Poster List
One-minute poster presentation
17:15-18:20 Sep. 4 (Thu), main hall, Kumamoto City Medical Association Hall
Poster session
18:30-21:00 Sep. 4 (Thu), Poster Session Venue, Kumamoto City Medical Association Hall
12:20-14:20 Sep. 5 (Fri), Poster Session Venue, Kumamoto City Medical Association Hall
1
Analysis of long range chromatin interactions of the ESR1 locus in breast cancer under estrogendeprivation
Mohamed Osama Abdalla, Noriko Saitoh, Saori Tomita and Mitsuyoshi Nakao
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

2
Analysis of Tsukushi role during chick somitogenesis
Uzzal Kumar Acharjee1,2, Ryu Gejima1, Athary Felemban1, M. Ashrafuzzaman Riyadh1, Kunimasa
Ohta1 1Department of Developmental Neurobiology, Graduate School of Life Sciences, Kumamoto University; 2HIGO
program, Kumamoto University, Japan

3
Identification of bipotential hemogenic endothelial cells from embryonic stem cell culture
Tanzir Ahmed, Saeka Hirota, Kiyomi Tamura and Minetaro Ogawa
Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto,Japan

4Histone demethylase LSD1 regulates metabolism in skeletal muscle cells
Kotaro Anan, Shinjiro Hino, Akihisa Sakamoto, Katsuya Nagaoka, Ryuta Takase, and Mitsuyoshi
Nakao
Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto,Japan

5The endoplasmic reticulum-oriented drug development for familial amyloid polyneuropathy
Keisuke Chosa1, Ruiko Yamakawa1, Takashi Sato1, Takeshi Yokoyama2, Mineyuki Mizuguchi2, MaryAnn Suico1, Tsuyoshi Shuto1, Hirofumi Kai1
1

Department of Molecular Medicine, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, 5-1
Oe-honmachi, Kumamoto 862-0973, Japan; 2Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical
University, Toyama 903-0194, Japan.

6
Akhirin is involved in the neural stem cell regulation in the mouse spinal cord
Athary Felemban1,2,3, Rie Kawano1, Xiaohong Song1,2, Hideaki Tanaka1,2, Kunimasa Ohta1
1

Dep. Dev. Neurobiol., Grad. Sch. Life Sci., Kumamoto Univ.; 2GCOE, Kumamoto Univ.; 3Ministry of H. Edu., Saudi Arabia

7
New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee
blood
Yasumitsu Fujie1, Noemi Fusaki2,3,7, Tomohiko Katayama1, Makoto Hamasaki1, Yumi Soejima1,
Minami Soga1, Hiroshi Ban2, Mamoru Hasegawa2, Satoshi Yamashita4, Shigemi Kimura5, Hirofumi
Akari6 and Takumi Era1
1

Department of Cell Modulation, IMEG, Kumamoto Univ., Kumamoto, Japan; 2DNAVEC Corporation, Ibaragi, Japan;
Precursory Research for Embryonic Science and Technology, JST, Saitama, Japan; 4Department of Neurology, Graduate
School of Medical Sciences, Kumamoto Univ., Kumamoto, Japan; 5Department of Child Development, Graduate School of
Medical Science, Kumamoto, Japan; 6Section of Comparative Microbiology and Immunology, Center for Human Evolution
Modeling Research, Primate Research Institute, Kyoto Univ., Aichi, Japan; 7Department of Ophthalmology, Keio Univ.
School of Medicine, Tokyo, Japan.
3

8
VITAMIN C DEFICIENCY EXACERBATES RESPIRATORY FUNCTION AND
EMPHYSEMA IN EPITHELIAL NA+ CHANNEL-OVEREXPRESSING MICE
Haruka Fujikawa1, Yuki Sakaguchi1, Tsuyoshi Shuto1, Hirofumi Nohara1,2, Shunsuke Kamei1,2,
Yoshitaka Kondo3, Mary Ann Suico1, Akihito Ishigami3,4, Hirofumi Kai1,2
1Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University; 2Program for
Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto
University; 3Department of Aging Regulation, Tokyo Metropolitan Institute of Gerontology, Tokyo; 4Department ofBiochemistry, Faculty of Pharmaceutical Sciences, Toho University, Chiba

