11 (Sat)プログラム

November
8:30
Door Open

Program

8:50 - 9:00

〈A-Building (AB01)〉

Opening Remarks
Isao KURAOKA

9:00 - 10:30〈A-Building (AB01)〉

Aldehyde storm: new perspectives on biological implications
Chairs: Jun NAKAMURA (Osaka Metropolitan University)

Masanobu KAWANISHI (Osaka Metropolitan University)

S1-1

9:00

1

Osaka Metropolitan University, Graduate School of Veterinary Science,
Osaka Metropolitan University, Graduate School of Science,
3
Kyoto University, Graduate School of Engineering, 4Kyoto University, Graduate School of Biostudies
2

S1-2

Aldehyde-induced premature senescence and DNA damage repair
Yuko IBUKI, Takashi SUZUKI, Yukako KOMAKI, Momoka AMANO

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka

S1-3

9:40

1

Biosignal Research Center, Kobe University, 2Graduate School of Science, Kobe University,
Faculty of Science, Kobe University, 4Graduate School of Engineering, Kyoto University,
5
Graduate School of Medicine, Kobe University

3

S1-4

10:00

DNA damage and mutations caused by aldehydes
Tomonari MATSUDA

ワークショップ

Graduate School of Engineering, Kyoto University

研究会 定例会

Impact of fatty aldehyde dehydrogenase on maintenance of genome stability
Wataru SAKAI1, 2, 3, Tomoya HOTANI1, 2, Yukie OHTSUKI1, 2, Motonari GOTO1, 2,
Maiko SASANO1, 3, Shun MATSUDA4, Tomonari MATSUDA4, Taketoshi KAJIMOTO5,
Taro OKADA5, Masayuki YOKOI1, 2, 3, Kaoru SUGASAWA1, 2, 3

ポスター

9:20

シンポジウムJapanese sensitive to alcohol beverages may be more susceptible to glycidol
toxicity
Jun NAKAMURA1, Yuya FUJITA2, Yuki TAKAMI1, Yuka HIRAKAWA2,
Tomonari MATSUDA3, Minoru TAKATA4, Toshiya OKADA1, Takeshi IZAWA1,
Masanobu KAWANISHI2

特別講演

Symposium 1

受賞講演

President, JEMS 52nd Annual Meeting
Fukuoka University

人名索引

33

プログラム10:40 - 12:10
Symposium 2〈A-Building (AB01)〉

Practical evaluation of biological effects related to mutagenicity
and carcinogenicity
Chairs: Tatsushi TOYOOKA (National Institute of Occupational Safety and Health, Japan)

Katsuyoshi HORIBATA (National Institute of Health Sciences)

Program

S2-1

10:40

Biological Effects of Long-term Continuous Low-dose Irradiation

Kazumi YAMAUCHI

Department of Radiobiology, Institute for Environmental Sciences

S2-2

11:00

Practical Evaluation of Biological Effects of Particulate Matter Using Animal
Experiments
Shotaro YAMANO

受賞講演

Japan Bioassay Research Center

S2-3

11:20

Practical Evaluation of Skin Absorption and DNA Damage Potential of Industrial
Chemicals
Tatsushi TOYOOKA
National Institute of Occupational Safety and Health, Japan

S2-4

11:40

特別講演

Practical methods and applicability for genotoxicity assessment

Katsuyoshi HORIBATA

Division of Genetics and Mutagenesis, National Institute of Health Sciences

シンポジウム

13:00 - 13:50〈A-Building (AB01)〉

General Meeting & Awards Ceremony

13:50 - 15:00〈A-Building (AB01)〉

ポスター

Award Lecture
Chair: Masami YAMADA (National Defense Academy of Japan)
JEMS Award 2023

研究会 定例会

AW

13:50

Various approaches to assess genotoxic potential of drug candidates

Masayuki MISHIMA

Translational Research Division, Chugai Pharmaceutical
JEMS Service Award 2023

SA

14:10

ワークショップ

Contribution to Environmental Mutagen Research Based on Development of an
Analytical Method to Detect Oxidative DNA Damage
Kazuaki KAWAI
Department of Environmental Oncology, University of Occupational and Environmental Health

JEMS Encouragement Award 2023

EA-1

14:30

Development of a micronucleus test using rat glandular stomach and colon

Emiko OKADA
人名索引

Yakult Central Institute, Yakult Honsha Co., Ltd.

34

EA-2

14:45

Development of an error-corrected sequencing-based mutation detection method
and its utilization for chemical mutagenicity evaluation
Shoji MATSUMURA
R&D, Safety Science Research, Kao Corporation

Symposium 3〈A-Building (AB01)〉

Genotoxicity Assessment of PAHs and Related Compounds inthe Environment --- East Asia Issues

Program

15:10 - 16:40

プログラム

JEMS Encouragement Award 2023

Chairs: Paul A. WHITE (Health Canada)

15:10

Yasunobu AOKI

S3-1

15:16

The Benchmark Dose (BMD) Approach for Analysis and Interpretation of
Polycyclic Aromatic Hydrocarbon (PAH) and PAH Mixture Mutagenicity Doseresponse Data
Paul A. WHITE1, Hannah L. BATTAION1, Alexandra S. LONG2

National Institute for Environmental Studies

1

Environmental Health Science & Research Bureau, Health Canada, Ottawa, Canada,
Existing Substances Risk Assessment Bureau, Health Canada, Ottawa, Canada

2

S3-2

15:46

Institute of Biomedical Sciences, Nagasaki University

S3-3

16:04

Assessing the cellular oxidative stress induction by exposure to photochemical
aging diesel exhaust particles using the air-liquid interface cell exposure method
Yuji FUJITANI, Akiko FURUYAMA, Go SUZUKI

シンポジウムAssessment of environmental behaviors and oxidative stress of polycyclic aromatichydrocarbon quinones in atmospheric particulate matter
Akira TORIBA, Yumi ABIKO

特別講演

Introduction

受賞講演

Yasunobu AOKI (National Institute for Environmental Studies)

National Institute for Environmental Studies

16:22

PIG-A gene mutation as a genotoxicity biomarker in occupational exposure of
PAHs and related compounds
Yiyi CAO, Jing XI, Yang LUAN
School of Public Health, Shanghai Jiao Tong University School of Medicine〈Hidamari（1F Central Library）〉

Poster Session Core time for odd numbers研究会 定例会

16:50 - 17:50

ポスター

S3-4

ワークショップ
人名索引35

プログラムNovember

12 (Sun)

8:30
Door Open

Program

9:00 - 10:30
Symposium 4〈A-Building (AB01)〉

Health Effects of Titanium Dioxide and Trends in Overseas
Regulations

受賞講演

Chairs: Saori FUJISHIMA (Chemicals Evaluation and Research Institute, Japan)

Kiyohiro HASHIMOTO (Takeda Pharmaceutical Co. Ltd.)

S4-1

9:00

Regulations for Titanium Dioxide
Tae HAYASHI, Aiko TANABE, Asako FUKUSHIMA
Chemicals Assessment and Research Center

特別講演

S4-2

9:16

Titanium dioxide as a food additive
Atsuko TADA
National Institute of Health Sciences

S4-3

9:32

Genotoxicity of Titanium Dioxide as a Food Additive
Kei-ichi SUGIYAMA

シンポジウムDivision of Genetics and Mutagenesis, National Institute of Health Sciences

S4-4

9:48

Potential risks in the cosmetic industry
Naohiro IKEDA

Safety Intelligence & Research, Product Quality Management, Kao Corporation

S4-5

10:04

The potential impact of titanium dioxide in the pharmaceutical industry

Naoki KOYAMA
ポスター

DHBL, PPD function, BA unit, Global Drug Safety, Eisai Co., Ltd.

