Workshop
1WBa June 24 (Mon) 9:00-11:30 (tentative)＜Session Language: English＞

Several oral presentations will be chosen from the free papers
Peptide-ligation based protein design
Organizers: Shinya Honda (AIST), Koki Makabe (Yamagata University)
Speakers: Koki Makabe (Yamagata Univ.), Takamitsu Miyafusa (AIST),
Yohei Sohma (The Univ. of Tokyo), Ryo Okamoto (Osaka Univ.),
Hidehiko Hirakawa (Tsukuba Univ.), Takuya Matsumoto (Osaka prefecture Univ)
Peptide ligation is a protein engineering technique that connects the backbone of two poly-peptide chains.
It expands the limitation of general recombinant protein expression, such as protein cyclization orincorporation of non-natural amino acids. In this workshop, we will discuss the broad perspective of thetechnique from chemical synthesis of peptides to intein/sortase ligation.

1WFa June 24 (Mon) 9:00-11:30 (tentative)＜Session Language: English＞

Several oral presentations will be chosen from the free papers
Structural, functional, and evolutionary analyses of transcription apparatus and RNA architecture
Organizers: Naruhiko Adachi (KEK), Hisashi Tadakuma (Osaka Univ.)
Speakers: Shun-ichi Sekine (RIKEN), Kayo Nozawa (The Univ. of Tokyo), Naruhiko Adachi (KEK),
Hisashi Tadakuma (Osaka Univ.), Tomohiro Yamazaki (Hokkaido Univ.)
RNA regulates numerous biological phenomena. Recent evidence suggests that RNA forms membranelessstructures in vivo, which are functionally associated with transcriptional activity. Here, we present studies
on the structure, function, and evolution of the transcription apparatus and RNA architecture. We will
discuss the connection between cell biology and protein science through RNA function.

1WGa June 24 (Mon) 9:00-11:30 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Cross-talk between structural biology and synthetic biology of natural products biosynthesis
Organizers: Shingo Nagano (Tottori Univ.), Tomohisa Kuzuyama (The Univ. of Tokyo)
Speakers: Haruo Ikeda (Kitasato Univ.), Chitose Maruyama (Fukui Prefectural Univ.),
Osami Shoji (Nagoya Univ.), Ayako Yoshida (The Univ. of Toky),
Shingo Nagano (Tottori Univ.)
To date, X-ray crystallography has revealed the structures of numerous enzymes involved in thebiosynthesis of natural products; this has led to great advances in this field. Natural product biosynthetic
pathways provide important targets for synthetic biology-based studies because of their complexity andthe modular structure of the natural product biosynthetic machinery. We would like to discuss a novel
strategy for the biosynthesis of natural products through a combination of structural and synthetic
biology-based techniques.

1WBp June 24 (Mon) 16:45-19:15 (tentative)＜Session Language: English＞

Several oral presentations will be chosen from the free papers
Current status and issues of biopharmaceuticals from the view points of protein science and regulatory
scienceOrganizers: Susumu Uchiyama (Osaka Univ.), Akiko Ishii (National Institute of Health Sciences)
Speakers: Hiroko Shibata (NIHS), Shinaya Honda (AIST),
Satoshi Saitoh (Chugai Pharmaceutical Co., Ltd.), Satoru Nagatoishi (The Univ. of Tokyo),
Elena Krayukhina (U-Medico Inc.)
Though the therapeutic proteins have been widely used recently, further studies on the protein stability
and immunogenicity are necessary for developing therapeutic proteins with higher quality and safety. In
this session, we will focus on the current status of therapeutic proteins from the viewpoints of protein andregulatory sciences.

1WCp June 24 (Mon) 16:45-19:15 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Towards next generation computational drug discovery
Organizers: Hiroki Shirai (Astellas Pharma Inc.), Mitsunori Ikeguchi (Yokohama City Univ.)
Speakers: Masateru Ohta (Riken), Masataka Kuroda (Mitsubishi Tanabe Pharma),
Kengo Kinoshita (Tohoku Univ.), Daisuke Kuroda (The Univ. of Tokyo),
Mitsunori Ikeguchi (Yokohama City Univ.)
There is an increasing level of research in in silico technologies for drug discovery. However, complex
nature of molecular recognition still prevents us from establishing ideal "in silico drug discovery." In thisworkshop, we will capture the current status, problems, and future aspects of this field from thepresentations and discussions by the renowned speakers from academia and industry.

