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ࠛ501-1193 ᒱ㜧ᕷᰗᡞ 1 ␒㸯E-mail : mgrc@gifu-u.ac.jp
TEL : 058-293-3171
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┠‫ ی‬ศ㔝㛗࠶࠸ࡉࡘḟ࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

ࢤࣀ࣒◊✲ศ㔝⫋ဨྡ⡙࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭㸦㸧ᑓ௵ᩍဨ
㸦㸧㠀ᖖ໅⫋ဨ㸦㸧◊✲ဨ

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

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 ௧࿴  ᖺᗘ฼⏝Ⓩ㘓⪅ཬࡧ◊✲ࢸ࣮࣐ࢤࣀ࣒◊✲ศ㔝ඹྠ฼⏝ᶵჾ⤂௓฼⏝ࡢᡭᘬࡁ

௧࿴  ᖺᗘάື≧ἣሗ࿌࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭࣭

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࣭࣭࣭࣭࣭࣭‫ ی‬ศ㔝㛗࠶࠸ࡉࡘࢤࣀ࣒◊✲ศ㔝㛗ᑵ௵࡟࠶ࡓࡾ
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᪤Ꮡศᯒ⿦⨨ࡢ᭦᪂ࡸ᪂つศᯒ⿦⨨ࡢᑟධࡀᚲせ࡜࡞ࡾࡲࡍࠋࢤࣀ࣒◊✲ศ㔝࡛ࡣ௧࿴㸱ᖺᗘᮎ࡟᪂ࡓ࡟࣐ࣝࢳ࣮ࣔࢻࣉ࣮ࣞࢺ࣮ࣜࢲ࣮㸦1LYR$OSKD6㸧ࢆᑟධ⮴ࡋࡲࡋࡓࠋࡲࡓࠊ᪂つཷクゎᯒࢧ࣮ࣅࢫࡢ㛤ᣅ࡟ࡶຊࢆධࢀ࡚ཧࡾࡲࡋࡓࠋ௧࿴㸲ᖺᗘ࠿ࡽࡣࠊࡇࢀࡲ࡛ࡢᩍဨ
㸱ྡࡀ㸰ྡࡢయไ࡟࡞ࡾࡲࡍࡀࠊࡇࢀࡲ࡛ྠᵝࠊྛ✀⏕࿨⛉Ꮫ◊✲ᨭ᥼ࡢせᮃ࡟ᛂ࠼ࡿ࡭ࡃ
ດࡵ࡚ཧࡾࡲࡍࠋ฼⏝⪅ࡢࡳ࡞ࡉࡲ᪉࡟࠾࠿ࢀࡲࡋ࡚ࡣᘬࡁ⥆ࡁࠊࡲࡔ฼⏝ࡉࢀࡓࡇ࡜ࡀ࡞࠸ ᪉ ࡟ ࠾ ࠿ ࢀ ࡲ ࡋ ࡚ ࡣ ୍ ᗘ ࣍ ࣮ ࣒ ࣌ ࣮ ࢪ

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ㄽ⌮ⓗ๰⸆ࢆ฼⏝ࡋࡓ࣮࢜ࢺࣇ࢓ࢪ࣮
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ࡍࡿᐟ୺㜵ᚚ࡟࠾ࡅࡿᢠయ౫Ꮡᛶ㈎㣗
ࡢᙺ๭ࡢゎ᫂
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ங㓟⳦ 7- ᰴࡢΰ㣵ᢞ୚࡟ࡼࡿస⏝
᳨ウ

ಖ೺⾨⏕ᡤ
㣗ရ⛉Ꮫ◊✲ᡤៅ୍㑻

3 ࢤࣀ࣒◊✲ศ㔝ඹྠ฼⏝ᶵჾ⤂௓(1) DNA 㛵㐃ᶵჾ

1-<2>-(1) ࣜ࢔ࣝࢱ࢖࣒ᐃ㔞 PCR
ABI Step One Plus࢔ࣉࣛ࢖ࢻࣂ࢖࢜ࢩࢫࢸ࣒♫1-<1>-(5) DNA 㓄ิゎᯒࢯࣇࢺ4 Ⰽ㸭96 ࢙࢘ࣝࣇ࢛࣮࣐ࢵࢺ࡛ࠊ⢭ᗘࡢ㧗࠸ᐃ㔞

SEQUENCHER

ࣜ࢔ࣝࢱ࢖࣒ PCR ࢆᐇ⌧ࠋFAM™/SYBR® GreenࠊGene Codes ♫VIC® /JOE™ࠊROX™ࠊTAMRA™࡞࡝ࡢ⺯ගⰍ⣲࢟ࣕࣆ࣮ࣛࣜࢩ࣮ࢣ

ࡀ᳨ฟ࡛ࡁࠊ㑇ఏᏊⓎ⌧ゎᯒࠊ⑓ཎ㑇ఏᏊࡢᐃࣥࢧ࣮ࠊḟୡ௦ࢩ࣮

㔞ࠊSNP ࢪ࢙ࣀࢱ࢖ࣆࣥࢢࠊࣉࣛࢫ/࣐࢖ࢼࢫ࣭࢔

ࢣࣥࢧ࣮(NGS)࠿ࡽ

ࢵࢭ࢖࡞࡝ࡢᐇ㦂ࡀ⏕ᡂࡉࢀࡓ DNA 㓄ฟ᮶ࡿࠋᚑ᮶ࡢಶయ

ิࢆゎᯒࡍࡿࢯࣇࢺ

࡝࠺ࡋࡢẚ㍑ࡢࡳ࡞࢙࢘࢔ࠋἼᙧࢆぢ࡞ࡀࡽࡢࢺ࣑ࣜࣥࢢࡸ࢔ࢵࢭࣥ

ࡽࡎࠊ㞟ᅋ㛫ࡢẚ㍑

ࣈࣝࠊ࣐ࣝࢳࣉࣝ࢔ࣛ࢖࣓ࣥࢺࡸ⣔⤫ᶞసᡂࡀྍ

ࢆ⾜࠺ࡇ࡜ࡀྍ⬟ࠋ⬟ࠋḟୡ௦ࢩ࣮ࢣࣥࢫࢹ࣮ࢱ࡟ࡘ࠸࡚ࡣ FastQC ࡟

2 ྎಖ᭷ࠋ

ࡼࡿ㓄ิṇ☜ᛶࡢ☜ㄆࡸ Velvet ࡟ࡼࡿ de novo ࢔ࢭࣥࣈࣜ࡞࡝ࡀྍ⬟ࠋ

1-<3>-(1) ᰾㓟⢭〇⿦⨨

1-<1>-(3) DNA ከᆺゎᯒࢯࣇࢺ

Maxwellࢪ࣮࣐ࣥࢵࣃ࣮

ࣉ࣓ࣟ࢞♫࢔ࣉࣛ࢖ࢻࣂ࢖࢜ࢩࢫࢸ࣒♫ᵝࠎ࡞ࢧࣥࣉࣝ࠿ࡽ Total RNA

DNA ࣇࣛࢢ࣓ࣥࢺ

ࡢᢳฟ⢭〇ࢆ⾜࠸ࡲࡍࠋࡢࢧ࢖ࢬࢥ࣮ࣝ࠿ࡽ

㧗ရ㉁ࡢ RNA ࢆ෌⌧ᛶⰋࡃᢳ࢔ࣞࣝࢥ࣮ࣝࢆ⾜࠺ฟ࡛ࡁࡲࡍࠋ

ࢪ࢙ࣀࢱ࢖ࣆࣥࢢࢯ
ࣇࢺ࢙࢘࢔ࠋ

ᖹᡂ 28 ᖺ 5 ᭶ᑟධࠋ1-<1>-(4) ࣐ࣝࢳ࢟ࣕࣆ࣮ࣛࣜ DNA ࢩ࣮ࢣࣥࢧ࣮

1-<3>-(2) ᰾㓟⢭〇⿦⨨

3500xL Genetic Analyzer

QuickGene-Auto12S

ࢧ࣮ࣔࣇ࢕ࢵࢩ࣮ࣕࢧ࢖࢚ࣥࢸ࢕ࣇ࢕ࢵࢡ♫ࢡࣛ࣎࢘♫㟁ẼὋື࢟ࣕࣆ࣮ࣛࣜࢆ

㧗⣧ᗘࠊ㧗཰㔞ࡢ DNA/RNA ᅇ཰

24 ᮏ⿦ഛࠋඛ㐍ⓗ࡞ ᗘྍ⬟ࠋ㧗࠸᰾㓟྾╔ᛶ࡜ᐜ᫆࡞⬺ไᚚᶵᵓ࡟ࡼࡾ ᗘࢥࣥࢺ╔ᛶࢆ᭷ࡍࡿ⊂⮬ࡢከᏍ㉁࣓ࣥࣈ

࣮ࣟࣝࡢ⢭ᗘࢆᨵၿࠋ

ࣞࣥࢆ౑⏝ࠋ

RFID㸦↓⥺ IC ࢱࢢ㸧ᢏ⾡࡛ᾘ⪖ရࡢࢹ࣮ࢱࡢ⟶⌮ࠋ
70 ศ࡛ 650 ሷᇶ×24 ヨᩱࡢศᯒࡀྍ⬟ࠋཷクゎᯒ࡟౑⏝ࠋ2 ྎಖ᭷ࠋ2016 ᖺࠊ2020 ᖺᑟධࠋ

1-<5>-(1) ࢚ࣞࢡࢺ࣏࣮ࣟࣞࢱ࣮

1-<3>-(5) ࣂ࢖࢜࢔ࢼࣛ࢖ࢨ࣮
2100 BioAnalyzer

Gene Pulser II࢔ࢪࣞࣥࢺࢸࢡࣀࣟࢪ࣮♫ࣂ࢖࢜ࣛࢵࢻ♫㏻ᖖࠊDNA ศᯒ࡛ࡣࢤࣝ㟁ẼὋືࠊࢱࣥࣃࢡ㉁ศ

࢚ࣞࢡࢺ࣏࣮ࣟࣞࢩࣙࣥ࡜ࡣࠊ㟁Ẽࣃࣝࢫ࡟ࡼࡾ▐ᯒ࡛ࡣ SDS-PAGE ࡛ᚓࡿ⤖ᯝࢆࠊᑓ⏝ࢳࢵࣉࢆ౑

㛫ⓗ࡟⣽⬊࡟✸Ꮝࡋ DNA ➼ࡢ㧗ศᏊࢆ⣽⬊࡟ᑟධ⏝ࡋ࡚▷᫬㛫ࠊ⡆༢࡟ᚓࡿࡓࡵࡢ⿦⨨(᭱኱ 12 ࢧࣥࡍࡿ᪉ἲࠋ኱⭠⳦ࢆࡣࣉࣝࡢᐃᛶ࠾ࡼࡧᐃ㔞ࡌࡵ࡜ࡍࡿ⣽⳦ࡢᙧ㉁ࡢࢹࢪࢱࣝࢹ࣮ࢱࢆ 30㌿᥮ࠊື᳜≀⣽⬊ࡢศ࡛ྲྀᚓྍ⬟)ࠋᢳฟࡋ

DNA ᑟධ࡟౑⏝ࠋࡓ RNA ࡢရ㉁ホ౯ࡶྍ⬟ࠋ

1-<5>-(2) 㑇ఏᏊᑟධ⿦⨨1-<3>-(6) ࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩ࣮ࣙࣥ࢜ࣈࣥ

Neon Transfection System

G2545A

Life Technologies – Invitrogen ♫࢔ࢪࣞࣥࢺࢸࢡࣀࣟࢪ࣮♫᰾㓟ࢆ့ங㢮⣽⬊࡬ᑟධࡍࡿ⿦⨨ࠋ ึ௦ᇵ㣴⣽⬊DNA ࣐࢖ࢡࣟ࢔ࣞ࢖ࡢࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩࣙࣥࡓ

ࡸᖿ⣽⬊࡜࠸ࡗࡓࢺࣛࣥࢫࣇ࢙ࢡࢩࣙࣥࡀ㞴ࡋ࠸ࡵࡢ࢖࣮ࣥ࢟ࣗ࣋ࢱࠋྲྀࡾእࡋྍ⬟࡞࣮ࣟࢱࣛࢵ

⣽⬊ࢆྵࡵࠊከࡃࡢ⣽⬊࡛᭱኱ 90%ࡢᑟධຠ⋡ࢆࢡࢆഛ࠼ࠊᅇ㌿㏿ᗘ࡜ࣁ࢖ᐇ⌧ࠋ 1 ᅇࡢ཯ᛂ࡛ 2×104 ಶ࠿ࡽ 6×106 ಶࡢ⣽⬊࡟ࣈࣜࢲ࢖ࢮ࣮ࢩࣙࣥ ᗘࡢࢺࣛࣥࢫࣇ࢙ࢡࢩࣙࣥྍ⬟ࠋ1 ✀㢮ࡢヨ⸆࡛࠶ࡽࡺタᐃࡀྍ⬟ࠋ᭱኱ 24 ಶࡢࡿࢱ࢖ࣉࡢ⣽⬊࡟౑࢜ࣜࢦ DNA ࣐࢖ࢡࣟ࢔ࣞ

⏝࡛ࡁࡿࠋ࢚ࣞࢡࢺ

࢖⏝ࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩࣙ

࣏࣮ࣟࣞࢩࣙࣥࡢ᮲

ࣥࢳࣕࣥࣂࢆᅛᐃྍ⬟ࠋ௳ࢆไ㝈࡞ࡃ᭱㐺໬ྍ⬟ࠋ
1-<6>-(1) ࣐ࣝࢳࣅ࣮ࢬࣂ࢖࢜࢔ࢵࢭ࢖⿦⨨1-<3>-(7) DNA ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼ࣮

Luminex

Array Scan࣑࣏ࣜ࢔♫࢔ࢪࣞࣥࢺࢸࢡࣀࣟࢪ࣮♫ᑡ㔞㸦㹼ȝ/㸧ࡢヨᩱࢆࡶ࡜࡟࣐࢖ࢡࣟࣅ࣮ࢬ࡜

Cy3ࠊCy5ࡢ஧Ⰽἲ࡜

ࣇ࣮ࣟࢧ࢖ࢺ࣓ࢺ࣮ࣜࢆ฼⏝ࡋ࡚᭱኱ 100 㡯┠ࡲ༢Ⰽἲ࡟ᑐᛂࡍࡿ㧗࡛ࢧ࢖ࢺ࢝࢖ࣥࡸࣜࣥ㓟໬ࢱࣥࣃࢡ㉁࡞࡝ࡢᐃ㔞ᶵ⬟ࢫ࢟ࣕࢼࠋゎീᐃࡀ࡛ࡁࡿᗘࡀ  ȝP࡛ 244K/ᯛ

SNPs ࡞࡝

࡞࡝ࡢ㧗ᐦᗘ࢔ࣞ࢖

DNAࠊmicroRNAࡢศᯒࡀྍ⬟ࠋࡢศᯒ࡞࡝࡟ࡶ฼⏝ྍ⬟ࠋ

1-<7>-(1) ࣃࣝࢫࣇ࢕࣮ࣝࢻࢤࣝ㟁ẼὋື⿦⨨(3) ගᏛ⣔ศᯒᶵჾCHEF-DRII
ࣂ࢖࢜ࣛࢵࢻ♫3-<1>-(1) ࣐ࣝࢳ⺯ගࢫ࢟ࣕࢼ࣮

ᩘⓒ࠿ࡽᩘ࣓࣮࢞࣋ࢫ௨ୖࡢ DNA ࡢࢩ࣮ࣕࣉ࡞ศ

Typhoon 9400

㞳ࡀྍ⬟ࠋࢡࣟࣔ

࢔࣐ࢩ࣒ࣕࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫ࢰ࣮࣒࣐ࢵࣆࣥ

ᨺᑕᛶྠ఩య࡜⺯ගࠊࢣ࣑࣑ࣝࢿࢵࢭࣥࢫࡢ 3 ࡘࡢ

ࢢࠊRFLP ศᯒࠊࢫ࣮࢟ࣕࣥࣔࢻ࡜ࠊ㧗࠸ឤᗘ࡜ゎീᗘ࡟ࡼࡿ࣐࢖ࢡ

ࢪ࣮࣐ࣥࢵࣆࣥࢢ

ࣟ࢔ࣞ࢖ゎᯒࠊࣇࣛ

➼࡟౑⏝ࠋࢢ࣓ࣥࢺゎᯒࡸࠊ஧
ḟඖ㟁ẼὋືゎᯒ

1-<8>-(1) UV ࢡࣟࢫ࣮ࣜࣥ࢝

➼࡟ᑐᛂࠋ

GS Gene Linker
BioRad ♫ࢼ࢖࣓ࣟࣥࣥࣈࣞࣥ࡟ࢺࣛࣥࢫࣇ࢓࣮ࡋࡓ

3-<2>-(1),(2) ࣐ࣝࢳࣛ࣋ࣝࣉ࣮ࣞࢺ࣮ࣜࢲ࣮

DNA/RNAࢆᅛᐃࡍࡿ

Wallac 1420 ARVOsx (1)⿦⨨ࠋDNAࢽࢵ࢟ࣥ

Wallac 1420 ARVO SX-DELFIA (2)ࢢࡸ UV⁛⳦ࡶྍ⬟ࠋࣃ࣮࢚࣐࣮࢟ࣥࣝࣛ࢖ࣇࢧ࢖࢚ࣥࢫ♫ẅ⳦ࣛࣥࣉࡣ8࣡ࢵ

1420 ARVOsx ࡣ 96 ࢙࢘ࣝࣉ࣮ࣞࢺࢆࡣࡌࡵࠊᵝࠎ

トᆺ࣭Ἴ㛗 253.7nmࠋࣉ࣮ࣞࢺࢆ⏝࠸࡚⺯ගࠊⓎගࠊ⺯ග೫ගࢆࣁ࢖ࢫࣝ
࣮ࣉࢵࢺ࡛ ᐃྍ⬟ࠋ96ࠊ384ࠊ1536 ࢙࢘ࣝᶆ‽ࣉ
࣮ࣞࢺࠊ6ࠊ12ࠊ24ࠊ48 ࢙࢘ࣝᇵ㣴ࣉ࣮ࣞࢺ࡟ᑐᛂࠋ
ARVOsx-DELFIA ࡣ᫬㛫ศゎ⺯ග ᐃࡀྍ⬟ࠋ(2) ࢱࣥࣃࢡ㉁࣭ࣉࣟࢸ࣮࣒࢜㛵㐃ᶵჾ
3-<2>-(4) ࣐࢖ࢡࣟࣉ࣮ࣞࢺࣇ࢛ࢺ࣓࣮ࢱ࣮

2-<1>-(2) ㉁㔞ศᯒ⿦⨨

Multiskan FC

UPLC-MSࢧ࣮ࣔࣇ࢕ࢵࢩ࣮ࣕࢧ࢖࢚ࣥࢸ࢕ࣇ࢕ࢵࢡ♫᪥ᮏ࢛࣮࢘ࢱ࣮ࢬ♫96 ࢙࢘ࣝ࠾ࡼࡧ 384 ࢙࢘ࣝࣉ࣮ࣞࢺࢆ⏝࠸࡚ 340-

⪏ᅽᛶ࡟ඃࢀࠊ2 ᾮ

850 nm ࡢἼ㛗⠊ᅖ࡛྾ගᗘ

࡟ࡼࡿࢢࣛࢹ࢕࢚ࢆ ᐃྍ⬟ࠋࡍ࡭࡚ࡢ࢙࢘

ࣥࢺศᯒࡀྍ⬟ࠋࣝࢆࡦ࡜ࡘࡢගᏛ⣔࡛ ᐃ

UV ᳨ฟჾࢆഛ࠼࡚

ࡋࡲࡍࠋࢩ࢙࢖࢟ࣥࢢ᧯స

࠸ࡿࠋESI ἲ࡟ࡼࡿࡀྍ⬟ࠋ㉁㔞ศᯒࡀྍ⬟ࠋ

3-<3>-(1) ෭༷ CCD ࣓࢝ࣛ
Ez-࢟ࣕࣉࢳ࣮ࣕAE-9150
3-<4>-(3) ศගගᗘィ

ATTO ♫෭༷ CCD ࣓࢝ࣛࢆ฼⏝ࡋ࡚

BioSpectrometerⓎගࢆ᳨ฟࡍࡿࠋ࢙࢘ࢫࢱ

࢚ࢵ࣌ࣥࢻࣝࣇ♫࣭ࣥࢧࢨ࣭ࣥࣀ࣮ࢨࣥࣈࣟࢵ

200㹼830 nm ⮬⏤㑅ᢥἼࢺ࡟࠾ࡅࡿࢣ᳨࣑࣑ࣝฟ࡞࡝㛗ྍ⬟ࠋ࡟฼⏝ྍ⬟ࠋ

⮬ືẚ⋡ィ⟬࡟ࡼࡗ࡚ࢫ
࣌ࢡࢺࣝࢢࣛࣇ࡟ヨᩱࡢ⣧ᗘࢆ⾲♧࡛ࡁࡿࠋ

3-<3>-(2) ⺯ගⓎග࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒
AEQUORIA
὾ᯇ࣍ࢺࢽࢡࢫ♫3-<5>-(1) ࢖࣓࣮ࢪࣥࢢࢧ࢖ࢺ࣓࣮ࢱ࣮

㉸㧗ឤᗘ෭༷ CCD࣓࢝ࣛ࡟ࡼࡾ⤌⧊ࣞ

IN Cell Analyzer 2200

࣋ࣝࡢ⺯ග࣭ⓎගࡢGE ࣊ࣝࢫࢣ࢔ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫᳨ฟࡀྍ⬟ࠋ

࣐ࣝࢳ࢙࢘ࣝࣉ࣮ࣞࢺ࡬᧛✀ࡋࡓ⣽⬊➼ࡢ඲⮬ື᧜ᙳཬࡧ⤫ィᏛⓗゎᯒࡀ⾜࠼ࡿࠋ7 Ⰽࡢ༙ᑟయࣛ
ࣥࣉ࡟ࡼࡗ࡚ከⰍ࡛ࡢ⺯ගほᐹ࡜᧜ᙳࡀྍ⬟ࠋ඲

3-<4>-(1) ᚤ㔞ࢧࣥࣉࣝศගගᗘィ⮬ື࡛᧜ᙳࡉࢀࡓ⏬ീࢆ௜ᒓࡢࢯࣇࢺ࢙࢘࢔࡛⤫NanoVueィฎ⌮ࠋ⸆๣ࡢGE ࣊ࣝࢫࢣ࢔ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫㔞ⓗホ౯ࡸᮍ▱࢟ࣗ࣋ࢵࢺࢆ౑⏝ࡏ⸆๣ࡢࢫࢡ࣮ࣜ

ࡎࠊᑡ㔞ヨᩱࡢ ᐃࡀࢽࣥࢢ࡞࡝࡟ࡶ

ྍ⬟ࠋCyDye ᶆ㆑ࠊ᰾౑⏝ྍ⬟ࠋ㓟⃰ᗘ࣭⣧ᗘࠊࢱࣥࣃ
ࢡ㉁⃰ᗘ࡞࡝ࡢ ᐃ࡟
3-<6>-(1) ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮

౑⏝ࠋࢭࣝ࢔ࢼࣛ࢖ࢨ࣮EC800ࢯࢽ࣮♫3-<4>-(2) ศගගᗘィ⺯ගᢠయ࡛ᶆ㆑ࡋࡓ⣽⬊ࢆ㧗㏿࡟ゎᯒࠋ࣮࢜ࢺࢧ

Ultrospec2100 pro

ࣥࣉ࣮ࣛ࡟ࡼࡿ 48 ࢧࣥࣉࣝ㐃⥆⮬ື ᐃࡀྍ⬟ࠋGE ࣊ࣝࢫࢣ࢔ࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫4 ᮏࡢ࣮ࣞࢨ࣮

