水素分子の各種疾患又は疾患モデルに対する効果を報告した文献
2021.6.25 現在 Ver. 3.1
対象器官疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
脳

脳梗塞

Ohsawa et al, 2007; Ono et al, 2011; Ji

細胞

齧歯類

○

○

その他動物

投与形態
ヒト

培養液 生食

○

○

水

○

ガス

その他

○

et al, 2011; Liu et al, 2011b; Cui et al,2014; Zhao et al, 2015; Ono et al, 2017
脳における活性酸素産生

Sato et al, 2008○○

拘束で誘発した認知障害

Nagata et al, 2009○○

脳虚血で誘発した認知障害

Ge et al, 2012○

敗血症で誘発した認知障害

Zhou et al, 2012a; Liu et al, 2015;

○

○

○

○
○

Jiang et al, 2020; Yu et al, 2021
肝切除で誘発した認知障害

Tian et al, 2016○

低酸素誘発認知障害

Li et al, 2018〇

外傷性脳傷害で誘発した認知欠

Hou et al, 2012○

認知障害改善効果の性差

Hou et al, 2018〇

アルツハイマー病

Li et al, 2010; Wang et al, 2011a; Ono

○

〇
○

損

〇
〇

○

〇

et al, 2018; Zhang et al, 2019
老化促進マウスにおける老年性

Gu et al, 2010○

Chen et al, 2010b

○

○

認知障害
出血性梗塞

1

○

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
脳

細胞
脳内出血

齧歯類

Manaenko et al, 2011; Manaenko et

その他動物

投与形態
ヒト

培養液 生食

水

ガス

○

○

al, 2013; Choi et al, 2018
パーキンソン病

Fu et al, 2009; Fujita et al, 2009; Ito et
al,

2012;

Yoritaka

et

al,

○

○

〇

○

○

2013;

Matsumoto et al, 2013; Yoshii et al,
2017; Noda et al, 2019; Zhang et al,2021; Hong et al, 2021
脳外傷

Ji et al, 2010○

外傷性脳障害Ji et al, 2012; Yuan et al, 2015; Liu et

○

○

○

○

○
○

〇

al, 2017; Fu et al, 2018; Yuan et al,
2018; Zhou et al, 2020
CO 中毒

Sun et al, 2011b; Wang et al, 2012a;
Wang et al, 2012c; Shen et al, 2013

一過性で広範な脳虚血

Hugyecz et al, 2011○○

頸動脈の結紮による脳虚血

Nagatani et al, 2012○○

くも膜下出血における脳障害

Zhan et al, 2012; Zhuang et al, 2012;

○

○

○

Zhuang et al, 2013; Hong et al, 2014;
Shao et al, 2015; Kumagai et al, 2020;
Zhang et al, 2021
くも膜下出血における脳血管攣

Hong et al, 2012

○

縮

2

その他

○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
脳

細胞

齧歯類

その他動物

Shen et al, 2011○

外科的に誘発した脳障害

Eckermann et al, 2011; Xin et al, 2017○

脳血管結紮で誘発した脳虚血

Li et al, 2012c

LPS で誘発した神経炎症と疾病

Spulber et al, 2012

海馬の循環停止で誘発した脳傷

投与形態
ヒト

培養液 生食

水

ガス

その他

○

害
○

○
○

○

○

○

○

○

行動
両側総頸動脈結紮による脳障害

Nagatani et al, 2013○○

心肺バイパスによる脳障害

Chen et al, 2017○○

心停止蘇生後の脳障害

Huo et al, 2014; Cole et al, 2019○

外傷性脳障害で誘発した神経変Dohi et al, 2014○○

Wang et al, 2014○○

脳卒中における神経学的症状

Takeuchi et al, 2015

○

○

脳虚血傷害

Han et al, 2015○○

低酸素/再酸素化誘発細胞死

Wei et al, 2015

ALS

Zhang et al, 2015○

自己免疫性脳脊髄炎

Zhao et al, 2016; Liu et al, 2018○

うつGao et al, 2017

○

〇

○

〇

性
クロルピリホスで誘発した神経
毒性

○

3

○
○
○
○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
脳

細胞
脳虚血再灌流障害

Cui et al, 2016; Li et al, 2016; Gao et

齧歯類

その他動物

投与形態
ヒト

培養液 生食

○

水

○

ガス

その他

○

al, 2017; Wang et al, 2017; Wu et al,
2018; Huang et al, 2018; Chen et al,
2019; Huang et al, 2019
うつ様行動

