Life Science and Technology
Innovation in Scotland

Mr Yasutsune Kanatani
Scottish Development International

Scotland
From our people to our quality of life, there
are many reasons companies choose to start,
grow and invest in Scotland:• 5.3 million people - 8.3% of UK (2012) and a stable
population• Well connected (exchange of knowledge, transport ofpeople and shipment of products) and supportive
environment• Foreign investment in Scotland stands at a 15 year high
10.9% of all UK FDI projects• Most medical research per head of population in Europe• Strong history of medical innovation and scientificdiscovery

Relationship Model
Support for Scottish companies operating in national and international
markets• International support• Strategic worldwide footprint• Scotland wide support for growing companies• 1:1 support through account management• Focused support for the Highlands and Islands• Key contact for Digital Health and Natural Resources

Trade
Inward Investment

Infrastructure
Financial Support

Strategic Support

Supporting Company Location
SDI actively manage relationships with more than 400 inward investors in
Scotland to nurture & build on the 150,000 jobs they provide
Location &Property Advice

Access to Scottish
Research Capabilities

Business
Development Support
PR Services
Investment Incentives• Regional Selective
Assistance• Equity Funding

Staffing &Recruitment
Marketing &Market Research

Investment Advice
Grants
• R&D Grant• Additional Innovation
Grants

Dedicated AfterCare
Tax Incentives• Tax Credits• Patent box

A History of Innovation
Scotland has a strong track record of Innovation2010
Big DNA

1853

1929

1974 -1980

1980s

2007

Alexander Woodinvented the first
hypodermic
syringe

Sir Alexander
Fleming
discovered
penicillin

John Mallard andJames
Hutchinson
developed the
MRI scanner

Sir James Black
received a Nobel
Prize fordiscovering beta
blockers

Touch Bionics
word’s first multiarticulated handdevelops 1st
bacteriophage
DNA vaccine
deliverytechnology

1923

1950s

1980s

1990s

2010s

2012

John Macleod
won a Nobel
Prize fordiscovering
insulinIan Donald
pioneeredultrasoundscanning in
gynaecology

Sir David Jackdeveloped
Zantac andVentolin

Optos developed
the first scanning
laser
ophthalmoscope

AircraftMedicalinvented theworld's firsthandheldvideo-enabledlaryngoscope

Edixomed Ltd
has developed
a nitric oxide
dressing whichheals chronic
leg ulcers
rapidly

Life Sciences Landscape
NHS Scotlanda single healthcare
systemover 170 core
medical devicecompanies

cluster ofworld classresearchers andcliniciansLife Sciences in Scotland

Cradle to Gravesingle medical record

a world leading
centre forstem cell research &regenerative medicine

Growing Digital and Connected
Health capabilities and assets
More than 30,000
employees in over 600
organisations

Over

160

pharmaservicescompanies

Innovative start ups to major global players

COMPANY BASE

Areas of Strength

Scotland hosts one of the most sizeable Life Sciences clusters in Europe

MedicalTechnologies

PharmaServices

Regenerative
Medicine

Connected
Healthcare

Precision
Medicine

AnimalHealthPharmaceutical
ServicesDrug discovery excellence in Scotland•

Scotland has a history of drug discovery excellenceand Scottish scientists:• Discovered world’s first vaccine against viral
Hepatitis B• Awarded Nobel prize for discovering beta blockers• Discovered Atracurium, the world’s best-sellingmuscle relaxant• Discovered Salbutamol, the world’s best-selling
asthma treatment• Discovered Zantac for peptic ulcers•

Innovative discovery assays supporting early lead
identification and validation•

Host to Joint European Compound Library andEuropean Screening Centre, part of £100m EU project

Drug Discovery

Scotland has world classdiscovery consortia involving
the world’s biggest
pharmaceutical companies

Strengths of pharmaceutical services in Scotland• More than 160 companies employing over 9,000
people with a turnover of £1.2bn1% of Pharmaceutical Services Sector byCompany Capability• Global CROs and specialist service providers
ensure a comprehensive supply chain across allstages of drug discovery and development• 60% of Europe’s biopharmaceutical safety
testing is carried out in Scotland2• Preferred clinical trial site for Pfizer, PPD,
Quintiles and Roche• Global leaders in pharmaceutical manufacture
AMRI, BASF, Capsugel, GSK and SAFC
recognise the advantages of operating in Scotland

Drug Discovery

13

Pre Clinical CRO

11

7

11

Clinical CRO
Pharmaceutical
Manufacture

14

13Specialist ProductSpecialist Service

22• Refined testing and manufacturing expertise in
fast-growing ADC market
1 Internal analysis 2014
2 Biopharmaceutical drug development capabilities: Benchmarking Scotland’s position versus key markets, Evolution LS 2010.

