GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITY

2010

INDEXGRADUATE SCHOOL OF BIOSTUDIES
Greeting from the Dean of the Graduate School ………………………………

4

Policy ………………………………………………………………………………………

6

Education curriculum and How to enroll …………………………………………

7

Features of Education …………………………………………………………………

9

OUTLINE and Composition of Departments …………………………… 10
DIVISION OF INTEGRATED LIFE SCIENCE ………………………………… 11
Department of Gene Mechanisms ………………………………………………… 12
Laboratory of Chromosome Transmission
Laboratory of Gene Biodynamics
Laboratory of Cell Cycle Regulation
Laboratory of Molecular Inheritance
Department of Cell and Developmental Biology ……………………………… 14
Laboratory of Cell Recognition and Pattern Formation
Laboratory of Signal Transduction
Department of Plant Gene and Totipotency …………………………………… 15
Laboratory of Plant Molecular Biology
Laboratory of Molecular and Cellular Biology of Totipotency
Department of Applied Molecular Biology ……………………………………… 16
Laboratory of Biosignals and Response
Laboratory of Applied Molecular Microbiology
Laboratory of Molecular Biology of Bioresponse
Department of Responses to Environmental Signals and Stresses …………… 17
Laboratory of Plant Developmental Biology
Laboratory of Plasma Membrane and Nuclear Signaling
Department of Molecular and Developmental Biology ……………………… 18
Laboratory of Genome MaintenanceLaboratory of Nanobiology
Laboratory of Developmental Neurobiology
Department of Molecular and Cellular Biology ………………………………… 20
Laboratory of Molecular Cell Biology
Laboratory of Mammalian Molecular Biology

DIVISION OF SYSTEMIC LIFE SCIENCE …………………………………… 21
Department of Molecular and System Biology…………………………………… 22
Laboratory of Neuroscience
Laboratory of Bioimaging and Cell Signaling
Laboratory of Immunology and Cell Biology

INDEX
Department of Animal Development and Physiology ………………………… 23
Laboratory of Molecular and Cellular Biology
Laboratory of Immunobiology
Laboratory of Molecular Cell Biology
Department of Signal Transductions ……………………………………………… 26
Laboratory of Molecular Neurobiology
Laboratory of Membrane Biochemistry and Biophysics
Department of Functional Biology ………………………………………………… 27
Laboratory of Functional Biology
Department of Biostudies and Society …………………………………………… 27
Laboratory of Science Communication and Bioethics
Department of Mammalian Regulatory Network ……………………………… 28
Laboratory of Cell Regulation and Molecular Network
Laboratory of Viral Oncology
Laboratory of Cell Division and Differentiation
Laboratory of Genetic Information

Map & Access ……………………………………………………………………… 30
Contact ………………………………………………………………………………… 32

Greeting fromthe Dean of
the Graduate School
Dean: YONEHARA
YONEHARA, Shin
Shin, D
D.Sc.
Sc

THE BEGINNING OF A NEWERA OF LIFE SCIENCES
In the past, most of the important discoveries in

Biostudies has the purpose of training people capableof supporting the human society in the 21st century,
based on a general understanding of the life sciences.

the field of life sciences were made accidentallyor passively as a result of the diligent efforts of the

The three goals of the graduate school

individual researcher. New frontiers were opened(1) Provide education for pursuing the new biostudies

based on the immediate needs of the individual,

at the world's top level

without the support of a systematic educational

To meet the demands of the industry, college

system. The researchers entered the field of lifeand research institutes, individuals are educated insciences incidentally under the past academic system.

the life sciences and master the techniques for the

Therefore, by getting organized, these life scientists

society needs.

could systematize the previously incidental education
and research and establish a new academic system(2) Train individuals to apply the new life sciences

for the study of life sciences. This new idea does not

for the protection of the global environment andconflict with the existing departments and faculties.

for human welfare Integrate the knowledge andAccordingly, the Graduate School of Biostudies wastechnology in the old fields of science, agriculture,founded in 1999. The aim is to nurture individuals who

medicine and pharmacology, and nurture indi-

can value the future of life and its dignity by attempts

viduals who can contribute to the human society into constructively integrate and understand humans,the 21st century.

animals, plants and the environment, through studiesof the cells and genes, the constituent units of the(3) Nurture individuals who can understand the vari-living body. In this way, the individual is to be nurtured

ous vital phenomena of the living organisms as anaturally to have respect for human dignity andsystemic function, and pursue these systemic func-

concern for the environment.

tions
Nurture individuals who will be leaders in the

THE GOALS OF THE GRADUATE SCHOOLOF BIOSTUDIES
Those trained in the fields of science, agriculture,
medicine and pharmacology, where the studies in thehuman society to pursue their activities for the welfare and happiness of humans in the 21st century,
where humans will be living in harmony with otherliving beings.

life sciences were pursued in the past, have independently contributed greatly to the current developments

In order to meet the demands of the changing

of our society. However, the new Graduate School ofsociety in the 21st century, which will be impossible

4

GRADUATE SCHOOL OF BIOSTUDIESto cope with in the current research academic sys-

In the Graduate School of Biostudies, individuals

tem for the life sciences, a new research and edu-

are trained to make a healthy and fair judgment

cation system is installed to breakdown the walls

based on the academic background of the staff

that have hindered the research in the life sciences

and their prospects for the future; and, establish ain the past. There are two courses in the Graduate

new system to evaluate the effects of education

School of Biostudies.

from multiple aspects from the past.

(1) The Division of Integrated Life Sciences: cell development, cell growth, genetic information and cell(3) Activation and flexibility of staff in the human relations

cycle regarded as a multicellular system, and the

Research is pursued by each staff member in-

totipotency, the mechanism of signal transduction

dependently to develop a new life science based

and the responses among the cell, living being andon active exchange among the various laborato-

environment.

ries in the graduate school.

(2) The Division of Systemic Life Sciences: neuroscience, animal development and physiology, immunobiology and others.

(4) Use of current post-doctoral system and evaluationof academic activities
Full use should be made of the current system,
to provide the increasing necessary number of

AIMS OF THE GRADUATE SCHOOL OF BIOSTUDIES

instructors per student, for the intensive training to(1) Training of individuals with the most advanced

become life scientists at an international level, forknowledge of the life sciences for the next genera-true development of a new research field.

tion
The graduate student studies a higher level oflife sciences beyond the structures of past life science-related fields at each undergraduate level tounderstand the integrated life sciences. The goal
is to nurture a new type of individual with creativeand innovative abilities to cope with the various
unknown themes to be confronted by human beings in the next generation.

