Plenary Lecture
September 12 (Tue) 16:50-17:50 Room A (501)
Chair: Yaichiro Kotake (Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)
PL-1

Challenges in Nucleic Acid Therapeutics for Malignant Pleural Mesothelioma◯ Hidetoshi Tahara(Dep. Cell. Mol. Biol, Grad. Sch. Biomedical & Health Sci., Hiroshima Univ)

Educational Lecture
September 13 (Wed) 11:00-11:40 Room A (501)
Chair: Shuntaro Hara (Sch. of Pharm., Showa Univ.)
EL-1

Education of Pharmaceutical Sciences：Present and Future◯ Shigeru Ohta
(Fac. Pharm. Sci.,Wakayama Medical Univ.)

Award Lectures
Scientific Award
September 13 (Wed) 13:00-13:30 Room A (501)
Chair: Hisamitsu Nagase (Gifu Univ. of Med. Sci.)
AL-1

Application of in vivo bio-imaging to research on pharmaceutical health sciencesand environmental toxicology◯ Tsuyoshi Nakanishi(Gifu Pharmaceutical Univ.)

Kanehara Award
September 13 (Wed) 13:30-13:50 Room A (501)
Chair: Yoshito Kumagai (Grad. Sch. Pharm. Sci., Kyushu Univ.)
AL2-1

A modelling of metal exposomes based on electrophilic metals◯ Masahiro Akiyama(Fac. Pharm., Keio Univ)−53−

September 13 (Wed) 13:50-14:10 Room A (501)
Chair: Kouichi Yoshinari (Sch. Pharm. Sci., Univ. Shizuoka)
AL2-2

Unraveling the molecular mechanisms of chemical toxicity focusing on thefunctions of xenobiotic-sensing nuclear receptors◯ Ryota Shizu(Sch. Pharm. Sci., Univ Shizuoka)

Invited Lecture
September 12 (Tue) 10:30-11:00 Room A (501)
Chair: Yaichiro Kotake (Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)
IL-1

Emerging role of Sestrin2 as key regulator in the maintenance of homeostasis inliver pathophysiology◯ Sung Hwan Ki(Laboratory of Molecular Toxicology, College of Pharmacy, Chosun University)

Forum Ⅰ : Expectations for pharmaco-health sciences in forensic
toxicology -So far and from now onSeptember 12 (Tue) 14:40-16:40 Room A (501)
Organizer / Chair: Akira Namera (Grad. Sch. Biomed. Health Sci., Hiroshima Univ.)
Yasumitsu Ogra (Grad. Sch. Pharm. Sci., Chiba Univ.)
F1-1

Cooperation and Harmony between Pharmaceutical Science and Forensic
Medicine in Cause of Death Investigation◯ Toshikazu Kondo(Dept. Forensic Med., Wakayama Med. Univ.)

F1-2

The role of pharmacy schools in the Basic Act on Promotion of Death Investigationand its social expectations in Japan◯ Satoshi Numazawa(Showa Univ. Sch. Pharm.)

F1-3

Current status and required pharmacological knowledge of forensic toxicology inthe investigation of cause of death◯ Akira Namera(Grad. Sch. Biomed. Health Sci., Hiroshima Univ.)

−54−

F1-4

The role of pharmaceutical professionals in forensic medicine◯ Katsuhiro Okuda, Masaru Asari, Yuta Takahashi, Keiko Shimizu(Dep. Leg. Med., Asahikawa Med. Univ.)

Forum Ⅱ : New perspectives on organelle biology & toxicology
pioneered by young scientists
September 13 (Wed) 9:00-11:00 Room A (501)
Organizer / Chair: Atsushi Matsuzawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
Yaichiro Kotake (Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)
F2-1

Low concentrations of MPP+ promote glucose metabolism and impair autophagy◯ Masatsugu Miyara, Yaichiro Kotake(Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)

F2-2

Sequestration of toxic metals by SeP/lysosome pathway◯ Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

F2-3Novel inhibitory mechanisms of cancer cell metastasis through liquid-liquid phaseseparation of p62 and NBR1
◯ Takuya Noguchi, Atsushi Matsuzawa(Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

F2-4

Regulation of cell cycle and tumorigenesis via functional communication between
endoplasmic reticulum and nucleus◯ Atsushi Saito, Yasunao Kamikawa, Taichi Ito, Kazunori Imaizumi(Inst. Biochem, Dept. Biomed. Health Sci., Hiroshima Univ.)

Forum Ⅲ : Nutritional significance of fat-soluble vitamins in themaintenance and promotion of health and prevention
and treatment of disease
September 13 (Wed) 14:20-16:20 Room A (501)
Organizer / Chair: Hirotaka Imai (Sch. Pharm. Sci. Kitasato Univ.)
Kimie Nakagawa (Fac. Pharm. Sci., Kobe Gakuin Univ.)
F3-1

Chronic kidney disease and vitamin A◯ Yutaka Taketani1, Yuichiro Adachi1,2, Natsumi Yamamoto1, Hirokazu Ohminami1,
Masashi Masuda1(1Medical Nutrition., Tokushima Univ, 2Harvard Medical School.)

−55−

F3-2

The relationship of vitamin D deficiency to disease risks and its improvement◯ Akiko Kuwabara(Fac. Human Life and Ecology., Osaka Metropolitan Univ.)

F3-3

Research of vitamin E function using tissue specific GPx4 deficient mice
◯ Hirotaka Imai
（Sch. Pharm. Sci., Kitasato Univ.）

F3-4

Importance of Vitamin K Nutrition and Risk of Disease Due to Vitamin K
Deficiency◯ Kimie Nakagawa(Fac. Pharm. Sci., Kobe Gakuin Univ.)−56−

2023 Japan/Korea Joint Symposium on Pharmaceutical Health
Science and Environmental Toxicology
September 12 (Tue) 11:00-12:00 Room A (501)
Chair: Joohee Jung (Duksung Women's University)
Takuya Noguchi (Tohoku University)
S-1

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling
multiple cancer relevant pathways and immunogenic cell death
Hyesung Lee, Seong Hun Lim, ◯ Do Sik Min(College of Pharmacy, Yonsei University)

S-2

α1-Antitrypsin/Proteinase 3 imbalance promotes nonalcoholic steatohepatitis
through proteolytic regulation of IL-32γ
Jeong-Su Park1, Jin Lee2, Feng Wang1, Hwan Ma1, Yong-Sun Lee3, Sang-Gyu Lee4,
Bumseok Kim5, Jin Tae Hong1, ◯ Yoon-Seok Roh1,*(1College of Pharmacy and Medical Research Center, Chungbuk National University,
Cheongju 28160, South Korea; 2Department of Pathology, School of Medicine,
University of California, San Diego, La Jolla, CA 92093, USA; 3Toxicological
Evaluation and Research Department, National Institute of Food and Drug Safety
Evaluation, Ministry of Food and Drug Safety,Cheongju 28159, Republic of Korea;
4
College of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea; 5College
of Veterinary Medicine and Biosafety Research Institute, Jeonbuk National University,
Iksan 54596, South Korea)

S-3

Establishment and characterization of genetic mouse model of polycystic ovary
syndrome◯ Daisuke Matsumaru1, Riko Yoshida1, Yuta Mori1, Keishi Ishida1, Kyoko Mekada1,
Hozumi Motohashi2, Tsuyoshi Nakanishi1(1 Laboratory of Hygienic Chemistry and Molecular Toxicology, Gifu Pharmaceutical
University, 1 Department of Gene Expression Regulation, Institute of Development,
Aging and Cancer, Tohoku University)

S-4

A new aspect of selenoprotein P/ApoER2 pathway as a therapeutic target against
glioblastoma◯ Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)−57−

2023 Japan/Korea Joint Symposium on Pharmaceutical Health
Science and Environmental Toxicology : Poster Session
September 12 (Tue) 13:10-14:30 Room C (101)
PS-01

Elucidation of the protective mechanism of a food-derived compound against
ferroptosis◯ Ryota Kojima1, Yusuke Hirata1, Takuya Noguchi1, Yoichi Kurokawa2,
Atsushi Matsuzawa1(1Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 2Dept. of Biosci.
and Biotech., Fukui Prefect. Univ.)

PS-02

Environmentally relevant doses of bisphenol A stimulate estradiol production by
regulating β-catenin-FOXL2-CYP19A1 pathway in human ovarian granulosa cells◯ Haifeng Liu1, Hanyong Jin2, Guenhwi Kim1, Jeeyeong Kim1, Jeehyeon Bae1
(1School of Pharmacy, Chung-Ang University, Seoul, 06974, South Korea, 2Key
Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education,
College of Pharmacy, Yanbian University, Yanji, 133002, Jilin Province, China)

PS-03

Green algae Chlamydomonas reinhardtii acquire adaptability to copper stress bydefense and tolerance/recovery responses◯ Ryotaro Tsutsumi1, Risa Yoshimoto2, Jiro Miura3, Takuya Yamashita1,
Kazumasa Hirata1,2, Kazuya Nagano1,2(1Sch. Pharm. Sci., Wakayama Medical Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
Grad. Sch. Dent. Sci., Osaka Univ.)

PS-04

Downregulation of IL-10 reduces autophagy and invasion in breast cancer◯ Young Keun Hwang1,2, Hao Jin1, Yeji Hong1,2, Joohee Jung1,2, Aree Moon1,2(1 Duksung IDC, Duksung Women's Univ., 2 Coll. Pharm., Duksung Womenʼs Univ.)

PS-05

Exploring mRNA markers for assessing developmental neurotoxicity using
primary rat neurons◯ Ryoga Fujihara, Masatsugu Miyara, Yuki Takehara, Tomoki Takabayashi,
Yuki Yamamoto, Hidetoshi Tahara, Yaichiro Kotake(Grad. Sch.Biomed. Health Sci., Hiroshima Univ.)

PS-06

Impressic acid ameliorate diesel exhaust particles-induced NLRP1 inflammasomein human keratinocyte cells◯ Seung Yeon Lee, Gi Ho Lee, Ju Yeon Chae, Jae Won Kim, Sang Won Seo,
Hye Gwang Jeong(Department of Toxicology, College of Pharmacy, Chungnam National University,
Daejeon, Republic of Korea.)−58−

PS-07

AdipoR2 counteracts saturated fatty acid-induced lipotoxicity by its saturated
fatty acid-selective phospholipase A2 activity◯ Yutaro Yagi1, Hiroki Kawana1, Kuniyuki Kano1, Nozomu Kono1, Hiroaki Tanabe2,
Miki Okada-Iwabu3, Masato Iwabu3, Toshimasa Yamauchi3, Takashi Kadowaki4,
Shigeyuki Yokoyama2, Junken Aoki1(1Dept. of Health Chem., Grad. Sch. of Pharm. Sci., The University of Tokyo, 2RIKEN
Clust. for Sci., Technol. & Innov. Hub, 3Dept. of Diabetes & Metab. Dis., Grad. Sch. ofMed., The University of Tokyo, 4Toranomon hosp.)

