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Phenotypes associated with this allele
Allele Pde6brd10
Symbol retinal degeneration 10
Allele MGI:2388259
NameAllele ID
Summary 1 genotype
Jump toAllelic Composition

Genetic Background

Genotype ID

hm1

Pde6brd10/Pde6brd10

B6.CXB1-Pde6brd10/J

MGI:3581193

Genotype
MGI:3581193
hm1AllelicPde6brd10/Pde6brd10Composition

Find Using the International Mouse Strain Resource
Mice (IMSR)

Genetic B6.CXB1Background Pde6brd10/J

Mouse lines carrying:Pde6brd10 mutation (1 available); any Pde6bmutation (121 available)

vision/eye
vision/eye phenotype ( J:122722 )N♀
♂

phenotype observed in females

Nnormal phenotype

phenotype observed in males

abnormal retinal vasculature morphology ( J:122722 )• sclerotic retinal vessels are observed at 4 weeks of age

abnormal retinal rod cell morphology ( J:122722 )retinal rod cell degeneration ( J:122722 )• rod photoreceptor cells start degenerating in the central retina at 16 days of age and in the peripheral retina at 20 days of age• by 60 days of age no photoreceptors remain

retinal outer nuclear layer degeneration ( J:122722 )• histological analyses show progressive retinal outer nuclear layer degeneration (ONL) beginning in the center at 16 days of age and spreading to
the periphery by 20 days of age

retinal degeneration ( J:117305 , J:122722 )• tauroursodeoxycholic acid slows onset of degeneration of retinal outer nuclear layers and photoreceptors (J:117305)• clinical abnormalities are observable at 4 weeks of age (J:122722)• histological analyses show progressive retinal outer nuclear layer degeneration (ONL) beginning in the center at 16 days of age and spreading to
the periphery by 20 days of age (J:122722)• by 60 days of age no ONL remains (J:122722)• nuclei counts in the ONL over time reflects progressive degeneration; inner nuclear layers are not affected (J:122722)• dark-reared mice showed no degeneration until 24 days of age with initial nuclei loss apparent at 30 days (J:122722)

abnormal eye electrophysiology ( J:117305 , J:122722 )• ERG a- and b- wave amplitudes are greater in mice treated with tauroursodeoxycholic acid (J:117305)• mice showed reduced rod and cone responses under both dark- and light-adapted conditions compared to wild-type (J:122722)• a small a-wave appeared only at the brightest flash intensity indicating loss of sensitivity in dark-adapted, 30 day old mice (J:122722)• the loss of cone function was not registered as fast by b-wave response from light-adapted compared to dark-adapted mice (J:122722)

cardiovascular systemabnormal retinal vasculature morphology ( J:122722 )• sclerotic retinal vessels are observed at 4 weeks of age

nervous systemabnormal retinal rod cell morphology ( J:122722 )retinal rod cell degeneration ( J:122722 )• rod photoreceptor cells start degenerating in the central retina at 16 days of age and in the peripheral retina at 20 days of age• by 60 days of age no photoreceptors remain

Mouse Models of Human Disease
retinitis pigmentosa

DO ID

OMIM ID(s)Ref(s)

DOID:10584 OMIM:PS268000 J:122722

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor
Biology (MTB), Gene Ontology (GO)Citing These Resources
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last database update
12/18/2019
MGI 6.14

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