↢๮⑼ቇ✚ว⎇ⓥᡰេ࠮ࡦ࠲࡯ ህ᳇ᕈ⩶⎇ⓥಽ㊁1㧚⎇ⓥߩ᭎ⷐ
 ᒰಽ㊁ߢߪ‫⥃ޔ‬ᐥᓸ↢‛ቇߩ┙႐߆ࠄ‫ޔ‬ህ᳇ᕈ⩶࡮ህ᳇ᕈ⩶ᗵᨴ∝ߦ㑐ߔࠆၮ␆⊛࡮⥃ᐥ⊛⎇ⓥࠍ
ㅴ߼ߡ޿ࠆ‫ౕޕ‬૕⊛ߦߪ⎕்㘑‫ࠬࠟޔ‬უ∓‫ߤߥ∝ࠬ࠿࡝࠷ࡏޔ‬Ქ⚛↥↢ᕈߩህ᳇ᕈ⩶ߦࠃࠆᄖ࿃ᕈߩ
ᗵᨴ∝‫ⴚߦ߽߅ޔ‬ᓟߦ⷗ࠄࠇࠆህ᳇ᕈ⩶ߣㅢᕈ⩶߇⋧ਸ਼⊛ߦ∛ේᕈࠍ⊒ើߔࠆౝ࿃ᕈߩⶄᢙ⩶ᗵᨴ∝‫ޔ‬⧘⢩ࠍ߽ߟህ᳇ᕈ⩶ߦࠃࠆ㒮ౝᗵᨴ∝ߥߤߩህ᳇ᕈ⩶߇㑐ଥߔࠆᄙ⒳ᄙ᭽ߩᗵᨴ∝ߩ⸻ᢿ‫ޔ‬ᴦ≮‫ߘޔ‬ߒߡ੍㒐ߦᓎߛߟࠃ߁ߥ⎇ⓥࠍ⚦⩶ቇ⊛ߥ┙႐߆ࠄⴕߞߡ޿ࠆ‫ޕ‬ህ᳇ᕈ⩶ߩಽ㔌ၭ㙃หቯᴺߩᡷ⦟‫ޔ‬
ህ᳇ᕈ⩶ߩ∛ේ࿃ሶ‫ޔ‬ህ᳇ᕈ⩶ߩ᛫⩶⮎ᗵฃᕈߩ᷹ቯߣߘߩ᷹ቯᴺߩᡷ⦟‫ޔ‬᛫ህ᳇ᕈ⩶૞↪ࠍ᦭ߔࠆ‛⾰ߩត⚝ߣߘࠇࠄߩ᛫⩶ജߩ⹏ଔ‫ޔ‬ህ᳇ᕈ⩶ߩ᛫⩶⮎ߦኻߔࠆ⠴ᕈ⃻⽎ߩ⸃᣿‫ޔߡߒߘޔ‬ህ᳇ᕈ⩶߇ఝ൓ߥࡅ࠻࿕᦭⚦⩶ฌߩ⇣Ᏹൻ߇ේ࿃ߣߥߞߡ߅ߎࠆ⒳‫ ޟߩޘ‬਎♿∛‫⎇ߩߡ޿ߟߦޠ‬ⓥߥߤࠍዷ㐿ߒߡ޿ࠆ‫ޕ‬2㧚ฬ★
ᢎ᝼㧦ᷰㆺ㇌෹ಎᢎ᝼㧦↰ਛ㚅߅㉿ഥᢎ㧦ᓟ⮮㓉ᰴ⎇ⓥ⵬ഥຬ㧦 ਛᎹᦶሶKunitomo Watanabe
Kaori TanakaTakatsugu Goto
Akiko Nakagawa