PS-08

Anti-angiogenesis and anti-cancer effects of fisetin in colorectal cancer patientderived organoid xenograft model◯ Nayun Kim1,2, Junhye Kwon3,4, Ui Sup Shin3,4, Joohee Jung1,2*(1Duksung IDC, Duksung Women's Univ., 2Coll. Pharm., Duksung Womenʼs Univ.,
3
Dep. Radiol. Clinic. Res., Korea Cancer Center Hospital, 4KIRAMS)

PS-09

A mechanism underlying metabolic remodeling of selenium in inflammation◯ Hayato Takashima, Mayumi Sugawara, Kotoko Arisawa, Takayuki Kaneko,
Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

PS-10

Weight of Evidence for Chemical Hazard Assessment in the Reproductive andDevelopmental Toxicity◯ Sunyi Lee1, Jae-Ho Shin2, Sanghee Park3, Sanghyeon Yeon3, Myongsil Hwang4,
Myung-Ha Song5, Sanghee Lee5, Jungkwan Seo5, Hyomin Lee6, Joohee Jung1(1College. Pharm., Duksung Womenʼs Univ., 2 Dept. Biomed. Lab. Sci., Eulji Univ.,
3
Chemtopia Co., 4College. Bio-nano Technol., Gachon Univ., 5Risk Assessment Div.,
NIER, 6Risk Mgmt. Inst. Co.)

PS-11

Search for the endogenous ligand of MrgB5 and MRGX4, oxidized phospholipid
GPCRs involved in itch-sensing◯ Yugo Takagi, Jumpei Omi, Junken Aoki
(Fac. Pharm. Sci., The University of Tokyo)

PS-12

Phenotypic characterization and role of TGF-β+ regulatory natural killer cells in
atopic dermatitis mice
◯ Min Yeung Choi1,2, Keun Young Min1, Min Geun Jo1, Wahn Soo Choi1,
and Young Mi Kim2
(1Dep. Immunol., Sch. Med., Konkuk Univ., 2College Pharm. Duksung Womenʼs Univ.)

PS-13

Selenoprotein P/ApoER2 axis plays a crucial role in intracellular selenium storage◯ Atsuya Ichikawa, Kotoko Arisawa, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)−59−

PS-14

Potential toxicity of polystyrene nanoplastics with different surface charge inhuman lung epithelial BEAS-2B cells and HaCaT keratinocytes◯ So Young Kyung, Joo Hee Han, Joo Kyung Shin, Eunah Lee, Hwa Young Cha,
Jae Hyeon Park, Hyung Sik Kim(Sch. Pharm., Sungkyunkwan Univ.,)

PS-15

Effect of human serum albumin on post-mortem metabolism of organophosphorus
insecticides◯ Yoshikazu Yamagishi1, Hirotaro Iwase1, Yasumitsu Ogra1,2(1Graduate School of Medicine, Chiba University, 2Graduate School of Pharmaceutical
Sciences, Chiba University)

PS-16

Safety assessment of Cnidium Officinale rhizome extract in cosmetics using theThreshold of Toxicological Concern (TTC) approach◯ Soha Jeon1, Eun-Young Lee2, Prima F. Hillman2, Sang-Jip Nam2,and Kyung-Min Lim1
(1College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
2
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760,
Republic of Korea)

PS-17

Functional analysis of long-chain acyl-CoA synthetase (ACSL)4 in chemicalinduced lung injury◯ Yuki Tomitsuka, Hiroshi Kuwata, Shuntaro Hara
(Sch. of Pharmacy, Showa Univ.)

PS-18

The effect of estrogen receptor alpha 36 on multi-drug resistance 1/P-glycoprotein
expression in human triple negative breast cancer cells◯ Gi Ho Lee, Poyonov Muslimbek, Seung Yeon Lee, Ju Yeon Chae, Jae Won Kim,
Hye Gwang Jeong(Department of Toxicology, College of Pharmacy, Chungnam National University,
Daejeon, Republic of Korea.)

PS-19

Exploration of candidate drugs to induce metallothionein3◯ Mizuki Tsuru1, Kazuki Komai1, Kazuki Ohuchi1, Yasuhiro Shinkai2,
Tomoki Kimura3, Nobuhiko Miura4, Yoshito Kumagai5, Isao Hozumi1,
Masatoshi Inden1, Hisaka Kurita1(1Fac. Pharm. Sci., Gifu Pharmaceutical Univ, 2Sch. Life Sci., Tokyo Univ. Pharm. andLife Sci., 3Fac. Pharm. Sci., Setsunan Univ, 4Fac. Pharm. Sci., Yokohama Univ. Pharma,
5
Fac. Pharm. Sci., Kyushu Univ.)

PS-20

The inhibitory effects of supersulfides on oxidative stress-induced parthanatos◯ Yutaro Yamada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)−60−

PS-21Acyl-CoA synthetase long-chain family member 4 (ACSL4) links inflammationand carcinogenesis in a mouse model of colitis-associated cancer◯ Tsubasa Ochiai, Hiroshi Kuwata, Shuntaro Hara
(Sch. of Pharm., Showa Univ.)

PS-22

Prostacyclin synthase negatively regulates the inflammatory reactions caused bylipopolysaccharide-induced sepsis in vivo
◯ Toshiya Honsawa1, Tsubasa Ochiai1, Chieko Yokoyama2, Hiroshi Kuwata1,
Shuntaro Hara1(1Sch. of Pharm., Showa Univ., 2Kanagawa Inst. of Tech.)

PS-23

Lead induces novel necrosis-like cell death in differentiating neurons◯ Satoru Shiina, Takayuki Kaneko, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)−61−

Award Candidates Presentation Candidates for Young Investigator Award
September 12 (Tue) 9:00-10:30 Room A (501)
Chair: Atsushi Matsuzawa (Grad. Sch. Pharm. Sci., Tohoku Univ.)
Maternal exposure to TCDD elicits disruption of nicotinic acid metabolism in fetal
A-1(P-102) hypothalamus: possible mechanism involved in the reduced steroidogenesis◯ Mana Fujimoto1, Hiroe Sano1, Ren-Shi Li1,2, Hong-Bin Chen1, Takayuki Koga3,
Yoshitaka Tanaka1, Yuji Ishii1(1Grad Sch Pharm Sci, Kyushu Univ., 2China Pharm Univ., 3Daiichi Univ. Pharmacy)
Activation of fibrinolytic system of human vascular endothelial cells by
A-2(P-032) γ-irradiation and its mechanisms◯ Miyabi Kobayashi1, Lihito Ikeuchi1, Tsuyoshi Nakano2, Kazuki Kitabatake1,
Chika Yamamoto2, Mitsutoshi Tsukimoto1, Tomoya Fujie1, Toshiyuki Kaji1(1Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2Fac. of Pharm. Sci., Toho Univ.)
Lipoxytosis regulator Lipo-2 involved in Sudden Cardiac Death
A-3(P-029) ◯ Ryuya Kobayashi, Masaki Matsuoka, Hirotaka Imai
(Grad. Sch. Pharm. Sci., Kitasato Univ.)
Analysis of the effects of long-chain acyl-CoA synthetase (ACSL) 4 deficiency on
A-4(P-044) drug-induced lung injury◯ Yuki Tomitsuka, Hiroshi Kuwata, Shuntaro Hara
(Sch. of Pharmacy, Showa Univ.)
Functional analysis of vitamin K converting enzyme UBIAD1 in bone formation
A-5(P-164) ◯ Shunsuke Hirashima1, Yukino Kiyooka2, Shinichiro Kaetsu2, Kimie Nakagawa1,2(1 Grad. Sch. Pharm. Sci., Kobegakuin Univ, 2 Fac. Pharm. Sci., Kobegakuin Univ.)
Selenoprotein P/ApoER2 axis plays a crucial role in intracellular selenium storage
A-6(P-016) ◯ Atsuya Ichikawa, Kotoko Arisawa, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)
Lead induces novel necrosis-like cell death in differentiating neurons
A-7(P-018) ◯ Satoru Shiina, Takayuki Kaneko, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)
Thyroid hormone (TH) promotes urinary excretion of 2,3,7,8-tetrachlorodibenzoA-8(P-112) p -dioxin (TCDD) via the function of TH receptor (TR) β in mice
◯ Shunsuke Tomita1, Pinyapach Dungkokkruad2, Youhei Hiromori3, Keishi Ishida1,
Daisuke Matsumaru1, Hisamitsu Nagase4, and Tsuyoshi Nakanishi1(1 Gifu Pharm. Univ., 2 Mahasarakham Univ., 3 Suzuka Univ. of Med. Sci., 4 Gifu Univ.
of Med. Sci.)−62−

The inhibitory effects of supersulfides on oxidative stress-induced parthanatos
A-9(P-028) ◯ Yutaro Yamada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)−63−

Award Candidates Presentation Candidates for Rookie of the Year Award
September 12 (Tue) 9:00-10:30 Room B (404)
Chair: Hitomi Fujishiro (Fac. Pharm. Sci., Tokushima Bunri Univ.)
Functional analysis of vitamin K-converting enzyme (UBIAD1) in adipose tissue
B-1(P-166) using Tamoxifen-inducible gene-deficient mice
◯ Rika Horigome1, Momoka Nagura1, Haruka Saeki1, Shunsuke Hirashima2,
Kimie Nakagawa1,2(1Fac. Pharm. Sci., Kobe Gakuin Univ, 2Grad. Sch. Pharm. Sci., Kobe Gakuin Univ.)
A mechanism underlying metabolic remodeling of selenium in inflammation
B-2(P-012) ◯ Hayato Takashima, Mayumi Sugawara, Kotoko Arisawa, Takayuki Kaneko,
Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)
The relationship between maternal thyroid-related parameters and brain
B-3(P-147) development in offspring under chemical-induced hypothyroidism◯ Manami Koizumi1, Keishi Ishida1, Saori Kasuya1, Kanoko Tatsumi1,
Kyoko Mekada1, Daisuke Matsumaru1, Aki Murashima1, Hisamitsu Nagase2,
Yasunari Kanda3, Kazuhiro Takuma4, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Gifu Uni. of Med Sci., 3NIHS, 4Osaka Univ.)
Metabolism and nutritional availability of methylated-selenium metabolites
B-4(P-013) produced by gut microflora in rats
◯ Sayano Iijima1, Kazuaki Takahashi2, Yasumitsu Ogra3(1Fac. Pharm. Sci., Chiba Univ., 2Grad. Sch. Hort., Chiba Univ., 3Grad. Sch. Pharm.
Sci., Chiba Univ.)
Elucidation of the protective mechanism of a food-derived compound against
B-5(P-030) ferroptosis◯ Ryota Kojima1, Yusuke Hirata1, Takuya Noguchi1, Yoichi Kurokawa2,
Atsushi Matsuzawa1(1Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 2Dept. of Biosci.
and Biotech., Fukui Prefect. Univ.)
Effect of furosemide to the expression of ion transporters on brain in neonatal
B-6(P-140) chronic lung disease◯ Hiroki Kurokawa1, Atsuto Onoda1,2, Yoshiaki Sato2, Xu Yue2,3, Ken Tachibana1,
Ken Takeda1(1Dep. Pharm., Sanyo-Onoda City Univ, 2Cent. Mat-Neo., Nagoya Univ. Hosp. 3Grad.
Med., Nagoya)−64−

