ImmunoTox Letter
English pages

Program (Tentative Schedule)■September 8, 2011 (Thursday)

Non-clinical allergenicity testing:current and future issues.

・Invited Plenary Lecture:
Dr. Robin L. Thurmond (J & J Pharm R & D, L.L.C.

Jun-ichi Sawada

Research Fellow)(Pharmaceuticals and Medical Devices Agency)

・Luncheon Seminar 1:
Dr. Geneviève Pinard (Charles River Laboratories

Summary

Preclinical Services Montréal

The current (and past) and future issues on non-clinical

Inc.CANADA)

allergenicity testing methods in Japan were outlined and・Award Lectures:

discussed under the following subtitles: (1) introduction,

Prof. Takemi Yoshida Dr. Ryosuke Nakamura(2) delayed-type chemical allergy (skin sensitization tests),・Symposium:(3) immediate-type chemical allergy, (4) allergenicity for「Food Allergy- From in vitro prediction test to

food additives, (5) allergenicity of food proteins (foodclinical test -」allergy), (6) immunogenicity of therapeutic proteins, andDr. Hiroshi Ohno (RIKEN Yokohama Institute)(7) conclusion. Most of non-clinical methods are still

Dr. Haruyo Nakajima Adachi (The University ofinsufficient, and therefore final allergenicity assessmentsTokyo)

usually await human epidemiological data. For aDr. Yasuto Kondo (Fujita Health University)

substance which has potential allergenicity, case-by-caserisk-benefit analysis prior to its marketing and careful
post-marketing risk management will be needed.

Dr. Gregory Ladics (Du Pont Ag Biotechnology, USA)・Invited Special Lecture:
Prof. Chisato Mori (Dept. of Bioenvironmental
Medicine, Graduate School of Medicine,ChibaUniversity)

The 18th Annual Meeting of JapaneseSociety of Immunotoxicology (JSIT 2011)

・Oral/Poster presentation
・Social gathering:
KEYAKI-kaikan (3rd floor, Banquet room)

September 8-9, 2011
KEYAKI-kaikan (University Hall), Chiba University■September 9, 2011 (Friday)(Nishi-Chiba campus)

・Educational Lecture:

1-33 Yayoi-cho, Inage-ku Chiba, 263-8522 Japan

Dr. Nahoko Kaniwa (Division of Medicinal Safety

Organizing Committee of the 18th Annual Meeting ofScience, NIHS)
・Luncheon Seminar 2:

JSIT
http://jsit18.umin.ne.jp

Dr. Christopher Kirton (Huntingdon Life Sciences

President:Koichi Ueno, Graduate School ofLtd., UK)

Pharmaceutical Sciences, Chiba University

・Workshop:

Secretary-general: Katsunori Yamaura, Graduate「M e t h o d s o f A s s e s s m e n t f o r D e v e l o p m e n t a l

School of Pharmaceutical Sciences, Chiba UniversityImmunotoxicity」

P h o n e : +81-43-226-2878

Dr. Gregory Ladics (Du Pont Ag Biotechnology, USA)FA X : +81-43-226-2879

Dr. Wataru Watanabe (Kyushu University of Healthe-mail: jsit18-office@umin.ac.jp

and Welfare)
Deadline for abstract submissions: June 27, 2011

Dr. T in T in W in Shwe (National Institute for

The theme for this Meeting: Crosstalk betweenEnvironmental Studies)clinical and experimental immunotoxicology

Dr. Koichi Hayashi (The Institute of Environmental─ 14 ─Vol. 16 No. 1 (2011)

Toxicology)
・Oral presentation Poster discussion
・Awards Ceremony

シリーズ
Young powerfor immunotoxicological research9「免疫毒性研究の若い力」

From chromatin to Immunotoxicology
Masamitsu Eitoku(Department of Environmental Medicine, Kochi Medical School, Japan)

The aim of my graduate studies was to understandmulti role of histone chaperone CIA which would
be the key factor in chromatin structural change invarious nuclear reaction such as transcription, DNAreplication, and DNA repair. I supposed that CIA used
its different molecular surfaces for interactions withvarious factors in each reaction to play several roles.
So, I produced 90 yeast point mutant strains expressing
CIA mutant proteins, which had point mutations in theamino acids located on CIA molecular surface. Then, I
performed phenotypic analyses related transcription,
DNA replication, and DNA repair. These results wereconsistent with the results of two kinds of structural
analyses performed by my coworkers. One structure
was the complex structure of CIA, histone H3 and H4,and the other was the complex structure of CIA andbromodomain of general transcription factor TFIID.
Bromodomain was known to recognize acetylated
histone, which was famous as one of the epigenetic
information in transcriptionally active region. We
published two papers getting together these functionaland structural results. In these papers, we could succeed
to show some models about the molecular mechanism ofnucleosome assembly and disassembly, semi-conservative
nucleosome replication, and transcription initiation withchromatin template. In the field of immunotoxicology, I
am now challenging to show the relationship of epigenetic
regulation and lung inflammation caused by exposure to
toxic metal fume.

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