(2) Training to establish self for society

GRADUATE SCHOOLCHOOL OF BIOSTUDIE
BIOSTUDIESS

5

Policy
Education and admission policy
The field of life sciences is transforming andevolving into an advanced branch of science thatwill build a future for humans. With this global trend
as a backdrop, the Graduate School of Biostudies
was established in 1999 as Japan’s first independent graduate school of biostudies, with the aim ofcreating one of the world’s top research institutions

3. All students are trained to become mature andhighly capable researchers who can collaborate
actively with foreign partners.
4. We offer a variety of educational curriculums including biology, medicine, and related areas.
5. We cultivate students with life ethics and astrong sense of responsibility for the world where
humanity and nature must be harmonized.

and developing human resources who will lead thenext generation in the biostudies field. With a set of

Diploma policy

such basic units of life as "cells," "molecules," and1. In the two-year Master’s program, students must

"genes" as a common language, the Graduate

take 1 credit from essential subjects and at least

School of Biostudies is home to innovative research

9 credits from elective subjects offered by theand educational activities, where concepts aboutschool. In addition, students are required to com-diverse organisms and the environments that com-plete 20 credits of lab experiments and practice.

prise them are integrated to create new values

The degree must be accredited through the ex-concerning the future and respect for life.

amination of a master’s thesis.

In response to diverse, social demands that call

2. In the Master’s program, it is necessary for stu-

for an increasingly sophisticated and complex life

dents to acquire and demonstrate knowledgesciences field, the Graduate School of Biostudies

and capability required for professional re-

strives to develop the following human resources:

searchers in the field.

1) Researchers who explore and discover the ba-

3. In the Doctoral program, students who takesics of life, pursuing the cutting-edge field of bio-the lectures offered by the school and performstudies at the highest level in the world;

the research for PhD thesis must be enrolled for2) Researchers and highly skilled engineers who

3 years (or less by way of exception). Students

contribute to society at public and private re-must take 1 credit from essential subjects andsearch institutions, endeavoring to protect themore than 1 credit from elective subjects. For

global environment and maintain human health,lab experiments and practices, 8 credits are

well-being, and happiness; andrequired. Doctoral students must submit a PhD

3) Educators and highly skilled practitioners who
possess broad knowledge of diverse vital phe-thesis and pass the relevant examinations for the
degree.

nomena of living organisms and who contribute

4. In the Doctoral program, each student must

to society through education, industry, mass me-

demonstrate that he/she has the ability to work

dia, and the public sector.

as an independent researcher for successful

Curriculum organization

5. We cultivate the students with life ethics and acompletion of the program.

1. In Master’s programs, basic knowledge of life
science and research competency are acquired.
2. In Doctoral programs, advanced knowledge
and research competency in life science are
acquired. Moreover, each student is trained to
become a researcher who plays an active roleinternationally as a group leader.

6

GRADUATE SCHOOL OF BIOSTUDIES

strong sense of responsibility for the world, where
humanity and nature must be harmonized.

Education curriculum andHow to enroll
Educational Philosophy
We expect to develop the next generation ofinterdisciplinary leaders in the field of life sciencesby providing the best academic research environment under the supervision of the finest graduate
educators and PhD advisers. We emphasize theimportance of the accomplishment of a researchendeavor as well as academic performance in
lecture, seminar, and laboratory practice. At thesame time, the students are trained for developing the ability to discuss and debate scientificmatters and research outcomes. Students are also
trained to have wide vision and flexible thinking inlife sciences, and are encouraged to go abroad
to attend scientific meetings.

held in February, 2011. The guidelines for admission will be posted in December, 2010 on our
web site (http://www.lif.kyoto-u.ac.jp/e/). The
academic year starts on April 1st or October 1st for
those who cannot obtain "study visa" by the endof March. Thus, applicants can select the starting
date of either April 1st or October 1st. At the timeof application, prospective students must identify
which laboratory head will direct their doctoral
research. Applicants can apply for only one lab.
Thus, applicants should contact the lab head andfully discuss about potential research activities andavailability before filing the application.
Admission examinations for the Doctoral program consist of: 1) an English written test to evaluate reading comprehension and writing ability;“Global Frontier in Life Science”

2) an oral presentation (in English) of a research
project that applicants have conducted; 3) a sub-From 2011, The Graduate School of Biostudies,sequent oral examination to evaluate applicants’

together with The Graduate Schools of Medicine

knowledge of their field, research competency,

and Pharmaceutical Science, will launch "Global

logical thinking skills, and ability to give presen-

Frontier in Life Science", a new joint educational

tations.

program for Doctoral and Master’s students as partof K.U. Profile (Kyoto University Programs for Future2) Master’s Program in "Global Frontier in Life Science"

International Leaders: http://www.opir.kyoto-u.

Our entrance examination for the Master’sac.jp/kuprofile/e/index.html). This program, "Global

program will be held in August, 2011. The guide-

Frontier in Life Science", will be held entirely in Eng-

lines for admission will be posted in April, 2011 onlish, including the entrance examinations, lectures,

our web site (http://www.lif.kyoto-u.ac.jp/e/). The

experiments, and discussions.

academic year starts on October 1 st or April 1 st

Inter national as well as domestic stu-for those who cannot obtain "study visa" by thedents are welcome. In particular, the Schoolend of September. Thus, applicants can selectwelcomes those who show a respect for life

the starting date of either October 1st or April 1st in

and a desire to create a comprehensive andthe next year. Applicants to the Master’s program

cutting-edge field beyond existing disciplinary

can apply for up to two labs, in which they wish toboundaries in the life sciences.

conduct research. Thus, applicants should familiarize themselves with faculty members’ researchinterests and contact lab head(s) to fully discuss

1) Doctoral Program in "Global Frontier in Life Science"prospective research activities and availability
before filing the application.

The three graduate schools will hold indepen-

Admission examinations for the Master’s pro-dent entrance examinations for this program,

gram consist of: 1) a first set of written examinations

and accept up to ten applicants. Our entranceof English proficiency and knowledge of a special-

examination for the Doctoral program will beized subject; 2) a second written examination on a

GRADUATE SCHOOL OF BIOSTUDIES

7

specialized subject; and 3) an oral examination.

gram

The first set of written examinations is given to all

・"The life-science experiments and exercises 1" (10applicants, and those who pass the first examinations proceed to the second written examinationand the oral examination.

credits) compulsory
・"The life-science experiments and exercises 2" (10credits) compulsory
・Compulsory subject (1 credit)

