by amphotericin B
in lipid membrane(12Graduate School of Engineering,

34Nagoya University,Science, Kyushu University, 51

1Hiroshi Tsuchikawa 1,3

2

Graduate School of, Yasuo Nakagawa 1,

1

1,4, Wataru Shinoda 2,5,123

Sneeze-inducing protein from the jellyfish, Chrysaora pacifica(1 Keio University, 2 Nagoya University, 3 Tokyo University of Agriculture and1, Yuri Shindo 1

Keiko Kuwata

21, Daiki Inoue 1

1,3

1xxi, Yoko Saikawa

11,

16:05

16:55
24

Chair: Teigo Asai (Tohoku University)

Biosynthetic study of macrolactam antibiotic hitachimycin(1 Tokyo Institute of Technology, 2
1, Sotaro Takahashi 1

Yuichiro Nakazawa 1, Naeko Iwai 2
Tadashi Eguchi
25

1, Shohei Kurihara 1,2, Takeo Usui 2

1,1

Characterization of enzymes catalyzing the stereodivergent nitrocyclopropane
formation
(11

16:55

17:45
26

1

1, Ikuro Abe 1

Chair: Go Hirai (Kyushu University)

Total Synthesis of JBIR-141 that Contains Oxazoline, N-Nitrosohydroxylamine,and 3-Acyltetraminic Acid Moieties(1 Tohoku University, 2 University of Tsukuba, 31527

213Kazuo Shin-ya , Takayuki Doi
Total Synthesis of Euonymine and Euonyminol Octaacetate
Toshiya Nagai

19:00

4

21:00

Award Ceremony & Symposium Mixerxxii

JBIC, 54,

3rd day, September 9th (Fri)Morning
9:10

10:00
28

Chair: Takayoshi Awakawa (The University of Tokyo)
Investigation of novel peptide epimerases to introduce D-amino acid residues intopeptides(121, Zhi Feng 2, Wanlu Xiao 22, Shota Sato 2,Hinata Kato 2, Tohru Dairi 1
29

Fungal flavonoid biosynthesis by an alternative chalcone synthase

Teigo Asai
10:00

10:50
30

Chair: Fumitaka Kudo (Tokyo Institute of Technology)

Isotope-guided metabolomics reveals polar-functionalized fatty-acylated ribosomallyStreptomyces

31

Characterization of a novel C-geranyltransferase LimF and its application for
artificial macrocyclic peptide synthesis(123Yuchen Zhang 121, Dinh Thanh Nguyen 13,, Toru Sengoku , Yuki Goto , Hiroaki Suga 1xxiii

211

10:50

12:05
32

Chair: Midori Arai (Keio University)

Threonyldiaminobutyric Acid Scanning of Polymyxin to Overcome PolymyxinResistance(12Global Station for

Biosurfaces and Drug Discovery, Global Institution for Collaborative Research andEducation, 3
Hokkaido University, 4
Rintaro Kaguchi 1

1,2

4

Sin-ichi Yokota , Satoshi Ichikawa
33, Toyotaka Sato 3

3,

1,2

Isolation, Structure Determination, Total Synthesis and Biological Activity ofBeru'amide, a Scarce Polyketide(1 Keio University, 21, Arihiro Iwasaki 1, Akira Ebihara 12, Kiyotake Suenaga

2,

134(1 ICR, Kyoto University, 2 Graduate School of Technology, Tokyo University ofAgriculture and Technology, 3
45

Sustainable Resource Science,RIKEN Center for6

71Akiko Nagata

1, Kevin Tan Cruzado 1

2

1252,

12

35534,, Hayato Nakagawa 6,

Tatsuya Higashi 4, Atsushi Kittaka 3, Kazuo Nagasawa 2
12:05

13:00

1,7Lunch BreakAfternoon
13:00

13:50
35

Chair: Hiroki Oguri (The University of Tokyo)

Asymmetric Total Synthesis and Structure Revision of Lancilactone C,an Anti-HIV Triterpenoid(1Chihiro Tsukano 1, Hidetaka Kuroiwa 1, Soichiro Suzuki 1, Kazuhiro Irie 1

36

Total synthesis of amycolamicin, a potent broad-spectrum antibioticxxiv,

13:50

14:40
37

Chair: Masato Oikawa (Yokohama City University)

Study of N-glycan from hyperthermophilic archaeon, Thermococcus kodakarensis:
isolation, synthesis, functional analysis(12University, 34Kohtaro Hirao 1