Effects of Fetal Exposure to Ultrafine Particles on Brain Development in a Model
B-7(P-106) of Setd5 Deficiency◯ Risa Fuku, Atsuto Onoda, Tadashi Nakagawa, Ken Tachibana, Ken Takeda(Fac. Pharm. Sanyo- Onoda city Univ.)
Effect of fetal growth restriction on brain development: Expression levels of OX2
B-8(P-173) glycoprotein in oligodendrocytes◯ Ayumi Yamato, Atsuto Onoda, Ken Tachibana, Ken Takeda(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)
PXR-dependent inhibition of the proliferation of ERα-positive breast cancer cells
B-9(P-165) ◯ Kazuki Ota, Takuomi Hosaka, Aoi Yoshihara, Ryota Shizu, Yuichiro Kanno,
Kouichi Yoshinari(Sch. Pharm. Sci., Univ. Shizuoka)
The selective androgen receptor modulator YK11 regulates binding of
B-10(P-178) transcriptional coactivators through NTD and AF2 interactions in androgen
receptor◯ Tomohiro Kosuge, Ryota Shizu, Takuomi Hosaka, Yuichiro Kanno,
Kouichi Yoshinari(Sch. Pharm. Sci, Univ. Shizuoka)−65−

Oral Session 1
September 12 (Tue) 14:40-15:40 Room B (404)
Chair: Tomoki Kimura (Fac. Pharm. Sci., Setsunan Univ.)
Yumi Abiko (Grad. Sch. Bio. Sci., Nagasaki Univ.)
O1-1

Low-dose radiation affects developing human iPSC-derived retinal ganglion
organoid◯ Hideko Sone1,2, Mari Katsura3,4, Tomohiro Ito2, Hiroko Nansai1, Youichiro Wada1(1Grad. Sch. Pharm. Sci., Univ. Pharm. Yokohama, 2HERD, NIES, 3ISC, Univ. Tokyo,
4
Reiwa Eye Clinic, 5Grad. Sch. Med. Sci., Univ. Tokyo, ISC / RCAST, Univ. Tokyo)

O1-2

Effect of Benzo[a]pyrene on IL-17 mediated signaling◯ Kota Nariya, Ryuta Muromoto, Tadashi Matsuda(Grad. Sch. Pharm. Sci., Hokkaido Univ)

O1-3

The affection of the changes of polycyclic aromatic hydrocarbons and1-nitropyrene in Shenyang, China from 2014 to 2020
◯ Hao Zhang1, Xuan Zhang1, Yan Wang1, Pengchu Bai1, Lulu Zhang2,3, Chong Han4,
Qimin Wang5, Yunping Cai5, Seiya Nagao3, Akira Toriba6, Ning Tang3,5,7(1Grad. Sch. Medical Sci., Kanazawa Univ, 2 Inst. Civil Eng., Archit. Environ., Hubei
Univ. Technol. 3Inst. Nature and Environ. Technol., Kanazawa Univ. 4Sch. Metall.,
Northeastern Univ., China, 5Coll. Energy and Power, Shenyang Inst. Eng., China, 6Inst.
Biomedi. Sci. Nagasaki Univ. 7Inst. Medical, Pharm. and Health Sci., Kanazawa Univ.)

O1-4

Personal exposure and health effect of polycyclic aromatic hydrocarbons forhealthy residents: a pilot study in heavy-polluted cities of China◯ Xuan Zhang1, Hao Zhang1, Yan Wang1, Pengchu Bai1, Lulu Zhang2,3, Akira Toriba4,
Yongjie Wei5, Ning Tang3,6,7(1Grad. Sch. Medical Sci., Kanazawa Univ., 2Inst. Civil Eng., Archit. Environ., Hubei
Univ. Technol., 3Inst. Nature and Environ. Technol., Kanazawa Univ. 4Inst. Nature andEnviron. Technol., Kanazawa Univ. 5Inst. Biomedi. Sci. Nagasaki Univ. 6Inst. Medical,
Pharm. and Health Sci., Kanazawa Univ. 7Coll. Energy and Power, Shenyang Inst. Eng.,
China)

O1-5

Concentration variation of air pollutants at a Japanese background site, Wajima
from 2016 to 2021
◯ Pengchu Bai1, Hao Zhang1, Xuan Zhang1, Yan Wang1, Lulu Zhang2,3, Seiya Nagao3,
Akira Toriba4, Ning Tang3,5(1Grad. Sch. Medical Sci., Kanazawa Univ., 2Inst. Civil Eng., Archit. Environ., Hubei
Univ. Technol., 3 Inst. Nature and Environ. Technol., Kanazawa Univ., 4 Inst. Biomedi.
Sci. Nagasaki Univ., 5 Inst. Medical, Pharm. and Health Sci., Kanazawa Univ.)−66−

Oral Session 2
September 12 (Tue) 15:40-16:40 Room B (404)
Chair: Kayoko Kita (Fac. Pharm. Sci., Teikyo Univ.)
Takashi Toyama (Grad. Sch. Pharm. Sci., Tohoku Univ.)
O2-1

Detection of bisphenol A diglycidyl ether (BADGE) and their derivatives in infants
admitted to neonatal intensive care unit (NICU)◯ Atsuto Onoda1,2, Mami Kuwamura3, Kentaro Tanaka3, Kentaro Taki2,
Chihaya Koriyama4, Rie Tanaka3, Ken Tachibana1, Ken Takeda1,
Toshihiro Kawamoto3, Mayumi Tsuji3(1 Fac. Pharm. Sci., Sanyo-Onoda U., 2 Fac. Med. Sci., Nagoya U., 3 U. Occup. Env.
Health., 4 Kagoshima U. Grad. Sch. Med. Sci.)

O2-2

Effects of Bisphenol A replacement chemicals, BPAF, BPB, and BPS, on the
proliferation of ER-positive MCF-7 breast cancer cells: A comparative study
between single and repeated exposure system◯ Michitaka Tanaka1, Masayo Hirao-Suzuki1, Jun-ichi Shimoda1, Shuso Takeda2,
Masufumi Takiguchi1(1Fac. Pharm. Sci., Hiroshima Intl. Univ., 2Fac. Pharm. Pharmaceut. Sci., Fukuyama
Univ.)

O2-3

Human biomonitoring survey: an attempt to collect biological samples via thepostal method◯ Miyuki Iwai-Shimada1, Kenta Iwai1, Mai Takagi1, Nozomi Tatsuta2,
Yayoi Kobayashi1 Shoji F. Nakayama1(1Health. Environ. Risk, National Institute for Environmental Studies, 2Grad. Sch. Med.,
Tohoku Univ.)

O2-4

Tributyltin induces LC3-II accumulation independent of autophagy initiation
complex◯ Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ.)

O2-5

Silver nanoparticle-induced autophagic disruption and Rubicon expression inhuman alveolar epithelial adenocarcinoma cells◯ Takamitsu Miyayama, Masato Matsuoka(School of Medicine, Tokyo Womenʼs Medical University)−67−Oral Session 3
September 13 (Wed) 9:00-10:00 Room B (404)
Chair: Yasuhiro Shinkai (Sch. Life. Sci., Tokyo Univ of Pharm and Life Sci.)
Yuu Miyauchi (Fac. Pharm. Sci., Sojo Univ.)
O3-1

Analysis of the association between PEPT2 expression and AhR in human lungderived H441 cells◯ Maya Nakanishi1, Masashi Kawami2, Ryoko Yumoto2, Mikihisa Takano3,
Yasuo Uchida2(1Fac. Pharm. Sci., Hiroshima Univ, 2Grad. Sch. of Biomed. and Health Sci., Hiroshima
Univ., 3Fac. Pharm. Sci., Yasuda Women Univ.)

O3-2

Mechanism underlying abemaciclib-induced epithelial-mesenchymal transition inalveolar epithelial cell line, A549
◯ Tomoyo Yoshimori1, Masashi Kawami1, Yuta Kumagai2, Ryoko Yumoto1,
Mikihisa Takano3, Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Sch. Pharm. Sci., Hiroshima
Univ., 3Fac. Pharm. Sci., Yasuda Women Univ.)

O3-3Role of p53 in miR-34a-induced epithelial-mesenchymal transition in non-smalllung cancer cells◯ Mizuki Akai1, Masashi Kawami1, Hiroto Namiuchi2, Ryoko Yumoto1,
Mikihisa Takano3, Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Sch. Pharm. Sci., Hiroshima
Univ., 3Fac. Pharm. Sci., Yasuda Women Univ.)

O3-4

Relationship between purine nucleotide analogue sensitivity and
10-formyltetrahydrofolate metabolizing enzyme expression in hepatocellular
carcinoma cells◯ Masato Sasaki1, Kazuo Yamamoto2, Takeshi Ueda3, Hayato Irokawa1, Ryoya Sekine1,
Kouki Takeda1, Yutaka Tanaka1, Fumie Ito1, Shusuke Kuge1, Nobuyuki Shibata1(1Fac. Pharm. Sci., Tohoku Med. Pharm. Univ., 2Biomed. Res. Supp. Center, Nagasaki
Univ. Sch. Med., 3Fac. Med., Kindai Univ.)

O3-5

Effects of estrogenic condition on expression of fatty acid 2-hydroxylase (FA2H) in
estrogen receptor α-positive breast cancer cells◯ Masayo Hirao-Suzuki1, Koki Kanameda2, Takayuki Koga3, Masufumi Takiguchi1,
Narumi Sugihara2, Masahiro Ohara4, Shuso Takeda2(1Fac. Pharm. Sci., Hiroshima Intl. Univ., 2Fac. Pharm. Pharmaceut. Sci., Fukuyama
Univ., 3Daiichi Univ. Pharm., 4Saitama Med. Univ. Intl. Med. Cent.)−68−Oral Session 4
September 13 (Wed) 10:00-11:00 Room B (404)
Chair: Seigo Sanoh (Sch. Pharm. Sci., Wakayama Med. Univ.)
Yuka Sasaki (Sch. of Pharm., Showa Univ.)
O4-1

Study on the factors associated with the ribavirin resistance in breast cancer cells
MCF-7 cells◯ Airi Fukushima1, Masashi Kawami1, Yuki Sugimoto2, Ryoko Yumoto1,
Mikihisa Takano3, Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Sch. Pharm. Sci., Hiroshima
Univ., 3Fac. Pharm. Sci., Yasuda Women Univ.)

O4-2

De novo phospholipid synthesis driven by autophagy-related genes is required forsaturated fatty acid-induced IRE1a activation◯ Nozomu Kono1, Shenwei Ni1, Shunsuke Kasai1, Sosuke Akagi1, Hiroyuki Arai2,
and Junken Aoki1(1Grad. Sch. of Pharmeut. Sci., Univ. of Tokyo.; 2Grad. Sch. of Med., Univ. of Tokyo)

O4-3

Histological change accompanied by the stress-induced thymic involution◯ Kei Nakayama, Kaito Fukuda, Hiroshi Hasegawa(Lab. Hygienic Sci., Kobe Pharm. Univ.)