Zhang et al, 2016○○

外傷性脳傷害後の脳障害と炎症

Tian et al, 2016○○

低酸素虚血性脳疾患

Nemeth et al, 2016

イソフルラン誘発認知障害

Li et al, 2017

不安様行動

Wen et al, 2017; Masuda et al, 2017〇

認知症

Lang et al, 2017; Nishimaki et al,

○

〇
〇

〇

〇

〇

〇
〇

○

○

○

2017
海馬に対する酸化ストレス

Paulis et al, 2018○

脳虚血再灌流後の神経学的アウ

Huang et al, 2018○

血管性認知症

Jiang et al, 2018○

爆風由来脳障害

Satoh et al, 2018○

自閉症様行動異常

Guo et al, 2018○

CO 誘発脳障害

Xu et al, 2019○

パーキンソン病における腸内細Suzuki et al, 2019

〇
〇

トカム

〇

菌の水素産生

4

〇
〇
〇
〇
〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
脳

細胞
脳卒中モデルにおけるマクロフ

Ning et al, 2018

齧歯類

その他動物

投与形態
ヒト

〇

培養液 生食水ガス〇

ァージとミクログリアの分極
パーキンソン病における尿中 8-Hirayama et al, 2018

〇

精神的疲労

Mikami et al, 2019〇

心停止で誘発した認知欠損

Huang et al, 2019〇

放射線誘発認知機能障害

Liu et al, 2019〇

運動負荷による海馬の炎症

Nogueira et al, 2019〇〇

敗血症誘発記憶喪失

Jesus et al, 2020〇〇

敗血症誘発脳症

Zhuang et al, 2020〇〇

くも膜下出血後の内皮障害

Zhuang et al, 2020〇〇

糖尿病における外傷性脳障害

Li et al, 2020〇〇

肺がんの脳転移Chen et al, 2019

敗血症誘発脳障害

Xie et al, 2020a; Xie et al, 2020b

認知機能障害Korovljev et al, 2020

脊髄傷害

Chen et al, 2010a; Wang et al, 2015;〇

OHdG 産生

神経/脊髄

〇
〇
〇

〇

〇

〇

〇
〇

○

〇
○

〇

○

○

Chen et al, 2018

脊髄の虚血再灌流障害

Huang et al, 2011b; Zhou et al, 2013

5

○

その他

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
神経/脊髄

細胞
神経因性疼痛Chen et al, 2013; Kawaguchi et al,

齧歯類

その他動物

投与形態
ヒト

培養液 生食

水

○

○

○

ガス

その他

2014; Ge et al, 2014; Chen et al,2015; Wang et al, 2018; Chen et al,
2019; Lian et al, 2021
アストログリア増殖症

Liu et al, 2014

レミフェンタニル誘発痛覚過敏

Zhang et al, 2014a; Shu et al, 2015○○

レミフェンタニル誘発高侵害受

Zhang et al, 2014b

○

○

〇

〇

○

〇

容作用

眼

神経細胞死

Kashiwagi et al, 2014

末梢神経の自己移植

Zhang et al, 2016

神経芽細胞死Murakami et al, 2017

ヘルペス後神経痛

Ma et al, 2017

自律神経機能Mizuno et al, 2018

メタンフェタミン誘発神経毒性

Wen et al, 2019〇

緑内障

Oharazawa et al, 2010○

アルカリで誘発した角膜腐食

Kubota et al, 2011; Cejka et al, 2017;

○

○

○
○

○

〇

〇
〇

〇

〇

〇
〇
○

〇

〇

Cejka et al 2020
網膜障害

Wei et al, 2012; Tian et al, 2013; Fenget al, 2012; Qi et al, 2015; Zhang et al,
2016

6

○

○

〇

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
眼

細胞
網膜ミクログリア細胞の LPS 誘

Liu et al, 2013

齧歯類

投与形態

その他動物

ヒト

○

培養液 生食

水

ガス

その他

○

発炎症
亜セレン酸誘発白内障

Yang et al, 2013○○

視神経クラッシュSun et al, 2014○○

網膜の虚血再灌流障害

Liu et al, 2015; Wang et al, 2016; Wu

○

○

○

et al, 2018
網膜の酸化ストレス

Yokota et al, 2015

光受容体変性Chen et al, 2016○

白内障手術時の角膜内皮障害

Igarashi et al, 2016; Igarashi et al,

○

○

○
○
〇

○

2019

耳

ドライアイ

Chu et al, 2017〇〇

エンドトキシン誘発ぶどう膜炎

Yan et al, 2017; Yan et al, 2018〇〇

網膜色素変性症

Yan et al, 2017

○

○

網膜変性症

Tao et al, 2017

○

角膜光損傷

Cejka et al, 2017a○

紫外線誘発角膜障害

Cejka et al, 2017b〇

網膜静脈閉塞Long et al, 2019

〇

網膜の老化

Li et al, 2019

〇

聴覚障害

Kikkawa et al, 2009; Taura et al, 2010;
Lin et al, 2011

7

○

○

〇

○
○

〇
〇
〇
○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
耳

細胞

齧歯類

ウアバイン誘発聴器神経障害

Qu et al, 2012a○

騒音で誘発した聴覚消失

Zhou et al, 2012b; Kurioka et al, 2014;

○

その他動物

投与形態
ヒト

培養液 生食

水

ガス
○

○

○

Chen et al, 2014; Fransson et al, 2021

肺シスプラチン誘発聴器毒性Qu et al, 2012b; Kikkawa et al, 2014;

聴覚毒性

Frannson et al, 2017

○

虚血難聴

Ogawa et al, 2017

○

内耳障害

Pirttila et al, 2019〇

酸素誘発肺障害Sun et al, 2011c; Huang et al, 2010;

