東京大学医学部附属病院 小児科 総合診療チーム

業績
2022年
1. Case report: Autonomic and endocrine response in the process of brain death in a child with hypoxicischemic brain injury. Hayashi K, Uchida K, Ota H, Tanaka H, Maezawa M, Matsui H. Front Pediatr.
2022 Jul 22;10:954651.
2. Biallelic ADAM22 pathogenic variants cause progressive encephalopathy and infantile-onset
refractory epilepsy. van der Knoop MM, Maroofian R, Fukata Y, van Ierland Y, Karimiani EG,Lehesjoki AE, Muona M, Paetau A, Miyazaki Y, Hirano Y, Selim L, de França M, Fock RA, Beetz C,Ruivenkamp CAL, Eaton AJ, Morneau-Jacob FD, Sagi-Dain L, Shemer-Meiri L, Peleg A, HaddadHalloun J, Kamphuis DJ, Peeters-Scholte CMPCD, Kurul SH, Horvath R, Lochmüller H, Murphy D,Waldmüller S, Spranger S, Overberg D, Muir AM, Rad A, Vona B, Abdulwahad F, Maddirevula S,Povolotskaya IS, Voinova VY, Gowda VK, Srinivasan VM, Alkuraya FS, Mefford HC, Alfadhel M,Haack TB, Striano P, Severino M, Fukata M, Hilhorst-Hofstee Y, Houlden H. Brain 145: 2301-2312,20223. Critical brainstem encephalitis/encephalopathy in a child with COVID-19. Kunikata A, Hayashi K,Kinumaki A, Akatsuka Y, Shimoda K, Kato M, Matsui H. Pediatr Int. 64：e15353, 2022
4. Circulating nephrin autoantibodies and posttransplant recurrence of primary focal segmental
glomerulosclerosis. Hattori M, Shirai Y, Kanda S, Ishizuka K, Kaneko N, Ando T, Eguchi M, Miura K.
Am J Transplant. 2022 Oct;22(10):2478-2480. doi: 10.1111/ajt.17077.
5. Urinary extracellular vesicles signature for diagnosis of kidney disease. Takizawa K, Ueda K,Sekiguchi M, Nakano E, Nishimura T, Kajiho Y, Kanda S, Miura K, Hattori M, Hashimoto J,Hamasaki Y, Hisano M, Omori T, Okamoto T, Kitayama H, Fujita N, Kuramochi H, Ichiki T, Oka A,Harita Y. iScience. 2022 Nov 8;25(11):105416. doi: 10.1016/j.isci.2022.105416.
6. 腹膜刺激症状を伴う腹痛を初発症状とした不全型川崎病および既報例のまとめ. 北岡寛己,梶保祐子, 大和田啓峰, 大橋瑛梨, 高橋千恵, 神田祥一郎, 張田豊, 岡明. 日本小児科学会雑誌
126(9): 1287-1297, 2022
7. 重症貧血を伴う心不全の原因検索中に判明した自己瀉血. 平野瑶子, 絹巻暁子, 梶保祐子, 高橋千恵, 神田祥一郎, 加藤元博. 日本小児科学会雑誌 126(11): 1505-1511, 2022

8. 呼吸障害を契機に診断されたダンベル型甲状舌管嚢胞の2ヵ月女児. 入江紗瑛子, 絹巻暁子,

田中裕之, 高橋千恵, 大和田啓峰, 梶保祐子, 神田祥一郎, 前澤身江子, 松井彦郎, 張田豊. 小児科臨床 75(6): 1001-1005, 2022
2021年
1.

A novel de novo truncating TRIM8 variant associated with childhood-onset focal segmental
glomerulosclerosis without epileptic encephalopathy: a case report. Shirai Y, Miura K, Kaneko
N, Ishizuka K, Endo A, Hashimoto T, Kanda S, Harita Y, Hattori M. BMC Nephrol. 2021 Dec
20;22(1):417. doi: 10.1186/s12882-021-02626- 1.

2.

An infant with X-linked anhidrotic ectodermal dysplasia with immunodeficiency presenting
with Pneumocystis pneumonia: A case report. Toyohara M, Kajiho Y, Toyofuku E, Takahashi
C, Owada K, Kanda S, Harita Y, Ohnishi H, Wada T, Imai K, Kanegane H, Morio T, Oka A.
Clin Case Rep. 2021 Nov 16;9(11):e05093. doi: 10.1002/ccr3.5093.

3.