⣸እ࠿ࡽྍど㡿ᇦ࡟࠾

㸦405, 488, 561, 642

ࡅࡿヨᩱࡢ྾ගᗘࡀ

nm㸧࡜ 6 ಶࡢ⺯ගᐃ࡛ࡁࡿ⿦⨨ࠋȝOࡢᚤ᳨ฟჾࢆᦚ㍕ࠋ㔞ヨᩱ࡟ᑐᛂࠋ᰾㓟ࡸ
ࢱࣥࣃࢡ㉁ࡢ⃰ᗘ ᐃ࡞࡝࡟฼⏝ࠋ



4-<3>-(1) ṇ❧ᆺ㢧ᚤ㙾

3-<6>-(2) ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮
ࢭࣝࢯ࣮ࢱ࣮SH800

Axioskopࢯࢽ࣮♫࣮࢝ࣝࢶ࢓࢖ࢫ♫⺯ගᢠయ࡛ᶆ㆑ࡋࡓ⣽⬊ࢆศྲྀ㸦ࢯ࣮ࢸ࢕ࣥࢢ㸧ᑐ≀ࣞࣥࢬࡣ 5 ಸࠊ10 ಸࠊ20ࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ2 ᪉ྥྠ᫬ࢯ࣮ࢸ࢕ࣥࢢ࠾ࡼࡧ

ಸࠊ40 ಸࡢ 4 ࡘࡀࡘ࠸࡚࠾

96 ࢙࢘ࣝࣉ࣮ࣞࢺࡲ࡛ࡢ࣐ࣝࢳ࢙࢘ࣝࣉ࣮ࣞࢺ࡬ࡾࠊ ࣮࢝ࣛࡢ෗┿᧜ᙳࡶྍࡢࢯ࣮ࢸ࢕ࣥࢢࡀྍ

⬟ࠋࣉࣞࣃ࣮ࣛࢺࡢほᐹࡀྍ⬟ࠋ4 ᮏࡢ࣮ࣞࢨ࣮

⬟ࠋ

㸦405, 488, 561, 638
nm㸧࡜ 6 ಶࡢ⺯ග᳨ฟჾࢆᦚ㍕ࠋ

4-<4>-(1) ᐇయ㢧ᚤ㙾
Stemi 2000 +࣮࢝ࣝࢶ࢓࢖ࢫ♫1.9 ࠿ࡽ 225 ಸࡢಸ⋡࡛ࣂ࢖࢜(4) 㢧ᚤ㙾ࡸᮦᩱヨᩱ⏬ീࢆ࡜ࡽ࠼ࡿࡇ
4-<1>-(2) ඹ↔Ⅼ࣮ࣞࢨ࣮ࢫ࢟ࣕࣥ㢧ᚤ㙾࡜ࡀྍ⬟ࠋ

LSM710

7:1 ࢬ࣮࣒ᶵ⬟࡛ࠊ㐃⥆ྍኚಸ࣮࢝ࣝࢶ࢓࢖ࢫ♫⋡࠿ࡽಶูࡢಸ⋡ࢫࢸࢵࣉࡲ

458, 488, 514, 543, 633 nm ࡢ࣮ࣞࢨ࣮ࢆᦚ㍕ࠋࢱ࢖࡛ኚ᭦ྍ⬟ࠋ

࣒ࢩ࣮ࣜࢬࠊ
FRAPࠊFRET ࡢ௚࡟ࠊࢫ࣌ࢡࢺࣝ࢖
࣓࣮ࢪࣥࢢ㸦㏆᥋

4-<4>-(2) ᐇయ⺯ග㢧ᚤ㙾ࡋࡓ⺯ගࡢศ㞳ࠊ

LEICA MA10Fࢫ࣌ࢡࢺ࣮ࣝ࢝ࣈࣛ࢖࢝♫ࡢ ᐃ㸧ࡶྍ⬟ࠋ×8 ಸ㹼×80 ಸࡲ࡛ࡢ↓ẁ㝵ᣑ኱ほᐹ࡜෗┿᧜ᙳࡀྍ⬟ࠋ⺯ගࡣ⥳Ⰽ⺯ග㸦GFP,

4-<2>-(1) ಽ❧ᆺ⺯ග㢧ᚤ㙾

YFP㸧࡜㉥Ⰽ⺯ග㸦RFP,

Axiovert

DsRed ➼㸧ࢆぢࡿࡇ࡜ࡀ࣮࢝ࣝࢶ࢓࢖ࢫ♫ྍ⬟ࠋ᭱㧗 5 ✀㢮ࡢࣇ࢕ࣝࢱ࣮ࡀ
⿦╔࡛ࡁࡿࠋど㔝ᚄࡀ 23 mm

5-<3>-(1) ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒

(5) ࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ㛵㐃ᶵჾ

MASCOT
Matrix Science ♫5-<1>-(1) 㟁ẼὋືࢤࣝ⏬ീゎᯒ⿦⨨

ࢱࣥࣃࢡ㉁ࡢ㑇ఏᏊྠᐃࢆᨭ᥼ࡍࡿࢩࢫࢸ࣒ࠋࢹ

Image Master Platinum࣮ࢱ࣮࣋ࢫࢆࡶ࡜࡟௬᝿ୖࡢ࣌ࣉࢳࢻ᩿∦ࡢ ࢭ࢔࣐ࢩ࣒ࣕࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫ࢵࢺࢆⓎ⏕ࠊMALDI-TOF ࡟ࡼࡿ࣌ࣉࢳࢻ MS ࣇ࢕஧ḟඖ㟁ẼὋື࡛ศ㞳ࡉࢀࡓࢱࣥࣃࢡ㉁ࢫ࣏ࢵࢺ

࣮ࣥ࢞ࣉࣜࣥࢸ࢕ࣥࢢ

ࣃࢱ࣮ࣥࠊ➼㟁ⅬࠊศᏊ㔞ࠊ࣮࣒࣎ࣜࣗ➼ࢆゎᯒࠋ
ImageMaster 2D Eliteࠊ2D Database ࡣ 2 ✀㢮௨ୖࡢࢤࡸ TOF/TOF ゎᯒ࡛ᚓࡽࢀࡿヨᩱࡢࢹ࣮ࢱ࡜

ࣝࡢẚ㍑ゎᯒ࠿ࡽࢫ࣏ࢵࢺࡢ᭷↓ࠊቑῶࡢᩘ್໬ࡸ

↷ྜࡍࡿࡇ࡜࡟ࡼࡾ㑇ࢹ࣮ࢱ࣮࣋ࢫ໬ࢆࢧ࣏࣮ࢺࠋࢤࣝࠊࣈࣟࢵࢸ࢕ࣥࢢ

ఏᏊࢆྠᐃࠋ

࣓ࣥࣈࣞࣥࡢ⏬ീࡣࢹࢫࢡࢺࢵࣉࢫ࢟ࣕࢼ࣮
Image Scanner ࡲࡓࡣࣂ5-<3>-(2) ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒

ࣜ࢔ࣈࣝ࢖࣓࣮ࢪ࢔ࢼ

ProteinLynx Global SERVER 㸦PLGS㸧ࣛ࢖ࢨ࣮Typhoon ࡞࡝

Waters ♫ࡢ⏬ീゎᯒ⿦⨨࠿ࡽࡣ

Waters Xevo Qtof ࡢ⢭ᐦ㉁㔞ࢹ࣮ࢱࢆᇶ࡜ࡋ࡚ࠊ⊂TIFF ᙧᘧࡢྲྀࡾ㎸ࡳࡀ⮬ࡢࣇ࢕ࣝࢱࣜࣥࢢᶵ⬟ࡸィ⟬ᶵ⬟ࢆ⏝࠸࡚ゎᯒྍ⬟ࠋࢆ⾜࠺ࠊᐃ㔞ⓗ࠾ࡼࡧ୺せᶵ⬟ᐃᛶⓗࣉࣟࢸ࣑࢜ࢡࢫ࣭ ࢫ࣏ࢵࢺ᳨▱ࠊࣂࢵࢡࢢࣛ࢘ࣥࢻ๐㝖◊✲ࡢ MS ࢖ࣥࣇ࢛࣐

࣭ 100 ᯛࡲ࡛ࡢ⮬ືࢫ࣏ࢵࢺ࣐ࢵࢳࣥࢢ

ࢸ࢕ࢡࢫࣉࣛࢵࢺࣇ࢛࣭ ࣐࣮࣮࢝/࣐࣮࣮࢝ࢫ࣏ࢵࢺ࠿ࡽࡢศᏊ㔞࣭➼㟁

࣮࣒ࠋ

ⅬỴᐃ
࣭ ࣐ࢵࢳࣥࢢࢫ࣏ࢵࢺࡢ㔞ኚ໬ࡢ⾲♧5-<4>-(1) ศᏊ㛫ࢿࢵࢺ࣮࣡ࢡ/ࣃࢫ࢙࢘࢖ゎᯒ࣭ ࢖ࣥࢱ࣮ࢿࢵࢺࢹ࣮ࢱ࣮࣋ࢫࡢ᳨⣴ࢹ࣮ࢱ࣮࣋ࢫ

࣭ 2D DIGE ࡟ᑐᛂ

IPAࢺ࣑࣮ࢹࢪࢱࣝࣂ࢖࢜ࣟࢪ࣮♫5-<2>-(1) ⺮ⓑ㉁❧యᵓ㐀᝟ሗゎᯒ⿦⨨࣐࢖ࢡࣟ࢔ࣞ࢖ࡸ࣓ࢱ࣑࣎ࣟࢡࢫࠊࣉࣟࢸ࣑࢜ࢡ

DSModelingࢫࠊRNA-Seq ࡞࡝ࡢᐇ㦂ࡼࡾᚓࡽࢀࡓࢹ࣮ࢱࢆࡶ

Accelrys ♫࡜࡟ࡋ࡚⏕≀Ꮫⓗ࡞ᶵ⬟ࡢゎ㔘ࡸࣃࢫ࢙࢘࢖ゎᯒ

⺮ⓑ㉁࣭᰾㓟ࡢ❧యᵓ㐀ࢆ 3 ḟඖⓗ࡟ྍど໬ࡍࡿࢆ⾜࠺ࡇ࡜ࡀ࡛ࡁࡿࢯࣇࢺ࢙࢘࢔ࠋ㇏ᐩ࡞┦஫స⿦⨨ࠋ࣍ࣔࣟࢪ࣮ࣔࢹࣜࣥࢢἲ࡜࣮ࣔࣞ࢟ࣗࣛࢲ

⏝᝟ሗࡸศᏊ᝟ሗࡀࢹ࣮ࢱ࣮࣋ࢫ໬ࡉࢀ࡚࠸ࡿࡓ

࢖ࢼ࣑ࢵࢡࢫἲ࡟

ࡵࠊศᏊ⏕≀Ꮫࡢ㎡᭩࡜ࡋ࡚ࡶ౑⏝ྍ⬟ࠋࡼࡾ㧗ศᏊࡢ❧యᵓ㐀ࢆண ࡍࡿࢩࢫࢸ࣒ࠋ

5-<5>-(1) ࣐࢖ࢡࣟ࢔ࣞ࢖⏝ࢹ࣮ࢱゎᯒ(7) 㐲ᚰศ㞳ᶵࢯࣇࢺ࢙࢘࢔
GeneSpring

7-<1>-(1) ㉸㐲ᚰศ㞳ᶵࢺ࣑࣮ࢹࢪࢱࣝࣂ࢖࢜ࣟࢪ࣮♫Optima L-70K

㑇ఏᏊⓎ⌧࢔ࣞ࢖࡞࡝ࡢᩘ್ゎᯒࠊ⏕≀Ꮫⓗゎᯒ࣋ࢵࢡ࣐ࣥࢥ࣮ࣝࢱ࣮♫࡞࡝ࠊࡉࡲࡊࡲ࡞ᶵ⬟ࢆᦚ㍕ࡋࡓࢹ࣮ࢱ࣐࢖ࢽࣥ

᭱㧗 70 kUSP ࠋ10 PO × 6 ᮏࢢࢯࣇࢺ࢙࢘࢔ࠋ㑇ఏᏊⓎ⌧ゎᯒᶵ⬟࡟ຍ࠼ࠊࡢ㉸㐲ᚰศ㞳ࡀྍ⬟ࠋ

miRNAࠊReal Time PCRࠊCNVࠊSNPࠊPathway ゎᯒ➼ࡶ⾜࠺஦ࡀྍ⬟ࠋ

7-<3>-(1) ෾⤖஝⇱ᶵ
FDU-810EYELA ♫
ᑡ㔞࠿ࡽẚ㍑ⓗከ㔞࡞ࡓࢇࡥࡃ㉁ࠊ㓝⣲➼ࡢ(6) ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮࣭㟁ẼὋືᶵჾᕼ㔘Ỉ⁐ᾮࡢ⃰⦰ཬࡧ஝⇱ࠊ⏕యヨᩱࡢ⃰⦰ཬࡧ஝⇱ ࠋ

6-<2>-(1) ➼㟁Ⅼ㟁ẼὋືࢩࢫࢸ࣒
IPGphor + SE600 Ruby+Ettan Dalt6࢔࣐ࢩ࣒ࣕࣂ࢖࢜ࢧ࢖࢚ࣥࢫ♫➼㟁Ⅼ㟁ẼὋື࡜ SDS ࣏ࣜ࢔ࢡࣜࣝ࢔࣑ࢻࢤࣝ㟁(8) ᇵ㣴ᶵ࣭⣽⬊◚○ᶵẼὋື࡟ࡼࡾࠊᩘ༓ಶࡢࢱࣥࣃࢡ㉁ࢆ 2 ḟඖ࡛ᒎ㛤ࠋ

8-<4>-(1) ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵBiorupterࢥࢫࣔࣂ࢖࢜♫ᐦ㛢ᘧ࡛」ᩘヨᩱࡢྠ᫬㉸㡢Ἴฎ⌮ࡀྍ⬟ࠋ
10 ml ⏝ࢫࣆࢵࢶ࡞ࡽ᭱
኱ 24 ᮏࠊ1.5 ml ࣐࢖ࢡࣟࢳ࣮ࣗࣈ࡞ࡽ 24 ᮏࠊ50
ml ࢳ࣮ࣗࣈ࡞ࡽ 12 ᮏࠋ࣐ࣝࢳࢱ࢖࣐࣮࡟ࡼࡾ◚○᫬㛫ࡢࢭࢵࢺࡀྍ⬟ࠋ

8-<4>-(2) ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵ

8-<5>-(1) ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵࣅ࣮ࢬᘧ࣍ࣔࢪࢼ࢖ࢨ࣮

࣏ࣜࢺࣟࣥ࣍ࣔࢤࢼ࢖ࢨ࣮ PT-2100

࣐ࣝࢳࣅ࣮ࢬࢩࣙࢵ࣮࢝MB455GU(S)Kinematica ♫Ᏻ஭ჾᲔᰴᘧ఍♫ࢻࣛ࢖ࣈࢩࣕࣇࢺࡢඛ➃࡟࠶ヨᩱࢆ࢞ࣛࢫࣅ࣮ࢬࡸ࣓ࢱࣝࢥ࣮ࣥ࡜ඹ࡟᧠ᢾࡍࡿᅇ㌿ลࢆ㧗㏿࡛ᅇ㌿ࡉࡏࡿࡿࡇ࡜࡛◚○ࠋヨᩱ㛫ࡢࢡࡇ࡜࡛⏕ࡌࡿỈὶ࡜ࠊ࢟ࣕࣅ

ࣟࢫࢥࣥࢱ࣑ࢿ࣮ࢩࣙࣥࡸ

ࢸ࣮ࢩࣙࣥ࡟ࡼࡿ㉸㡢Ἴ࡛ヨRase ࡢΰධࢆ㜵Ṇࠋ㓝ᩱࢆ◚○ࠋື≀ࡸ᳜≀ࡢ⤌⧊ẕࠊࣂࢡࢸࣜ࢔ࠊ࢝ࣅࠊ

࠿ࡽࡢ RNA ᢳฟ➼࡟౑⏝ࠋᅛ ࠸ື≀⤌⧊ࠊ᳜≀⤌⧊ࢆᩘ ༑⛊ࠥᩘศ࡛◚○ࠋู⣬ ࢤࣀ࣒◊✲ศ㔝฼⏝ᩱ㔠⾲                      ௧࿴ 4.5.1 ⌧ᅾ஦     㡯ᩱ㔠ഛ⪃

1. Ⓩ㘓ᩱ
Ⓩ㘓ᩱ

1,000 ෇/ࢢ࣮ࣝࣉ࣭ᖺ

ͤᖺᗘẖࡢ᭦᪂
㸦4/1 㹼3/31㸧

200 ෇/ࢧࣥࣉࣝ
1~71 ࢧࣥࣉ
ࣝ
700 ෇/ࢧࣥࣉͤ96 ࢧࣥࣉࣝ௨ୖ   150 ෇/ࢧࣥࣉࣝࣝ
1~21 ࢧࣥࣉࣝ  ༢౯ኚື

2. ཷクᩱ㔠⾲ ͤ nn! n ࡣ⟶⌮␒ྕ
DNA ཷクゎᯒ! 

DNA ࢩ࣮ࢣࣥࢧ࣮㸦཯ᛂ῭㸧! 

DNA ࢩ࣮ࢣࣥࢧ࣮㸦཯ᛂ๓㸧ͤ22㹼29 ࢧࣥࣉࣝ
ͤ30㹼66 ࢧࣥࣉࣝ  500 ෇/ࢧࣥࣉࣝ
ͤ67㹼94 ࢧࣥࣉࣝ  ༢౯ኚື
ͤ95 ࢧࣥࣉࣝ௨ୖ
  350 ෇/ࢧࣥࣉࣝͤ኱㔞ࢧࣥࣉࣝᛂ┦ㄯ! 

DNA ࢩ࣮ࢣࣥࢧ࣮
㸦ࣇࣛࢢ࣓ࣥࢺゎᯒ㸧

200 ෇/ࢧࣥࣉࢩ࣮ࢣࣥࢫ࢜ࣉࢩࣙࣥࢧ࣮ࣅࢫ
㸦PCR ቑᖜ࣭PCR ⏘≀⢭〇࡞࡝㸧ಶู┦ㄯࣝ
1~71 ࢧࣥࣉࣝ!

ࣜ࢔ࣝࢱ࢖࣒ PCR ࢜ࣉࢩࣙࣥࢧ࣮ࣅࢫ  (ࣉࣛ࢖࣐࣮タィ࣭ቑᖜ☜ㄆ࡞࡝)ͤ96 ࢧࣥࣉࣝ௨ୖ
  150 ෇/ࢧࣥࣉࣝಶู┦ㄯRNA ཷクゎᯒ! 

Promega Maxwell㸦RNA ᢳฟ⢭〇ཷク㸧

! ࣂ࢖࢜࢔ࢼࣛ࢖ࢨ Agilent 2100
㸦RNA ཷクศᯒ㸧⣽⬊ 850 ෇/
1 ࢧࣥࣉࣝ
⤌⧊ 1200 ෇/
1 ࢧࣥࣉࣝͤ ⃰ᗘ⣧ᗘ ᐃྵࡴͤ BioAnalyzer ࡟ࡼࡿရ㉁ࢳ࢙ࢵࢡࡣูᩱ㔠5,000 ෇/ศᯒ
1~12 ࢧࣥࣉࣝͤ ヨ⸆࣭ࢳࢵࣉ௦ྵࡴͤ ࢳࢵࣉࡢࡳ 3,000 ෇

30,000/1 ࢧࣥࣉࣝ
ࢫࣛ࢖ࢻࡣᐇ㈝࢔ࣞ࢖ࢫࣛ࢖ࢻ௦㔠ࡢ┠

10,000 ෇/
1 ࢧࣥࣉࣝͤ ┦ྠᛶ᳨⣴ྵࡴ࣐࢖ࢡࣟ࢔ࣞ࢖ཷクゎᯒ! ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼᏳ        
࣭8 ࢔ࣞ࢖̿⣙ 25 ୓෇
࣭4 ࢔ࣞ࢖̿⣙ 13 ୓෇

16SrRNA 㓄ิゎᯒ
16SrRNA 㓄ิゎᯒ㸦⣽⳦ࡢྠᐃ㸧
ࢱࣥࣃࢡ㉁࣭ࣉࣟࢸ࣮࣒࢜㛵㐃ᶵჾ

2-<1>-(2)㉁㔞ศᯒ⿦⨨ UPLC-MSಶู┦ㄯ㉳ື࣭⤊஢ 3,000 ෇/1ᅇ࣮ࣝࢳࣥ ᐃ 1,000 ෇/1 ⎼᮲௳᳨ウ 8,000 ෇/1 ᑐ㇟≀ᵓ㐀ゎᯒ 5,000 ෇/1 ᑐ㇟≀◊✲ᇶ┙㛤Ⓨ᥎㐍⤫ᣓᐊ࡟ࡼࡿཷクゎᯒࢤࣀ࣒⦅㞟⣽⬊సᡂ㸦CRISPR/Cas9

gRNA タィ࣭

࢜ࣉࢩࣙࣥ

౑⏝㸧

ㄪᩚࠊ⣽⬊࡟

96 ࢙࢘ࣝࣉ࣮ࣞࢺ࡬ࡢ

࠾ࡅࡿኚ␗ᑟ

⣽⬊ࡢ༢㞳:3,000 ෇/1

ධຠ⋡☜ㄆ

ࣉ࣮ࣞࢺ

50,000 ෇ኚ␗ᑟධ⣽⬊ࡢࢩ࣮ࢡ/1 ࢧࣥࣉࣝ

࢚ࣥࢫ:10,000 ෇/8 ࢡ࣮ࣟࣥ」ᩘࡢ࢞࢖ࢻ RNA ࡢ౑⏝:10,000 ෇/1 ࢧࣥࣉࣝࢤࣀ࣒⦅㞟࣐࢘ࢫసᡂ㸦CRISPR/Cas9

gRNA タィ࣭gRNA ㄪᩚᚋࡢཷ⢭༸౑⏝㸧ㄪᩚࠊ⣽⬊࡟

࡬ࡢ࢚ࣞࢡࢺ࣏࣮ࣟࣞ

࠾ࡅࡿࡢࢤࣀ

ࢩ࣭ࣙࣥ⬇⛣᳜ࡲ࡛ࡢ࣒⦅㞟ຠᯝࡢ

ሙྜࡣ 100,000 ෇☜ㄆࠊཷ⢭༸

/1 ࢧࣥࣉࣝ

࡬ࡢ࢚ࣞࢡࢺ
࣏࣮ࣟࣞࢩࣙ
࣭ࣥ⬇⛣᳜ࡲ
࡛
150,000 ෇/1 ࢧࣥࣉࣝ
㉮ᰝᆺ㟁Ꮚ㢧ᚤ㙾ほᐹ

1 ࢧࣥࣉࣝࡢ

2㹼4 ࢧࣥࣉࣝࡢሙྜࡢ

ࡳࡢሙྜ

1 ࢧࣥࣉࣝ࠶ࡓࡾ༢౯

ᚋᅛᐃ(1,000

ᚋᅛᐃ(500 ෇)ࠊ⬺Ỉ෇)ࠊ⬺Ỉ࣭ࣇ࣮ࣜࢬࢻࣛ࢖

࣭ࣇ࣮ࣜࢬࢻ

(1,000 ෇)ࠊ࢜ࢫ࣑࣒࢘

ࣛ࢖(2,000ࢥ࣮ࢸ࢕ࣥࢢ(1,000෇)ࠊ࢜ࢫ࣑෇)ࠊほᐹ࣭᧜ᙳ(1,000࣒࢘ࢥ࣮ࢸ࢕

෇)ࣥࢢ(2,000෇)ࠊほᐹ࣭
᧜ᙳ(1,000෇)ィ 6,000 ෇(࢜ࣉࢩࣙࣥ:⣽⬊ᇵ㣴
2,000 ෇/4 ࢧࣥࣉࣝࡲ࡛)
3. ඹྠ฼⏝ᶵჾᩱ㔠⾲ ͤn-<n>-(n)ࡣ⟶⌮␒ྕ
DNA 㛵㐃ᶵჾ! 

DNA ࢩ࣮ࢣࣥࢧ࣮3500

ཷクᩱ㔠⾲ཧͤ ┦クࡢࡳ↷! 

DNA ከᆺゎᯒࢯࣇࢺ ࢪ࣮࣐ࣥࢵࣃ࣮---! 