9
Induction of non-coding RNAs from a chromatin domain including the ESR1 locus in breast
cancer cells under estrogen deprivation
Saori Fujiwara1,2, Noriko Saitoh1, Saori Tomita1, Mohamed Osama Abdalla1, Hirotaka Iwase2 andMitsuyoshi Nakao1
1

Department of Medical Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto,Japan; 2Department of Breast and Endocrine Surgery, Graduate School of Medical Sciences, Kumamoto University,
Kumamoto, Japan

10
Podocyte-specific p53 deletion promotes progression of Alport syndrome by enhancement of
podocyte proliferation and migration
Ryosuke Fukuda, Yukari Kai, Kohei Omachi, Keishi Motomura, Tomoaki Koga, Kosuke Koyama,
Mary Ann Suico, Tsuyoshi Shuto, and Hirofumi Kai
Department of Molecular Mesicine, Graduate School of Pharmaceutical Science, Kumamoto University, Kumamoto, Japan

11
Analysis of reprogramming and iPS cells derived from Fibrodysplasia ossificans progressiva
Makoto Hamasaki1, Noemi Fusaki2, Yasuharu Nakashima3, Hirokazu Furuya4, Nobuhiko Haga5 andTakumi Era1
1

Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University; 2JST PRESTO
and Ophthalmology, Keio University; 3Department of Orthopaedic Surgery, Kyushu University School of Medicine;
4
Department of Aging Science, Cardiology and Neurology, Kochi University School of Medicine; 5Rehabilitation Medicine,
Graduate School of Medicine.

12
Analysis of the role of angiogenic factors in endothelial cells derived from iPS cells of moyamoya
disease patients
Shuji Hamauchi1, Akihiko Katayama2, Ippei Date2, Takumi Era2, Hideo Shichinohe1, Haruto Uchino1,
Naoki Nakayama1, Ken Kazumata1, Kiyohiro Houkin1
1

Department of neurosurgery, Hokkaido University, Hokkaido, Japan; 2Department of Cell Modulation, Institute of Molecular
Embryology and Genetics, Kumamoto University

13
Glucagon-GFP knock-in mice, a model to analyze development, differentiation and proliferationof islet α-cells and intestinal L-cells
Yoshitaka Hayashi
Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

14
SUV420H2 expression suppresses breast cancer cell invasion through expression of the SH2
domain-containing focal adhesion protein tensin-3
Yoshimi Shinchi, Ayaka Matsumoto, Yuhki Yokoyama, Nariki Matsuura, and Miki Hieda
School of Medicine and Health Science, Osaka University, Osaka, Japan15
The inhibitors for ribosomal RNA synthesis activate the hippo pathway effectors YAP/TAZ
Hiroki Hikasa and Akira Suzuki
Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

16
Actin regulates cell reprogramming
Takashi Ikeda, Takafusa Hikichi, Koji Kitazawa, Akira Watanabe, Akitsu Hotta and Shinji Masui
Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

17
Human Fibroblast Reprogramming by Lactic Acid Bacteria
Naofumi Ito, Rie Kawano and Kunimasa Ohta
Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan

18
Generation of human iPS cell lines labeling nephron progenitors
Yusuke Kaku, Atsuhiro Taguchi and Ryuichi Nishinakamura
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

19
Aberrant splicing of zinc transporter ZIP2 causes mucus hypersecretory phenotype in CF
airway epithelial cells
Shunsuke Kamei1,2, Tsuyoshi Shuto1,2, Keiko Shuto3, Haruka Fujikawa1, Hirofumi Nohara1,2, Chizuru
Matsumoto1, Yuki Sakaguchi1, Mary Ann Suico1,2, Ray A. Caldwell4, Dieter C. Gruenert5,6, Hirofumi
Kai1,2
1

Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto
862-0973, Japan; 2Program for Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Glocal Oriented)
Program”, Kumamoto University, Kumamoto 862-0973, Japan; 3Laboratory of Pharmacology, Sojo University Pharmacy
School, Kumamoto 860-0082, Japan; 4Cystic Fibrosi/Pulmonary Research & Treatment Center, University of North Carolina,
Chapel Hill, NC 27599-7248, USA; 5Departments of Otolaryngology - Head and Neck Surgery and Laboratory Medicine,
University of California, San Francisco, San Francisco, CA 94115, USA; 6Department of Pediatrics, University of Vermont
College of Medicine, Burlington, VT 05405, USA