Lectures held in English
1) Doctoral program
Supplied by The Graduate School of Biostudies
・Frontier in Life Science (compulsory subject: 1 credit)
・Advanced course in Life Science (1 credit)
・Advanced scientific skills (1 credit)・Academic English discussion in Life Science (1 credit)
Supplied by The Graduate School of Medicine
・Advanced course in Medical Science (6 credits)
Supplied by The Graduate School of Pharmaceutical Science・Frontier in Pharmaceutical Science (2 credits)
2) Master’s program
Supplied by The Graduate School of Biostudies
・Basic course in Life Science (compulsory subject: 1 credit)・Basic scientific skills (1 credit)・Basic English discussion in Life Science (1 credit)
・Global frontier in Life Science A (2 credits)
・Global frontier in Life Science B (2 credits)
・Global frontier in Life Science C (2 credits)
・Advanced molecular and cell biology I (2 credits)
・Advanced molecular and cell biology II (2 credits)
Supplied by The Graduate School of Medicine
・Medical Science I (2 credits)
・Medical Science II (2 credits)
・Clinical Science Introduction (2 credits)

Requirements for completing programs
1) Requirements for completing the PhD program
・"The life-science exercises" (8 credits) compulsory
・Compulsory subject (1 credit)
・Elective subjects offered by the graduate school
and other schools. (1 credit or more)
・For graduation, the student must attend three
years or longer and have 10 credits or more. It isalso necessary to pass probation and an examination (thesis defense) upon completion of a PhD
thesis written under the supervision of faculty.
2) Requirement for completing the Master’s pro-

8

GRADUATE SCHOOL OF BIOSTUDIES・Elective subjects offered by the graduate school
and other schools (9 credits)
・For graduation, the student must attend two
years or longer and have 30 credits or more. It isalso necessary to pass probation and an examination upon completion of the Master’s thesis
written under the supervision of faculty.

Features of Education
Features of Education
From 2006 to 2007, we conducted the "Biostudies Career-Development Program" supported by the Ministry of Education, Culture,
Sports, Science and Technology. From 2008,

development of communication skills in English. We encourage and financially support ourstudents who go abroad give talks at international congresses. We also coach them on
their presentation skills.

we have launched the "Program for Developing Pharmaceutical Strategists" as one of the
projects of "Reforming Programs in Education"
in Kyoto University. This joint program with the
Graduate School of Pharmaceutical Scienceis aimed at reforming the educational systemof graduate schools at Kyoto University. Starting in 2011, we will conduct a new program
named "Global Frontier in Life Science". We
are hoping that our students will understandthe essential aspects of the programs and co-4) Workshops organized by students
Graduate students in the life sciences
tend to become isolated in their labs because they are busy working at the bench.
However, it is highly important to communicate with other students studying life scienceinside and outside of our school during thecourse of education. We encourage and financially support the students to organize
and conduct workshops by themselves.

operate with us in achieving these goals.
5) Guidance by multiple supervisors

Outline for Reforming Programs in Education
1) Lectures

We consider that it would be highly stimulating for the students if they could have opportunities to discuss their research and other con-

In the Master’s program, the curriculum is de-cerns with faculty members in addition to theirsigned to make the students systematically un-

primary adviser. In our school, each student isderstand basic life science and its related fields.

strongly encouraged to consult with two ad-

We also offer an inherent lecture for understand-ditional faculty members about his/her current

ing, revealing and cultivating the relationshipresearch and also about career plans. We hope

between life science and society. In our Doctoralthat this practice widens their outlook on the

program, advanced and up-dated topics in life

future direction of life science, and helps themscience are presented, along with seminars at

find their way to the forefront of life science.

the lab to which each respective student belongs.
6) Global 30 (http://www.mext.go.jp/english/news/
2) Training Program for Drug Discovery Technology

1283454.htm)

For the students in the Doctoral program,

The Ministry of Education, Culture, Sports,

two courses in the new Training Program for

Science and Technology has launched theDrug Discovery Technology are offered.

"Global 30" Project for Establishing Core Universities for Internationalization, for the pur-3) Attendance at foreign scientific meetings andlife science communication in English

pose of selecting universities that will function
as core schools for receiving and educat-

It is now very important for a successful

ing inter national students. In 2009, thirteenscientist to give presentations in English, espe-

universities including Kyoto University werecially at inter national congresses. However,selected. These core universities will play auntil recently, the graduate schools in our

major role in dramatically boosting the num-

country scarcely cared about the develop-

ber of international students educated inment of English communication skills for stu-Japan as well as Japanese students studying

dents. Our school has been emphasizing theabroad.

GRADUATE SCHOOL OF BIOSTUDIES

9

Outline and Composition of Departments
Research Laboratories in the Graduate School of Biostudies
We contribute for the improvement of future welfare and happiness of humankind

DIVISION OF
INTEGRATED LIFE SCIENCEDIVISION OF
SYSTEMIC LIFE SCIENCE❖ Genetical mechanism❖ How the brain and the body work・Department of Gene Mechanisms❖ How the body is built

・Department of Molecular and Cellular Biology❖ How the human diseases occur
・Department of Molecular and System Biology❖ How multicellular organisms work・Department of Cell and Developmental Biology
・Department of Plant Gene and Totipotency
・Department of Molecular and Developmental
Biologyginteract with❖ How organisms
environments

・Department of Animal Development andPhysiology
・Department of Signal Transductions
・Department of Functional Biology
・Department of Biostudies and Society❖ Communications・Bioethis
・Department of Mammalian Regulatory Network

・Department of Applied Molecular Biology
・Department of Responses to Environmental
・Signals and Stresses

Living organisms

Human beings

Genes and cells

10Outline and Composition of Departments

DIVISION OF INTEGRATEDRAATED LIFE SCIENCEThis division consists of 18 laboratories including five cooperativelaboratories one from Radiation Biology Center, two from Institute for Virus Research, and two from Institute of Integrated Cell-Material Sciences(iCeMS). Thirty-seven graduate students are accepted in the Master's
Program annually, and 17 in the Doctoral Program. In this division, education and research are focused on the elucidation of basic mechanisms
regulating the chromosome transmission, chromosome replication, RNAarchitecture, cell cycle, cellular transport, cell polarity, signal transduction, growth and development, developmental plasticity, bioconversion,and environmental adaptation. Experimental approaches are taken withmicroorganisms, plants, and animals. We pursue education and research
to elucidate the molecular aspects of Integrative Life Science.