DNA 㓄ิゎᯒࢯࣇࢺ SEQUENCHER---

!  ࣜ࢔ࣝࢱ࢖࣒ᐃ㔞 PCR
ABI Step one plus! ࣂ࢖࢜࢔ࢼࣛ࢖ࢨ
Agilent 2100

500 ෇/౑⏝---ͤ 1 ౑⏝=3 ᫬㛫㎾㸦3 ᫬㛫௨ୖ౑⏝ =2 ౑⏝㹼㸧ͤ ࢳࢵࣉ 3,000 ෇/1 ᯛͤ ཷクศᯒࡣཷクᩱ㔠⾲ཧ↷! ࣁ࢖ࣈࣜࢲ࢖ࢮ࣮ࢩ࣮ࣙࣥ࢜ࣈࣥ
  Agilent G2545A

1,000 ෇/౑⏝! ࣐࢖ࢡࣟ࢔ࣞ࢖ࢫ࢟ࣕࢼ
  Agilent ArrayScan

1,000 ෇/ࢫ࢟ࣕࣥ! ࢚ࣞࢡࢺ࣏࣮ࣟࣞࢱ࣮
Gene Pulser II㈚ฟࡢሙྜ
100 ෇/㐌! 㑇ఏᏊᑟධ⿦⨨Neon Transfection system㈚ฟࡢሙྜ
100 ෇/᪥ͤ฼⏝ࡣせ┦ㄯ    
ͤ10 Pl ࢟ࢵࢺ 2,000 ෇/
1 ౑⏝

! ࣐ࣝࢳࣅ࣮ࢬࣂ࢖࢜࢔ࢵࢭ࢖⿦⨨Luminex

500 ෇/౑⏝ͤ฼⏝ࡣせ┦ㄯ! ࣃࣝࢫࣇ࢕࣮ࣝࢻࢤࣝ㟁ẼὋື⿦⨨
CHEF-DRII

500 ෇/Ὃືͤ฼⏝ࡣせ┦ㄯ! 

UV ࢡࣟࢫ࣮ࣜࣥ࢝ GS Gene Linker---

ͤ฼⏝ࡣせ┦ㄯ

ࢱࣥࣃࢡ㉁࣭ࣉࣟࢸ࣮࣒࢜㛵㐃ᶵჾ! ㉁㔞ศᯒ⿦⨨ UPLC-MS

1,000 ෇/౑⏝ගᏛ⣔ศᯒᶵჾ
! ࣐ࣝࢳ⺯ගࢫ࢟ࣕࢼ Typhoon 9400

500 ෇/౑⏝! ࣐ࣝࢳࣛ࣋ࣝࣉ࣮ࣞࢺ࣮ࣜࢲ࣮
  Wallac1420 ARVO SX

300 ෇/᫬㛫! ࣐ࣝࢳࣛ࣋ࣝࣉ࣮ࣞࢺ࣮ࣜࢲ࣮
  Wallac1420 ARVO SX-DELFIA300 ෇/᫬㛫! ࣐ࣝࢳ࣮ࣔࢻࣉ࣮ࣞࢺ࣮ࣜࢲ࣮

300 ෇/᫬㛫  Nivo Alpha S! ࣐࢖ࢡࣟࣉ࣮ࣞࢺࣇ࢛ࢺ࣓࣮ࢱ࣮

---  Multiskan FC! ෭༷ CCD ࣓࢝ࣛ Ez-࢟ࣕࣉࢳ࣮ࣕ
AE-9150

250 ෇/᫬㛫! ⺯ගⓎග࢖࣓࣮ࢪࣥࢢࢩࢫࢸ࣒
AEQUORIA

500 ෇/౑⏝! ᚤ㔞ࢧࣥࣉࣝศගගᗘィ NanoVue---

! ศගගᗘィ Ultrospec2100 pro---

! ࢖࣓࣮ࢪࣥࢢࢧ࢖ࢺ࣓࣮ࢱ࣮
  IN Cell Analyzer㸦᧜ᙳ㸧

500 ෇/౑⏝! ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮ ࢭࣝ࢔ࢼࣛ࢖

500 ෇/౑⏝ͤ฼⏝ࡣせ┦ㄯͤゎᯒࢯࣇࢺࡢࡳࡢ
฼⏝ࡣ↓ᩱ

ࢨ࣮
EC800
! ࣇ࣮ࣟࢧ࢖ࢺ࣓࣮ࢱ࣮ ࢭࣝࢯ࣮ࢱ࣮
SH800

500 ෇/౑⏝ඹ↔Ⅼ࣮ࣞࢨ࣮ࢫ࢟ࣕࣥ㢧ᚤ㙾 LSM

1,000 ෇/౑⏝ͤࢳࢵࣉ 3,000 ෇/1 ᯛ㢧ᚤ㙾! 710
! ಽ❧ᆺ⺯ග㢧ᚤ㙾 Axiovert

250 ෇/౑⏝! ᐇయ⺯ග㢧ᚤ㙾 LEICA MZ 10F

250 ෇/౑⏝! ṇ❧㢧ᚤ㙾 Axioskop---! ᐇయ㢧ᚤ㙾 Stemi 2000---ͤ⺯ග౑⏝᫬ࡢࡳ

ࣂ࢖࢜࢖ࣥࣇ࢛࣐ࢸ࢕ࢡࢫ㛵㐃ᶵჾ! ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒
MASCOT---! ࣉࣟࢸ࣑࢜ࢡࢫᨭ᥼ࢩࢫࢸ࣒
  ProteinLynx Global SERVER---! ศᏊ㛫ࢿࢵࢺ࣮࣡ࢡ/ࣃࢫ࢙࢘࢖ゎᯒࢹ࣮ࢱ࣮࣋ࢫ---! 

IPA࣐࢖ࢡࣟ࢔ࣞ࢖⏝ࢹ࣮ࢱゎᯒࢯࣇࢺ࢙࢘࢔
  GeneSpringͤ฼⏝ࡣせ┦ㄯ---ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮࣭㟁ẼὋື㛵㐃ᶵჾ! ➼㟁Ⅼ㟁ẼὋືࢩࢫࢸ࣒
  IPGphor+SE600 Ruby+Ettan Dalt6

1,000 ෇/౑⏝㐲ᚰศ㞳ᶵ! ㉸㐲ᚰศ㞳ᶵ Optima L-70K

! ෾⤖஝⇱ᶵ FDU-810--500 ෇/24 ᫬㛫ᇵ㣴ᶵ࣭⣽⬊◚○ᶵ! ᐦ㛢ᆺ㉸㡢Ἴ◚○ᶵ Biorupter---! ࣅ࣮ࢬᘧ࣍ࣔࢪࢼ࢖ࢨ࣮  ࣐ࣝࢳࣅ࣮ࢬࢩࣙࢵ࣮࢝
MB455GU(S)100 ෇/౑⏝! ࣏ࣜࢺࣟࣥ࣍ࣔࢤࢼ࢖ࢨ࣮ PT-2100---

3.ᐇ㦂ᐊ࣭ᐇ㦂ྎᐇ㦂ྎ㸦1 ࢫ࣮࣌ࢫศ:୰ኸᐇ㦂ྎ༙ศ㸧

10,000 ෇/᭶ͤ฼⏝ࡣせ┦ㄯ᳜≀⏝ࢢ࣮ࣟࢫ࢟ࣕࣅࢿࢵࢺ
ࢥ࢖ࢺࢺࣟࣥ㸦401㸧
᳜≀᱂ᇵᐊ



P1

ᐊ

50,000 ෇/᭶◊ಟࢭ࣑ࢼ࣮ᐊ

400 ෇/᫬㛫ͤᏛእࡢࡳㄢ㔠100 ෇㹼500 ෇㸨ᅵ᪥⚃᪥௚
ᙜศ㔝ࡀᐃࡵࡿఇ㤋᪥

5,000 ෇/᭶10,000 ෇/᭶

4. ᫬㛫እ฼⏝ᩱ㔠᫬㛫እ฼⏝ᩱ㔠

/౑⏝





฼⏝ࡢᡭᘬࡁ฼⏝⪅㈨᱁࣭Ⓩ㘓ձ ฼⏝⪅㈨᱁
ᒱ㜧኱Ꮫ⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝㸦௨ୗࠕࢤࣀ࣒◊✲ศ㔝ࠖ࡜࠸࠺ࠋ㸧ࢆ฼⏝࡛ࡁࡿ⪅ࡣࠊᒱ㜧኱Ꮫཬࡧᒱ㜧⸆⛉኱Ꮫࡢ⫋ဨࠊ኱Ꮫ㝔⏕ࠊᏛ⏕ཬࡧࢤࣀ࣒◊✲ศ㔝㛗㸦௨ୗࠕศ㔝㛗ࠖ࡜࠸࠺ࠋ㸧ࡀ㐺ᙜ࡜ㄆࡵࡓ⪅࡜ࡍࡿࠋղ ฼⏝⪅࣭฼⏝㈐௵⪅࣭⤒㈝㈇ᢸ㈐௵⪅฼⏝࡟㝿ࡋ࡚ࡣࠊ฼⏝㈐௵⪅ ฼⏝࡟ࡘ࠸࡚ࡢ㈐௵ࢆᣢࡘ⪅࡛ࠊᩍဨ࡟㝈ࡿ ࡼࡾࠊ⤒㈝㈇ᢸ㈐௵⪅฼⏝࡟ಀࡿ⤒㈝࡟ࡘ࠸࡚㈐௵ࢆᣢࡘ⪅࡛ࠊᩍဨ࡟㝈ࡿ ࡜฼⏝⪅ࢆ᫂グࡋࡓ฼⏝Ⓩ㘓⏦ㄳ᭩ࢆศ㔝㛗࡟ᥦฟࡋ࡚ᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋⓏ㘓ᮇ㛫ࡣ฼⏝㛤ጞ᪥࠿ࡽ฼⏝㛤ጞ᪥ࡢᒓࡍࡿᖺᗘᮎࡲ
࡛ࢆ㝈ᗘ࡜ࡍࡿࠋࡲࡓࠊඹྠ฼⏝ᶵჾࡢ฼⏝⪅࡟ࡘ࠸࡚ࡣࠊᢎㄆࢆᚓࡓ⪅ࡢ࠺ࡕヱᙜᶵჾࡢㅮ⩦఍ࡸࢺ࣮ࣞࢽࣥࢢࢥ࣮ࢫ࡟ཧຍࡋࡓ⪅ࠊ᧯స࡟⩦⇍ࡋࡓ⪅ཬࡧ᧯స࡟⩦⇍ࡋࡓ⪅ࡢୗ࡛฼⏝ࡍࡿࡶࡢ࡜
ࡍࡿࠋճ ฼⏝Ⓩ㘓⏦ㄳ᪉ἲ
฼⏝Ⓩ㘓⏦ㄳࡢ᪉ἲ࡟ࡘ࠸࡚ࡣࠊࢤࣀ࣒◊✲ศ㔝ࡢ࣮࣒࣮࣍࣌ࢪෆ ࠕ฼⏝Ⓩ㘓⏦ㄳࠖࡢ㡯ࢆཧ↷ࡋ࡚฼⏝㈐௵⪅ࡀ⏦ㄳࡍࡿࠋմ Ⓩ㘓ෆᐜࡢኚ᭦࣭฼⏝୰Ṇ
Ⓩ㘓⏦ㄳ᭩ࡢグ㍕஦㡯࡟ኚ᭦ࡀ⏕ࡌࡓ㝿ࠊཪࡣࢤࣀ࣒◊✲ศ㔝ࡢ฼⏝ࢆ୰Ṇࡋࡓ㝿ࠊ฼⏝㈐௵⪅ࡣ㏿ࡸ࠿࡟ࠊࡑࡢ᪨ࢆศ㔝㛗࡟ᒆࡅฟࡿ࡜ඹ࡟ࠊኚ᭦ࡢሙྜࡣᢎㄆࢆᚓ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋյ ฼⏝ᢎㄆࡢྲྀᾘࡋ
฼⏝⪅ࡀἲ௧ཬࡧᒱ㜧኱Ꮫつ๎ࢆ㑂Ᏺࡋ࡞࠸ሙྜࡸࢤࣀ࣒◊✲ศ㔝ࡢ㐠Ⴀ࡟ᨭ㞀ࢆ⏕ࡌࡉࡏࡿሙྜࠊ
ศ㔝㛗ࡣ฼⏝ᢎㄆࢆྲྀᾘࡍࡇ࡜ࠊཪࡣ୍ᐃᮇ㛫ࡑࡢ⪅ࡢ฼⏝ࢆ೵Ṇࡉࡏࡿࡇ࡜ࡀ࡛ࡁࡿࠋ฼⏝ᩱ฼⏝࡟ಀࡿᩱ㔠ࡣࠊู㡯ࡢᩱ㔠⾲࡟ᚑࡗ࡚⤒㈝㈇ᢸ㈐௵⪅ࡀ㈇࠺ࡶࡢ࡜ࡋࠊ㐠Ⴀ㈝஺௜㔠ࠊᐤ௜㔠ࠊཷク◊✲㈝ࠊ⛉Ꮫ◊✲㈝⿵ຓ㔠ࡢ᣺᭰࡟ࡼࡾ⾜࠺ࠋᴗ⦼ࡢᥦฟ࡟ࡘ࠸࡚฼⏝㈐௵⪅ࡣࠊḟᖺᗘ࡟฼⏝ࢆ⥅⥆ࡍࡿሙྜࡣ๓ᖺศ 㹼 ᭶ ࠊḟᖺᗘ࡟฼⏝ࢆ⥅⥆ࡋ࡞࠸ሙྜࡣ
ᙜヱᖺᗘࡢᴗ⦼ ㄽᩥ࣭ⴭ᭩ ࢆࠊ฼⏝Ⓩ㘓⏦ㄳ᭩࡟ᚑࡗ࡚ࢤࣀ࣒◊✲ศ㔝࡟ᥦฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞
࠸ࠋఇᴗ᪥࣭฼⏝᫬㛫࣭᫬㛫እ฼⏝ձ ఇᴗ᪥ᅵ᭙ࠊ᪥᭙ࠊᅜẸࡢ⚃᪥࡟㛵ࡍࡿἲᚊ࡛つᐃࡉࢀࡓఇ᪥ࠊ ᭶  ᪥࠿ࡽ⩣ᖺ  ᭶  ᪥ࡲ࡛ࢆࢤࣀ
࣒ศ㔝ࡢఇᴗ᪥࡜ࡍࡿࠋࡓࡔࡋࠊศ㔝㛗ࡀᚲせ࡜ㄆࡵࡿሙྜࠊ⮫᫬࡟ఇᴗ᪥ࢆኚ᭦ࡋࠊཪࡣᐃࡵࡿ
ࡇ࡜ࡀࡁࡿࡇ࡜࡜ࡍࡿࠋղ ᖹ᪥฼⏝᫬㛫ᖹ᪥ ఇᴗ᪥௨እࡢ᪥ ࡢ฼⏝᫬㛫ࡣࠊ ᫬࠿ࡽ  ᫬ࡲ࡛࡜ࡍࡿࠋࡓࡔࡋࠊศ㔝㛗ࡀᚲせ࡜ㄆࡵࡿሙ
ྜࡣ฼⏝᫬㛫ࢆኚ᭦࡛ࡁࡿࡇ࡜࡜ࡍࡿࠋճ ᫬㛫እ฼⏝ᖹ᪥ࡢ฼⏝᫬㛫እ  ᫬㹼⩣ᮅ  ᫬ ࡟ࢤࣀ࣒ศ㔝࡛సᴗࢆ⾜࠺ሙྜࠊ฼⏝⪅ࡣཎ๎࡜ࡋ࡚ヱᙜ᪥ࡢ ᫬ࡲ࡛࡟ࢤࣀ࣒◊✲ศ㔝࡜฼⏝㈐௵⪅ࡢ୧᪉࡬᫬㛫እ฼⏝㢪࠸ࢆᥦฟࡍࡿࡶࡢ࡜ࡍࡿࠋࡲࡓࠊఇ
ᴗ᪥࡟ࢤࣀ࣒ศ㔝࡛సᴗࢆ⾜࠺ሙྜࠊ฼⏝⪅ࡣཎ๎࡜ࡋ࡚฼⏝๓ᖹ᪥ࡢ  ᫬ࡲ࡛࡟ࢤࣀ࣒◊✲ศ㔝࡜฼⏝㈐௵⪅ࡢ୧᪉࡬᫬㛫እ฼⏝㢪࠸ࢆᥦฟࡋࠊ ฼⏝ᶵ✀࡟ࡘࡁ  ෇ࡢ㏣ຍᩱ㔠ࢆ㈇ᢸࡍࡿ
ࡶࡢ࡜ࡍࡿࠋ
ඹྠ฼⏝ᶵჾ࣭ཷクゎᯒࡢ฼⏝ձ ฼⏝ᩱู㡯ࡢᩱ㔠⾲࡟ᚑ࠺ࡶࡢ࡜ࡍࡿࠋղ ฼⏝ᡭ⥆ࡁ฼⏝⪅ࡣࠊࢤࣀ࣒◊✲ศ㔝ࡢ࣮࣒࣮࣍࣌ࢪ࡟࡚ヱᙜᶵჾࡢண⣙ᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ
ண⣙ࡣ  ࣨ᭶ඛࡢ᭶ᮎࡲ࡛ࢆ㝈ᗘ࡜ࡋࠊ㸯ᅇศࡢண⣙ࡣཎ๎࡜ࡋ࡚  ᫬㛫௨ෆ࡜ࡍࡿࠋ
ྠ୍ࢢ࣮ࣝࣉࡢ㐃᪥ண⣙ࡣཎ๎  ᪥ࡲ࡛࡜ࡋࠊ᭦࡟㐃᪥ࡢ౑⏝ࢆᕼᮃࡍࡿሙྜࡣࢤࣀ࣒◊✲ศ㔝࡟┦ㄯࡍࡿࡇ࡜࡜ࡍࡿࠋճ ᶵჾ୙ㄪ࣭ᦆയ
ᶵჾ࡟୙ㄪ࣭ᦆയࡀぢࡽࢀࡓሙྜࠊ฼⏝⪅ࡣ┤ࡕ࡟⟶⌮ᐊ࡟㐃⤡ࡍࡿࡇ࡜࡜ࡋࠊࡑࡢࡲࡲ౑⏝ࡋ࡚ࡣ࡞ࡽ࡞࠸ࠋ
฼⏝⪅ࡢ୙ὀព࡟ࡼࡗ࡚ᶵჾࢆ୙ㄪ࡟ࡋࡓࡾࠊᦆയࡋࡓሙྜࡢಟ⌮㈝ࡣ⤒㈝㈇ᢸ㈐௵⪅ࡀ㈇࠺ࡶࡢ࡜ࡍࡿࠋմ ᶵჾࡢ฼⏝グ㘓౑⏝グ㘓⡙ࡀタ⨨ࡉࢀ࡚࠸ࡿᶵჾࢆ฼⏝ࡋࡓሙྜࡣࠊ฼⏝⪅ࡣࡑࡢ㒔ᗘᚲせ஦㡯ࢆグධࡋ࡞ࡅࢀࡤ
࡞ࡽ࡞࠸ࠋ



ᐇ㦂ᐊ➼ࡢ฼⏝ձ ฼⏝ᩱู㡯ࡢᩱ㔠⾲࡟ᚑ࠺ࡶࡢ࡜ࡍࡿࠋղ ฼⏝ᡭ⥆ࡁ᳜≀⏝ࢢ࣮ࣟࢫ࢟ࣕࣅࢿࢵࢺࠊᐇ㦂ྎࠊᐇ⩦ᐊࠊ◊ಟࢭ࣑ࢼ࣮ᐊࠊ3 ࣞ࣋ࣝᐇ㦂ᐊࠊ᳜≀᱂ᇵᐊࠊ3ᐊࢆ฼⏝ࡋࡼ࠺࡜ࡍࡿሙྜࠊ฼⏝㈐௵⪅ࡣࡑࢀࡒࢀࡢ฼⏝⏦㎸᭩ ู⣬ᵝᘧ➨  ྕ㹼➨  ྕ ࡟ࡼࡾᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋճ ฼⏝⤊஢ࠊ୰Ṇࡢ㝿ࡢཎ≧᚟ᖐ฼⏝ࢆ⤊஢ࡲࡓࡣ୰Ṇࡋࡓ࡜ࡁࠊ฼⏝㈐௵⪅ࡣࠊ㏿ࡸ࠿࡟ᐇ㦂ᐊ➼ࢆཎ≧࡟᚟ᖐࡍࡿ࡜ඹ࡟ࠊ⟶⌮ᐊ࡟ࡑࡢ᪨ࢆሗ࿌ࡋ࡚ࢤࣀ࣒◊✲ศ㔝࡟ࡼࡿ฼⏝⤊஢☜ㄆࢆཷࡅ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋմ ࢤࣀ࣒◊✲ศ㔝ෆࡢ㣧㣗ࢤࣀ࣒◊✲ศ㔝ෆ࡛ࡢ㣧㣗ࡣࠊᡤᐃࡢሙᡤ࡛⾜࠺ࡇ࡜࡜ࡍࡿࠋյ ࢦ࣑ࡢฎ⌮ᐇ㦂➼࡛ฟࡓࢦ࣑ࡣࠊ࡛ࡁࡿ㝈ࡾྛ⮬࡛ᣢࡕᖐࡿࡇ࡜࡜ࡍࡿࠋ

ᶵჾࡢ㈚ฟࡋ
ࢤࣀ࣒◊✲ศ㔝ᡤ᭷ࡢᑠᆺᶵჾࡢ㈚ฟࡋࢆᕼᮃࡍࡿሙྜࠊ฼⏝㈐௵⪅ࡣᙜศ㔝࡟┦ㄯࡢୖࠊᶵჾ㈚ฟ
ࡋ⏦㎸᭩ ู⣬ᵝᘧ➨  ྕ ࡟ࡼࡾᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋ

ᶵჾࡢᣢ㎸ࡳձ ᶵჾࡢᦙධ
฼⏝⪅ࡀࢤࣀ࣒◊✲ศ㔝࡟ᣢࡕ㎸ࡴᶵჾࡣᚲせ᭱ᑠ㝈ࡢᑠᆺᶵჾ࡜ࡋࠊ኱ᆺᶵჾࢆᦙධࡋ࡚ࡣ࡞ࡽ
࡞࠸ࠋᑠᆺᶵჾࢆࢤࣀ࣒◊✲ศ㔝࡟ᦙධࡍࡿሙྜࠊ฼⏝㈐௵⪅ࡣᙜศ㔝࡟┦ㄯࡢୖࠊᑠᆺᶵჾᦙධ⏦㎸᭩ู⣬ᵝᘧ➨  ྕ ࡟ࡼࡾᡭ⥆ࡁࢆ⾜࠺ࡶࡢ࡜ࡍࡿࠋղ ᦙධࡋࡓᑠᆺᶵჾࡢᡤᒓ⾲♧ࠊ⥔ᣢ࣭⟶⌮ᦙධࡋࡓᑠᆺᶵჾ࡟ࡣ฼⏝㈐௵⪅ࡢẶྡࠊ㐃⤡ඛࢆ᫂グࡍࡿࡇ࡜࡜ࡋࠊࡑࡢ⥔ᣢ࣭⟶⌮ࡣࠊ฼⏝㈐௵⪅ࡀ⾜࠺ࡶࡢ࡜ࡍࡿࠋճ ᦙධࡋࡓᑠᆺᶵჾࡢᦙฟ
ᢎㄆᮇ㛫ࡀ‶஢ࡋࡓ࡜ࡁࠊ฼⏝㈐௵⪅ࡣᦙධࡋࡓᑠᆺᶵჾࢆ㏿ࡸ࠿࡟ᦙฟࡋ࡞ࡅࢀࡤ࡞ࡽ࡞࠸ࠋ

ࢤࣀ࣒◊✲Ჷฟධࡾࡢ᪉ἲ
ࢤࣀ࣒◊✲Ჷཬࡧࢤࣀ࣒◊✲Ჷ 5, ᐇ㦂ᐊ࡬ࡢฟධࡾࡣࠊ฼⏝Ⓩ㘓⏦ㄳ᭩ࢆᥦฟࡋㄆドⓏ㘓ࢆ᏶஢ࡋࡓ⫋ဨド࣮࢝ࢻࠊᏛ⏕ド࣮࢝ࢻࠊࡲࡓࡣ )HOLFD ᘧ᪋タ฼⏝ドࢆ౑⏝ࡍࡿࡶࡢ࡜ࡍࡿࠋ

