MACULAR EDEMA FOLLOWING BRANCH OR
CENTRAL RETINAL VEIN OCCLUSION (RVO)
AND TREATMENT WITH OZURDEX®

Approved Use
OZURDEX® (dexamethasone intravitreal implant) is aprescription medicine that is an implant injected into theeye (vitreous) and used to treat adults with swelling of
the macula (macular edema) following branch retinal veinocclusion (BRVO) or central retinal vein occlusion (CRVO).
IMPORTANT SAFETY INFORMATION
When Not to Use OZURDEX®
OZURDEX® should not be used if you have any
infections in or around the eyes, including most viraldiseases of the cornea and conjunctiva, including active
herpes viral infection of the eye, vaccinia, varicella,
mycobacterial infections, and fungal diseases.
Please see additional Important Safety
Information throughout.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf.

HOW CAN RVO
AFFECT MY EYES?

• Affects aboutONE

OUT OF EVERY

100people in a
5-year period• More likely in people

MIDDLE-AGED and OLDER

2ND MOSTCOMMON CAUSE

If you have certain health conditions,
your risk of branch retinal vein occlusion(BRVO) or central retinal vein occlusion(CRVO) can be higher. These conditions
include:• Hypertension (high blood pressure)• Diabetes mellitus• Glaucoma
RVO can recur, so it’s important to manage
your overall health as well as your eye healthto help reduce your risk of losing vision• Get treatment promptly forvision problems• Continue regular eye exams• Take careof your overallhealthof potential visual loss due to retinal
blood vessel disease23

WHAT IS RVO?
This may be caused by:Blood circulating through the retina leaves
the eye by draining into the retinal vein
• A retinal vein occlusion is a blockagethat prevents normal blood flow out ofthe eye• A blockage may affect the main veinleaving the eye (CRVO) or one of thesmaller, branch veins that lead to themain vein (BRVO)
Macular edema occurs when fluid leaks
from damaged blood vessels, causing themacula to swell.

• A blood clot
• Compression from a retinal artery• Diseases that affect blood vessels,such as– Diabetes– High eye pressure (glaucoma)– High blood pressure– Hardening of the arteries(arteriosclerosis)

ScleraChoroid

Branch retinal veins
MaculaFovea
Central retinalvein

Central retinal
artery4RetinaSwelling ofthe macula

The macula is the center of the retina andis responsible for sharp, central vision.
Untreated RVO can potentially leadto permanent vision impairment

5HOW CAN RVO
AFFECT MY VISION?
Sudden blurring or vision loss in all orpart of one eye are most common.

Blurry vision

These images are depictions only. Actual
visual symptoms vary for individuals.
• For some patients, the vision loss maylast for a few seconds or minutes or may
be permanent• The amount of blurring or vision loss
depends on how much damage to theretina has occurred
Swelling due to RVO can cause yourvision to change slowly, so you might noteven notice any symptoms. It’s importantto get your eyes checked regularly as
recommended by your doctor.
What can you do to prevent or delay
loss of vision due to macular edema
following RVO?

Floaters

Good management of any
health conditions, like diabetes,hypertension, and/or glaucoma
Regulareyeexams

Appropriate
follow-up

Vision loss

67

WHAT IS VISUAL ACUITY AND
HOW DOES IT RELATE TO RVO?

Visual acuity is the sharpness of yourvision. It is measured by the ability toread letters on an eye chart. What you
can see on the eye chart from 20 feetaway is recorded as a number.

20/40

20/20

You might have heard people refer to
20/20 vision as “perfect vision.” In fact,
a person with 20/20 vision can see what
an average person sees on an eye chartwhen standing 20 feet away.
Likewise, 20/40 vision means that, when
standing 20 feet away, the person can see
as well as an average person standing
40 feet away. On the eye chart to the left,
this means a person with 20/40 vision canread the letters in the line labeled 20/40
and above, but not the letters below.
• As vision worsens, the second
number increases• In 46 states, you needat least 20/40 vision
to obtain adriver’s license
Macular edema
following BRVO orCRVO can worsen
your visual acuity,
but treatment may
help improve it.

