台灣國立交通大學理學院應用化學系
雷射生物奈米科學研究室
研究成果活動報告書
民國 97 年 4 月 〜 107 年 3 月
Laser Bio/Nano Science Laboratory
Department of Applied Chemistry, National Chiao Tung University(NCTU)
Activity Report(2008 April - 2018 March)

Increasing Visibility of NCTU
in Science and in Japan

PrefaceIn the autumn of 2007 I was invited by Prof. Yuan-Pern Lee to visit
NCTU (National Chiao Tung University) and exchanged our opinions onsome topics of mutual interest with him and prominent scientists ofDepartment of Applied Chemistry (DAC). Also we discussed on how todevelop our science, university, and academic exchange internationally,
and consequently I shifted from Osaka to Hsinchu on April 2018. OurLaser Bio/Nano Science Laboratory started smoothly and now ten years
have passed away. I chose laser trapping as a central subject among
my topics in the past, considering various situations and conditions
about NCTU, fund, staff, my age, and of course my interest, I believedthat originality and uniqueness of laser trapping dynamics and chemistrywere enough high, international competitiveness was expected, andunconventional and seminal study would evolve from our laboratory.
Laser Bio/Nano Science Laboratory has been developing supported byAiming-Top-University (ATU) project of NCTU and Ministry of Education(MOE). Now my contract of 5 years-2 terms with our presidents isending, and we are happy to summarize our activity in this small booklet.
Due to our systematic scientific contribution, we are now regarded as
one of the world-level centers studying laser trapping dynamics andchemistry. Additionally we have devoted our efforts for academic
exchange between Taiwan and foreign countries particularly Japan, sothat not only professors and researchers but also many people including
even high school students have visited to NCTU, DAC, and our Laser
Bio/Nano Science. Our past ten years activity is well summarized with aconcluding word “Increasing Visibility of NCTU in Science and in Japan”.
Here I would like to express my sincere thanks to my colleagues, friends,assistants, students and funding, and most importantly to President Drs.
Peter Chung-Yu Wu, Yan-Hua Wu Lee, and Mau-Chung Frank Chang,
Deans of College of Science Drs. Jenh-Yih Juang, Henry Horng-Shing
Lu, Yaw-Kuen Li, and Yung-Fu Chen, and DAC Chairs Drs.
Weng-Sheng Chung, Niann-Shiah Wang, and Chi-Shen Lee for theirkind understanding and strong supports. Finally, my most sincere
1

thanks are dedicated to Prof. Yuan-Pern Lee for his kind and fairmanagement based on his wonderful scientific project.
March 29, 2018

Hiroshi MASUHARA

2

Research Activity
Published Papers

Invited lectures

Education Activity
PhD Students

1 PhD student promoted as Professor ofJapanese University

Master Students

Dual Degree Students (3 with Japanese
University and 1 with Belgian University)
Japanese Graduate Students staying in Our
Laboratory for 1~3 months
Our Students Studying Abroad for 1 – 2years

3

Academic Exchange Activity
Staffs Promoted to Japanese andBrunei Universities

Japanese Staffs married with
Taiwanese ladies

Japanese Postdoctoral Fellows
supported by JSPS (Japan Society for
Promotion of Science)

Japanese Professors we invited toDepartment Seminar

Japanese Professors we invited toLaboratory Seminar
Participants to Hsinchu Summer
Course and Workshop on Single
Molecule/Nanoparticle Spectroscopyand Imaging
Japanese Super Science High School
students we received

4

5

Present Members
Hiroshi MASUHARA
増原 宏
Dr. Hiroshi Masuhara graduated fromTohoku University (1966) in Sendai andobtained Ph.D. degree from Osaka
University (1971). He is a physical chemist
working in multidisciplinary areas indepartmentsofchemistry(Tohoku
Painted byUniversity), synthetic chemistry (OsakaProf. Toshitsune MIYAKEUniversity),polymerscienceandMathematician,engineering (Kyoto Institute of Technology),
Prof. Emeritus ofapplied physics (Osaka University), frontier
Hokkaido University
bioscience (Osaka University), life science(Hamano Foundation), and materials science (Nara Institute of Scienceand Technology). In 2008 he joined Department of Applied Chemistry ofNational Chiao Tung University as Chair Professor. He has published
about 600 papers, 160 reviews and 19 books. In Laser Bio/Nano
Science Laboratory he has extended seminal researches on (1) laser
trapping dynamics of nanoparticles, (2) laser trapping crystallization ofmolecules and proteins, and (3) application of femtosecond laser andchemical surface modification for fabricating individual cell-baseddevices.