10:40 - 12:10
研究会 定例会

Symposium 5〈A-Building (AB01)〉

Living Organisms and Mutation
Chairs: Mizuki OHNO (Kyushu University)

Kyoko HIDAKA (The University of Kitakyushu)

ワークショップ

Introduction

10:40

S5-1

10:50

Kyoko HIDAKAThe University of Kitakyushu

Study for de novo germline mutation using DNA repair-deficient mice

Mizuki OHNO

Department of Medical Biophysics and Radiation Biology, Faculty of Medical Sciences, Kyushu
University

S5-2

11:10

Mutants induced by transposable elements in the Japanese morning glory
Eiji NITASAKA
Department of Biological Science, Faculty of Science, Kyushu University

人名索引

36

11:30

Molecular evolution of Protobothrops genus snakes; perspective with environment

Takahito CHIJIWA1, Naoki IKEDA1, Kento INAMARU1, Kazuaki YAMAGUCHI1,
Hiroki SHIBATA2, Naoko ODA-UEDA3, Shin-ichi YOKOTA4, Koki TERADA5
1

Faculty of Biology and Life Science, Sojo University ,Medical Institute of Bioregulation, Kyushu University,
3
Faculty of Pharmaceutical Sciences, Sojo University,
4
The Institute of Medical Scinece, The University of Tokyo,
5
Okinawa Prefectural Institute of Health and Environment
2

11:50

Human cancer and mutation

Shinya ODA

Cancer Genetics Laboratory, Clinical Research Institute, NHO Kyushu Cancer Center〈Hidamari（1F Central Library）〉

Poster Session Core time for even numbers〈A-Building (AB01)〉

Special Lecture Starting point of human DNA Repair
Chair: Arato TAKEDACHI (Fukuoka University)

14:40

SL-1

14:45

Isao KURAOKA

Fukuoka University

Damage and repair of gene in human genetic diseases

Kiyoji TANAKA

Graduate School of Frontier Biosciences, Osaka University〈A-Building (AB01)〉

The Best Presentation Awards Ceremony & Closing Remarks

ポスター

15:40 - 16:00

シンポジウムIntroduction

特別講演

14:40 - 15:40

受賞講演

13:30 - 14:30

Program

S5-4

プログラム

S5-3

研究会 定例会
ワークショップ
人名索引37

プログラムPoster Session
Poster Discussion :【oddnumber】2023 November 11 (Sat) 16:50 - 17:50
【even number】2023 November 12 (Sun)13:30 - 14:30

Program

P-1

Structural analysis and repair mechanisms of DNA damage induced by irradiation
Toshiaki NAKANO, Ken AKAMATSU, Naoya SHIKAZONONational Institutes for Quantum Science and Technology (QST)

P-2
受賞講演

Screening of driver adduct of halogenated hydrocarbons, a causative agent of occupational
cholangiocarcinoma
Shuhei SHIRATORI1, Masami KOMIYA1, Min GI2, Shugo SUZUKI2, Hideki WANIBUCHI2,
Jiri ZAVADIL3, Kohei WATANABE1, Yukari TOTSUKA1
1

Nihon University School of Pharmacy, 2Osaka Metropolitan University Graduate School of Medicine,International Agency for Research on Cancer (IARC)

3

P-3
特別講演

Exploration of Driver Adducts and Elucidation of Mutagenesis Mechanisms in Alcohol-related
Carcinogenesis
Mina MOTOHASHI1, Yuuki BETSUYAKU2, Takeji TAKAMURA2, Masami KOMIYA1, Akira SASSA3,
Yukari TOTSUKA1
1

Nihon University, School of Pharmacy, Laboratory of Environmental Toxicology and Carcinogenesis,
Kanagawa Institute of Technology, 3Graduate School of Science, Chiba University2

P-4
シンポジウムScreening of genotoxic compounds that induce DNA double-strand breaks from naturalcompound library
Katsuhiro HANADA1, 2, Yoshihiro NISHIDA3
1

Department of Advanced Medical Sciences, Faculty of Medicine, Oita University,
Clinical Engineering Research Center, Faculty of Medicine, Oita University,
3
Department of Obstetrics and Gynecology, Faculty of Medicine, Oita University2

P-5

De novo germline mutations induced by acrylamide in gpt delta mice and effects onspermatogenesis stage during exposure

ポスター

Kenichi MASUMURA1, Tomoko ANDO2, Yuji ISHII3, Kei-ichi SUGIYAMA2
1

Division of Risk Assessment, National Institute of Health Sciences (NIHS),
Division of Genetics and Mutagenesis, NIHS, 3Division of Pathology, NIHS

2

P-6
研究会 定例会

Detection of Genotoxic Reactions Induced by The Alkylating Agent Through Directly
Analyzing DNA Damage Responses on Chromatin Fraction
Saya SASAKI, Kei-ichi SUGIYAMA, Katsuyoshi HORIBATA
Division of Genetics and Mutagenesis, National Institute of Health Sciences

P-7

ワークショップ

Exploring the genotoxicity of the bladder carcinogen BCPN by gpt assay and sequencing ofmutant colonies
Yoshiya YAMAMURA, Yuzoh TAKEZAWA, Misaki ABE, Naofumi TAKAHASHI,
Chinatsu FUJIWARA, Shinya MIYAZAKI, Kunio WADA
The Institute of Environmental Toxicology

P-8

Oxidative DNA damage by an active metabolite of COVID-19 therapeutic drug molnupiravir
Hatasu KOBAYASHI1, Yurie MORI1, Yuichiro HIRAO1, 2, Shinya KATO3, Sharif AHMED1,
Shosuke KAWANISHI4, Mariko MURATA1, Shinji OIKAWA1
1

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine,
Mie Prefectural College of Nursing,3
Radioisotope Experimental Facility, Advanced Science Research Promotion Center, Mie University,
4
Faculty of Pharmaceutical Science, Suzuka University of Medical Science
2

人名索引

38

In vivo mutagenicity analysis in rat liver samples by using ecNGS method
Kazuki IZAWA1, Masataka TSUDA1, Takayoshi SUZUKI1, Masamitsu HONMA1, 2,
Kei-ichi SUGIYAMA1
1

Division of Genetics and Mutagenesis, National Institute of Health Sciences,
Division of General Affairs, National Institute of Health Sciences

2

P-10

In vitro genotoxicity evaluation of advanced nanomaterials

1

Laboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University,
Division of Risk Assessment, Center for Biological Safety and Research, National Institute of Health Sciences2

Japan Tobacco Inc., Scientific Product Assessment Center

P-12

The analysis of mutation signature for gamma-irradiation using the supF -NGS assay

受賞講演

Mode of Action Assessment for β-Damascone-Induced Micronucleus Formation in Mammalian
Cells Using Antioxidant N-Acetyl-L-Cysteine
Satoru MUNAKATA, Tomohiro TAKAHASHI, Taku WATANABE, Mayumi ONO,
Tsuneo HASHIZUME

Program

Rikako ISHIGAMORI1, Runa SAWADA1, Manami MAEJIMA1, Masami KOMIYA1, Akiko OHNO2,
Yukari TOTSUKA1

P-11

プログラム

P-9

Ren IWATA1, Hidehiko KAWAI1, 2, Hiroyuki KAMIYA1, 2
1

School of Pharmaceutical Sciences, Hiroshima University,
Graduate School of Biomedical and Health Science, Hiroshima University

2

Development of automatic observation system for miniaturized Ames test (Ames MPF assay)

Asami MARUCHI, Ryoko MATSUYAMA, Sachiko KITAMOTO, Hiroyuki ASANO
Sumitomo Chemical Co., Ltd.