A case of early onset cystinuria in a 4-month-old girl. Ikeyama S, Kanda S, Sakamoto S, Sakoda
A, Miura K, Yoneda R, Nogi A, Ariji S, Shimoda M, Ono M, Kanda S, Yokoyama S,Takahashi K, Yokoyama Y, Hattori M. CEN Case Rep. 2021 Oct 20. doi: 10.1007/s13730-02100655-1.

4.

Cancer After Pediatric Kidney Transplantation: A Long-term Single-center Experience in Japan.
Yabuuchi T, Miura K, Shimizu S, Kaneko N, Ishizuka K, Kanda S, Chikamoto H, Akioka Y,Fujieda

M,HattoriM.

Transplant

Direct.

2021

Mar22;7(4):e687.

doi:

10.1097/TXD.0000000000001137.
5.

Combination therapy of continuous nebulization and high-flow nasal cannula for severecongenital tracheal stenosis. Ota H, Kanda S, Uchida K, Hayashi K, Maezawa M, Matsui H.
Pediatr Pulmonol. 2021 Dec;56(12):4055-4056. doi: 10.1002/ppul.25670.

6.

Response to steroid and immunosuppressive therapies may predict post-transplant recurrence ofsteroid-resistant nephrotic syndrome. Miura K, Ando T, Kanda S, Hashimoto T, Kaneko N,Ishizuka K, Hamada R, Hataya H, Hotta K, Gotoh Y, Nishiyama K, Hamasaki Y, Shishido S,Fujita N, Hattori M. Pediatr Transplant. 2021 Jul 26:e14103. doi: 10.1111/petr.14103.

7.

A case of 17q12 deletion syndrome that presented antenatally with markedly enlarged kidneys
and clinically mimicked autosomal recessive polycystic kidney disease. Nakamura M, Kanda
S, Kajiho Y, Morisada N, Iijima K, Harita Y. CEN Case Rep. 2021 Nov;10(4):543-548. doi:
10.1007/s13730-021-00604-y.

8.

SLC25A13 遺伝子ヘテロ接合性変異を有する胆汁うっ滞性肝障害の乳児例. 足立夏帆,高橋千恵, 田中裕之, 森口駿, 大橋瑛梨, 大和田啓峰, 梶保祐子, 神田祥一郎, 張田豊, 伊藤彰悟, 戸川貴夫, 高見尚平, 藤代準, 岡明. 小児科臨床 74(10): 1245-1249, 2021.

9.

Beckwith-Wiedemann 症候群の超早産児で多発乳児肝血管腫を合併した 1 例. 足立夏帆,
入佐千晴, 鹿島晃平, 垣内五月, 西村力, 高見尚平, 渡辺美穂, 高橋尚人. 日本周産期・新生児医学会雑誌. 2021 Sep;57(2):371-375. doi: 10.34456/jjspnm.57.2_371.

10. Kawasaki Disease and Vaccination: Prospective Case-Crossover Studies among Infants inJapan. Murata K, Onoyama S, Yamamura K, Mizuno Y, Furuno K, Matsubara K, Hatae K,Masuda K, Nomura Y, Ohno T, Kinumaki A, Miura M, Sakai Y, Ohga S, Fukushima W,Kishimoto J, Nakamura Y, Hara T. Vaccines 9: 839, 2021

2020 年1.

The Cellular Model of Albumin Endocytosis Uncovers Link Between Membrane and Nuclear
Proteins. Urae S, Harita Y, Udagawa T, Ode KL, Nagahama M, Kajiho Y, Kanda S, Saito A,Ueda HR, Nangaku M, Oka A. J Cell Sci. 2020 Jun 1:jcs.242859. doi: 10.1242/jcs.242859.

2.

Development of an exon skipping therapy for X-linked Alport syndrome with truncating
variants in COL4A5. Yamamura T, Horinouchi T, Adachi T, Terakawa M, Takaoka Y, Omachi K,Takasato M, Takaishi K, Shoji T, Onishi Y, Kanazawa Y, Koizumi M, Tomono Y, Sugano A,Shono A, Minamikawa S, Nagano C, Sakakibara N, Ishiko S, Aoto Y, Kamura M, Harita Y,Miura K, Kanda S, Morisada N, Rossanti R, Ye MJ, Nozu Y, Matsuo M, Kai H, Iijima K, Nozu
K. Nat Commun. 2020 Jun 2;11(1):2777. doi: 10.1038/s41467-020-16605-x.

3.