Academy Member(1) Foreign Fellow of National Academy of Sciences, India (2010 present)(2) Foreign Member, Flemish Academy of The Art and Sciences,Belgium (1998 - present)6

Honor, Award, and Prize(1) 2017 The Order of the Sacred Treasure, Gold Rays with NeckRibbon (The Emperor of Japan)(2) 2010 Mukai Prize(3) 2010 Mizushima-Raman Lectureship (JSPS-India DST)
(4) 2010 Asian Photochemistry Association Award(5) 2008 Outstanding Scholar Award (Foundation for theAdvancement of Outstanding Scholarship, Taiwan)(6) 2008 The Purple Ribbon Medal (The Emperor of Japan)(7) 2006-2013 Doctor Honoris Causa de Ecole Normale Superier deCachan, FranceSociety Fellow(1) JPA (Japanese Photochemistry Association) Emeritus Member(2017~present)(2) CSJ (Chemical Society of Japan) Fellow (2010 - present)
Journal Editor(1) Advisory board (2008 - present)
The Chemical Record(2) Advisory board (2005 - present)Bulletin of the Chemical Society of Japan(3) Editorial board (2000 - present)
ChemPhysChem(4) Editorial board (1997 - present)
Journal of Photochemistry and Photobiology C: Photochemistry
Review(5) Asian Editor (1997 - 2011), Editorial Board (2012 - present)
Journal of Photochemistry and Photobiology A: Chemistry
President, Advisor, and Councilor(1) Advisor (2016 - present)
Center for Excellence in Exciton Science, Australian ResearchCouncil, Australia(2) Advisor (2016 - present)
Japan Society for Promotion of Science Project, Grant-in-Aid for
Scientific Research on Innovative Area on “Nano-MaterialManipulation and Structural Order Control with Photon Forces”
7

(3) Advisor (2014 - present)
Japan Society for Promotion of Science Project, Grant-in-Aid for
Scientific Research on Innovative Area on “Application ofCooperative Excitation into Innovative Molecular Systems with High
Order Photofunctions”(4) Advisor (2013 - 2018)
Japan Society for Promotion of Science Project, Grant-in-Aid for
Scientific Research on Innovative Area on “Dynamical ordering of
biomolecular systems for creation of integrated functions”(5) Review Committee member (2013 - 2016)
Research Center of Applied Sciences, Academia Sinica(6) Executive Advisor (2013 - 2016)
Institute for Molecular Science, Japan(7) President (2002 - 2004), Advisor (2005 - present)
The Asian and Oceanian Photochemistry Association(8) International Advisor (2002 - 2016)
Interuniversity Attraction Pole Project on Supramolecular Chemistry
and Catalysis, Belgian Federal Science Policy Office, Belgium(9) Councilor and Advisor (2001 - present)
The Laser Society of Japan(10) President (2000-2001), Advisor (2003-present)
Japanese Photochemistry Association
Masuhara Lectureship Award
Asian and Oceanian Photochemistry Conference started this award in2012.
HIROSHI MASUHARA FESTSCHRIFT (Special Issue)
2009 Journal of Physical Chemistry C, America Chemical Society