Division of Integrated
Life Science
Department of Gene Mechanism
D
ms

Laboratory of Chromosome Transmission

Laboratory of Gene Biodynamics■ Associate Professor■ Professor■ Associate Professor■ Instructor

NAKASEKO, Yukinobu■ Main theme

INOUE, Tan
SHIRAISHI, Hideaki
FUJITA, Yoshihiko■ Main theme

Main theme in this laboratory is the analysis of

Research in this Laboratory focuses on Synthetic

eukaryotic cell cycle regulation. Especially, regulation

Biology of RNA and RNP (RNA-protein complex).

of chromosome separation and segregation during

Topics of interest include design and development

mitosis has been extensively studied. Fission yeastof new functional RNAs (RNPs), and RNAs (RNPs)-

Schizosaccharomyces pombe is used as a model

based synthetic genetic networks. The design andsystem. This yeast has all basic features involved indevelopment is performed based on the structure ofcell cycle regulation which are conserved among all

naturally occurring RNA molecules and also in vitro

eukaryotic cells. And wide variety of approach canand in vivo evolution technique.

be taken for analysis such as genetical, biochemical,

Further research areas include the analysis ofmolecular biological technique. Identification ofsmall noncoding RNA and flower development

individual genes involved in regulation of the cellof Arabidopsis thaliana. In addition, evolution ofcycle is start point. Elucidation of whole net work ofmulticellularity and oogamy are investigated by

the function of these genes is one of a goal in this

employing Volvox that is known as one of the simplest

research.

multicellular organisms.

Web Site http://kuchem.kyoto-u.ac.jp/seika/

12

DIVISION OF INTEGRATED LIFE SCIENCE

Laboratory of Cell Cycle Regulation

Laboratory of Molecular Inheritance■ Professor■ Instructor■ Professor

ISHIKAWA, Fuyuki
NABETANI, Akira
TARUMOTO, Yusuke■ Main theme

YANAGIDA, Mitsuhiro■ Main theme

Our research activity focuses on the molecular

The aim of this laboratory is to study the mechanism

mechanism of the flow of genetic infor mation.

of chromosome segregation and regulation of the

Chromosomes, the vehicle of genetic materials,

cell cycle that are conserved among eukaryotes.

show both faithful and flexible behaviors, in different

We employ the fission yeast Schizosaccharomycestime scales, from a single round of the cell cycle topombe as a model using a number of mutants

the evolution of species, and in different conditions,

isolated in this laboratory and also human cells using

such as development, aging and cancer. Thesethe RNAi method. Currently, our research is focusedapparently opposite behaviors of chromosomes canon the molecular switch from growth to mitosis, thebe explained by the need of genetic materials to bemechanism of two step proteolysis in anaphase, andtransmitted robustly. We are particularly interested

the assembly of centromere and kinetochore proteins.

in how functional domains of chromosome, such as

We have close collaboration with our sister/brothertelomeres, are established and maintained, and howlaboratory in Okinawa that has a principal researchchromosomes respond to external stimuli, as exemplified

project for understanding the G0 cell maintenance.

by the genetic instability found in cancer cells. We are

The list of publication is available at the web page oftrying to understand these questions by experimental

this laboratory.

approaches based on genetics, biochemistry, andmolecular and cellular biology in various model systems,
such as fission yeast, Xenopus, and mammalian cells.

Telomeres consist of DNA ends and the specialized
protein complex called shelterin, together providing thebasis of telomere structures and functions. Telomeres
adopt two distinct conformations, "semi-open" and"closed" states. The semi-open state facilitates thereactions of trans-acting factors, such as telomerase.
Web Site http://www.lif.kyoto-u.ac.jp/labs/kozo/
Web Site http://www.lif.kyoto-u.ac.jp/labs/fish/index-e.html

DIVISION OF INTEGRATED LIFE SCIENCE

13

Division of Integrated
Life Science
Department of Cell and DevelopDpmentaal Biolo
ogy

Laboratory of Cell Recognition and
Pattern Formation

Laboratory of Signal Transduction■ Professor■ Associate Professor■ Instructor■ Professor■ Instructor

UEMURA, Tadashi
CHISAKA, Osamu
USUI, Tadao■ Main themeNISHIDA, Eisuke
MIYATA, Yoshihiko
KUSAKABE, Morioh■ Main theme

Cells in a variety of developmental contexts sense

We are interested in identifying and elucidating

extracellular cues that are given locally on theirmolecular mechanisms that regulate cellsurfaces, and subsequently amplify the initial signal

proliferation, cell differentiation, cell cycle, aging

to achieve cell polarization. Acquisition of the celland developmental processes. The current topics

polarity is crucial for specialized functions of individual

include 1) regulatory mechanisms and functions ofcell types. We are investigating molecular mechanisms

the MAP kinase cascade pathways, 2) identificationthat control epithelial cell polarization and patternof novel signal transduction mechanisms, 3) molecularformation of neuronal processes with an emphasis

mechanisms for life span regulation, 4) roles of protein

on dendritic geometry. The current research subjects

kinases in cell cycle progression and regulation, 5)

include: 1) To elucidate how cell-to-cell recognition

growth factor signaling mechanisms in developmental

contributes to dynamic cell morphogenetic processes,

processes, 6) regulatory mechanisms for mammaliansuch as planar cell polarity, during development. 2)circadian clock.

To investigate the molecular basis of how neurons
shape their dendritic trees and establish neuralcircuits. In these two topics, we are interested in theroles for cell surface molecules belonging to thecadherin superfamily, regulators of cytoskeleton, andtranscriptional factors. To conduct these studies, weemploy a variety of molecular, cellular, and genetic
technologies, and use Drosophila, vertebrates, andcell lines as materials. Our long-term goal is to shedlight on pathogenesis of human diseases that arecaused by defects in the epithelial or neuronal cellmorphogenesis.

Web Site http://www.lif.kyoto-u.ac.jp/labs/cellpattern/

14

DIVISION OF INTEGRATED LIFE SCIENCEWeb Site http://www.lif.kyoto-u.ac.jp/labs/signal/

Department of Plant Gene and To
otipotenncy

Laboratory of Plant Molecular Biology

Laboratory of Molecular andCellular Biology of Totipotency■ Professor■ Associate Professor■ Instructor■ Professor■ Associate Professor■ Instructor

KOHCHI, Takayuki
FUKUZAWA, Hideya
ISHIZAKI, Kimitsune■ Main theme

SATO, Fumihiko
ENDO, Tsuyoshi
IFUKU, Kentaro■ Main theme

Research in this laboratory focuses on the adaptive

Molecular and cellular biological studies onregulation of growth and development to environmental

totipotency in plant cells have been carried out in thisconditions using model photosynthetic organisms.

laboratory using in vitro cultured cells and transgenic

Topics include mechanism of photomorphogenesis

plants. Especially, cell/organ differentiation fromand meristem development. We study molecularundifferentiated cells, functional differentiations, e.g.

mechanisms of light sensing by photoreceptors andoxygen evolving complex in photosystem II, cyclic

downstream genetic network of signal transduction.

electron transfer and gene regulation in chloroplast,Approaches by molecular genetics and comparative

as well as molecular biology of secondary metabolism,

genomics are taken with Arabidopsis and liverwort

such as biosynthesis of isoquinoline alkaloids in plant(Marchantia polymorpha). In particular, the genetic

cells have been investigated to understand theanalysis of Marchantia is unique and efficient as its

totipotent functions in plant cells. Development

phylogenetically basal position in land plants, haploid-of novel genetic engineering techniques such as

dominant life cycle, and simple transgenesis. Further

differential RNAi, metabolic engineering and synthetic

research areas include the molecular mechanisms

biology of secondary metabolism for industrialof acclimation to shortage of CO2 through so called

application have been also investigated.

