Into the

futurewith
YUKI

Head Office10-4, Nihonbashi-Ningyocho 3-chome, Chuo-ku, Tokyo 103-0013
TEL +81-3-3664-3980 FAX +81-3-3664-3998
www.yuki-gosei.co.jp/en/
June 2024

CORPORATEPROFILEInto thefuturewith
YUKI

We have been engaged in research and development in the field of organic chemistry since ourCreating products that are apleasure to use

INDEX

founding in 1947. We have dedicated ourselves to manufacturing high-quality products in the food,Into the future with YUKI ・・・・・・・・・・・・・2

pharmaceutical and industrial products fields, with the sole purpose of fulfilling our mission to create

The Core Fields at YUKI ・・・・・・・・・・・・・・・4

products that are a pleasure to use.
We don’t merely develop our own products, but also emphasize custom production and custom
manufacturing to ensure customers a reliable supply of products that meet their needs.
YUKI is the link to your bold future with our lineup ranging from unique high value-added products tohighly-versatile products such as glycine, which was originally developed by us.

		Enriching Lives(Foods)
		Protecting Health(Pharmaceuticals)
		 Creating the Future(Industrial Products)

The Craft of Manufacturing at YUKI・・8
		 Sales Activities/Basic Technology Research
		 Mass Production Technology Research/				Manufacturing Sites
		Quality Assurance and Control
		Custom Manufacturing		(Chemical and pharmaceutical products) ・・・・・・14

Global Expansion at YUKI ・・・・・・・・・・・16
About YUKI ・・・・・・・・・・・・・・・・・・・・・・・・・・・・18

2

3

Enriching people’s lives throughproducts using chemical
technology

Enriching
Lives

YUKI manufactures and continuously supplies products in thefood, pharmaceutical and industrial products fields.

Creating
theFutureWe support you and your future through common daily foods inmany situation in everyday life.

Protecting
HealthFoods

The first to commercialize
glycine in Japan

EnrichingLives

Growing and developingin tandem with the foodindustry
We commenced manufacturing andmarketing glycine as a taste component
for synthetic sake in 1952 for the first timein Japan. Since then, glycine has beenused over many years as a preservative to
make food last longer and delay spoiling,
as well as a flavor enhancer for a wide
variety of foods.

One of the largest glycine
facilities in the world

Expansion into new markets

We focus on improving
quality and ensuring safety

Responding to changes inpeople’s lifestyles

Our glycine manufacturing facility is oneof the largest in the world. Our efforts arefocused not only on improving quality
and assuring safety but also ensuringthat the standards for quality control
are as high as for pharmaceuticals. We
are an established supplier of glycine
manufactured under our strictly
controlled manufacturing system both todomestic and overseas markets.

The development of supplements andfunctional foods in response to increased
health awareness has been remarkable,with their number and variety increasing
significantly. We are developing productsthat reflect changing lifestyles.

Enriching lives through taste and nutrition

Glycine is known as a safe preservative which is used to make food last longer and delay spoiling, as well as a flavor enhancer.
We were the first company in Japan to start manufacturing and marketing glycine in 1952. The technology for producing
glycine and other amino acids is one of our key technologies. We are an established supplier of glycine to markets both inJapan and abroad.

4

Main products :glycine, glycine formulations, nicotinamide

Major applications : shelf life extension of foods (e.g. rice balls, prepared foods, pastries), flavor enhancement(e.g. pickles, instant noodles)

5

Pharmaceuticals

Protecting
Health

Products that meet international
quality standards

Custom manufacturing ofpharmaceuticals

Manufacturing products thatare safe and comply withnational standards

Using high technology tomeet customer needs

Our products are manufactured
in compliance with GMP and thelatest regulations. The quality of our
products complies with the JapanesePharmaceutical legislation and has beensuccessfully audited by the US FDA andthe UK MHRA. We guarantee the highest
quality and safety standards.

In custom manufacturing of APIs andintermediates for new pharmaceuticals
and generics, we meet diverse customer
needs by establishing the manufacturing
process in our research department,
manuf ac turing using cut ting-edge
facilities, and applying a quality assurance
system that meets international
standards.

Global expansion of our
proprietary products

Contributing to people’s
health through products
developed by our company
APIs that we have developed include
protamine sulfate, an anti-heparin agent;isoniazid, an anti-tuberculosis agent; andtrifluorothymidine, an antiviral ophthalmic
solution. We contribute to improving
people’s health through manufacturingand marketing these ingredients.