⥭ᛴ஦ែⓎ⏕ࡢ㝿ࡢᥐ⨨⥭ᛴ஦ែࡀⓎ⏕ࡋࡓሙྜࠊ฼⏝⪅ࡣྛ㒊ᒇ࡟⾲♧ࡋ࡚࠶ࡿ⥭ᛴ㑊㞴⤒㊰ࠊ࢞ࢫࡢඖᰦࡢሙᡤࠊ㟁※ࡢ
ሙᡤࢆཧ↷ࡋ࡚㐺ษ࡟ᑐฎࡍࡿࡇ࡜ࠋ
฼⏝ୖࡢၥ㢟Ⅼࡢฎ⌮฼⏝⪅ࡀࢤࣀ࣒◊✲ศ㔝ࡢ฼⏝࡛ၥ㢟ࢆឤࡌࡓሙྜࠊࢤࣀ࣒◊✲ศ㔝ࡢᩍဨࢆ㏻ࡌ࡚ศ㔝㛗࡟⏦ࡋฟࡿࡇ࡜࡜ࡍࡿࠋศ㔝㛗ࡣࠊᚲせ࡟ᛂࡌ࡚ࢭࣥࢱ࣮㛗࡟ሗ࿌ࡍࡿ࡜ඹ࡟㐠Ⴀጤဨ఍࡛ᑂ㆟ࡢୖࠊᨵၿࢆ
ᅗࡿࡶࡢ࡜ࡍࡿࠋ௧࿴  ᖺᗘάື≧ἣሗ࿌ㅮ⩦఍࣭ࢭ࣑ࢼ࣮➼‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ᶵჾㅮ⩦఍ >ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾 &DUO =HLVV/60@ ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦ⅆ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ᶵჾㅮ⩦఍ >ඹ↔Ⅼ࣮ࣞࢨ࣮㢧ᚤ㙾 &DUO =HLVV/60 ⱥㄒ∧@ ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ࣂ࢖࢜ࢺࣞࣥࢻࢭ࣑ࢼ࣮
>㑇ఏᏊ㓄ิゎᯒࢯࣇࢺ &/&*HQRPLFV:RUNEHQFK@ ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦Ỉ㸧ࠥ
⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ࣂ࢖࢜ࢺࣞࣥࢻࢭ࣑ࢼ࣮
>ࢹࢪࢱࣝ 3&5@ཧຍ⪅  ྡ‫ ی‬௧࿴  ᖺ  ᭶  ᪥㸦ᅵ㸧㹼
>୰Ꮫ⏕ࡢࡓࡵࡢ⏕࿨⛉Ꮫయ㦂ࣉࣟࢢ࣒ࣛࠕྩ࡟ࡶ࡛ࡁࡿ '1$ 㚷ᐃࠖ@ཧຍ⪅  ྡ‫ ی‬௧࿴ᖺ᭶᪥㸦ᅵ㸧㹼ࠊ᪥㸦᪥㸧㹼
>㧗ᰯ⏕ࡢࡓࡵࡢ⏕࿨⛉Ꮫయ㦂ࣉࣟࢢ࣒ࣛࠕࢤࣀ࣒ࡗ࡚ఱ㸽ࠖ@ཧຍ⪅  ྡ(2) ゲノム研究分野利用状況

45



㸦㸧ඹྠࢫ࣮࣌ࢫ฼⏝≧ἣᐊྡ㸦ᐊ␒ྕ㸧฼⏝㈐௵⪅㸦Ⓩ㘓␒ྕ㸧᳜≀᱂ᇵᐊ㸦㸧ᑠᒣ ༤அ㸦$*㸧᳜≀⏝ࢢ࣮ࣟࢫ࢟ࣕࣅࢿࢵࢺ

㡲㈡ ᬕஂ㸦/6㸧㹎㸯 ᐊΎỈ ᑗᩥ㸦$*㸧㸦㸧௧࿴  ᖺᗘᴗ⦼ㄽᩥ➼ED-03[1] ґ౽

‫ݲ‬ʀ๼ଞ५Ҳʀ໼޳྆ଢʀௗଢ৵হʀ‫ݻ‬Բ߃ଉʤ2021ʥʁࢀ॑‫ݟ‬๼੐ஏҮͶ͕͜Ζࠅ಼֐པνϑϧ Acheilognathus tabira ྪ͹֮೟ͳҪఽదಝ௅.‫ࢿࡸָྪڗ‬ɾ68, 47–52.
[2] ‫ٳ‬ฯಲᏽʀґ౽ ‫ݲ‬ʀ໼޳྆ଢʀ๼ଞ५Ҳʀ‫ݻ‬Բ߃ଉʤ2021ʥʁࢀ॑‫ݟ‬Յໞઔਭ‫ܧ‬Ͷ͕͜ΖΏΕνψβ Tanakia lanceolata ͹ॵ‫ى‬࿧ɿਫ਼෼ஏཀྵָճճๅɾ76, 70–74.
RS-02[3] Maeda K., Kobayashi H., Palla H.P., Shinzato C., Koyanagi R., Montenegro J., Nagano A.J., Saeki T.,
Kunishima T., Mukai T., Tachihara K., Laudet V., Satoh N., Yamahira K. (2021) ,Do colour-morphs of anamphidromous goby represent different species? Taxonomy of Lentipes (Gobiiformes) from Japan and
Palawan, Philippines, with phylogenomic approaches, Systematics and Biodiversity 19 1080-1112[4] ஝಼߅ଢʀҬ৏ิࣰʀ‫ీݻ‬Ꮾथʀ߶໨կ‫ن‬ʀ޴Ҭ‫ي‬ඛ (2021) ࿪Րࢃ‫Ͳݟ‬൅‫͠ݡ‬ΗͪΠϩϑό͹
ιφΤογϱεϥΤΤΨ.ᗣமྈਖ਼ྪָճๅ, 2021: 189-191.
[5] ޴Ҭ‫ي‬ඛʀਁ෨҂࢜ʀ೉ీఫ࢞ʀీ৏ਜ਼ཾ (2021) ‫ز‬෠‫ݟ‬͹ಊ෼ ᄣ೗ྪʀᗣமྪʀྈਫ਼ྪʀॉ‫ٯ‬ྪɿ‫ز‬෠৿ซऀɾ268ppɿ
MD-06[6] Tomita H., Tanaka K., Hirata A., Okada H., Imai H., Shirakami Y., Ohnishi K., Sugie S., Aoki H., Hatano
Y., Noguchi K., Kanayama T., Niwa A., Suzui N., Miyazaki T., Tanaka T., Akiyama H., Shimizu M.,
Yoshida K., Hara A. (2021) ,Inhibition of FGF10-ERK signal activation suppresses intraductal papillary
neoplasm of the bile duct and its associated carcinomas, Cell Reports 34 108772[7] Enomoto T., Nakane K., Tomioka M., Nakai C., Kawase K., Kato D., Takai M., Iinuma K., Mizutani K.,
Tsuchiya T., Moriyama Y., Miwa K., Hatano Y., Miyazaki T., Koie T. (2021) ,Paraurethral Leiomyoma ina Female Patient who Had Clinical Symptoms with Increase of Tumor Volume: A Case Report, Hinyokika
kiyo. Acta urologica Japonica 67 339-342

[8] Tomioka M., Hishida S., Enomoto T., Kawase K., Nakai C., Kato D., Takai M., Iinuma K., Nakane K.,
Mizutani K., Tsuchiya T., Hatano Y., Miyazaki T., Goto T., Koie T. (2021) ,RENAL CELL CARCINOMA
in the LEFT PELVIC KIDNEY: A CASE REPORT, Acta Urologica Japonica 67 153-156[9] Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda
T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., YamaguchiY., Matsuo M., Hara H., Iwama T., Hara A. (2021) ,Endothelial cell-specific reduction of heparan sulfate
suppresses glioma growth in mice, Discover Oncology 12 50[10] Hatano Y., Ideta T., Hirata A., Hatano K., Tomita H., Okada H., Shimizu M., Tanaka T., Hara A.
(2021) ,Virus-driven carcinogenesis, Cancers 13 2625
[11] Kanayama T., Taniguchi T., Tomita H., Niwa A., Noguchi K., Matsuo M., Imaizumi Y., Kuroda T., Hatano
Y., Okazaki I., Kato T., Hara A. (2021) ,Aldh1 and sall4 expression in cell block samples from patientswith lung adenocarcinoma and malignant pleural effusion, Diagnostics 11 1463
[12] Hatano Y., Tamada M., Shiga T., Niwa A., Kanayama T., Noguchi K., Morishige K.-I., Tomita H., Hara
A. (2021) ,Clinically relevant umbilical cord inflammation identified based on CD15-associated vasculitis
patterning, Placenta 108 39-46[13] Kawaguchi M., Kato H., Hatano Y., Tomita H., Hara A., Miyazaki T., Matsuo M. (2021) ,Magnetic
resonance imaging findings of extrauterine high-grade serous carcinoma based on new pathologic criteria
for primary site assignment, Acta Radiologica 62 687-694[14] Miyai M, Kanayama T, Hyodo F, Kinoshita T, Ishihara T, Okada H, Suzuki H, Takashima S, Wu Z, Hatano
Y, Egashira Y, Enomoto Y, Nakayama N, Soeda A, Yano H, Hirata A, Niwa M, Sugie S, Mori T, Maekawa
Y, Iwama T, Matsuo M, Hara A, Tomita H. (2021) ,Glucose transporter Glut1 controls diffuse invasion
phenotype with perineuronal satellitosis in diffuse glioma microenvironment, Neurooncol Adv. 2020 Oct
30;3(1):vdaa150
MD-08[15] Tanaka S., Abe C., Abbott S.B.G., Zheng S., Yamaoka Y., Lipsey J.E., Skrypnyk N.I., Yao J., Inoue T.,
Nash W.T., Stornetta D.S., Rosin D.L., Stornetta R.L., Guyenet P.G., Okusa M.D. (2021) ,Vagus nerve
stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice fromkidney injury, Proceedings of the National Academy of Sciences of the United States of America 118
e2021758118[16] Aoki H., Abe C., Hara A., Miyazaki T., Morita H., Kunisada T. (2021) ,Induced genetic ablation of Rest
leads to the alteration of stimulus-induced response of the vagal nerve, Genes to Cells 26 45-55

MD-09[17] Kimura A., Kato S., Takekoshi A., Yoshikura N., Yanagida N., Kitaguchi H., Akiyama D., Shimizu H.,
Kakita A., Shimohata T. (2021) ,Autoimmune glial fibrillary acidic protein astrocytopathy resembling
isolated central nervous system lymphomatoid granulomatosis, Journal of Neuroimmunology 361 577748[18] Nakamura S., Fujioka T., Kawashima S., Kawaguchi T., Mizuno M., Omura M., Okita K., Kimura A.,
Shimohata T., Matsukawa N. (2021) ,Self-remitting Elevation of Adenosine Deaminase Levels in the
Cerebrospinal Fluid with Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report andReview of the Literature, Internal Medicine 60 3031-3036[19] Adachi H., Shiomi Y., Kimura A., Shimohata T., Yoneda Y., Kageyama Y. (2021) ,A case of autoimmune
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MD-11[20] Shimamori Y., Pramono A.K., Kitao T., Suzuki T., Aizawa S.-I., Kubori T., Nagai H., Takeda S., Ando H.
(2021) ,Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical
Isolates from Patients with Atopic Dermatitis, Current Microbiology 78 1267-1276
MD-19[21] Takeuchi K., Ogawa H., Kuramitsu N., Akaike K., Goto A., Aoki H., Lassar A., Suehara Y., Hara A.,
Matsumoto K., Akiyama H. (2021) ,Colchicine protects against cartilage degeneration by inhibiting
MMP13 expression via PLC-ȖSKRVSKRU\ODWLRQ2VWHRDUWKULWLVDQG&DUWLODJH-1574
MD-20[22] Nishihira J., Nishimura M., Kurimoto M., Kagami-Katsuyama H., Hattori H., Nakagawa T., Muro T.,
Kobori M. (2021) ,The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive
decline in healthy elderly people: A randomized, double-blind, placebo-controlled, parallel-groupcomparative clinical trial, Journal of Clinical Biochemistry and Nutrition 69 203-215
MD-22[23] Muramatsu-Maekawa Y., Kawakami K., Fujita Y., Takai M., Kato D., Nakane K., Kato T., Tsuchiya T.,
Koie T., Miura Y., Ito M., Mizutani K. (2021) ,Profiling of serum extracellular vesicles reveals miRNA4525 as a potential biomarker for advanced renal cell carcinoma, Cancer Genomics and Proteomics 18 253259[24] Kawakami K., Fujita Y., Kato T., Horie K., Koie T., Umezawa K., Tsumoto H., Miura Y., Katagiri Y.,
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expressing prostate-specific membrane antigen in urologic malignancies, Scientific Reports 11 15000

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(2021) ,Kartogenin inhibits prostate cancer cell growth through Smad2 activation and decreases androgen
receptor nuclear localization, Anticancer Research 41 4753-4759[26] Hishida S., Kawakami K., Fujita Y., Kato T., Takai M., Iinuma K., Nakane K., Tsuchiya T., Koie T., MiuraY., Ito M., Mizutani K. (2021) ,Proteomic analysis of extracellular vesicles identified PI3K pathway as apotential therapeutic target for cabazitaxel-resistant prostate cancer, Prostate 81 592-602[27] Iinuma K., Kawakami K., Mizutani K., Fujita Y., Yamaguchi T., Ito M., Kumano T., Matsuo M., Nakano
M., Koie T., Ito M., Kato T. (2021) ,MiRNA-93 in serum extracellular vesicles before and after low dose
rate prostate brachytherapy, Anticancer Research 41 2411-2418
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Mouse Line, Dct::CreERT2, Results in Disrupted Stem Cell Renewal and Pigmentation Defects, Journalof Investigative Dermatology 141 1363-1366.e9.
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cancer-associated carbohydrate antigen on annexin A2 protein, Journal of Molecular Medicine 99 11151123[32] Yasufuku I., Saigo C., Kito Y., Yoshida K., Takeuchi T. (2021) ,Prognostic significance of LDL receptorrelated protein 1B in patients with gastric cancer, Journal of Molecular Histology 52 165-172[33] Sakuratani T., Takeuchi T., Yasufuku I., Iwata Y., Saigo C., Kito Y., Yoshida K. (2021) ,Downregulationof ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakirimediated apoptosis pathway, Virchows Archiv 478 401-411[34] Iwata Y., Yasufuku I., Saigo C., Kito Y., Takeuchi T., Yoshida K. (2021) ,Anti-fibrotic properties of an
adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma,
Journal of Cancer 12 1161-1168

[35] Kawashima K., Kito Y., Tochii K., Kimura M., Takeda T., Sekino T., Ikeda T., Takeuchi T. (2021) ,A
unique case of splenic tumor exhibiting a serous carcinoma phenotype, SAGE Open Medical Case Reports
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vesicle transcytosis and albuminuria in apc c-terminal deficiency mice with puromycin-induced nephrotic
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Molecular Morphology 54 302-303[38] Yamada N.O., Senda T. (2021) ,Circulating microRNA-92a-3p in colorectal cancer: a review, Medical
Molecular Morphology 54 193-202[39] Wenduerma, Yamada N.O., Wang T., Senda T. (2021) ,A further study on a disturbance of intestinal
epithelial cell population and kinetics in APC1638T mice, Medical Molecular Morphology 54 203-215[40] Li C., Onouchi T., Hirayama M., Sakai K., Matsuda S., Yamada N.O., Senda T. (2021) ,Morphologicaland functional abnormalities of hippocampus in APC 1638T/1638T mice, Medical Molecular Morphology
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in gastric cancer, Scientific Reports 11 14134[42] Nonaka K., Saio M., Umemura N., Kikuchi A., Takahashi T., Osada S., Yoshida K. (2021) ,Th1
polarization in the tumor microenvironment upregulates the myeloid-derived suppressor-like function ofmacrophages, Cellular Immunology 369 104437[43] Tsuburaya A., Guan J., Yoshida K., Kobayashi M., Yoshino S., Tanabe K., Yoshikawa T., Oshima T.,
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(2021) ,Postoperative changes in plasma miR21-5p as a novel biomarker for colorectal cancer recurrence:
A prospective study, Cancer Science 112 4270-4280[45] Suetsugu T., Mori R., Futamura M., Fukada M., Tanaka H., Yasufuku I., Sato Y., Iwata Y., Imai T., Imai
H., Tanaka Y., Okumura N., Matsuhashi N., Takahashi T., Yoshida K. (2021) ,Mechanism of acquired5FU resistance and strategy for overcoming 5FU resistance focusing on 5FU metabolism in colon cancer
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breast cancer, Gland Surgery 10 154-165[48] Kato T., Matsuhashi N., Tomita H., Takahashi T., Iwata Y., Fukada M., Yasufuku I., Suetsugu T., Imai T.,
Mori R., Imai H., Tanaka Y., Okumura N., Hara A., Yoshida K. (2021) ,MYC Up-regulation is a usefulbiomarker for preoperative neoadjuvant chemotherapy combined with anti-EGFR in liver metastasis fromcolorectal cancer, In Vivo 35 203-213[49] Tomita H., Tanaka K., Hirata A., Okada H., Imai H., Shirakami Y., Ohnishi K., Sugie S., Aoki H., Hatano
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Yoshida K., Hara A. (2021) ,Inhibition of FGF10-ERK signal activation suppresses intraductal papillary
neoplasm of the bile duct and its associated carcinomas, Cell Reports 34 108772[50] Yasufuku I., Saigo C., Kito Y., Yoshida K., Takeuchi T. (2021) ,Prognostic significance of LDL receptorrelated protein 1B in patients with gastric cancer, Journal of Molecular Histology 52 165-172[51] Sakuratani T., Takeuchi T., Yasufuku I., Iwata Y., Saigo C., Kito Y., Yoshida K. (2021) ,Downregulationof ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakirimediated apoptosis pathway, Virchows Archiv 478 401-411[52] Iwata Y., Yasufuku I., Saigo C., Kito Y., Takeuchi T., Yoshida K. (2021) ,Anti-fibrotic properties of an
adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma,
Journal of Cancer 12 1161-1168
MD-60[53] Sampei S., Okada H., Tomita H., Takada C., Suzuki K., Kinoshita T., Kobayashi R., Fukuda H., Kawasaki
Y., Nishio A., Yano H., Muraki I., Fukuda Y., Suzuki K., Miyazaki N., Watanabe T., Doi T., Yoshida T.,
Suzuki A., Yoshida S., Kushimoto S., Ogura S. (2021) ,Endothelial Glycocalyx Disorders May Be
Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model, Frontiers in
Cell and Developmental Biology 9 623582[54] Sampei S., Okada H., Tomita H., Suzuki A., Nawa T., Ogura S. (2021) ,Point of tangency between
coronavirus disease and endothelial injury, International Journal of Emergency Medicine 14 76[55] Yamada N., Kitagawa Y., Yoshida T., Nachi S., Okada H., Ogura S. (2021) ,Validity and risk factor
analysis for helicopter emergency medical services in Japan: a pilot study, BMC Emergency Medicine 2187[56] Matsubara T., Umemura Y., Ogura H., Matsuura H., Ebihara T., Matsumoto H., Yamakawa K., Shimizu
K., Okada H., Shimazu T. (2021) ,Bone Marrow-Derived Mononuclear Cell Transplantation Can Reduce
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Nakashima Y., Chiba N., Yoshimura G., Kamidani R., Miura T., Oiwa H., Yamaji F., Mizuno Y., Miyake
T., Kitagawa Y., Fukuta T., Doi T., Suzuki A., Yoshida T., Tetsuka N., Yoshida S., Ogura S.
(2021) ,Measuring the Concentration of Serum Syndecan-1 to Assess Vascular Endothelial Glycocalyx
Injury During Hemodialysis, Frontiers in Medicine 8 791309[60] Kitagawa Y., Kawamura I., Suzuki K., Okada H., Ishihara T., Tomita H., Suzuki K., Takada C., Sampei
S., Kano S., Kondo K., Asano H., Wakayama Y., Kamidani R., Kawasaki Y., Fukuda H., Nishio A., Miyake
T., Fukuta T., Yasuda R., Oiwa H., Kakino Y., Miyazaki N., Watanabe T., Yoshida T., Doi T., Suzuki A.,
Yoshida S., Matsuo H., Ogura S. (2021) ,Serum syndecan-1 concentration in hospitalized patients withheart failure may predict readmission-free survival, PLoS ONE 16 e0260350[61] Kamidani R., Miyake T., Okada H., Yoshimura G., Kusuzawa K., Miura T., Shimaoka R., Oiwa H., Yamaji
F., Mizuno Y., Yasuda R., Kitagawa Y., Fukuta T., Ishihara T., Shiga T., Okamoto H., Tachi M., Shiba M.,
Kanda N., Nachi S., Doi T., Yoshida T., Yoshida S., Morishige K., Ogura S. (2021) ,Effect of
cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study,
Scientific Reports 11 18458[62] Kamidani R., Kumada K., Okada H., Yoshimura G., Kanayama T., Tomita H., Miura T., Oiwa H., Mizuno
Y., Kitagawa Y., Yasuda R., Fukuta T., Miyake T., Doi T., Yoshida T., Yoshida S., Hara A., Ogura S.
(2021) ,Postmortem diagnosis of pulmonary tumor thrombotic microangiopathy with rapid exacerbation ina patient with gastric cancer: a case report, International Journal of Emergency Medicine 14 53[63] Suzuki K., Okada H., Sumi K., Tomita H., Kobayashi R., Ishihara T., Kakino Y., Suzuki K., YoshiyamaN., Yasuda R., Kitagawa Y., Fukuta T., Miyake T., Okamoto H., Doi T., Yoshida T., Yoshida S., Ogura
S., Suzuki A. (2021) ,Serum syndecan-1 reflects organ dysfunction in critically ill patients, Scientific
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[64] Suzuki K., Okada H., Tomita H., Sumi K., Kakino Y., Yasuda R., Kitagawa Y., Fukuta T., Miyake T.,
Yoshida S., Suzuki A., Ogura S. (2021) ,Possible involvement of Syndecan-1 in the state of COVID-19
related to endothelial injury, Thrombosis Journal 19 5[65] Kamidani R., Okada H., Kitagawa Y., Kusuzawa K., Ichihashi M., Kakino Y., Oiwa H., Yasuda R., Fukuta
T., Yoshiyama N., Miyake T., Okamoto H., Suzuki K., Yamada N., Doi T., Yoshida T., Ushikoshi H.,
Kumada K., Yoshida S., Ogura S. (2021) ,Severe heat stroke complicated by multiple cerebral infarctions:a case report, Journal of Medical Case Reports 15 24[66] Okamoto H., Muraki I., Okada H., Tomita H., Suzuki K., Takada C., Wakayama Y., Kuroda A., Fukuda
H., Kawasaki Y., Nishio A., Matsuo M., Tamaoki Y., Inagawa R., Takashima S., Taniguchi T., Suzuki A.,
Suzuki K., Miyazaki N., Kakino Y., Yasuda R., Fukuta T., Kitagawa Y., Miyake T., Doi T., Yoshida T.,
Yoshida S., Ogura S. (2021) ,Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome
in Experimental Endotoxemia, American Journal of Pathology 191 1526-1536[67] Tomita H., Tanaka K., Hirata A., Okada H., Imai H., Shirakami Y., Ohnishi K., Sugie S., Aoki H., Hatano
Y., Noguchi K., Kanayama T., Niwa A., Suzui N., Miyazaki T., Tanaka T., Akiyama H., Shimizu M.,
Yoshida K., Hara A. (2021) ,Inhibition of FGF10-ERK signal activation suppresses intraductal papillary
neoplasm of the bile duct and its associated carcinomas, Cell Reports 34 108772[68] Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda
T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., YamaguchiY., Matsuo M., Hara H., Iwama T., Hara A. (2021) ,Endothelial cell-specific reduction of heparan sulfate
suppresses glioma growth in mice, Discover Oncology 12 50[69] Hatano Y., Ideta T., Hirata A., Hatano K., Tomita H., Okada H., Shimizu M., Tanaka T., Hara A.
(2021) ,Virus-driven carcinogenesis, Cancers 13 2625
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after stent assist coiling dependent on clopidogrel response, BMC Neurology 21 247[71] Kinoshita T., Tomita H., Okada H., Niwa A., Hyodo F., Kanayama T., Matsuo M., Imaizumi Y., Kuroda
T., Hatano Y., Miyai M., Egashira Y., Enomoto Y., Nakayama N., Sugie S., Matsumoto K., YamaguchiY., Matsuo M., Hara H., Iwama T., Hara A. (2021) ,Endothelial cell-specific reduction of heparan sulfate
suppresses glioma growth in mice, Discover Oncology 12 50[72] Sampei S., Okada H., Tomita H., Takada C., Suzuki K., Kinoshita T., Kobayashi R., Fukuda H., Kawasaki
Y., Nishio A., Yano H., Muraki I., Fukuda Y., Suzuki K., Miyazaki N., Watanabe T., Doi T., Yoshida T.,
Suzuki A., Yoshida S., Kushimoto S., Ogura S. (2021) ,Endothelial Glycocalyx Disorders May Be
Associated With Extended Inflammation During Endotoxemia in a Diabetic Mouse Model, Frontiers in
Cell and Developmental Biology 9 623582