A TYPICAL EYE CHART

89HOW WILL MY RVOBE TREATED?

There are several
treatment options
for RVOYour doctor will determine which is mostappropriate for you and your RVO. Theseoptions include:• Laser treatment• Anti-VEGF injections into the eye• Steroid injections into the eye– One type is an anti-inflammatory
injection, like OZURDEX®
(dexamethasone intravitreal implant)

IMPORTANT SAFETY INFORMATION (continued)
When Not to Use OZURDEX® (dexamethasone
intravitreal implant) (continued)
OZURDEX® should not be used if you have glaucoma
that has progressed to a cup-to-disc ratio of greaterthan 0.8.
OZURDEX® should not be used if you have a posteriorlens capsule that is torn or ruptured.
OZURDEX® should not be used if you are allergic
to any of its ingredients.
10What is OZURDEX®?
OZURDEX® is a tiny implant that
releases an anti-inflammatory agent (acorticosteroid) called dexamethasone
and is approved by the U.S. Food andDrug Administration (FDA) to treat adults
with macular edema following BRVO orCRVO. It can help reduce inflammation
in your retina and swelling in the macula.
It is injected into the back of the eye,with minimal absorption into your body.
Your doctor will decide when and if areinjection of OZURDEX® is needed.
OZURDEX® IMPLANT SIZE COMPARISON
Implant*

Grain of rice

*Actual size

Please see additional Important Safety
Information throughout.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf

11HOW WILL OZURDEX®
WORK INSIDE MY EYE?

OZURDEX® will be injected into thevitreous cavity in the back of your eye.
OZURDEX® treatment• Can help improve visual acuity(sharpness of vision)
The implant dissolves• Medication is slowly released
over time as OZURDEX® dissolves• In two 6-month clinical trials with BRVO
and CRVO patients, 427 received
OZURDEX® and 426 received sham(control) treatment• Patients treated with OZURDEX®
achieved ≥ 15 letters (3 lines) of vision
on an eye chart significantly faster thancontrol-treated patients• About 20% to 30% of those who
received OZURDEX® gained ≥ 15 lettersof vision on an eye chart within 1 to 2months, compared to 7% to 12% ofcontrol-treated patients• Once vision had improved, theimprovement lasted approximately
1 to 3 months• Your own individual results may vary;
talk to your doctor
SWOLLEN
MACULA

Please see additional Important Safety
Information throughout.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf
12A scan of a retina
with macular edema
following RVODECREASED
SWELLLING OF
THE MACULA

After treatment
with OZURDEX®

13

WHAT CAN I EXPECT WITH THE
OZURDEX® PROCEDURE?
AfterBefore• Speak with your doctor about anyquestions/concerns you may have• Arrange to have somebody take you toand from your appointment• Create a list of all the prescription andover-the-counter medications you take
During• The injection of OZURDEX® will only
take a few moments• You will be awake• Your doctor will clean and numb thesurface of the eye• Your doctor will inject OZURDEX® using
a special applicator that’s about the sizeof a pen• During the injection you may feelpressure on the eye• You may then hear a click when yourdoctor presses the button that releases
the OZURDEX® implant into your eye

14• Your doctor will check your eye, andthen you will be ready to go home• Over time, check for an improvement inyour vision. Your individual results may vary
• If your eye becomes red, sensitive tolight, painful, or develops a change invision, please contact your eye doctor
immediately• You may experience temporary visual
blurring after receiving an intravitreal
injection. Do not drive or use machines
until this has been resolved
Be sure to follow your doctor’s
instructions following the procedure.
IMPORTANT SAFETY INFORMATION (continued)
Warnings and Precautions
Injections into the vitreous in the eye, including
those with OZURDEX® (dexamethasone intravitrealimplant), are associated with serious eye infection(endophthalmitis), eye inflammation, increased eyepressure, and retinal detachments.
Please see additional Important Safety
Information throughout.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf

15WHAT SIDE EFFECTS CAN
HAPPEN WITH OZURDEX®?

