Immunotoxicology Specialty
Section Newsletter
Pre-SOT bulletin
President’s Message
2014-2015
Executive Committee
President
Dr. Danuta Herzyk
Vice President
Dr. Rafael Ponce
Vice President-Elect
Dr. Peyton Myers
Secretary-Treasurer
Dr. Haley Neff-LaFord
Past President
Dr. Gary Burleson

Senior Councilor
Dr. Jamie DeWitt
Junior Councilor
Dr. Cheryl Rockwell
Postdoc Representative
Dr. Ashwini Phadnis-Moghe
Student Representative
Aimee Hillegas

The ITSS Newsletter is published 3times/year (Summer, Fall, andWinter). If you would like to share an
item of interest with members of theITSS, please send it to theCommunications Committee Chair.
All comments on, or suggestions to,the newsletter are welcome.

Ashwini Phadnis-Moghephadnisa@msu.edu

March 2015

Dr. Danuta Herzyk
President, ImTox SS2014-2015

I hope that by now everyone has finalizedplanning for your participation in the 54th
Annual SOT Meeting in warm and sunny San
Diego! This year’s program is filled with a great
number of remarkable immunotoxicologysponsored sessions, scheduled over the 5 daysof our meeting.

I want to thank Rafael Ponce and the 2014-2015
Program Committee members for their hard work that resulted insuch a successful Immunotoxicology program. Also, I would like toacknowledge those ITSS members who will be presenting at themeeting in San Diego and encourage all ITSS members to support
our colleagues by your attendance and active discussions in their
sessions.
On a very special note, please join me in congratulating ourrenowned ITSS member Dr. Ian Kimber, who received the SOTDistinguished Toxicology Scholar Award and will deliver theAwardee’s Lecture on 25th March at 12:30 PM. Congratulations
Dr. Kimber!
Please plan to attend our ITSS Reception that will take place on
Tuesday evening 6PM-7:30PM in Room 29 A of theConvention Center. It is a great opportunity to cross paths withfriends and colleagues, to celebrate the accomplishments of ourmembers and to meet our young students and postdocs. Inaddition, winners of many of our ITSS awards will be announced
and celebrated at the reception. Please join us to honor thosewell-deserving awardees.
President’s Message……………………………………………………1Student Post-doctoral Committee Report …….........……....….…..2
ITSS-sponsored programs at SOT…….......………..…………….....3Announcements................................................................................4ITSS Membership Update.................................................................4Job Opportunities..............................................................................5
Recent Immunotoxicology Publications.........................................6
1Immunotoxicology Specialty SectionDuring the reception you will have a chance to meet our new officers for 20152016 and interact with a delegation from our partner organization - the Japanese Society of
Immunotoxicology (JSIT). Special treats this year will include presentations by two of ourdistinguished members – Dr. Jack Dean, who will share his thoughts on the 30-year history of
the ITSS, and Dr. Rodney Dietert, who will tell us about his unique adventure in making ascientific documentary film.
Students and Postdocs – don’t forget to check out information in the bulletin below about theMixer section and the new ITSS Mentor-Student/Postdoc event.
I look forward to seeing you all in San Diego.
Dr. Danuta Herzyk,President, ITSS (2014-2015)