MD-63[73] Kitao T., Arasaki K., Nagai H., Kubori T. (2021) ,Protocol for imaging proteins associated with Legionellacontaining vacuoles in host cells, STAR Protocols 2 100410[74] Shimamori Y., Pramono A.K., Kitao T., Suzuki T., Aizawa S.-I., Kubori T., Nagai H., Takeda S., Ando H.
(2021) ,Isolation and Characterization of a Novel Phage SaGU1 that Infects Staphylococcus aureus Clinical
Isolates from Patients with Atopic Dermatitis, Current Microbiology 78 1267-1276[75] Kawabata M., Matsuo H., Koito T., Murata M., Kubori T., Nagai H., Tagaya M., Arasaki K.
(2021) ,Legionella hijacks the host Golgi-to-ER retrograde pathway for the association of Legionellacontaining vacuole with the ER, PLoS Pathogens 17 e1009437[76] Shimamori Y., Mitsunaka S., Yamashita H., Suzuki T., Kitao T., Kubori T., Nagai H., Takeda S., Ando H.
(2021) ,Staphylococcal phage in combination with staphylococcus epidermidis as a potential treatment forstaphylococcus aureus-associated atopic dermatitis and suppressor of phage-resistant mutants, Viruses 137[77] ๼ඎޮӵɼ‫ٳ‬ຉஒࢢɼӮҬ޼ध

(2021)

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ঘ๖༎ૻεητϞ͹૤ࡠ Journal of Japanese Biochemical Society 93(6): 835-839
EG-02[78] Tahara N., Tachibana I., Takeo K., Yamashita S., Shimada A., Hashimoto M., Ohno S., Yokogawa T.,
Nakagawa T., Suzuki F., Ebihara A. (2021) ,Boosting Auto-Induction of Recombinant Proteins inEscherichia coli with Glucose and Lactose Additives, Protein and peptide letters 28 1180-1190
EG-03[79] Sai M. (2021) ,A Tetraarylpyrrole-Based Phosphine Ligand for the Palladium-Catalyzed Amination of Aryl
Chlorides, Advanced Synthesis and Catalysis 363 5422-5428[80] Sai M. (2021) ,Potassium Base-Promoted Diastereoselective Synthesis of 1,3-Diols from Allylic Alcohols
and Aldehydes through a Tandem Allylic-Isomerization/Aldol–Tishchenko Reaction, Chemistry - An
Asian Journal 16 4053-4056[81] Sai M., Kurouchi H. (2021) ,Potassium Base-&DWDO\]HG 0LFKDHO $GGLWLRQV RI $OO\OLF $OFRKROV WR ĮȕUnsaturated Amides: Scope and Mechanistic Insights, Advanced Synthesis and Catalysis 363 3585-3591
EG-05[82] Kubota Y., Nakazawa M., Lee J., Naoi R., Tachikawa M., Inuzuka T., Funabiki K., Matsui M., Kim T.
(2021) ,Synthesis of near-infrared absorbing and fluorescent bis(pyrrol-2-yl)squaraines and their
halochromic properties, Organic Chemistry Frontiers 8 6226-6243[83] Funabiki K., Yamada K., Matsueda H., Arisawa Y., Agou T., Kubota Y., Inuzuka T., Wasada H.
(2021),Perfluorophenyl-Perfluorophenyl

Stacking-Promoted



Aggregation-Induced

EmissionEnhancement of Crystalline 5-Aryloxy-3H-Indole, European Journal of Organic Chemistry 2021 13441350[84] Funabiki K., Gotoh T., Kani R., Inuzuka T., Kubota Y. (2021) ,Highly diastereo- And enantioselective
organocatalytic synthesis of trifluoromethylated erythritols based on thein situgeneration of unstable
trifluoroacetaldehyde, Organic and Biomolecular Chemistry 19 1296-1304
EG-07[85] Shirakami N., Kawaki Y., Higashi S.L., Shibata A., Kitamura Y., Hanifah S.A., Wah L.L., Ikeda M.
(2021) ,Introduction of an Oxidation-responsive 4-Boronobenzyl Group into an Oligonucleotide through a
Postmodification Approach, Chemistry Letters 50 1412-1415[86] Shirakami N., Higashi S.L., Kawaki Y., Kitamura Y., Shibata A., Ikeda M. (2021) ,Construction of areduction-responsive oligonucleotide via a post-modification approach utilizing 4-nitrophenyl
diazomethane, Polymer Journal 53 741-746[87] Ohtomi T., Higashi S.L., Mori D., Shibata A., Kitamura Y., Ikeda M. (2021) ,Effect of side chain phenylgroup on the self-assembled morphology of dipeptide hydrazides, Peptide Science 113 e24200
EG-08[88] Fukawa Y., Mizuno Y., Kawade K., Mitsukura K., Yoshida T. (2021) ,Novel (S)-selective hydrolase fromarthrobacter sp. k5 for kinetic resolution of cyclic amines, Catalysts 11 809
EG-09[89] Heishima K., Sugito N., Soga T., Nishikawa M., Ito Y., Honda R., Kuranaga Y., Sakai H., Ito R., Nakagawa
T., Ueda H., Akao Y. (2021) ,Petasin potently inhibits mitochondrial complex I–based metabolism that
supports tumor growth and metastasis, Journal of Clinical Investigation 131 e139933[90] Nomura T.K., Heishima K., Sugito N., Sugawara R., Ueda H., Yukihiro A., Honda R. (2021) ,Specificinhibition of oncogenic RAS using cell-permeable RAS-binding domains, Cell Chemical Biology 28 15811589 e6EG-15[91] Sonawane A.D., Sonawane R.A., Ninomiya M., Koketsu M. (2021) ,Diorganyl diselenides: A powerfultool for the construction of selenium containing scaffolds, Dalton Transactions 50 12764-12790[92] Itoh T., Fujita S., Koketsu M., Hashizume T. (2021) ,Citrulluside H and citrulluside T from youngwatermelon fruit attenuate ultraviolet B radiation-induced matrix metalloproteinase expression through thescavenging of generated reactive oxygen species in human dermal fibroblasts, Photodermatology
Photoimmunology and Photomedicine 37 386-394[93] Ukiya M., Motegi K., Sato D., Kimura H., Satsu H., Koketsu M., Ninomiya M., Myint L.M., Nishina A.
(2021) ,Effect of Compounds from Moringa oleifera Lam. on in Vitro Non-Alcoholic Fatty Liver Disease(NAFLD) Model System, Chemistry and Biodiversity 18 e2100243

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K.M.N.,

Sonawane

A.D.,

KoketsuM.

(2021),Synthesisofselenated

tetracyclic

indoloazulenesviaiodine and diorganyl diselenides, Organic and Biomolecular Chemistry 19 3199-3206[95] Mandela J., Trisunaryanti W., Triyono, Koketsu M., Fatmawati D.A. (2021) ,Hydrochloric acid and/or
sodium hydroxide-modified zeolite y for catalytic hydrotrHDWLQJRIĮ-cellulose bio-oil, Indonesian Journalof Chemistry 21 787-796[96] Sonawane A.D., Koketsu M. (2021) ,Organocatalysed synthesis of selenium containing scaffolds, Current
Organocatalysis 8 5-26
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phosphitylation of the carbonyl group, Bioorganic and Medicinal Chemistry Letters 54 128439[98] Oka N., Kanda M., Furuzawa M., Arai W., Ando K. (2021) ,Serendipitous One-Step Synthesis of
Cyclopentene DerivativeVIURP ƍ-Deoxy-ƍ-heteroarylsulfonylnucleosides as Nucleoside-Derived JuliaKocienski Reagents, Journal of Organic Chemistry 86 16684-16698[99] Oka N., Suzuki K., Mori A., Ando K. (2021) ,Stereoselective Synthesis of 1,2-cis-Glycosyl Sulfones andTheir Application in One-Pot Julia Olefination for the Synthesis of exo-Glycals, European Journal of
Organic Chemistry 2021 5922-5933[100]

Oka N., Mori A., Suzuki K., Ando K. (2021) ,Stereoselective Synthesis of Ribofuranoid exo-Glycals

by One-Pot Julia Olefination Using Ribofuranosyl Sulfones, Journal of Organic Chemistry 86 657-673
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Hirata Y., Tsunekawa Y., Takahashi M., Oh-hashi K., Kawaguchi K., Hayazaki M., Watanabe M.,

Koga K.-I., Hattori Y., Takemori H., Furuta K. (2021) ,Identification of novel neuroprotective N,Ndimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes,
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Hirata Y., Motoyama M., Kimura S., Takashima M., Ikawa T., Oh-hashi K., Kamatari Y.O.

(2021) ,Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stressand protein aggregation, European Journal of Pharmacology 912 174572[103]

Oh-hashi K., Hasegawa T., Mizutani Y., Takahashi K., Hirata Y. (2021) ,Elucidation of brefeldin A-

induced ER and Golgi stress responses in Neuro2a cells, Molecular and Cellular Biochemistry 476 38693877[104]

Oh-hashi K., Hasegawa T., Naruse Y., Hirata Y. (2021) ,Molecular characterization of mouse CREB3

regulatory factor in Neuro2a cells, Molecular Biology Reports 48 5411-5420[105]

Ikawa T., Sato M., Oh-hashi K., Furuta K., Hirata Y. (2021) ,Oxindole–curcumin hybrid compoundHQKDQFHVWKHWUDQVFULSWLRQRIȖ-glutamylcysteine ligase, European Journal of Pharmacology 896 173898

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Sec16B in Neuro2a cells, Molecular and Cellular Biochemistry 476 35-44
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Takahashi Y., Serada S., Ohkawara T., Fujimoto M., Hiramatsu K., Ueda Y., Kimura T., Takemori

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Hibi M., Nakagawa T., Hayakawa T., Yanase E., Shimada M. (2021) ,Dietary supplementation with

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Hibi M., Sugiura S., Nakagawa T., Hayakawa T., Shimada M. (2021) ,Effects of dietary

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Akther J., Das A., Rahman M.A., Saha S.K., Hosen M.I., Ebihara A., Nakagawa T., Suzuki F., Nabi

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Hashimoto M., Fukamizu A., Nakagawa T., Kizuka Y. (2021) ,Roles of protein arginine

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Tani A., Mitsui R., Nakagawa T. (2021) ,Discovery of lanthanide-dependent methylotrophy andscreening methods for lanthanide-dependent methylotrophs, Methods in Enzymology 650 1-18
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Ma P., Takashima S., Fujita C., Yamada S., Oshima Y., Cai H.-L., Yurimoto H., Sakai Y., Hayakawa

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Sheng X., Tanaka M., Katagihara R., Hashimoto M., Nagaoka S., Matsui T. (2021) ,Novel Approachfor Simultaneous Analysis of Peptide Metabolites from Orally Administered Glycinin in Rat Bloodstream
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0DWVXL 7   ,GHQWLILFDWLRQ RI SHSWLGHV LQ EORRG IROORZLQJ RUDO DGPLQLVWUDWLRQ RI ȕ-conglycinin to
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ཤ, (2021) ணΩτΫϱͶΓΖఁືౕϨϛνϱϏέ࣯ʤLDLʥण༲ର‫׈‬੓Կ͹෾ࢢ‫ߑؽ‬,ೖຌϛϨϓΥόʖϩָճࡸࢿ 10, 3-7ʤ૱ઈʥ
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ཤ, ࡖ໼৿ଢ (2021) ৱ඾‫ؽ‬೵੓ϘϕοχͳϘϕοχ༎ૻ୴ର, ੊ֆॵ͹ࢹ࣯େःր

વζϘϕοχ FPʤPhe-Proʥ͹ࡠ༽‫ߑؽ‬. Կָͳਫ਼෼ 59, 367-368ʤ૱ઈʥ
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Kamishina H., Nakano Y., Nozue Y., Nakata K., Kimura S., Drury A.G., Maeda S.

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Kobatake Y., Nakata K., Sakai H., Sasaki J., Yamato O., Takashima S., Nishii N., Maeda S., Islam

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Kuwahara Y., Yoshizaki K., Nishida H., Kamishina H., Maeda S., Takano K., Fujita N., Nishimura

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Nakata K., Namiki M., Kobatake Y., Nishida H., Sakai H., Yamato O., Urushitani M., Maeda S.,

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Tanaka N., Kanei T., Iwata M., Kawabe M., Kamishina H., Murakami M., Sakai H., Maeda S.

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Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

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Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

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Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

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Abe J., Iritani R., Tsuchida K., Kamimura Y., West S.A. (2021) ,A solution to a sex ratio puzzle in

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Kakumu Y., Nguyen T.M.T., Yamauchi K., Mitsunaga T. (2021) ,New benzoic acid and caffeoyl

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Horii K., Ehara Y., Shiina T., Naitou K., Nakamori H., Horii Y., Shimaoka H., Saito S., Shimizu Y.

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Sarkar S., Homma T., Onouchi S., Shimizu Y., Shiina T., Nabeka H., Matsuda S., Saito S.

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Yoshizaki K., Hirata A., Matsushita H., Nishii N., Kawabe M., Mori T., Sakai H. (2021) ,PCR-based

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Tanaka N., Kanei T., Iwata M., Kawabe M., Kamishina H., Murakami M., Sakai H., Maeda S.

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Nakagawa K., Kumano H., Kitamura Y., Kuwata K., Tanaka E., Fukushi H. (2021) ,Complete genome

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G.S., Ziatdinov V.B., Khammadov N.I., Safina R.F., Salmanova G.R., Akhmedova G.M., Khaertynov K.S.,
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Saito T., Kitamura Y., Tanaka E., Ishigami I., Taniguchi Y., Moribe J., Kitoh K., Takashima Y.

(2021) ,Spatial distribution of anti-Toxoplasma gondii antibody-positive wild boars in Gifu Prefecture,
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Saito T., Masatani T., Kitoh K., Takashima Y. (2021) ,Releasing latent Toxoplasma gondii cysts fromhost cells to the extracellular environment induces excystation, International Journal for Parasitology 51
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Saito T., Hayashi K., Hayashi K., Akita Y., Une Y., Kuroki T., Shibahara T., Takashima Y.

(2021) ,Morphological observation and first molecular characterization of Grassenema procaviae Petter,
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Hayashi K., Kitayama C., Saito T., Ohari Y., Hayashi K., Kondo S., Takashima Y., Kuroki T.,

Shibahara T., Itagaki T. (2021) ,Detection and molecular characteristics of Pyelosomum cochlear (Digenea:
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Kitayama C., Hayashi K., Hayashi K., Igarashi H., Kondo S., Ogawa R., Hashimoto T., Okubo S.,

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Ohari Y., Hayashi K., Takashima Y., Itagaki T. (2021) ,Do aspermic (parthenogenetic) Fasciola forms

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Waki T., Ohari Y., Hayashi K., Moribe J., Matsuo K., Takashima Y. (2021) ,The first detection of

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Shoshi Y., Kazato K., Maeda T., Takashima Y., Watari Y., Matsumoto Y., Miyashita T., Sanjoba C.

(2021) ,Prevalence of serum antibodies to toxoplasma gondii in free-ranging cats on tokunoshima island,japan, Journal of Veterinary Medical Science 83 333-337
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(2021) ,Population genetics analysis of Phytophthora nicotianae associated with heart rot in pineapple
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(2021) ,Advanced diagnostic system and introduction of newborn screening of adrenoleukodystrophy andperoxisomal disorders in Japan, International Journal of Neonatal Screening 7 58
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Takashima S., Takemoto S., Toyoshi K., Ohba A., Shimozawa N. (2021) ,Zebrafish model of human

Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene
expression changes, Molecular Genetics and Metabolism 133 307-323[289]

Kubota K., Kawai H., Takashima S., Shimohata T., Otsuki M., Ohnishi H., Shimozawa N.

(2021) ,Clinical evaluation of childhood cerebral adrenoleukodystrophy with balint's symptoms, Brain andDevelopment 43 396-401[290]

Fujiwara Y., Hama K., Shimozawa N., Yokoyama K. (2021) ,Glycosphingolipids with very long-

chain fatty acids accumulate in fibroblasts from adrenoleukodystrophy patients, International Journal of
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Horii K., Ehara Y., Shiina T., Naitou K., Nakamori H., Horii Y., Shimaoka H., Saito S., Shimizu Y.

(2021) ,Sexually dimorphic response of colorectal motility to noxious stimuli in the colorectum in rats,
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(2021) ,Fusobacterium watanabei sp. nov. As additional species within the genus Fusobacerium, isolated
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(2021) ,5,11-Diazadibenzo[hi,qr]tetracene: Synthesis, Properties, and Reactivity toward Nucleophilic
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(2021),Perfluorophenyl-Perfluorophenyl

Stacking-Promoted

Aggregation-Induced

Emission

Enhancement of Crystalline 5-Aryloxy-3H-Indole, European Journal of Organic Chemistry 2021 13441350[307]

Funabiki K., Gotoh T., Kani R., Inuzuka T., Kubota Y. (2021) ,Highly diastereo- And enantioselective

organocatalytic synthesis of trifluoromethylated erythritols based on thein situgeneration of unstable
trifluoroacetaldehyde, Organic and Biomolecular Chemistry 19 1296-1304
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Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

Y. (2021) ,Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected
cattle, Scientific Reports 11 2951
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Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

(2021) ,Putative internal control genes in bovine milk small extracellular vesicles suitable for normalizationin quantitative real time-polymerase chain reaction, Membranes 11 933[310]

Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

(2021) ,Comprehensive proteomic analysis revealed a large number of newly identified proteins in thesmall extracellular vesicles of milk from late-stage lactating cows, Animals 11 2506
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Hirata Y., Motoyama M., Kimura S., Takashima M., Ikawa T., Oh-hashi K., Kamatari Y.O.

(2021) ,Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stressand protein aggregation, European Journal of Pharmacology 912 174572[312]

Tanaka N., Kimura S., Kamatari Y.O., Nakata K., Kobatake Y., Inden M., Yamato O., Urushitani M.,

Maeda S., Kamishina H. (2021) ,In vitro evidence of propagation of superoxide dismutase-1 protein
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Ma P., Takashima S., Fujita C., Yamada S., Oshima Y., Cai H.-L., Yurimoto H., Sakai Y., Hayakawa

T., Shimada M., Ning X., Wei B., Nakagawa T. (2021) ,Fatty acid composition of the methylotrophic yeast
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Maeda M., Suzuki M., Takashima S., Sasaki T., Oh-Hashi K., Takemori H. (2021) ,The new live

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Tanabe K., Takashima S., Iida H. (2021) ,Changes in the gene expression in mouse astrocytes inducedby pulsed radiofrequency: A preliminary study, Neuroscience Letters 742 135536

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Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Kitamura Y., Shimizu K., Okada A., Inoshima

Y. (2021) ,Proteomic profiling of milk small extracellular vesicles from bovine leukemia virus-infected
cattle, Scientific Reports 11 2951
[317]

Rahman M.M., Takashima S., Kamatari Y.O., Badr Y., Shimizu K., Okada A., Inoshima Y.

(2021) ,Putative internal control genes in bovine milk small extracellular vesicles suitable for normalizationin quantitative real time-polymerase chain reaction, Membranes 11 933[318]

Rahman M.M., Takashima S., Kamatari Y.O., Shimizu K., Okada A., Inoshima Y.

(2021) ,Comprehensive proteomic analysis revealed a large number of newly identified proteins in thesmall extracellular vesicles of milk from late-stage lactating cows, Animals 11 2506
[319]

Shimozawa N., Takashima S., Kawai H., Kubota K., Sasai H., Orii K., Ogawa M., Ohnishi H.

(2021) ,Advanced diagnostic system and introduction of newborn screening of adrenoleukodystrophy andperoxisomal disorders in Japan, International Journal of Neonatal Screening 7 58
[320]

Takashima S., Takemoto S., Toyoshi K., Ohba A., Shimozawa N. (2021) ,Zebrafish model of human

Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene
expression changes, Molecular Genetics and Metabolism 133 307-323[321]

Kubota K., Kawai H., Takashima S., Shimohata T., Otsuki M., Ohnishi H., Shimozawa N.

