Blood Pressure Monitor “PASESA”
new oscillometric device with AVI&API

PASESA

Prevent ArterioSclerosis and Enjoy Successful AgingPASESA, digital blood pressure monitorfor medical use■ Sit still for two minutes and you can check the condition (elasticity) of your bloodvessels, while measuring your blood pressure at the same time.
■ We developed this Japan’s original technology with the collaboration of National
Institute of Advanced Industrial Science and Technology and RIKEN, the Institute ofPhysical and Chemical Research.
■ PASESA is useful and effective in preventing arteriosclerosis.
■ PASESA has obtained marketing approval required by Japanese Pharmaceutical
Affairs Law, and is now used mainly in university hospitals.

Principle of AVI （Arterial Velocity pulse Index)
Principle: AVI shows the characteristics of the pulse waveform when the cuff pressure is higher than maximum bloodpressure. RIKEN recently found that the pulse waves in pressure area which has usually been ignored represent
the stiffness and the nature of the central arteries near the heart. Due to aging and arteriosclerosis, the waveformchanges (from left to right in below patterns). The upper waveforms are those of cuff pressure pulse wave, andthe lower are the differentiated waveforms (differentiated pulse wave). Aging, arteriosclerosis and increased
peripheral vessel resistance increase the reflected wave, which in turn increase telesystolic waveforms (P2) andresult in a sharp fall of waveform. Since the waveform is unaffected by the reflected wave at the beginning (P1),
only Vr of differentiated pulse wave amplitude increases. Thus the value of the characteristics of the pulsewaveform (Vr/Vf) becomes the index that changes according to the size of the reflected wave.
Definition: Calculate the ratio of the speed changes
at upper arm artery during systolic period(Vf) and diastolic period (Vr) (Vr/Vf).
AVI = 20 x (Vr/Vf)
Characteristics: The value of AVI increases byfactors which increase the reflected wave
(aging, arteriosclerosis and increased
peripheral vessel resistance)

P2
P1
International Journal of Cardiology Available online 17 March 2015
「The accuracy of central blood pressure waveform by novel ｍａｔｈｅｍａｔｉｃａｌ transformation of noninvasive measurement」

Principle of API (Arterial Pressure volume Index)
Principle: The more elastic the arteries, the more drastic the arterial
volume changes when the cuff pressure decreases. The bloodvessel stiffness is converted into numerical values using thegradient of the curve as index.
Definition: It calculates the relation between cuff pressure and arterial
volume from cuff pressure data, and approximate it to an
arctangent function (A*arctan(B*X+C)+D). API＝1/B
Characteristics: Reportedly, API represents the condition of
peripheral (upper arm) artery, and the value of API increases
by aging and arteriosclerosis.

Note theexpansion of
upper arm artery

Onset of arteriosclerosis has been rapidly increasing in areas
affected by the Great East Japan Earthquake
PASESA has been useful in physical examinations for detecting
economy-class syndrome (deep vein thrombosis)
63rd JAMT Congress 2014 Luncheon Seminar May 18 2014
“Arteriosclerosis among victims of the Great East Japan Earthquake: a possible
new method for detecting arteriosclerotic disease”
by Kazuhiko Hanzawa, MD, PhD, Division of Thoracic and Cardiovascular
Surgery, Niigata University Graduate School of Medical and Dental Sciences“According to the measurement results by PASESA, people living intemporary housings where they have easier access to medical facilities
are in better physical condition.”

PASESA Printed report of detailed measurement result (A4)
For doctors

Pulse wave
amplitude graph
Velocity pulse
wave graph
Pulse wave
graph (Pulse
wave chart)
Blood vessel
index
referencevalue graphFor examinees

HistorygraphBloodpressure
Pulse
Categories
AVI / of bloodpressureAPIhttp://www.riken.jp/en/outreach/transfer/products/