Student & Postdoctoral Report
Submitted by Ashwini Phadnis-Moghe, PhD
SOT is right around the corner, and we hope you all have geared up to present yourresearch and participate in several activities and networking events! We hope that you areplanning to attend the continuing education courses on Saturday wherein you can expand yourknowledge in some of the hot areas of toxicology. One of the first events of interest for all
graduate students and postdocs is the Student/Postdoc mixer sponsored by the Graduate
Student Leadership Committee. It is FREE for all students and postdocs and will take place onSun, March 22nd, 7:30-9pm at the Conference Center Ballroom 20D. This is a great
opportunity to network and learn more about specialty sections and regional chapters.
Throughout the week, the Graduate Student Leadership Committee and Postdoctoral Assembly
will host a number of networking and educational events, including Chat with an Expert andPoster Tours. Both these events provide opportunities to meet with and learn from leading
experts in the toxicology field. Hope you have signed up for either or both the events.
The Postdoctoral Assembly Luncheon will take place on Tuesday, March 24th from noon1:15 pm at Conference Center Ballroom 5 . Lastly, there will be two big events forImmunotoxicology SS members on Tuesday, March 24th. The ITSS is organizing anetworking event for graduate students and postdocs wherein you can meet with a panel of
Immunotoxicologists working either in industry, academia, government or independent
consulting. This event will be held from 5:00-5:30pm just prior to the ITSS reception. No priorregistration is needed for this event. Just come and network! In addition to this, you will also beable to informally meet your fellow ITSS peers at the ITSS reception from 6:00-7:30pm atconference center Room 29A. Awards will be presented during the reception.Then,
immediately afterwards, please join us at the for the ITSS Student/Post
ITSS
Student/Postdoc Mixer will take place from 7:30- 9:00pm at the La Puerta restaurant.
Please join us and meet your fellow ITSS peers.
We hope you can join us for all these exciting events!
March 2015

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ITSS-SPONSORED SESSIONS TO LOOK FORWARD TO..

Roundtable
RDTB-04 Wed, 12- Should Respiratory Sensitizers Be Listed As Substances of
1:20
Very High Concern (SVHC) under REACH?

Continuing Education
AM06
PM11Sun, AM The New World of Cancer Immunotherapy: Challenges in
Bench to Bedside Translation.
Sun, PM Skeletal System Endocrinology and Toxicology

Workshop
WKSP-05 Tue, 1:30- Current Understanding of Immune-Mediated Adverse
4:15
Drug Reactions
Chairperson(s): Arno Siraki and Alison Harrill
WKSP-27 Wed,
Strengths and Weaknesses of Mouse Models in Studies
1:30-4:15 of Immunological Effects of Drugs and Chemicals
Chairperson(s): Courtney Sulentic and B. Nanduri

Symposia
SYM-07

SYM-09SYM-10March 2015

Thurs, Epigenetics, Developmental Programming, and Immune
9-11:45 Function: Where Do We Go from Here?
Chairperson(s): Berran Yucesoy and Victor Johnson
Tue, 9- Immune Responses to Different Classes of Inhaled
11:45 Particulates: Unique vs. Shared Responses andMechanisms
Chairperson(s): Andrij Holian and Seishiro HiranoMon, 2- Immunostimulant Cancer Treatments: Toxicology
4:45
Programs with an Autoimmmune “Twist”
Chairperson(s): Lauren Black and Helen Haggerty
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Immunotoxicology Specialty Section

ANNOUNCEMENTS!

ITSS MEMBERSHIP UPDATEMarch 2015

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Immunotoxicology Specialty Section

JOB OPPORTUNITIESThe National Institute for Occupational Safety and Health (NIOSH), Health Effects Laboratory
Division (HELD), located in Morgantown, West Virginia has an opening for a postdoctoral
fellow in the Hazard Identification and Immunotoxicology Team of the Allergy and Clinical
Immunology Branch. The focus of the lab is to identify occupational and environmental
chemical hazards by evaluating immune function using murine models. Extensive knowledge
about innate and adaptive immunity is desirable. The candidate should have a PhD in
immunology or a related field. A background in toxicology is preferred but not mandatory.
Excellent graduate training, good publication record, experience with in vivo mouse models isdesirable. Salary range starts at $57,982. CDC-NIOSH is an affirmative action/equal
opportunity employer.
Interested applicants should email their curriculum vitae, a statement of current and future
research interests and why you are interested in our research, and complete contact
information of three references to Sanderson4@cdc.gov.
Stacey Anderson, Ph.D.
Team Leader
Hazard Identification and Immunotoxicology Lab
1095 Willowdale Dr. M/S 4020
Morgantown, WV 26505

March 2015

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Recent Immunotoxicology Publications
Compiled by Haley Neff-LaFord