1,2Takaaki Sato 4343, Anna Notaro 3,, Cristina De Castro 3,Koichi Fukase 1,238

Chemical synthesis-driven identification of a scarce anticancer microbial metabolitepresaccharothriolide ZHideaki Kakeya
14:40

15:30
39

Chair: Haruhisa Kikuchi (Keio University)

Design, synthesis, and chiroptical properties of figure-eight macrocycles composedof natural product scaffolds(1 The University of Tokyo, 2 Tokyo University of Science, 3 Tokyo University of40

2
32Tasuku Honda 1
Establishment of “Ring-Size-Divergent” Synthetic Method: Total Synthesis,

1

Structural Revision, Absolute Configuration, and Biological Activity of Terpenoids
Having Five, Six, and Seven-Membered Ether Rings(1Keisuke Nishikawa 111

15:30

16:45
41

12Faculty of Fisheries,

1, Toshiki Niwa 1,1,2

1Chair: Satoshi Yokoshima (Nagoya University)

A Collective Synthesis of Aplisiatoxn and Oscillatoxin Analogues(1 Nagoya University, 2Kohei Hada 1, Yusuke Araki 1, Yoshihiko Nokura 1, Daisuke Urabe 2, Toshio Nishikawa 1

42Synthetic study on Domoic acid
(1 University of Shizuoka, 2Shigeru Nishizawa 1
Shingo Sasaki 1, Hiroto Suzuki 1
1431

11, Toshiyuki Kan

1

Total synthesis of scytonemin, an anti-inflammatory UV absorver
Yutaro Udagawa, Seijiro Hosokawa

xxv

12,1,

Poster Presentation
1st day, September 7th (Wed)P1-1

Phytochemical, Antioxidant, and Silver Nanoparticles Synthesis Studies onOdontonema strictum(1Lokadi Pierre Luhata 1, Toyonobu Usuki 1

P1-2

A high-sensitive insecticidal activity screen system using silkworm first instar larvae
enables efficient pesticide seed compound search(1 Graduate School of Infection Control Sciences, Kitasato University, 2 School of Science,
Kitasato University, 3
12, Kazunari Sakai 3

Yoshihiro Watanabe 1,3P1-3

1,3, Hidetaka Yuge 2,1,3

Effect of rice-derived glucosylceramides and free ceramides on epidermal hydrationand melanogenesis(12Shogo Takeda 1,222

P1-4

1,3, Akari Yoneda 2, Sarita Shrestha 1
1Structural basis for the complex formed by baicalin and berberine
Yoshinori Uekusa

P1-5

Preparation of chemical probes of marine cyclic peptides kapakahines and analysisof their modes of actions.
, Daisuke Arai, Yoichi Nakao

P1-6

Asymmetric total syntheses of preussomrins: stereospecific photoredox reaction ofnaphthoquinone via 1,6-hydrogen shift(1Yoshio Ando 1P1-72

11, Keisuke Suzuki 2Synthetic Studies on Polycyclic Marine Natural Product, Bisgersolanolide
Norihiko Kawasaki-)-Lamellodysidine A

P1-8P1-9

Tokyo Institute ofSynthetic studies of hyphenrone A
Takeshi Kobayashi

xxvi1,

P1-10

Stereoselective Syntheses of trans-Anhydromevalonyl Group-Containing NaturalProducts(11, Yoko Yasuno 1

Tetsuro Shinada
P1-11

11,

1

Total synthesis of zephycarinatines C and D via photocatalytic spirocyclization
Shinsuke Inuki

P1-12

Total Synthesis, Structure Determination and Biological Evaluation of Antibiotic
Cyclopeptide Pargamicin A(12Tetsuya Inaba 1, Yuko Shibuya 2
Hideo Kigoshi
P1-13

2Institute of1,1An efficient synthesis of N-beta-GlcNAc-Asn and unprecedented synthesis ofN-alpha-GlcNAc-Asn(12Yusuke Kobayashi 1

2, Yuya Nakatsuji 2, Hiroshi Naka 2,2

P1-14

Synthetic studies toward the total synthesis of Amphirionin-5(1 The University of Tokyo 2
11, Syuichirou Aniya 1, Daisuke Abe 2,,2, Hirosato Takikawa 1

P1-15

Development of an efficient synthetic method for C3-position modified sialoglycans
and their sialidase inhibitory activity
Keiya Uezono