18

Clinical Trials Support
Statistical, Regulatory,
Logistics & Quality

A comprehensive supply chain in Scotland
Scotland’s Pharmaceutical Services sector incorporates every stage of thecomplex and diverse drug discovery, development and manufacturing process
Scotland fulfils all stages of drug development
Drug Discovery

Basic Research
Lead Discovery

Lead Optimisation
Preclinical Validation

Preclinical CRO

Regulatory toxicology
Investigative toxicology
Biopharmaceutical safety
Safety Pharmacology

Carcinogenicity
DMPK

Clinical CRO

Phase I
Phase II
Phase III
Post Market Surveillance

Pharmaceutical
Manufacture

Contract Manufacture
Commercial Manufacture

Biostats
Regulatory
Data Management
Study Monitoring
Drug Delivery
Drug Formulation

Service & Product Innovation
Tissue provision, discovery tools,
specialist imaging analysis services,
regulatory consultancies, data
management, supply chain logistics, data
analytics etc.

Scotland delivers across all stages of drug development

Innovative and expert pre-clinical testing in Scotland•

Global leaders in preclinical contract research are
based in Scotland such as Bioreliance, BioOutsource
and Charles River Laboratories•

Niche expertise in companies such as Biopta, Tissue
Solutions and Clyde Biosciences provide innovative
solutions to pre-clinical efficacy and safety testing.

•Diverse Capabilities including investigative toxicology,
safety evaluation, laboratory sciences and expert in-vivo
scanning and imaging capabilities•

Bespoke testing and formulation expertise in fastgrowing ADC market

Preclinical CROs

60% of Europe’s preclinicaltesting of
biopharmaceuticals iscarried out in Scotland

Globally competitive clinical research in Scotland
Clinical CROs

Scotland is one of the top
5 sites world wide forrecruitment and start up
times.

•

Preferred clinical trial site for Quintiles, PPD and Pfizer•

Managed clinical trial delivery through NHS Research Scotland•

Globally Competitive trial recruitment and start-up times(commercial approval 20 days)•

A unified health provider (NHS) with outstanding collaboration
across academia government and industry and a unique patient
identifier number (CHI) used from cradle to grave creating aunique environment for data driven clinical research•

Access to Clinical investigators and patients across all major
therapeutic areas including diabetes, oncology, dementia, MS andstroke•A clinical CRO company base that can support Phase I to IVclinical trials and post-market surveillance.

Globally competitive clinical research in Scotland cont.
Streamlined process for feasibility and to obtain R&D permission for
multicentre research in Scotland:
Aberdeen

Inverness
Highland CRF
Lipidomics Research Facility
Highland Surgical Research
Facility

DundeeGlasgow
Biomedical Research Centre
Glasgow Clinical Research Facility(multiple hubs)
BHF Cardiovascular Research Centre
CRUK Beatson Institute
Beatson Oncology Centre
MRC Social and Public HealthServices Unit
Sackler Institute

CRUK Laboratories
Dundee ClinicalResearch Facility
Health Informatics
CentreMedicines Monitoring
Unit

NRS Permissions Coordinating
CentreInstitute of Medical Sciences
Institute of Applied Health
Sciences
Aberdeen Clinical Research
Facility
Health Services Research Unit
Health Economics Unit

Edinburgh
Edinburgh Bioquarter
Wellcome Clinical Research Facility
Queen’s Medical Research Institute
Institute of Genetics and Molecular
Medicine(MRC/CRUK/UoE)
Edinburgh Neuroscience
Farr InstituteInnovative manufacture and drug delivery in Scotland
Pharmaceutical
Manufacture
Global leaders inpharmaceutical manufacture
recognise the advantages ofoperating in Scotland•

30 dedicated pharmaceutical manufacture and speciality
formulation companies located in Scotland•

Improved cost efficiencies through widespread lean
processes.

•

Strong compliance badging and supply security•

Global top two universities for pharmacological research•Innovative manufacture solutions such as XstalBio andSolid Form Solutions providing bioformulation andcomplex delivery expertise.