20
Glomerular Proteome Analysis for Establishment of New Therapeutic Strategy in Chronic
Kidney Disease
M. Kamura, K. Koyama, K. Omachi, R. Fukuda, Y. Kai, M A. Suico, T. Shuto, and H. Kai
Department of Molecular Medicine, Kumamoto University, Kumamoto, Japan

21
Cadherin-7 joins dorsal-ventral patterning of the chick embryonic spinal cord through sonichedgehog signaling
Rie Kawano, Kunimasa Ohta, Naofumi Ito
Department of Developmental Neurobiology, Faculty of Life Science, Kumamoto University

22
The identification of master transcription factors in human corneal epithelial cells
Koji Kitazawa1,2, Takafusa Hikichi2, Takashi Ikeda2, Shinji Masui2, Takahiro Nakamura1, Morio Ueno1,
Satoshi Kawasaki1 and Shigeru Kinoshita1

1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Center for iPS Cell Research andApplication, Kyoto University, Kyoto, Japan

23
Bacterial c-di-GMP modulates HSCs and their niche through STING
Hiroshi Kobayashi1,2, Keiyo Takubo1,2, Toshio Suda1
1

Department of Cell Differentiation, the Sakaguchi Laboratory of Developmental Biology, Keio University School of
Medicine, Tokyo, Japan; 2Department of Stem Cell Biology, National Center for Global Health and Medicine, Tokyo, Japan

24
Systematic profiling of spatiotemporal tissue and cellular stiffness in the developing brain
Misato Iwashita and Yoichi Kosodo
Department of Anatomy, Kawasaki Medical School, Kurashiki, Japan25
A possible application of IncuCyte on the analysis of life span in C. eleganse
Masataka Moriuchi, Tsuyoshi Shuto, Yoshio Nakano, Mary Ann Suico, Hirofumi Kai
Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University

26
GLP-1
RECEPTORAGONISTEXTENDIN-4
EXACERBATES
MUCUS
HYPERSECRETORY PHENOTYPE IN EPITHELIAL NA+ CHANNEL-OVEREXPRESSINGCELLS AND MICE
Hirofumi Nohara1,2, Tsuyoshi Shuto1, Shunsuke Kamei1,2, Haruka Fujikawa1, Mary Ann Suico1, Ray A.
Caldwell3, Dieter C. Gruenert4,5, Hirofumi Kai1,2
1Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University; 2Program for
Leading Graduate Schools “HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto
University; 4Cystic Fibrosis/Pulmonary Research & Treatment Center, University of North Carolina, Chapel Hill, NC
27599-7248, USA; 5Departments of Otolaryngology - Head and Neck Surgery and Laboratory Medicine, University ofCalifornia, San Francisco, San Francisco, CA 94115, USA; 6Department of Pediatrics, University of Vermont College ofMedicine, Burlington, VT 05405, USA

27
Treatment approach for hypophosphatasia via genetically modified patient’s iPS cells and
iPS-MSCs
Yasuaki Oda, Mika Tadokoro, Shunsuke Yuba, Hajime Ohgushi, Takeshi Taketani, and Takumi Era
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan; Health Research Institute,
National Institute of Advanced Industrial Science and Technology, Hyogo, Japan; Division of Blood Transfusion, Shimane
University Hospital, Shimane, Japan

28
Influence of chronic glucocorticoid exposure on proliferation and differentiation of rat neuralstem cells in vitro
Haruki Odaka, Tadahiro Numakawa, Aya Yoshimura, Naoki Adachi, Shingo Nakajima, Takumi Era,
Takafumi Inoue, Hiroshi Kunugi
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry,Tokyo, Japan; Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda
University Tokyo, Japan; Division of Laboratory Animals Resources, National Institute of Neuroscience, National Center of
Neurology and Psychiatry Tokyo, Japan; Department of Cell Modulation, Institute of Molecular Embryology and Genetics,
Kumamoto University, Kumamoto, Japan.

