MOUSE STRAIN DATASHEET - 004297

B 6 . C X PB d1 e- 6rd10b/ JFA CULTYSTRA IN

Stock No: 004297
 Congenic,Spontaneous Mutation

AVAILABILITY VARIESC O N T A C T

C U S T O M E R

S E R V I C E

 Overview
Retinal degeneration 10 (rd10) is a spontaneous missense point mutation in Pde6b (cGMP phosphodiesterase 6B, rod receptor,
beta polypeptide). Although similar to rd1, the rd10 phenotype has a later onset and milder retinal degeneration and may provide abetter experimental drug therapy model for retinitis pigmentosa.
R E A DGENETIC OVERVIEW

M O R E+Genetic Background

Generation

000664 C57BL/6J

N6F8(2016-12-29 00:00:00)

Pde6brd10
Allele Type

Gene Symbol

Gene Name

Spontaneous

Pde6bphosphodiesterase 6B, cGMP, rod receptor, beta polypeptide

V I E WG E N E T I C S

A L L

R E S E A R C H

RESEARCH APPLICATIONS
Sensorineural Research
V I E W

A P P L I C A T I O N SBASE PRICE
Starting at:$151.83 Domestic price for female

V I E WP R I C E

L I S T Details
 Detailed Description

Pde6b (cGMP phosphodiesterase 6B, rod receptor, beta polypeptide) encodes the beta subunit of phosphodiesterase (PDE), aperipheral membrane enzyme involved in the phototransduction cascade in rod photoreceptors. Mutations in PDE are associatedwith retinitis pigmentosa and night blindness. Mice homozygous for retinal degeneration 10 (rd10) exhibit sclerotic retinal vessels at
4 weeks of age, progressive retinal outer nuclear layer degeneration beginning at 16 days, and a progressive decline in rod andcone ERG a- and b- waves. Retinal degeneration is delayed by approximately a week in mice raised in total darkness.
Although similar to rd1, the rd10 phenotype has a later onset and milder retinal degeneration and may provide a better experimental
drug therapy model for retinitis pigmentosa.
 Development
 Control Suggestions

 Genetics
 Pde6brd10

 Disease/Phenotype

 Disease Terms
 Research Areas By Genotype
 Mammalian Phenotype Terms by Genotype
 References Technical Support
T E C H N I C A L

C O N T A C TS
U P P O R T

T E C H N I C A L

C H A TS U P P O R T

Genotyping Protocols

Sanger sequencing:Pde6brd10
Genotyping resources and troubleshooting

Mating System
Homozygote x Homozygote

Appearance
blackRelated Genotype: a/aCitation

rd10

When using the B6.CXB1-Pde6b /J mouse strain in a publication, please cite the originating article(s) and include JAX stock
Animal Health Reports#004297
in yourLevel
Materials
and Methods section.
Facility Barrier
Descriptions
 MGL277 (Low) Pricing & Availability

Availability
VariesDomestic International
Pricing effective for USA, Canada and Mexico shipping destinations

Live Mouse
AGESEXApprox 4-8 weeks

GENOTYPE

FemaleHomozygous for Pde6b

Male

Homozygous for Pde6b

Related Products and Services

PRICErd10
rd10$151.83$151.83

Frozen Mouse Embryo

B6.CXB1-Pde6b<rd10>/J Frozen Embryos$2595.00

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