"carbon concentrating mechanisms", and the CO2signal transduction pathway to switch on/off gene
expression using green algae Chlamydomonas.
Genome analysis of Marchantia and Chlamydomonas
are also conducted in this laboratory.

Web Site http://www.lif.kyoto-u.ac.jp/labs/callus/

Web Site http://www.lif.kyoto-u.ac.jp/labs/plantmb/

DIVISION OF INTEGRATED LIFE SCIENCE

15

Division of Integrated
Life Science
Department of Applied Molecullar Biolo
D
ogy

Laboratory of Biosignals and Response

Laboratory of Applied Molecular Microbiology■ Professor■ Associate Professor■ Associate Professor■ Instructor

NAGAO, Masaya,
KAMBE, Taiho■ Main theme

ASHIDA, Hisashi
KURIHARA, Shin

■ Main theme

Bio-prospecting, a research strategy searching

Our research focuses on the microbial

for compounds that possess beneficial activity for

enzymes/proteins involved in the metabolism ofhealth from natural sources, is one of the projects inoligosaccharides/glycoconjugates that function in thethis laboratory. Especially, at present, compounds thatinteraction between microbes and animals including

prevent hepatic fibrosis and replication of hepatitis C

human, and also in many biological phenomena. It

virus are the main targets of our bio-prospecting.

includes application of these enzymes/proteins for

We are also studying how organisms perceive
environmental signals and transduce these signals

glycotechnology and glycoengineering in the fields offood, medical and environmental sciences.

into changes in gene expression, focusing mainly on

Current research projects are (1) elucidation

the molecular and cellular basis of metal metabolismof metabolic pathways of intestinal bacteria for(such as uptake, storage, delivery, and maintenanceassimilation of gastrointestinal oligosaccharides andof metal concentration in cells) in mammal.

glycoproteins, (2) application of microbial glycosidases
on syntheses of various bioactive glycoconjugates,(3) elucidation of biosynthetic pathways of uniqueglycosphingolipids in fungi, (4) analyses of metabolism
and function of cytosolic free oligosaccharides
derived from N-glycans in eukaryotes, (5) functional
analyses of ER glycosidases and glycosyltransferases ineukaryotes, and (6) analyses of biological activities ofchitin/chitosan hydrolysates.

Web Site http://www.lif.kyoto-u.ac.jp/labs/molecule/
Web Site http://www.lif.kyoto-u.ac.jp/labs/seitaijoho/

16

DIVISION OF INTEGRATED LIFE SCIENCE

index-e.html

Department of Responses tooEnvironmental Signals and Stresse
esLaboratory of Molecular Biology ofBioresponse

Laboratory of Plant Developmental Biology■ Associate Professor■ Professor■ Instructor

MASUDA, Seiji■ Main theme

ARAKI, Takashi
ENDO, Motomu■ Main theme

Research in this laboratory focuses on the

We are interested in molecular mechanisms

mechanism of messenger RNA maturation in nucleus

underlying plant’s responses to environment. Plants

mediated by a number of proteins and small RNAs.

have evolved plastic developmental programs

Messenger RNA is synthesized as pre-mRNA by RNA

with both genetic and epigenetic basis to adapt

polymerase II complex. Pre-mRNA undergoes thetheir sessile mode of life to changing environment.

multiple processing step, 5' capping, splicing and 3'

Using an angiosperm, Arabidopsis thaliana and a

endprocessing and become mature mRNA. Thenliverwort, Marchantia polymorpha as model systems,

mRNA is exported to cytosol to produce proteins.

we have been investigating (1) regulation of growth

During these processing, a large number of proteinsphase transition (especially, flowering) in response

are conducted to process the each step adequately.

to environmental signals, (2) long-distance systemic

At present, we are focusing on the function of TREX

signaling in control of development, (3) epigenetic

complex, which couples transcription and export ofregulation of apical meristem function, and (4)mRNA. We are also studying mRNA export pathway

origin and evolution of regulatory systems for plastic

in mammalian cells thereby enhancing the protein

development.

production by optimizing the packaging and export
of mRNA.

Web Site http://www.lif.kyoto-u.ac.jp/labs/
bunshioutou/index.html
Web Site http://www.lif.kyoto-u.ac.jp/labs/
plantdevbio/index.html

DIVISION OF INTEGRATED LIFE SCIENCE

17

Division of Integrated
Life Science
Department of Molecular andDevelopmental Biology

Laboratory of Plasma Membrane andNuclear Signaling

Laboratory of Genome Maintenance■ Professor■ Associate Professor■ Instructor■ Professor■ Instructor

TAKEYASU, Kunio
YOSHIMURA, Shigehiro
KUMETA, Masahiro■ Main theme

MATSUMOTO, Tomohiro
HABU, Toshiyuki■ Main theme

We are interested in how the cell signaling is

The spindle checkpoint, our major research

regulated by specific molecular elements. By using a

subject, is a surveillance mechanism to regulate

variety of techniques in biochemistry, molecular andcellular apparatus for compliance with this rule. It is acell biology, and structural biology, we have beenunique negative feedback that converts/amplifies ainvestigating the structural and functional relationshipphysical signal sensed by kinetochores (attachment of

between the signaling elements (e.g., membrane

the spindle and/or tension) and regulates the timing

receptors and transcription factors) and their targetsof the sister chromatid separation. Mad2, a signal(e.g., specific enzymes and DNA). The current projects

carrier of this feedback, plays a vital role in the spindle

deal with (1) higher-order architectures of prokaryotic

checkpoint. It is specifically localized at unattachedand eukaryotic chromosomes, (2) transcriptional

kinetochores that are the origin of the checkpoint

regulation in the context of chromatin structure, (3)signal. Mad2 targets CDC20 and inhibits its activity to

cross-talk between nuclear matrix and chromatin, andpromote sister chromatid separation. We study Mad2,(4) molecular mechanism of macromolecular transport

a central player of the spindle checkpoint, to reveal

between cytoplasm and nucleus via nuclear poremechanisms, which regulate the activity of Mad2.

complex. The approaches to these problems include
single-molecule imaging and force measurement
using scanning probe microscopy, as well as generalbiochemistry and molecular biological techniques. This
consolidation should reveal a large part of the overall
picture of regulation of cell signaling in eukaryotes
and prokaryotes.