89Teruki SUGIYAMA
杉山 輝樹
Dr. Teruki Sugiyama received B. Eng.
degree from Shinshu University in 1994 andPh.D. from Nankai University, P. R. China in
2002. He was Designated Instructor,Specially-Appointed
Instructor,andSpecially-Appointed Fellow in Department ofApplied Physics at Osaka University from 2002-2007. In Osaka
University, he studied the fabrication of organic and pharmaceutical
nanoparticles utilizing laser ablation in solution, and succeeded intailoring the smallest organic dye nanoparticles by the top-down method
using ultrashort laser. In 2007, he became Researcher at Hamano Life
Science Research Foundation, where he started his current research
topic on the development of laser trapping method to crystal chemistry.
From 2008 to 2011, he worked at Nara Institute of Science andTechnology as Associate Professor and at Instrument Technology
Research Center, National Applied Research Laboratories as Associate
Researcher and Research Fellow from 2011 to 2015, when he extended
his research on laser trapping chemistry. He moved to National Chiao
Tung University as Associate Professor of Applied Physics in 2007. His
main areas of research interest are laser nano chemistry ofmolecular/cluster systems for two research topics: “Laser trappingchemistry” and “Laser bio/nano application”.

10Physical Chemistry Chemical Physics (Back cover)20, 6034–6039 (2018)“Rapid localized crystallization of lysozyme by laser trapping”

11Tetsuhiro KUDO
工藤 哲弘
Dr. Tetsuhiro Kudo obtained the Ph.D. degreefrom Department of Physics and Electronics,
Osaka Prefecture University, Japan (2014). He
has worked in Department of Applied
Chemistry, National Chiao Tung University inTaiwan as JSPS (Japan Society for thePromotion of Science) Overseas Research Fellow and Post-doc(2014-2016). He is currently working as Assistant Research Fellow from2017. He is a theoretical and experimental physicist starting academiccareer in Taiwan, and recently discovering and investigating the novel
laser trapping phenomena of nanoparticles based on light propagationand scattering at an interface. He has received 2016 Inoue ResearchAward for Young Scientists in Japan, EXCON2012 Young Scientist
Award in Netherlands, and Poster award at 2017 Spring Symposium ofThe Asian and Oceanian Photochemistry Association in Taiwan.
Our Nono Letters is cited as a key scientific article in Advances inEngineering. (https://advanceseng.com/ )Nano Lett., 2016, 16(5), 3058-3062

12

Laboratory Staffs
Hiroshi Masuhara
Chair Professor
2008.04 - present増原宏Teruki Sugiyama
Associate Professor
2015.08 - present
杉⼭輝樹
Atsushi Miura
Assistant Professor
2009.09 - 2014.04
三浦篤⼠
Associate Researcher
2008.04 - 2009.08
Takayuki Uwada
Assistant Researcher
2008.04 - 2012.03
宇和⽥貴之
Anwar Usman
Post Doctoral fellow
2009.06 - 2013.06
吳安華Kenichi Yuyama
Assistant Researcher
2014.01 - 2016.09
柚⼭建⼀
Post Doctoral Fellow
2011.04 - 2013.12
Kazunori Okano
Assistant Researcher
2013.06 - 2015.12
岡野和宣
Post Doctoral Fellow
2012.08 - 2013.05
Masayasu Muramatsu Post Doctoral Fellow
2014.04 - 2015.10
村松正康
JSPS Overseas Research Fellow
2012.04 - 2013.03
Tetsuhiro Kudo
Assistant Researcher
2017.01 - present
⼯藤哲弘
Post Doctoral Fellow
2016.04 - 2016.12
JSPS Overseas Research Fellow
2014.04 - 2016.03
Shun-Fa Wang
Post Doctoral Fellow
2017.02 - 2017.07
王順発
Yugo Hayashi
JSPS Overseas Research Fellow
林有吾
2015.06 - 2015.08
2016.02 - 2016.03
Morihiko Hamada
JSPS Overseas Research Fellow
濱⽥守彦
2015.04 - 2016.03
Wen-Yu Lee
Assistant
2008.04 - present
李⽂郁
Yi-Chun Lee
Assistant for Research 2009.08 - 2010.0
李依純

13

JSPS Overseas Research Fellows
1.
2.
3.
4.

Masayasu Muramatsu
Tetsuhiro Kudo
Morihiko Hamada
Yugo Hayashi村松正康
⼯藤哲弘
濱⽥守彦
林有吾

2012.04 - 2013.03
2014.04 - 2016.03
2015.04 - 2016.03
2015.06 - 2015.08
2016.02 - 2016.03

Students
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
19.
20.
21.
22.
23.
24.
25.
26.
27.