Anytime you have a new fully-published or electronically-available article to report, please
send the citation at any time to the coordinator, Haley Neff-LaFord: hnlaford@seagen.com
Asthma, Allergy, Autoimmunity & Hypersensitivity
Jayasena S, Smits M, Fiechter D, de Jong A, Nordlee J, Baumert J, Taylor SL, Pieters
RH, and Koppelman SJ. Comparison of Six Commercial ELISA Kits for Their Specificity andSensitivity in Detecting Different Major Peanut Allergens. J Agric Food Chem 63:1849-1855,
2015.
Stojadinovic M, Pieters R, Smit J, and Velickovic TC. Cross-linking of β-lactoglobulin enhances
allergic sensitization through changes in cellular uptake and processing. Toxicol Sci 140:224235, 2014.
van den Elsen LW, Bol-Schoenmakers M, van Esch BC, Hofman GA, van de Heijning BJ,Pieters RH, Smit JJ, Garssen J, and Willemsen LE. DHA-rich tuna oil effectively suppresses
allergic symptoms in mice allergic to whey or peanut. J Nutr 144:1970-1976, 2014.
Developmental Immunotoxicology
Ahrenhoerster LS, Leuthner LS, Tate ER, Lakatos PA, and Laiosa MD. Developmental
exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin attenuates later-life Notch1-mediated T cell
development and leukemogenesis. Toxicol Appl Pharmacol 283:99-108, 2015.
Zhang Y, Mikhaylova L, Kobzik L, and Fedulov AV. Estrogen-mediated impairment ofmacrophageal uptake of environmental TiO2 particles to explain inflammatory effect of TiO2 on
airways during pregnancy. J Immunotoxicol 12:81-91, 2015.
General Immunotoxicology
Altunkaynak BZ and Ozbek E. Histopathological effects of anthrax lethal factor on rat liver. JImmunotoxicol 12:33-39, 2015.
Antoine F and Girard D. Curcumin increases gelatinase activity in human neutrophils by a p38
mitogen-activated protein kinase (MAPK)-independent mechanism. J Immunotoxicol 12:188192, 2015.
Bahari A, Mehrzad J, Mahmoudi M, Bassami MR, and Dehghani H. GST-M1 is transcribed
moreso than AKR7A2 in AFB-1-exposed human monocytes and lymphocytes.
J
Immunotoxicol 12:194-198, 2015.

March 2015

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Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Ben Salah-Abbes J, Abbes S, Jebali R, Haous Z, and Oueslati R. Potential preventive role oflactic acid bacteria against Aflatoxin M1 immunotoxicity and genotoxicity in mice.
J
Immunotoxicol 12:107-114, 2015.
Ben Salah-Abbes J, Abbes S, Zohra H, and Oueslati R. Tunisian radish (Raphanus sativus)
extract prevents cadmium-induced immunotoxic and biochemical alterations in rats.
J
Immunotoxicol 12:40-47, 2015.
Boldenow E, Hassan I, Chames MC, Xi C, Loch-Caruso R. The trichloroethylene metabolite s(1,2-dichlorovinyl)-l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α inhuman extraplacental membranes in vitro. Reprod Toxicol doi: 10.1016/j.reprotox.2015.01.007,
2015.
Caniceiro BD, Latorre AO, Fukumasu H, Sanches DS, Haraguchi M, and Gorniak SL.
Immunosuppressive effects of Pteridium aquilinum enhance susceptibility to urethane-induced
lung carcinogenesis. J Immunotoxicol 12:74-80, 2015.
Cohen MD, Vaughan JM, Garrett B, Prophete C, Horton L, Sisco M, Kodavanti UP, Ward WO,Peltier RE, Zelikoff J, and Chen LC. Acute high-level exposure to WTC particles altersexpression of genes associated with oxidative stress and immune function in the lung. JImmunotoxicol 12:140-153, 2015.