•

Industry leaders AMRI, BASF, Capsugel, GSK and SAFC
recognise the advantages of siting global operations in
Scotland.

Diverse and expert products and services in Scotland
Specialist Service +Product Innovation
Excellent transport links withreliable courier services
delivering to most of Europe
within 24 hours.

•

Deliver to most European destinations within 24
hours; Scotland’s dominance in preclinical testing inEurope is reflected in Scotland’s specialised logistics
network•

Over 50 specialist service and product companies
including data analytics, imaging analysis, drug
discovery platforms, clinical trial packaging, quality
management systems, regulatory consulting, tissue
procurement, genetic testing•

Reliable supply chain logistics•

Comprehensive bio and health informatics
infrastructure and existing company base

Regenerative
MedicineStem Cells and Regenerative Medicine: Vision
Our vision is for Scotland to be Europe’s leading location for the developmentof stem cell applications, and to establish the optimum environment fortranslating research into therapeutic benefits for patients.

Scotland's reputation as one of the leading
locations for the development of new tools andtechnologies, as well as the clinical assessmentof new cell-based therapies, is due to:• its connectivity• its comprehensive translational, clinical,
analytical and regulatory support mechanisms.

Scottish Government Investment
Scotland is one of the world’s leading locations for stem cell the Scottish
Government has, since 2004, invested over £100 million across various
interventions to help translate this expertise into applied medicine and practice
Innovation & Infrastructure

Funding

PeoplePromotion

Manufacturing: Roslin
Cells

Scottish Centre forRegenerative Medicine

Scottish Enterprise &MRC Cell Technology
Translational Fund

Skills Development
Scotland – Life
Sciences Skills
Investment Plan

International Promotion

Manufacturing: Blood
Cells

Manufacturing: Cell
Lines for Pre-Clinical
Use

Scottish Enterprise &UKSCF Cell Therapy
Translational Fund

Attracting Talent for
Scottish Centre forRegenerative Medicine

International
Collaborations &Partnerships

Scotland’s Stem Cell Cluster“Scotland's reputation as a leading location for the development of new tools
and technologies, as well as the clinical assessment of new cell-based
therapies, is due to its connectivity and to its comprehensive translational,
clinical, analytical and regulatory support mechanisms.”
Over the last ten years Scotland has:
• Capitalised on its world-leading researchexpertise in stem cells• Invested in the infrastructure andcommercial support necessary to create
a viable industry cluster and• Created a strong supply chain as well as
strong inclusive and collaborative
community.

http://www.lifesciencesscotland.com/solutions/scotland's-strengths/stem-cells.aspx

Home to one ofEurope’s largest
and most highly
regarded stem
cell researchhub
Access tooutstanding
clinical expertise
Notabletemperature
controlled
logistics
services

Proven trackrecord insupporting andimplementing
cell therapy
clinical trials
Long term
government
commitment tothe sector
Vibrant life
sciences &stem cellcommercial
landscapeStem Cells Commercial Landscape
R&D
Therapeutics&
Manufacturing
Drugdevelopment,
Tools &
Services
Enabling
technologies& Contract
Research
Regulatory
Advice &Guidance

Logistics

Pre-Clinical

Phase 1

Phase 2Phase 3+

Launch
Product

Successful Delivery of Cell Therapies
Scotland is one of Europe’s leading locations for the development of stem cellapplications.
Cell Therapies in Clinical Practice

Cell Therapies in Clinical Development

Pancreatic islet programme representing 50%
of UK islet transplants

Phase I CTX stem cellline for critical limb
ischemia

Phase I/II CD133 cells
for chronic liver
failurePhase IIb T-cell
immunotherapy formelanoma

EBV Cytotoxic T lymphocyte (CTL) bank totreat patients with post-transplant lymphoproliferative disease including refractory EBVdriven non-Hodgkin’s lymphoma

Phase I/II corneal
epithelial stem celltransplant for corneal
blindness

Phase I ReN001
neural stem celltherapy for patientsleft disabled byischemic stroke

Phase II MultiStem forischemic stroke

Scotland has significant expertise in regulatory approval & clinical trials

Regenerative Medicine at Edinburgh BioQuarter
The MRC Centre for Regenerative Medicine is a world leading research centre basedat the University of Edinburgh, studying stem cells, disease and tissue repair toadvance human health.
•World Leading
Research