Protecting health with products that meet strict international quality standards

Our products meet the requirements of Japanese pharmaceutical legislation and have passed audits by the US FDA and UK
MHRA, ensuring world-class quality.

Major products :We are engaged in custom manufacturing of APIs and pharmaceutical intermediates for new pharmaceuticals and generics.

Major applications : infusion preparations, antiviral ophthalmic solutions, anti-heparin agents, anti-tuberculosis agents,
expectorant agents

We also market our own APIs and are ready to meet customer needs flexibly.

APIs (glycine, isoniazid, protamine sulfate, etc.), pharmaceutical intermediates, cosmetic ingredientsIndustrial Products

Creating
theFutureDevelopment and manufacturing ofproducts with unique characteristics

Contributing to the developmentof an information society

Protecting the ecosystem andthe environment

Our products support
people’s lives in various areas

Applying our technology toelectronic materials

The organosilicon compounds that
our company manufactures are usedin manufacturing semiconductors andas starting materials for underwaterhull paints. Our pyridine derivatives areused as the main ingredient in tire cordadhesives, and amino acid derivatives aschelating agents for industrial use.

The manufacturing of semiconductors
and electronic devices requires strict
control. Based on our experience indeveloping and manufacturing foods andpharmaceuticals, we have harmonizedproduct development and manufacturingt o m e e t th e r igo r o u s s t an d ar d s o f
semiconductor and other manufacturers.

Continuing to protect people’s
health, the ecosystem andnatural beauty for the future
We manufacture starting materials andintermediates for agricultural chemicals
produced with concern for human health andthe environment. We have raised our efforts toconserve the environment in all manufacturing
processes and support our customers’ CSR
activities by supplying environmentally friendly
chemical products.

Creating the future with products that enable cutting-edge technology

In the rapidly advancing field of industrial products we support various industries, by manufacturing raw materials forindustrial functional materials such as semiconductors and silicon wafers.
We also supply high-quality raw materials for manufacturing agricultural chemicals produced with concern for humanhealth and the environment.

6

Main products :organosilicon compounds, pyridine derivatives, amino acid derivatives

Major applications : electronic materials; raw materials for paints, synthetic resins, and tires; industrial chelating agents; raw materials
for agricultural chemicals

7

The Craft of Manufacturing at YUKI

Sales
Contributing to the Future in Three Areas

The Craft of Manufacturing at YUKI
Our company started with researchers synthesizing tobacco flavors in a university
laboratory. The founders’ hope of making chemical technology useful for everyone has
been passed on to all YUKI employees. In the spirit of this hope, staff members in Sales,
Basic Technology Research, Mass Production Technology Research, Manufacturing, andQuality Assurance and Control cooperate with each other based on their experience

Linking customers and manufacturing to shape the future
Professionals from three product categories who are familiar with productdevelopment and the production system are ready to respond to customers’ needs.
We offer support to customers in many markets around the world.

and expertise in order to contribute to the future in YUKI’s food, pharmaceutical andindustrial products fields.
Mobile staff structure helps identify customer
needs quickly and accurately

Mass Production
Technology Research

Professionals from the Food product category, Industrial Chemicals
product category, and Pharmaceuticals product category are
responsible for different regions. We are ready to respond dynamicallyand effectively to increasingly diverse demands.

Ensuring successful scale-up
to mass production

Basic Technology
Research

Quality Assurance andControl

Manufacturing
Sites

Proposing optimal
manufacturing processes
and products

Supporting the manufactureof world-class quality
products

Never missing the slightestchange in order to assure
stable production

Sales
Forming the future bylinking customers andmanufacturing

Specialists that understand product development
Many of our sales staff have experience in research and development.
Staff with product expertise listen closely to customers and consult
them to meet their needs. Through close cooperation with staff incharge of research and manufacturing, sales staff can respond flexibly tocustom manufacturing requests.

Information support on pharmaceutical and otherissues in different countries
Our sales staff are specialists that help meet strict standards and testing
requirements, especially for food and pharmaceuticals, as well as helping
to supply products around the world. We have a support system in placeproviding information and compliance support services for various
national regulations as part of a wide palette of support services.

Food

Industrial Chemicals

Pharmaceuticals

This category is concerned with amino acids,
especially glycine and β-alanine. Glycine, which has
become synonymous with our company, is a productwhich is sold extensively, mainly for use in the foodindustry.

This category mainly deals with pyridine derivatives(used in tires, agricultural chemicals, pharmaceuticals,etc.) and organosilicon compounds (used in synthetic
resins, semiconductors, etc.), and offers custom
manufacturing services.