OZURDEX® can cause cloudiness of
the lens that can lead to a cataract.

OZURDEX® can also cause your eye
pressure to increase.

• A cataract could form if you havemultiple treatments with OZURDEX®
• If that happens, your vision may
decrease, and you will need aprocedure to remove the cataract
and restore your vision– Ask your doctor about cataract
surgery. About 3.8 million surgeries
are performed in the United States
every year• In clinical trials, after 1 injection, cataracts
developed in about 7.3% out of 423
OZURDEX® patients and 4.5% out of
422 sham (control)–treated patients• Your doctor will monitor youreye pressure• If there is an increase in eye pressure,then your doctor may prescribe you aneye drop that will need to be used daily• In rare cases, the increase in eye
pressure may require surgery. In mostcases, the prescription eye drops willtake care of the increased pressure• In clinical trials, increased eye pressure
occurred in about 4% of 421 OZURDEX®
patients and 0.7% of 423 sham (control)–treated patients

IMPORTANT SAFETY INFORMATION (continued)
Warnings and Precautions (continued)
Your eye doctor should monitor you regularly after
the injection. Use of corticosteroids including
OZURDEX® (dexamethasone intravitreal implant) may
produce posterior subcapsular cataracts, increased
eye pressure, glaucoma, and may increase theestablishment of secondary eye infections due tobacteria, fungi, or viruses.
16

IMPORTANT SAFETY INFORMATION (continued)
Warnings and Precautions (continued)
Let your doctor know if you have a history ofocular herpes simplex as corticosteroids are notrecommended in these patients.
Please see additional Important Safety
Information throughout.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf

17WHAT PATIENT ASSISTANCERESOURCES ARE AVAILABLE?

How can I save on OZURDEX®
(dexamethasone intravitreal implant)
treatment?

Will my insurance cover OZURDEX®?
Ask your doctor’s office to verify coveragethrough your specific insurance carrier.

AbbVie is committed to helping patientsgain access to and afford treatments.
There are cost-savings opportunities
available for OZURDEX®.
If you have commercial insurance andmeet other eligibility requirements, you
can pay as little as $0 for OZURDEX®.
Ask your doctor if you qualify. If you
are eligible, your doctor will enroll you.
IMPORTANT SAFETY INFORMATION (continued)
Common Side Effects in Retinal Vein Occlusion
The most common side effects reported include:
increased eye pressure, conjunctival blood spot,
eye pain, eye redness, ocular hypertension, cataract,
vitreous detachment, and headache.
Patient Counseling Information
After repeated injections with OZURDEX®
(dexamethasone intravitreal impant), a cataract mayoccur. If this occurs, your vision will decrease andyou will need an operation to remove the cataract
and restore your vision. You may develop increased
eye pressure with OZURDEX® that will need to be
managed with eye drops, and rarely,with surgery.
18

IMPORTANT SAFETY INFORMATION (continued)
Patient Counseling Information (continued)
In the days following injection with OZURDEX®, you
may be at risk for potential complications including
in particular, but not limited to, the development ofserious eye infection or increased eye pressure. If
your eye becomes red, sensitive to light, painful,or develops a change in vision, you should seek
immediate care from your eye doctor. You may
experience temporary visual blurring after receiving aninjection and should not drive or use machinery until
your vision has resolved.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf

19

LEARN MORE ABOUT OZURDEX®
AND RVO AT OZURDEX.COM

Please see Important Safety Informationthroughout.
Please see accompanying full Prescribing
Information or visit https://www.rxabbvie.com/pdf/ozurdex_pi.pdf© 2023 AbbVie. All rights reserved.
All trademarks are the property of their respective owners.
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