○

○

○

○

○
○
○
〇
○

○

Zheng et al, 2010; Huang et al, 2011a;
Kawamura et al, 2013
肺移植

Kawamura et al, 2010; Kawamura et

○

〇

○

al, 2012; Zhou et al, 2013; Haam etal, 018
パラコート誘発肺障害

Liu et al, 2011a; Li et al, 2020

放射線誘発肺障害

Terasaki et al, 2011; Chuai et al, 2011○○

火傷誘発肺障害

Qiu et al, 2010; Fang et al, 2011○○

腸の虚血再灌流傷害で誘発した

Mao et al, 2009

○

○

〇

肺障害

8

○

〇

○

その他

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
肺

LPS 誘発急性肺障害

Qiu et al, 2011; Xie et al, 2012a; Liang

細胞

齧歯類

〇

○

その他動物

投与形態
ヒト

培養液 生食

水

ガス

〇

〇

○

○

その他

et al, 2012; Liu et al, 2015; Zhang etal, 2015; Dong et al, 2017; Wang et al,
2019; Fu et al, 2020; Li et al, 2021
肺の虚血再灌流障害

Li et al, 2012b; Shi et al, 2012;

○

○

○

〇

Takahashi et al, 2017; Zhang et al,
2019; Kayawake et al, 2020
敗血症ショック誘発性の肺と腸Liu et al, 2013○

Shi et al, 2013; Du et al, 2014a; Moon

○

○

の障害
出血性ショック誘発性の肺障害○○

et al, 2019
心肺バイパスにおける炎症反応

Fujii et al, 2013○

慢性閉塞性肺疾患（COPD）

Ning et al, 2013; Liu et al, 2017; Liu

○

○
○

〇

et al, 2017; Lu et al, 2018
心臓死の後の肺灌流

Haam et al, 2015

肺移植のおけるドナーの遺伝子

Tanaka et al, 2012○

タバコ誘発肺障害

Chen et al, 2015○○

敗血症由来の肺障害

Zhai et al, 2015; Tao et al, 2016; Yu et

○

○

○

○
○

変化

al, 2019; Zhai et al, 2019

9

〇

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
肺

細胞

齧歯類

その他動物

投与形態
ヒト

培養液 生食水ガス

出血性ショック誘発肺障害

Kohama et al, 2015

○

○

肺移植

Noda et al, 2014; Liu et al, 2015; Saito○○

et al, 2019
海水注入で誘発した肺障害

Diao et al, 2016

大気汚染で誘発された肺障害

Gong et al, 2016

肺気腫

Suzuki et al, 2017○

下肢の虚血再灌流障害による肺Zou et al, 2018〇

敗血症で誘発した肺障害

Dong et al, 2018〇

Naphthalene 誘発急性肺障害

Terasaki et al, 2019〇

ブレオマイシン誘発肺線維症

Gao et al, 2019

〇

間質性肺炎

Terasaki et al, 2019〇

PM2.5 誘発肺障害

Feng et al, 2019〇

喘息および COPD

Wang et al, 2020〇〇

コロナウイルス感染症 2019

Guan et al, 2020〇〇

OVA で誘発した喘息

Xiao et al, 2013; Zhang et al, 2018;

○

○
〇

〇
○

〇

障害

気管

〇
〇
〇
〇
〇

○

〇

○

Huang et al, 2019; Zhao et al, 2020
気道狭窄患者の気道抵抗

Zhou et al, 2018

閉塞性気道疾患

Ozeki et al, 2019

〇
〇

10

〇
〇

その他

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
心臓

細胞
急性心筋梗塞

Zhang et al, 2011; Sun et al, 2009;

投与形態

齧歯類

その他動物

ヒト

培養液 生食

○

○

〇

○

水

ガス

その他

○

Hayashida et al, 2008; Yoshida et al,2012; Sakai et al, 2012; Jing et al,
2014;

Katsumata

et

al,

2017;

Asanuma et al, 2017; Feng et al, 2018
心移植

Nakao et al, 2010a; Noda et al, 2012;

○

○

○

Noda et al, 2013
左心室肥大

Yu et al, 2012; Matsuoka et al, 2018○

放射線誘発心筋障害

Qian et al, 2010a; Kura et al, 2019○

睡眠時無呼吸で誘発された心臓

Hayashi et al, 2011○○

心肺停止蘇生後の脳・心臓障害

Hayashida et al, 2012○○

心肺停止蘇生後の脳障害

Huang et al, 2013; Hayashida et al,

○

〇

○
○

の低酸素症

○

○

○

2014; Chen et al, 2019
Shinbo et al, 2013○○

Kato et al, 2014○○

糖尿病性心筋症

Wu et al, 2015○

心筋細胞の虚血による障害

Xie et al, 2014

虚血再灌流傷害とニトロチロシ
ン産生
低酸素による左心室リモデリン
グ

○

11

○
○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
心臓

細胞
心臓の虚血再灌流障害

Tan et al, 2013; Zhao et al, 2014;

齧歯類

その他動物

○

○

投与形態
ヒト

培養液 生食

水

ガス

その他

○

〇

○

○

Zhang et al, 2015; Pan et al,2015; Zalesak et al, 2017; Gao et
al, 2017; Li et al, 2019; Yao et al,
2019; Li et al, 2019a; Li et al,
2019b; Li et al, 2019c; Li et al,2020; Nie et al, 2021
ドキソルビシン誘発心不全