P1-16catalysis

P1-17MHAT initiated transannular redox cyclization of vinylsilane enables concise
syntheses of habiterpenol and 2,3-epi-habiterpenol(11P1-18, Haruki Taguchi 11A total synthesis of huperzine A starting from adamantane

Naoki Kanoh, Yoshiharu Iwabuchi

xxvii

1

P1-19 Structures and Cytotoxicity of Novel Steroidal Compounds from the Seeds ofDigitalis purpurea

P1-20 ACCeL: a Program for Multiconformational Calculations and its Application to theStructural Analysis of Novel Natural Products(12Biotechnology ResearchKeisuke Fukaya 1,2, Zhiwei Zhang 1, Chang Liu 1, Yasuhiro Igarashi 1,2, Daisuke Urabe 1,2Hericium

P1-21erinaceus) in collaboration with synthetic chemistry(1 Shizuoka University, 23Junhong Wang 1, Jing Wu 1, Xiaonan Xie 2, Shoji Kobayashi 3
Jae-Hoon Choi

1

1, Hirokazu Kawagishi

3,1P1-22 Heterologous production of a new tricyclic peptide marinomonasin
2(1Issara Kaweewan 1, Hiroyuki Nakagawa 2, Shinya Kodani 1
P1-23 Radical SAM enzymes that catalyze cyclophane formation on Tyr and His-containing
motifs in RiPP biosynthesis
234(151,211,3Thi Quynh Ngoc Nguyen , Yi Wei Tooh
411,

111,

1,5Justin Lo Choy , Qi Su , Wei Yang Goh , Gregory Adrian Gunawan ,Fong Tian Wong 51P1-24 Biogenesis and Functionalities of Dictyoquinone, Differentiation Inducing Factor ofSlime Mold Dictyostelium discoideum23(1451Kei Inouye2, Waki Hayase 2, Reina Honda 35, Yoshiaki Takaya 1,243,

P1-25 Search for plants natural products with BMI1 promoter inhibitory activity
23(11231Kazuki Fujii 1
P1-26 Exploring of lipid-soluble vitamin-based compounds that inhibit the growth of thenew coronavirus SARS-CoV-2.

(1 Graduate School of Shibaura Institute of Technology, 2 Center for Advanced Science
122xxviii

1

P1-27

Nostosin and Spiroidesin Analogues from the Cyanobacterium Dolichospermum sp.
(121, Chin-Soon Phan 1

P1-28

Graduate School of2

Chemical conversion of dimeric pyranonaphthoquinone pigments from aphidsxxix

1,22nd day, September 8th (Thu)P2-1

Molecular networking analysis of Korean bee pollens and their COMT inhibitory
activities(1Shizuoka, 2 School of Food and Nutritional Sciences, University of Shizuoka,
31, Sara Hoshino 2P2-2

3

1,2Luminescence of Cypridina luciferin with human alpha 1-acid glycoprotein
Shusei Kanie

P2-3

Molecular mechanism of target receptor selectivity of paraherquamide A(1 Graduate School of Agriculture, Kindai University, 2P2-4

Development of less aggregative derivatives of pradimicin toward its glycobiologicalapplications(1 Nagoya University, 2 Tokyo Institute of Technology, 345RIKEN, 6
1P2-5112, Yasuhiro Igarashi 3,Yukishige Ito 4,5, Yu Nakagawa 1,5,6
Preparation of domoic acid and kainic acid analogues using the cyclases, andevaluation of their toxicities(1 Graduate School of Agricultural Science, Tohoku University, 2
34

1
1,4Frontier

1, Yuichi Kotaki 2, Ryuta Terada 3

1Yuta Kudo , Yuko Cho , Keiichi Konoki

111P2-6

Total synthesis of indole S, O-bisdesmoside, calanthoside B

P2-7

Synthetic studies on rubioncolin B and its related compounds(11P2-8, Shuji Akai 11Synthetic Study of tetrapetalone A by Nucleophilic Aromatic Substitution(1P2-9Hiroki Deguchi 1, Kengo Hanaya 1, Takeshi Sugai 1, Shuhei Higashibayashi 1
Synthetic Studies of the Macrocyclic Lactam Structure in Zetekitoxin AB(1 Graduate School of Engineering, Tokyo University of Agriculture and Technology,
2Hayate Ishizuka 1, Keiichi Konoki 22, Kazuo Nagasawa 1xxx,