This category deals with API's and pharmaceuticalintermediates and the development of new productswith a focus on the healthcare field. The division
helps meet the strict standards of different countries
around the world in custom manufacturing.
Emphasis is also placed on generic APIs.

From the Factory Floor

Sales staff thoroughly familiar with the manufacturing
facilities provide full support for custom manufacturing

Customer
Proprietary
Products

8

CustomManufacturing

Many members of the sales staff have experience as researchers. I worked in the
Research Laboratory before being assigned to sales. Our hands-on experienceand knowledge regarding research and manufacturing allow us to offer support
in close cooperation with various departments to ensure a smooth transition frommanufacturing to delivery of products that meet customers’ needs. Particularly withregard to custom manufacturing, a researcher's perspective enables us to propose
the most suitable manufacturing processes that meet legal regulations. You canrely on our staff, who have decades of experience in providing numerous products
throughout the world.

9

The Craft of Manufacturing at YUKI

The Craft of Manufacturing at YUKI

Basic Technology Research

Mass Production Technology Research(Tokyo Research Laboratory)(Joban Factory)

Proposing optimal manufacturing processes and products

Ensuring successful scale-up to mass production

The Research Laboratory is mainly engaged in the development of technologies unique to our company andpreparing the basic design for custom manufacturing.
In custom manufacturing, our system allows us to respond to customer requests precisely and in a timely manner.

To achieve mass production, we identify the best manufacturing method with respect to the productcharacteristics and conduct research and development that leads to tangible results.
In the pharmaceutical field, we also provide services that meet customer needs, such as compliance with GMP.

Taking advantage of technology development
capabilities unique to our company to develop andoffer new products

Trial manufacturing on the actual manufacturing
equipment to support production
The Manufacturing Technology Department located within the
Joban Factory develops, in cooperation with manufacturing staff,
manufacturing methods that ensure quality improvement andproduction stability in the run up to mass production. We use the actual
manufacturing equipment from the trial manufacturing stage to verify
scale-up procedures and after establishing a mass production system,
we continue our improvement efforts in pursuit of a more efficient andstable production system.

We use our own technologies effectively to develop new products withunique characteristics, such as pyridine and piperidine compounds,
organosilicon compounds, amino acid derivatives, and nucleic-acid
derivatives. We supply chemical compounds such as pharmaceuticals,
pharmaceutical intermediates, paints and polymeric materials that havebeen developed by our company for a wide variety of fields, ranging
from the pharmaceutical industry to the electronics industry.

Designing manufacturing processes that meetlegal requirements

Achieving high quality through meticulous
analysis

Our dedicated staff gather and analyze information on products desiredby each customer, as well as information on what legal requirements
need to be met. Tokyo Research Laboratory swiftly performs scale-up
from small laboratory trials to pilot manufacturing. We make the mostsuitable proposals for fulfilling customer needs, based on technologies
accumulated over the years.

We analyze the structures of trace impurities and crystal polymorphs
using a variety of high-performance analytical equipment such as NMR,
GC/MS, LC/MS, powder X-ray diffractometer and SEM. Based on theanalysis results, manufacturing processes that ensure high quality aredeveloped.

Meeting modern needs with rapid development

Our company has accumulated industrial technology and know-how,including hydrogenation reactions using organometallic reagents
such as Grignard reagents and transition metal catalysts. We use suchtechnologies to commercialize not only pharmaceuticals but also
rapidly changing electronics-related materials, functional materials, andpolymer-related materials.

Product life cycles in the market are getting shorter. It is therefore
essential to deliver better products to customers quickly. At the factory,
we cooperate with the basic technology research department and the
manufacturing department to achieve a smooth transition to mass
production, while prioritizing rapid research and development.

<Principal Analytical Equipment><Principal Analytical Equipment>

NMR, IR, GC, GC/MS, HPLC, UPLC, LC/MS,
atomic absorption spectrometer, thermal
analyzer, refractometer, UV-VIS, polarimeter,colorimeter, ion chromatograph, amino acidanalyzer.

SEM, ICP, powder X-ray diffractometer,
GC, GC/MS, HPLC, atomic absorption
spectrometer, ion chromatograph, particle
size analyzer, specific surface area meter,
thermal analyzer.