Wu et al, 2014○○

ドキソルビシン誘発心筋障害

Gao et al, 2017〇〇

LPS 誘発心不全

Tao et al, 2015○○

心停止後の心機能と神経学的転帰

Wang et al, 2016

○

心停止後

Tamura et al, 2016; Tamura et al,

○
○

○

2020

心停止後の心筋損傷

Wang et al, 2017

圧負荷で誘発した心肥大

Fan et al, 2018〇

心停止後の神経学的アウトカム

Chen et al, 2017〇

心血管代謝リスク

Korovljev et al, 2018

○

○
〇
〇
〇

12

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
心臓

細胞

齧歯類

その他動物

投与形態
ヒト

培養液 生食Chen et al, 2018〇〇

心筋障害とアクアポリン発現Song et al, 2018〇〇

低酸素誘発心機能不全

Zhao et al, 2019〇

心肥大と心房細動

Wang et al, 2020〇

狭心症

Si et al, 2021

住血吸虫に起因した慢性肝炎

Gharib et al, 2001○

肝炎

Kajiya et al, 2009a○

非アルコール性脂肪性肝疾患

Kawai et al, 2012; Zhai et al, 2017;○

心肺バイパスで誘発された心筋障

水

ガス

その他

害

肝臓

〇
〇
〇

〇
○
○

〇

○

〇

〇

Jackson et al, 2018; Korovljev et al,
2019; Liu et al, 2020; Li et al, 2021
閉塞性黄疸Liu et al, 2010; Liu et al, 2016○○

四塩化炭素誘発肝障害

Sun et al, 2011a○○

肝腫瘍治療における放射線障害

Kang et al, 2011

肝臓の遺伝子発現

Nakai et al, 2011

肝切除による肝障害

Xiang et al, 2012

肝切除による肝不全

Tan et al, 2014

○

肝の線維化

Koyama Y et al, 2013

○

○

○

○

○
○

13

○
○
○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
肝臓

腎臓

細胞

齧歯類

その他動物

投与形態
ヒト

培養液 生食B 型肝炎

Xia et al, 2013

エンドトキシン誘発肝障害

Xu and Zhang, 2013○○

肝硬変の血行動態

Lee et al, 2014○○

アセトアミノフェン誘発肝毒性

Zhang et al, 2015

○

○

肝再生

Yu et al, 2015○

脂肪肝の虚血再灌流障害

Li et al, 2018〇〇

熱傷における肝機能

Liu et al, 2014○○

低酸素/再酸素化障害

Yu et al, 2015

アルコール性脂肪肝

Lin et al, 2017○

敗血症誘発肝障害

Yan et al, 2019〇

クロルピリホス誘発肝毒性

Xun et al, 2020〇

アルコール性肝炎

Yano et al, 2021

腹膜透析

Terawaki et al, 2013

シスプラチン誘発腎症

Nakashima-Kamimura et al, 2009;

○

○

水

ガス

○

○

○

○

○
○
〇
〇

〇

〇
○

○

○

○

○

○

Kitamura et al, 2010; Matsushita
et al, 2011b
ゲンタマイシン誘発腎毒性

Matsushita et al, 2011a

腎移植

Cardinal et al, 2010; Kobayashi etal, 2019

14

その他

○

〇

〇

○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
腎臓

細胞
腎の虚血再灌流障害

Wang et al, 2011b; Shingu et al,

齧歯類

その他動物

○

投与形態
ヒト

培養液 生食
○

水

○

ガス

その他

○

〇

2010: Abe et al, 2012; Zeng et al,2014; Li et al, 2016a; Li et al,
2016b;

Nishida

et

al,

2018;

Kawamura et al, 2020; Xu et al,
2019
メラミン誘発尿石

Yoon et al, 2011b

○

糖尿病腎症

Katakura et al, 2012; Jiao et al,

○

○
〇

○

2020
慢性腎臓病

Zhu et al, 2011○

急性腎障害（AKI）

Chen et al, 2017○○

片側尿管結紮による腎障害

Xu et al, 2013○○

鉄ニトリロ三酢酸誘発腎毒性

Li et al, 2013○

Dahl 食塩感受性ラットにおける心Zhu et al, 2013○○

横紋筋融解症における腎障害

Gu et al, 2014○○

自然発症高血圧ラット（SHR）にお

Xin et al, 2014

○

○

○

○

-腎障害

ける腎障害
敗血症ショック時の腎障害

Liu et al, 2014

○

15

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
腎臓

膵臓

細胞

齧歯類

その他動物

投与形態
ヒト

培養液 生食水ガス

造影剤誘発腎障害

Homma et al, 2015

○

○

腎石症

Peng et al, 2015○○

重症火傷における急性腎障害

Guo et al, 2015; Wang et al, 2018○○

肝移植後の急性腎障害

Du et al, 2016○○

腎障害と線維化

Xing et al, 2017

シュウ酸カルシウム誘発腎障害

Lu et al, 2018〇

多発性嚢胞腎Yamasaki et al, 2019〇〇

敗血症誘発腎障害

Yao et al, 2019〇〇

シクロスポリン誘発腎毒性

Lu et al, 2020〇〇

外傷誘発膵炎Ren et al, 2012○○

タウロコール酸誘発膵炎

Shi et al, 2015

○

○

急性膵炎

Chen et al, 2010c; Zhang et al,

〇

○

〇

〇

その他

〇
〇

○

○

○

○

2012; Zhang et al, 2013; Ren et al,2014; Zhou et al, 2016; Han et al,
2016; Li et al, 2021
精巣膵臓移植後の虚血再灌流障害Lou et al, 2015○○