3㧚⎇ⓥᚑᨐߩ⊒⴫⪺ᦠ㧔๺ᢥ㧕1㧕ᷰㆺ㇌෹‫ޔ‬㜞ਭਭ㤚⋙ୃ‫ޔ‬ᗵᨴ∝ᬌᩏ ᗵᨴ∝ㆮવሶᬌᩏ 㩂㩥㩇㩎㩢㩆㩨㨽㩛㨯㩍㩨㨲㩖㨲㩆㩤ㆮવሶᬌᩏ ᓸ↢‛↥↢‛࡮ઍ⻢↥‛ ࡏ࠷࡝࠿ࠬᲥ⚛‫ޔ‬CD ࠻ࠠࠪࡦ‫ࡦࡒࠬࡄࠬࡁ࠲࠹ޔ‬㧦⥃ᐥᬌᩏ࠺࡯࠲ࡉ࠶ࠢ
2009-2010 ᧲੩ කቇᦠ㒮 2009 ᐕ:491-492㧘524-528
2㧕ᷰㆺ㇌෹‫ޔ‬㜞ਭਭ㤚࡮የᒻᖝ㇢࡮㤥Ꮉᷡ࡮⍫ፒ⟵㓶⋙ୃ‫ ޔ‬㧱㧚ህ᳇ᕈ⩶ᗵᨴ∝ 㧝㧚⎕்㘑㧘㧞㧚ࠟࠬუ∓‫ޔ‬㧟㧚ή⧘⢩ህ᳇ᕈ⩶߇㑐ਈߔࠆⶄᢙ⩶ᗵᨴ∝ ᣂ⥃ᐥౝ⑼ቇ ╙㧥  කቇᦠ㒮 ᧲੩ 2009 ᐕ:1333-13353㧕ᷰㆺ㇌෹‫⑔ޔ‬੗ᰴ⍫࡮㤥Ꮉᷡᣣᧄ⺆ ⋙ୃ‫ ޔ‬Part7 ᗵᨴ∝ Section7 ߘߩઁߩ⚦⩶ᗵᨴ∝ 157.
ህ᳇ᕈ⩶ࠍ฽߻ⶄᢙ⩶ᗵᨴ∝ ࡂ࡝࠰ࡦౝ⑼ቇ╙㧟  㧝Ꮞ ᄢ㒋ࡔ࠺ࠖࠞ࡞ࠨࠗࠛࡦࠬࠗࡦ࠲࡯࠽࡚ࠪ࠽࡞ 2009 ᐕ:1046-1054✚⺑1) ᷰㆺ㇌෹. ஍ᕈህ᳇ᕈ⩶ᗵᨴ∝ߩၮ␆ߣ⥃ᐥ̆஍ᕈህ᳇ᕈ⩶ߩಽ㘃 ⥃ᐥߣᓸ↢‛.
2008:35(4):21-28.
2) Nagayama A, Yamaguchi K, Watanabe K, Tanaka M, Kobayashi I, Nagasawa Z. Final reportfrom thecommittee on Antimicrobial Susceptibility Testing, Japanese Society of Chemotherapy,
on the agar dilution method (2007). J Infect Chemother 2008:14:383-392.

ේ⪺1) ↰ਛ㚅߅㉿‫ޔ‬ᷰㆺ㇌෹. Tebipenem ߩህ᳇ᕈ⩶ߦኻߔࠆ in vitro ᛫⩶૞↪‫ޔ‬ᣣᧄൻቇ≮ᴺቇળ㔀
⹹. 2009 ᐕ:57(S-1):30-37.
2) ⍹㤥ථ‫ޔ‬㜞ᩉ᣹‫↰ޔ‬ਛ㚅߅㉿‫৻⚔↰☨ޔ‬㇢‫ޔ⵨↰᧖ޔ‬ᷰㆺ㇌෹. Capnocytophaga ߣ Actinomycesisraelii ߦࠃࠆ⤥⢷ߩ㧝଀, ᣣᧄ๭ๆེቇ㔀⹹. 2009 ᐕ:47(10):906-911.
3) Tanaka K, Mikamo H, Nakao K, Ichiishi T, Goto T, Yamagishi Y, Watanabe K. In vitro activityof tomopenem (CS-023/RO4908463) against anaerobic bacteria. Antimicrob Agents Chemother.
2009:53:319-322.
4) Sugisaki H, Yamanaka K, Kakeda M, Kitagawa H, Tanaka K, Watanabe K, Gabazza EC,Kurokawa I, Mizutani H. Increased interferon-gamma, interleukin-12p40, and IL 8 productionin Propionibacterium acnes-treated perioheral blood mononuclear cells from patients withacne vulgaris: host response but not bacterial species is the determinant factor of the diseases.
J Dermatol Sci. 2009:55(1):47-52.

 ̆1̆5) Furukawa A, Uchida K, Ishige Y, Ishige I, Kobayashi I, Takemura T, Yokoyama T, Iwai K,Watanabe K, Shimizu S, Ishida N, Suzuki Y, Suzuki T, Yamada T, Ito T, Eishi Y.
Characterization of Propionibacterium acnes isolates from sarcoidosis and non-sarcoidosis
tissues with special reference to cell invasiveness, serotype, and trigger factor gene
polymorphism. Microb Pathog. 2009:46(2):80-87.
6) Sawada A, Mochizuki K, KatadaT, Kawakami H, Yamamoto T, Mikamo H, Watanabe K.
Gemella species-associated late-onset endophthalmitis after trabeculectomy with adjunctive
mitomycin C. J Glaucoma. 2009:18(69):496-497.
7) Oyama T, Yasui Y, Sugie S, M Koketsu, Watanabe K, Tanaka T. Dietary tricin suppress
inflammation-related colon carcinogenesis in male Crj: CD-1 mice. Cancer Prev Res. 2009:2(12):1031-1038.
8) Nakao K, Tanaka K, Ichiishi S, Mikamo H, Shibata T, Watanabe K. Susceptibilities of 23
Desulfovbrio isolates from humans. Antimicrob Agents Chemother. 2009:53(12):5308-5311.

