The 33rd Annual Scientific Meeting of theBritish Society of Toxicological Pathology (BSTP)
Pathology of Mouse Models of Disease
Thursday 15th & Friday 16th November 2018
MedImmune, Granta Park, Cambridge, UK

REGISTRATION IS STILL OPEN
AND WILL CLOSE AT MIDNIGHT ON SUNDAY 21st OCTOBER 201835.25 Royal Society of Biology CPD credits will be applied for
11.75 hours of educational activity will be recorded on AttendanceCertificatesIf you have any queries regarding this meeting, please contact the BSTP Secretariat bstpoffice@aol.com or visit the BSTP website:
http://www.bstp.org.uk/events/bstp-asm-pathology-of-mouse-models-of-disease/1Welcome
The BSTP's 33rd Annual Scientific Meeting (including the AGM) will cover the topic of mousepathology.
Based on the approach of previous mouse pathology meetings organised by the Wellcome
Trust in 2012, 2014 and 2016, this meeting will aim to have a mix of talks to enable those in
the early stages of their career to learn about pathology basics including terminology andnecropsy; the basics of necropsy approach and sample collection; collecting and handlingsamples and recording pathology data; commonly used mouse strains and commonphenotypes; infectious diseases that can affect phenotypes; planning for the unexpected ASPA. For more experienced pathologists, the aim is to enable you to refresh your knowledge
on the basics, whilst including talks on CRISPR/Cas9 technology; immuno-oncology andbiologic effects; and tissue based genetic studies.
•

Animal models in the age of CRISPR technology.

•

Animal models in oncology drug development.

•

Humanised mouse models in infectious disease research.

•Automated image analysis and artificial intelligence in pathology.

•Taking images for publication.

•Environmental effects on model phenotypes.

•A ‘toolkit’ for pathology – recognition of gross lesions, taking samples, fixatives,
special stains, RNAscope, tissue trimming and embedding, creating pathology data,INHAND, goRENI, comparative histopathology, comparative histopathology, strain
and age-related differences.

•The first day of the meeting will conclude with the Annual General Meeting of theBSTP.

Sponsorship and Promotional Opportunities
We feel that by participating in this conference it would allow your company to showcase arange of products to a diverse group of toxicological and experimental pathologists. Pleasecontact the BSTP at bstpoffice@aol.com more information.
IMPORTANT DEADLINES
Applications for Trainee/Early Career Pathologist places closes at midnight on Monday 31stJuly 2018
Early bird registration closes at midnight on Sunday 30th September
Registration closes at midnight on Sunday 21st October 2018
So, if you are you looking for some high quality CPD and would you like to broaden yourunderstanding on Pathology of Mouse Models of Disease then this is the meeting for you.
We hope to see you in November!

2Provisional Programme

08.15 - 08.4508.45 - 09.00
09.00 - 09.45
09.45 - 10.30
10.30 - 11.00

THURSDAY 15TH NOVEMBER 2018
REGISTRATIONWELCOME AND INTRODUCTION
Plenary: Automated image analysis and Artificial intelligence in pathology
Sami Blom, Aiforia, Finland
Plenary: Mouse models with humanised immune systems
Kourosh Saeb-Parsy, University of Cambridge, UK
REFRESHMENT BREAK AND ROOM CHANGE
Session 1:
Mouse Pathology 1-0-1(see notes on Page 4)

Session 2:
Animal models in oncology drug
development

11.00 - 11.45

Pathology basics
Ellie Ross, Crick Institute, UK

Overview of animal models of efficacy inoncology drug development
Jen Barnes, AstraZeneca, UK

11.45 - 12.30

Histology basics
Anne-Laure Bauchet, Sanofi Pasteur, France

Immunophenotyping of the tumour
microenvironment
Keith Mansfield, Novartis, Switzerland

LUNCH

12.30 - 13.30
13.30 - 14.00

Toolkit for pathology
Anne-Laure Bauchet, Sanofi Pasteur, France

Mass spec imaging in oncology drug
development
David Bonner, Imabiotech, France

14.00 - 14.30

Creating pathology data
Cheryl Scudamore, Envigo, UK`All in one lung’ model for NSCLC
Anderson Ryan, University of Oxford, UK

14.30 - 15.00

Recognising common pathology lesions
Elizabeth McInnes, Syngenta, UK

Discovery safety modelling of traditionalsafety endpoints for oncology agents
Teresa Collins, AstraZeneca, UK

15.00 - 15.30

REFRESHMENT BREAK

15.30 - 16.15

Comparative histopathology
Cory Brayton-Jones, Hopkins University ofMedicine, USA

In vivo imaging mouse models in oncology
drug development
Alan Wright, Cancer Research UK, UK

16.15 - 17.00

Common causes of (un)expected death inmice
Cory Brayton-Jones, Hopkins University ofMedicine, USA