P-14

Action-at-a-distance mutations caused by uracil mismatches

1

School of Pharmaceutical Sciences, Hiroshima University,
Graduate School of Biomedical and Health Sciences, Hiroshima University,
3
Bioprocess Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)
2

Construction of a cofactor-supplemented in vitro micronucleus test system using phase II
drug-metabolizing enzymes
Manabu YASUI1, Akiko UKAI1, Shinya SHIBUTANI2, Honma MASAMITSU3, Kei-Ichi SUGIYAMA1
Div. Genetics and Mutagenesis, National Institute of Health Sciences,
Dept. Pharma. Sci., Stony Brook Univ. Med. Sch., State Univ. of New York,Div. General affairs, National Institute of Health Sciences

2
3

P-16

1

Department of Applied Chemistry, National Defense Academy,
Division of Genetics and Mutagenesis, National Institute of Health Sciences

2

P-17

Evaluation of genotoxicity and carcinogenicity of DEHP by in vitro toxicity testing
Maki NAKAMURA, Yui YOSHIMOTO, Takayuki FUKUDA, Shuichi HAMADA

研究会 定例会

Identification of bacteria and workflow of detection of mutations using the nanopore sequencer
MinION
Kohei HIGASHI1, Takayoshi SUZUKI2, Masami YAMADA1

ポスター

1

シンポジウムHiroki TAKATA1, Tetsuya SUZUKI1, 2, Yasuo KOMATSU3, Hiroyuki KAMIYA1, 2

P-15

特別講演

P-13

BoZo Research Center Inc.

BMS collaborative study‚ Comparison of the sensitivity to weak mutagens ; in Salmonella
typhimurium TA97‚TA97a vs TA1537 and Escherichia coli WP2uvrA ⁄pKM101 vs WP2uvrA
Yasuyoshi MIURA1, Kazushi MATSUMURA1, Toshiro FUKUSHIMA1, Kei-ichi SUGIYAMA2,
Katsuyoshi HORIBATA2, Masayuki KATO3, Takuya KANNO4, Atsushi HAKURA5
1

R&D Group, Japan Tobacco Inc.,
Division of Genetics and Mutagenesis, National Institute of Health Sciences,3
Formerly affiliated BoZo Research Center Inc., 4CMIC Bioresearch Center, CMIC Pharma Science Co., Ltd.,
5
Global Drug Safety, Eisai, Co., Ltd.

ワークショップ

P-18

2

Variations of urinary 8-hydroxyguanosine, a biomarker of RNA oxidative damage

Yun-Shan LI, Yuya KAWASAKI, Koichi FUJISAWA, Kazuaki KAWAI

Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational andEnvironmental Health

39

人名索引

P-19

プログラム

P-20

Identification of epigenetic effects of a potent tumor promoter TPA using the epi-TK assay

Haruto YAMADA1, Mizuki ODAGIRI1, Manabu YASUI2, Masamitsu HONMA2, Kei-Ichi SUGIYAMA2,
Kiyoe URA1, Akira SASSA1
1

Graduate School of Science and engineering, Chiba University,
Division of Genetics and Mutagenesis, National Institute of Health Sciences

2

P-21

Program

Formation of DNA double strand breaks after coexposure to UVA1 and UVB―relationshipwith cytosolic DNA―
Mai NARIMICHI, Yukako KOMAKI, Yuko IBUKI
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka

P-22

Mechanism of DNA damage induced by myricetin via reactive oxygen species generation

Yuichiro HIRAO1, 2, Hatasu KOBAYASHI1, Yurie MORI1, Shinya KATO3, Shosuke KAWANISHI4,
Mariko MURATA1, Shinji OIKAWA1

1

Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine,
Department of Home Care Nursing, Mie Prefectural College of Nursing,3
Radioisotope Experimental Facility, Advanced Science Research Promotion Center, Mie University,
4
Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science

受賞講演

2

P-23

The role of intracellular enzymatic activity of ribonuclease H2 in genome stability

Ayano WATANABE1, Yuiko MAYUZUMI1, Kazuma NAKATANI2, Kiyoe URA1, Eisuke ITAKURA1,
Akira SASSA1
特別講演

1

Graduate School of Science and Engineering ,Chiba University,
Graduate School of Medical and Pharmaceutical Sciences , Chiba University

2

P-24

The effect of blackcurrant extract on photoaging

Mei YAMAUCHI, Nanami MIURA, Ryousuke KOYAMA, Ayumi YAMAMOTO
National Institute of Technology, Hachinohe College
シンポジウム

P-25

Augmentation of genotoxicity induced by carbon-based nanomaterials with UV-irradiation

Natsumi MIZOBATA1, Ayano MIYATA2, Kotori MIYAI3, Masanobu KAWANISHI4

1

Department of Biological Chemistry,OsakaMetropolitan University,
Department of Biology,OsakaPrefecture University, 3Department of Biology,OsakaPrefecture University,
4
Department of Biological Chemistry,OsakaMetropolitan University
2

P-26
ポスター

Study of TK6 micronucleus test method to assess the genotoxicity of substances containing live
bacteria
Yohei FUJIISHI, Ikuyo MAKINO, Wakako OHYAMA, Kazunori NARUMI, Akinobu KURITA,
Emiko OKADA
Yakult Central Institute for Microbiological Research

P-27
研究会 定例会

Analysis of somatic mutations in rpsL -Tg⁄Msh2 deficient mice: A comparison with NGS
analysis
Noriko TAKANO1, Kyoko HIDAKA2, Yasunobu AOKI3, Takehiko NOHMI4, Yoshimichi NAKATSU1, 5,
Teruhisa TSUZUKI6, Mizuki OHNO1
1

Faculty of Medical Sciences, Kyushu University, 2Centre for Fundamental Education, University of Kitakyushu,
Health and Environmental Risk Division, National Institute for Environmental Studies,
4
Division of Genetics and Mutagenesis, National Institute of Health Sciences,5
Clinical Research Institute, National Kyushu Cancer Center, 6Kyushu University
3

ワークショップ

P-28

Current Status and Future Prospects of Toxicogenomics Biomarkers
Takayoshi SUZUKI1, Chie FURIHATA2
1

Division of Genetics and Mutagenesis, National Institute of Health Sciences,
Division of Molecular Targets & Gene Therapy Products, National Institute of Health Sciences

2

P-29

人名索引

Genome wide detection of low-frequency mutations in plant population mutagenized withgamma ray
Yoshihiro HASE, Katsuya SATOH, Satoshi KITAMURA

Takasaki Institute for Advanced Quantum Science, National Institutes for Quantum Science and Technology (QST)40