ቇળ‫ޣ‬࿖㓙ቇળ‫ޤ‬1) Tanaka K, Mikamo H, Takesue Y, Yokoyama T, Shinagawa N, Watanabe K. A study onbacteria isolated from intra-abdominal infections in Japan and their antimicrobial
susceptibility. 19th European Society of Clinical Microbiology and Infectious Diseases,Helsinki, Finland, 2009.5.16-19.
2) Yamagishi Y, Tanaka K, Watanabe K, Mikamo H. Clinical implications of drug resistantanaerobes in respiratory tract infections and intra-abdominal infections. 26thInternational Congress of Chemotherapy and Infection. Tront, Canada, 2009.6.18-21.
‫ޣ‬࿖ౝቇળ࡮⎇ⓥળ৻⥸Ṷ㗴‫ޤ‬1) Ꮢ⍹ථ‫ޔ‬ખየ⾫৻‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ᓟ⮮㓉ᰴ‫ޔ‬ਃ㡞ᑝ❥‫ޔ‬ᷰㆺ㇌෹㧦ࡅ࠻↱᧪ Desulfovibrio spp.
ߩหቯᴺߦ㑐ߔࠆᬌ⸛‫ ╙ޔ‬82 ࿁ᣣᧄ⚦⩶ቇળ‫ޔ‬ฬฎደ‫ޔ‬2009.3.12-14.
2) Ꮢ⍹ථ‫ޔ‬ખየ⾫৻‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ਃ㡞ᑝ❥‫ޔ‬ᷰㆺ㇌෹㧦Desulfovibrio spp.ߩ⮎೷ᗵฃᕈ‫╙ޔ‬
12 ࿁ᣣᧄ⥃ᐥ⣺ౝᓸ↢‛ቇળ✚ળ‫ޔ‬ጘ㒂‫ޔ‬2009.9.5.
3) Ꮢ⍹ථ‫↰ޔ‬ਛ㚅߅㉿‫ޔ‬ਃ㡞ᑝ❥‫ޔ‬ᷰㆺ㇌෹㧦ၭ㙃ᴺߦࠃࠆ⤖߆ࠄߩ H2S ↥↢⩶㧔⎫㉄ㆶర⚦⩶㧕ߩಽ㔌‫ ╙ޔ‬46 ࿁ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ✚ળ‫ޔ‬ฬฎደ‫ޔ‬2009.10.23-24.
‫ޣ‬࿖ౝቇળ࡮⎇ⓥળ᜗ᓙ⻠Ṷ‫ޤ‬1㧕 ↰ਛ㚅߅㉿㧦ᢎ⢒⻠Ṷ‫ޟ‬ቇળႎ๔ Anaerobe2008‫ ╙ޠ‬39 ࿁ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળ‫ޔ‬ጘ㒂‫ޔ‬2009.3.7.
2㧕 ↰ਛ㚅߅㉿㧦⻠Ṷ‫⩶⃿ࠨࡦ࡟ޟ‬ᗵᨴ∝ޯ∛ᘒߣ⸻ᢿ࡮ᴦ≮ߣ੍㒐ޯ‫ ╙ޠ‬116 ࿁ᗵᨴ㒐ᱛ⎇ⓥળ‫ޔ‬ฬฎደ‫ޔ‬2009.5.23
3㧕 ↰ਛ㚅߅㉿㧦ᢎ⢒⻠Ṷ‫㉄⎫ߣ࠻ࡅޟ‬ㆶర⚦⩶- Desulfovibrio ࠍਛᔃߦ - ‫ ╙ޠ‬12 ࿁ᣣᧄ⥃ᐥ⣺ౝᓸ↢‛ቇળ✚ળ‫ޔ‬ጘ㒂‫ޔ‬2009.9.54㧕 ᓟ⮮㓉ᰴ㧦ᢎ⢒⻠Ṷ‫ࡓ࡜ࠣޟ‬㓁ᕈህ᳇ᕈ⃿⩶ߩోࠥࡁࡓ⸃ᨆ‫ ╙ޠ‬39 ࿁ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળ‫ޔ‬ጘ㒂‫ޔ‬2009.3.7.
‫ޣ‬࿖ౝቇળᐳ㐳࡮มળ‫ޤ‬1) ᷰㆺ㇌෹㧦ࠪࡦࡐࠫ࠙ࡓ‫ ╙ޔ‬39 ࿁ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળ‫ޔ‬ጘ㒂‫ޔ‬2009.3.72) ᷰㆺ㇌෹㧦৻⥸Ṷ㗴‫ ╙ޔ‬12 ࿁ᣣᧄ⥃ᐥ⣺ౝᓸ↢‛ቇળ✚ળ‫ޔ‬ጘ㒂‫ޔ‬2009.9.5.
3) ᷰㆺ㇌෹㧦ᢎ⢒⻠Ṷ‫ ╙ޔ‬57 ࿁ᣣᧄൻቇ≮ᴺቇળ⷏ᣣᧄᡰㇱ✚ળ࡮╙ 52 ࿁ᣣᧄᗵᨴ∝ቇળਛᣣᧄ࿾ᣇળቇⴚ㓸ળ‫ޔ‬ฬฎደ‫ޔ‬2009.11.26-28.
4) ↰ਛ㚅߅㉿㧦৻⥸Ṷ㗴‫ ╙ޔ‬57 ࿁ᣣᧄൻቇ≮ᴺቇળ⷏ᣣᧄᡰㇱ✚ળ࡮╙ 52 ࿁ᣣᧄᗵᨴ∝ቇળਛᣣᧄ࿾ᣇળቇⴚ㓸ળ‫ޔ‬ฬฎደ‫ޔ‬2009.11.26-28.