急性壊死性膵炎

Shi et al, 2016○○

精巣の虚血再灌流障害

Jiang et al, 2012a; Lee et al, 2012○

精巣の放射線障害

Jiang et al, 2012b○

生殖細胞の放射線障害

Chuai et al, 2012a

○

16

○

○
○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患

細胞

齧歯類

その他動物

投与形態
ヒト

培養液 生食Chuai et al, 2012b○○

ニコチン誘発性精巣障害

Li et al, 2013○○

精子の生存率Nakata et al, 2015

煙草煙誘発精巣障害

Chen et al, 2015○○

脊髄切断で誘発した精巣障害

Ge et al, 2017〇〇

精子形成と精子生存率

Ku et al, 2020〇〇

シスプラチン誘発卵巣障害

Meng et al, 2015○○

早発卵巣不全He et al, 2016○○

卵巣の虚血再灌流障害

Gokalp et al, 2016

○

○

子宮内膜症

He et al, 2016

○

胃または

ストレス誘発胃潰瘍

Liu et al, 2012○

腸アスピリン誘発胃障害

Xue et al, 2014; Zhang et al, 2014○

腸移植

Buchholz et al, 2008; Zheng et al,○

精巣

放射線誘発精子形成障害と造血機

水

ガス

その他

能障害

卵巣

子宮

○

○

○
○
○
○

○

○

2009; Buchholz et al, 2011
潰瘍性大腸炎Kajiya et al, 2009b; He et al, 2013;

○

○

〇

Shen et al, 2017

出血性ショックにおける腸管障害

Du et al, 2015

○

17

○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
胃または

細胞
腸の虚血再灌流障害

Chen et al, 2011; Shigeta et al,

齧歯類

その他動物

投与形態
ヒト

培養液 生食

水

○

○

〇

ガス

その他

2015; Wu et al, 2017; Eryilmaz et腸al, 2019; Yao et al, 2019; Jiang etal, 2020; Yamamoto et al, 2020;
Yang et al, 2020