Genotoxicity evaluation and measurement of spontaneous mutation frequency of colibactinproducing E. coli using a DNA repair-deficient strain
Osamu TSUBOHIRA1, Ai UESHIMA1, Yuta HISATOMI1, Yoshimitsu ODA1, Yuta TSUNEMATSU2,
Michio SATO2, Yuichiro HIRAYAMA2, Noriyuki MIYOSHI3, Yuji IWASHITA4, Yuko YOSHIKAWA5,
Haruhiko SUGIMURA4, Yukari TOTSUKA6, Keiji WAKABAYASHI3, Kenji WATANABE2,
Masanobu KAWANISHI1

プログラム

P-30

1

Laboratory of Environmental Molecular Toxicology, Graduate School of Science, Osaka Metropolitan University,
Pharmacy Department, University of Shizuoka, 3Department of Food and Nutrition, University of Shizuoka,
4
Medical Faculty, Hamamatsu University School of Medicine,5
Veterinary Department, Nippon Veterinary And Life Science University, 6Pharmacy Department, Nihon University
2

Comparison of base damage and mutation by gamma-rays and carbon ion beam

Hiroaki TERATO1, Yuka TOKUYAMA2, Kanae MORI2, Midori ISOBE1

Program

P-31

1

Department of Radiation Research, Advanced Science Research Center, Okayama University,
Department of Instrumental Analysis, Analytical Research Center for Experimental Sciences, Saga University

2

Internal and External Exposure to Cesium-137 Caused Different Biological Reactions at Equal
Doses
Hiroo NAKAJIMA1, Mizuki OHNO2, Noriko TAKANO2, Satoru ENDO3, Hiroshi ISHIHARA4

受賞講演

P-32

1

Osaka University, 2Kyushu University, 3Hiroshima University, 4QST

P-33

CMIC Bioresearch Center, CMIC Pharma Science Co., Ltd.

P-34

Investigation of DNA polymerases that act in the mutagenesis of aristolochic acid in bacteria

Department of Applied Chemistry, National Defense Academy

Genotoxicity evaluation of heated tobacco products
Masami KOMIYA1, Kotaro HIROTA1, Taiga YAMAGUCHI1, Rikako ISHIGAMORI1, Yohei INABA2,
Yukari TOTSUKA1

シンポジウムMasami YAMADA, Miyuri FUJII, Daichi KOYABU
P-35

特別講演

Comparison of the standard Ames test and Enhanced Ames Test for nitrosamine drug
substance related impurities
Takuya KANNO, Kiseki KAWAHARA, Shunsuke NAKAGAWA, Masato HIRAI, Yukiko OZEKI,
Hiroyuki KOMATSU, Akihiro KANNO

1

Department of Environmental Toxicology, School of Pharmacy, Nihon University,
Department of Environmental Health, National Institute of Public Health2

Impact of plasma protein binding rate of chemical substance on in vitro /vivo micronucleus test
results
Rie TAKAGI, Kaori KIKUCHI, Junya HIRATA, Horobumi ASAI, Naoki YOSHIOKA, Mie AKANUMA

ポスター

P-36

Safety Research Center, KUREHA Corporation

Genotoxic studies on aristolochic acid I: an in vitro study using human-induced hepatocytes

Yushi HU, Yang LUAN

Shanghai Jiao Tong University

P-38

Safety Research Laboratories, Mitsubishi Tanabe Pharma Corporation

P-39

Effects of endogenous formaldehyde metabolic dysfunction on cells

Yuka HIRAKAWA1, Jun NAKAMURA2, Haruna NAGAYOSHI3, Minoru TAKATA4,
Masanobu KAWANISHI1

ワークショップ

Plasmid introduction itself increased the levels of DNA damage markers in cultured cells --acase observed in the process of the genotoxicity evaluation of transfected proteins-Tsuyoshi YOKOBATA, Katsuya YAMADA, Chinami ARUGA, Kenji WATANABE, Eiji YAMAMURA,
Takuya FUJITA

研究会 定例会

P-37

1

Laboratory of Environmental Molecular Toxicology, Graduate School of Science, Osaka Metropolitan University,
Graduate School of Veterinary Science, Osaka Metropolitan University,
3
Division of Hygienic Chemistry , Osaka Institute of Public Health,4
Graduate School of Biostudies, Kyoto University
2

人名索引

41

プログラム

P-40

Shape changes of cell nuclei in cultured mammalian cells: a study of cell nucleus distortion(increased roundness)
Kenji TAKESHITA, Shiunji FURUKUMA, Shigeo KURATAUBE Scientific Analysis Laboratory, Inc.

P-41

Antimutagenicity of fruits juice toward MNNG

Sakae ARIMOTO

Graduate School of Medicine, Dentistry and Pharmacetical Sciences

Program

P-42

Establishment of an in vitro detection system based on ERK phosphorylation to detect nongenotoxic carcinogens
Hodaka YAMAMOTO, Misaki TANAKA, Kenji TANAKA, Akira TAKEIRI, Masayuki MISHIMA
Safety and Bioscience Dept., Translational Research Division, Chugai Pharmaceutical Co. Ltd.,

受賞講演

P-43

Modulatory effects of SP600125 and its structural analogues on AhR activation

Naoteru DENTA, Ayane IKEDA, Kentaro SHIINA, Masashi SEKIMOTO

Laboratory of Environmental Hygiene, Department of Health and Environmental Sciences, Azabu University

P-44

State and challenge of expert review of QSAR mutagenicity prediction

Masayuki MISHIMA

Translational Research Division, Chugai Pharmaceutical
特別講演

P-45

Development of in silico mutagenicity (Ames test) prediction considering metabolism
Mika IMAMURA1, Masakazu TATESHITA2, Satoshi SUGIYAMA2, Ryoichi MURAKAMI2,
Yasushi HIKIDA2, Koji TAKAKU3
1

Safety Evaluation Center, Ecology & Quality Management Division, ESG Division, FUJIFILM Corporation,
Informatics Research Laboratory, ICT Strategy Division, FUJIFILM Corporation,
3
CRO Business Development Office, FUJIFILM Corporation
2

シンポジウム

P-46

The construction of prediction model for the unpredictable structures such as primaryaromatic amines and aromatic boronic acids in the Ames mutagenicity prediction system‘YosAI’
Naoki KOYAMA1, Atsushi HAKURA1, Masaki KURAKAMI1, Minetaka ISOMURA2,
Tomoki NISHIOKA3, Seiji HITAOKA3, Takeo SASAKI2, Yusuke NAKATANI2, Tsubasa NAKAUE2,
Nicolas K SHINADA4, Sucheendra K PALANIAPPAN4, Matsuoka YUKIKO4, Shoji ASAKURA1
1

ポスター

DHBL, PPD function, BA unit, Global Drug Safety, Eisai Co., Ltd.,DHBL, PPD function, PST Unit, Eisai Co., Ltd. , 3Emerging Modality Generation Department, Eisai Co., Ltd. ,4
SBX Corporation2

P-47

xenoBiotic: Ames mutagenicity predictor (2023), prediction performance to aromatic amines

Toshihiko SAWADA1, 2, Tomohiro HASHIMOTO1, Hiroaki WASADA1
1

Faculty of Regional Studies, Gifu University, 2xenoBiotic Inc.

研究会 定例会

P-48

Performance evaluation of QSAR software xenoBiotic using quantum chemical calculations
Kiyohiro HASHIMOTO1, Toshihiko SAWADA2
1

Drug Safety Research and Evaluation, Takeda Pharmaceutical Co. Ltd., 2xenoBiotic Inc.