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4㧚⎇ⓥ⾌₪ᓧ⁁ᴫ┹੎⊛⾗㊄⎇ⓥઍ⴫⠪㧦ᓟ⮮㓉ᰴ㧧ᐔᚑ 21 ᐕᐲᄢቇᵴᕈൻ⚻⾌㧔⎇ⓥ㧦⑼⎇ណᛯᡰេ㧕㧦Bacteroidesfragilis ߩᣂⷙࠗࡒࡍࡀࡓឃ಴ࡐࡦࡊߩหቯ㧧ᐔᚑ 21 ᐕᐲ㧧900 ජ౞ᅑቇነ㒝㊄ฃ౉

4ઙ

5㧚ቇળᵴേ
1㧕ቇળᓎຬᷰㆺ㇌෹㧦1) ᣣᧄᗵᨴ∝ቇળ⹏⼏ຬ࡮ਛᣣᧄ࿾ᣇળℂ੐㧔㨪ᐔᚑ 22 ᐕ 4 ᦬㧕2) ⥃ᐥᓸ↢‛ㄦㅦ⸻ᢿ⎇ⓥળᐙ੐㧔㨪⃻࿷㧕3) ᣣᧄൻቇ≮ᴺቇળ⹏⼏ຬ4) ᣣᧄ⥃ᐥ⣺ౝᓸ↢‛ቇળℂ੐㧔ᐔᚑ 20 ᐕ 9 ᦬㨪⃻࿷㧕5) ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ⹏⼏ຬ6) ᣣᧄ⥃ᐥᓸ↢‛ቇળ⹏⼏ຬ㧔㨪⃻࿷㧕7) ᣣᧄ⥃ᐥᓸ↢‛ቇળህ᳇ᕈ⩶ᬌᩏࡑ࠾ࡘࠕ࡞૞ᬺᆔຬળᆔຬ㧔ᐔᚑ 21 ᐕ 8 ᦬㨪⃻࿷㧕↰ਛ㚅߅㉿㧦1㧕ᣣᧄൻቇ≮ᴺቇળ⹏⼏ຬ
2㧕ᣣᧄ⥃ᐥᓸ↢‛ቇળ⹏⼏ຬ3㧕ᣣᧄ⚦⩶ቇળਛㇱᡰㇱ⹏⼏ຬ
4㧕ᣣᧄህ᳇ᕈ⩶ᗵᨴ∝⎇ⓥળㆇ༡ᆔຬ
5㧕ᣣᧄ⥃ᐥᓸ↢‛ቇળ ህ᳇ᕈ⩶ᬌᩏࡑ࠾ࡘࠕ࡞૞ᬺᆔຬળᆔຬ㧔ᐔᚑ 21 ᐕ 8 ᦬㨪⃻࿷㧕2㧕ቇળ㐿௅ᷰㆺ㇌෹㧦╙ 12 ࿁ᣣᧄ⥃ᐥ⣺ౝᓸ↢‛ቇળ✚ળቇⴚ㓸ળ‫ޔ‬ጘ㒂‫ޔ‬ᐔᚑ 21 ᐕ 9 ᦬ 5 ᣣ.
3㧕ቇⴚ㔀⹹ᷰㆺ㇌෹㧦⥃ᐥᓸ↢‛ㄦㅦ⸻ᢿ⎇ⓥળ⹹㧔JARMAM㧕
㧧✬㓸ᆔຬ㧔㨪⃻࿷㧕