1WFp June 24 (Mon) 16:45-19:15 (tentative)＜Session Language: English＞

Several oral presentations will be chosen from the free papers
Organelle Zone: Compartmentalized organelle structure and function
Organizers: Satoshi Goto (Rikkyo Univ.), Yasushi Tamura (Yamagata Univ.)
Speakers: Satoshi Goto (Rikkyo Univ.), Yasushi Tamura (Yamagata Univ.),
Kazunori Imaizumi (Hiroshima Univ.), Takumi Koshiba (Kyushu Univ.),
Masatoshi Yamamoto (Kumamoto Univ.)
Recent studies have revealed the existence of “organelle zones” that are functionally and structurally
specialized organelle regions. In this workshop, we will introduce our recent findings of the organelle
zones and discuss the latest pictures of organelles.

1WGp June 24 (Mon) 16:45-19:15 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Cooperative regulation of cellular functions by bio-metals and proteins
Organizers: Yoshiaki Furukawa (Keio Univ.), Taiho Kambe (Kyoto Univ.)
Speakers: Tomonori Tamura (Kyoto Univ.), Masato Yasui (Keio Univ.), Satoshi Watanabe (Tohoku Univ.),
Ayako Fukunaka (Gunma Univ.), Kouhei Tsumoto (The Univ. of Tokyo)

Various physiological processes are realized by well-organized collaboration between metal ions andproteins in vivo. Breakdown of such collaborative actions will thus result in diseases. In this WS,
relevance of metal ions in our physiologies as well as pathologies will be discussed from various
perspectives including chemical, biological, and medical points of view.

2WFa June 25 (Tue) 8:45-11:15＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
The new horizon of the multiple transmembrane proteins －These structures, multiple functions and newtechnologies－
Organizers: Kosei Takeuchi (Aichi Medical Univ.), Atsushi Tamura (Osaka Univ.)
Speakers: Atsushi Tamura (Osaka Univ.), Shun Nakakmura (Nagoya Univ.),
Masayasu Kojima (Kurume Univ.), Takeshi Murata (Chiba Univ.),
Yoshito Takeda (Osaka Univ.),Hiroyuki Sasakuraa (Aichi Medical Univ.),
The purpose of this workshop is trying to unify the latest studies of GPCR, Tetraspanin and claudin family,
to discover clues and elucidate the molecular structure and functions of these multiple transmembraneproteins.

2WGa June 25 (Tue) 8:45-11:15＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Biology of state transition of proteins
Organizers: Kozo Tanaka (Tohoku Univ.), Yasushige Yonezawa (Kindai Univ.)
Speakers: Masanori Ikeda (Tohoku Univ.), Takuma Shiraki (Kindai Univ.),
Kota Kasahara (Ritsumeikan Univ.), Kazuko Okamoto (RIKEN ),Motonori Ohta (Nagoya Univ.), Akihiko Muto (Tohoku Univ.)
The nature of protein function is supposed to exist in state transition originating from the fluctuation ofprotein structure, rather than the structure itself. In this workshop, we will reconsider the protein function
through cell-biological, macro to micro viewpoint as well as structural biological, micro-to-macro
viewpoint, to decipher the biological mission of protein.

2WCp June 25 (Tue) 16:30-19:00＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Capturing proteins in action〜a new era of investigating protein structural dynamics
Organizers: Eriko Nango (RIKEN), Tomoya Hino (Tottori Univ.)
Speakers: Toshiaki Hosaka (RIKEN), Daisuke Sato (Soka Univ.), Yasuhiro Matsunaga (RIKEN),
Hiroshi Nishimasu (Univ. of Tokyo), So Iwata (Kyoto Univ./RIKEN),
There is a limit in interpreting protein function based on a protein structure in a static state because
structural changes occur in a protein at work. Therefore, a study of protein dynamics is expected as next
generation structural biology. In this workshop, we present the latest results of the studies of protein
dynamics performed using X-ray free electron lasers, atomic force microscopy, time-resolved X-ray
solution scattering, or molecular simulation.
2WFp June 25 (Tue) 16:30-19:00＜Session Language: English＞