Ping-Yu Hsu
Jing-Ru Tu
Tsung-Han Liu
Chun-Wei Huang
Wei-Yi Chiang
Shun-Fa Wang
Ching-Shu Tseng
Zu-Wei Hsu
Yen-Hwa Huang
Ling-Ting Huang
Chi-Shuen Wu
Chun-Shen Wu
Po-Yu Lin
Ding-Wen Jian
Chun-Han Wang
Pei-Yun Hseh
Jen-Lian Shu
Po-Ren ChenKai-Di Chang
Lin-Li Liu
Tse-Fu Hsen
Yuan-Lin Yi
Ping-Shun Peng
Mong-Wei Chou
Ray-Kai Chen
Yung-Lun Lin
Shang-Wei Lou

許平諭
杜靜如
劉宗翰
⿈重維江威逸王順發曾綮續許孜瑋
⿈彥樺⿈鈴婷吳奇勳吳峻陞林柏宇
簡⿍⽂王崇翰謝沛芸徐禎蓮
陳伯任張凱迪劉林禮
沈則甫
易宛霖彭炳順卓孟瑋陳睿凱
林詠倫
劉上瑋

(PhD)
(PhD)
(MS, PhD)(MS)(MS, PhD)(MS, PhD)
(MS)
(MS)
(MS)
(MS)
(MS, PhD)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(BS, MS)
(MS)
(MS)
14

2009.08 - 2015.01
2009.08 - 2016.01
2009.08 - 2017.08
2010.02 - 2011.11
2010.08 - 2017.11
2010.08 - 2017.01
2010.08 - 2013.08
2010.08 - 2013.08
2010.08 - 2013.08
2010.08 - 2013.08
2011.08 - present
2012.08 - 2015.02
2012.08 - 2014.07
2013.07 - 2015.07
2013.07 - 2015.07
2013.07 - 2015.07
2013.07 - 2015.09
2013.08 - 2015.07
2013.08 - 2015.07
2013.08 - 2016.01
2013.09 - 2015.07
2014.04 - 2015.12
2014.08 - 2016.10
2014.08 - 2015.07
2014.08 - present
2015.02 - 2017.08
2015.08 - 2016.09

28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.

Chi-Lung Wu吳奇隆
Shang-Jan yang
楊尚展
An-Chieh Cheng
鄭安婕
Tsung-Wei Shieh
施宗緯
Chieh-Ju Chang
張傑茹
Ting-Shiang Chiou 邱⿍翔Ching-Shiang Tseng 曾靖翔
Yang-Hsin Shieh
施仰欣
Jhao-Rong Lin
林昭容
Pei-Hua Lo羅珮華
Jia-Syun Lu呂佳勳
Hao-Tse Su
蘇浩澤
Zhi-Hao Huang
⿈之灝Yu-Ming Wang
王裕明
Chia-Ying Tsai
蔡佳穎
Abdullah Kamit卡蜜濤
Yen-Ling Chiou邱彥苓Yen-En Liu
劉⾔恩
Yi-Ju Wu吳奕儒
Hsuan-Yin Wang
王暄尹
Wen-Chi Wang
王玟淇

(MS)
(MS)
(MS, PhD)(MS, PhD)(MS)(BS, MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(MS)
(BS)
(BS)
(BS)
(BS)
(BS)

2015.08 - 2017.08
2015.08 - 2017.10
2015.08 - present
2015.08 - present
2015.09 - 2017.08
2015.03 - present
2016.07 - present
2016.02 - present
2016.06 - present
2016.07 - present
2017.07 - present
2017.07 - present
2017.07 - present
2017.07 - present
2017.09 - present
2018.02 - present
2013.08 - 2015.06
2015.07 - 2017.08
2016.07 - present
2017.07 - present
2017.07 - present

Dual Degree Program Students
1.
2.
3.
4.

Shinpei Nishimura (Saitama University - NCTU)
⻄村晋平
2012.08 - 2015.09
Kazuki Okano(Saitama University - NCTU)
岡野和希
2017.10 - 2018.03
Chiang Wei.-Yi.
(NCTU - Katholieke Universiteit Leuven)
江威逸2014.09 - 2017.11
Chi-Shuen Wu(NCTU - Saitama University)吳奇勳
2016.10 - 2017.09

15Financial Support by NCTU, NSC(National Science Council) and MOST
(Ministry of Science and Technology)
1.

