Process Chemistry

End old routines
Walk up, set up your run and walk away. Freeslate jr. turns reaction screening andprocess optimization into totally routine activities. Build a system for reaction screening
and plow through hundreds of modifications per week. Deck one out with real-timesampling to fine tune your chemistry pathways. Freeslate jr. lets you dive deep so you
know exactly what tweaks to make next.

• Process optimization• Screen continuous variables• Screen discrete variables• Optimize and screen new synthetic routes• Improve yields and impurity profiles• Optimize catalyst loading• Map process robustness

Dial in your process
Freeslate jr. lets you check out a ton of reaction screening variables like solvents,ligands, catalysts and reagents all at once. It’ll plow through hundreds of modifications
per week. Outfit one with an Optimization Sampling Reactor (OSR) to grab samples
from your reactions as they’re happening and know even more right now.

12

3

1 Solvent tray
2 Optimization Sampling Reactor
3 3-Position vortexing station

4564 Wash station
5 Heating/cooling/stirring bay
6 3-Position plate rackFind the sweet spot
Going the one variable at a time route doesn’t cut it when you need to know how all
your different reaction variables play together. Add an Optimization Sampling Reactor(OSR) to freeslate jr. and get real-time kinetics on all your reactions. OSR grabs timepoint samples from up to 8 pressure and temp-controlled vessels at a time without
interrupting a single reaction. Each vessel makes sure the heating, cooling and stirring
for each of your reactions is just right.

Optimization Sampling Reactor

Cover all the bases
Freeslate jr. screens all your substrates, catalysts, reactants, solvents and reaction
conditions so you can tackle a huge range of organic transformations. Dead-on dosingof small amounts of solids, liquids, slurries and viscous reagents keeps use of preciousand expensive materials at an all-time low when prepping your reaction solutions. Tight
reaction control, stir plate temps, filtration and dilution means your samples are readyfor structural analysis whenever you are.

Solid dispensing tools

Heated 4-tip
liquid dispenser

Heating/cooling/stirring
stationTake reactions higher
Ultra-high temp and pressure reactions are no problem with the Screening Pressure
Reactor (SPR). Run up to 96 experiments in parallel automatically and kick things up to400 °C and 200 bar (3000 psig). Tie an SPR in with freeslate jr. for reaction screening
and see if maxing temps and pressures gets your chemistry where you want it to go.

Screening Pressure Reactor

Break through bottlenecks
LEA doesn’t move the bottleneck, it totally unclogs it. You get intuitive experimental designthat makes sense on the front end and full integration with analytical tools on the backend. LEA also links your conditions, steps and analytical data together, so your final reportdoesn’t just have numbers, it’s got all the information you need to make real decisions.

Library Studio
Design complex, high-throughput
experiments in an array-basedformatPolyView
Review and report all info
from experimental design,
execution and analytics

Automation Studio
Execution of designed
experiments and integrated
analytics

Unchained Labs
6940 Koll Center Pkwy, Suite 200
Pleasanton, CA 94566
Phone: 1.925.587.9800
Toll-free: 1.800.815.6384
Email: info@unchainedlabs.com© 2016 Unchained Labs. All rights reserved. The Unchained Labs logo and freeslate jr. are trademarks
and/or registered trademarks of Unchained Labs.