O4-4

Linalool alters the expression levels of drug-metabolizing enzymes in the brain◯ Taichi Fujiyama, Ami Oguro, Yaichiro Kotake(Grad. Sch. of Biomed. and Health Sci, Hiroshima Univ,)

O4-5

Prediction of oligomer-forming site of UDP-glucuronosyltransferases◯ Yuu Miyauchi1, Madoka Sawai2, Shinji Takechi1, Peter Mackenzie3, Yuji Ishii4(1 Fac. Pharmaceut. Sci., Sojo Univ., 2 Sch. Pharm. at Fukuoka, Int. Univ. Health &Welfare, 3Dept. Clin. Pharmacol., Coll. Med. & Pub. Health, Flinders Univ., 4Grad. Sch.
Pharm. Sci., Kyushu Univ.)

Oral Session 5
September 13 (Wed) 14:20-15:20 Room B (404)
Chair: Shigeaki Hida (Fac. Pharm. Sci., Nagoya City Univ.)
Yusuke Hirata (Grad. Sch. of Pharm. Sci., Tohoku Univ.)
O5-1

Detection of SARS-CoV-2 and Influenza viruses in the atmosphere◯ Akira Aoki1, Hirokazu Adachi2, Miyu Hibino1, Miyabi Itou2, Yoshihiro Yasui2,
Yoshinori Okamoto1, Hideto Jinno1(1Fac. Pharm., Meijo Univ., 2Aichi Pref. Inst. Public Health)

−69−

O5-2

Innate immune reactions by PEPT2-mediated transport of bacterial dipeptides inalveolar macrophages◯ Yutaka Takeuchi1, Kosuke Fujii2, Masashi Kawami1, Ryoko Yumoto1,
Mikihisa Takano3, Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Sch. Pharm. Sci., Hiroshima
Univ., 3Fac. Pharm. Sci., Yasuda Women Univ.)

O5-3

Metabolic Shift to Aerobic Glycolysis in HIV-1 Infection: Triosephosphate
Isomerase 1 Contributes to Efficient Viral Replication◯ Towa Abe1, Naoki Kihsimoto1, Satoshi Miura1, Tae Yasutake1, Nobutoki Takamune1,
Shogo Misumi1(1Grad. Sch. Pharm. Sci., Kumamoto Univ. 2KIDO, Kumamoto Univ.)

O5-4

Diversity of HIV transmission controlled by metabolic dynamics◯ Naoki Kishimoto1, Satoshi Miura1, Tae Yasutake1, Towa Abe1, Nobutoki Takamune2,
Shogo Misumi1(1 Grad. Sch. Pharm. Sci., Kumamoto Univ., 2 KIDO)

O5-5

H2O2-Zn2+ signaling induces age-related nigral dopaminergic neurodegeneration
after exposer to paraquat◯ Atsushi Takeda1, Haruna Tamura1, Miki Sasaki1, Hiroki Morioka1, Ryusuke Nishio1,
Haruna Tamano1,2(1 Sch. Pharm. Sci., Univ. Shizuoka, 2 Shizuoka Tohto Med. Col.)

Oral Session 6
September 13 (Wed) 15:20-16:20 Room B (404)
Chair: Shuso Takeda (Fac. Pharm. Sci., Fukuyama Univ.)
Tomoya Fujie (Fac. of Pharm. Sci., Tokyo Univ. of Sci.)
O6-1

Effect of high fat diet-feeding on the ketone body-utilizing pathway in brown
adipose tissue◯ Masahiro Yamasaki, Shinya Hasegawa, Masahiko Imai, Shotaro Ozaki,
Noriko Takahashi(Dep. of Health Chem., Hoshi Univ)

O6-2

Dephosphorylation of lysophosphatidic acid by soluble epoxide hydrolase (sEH)
and its function in the brain◯ Yurino Kaga, Ami Oguro, Yaichiro Kotake(Grad. Sch. of Biomed. and Health Sci, Hiroshima Univ)

−70−

O6-3

Mechanism of lipid oxidation dependent cell death by persulfide◯ Shu Yasuda1, Takara Hashimoto1, Maho Morita1, Tomohiro Sawa2,
Tomoko Koumura1, Hirotaka Imai1(1Grad. Sch. Pharm. Sci., Kitasato Univ, 2Grad. Sch. Med. Sci., Kumamoto Univ.)

O6-4

Functional analysis of Lipo-1 in Lipoxytosis◯ Masaki Matsuoka, Shotaro Hatanaka, Hirotaka Imai
(Sch. of Pharm., Kitasato Univ.)

O6-5

Effects of an immune modulator FTY720 (fingolimod) on signaling pathways that
control cell proliferation in fission yeast◯ Kanako Hagihara1,2, Ryosuke Satoh2, Takuya Maeda1, and Reiko Sugiura2(1Dept. Pharm., Sch. Pharm., Hyogo Med. Univ., 2Lab. of Mol. Pharmacogenom., Fac.
of Pharm., Kindai Univ.)−71−

Poster Session
September 12 (Tue) 13:10-14:30 Room C (101)P-001

Trial Exposure of Mice to Heated Tobacco Aerosols◯ Sawako Shindo1, Chisato Takahashi1, Shiori Nishikawa1, Madoka Nihei1,
Kodai Tsukada1, Kazuhiko Nakadate1, Yohei Inaba2, Akira Ushiyama2, Kenji Hattori1(1Fac. Pharm. Sci., Meiji Pharm. Univ., 2Dep. Env. Health, NIPH)

P-002

Inhibition of p38 mitogen-activated protein kinases attenuates methylmercury
toxicity in SH-SY5Y neuroblastoma cells◯ Yasukazu Takanezawa, Kazuma Sakai, Ryosuke Nakamura, Yuka Ohshiro,
Shimpei Uraguchi, Masako Kiyono(Dep. Public Health. Sch of Pharm., Kitasato Univ.)

P-003

Involvement of polycyclic aromatic hydrocarbons and endotoxin in macrophage
expression of interleukin-33 induced by exposure to particulate matter◯ Nami Ishihara1, Tomoaki Okuda2, Christoph FA Vogel3, Yasuhiro Ishihara1,3(1Hiroshima Univ, 2Keio Univ, 3 University of California)

P-004

Elbow jet separation of Beijing urban particles and their responses to macrophages◯ Yasuhiro Ishihara1, Yu Nabetani2, Yuto Tani3, Chiharu Tokoro3, Hiroshi Okochi3(1Hiroshima Univ, 2Miyazaki Univ, 3Waseda Univ.)

P-005

Autophgy response to toxic metal exposure in SH-SY5Y neuroblastoma cells◯ Yuki Ohashi, Yasukazu Takanezawa, Kazuma Sakai, Ryosuke Nakamura,
Yuka Ohshiro, Shimpei Uraguchi, Masako Kiyono(Dep. Public Health. Sch of Pharm., Kitasato Univ.)

P-006

Determination of atmospheric microplastics in Kanazawa, Japan◯ Yan Wang1, Hao Zhang1, Xuan Zhang1, Pengchu Bai1, Lulu Zhang2,3, Kohei Ono4,
Seiya Nagao3, Akira Toriba5, Atsushi Matsuki3, Ning Tang3,6,7(1Grad. Sch. Medical Sci., Kanazawa Univ., 2Inst. Civil Eng., Archit. Environ., Hubei
Univ. Technol., 3Inst. of Nature and Environ. Technol., Kanazawa Univ.,4Grad. Sch.
Natural Sci. and Technol., Kanazawa Univ., 5Inst. of Biomedi. Sci. Nagasaki Univ., 6
Inst. of Medical, Pharm. and Health Sci., Kanazawa Univ., 7Coll. Energy and Power,
Shenyang Inst. Eng., China)

P-007

In vitro and in silico analysis of human TRP channels activation by isothiazolinone
antibiotics◯ Momoka Urashima1, Rina Nakamukai1, Yumira Miyazaki1, Susumu Ohkawara1,
Yoko Mori2,3, Ikuo Kawamura1, Nobuhiko Miura1, Takashi Isobe1, Nobumitsu Hanioka1,
Hideto Jinno3, Toshiko Tanaka-Kagawa1(1Yokohama Univ. Pharm., 2Natl. Inst. Environ. Studies, 3Facul. Pharm., Meijo Univ.)−72−

P-008

Effects of alkyl chain length, cationic core atoms, and anionic species of ionicliquids on cytotoxicity toward mouse macrophage J774.1 cells◯ Toshio Hirokawa, Takahito Nishiyama, Ryousuke Suda, Kyoko Fujita,
Kimiyoshi Ichida, Satoshi Yamaori(Tokyo University of Pharmacy and Life sciences)

P-009

Effects of di-(2-ethyl hexyl) phthalate metabolites on transcriptional activity via
human nuclear receptors and gene expression in HepaRG cells◯ Ayaka Yasuda1, Wataru Murase1, Atsuhito Kubota1, Naoto Uramaru2,
Katsuhiro Okuda3, Ryo Hakota1, Atsuko Ikeda-Araki4,5, Hiroyuki Kojima1,5(1Sch. Pharm. Sci., Health Sci. Univ. Hokkaido, 2Nihon Pharm. Univ., 3Asahikawa Med.
Univ., 4Grad. Sch. Health. Sci., Hokkaido Univ., 5Cent. Env. Health Sci., Hokkaido
Univ.)

P-010

Evaluation of xenopus AhR responsiveness to various chemicals using A8-XRELuc cells◯ Tarou Kawaguchi1, Taito Matueda1, Takaaki Inomata2, Koudai Takano2, Kumi Matui 3,
Masashi Sekimoto1,2(1Grad. Sch. Environ. Health Sci., Azabu Univ, 2Sch. Life Environ. Sci., Azabu
Univ.,3Fac. Veterinary Sci., Azabu Univ.)

P-011

Sensory nerve predominant peripheral neurotoxicity of methylmercury is caused
by infiltrated macrophage-derived TNF-α storm◯ Toshiyuki Kaji1, Tsuyoshi Nakano2, Eiko Yoshida3, Shigekatsu Kazama1,
Chika Yamamoto2, Yasuyuki Fujiwara4, Komyo Eto5, Yo Shinoda4(1Fac. Pharm., Tokyo Univ. Sci., 2 Fac. Pharm., Toho Univ., 3 CRIEPI, 4Sch. Pharm.,
Tokyo Univ. Pharm. Life Sci., 5Health Nurs. Fac. for the Aged, Jushindai)

P-012

A mechanism underlying metabolic remodeling of selenium in inflammation◯ Hayato Takashima, Mayumi Sugawara, Kotoko Arisawa, Takayuki Kaneko,
Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-013

Metabolism and nutritional availability of methylated-selenium metabolites
produced by gut microflora in rats
◯ Sayano Iijima1, Kazuaki Takahashi2, Yasumitsu Ogra3(1Fac. Pharm. Sci., Chiba Univ., 2Grad. Sch. Hort., Chiba Univ., 3Grad. Sch. Pharm.
Sci., Chiba Univ.)