6㧚␠ળᵴേ‫ޝ‬ህ᳇ᕈ⩶ᬌᩏ࠮ࡒ࠽࡯‫ޞ‬੹ᣣߩᄢቇකቇㇱߦ߅ߌࠆᗵᨴ∝ቇߩ⻠⟵߇ౝ⑼ቇߩ⻠⟵ో૕ߦභ߼ࠆഀวߪ‫ޔ‬ᭂ߼ߡዋߥ޿ߎߣ߇ࠊ߆ߞߡ޿ࠆ‫ޔߚ߹ޕ‬ᗵᨴ∝ቇߩਛߢ߽ህ᳇ᕈ⚦⩶ቇߦ㑐ߔࠆ⻠⟵ߩභ߼ࠆഀวߪߐࠄߦᭂ߼ߡዋߥߊ‫ߩߘޔ‬ᢎ⢒ߩ߶ߣࠎߤߪතᓟᢎ⢒ߦଐሽߒߥߌࠇ߫ߥࠄߥ޿⃻⁁ߢ޽ࠆ‫ޕ‬ᬌᩏᛛᏧߩᢎ⢒ߦ㑐ߒߡ߽ห᭽ߩߎߣ߇⸒߃ࠆ‫ޕ‬ህ᳇ᕈ⚦⩶ቇߣህ᳇ᕈ⩶ᗵᨴ∝ߩතᓟᢎ⢒ߦ߅ߌࠆᧄᣉ⸳ߩᓎഀߪ‫߇ࠊޔ‬࿖ߦ߅޿ߡᭂ߼ߡᄢ߈޿ߣ⠨߃ࠄࠇࠆ‫ޕ‬
ህ᳇ᕈ⩶ᗵᨴ∝ߪ‫ޔ‬ౝ⑼‫ޔ‬ᄖ⑼‫ޔ‬ᢛᒻᄖ⑼‫↥ޔ‬ᇚੱ⑼‫ޔ‬⡊㥦ຜ༄⑼‫ޔ‬ᱤ⑼ญ⣧ᄖ⑼ߥߤ᏷ᐢ޿
㗔ၞߢ⷗ࠄࠇ‫ޔ‬ህ᳇ᕈ⩶ߩ⥃ᐥᬌᩏߪᗵᨴ∝ߩ⸻ᢿ࡮ᴦ≮ߦ㊀ⷐߢ޽ࠆ‫ޔߪ࡯࠽ࡒ࠮ᧄޕ‬ህ᳇ᕈ⩶߅ࠃ߮ህ᳇ᕈ⩶ᗵᨴ∝ߦ⥝๧ߩ޽ࠆᣇ‫ᦨޔߦޘ‬ᣂߩᖱႎࠍ੤߃ߚో⥸⊛ߥ⍮⼂ߣᬌᩏߦ㑐ࠊࠆᛛⴚ㧔ᬌ૕ណข‫ޔ‬ಽ㔌‫ޔ‬ၭ㙃‫ޔ‬หቯ‫ޔ‬ㆮવሶᬌᩏߥߤ㧕ࠍ⠌ᓧߒߡ㗂ߊߎߣࠍ⋡⊛ߣߒߡታᣉߒ ̆3̆ߡ޿ࠆ‫ޕ‬
2009 ᐕ⻠⠌ౝኈ㧦ህ᳇ᕈ⩶ߩขᛒ߿⥃ᐥህ᳇ᕈ⩶ቇߦᔅⷐߥ⍮⼂ࠍቇ߱⻠⟵ߣ⥃ᐥ᧚ᢱ߆ࠄಽ㔌ߐࠇࠆਥⷐߥህ᳇ᕈ⩶ߩᒻᘒ࡮ᕈ⁁ⷰኤࠍਥ૕ߣߒߚታ⠌‫ޕ‬ታ⠌ߪ 2 ੱ 1 ⚵ߢታᣉߒ‫ޔ‬ታ⠌ࠍㅢߒߡህ᳇ᕈ⩶ߩಽ㔌࡮หቯ߹ߢࠍᛠី಴᧪ࠆࠃ߁ߦߥࠆߎߣࠍ⋡ᮡߣߒߚ‫ޕ‬ߎࠇ߹ߢߩ㐿௅࿁ᢙ㧦39 ࿁ ✚ෳടੱᢙ㧦⚂ 1,580 ฬ‫ޝ‬ህ᳇ᕈ⩶ߩ⩶ᩣ଻ሽ⁁ᴫߣ⩶ᩣߩಽਈ‫ޞ‬1㧕ህ᳇ᕈ⩶଻ሽ⩶ᩣߩ଻᦭⁁ᴫa) ህ᳇ᕈ⩶ෳ⠨⩶ᩣ⚂ 190 ᩣb) ฦ⒳ᗵᨴ∝‫∛ޔ‬ᘒ↱᧪ߩህ᳇ᕈ⩶⥃ᐥಽ㔌ᩣ
⚂ 6,600 ᩣᗵᨴ∝೎ౝ⸶㧦⢙㆏ᗵᨴ∝‫ޔ‬⣻⣧ౝᗵᨴ∝‫↥ޔ‬ᇚੱ⑼ᗵᨴ∝‫ޔ‬⡊㥦ຜ༄⑼ᗵᨴ∝‫ޔ‬ᢛᒻᄖ⑼ᗵᨴ∝‫ޔ‬ญ⣧ᄖ⑼㗔ၞᗵᨴ∝‫ޔ‬๭ๆེ⑼㗔ၞᗵᨴ∝ ↱᧪⩶ᩣ
 2㧕⩶ᩣߩಽਈ
ᣣᧄ⚦⩶ቇળᢎ⢒↪⩶ᩣߩಽਈ
⎇ⓥ↪⩶ᩣߩಽਈ㐿⊒⎇ⓥ↪⩶ᩣߩಽਈ