Hiroshi Masuhara, 2008, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

2.

Hiroshi Masuhara, 2009, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

3.

Hiroshi Masuhara, 2010, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

4.

Hiroshi Masuhara, 2011, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

5.

Hiroshi Masuhara, 2011, President of NCTU
Title: 雷射⽣物奈⽶科學研究室

6.

Hiroshi Masuhara, 2012, President of NCTU
Title: 雷射⽣物奈⽶科學研究室

7.

Hiroshi Masuhara, 2012, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

8.

Hiroshi Masuhara, 2013, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

9.

Hiroshi Masuhara, 2014, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室

10. Hiroshi Masuhara, 2015, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室
11. Hiroshi Masuhara, 2016, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室
12. Hiroshi Masuhara, 2017, ATU Project of NCTU
Title: 雷射⽣物奈⽶科學研究室
13. Hiroshi Masuhara, 2018, President of NCTU
Title: 雷射⽣物奈⽶科學研究室
14. Hiroshi Masuhara, 2008.04 ~ 2009.03, NSC
Title: 雷射補陷結晶法之研究(1/3)
1615. Hiroshi Masuhara, 2009.04 ~ 2010.03, NSC
Title: 雷射補陷結晶法之研究(2/3)
16. Takayuki Uwada, 2009.08 ~ 2011.07, NSC
Title: 開發廣場雷利散射顯微影像技術用於探討蛋白質結晶的基
本過程
17. Hiroshi Masuhara, 2010.04 ~ 2011.03, NSC
Title: 雷射補陷結晶法之研究(3/3)
18. Hiroshi Masuhara, 2011.04 ~ 2012.03, NSC
Title: 純有機化合物液體中的雷射捕捉及結構組成(1/3)
19. Hiroshi Masuhara, 2012.04 ~ 2013.03, NSC
Title: 純有機化合物液體中的雷射捕捉及結構組成(2/3)
20. Atsushi Miura, 2012.08 ~ 2014.07, NSC
Title: 螢光蛋⽩雷射捕陷結晶化動⼒學：藉由⾮線性顯微成像研
究光壓誘發相分離及晶核形成
21. Hiroshi Masuhara, 2013.04 ~ 2014.03, NSC
Title: 純有機化合物液體中的雷射捕捉及結構組成(3/3)
22. Hiroshi Masuhara, 2014.05 ~ 2015.11, NSC
Title: 藉由三維觀測分析闡明奈⽶糰簇和奈米粒子的雷射捕捉,散射及緊合動⼒學
23. Kazuhiro Okano, 2014.01 ~ 2015.12, NSC
Title: 藉由在培養基⽚上的局部設計固定誘導分化因⼦達成細胞
分化在時空上的控制
24. Kenichi Yuyama, 2014.08 ~ 2016.07, NSC
Title: 雷射捕陷誘發分⼦與膠體晶體動態成⻑機制之反射影像光譜解析
25. Teruki Sugiyama, 2015.08 ~ 2016.07, MOST
Title: 雷射捕陷誘發叢集聚合區域之蛋⽩質結晶調控26. Hiroshi Masuhara, 2016.04 ~ 2017.03, MOST
Title: 雷射捕陷與雷射燒蝕誘發類澱粉蛋⽩之纖維化
27. Teruki Sugiyama, 2017.08 ~ 2018.07, MOST
Title: 藉由雷射捕陷技術控制結晶之對映現象(1/2)
28. Hiroshi Masuhara, 2017.08 ~ 2018.07, MOST
17

Title: 雷射捕陷與雷射燒蝕誘發類澱粉蛋⽩之纖維化
29. Tetsuhiro Kudo, 2017.10 ~ 2019.07, MOST
Title: 光傳遞及光散射促成之光捕陷誘發聚集18

Collaborative Publication withTaiwanese Professors

Langmuir, 2017, 33, 755-763

1920Laser Phys. Lett., 2014, 11, 076001

21

22

23

24