•
•
•
•
•

•

iPS Cell Bank

•
•
•
•

The Niche••

Cell Therapy
Manufacturing•••

Scottish Centre for Regenerative Medicine - MRC Centre for Regenerative Medicine:
Pluripotency & iPS
Lineage & Cell Specification
Neural Differentiation & Tissue Repair (Brain & Spinal Cord)
Haematopoietic Stem Cell Biology & Regeneration (Blood)
Liver Stem Cell Biology & Tissue Repair
Roslin Cells Leads European iPS Cell Bank
€35 million project
European consortium of 26 partners including Neusentis/ Pfizer, AstraZeneca, H. Lundbeck, Janssen and
UCB Pharma
Leading facility for storage and distribution of iPS cells£25M Regenerative Medicine Platform funding to boost the development of regenerative medicine
therapies£5M for Edinburgh Stem Cell Niche Hub£10M for Edinburgh Computational and Chemical Biology of the Stem Cell Niche
Roslin Cells & SNBTS
6 Cell Therapies Manufactured at EBQ including cell therapies for
Pfizer/Neusentis & Reneuron

Medical Technologies

Scotland’s Multinational Medtech Companies
A number of companies have grown in Scotland to become global players
based on Scottish innovation/IP

Toshiba Medical
Visualisation Systems
Europe• Voxar : Founded early
1990s• Powerful 3D CT, MR
imaging software• Nov 2008 – acquired by
Toshiba• Based in Edinburgh

LifeScan Scotland• Created in 2001 when
Johnson & Johnson
acquired Inverness
Medical Ltd.
• Employ over 1,000
people• Main area ofinterest:diabetes.
• Main product is the
OneTouch® Brand ofblood glucose
monitoring systems

Optos Plc
• Founded in 1992
• Scanning laser
ophthalmoscope captures a digital ultra
wide-field image of theretina in a single take
• Over 33 million eye
performed
examinations so far,
$196m turnover in2012

Vascutek Terumo• Founded 1982
• Develop andmanufacture vascularimplants• Growth fuelled bystrong R&D capability
most recently in
endovascular area

Innovative Start-ups
Scotland is the UK’s leading location for Life Sciences Start-ups
Number of Start-up Companies in the UK 2007-11

50

Approx half of all life science
start ups from 2005-2009
were Medtech focused(approx 22 in total).

40
30
20

Medtech Start Ups– Ambicare– Mode Diagnostics

10– Reactiv Lab0– Ohmedics– Vueklar– i2eye Diagnostics– Taragenyx

UK Life Sciences Start Up Report 2010 and 2012, Mobius Life Sciences

Academic Research in Medical Technologies
Scotland’s research base offers easy access to a wealth of world-class,expertise and facilities as well as depth of relevant experience in convergent
technologies critical to development of modern medical technologies• Scotland’s 15 universities are all involved in groundbreaking med-tech research• Centres of excellence:– Strathclyde Institute for Medical Devices– Institute for Medical Science and Technology in
Dundee• University pools are gateways to academic
excellence• Strathclyde Medtech: Strathclyde Institute of Medical
Devices is running a supporting scheme for industry
and academia collaboration

Commercial innovations
Scotland has an impressive track record of medical innovations:
In the past decade, Scotland’s medtech companies have launchedglobal health innovations including:• A portable unit to treat non-melanoma skin cancer using
photodynamic therapy – Ambicare• The first scanning laser ophthalmoscope to provide enhanced
clinical information to detect diseases of the retina - Optos• The world’s first commercially available multi-articulated
prosthetic hand – Touch Bionics• A hand-held light-based device for checking breast health –PWB Health• The world's first handheld video-enabled laryngoscope tofacilitate intubations – Aircraft Medical

Connected HealthConnected Health
Outstanding level of collaboration between industry , universities, NHS and
Government – open innovation environment
Industry collaboration is a key part of the vision in creating a world leading R&D environment todevelop informatics based healthcare solutions of the future.
Strong Academic And Commercial Base• Scotland is building on a strong academic and commercial base in informatics to develop work classinfrastructure to support the continuing move towards a connected and personalized healthcare
environment.

Stable Population• In comparison to rest of UK and US populations, Scotland has an incredibly stable population. It has

cradle to grave patient records underpinned by the Community Health Index (CHI) number; the only
unique patient identifier for Scotland assigned to everyone who is registered with a GP practice.