P-49

Some Topics about N-Nitrosamines -Ames Testing for NDMA and NDEA-

ワークショップ

Ayako FURUHAMA1, Kei-ichi SUGIYAMA1, Masamitsu HONMA2
1

Division of Genetics and Mutagenesis, National Institute of Health Sciences (NIHS),
Division of General Affairs, National Institute of Health Sciences (NIHS)

2

P-50

Overview of OECD QSAR Assessment Framework (QAF) with a case study

Ayako FURUHAMA1, Taeko MARUYAMA-KOMODA2, Takashi YAMADA2, Kei-ichi SUGIYAMA1,
Masamitsu HONMA3
1

Division of Genetics and Mutagenesis, National Institute of Health Sciences (NIHS),
Division of Risk Assessment, National Institute of Health Sciences (NIHS),
3
Division of General Affairs, National Institute of Health Sciences (NIHS)
2

人名索引

42

Application of quantum mechanics to QSAR expert review on aromatic amines (2)Shigeharu MUTO1, Ayako FURUHAMA2, Mika YAMAMOTO3, Yasuteru OTAGIRI4,
Naoki KOYAMA5, Seiji HITAOKA5, Yusuke NAGATO6, Hirofumi OUCHI7, Masahiro OGAWA8,
Kisako SHIKANO8, Katsuya YAMADA9, Satoshi ONO9, Minami HOKI10, Fumiya ISHIZUKA11,
Soichiro HAGIO12, Chiaki TAKESHITA13, Hisayoshi OMORI14, Kiyohiro HASHIMOTO15,
Satsuki CHIKURA16, Masamitsu HONMA2, Kei-ichi SUGIYAMA2, Masayuki MISHIMA1
Chugai Pharmaceutical, 2National Institute of Health Sciences, 3Astellas Pharma, 4EA Pharma, 5Eisai,
FUJIFILM Toyama Chemical, 7Japan Tobacco, 8Kumiai Chemical Industry, 9Mitsubishi Tanabe Pharma,
10
Nihon Nohyaku, 11Nippon Shinyaku, 12Nissan Chemical, 13Ono Pharmaceutical, 14Taiho Pharmaceutical,
15
Takeda Pharmaceutical, 16Teijin Pharma

プログラム

P-51

1
6

Studies for Mutagenicity-prediction of Aromatic Boronic Acids

Minetaka ISOMURA, Takeo SASAKI, Yusuke NAKATANI, Tsubasa NAKAUE, Naoki KOYAMA,
Atsushi HAKURA, Masaki KURAKAMI, Tomoki NISHIOKA, Seiji HITAOKA

Program

P-52

Eisai Co., Ltd.

Regulatory trends and considerations in establishment of acceptable intake for nitrosamine
drug substance-related impurities (NDSRI)
Shinji TAMURA

受賞講演

P-53

ONO PHARMACEUTICAL CO., LTD.

P-54

FUJIFILM Toyama Chemical Co., Ltd.

P-55

特別講演

Establishment of the Acceptable Intakes for N-Nitrosamines Using Structure-Activity
Relationship/Read Across Approach
Yusuke NAGATO, Miki ISHINO
Nitrosamine Management Challenges in the Pharmaceutical Industry

Yosuke MINO
P-56

Towa's approach for the issue of Nitrosamines contamination in drug Products

Shohei FUKUDA, Kanako KONDO, Shoji FUKUMOTO
TOWA PHARMACEUTICAL

P-57

1

Global Drug Safety, Eisai Co., Ltd., 2Tsukuba R&D Supporting Division, Sunplanet Co., Ltd.,
Advanced Data Assurance, Eisai Co., Ltd.

3

P-58

Detection of metabolites involved in the mechanism of acetamide induced large micronuclei

1

Division of Pathology, National Institute of Health Sciences,
Division of Environmental Chemistry, National Institute of Health Sciences,
3
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology
2

1

Kyoto University Department of Environmental Engineering,
National Institute of Advanced Industrial Science and Technology,
3
Kyoto University Undergraduate Course Program of Environmental Engineering2

P-60

ワークショップ

Application of Tracing Evolution of Antibody along time course (TEA-time) to rabbits using
single cell analysis with split pool barcoding
Yuki NISHIJIMA1, Yuki KOBAYASHI3, Megumi OKA1, Yoko AKAZAWA2, Yoshihisa HAGIHARA2,
Tomonari MATSUDA1

研究会 定例会

Yuji ISHII1, Norifumi TAKIMOTO1, 3, Maiko TAHARA2, Tsuyoshi KAWAKAMI2, Meili SOMA1,
Shinji TAKASU1, Kumiko OGAWA1

P-59

ポスター

Ames test and structure-activity relationship on tricyclic heterocycles
Masaki KURAKAMI1, Atsushi HAKURA1, Rika SATO2, Akihiro KAWADE2, Takeshi YAMAGATA3,
Naoki KOYAMA1, Dai KAKIUCHI1, Shoji ASAKURA1

シンポジウムJapan Tobacco INC.

Functional diversity and mutation among SVMP isozymes

Daiki MIHARA1, Tomoko AOKI2, Isao KURAOKA1, Narumi AOKI-SHIOI2
Department of Chemistry, Graduate School of Science, Fukuoka University,
Department of Chemistry, Faculty of Science, Fukuoka University

2

43

人名索引

1

プログラムP-61

Dynamic roles of catalytic residues in base excision repar with hOGG1

Masayuki MORIKAWA1, Yoshikazu HATTORI1, 2, Mariko FUKUTA1, Fuka TSUYUGUCHI1,
Kota SHIGEMATSU1, Yusuke OCHI1, Ryuto TOMINAGA1, Ren INAMURA1, Riki NAKATSUKA1,
Takuya OKADA1, Naoya ICHIHARA1, Haruka MANO1, Masaki UNNO3, 4, Yoshiyuki TANAKA1
1

Faculty of Pharmaceutical Sciences, Tokushima Bunri University,
Institute of Advanced Medical Sciences, Tokushima University,
3
Institute of Quantum Beam Science, Graduate School of Science and Engineering, Ibaraki University,
4
Frontier Research Center for Applied Atomic Sciences, Ibaraki University
2

Program

P-62

Genetic analysis of the DNA double-strand break induction mechanism of flavonoid quercetin

Yuduki SOMEYA1, Shinta SAITO2, Sakine KOBAYASHI3, Shigeki TAKEDA1, 3, Noritaka ADACHI2,
Aya KUROSAWA1, 2, 3, 4
1

Grad. Sch. Sci. Tech., Gunma Univ., 2Grad. Sch. Nanobiosci., Yokohama City Univ., 3Sch. Sci. Tech., Gunma Univ.,
Gunma Univ. Cent. Food Sci. Wellness, Gunma Univ.

4

受賞講演

P-63

Analysis of the cell-killing mechanism of genistein

Mahiro FUJITA1, Yuduki SOMEYA1, Sakine KOBAYASHI2, Kazuya TORIUMI1, Shigeki TAKEDA1, 2,
Noritaka ADACHI3, Aya KUROSAWA1, 2, 3, 4
1

Grad. Sch. Sci. Tech., Gunma Univ., 2Sch. Sci. Tech., Gunma Univ., 3Grad. Sch. Nanobiosci., Yokohama City Univ.,
Gunma Univ. Cent. Food Sci. Wellness, Gunma Univ.