P-014

Alteration of intracellular free zinc concentration by the heavy metal-dependenttranscription factor MTF-1◯ Misaki Tanaka, Haruka Inazuka, Tae Shimoyama(Fac. Pharm. Sci., Teikyo Univ.)−73−

P-015

Effect of cystine transporter inhibitor on arsenic accumulation and spindle
assembly checkpoint activation in HeLa cells treated with thio-dimethylarsinicacid◯ Kayoko Kita, Tatsuya Sunada, Taro Honma, Toshihide Suzuki(Fac. Pharma-Sci., Teikyo Univ.)

P-016

Selenoprotein P/ApoER2 axis plays a crucial role in intracellular selenium storage◯ Atsuya Ichikawa, Kotoko Arisawa, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-017

Molecular mechanism underlying the methylation of inorganic tellurium salt
◯ Ayuka Takata1, Yu-ki Tanaka2, Yoshikazu Yamagishi3, Yasunori Fukumoto2,
Noriyuki Suzuki2, Yasumitsu Ogra2(1Fac. Pharm. Sci., Chiba Univ, 2Grad. Sch. Pharm. Sci., Chiba Univ, 3Grad. Sch. Med.,
Chiba Univ.)

P-018

Lead induces novel necrosis-like cell death in differentiating neurons◯ Satoru Shiina, Takayuki Kaneko, Takashi Toyama, Yoshiro Saito(Grad. Sch. Pharm. Sci., Tohoku Univ.)

P-019

Involvement of integrins in cadmium-induced injury of vascular endothelial celllayer
◯ Natsumi Ichida1, Kentaro Sayama2, Takato Hara2, Toshiyuki Kaji1,
Chika Yamamoto2, Tomoya Fujie1(1 Fac. Pharm. Sci., Tokyo Univ. of Sci., 2 Fac. Pharm. Sci., Toho Univ.)

P-020

Role of OSGIN1 in the induction of neuronal cell death by methylmercury◯ Naoya Yamashita, Marino Uchiyama, Ryota Yamagata, Gi-Wook Hwang(Fac. Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.)

P-021

Involvement of TNFR3 in neurobehavioral changes of mice exposed tomethylmercury during embryonic and developmental stages◯ Ryota Yamagata, Yurina Uesugi, Naoya Yamashita, Gi-Wook Hwang(Fac. of Pharmaceut. Sci., Tohoku Med. Pharmaceut. Univ.)

P-022

Toxicity mechanism of organic iron compounds using the chemical properties andcytotoxicity◯ Masaki Takaishi, Mahiro Saito, Leona Tsuyukubo, Akio Kobayashi(Dept. Pharm. Sci., Intl. Univ. Health Welfare)−74−P-023

Effects of cadmium on the renin-angiotensin system of mouse kidney and bloodvessels◯ Kanaho Odashima1, Miho Takase1, Ayumu Iseki2, Yayoi Tsuneoka2,3, Takato Hara1,
Yasuyuki Fujiwara2, Chika Yamamoto1(1Fac. Pharm. Sci., Toho Univ., 2Sch. Pharm., Tokyo Univ. Pharm and Life Sci., 3Fac.
Pharma-Sci., Teikyo Univ.)

P-024

Contribution of claudin-5 and ZO-1 to cadmium-induced detachment injury invascular endothelial cells◯ Chiaki Nakata1, Haruka Katayama1, Mayuka Asatsu1, Takato Hara1, Tomoya Fujie2,
Chika Yamamoto1(Fac. Pharm. Sci., Toho Univ.)

P-025

Trace elements control and manganese accumulation in TPN patients◯ Masumi Motonaga1,2, Akiko Ohkawa2, Tomoko Tamada2, Yuta Eguchi2,
Kousuke Noma2, Ayaka Suzawa2, Tetsushi Sutoh2, Nanami Fujii2, Toshiko Shimotaka2,
Kazumi Sugihara1, Hideo Mawatari3(1Faculty of Pharmaceutical Sciences, Hiroshima International University, 2Hiroshima
Prefectural Rehabilitation Center, 3Hiroshima Prefectural Rehabilitation Support
Center)P-026

Rhododendrol suppresses the differentiation of 3T3-L1 cells into adipocytes◯ Naoto Uramaru, Kawashima (Katagiri) Azusa, Makoto Osabe, Toshiyuki Higuchi(Div. Pharm. Health Biosci., Nihon Pharm. Univ.)

P-027

Effect of nobiletin administration on the expression of thioredoxin-interacting
protein (TXNIP) in the brain of Alzheimer’s disease model mice
◯ Kotaro Ishibashi1, Wei Dai1, Hiroaki Takemoto1, Hikaru Kasuya1, Takashi Saito2,3,
Takaomi C. Saido3, Yasushi Ohizumi4, Kiyomitsu Nemoto1(1Fac. Pharm. Sci., Toho Univ, 2Grad. Sch. Med. Sci., Nagoya City Univ., 3RIKEN
Center for Brain Sci., 4Tohoku Univ.)

P-028

The inhibitory effects of supersulfides on oxidative stress-induced parthanatos◯ Yutaro Yamada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-029

Lipoxytosis regulator Lipo-2 involved in Sudden Cardiac Death◯ Ryuya Kobayashi, Masaki Matsuoka, Hirotaka Imai
(Grad. Sch. Pharm. Sci., Kitasato Univ.)−75−

P-030

Elucidation of the protective mechanism of a food-derived compound against
ferroptosis◯ Ryota Kojima1, Yusuke Hirata1, Takuya Noguchi1, Yoichi Kurokawa2,
Atsushi Matsuzawa1(1Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ., 2Dept. of Biosci.
and Biotech., Fukui Prefect. Univ.)

P-031

The caspase-mediated tissue-specific degradation of the nuclear receptor PPARγ◯ Makoto Osabe, Toshiyuki Higuchi(Div. Pharm. Health Biosci., Nihon Pharm. Univ.)

P-032

Activation of fibrinolytic system of human vascular endothelial cells by
γ-irradiation and its mechanisms◯ Miyabi Kobayashi1, Lihito Ikeuchi1, Tsuyoshi Nakano2, Kazuki Kitabatake1,
Chika Yamamoto2, Mitsutoshi Tsukimoto1, Tomoya Fujie1, Toshiyuki Kaji1(1Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2Fac. of Pharm. Sci., Toho Univ.)

P-033

Mitochondrial DNA maintaining mechanism was depending on autophagy◯ Kenji Hattori, Ayana Ohisi, Reika Kohinata(Fac. Pharm. Meiji Pharmaceutical Univ.)

P-034

Regulatory mechanism of glycosaminoglycan elongation enzymes expression in
prliferating vascular endothelial cells at grown culture by TGF-β1◯ Takuya Uzawa, Tatsutoshi Matsumura, Natsumi Endo, Fuwano Horikawa,
Takato Hara, Chika Yamamoto(Fac. Pharm. Sci., Toho Univ.)

P-035

ATP potentiates hydrogen peroxide-induced vascular endothelial cell damage◯ Tomoki Inami, Tsuyoshi Nakano, Chika Yamamoto(Fac. of Pharm. Sci., Toho Univ.)

P-036

Neurodegeneration and neurogenesis in methylmercury-exposed rat dorsal root
ganglion◯ Yo Shinoda1, Yuka Sekiguchi1, Ayaka Matsuki1, Eiko Yoshida2, Tsutomu Takahashi1,
Toshiyuki Kaji3, Yasuyuki Fujiwara1(1Sch. Pharm., Tokyo Univ. Pharm. Life Sci., 2CRIEPI, 3Fac. Pharm., Tokyo Univ. Sci.)

P-037

Toxicity mechanism induced by the combination of flunitrazepam andchlorpromazine using mouse brain microdialysis◯ Kota Nakajima1, Asuka Kaizaki-Mitsumoto2, Satoshi Numazawa2(1 Grad. Sch. Pharm. Sci., Showa Univ., 2Sch. Pharm., Showa Univ.)−76−P-038Establishment of pain assessments for intermediate frequency magnetic field◯ Shin Ohtani1, Akira Ushiyama2, Keiji Wada3, Yukihisa Suzuki3, Kenji Hattori1(1Meiji Pharm. Univ, 2National Institute of Public Health, 3Tokyo Metropolitan Univ.)

P-039

Investigation of rosin-related substances contained in medical patches as causative
substances for allergic contact dermatitis◯ Tsuyoshi Kawakami1, Maiko Tahara1, Akiko Yagami2, Yoshiaki Ikarashi1(1NIHS, 2 Fujita Health Univ. School Med. Bantane Hospital)

P-040

Prostacyclin synthase negatively regulates the inflammatory reactions caused bylipopolysaccharide-induced sepsis in vivo
◯ Toshiya Honsawa1, Tsubasa Ochiai1, Chieko Yokoyama2, Hiroshi Kuwata1,
Shuntaro Hara1(1Sch. of Pharm., Showa Univ., 2Kanagawa Inst. of Tech.)

P-041

Development of a cellular assay for small-molecule antivirals targeting the main
protease of SARS-CoV-2 at biosafety level 1◯ Yasunori Fukumoto, Reina Hara, Noriyuki Suzuki, Yu-ki Tanaka, Yasumitsu Ogra
(Grad. Sch. Pharm. Sci., Chiba Univ.)

P-042

Search for the endogenous ligand of MrgB5 and MRGX4, oxidized phospholipid
GPCRs involved in itch-sensing◯ Yugo Takagi, Jumpei Omi, Junken Aoki
(Fac. Pharm. Sci., The University of Tokyo)

P-043

Carbon black nanoparticles induce cytotoxic effects in alveolar macrophages◯ Tomohiro Ishihara, Atsushi Furukawa, Yuka Nagata, Ryo Suzuki(Fac Pharm Sci, Kanazawa Univ)

P-044

Analysis of the effects of long-chain acyl-CoA synthetase (ACSL) 4 deficiency on
drug-induced lung injury◯ Yuki Tomitsuka, Hiroshi Kuwata, Shuntaro Hara
(Sch. of Pharmacy, Showa Univ.)

P-045

Extracellular cysteine regulates oxidative and electrophilic stresses in HepG2 cells◯ Hanako Aoki1, Yasuhiro Shinkai1,2,5, Masahiro Akiyama2,4, Satoshi Yamazaki1,2,
Motohiro Nishida5, Yoshito Kumagai1,2,3(1Grad. Sch. Med Sci., Tsukuba Univ., 2Fac. Medicine., Tsukuba Univ., 3Sch. Life. Sci.,
Tokyo Univ of Pharm and Life Sci., 4Fac. Pharm., Keio Univ., 5Grad. Sch. Pharm. Sci.,
Kyushu Univ.)−77−P-046

Exploration of selenoproteins involved in the induction of insulin resistance in type2 diabetes◯ Hirofumi Ogino1, Koichi Murano2, Tomofumi Okuno3, Hitoshi Ueno3(1Fac. Pharm. Sci., Nihon Pharmaceutical Univ, 2 Osaka Institute of Public Health. 3Fac.
Pharm. Sci., Setsunan Univ.)

P-047

Photodynamic therapy induces HO-1 and CSE via Nrf2 activation in humanglioblastoma cells◯ Tsutomu Takahashi1, Keiko Miura1, Kanon Masamoto1, Natsumi Nishi1, Yo Shinoda1,
Jiro Akimoto2, Yasuyuki Fujiwara1(1Sch. of Pharm., Tokyo Univ. of Pharm. and Life Sci., 2Tokyo Med. Univ.)

