Wheezing and shortness of breath are the main symptoms of bronchial asthma. Patients withAasthmatics showed increased superoxide generation from leuckocytes, as well as andincreased lipid peroxidation products, both of which indicateing increased oxidative stress.
Ascorbic acid is an important antioxidant which that directly neutralizes free radical,

Comment [A1]: The APA encourages the use of
unbiased language by avoiding language that may
equate a person with his or her condition, e.g.,diabetic, epileptic, schizophrenic, and asthmatic. As
such, it is preferable to use the phrase “patients withasthma.”thusradicals; therefore, it is continuously utilizedused to maintain thea redox state in the oflungs of inpatients with asthma. Hatch et al. suggested that ascorbic acid is the major
antioxidant substance present in the airway surface lining of the lungs, and may protects
against endogenous as well asand exogenous oxidants. Our present finding of a low ascorbic
acid level in wheezing children couldwith wheezing may be attributeddue to its normal
physiological function and, elevatedincreased utilization to overcome the continuousgeneration of oxidant radicals and also and to neutralize the exogenous oxidants. It has beensuggested thatTherefore, ascorbic acid deficiency may be either an underlying factor in thepathophysiology of asthma or a response to asthmatic airwaysairway inflammation. Ourfindings of low ascorbic acid levels in wheezing children with wheezing is are in agreementwith the earlier reports, wherein of researchers who attributed such kind of loweringthe
decrease in the plasma ascorbic acid level in plasma to its normal physiological functions,
i.e., its utilization including its roles in maintaining the maintenance ofbody’s defense
mechanism, tissue and in the integrity and, replacement, and healing process.processes oftissues. Destruction of the respiratory mucous membrane during common cold and theconsequent resulting reduction of the in the tissue ascorbic acid, level may further delay inthe healing of the mucous membrane surface, leading to prolonged symptoms of asthma. A
study reported shows that serum levels of antioxidant vitamins are decreased in the sera ofasthmatic patients with asthma, even during the asymptomatic periods of the disease, andAll material in this document is the intellectual property of Crimson Interactive Pvt. Ltd. The use of informationand content in this document in whole or in part is forbidden unless express permission has been given inwriting by Crimson Interactive Pvt. Ltd.

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Comment [A2]: To create an easy flow of ideas,transition words such as however, therefore,moreover, etc. can be used. This usage enhances
coherence of ideas in the paragraph and themanuscript on the whole. Note that at this instance,
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thus. Therefore, this decrease is does not completely totally dependent on the increasedoxidative stress, as reflected by lipid peroxidation products.

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