2 ⩶⒳ 2 ᩣ
39 ⩶⒳ 96 ᩣ2 ⩶⒳ 33 ᩣ7. ᡰេ࡮㒮ౝᗵᨴ⺞ᩏߦߣ߽ߥ߁ಽ㔌⩶ߩPFGE⸃ᨆ㧔ଐ㗬㧕㧦ቇౝ 2ઙ㧔15ᬌ૕㧕㧦ቇᄖ 1ઙ㧔11ᬌ૕㧕࡮㒮ౝᗵᨴ⺞ᩏߦߣ߽ߥ߁㥦⣧ᬌᩏ㧔ଐ㗬㧕㧦ቇౝ 1ઙ㧔300ᬌ૕㧕࡮⥃ᐥ᧚ᢱ߆ࠄಽ㔌ߐࠇߚህ᳇ᕈ⩶ߩᕈ⁁⹜㛎‫ޔ‬หቯ㧔ଐ㗬㧕㧦ቇౝ 2ઙ㧔2ᩣ㧕㧦ቇᄖ 13ઙ㧔23ᩣ㧕
࡮Ვ⩶᳓ߩ⚦⩶⧘⢩ߦኻߔࠆലᨐߩ⏕⹺㧔ଐ㗬㧕㧦ቇᄖ 1ઙ࡮วᚑ᦭ᯏൻว‛ߩ᛫⩶ജ᷹ቯ㧔ᣉ⸳೑↪߅ࠃ߮ᛛⴚᜰዉ㧕㧦ቇౝ 1ઙ
࡮C.difficileߩᲥ⚛↥↢ߦߟ޿ߡ㧔ᖱႎឭଏ㧕㧦ቇᄖ 2ઙ
࡮ህ᳇ᕈ⩶ߩหቯߦߟ޿ߡ㧔ᛛⴚ⋧⺣㧕㧦ቇౝ 2ઙ
࡮ህ᳇ᕈ⩶ߩಽ㔌࡮ၭ㙃ߦߟ޿ߡ㧔ᛛⴚ⋧⺣㧕㧦ቇᄖ 2ઙ࡮⥃ᐥ᧚ᢱ߆ࠄಽ㔌࡮หቯߐࠇߚህ᳇ᕈ⩶⒳ߦߟ޿ߡ㧔ᖱႎឭଏ㧕㧦ቇᄖ 2ઙ࡮⥃ᐥ᧚ᢱ߆ࠄಽ㔌ߐࠇߚህ᳇ᕈ⩶ߩ⥃ᐥ⊛ᗧ⟵‫ޔ‬᛫⩶⮎ᗵฃᕈߦߟ޿ߡ㧔ᖱႎឭଏ㧕㧦ቇౝ 3ઙ㧦ቇᄖ 3ઙ࡮ߘߩઁ㧔⋧⺣㧕㧦ቇᄖ 24ઙ

 

̆4̆

8. ᣉ⸳⸳஻ ጘ㒂ᄢቇ↢๮⑼ቇ✚ว⎇ⓥᡰេ࠮ࡦ࠲࡯ህ᳇ᕈ⩶⎇ⓥಽ㊁ߪ‫ޔ‬කቇㇱ᫟㧣㓏ߦ૏⟎ߔࠆ‫଻⛔♽ޕ‬ሽߩㇱደࠍ஻߃ߡ޿ࠆ‫ޕ‬ህ᳇ᕈࠣࡠ࡯ࡉࡏ࠶ࠢࠬ‫ޔ‬ህ᳇ᕈࡢ࡯ࠢࠬ࠹࡯࡚ࠪࡦ㧔ฦ 1 บ㧕ࠟࠬ⟎឵ⵝ⟎(1 บ)߰ࠄࠎེ‫ޔ‬὇㉄ࠟࠬࠗࡦࠠࡘࡌ࡯࠲࡯ࠢ࡝࡯ࡦࡌࡦ࠴቟ోࠠࡖࡆࡀ࠶࠻⥄േ⚦⩶หቯ‫ޔ‬ᗵฃᕈ᷹ቯࠪࠬ࠹ࡓ
DNA ࠪ࡯ࠢࠛࡦࠨ࡯ࠨ࡯ࡑ࡞ࠨࠗࠢ࡜࡯