食道

血管

腸閉塞

Okamoto et al, 2016

○

○

胃移植

Ikeda et al, 2017○○

放射線による消化器障害

Xiao et al, 2018〇〇

腸内環境の改善

Higashimura et al, 2018〇〇

マイコトキシン誘発腸管障害

Xu et al, 2019〇〇

消化器症状の改善

Tanaka et al, 2018

放射線誘発小腸障害

Qiu et al, 2020

敗血症誘発腸管障害

Yin et al, 2021

遊走とアポトーシス

Li et al, 2017

逆流性食道炎Franceschelli et al, 2018

動脈硬化

Ohsawa et al, 2008○

アテローム性動脈硬化

Song et al, 2012

○

〇
〇

〇

〇
〇

〇

〇

〇

〇

〇
〇

18

〇
○

○

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
血管

細胞
バルーンで誘発した血管の内膜傷

齧歯類

Qin et al, 2012; Chen et al, 2013

○

その他動物

投与形態
ヒト

培養液 生食

○

水
○

ガス

その他

○

害と内膜肥厚移植血管における内膜肥厚

Sun et al, 2012a

○

○

血管傷害

Zheng et al, 2012○○

糖化最終産物誘発性の血管内皮傷

Jiang et al, 2013○○害
塩化カルシウムで誘発した動脈瘤

Chen et al, 2013; Song et al, 2013;○○

Chen et al, 2014
血管内皮機能Sakai et al, 2014; Ishibashi et al,

○

○

2020
血管内皮への単球接着と血管透過

Xie et al, 2015; Yu et al, 2015○○

性動脈硬化におけるプラーク

Song et al, 2015a

血管平滑筋の肥大・増殖

Zhang et al, 2016

血管の老化

Iketani et al, 2018〇

血管のリモデリング

Kiyoi et al, 2020〇〇

出血性ショックにおける血管内皮

Sato et al, 2020

〇

〇

○
○

○

○

○

○
〇

グリコカリックス
血流増加

Kato et al, 2021

〇

19

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
筋肉

細胞

齧歯類

その他動物

投与形態
ヒト

炎症性及びミトコンドリア性筋炎

Ito et al, 2011

○

筋肉疲労

Aoki et al, 2012; DA Ponte et al,○

培養液 生食

水

ガス

その他

○
○

2017; Botek et al, 2019
腓腹筋萎縮Fujita et al, 2011○○

骨格筋の虚血再灌流障害

Huang et al, 2015○○

軟部組織障害Ostojic et al, 2014

運動負荷による酸化ストレス

Yamazaki et al, 2015; Nogueira et

○
〇

○

○

〇

〇

al, 2018
筋ジストロフィー

Hasegawa et al, 2016

運動負荷

Todorovic et al, 2020; Botek et al,

○

○
〇

〇

〇

2021; Ito et al, 2020

軟骨・骨骨格筋の障害Nogueira et al, 2020

NO 誘発性軟骨障害

Hanaoka et al, 2011

微小重力による骨欠損

Sun et al, 2012b

○

○

骨減少症

Guo et al, 2012○○

TNFα誘発骨芽細胞傷害

Cai et al 2013○○

骨・軟骨組織の生存率

Yamada et al, 2014○○

破骨細胞の分化Li et al, 2014○○

ステロイド誘発大腿骨壊死

Huang et al, 2016; Li et al, 2017

骨の放射線障害Chen et al, 2020

〇

〇

○

○
〇

20

○

〇

○
〇

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患

細胞

齧歯類

骨

骨形成

Carnovali et al, 2021

腱

腱の接着と炎症

Meng et al, 2018〇

関節

関節リウマチIshibashi et al, 2012; Ishibashi et

○

その他動物

投与形態
ヒト

培養液 生食

〇

水

ガス

その他

〇
〇
○

○

○

○

○

al, 2014; Meng et al, 2016
乾癬性関節炎Ishibashi et al, 2015

○

○

歯

変形性関節症Cheng et al, 2020; Lu et al, 2021〇

歯周病

Kasuyama et al, 2011; Azuma et al,

○

〇

〇
○

〇
〇

○

2015; Nayak et al, 2021
歯周病における大動脈の脂質沈着

Ekuni et al, 2012○○

歯周組織の老化

Tomofuji et al, 2014○○

線維芽細胞の酸化ストレス

Xiao et al, 2016

歯肉の酸化ストレスと歯槽骨の再Yoneda et al, 2017

○

○

〇

〇

吸収

皮膚

口腔内バイオフィルム形成

Kim et al, 2017〇（微生物）

歯肉の酸化ストレス

Shamim, 2018〇

紫外線を照射した線維芽細胞傷害

Kato et al, 2012a

○

〇

〇

〇
○

○

○

とケラチノサイトのしわ形成
紫外線誘発皮膚障害

Yoon et al, 2011a; Guo et al, 2012

急性紅斑性皮膚疾患

Ono et al, 2012

○

○
○

21

○

○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
皮膚

細胞
皮膚移植における虚血再灌流障害

Zhao et al, 2013

紫外線誘発皮膚障害

Ignacio et al, 2013a; Zhang et al,

齧歯類

その他動物

投与形態
ヒト

培養液 生食

○

〇

水

ガス

その他

○

〇

○

○

2018
褥瘡

Li et al, 2013

アトピー性皮膚炎

Ignacio et al, 2013b; Yoon et al,

○

○

〇

○

○

〇

○

○

〇

○

○

2014; Kajisa et al, 2017
放射線誘発皮膚炎と皮膚障害

Watanabe et al, 2014; Zhou et al,
2018

熱傷の進行

Guo et al, 2015○○

火傷による炎症Wang et al, 2015○○

皮膚の虚血再灌流障害

Liu et al, 2015; Fang et al, 2018;

○

○

○

○

〇

Dong et al, 2019
局所の放射線照射による皮膚炎

Mei et al, 2014

皮膚老化

Wu et al, 2017

乾癬Zhu et al, 2018〇〇

ケラチン栓のクレンジング効果

Tanaka et al, 2018〇〇

褥瘡モデルにおける皮膚の虚血再Fang et al, 2018

〇

〇

〇

灌流障害

22

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
皮膚

代謝

細胞

齧歯類

その他動物

投与形態
ヒト

尋常性天疱瘡

Yang et al, 2019

皮膚フラップ

Sahin et al, 2020〇

I 型糖尿病Li et al, 2011; Amitani et al, 2013

○

○

Ⅱ型糖尿病

Kajiyama et al, 2008; Wang et al,

○

○

○

○

○

○

培養液 生食

〇

水

ガス

〇
〇
○

○
○

○

〇

2012; Zhang et al, 2018; Zheng etal, 2021
メタボリックシンドローム

Nakao et al, 2010b; Hashimoto et○al, 2011; Song et al, 2013; LeBaronet al, 2020; Xiao et al, 2021;
Masuda et al, 2021
高コレステロール血症

Zong et al, 2012; Song et al, 2015b

糖尿病及び肥満

Kamimura et al, 2011○○

糖尿病性勃起不全

Fan et al, 2012○○

糖尿病性網膜症

Feng et al, 2012; Xiao et al, 2012○○

肝細胞の脂肪酸取り込みと脂質蓄

Iio et al, 2013

○

○

○

積
脂質代謝

Kamimura et al, 2016; Liu et al,

○

○

2021
糖尿病における骨減少

Guo et al, 2017

〇

23

〇

〇

その他

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
代謝

細胞
肥満

齧歯類

その他動物

Nakasone et al, 2017; Korovljev et

投与形態
ヒト

培養液 生食

〇

水

ガス

その他

〇

al, 2018

周産期異糖尿病性神経障害

Jiao et al, 2019〇

新生児低酸素脳症

Cai et al, 2008; Domoki et al, 2010;

○

〇
○

〇

○

〇

○

○

○

Cai et al, 2009; Yang et al, 2016;