4

特別講演

P-64

Withdrawal

P-65

Visible light induces matrix metalloproteinases expression and subsequent photoaging
Yosuke HIRAGA1, Taiki SATO1, Takahiro HARADA2, Kazuomi SATO1, 2
1

Graduate School of Agriculture, Tamagawa University,
Department of Agri-Production Sciences, College of Agriculture, Tamagawa Unviersity

2

シンポジウムP-66

Roles in the action-at-a-distance mutations of DNA glycosylases involved in the repair ofoxidatively damaged bases
Yoshihiro FUJIKAWA, Tetsuya SUZUKI, Hidehiko KAWAI, Hiroyuki KAMIYA
Department of Nucleic Acids Biochemistry, Graduate School of Biomedical and Health Sciences, Hiroshima
University

P-67

Genomic instability caused by deaminated nucleotides and its defense system

ポスター

Tatsuo NUNOSHIBA1, Chie MITSUI1, Akira MURATA1, Yohei SUGIMOTO1, Natsumi NAKASHIMA1,
Kenshiro NISHIHARA1, 2, 3, Miki NISHIMURA1
1

International Christian University, 2Graduate School of Medicine, Juntendo University,
National Cancer Center Institute for Cancer Control

3P-68
研究会 定例会

Repair of topoisomerase 1–induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2)
is dependent on its magnesium binding
Naoto SHIMIZU1, Hiroshi IDE1, Masataka TSUDA2

1

Program of Mathematical and Life Sciences, Graduate School of Integrated Sciences for Life, Hiroshima University,
Division of Genetics and Mutagenesis, National Institute of Health Sciences

2

P-69

Cigarette sidestream smoke-induced cellular senescence and the effect of histone H2AX
knockdown
Yuko IBUKI, Yukako KOMAKI

ワークショップ

Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka

P-70

Mutations induced by 5-hydroxycytosine in human U2OS cells

Ann HIROTA1, Tetsuya SUZUKI1, Shigenori IWAI2, Hiroyuki KAMIYA1
1

Graduate School of Biomedical and Health Sciences, Hiroshima University,
Graduate School of Engineering Science, Osaka University

2

P-71
人名索引

Involvement of uracil DNA glycosylase on the action-at-a-distance mutations by 8-oxo-7,8dihydroguanine
Saho YOSHIDA, Tetsuya SUZUKI, Hiroyuki KAMIYA
Graduate School of Biomedical and Health Sciences, Hiroshima University

44

Analysis of action-at-a-distance mutations induced by a natural abasic site

Kiyoharu YASUI1, Tetsuya SUZUKI1, Yasuo KOMATSU2, Hiroyuki KAMIYA1
1

Graduate School of Biomedical and Health Sciences, Hiroshima University,
Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

2

P-73

プログラム

P-72

Elucidation of the mechanism of the translesion RNA synthesis of RNA-dependent RNA
polymerase of SARS-CoV-2
Masataka AKAGAWA1, Petr GRúZ2, Kaoru SUGASAWA3, Kiyoe URA1, Akira SASSA1
1

P-74

Analysis of cytotoxic effects caused by the deletion of fatty aldehyde dehydrogenase

1

Biosignal Research Center, Kobe University, 2Graduate School of Science, Kobe University,
Faculty of Science, Kobe University, 4Graduate School of Engineering, Kyoto University,
5
Graduate School of Medicine, Kobe University
3

P-75

1

Graduate School of Science and Engineering, Chiba University, 2Tokyo Laboratory, BoZo Research Center Inc.,
Graduate School of Medical and Pharmaceutical Sciences, Chiba University,
4
Biosignal Research Center, Kobe University

特別講演

Molecular mechanism of genome instability induced by accumulation of ribonucleotides in the
genomic DNA
Asuka TACHIKAWA1, Yui YOSHIMOTO2, Ken TAKAFUJI1, Yuiko MAYUZUMI1,
Kazuma NAKATANI3, Maki NAKAMURA2, Takayuki FUKUDA2, Kaoru SUGASAWA4, Kiyoe URA1,
Akira SASSA1

受賞講演

Tomoya HOTANI1, 2, Yukie OHTSUKI1, 2, Motonari GOTO1, 2, Maiko SASANO1, 3, Shun MATSUDA4,Tomonari MATSUDA4, Taketoshi KAJIMOTO5, Taro OKADA5, Masayuki YOKOI1, 2, 3,
Kaoru SUGASAWA1, 2, 3, Wataru SAKAI1, 2, 3

Program

Graduate School of Science, Chiba University,
Division of Genetics and Mutagenesis, National Institute of Health Sciences,3
Biosignal Research Center, Kobe University
2

3

Construction of new Ames tester strain deficient in the AlkB demethylase

Petr GRUZ1, Masami YAMADA2, Masamitsu HONMA3, Katsuyoshi HORIBATA1,
Kei-ichi SUGIYAMA1
1

Division of Genetics and Mutagenesis, National Institute of Health Sciences,
National Defense Academy, Department of Applied Chemistry, 3National Institute of Health Sciences

2

P-77

1

Graduate School of Science, Chiba University,
Graduate school of Medical and Pharmaceutical Science, Chiba University,
3
Division of Genetics and Mutagenesis, National Institute of Health Sciences,4
Graduate School of Medicine, Chiba University, 5Biosignal Research Center, Kobe University

ポスター

Identification of molecular pathway for excessive interferon response caused by DNA damage
Nao TERAKOSHI1, Ken TAKAFUJI1, Kazuma NAKATANI2, Manabu YASUI3, Masamitsu HONMA3,
Kei-ichi SUGIYAMA3, Ryoji FUJIKI4, Atsushi KANEDA4, Kaoru SUGASAWA5, Kiyoe URA1,
Akira SASSA1

シンポジウム

P-76

2

Cleavage of DNA oligomers at a novel guanine oxidation damage by endonuclease Ⅷ
Taishu KAWADA1, Nishiyama HARUNA1, Katsuhito KINO2, 3
1

Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University,
Department of Nano Material and Bio Engineering, Faculty of Science and Engineering, Tokushima Bunri University,
Center for Advance Science and Engineering, Tokushima Bunri University

2
3

Replication factor RFC2 directly binds to nucleotide excision repair factor XPF

Aya YOSHIDA, Akane MATSUMOTO, Isao KURAOKA

Department of Chemistry, Faculty of Science, Fukuoka University

P-80

Fluorescence detection of non-homologous end joining repair in living cells

Gakuto FUKUSHIMA, Isao KURAOKA, Arato TAKEDACHI

ワークショップ

P-79

研究会 定例会

P-78

Functional Biochemistry Laboratory, Department of Chemistry, Faculty of Science, University of Fukuoka.