P-048

The effect of the bacterial lectin (PFL) from Pseudomonas fluorescens Pf0-1 on thelipid profile of human breast cancer cell T47D
◯ Kohei Kawabata, Yuichiro Sato, Akira Tokumura, Hiroyuki Nishi, Kinjiro Morimoto(Fac. Pharm., Yasuda Womenʼs University)

P-049

Role of microsomal prostaglandin E synthase (mPGES)-1 in chemical-induced
bladder carcinogenesis◯ Yuka Sasaki1, Tsubasa Ochiai1, Yuki Endo2, Yasutomo Suzuki2, Yukihiro Kondo2,
Shuntaro Hara1(1Sch. of Pharmacy, Showa Univ, 2Nippon Medical School)

P-050

Proteoglycan synthesis prevents the generation of advanced glycation endproducts◯ Takato Hara, Chika Yamamoto(Fac. Pharm. Sci., Toho Univ.)

P-051

Androgen-dependent gene expression of CUX2 leads to that of the drug
metabolizing enzymes and drug transporters in the pig liver◯ Misaki Kojima1,2, Masakuni Degawa3, Kiyomitsu Nemoto2(1Natl. Agric. Food Res. Org., 2Dep. Mol. Toxicol., Fac. Pharm. Sci., Toho Univ., 3Lab.
Mol. Toxicol., Sch. Pharm. Sci., Univ. Shizuoka.)

P-052

Effect of human serum albumin on post-mortem metabolism of organophosphorus
insecticides◯ Yoshikazu Yamagishi1, Hirotaro Iwase1, Yasumitsu Ogra1,2(1 Graduate School of Medicine, Chiba University, 2 Graduate School of Pharmaceutical
Sciences, Chiba University)−78−P-053

Role of interleukin-6 in the downregulation of hepatic drug transporters by cecal
ligation and puncture-induced sepsis◯ Takashi Ashino1, Yuki Nakamura2, Hirokazu Ohtaki3, Yoichiro Iwakura4,
Satoshi Numazawa1(1Showa Univ. Sch. Pharm., 2Yokohama Univ. Pharm., 3Tokyo Univ. Pharm. Life Sci.,
4
Tokyo Univ. Sci.)

P-054

Aberrant photoperiod affects hyperglycemia induced by corticosterone in mice
◯ Hiroshi Kawai, Koki Takeda, Reiko Iwadate(Fac. Pharm. Pharmaceut. Sci., Josai Univ)

P-055

Cell culture on vegetable-originated paper◯ Fumiya Sueyoshi, Kousei Nagayoshi, Kansei Moriyasu, Toshiyuki Oshima,
Tomofumi Fujino(Tokyo Univ. Pharm. Life Sci.)

P-056

Geometrical isomerization of arachidonic acid upon lipid peroxidation serves as anegative feedback mechanism in ferroptosis◯ Carla Ferreri1, Yusuke Hirata2, Yuto Yamada2, Wakana Suzuki2, Saya Takano2,
Takuya Noguchi2, Chryssostomos Chatgilialoglu1, Atsushi Matsuzawa2(1The Institute of Organic Synthesis and Photoreactivity-National Research Council,
Bologna, Italy, 2Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.,
Sendai, Japan)

P-057

Evaluation of adsorption mechanism of mercury using mangosteen via elemental
distribution and binding energy analyses◯ Chalermpong Saenjum1, Fumihiko Ogata2, Yugo Uematsu2, Titikan Mongkolsiri1,
Naohito Kawasaki2(1Fac. Pharm., Chiang Mai Univ., Thailand, 2Fac. Pharm., Kindai Univ., Japan)−79−September 13 (Wed) 16:30-17:50 Room C (101)P-101Preparation of the carbonaceous material produced from waste cotton and its
adsorption capability of crystal violet from aqueous phase◯ Fumihiko Ogata, Kazuki Sugimura, Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

P-102

Maternal exposure to TCDD elicits disruption of nicotinic acid metabolism in fetal
hypothalamus: possible mechanism involved in the reduced steroidogenesis◯ Mana Fujimoto1, Hiroe Sano1, Ren-Shi Li1,2, Hong-Bin Chen1, Takayuki Koga3,
Yoshitaka Tanaka1, Yuji Ishii1(1Grad Sch Pharm Sci, Kyushu Univ., 2China Pharm Univ., 3Daiichi Univ. Pharmacy)

P-103

The effect of microplastics degraded by sunlight on macrophage◯ Yurika Wada1, Yoko Iwamoto1,2, Yu Nabetani3, Yasuhiro Ishihara1,2(1 Sch Integr Arts Sci, Hiroshima Univ, 2 Grad Sch Integr Sci Life, Hiroshima Univ, 3Facul Engineer, Miyazaki Univ.)

P-104

Polymethoxyflavonoid nobiletin restores developmental retardation elicited bymaternal exposure to low-dose dioxin◯ Ryoto Hiyama1, Hongbin Chen1, Chiho Ohta2, Nobuyuki Koga2, Yoshitaka Tanaka1,
Yuji Ishii1(1Kyushu Univ., 2Nakamura Gakuen Univ.)

P-105

Analysis of the properties of airborne particles collected in Sanyo-Onoda City,
Yamaguchi Prefecture◯ Nariaki Ougiya, Satoshi Fukushima, Atsuto Onoda, Ken Takeda, Ken Tachibana(Fac Pharma. Sanyo-Onoda City Univ.)

P-106

Effects of Fetal Exposure to Ultrafine Particles on Brain Development in a Modelof Setd5 Deficiency◯ Risa Fuku, Atsuto Onoda, Tadashi Nakagawa, Ken Tachibana, Ken Takeda(Fac. Pharm. Sanyo- Onoda city Univ.)

P-107

Analysis of polycyclic aromatic hydrocarbon quinones in atmospheric fineparticulate matter (PM2.5) collected in Wajima, Ishikawa◯ Ayaka Furukawa1, Sakura Yoshida1, Yumi Abiko1, Ning Tang2, Akira Toriba1(1 Grad. Sch. Bio. Sci., Nagasaki Univ, 2Institute of Nature and Environmental
Technology, Kanazawa Univ.)−80−P-108Analysis of quinoid polycyclic aromatic hydrocarbons in the mainstream smoke ofelectronic cigarettes◯ Hibiki Yoshioka1, Sakura Yoshida1, Yumi Abiko1, Kanae Bekki2, Yohei Inaba2,
Akira Toriba1(1Grad. Sch. Biomed. Sci., Nagasaki Univ., 2National Institute of Public Health)P-109

Role of human selenium-binding protein 1 in lipid metabolism with HepG2◯ Shuangli Zhao1, Yuko Nakashima1, Yingxia Song1, Ren-shi Li2, Takayuki Koga3,
Yoshitaka Tanaka1, Yuji Ishii1(1Kyushu Univ., 2China Pharmaceutical University, 3Daiichi Univ. Pharmacy)

P-110

Residual profile and human exposure of brominated and chlorinated chemicals incrustacean products from Asian market◯ Katsumi Kodo1, Yukiko Fujii1, Yoshihisa Kato2, Junpei Ando1, Keiko Murayama1,
Koichi Haraguchi1(1Fac. Pharm. Sci., Daiichi Univ. Pharm., 2Kagawa Pharm. Sci., Tokushima Bunri Univ.)

P-111

Detection of estrogenic activity at low doses of bisphenol A using highly sensitive in
vivo screening method◯ Keishi Ishida1, Motoshi Furukawa1, Masataka Kunitani1, Rai Yamagiwa1,
Youhei Hiromori1,2, Daisuke Matsumaru1, Jianying Hu3, Hisamitsu Nagase4,
and Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Suzuka Med. Sci. Univ., 3Peking Univ., 4Gifu Univ. of Med. Sci.,)

P-112

Thyroid hormone (TH) promotes urinary excretion of 2,3,7,8-tetrachlorodibenzop -dioxin (TCDD) via the function of TH receptor (TR) β in mice
◯ Shunsuke Tomita1, Pinyapach Dungkokkruad2, Youhei Hiromori3, Keishi Ishida1,
Daisuke Matsumaru1, Hisamitsu Nagase4, and Tsuyoshi Nakanishi1(1 Gifu Pharm. Univ., 2 Mahasarakham Univ., 3 Suzuka Univ. of Med. Sci., 4 Gifu Univ.
of Med. Sci.)

P-113

Investigation of the effects of PPCPs on plant seed germination and growth
Ryo Ujihara, Reiji Sadamatsu, Taro Imura, Youki Miyano, Ryosuke Tarumoto,Ryo Shimizu, ○ Kazumi Sugihara(Faculty of Pharmaceutical Sciences, Hiroshima International University)

P-114

Physical property analysis of silver nanoparticles after oral exposure◯ Kazuya Nagano1,2, Ikkei Tasaki1, Yasuo Tsutsumi2(1Sch. Pharm. Sci., Wakayama Med. Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.)−81−P-115

Green algae Chlamydomonas reinhardtii acquire adaptability to copper stress bydefense and tolerance/recovery responses◯ Ryotaro Tsutsumi1, Risa Yoshimoto2, Jiro Miura3, Takuya Yamashita1,
Kazumasa Hirata1,2, Kazuya Nagano1,2(1Sch. Pharm. Sci., Wakayama Medical Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.,
3
Grad. Sch. Dent. Sci., Osaka Univ.)

P-116

Investigation of mechanism of impaired proximal tubular reabsorption by
injection of cadmium-metallothionein Complex◯ Hitomi Fujishiro1, Kanako Matsumoto1, Yuka Ishizaki1, Kumiko Takeuchi1,
Miku Takahashi1, Seiichiro Himeno2, Daigo Sumi1(1Fac. Pharm. Sci., Tokushima Bunri Univ, 2 Fac. Pharm., Showa Univ.)

P-117

Fundamental investigation of heavy metal adsorption using mangosteen shell forthe improvement of water environment◯ Yugo Uematsu, Ibuki Kobata, Fumihiko Ogata, Naohito Kawasaki(Fac. Pharm., Kindai Univ.)

P-118

Alterations in protein polysulfidation induced by methylmercury exposure◯ Takamitsu Unoki1, Masahiro Akiyama2, Yoshito Kumagai3, Masatake Fujimura1(1Dept. Basic Med. Sci., Nat. Inst. Minamata Dis., 2Fac. Pharm., Keio Univ., 3Grad. Sch.
Pharm. Sci., Kyushu Univ.)

P-119

Cadmium accumulation in invasive function-impaired extravillous trophoblastlike HTR-8/SVneo cells◯ Shoko Ogushi1, Hitomi Fujishiro2, Tsuyoshi Nakanishi3 Tomoki Kimura1(1 Fac. Pharm. Sci., Setsunan Univ., 2 Fac. Pharm. Sci., Tokushima Bunri Univ., 3Gifu
Pharm. Univ.)

P-120

Green tea catechin promotes recovery of endothelial barrier◯ Rio Wakasugi1, Saki Ishii 1, Koichi Uemura2, Kenji Suzuki1,2,
Takako Kaneko-Kawano 1,2(1Col. Pharm. Sci., Ritsumeikan Univ., 2 Grad. Sch. Pharm., Ritsumeikan Univ.)