BSTP Annual General Meeting3

08.30 - 08.55
08.55 - 09.00
09.00 - 10.00
10.00 - 10.30

FRIDAY 16TH NOVEMBER 2018
REGISTRATIONINTRODUCTION TO DAY 2
Plenary: Animal models in the age of CRISPR technology
Eckhard Wolf, Gene Centre, LMU Munich, Germany
General toxicity testing in animal models of disease – a regulatory perspective
David Jones, MHRA, UK
REFRESHMENT BREAK
Short Scientific Presentation:

10.30 - 11.00

Technology on the Pitch:
Short Scientific Presentation:
Technology on the Pitch:

11.00 - 12.00

Short Scientific Presentation:
Short Scientific Presentation:
Short Scientific Presentation:
12.00 - 13.00
13.00 - 13.45
13.45 - 14.30
14.30 - 15.00

LUNCHTitle – TBC
Speaker - TBC
The role of the microbiome in animal models
Azel Kornerup Hansen, University of Copenhagen, Denmark
REFRESHMENT BREAK

15.00 - 15.45

3D/MPS systems – are they the models of the future?
David Hughes, CN Bio Innovations, UK

15.45 - 16.00

Concluding remarks

Session 1 – Mouse Pathology Notes:
Pathology Basics: Why is pathology needed; basicsof necropsy; recognising and describing grosslesions; taking samples; fixing. With a particularfocus on preparation e.g. lung inflation, gut
sampling and which localisation e.g. prostate.
Histology Basics: Basic tissue trimming (RENI);
principles of correct localisation; orientation;amount of tissue; processing and embedding for
H&E histology; correct staining; pitfalls.
Toolkit for pathology: Use of different fixatives;frozen tissue; decalcification; use of special stains;
immuno; ISH; RNAscope etc.
Creating pathology data: Collecting and recording
pathology data; planning a study; appropriatecontrols; quantitative vs semiquantitative.

Recognising common pathology lesions: Basic
microscopic terminology; where to get theinformation i.e. INHAND, goRENI; common nonlethal background changes e.g. inflammation, focietc.
Comparative
histopathology:
Importantdifferences – mouse vs human; diseasesusceptibility and responses; related to strains;limitations.
Common causes of (un)expected death in mice:
Strain and age-related differences; common strains
e.g. C57BI6, BALBc.
You are advised that the programme timings,lecture title and speakers may be subject tochange without notice4Registration
Registration

Full meeting registration fee
Before 30th
After 30th
Sept 2018
Sept 2018£375.00£475.00£475.00£575.00£250.00
N/ADay delegate registration fee
Before 30th
After 30th
Sept 2018
Sept 2018£275.00£375.00£375.00£425.00£150.00
N/A

BSTP Member
Non-Member/Industry
Non-Member/Academic
Trainee/Early Career£200.00
N/A
N/A
N/A
Pathologist * see below* Trainee/Early Career Pathologists you are required to provide written confirmation of your statusfrom your Head of Department (on headed paper) when submitting your registration form.

THE EARLY REGISTRATION FEE WILL END AT MIDNIGHT ON SUNDAY 30th SEPTEMBER!
Full meeting registration fee includes: All scientific sessions including a USB flash drive
containing the meeting booklet; attendance certificate and refreshments during breaks andlight lunches on both days.
Trainee/Early Career Pathologist registration fee includes: All scientific sessions including a
USB flash drive containing the meeting booklet; attendance certificate and refreshments
during breaks and light lunches on both days.
Day delegate registration fee includes: All scientific sessions on the day booked including a
USB flash drive containing the meeting booklet; attendance certificate and refreshments
during breaks and a light lunch.
A list of the terms and conditions are available on the online registration form.
Registration for this meeting opened in May 2018 and will close on 21st October 2018.
Requests to attend will not be accepted after 21st October 2018.
Cancellation Policy: All requests for cancellations to bookings must be received in writing by
30th September 2018. Refund requests received up to 30th September 2018 will incur a 25%
processing fee. Refund requests received after 30th September 2018 will not be processed.
Those who cancel after 21st October 2018 and have not paid will be invoiced for the fullamount.
Replacements: Substitutions can be made at any time up to 21st October 2018.
If you have any queries, please contact:
BSTP Secretariat
BSTP │ PO Box 819 │ Harrogate │ North Yorkshire HG1 9XF │ UK
Tel:
Email:
Website:+ 44 (0)7894 123 533
bstpoffice@aol.com
www.bstp.org.uk

5

Trainee/Early Career Pathologist Opportunities
Are you a scientist working with mouse models of disease?

Pathology is an important tool for assessing disease induction in mouse models. This meeting will bedelivered by mouse pathology experts and is aimed at PhD Students, post-doctoral researchers, andprincipal investigators new to mouse models. Topics will include:•••••

How to perform a mouse post mortem
Recognising inflammation and cancer at post mortem and in tissues under the microscope
Sample collection and recording pathology data
Commonly used mouse strains and common phenotypes
Infectious diseases that can affect these phenotypes.