P2-10Synthetic Studies of Ansellones and Evaluation of Reactivating HIV Latent Infection(121, Kanae Nakahara 11P2-1121, Towa Abe 22,1Synthetic study on Mytilipin C(1 Hokkaido University, 211,21P2-12, Koichi Tsuji 11,1

Asymmetric total synthesis of nesteretal A using sequential acetal cyclization reaction(11P2-13, Hideki Kitsukawa 1, Toyoharu Kobayashi 1, Hisanaka Ito 1

Phosphazene base-catalyzed hydroamination of aminoalkenes for the construction ofisoindoline scaffolds: Application to the total synthesis of aristocularine

P2-14

Total Synthesis of Isoflavone Natural Products and Discovery of Pancreatic Cancer
Drug Candidate Compounds(121, Nguyen Ngoc Thanh Luan 1, Ruka Arata 1, Suresh Awale 2,Naoki Toyooka 1
P2-15

Synthetic Studies on Urauchimycin D and Antimycin BYuka Tanaka, Tetsuya Satoh, Yoshinosuke Usuki

P2-16
an anti-dormant mycobacterial substance2(1Yuki Nakatani 1, Hiroki Nonaka 211P2-17

212

1
1, Naoyuki Kotoku
Regioselective Hydrosilylation and Rapid Derivatization of Alkynes Using Glycidyl
Silanes and Its Application to Natural Products(1Akihiro Sugawara 1

P2-18,2

1, Yusuke Sasano 1, Haruhisa Kikuchi 1,2

Catalytic substrate-selective silylation of primary alcohols via remote functionalgroup recognition(1 ICR, Kyoto University, 2
Yoshihiro Ueda 1

31, Kiyosei Takasu 2, Takeo Kawabata 1,3xxxi

P2-19 Highly sterically hindered peptide bond formation between a,a-disubstituted a-aminoacids and N-alkyl cysteines using a,a-disubstituted a-amidonitrile(1Wang Xiaoling 1, Jing Li 1, Yujiro Hayashi 1
P2-20 Isolation, Identification, and DFT-based Conformational Analysis ofSesquikarahanadienone and its Congeners from Freshwater Dothideomycetes
Neohelicascus aquaticus KT4120(1 Faculty of Agriculture and Life Science, Hirosaki University, 2 Institute of NaturalAyane Hayasaka 1,1, Katsuhiro Konnno 2, Kazuaki Tanaka 1,1P2-21 Study on the crystal conformation and the TJ opening mechanism of MA026, a cyclicpeptide(123High Energy Accelerator Research
451

23

3

53, Yoshio Hayashi , Toshiya Senda , Takeo Usui4,

4P2-22 Conformational analysis of flexible ellagitannins
2(1121, Yoshinori Saito 1, Takashi Tanaka 1

P2-23 Next generation natural product chemistry by the precise engineering of type Ipolyketide synthase(1 AIST, 2 N2PC, 3Kei Kudo 1

1Reiko Ueoka 12, Ikuko Kozone 2, Noritaka Kagaya 2,23, Haruo Ikeda 3, Kazuo Shin-ya 1

P2-24 Identification and functional analysis of a new type of Z,E-mixed prenyl reductase
from mycobacteria(1 Niigata University Graduate School of Science and Technology, 2 Niigata University
3Tohru Abe 1

222, Yoshitaka Tateishi 2,3, Daijiro Ueda 1

1

P2-25 Isolation of interesting secondary metabolites by OSMAC approach(1 RIKEN CSRS, 2 Waseda University, 3 University of Shizuoka, #1
1,2#
Toshihiko Nogawa 1Kazuko Yoshida

11, Hiroyuki Koshino

11,

1,3#

P2-26 Isolation of biologically active compounds from the methanol extract of kuji amberusing the yeast ubiquitin ligase RSP5 mutant strain(1Seiya Tanba 1

2
13, Hiroshi Takagi 2, Hiroyuki Koshino 3xxxii

1

P2-27

Chemical studies on bitter principle, lascivol and the related compounds ofTricholoma spp.
(1 Shizuoka University, 21Hirokazu Kawagishi
P2-28

2, Wu Jing 1

122,2

Discovery of novel bifunctional drimane sesquiterpene synthases from marine
bacteria(1 RIKEN CSRS, Natural Product Biosynthesis Research Unit, 2 RIKEN CSRS,Nhu Ngoc Quynh Vo 121, Shunji Takahashi 1xxxiii

1, Hiroshi Takagi 1,