一般社団法人日本生物物理学会 第 12 回 Biophysics and Physicobiology 論文賞受賞講演会
The 12th Award Seminar for outstanding Biophysics and Physicobiology paper
オーガナイザー：日本生物物理学会 Biophysics and Physicobiology 論文賞選考委員会
Organizers: Award committee for outstanding Biophysics and Physicobiology paper
日時：11 月 14 日（火）12:50 〜 13:50 ／ Nov. 14 Tue.

場

所：1 号館 3 階 L 会場／ Bldg1 Room L形

式：講演会／ Lecture

第 12 回 Biophysics and Physicobiology 論文賞受賞者
角田聡

Satoshi Tsunoda
名古屋工業大学

大学院生命応用化学専攻，オプトバイオテクノロジー研究センター

Department of Life Science and Applied Chemistry, Nagoya Institute of Technology
クリプト藻由来チャネルロドプシンの発見から創薬ベンチャー創出へ
GtCCR4, a channelrhodopsin with high light sensitivity
Genetic delivery of photoreceptor genes to cells and tissues originally light insensitive turns intolight-sensitive. This technique, optogenetics, has been applied in the manipulation of biological
function with unprecedented spatio-temporal precision. Channelrhodopsins (ChRs) found inchlorophyte and cryptophyte alga are directly light-gated ion channels and have been widely
applied to optogenetics tools for manipulating neuronal excitability. Furthermore, the optogenetics
approach has great potential for the restoration of visual function from an inherited disease, retinitis
pigmentosa, in which the patient loses light response of the retina.
In 2017, we identified phylogenetically distinct cation-conducting ChR (GtCCR4) from thecryptophyte algae Guillardia theta and investigated its molecular property by spectroscopy andelectrophysiology (1).
One of the striking features of GtCCR4 is its high photo-sensitivity, ~25 folds higher than a widely
known ChR2, without losing fast time response. Thus, GtCCR4 is able to trigger action potentials
in high temporal resolution, similar to ChR2, but requires lower light power when expressed inneurons (2, 3). Inspired by such marked properties of GtCCR4, we launched a start-up company
aiming for developing an effective gene therapy for curing retinitis pigmentosa.
(1) Yamauchi et al. “Molecular properties of a DTD channelrhodopsin from Guillardia theta”
Biophys. Physicobiol. 14, 57–66, 2017(2) Hososhima et al. “A light-gated cation channel with high reactivity to weak light” Sci. Rep.
13(1): 7625. 2023
(3) Hagio et al. “Optogenetic manipulation of neuronal and cardiomyocyte functions in zebrafish
using microbial rhodopsins and adenylyl cyclases” Elife 12:e83975. doi: 10.7554/eLife.83975. 2023
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一般社団法人日本生物物理学会 第 12 回 Biophysics and Physicobiology 論文賞受賞講演会
The 12th Award Seminar for outstanding Biophysics and Physicobiology paper
オーガナイザー：日本生物物理学会 Biophysics and Physicobiology 論文賞選考委員会
Organizers: Award committee for outstanding Biophysics and Physicobiology paper
日時：11 月 14 日（火）12:50 〜 13:50 ／ Nov. 14 Tue.

場

所：1 号館 3 階 L 会場／ Bldg1 Room L形

式：講演会／ Lecture

第 12 回 Biophysics and Physicobiology 論文賞受賞者
高田彰二
Shoji Takada
京都大学大学院理学研究科
Graduate School of Science, Kyoto University
郷モデルの過去と現在
Go models: Past and the current status
Since the first paper by Nobuhiro Go, the so-called Go models have been broadly applied tocomputational studies on proteins and others. I start the talk with reviewing history of Go models,followed by some latest studies that are, to some extent, related to Go models.

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