PRODUCT INFORMATION
Cannabidiol (exempt preparation)
Item No. 90081

CAS Registry No.: 13956-29-1
Formal Name:
2-[1R-3-methyl-6R-(1methylethenyl)-2-cyclohexen-1yl]-5-pentyl-1,3-benzenediol
Synonym:
CBD
MF:
C21H30O2
FW:
314.5
Purity:≥99%
Stability:≥1 year at -20°C
Supplied as:
A solution in methanol
UV/Vis.:λmax: 209, 275 nm

OHHO

Laboratory Procedures
For long term storage, we suggest that cannabidiol (exempt preparation) be stored as supplied at -20°C. It
should be stable for at least one year.
Cannabidiol (exempt preparation) is supplied as a solution in methanol. To change the solvent, simply
evaporate the methanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Solvents such as ethanol, methanol, DMSO, and dimethyl formamide purged with an inert gas can beused. The solubility of cannabidiol (exempt preparation) in these solvents is approximately 35, 30, 60, and
50 mg/ml, respectively.
Cannabidiol (exempt preparation) is sparingly soluble in aqueous buffers. For maximum solubility inaqueous buffers, cannabidiol (exempt preparation) should first be dissolved in DMSO and then diluted withthe aqueous buffer of choice. Cannabidiol (exempt preparation) has a solubility of 250 µg/ml in a 1:3 solutionof DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for morethan one day.
Description
Cannabidiol is an active phytocannabinoid identified in Cannabis (composes ~40% of the plant’s extract).
Unlike Δ9-THC (Item No. 12068), cannabidiol is considered to be non-psychoactive.1 Cannabidiol has a very
low affinity for CB1 and CB2 receptors but acts as an indirect antagonist and is thought to potentiate theeffects of Δ9-THC.2 Cannabidiol is reported to act as a CB2 receptor inverse agonist, GPR55 antagonist,and a 5-HT1A receptor agonist.2-5 It can allosterically modulate μ- and δ-opioid receptors as well as agonize
PPARγ receptors and stimulate intracellular calcium release.6,7
References
1. Kozela, E., Juknat, A., Kaushansky, N., et al. J. Neuroinflamm. 12(52), (2015).
2. Mechoulam, R., Peters, M., Murillo-Rodriguez, E., et al. Chem. Biodivers. 4, 1678-1692 (2007).
3. Pertwee, R.G. Br. J. Pharmacol. 153(2), 199-215 (2008).
4. Ryberg, E., Larsson, N., Sjögren, S., et al. Br. J. Pharmacol. 152, 1092-1101 (2007).
5. Russo, E.B., Burnett, A., Hall, B., et al. Neurochem. Res. 30(8), 1037-1043 (2005).
6. Campos, A.C., Moreira, F.A., Gomes, F.V., et al. Phil. Trans. R. Soc. B. 367, 3364-3378 (2012).
7. Kathmann, M., Flau, K., Redmer, A., et al. Naunyn-Schmiedeberg’s Arch. Pharmacol. 372(5), 354-361 (2006).

WARNINGTHIS PRODUCT IS FOR RESEARCH ONLY - NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
SAFETY DATAThis material should be considered hazardous until further information becomes available. Do not ingest, inhale, get in eyes, on skin, or on clothing. Wash thoroughly afterhandling. Before use, the user must review the complete Safety Data Sheet, which has been sent via email to your institution.
WARRANTY AND LIMITATION OF REMEDY
Buyer agrees to purchase the material subject to Cayman’s Terms and Conditions. Complete Terms and Conditions including Warranty and Limitation of Liability information
can be found on our website.
Copyright Cayman Chemical Company, 08/17/2015

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