29
A cost effective intestinal epithelial differentiation system from human iPS cells
Soichiro Ogaki, Mayu Morooka, Kaito Otera and Shoen Kume
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

30
Actin cytoskeleton dynamics links Rho signaling with Yap/Taz to support human ES cell survival
Masatoshi Ohgushi, Maki Minaguchi and Yoshiki Sasai
Human StemCell Technology, CDB, RIKEN, Japan

31
Tsukushi maintains the growth and undifferentiated properties of neuronal stem/progenitor
cells
Kunimasa Ohta, Naofumi Ito, Felemban Athary Abdulhaleem M, Yohei Shinmyo, Hideaki Tanaka, andAyako Ito
Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan

32
Intra-Cellular Signaling pathways affected by the Genetic background in mouse embryonic stem
cells
Satoshi Ohtsuka and Hitoshi Niwa
Lab. For Pluripotent Stem Cell Studies RIKEN CDB, Kobe, Japan33
The effect of optimized weak current on Alzheimer’s Disease pathology
Go Okita and Hirofumi Kai
Department of Molecular Medicine, Kumamoto University, Kumamoto, Japan

34
Structural basis of disulfide bond formation in the mammalian endoplasmic reticulum
Masaki Okumura1, Kentaro Noi2,3, Shoji Masui1, Shingo Kanemura1, Teru Ogura2,3, and Kenji Inaba1,3
1Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan; 2Institute of Molecular
Embryology and Genetics, Kumamoto University, Kumamoto, Japan, 3CREST, JST

35
Visualization of dynamics of the 26S proteasome and protesome-substrate complexes byhigh-speed AFM
Takashi Okuno1,5, Kentaro Noi2,5, Akiko Okawa2, Hikaru Tsuchiya3, Yasushi Saeki3, Kazunobu
Takahashi4, Tomonao Inobe4, Kunitoshi Yamanaka2,5 and Teru Ogura2,5
1Fac. Sci., Yamagata Univ.; 2Inst. Mol. Embryol. Genet., Kumamoto Univ.; 3Lab. of Protein Metab., Tokyo Metro. Inst. ofMed. Sci.; 4Frontier Res. Core for Life Sci., Univ. of Toyama; 5CREST, JST.

36
Characterization of the Intracellular Behavior of COL4A5 and Clarification of Molecular
Mechanism of Alport Syndrome
K Omachi, M Kamura, K Teramoto, R Fukuda, Y Kai, M A Suico, T Shuto, and H Kai
Department of Molecular Medicine, Kumamoto University, Kumamoto, Japan37
Easy purification of human iPSC-derived immature intestinal epithelial cells
Kaito Otera, Soichiro Ogaki, Shoen Kume
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

38
Draxin from neocortical neurons controls thalamocortical projections into the neocortex
M. Asrafuzzaman Riyadh1, Yohei Shinmyo1,2, Giasuddin Ahmed1, Iftekhar Bin Naser1, Mahmud
Hossain1, Kunimasa Ohta1, Hideaki Tanaka1

1
Dep. Dev. Neurobiol., Grad. Sch. Life Sci., Kumamoto Univ.; 2Department of Biophysical Genetics, Graduate School of
Medical Sciences, Kanazawa University

39
Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes
Hiroshi Sakamoto1, Naoki Takeda2, Fumio Arai3, Kentaro Hosokawa3, Paloma Garcia4, Toshio Suda3,
Jon Frampton4, and Minetaro Ogawa1

1
Dep. Cell Diff., IMEG, Kumamoto Univ., Kumamoto City, Japan; 2Div. Transgen. Tech., IRDA, Kumamoto Univ.,
Kumamoto City, Japan; 3Dep. Cell Diff., School of Medicine, Keio Univ., Tokyo, Japan; 4Col. Med. Dent. Science, Inst.
Biomedical Research, Univ. Birmingham, Birmingham, UK

40
Monoamine mediating signals control the late-stage pancreatic beta cell differentiation
Daisuke Sakano1, Nobuaki Shiraki1, Kazuhide Kikawa1,2, Taiji Yamazoe1, Masateru Kataoka1, Kahoko
Umeda1,5, Kimi Araki3, Shirou Matsumoto2, Naomi Nakagata4, Fumio Endo2, Kazuhiko Kume1,6,Motonari Uesugi7 and Shoen Kume1,5
1

IMEG, Kumamoto Univ.; 2Graduate School of Medical Sciences, Kumamoto Univ.; 3IRDA, Kumamoto Univ.; 4CARD,
Kumamoto Univ.; 5HIGO Program, Kumamoto Univ.; 6Graduate School of Pharmaceutical Sciences, Nagoya City Univ.;
7
IWPI-iCeMS, Kyoto Univ.