From the Factory Floor

Preparing products that are safe and reliable efficiently
according to a plan that is tailored to your company needs
In response to customer needs, Tokyo Research Laboratory's activities include
carrying out scientific surveys, and range from laboratory trials of several grams up
to manufacturing with experimental facilities on the scale of dozens of kilograms.
The manufacturing process is always designed in close cooperation with Quality
Assurance and Quality Control, which are responsible for issues related topatents and applications. To achieve commercialization that meets international
standards, we present an efficient plan that has been optimized for the customer.

10

Accumulating and applying industrial technology

From the Factory Floor

Applying advanced technology for transition to mass
production to enable large scale production even whenscale-up of the manufacturing process is difficult
After assessing scale-up to mass production of a new product developed at the Tokyo
Research Laboratory, the product is manufactured at the Joban Factory. To prevent
possible problems, especially when starting mass production of a newly launched
product or a product that is handled for the first time, thorough, repeated assessments
are made before scaling up and strict risk management is implemented. In addition toopinion sharing and collaboration within the Joban Factory, we cooperate closely with
the Tokyo Research Laboratory to facilitate efficient transition to large-scale production.
As a staff member responsible for scaling up, I also monitor production at the factory.

11

The Craft of Manufacturing at YUKI

The Craft of Manufacturing at YUKI

Manufacturing Site

Quality Assurance and Control(Joban Factory)(Joban Factory, Head Office)

Never missing the slightest change in order to assure stable production

Supporting the manufacture of world-class quality products

The Joban Factory is our company’s primary manufacturing site for amino acids, APIs, industrial chemicals and other products.
A variety of products, ranging from general-purpose products to high value-added products, are manufactured with highperformance manufacturing facilities under an efficient production system.

One of the most important responsibilities for manufacturers is product quality assurance and quality control.
Our Quality Assurance Division is independent of manufacturing in order to maintain a quality management
system that meets international requirements.

Manufacturing facilities for pharmaceutical and chemical products

Manufacturing facilities for amino acids (glycine and β-alanine)

API manufacturing in compliance with strict
international quality standards

Amino acid manufacturing trusted by customers inJapan and abroad

APIs such as isoniazid, protamine sulfate and trifluorothymidine, areproduced using GMP-compliant cutting-edge facilities, under a processcontrol system that complies with the standards of Japan, the UnitedStates and Europe.

Our company’s glycine manufacturing started with organic synthesis
research at the University of Tokyo in 1951. We have been supplying
high-quality glycine for many years, not only in Japan but also
around the world. This manufacturing process is also applied to the
manufacture of β-alanine, which is used as an ingredient in vitamins.

Custom manufacturing that meets diverse needs

Manufacturing system that ensures a stable supply

Our manufacturing facilities can handle many kinds of reactions, whichallow us to offer custom manufacturing services that meet a variety ofcustomer needs.

Various manufacturing facilities, including one of the largest facilities
for glycine manufacturing in the world are operated effectively undercentral control, with the highest priority placed on safety.

Pursuing high quality and guaranteeing safety
The quality of our pharmaceuticals meets Japanese requirements as wellas the US FDA’s and the EU’s requirements. We have adopted the ISO
9001 Quality Management System since 1998, and in 2021, we acquired
FSSC 22000 certification, an international scheme for Food Safety
Management Systems, to improve and enhance the quality assurance
and control system.

私 たFrom
ち が the
選 ばFactory
れ 続 けFloor
る理由

Assuring product quality as a professional
analytical chemist

The Quality Assurance Division helps to ensurethat products meet international standards

I inspect products before shipment. Our company offers many
types of products, and therefore, abundant data on them thathas been obtained from tests and examinations is available. We
perform a thorough final inspection to ensure the quality of eachproduct. In order to verify and ensure product quality, we conductvarious kinds of tests and examinations.

We are responsible for all internal activities involving product quality(GMP and ISO). Our company supplies products that are safe andmeet the strict standards of different countries, by incorporating
the latest information and at the same time taking advantage of ourabundant experience in custom manufacturing over many years.

From the Factory Floor

Ensuring stable product supply as well as pursuing highquality and low cost
It is essential for the factory to ensure a steady supply of products to the market.
In addition to operation of the factory to manufacture products, it is also our task
to pursue high product quality and low costs. I cooperate with other members at
the worksite to operate large-scale facilities in order to mass produce products.
We are required to carry out assigned work safely and accurately according topredetermined procedures. Furthermore, individual members are active in taking
measures to make manufacturing more efficient by, for example, identifying
methods that are more efficient in our daily activities in manufacturing processes
and making proposals for improvement if necessary.

12

Environmental efforts
To be “a company that coexists with nature inharmony and that is environmentally friendly,”
we are active in environmental conservation.
We have adopted the ISO 14001 Environmental
Management System since July 1997.