Web Site http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index.htm
Web Site http://www.lif.kyoto-u.ac.jp/labs/chrom/

18

DIVISION OF INTEGRATED LIFE SCIENCE

Laboratory of Nanobiology

Laboratory of Developmental
Neurobiology■ Professor■ Associate Professor

HARADA, Yoshie■ Main theme

KENGAKU, Mineko■ Main theme

We are investigating single-molecule dynamic

Neurons in the mammalian brain are orderly

processes of DNA-protein interactions in DNA

arranged in cortices and nuclei for integration into

replication, repair and recombination which are thespecific neural circuits. During development, neurons

most essential for cellular metabolism by developing

directionally migrate from the birthplace to theirnovel single-molecule microscopy. This technology

destination within the cortex, and then arborize

enables us to perform studies by direct visualization

well-patterned dendrites and axons to contactof single protein localization and displacementwith their specific synaptic counterparts. The majoralong single DNA that is mechanically manipulated.

goal of our research is to clarity the mechanisms ofThis requires ultra high precision and sensitivity. In

cortical lamination and functional wiring of neurons

achieving this goal our understanding of fundamental

in the brain. We seek to identify the molecularbiological functions and the several tens of nm-

signals regulating neuronal migration and dendrite

sized "mesoscopic" world is promoted, and ultimately

p a t t e r n i n g . We a l s o a i m t o d e v e l o p i m a g i n g

attracts attention of a great interdisciplinary nature.

techniques for real-time observation of molecular andcellular dynamics of neuronal migration and dendrite
patterning to discover novel phenomena and rules inneuronal motility in the developing brain.

Web Site http://www.kengaku.icems.kyoto-u.ac.jp/

Web site http://www.harada.icems.kyoto-u.ac.jp/en/
index.html

DIVISION OF INTEGRATED LIFE SCIENCE

19

Division of Integrated
Life Science
Department of Molecular and Cellularr Biology
D

Laboratory of Molecular Cell Biology

Laboratory of Mammalian Molecular
Biology■ Professor■ Associate Professor■ Professor■ Associate Professor■ Instructor

FUJITA, Takashi
KATO, Hiroki■ Main theme

SHINKAI, Yoichi
TACHIBANA, Makoto
MURAKAMI, Akira■ Main theme

Virus infections, such as influenza A epidemic andOur principal objective is to understand theChronic Hepatitis C virus infection are still important

molecular mechanism of epigenetic gene regulationdiseases and outbreaks of newly emerging viruses are

and roles of epigenetics in health and disease. We

serious problems for modern society. Higher animals,

also study how germ-lineage cell development inincluding humans, are genetically equipped withmammals is regulated. To address above questions,mechanisms, collectively known as innate immunity,

we transgenic and gene-targeting technology.

to counteract viral infections. During the course of
replication, many viruses generate double-stranded(ds)RNA, which is virtually absent in normal cells andlikely serves as a "foreign molecule" in cells. An RNA
helicase, RIG-I, functions as a sensor for viral dsRNA. RIG-I
is composed of three domains : a Caspase recruitment
domain (CARD), a DExD/H helicase domain, and a
C-terminal domain (CTD)(Figure). CTD senses viral dsRNA
produced in the cytoplasm, leading to a conformationalchange. This conformational change releases CARD,
which signals to downstream, resulting in the activationof genes including those for type I interferon andenzymes that block viral replication. Bottom: Molecularmodeling of dsRNA recognition by CTD of RIG-I.
The purpose of our project is to clarify themolecular mechanism underlying the antiviral innate
immunity regulated by RIG-I, and to develop new
diagnostic and therapeutic tools for viral infections.

Web Site http://www.virus.kyoto-u.ac.jp/Lab/bunshiiden/index.html

20

DIVISION OF INTEGRATED LIFE SCIENCEWeb Site http://www.virus.kyoto-u.ac.jp/Lab/
mousemodel.htm

DIVISION OF SYSTEMIC LIFE SCIENCEThis division consists of 14 laboratories including 5 cooperative laboratories from Institute for Virus Research, Graduate School of Medicine,
Osaka Bioscience Institute, and RIKEN Center for Development Biology.
Thirty-eight graduate students are accepted in the Master's Program annually, and 16 in the Doctoral Program. In this division, education andresearch are focused on the elucidation of the fundamentals of molecular and systemic biology, cell biology and immunology. Experimental
approaches are taken with viruses, microorganisms, cultured cells andanimals. We pursue education and research to elucidate the molecular
aspects of Systemic Life Science.

Division of SystemicLife Science
Department of Molecular and Sy
Dystem BiologyyLaboratory of Neuroscience

Laboratory of Bioimaging andCell Signaling■ Professor■ Associate Professor■ Instructor■ Professor■ Lecturer■ Instructor

WATANABE, Dai
MORIYOSHI, Koki
ABE, Kentaro■ Main theme

MATSUDA, Michiyuki
AOKI, Kazuhiro
HIRATA, Eishu■ Main theme

Research in this laboratory deals with molecular

We are visualizing the growth signal transduction

mechanisms underlying brain function andcascades in living cells by using probes based on thedysfunction. The main theme of research is the study

principle of Foerster resonance energy transfer (FRET).

of synaptic mechanisms responsible for memory and

These FRET videos are processed to extract parameters

learning, motor movement and sensory perception.

that characterize the property of each signaling

The regulation and function of neurotransmittermolecule. We use these parameters obtained in living

receptors and ion channels in synaptic transmission

cells to build kinetic simulation models of growth signal

and integration are extensively studied.

transduction cascades.

Web site http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/index.htm

Web site http://www.phy.med.kyoto-u.ac.jp/

22

DIVISION OF SYSTEMIC LIFE SCIENCEDepartment of Animal Developpmennt
and Physiology

Laboratory of Immunology andCell Biology

Laboratory of Molecular andCellular Biology■ Professor■ Professor■ Associate Professor■ Instructor

MINATO, Nagahiro■ Main theme

YONEHARA, Shin
SAKAMAKI, Kazuhiro
LEE, Kyung-Kwon■ Main theme

The research activities in this laboratory are focused

Apoptosis, or programmed cell death, plays anon the understanding of the fundamental molecularimportant role in many biological processes, including

and cellular mechanisms of the development

embryogenesis, development of immune system,of immune system, modes of the immunologicalmaintenance of tissue homeostasis, and elimination

recognition, and the generation of immunologicalof virus-infected and tumor cells. We found cell

memory. For the purpose, a wide range of projects

surface Fas antigen (Fas), which can directly mediate

are currently studied from the molecular aspects suchapoptosis-inducing signals into cells by stimulation withas signal transduction in the lymphocyte activation toagonistic anti-Fas mAbs or Fas ligand (Yonehara S, etthe regulation of immune responses in the individualsal., 1989; Itoh N, et al., 1991). Our main research projectusing various gene-manipulated animals. Based on theis to understand the intracellular signal transduction

understanding of these fundamental immunologicalmechanism of cell death including apoptosis andphenomena and by applying all possible modern

caspase-independent novel types of cell death,biological techniques, the ideal manipulations

and the biological significance/physiological role ofare sought for tumor immunity, infection immunity,cell death and cell death-regulating molecules. In

transplantation immunity as well as autoimmunity to

conjunction with these studies, we have been trying tocontribute to the ultimate human health.

identify other cell death-related molecules that playa key role in embryogenesis, tumorigenesis or immune
system. Investigations of molecular mechanisms andphysiological roles of cell death and its related molecules
are important for a better understanding of mammalianembryogenesis, tumorigenesis and immune system.