常Varga et al, 2018; Htun et al, 2019;
Wu et al, 2019子癇（妊娠高血圧腎症）

Yang et al, 2011; Ushida et al, 2016○

母体低酸素による脳障害

Liu et al, 2011○

新生児の高酸素誘発網膜症

Huang et al, 2012○

新生児における麻酔薬吸入で誘発

Yonamine et al, 2013○

新生児の壊死性腸炎

Sheng et al, 2013○○

胎児の海馬障害

Mano et al, 2014○○

新生児の脳室内胚芽層出血

Lekic et al, 2011○

LPS 誘発新生児肺傷害

Hattori et al, 2015○

新生児の神経血管障害

Oláh et al, 2015

新生児における麻酔薬吸入で誘発

Takaenoki et al, 2014○○○

された認知障害○○○○された母性行動の欠如

24

○
○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患

細胞

齧歯類

その他動物

投与形態
ヒト

培養液 生食水ガス

新生児の気管支肺異形成症

Muramatsu et al, 2016○○

LPS 誘発新生児脳障害

Imai et al, 2016○○

新生児低酸素性虚血脳症

Wang et al, 2020; Ke et al, 2020

〇

〇

〇

新生児の虚血性脳障害

Bai et al, 2016; Wu et al, 2019

○

○

〇

水制限で誘発した胎盤ストレス

Shi et al, 2018〇〇

妊娠性歯肉炎Shi et al, 2018

〇

〇

炎症・ア

Ⅰ型アレルギー

Itoh et al, 2009

○

○

レルギー

敗血症

Xie et al, 2010a; Li et al, 2012a; Xie

周産期異

その他

常

○

○

〇

○

et al, 2012; Liu et al, 2014a; Liu etal, 2014b; Li et al, 2014; Li et al,2015a; Li et al, 2015b; Yu et al,
2017; Iketani et al, 2016; Hong et
al,

2017;

Ikeda

et

al,

2017;

Saramago et al, 2018; Jiang et al,2020; Matsuura et al, 2021
ザイモザン誘発炎症

Xie et al, 2010b; Hong et al, 2016

LPS/IFN-γ誘発 NO 産生

Itoh et al, 2011

○

○

○

カラゲニン足浮腫およびマクロフ

Xu et al, 2012

○

○

○

ァージの TNFα産生

25

○

○
○
○

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患

細胞

炎症・ア

LPS 誘発マクロファージ炎症

Chen et al, 2013

レルギー

アレルギー性鼻炎

Zhao et al, 2017; Yu et al, 2017; Xu

齧歯類

その他動物

投与形態
ヒト

○

培養液 生食

水

ガス

その他

○

〇

〇

〇

〇

〇

FF, et al, 2017; Jin et al, 2018; Fanget al, 2018癌

抗炎症メカニズム

Ren et al, 2016

酸化ストレスと炎症反応

Sim et al, 2020

腹膜炎

Sada et al, 2021

舌癌細胞増殖Saitoh et al, 2008; Saitoh et al,

〇

〇
〇

〇

〇

〇

○

○

○

○

2009
肺癌細胞で誘発した血管新生

Ye et al, 2008

放射線誘発胸腺リンパ腫

Zhao et al, 2011

癌細胞殺傷作用

Kagawa et al, 2012

抗腫瘍作用

Dole et al, 1975; Zhao et al, 2019;

○

○

○

○

○

〇

○

Chen et al, 2019c; Akagi et al,
2018; Akagi et al, 2020
抗癌剤の抗腫瘍作用増強

Runtuwene et al, 2015

大腸がん患者の肝機能Yang et al, 2017

膠芽腫

Liu et al, 2019

胆嚢がんの縮小効果

Chen et al, 2019a; Chen et al,

○

○

〇
〇

2019b

26

〇
〇

〇
〇

〇
〇

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
癌

細胞
肺がんに対する抗腫瘍効果と副作

齧歯類

その他動物

Chen et al, 2020

投与形態
ヒト

培養液 生食

〇

水

ガス

〇

用軽減
Yang et al, 2020

〇

〇

〇

〇

肺がん増殖抑制効果

Wang et al, 2018

〇

〇

〇

〇

肺がん患者の免疫機能

Chen et al, 2020; Chen et al, 2021

制がん効果

Kato et al, 2021

モノクロタリン誘発肺高血圧

Wang et al, 2011c; He et al, 2013;

子宮内膜がんに対する効果とその
メカニズム

高血圧

〇
〇

〇
〇

○

○

○

Kishimoto et al, 2015その他

低酸素誘発高血圧

Guan et al, 2018〇〇

血圧低下効果Sugai et al, 2020

〇

〇

潜水病

Ni et al, 2011○

多能性幹細胞の生存

Kawasaki et al, 2010

放射線誘発細胞傷害

Qian et al, 2010b; Qian et al, 2010c〇○

酸化 LDL 誘発細胞毒性

Song et al, 2011○○

高グルコース誘発酸化ストレス

Yu et al, 2011○○

AAPH 誘発酸化ストレス

Yanagihara et al, 2005○

寿命

Yan et al, 2010; Klichko et al, 2019

○

○

○

27

○

○

○

その他

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
その他

細胞
運動負荷による酸化ストレス

齧歯類

Koyama et al, 2008; Tsubone et al,
2013;

Dobashi

et

al,

その他動物
○

投与形態
ヒト

培養液 生食

○

水

ガス

〇

〇

2020;