Water pollution
prevention

Air pollution
prevention

Waste reduction andrecycling

Industrial wastewater from the factory
is discharged into public waters only
after being purified with equipment
for activated sludge treatment.

We have adopted a small-sized
once-through boiler to achieveenergy saving and prevent air
pollution.

We use our own liquid waste
incineration facilities as well as
external waste treatment services
to treat and recycle waste.

13

Meeting customer needs
with our expertise andspecialized facilities
CustomManufacturing ofPharmaceuticals

CustomManufacturing

There are various regulations on pharmaceutical development and manufacturing both in Japanand elsewhere. Based on our experience, we provide our customers with extensive support,
supplying them with highly reliable products under our GMP-compliant quality assurance system.

Our Strengths
We offer custom manufacturing services fora variety of products, from general-purpose
products to high value-added products. With
regard to pharmaceuticals, we supply highly
reliable products manufactured under our GMPcompliant quality assurance system.

CustomManufacturing ofChemical Products

Advantagesof Custom
Manufacturing

Development, manufacturing
and commercialization incompliance with GMP standards○ BCP○ Avoidance of capital investment○ Cost saving in manufacturing○ Effective use of human resources

Our system is designed to meet various custom manufacturing needs.

Over many years we have been engaged in thedevelopment of pharmaceutical intermediates,
new pharmaceuticals and generics. As a partner toour customers, we provide custom manufacturingservices that take advantage of decades ofexperience as well as continuing support ofproducts that have already been commercialized.

Supplying to over 70 countries
and global expansion

Abundant experience withoverseas applications

V arious r egulations on pharmac eutic aldevelopment and manufacturing have beenformulated both in Japan and abroad. With ourknowledge of the regulatory requirements ofdifferent countries and marketing know-how
accumulated over many years of experience, we
supply APIs to more than 70 countries aroundthe world.

Even if a product complies with regulatory
requirements in Japan, the US and EU, additional
information and data is sometimes required. In
accordance with the customer’s product launchplan, the information that is required in eachcountry is identified, thus ensuring the successof the approval process.

Flow of Custom Manufacturing

We supply highly reliable products under a unique quality assurance system.
Inquiry / requestfrom a customer

Research anddevelopment

Pilot production

Custom Manufacturing

Support in filing
applications andcommercialization

Respond quickly andaccurately to a request
based on in-depth
communication.

Develop a GMP-compliant
development plan andpropose a manufacturingmethod, quality, costs, anddue date that are mostsuitable to the customer.

Produce a small volumeof the product on a trial
basis and discuss whatshould be improved
with the customer.

We mass produce
high-quality products
efficiently at the factory
to be delivered as
requested.

We provide support services infiling applications for approval ofdeveloped and/or manufactured
pharmaceutical products in linewith domestic and overseas
development plans, respectively.

Our Strengths
We first produce a small volume of products on a trial basis, and based on the customer’s assessmentof the prototype, identify where to improve. We then consider and draw up a plan for mass production
and commercialization. Based on the plan, we prepare for large-scale production using a highly efficientmanufacturing method. After receiving approval for the plan from the customer, we sign a contract
agreement and start high-quality mass production.

Development and Manufacturing Stages

Flow of Custom Manufacturing
Inquiry / requestfrom a customer

Pharmaceutical Intermediates, etc.

Research and development

In response to the customer's
wishes, we propose the mostsuitable manufacturing method,
quality, price, and delivery date.

Respond quickly and accurately
to a request based on in-depth
communication.

Pilot production

Custom manufacturing

Produce a small volume ofthe product on a trial basis
and discuss what should be
improved with the customer.

We mass produce high-quality
products efficiently at thefactory to be delivered as
requested.

Major manufacturing technology
Grignard reaction, esterification, alkylation, alkoxylation, acylation, amination, amidation, diazotization, condensation reactions, reductions, etc.
*We identify the optimal manufacturing method and manufacture products on a commercial scale under a quality control system that complies with ISO 9000.

APIs for Clinical Trials, etc.

Responsible Departments

Preliminary
development

Identifying an optimal synthesis route—

Research
Laboratory

Advanceddevelopment

Adjusting and improving the process

Disclosure of the manufacturing process,laboratory verification

Scale-up

Trial production
Establishing cGMP-compliant technology

Trial production
Establishing cGMP-compliant technology

Manufacturing
Technology
Department

Commercial
production

Validation

Validation

Quality
Assurance
Division

Manufacturing
Department

Major manufacturing technology
Grignard reaction, esterification, alkylation, alkoxylation, acylation, amination, amidation, diazotization, condensation reactions, reductions, etc.
*We identify the optimal manufacturing method, obtain approval for pharmaceutical manufacturing, prepare DMF, arrange registration, and manufacture products on acommercial scale under a quality control system that complies with GMP and ISO 9000.

