第 3 日目

12 月 3 日（金）第3日目12月3日（金）3AS-01Room 01 (Pacifico Yokohama Conference Center, 1F, Main Hall)

9:00-11:15【E】

Continuity of the life and Aging
Organizers：Takehiko Kobayashi（The University of Tokyo）
Akiko Takahashi（Cancer Institute）

3AS-01-Introduction

【9:00】

Takehiko Kobayashi（The University of Tokyo）

3AS-01-1

【9:04】The budding yeast, as a model for aging study

Takehiko Kobayashi（Inst. for Quant. Biosci. (IQB), Univ. of Tokyo）

3AS-01-2

【9:24】

Molecular mechanisms underlying organismal lifespan regulation in C. elegansMasaharu Uno, Masanori Nono, Emiko Okabe, Saya Kishimoto, Chika Takahashi, Eisuke Nishida（RIKEN BDR）

3AS-01-3

【9:49】

Novel regulatory mechanism of SASP in cellular senescence
Akiko Takahashi（Proj. for Cell. Senes., Cancer Inst., JFCR）

3AS-01-4

【10:14】

Mechanisms of ribosomal DNA maintenanceYamashita M. Yukiko1,2, George J. Watase1,2, Jonathan O. Nelson1,2（1Whitehead Institute for Biomedical Research/MIT, 2Howard
Hughes Medical Institute）

3AS-01-5

【10:44】

Achieving Productive Aging: The Systemic Regulatory Mechanism of Mammalian Aging and Longevity and Anti-Aging
Intervention
Shin-ichiro Imai（Dept. of Dev. Biol. and Med. Washington U. Sch. Med.）

3AS-01-Conclusion

【11:14】

Akiko Takahashi（Cancer Institute）

3AS-02

Room 02 (Pacifico Yokohama Conference Center, 3F, 301)

9:00-11:15【E】

Physical properties of biomolecules in human life and diseases
Organizers：Fumiyo Ikeda（Kyushu University）
Makoto Kinoshita（Nagoya University）

3AS-02-Introduction
Fumiyo Ikeda（Kyushu University）

3AS-02-1

【9:00】【9:03】

Regulation of cellular stress responses by stress granule formation

Mutsuhiro Takekawa（Div. of Cell Sig. & Mol. Med., Inst. of Med. Sci., Univ. of Tokyo）

3AS-02-2

【9:23】

Modification of physical properties and reconstruction of postsynaptic density by liquid-liquid phase separation

1 1
Tomohisa Hosokawa1, Pin-Wu Liu2, Makoto Kinoshita（
Dept. of Mol. Biol., Grad. Sch. of Sci., Nagoya Univ., 2Grad. Sch. of Med., KyotoUniv.）

3AS-02-3

【9:43】

Global interactome analysis in living cells using advanced proteomic technologies
Hidetaka Kosako（Inst. Adv. Med. Sci., Tokushima Univ.）

3AS-02-4

【10:03】Comprehensive identification of novel interactors of viral RNA receptor MDA5 based on in vitro and cell-based interactionassays

1 1
Hirotaka Takahashi1, Shion Sakaguchi1, Norihiro Hayashi1, Takashi Irie2, Hidetaka Kosako3, Tatsuya Sawasaki（PROS，Ehime Univ.,
23Dept. of Virol., Institute of Biomed. & Health Sci., Hiroshima Univ., Inst. of Adv. Med. Sci., Tokushima Univ.）

3AS-02-5

【10:23】

A novel LUBAC-bidning protein plays important role in response to parasite infection

Yuri Shibata, Sachin Khurana, Niccolay Madiedo Soler, Ethan Goddard-Borger, Chris Tonkin, David Komander（WEHI）

The 44th Annual Meeting of the Molecular Biology Society of Japan

13

第 3 日目

12 月 3 日（金）3AS-02-6

【10:43】Cellular functions regulated by complex-type ubiquitination including linear polyubiquitin chain

Fuminori Tokunaga, Seigo Terawaki, Daisuke Oikawa, Kouhei Shimizu（Dept. of Pathobiochem., Grad. Sch. of Med., Osaka CityUniv.）

3AS-02-Discussion

【11:03】

3AS-02-Conclusion

【11:13】

Makoto Kinoshita（Nagoya University）

3AS-03

9:00-11:15【E】

Room 03 (Pacifico Yokohama Conference Center, 3F, 302)

Novel approaches combining 3-dimensional biology and cutting-edge technologies to analyze tumor tissues toward theconquest of cancer
Organizers：Noriko Gotoh（Kanazawa University）
Koji Okamoto（National Cancer Center Research Institute）

3AS-03-1

【9:00】

Multicellular cancer organoid recapitulating cancer ecosystem using patient-derived pancreatic cancer cells
Keisuke Sekine（National Cancer Center Research Institute）