Base preference of Human EndonucleaseV

Kazuma MITSUOKA, Isao KURAOKA

Department of Chemistry, Faculty of Science, Fukuoka University

45

人名索引

P-81

プログラム

P-82

Replication factor C interacts with Structure-specific endonuclease ERCC1-XPF

Akane MATSUMOTO, Arato TAKEDACHI, Isao KURAOKA
Department of Chemistry, Faculty of Science, Fukuoka University

P-83

Novel reporter plasmid for evaluating DNA mismatch repair proficiency in human cells

Tomoki SHIRAKAWA1, Arato TAKEDACHI1, Erina MATSUISHI1, Shouji MIZUSAKI1,
Tomoki NAGASAWA1, Ryosuke FUJIKANE2, 3, Masumi HIDAKA2, Shigenori IWAI4, Isao KURAOKA1
1

Department of Chemistry, Faculty of Science, Fukuoka University,
Department of Physiological Science and Molecular Biology, Fukuoka Dental College,
3
Oral Medicine Research Center, Fukuoka Dental College,
4
Graduate School of Engineering Science, Osaka University
2

Program

P-84

Functional regulation of DNA helicase RTEL1 via ubiquitination

Kosuke MATSUO1, Remi TAMEDA1, Hidefumi IWASHITA1, Yusuke SANADA2, Shinsuke ITO3,
Isao KURAOKA1, Arato TAKEDACHI1
受賞講演

1

Dpt of BioChem, Grad. Sch. of Sci, Fukuoka Univ, 2Dpt of Physchem, Faculty of Sci, Fukuoka Univ, 3RIKEN IMS

P-85

Quantitative analysis of the mismatch repair using the fluorescent reporter plasmid
Ryosuke FUJIKANE1, 2, Isao KURAOKA3, Masumi HIDAKA1, 2
1

Department of Physiological Science and Molecular Biology, Fukuoka Dental College,
Oral Medicine Research Center, Fukuoka Dental College,3
Department of Chemistry, Faculty of Science, Fukuoka University
2

特別講演

P-86

Development of visualization technique for dynamic change in resolution of homologous
recombination intermediate
Masataka TSUDA1, Naoto SHIMIZU2

1National Institute of Health Sciences, 2Hiroshima University

シンポジウム

P-87

RGG domain of DHX9 plays pivotal roles in DNA double-strand break repair

Yuina TSUCHIYA1, Hayaki IKEGAME1, Yurina ABE2, Ryotaro NISHI1, 2
1

Molecular Biology Laboratory, Graduate school of Bionics, Tokyo University of Technology,
Molecular Biology Laboratory, School of Biosciences and Biotechnology, Tokyo University of Technology

2

P-88

Establishment of a novel method for evaluating direct protein-protein binding

Manami KAWASAKI1, Mayu YAMASHITA1, Shinsuke ITO2, Yusuke SANADA3, Arato TAKEDACHI1,
Isao KURAOKA1
ポスター

1

Department of Biochemistry, Fukuoka University, 2RIKEN IMS,
Department of Physical Chemistry, Fukuoka University

3

P-89

Exploring Cardiac Aging-Associated Mutations Using DNA Repair-Deficient Mice

Kyoko HIDAKA1, Sugako OKA2, Noriko TAKANO2, Jong-Kook LEE3, Mizuki OHNO2
1

Ctr. Fundam. Ed., Univ. of Kitakyushu, 2Dept. Med. Biophys. & Radiat. Biol., Med. Sci., Kyushu Univ.,
Dep. of Cardiovasc. Regen. Med. & Drug Discov., Osaka Univ.

3

研究会 定例会

P-90

Sensitivity of human hOGG1-over expressing cells to radiation and oxidative stress
WeiZhi WANG1, LanYun YAN1, Yukihiro YOSHIKAWA1, Masashi TAKAO2, QiuMei Zhang AKIYAMA1
1

Department of Zoology, Division of Biology, Graduate School of Science, Kyoto University,
Department of Project Programs, Institute of Development, Aging and Cancer, Tohoku University2

ワークショップ

P-91

Analysis of somatic mutations and clonal dynamics of mouse hematopoietic stem cells after
whole-body X–irradiation by whole–genome sequencing
Yukiko MATSUDA1, 2, Arikuni UCHIMURA1, Yasunari SATOH1, Naohiro KATO3,
Masaaki TOSHISHIGE1, Junko KAJIMURA2, Kanya HAMASAKI1, Kengo YOSHIDA1,
Tomonori HAYASHI1, 2, Asao NODA1, Osamu TANABE1, 2
1

Department of Molecular Biosciences, Radiation Effects Research Foundation,
Biosample Research Center, Radiation Effects Research Foundation,3
Department of Statistics, Radiation Effects Research Foundation
2

人名索引

P-92

Chemo-preventive effect of Ki16425 a lysophosphatidic acid receptor inhibitor on estrogeninduced mammary tumor
Yoshinori OKAMOTO, Akira AOKI, Hideto JINNO
Faculty of Pharmacy, Meijo University

46

Validation of a questionnaire to evaluate specific phases in the menstrual cycle for cancer risk
assessment study
Rie YOSHIDA
Psychiatric Reserch Institute, Midorikai-Healthcare Group

P-94

1

Global Drug Safety, Eisai Co., Ltd., 2Food and Drug Safety Center, Hatano Research Institute,
Operations Department, Global Safety HQS, 4Biotechnical Center, Japan SLC, Inc,
5
Graduate School of Engineering, Kyoto University,
6
Center for Biological Safety and Research, National Institute of Health Sciences
3

P-95

Laboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University

P-96

受賞講演

Investigation of methylamine dichloramine-derived mechanisms contributing to colitisassociated cancer
Kohei WATANABE, Yasuyo SHIMODA, Masami SAKANO, Yukari TOTSUKA, Koichi KATO

Program

DNA polymerase κ suppresses inflammation and inflammation-induced mutagenesis anddysplasia in the colon of miceAtsushi HAKURA1, Hajime SUI2, Yuki SEKI1, Jiro SONODA3, Yusaku YOSHIDA4,
Hisayoshi TAKAGI4, Shigeo YOKOSE4, Tomonari MATSUDA5, Shoji ASAKURA1, Takehiko NOHMI6

プログラム

P-93

TP53 mutation spectrum in human cancer and germline
Mao YUKUTAKE
Fukuoka University Faculty of Science

Aberrant DNA Methylation in Arsenic-induced Bladder Carcinogenesis

Min GI1, Masaki FUJIOKA2, Shugo SUZUKI2, Tomoki YAMAMOTO2,
Arpamas VACHIRAARUNWONG1, Anna KAKEHASHI2, Hideki WANIBUCHI2

特別講演

P-97

1

Department of Environmental Risk Assessment, Osaka Metropolitan University Graduate School of Medicine,
Department of Molecular Pathology, Osaka Metropolitan University Graduate School of Medicine

2

Difference of DNA damage responses after radiation exposure between infants and adults
mice: insights from cellular responses
Guanyu ZHOU1, Megumi SASATANI2, Satoshi TASHIRO1, Kenji KAMIYA3
1

Department of Cellular Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University,
Department of Experimental Oncology, RIRBM, Hiroshima University, 3Hiroshima University

2

P-99

R&D, Safety Science Research, Kao Corporation, 2PQM, Safety Management, Kao Corporation,
Global Drug Safety, Biopharmaceutical Assessments, Pharmaceutical Profiling & Development function, DHBL,
Eisai Co., Ltd.,
4
Tsukuba Division, Sunplanet Co., Ltd., 5Toxicology & DMPK Research Department, TEIJIN PHARMA LIMITED,
6
Global Development Department, TEIJIN PHARMA LIMITED,
7
Division of Genetics and Mutagenesis, National Institute of Health Sciences,
8
Division of Risk Assessment, National Institute of Health Sciences

研究会 定例会

Reduction of chromosome damage in mouse mini-oocytes freeze-dried after treatment with
γ-tocotrienol
Hirokazu KUSAKABE

