The 10th Annual Meeting of JSIT
2003.9.25-26.
Greenhall Sagamiono (Sagamihara)
President: Hiroshi Hojo (Showa Pharmaceutical University)
Special Lecture
The interaction between genetic
and environmental factors ;allergy as a model of common
disorders ?

Taro Shirakawa

Department of Health
Promotion and Human
Behaviour , Kyoto
University School of
Public HealthJun-ichi Sawada

Division of Biochemistry
and Immunochemistry,
National Institute of
Health Sciences

memorial Symposium

Progress and problem of
immunotoxicological research.
－From analytical stage to
Mechanism-based stage－Hiroshi Hojo

Department of HygienicChemistry, Showa
PharmaceuticalUniversity
Department of
Toxicology andEnvironmental Health,Development and Future
Perspective of
Immunotoxicological
KenoteResearch … From theLecture
Analytical Stage to theMechanism - based

Motoyasu Ohsawa

Stage

Faculty of
Pharmaceutical Science,
Teikyo University,
Sagamiko, Kanagawa,Japan

Animal models for food allergy
Reiko Teshima
and the evaluation of allergenicity

Division of Biochemistryand Immunology,
National Institute ofHealth Sciences

Toxicological Evaluation ofEnvironmental Chemicals utilizing Hidekazu Fujimaki.
Animal model.

Environmental HealthSciences Division,
National Institute forEnvironmental Studies

Molecular toxicological approach
for immunotoxicity evaluation indrug development … Introductionof toxicopanomics(Ikuo Horii
toxicogenomics、toxicoproteomics, metabonomics)
to immunotoxicological science …

Worldwide Safety
Sciences, Global
Research ＆Development, Pfizer
Inc.

Symposium <1>
Chemical Sensitivity
Fujio Kayama

Center for Community
Medicine, Division ofEnvironmental
Medicine, Jichi Medical
School, Tochigi, Japan

Environmental HealthCenter, The Kitasato

Kou Sakabe

Institute, Kitasato
University, Tokyo, Japan
Department of Health

Immunological effects byformaldehyde - Experimental
evaluation by using mice -Takahiko Yoshida

Science, Asahikawa
Medical College,Asahikawa, Japan
Department of Basic

Behavioural change in the pups
produced by perinatal low

Hiroyuki Aikawa

concentration formaldehyde

Clinical Science andPublic Health, Tokai
University School ofMedicine, Knagawa,Japan

The Role of " Neuro - Endoocrine- Immune " Axis in Chemical
Sensitivity

Environmental HealthCenter, The Kitasato
Institute, Kitasato
University, Tokyo, Japan

Kou Sakabe

Symposium <1>

Toxicity assessment and side
effect of biomedicine

Non - clinical experiments andclinical trials of new biologics inJapan

Complications of interferon
therapy and their managemant

Shiro Ueda

Department of Drug
Information andCommunication,Graduate School of
PharmaceuticalSciences, Chiba
university, Chiba, Japan

Michihito
TakahashiShowa University,School of
PharmaceuticalSciences

Organizer

Tamiko Suzuki Nishimura

The Organization for
Pharmaceutical Safety
and Research (OPSR)

Osamu Yokosuka

Department of Medicine
and Clinical Oncology
Graduate School of
Medicine, Chiba
University, Chiba, Japan
Department of Drug
Information andCommunication,
Graduate School of
Pharmaceutical
Sciences, Chiba
university, Chiba, Japan

Efficacy and adverse reactions ofanti -TNF - α monoclonal antibody
Shiro Ueda
in the treatment of rheumatoid
arthritis

Workshop <1>
International harmony of
immunotoxicological evaluation
method concerning medicine
Guidance for Immunotoxicity
Testing (Draft) and ICH.

Organizer

KazuichiNakamura

Jun-ichi Sawada

Developmental
Research Laboratories,
Shionogi & Co., Ltd.,
Osaka, Japan
Division of Biochemsitry
and Immunochemistry,
National Institute ofHealth Sciences, Tokyo,
Japan
Safety &Pharmacokinetics
ICH Immunotoxicology Survey

Shigeru Hisada

Research Department,
Teikoku Hormone Mfg.,
Co. Ltd.

Workshop <2>
Research &Problems in the evaluation
methods for antigenicity

Organizer

Eiji Maki

Development Division,Janssen Pharmaceutical
K. K.
Research &The controversial point ofantigenicity test in development

Eiji Makiof medicines
Usefulness of Mouse Popliteal
Lymph Node Assay as anAllergenicity Test.

Development Division,
Janssen Pharmaceutical
K. K.

T Aida, T Kimura

Medicinal Safety
Research Laboratories,
Sankyo Co., Ltd

Role of GSH in Arsenicals Induced Immnotoxicity

Teruaki Sakurai, Kitao
Fujiwara.

Laboratory ofEnvironmental
Chemistry, School ofLife Science, Tokyo
University of Pharmacy
and Life Science

Effect of inorganic arsenic
exposure from the before matingon the immune system of mouseoffspring.