3AS-03-2

【9:22】The membrane-linked adaptor FRS2beta fashions a cytokine-rich inflammatory microenvironment that promotes breast
cancer carcinogenesis*
Noriko Gotoh（Div. Can. Cell BIol., Can. Res. Inst., Kanazawa Univ.）

3AS-03-3

【9:44】Innovative 3D imaging technique for next-generation cancer researchTakeshi Imamura（Dept. of Mol. Med. for Pathogenesis. Ehime Univ. Grad. Sch. of Med. ）3AS-03-4

【10:06】

Preclinical patient-derived models revealed potential therapeutic targets for renal cell carcinoma

Satoshi Inoue1,2（1Dept. Aging Sci. & Med., Tokyo Metropolitan Inst. of Gerontology, 2RCGM, Saitama Med. Univ.）

3AS-03-5

【10:28】

TEM8 marks neovasculogenic tumor initiating cells in triple negative breast cancer
Suling Liu（Fudan University）

3AS-03-6

【10:50】Understanding of cancer heterogeneity and chemoresistance via integration of single-cell analyses and spatialtranscriptomics
Koji Okamoto（Div. Cancer Differentiation, Natl. Cancer Ctr. Res. Inst.）

3AS-03-Discussion
3AS-04

Room 04 (Pacifico Yokohama Conference Center, 3F, 303)

【11:12】
9:00-11:15【E】

Mechanisms of intracellular clearance and pathogenesis caused by its disruption
Organizers：Hideki Nishitoh（University of Miyazaki）
Akira Kobayashi（Doshisha University）

3AS-04-Introduction
Hideki Nishitoh（University of Miyazaki）

3AS-04-1

【9:00】【9:01】

Clearance of aberrant nascent proteins by ribosome-associated quality control(RQC) is critical for neuron morphogenesis andsurvival

Tsuyoshi Udagawa1, Moeka Seki1, Taku Okuyama1, Shungo Adachi2, Tohru Natsume2, Takuya Noguchi1, Atsushi Matsuzawa1,Toshifumi Inada1,3（1Grad. Sch. of Pharm. Sci., Tohoku Univ., 2Molecular Profiling Research Center for Drug Discovery, AIST, 3Inst. ofMed. Sci., Univ. of Tokyo）

3AS-04-2

【9:23】

Molecular mechanism of co-translational degradation on the ER membrane

Hisae Kadowaki, Hideki Nishitoh（Lab. of Biochem. Mol. Biol. Dept. of Med. Sci., Univ. of Miyazaki）

14

第 44 回日本分子生物学会年会

第 3 日目

12 月 3 日（金）3AS-04-3

【9:45】

Wipi3 is essential for Golgi membrane-associated degradation (GOMED) pathway and its loss causes neurodegeneration

Satoko Arakawa, Hirofumi Yamaguchi, Shigeomi Shimizu（Pathol. Cell Biol., Med. Res. Inst., Tokyo Med. Dent. Univ. (TMDU)）

3AS-04-4

【10:07】

Clearance of misfolded proteins via extracellular vesicle secretion

2 1
Toshihide Takeuchi1, Yoshitaka Nagai（LSRI, Kindai Univ., 2Faculty of Med, Kindai Univ.）

3AS-04-5

【10:29】NRF1 and NRF3 complementarily maintain basal proteasome activity in cancer cells through CPEB3-Mediated translational
repression
Tsuyoshi Waku, Akira Kobayashi（Dep. of Med. Life Sys., Fac. of Life and Med. Sci., Doshisha Univ.）

3AS-04-6

【10:51】

Manipulation of the Ubiquitin Proteasome System by human papilloma virus oncoprotein
Takuya Tomita（Prot. Metab. Project, TMiMS）

3AS-04-ConclusionAkira Kobayashi（Doshisha University）【11:13】

3AS-05

Room 05 (Pacifico Yokohama Conference Center, 3F, 304)
9:00-11:15【E】
Co-hosted by: Grant-in-Aid for Scientific Research on Innovative Areas "Periodicity and its Modulation in Plants"
One small step, one giant leap: impacts of molecules and fluctuations on plant development
Organizers：Minako Ueda（Tohoku University）
Misato Ohtani（The University of Tokyo）