(2021) ,Clinical evaluation of childhood cerebral adrenoleukodystrophy with balint's symptoms, Brain andDevelopment 43 396-401[322]

Okamoto H., Muraki I., Okada H., Tomita H., Suzuki K., Takada C., Wakayama Y., Kuroda A.,

Fukuda H., Kawasaki Y., Nishio A., Matsuo M., Tamaoki Y., Inagawa R., Takashima S., Taniguchi T.,
Suzuki A., Suzuki K., Miyazaki N., Kakino Y., Yasuda R., Fukuta T., Kitagawa Y., Miyake T., Doi T.,
Yoshida T., Yoshida S., Ogura S. (2021) ,Recombinant Antithrombin Attenuates Acute Respiratory
Distress Syndrome in Experimental Endotoxemia, American Journal of Pathology 191 1526-1536㸦㸧௧࿴  ᖺᗘእ㒊㈨㔠㈉⊩ᐇ⦼

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‫ڰ‬ຌඔྍ

$*‫ڰ‬ຌඔྍ

$*‫ڰ‬ຌඔྍ

ೖຌָढ़৾‫ڷ‬ճՌ‫ݜ‬ඇ ऑघ‫ڂݜ‬$*‫ڰ‬ຌඔྍ

ޮӻࡔ஄๑ਕ Ҷ੟ࡔ஄  Ҷ੟‫ঁڂݜ‬੔

$*

ঘࢃദ೯

‫خ‬൭‫ ڂݜ‬%࢐੓ౖৗʀ‫ף‬૫ʀ‫ץ‬ਭଳ੓Νଡ໚੏‫ͤޜ‬Ζ 6723 εητϞ͹
਒Կଡ༹੓

$*

ௗԮཤ

‫خ‬൭‫ ڂݜ‬$ৱ඾νϱϏέ࣯༟པ͹ࢹ࣯େःրવϘϕοχ͹ຌ࣯దཀྵմͳַ
৿దԢ༽Ͷ‫ͤؖ‬Ζ‫خ‬൭‫ڂݜ‬ʤେනʥ$*৕ϴ‫يݬ‬௪ಢཱིߨ੕๑ਕ‫࠸ڧ؂‬ਫ਼ฯસ‫ߑؽ‬ʀ‫ڂݜڧ؂‬૱߻ਬ਒ඇ৷ྲྀద֐པᄣ೗ྪ͹๹ঈ੕ࡨ݀ఈϕϫιη͹ͪΌ͹ଲࡨٗढ़͹
߶ౕԿ

$*

ᕈ໼‫ݲ‬

Ռ‫ݜ‬ඇʀ‫خ‬൭‫& ڂݜ‬Πϧ΢ήϜͳϜϱήʖηΝϠυϩͶͪ͢৷ྲྀద֐པᄣ೗ྪࠞઊ
͹ͪΌ͹ඈೝϭέοϱ֋൅ऑྫ࿪̑೧ౕ࿊೸‫ڂݜ‬ήϩʖϕ‫ܙ‬੔ࢩԋࣆ‫ۂ‬ʤຌָʥ
ྫ࿪̑೧ౕ࿊߻೸ָ
‫ڂݜ‬Ռऑघ‫گ‬ҽү੔ࣆ‫ۂ‬ʤຌָʥ

ώϧިࡸॄ஄Ν༽͏ͪ՘঄͹෾ࢮ੓͹Ҫఽմੵঘ೶൅ୣΝۨಊͤΖΠϩάωϱϟοϩԿ‫࣯خ‬͹ಋఈʀ‫ؽ‬೵մੵ



ౌ࿧൬ߺ

ࢱ໌

‫ڂݜ‬झ໪͵ʹ‫ڂݜ‬՟ୌ໌

$*

઴ీఅय़

‫خ‬൭‫ ڂݜ‬%ίϠΩ΢ϱण༲ରΝඬదͳͪ͢‫ݚ‬͹ൿේ 7 ࡋ๖ϨϱϏञͶଲͤ
Ζַ৿ద࣑ྏ๑͹֋൅$*‫ٸ‬࿮৽‫ޙ‬‫خ‬൭‫ ڂݜ‬%ΰόϞฦॄϜΤηͶΓΖ‫ݚ‬͹Ҫఽ੓࣮‫ݬͳ׳‬ҾҪఽࢢʀଡ‫ܗ‬͹ҾՎ‫ܐؖ‬͹ࣰ‫ݩ‬దৄ໎$*‫ٸ‬࿮৽‫ޙ‬ேકద‫ڂݜ‬ʤ๘լʥௗ࠱ 51$ εʖίϱηͶΓΖ &U\SWLFH[RQ ͹୵ࡩ

$*

Ԯీ࠾Յ

޲ਫ਼࿓ಉՌָ‫ึڂݜ‬ঁۜʀৱ඾͹҈સ֮ฯਬ਒‫ۂࣆڂݜ‬৿‫و‬घ๑ͶΓΖৱ௙೓Ͷ͕͜ΖΩϱϒϫώένʖԜઝয়‫ڱ‬͹௒ࠬͶ‫ͤؖ‬Ζ‫ڂݜ‬

$*

Ԯీ࠾Յ

ޮӻࡔ஄๑ਕࢀౣք
Ӥ‫ى‬೨ࡔ஄

ৱ஦ಡ‫ݬ‬Ҿۗ &DPS\OREDFWHUMHMXQL ͹‫ٵ‬ເͶ‫ؖ‬ΚΖʰη΢ρ
οʱ͹ಋఈ

$*

Ԯీ࠾Յ

Ҳൢࡔ஄๑ਕ‫ظ‬Ӫճܴ೓Ͷ͕͜Ζਫ਼͘ͱ͏Ζ͗ക཈Ͳ͘͵͏Ωϱϒϫώένʖ͹‫ݗ‬ड़๏๑͹ཱི֮

$*

ࢦਭ଻෤

ேકద‫ ڂݜ‬๘լ౛ເಊ෼͹ಝ੓ΝҫྏԢ༽ͤΖͪΌ͹ਕ޽౛ເ༢൅Ͷ‫ͤؖ‬Ζ‫ݜ‬
‫ڂ‬

$*

ࢦਭ଻෤

‫خ‬൭‫ ڂݜ‬%஦਽ਈ‫ܨ‬ͶΓΖ୉ௐӣಊ੏‫ͳߑؽޜ‬ഋสҡ৙Ͷ೟ΌΔΗΖ੓ࠫ͹ϟΩωθϞմ໎

$*

ࢃ಼߅ਫ਼

ऑघ‫ڂݜ‬‫఺ؠ‬ҢΝ૏֒ͤΖϟοϩέΥϩιοϱ͹ࡠ༽‫ؽ‬঄͹մ໎$*஦ઔ‫ܡ‬ղ

ࢀౣքӤ‫ى‬೨ࡔ஄‫ݜ‬‫ঁڂ‬੔ਫ਼ϭέοϱ ֋൅Ν໪ࢨͪ͢‫ډ‬αϫψΤ΢ϩηҪఽࢢ૤ࡠ‫ܧ‬͹֮
ཱི

$*

஦ઔ‫ܡ‬ղ

ґ౽‫ى‬೨ࡔ஄‫ঁڂݜ‬੔΢όεεͶ͕͜Ζ಴αϫψΤ΢ϩηླྀߨࣰସ௒ࠬ

$*஦ઔ‫ܡ‬ղ

‫ز‬෠‫ݟ‬ʀҗ୙ࣆ‫ۂ‬‫ز‬෠‫ݟ‬Ͷ͕͜Ζܴఽઝ੓‫ـ‬؇ࢩԎ͹ਃ७௒ࠬ

$*

ෳ࢞ऴਕ

‫خ‬൭‫ ڂݜ‬%

$*

ෳ࢞ऴਕ

޲ਫ਼࿓ಉߨ੕ਬ਒௒
ࠬࣆ‫ۂ‬ඇึঁۜʤ৿
‫ڷ‬ʀ࠸‫״ڷ‬ઝ঳‫;ٶ‬༩๹ંझ੕ࡨਬ਒‫ݜ‬‫ۂࣆڂ‬ʥ

ϖϩϘηΤ΢ϩηͶΓΖ஗ࢰ੓೶Ԏ͹൅‫ߑؽݳ‬մ໎͕Γ;༩๹๑ཱི֮Ͷ޴ͪ͜‫ેخ‬ద‫ڂݜ‬

$*

ґ౽௜ਕ

‫خ‬൭‫ ڂݜ‬%

$*

ґ౽௜ਕ

ࠅࡏ‫ڠ‬ಋ‫ڂݜ‬Յଐ‫خ‬ۜ ࠅࡏ‫ڠ‬ಋ‫کڂݜ‬
Կ %

$*

߶ౣ߃߄

‫خ‬൭‫ ڂݜ‬%φΫλϕϧθϜɼϋΨηϛϧ͹ઞ෮͖Δ͹‫׈‬੓ԿΝ࢚Ζ෾ࢢϟΩωθϞ͹մ໎

$*

ࢃຌ࣑ٝ

‫خ‬൭‫& ڂݜ‬झ಼ψοϣϧϩώϨΦʖεϥϱΝ༽͏ͪ৪෼ϕϫϠʖνʖ͹਒Կదଈ໚͹մ໎

$*

༆ੋ঺ࢢ

‫خ‬൭‫& ڂݜ‬ߜண͹कགྷ͵‫ؽ‬೵੓Ν࢚ΖτΠϩϑζϱ͹ߑଆմ໎

$*

༆ੋ঺ࢢ

‫ڠ‬ಋ‫ڂݜ‬᷄޽৖‫ݬ‬ྋ༽๚ࢊ඾෯ࢊ෼͹༙ް‫༽׈‬Ͷ‫ͤؖ‬Ζ‫ڂݜ‬

$*

༆ੋ঺ࢢ

‫ڠ‬ಋ‫ ڂݜ‬Πϩϕη༂඾޽‫ה ۂ‬ϓϧϚό΢χ͹ϕϪώ΢ΨτΡέη‫ڂݜ‬

$*

༆ੋ঺ࢢ

‫ڠ‬ಋ‫ڂݜ‬Φϱη᷄ਫ਼ཀྵ‫׈‬੓ళષ෼͹ਫ਼෼༙‫ؽ‬Կָద‫ڂݜ‬

ೖ৿๚ຸ

ௗྒྷγ΢

Ѭ‫؟‬ಊ෼༟པ‫״‬ઝ঳੏‫ޜ‬͹ͪΌ͹ɼ‫״‬ઝ঳൅ਫ਼য়‫ڱ‬ɼ‫ݬ‬Ҿබ‫ݬ‬ର‫;ٶ‬ॕकಊ෼͹մੵͶ‫͚Ͱخ‬Ϩηέ඲Ճͳ‫ܔ‬൅Ͷ‫ͤؖ‬Ζ‫ڂݜ‬ʤ෾୴ʥ߶‫ౕ״‬͹‫״‬ઝࡋ๖‫ݗ‬ड़‫ܧ‬Ν༽͏ͪ‫ݚڲ‬බΤ΢ϩη͹຦঩‫״‬ઝಊସ͹մੵ࠹઎୼΢ϟʖζϱήٗढ़Ν‫ݚڲͪ͢༽׈‬බΤ΢ϩη໼֐‫ה‬͹຦঩‫״‬ઝ‫ؽ‬঄͹մ໎

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ౌ࿧൬ߺ

ࢱ໌

‫ڂݜ‬झ໪͵ʹ‫ڂݜ‬՟ୌ໌

$*

છҬర෋

‫خ‬൭‫ ڂݜ‬$ΰόϞմੵͳ਼ཀྵմੵΝ༽͏ͪಊ෼͹ऀճਫ਼‫׈‬ͶΓΖ༂ࡐଳ੓ۗ͹‫ڧ؂‬Ԝઝ͹մੵ$*ন‫ݬ‬ཇҲ

‫خ‬൭‫& ڂݜ‬ελՌ৪෼͹ࠠ৪ͶΓΖ৪෼ਫ਼ௗଇ਒‫ߑؽ‬մ໎‫و৿;ٶ‬৪෼੔ௗրવ๑΃͹Ԣ༽$*ন‫ݬ‬ཇҲޮࡔ Ӟ৏ৱ඾ʀৱ
ชԿ৾‫ࡔڷ‬஄ελՌύʖϔ  ࣏େः੔෾͹ϟνϚϫʖϞմੵ‫ؽ߶;ٶ‬೵ԿͶ‫ͤؖ‬Ζ‫ڂݜ‬$*ন‫ݬ‬ཇҲ

஦෨ుྙʤ‫ה‬ʥۗࠞۗ‫༽׈‬ͶΓΖ೸‫ڷ৾ۂ‬౵Ν௪ͣͪஏҮ߫‫ࡨݛ‬͹‫ݗ‬౾$*ք࿟‫ݬ‬হ࿢

$*ք࿟‫ݬ‬হ࿢

$*

ੜਭগช

‫خ‬൭‫ ڂݜ‬%༙༽ࠞ‫ॴۗࡋݏ‬ཀྵͶΓΕ৪෼Ͷ༢಍͠ΗΖ੪‫ޅ‬බۗഋঈ‫ݳ‬ে͹෾ࢢ‫ߑؽ‬մ໎

$*

஦ଞߔฑ

‫خ‬൭‫& ڂݜ‬੶་͹ϟνϱ൅߮ͶΓΖ੶་ଁ਒յफʷ&2 ϓϨʖਭો‫ݱڇڛ‬૓ड़͹Ն೵੓͹‫ৄݗ‬

$*

ஶౣ߃༦

‫خ‬൭‫ ڂݜ‬%ΦέλλʖϞ಼෾ࢢ͹‫ڏ‬ಊͳ‫ఽډ‬ઝ੓ϨϱϏञ൅঳ͳ͹‫ؖ‬࿊մ
໎

$*

୉੤݊෋

‫خ‬൭‫ ڂݜ‬%$*ೖ‫ת‬෤༡ྫ࿪  ೧ౕ ޮӻࡔ஄๑ਕ ґ౽‫ى‬೨ࡔ஄ ‫ঁڂݜ‬੔ࣆ‫ۂ‬ౖৗͶ͕͜Ζ࢐Կؒ‫ݫ‬ൕԢ͹௜ંద੏‫ޜ‬ͺՆ೵͖ʃʘͨ͹Ն೵੓ͳ‫ݸ‬ֆΝ୵Ζʘ߇࢐Կ෼࣯Νཤ༽ͪ͢Τεର֐ण੠ཝਫ਼ࢊٗढ़͹߶ౕԿͳͨΗΝԢ༽ͪ͢৿‫ و‬238,9)(7 ͶΓΖࢢ‫ډ‬ਫ਼ࢊεητϞ͹֋൅
ʤᶚʥ

'0

ฑౣҲٍ

'0

ฑౣҲٍ

ޮӻࡔ஄๑ਕ ෤ీՌָ৾‫ࡔڷ‬஄ ҫָ‫ঁڂݜܧ‬੔߶‫׈‬੓ϝφαϱχϨΠ‫࠱ٷݼ‬෵߻ର , ૏֒ࡐͲ͍ΖϘνεϱ͹
ඬద෾ࢢ͹ಋఈ

'0

ࢃຌ༲ਜ਼

‫خ‬൭‫ ڂݜ‬$ೖຌָढ़৾‫ڷ‬ճ  Ռָ‫ڂݜ‬ඇঁ੔ࣆ‫ۂ‬‫خ‬൭‫& ڂݜ‬ช෨Ռָ঴  ࠅࡏ‫ڠ‬ಋ‫ڂݜ‬Յଐ‫ࠅ ۜخ‬ࡏ‫ڠ‬ಋ‫کڂݜ‬Կ %ޮӻࡔ஄๑ਕঘྜྷࡔ஄ ‫ঁڂݜ‬੔౨‫ښ‬೸‫ۂ‬୉ָਫ਼෼ࣁ
‫ݱ‬ΰόϞմੵιϱνʖ  ೧ౕʤ઴‫غ‬ʥਫ਼෼ࣁ‫ݱ‬ΰόϞմੵ‫ڠ఼ڎ‬ಋཤ༽ʀ‫ڠ‬ಋ‫ڂݜ‬՟ୌ ೧  ݆   ೧ ݆ླྀҮ‫ݏ‬Ռָ‫ڂݜ‬ιϱνʖ  ྫ࿪̑೧ౕ ‫ڠ‬ಋ‫ูޮڂݜ‬ࣆ‫ ۂ‬Ҳൢ‫ڂݜ‬՟ୌ*ླྀҮ‫ݏ‬Ռָ‫ڂݜ‬ιϱνʖ  ྫ࿪̑೧ౕ ‫ڠ‬ಋ‫ูޮڂݜ‬ࣆ‫ ۂ‬Ҳൢ‫ڂݜ‬՟ୌ*5<ೖ‫ܛ‬໼҃ߵీ஦‫ܔ‬ղ ຌ‫ܜڰ‬Ҳ ‫ࢃܢ‬
߀್

5<

ฤ‫಺ ۇ‬ʓ ‫ز‬෠‫ڂݜྜྷਁݟ‬ॶʥ5<ঘౣҲٍ ‫ز‬෠‫ݟ‬೸‫ٗۂ‬ढ़
ιϱνʖ

5<

ཧ෍ਫ਼

‫خ‬൭‫ ڂݜ‬$

5<

੶ࠉ଻

‫خ‬൭‫& ڂݜ‬݄؇্֒ϜϩοϜʖΩʖ͹ʰͨ͹৖ʱಋ࣎෾ੵ๑͹֋൅ͳ౸೚
බ߻ญ঳༩‫΃ݡ‬͹ఴ֋౸೚බ߻ญ঳૥‫غ‬ϜʖΩʖϕϫϪωϱ͹බସਫ਼Կָదқٝ͹մ໎ೖһ൬‫ڠ‬ಋ‫ڂݜ‬ϓΫόφΤ༟པ߶‫׈‬੓ϝφαϱχϨΠ૏֒෼࣯͹ञ ಝҡదଁ৫ʀ఺Ң૏֒ϟΩωθϞ͹մ໎౏৏ࠅαϝϣωτ΢ͶະԈͤΖαϨηοϱଳ੓ۗ͹ອ੓Կͳͨ
͹‫ؽ‬঄մ໎

೸ߠஏबว‫ڧ؂‬Ͷ͕͜Ζ৪෼බ‫ݬ‬੓ཝۗྪ͹෾ාಝ੓͹մ໎ͳබ֒Ϩηέ඲Ճ

ϐόΫࠞ‫ה‬ෙ‫ټ‬අ֒Ͷ‫ؖ‬༫ͤΖ໨ࡒෙ‫ۗټ‬͹ࣰସմ໎ʰ‫ܙݽ‬കஏߠࡁകͶଲԢͪ͢බ֒ம๹ঈଲࡨٗढ़͹ཱི֮ʱʛφϜφҦ஼঳য়ͳཝۗྪ͹‫ؖ‬࿊੓඲Ճʛ
ਫ਼෼‫׈‬੓୺߶ౕ৞ਭॴཀྵͶ͕͜Ζ༂ࡐଳ੓Ҫఽࢢ͹ఽ೽‫ͳߑؽ‬ͨ͹ཊ੏৞Կ૩಼Ͷ͕͜Ζ༂ࡐଳ੓͕ۗΓ;༂ࡐଳ੓Ҫఽࢢ͹ভௗͳ૤ࡠӣ఺ড়݇ͶΓΖཊ੏

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ࢱ໌

‫ڂݜ‬झ໪͵ʹ

+$

ྵ໨݊Ҳ

Ռָٗढ़৾‫ߑؽڷ‬&5(67߶੠ౕ  ෾ࢢ؏ࡱͶΓΖΦέλλʖϞຜಊସ͹մ໎

+$

ྵ໨݊Ҳ

ேકద‫ڂݜ‬ʤ๘լʥ‫࣯ܙ‬ຜ಼૜͹ඏঘχϟ΢ϱಊସʁ௔մ଀‫ݨ‬ඏ‫ں‬๑͕Γ;  ෾ࢢ΢ϟʖζϱήͶΓΖմ໎

+$

҈౽߄भ

‫خ‬൭‫ ڂݜ‬$౸࠱ϕϫʖϔΝ༽͏ͪࡋ๖ຜඏঘ྘Ү͹ߑଆͳ‫ؽ‬೵͹੠մ+$ਁ֠‫ݓ‬Ҳ

‫خ‬൭‫ ڂݜ‬%ਕ޽ຜͳψό‫ؔۯ‬Ν༽͏ͱࡋ๖ຜ͹ඏঘ‫ڧ؂‬Ν࠸‫͢ݳ‬ຜνϱϏέ࣯෾ࢢ෼੓Ν‫ܯ‬଎ͤΖ

+$

ྵ໨݊Ҳ

‫خ‬൭‫ ڂݜ‬%߶੠ౕ  ෾ࢢ؏ࡱͶΓΖ౸ࢹ࣯͹‫ؽ‬೵੓έϧηνʖ‫ܙ‬੔‫ߑؽ‬͹մ໎ͳ֌૜ߑଆ͹‫ৄݗ‬

+$

໨௫߃ඛ

‫خ‬൭‫ ڂݜ‬%౸࠱͹෾‫ܙز‬੔ͶΓΖ͗ΞʀΠϩςύ΢Ϝʖබ͹ѳ੓ԿϟΩω
θϞ

/6

ਤծ੘‫ٳ‬

೸ྜྷਭࢊ঴җ୙ϕϫζΥέφ‫ࢊࠅڂݜ‬೸ࢊ෼஦͹͖;ಡ‫;͖;ٶ‬ಡྪԓର͹ಊସմ໎ด;ͶԜઝ͹๹ࢯ‫;ٶ‬ఁ‫ݰ‬Ͷ‫ͤؖ‬Ζ‫ڂݜ‬'1$ ηφϨρϕͶΓΖശྪ੼͖;බۗ͹φϨατιϱಡો‫ܗ‬؈ҝ൓ఈ๑͹֋൅

/6

Ծᖔ৵ߨ

‫خ‬൭‫ ڂݜ‬%ϜϩοΨϝρέηմੵͶͱ୉೶‫ܗ‬൅঳༩଎๑Ν֋൅͢෯ਝപ࣯
ζηφϫϓΡʖΝࠂෲͤΖ

/6

Ծᖔ৵ߨ

ேકద‫ڂݜ‬ʤ๘լʥ֨୉৿ਫ਼ࣉηέϨʖωϱήਏྏࢩԋϠυϩཱི֮ͶΓΖࣰભదࠅ಼ೋබࠂෲ‫ڂݜ‬

/6

Ծᖔ৵ߨ

/6

Ծᖔ৵ߨ

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ຉҬ༙‫س‬‫׈ڂݜ‬ಊηνʖφࢩԋ౛ເ༹મ୔దηϕϧ΢εϱή௒ઇͶΓΖఁԻεϥρένϱϏέ
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ஶౣ߃༦ʤେ
නʥ߶ౣໞ༦
ʤ෾୴ʥ୉‫ݓڰ‬ଢ࿢
ʤେනʥ߶ౣ
ໞ༦ʤ෾୴ʥ

޲ਫ਼࿓ಉՌָ‫ڂݜ‬ඇึঁۜʤೋ࣑੓࣮‫ࠂ׳‬ෲ‫ۂࣆڂݜ‬ʥʤ෾୴ʥ
ೖຌҫྏ‫֋ڂݜ‬൅‫ߑؽ‬੔ү࣮‫ࠂ׳‬ෲ౵૱߻‫ݜ‬‫ۂࣆڂ‬ʤ෾୴‫ंڂݜ‬ʥ಼౽‫ى‬೨Ռָ৾‫ࡔڷ‬஄ʀ಼౽‫ى‬೨ঃ੓‫ڂݜ‬ंঁ੔ۜεʖεʖΠ΢ϙʖϩυΡϱήη‫ࣞה‬ճऀʀεʖεʖΠ΢ϙʖϩυΡϱήη‫ঁڂݜ‬੔ϕϫήϧϞ‫ڂݜ‬՟ୌ໌

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ࢤࣀ࣒◊✲ศ㔝ᩍဨࡢᩍ⫱◊✲άື➼ձ ᩍ⫱άື
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୺࣭๪ᣦᑟᩍဨ
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Kobayashi H, Kawaguchi K, Yamamoto S, Shimozawa N, So T, Imanaka T. Bone marrow transplantation
into Abcd1-deficient mice: Distribution of donor derived-cells and biological characterization of the brainof the recipient mice. J Inherit Metab Dis. 2021; 44(3): 718-727.
17. Kubota K, Kawai H, Takashima S, Shimohata T, Otsuki M, Ohnishi H, Shimozawa N. Clinical evaluationof childhood cerebral adrenoleukodystrophy with balint's symptoms. Brain Dev. 2021; 43(3): 396-401.
18. Takashima S, Takemoto S, Toyoshi K, Ohba A, Shimozawa N. Zebrafish model of human Zellweger
syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene
expression changes. Mol Genet Metab. 2021 May 8:S1096-7192(21)00703-4.
19. Koji Kato, Hiromasa Yabe, Nobuyuki Shimozawa, Souichi Adachi, Mineo Kurokawa, Yoshiko Hashii,
Atsushi Sato, Nao Yoshida, Makiko Kaga, Osamu Onodera, Shunichi Kato, Yoshiko Atsuta, and Tomohiro
Morio. Stem Cell Transplantation for Pediatric Patients with Adrenoleukodystrophy: A nationwide
retrospective analysis in Japan. Pediatric Transplantation. 2021 Oct 18;e14125.
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㸦࿴ᩥ⥲ㄝ㸧
1.

ᕝྜ⿱つࠊஂಖ⏣୍⏕ࠊୗ⃝ఙ⾜. 㧗ḟ⬻ᶵ⬟㞀ᐖ࡛Ⓨ⑕ࡋࡓᑠඣ኱⬻ᆺ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡢ
᪩ᮇデ᩿ࡢࡓࡵࡢ⮫ᗋᏛⓗ᳨ウ. ᑠඣࡢ⢭⚄࡜⚄⤒ 61 (1) 35-41, 2021 ᖺ 4 ᭶2.

ୗ⃝ఙ⾜. 㑇ఏ⏕໬Ꮫ ⮫ᗋ㑇ఏᑓ㛛་ࢸ࢟ࢫࢺ㸯 ⮫ᗋ㑇ఏᏛ⥲ㄽ デ᩿࡜἞⒪♫. ᮾி. 2021 ᖺ7᭶

3.

ୗ⃝ఙ⾜. ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢᅜෆᑟධ࡟ྥࡅ࡚ࡢ⌧≧࡜ㄢ㢟. ≉㞟 ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ࡜἞⒪ࡢ᭱๓⥺. 㑇ఏᏊ་Ꮫ 11 (3) 80-87, 2021 ᖺ 7 ᭶4.

㧗ᓥⱱ㞝ࠊୗ⃝ఙ⾜. ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓࡟࠾ࡅࡿ⬡㉁௦ㅰ࡜἞⒪. The Lipid ≉㞟 ࢜ࣝ࢞ࢿࣛ࡜⬡㉁ Ѹᇶ♏࡜⮫ᗋ࠿ࡽѸ 32 (2) 76-84, 2021 ᖺ 10 ᭶

5.

ୗ⃝ఙ⾜. ABCD1㸦㛵㐃⑌ᝈ㸸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮㸧 ᑠඣ⛉デ⒪ ≉㞟 ᑠඣ㑇ఏᏊ⑌ᝈ㎡඾ 84(11) 1511-1513, 2021 ᖺ 11 ᭶

6.

ୗ⃝ఙ⾜. ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ ⬻⚄⤒ෆ⛉デ᩿ࣁࣥࢻࣈࢵࢡ ୗ⏿஽Ⰻ⦅୰እ་Ꮫ♫. ᮾி.