Shibayama et al, 2020
運動負荷による代謝性アシドーシ

Ostojic et al, 2014○

LeBaron et al, 2019; Hori et al,

〇

〇

〇

〇

〇

〇

○

ス
運動負荷軽減効果

2020
運動能力改善Javorac et al, 2019; Hori et al,2020; Timon et al, 2021

血小板凝集

Takeuchi et al, 2012

放射線誘発アポトーシス

Yang et al, 2012○

ラジカル産生および血液流動性

Kato et al, 2012○

骨髄移植における GVHD（移植片Qian et al, 2013○

Qian and Shen, 2016; Qian et al,

〇

○

○

○

○

○

○
○
○

対宿主病）
慢性 GVHD

○〇○

2016; Qian et al, 2020
再生不良性貧血

Zhao et al, 2013○○

放射線誘発免疫機能障害

Zhao et al, 2014

○

○

急性腹膜炎

Zhang et al, 2014

○

○

28

その他

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
その他

細胞
出血性ショックDu et al, 2014; Matsuoka et al,

齧歯類

その他動物

投与形態
ヒト

培養液 生食

○

水

ガス

その他

〇

○

2017; Tamura et al, 2020
血液幹細胞移植

Yuan et al, 2015

○

○

情報伝達

Sobue et al, 2015

○

○

○

組織内濃度

Liu et al, 2014; Yamamoto et al,

○

○

○

○

2019
ヒトリンパ球細胞に対する 12C6＋

Yang et al, 2013○○

重イオン照射膀胱下尿道閉塞

Miyazaki et al, 2015

口蓋内創傷

Tamaki et al, 2016

細胞死と老化

Han et al, 2016; Han et al, 2017

○

細胞老化

Hara et al, 2016; Zhang et al, 2018;

○

○

○

○

○
○

〇

○

〇

Sakai et al, 2019
潜在出血

Qian et al, 2017〇〇

放射線誘発造血幹細胞障害

Zhang et al, 2017〇〇

培養細胞における活性酸素消去

Hamasaki et al, 2017

〇

29

〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
その他

細胞
免疫活性

Hu et al, 2017; Chen et al, 2021

酸化ストレスLee et al, 2017; Liu et al, 2018; Lu

齧歯類

その他動物

〇

投与形態
ヒト

培養液 生食

〇

〇

水

ガス

〇

〇

その他

〇

et al, 2019
術後腹腔内癒着

Liu et al, 2017

マイコトキシン含有飼料による成Zheng et al, 2018

〇

〇
〇

〇

長抑制
抗疲労効果

Ara et al, 2018; Watanabe et al,

〇

〇

〇

2018
遺伝子発現のメタ解析

Nishiwaki et al, 2018

酸素毒性の軽減Yu et al, 2017

遺伝子発現の修飾作用

Sobue et al, 2017

酸素グルコース欠乏とアポトーシ

Mo et al, 2018

〇

〇

創傷治癒

Li et al, 2018〇〇

抗酸化活性と腸内フローラ

Sha et al, 2018

解毒機構への影響

Yao et al, 2019

フリーラジカル誘発細胞死

Iuchi et al, 2019

内臓脂肪と皮膚のしみ

Asada et al, 2019

ミトコンドリア機能

Gvozdjakova et al, 2019

〇

〇

〇

〇
〇

〇

ス

〇

〇

〇

〇

〇

〇
〇
〇

30

〇
〇

対象器官

疾患又は疾患モデル

著者及び報告年

使用動物種

又は疾患
その他

細胞
LDL 誘発炎症

Yang et al, 2018

足首の捻挫

Javorac et al, 2020a; Javorac et al,

齧歯類

その他動物

投与形態
ヒト

〇

培養液 生食

水

ガス

その他

〇
〇

〇

〇

2020b
抗疲労効果

Botek et al, 2020〇〇

水素水の作製条件と唾液中の酸化

Tanaka et al, 2020

〇

〇

還元電位
スーパーオキシド生成抑制

Ishibashi et al, 2020

生理学的機能Xun et al, 2020

血中濃度

Sano et al, 2020a; Sano et al, 2020b

抗酸化、DNA 酸化障害、糖尿病マ

Asada et al, 2020

〇

〇
〇

〇
〇

〇
〇

〇

〇

ーカー
トリチウム暴露で誘発された放射Li et al, 2021

〇

〇

〇

〇

線毒性
腹側陰茎のフラップ

Gulburun et al, 2021

水素水マスクの抗酸化効果

Kwon et al, 2020

抗酸化および抗炎症作用

Hu et al, 2021〇

腎保護効果および神経保護効果

Kobayashi et al, 2020〇

後肢の虚血再灌流障害

Tong et al, 2021

〇

〇

〇
〇

2021 年 6 月 25 日までの掲載論文を MiZ 株式会社で調査し本資料を作成した。

31

〇
〇
〇
〇

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41epithelial-to-mesenchymal transition and pulmonary fibrosis. Med Sci Monit, 23: 2357-2364.
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Du Z, Jia H, Liu J, et al (2014a): Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. J Surg Res, 2014 Jul 3. pii: S00224804(14)00629-5. doi: 10. 1016/j. jss. 2014. 06. 051. [Epub ahead of print].
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