3AS-05-Introduction
Minako Ueda（Tohoku University）

3AS-05-1

【9:00】【9:05】

Live-cell imaging of the polarization dynamics of plant zygote

Minako Ueda1,2, Yusuke Kimata1, Hikari Matsumoto1, Takumi Higaki3, Taiho Komatsu1, Sayuri Tanaka4, Daisuke Kurihara5,6,Tetsuya Higashiyama4,5,7（1Dept. of Eco. Dev. Adapt. Life Sci., Grad. Sch. of Life Sci., Tohoku Univ., 2Suntory, SunRiSE, 3IROAST,
4Kumamoto Univ., Div. of Biol. Sci., Grad. Sch. of Sci., Nagoya Univ., 5ITbM, Nagoya Univ., 6JST, PRESTO, 7Dept. of Biol. Sci., Grad. Sch.
of Sci., Univ. of Tokyo）

3AS-05-2

【9:25】

Endoplasmic reticulum dynamics and plant development

Haruko Ueda, Ikuko Hara-Nishimura（Dept. of Biol., Fac. of Sci. & Eng., Konan Univ.）

3AS-05-3

【9:50】Morphological evolution in plant reproduction - taking plant sperms and structural color in flowers as examples Shizuka Koshimizu（Sch. Agri., Meiji Univ.）

3AS-05-Break【10:15】

3AS-05-4

【10:25】

Seasonal cues control the daily expression patterns of FT to optimize flowering time in nature

2 1
Akane Kubota1, Yusuke Ozaki1, Yoshinori Kondo1, Motomu Endo1, Takato Imaizumi（Dev. of Biosci., NAIST, 2Dept. of Biology, Univ.
of Washington）

3AS-05-5

【10:50】How to transcribe and modify which species of snRNA: metabolic regulation of small nuclear RNA is a key to environmentallyadaptable development of plants
Misato Ohtani1,2,3（1Dept. of Integ. Biosci., Grad. Sch. of Front. Sci., Univ. of Tokyo, 2Div. Biol. Sci., NAIST, 3CSRS, RIKEN）

3AS-05-ConclusionMisato Ohtani（The University of Tokyo）

The 44th Annual Meeting of the Molecular Biology Society of Japan【11:10】15

第 3 日目

3AS-1712 月 3 日（金）9:00-11:15【E】

Room 17 (Pacifico Yokohama Conference Center, 5F, 503)
Co-hosted by: Transformative Research Areas (B) Mammalian hibernation biology~ survival strategies via hypometabolism and hypothermia
Regulation of hypometabolism and hypothermia in and around hibernation
Organizers：Genshiro Sunagawa（RIKEN）
Yoshifumi Yamaguchi（Hokkaido University）

3AS-17-Introduction

【9:00】

Genshiro Sunagawa（RIKEN）

3AS-17-1

【9:03】Can torpor delay disease progression?

Genshiro A. Sunagawa（RIKEN BDR）

3AS-17-2

【9:23】

Cold adaptation and adipose tissue remodeling

Yuko Okamatsu-Ogura（Lab. of Biochem., Fac. of Vet. Med., Hokkaido Univ.）

3AS-17-3

【9:43】

Biological Clock in Cold World

3 1
Naohiro Kon1, Takahiro Iwamoto2, Yoshitaka Fukada（ITbM, Nagoya University, 2Facul. of Med., Fukuoka Univ., 3Dept. of Med.,Univ. of Tokyo）

3AS-17-4

【10:03】

Reduced glucose metabolism in the longest-lived rodent, the naked mole-rat

Kaori Oka1, Kyoko Miura1,2（1POIE, Kumamoto Univ., 2Faculty of Life Sci., Kumamoto Univ.）

3AS-17-5

【10:23】

An adenosine model of obligate hibernation

2 1
Kelly Drew1, Bernard Laughlin1, Zachary Carlson1, Carla Frare1, Sarah Rice1, Julie Reisz2, Angelo D'Alessandro（
University of Alaska
2
Fairbanks, University of Colorado Denver – Anschutz Medical Campus）

3AS-17-Conclusion

【11:13】

Yoshifumi Yamaguchi（Hokkaido University）

3PS-02

15:45-18:00【E】

Room 02 (Pacifico Yokohama Conference Center, 3F, 301)

Cell-cell communications generating “autonomy" in multicellular life systems
Organizers：Tohru Ishitani（Osaka University）
Tatsushi Igaki（Kyoto University）

3PS-02-Introduction

【15:45】

Tatsushi Igaki（Kyoto University）

3PS-02-1

【15:47】

Dissecting the core pathway of cell competition

Tatsushi Igaki（Grad. Sch. of Biostudies, Kyoto Univ.）

3PS-02-2

【16:06】

Stem cell competition: unraveling the riots that shape multicellular dynamics
Shakiba Nika（School of Biomedical Engineering, UBC）

3PS-02-3

【16:32】

Local tension imbalance drives global organ patterning and fate specification

Rashmi Priya, Srinivas Allanki, Alessandra Gentile, Shivani Mansingh, Hans-Martin Maischein, Didier Stainier（The Francis CrickInstitute）