P-121

The suppressing effects of luteolin on the cholesterol absorption mechanism via
NPC1L1
Tomoya Hanayama1, Kaito Agari1, Masayo Hirao-Suzuki2, Shuso Takeda1,
Jun Kamishikiryo, 〇 Narumi Sugihara1(1Fac. Pharm. Pharmaceut. Sci., Fukuyama Unov., 2Fac. Pharm. Sci., Hiroshima Intl.
Univ.)−82−

P-122

Effect of epithelial-mesenchymal transition-associated anticancer drugs on theepithelial and mesenchymal phenotypes in non-small lung cell cancer cells◯ Ryo Takahashi1, Masashi Kawami1, Ryoko Yumoto1, Mikihisa Takano2,
Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. Pharm. Sci., Yasuda
Women Univ.)

P-123

Novel approach to identify miRNAs involved in drug-induced EMT by RNAsequence analysis◯ Yuki Maeda1, Masashi Kawami1, Ryoko Yumoto1, Mikihisa Takano2, Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. Pharm. Sci., Yasuda
Women Univ.)

P-124

Alleviation effect of Contact Dermatitis by the Glycation Product Dihydropyrazine◯ Madoka Sawai1, Yutaka Tatano1, Jian-Rong Zhou2, Shunji Itoh3, Masaki Yoshida4,
Yuu Miyauchi2, Shinji Takechi2(1Sch. Pharm., at Fukuoka. Int. Univ. Health & Welfare., 2 Fac. Pharmaceut. Sci., Sojo
Univ., 3Dept. Health Sci., Grad. Sch. Health Sci., Kansai Univ. Health Sci., 4Sch. Biosci.
Biotech., TUT.)

P-125

Thrombin-cleaved nephronectin is involved in experimental autoimmune
encephalomyelitis (EAE) through a novel cell adhesion mechanism◯ Machiko Honda, Shigeyuki Kon(Fac. of Pharm. Sci., Fukuyama Univ.)

P-126

Characteristic analysis of extracellular vesicles derived from the serum of fish to
elucidate the mechanism of human health by fish intake◯ Takuya Yamashita1, Ryotaro Tsutsumi1, Kazuya Nagano1,2(1Sch. Pharm. Sci., Wakayama Med. Univ., 2Grad. Sch. Pharm. Sci., Osaka Univ.)

P-127

Serotonin release from QGP-1 cells, an enterochromaffin cell model, by ahydrolysis product of di-2-ethylhexyl phthalate◯ Ryuto Yuasa1, Yoko Mori1,2, Tamaki Azuma1, Akira Aoki1, Yoshinori Okamoto1,
Takashi Isobe3, Susumu Ohkawara3, Nobumitsu Hanioka3, Toshiko Tanaka-Kagawa3,and Hideto Jinno1(1 Faculty of Pharmacy, Meijo University, 2 National Institute of Environmental Studies,3
Yokohama University of Pharmacy)

P-128

Investigation of the molecular mechanism of the transcriptional regulation of
GADD45β by the xenoresponsive nuclear receptor CAR◯ Aki Takeshita, Ryota Shizu, Natsuki Makida, Takuomi Hosaka, Kouichi Yoshinari(Sch. Pharm. Sci., Univ. Shizuoka)−83−P-129Effects of HMG-CoA reductase inhibitors on T cell-immune responses◯ Kanon Murase, Satoshi Ishikawa, Saotomo Itoh, Shigeaki Hida
(Fac. Pharm. Sci., Nagoya City Univ.)

P-130

Role of transcription factor IRF2 in innate immunity◯ Tomoki Nagai1, Iduru Ikuta1,Syungo Sasaki1, Yuma Ito1, Saotomo Ito1,
Shinsuke Taki2, Shigeaki Hida1(1Fac. Pharm. Sci., Nagoya City Univ, 2 Shinshu Univ.)

P-131

Effects of hypoxia and low glucose on the Neuroserpin expression levels of SHSY5Y cells◯ Yuriko Takahashi, Atsuto Onoda, Ken Tachibana, Ken Takeda(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-132

Targeting cellular gaps using asymmetrical (Janus) nanoparticles in Caco-2 cells◯ Takeo Kitazawa1, Akihiro Matsumoto2, Yuta Hatori1, Mikihisa Takano1,
Chie Watanabe3, Tomoya Takashima2, Masahiro Murakami2(1Fac. Pharm., Yasuda Women's Univ, 2Fac. Pharm., Osaka Ohtani Univ, 3Fac. Pharm.,Josai Univ.)

P-133

Exploration of candidate drugs to induce metallothionein 3◯ Mizuki Tsuru1, Kazuki Komai1, Kazuki Ohuchi1, Yasuhiro Shinkai2,
Tomoki Kimura3, Nobuhiko Miura4, Yoshito Kumagai5, Isao Hozumi1,
Masatoshi Inden1, Hisaka Kurita1(1Fac. Pharm. Sci., Gifu Pharmaceutical Univ, 2Sch. Life Sci., Tokyo Univ. Pharm. andLife Sci., 3Fac. Pharm. Sci., Setsunan Univ, 4Fac. Pharm. Sci., Yokohama Univ. Pharma,
5
Fac. Pharm. Sci., Kyushu Univ.)

P-134

Investigation of the mechanism of insolubilization of intralysosomal hydrolases
induced by the lysosomal membrane-damaging agent LLOMe◯ Natsumi Fujiwara1, Masatsugu Miyara1, Ayaka Yabuki1, Kanae Miyara2,
Yaichiro Kotake1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2JSPS Research Fellow
RPD.)

P-135

Discovery of p62 nuclear accumulation induced by a Parkinson's disease-related
neurotoxin and a novel nuclear role of p62◯ Honoka Hashimoto1, Masatsugu Miyara1, Yuka Kuwabara1, Hiroki Tsumoto2,
Yuri Miura2, Yaichiro Kotake1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Tokyo Metropolitan
Institute for Geriatrics and Gerontology)−84−

P-136

Molecular mechanisms of ferroptosis induced by conjugated fatty acids◯ Yusuke Hirata, Yuto Yamada, Takuya Noguchi, and Atsushi Matsuzawa(Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

P-137

Association of doxorubicin-induced epithelial-mesenchymal transition with theanticancer effect in A549 cells◯ Sora Fujimoto1, Masashi Kawami1, Ryoko Yumoto1, Mikihisa Takano2,
Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. Pharm. Sci., Yasuda
Women Univ.)

P-138

Functional analysis of soluble epoxide hydrolase in lipid metabolism in the brain◯ Ami Oguro1 Shinji Fujimoto2, Yasuhiro Ishihara3 Takeshi Yamazaki3,
Yaichiro Kotake1(1Grad. Sch. of Biomed. and Health Sci, Hiroshima Univ., 3Pharm. Sci., Hiroshima
Univ. 3Grad. Sch of Integrated Sci. for Life, Hiroshima Univ.)

P-139

Rotenone treatment enhances type I interferon production in BV2 microglial cellline
◯ Yoki Nakamura, Manaya Nakano, Momoka Iwamoto, Kazue Hisaoka-Nakashima,
Norimitsu Morioka(Dept. Pharmacol., Grad. Sch. Biomed. Health Sci., Hiroshima Univ.)

P-140

Effect of furosemide to the expression of ion transporters on brain in neonatal
chronic lung disease◯ Hiroki Kurokawa1, Atsuto Onoda1,2, Yoshiaki Sato2, Xu Yue2,3, Ken Tachibana1,
Ken Takeda1(1Dep. Pharm., Sanyo-Onoda City Univ, 2Cent. Mat-Neo., Nagoya Univ. Hosp. 3Grad.
Med., Nagoya)

P-141

Development of a read-across method for evaluating developmental neurotoxicity
using molecular descriptors◯ Manaya Takamura1, Nao Omura1, Takuomi Hosaka1, Ryota Shizu1,
Jun-ichi Takeshita2, Kouichi Yoshinari1(1Sch. Pharm. Sci., Univ. Shizuoka, 2National Institute of Advanced Industrial Scienceand Technology)

P-142

The effect of endotoxin contained in PM2.5 on the prognosis of cerebral infarction◯ Naoyuki Nezu1, Miki Tanaka1, Tomoaki Okuda2, Yasuhiro Ishihara1(1Integrated Sciences for life, Hiroshima Univ, 2Faculty of Science and Engineering,
Keio Univ.)−85−

P-143

In utero exposure to the antiepileptic drug valproic acid induces a long-lasting
hyperalgesia and allodynia associated with central sensitization◯ Takeru Tahara1, Eiji Imado1, Daisuke Uta2, Satoshi Asano1, Kazuhiro Takuma3,
Toshiaki Kume2, Yaichiro Kotake1, Yukio Ago1
(1Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2Grad. Sch. Med. Pharm. Sci., Univ.
Toyama, 3Grad. Sch. Dent., Osaka Univ.)

P-144

Differential response of hindbrain astrocytes upon excess ethanol administration inmice◯ Hiroshi Hasegawa, Mari Kondo, Kei Nakayama(Kobe Pharm. Univ.)

P-145

Analysis of epigenetic alteration in SYP and DLG4 genes induced by exposure to
low concentrations of methylmercury during neuronal differentiation◯ Hisaka Kurita, Haruka Masuda, Ayu Okuda, Kazuki Ohuchi, Isao Hozumi,
Masatoshi Inden(Fac. Pharm. Sci., Gifu Pharm Univ.)

P-146

Search for genes involved in susceptibility to Parkinson's disease-associatedneurotoxin MPP ＋◯ Futa Suzuki, Masatsugu Miyara, Yaichiro Kotake(Grad. Sch. of Biomed. Health Sci., Hiroshima Univ.)

P-147

The relationship between maternal thyroid-related parameters and brain
development in offspring under chemical-induced hypothyroidism◯ Manami Koizumi1, Keishi Ishida1, Saori Kasuya1, Kanoko Tatsumi1,
Kyoko Mekada1, Daisuke Matsumaru1, Aki Murashima1, Hisamitsu Nagase2,
Yasunari Kanda3, Kazuhiro Takuma4, Tsuyoshi Nakanishi1(1Gifu Pharm. Univ., 2Gifu Uni. of Med Sci., 3NIHS, 4Osaka Univ.)

P-148

Prenatal VPA exposure impairs myelination and increases chemotaxis of
Oligodendrocyte Precursor Cells◯ Sakuno Nishimura1, Kouichi Itoh2, Yasuhiro Ishihara1(1Grad. Sch. Integ. Sci for Life, Biomed, Hiroshima Univ, 2Fac. Kagawa-Phar.
Therapeutic phar., Tokushima-bunri Univ.)−86−P-149Assessment of SARS-CoV-2-infected blood brain barrier dysfunction using human
iPSC-derived brain microvascular endothelial-like cells◯ Shota Yanagida1,2,3, Shigeru Yamada1, Tadahiro Hashita4, Hiroyuki Sato4,
Yukuto Yasuhiko1, Kaori Okabe5, Takamasa Noda5, Motohiro Nishida6,7,
Tamihide Matsunaga4, Yasunari Kanda1(1Div. Pharmacol., NIHS, 2 Grad. Sch. Pharma. Sci., Hiroshima Univ., 3PD, JSPS,
4
Grad. Sch. Pharma. Sci., Nagoya City Univ., 5 NCNP Hospital, 6Grad. Sch. Pharma.
Sci., Kyushu Univ., 7 NIPS)

P-150

Effects of Metallothionein Knockout on Differentiation of C2C12 Myoblasts into
Myotubes◯ Yoshito Kadota, Takashige Kawakami, Shinya Suzuki(Fac. Pharm. Sci., Tokushima Bunri Univ.)