2022 ᖺ 1 ᭶
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1.

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0.%ORPTXLVW&/%RZGHQ5/%UDQNRYLFV%%URZQ':%XUJHVV/:%XVKOH\.%XVPDQ0&DQR-/LUD-)&DUULOOR-'&KDQJ+-;&KHQ&-<&KHQ:&KLOYHUV0&KXO]H6&ROHPDQ--&XRPR&$:LOKHOPGH%HHU=6\EUHQGH+RRJ*&DVWLOOR-0XQHUD-''HO3RQWH(0'LHJXH]8ULEHRQGR-3LHWUR$'(GHO-+HUPDQQ9(OPHU:+(SVWHLQ/(VNDOHQ$(VSRVWR0&(YHUWV./)HUQDQGH]-3DYÕD63GD6LOYD*))RURXG1$)RXULH*)UDQGVHQ5-1)UHHPDQ6)UHLWDJ0)UHQNHO2)XOOHU..*DJNDHYD7*DUGLQHU'0*OHQQ$(*ROG6(*RUGRQ75*UHJRU\1)*U\]HQKRXW0*XDUUR-*XJLQR%.*XWLHUUH]6+DPPRQG-.RVDFN.(+DUULV/-+RPD0+RQJ&-)+RUQRN/+XDQJ--:,ONLW0-DFREV$-DFREV.-LDQJ&GHO0DU-LPHQH]-*DVFR0.DQJ6.DVVRQ07.D]DQ..HQQHOO-&.LP+-6&RUE\.LVWOHU+.XOGDX*$.XOLN7.XU]DL
2/DUDED,/DXUHQFH0+/HH7/HH<-:/HH<-+/HVOLH-)/LHZ(&</RIWRQ/:/RJULHFR$)/RSH]-%HUJHV06/XTXH$*/\V¡H(0D/--0DUUD5(0DUWLQ)10D\650F&RUPLFN630F*HH&0HLV-)0LJKHOL40RKDPHG1RU10,0RQRG00RUHWWL$0RVWHUW'0XOH*0XQDXW)0XQNYROG*31LFKROVRQ31XFFL02¶'RQQHOO.3DVTXDOL03IHQQLQJ/+3ULJLWDQR$3URFWRU5+5DQTXH65HKQHU6$5HS05RGUÕJXH]-$OYDUDGR*5RVH/-5RWK0*5XL]5ROGDQ&6DOHK$$6DOOHK%6DQJ+6FDQGLDQL006FDXIODLUH-6FKPDOH'*6KRUW'3*
6LVLF$6PLWK-$6P\WK&:6RQ+6SDKU(6WDMLFK-(6WHHQNDPS(6WHLQEHUJ&6XEUDPDQLDP
56XJD+6XPPHUHOO%$6XVFD$6ZHWW&/7RRPDMLDQ&7RUUHV-&UX]7-7RUWRUDQR$08UEDQ
09DLOODQFRXUW /-9DOODG *( YDQ GHU /HH7$-9DQGHUSRRO ' YDQ 'LHSHQLQJHQ$'9DXJKDQ009HQWHU(9HUPHXOHQ09HUZHLM3(9LOMRHQ$:DDOZLMN&:DOODFH(&:DOWKHU*:DQJ-
:DUG7-:LFNHV%/:LHGHUKROG13:LQJILHOG0-:RRG$.0;X--5<DQJ;-%<OL-0DWWLOD
7<XQ6-+=DNDULD/=KDQJ+=KDQJ1=KDQJ6;=KDQJ;  3K\ORJHQRPLFDQDO\VLVRID-NE -JHQH GDWDVHW UHVROYHV D PRQRSK\OHWLF )XVDULXP WKDW LQFOXGHV WKH IXVDULXP VRODQL VSHFLHVFRPSOH[3K\WRSDWKRORJ\-㸺Ꮫ఍Ⓨ⾲㸼㸦ᅜ㝿㸧࡞ࡋ㸦ᅜෆ㸧 613 ࢱ࢖ࣆࣥࢢ࡟ࡼࡿࣉࣟࢡࣟࣛࢬ⪏ᛶࡤ࠿ⱑ⑓⳦ࡢ᳨ฟ ⸨᫴୍ ᳃㇂┿⣖Ꮚ 㘊⚽ᩯ ᥀Ṋᚿ
㡲㈡ᬕஂ ௧࿴ ᖺᗘ᪥ᮏ᳜≀⑓⌮Ꮫ఍ᮾ໭㒊఍  ᖺ  ᭶ )XVDULXP IXMLNXURL 」ྜ✀ࡢ㔜」ឤᰁࡣࡤ࠿ⱑ⑓ࡢⓎ⑓㐜ᘏࢆᘬࡁ㉳ࡇࡍ ఀ㈡ඃᐇ 㡲㈡ᬕஂ
⸨ ᫴୍ ௧࿴ ᖺᗘ᪥ᮏ᳜≀⑓⌮Ꮫ఍ᮾ໭㒊఍  ᖺ  ᭶ ㏆ᖺศ㞳ࡉࢀࡓ )XVDULXP IXMLNXURL ࢖ࢿࡤ࠿ⱑ⑓⳦ ࡢ࢖ࣉࢥࢼࢰ࣮ࣝ࡟ᑐࡍࡿឤཷᛶ࡜ྠ๣ࡢ㜵㝖ຠᯝࡢ☜ㄆ ❿▼⚽᫂బᡞ⩧ኴ㡲㈡ᬕஂ ௧࿴  ᖺᗘ᪥ᮏ᳜≀⑓⌮Ꮫ఍኱఍  ᖺ  ᭶ )XVDULXP IXMLNXURL ࡟࠾ࡅࡿࣉࣟࢡࣟࣛࢬ⪏ᛶᰴ࠿ࡽឤཷᛶᰴ࡬ࡢ &<3% ᑟධ࡟ࡼࡿࣉࣟࢡࣟࣛ
ࢬ⪏ᛶ௜୚ 㯪ⰾ㟹㩚፣㞷ᆏཎඃ㔛ᯇᮏᙬⰋ⸨᫴୍ΎỈᑗᩥᬒᒣᖾ஧㡲㈡ᬕஂ ௧࿴ ᖺᗘ㗌ᮏ᳜≀⑓⌮Ꮫ఍⤎఍  ᖺ  ᭶ ⴥ㠃ᩓᕸ࡛ࢺ࣐ࢺ㟷ᯤ⑓ࢆᢚไࡍࡿ᳜≀ෆ⏕ %DFLOOXV ᒓ⳦ࡢ᥈⣴ +XL=KHQ)X0DOHN0DULDQᴮ
ᮏᣅኸ᪥ᜨ㔝⥤㤶ఀዉ⚽ᑗ㡲㈡ᬕஂΎỈᑗᩥ ௧࿴  ᖺᗘ᪥ᮏ᳜≀⑓⌮Ꮫ఍኱఍  ᖺ ᭶ ᰾㓟ࢡ࣐ࣟࢺࢢࣛࣇ࢕࣮࡟ࡼࡿ࣒ࢠ㢮㉥࠿ࡧ⑓⳦ࡢ⳦✀࡜ࢺࣜࢥࢸࢭࣥẘ⣲ࢱ࢖ࣉุᐃἲࡢ㛤Ⓨ
㡲㈡ᬕஂᯘᑗ኱຾཭⨾⮻஭⥤ᏊΎỈᑗᩥᬒᒣᖾ஧ ➨ ᅇ᪥ᮏ࣐࢖ࢥࢺ࢟ࢩࣥᏛ఍Ꮫ
⾡ㅮ₇఍  ᖺ  ᭶ 㧗ᓥ ⱱ㞝㇏ྜྷ ె௦Ꮚ኱ሙ ளᕼᏊୗ⃝ ఙ⾜ࠕࢮࣈࣛࣇ࢕ࢵࢩࣗࣔࢹࣝࢆ౑ࡗࡓ =HOOZHJHUV\QGURPH ⑓ែⓎ⑕ᶵᵓࡢ᥈⣴ࠖ ➨㸴㸰ᅇ᪥ᮏඛኳ௦ㅰ␗ᖖᏛ఍ Ꮫ⾡㞟఍  ᖺ  ᭶ 㧗ᓥ ⱱ㞝㇏ྜྷ ె௦Ꮚ኱ሙ ளᕼᏊୗ⃝ ఙ⾜ࠕࢮࣈࣛࣇ࢕ࢵࢩࣗ =HOOZHJHUV\QGURPH ࣔࢹࣝ࡟࠾ࡅࡿ㑇ఏᏊⓎ⌧ኚືゎᯒࠖ➨㸴㸰ᅇ᪥ᮏඛኳ௦ㅰ␗ᖖᏛ఍ Ꮫ⾡㞟఍ ᖺ  ᭶ 㧗ᓥ ⱱ㞝 ㇏ྜྷ ె௦Ꮚ ኱ሙ ளᕼᏊ ୗ⃝ ఙ⾜ ࠕ/&06 ࢆ⏝࠸ࡓ୙㣬࿴⬡⫫㓟ࡢ஧㔜⤖ྜ఩⨨ࡢྠᐃࠖ➨㸴㸮ᅇ᪥ᮏἜ໬Ꮫ఍ᖺ఍ ᖺ  ᭶㸦㸧⿵ຓ㔠㛵㐃᥇ᢥ≧ἣୗ⃝ఙ⾜ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝ᇶ┙◊✲ % 㸦◊✲௦⾲⪅㸧ࠕ࣐ࣝࢳ࣑࢜ࢵࢡࢫゎᯒ࡟࡚኱⬻ᆺⓎ⑕ண ἲࢆ㛤Ⓨࡋ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࢆඞ᭹ࡍࡿࠖ㸸 ༓෇ᩥ㒊⛉Ꮫ┬⛉Ꮫ◊✲㈝ᣮᡓⓗⴌⱆ㸦◊✲௦⾲⪅㸧ࠕᣑ኱᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢデ⒪ᨭ᥼ࣔࢹࣝ☜❧࡟ࡼࡿᐇ㊶ⓗᅜෆ㞴⑓ඞ᭹◊✲ࠖ㸸 ༓෇ཌ⏕ປാ⛉Ꮫ◊✲㈝⿵ຓ㔠㸦㞴἞ᛶ⑌ᝈඞ᭹◊✲஦ᴗ㸧㸦ศᢸ◊✲⪅㸧ࠕࣛ࢖ࢯࢰ࣮࣒⑓ࠊ࣌ࣝ࢜
࢟ࢩࢯ࣮࣒⑓㸦๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕̿ࢆྵࡴ㸧࡟࠾ࡅࡿⰋ㉁࠿ࡘ㐺ษ࡞་⒪ࡢᐇ⌧࡟ྥࡅࡓయ
ไࡢᵓ⠏࡜ࡑࡢᐇ⿦࡟㛵ࡍࡿ◊✲ࠖ㸸 ༓෇
᪥ᮏ་⒪◊✲㛤Ⓨᶵᵓ ᡂ⫱⑌ᝈඞ᭹➼⥲ྜ◊✲஦ᴗ㸦ศᢸ◊✲⪅㸧ࠕ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢᑐ㇟ᣑ඘ࡢࡓࡵࡢ⑌ᝈ㑅ᐃᇶ‽ࡢ☜❧ࠖ㸸 ༓෇

㡲㈡ᬕஂ
㎰ᯘỈ⏘┬ጤクࣉࣟࢪ࢙ࢡࢺ◊✲ ᅜ⏘㎰⏘≀୰ࡢ࠿ࡧẘཬࡧ࠿ࡧẘ㢮⦕యࡢືែゎ᫂୪ࡧ࡟ởᰁࡢ㜵Ṇཬࡧపῶ࡟㛵ࡍࡿ◊✲  ㄢ㢟㈐௵⪅ ࠕ'1$ ࢫࢺࣜࢵࣉ࡟ࡼࡿ㯏㢮㉥࠿ࡧ⑓⳦ࡢࢺࣜ
ࢥࢸࢭࣥẘ⣲ᆺ⡆ุ᫆ᐃἲࡢ㛤Ⓨࠖ  ༓෇㧗ᓥⱱ㞝௧࿴ඖᖺ̺ ᖺᗘ ⛉Ꮫ◊✲㈝⿵ຓ㔠ᇶ┙◊✲㸦&㸧 ◊✲௦⾲⪅ ࠕ⑌ᝈࣔࢹࣝࢆ⏝࠸ࡓ࣌ࣝ࢜࢟
ࢩࢯ࣮࣒ᙧᡂ␗ᖖ⑕Ⓨ⑕ᅉᏊࡢ≉ᐃࠖ㸦㸧᪂⪺ሗ㐨➼࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ⒪యไࢆ☜❧ࡍࡿࡲ࡛ࡢ◊✲άື ୗ⃝ఙ⾜࣒ࢥከ⢾ࣉࣟࢧ࢖ࢺྲྀᮦ࣏࣮ࣞࢺ
KWWSVPSVSURMFUMSUHSRUWUHSRUWBSKS
௨ୗ࡟ᥖ㍕ࠋ

࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ⒪యไࢆ☜❧ࡍࡿࡲ࡛ࡢ◊✲άືᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ࢤࣀ࣒◊✲ศ㔝ᩍᤵ

ୗ⃝ఙ⾜

ඛ⏕

࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡣ  ᖺ௦௨㝆࡟ཎᅉࡀ᫂ࡽ࠿࡟࡞ࡗࡓẚ㍑ⓗࠊ◊✲ࡢṔྐࡀὸ࠸⑌ᝈ࡛࠶ࡿࠋ
ᒱ㜧኱Ꮫࡢ◊✲ࢢ࣮ࣝࣉࡣୡ⏺࡟ඛ㥑ࡅ࡚ࡇࡢ⑌ᝈࡢ⑓ែゎ᫂ࢆ㐍ࡵ࡚ࡁࡓࡇ࡜࡛▱ࡽࢀ࡚࠸ࡿࠋྠࢢ
࣮ࣝࣉࡢ◊✲࡟ࡼࡾ⑌ᝈࡀㄆ▱ࡉࢀࠊ ᖺ࠿ࡽࡣ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡶጞࡲࡗࡓࠋ
ྠ኱Ꮫࡢୗ⃝ఙ⾜ඛ⏕࡟ୡ⏺ึࡢ⑓ᅉ㑇ఏᏊⓎぢ࠿ࡽデ⒪యไࡢ☜❧ࡲ࡛ࡢάືࢆ⪺ࡃࠋୗ⃝ఙ⾜ඛ⏕㸦᧜ᙳ㸸㉺㔝㱟ᙪࠊ௨ୗྠࡌ㸧ୗ⃝ඛ⏕ࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ◊✲࡟╔ᡭࡋࡓࡢࡣ࠾ࡼࡑ  ᖺ๓ࡢ  ᖺࡢࡇ࡜ࡔࡗࡓࠋᒱ㜧኱Ꮫᑠඣ⛉࡟࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀḞᦆࡍࡿ =HOOZHJHU ⑕ೃ⩌㸦⬻⫢⭈⑕ೃ⩌ࠊࢶ࢙࣮ࣝ࣋࢞⑕ೃ⩌㸧ࡢ᪂⏕ඣࡀධ㝔ࡋࡓࡢࡀࡁࡗ࠿ࡅ࡛࠶ࡿࠋ
ᙜ᫬ࡣ⑌ᝈ⮬యࡀ࠶ࡲࡾ▱ࡽࢀ࡚࠾ࡽࡎࠊᙜึデ᩿ࡀ௜࠿࡞࠿ࡗࡓࡀࠊࡇࢀࢆዎᶵ࡟ୗ⃝ඛ⏕ࡢඛ㍮
ࡢ㕥ᮌᗣஅඛ⏕ࡀ⮫ᗋ◊✲ࢆࢫࢱ࣮ࢺࡋࠊୗ⃝ඛ⏕ࡶඹ࡟◊✲࡟ྲྀࡾ⤌ࡴࡇ࡜࡟࡞ࡗࡓࠋ
ࠕᙜ᫬ࡢᒱ㜧኱Ꮫᑠඣ⛉ࡢᩍᤵ࡛࠶ࡗࡓᢡᒃᛅኵඛ⏕ࡀඛኳ௦ㅰ␗ᖖࢆ୺࡞◊✲ࢸ࣮࣐࡜ࡋ࡚࠾ࡾࠊ
ࡑࡢ୰࡛ࡶࣛ࢖ࢯࢰ࣮࣒⑓࡛࠶ࡿ࣒ࢥከ⢾⑕ࡢ◊✲ࢆ㐍ࡵ࡚࠸ࡲࡋࡓࠋࡑࡢࡼ࠺࡞⫼ᬒ࠿ࡽࠊ࣌ࣝ࢜࢟

ࢩࢯ࣮࣒⑓ࡢ◊✲࡟ࡶ๓ྥࡁ࡟ྲྀࡾ㎸ࡳࡸࡍ࠸⎔ቃࡀ࠶ࡾࡲࡋࡓࠋࡉࡽ࡟ಙᕞ኱Ꮫࡢᶫᮏ㝯ඛ⏕ࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢᇶ♏◊✲࡟ྲྀࡾ⤌ࢇ࡛࠾ࡾࠊᒱ㜧኱Ꮫࡀඹྠ◊✲ࢆጞࡵࡿࡇ࡜࡟࡞ࡾࡲࡋࡓࠖ࡜ୗ⃝ඛ⏕ࡣ᣺ࡾ㏉ࡿࠋࡑࡶࡑࡶ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣ  ᖺ࡟࣑ࢡࣟ࣎ࢹ࢕࣮࡜࠸࠺ᙧ࡛Ⓨぢࡉࢀࠊ ᖺ࡟࣌ࣝ࢜࢟ࢩࢯ࣮
࣒࡜ྡ௜ࡅࡽࢀ࡚࠸ࡓࠋ
ࠕ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡣ⣽⬊ෆ࢜ࣝ࢞ࢿࣛ࡜࿧ࡤࢀࡿ⣽⬊ෆᑠჾᐁࡢ୍ࡘ࡛ࡍࠋࣛ࢖ࢯࢰ࣮࣒ࡸ࣑ࢺࢥ
ࣥࢻࣜ࢔࡜ẚ࡭ࡿ࡜◊✲ࡢṔྐࡀὸ࠸ࡓࡵ࡟⌧ᅾ࡟⮳ࡗ࡚ࡶ༑ศ࡟▱ࢀࢃࡓࡗ࡚࠸ࡲࡏࢇࠖ࡜ୗ⃝ඛ⏕ࡣㄝ᫂ࡍࡿࠋ
◊✲ࡢࡁࡗ࠿ࡅ࡟࡞ࡗࡓ =HOOZHJHU ⑕ೃ⩌ࡣ  ᖺ࡟ࠊ⬻ࠊ⫢⮚ࠊ⭈⮚࡟㞀ᐖࢆᣢࡘཎᅉ୙᫂ࡢᐙ᪘
ᛶ⑕ೃ⩌࡜ࡋ࡚ሗ࿌ࡉࢀࠊ⬻⫢⭈⑕ೃ⩌࡜ࡶ࿧ࡤࢀࡓࠋ
 ᖺ࡟ =HOOZHJHU ⑕ೃ⩌ࡢᝈඣࡢ⫢⣽⬊࡛࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀḞᦆࡋ࡚࠸ࡿ࡜ุ᫂ࡍࡿࠋࡓࡔࡋࠊ
ࡇࡢ࡜ࡁ࡟ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ༑ศ࡟⌮ゎࡉࢀ࡚࠾ࡽࡎὀ┠ࡉࢀ࡞࠿ࡗࡓࠋ