ワークショップ

1
3

P-100

Department of Biological Sciences, Asahikawa Medical University

P-101

ポスター

Development of the error-corrected sequencing-based genotoxicity evaluation method: A
collaborative study in JEMS/MMS
Yuki OTSUBO1, Sayaka HOSOI1, Takako HIROSE1, Shoji MATSUMURA1, Kazutoshi SAITO1,
Naohiro IKEDA2, Masaaki MIYAZAWA1, Naoki KOYAMA3, Akihiro KAWADE4, Atsushi HAKURA3,
Dai KAKIUCHI3, Shoji ASAKURA3, Yuki OKADA5, Takafumi KIMOTO6, Satsuki CHIKURA5,
Yukako MINAMI5, Junichi NAMEKAWA5, Takayoshi SUZUKI7, Kenichi MASUMURA8,
Kei-ichi SUGIYAMA7

シンポジウムP-98

1

Toyo University, 2Osaka Metropolitan University

47

人名索引

Effects of commonly used pesticides on AhR and drug-metabolizing enzymes
Mebae KOIKE1, Saki KANAMARU1, Minami SHIOZAWA1, Showa KOMATSU1, Rikako KARUBE1,
Masanobu KAWANISHI2, Sayoko HARASHIMA2, Takashi YAGI2, Kazuhiro SHIIZAKI1

プログラムP-102

Air Pollution and Endocrine Disruption:Evaluation by Yeast Reporter Assay
Yuto HANAICHI1, Sayoko HARASHIMA2, Yuya FUJITA2, Honami ONISHI2, Kentaro MORI2,
Mami MATANO2, Norio ITO3, Takashi YAGI1, Masanobu KAWANISHI1
1

Department of Biochemistry, Graduate School of Science, Osaka Metropolitan University,
Department of Biological Sciences, Graduate School of Science, Osaka Prefecture University,
3
Radiation Research Center, Osaka Public University
2

P-103

Program

The evaluation of DNA damage caused by particulate matters in the respiratory system
Yuya HIGAKI1, Raga ISHIKAWA2, Akiko HONDA1, Takamichi ICHINOSE2, Tomonari MATSUDA1,
Hirohisa TAKANO2, 3
1

Graduate School of Engineering, Kyoto University,
Graduate School of Global Environmental Studies, Kyoto University,
3
Institute for International Academic Research, Kyoto University of Advanced Science
2

P-104
受賞講演

Evaluation of the generation and properties of extracellular vesicles in pulmonary allergic
inflammation exacerbated by particulate matter
Ryota TAMADAI1, Raga ISHIKAWA2, Akiko HONDA1, Takamichi ICHINOSE2, Tomonari MATSUDA1,
Hirohisa TAKANO2, 3
1

Graduate School of Engineering, Kyoto University,
Graduate School of Global Environmental Studies, Kyoto University,
3
Institute for International Academic Research, Kyoto University of Advanced Science
2

特別講演

P-105

Prenatal exposure to organophosphate flame retardants and birth outcomes
Tian YING1, Lu QI1, Gao YU1, Wang HUI2
1

Department of Enviornment and Health, Shanghai Jiaotong University, China,
State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health,Shanghai Jiao Tong University School of Medicine, China2

P-106
シンポジウムEvaluation of agonist and antagonist activity of pesticides and other chemicals using yeast
express human thyroid hormone receptors
Mayuko NAKASHIMA1, Sayoko ITO-HARASHIMA2, 3, Masahiro OGAWA4, Junya KITAMOTO4,
Megumi TERADA4, Taku TANAKA4, Syota ASAI2, Shingo EBATA2, Takashi YAGI1, 2,
Masanobu KAWANISHI1, 2
1

Department of Biochemistry, Graduate School of Science, Osaka Metropolitan University,
Department of Biological Science, Graduate School of Science, Osaka Prefecture University,
3
Department of Applied Biological Chemistry, Graduate School of Agriculture, Osaka Metropolitan University,
4Life Science Research Institute, Kumiai Chemical Industry Co., Ltd
2

ポスター

P-107

Induction of epithelial/inflammatory cytokines by PM10
Tetsushi WATANABE1, Daisuke KAWAKAMI1, Mayu HAYASHI1, Io NOBUKIYO1, Fumika YANO1,
Takahiro MATSUMOTO1, Nobuyuki YAMAGISHI2
1

Department of Public Health, Kyoto Pharmaceutical University,
Faculty of Pharmaceutical Sciences, Setsunan University

2

研究会 定例会

P-108

RNA sequence analysis for cells exposed to polycyclic aromatic compounds exhibiting tumorpromoting activity
Kentaro MISAKI1, Takeji TAKAMURA2, Hirohisa TAKANO3, 4, Ken-ichiro INOUE1
1

School of Nursing, University of Shizuoka, 2Department of Applied Chemistry, Kanagawa Institute of Technology,
Institute for International Academic Research, Kyoto University of Advanced Science,4
Graduate School of Global Environmental Studies, Kyoto University
3

ワークショップ

P-109

A new radiation hormesis theory based on chemical reaction kinetics
Katsuhito KINO1, 2
1

Department of Nano Material and Bio Engineering, Faculty of Science and Engineering, Tokushima Bunri University,
Center for Advance Science and Engineering, Tokushima Bunri University

2

人名索引

48

Elucidating the mechanism of COVID-19 exacerbation by particulate matters targeting the
respiratory epithelial system
Raga ISHIKAWA1, Issei OMORI2, Tomoya SAGAWA1, 3, Akiko HONDA2, Tomoaki OKUDA4,
Hirohisa TAKANO1, 5
1

Graduate School of Global Environmental Studies, Kyoto University,
Graduate School of Engineering, Kyoto University,
3
Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine,4
Faculty of Science and Technology, Keio University,
5
Institute for International Academic Research, Kyoto University of Advanced Science

プログラム

P-110

2

Editing of involving multiple substitution, deletion, and insertion mutations using 5'-tailed
duplexHikaru AMAZAKI1, Hidehiko KAWAI1, 2, Hiroyuki KAMIYA1, 2, Kento SATOU1, 2, Taiki KATOU1, 2

Program

P-111

1

School of Pharmaceutical Sciences, Hiroshima University,
Graduate School of Biomedical and Health Sciences, Hiroshima University2

Detection of mouse antibody isotypes against ultrapure oxidation specific epitopes
Yoshihiro TAMAKI1, Jun NAKAMURA2, Haruna NAGAYOSHI3, Masanobu KAWANISHI1
1

Laboratory of Environmental Molecular Toxicology, Graduate School of Science, Osaka Metropolitan University,
Graduate School of Veterinary Sciences , Osaka Metropolitan University,
3
Division of Hygienic Chemistry, Osaka Institute of Public Health

受賞講演

P-112

2

JEMS・MMS collaborative study, thresholds for mutagens: Hormetic responses in the
micronucleus test
Shizuyo SUTOU1, Akiko KOEDA2, Kana KOMATSU2, Toshiyuki SHIRAGIKU3, Hiroshi SEKI4,
Toshiyuki KUDO1

特別講演

P-113

1

School of Pharmacy, Shujitsu University, 2Ina Research Inc., 3Otsuka Pharmaceutical Co., Ltd., 4BML Inc.

シンポジウムポスター
研究会 定例会
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人名索引49