Incomplete cryptic splicing by an intronic mutation of OCRL in patients with partial phenotypesof Lowe syndrome. Nakano E, Yoshida A, Miyama Y, Yabuuchi T, Kajiho Y, Kanda S, Miura K,Oka A, Harita Y. J Hum Genet. 2020 May 19. doi: 10.1038/s10038-020-0773-3.

4.

Renal hypoplasia can be the cause of membranous nephropathy-like lesions. Takizawa K, Miura
K, Kaneko N, Yabuuchi T, Ishizuka K, Kanda S, Harita Y, Akioka Y, Horita S, Taneda S, Honda
K, Hattori M. Clin Exp Nephrol. 2020 May 19. doi: 10.1007/s10157-020-01902-y.

5.

Rituximab-induced serum sickness in a 6-year-old boy with steroid-dependent nephrotic
syndrome. Nakamura M, Kanda S, Yoshioka Y, Takahashi C, Owada K, Kajiho Y, Harita Y,Oka A. CEN Case Rep. 2020 Jan 22. doi: 10.1007/s13730-020- 00449-x.

6.

Deletion in the Cobalamin Synthetase W Domain-Containing Protein 1 Gene Is associated withCongenital Anomalies of the Kidney and Urinary Tract. Kanda S,Ohmuraya M, Akagawa H, Horita S, Yoshida Y, Kaneko N, Sugawara N, Ishizuka K, Miura K,Harita Y, Yamamoto T, Oka A, Araki K, Furukawa T, Hattori M. J Am Soc Nephrol.
2020;31(1):139-147. doi: 10.1681/ASN.2019040398.
→東京大学医学部附属病院 HP>最新の研究
https://www.h.u-tokyo.ac.jp/participants/research/saishinkenkyu/20200110

7.

森口駿, 神田祥一郎, 森貞直哉, 梶保祐子, 張田豊, 飯島一誠, 岡明：学校検尿を契機に診断されたPKHD1遺伝子変異を有する多発性嚢胞腎の1例. 小児科臨床 73：1316-1320,
2020.

2019 年
1.

Quantitative facial expression analysis revealed the efficacy and time course of oxytocin inautism. Owada K, Okada T, Munesue T, Kuroda M, Fujioka T, Uno Y, Matsumoto K,Kuwabara H, Mori D, Okamoto Y, Yoshimura Y, Kawakubo Y, Arioka Y, Kojima M, Yuhi T,Yassin W, Kushima I, Benner S, Ogawa N, Kawano N, Eriguchi Y, Uemura Y, Yamamoto M,Kano Y, Kasai K, Higashida H, Ozaki N, Kosaka H, Yamasue H. Brain. 2019 May 16. pii:
awz126. doi: 10.1093/brain/awz126.

2.

Quantification of speech and synchrony in the conversation of adults with autism spectrum
disorder. Ochi K, Ono N, Owada K, Kojima M, Kuroda M, Sagayama S, Yamasue H. PLoSOne. 2019 Dec 5;14(12): e0225377. doi: 10.1371/journal.pone.0225377. eCollection 2019.

3.

Paternal age contribution to brain white matter aberrations in autism spectrum disorder. Yassin
W, Kojima M, Owada K, Kuwabara H, Gonoi W, Aoki Y, Takao H, Natsubori T, Iwashiro N,
Kasai K, Kano Y, Abe O, Yamasue H. Psychiatry Clin Neurosci. 2019 Oct;73(10):649-659.
doi: 10.1111/pcn.12909. Epub 2019 Jul 30.

4.

Neuroanatomical Correlates of Advanced Paternal and Maternal Age at Birth in Autism
Spectrum Disorder. Kojima M, Yassin W, Owada K, Aoki Y, Kuwabara H, Natsubori T,Iwashiro N, Gonoi W, Takao H, Kasai K, Abe O, Kano Y, Yamasue H. Cereb Cortex. 2019 Jun
1;29(6):2524-2532. doi: 10.1093/cercor/bhy122.

5.

In Vivo Expression of NUP93 and Its Alteration by NUP93 Mutations Causing Focal Segmental
Glomerulosclerosis. Hashimoto T, Harita Y, Takizawa K, Urae S, Ishizuka K, Miura K, Horita
S, Ogino D, Tamiya G, Ishida H, Mitsui T, Hayasaka K, Hattori M. Kidney Int Rep. 2019 May
31;4(9):1312-1322. doi: 10.1016/j.ekir.2019.05.1157. eCollection 2019 Sep.