Several oral presentations will be chosen from the free papers
Protein scientific approaches for understanding mitochondrial functions
Organizers: Takumi Koshiba (Kyushu University), Koji Okamoto (Osaka University)
Speakers: Koji Okamoto (Osaka Univ.), Miyu Moriyama (The Univ. of Tokyo),
Non Miyata (Kyushu Univ.), Satoko Arakawa (Tokyo Medical and Dental Univ.),
Daniel Ken Inaoka (Nagasaki Univ.),
The mitochondrion, a double-membraned organelle, is the powerhouse of eukaryotic cells which plays animportant role in generating ATP and controlling calcium levels. Recent genetic studies in many model
species have demonstrated that mitochondria are not just limited to respiration and apoptosis. In thissymposium, we invited domestic young investigators, and they will discuss about current topics
regardinge new aspects of mitochondrial functions and we would like to share this knowledge to get to
the next stage of mitochondrial studies.
2WGp June 25 (Tue) 16:30-19:00＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
A brand-new way of collaboration; Cell biology x Protein science
Organizers: Sakane Ayuko (Tokushima University), Tsuchiya Yuko (AIST)
Speakers: Sakane Ayuko (Tokushima Univ.)-Tsuchiya Yuko (AIST), Takei Kohji (Okayama Univ)Uchihashi Takayuki (Nagoya Univ), Katagiri Toyomasa (Tokushima Univ.)Mizuguchi Kenji (NIBIOHN), Sato Miyuki (Gunma Univ.)-Kosako Hidetaka (Tokushima Univ.)
Mutual cooperation between cell biology and protein science is indispensable for understanding of thepathogenesis of diseases from the viewpoint of protein structure, protein-protein interplay, and protein
modification in the dysregulation of multiple cellular functions. In this workshop, a cell biologist and aprotein scientist give a talk in pairs on a brand-new way of collaboration to achieve their goal.

3WCa June 26 (Wed) 8:45-11:15 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Maintenance and Dysregulation of Homeostasis in Living Organisms
Organizers: Ari Hashimoto (Hokkaido Univ.), Chitose Oneyama (Aichi Cancer Ctr. Res. Inst.)
Speakers: Ohtani Naoko (Osaka City Univ.), Yusuke Ohba (Hokkaido Univ.),
Yoshihiro Omori (Osaka Univ.), Chitose Oneyama (Aichi Cancer Ctr. Res. Inst.),Ari Hashimoto (Hokkaido Univ.)
Multicellular organisms maintain their homeostasis via intricate and sophisticated mechanisms that
operate intracellular/intercellular signaling to respond to various environmental factors. In this workshop,
we will focus on recent data regarding the associations between signals of homeostatic maintenance, as
well as diseases resulting from its dysregulation, to deepen our understanding of the molecularmechanisms underlying the diversity/universality of dysregulated homeostatic maintenance.

3WDa June 26 (Wed) 8:45-11:15 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Protein Science Society Archive WS : Joint use facilities to expand research activity of protein science –From “How to use” to latest technologies
Organizers: Tomoki Matsuda (Osaka University), Maho Yagi (ExCELLS)
Speakers: Yusuke Yamada (KEK), Nobutaka Shimizu (KEK), Takashi Kumasaka (JASRI),
Takanori Kigawa (RIKEN), Koichi Kato (ExCELLS), Kaoru Mitsuoka (Osaka Univ.)
In this workshop, joint research facilities related to the protein science are introduced by the researchers
managing them. Aiming at a broad audience, topics of their talk covers from utilization procedure tocutting-edge technologies. We hope audiences to take back useful information to overcome one's
limitations of research by using these outstanding facilities.