41
Adipose tissue-derived peptide, CCHamide-2, controls the secretion and synthesis of Insulin in
Drosophila melanogaster
Hiroko Sano1, Akira Nakamura2, Hiroshi Ishimoto3, Azusa Kamikouchi3, Michael Texada4, Jim
Truman4,5, and Masayasu Kojima1
1

Department of Molecular Genetics, Institute of Life Sciences, Kurume University, Kurume, Japan; 2Institute of Molecular
Embryology and Genetics, Kumamoto University, Kumamoto, Japan; 3Graduate School of Science, Nagoya University,
Nagoya, Japan; 4Janelia Farm Research Campos, Ashburn, VA, USA; 5Howard Hughes Medical Institute, USA.

42
Tead and Myc cooperatively regulate cell competition in mammalian cells
Takashi Sato, Hiroshi Mamada, and Hiroshi Sasaki
Department of Cell Fate Control, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan43
PRDM14 accelerates reversion of EpiLCs to ESCs through the TET-BER-dependent active
demethylation
Naoki Okashita and Yoshiyuki Seki
Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan44
Establishment of disease model using induced pluripotent stem cells derived from Niemann-Pickdisease type C
Minami Soga1, Makoto Hamasaki1, Kaori Yoneda2, Kimitoshi Nakamura2, Muneaki Matsuo3, Tetsumi
Irie4, Fumio Endo2, and Takumi Era1
1

Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan;
Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; 3Department ofPediatrics, Saga University, Faculty of Medicine, Saga, Japan; 4Department of Clinical Chemistry and Informatics, Graduate
School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan2

45
Sexually dimorphic gene, MafB, regulates masculinization of the external genitalia
Kentaro Suzuki and Gen Yamada
Department of Developmental Genetics, Institute of Advanced Medicine, Wakayama Medical University (WMU), Kimiidera,
Wakayama, Japan46
The role of thalamic afferent-derived factors in cortical development
Haruka Sato-Takemoto1, Jun Hatakeyama1, Nobuhiko Yamamoto2 and Kenji Shimamura1
1

Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan; 2Graduate School of Frontier
Biosciences, Osaka University, Suita, Japan47
The role of Foxo1 transcription factor in vascular development
Kiyomi Tsuji-Tamura and Minetaro Ogawa
Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto,
Japan

48
Sall4 is essential for mouse primordial germ cell specification by suppressing the somatic cell
program genes
Satomi S. Tanaka, Yasuka L. Yamaguchi and Ryuichi Nishinakamura
Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto,
Japan

49
Development of culture method for maintenance of rat metanephric mesenchyme progenitor
cells
Shunsuke Tanigawa1,2, Nirmala Sharma3, Terry P. Yamaguchi3, Ryuichi Nishinakamura1,2 and Alan O.
Perantoni3
1

Department of Kidney Development, Institute of Molecular Embryology and Genetics, 2Program for leading graduate
schools, HIGO program, Kumamoto University, Kumamoto 860-0811, Japan; 3Cancer and Developmental Biology
Laboratory, Center for Cancer Research, Frederick National Laboratory for Cancer Research, MD, USA.

50
Possible mechanism of tumor suppression via Chk2-directed mitotic cell death
Yuki Tanoue and Satoshi Tateishi
Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

51
INCREASED IL-17C PRODUCTION BY THE TLR3 LIGAND POLY(I:C) IN PRIMARYCYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS
Yukihiro Tasaki1, Keiko Ueno-Shuto2, Tsuyoshi Shuto1, Shunsuke Kamei1,3, Onuki Kouhei1, Mary Ann
Suico1, Hirofumi Kai1,31Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University; 2Laboratory of
Pharmacology, Sojo University Pharmacy School, Kumamoto 860-0082, Japan; 3Program for Leading Graduate Schools“HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto University

52
A subpopulation of EpCAM-positive cancer cells is involved in chemoresistance and prevents
platinum anticancer drug-induced apoptosis in epithelial ovarian cancer
Shingo Tayama, Takeshi Motohara, Francisca Tjhay, Dashdemberel Narantuya, Isao Sakaguchi,
Hironori Tashiro, Hidetaka Katabuchi
Department of Obstetrics and Gynecology Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan

53
Involvement of CD44 variant, a cancer stem cell marker, in peritoneal metastasis and poor
prognosis in patients with epithelial ovarian cancer
Francisca Tjhay, Takeshi Motohara, Shingo Tayama, Dashdemberel Narantuya, Isao Sakaguchi,
Hironori Tashiro, Hidetaka Katabuchi
Department of Obstetrics and Gynecology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan54
Low-intensity direct electrical current stress suppresses pro-inflammatory cytokines expression
via inhibition of multiple signaling pathways
Yu Tsurekawa, Ihori Shitanda, Shingo Matsuyama, Kazunori Mitsutake, Ryosuke Fukuda, Yukari Kai,
Mary Ann Suico, Tsuyoshi Shuto, Hirohumi Kai
Institute of Molecular Medicine, Kumamoto University, Kumamoto, Japan

55
S-adenosylmethionine is crucial for maintaining human pluripotent stem cells
Tomonori Tsuyama1,3, Nobuaki Shiraki1, Yasuko Shiraki2, Fumiaki Obata4,5, Masayuki Miura4,5,Kazuhiko Kume1,6, Fumio Endo2 and Shoen Kume1,3
1

Department of Stem Cell Biology, Institute of Molecular Embryology and Genetics, Kumamoto Univ., Kumamoto, Japan;
Department of Pediatrics, Graduate School of Medical Sciences, Kumamoto Univ., Kumamoto, Japan; 3Program for
Leading Graduate Schools ‘‘HIGO,’’ Kumamoto Univ., Kumamoto, Japan; 4Department of Genetics, Graduate School of
Pharmaceutical Sciences, The Univ. of Tokyo, Tokyo, Japan; 5CREST, Japan Science and Technology Agency, Tokyo,
Japan; 6Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City Univ., Nagoya, Japan
2

56
The role of Non-Specific transcription factor in Pluripotent Network
Hiroki Ura and Hitoshi Niwa
Laboratory for Pluipotent Cell Studies, RIKEN Center for Developmental Biology (CDB)57
Smad4 is dispensable for self-renewal of mouse embryonic stem cells
Mariko Yamane and Hitoshi Niwa
Laboratory for Pluripotent Stem Cell Studies, RIKEN CDB, Japan

58
Apoptosis-specific p53 co-activator, Aspp1 induces apoptosis in damaged hematopoietic stem
cells and prevents malignant transformation
Masayuki Yamashita, Eriko Nitta and Toshio Suda
Department of Cell Differentiation, the Sakaguchi Laboratory of Developmental Biology, Keio University School of
Medicine, Tokyo Japan59
The nucleocytoplasmic transport system that regulates the cell fate in stem cells and embryos
Noriko Yasuhara
National Institute of Biomedical Innovation, Osaka, Japan60
Functional Analysis of TGF-b signaling pathway in hepatoblasts during mouse hepatic
histogenesis
Yuji Yokouchi1, Naoki Takeda1, Hiroshi Sasaki2, and Ken-ichi Yamamura1

1
Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan; 2Institute of Molecular
Embryology and Genetics, Kumamoto University, Kumamoto, Japan61
FAM105A modulates the inflammatory response to lipopolysaccharide
Tsubasa Yokota, Ryosuke Fukuda, Mary Ann Suico, Tsuyoshi Shuto, Hirofumi Kai
Department of Molecular Medicine, Kumamoto University, Kumamoto, Japan

62
Significance of SOX9 gene for transdifferentiation of hepatocyte in liver
Daiki Yoshii1, Yuji Yokouchi2, Hiroko Suda1 and Yukihiro Inomata1
1

Department of Pediatric Surgery and Transplantation, Graduate school of Medical Sciences, Kumamoto University,
Kumamoto, Japan; 2Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan63
The effect of IL-6 on expression of microRNAs in rat embryonic neural stem cells during theirdifferentiation
Aya Yoshimura1, Tadahiro Numakawa2, Haruki Odaka2, Yoshitaka Tamai1, Takumi Era3, and Hiroshi
Kunugi2
1

Division of Laboratory Animal Resources, National Institute of Neuroscience, National Center of Neurology and Psychiatry,Tokyo, Japan; 2Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology
and Psychiatry, Tokyo, Japan; 3Department of Cell Modulation, Institute of Molecular Embryology and Genetics, Kumamoto
University, Kumamoto, Japan.