9. ⥃ᐥህ᳇ᕈ⩶ቇߩዷᦸߦߟ޿ߡ ህ᳇ᕈ⩶ߩၭ㙃ᴺߩᡷ⦟ߦࠃࠅή⧘⢩ህ᳇ᕈ⩶ࠍ⎇ⓥߩኻ⽎ߣߔࠆ⎇ⓥ⠪ߪჇടߒߚ‫ޔ߫߃଀ޕ‬ᱤ๟∛∛ේ૕ߩ৻ߟߢ޽ࠆ Porphyromonas gingivalis ߩࠃ߁ߦ․ቯߩή⧘⢩ህ᳇ᕈ⩶ߩ⩶⒳ߦߟ޿ߡ‫ޔ‬∛ේ࿃ሶߩ⎇ⓥߥߤ߇‫ޔ‬ಽሶ↢‛ቇ⊛ߥ࡟ࡌ࡞ߢ߆ߥࠅᅏᷓߊⴕࠊࠇߡ޿ࠆ‫ⶄޔߒ߆ߒޕ‬ᢙ⩶ᗵᨴ∝ߢ޽ࠆή⧘⢩ህ᳇ᕈ⩶ߦࠃࠆᗵᨴ∝ߪ‫ޔ‬ᗵᨴᎽ߆ࠄߩή⧘⢩ህ᳇ᕈ⩶ߩ⩶⒳ࠍ୘‫⸃ߦޘ‬ᨆߔࠆߎߩࠃ
߁ߥಽሶ↢‛ቇ⊛ࠕࡊࡠ࡯࠴ߩઁߦ‫ޔ‬ᗵᨴᎽߩή⧘⢩ህ᳇ᕈ⩶ࠍᅢ᳇ᕈ⩶ߣߩ㑐ࠊࠅߩਛߢ✚ว⊛ߦ⸃ᨆߔࠆᔅⷐ߇޽ࠆ‫ߩࡎ࠶ࠦޕ‬ේೣߦว⥌ߒߥ޿ህ᳇ᕈ⩶ᗵᨴ∝ߩ⊒↢ᯏ᭴ߩ⸃᣿ߦߪ‫⥃ޔ‬ᐥߣㅪ៤ߒߚ⹦⚦ߥࠕࡊࡠ࡯࠴߇ᔅⷐߢ޽ࠆ‫ޕ‬ ߹ߚ‫ޔ‬㜞㦂ൻ␠ળߩ೔᧪ߦࠃࠆක≮ࠦࠬ࠻ߩ਄᣹ߦኻߔࠆ޿ࠈ޿ࠈߥኻ╷߇⻠ߓࠄࠇࠆࠃ߁ߣߒߡ
޿ࠆ‫ޔߦ․ޕ‬ᣂߒߊណ↪ߐࠇࠆᣇะߦ޽ࠆක≮೙ᐲߩ዁᧪ߩᄌ㕟ߩᣇะᕈߦࠃߞߡߪ‫⑼ޔ‬ቇ⊛ߥᕁ⠨ߣࠕࡊࡠ࡯࠴߇ᔅⷐߢ‫ޔ‬කቇ⊛ߦㆡᱜߥᬌᩏ⸘↹߇ᔅⷐߣߥࠆ‫ޕ‬ᗵᨴ∝ߩ⸻ᢿᴦ≮ߦ㊀ⷐߥၭ㙃߿หቯ߇ᾘ㔀ߥህ᳇ᕈ⩶ߦ㑐ߔࠆᬌᩏࠍߤߩࠃ߁ߦⴕߞߡ޿ߊ߆ߪᄢ߈ߥ㑐ᔃ੐ߢ޽ࠆ‫ޕ‬ಽሶ↢‛ቇ⊛ᚻ
ᴺߦࠃࠆㄦㅦൻߪ‫ޔ‬ಽ㔌ߒߚ⩶ߩหቯᴺߣߒߡߪᄢ޿ߦᦼᓙߐࠇࠆ߇‫ޔ‬ᣥ᧪߆ࠄߩ↢‛ቇ⊛ᚻᴺ߽シⷞߔࠆߎߣߪߢ߈ߥ޿‫ߩࠄࠇߎޕ‬ᣇᴺ⺰ࠍⲢวߐߖߚᗵᨴ∝ߦኻߔࠆᬌᩏᴺߩࠟࠗ࠼࡜ࠗࡦࠍᢛ஻ߒ
ߡ޿ߊߎߣߪ⾰ߩ㜞޿ක≮ࠍⴕ߁਄ߢᭂ߼ߡ㊀ⷐߢ޽ࠆ‫ޔߦ․ޕ‬ህ᳇ᕈ⩶ᗵᨴ∝ߩਛߢ߽૕ౝᷓㇱߦ⊒↢ߔࠆ∛ᄌߢ‫ޔ‬ᬌ૕ណข߇࿎㔍ߥᗵᨴ∝ߦ߅ߌࠆህ᳇ᕈ⩶ߩ㑐ਈࠍᣧᦼߦᱜ⏕ߦ⍮ࠆߦߪ‫ޔ‬ಽሶ↢‛ቇ⊛ᚻᴺએᄖߩᣂߒ޿ᚻᴺߩ㐿⊒߇ᔅⷐߢ޽ࠆ‫ޕ‬ ᖡᕈ⣲≌߿♧ዩ∛‫ߪߦࠄߐޔ‬⒖ᬀ߿ᓟᄤᕈ఺∉ਇో∝୥⟲ߥߤ఺∉ਇోኋਥ߇῜⊒⊛ߦჇടߒߟߟ޽ࠆ੹‫ߦ⤑☼ߩੱޔ‬ఝ൓ߦሽ࿷ߔࠆẜ࿷⊛∛ේᕈࠍ᦭ߔࠆᣣ๺⷗∛ේ૕ߢ޽ࠆή⧘⢩ህ᳇ᕈ⩶ߩ㊀ⷐᕈߪ߹ߔ߹ߔ㜞ߊߥࠆߢ޽ࠈ߁‫੹ޕ‬ᓟ‫⥃ޔ‬ᐥߣߩኒធߥ౒ห⎇ⓥ߇ߢ߈ࠆࠃ߁ߥᣂߒ޿⚵❱ߠߊࠅࠍᮨ⚝ߒߡⴕߊ੍ቯߢ޽ࠆ‫ޕ‬

ઃ⴫. ⥃ᐥ᧚ᢱ࡮ᱜᏱ⚦⩶ฌߦߺࠄࠇࠆਥߥህ᳇ᕈ⩶Phylum BXIII Firmicutes
Class㧔✁㧕 I
Clostridia
Order (⋡) I Clostridiales
Family(⑼) I. Clostridiaceae
Genus Clostridium
C. perfringens
C. bifermentans
C. novyi ̆5̆C. sordellii
C. butyricum
C. coccoides
C. sphenoidesC. oroticum
C. innocuum
C. ramosumC. scindens
C. hylemonae
C. hiranonis
C. sporogenes
C. clostridiiforme
C. paraputrificum
C. putrificum
C. septicum
C. difficile
Family III. Peptostreptococaceae
Genus Peptostreptococcus
P. anaerobius
P. stomatis
Genus Finegoldia
F. magna
Genus Parvimonas
P. micra
Genus Peptoniphilus
P. asaccharolyticus
P. hareiP. lacrimalis
P. ivorii
P. indolicus
Genus Anaercoccus
A. prevotii
A. hydrogenalis
A. tetradius
A. vaginalis
A. lactolyticus
Genus Filifactor
F. alocis (φFusobacterium alocis )Family IV. Eubacteriaceae
Genus Eubacterium
E. saphenum
E. nodatum
E. saburreum
E. sulci (φFusobacterium sulci )E. brachy
Genus Mogibacterium
M. timidum
Genus Pseudoramibacter ̆6̆