Equipments[Major equipment(capable of complying with GMP)]

14

Equipment

Type

Size

NumberReactor

GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
GL
SUS
SUS
SUS
SUS
SUS
SUS
SUS

8,000L
6,000L5,000L
3,000L2,000L1,500L
1,000L
600L
500L
300L
200L
6,000L5,000L
3,000L
1,000L
600L
300L
150L

1
3
3
3
4
1
4
1
2
2
1
1
1
1
4
1
1
1

ReactorCentrifuge[Milling Facilities]  Pharmaceutical counter jet mills for ultrafine particles with a diameter of less than 10 µm are also available.
Equipment

Type

Hydrogenating pot

GL

Size
3,000L2,000L

Number1
1

Remarks
Hydrogen pressure: ≤ 1.0 MPa
Hydrogen pressure: ≤ 0.6 MPa

Crystallizer

GL,SUS

Several sizes—〜6,000L

Distilling pot

GL,SUS

Several sizes—〜6,000L
Distillate receivers, Dissolution tanks,
Sedimentation tanks, etc.

Vessels, etc.

GL,SUS

Several sizes—

Filter

GL,SUS

Several sizes—

Centrifuge—

Several sizes—

Discharge from top, Discharge frombottom, Full automation, Affron, SUS

Dryer

GL,SUS

Several sizes—

Vacuum tornado type, Conical type,Vibration and Fluid type

Clean room

—

—

4

Class 100,000

—

—

1

Pharmaceuticalwater manufacturing
equipment<Industrial-scale Machines>
Type

MachineJet mill

Hosokawa MicronCounter Jet Mill
200AFG-pharma

Jet mill

USP compatible<Small-scale Machines>
Specifications (nominal)

Hosokawa Micron
Spiral Jet Mill
200AS

Particle Size

Capacity/h

2~20µm20~30kg

1~5µm

10~30kg

Specifications (nominal)
Remarks

Type

MachineHammer mill

Hosokawa Micron
Fine Impact Mill
100UPZMedia: Nitrogen
400Nm3/hMedia: Nitrogen
400Nm3/hParticle Size

Capacity/h20~700µm

2~30kgRemarks

Plate beater
Hammer beater
Pin mill (3 kinds)<Specifications of the Milling Cleanroom>Class

100,000

Temperature

23±5℃

Moisture

45±15%

15

YUKI's History

Amino Acids, APIs andIndustrial Products from
YUKI to the WorldWe supply various kinds of chemical products in Japanand abroad through our sales network, with sales
offices in Tokyo, Osaka and Düsseldorf (Germany). For
the delivery of safe and reliable products throughout
the world, we use packaging containers appropriate foreach shipment and our storage methods and choice oftransport ensure the preservation of quality.

Düsseldorf

Tokyo
Osaka

(Million Yen) Export Sales

1947

●

YUKI GOSEI KOGYO CO., LTD. established as a tobacco
flavor producer

1952

●

Started manufacture of glycine, isoniazid andnicotinamide

1958

●

Started manufacture of β-alanine

1960

●

Started manufacture of 2-vinylpyridine

1962

●

Head Office moved to Takara-cho, Chuo-ku
Listed on the Tokyo Stock Exchange, Second Section

1963

●

Started manufacture of triacetin

1964

●

Started operation of Joban Factory
Started manufacture of flavors for Peace cigarettes

1965

●

Started manufacture of protamine sulfate and flavors formf cigarettes

1971

●

Started manufacture of glycine at new facilities

1975

●

Started manufacture of picolinic acid and intermediates
for agricultural chemicals

1978

●

Started manufacture of DNA
Activated sludge treatment facilities completed at Joban
Factory

1984●

Multi-purpose manufacturing facilities installed at Joban
Factory

1985●

Started manufacture of silicon-related products

1990

●

Pharmaceutical intermediate-purification facilities installed
at Joban Factory
Capital increased to 2,550 million yen

1991

●

Head Office moved to Hirakawa-cho, Chiyoda-ku
Manufacturing facilities for silicon and Grignard reagents
installed at Joban Factory

