i-Newsletter2023winterTransmit KING SKYFRONT latest information at
BioJapan 2022

Kawasaki Institute of Industrial Promotion booth

BioJapan2022, Asia's largest partnering event in the bioindustry, was held at Pacifico Yokohama from October
12th to 14th, 2022. It attracted more than 16,000 visitors
over the three days, with many domestic and international
companies and research institutions.
The Kawasaki Institute of Industrial Promotion (KIIP)
exhibited at the "Yokohama Kawasaki Pavilion" andintroduced KING SKYFRONT and their initiatives forincubation projects. In the same pavilion, otherinstitutions located in KING SKYFRONT, such as theCentral Institute for Experimental Animals, Elixagen
Scientific, Inc., Natural Materials Exploration LaboratoryCo., Ltd., Innovation Center of Nanomedicine, etc. also
participated as well. There was an active interaction
among domestic and overseas life science clusters andacademia.
On the first day of the event, we shared the latest
information on KING SKYFRONT with Shimadzu
Corporation and JSR Corporation in the presentation area.
The theme was "~Kawasaki's southern tip is the world's
most advanced~ Challenge of the ever-evolving KINGSKYFRONT".

SHIMAZDU Corporation Analysis and Measurement
Division SAITO Hiroomi

JSR Corporation Head of Life Science Corporate R&Dand Head of JSR Bioscience and informatics R&D center
HASHIMOTO Hideo

At the Shimadzu Tokyo Innovation Plaza, which is about toopen, Mr. Saito of the Business Planning Department of theAnalytical & Measuring Instrumentation Division talked
about the goals at the KING SKYFRONT, including thedevelopment of applications to solve social issues and thefostering of collaborative networks by utilizing theresearchers' exchange area in the facility.
The JSR Bioscience and informatics R&D center (JSRBiRD) which opened in KING SKYFRONT last year
is also one of the research centers and creating new
businesses by life science and informatics. Mr. Hashimoto
introduced the concept of working on research anddevelopment while interacting with researchers with various
backgrounds, and he said that the collaborations with startup companies began. In addition, the Kawasaki Institute ofIndustrial Promotion summarized the accumulation
situation of KING SKYFRONT, the incubation businessand the share office which have started this year.
This event was very successful that future development andgrowth of KING SKYFRONT can be anticipated byeveryone who visited.

Holding “PhRMA Translational Research Symposium”
at KING SKYFRONTOn November 26th, 2022, the PhRMA Translational Research Symposium Japanese Seeds and Human Resources nurtured in Kawasaki, Kanagawa - ofPharmaceutical Research and Manufacturers of America (PhRMA) was held atKING SKYFRONT. In this symposium, the scientists in medical field who arefrom industry, government and academia discussed from various perspectives
on theme such as discovering and cultivating seeds. It aimed to further increase
the participants' motivation for research, as well as how to develop humanresources who can play an active role globally in the field of drug discovery. Onthe day, as keynote speeches, Mr. KOJIMA Nobuhiko, Director and CTO ofEcocell Co., Ltd., talked about his experience in starting a university venture,and Dr. SHIMAOKA Mikiko, Professor, Graduate School of Health Innovation,
Kanagawa University of Health and Welfare, spoke about the methods andtheory which are necessary for startups.

Mr. KOJIMA Nobuhiko, CTO Ecocell Co.

In the panel discussion in the last partof the symposium, there was an active
discussion towards the development ofJapan’s drug discovery ecosystem.

Metcela has been selected for AMED projects
worth up to 1 billion yen

Kao Announces the outcome of virus
research using VHH antibodies

Metcela Inc., has announced that they have been selected for
AMED’s “CiCLE：specifically called ViCLE for start-up company”.
In this adopted project, they will promote collaboration with
Okayama University for regenerative medicine products that Metcela
is developing and will work on the development of therapy forpatients with monoventricular disease that is pediatric congenital
single ventricle. Under the mission of "Revolutionizing the treatmentof heart failure", Metcela is conducting research with the aim ofproviding new regenerative medicine products centered on heart
failure.
Attention is focused on the development of hopeful treatments forpatients with limited treatment options.

Household Products ResearchLaboratories, Kao Corporation, RIKEN,
Kitasato University and Epsilon MolecularEngineering Inc. has discovered a simple
method for visualizing SARS-CoV-2
attached to textiles using a VHH antibodyfluorescent protein fusion. This researchachievement will help understand detailed
localization of viruses in the environmentand develop products for inactivating andremoving viruses.

Click here for Metcela Corporation news release

Make more effective by breaking the shield of refractory cancers
Refractory cancers such as triple negative breast cancer (TNBC) develop fibrous tissues
called stroma, which is like an energy shield covering alien’s spaceships, repellingexternal attacks such as immune cells and anticancer drugs. Some studies are underway
to weaken the stroma to make immunotherapy and chemotherapy more effective.
Focusing on the fact that the long-listed antiallergic drug "Tranilast" remodels
proliferating fibrous tissues, a Tranilast-loaded nanomachine was administered to TNBC
model mice. As a result, the stroma was weakened with 100-fold reduced amount ofTranilast used without micellization, and the disappearance of tumors and retention ofimmunity were observed when used in combination with anticancer agents. The results
are shown in Nature Communications on November 22.

Do you know KING SKYFRONT ?
Tonomachi KING SKYFRONT is located on the opposite bank of
Haneda International Airport across the Tama River, and is
Tonomachi International Strategic Zone in the life science fieldthat creates new industries from world-class research anddevelopment. Around 70 institutions are gathered on a 20-hectare
site, where research and other activities are conducted on a daily
basis.
Please come and see the charm of the KING SKYFRONT.

Click here

Click here for this treatise

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Date of issue: February 2023
Publisher:
TONOMACHI LifeScience Cluster Division,
Kawasaki Institute of Industrial Promotion
Mail：info-ksfcl@kawasaki-net.ne.jp