㹺⛉Ꮫㄅࠕ6FLHQFH࡛ࠖୡ⏺ึࡢሗ࿌ ᖺࠊୗ⃝ඛ⏕ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࡀ =HOOZHJHU ⑕ೃ⩌ࡢ⑓ᅉ㑇ఏᏊ࡛࠶ࡿࡇ࡜ࢆ✺ࡁṆࡵࠊ⛉Ꮫㄅࠕ6FLHQFH࡛ࠖୡ⏺ึࡢⓎ⾲ࢆࡋࡓࠋࡇࡢ◊✲⤖ᯝࡣୡ⏺ⓗ࡟ࡶ⏬ᮇⓗ࡞Ⓨぢ࡛࠶ࡾࠊᅜ
ෆእࡢ་⒪࡟࢖ࣥࣃࢡࢺࢆ୚࠼ࡓࠋ
ୗ⃝ඛ⏕ࡣࠊ
ࠕ ᖺ࡟࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡀ࣑ࢺࢥࣥࢻࣜ࢔࡜ࡣ␗࡞ࡿș㓟໬⣔ࡢ௦ㅰࢆᢸ࠺Ꮡᅾ࡛
࠶ࡿ࡜ุ᫂ࡋࡓࡇ࡜ࡀ㌿ᶵ࡜࡞ࡾࠊࡑࢀ࠿ࡽಂ↛ὀ┠ࡉࢀࡿࡼ࠺࡟࡞ࡾࡲࡋࡓࠖ࡜ゎㄝࡍࡿࠋࡑࡢᚋࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒Ḟᦆࢆㄪ࡭ࡿࡇ࡜࡛࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢᶵ⬟ࡣᚎࠎ࡟ゎ᫂ࡉࢀ࡚࠸ࡃࡇ࡜
࡟࡞ࡿࠋ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ௦ㅰᶵ⬟ࡸඛኳᛶ༢⊂㓝⣲Ḟᦆ⑕ࡀሗ࿌ࡉࢀࠊ ᖺ௦ᚋ༙࡟࣌ࣝ࢜࢟ࢯ
ࢩ࣮࣒⑓ࡢᴫᛕࡀ☜❧ࡉࢀ࡚࠸ࡗࡓࠋ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ୺࡞ᙺ๭ࡣ⬡㉁ࡢ௦ㅰ࡛࠶ࡾࠊ≉࡟⬡⫫㓟ࡢș㓟໬ࢆᢸ࠺ࡇ࡜࡛࠶ࡿࠋᴟ㛗㙐⬡⫫㓟࡞࡝ࡢศゎ࡟㛵ࢃࡾࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒࡟㛵㐃ࡋࡓ㓝⣲Ḟᦆ࡟ࡼࡿ⑌ᝈࡀᚎࠎ࡟᫂ࡽ࠿࡟࡞ࡗ࡚ࡣ
࠸ࡓࡶࡢࡢࠊ=HOOZHJHU ⑕ೃ⩌ࡢཎᅉࡣศ࠿ࡽ࡞࠿ࡗࡓࠋ㓝⣲ࡢḞᦆ࡜ࡣูࡢ␗ᖖࡀ⪃࠼ࡽࢀ࡚࠸ࡓࠋ
ࡑ࠺ࡋࡓ୰࡛ࠕ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ 3(;ࠖࡀ㓝ẕ࡛ぢࡘ࠿ࡾࠊ᪥ᮏู࡛ࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒
ᙧᡂ㑇ఏᏊࡀࣛࢵࢺ࡛ぢࡘ࠿ࡿ࡜࠸࠺◊✲ᡂᯝࡀሗ࿌ࡉࢀ࡚࠸ࡓࠋ
ୗ⃝ඛ⏕ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ࡜ =HOOZHJHU ⑕ೃ⩌ࢆࡘ࡞ࡄᙜ᫬ࡣぢ࠼࡚࠸࡞࠸㛵㐃ᛶ࡟╔┠ࡋࠊ᪥ᮏ࡛ࣛࢵࢺࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࢆⓎぢࡋࡓ◊✲ࢢ࣮ࣝࣉ࡜ඹྠ◊✲ࢆ㐍ࡵࡿࡇ࡜࡟
࡞ࡿࠋࡇࡢ୰࡛ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢḞᦆࡋࡓᝈ⪅⣽⬊࡟ࢡ࣮ࣟࢽࣥࢢࡋࡓࣄࢺࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧ
ᡂ㑇ఏᏊࢆᑟධࡍࡿࡇ࡜࡟ࡼࡾࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࢆᅇ᚟ࡉࡏࡿࡇ࡜࡟ᡂຌࡋࡓࠋ
ࡉࡽ࡟ =HOOZHJHU ⑕ೃ⩌ࡢᝈඣ࡜୧ぶࡢ㑇ఏᏊゎᯒࢆ⾜ࡗ࡚ࠊᝈඣࡀ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ࡟ኚ␗ࢆᣢࡕࠊ୧ぶࡶᑐࡢ㑇ఏᏊࡢ∦᪉࡟ኚ␗ࢆᣢࡘࡇ࡜ࢆ☜ㄆࡋࡓࠋࡇࢀ࡟ࡼࡾ୧ぶ࠿ࡽཷࡅ⥅ࡀࢀࡓ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࡢ㑇ఏᏊኚ␗࡟ࡼࡗ࡚ᝈඣࡢ =HOOZHJHU ⑕ೃ⩌ࡀᖖᰁⰍయຎໃ㑇ఏᙧᘧ࡛Ⓨ⑕ࡋ࡚࠸ࡿ࡜✺ࡁṆࡵࡓࠋࠕࡇ࠺ࡋ࡚ࠊ=HOOZHJHU ⑕ೃ⩌ࡢ⑓ᅉ㑇ఏᏊࢆୡ⏺࡛ึࡵ࡚ሗ࿌ࡍࡿࡇ࡜࡟࡞ࡾࡲࡋࡓࠋࡑࢀࡲ࡛㑇ఏᛶ⑌ᝈ࡜࠸࠺࡜༢⊂㓝⣲Ḟᦆࡀ▱ࡽࢀ࡚࠸ࡲࡋࡓࡀࠊࡇࡢ⑕ೃ⩌࡛ࡣ㑇ఏᏊኚ␗࡟ࡼࡗ࡚㓝⣲Ḟᦆࡍࡿࡢ࡛ࡣ࡞ࡃࠊ࢜ࣝ࢞ࢿࣛࢆᙧసࡿࡇ࡜ࡀ࡛ࡁ࡞ࡃ࡞ࡿ࡜࠸࠺࣓࢝ࢽࢬ࣒࡛࠶ࡾᮍ▱ࡢࡶࡢ࡛ࡋࡓࠋࡑ
ࡇ࡟ࡣࠊ⑌ᝈࢆᘬࡁ㉳ࡇࡍཎᅉ࡟኱ࡁ࡞㐪࠸ࡀᏑᅾࡋ࡚࠸ࡲࡋࡓࠋ࡞࠾ࠊࡇࡢ⑓ែゎ᫂ࡣ =HOOZHJHU ⑕ೃ⩌ࡢᝈඣࢆ◊✲ࡍࡿᶵ఍࡟ᕠࡾྜࡗࡓ࠿ࡽࡇࡑᡂຌࡋࡓࡶࡢ࡛ࡍࠋ⑌ᝈࡢⓎ⑕࡟㛵ࢃࡿ࣓࢝ࢽࢬ࣒ࡢ
ゎ᫂ࢆྵࡵ࡚ࠊ་⒪ࡢᴫᛕࢆኚ࠼ࠊ᪂ࡋ࠸ᡬࢆ㛤࠸ࡓ◊✲࡜࡞ࡾࡲࡋࡓࠖ࡜ୗ⃝ඛ⏕ࡣ᣺ࡾ㏉ࡿࠋ㹺๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮デ⒪࢞࢖ࢻࣛ࢖ࣥࢆࡲ࡜ࡵࡿ
ୗ⃝ඛ⏕ࢆ୰ᚰ࡜ࡍࡿᒱ㜧኱Ꮫࡢ◊✲ࢢ࣮ࣝࣉࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ␗ᖖ⑕ࡢ⑓ᅉ㑇ఏᏊࢆḟࠎ࡜ゎ᫂ࡋࠊ ᖺ࡟  ␒┠ࡢ㑇ఏᏊࢆ≉ᐃࡋࡓࠋ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ⑓ែࡶᚎࠎ࡟᫂ࡽ࠿࡟࡞ࡾࠊ኱ࡁࡃ  ࡘࡢࢱ࢖ࣉ࡟ศ࠿ࢀࡿࡇ࡜ࡶ᫂☜࡟࡞ࡗࡓࠋ
୍ࡘࡣୗ⃝ඛ⏕ࡀゎ᫂ࡋࡓ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊ࡟㛵ࢃࡿ␗ᖖ࡛ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࢆᙧసࢀ
࡞࠸ࡓࡵ࡟㉳ࡇࡿ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ␗ᖖ⑕࡛࠶ࡿࠋ
ࡶ࠺୍ࡘࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒࡟ྵࡲࢀࡿ㓝⣲ࡸ⭷ࢱࣥࣃࢡࡢ༢⊂Ḟᦆ࡟ࡼࡿ⑌ᝈ࡛࠶ࡿࠋ࣌ࣝ࢜࢟ࢩ
ࢯ࣮࣒⑓࡛᭱ࡶከ࠸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮㸦$/'㸧࡞࡝ࡀྵࡲࢀࡿࠋ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ⑓ែゎ᫂ࡀ㐍ࡳࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ᙧᡂ㑇ఏᏊࡢᙺ๭ࡶ඲యീࡀ᫂ࡽ࠿࡟࡞ࡗ
ࡓࡀࠊࠕࡑࢀ࡛ࡶ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ⑓ែ࡟㛵ࡋ࡚ࡣࡲࡔࡲࡔᮍ▱ࡢ㒊ศࡀᑡ࡞ࡃࡣ࠶ࡾࡲࡏࢇࠖ࡜
ୗ⃝ඛ⏕ࡣゎㄝࡍࡿࠋ౛࠼ࡤࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ୺࡞⑓ែ࡜ࡋ࡚⚄⤒ኚᛶࡀ࠶ࡿࡀࠊ⬡㉁ࡢ௦ㅰ࡟␗ᖖࡀ㉳ࡁࡓሙྜ࡟
࡞ࡐ⚄⤒ኚᛶࡀ㉳ࡁࡿࡢ࠿ࡣᮍゎ࡛᫂ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ◊✲ࡣ⌧ᅾ㐍⾜ᙧ࡛ྲྀࡾ⤌ࡲࢀ࡚࠸ࡿࠋ
ࡑ࠺ࡋࡓୗ⃝ඛ⏕ࢆࡣࡌࡵୡ⏺ࡢ◊✲ࢢ࣮ࣝࣉࡢ◊✲ᡂᯝ࡟ࡼࡗ࡚࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢㄆ▱ᗘࡀ╔ᐇ࡟㧗ࡲࡗ࡚ࡁࡓࡢࡶ஦ᐇ࡛࠶ࡿࠋ
ᅜෆ࡛ࡣᣦᐃ㞴⑓࡜ࡋ࡚࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ୍ࡘࠊ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡀ  ᖺ  ᭶࡟ᣦᐃࡉࢀࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓㸦๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࢆ㝖ࡃ㸧ࡀྠᖺ  ᭶࡟ᣦᐃࡉࢀࡿࡇ࡜࡟࡞ࡿࠋ
ୗ⃝ඛ⏕ࡣཌປ⛉◊㞴἞ᛶ⑌ᝈᨻ⟇◊✲஦ᴗ࡛๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮デ⒪࢞࢖ࢻࣛ࢖ࣥࢆసᡂጤဨ

㛗࡜ࡋ࡚ᦠࢃࡾࠊ ᖺ࡟Ⓨหࠊ⌧ᅾࡶᨵゞ∧ࢆ⦅㞟୰࡛࠶ࡿࠋᾏእ࡟࠾࠸࡚ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ
ᩍ⛉᭩ࢆ  ᖺ  ᭶࡟Ⓨ⾜ࡋࠊᅜෆእࡢ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓デ⒪ࢆᨭ᥼ࡍࡿࠋ
ᒱ㜧኱Ꮫ࡛ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢデ᩿ࢩࢫࢸ࣒ࡢᵓ⠏ࡶ㐍ࡵࡓࠋ඲ᅜࡢ་⒪ᶵ㛵࠿ࡽ࣌ࣝ࢜࢟ࢩࢯ
࣮࣒⑓ࡢ␲࠸ࠊ࠶ࡿ࠸ࡣཎᅉ୙᫂ࡢ⚄⤒ኚᛶ⑌ᝈࡢデ᩿౫㢗ࢆཷࡅ௜ࡅࠊ὾ᯇ་⛉኱Ꮫ࡜ࡶ༠ຊࡋ࡚㑇ఏᏊኚ␗ࢆ≉ᐃࡍࡿ࡞࡝ࡋ࡚ṇ☜࡞デ᩿࡜἞⒪᝟ሗࢆᥦ౪࡛ࡁࡿࡼ࠺࡟ࡋ࡚࠸ࡿࠋࡉࡽ࡟⑌ᝈ᝟ሗࡸᝈ
⪅᳨యࢆ཰㞟ࡋࠊ⑓ែゎ᫂࡜἞⒪ἲࡢ㛤Ⓨࡶ㐍ࡵ࡚࠸ࡿࠋ◊✲ᐊࡢ㧗ᓥⱱ㞝ඛ⏕ࢆ୰ᚰ࡟࣌ࣝ࢜࢟ࢩࢯ
࣮࣒Ḟᦆࢮࣈࣛࣇ࢕ࢵࢩࣗࢆస〇ࠊ⮚ჾࡈ࡜ࡢⓎ⑕ᶵᗎࡢゎ᫂࠿ࡽࠊ⛶㨶ࡢὋࡂࡢ␗ᖖࡸయ⾲ࡀ㏱࡛᫂
࠶ࡿࡇ࡜ࢆ⏕࠿ࡋࡓ๰⸆ࢫࢡ࣮ࣜࢽࣥࢢࡢ㛤Ⓨ◊✲࡟ࡶྲྀࡾ⤌ࢇ࡛࠸ࡿࠋ

㹺᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࢆᐇ⌧ୗ⃝ඛ⏕ࡣ◊✲ࡢᡂᯝࢆ⮫ᗋ࡟⤖ࡧࡘࡅࠊデ⒪యไࡢᩚഛࡲ࡛άືࢆ῝ࡵ࡚࠸ࡿࠋ
୍ࡘࡣ⮬ࡽࡢ◊✲ᐊ࡛デ⒪࡟ࡶᑐᛂྍ⬟࡞⮫ᗋ᳨ᰝయไࢆᩚ࠼ࡓࡇ࡜࡛࠶ࡿࠋ
ୗ⃝ඛ⏕ࡢ◊✲ᐊ࡛ࡣࡶ࡜ࡶ࡜◊✲࡜ࡋ࡚࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ᝈ⪅ࡢ㑇ఏᏊゎᯒ࡞࡝ࢆ⾜ࡗ࡚࠸ࡓࡶ
ࡢࡢࠊ◊✲࡜ࡋ࡚ᑐᛂࡍࡿ㝈ࡾࡣ୺἞་࡟⤖ᯝࢆ㏉ࡍ㝿࡟ࠕ┤᥋ࠊデ᩿ࡢ⏝ࢆ࡞ࡉ࡞࠸ࠖ࡜࠸࠺ὀ㔘ࢆ௜ࡅࡿᚲせࡀ࠶ࡗࡓࠋ
ࠕࡑࢀ࡛ࡣᥦ౪ࡍࡿゎᯒ⤖ᯝ࡟ᑐࡋ࡚୺἞་ࡸᝈ⪅ࡉࢇࡣ୙Ᏻ࡟ᛮ࠺ࠖ࡜ୗ⃝ඛ⏕ࡣ⪃࠼ࠊ᳨ᰝᡭ㡰ࡢ⢭ᗘ⟶⌮ࢆᩚഛࡋࡓୖ࡛ࠊᴟ㛗㙐⬡⫫㓟᳨ᰝ࡟ࡘ࠸࡚ࡣ㞴⑓᳨ᰝ㒊㛛ࢆ㛤タࡋ࡚⑓㝔᳨ᰝ㒊ࡢ⟶⌮ୗ࡛⾜࠺࡜࡜ࡶ࡟ࠊ㑇ఏᏊ᳨ᰝ࡟ࡘ࠸࡚ࡣ⮬ࡽࡢ◊✲Ჷෆ࡟⾨⏕᳨ᰝᡤࢆタ⨨ࡍࡿ⾜ᨻᡭ⥆ࡁࢆ㐍ࡵࡓࠋࡑࡢ⤖ᯝ࡜ࡋ࡚ಖ㝤デ⒪࡟ࡶᑐᛂࡋࡓ⮫ᗋ᳨ᰝࡀྍ⬟࡜࡞ࡾࠊデ᳨᩿ᰝ⤖ᯝࡢಙ㢗ᛶࢆ㧗ࡵࡿࡇ࡜࡟࡞ࡗࡓࠋ

◊✲Ჷෆ࡟⑓㝔᳨ᰝ㒊㞴⑓᳨ᰝᐊࢆタ⨨ࡉࡽ࡟ࠊ᭱ࡶ⑕౛ࡀከ࠸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡶᐇ⌧ࡋࡓࠋ ᖺ ᭶࠿ࡽᒱ㜧┴࡛බⓗ࡟⾜ࢃࢀ࡚࠸ࡿ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ࡟๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮࡞࡝ࡢ᳨ᰝࡶ

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㏣ຍࡋ࡚ࠊᕼᮃ⪅ࡣ᭷ൾ᳨࡛ᰝࢆཷࡅࡽࢀࡿࡼ࠺࡟࡞ࡗࡓࠋࡑࡢ⤖ᯝࠊ ᭶࡟ࡣ┴ෆฟ⏕ࡢ 㸣㏆ࡃࡢ᪂⏕ඣࡀཷ᳨ࡋ࡚࠸ࡿࠋ
࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ୰࡛ࡶ᭱ࡶከ࠸๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡣ࣌ࣝ࢜࢟ࢩࢯ࣮࣒ࡢ⭷ࢱࣥࣃࢡ㉁ࡢ
୍ࡘ $%&' ࡢ㑇ఏᏊ␗ᖖ࡟ࡼࡾⓎ⑕ࡍࡿࡇ࡜ࡀศ࠿ࡗ࡚࠸ࡿࠋࡇࡢ⑌ᝈࡣ ; 㐃㙐ᛶ㑇ఏᙧᘧ࡛࠶ࡾࠊ⏨ᛶ࡟࠾࠸࡚୰ᯡ⚄⤒ࡢⓑ㉁ࡸ⬨㧊ࠊ๪⭈࡟㞀ᐖࢆ㉳ࡇࡍ࡯࠿ࠊዪᛶ࡛ࡶຍ㱋࡜ඹ࡟⬨㧊⑕ࢆ㉳ࡇࡍࡇ࡜ࡀ࠶ࡿࠋ㑇ఏᏊᆺ࡟୍⮴ࡋ࡞࠸」ᩘࡢ⮫ᗋᆺࢆ᭷ࡍࡿࡢࡀ≉ᚩ࡛ࠊከᙬ࡞⑕≧࡛Ⓨ⑕ࡍࡿࡓࡵ࡟⮫ᗋⓗ࡞᪩ᮇデ᩿ࡀ㞴ࡋ࠸ࡇ࡜ࡀၥ㢟࡟࡞ࡿࠋ⮫ᗋ⑓ᆺࡣ኱⬻ᆺ࡜࿧ࡤࢀࡿⓎ㐩㞀ᐖࡸ⾜ື㞀ᐖ࠿ࡽᩘᖺ࡛ᐷࡓࡁࡾ
࡟࡞ࡿ㔜⠜࡞⑓ᆺࡢ࡯࠿ࠊ⬨㧊⑕≧ࢆࡁࡓࡍ๪⭈⬨㧊ࢽ࣮ࣗࣟࣃࢳ࣮ࠊᑠ⬻ኻㄪ࡞࡝ࡀ㉳ࡇࡿᑠ⬻࣭⬻ᖿᆺࠊ๪⭈ᶵ⬟ࡀపୗࡍࡿ࢔ࢪࢯࣥᆺࡀ࠶ࡿࠋ኱⬻ᆺ࡟ᑐࡋ࡚၏୍ࡢ἞⒪ࡀⓎ⑕᪩ᮇࡢ㐀⾑ᖿ⣽⬊⛣᳜࡛࠶ࡾࠊ᪩ᮇデ᩿࡜᪩ᮇ἞⒪ࡀ㔜せ࡟࡞ࡿࠋⓎ⑕๓࠿ࡽᴟ㛗㙐⬡⫫㓟ࡀቑຍࡋ࡚࠸ࡿࡓࡵࠊᐙ⣔ෆゎᯒࡸ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡢᑟධࡀ᪩ᮇデ᩿࡟ࡘ࡞ࡀࡿࠋ
ᒱ㜧኱Ꮫ࡛ࡣ  ᖺ࡟ᐙ⣔ゎᯒ࡟ࡼࡿⓎ⑕๓デ᩿࡟ࡼࡗ࡚᪩ᮇ௓ධࡀྍ⬟࡜࡞ࡾⓎ⑕ࢆ㜵࠸ࡔ஦౛ࡀ࠶ࡾࠊࡇࢀࡀ㌿ᶵ࡟࡞ࡗࡓࠋⓎ⑕๓デ᩿ࡢព⩏ࡀㄆ㆑ࡉࢀ࡚ࠊ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢ᥎㐍࡟ࡘ࡞ࡀࡗࡓࠋୗ⃝ඛ⏕ࡣ  ᖺ࠿ࡽ」ᩘࡢᅜࡢࣉࣟࢪ࢙ࢡࢺ◊✲࡟ࡶཧຍࡋ࡚ࠊ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ᪂
⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢࡢ㛤Ⓨࠊయไᩚഛࢆ㐍ࡵࠊ๓㏙ࡢ㏻ࡾ  ᖺ㸲᭶࠿ࡽ᪩ᮇデ᩿࡟ࡘ࡞ࡀࡿ᳨
ᰝࡀጞࡲࡗࡓࠋ
ࡇࡢ᳨ᰝࡣࠊࡲࡎ᪂⏕ඣࡢ⾑ᾮ࠿ࡽᴟ㛗㙐⬡⫫㓟ࢆ᳨ฟࡋࠊ㝧ᛶ౛࡟ࡘ࠸࡚ࡣ⤖ᯝ࡜デ⒪᝟ሗࢆ୺἞
་࡟㏻▱ࡍࡿࠋࡑࡢୖ࡛ಖㆤ⪅࠿ࡽࡢྠពࢆᚓ࡚⢭ᐦデ᩿᪋タ࡟᳨యࢆ㏦ࡾࠊಖ㝤デ⒪᳨࡛ᰝࢆᐇ᪋ࡍ
ࡿࠋࡑࡢ⤖ᯝ࡟ᇶ࡙࠸࡚୺἞་ࡸ඲ᅜࡢ᪂⏕ඣ࣐ࢫࢫࢡ࣮ࣜࢽࣥࢢᐇ᪋᪋タࡀ㑇ఏ࢝࢘ࣥࢭࣜࣥࢢ࠿ࡽ
ᐙ⣔ෆゎᯒࠊ㛗ᮇணᚋ㏣㊧ࢆ⾜࠺࡜࠸࠺௙⤌ࡳ࡛࠶ࡿࠋࡓࡔ⌧≧࡛ࡣⓎ⑕๓࡟デ᩿ࡋ࡚ࡶ⑓ᆺண ࡣ㞴ࡋࡃࠊࢫࢡ࣮ࣜࢽࣥࢢ᳨ᰝࢆࡼࡾᝈ⪅ࡢ฼┈࡟ࡘ࡞ࡆࡿࡓࡵ࡟ࡣ⑓ᆺࢆつᐃࡍࡿせᅉࡢゎ᫂ࡀୡ⏺୰࡛ᮇᚅࡉࢀ࡚࠸ࡿࠋ
୍᪉ࠊ኱⬻ᆺࢆ᪤࡟Ⓨ⑕ࡋࡓᝈ⪅࡛ࡣ࡛ࡁࡿࡔࡅ᪩ᮇࡢデ᩿ࡀ㔜せ࡛ࠊ
ࠕⓎ⑕᪩ᮇࡣከᙬ࡞⑕≧ࢆ♧ࡍࡓࡵ࡟ᢸᙜ་ࡸᏛᰯࠊ♫఍ࡢၨⓎࡣḞ࠿ࡏࡲࡏࢇࠋ๪⭈ⓑ㉁ࢪࢫࢺࣟࣇ࢕࣮ࡢࣃࣥࣇࣞࢵࢺࢆタࡅ࡚ၨⓎ࡟ᙜࡓࡗ࡚࠸ࡲࡍࠋᗂඣᮇ࠿ࡽᛮ᫓ᮇࡲ࡛ࡢ㛫࡟ึᮇ⑕≧ࡸేⓎ⑕≧࡜ࡋ࡚ከ࠸ࡶࡢࡣࠊぢ࡙ࡽࡑ࠺࡟ࡋ࡚࠸ࡿࡶࡢࡢどຊ᳨ᰝ࡛␗ᖖࡀ࡞࠸ࠊᩳどࡀẼ࡟࡞ࡿࠊ▱ⓗ㞀ᐖࡸ⮬㛢⑕ࠊⴠࡕ╔ࡁࡢ࡞ࡉࠊᏛ
⩦ᅔ㞴࡞࡝࡟ὀពࡀᚲせ࡛ࡍࠋデ᩿ࡢయไࢆ☜❧ࡍࡿࡇ࡜ࡶ㔜せ࡟࡞ࡾࡲࡍࠋデ᩿ᚋࡣࠊ࡛ࡁࡿࡔࡅ㎿㏿࡟㦵㧊ࣂࣥࢡࡸ⮖ᖏ⾑ࣂࣥࢡ࠿ࡽ +/$ ࡢᆺࡀ୍⮴ࡋࡓ㐀⾑ᖿ⣽⬊⛣᳜࡟ࡘ࡞ࡆࡿࡇ࡜ࡀ㔜せ࡟࡞ࡾࡲࡍࠖ࡜ୗ⃝ඛ⏕ࡣヰࡍࠋୗ⃝ඛ⏕ࡣࡇࢀ࠿ࡽࡶ࣌ࣝ࢜࢟ࢩࢯ࣮࣒⑓ࡢ◊✲ᡂᯝࢆ⮫ᗋ࡟ࡘ࡞ࡆࠊ ே࡛ࡶከࡃࡢ㞴⑓ᝈ⪅ࡢணᚋᨵၿࢆ┠ᣦࡍάືࢆ⥅⥆ࡍࡿࠋୗ⃝ඛ⏕ࡢ⟶⌮ࡍࡿ㑇ఏᏊ᳨ᰝᐊࡀⓏ㘓⾨⏕᳨ᰝᡤ࡛࠶ࡿࡇ࡜ࢆᥖ♧ࡋ࡚࠸ࡿୗ⃝ఙ⾜㸦ࡋࡶࡊࢃ࣭ࡢࡪࡺࡁ㸧ඛ⏕ᒱ㜧኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ࢤࣀ࣒◊✲ศ㔝ᩍᤵ ᖺࠊᒱ㜧኱Ꮫ་Ꮫ㒊ࢆ༞ᴗࠋ㫽ྲྀ኱Ꮫࠊᒱ㜧┴❧ᒱ㜧⑓㝔࡞࡝ࢆ⤒࡚ࠊ ᖺᒱ㜧኱Ꮫᑠඣ⛉ㅮᖌࠊ ᖺࢺࣟࣥࢺᑠඣ⑓㝔ࠊ ᖺᒱ㜧኱Ꮫᑠඣ⛉ຓᩍᤵࠊ ᖺ࡟ྠ኱Ꮫ⏕࿨⛉Ꮫ⥲ྜ◊✲ᨭ᥼ࢭࣥࢱ࣮ࢤࣀ࣒◊✲ศ㔝ᩍᤵࠊ࠾ࡼࡧᑠඣ⛉ే௵ᩍᤵࠋ ᖺࡼࡾྠ኱Ꮫ኱Ꮫ㝔㐃ྜ๰⸆་⒪᝟ሗ◊✲⛉་⒪᝟ሗᏛᑓᨷᩍᤵࠋ ᖺࡼࡾྠ኱Ꮫ㧗➼◊✲㝔⛉Ꮫ◊✲ᇶ┙ࢭࣥࢱ࣮ ࢤࣀ࣒◊✲ศ㔝ᩍᤵࠋ ᖺࡼࡾྠ኱Ꮫ⢾㙐⏕࿨ࢥ࢔◊✲ᡤ⢾㙐ศᏊ⛉Ꮫ◊✲ࢭࣥࢱ࣮ᩍᤵࠋ
࣒ࢥከ⢾ࣉࣟࢧ࢖ࢺྲྀᮦ࣏࣮ࣞࢺ 

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