T. Itoh (1) T. Yoshida Y,Nakagi (1), K Nakai (2),C. Watanabe (3), H.
Yamauchi (4) H.
Satoh(2)Asahikawa MedicalCollege, (2) Tohoku
University, (3)University of Tokyo, (4)St. Marianna University

General Oral Presentation(1)Department ofHygiene & Preventive

Metal - induced
histomorphological injury and thealterations in the amounts andYasuaki Arakawa (1),proportion of unsaturated
Kanako Nishimura (1),disaccharides ofglycosaminoglycan derived from

Toshio Imanari (2)proteoglycan.

Medicine, Faculty of
Health Science, The
University of Shizuoka,(2) Department ofAnalytical Chemistry,
Faculty ofPharmaceutical Science,
The University of Chiba.

Beneficial effects of a milk drink
fermented by lactic acid bacteria
on NK cell activity in healthy
human subjectｓ with smoking
habit(+)-Catechin protects against

M , Nanno . (1), Y,
Matshuoka(2), T,
Takeshita(2). , K ,Morimoto (2)Fumihide Takano (1),(1)Yakult Central
Institute forMicrobiologicalResearch, (2)Osaka
University Graduate
School of Medicine
Faculty of Medicine(1) Departmennt of

myelotoxicity in mice treated with Tomoaki Tanaka (2), Jiro Chemistry and5-fluorouracil.
Aoi (2), Nobuo Yahagi
Pharmacognosy, Faculty(2), Shinji Fushiya (2)of PharmaceuticalScience, Kanazawa

University, (2)Experimental Station
for Medicinal PlantStudies, Graduate
School of
Pharmaceutical
Effects of a Statin, simvastatin,on human myeloma cells

T Otsuki , H Sakaguchi,

Dept . Hyg ., Kawasaki

T Hatayama , A Takata , Med . Sch . Kurashiki,
F HyodohJapan(1) Hatano Reseach
Yukiko Kanazawa (1),Murine Food Allergy Model with
Oral Sensitization and Oral
Challenge (1)Tomoko Shindo (1),
Yoshiaki Saito (1), KenjiUsumi (1), Kohichi
Kojima (1), Reiko
Teshima (2)Institute, Food andDrug Safety Center,Kanagawa,Japan, (2)Division of Biochemistry
and Immunochemistry,
National Institute of
Health Sciences, Tokyo,Japan

Murine Food Allergy Model with
Oral Sensitization and Oral
Challenge (2) - Observation of
Small Intestine as a SpecificParameter -Tomoko Shindo (1),Yukiko Kanazawa (1),
Yoshiaki Saito (1), Kenji
Usumi (1), Kohichi
Kojima (1), Reiko
Teshima (2)Effect of the phosphodiesterase
Kouya Yamaki, Xiaojuan
Ⅳ inhibitor rolipram on Th 1/Th 2
Li, Shin Yoshino
immune responses
Makoto Seo, Koji Ikeda,
Takeo Yamagiwa,
Tadayoshi Ikemoto,
solvent on type I allergic reaction
Masahiko Sato andEffects of chlorinated organic

Hisamitsu Nagase
Kenzaburo Yamadi (1),Miho Aoki (1), Ryoji(1) Hatano ResearchInstitute, Food andDrug Safety Center ,Kanagawa, Japan, (2)Division of Biochemistry
and Immunochemistry,
National Institute of
Health Sciences, TokyoJapan
Department ofPharmacology, Kobe
Pharmaceutical
University
Laboratory ofHygienics, Gifu
Pharmaceutical
University, Gifu, Japan(1) Department ofHygienic Chemistry,

Identification of tissues producing Zuinen (1), Junko Ito
IL-6 in rats treated i. p. with(1.2), Mitsune

Showa PharmaceuticalUniversity.,

carbon tetrachloride(2)Laboratory ofBiochemisry, Sagami
Women's University

Yamaguchi (1),Toshiyuki Chikuma (1),Hiroshi Hojo (1)(1)GeriatricPharmacology andTherapeutics, Graguate
Immunotoxicity of di-2ethylhexylphthalate (DEHP) inrodents

School of
Pharmaceutical
S. Ohara (1.2), K . Ueno
Sciences, Chiba(1) and T . Takezawa (2)University,(2)Laboratory of Animal
Cell Biology, National
Institute ofAgrobiological Sciences17 β-Estradiol enhances mouse
contact sensitivity

Humitoshi Sakazaki,

Department of

Kazunori Fujii, Yasunori
Ishikawa, SayakaKodama, Hitoshi Ueno

environmental health,
Faculty of
Pharmaceuticaland KatsuhikoNakamuroSciences, Setsunan
University

Sensitizer in conformity with
globally harmonized system ofclassification and labelling of

Department ofK. Sato, Y. Kusaka

chemicals (provisional list)

Enviromental Health,
School of Medicine,
Fukui Medical University

General Poster Presentation
Ryosuke Nakamura,Division of Biochemistry

Effect of dialkyl phthalates on the Haruyo Okunuki, Yoshiro and Immunochemistry,
activation of mast cells
Saito, Reiko Teshima,
National Institute ofJun-ichi Sawada

Evaluation of the effectiveness ofrat peripheral lymphocytes
phenotyping

Health Sciences.