Dattaroy D, Pourhoseini S, Das S, Alhasson F, Seth RK, Nagarkatti M, Michelotti GA, Diehl AM,and Chatterjee S. Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated
NADPH oxidase in experimental and human nonalcoholic steatosis. Am J Physiol Gastrointest
Liver Physiol 308:G298-312, 2015.
Dibazar SP, Fateh S, and Daneshmandi S. Immunomodulatory effects of clove (Syzygiumaromaticum) constituents on macrophages: In vitro evaluations of aqueous and ethanolic
components. J Immunotoxicol 12:124-131, 2015.
Djokic J, Aleksandrov AP, Ninkov M, Mirkov I, Zolotarevski L, Kataranovski D, and Kataranovski
M. Cadmium administration affects circulatory mononuclear cells in rats. J Immunotoxicol
12:115-123, 2015.
Gaida K, Salimi-Moosavi H, Subramanian R, Almon V, Knize A, Zhang M, Lin FF, Nguyen HQ,Zhou L, Sullivan JK, Wong M, and McBride HJ. Inhibition of CRAC with a human anti-ORAI1
monoclonal antibody inhibits T-cell-derived cytokine production but fails to inhibit a T-celldependent antibody response in the cynomolgus monkey. J Immunotoxicol 12:164-173, 2015
Lebrec H, Ponce R, Preston BD, Iles J, Born TL, and Hooper M. Tumor necrosis factor, tumor
necrosis factor inhibition, and cancer risk. Curr Med Res Opin 16:1-18, 2015.

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Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Malaviya R, Gow AJ, Francis M, Abramova EV, Laskin JD and Laskin DL. Surfactant protein
D and iNOS in radiation-induced lung damage. Toxicol Sci 144:27-38, 2015.
Mandarapu R and Prakhya BM. In vitro myelotoxic effects of cypermethrin and mancozeb on
human hematopoietic progenitor cells. J Immunotoxicol 12:48-55, 2015.
Mehrzad J, Devriendt B, Baert K, and Cox E. Aflatoxins of type B and G affect porcine
dendritic cell maturation in vitro. J Immunotoxicol 12:174-180, 2015.
Mishra S, Malhotra P, Gupta AK, Singh PK, Javed S, and Kumar R. A semiquinone glucosidederivative isolated from Bacillus sp. INM-1 provides protection against 5-fluorouracil-induced
immunotoxicity. J Immunotoxicol 12:56-63, 2015.
Mokgobu MI, Cholo MC, Anderson R, Steel HC, Motheo MP, Hlatshwayo TN, Tintinger GR,and Theron AJ. Oxidative induction of pro-inflammatory cytokine formation by humanmonocyte-derived macrophages following exposure to manganese in vitro. J Immunotoxicol
12:98-103, 2015.
Ng W, Metushi IG, and Uetrecht J. Hepatic effects of aminoglutethimide: A model aromaticamine. J Immunotoxicol 12:24-32, 2015.
Niu Y, Yu W, Fang S, Liu S, Yang Z, Liu W, Chen S, Yang L, Li B, and Li Y. Lead poisoning
influences TCR-related gene expression patterns in peripheral blood T-lymphocytes ofexposed workers. J Immunotoxicol 12:92-97, 2015.
Phadnis-Moghe AS, Crawford RB, and Kaminski NE. Suppression of human B cell activation
by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6.
Toxicol Sci 144:39-50, 2015.
Poole JA, Anderson L, Gleason AM, West WW, Romberger DJ, and Wyatt TA. Patternrecognition scavenger receptor A/CD204 regulates airway inflammatory homeostasis
following organic dust extract exposures. J Immunotoxicol 12:64-73, 2015.

Pourhoseini S, Seth RK, Das S, Dattaroy D, Kadiiska MB, Xie G, Michelotti GA, Nagarkatti M,Diehl AM, and Chatterjee S. Upregulation of miR21 and repression of Grh13 by leptin
mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis. PLoS
One doi: 10.1371/journal.pone.0116780, 2015.
Sakthivel KM and Guruvayoorappan C. Acacia ferruginea inhibits cyclophosphamide-induced
immunosuppression and urotoxicity by modulating cytokines in mice. J Immunotoxicol12:154-163, 2015.