1995

●

Head Office moved to the current location
New building (Technology Development Center)completed at Joban Factory
DNA manufacturing facilities installed at Joban Factory

1996

●

Manufacturing facilities for 2-vinylpyridine moved from
Tokyo Research Laboratory to Joban Factory
Joban Factory certified with ISO 9002
Manufacturing facilities dedicated to silicon- and Grignardrelated products installed at Joban Factory
Capital increased to 3,471 million yen
Started manufacture of trifluorothymidine

1998

●

Head Office, Osaka Sales Office, Joban Factory and Tokyo
Research Laboratory certified with ISO 9001
Testing and research facilities for clinical trial drugs
installed at Joban Factory

1999

●

Certified with ISO 14001

2001

●

Started manufacture of Fudosteine "YUKI"
Subsidiary company Yuki Engineering Co., Ltd. renamed“YUKI TECHNO SERVICE CO., LTD.”
Pharmaceutical manufacturing facilities installed at Joban
Factory

2003●

Quality Control Building completed at Joban Factory

2004

●

Listed on the Tokyo Stock Exchange, First Section
Started operation of the Enterprise Resource Planning
System2006●

Düsseldorf Office established in Germany

2007

●

LNG conversion facilities completed

2012

●

Started manufacture of APIs for generics

2014

●

Cogeneration System introduced

2018

●

APIs and pharmaceutical intermediates manufacturing
facilities installed at Joban Factory

2021

●

Certified with FSSC 22000

2022

●

Changed to the Standard Market of the Tokyo Stock
Exchange

6000

5,737

5,709
5000
4000

5,108
4,029

3,877

4,303

3000
2000
1000
0

FY 2019 / 3

FY 2020 / 3

FY 2021 / 3

FY 2022 / 3

FY 2023 / 3

FY 2024 / 3

Locations

16

Head OfficeBusiness Division Ⅱ

Tokyo Research Laboratory

Joban Factory

Düsseldorf Office10-4, Nihonbashi-Ningyocho 3-chome,
Chuo-ku, Tokyo 103-0013
TEL : +81-3-3664-3980
FAX : +81-3-3664-3998

202 Kitade Building, 3-7, Awaji-machi
1-chome, Chuo-ku, Osaka 541-0047
TEL : +81-6-6229-8731
FAX : +81-6-6229-8732

37-1, Sakashita 3-chome, Itabashi-ku,
Tokyo 174-0043
TEL : +81-3-3967-7211
FAX : +81-3-3967-7576

788, Ochiai, Joban Nishigo-machi,
Iwaki-shi, Fukushima 972-8316
TEL : +81-246-42-4221
FAX : +81-246-44-2573

Oststraβe 152, 40210
Düsseldorf, Germany
TEL : +49-211-5665674
FAX : +49-211-5665675

17

Message from the President
YUKI GOSEI KOGYO has adopted since its founding a corporate philosophy of “We are dedicated toproviding products of the highest value to people by implementing innovative solutions.” and has
supplied safe and reliable products to people around the world through the development, manufacture,and sale of unique and valuable products that are based on state-of-the-art organic synthesis.
When we were founded 1947, we started with the industrialized production of naturally derived
sweeteners and became soon an established chemical manufacturer driven by science and advancing
technologies. In the following years, we developed a variety of new production lines in the fields Specialty
Chemicals, Amino Acids and Pharmaceuticals and expanded the business as R&D oriented company.
In recent years, we have carried out structural reforms in our historic amino acid business and areproceeding with the strengthening of the business foundation.
Moreover, we have expanded our healthcare-related product portfolio with an emphasis on
pharmaceuticals, and kept focused on structural reforms and new product development. This way, we
have established a well-balanced business structure in the three fields of amino acids, specialty chemicals
and pharmaceuticals. In the previous medium-term business plan, which started in 2020, we aimed toachieve management goals and deepen the business foundation.
In the current medium-term business plan, which has started in 2023, we are striving to improve ourcorporate value with the goal of achieving sales of 15 billion yen.
One of the key initiatives in this medium-term business plan is to foster a quality culture, because
products and services which satisfy customers depend not only on product quality, but also on the
beliefs and actions of the organization and individuals. We aim to improve the quality of daily work andthe profitability of our company. Improvements in our human capital had been already successful in theprevious mid-term plan and we will continue our efforts in this field in the future.
With the current medium-term business plan, we prioritize the improvement of corporate value,reformation of the business structures in the amino acids field, expanding contract business in thepharmaceutical field, and the expanding and restructuring of the specialty chemicals business. All these
initiatives are aimed at realization of the basic policy of the current medium-term business plan, “In arapidly changing economic environment, while expanding sales of key products, we will continue tointroduce new products and lay the foundation for growth over the next 10 years.” Through the mediumterm business plan, we aim to become a highly profitable company.
Another important topic is sustainability. We have begun to reduce our carbon dioxide emissions alreadyin the early 2000s years. However, as our business activities will continue to grow our possibilities tofurther reduce carbon dioxide emissions are limited.
As a new initiative, we have begun testing carbon-neutral fuels and 100% of the electricity supplied toour head office building is coming from renewable energy. We remain committed to reduce our carbon
dioxide emission by 50% until 2030.
We remain fully committed to responding to the expectations and trust of our stakeholders, byensuring the supply of products which help people to live healthier and enjoy more prosperous lives,and by protecting the environment for future generations, but also by increasing profits and actively
contributing to a better society.
We look forward to your continued support.