P-151

Dihydropyrazines induce endoplasmic reticulum stress and inhibit autophagy◯ Shinji Takechi1, Madoka Sawai2, Yuu Miyauchi1(1Fac. Pharmaceut. Sci., Sojo Univ., 2Sch. Pharm., at Fukuoka. Int. Univ. Health &Welfare.)P-152

The reversibility of electrophilic modification on PTP1B-bound polysulfides
reactive sulfur species◯ Yumi Abiko1, Sakura Yoshida1, Akira Toriba1, Yoshito Kumagai2(1Grad. Sch. Bio. Sci., Nagasaki Univ, 2 Fac. Med., Univ. Tsukuba.)

P-153

Effect of neonicotinoid insecticides and their metabolites on the gene expression
profile of mouse neural stem cells◯ Tomomi Mikajiri, Atsuto Onoda, Ken Takeda, Ken Tachibana(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-154

Identification of toxicologically important findings in rat repeated-dose toxicity
studies of pesticides◯ Hiroaki Suzuki, Yu Harakawa, Manaya Takamura, Kosuke Mizuno,
Takuomi Hosaka, Ryota Shizu, Kouichi Yoshinari(Sch. Pharm. Sci., Univ Shizuoka)

P-155

Chemical structures and cytotoxic activities of the constituents isolated from
Citrus hassaku◯ Takuya Muraoka, Daisuke Imahori, Rina Miyagi, Hiroyuki Tanaka(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)−87−

P-156

Chemical structure and cytotoxic activities of constituents isolated from the peelsof Citrus sphaerocarpa◯ Daisuke Imahori, Takuya Muraoka, Rina Miyagi, Hiroyuki Tanaka(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-157

Regulation of hepatic Adig expression by PPARγ◯ Daisuke Aibara, Asuka Nakano, Funo Hashimoto, Ai Sakaguchi, Kohei Matsuo,
Kimihiko Matsusue(Faculty of Pharmaceutical Science, Fukuoka University)

P-158

Global analysis of extracellular/intracellular metabolites from exogenous
lysophospholipids in HT-29, human colon cancer-derived epithelial cell line
◯ Yuya Ohtsuki, Kohei Kawabata, Erena Nakamura, Moe Asakami, Reina Morikawa,
Hiroyuki Nishi, Akira Tokumura(Fac. Pharm., Yasuda Womenʼs Univ)

P-159

Cannabidiolic acid induces the expression of ANGPTL4, a PPARβ/δ target gene, in
MDA-MB-231 cells
Masayo Hirao-Suzuki1, Koki Kanameda2, Takayuki Koga3, Masufumi Takiguchi1,
Narumi Sugihara2, ◯ Shuso Takeda2(1Fac. Pharm. Sci., Hiroshima Intl. Univ., 2Fac. Pharm. Pharmaceut. Sci., Fukuyama
Univ., 3Daiichi Univ. Pharm.)

P-160

Function of STAT3β, minor type splicing isoform, in adipogenic differentiation◯ Yuika Morita1, Kenji Suzuki1,2, So Masaki2(1Grad. Sch. Pharm., Ritsumeikan Univ, 2Col. Pharmaceut. Sci., Ritsumeikan Univ.)

P-161

Effect of monocarboxylate transporters on the inhibitory action of ketone body on
cancer cell proliferation◯ Ami Tanaka1, Marina Takahashi1, Maika Nakagawa1, Tomoka Kendai1,
Chihiro Nakamura1, So Masaki1, Noriko Takahashi2, Kenji Suzuki1(1Dep. of Pharm. Sci., Ritsumeikan Univ., 2Inst. of Medic. Chem., Hoshi Univ.)

P-162

The contribution of Selenium binding protein 1 (Selenbp1) to the regulation ofhepatic methionine metabolizing enzyme Bhmt expression based on skin-liverinteraction by allergic contact dermatitis◯ Takayuki Koga1, Makoto Hiromura1, Masayo Hirao-Suzuki2, Shuso Takeda3,
Yuji Ishii4, Takumi Ishida5, Yukiko Fujii1, Yuko Kobuke1, Akihisa Toda1, Fumio Soeda1(1Daiichi Univ. Pharm., 2Fac. Pharm. Sci., Hiroshima Intl. Univ., 3Fac. Pharm. Sci.,
Fukuyama Univ., 4Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 5Sch. Pharm. Fukuoka,
Int. Univ. Health & Welfare)−88−P-163

Selenium binding protein 1 (Selenbp1) deficiency reduces fatty liver induced byhigh-fat diet
◯ Takayuki Koga1, Makoto Hiromura1, Syota Kagawa1, Masayo Hirao-Suzuki2,
Shuso Takeda3, Yuji Ishii4, Takumi Ishida5, Fumihiro Nagashima1, Yukiko Fujii1,
Yuko Kobuke1, Akihisa Toda1, Fumio Soeda1(1Daiichi Univ. Pharm., 2Fac. Pharm. Sci., Hiroshima Intl. Univ., 3Fac. Pharm. Sci.,
Fukuyama Univ., 4Grad. Sch. Pharmaceut. Sci., Kyushu Univ., 5Sch. Pharm. Fukuoka,
Int. Univ. Health & Welfare)

P-164

Functional analysis of vitamin K converting enzyme UBIAD1 in bone formation◯ Shunsuke Hirashima1, Yukino Kiyooka2, Shinichiro Kaetsu2, Kimie Nakagawa1,2(1 Grad. Sch. Pharm. Sci., Kobegakuin Univ, 2 Fac. Pharm. Sci., Kobegakuin Univ.)

P-165

PXR-dependent inhibition of the proliferation of ERα-positive breast cancer cells◯ Kazuki Ota, Takuomi Hosaka, Aoi Yoshihara, Ryota Shizu, Yuichiro Kanno,
Kouichi Yoshinari(Sch. Pharm. Sci., Univ. Shizuoka)

P-166

Functional analysis of vitamin K-converting enzyme (UBIAD1) in adipose tissue
using Tamoxifen-inducible gene-deficient mice
◯ Rika Horigome1, Momoka Nagura1, Haruka Saeki1, Shunsuke Hirashima2,
Kimie Nakagawa1,2(1Fac. Pharm. Sci., Kobe Gakuin Univ, 2Grad. Sch. Pharm. Sci., Kobe Gakuin Univ.)

P-167

Structural characterization of HMG-CoA reductase and menadione analogues that
regulate the activity of vitamin K-converting enzyme UBIAD1◯ Akihiro Endo1, Ami Hamade1, Yuina Nakagami1, Yoshiaki Nishino1,
Shunsuke Hirashima2, Kimie Nakagawa1.2(1Fac. Pharm. Sci., Kobe Gakuin Univ, 2Grad. Sch. Pharm. Sci., Kobe Gakuin Univ.)

P-168

Morphinone, an electrophilic metabolite of morphine, activates the electrophilic
signaling of the AKT/CREB pathway via phosphorylation in human hepatoma
HepG2 cells◯ Kohei Matsuo, Ai Sakaguchi, Daisuke Aibara, Kimihiko Matsusue(Fac. Pharmaceut. Sci., Fukuoka. Univ.)

P-169

Expression profiles of aldehyde-metabolizing enzymes and metabolic activities ofvolatile aldehydes in mouse olfactory epithelium◯ Naoki Takaoka1,2, Seigo Sanoh1,2, Yaichiro Kotake2, Mami Kurosaki3, Mineko Terao3,
Enrico Garattini3, Shigeru Ohta1,2(1Sch. Pharm. Sci., Wakayama Med. Univ., 2Grad. Sch. Biomed. Health Sci., Hiroshima
Univ., 3Institute di Ricerche Farmacologie Mario Negri)−89−P-170Effects of acute hepatitis on phenobarbital-induced cytochrome P450 expression inmice◯ Yukine Kubo, Chieri Fujino, Satoshi Ueshima, Toshiya Katsura(College of Pharmaceutical Sciences, Ritsumeikan University)

P-171

Decrease of endotoxin in rice by polishing and germinating◯ Mai Hiramoto1, Nana Miyazaki1, Akihiro Kameda2, Yuya Deguchi1,
Hiroaki Nagaoka1(1Fac. Pharm. Sci., Nagasaki Intl. Univ., 2Hatsugagenmai Co., Ltd.)

P-172

Effect of Food Thickeners on the Disintegration of Tablets◯ Shion Matsuda, Kana Mitsuyasu, Seitaro Kamiya, Yuya Deguchi, Hiroaki Nagaoka(Fac. Pharm. Sci., Nagasaki Intl. Univ.)

P-173

Effect of fetal growth restriction on brain development: Expression levels of OX2
glycoprotein in oligodendrocytes◯ Ayumi Yamato, Atsuto Onoda, Ken Tachibana, Ken Takeda(Fac. Pharm. Sci., Sanyo-Onoda City Univ.)

P-174

Inhibitory effect of sulfated vizantin on LPS-induced TNF-α production◯ Takashige Kawakami, Managi Namikawa, Hirofumi Yamamoto, Tomomi Abe,
Yoshito Kadota, Shinya Suzuki, Masahisa Inoue(Faculty of Pharmaceutical Sciences, Tokushima Bunri University)

P-175

Exploring the mechanism of enrichment effect on micturition function in druginduced menopausal model mice
◯ Fumio Soeda, Mayo Kubota, Kiho Ichinomiya, Ryo Yokoo, Tatsuya Oda,
Takayuki Koga, Yuko Kobuke(Daiichi Univ. Pharm.)

P-176

Inhibitory effect of dexamethasone on the function of peptide transporter 2 inalveolar epithelial cells◯ Miku Matsuoka1, Masashi Kawami1, Ryoko Yumoto1, Mikihisa Takano2,
Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. Pharm. Sci., Yasuda
Women Univ.)

P-177

Transport mechanism of nicotine focusing on intracellular pH in cultured cell lines◯ Nozomi Hakotani1, Masashi Kawami1, Ryoko Yumoto1, Mikihisa Takano2,
Yasuo Uchida1(1Grad. Sch. of Biomed. and Health Sci., Hiroshima Univ., 2Fac. Pharm. Sci., Yasuda
Women Univ.)−90−P-178The selective androgen receptor modulator YK11 regulates binding oftranscriptional coactivators through NTD and AF2 interactions in androgen
receptor◯ Tomohiro Kosuge, Ryota Shizu, Takuomi Hosaka, Yuichiro Kanno,
Kouichi Yoshinari(Sch. Pharm. Sci, Univ. Shizuoka)−91−