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Recent Immunotoxicology Publications
Seth RK, Das S, Pourhoseini S, Dattaroy D, Igwe S, Ray JB, Fan D, Michelotti GA, Diehl AM,and Chatterjee S. M1 polarization bias and subsequent nonalcoholic steatohepatitis
progression is attenuated by nitric oxide donor DETA NONOate via inhibition of CYP2E1induced oxidative stress in obese mice. J Pharmacol Exp Ther 352:77-89, 2015.
Shahriary A, Mehrani H, Ghanei M, and Parvin S. Comparative proteome analysis ofperipheral neutrophils from sulfur mustard-exposed and COPD patients. J Immunotoxicol
12:132-139, 2015.
Shahzad A, Khan A, Khan MZ, Mahmood F, Gul ST, and Saleemi MK. Immuno-pathologic
effects of oral administration of chlorpyrifos in broiler chicks. J Immunotoxicol 12:16-23, 2015.

Steenhof M, Janssen NA, Strak M, Hoek G, Gosens I, Mudway IS, Kelly FJ, Harrison RM,Pieters RH, Cassee FR, and Brunekreef B. Air pollution exposure affects circulating whiteblood cell counts in healthy subjects: the role of particle composition, oxidative potential andgaseous pollutants - the RAPTES project. Inhal Toxicol 26:141-165, 2014.
Tewari P, Roy R, Mishra S, Mandal P, Yadav A, Chaudhari BP, Chaturvedi RK, Dwivedi PD,
Tripathi A, and Das M. Benzanthrone induced immunotoxicity via oxidative stress andinflammatory mediators in Balb/c mice. Immunobiol 220:323-436, 2015.
Tooker BC, Brindley SM, Chiarappa-Zucca ML, Turteltaub KW, and Newman LS. Accelerator
mass spectrometry detection of beryllium ions in the antigen processing and presentation
pathway. J Immunotoxicol 12:181-187, 2015.
Methods/ModelsLebrec H, Molinier B, Boverhof D, Collinge M, Freebern W, Henson K, Mytych DT, Ochs HD,Wange R, Yang Y, Zhou L, Arrington J, Christin-Piche MS and Shenton J. The T-celldependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals:
study design, data analysis, interpretation. Regul Toxicol Pharmacol 69: 7-21, 2014.
Teunis MA, Spiekstra SW, Smits M, Adriaens E, Eltze T, Galbiati V, Krul C, Landsiedel R,Pieters R, Reinders J, Roggen E, Corsini E, Gibbs S. International ring trial of the epidermalequivalent sensitizer potency assay: reproducibility and predictive-capacity. ALTEX 31:251268, 2014.
Reviews/Books/Commentaries
Aligo J, Walker M, Bugelski P, and Weinstock D. Is murine gammaherpesvirs-68 (MHV-68) a
suitable immunotoxicology model for examining immunomodulatory drug-associated viral
recrudescence. J Immunotoxicol 12:1-15, 2015.

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Recent Immunotoxicology Publications
Burden N, Mahony C, Muller BP, Terry C, Westmoreland C, and Kimber I. Aligning the 3Rs
with new paradigms in the safety assessment of chemicals. Toxicology 330:41-43, 2015.
Ratajczak HV and Sothem RB. Seasonality of influences on disorders of psychologicaldevelopment: A synopsis. NAJ Med Sci 7:123-129, 2014.
Sun N, Zhou C, Zhou X, Sun L, and Che H. Use of a rat basophil leukemia (RBL) cell-based
immunological assay for allergen identification, clinical diagnosis of allergy, and identificationof anti-allergy agents for use in immunotherapy. J Immunotoxicol 12:199-205, 2015.

IMPORTANT DATES AND TIMES
54th Annual Society of Toxicology Meeting
March 22-26, 2014San Diego, California

Immunotoxicology Meeting/Reception
Tuesday, March 24
6:00-7:30pm
Room 29A of the San Diego Convention Center
Immunotoxicology Student/Postdoctoral mixer
Tuesday, March 24
7:30pm-9:00pm
La Puerta Restaurant, 560, 4th Avenue, San Diego.

March 2015

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