3PS-02-4

【16:58】Mechano-chemical feedbacks in multicellular epithelial tissues for pattern formation and morphogenesis

Tsuyoshi Hirashima1,2, Michiyuki Matsuda2,3（1The Hakubi Center, Kyoto Univ, 2Grad Sch Biostudies, Kyoto Univ, 3Grad Sch Med,Kyoto Univ）

3PS-02-5

【17:19】Cell competition contributes to the autonomous error correction of morphogen gradient.
Tohru Ishitani（RIMD, Osaka Univ.）

16

第 44 回日本分子生物学会年会

第 3 日目

12 月 3 日（金）3PS-02-6

【17:38】Programming autonomous multicellular patterning with synthetic cell-cell signaling
Satoshi Toda（NanoLSI, Kanazawa Univ.）

3PS-02-Conclusion

【17:59】Tohru Ishitani（Osaka University）

3PS-16

Room 16 (Pacifico Yokohama Conference Center, 5F, 502)
15:45-18:00【E】
Supported by: Moonshot Research & Development Program "Understanding and Control of Virus-Human Interaction
Networks"
Digital transformation for fighting against emerging infectious diseases
Organizers：Teppei Shimamura（Nagoya University）
Shingo Iwami（Nagoya University）

3PS-16-Introduction

【15:45】Teppei Shimamura（Nagoya University）

3PS-16-1

【15:46】

Deep learning to decipher cell dynamics and cell-cell interactions

Teppei Shimamura（Div. of Syst. Biol., Nagoya Univ. Grad. Sch. of Med.）

3PS-16-2

【16:08】High throughput analysis of cell morphology by ghost cytometry
Sadao Ota1,2（1RCAST, Univ. of Tokyo, 2Thinkcyte Inc.）

3PS-16-3

【16:30】Respiratory virus infection model: is an equation worth a thousand pictures?

Christian Quirouette1, Nada P. Younis1, Micaela B. Reddy3, Catherine Beauchemin1,2（1Dept. Physics, Ryerson Univ., 2iTHEMS, RIKEN,
3Array Biopharma Inc.）

3PS-16-4

【16:52】

The genetic determinants of SARS-CoV-2 associated diseases

Vanessa Sancho Shimizu1,2（1Department of Paediatric Infectious Diseases and Virology, Imperial College London, 2Centre for
Paediatrics and Child Health, Faculty of Medicine, Imperial College London）

3PS-16-5

【17:14】On the use of mathematical techniques in response to COVID-19 pandemic
Hiroshi Nishiura（Kyoto University）

3PS-16-6

【17:36】

Rethinking antiviral effects for COVID-19 in clinical studies: early initiation is key to successful treatment
Shingo Iwami（iBLab, Div. of Biol. Sci., Grad. Sch. of Sci., Nagoya Univ.）

3PS-16-Conclusion
Shingo Iwami（Nagoya University）

3PS-17

Room 17 (Pacifico Yokohama Conference Center, 5F, 503)

【17:58】15:45-18:00【E】

Synthetic Embryology - Bottom-up approaches to study human & animal development
Organizers：Mitinori Saitou（Kyoto University）
Cantas Alev（Kyoto University）

3PS-17-Introduction
Mitinori Saitou（Kyoto University）

3PS-17-1

【15:45】【15:47】

Blastoids model blastocyst development and implantation.
Nicolas Rivron（IMBA）

3PS-17-2【16:13】

In vitro 3D gastruloid models of mouse and human development
Naomi Moris（Francis Crick Institute）

3PS-17-3

【16:39】Reconstituting human somitogenesis in vitro

Yoshihiro Yamanaka1, Kumiko Yoshioka-Kobayashi1, Sirajam Munira1, Sofiane Hamidi1, Shunsuke Kihara2, Yuzuru Kurokawa1,1 1
Taro Tsujimura1, Takuya Yamamoto1,2, Cantas Alev（Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University,
2
Center for iPS Cell Research and Application (CiRA), Kyoto University）
The 44th Annual Meeting of the Molecular Biology Society of Japan17

第 3 日目

3PS-17-4

12 月 3 日（金）【17:05】Synthetic pancreas organogenesis: from self-organization to understanding diabetes
Anne Grapin-Botton（Max Planck Institute of Molecular Cell Biology and Genetics）

3PS-17-5

【17:31】

A self-elongating neural tube organoid

Matthias Lutolf1,2（1Laboratory of Stem Cell Bioengineering, Institute of Bioengineering, EPFL, 2Roche Institute for Translational
Bioengineering (ITB), Roche Innovation Center Basel）

3PS-17-Conclusion
Mitinori Saitou, Cantas Alev（Kyoto University）

18【17:57】

第 44 回日本分子生物学会年会