Small Molecule Preformulation

End old routines
Freeslate jr. automates all your hands-on, back and forth and hard to do small molecule
preformulation tasks. It ties them together and makes them one totally routine,
high-throughput process. Hand off the grunt work to freeslate jr., and hit the next big
thing on your plate instead.

• Solubility screening• Polymorph screening• Powder dispensing• Reaction screening

Hand off your process
Walk up, set up your run and walk away. Freeslate jr. automates the parts of your API
screening process you’d normally do one by one at the bench. Preconfigured decks forhigh-throughput solubility and polymorph screenings are ready to go when you are.
Examine more variables in a single day, get them done the same way every time andcheck out a broader developability and formulation space.

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Solvent tray
Position passive plate rack
3-Position passive plate rackSpray wash

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Heating/cooling/stirring
3-Position heating/stirring
Heated 4-tip liquid dispenser
Optional pH probeGet your crystals on
Give the number of crystalline forms you can characterize on your API a big-time boost
with freeslate jr.’s 8 x 12 array crystallization assembly. Heat or cool samples right on
the deck. The universal substrate lets you analyze samples by birefringence, XRD andRaman spectroscopy without wrecking a single crystal.

Crystallization assembly with
universal substrate plate

Integrated structural characterization by XRD

Stay soluble
Freeslate jr.’s temperature-controlled pipetting and filtering help get your API’s intosolution. Keep them from precipitating on you when you add or remove reagentsusing a heated dispense element with septum piercing tips for sealed vials. A heatedfilter block with 96 isolated sample wells erases any chance of well-to-well crosscontamination, so you can get the conditions just right.

Heated dispense elementwith septum-piercing tips

Crystallizer block for polymorph screeningGo sticky or solid
Spot-on pipetting, dispensing and weighing of viscous and solid materials means you’reaccurately evaluating your formulated drugs. Freeslate jr.’s positive displacement
pipetting handles the stickiest stuff out there — even at low volumes. Solid dispensers
use an adaptive learning algorithm to accurately dispense and weigh powders. They
also remember optimal settings so you get fast, reproducible dosing every time.

Viscous liquid
dispenser handles
up to 1000 cP

Classic Hopper
uses active stirring
for uniform flow rate

SV dispensers
use vibration for
precise delivery

Break through bottlenecks
LEA doesn’t move the bottleneck, it totally unclogs it. You get intuitive experimental designthat makes sense on the front end and full integration with analytical tools on the backend. LEA also links your conditions, steps and analytical data together, so your final reportdoesn’t just have numbers, it’s got all the information you need to make real decisions.

Library Studio
Design complex, high-throughput
experiments in an array-basedformatPolyView
Review and report all info
from experimental design,
execution and analytics

Automation Studio
Execute designed experiments
and integrated analytics

Unchained Labs
6940 Koll Center Pkwy, Suite 200
Pleasanton, CA 94566
Phone: 1.925.587.9800
Toll-free: 1.800.815.6384
Email: info@unchainedlabs.com© 2016 Unchained Labs. All rights reserved. The Unchained Labs logo and freeslate jr. are trademarks
and/or registered trademarks of Unchained Labs.