Corporate Philosophy

Corporate Mission

We endeavor to be a specialty

We are dedicated to providing

chemicals company through the

products of the highest value

utilization of our accumulated

to people by implementing

know-how and state-of-the-art

innovative solutions.

technologies.

Corporate Profile

Corporate Name

Organization Chart

YUKI GOSEI KOGYO CO., LTD.

General Meetingof Shareholders

OfficesHead Office, Business Division Ⅱ , Tokyo ResearchLaboratory, Joban Factory, Düsseldorf OfficeBusiness Fields○ Manufacturing and marketing of organic 		

Capitalsynthesis products and general chemical 		products○ Manufacturing and marketing of 		
pharmaceuticals, quasi-drugs, 			
pharmaceuticals for animal use, foods, food 		
additives, feed additives, industrial chemicals,
aroma chemicals, and cosmetics○ Marketing of raw materials and products
related to the above

Board ofDirectors

President

Business Administration
SectorAudit & Supervisory
Committee

General Affairs & Human
Resources Division

Audit Division

Accounting &Finance Division

Information
Systems Section

Purchasing
Division

Quality Assurance
SectionQuality Assurance
Division

Quality Control
SectionRegulatory Affairs
Section3,471 million yen

Responsible Care
Division(total number of issued shares: 21,974,000 shares)

Listed on the Tokyo Stock Exchange, Standard
MarketExecutives

Business
Administration Division

Business Sector

President & CEO
Business Sector

Business
Management Division
Business Division
Ⅰ

Seiichiro Matsumoto

Business Division

Düsseldorf
OfficeBusiness Division
Ⅲ

General Affairs
SectionResearch &Development Sector

Tokyo ResearchLaboratory

Research Section

Manufacturing
SectorJoban Factory

Intellectual Property
SectionDirector & Managing Executive Officer
Research & Development Sector
Manufacturing Sector

Ⅱ

Masahiro Kusano

Director & Senior Executive Officer
Business Administration Sector

Tatsuya Komatsubara

Director, Audit & Supervisory Committee Member

Naotake Suto

Manufacturing
Control Department

Director, Audit & Supervisory Committee Member

Keisuke Yamada
Norito Ohori

Senior Executive Officer, General Manager, Business
DivisionⅠ& Business Management Division

Affiliate Company
YUKI TECHNO SERVICE CO., LTD.

Manufacturing
Department Ⅰ

Packing Section
Processing
Section Ⅰ

Masao Matsukawa

Processing
Section Ⅱ

Executive Officer, General Manager, General Affairs &Human Resources Division

Hiromi Ishikawa

Power Supply &Sewerage Section

Executive Officer, General Manager, Joban Factory

Makoto Kito

Manufacturing
Department Ⅱ

Executive Officer, General Manager, Quality Assurance Division

Processing
Section Ⅲ
Processing
Section Ⅳ

Hiroshi Nakamura(as of June 21, 2024)

President & CEO
Number of
employees

290 (excluding loan, part-time and temporary

Major banks

MUFG Bank, Ltd., Joyo Bank, Mitsubishi UFJ Trustand Banking Corporation, Mizuho Bank, Ltd.

Subsidiary

18

Manufacturing
Control Section

General Affairs
Department

Director, Audit & Supervisory Committee Member

June 2024
YUKI GOSEI KOGYO CO., LTD.

Safety &Environment Section

employees)

YUKI TECHNO SERVICE CO., LTD.

(as of March 31, 2024)

Processing
Section Ⅴ
Control of Facilities
Department

Designing
Section
Maintenance
Section

Manufacturing
Technology Department

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