Centralised Healthcare Provider• A centralised healthcare system- including a national Picture Archiving System (PACs)- and a highincidence of morbidity of common complex diseases.

These elements make Scotland well differentiated to develop new solutions for healthcare
based around informatics, big data and patient stratification.

Connected HealthContinuing to develop and build upon current strengths and expertise:
Scottish Health Informatics
Programme (SHIP)• $6.4m collaboration of four Scottish universities and the NHS todeliver improved infrastructure and governance for research using
linked health records in Scotland.

e-Health Informatics ResearchCentre (e-HIRC)• One of 4 UK e-health informatics research centres with Scotland’s

Health Informatics Research
Advisory Group (HIRAG)• Developing a national strategy for health and bioinformatics

The Farr InstituteScottish Informatics & Computer
Science Alliance (SICSA)
Significant Academic Expertiseand Growing Company Basecentre leading the UK-wide network.
research in Scotland.
• Investment builds on the e-HIRCS to strengthen the UK’s capacity

to analyse patient records and health data in safe environments.
• This university research collaboration that allows companies toengage with 10 of Scotland’s software universities via one accesspoint.
• e.g. Aridhia, OracleBio, Pharmatics Ltd, Toshiba, Craneware

Digital Health in Scotland“Scotland has a highly collaborative Telehealthcare community drawing
together leading academics, policy makers, multinational companies and a
globally admired National Healthcare Service”. 1• Strong government push, favourable environment (policy & financial- ₤98M pa)• Scotland will integrate health and care – led by NHS24 (different toEngland and Wales)

Ageing population• A total investment of up to £23 million is being made in the UK-wide

Rise in long term conditions
DALLAS programme – Delivering Assisted Living Lifestyles at Scale. and co-morbidity
This comprises an £18m investment by the Technology Strategy
Board and the National Institute for Health Research, with a further£5m contribution from the Scottish Government, Highlands andIslands Enterprise and Scottish Enterprise.

• CHI Number: Anonymised electronic patient health information• Around 100 Scottish companies active in this space• Recently launched Digital Health Institute1 George Crooks OBE, Medical Director NHS 24

Health Service Constraints
Personalisation of Medicine
Low carbon economy

Digital Health Cluster
A highly networked, innovative community of pioneers from business,academia and healthcare• Rapid growth in activity with a world-class pool of skills and talent• A highly networked, innovative community of pioneers from business, academia andhealthcare with a fully representative supply chain• At Scale Deployment: One of the world largest deployments of digital healthcare is underway (initiated in 2012).
• New national Innovation Centres in digital health, stratified medicine and sensors

DesignR&D

Manufacturing

Legal

Scottish Digital
Health Cluster

Clinical Expertise

Regulator and testing

Healthcare Services

Market intelligence &health economics

The Digital Health InstituteMission: To develop products and services that will result in a step change inhealth and care delivery• Enable collaboration between industry, National
Health Service (NHS), care, academia• Agile design processes to assist productdevelopment• Trials and evaluation facilities• Open to all companies to participate

Working together to deliver solutions in Scotland

Life Science Advisory Board – Industry, Academia, NHS and Government

Edinburgh BioQuarter
Scottish Centre forRegenerative Medicine
230 Researchers

No 9, Bioincubator

Royal Infirmary
900 beds
Medical School
250 Researchers

Anne Rowling Regenerative
Neurology Clinic

Clinical Research
Imaging Centre

Clinical Research Facility
MHRA Accredited Phase I
Unit

Queen’s Medical
Research Centre
650 ResearchersSouth Glasgow Hospital Campus

An Ethos of Innovation through Collaboration

SMSIC• Stratified Medicine Scotland IC

DHI• Digital Health IC

IBioIC• Industrial Biotechnology IC

CMAC• Cont. Manufacturing & Crystallisn

HIP• Health Innovation Partnership

NRS• NHS Research Scotland

Joined up healthcare environment
A patient-centric, technology-agnostic future requires use of multiple biomarker
types, access to retrospective/prospective database and clinical judgment

Farr
Institute
Clinicalresearch
infrastructureSinapse(imaging)

Nationwide
PACS

Nationalpatient erecords

Centralised
healthcare

Big data -IC

ClinicianCommand Centre
BioQuarter
Stratified
medicine-IC

DigitalHealth-IC有難う 御座いますarigatou gozaimasu
Thank you!