P. alactolyticus
Family V. Peptococcaceae
Genus Peptococcus
P. niger
FamilyVII. Acidaminococcaceae
Genus Dialister
D. pneumosintes
D. invisus
D. microaerophilus
D. propionifaciens
Genus Selenomonas
S. sputigena
S. fluggei
S. infelix
S. noxia
S. dianae
S. artemidis
Genus Veillonella
V. parvula
V. atypica
Class II MollicutesOrder V.
Incerta sedis
Family Erysiperotrichaceae
Genus Bulleidia
B. extructa
Genus Solobacterium
S. moorei
Class III “Bacilli”
Order I. Bacillales
Family VII. Staphylococcaceae
Genus Staphylococcus
S. saccharolyticus
Genus Gemella
G. haemolysans
G. morbillorum
Order II. Lactobacillales
Family I.
Lactobacillaceae
Genus Lactobacillus
L. salivarius
L. acidophilus
L. brevis
L. caseiL. fermentum
L. plantarum
L. reuteri

Phylum BXII Proteobacteria
ClassII. Betaproteobacteria ̆7̆Order I. Burkholderiales
Family III. Alcaligenaceae
Genus SutterellaS. wadsworthensis
Order IV. Neisseriales
Family I. Neisseriaceae
Genus Eikenella
E. corrodens
Class IV. Deltaproteobacteria
Order II. Desulfovibrionales
Family I. Desulfovibrionaceae
Genus Desulfovibrio
D. pigerD. desulfuricans
Genus Bilophila
B. wadsworthia

ClassV. Epsilonproteobacteria
Order I. Campylobacterales
Family I. Campylobacteriaceae
Genus Campylobacter
C. gracilis
C. concisus
C. rectus
C. showae
Phylum BXX. Bacteroidetes
Class I. Bacteroidetes
Order I. Bacteroidales
Family I. Bacteroidaceae
Genus Bacteroides
B. fragilis
B. thetaiotaomicronB. vulgatus
B. uniformis
B. ovatus
B. caccae
B. stercoris
B. nordii
B. salyersiae
B. finegoldii
B. nordii
B. eggerthii“B. ureolyticus”
Genus Parabacteroides
P. distasonis
P. goldsteinii
P. johnsonii ̆8̆P. merdae
Genus Megamonas
M. hypermegas
Family III. Porphyromonadaceae
Genus Porphyromonas
P. gingivalis
P. endodontalis
P. bennonis
P. cangingivalis
P. salivosa
P. gulaeP. gingivicanis
Family IV. Prevotella
Genus Prevotella
P. intermedia
P. nigrescens
P. denticola
P. loescheii
P. melannogenica
P. pallens
P. corporis
P. tannerae
P. buccae
P. orisP. oralis
P. veroralis
P. heparinolytica
Class III. Flavobacteria
Family I. Flavobacteriaceae
Genus Capnocytophaga
C. ochracea
Phylum BXXI. Fusobacteria
Class I. Fusobacteria
Order I. Fusobacteriales
Family Fusobacteriaceae
Genus Fusobacterium
F. nucleatum
F. necrophorum
F. varium
F. mortiferum
Genus Leptotrichia
L. buccalis
Class I. Actinobacteria
Subclass III. Coriobacteridae
Order I. Coriobacteriales ̆9̆Suborder I. Coriobacterinae
Family I. CoriobacteriaceaeGenus Atopobium
A. parvulum(φStreptococcus)
A. minutum(φLactobacillus)
A. vaginae
Genus Collinsella
C. aerofaciens
C. stercoris
C. intestinalis
Genus Cryptobacterium
C. curtum
Genus Eggerthella
E. lenta(φEubacterium)
Genus Slackia
S. exigua(φEubacterium )Subclass V. Actinobacteridae
Order I. Actinomycetales
Suborder I. Actinomycineae
Family I. Actinomycetaceae
Genus Actinomyces
A. naeslundii
A. turicensis
A. israelii
A. odontolyticus
A. radingae
Genus Mobiluncus
M. mullieris
M. curtis
Suborder IV. Propionibacterianeae
Family I. Propionibacteriaceae
Genus Propionibacterium
P. acnes
P. avidum
P. granulosum
Order II. Bifidobacteriales
Family I. Bifidobacteriaceae
Genus Bifidobacterium
B. breve
B. longum
B. adolescentis
B. bifidum
B. pseudolongum
Genus Falcivibrio
Genus Gardnerella
G. vaginalis
Genus Parascardovia (φBifidobacterium) ̆10̆

P. denticolens
Genus Scardovia (φBifidobacterium)
S. inopinata ̆11̆