3WGa June 26 (Wed) 8:45-11:15 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Understanding the signal transduction mechanisms of 1TM receptors based on the molecular and cellulardynamics
Organizers: Terukazu Nogi (Yokohama City Univ.), Yasushi Sako (RIKEN)
Speakers: Terukazu Nogi (Yokohama City Univ.), Yasushi Sako (RIKEN),
Umehar Ohto (The Univ. of Toky), Shuya Fukai (The Univ. of Toky),
Hiroshi Hanafusa (Nagoya Univ.)
Single-pass transmembrane (1TM) receptors constitute a large family in the cell surface proteins andexhibit pleiotropic functions in eukaryotic cells. This workshop will showcase some advances in research
to elucidate the mechanisms of receptor activation and signal transduction from the viewpoint ofmolecular and cellular dynamics.

3WCp June 26 (Wed) 13:50-16:20 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Phase Separation Biology
Organizers: Kentaro Shiraki (Univ. of Tsukuba), Akira Matsuura (Chiba Univ.),
Takeshi Noda (Osaka Univ.)
Speakers: Kentaro Shiraki (Univ. of Tsukuba), Masahiro Mimura (Univ. of Tsukuba),
Tatsuya Maeda (Hamamatsu Univ. School of Medicine.), Hisao Moriya (Okayama Univ.),
Tomoshi Kameda (AIST), Takuya Yoshizawa (Ritsumeikan Univ.),
Eiichiro Mori (Nara Medical Univ.)
The concept that liquid-liquid phase separation is one of the organizing principles for cells has emerged,
which makes a great impact on the fields of protein science and cell biology. In this workshop scientists
studying the topics related to “Phase Separation Biology” will gather to discuss recent advances andfuture direction of this field.

3WDp June 26 (Wed) 13:50-16:20 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Toward rational design of protein crystals
Organizers: Naoki Kunishima (Rigaku Corporation/RIKEN), Kentaro Tomii (AIST)
Speakers: Naoki Kunishima (Rigaku Corp./RIKEN), Megumi Kosaka (Okayama Univ.), Miki Senda (KEK),
Ryuji Tanimura (Toray Inds.), Shou Maki (Osaka Ohtani Univ.),
Kazunori Yamada (Tohoku Univ.)
Although the protein crystallography is a major tool for the structural biology, obtaining suitable crystals
for the structure determination has not yet been straightforward. In this workshop, the rational design ofprotein crystals and the other technologies that resolve the crystallization problem will be introduced andwill be discussed.

3WEp June 26 (Wed) 13:50-16:20 (tentative)＜Session Language: English＞

Several oral presentations will be chosen from the free papers
Computer simulations of protein-protein and protein/DNA interactions in celluar environments
Organizers: Yuji Sugita (RIKEN), Takaharu Mori (RIKEN)
Speakers: Chales Brooks III (Univ. of Michigan), Wataru Shinoda (Nagoya Univ.),
Wonpil Im (Lehigh Univ.), Giovanni Brandani (Kyoto Univ.),
Michael Feig (Michigan State Univ.), Yuji Sugita (RIKEN)
Recent progress of supercomputers have allowed us to study large biological systems, such as biologicalmembrane, membrane proteins, crowding in the cytoplasm, virus, nucleosome, and chromatin, bycomputer simulations. In these simulations, it is essential to investigate interactions between multiple
biomolecules for understanding biological functions in cellular environments. We show new insightobtained by computer simulations and discuss collaboration with experiments.

3WFp June 26 (Wed) 13:50-16:20 (tentative)＜Session Language: Japanese＞

Several oral presentations will be chosen from the free papers
Coalition between measurement and information to investigate biomolecular structure and function
Organizers: Sotaro Fuchigami (Kyoto Univ.), Yasuhiro Matsunaga (RIKEN)
Speakers: Kazuyuki Nakamura (Meiji Univ. / JST PRESTO), Takuma Kasai (RIKEN),Miwa Sato (Mitsui Knowledge Industry), Sotaro Fuchigami (Kyoto Univ.)

By combining various experimental measurements with state-of-the-art techniques of information sciencesuch as simulation, AI, and machine learning, it is becoming possible to investigate the structure andfunction of biomolecules in unprecedented detail. This workshop aims to overview the latest
developments in such combined methods, and to discuss the usefulness and limitations of these methods.