Web site http://www.lif.kyoto-u.ac.jp/labs/Fas/

DIVISION OF SYSTEMIC LIFE SCIENCE

23

Division of SystemicLife Science

Laboratory of Immunobiology

Laboratory of Molecular Cell Biology■ Professor■ Lecturer■ Instructor（Matsuzaki Laboratory）
MATSUZAKI, Fumio■ Professor

INABA, Kayo
TAKAHARA, Kazuhiko
IYODA, Tomonori■ Main theme■ Main theme

Our interest is the induction and control of

We seek to explore the molecular mechanisms

immunity and tolerance. We focus on dendritic cells

underlying the organization of cells into highly ordered(DCs), which are a primary antigen-presenting cell in

structures in the developing brain. The vertebrate

the immune system. Studies have been conducted

brain comprises a considerably larger number ofat three levels: antigen uptake and presentation,neurons arranged in a vastly complex functionalsurface molecules and cytokines that mediate cell-

network, which develops from a single layer ofcell interactions, and pathways for function in vivo.

epithelial cells that function as neural stem cells.

Our current major topics include the development ofThose cells initially proliferate to expand the stem cellDCs from precursor cells, control of differentiation andpopulation. Subsequently neural stem cells undergo

maturation of DCs, antigen handling mechanisms,

asymmetric cell divisions to generate self-renewing

migratory characteristics from blood stream throughand differentiating daughter cells. Thus the transition

peripheral tissues to T area of lymphoid organs, andfrom the proliferative phase to the neurogenic

activation of antigen-specific CD4 and CD8 T cells.

phase is critical for the determination of the brain

DCs have been applied clinically in immunotherapy

size. Asymmetric cell division also appears to play an

as nature's adjuvant to induce and amplify immune

essential role in the neuronal production. However,

responses. For better vaccine design, control of DC

little is known about mechanisms controlling thosefunction using molecular techniques to introduce

critical events in the brain development.

functional genes and molecules are also conducted.

We use both an invertebrate (Drosophila) andvertebrate (mouse) model systems to understandprinciples for the brain organization such as:
1. How the timing of the proliferative to neurogenictransition is determined in the brain development.
2. How neural stem cells simultaneously generate
self-renewing and differentiating cells.
3. H o w c e l l p o l a r i t y c o n t r i b u t e s t o c o n t r o lasymmetric cell division of neural stem cells.
4. How diverse neuronal types are generated froma single neural stem cell over time.
5. How the global brain architecture is dictated by
the structure and activity of neural stem cells

Web site http://zoo.zool.kyoto-u.ac.jp/imm/

24

DIVISION OF SYSTEMIC LIFE SCIENCE

Web site http://www.cdb.riken.jp/en/02_research/0201_core07.html

（Imai Laboratory）■ Associate Professor

IMAI, Takeshi■ Main theme（Funabiki Laboratory）■ Associate Professor FUNABIKI, Kazuo■ Main theme

Neural circuit formation in vertebrates depends on

We analyze neural circuits related to the reflexive

peripheral inputs to a certain extent. We are studying

eye movements in mice. Reflexive eye movements are

how the neural circuits are constructed from peripherygood models to study neural mechanisms for motor

to the central nervous system in a hierarchical manner.

control and learning, because the inputs (vestibular,

We focus on the mouse olfactory system as a modelvisual stimuli) are precisely controlled and the outputs

system. We are particularly interested in how the odorant(eye movements) are quantitatively measured. In thereceptor control axonal projection of olfactory sensory

neural circuits related to reflexive eye movements, weneurons and how the peripheral inputs instruct specificfocus on the cerebellar flocculus and the vestibular

neuronal circuits in the olfactory bulb. We are also trying

nucleus. We record Purkinje cell response of thethe single-cell transcriptome analyses, in vivo imaging,

cerebellar flocculus in alert mice with simultaneousand novel genetic tools to approach these issues.

recording of eye movements. Recently we developed

Axonal projection of olfactory sensory neurons to
the olfactory bulb.

a fluorescence micro-endoscope which can observe
spatio-temporal pattern of neural activities in vivo. We
apply this endoscope for the analysis of cerebellar
granular layers in alert mice to elucidate neuralmechanisms for motor control and learning.

Web site http://imai.uijin.com/english.html

Web site http://www.obi.or.jp/japanese/introduction/
set_systemsbiology.html

DIVISION OF SYSTEMIC LIFE SCIENCE

25

Division of SystemicLife Science
Department of Signal Transductiions
D

Laboratory of Molecular Neurobiology

Laboratory of Membrane Biochemistry
and Biophysics■ Professor■ Associate Professor■ Instructor■ Professor■ Associate Professor■ Instructor

NEGISHI, Manabu
KATOH, Hironori
OINUMA, Izumi■ Main theme
Outline of Teaching Activities
The laboratory provides seminars which review anddiscuss recent progress in molecular mechanisms ofneuronal functions
Outline of Research Activities
The main themes of research in this laboratory

KOZUTSUMI, Yasunori
TAKEMATSU, Hiromu
NAITO, Yuko

■ Main theme
Research in this Laboratory focuses on the
biological function of membrane lipids andcarbohydrate.
Outline of Research Activities are as follows:(1) Sphingolipid-mediated signal transduction in
mammals and yeasts

are the molecular mechanisms underlying neuronal(2) Pathophysiological study on multinucleatednetwork formation and neuronal signal transductions.

cell formation in brains of patients of Krabbe's

1. Neuronal functions and signal transductions of
GTP-binding proteins
2. Molecular mechanisms for axon guidance
3. Regulatory systems of synaptic transmission
4. Signal transduction of neuronal polarity formationdisease, one of sphingolipid-related disorders.
(3) Molecular biological studies on the sialic acidconverting enzyme and its function using
knockout mice(4) Study on responsible genes for glyco-chain
expression using DNA microarray and corelation analysis

Web site http://www.lif.kyoto-u.ac.jp/labs/negishi/
index-e.html

26

DIVISION OF SYSTEMIC LIFE SCIENCE

Web site http://www.lif.kyoto-u.ac.jp/labs/kozutsumi/Department of Functional Biology

Department of Biostudies and Society

Laboratory of Functional Biology

Laboratory of Science Communication
and Bioethics■ Professor■ Lecturer■ Instructor■ Associate Professor

KAKIZUKA, Akira
HORI, Seiji
OHIZUMI, Hiroshi■ Main theme

KATO, Kazuto■ Main theme

The major experimental themes being analyzed

In our laboratory, we aim to identify essential issues

in our laboratory are the following: (1) The molecularin the interface between biostudies and the society,and biochemical basis of cell deathand to propose possible actions or solutions.

