ProductsSolutions

Services

Heartbeat Technology inthe life sciences industry
Promass 100/300/500
Verification
Heartbeat Technology
The pulse of your measurement
Do you want to increase yourplant’s availability and decrease
costs? With Heartbeat Technology,
Endress+Hauser offers the widest
choice of measuring devices
incorporating a groundbreaking
diagnostics and verification
concept designed with this purposein mind.
Through a clever combinationof diagnostics, verification andmonitoring, Heartbeat Technology
enables safe and cost-efficientplant operation throughout theentire life cycle.

Proline Promass P 100 Coriolis flowmeter

The challenge of the „biotech
revolution“ Manufacturers are
increasingly finding themselvesconfronted with what is known as
the „biotech revolution“, with thefocus of their work shifting awayfrom chemical process technology
and towards biological process
technology. In terms of their Good
Manufacturing Practices (GMP),
this entails new regulatory
requirements for manufacturers.
However, these can simultaneously
bring about worthwhile simplifications.
Historically, pharmaceuticalmanufacturers have used theirmeasuring instruments solely forthe primary measured variables they
provide. Device maintenance is still
performed on a preventive basis.
Measuring devices are calibrated atregular intervals based on how criticalthey are to product quality, a task
associated with considerable
maintenance costs. In aseptic
processes, measures must be taken
to counteract the hygiene risks posed

when sterile pipes have to be opened
up in order to perform a calibration.
In most cases, it emerges that themajority of measuring instruments
are functioning faultlessly and that
longer periods of system downtime
could be avoided.
Requirements for an optimized
solution What is needed is a GMPcompliant solution that improves
plant availability and that verifies
the reliability of measured values atlittle cost. Should calibrations still berequired, the cycles involved should
be extended significantly.

Our solution With Heartbeat Technology, the manufacturer
verifies the measuring point while it is installed.
Meanwhile, the process and measurements continue to
run without any restrictions. Verification takes placeeither on site or from the comfort and safety of the control
room. A PDF document, which is generated and maintainedusing asset management software (DTM), provides
verification of the measuring device’s status.
Benefits Heartbeat Technology is capable of verifying
measuring point functionality in minimum time to a levelsuitable for audit purposes. Plant availability is not restricted.
The operator therefore has complete flexibility whenscheduling a measuring point inspection for compliancewith standards. In comparison with verifications performed
using external test equipment, the verification function
integrated in the measuring device leads to a time saving ofat least 80%. Calibration cycles are extended from one year
to two to three years. This results in a considerable reduction
in maintenance costs and increased plant availability.
Sterile pipes are opened up less often, resulting in increased
product safety.
Documentation becomes child’s play, as commonly available
asset management tools are used to generate and maintainthe verification report. Individual tests are performed freeof charge using Heartbeat Technology and can therefore be
performed anytime prior to the commencement of a new
production batch, for example in the case of reassembly or“good-to-go” checks.

Savings• Time saving of 1.5 hours per verification = €150
per verification. The additional cost of theHeartbeat option is recouped after just the thirdverification.
• Calibration is required only every 2-3 years insteadof annually. The savings per device range from€500 – €1,000 per verification. The cost isrecouped once the first calibration is dispensed with.
• Guarantee of significantly higher returns due toplant availability.

Avoid unnecessary maintenance work and increase
product safety as well as plant availability using
Heartbeat Technology!

PU01203D/00/EN/01.17

www.addresses.endress.com