The scientific programme and plenary lectures of this meeting will also be covering some of theimportant scientific breakthroughs revolutionising mouse pathology including: CRISPR/Cas9technology; immuno-oncology and biologic effects; tissue based genetic studies, and will allow
networking opportunities with experienced mouse pathologists at this unique event.
The BSTP are delighted to offer 10 PhD students/residents the opportunity to attend (free of charge)
the full meeting (Thursday 15th and Friday 16th November 2018) or as a day delegate (on Thursday
15th November 2018 only). In addition, successful candidates will receive a year’s free membershipof the BSTP worth £60.
A prize (worth £100 and sponsored by PathCelerate Ltd) will be awarded to the best Scientific
Presentation given by a student/resident during the final morning session on the second day of themeeting.
Applicants must be stipendiary students studying a relevant mouse-model based PhD project, orpathology residents/trainees/early career pathologists working with mouse models.
All applications must be made by email to the BSTP Secretariat bstoffice@aol.com by midnight on
31st July 2018 with applications will be assessed by the BSTP Council on merit.
Successful applicants will be notified on or before 1st September 2018.
For more information including application requirements, please visit:
http://www.bstp.org.uk/events/bstp-asm-pathology-of-mouse-models-of-disease/

6Meeting Location
MedImmune
Milstein Building
Granta ParkCambridge CB21 6GHUK
Tel: + 44 (0)1223 471 471
Web: https://www.medimmune.com/about-us/cambridge-uk.html

BY ROADFor detailed road information via the M11 and A11 check your route using
http://www.bing.com/maps/
BY PUBLIC TRANSPORT
If you are travelling by train, contact the National
https://www.thetrainline.com/train-companies/national-rail

Rail

EnquiryLine-Granta Park provides two commuter bus services, one from Cambridge Train Station withstops at Hills Road and Addenbrookes’ Hospital, and one from Whittlesford Parkway Station.
Please click here for more information: http://www.grantapark.co.uk/park-life/travel/
BY AIR
Stansted Airport – 25.3 miles
London Heathrow Airport – 90.4 miles
Gatwick Airport – 80 miles
East Midlands Airport – 100.2 miles

7

Need somewhere to stay?
The cost of accommodation is NOT included in the registration fee; all delegates areresponsible for making their own travel and accommodation arrangements.
Cambridge is a popular tourist and conference destination. It is therefore advisable to bookaccommodation well in advance of your visit.
The Visitor Information Centre (http://www.visitcambridge.org/) can help with informationon accommodation and can book a place for you.
Details of hotels used by BSTP members attending previous events in Cambridge are as
follows:
Hotel du Vin & Bistro – http://www.hotelduvin.com/about-us/
The Best Western Gonville Hotel - http://www.gonvillehotel.co.uk/
The Lensfield Hotel - http://www.lensfieldhotel.co.uk/
The Royal Cambridge Hotel - http://www.theroyalcambridgehotel.co.uk/
The Arundel House Hotel - http://www.arundelhousehotels.co.uk/
Other hotels in the area:
Holiday Inn Express https://www.ihg.com/holidayinnexpress/hotels/gb/en/cambridge/cbgdk/hoteldetail?cm_mmc=GoogleMaps-_-EX-_-GB-_-CBGDKPremier Inn https://www.premierinn.com/gb/en/hotels/england/cambridgeshire/cambridge.html
Ibis –
https://www.accorhotels.com/gb/hotel-8548-ibis-cambridge-central-station/index.shtml
Alternatively, you can check hotel availability via the following links:
If you need to find other hotels in the area put LITTLE ABINGTON, CAMBRIDGE or DUXFORD
into a hotel search engine such as http://www.hotels.com or http://www.booking.com or
https://www.trivago.co.uk
Please don’t hesitate to contact bstpoffice@aol.com if you have problems finding a suitablehotel.

8Sponsors
There are a number sponsorship opportunities still available, if your company is interested inproviding sponsorship for this event, either financial or by the provision of delegate materials,
please contact the BSTP Secretariat as soon as possible – bstpoffice@aol.com

THIS COULD BE YOUR
COMPANY LOGO!

THIS COULD BE YOUR
COMPANY LOGO!

THIS COULD BE YOUR
COMPANY LOGO!

THIS COULD BE YOUR
COMPANY LOGO!

THIS COULD BE YOUR
COMPANY LOGO!

9Speed Networking and Mentor/Mentee Partnership
Building Event!
New to the industry?
Want to meet some new contacts or seek career advice?
Then come to the inaugural BSTP Speed Networking Event, to be held during this year’s
Annual Scientific Meeting.

Find out about different roles within the industry, how to prepare for exams, how to advanceyour career, and with whom to speak to take any mentor/mentee partnerships forward.
3-Minute Networking will be an opportunity to meet plenty of interested and engagedprofessionals in a short and fun period, enabling you to maximise your networking
opportunities.
More information will be available to those that register for this meeting.
Bring plenty of business cards!

10

From the A1(M) Jct 9

MedImmune Limited
Milstein Building, Granta Park, Cambridge, CB21 6GH, UK
Tel: +44 (0) 1223 471 471, Fax: +44 (0) 1223 471 472

Riverside