The aim of this research is to understand themolecular mechanisms underlying carcinogenesis andneurodegeneration and to develop new strategies
for the treatment of cancers and neurodegenerative
disorders.

Currently, we are focusing on the following threeareas.
1. Theoretical and practical analysis of science
communication.
In addition to organizing practical activities(2) The molecular basis of gene expression

such as "Genome Square", a public event (http://

networks determining energy expenditure and obesity

hiroba.genome-sci.jp/ in Japanese language

One of the main features of life science researchonly), we analyze the effects and significancein the coming years will be that the results obtainedof science communication. This includes thefrom fundamental research should ideally be

communication between scientists and the

directly connected to thegood of society. From thisgeneral public, and that among scientists andstandpoint, in addition to handling topics with highscientific significance, we aim to contribute to thedevelopment of treatments for neurodegenerative
diseases and cancers from our research results.
We hold the same view on scientific education,and through training individuals to communicate theirscientific communities.
2. Analysis of bioethical issues in biostudies.
We study ethical, legal and social implicationsof biostudies such as human genome researchand human stem cell research.
3. Analysis of modern history of biostudies.

ideas logically yet effectively, as well as by nurturing

We analyze the development and changes

their creativity, in addition to strengthening theirof biostudies in the last 20 to 30 years throughpractical research skills, we aim to cultivate opinion

literature surveys and interviews with scientists.

leaders standing at the core of life science research inthe 21st century.

Web site http://www.lif.kyoto-u.ac.jp/labs/funcbiol/

Web site http://www.zinbun.kyoto-u.ac.jp/~kato/

DIVISION OF SYSTEMIC LIFE SCIENCE

27

Division of SystemicLife Science
Department of Mammalian Reg
Dgulatoryy Netwoork

Laboratory of Cell Regulation and
Molecular Network

Laboratory of Viral Oncology■ Professor■ Associate Professor■ Associate Professor

SUGITA, Masahiko
MATSUNAGA, Isamu■ Main theme

HIJIKATA, Makoto■ Main theme

Full attention of the recently set up Sugita’s

The main purpose of this laboratory is to clarify thelaboratory has been directed to a novel lineage

molecular mechanisms of tumorgenesis caused by theof antigen-presenting molecules, CD1. Unlike

infection of human tumor viruses, specifically hepatitis

conventional MHC molecules that present protein-

C virus. Molecular and cellular biological analyses ofderived peptide antigens, molecules of thethe viral life cycle and effects of viral infection on thehuman group 1 CD1 family (CD1a, CD1b, CD1c)cell proliferation are under investigation.

mediate presentation of lipid antigens to specific
T lymphocytes. By taking cell biological andimmunological approaches, this group wishes toestablish a molecular and cellular basis for CD1dependent immunity and determine how CD1 has
been evolved to function critically in host defense.
An important extension of this study is a challenge
for developing a new type of lipid-based vaccines
against cancer and microbial infection.

Web site http://www.virus.kyoto-u.ac.jp/Lab/
SugitaLab.html
Web site http://www.virus.kyoto-u.ac.jp/virus/
ganvirus.html

28

DIVISION OF SYSTEMIC LIFE SCIENCE

Laboratory of Cell Division and
Differentiation

Laboratory of Genetic Information■ Professor■ Instructor■ Professor

TOYOSHIMA, Fumiko
MATSUMURA, Shigeru■ Main theme

SHIMIZU, Akira■ Main theme

The orientation of mitotic spindles, which

Major goal of research in this laboratory is todeter mines the plane of cell division, is tightly

understand molecular and cellular mechanisms

regulated in many types of the cells and plays aunderlying highly systemic functions of living things,

critical role in cell differentiation, embryogenesis

such as immune and neural systems. For this purpose,and organogenesis. Our group seeks to explore thestructure and regulation of genetic information

molecular mechanisms underlying the determination

responsible for such systemic functions are beingof cell division axis in both culture cells and inanalyzed using model animals, for example,

developing tissues. Our research is focused on thetransgenic or gene disrupted mice. Our research isfollowing subjects:

focused on the following subjects:

1. Genome-wide analysis of kinases required forspindle orientation control.
2. Dynamics of vesicle transport during mitosis.

1. A n a l y s i s o f m o l e c u l a r m e c h a n i s m s a n dregulation of chromatin modification, gene
expression, gene rearrangements and RNA
processing during lymphocyte differentiation.
2. Making and characterization of model miceof immunodeficiency or autoimmune byintroduction of, or targeted disruption ofinterleukin, immunoglobulin or other genes.
3. Analysis of molecular and cellular mechanism for
lymphocyte mobility and formation of immunomicroenvironment during development andimmune reaction.

Web site http://www.virus.kyoto-u.ac.jp/Lab/
toyoshima.html

DIVISION OF SYSTEMIC LIFE SCIENCE

29

Map & AccessGetting to Kyoto University

URL: http://www.kyoto-u.ac.jp/en/access/getting/getting_1.hhtm

1Faculty of Medicine Campus /Faculty of Pharmaceutical Science Campus

30

Map & Access

2

2

1

North Campus

3

3
Main Campus

Map & Access

31

Contact
Inquiries concerning entrance examination and"Global Frontier in Life Science"
Telephone number+81-75-753-9222

FAX number+81-75-753-9229

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

E-mail address

gakumu@adm.lif.kyoto-u.ac.jp

URL

http://www.lif.kyoto-u.ac.jp/Global_frontier_in_life_science/index.html

Other inquiries
Administration office at Graduate School of Biostudies
Telephone number+81-75-753-9221

FAX number+81-75-753-9247

Postal address

Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501

URL

http://www.lif.kyoto-u.ac.jp/e/GRADUATE SCHOOL OF
BIOSTUDIES,
KYOTO UNIVERSITY

2010