Satoko Kakiuchi, Hideshi
Safety research
Kaneko, Kimiko
department,Jonouchi, Sachiko
Pharmaceuticals
Ohara, Natsuki Kitaima,
development research
Yoshimi Sato, Azusa
laboratories, Teijin
Tamura, Daishiro Miura,
LimitedYoshinori Kasahara
University of Shizuoka,

The influence of mental stress on
serum albumin in mouse

Nobuhiro Goi et al

Aichi Medical Universityand Osaka Pref.
Institute of Public
HealthKoichi Hayashi, Tadashi
Kosaka, Yukiko Takeuchi,
Historical date of anti - SRBC
antibody titers in wistar rats

Sayaka Ishimine,
Tsutomu Matsumoto,Hideaki Fujie, Yasufumi

Institute ofenvironmental
toxicology

Shutoh and TakanoriHarada(1)Department ofThe apoptosis induced bytributyltin (TBT) chloride in

Masashi Tsunoda (1),Ken Nakano (2),murine macrophage cells in vitro

Nobuhiro Konno (3)Pubulic Health, Schoolof Medicine, Fukushima
Medical University,(2)Fukushima Instituteof Public Health,(3)Koriyama Women's
University & College(1) Division ofDifferential effects of resveratrol
on apoptosis of
spleniclymphocytes

Jianhong ZHAO(1)(2)，

EnvironmentalImmunology andYukitomo Arao(1)(2)，
Kazuhiro Ikeda(1)(2)，
Atsumi Kikuchi(1)(2)，

Toxicology, Department
of Health Science , Jichi
Medical School,Fujio Kayama(1)(2)(2)CREST, Japan
Science and TechnologyCorporation

Degradation of glyceraldehyde-3- Yukihiro Tsuｃhiya,
phosphate dehydrogenase
Mitsune Yamaguchi,
induced by 4-hydroxy-2-nonenal Kayoko

Department of HygienicChemistry, Showa

and acrylonitrile, and distribution

Hishinuma,Atsushi

Pharmaceuticalof its degradation enzyme inmononuclear cells

Shimada, Toshiyuki
Chikuma, Hiroshi Hojo

University

Respiratory sensitization studiesof 2 agricultural chemicals byHideo Ueda, Tadashi
Kosaka, Koichi Hayashi,using a challenge phase-added
mouse IgE test

Koichi Ebino, Shoji
Teramoto

Analysis of responsible factors forInstitute ofEnvironmental
Toxicology

Masao Sato (1), Minoru(1)Tokushima Bunri

Higashimoto (1), Miwa
Yanaga (1), Masafumi

University, Faculty of
Pharmaceuticalchanges in tissue concentration ofTakiguchi (1), Masuo
zinc
Kondoh (2), Shinya
Suzuki (1)Sciences, (2)Syowa
PharmaceuticalUniversity(1)Dept. Toxicol.

F. Otsuka (1), S.

Environ. Health, Fac.

Alteration of type 1 and type 2
cytokine levels in the peripheral

Sasamoto (1), K.
Takahashi (1), T.

Pharmaceutical Sci. ,Teikyo University,

blood during the juvenile period

Yoshida (2) and M.

(2)Department ofOhsawa (1)Hygiene, Asahikawa
Medical College(1)Environmental
Health Sciences
Division, National

K. Inouye (1,2), X. Pan
Effects of low doses of dioxin on(1,3), N. Imai (4), C.

immune response

Tohyama (1,3), and K.
Nohara (1,3)

Institute forEnvironmetal Studies;(2)Domestic Research
Fellow, JSPS; (3)CREST,JST; (4)Safety researchGroup 3, Shin NipponBiomedical
Laboratories, Ltd.

T. Ito (1,2), S. Tsukumo(1,2), M. Yamamoto(1)National Institute for

Growth inhibition in Jurkat T cells (2,3), H. Motohashi (3),Environmental Studies,

having a constitutively active aryl N. Suzuki (3), Y. Fujii hydrocarbon receptor
Kuriyama (2,3), J.

(2)CREST, JST, (3)TARA
Center, University of

Mimura (3), C. Tohyama Tsukuba.
(1,2), K. Nohara (1,2)
Y. Sato(1) , H.
Akiyama(1),Inhibitory effect of feeding βcarotene on typeⅠallergy in miceT.Watanabe, (1), M.H.
Nagaoka(1), H.
Suganuma(2), T.
Inakuma(2), T.

(1)National Institute of
Health Sciences,(2)Research Institute,
Kagome Co. LtdMaitani(1)Development of a modified local
lymph node assay with non radio isotopic endpoint andapplication to risk assessment ofchemicals

Yamashita K. , Idehara

Daicel ChemicalK.

Industries, LTD.