Thrombosis and Haemostasis
Author Instructions

Thank you for contributing to Thrombosis and Haemostasis. Please read the instructions carefully and observe all
the directions given. Failure to do so may result in unnecessary delays in publishing your article.

SUBMISSION CHECKLISTAll manuscripts must be submitted at the following link:
https://mc.manuscriptcentral.com/th☐

AUTHOR INFORMATION- All authors: full name, department, affiliation- Corresponding author: full name, degrees, department, affiliation, mailing address,
telephone and fax number, e-mail address☐

MANUSCRIPT FILE
- Must be digital - hard copy submissions are not accepted☐

ABSTRACT AND KEYWORDS- See the section Article Types for word limit☐

REFERENCES- Cited sequentially in AMA style☐

FIGURES AND TABLES- Cited sequentially in the main document, must be saved separately from the main
document☐

ART FILES- Must be saved separately from the main document☐

PERMISSIONS- Required if you plan to reproduce content from a published source or include aphotograph of a patient- Patient permission forms available at www.thieme.com/journal-authors

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CONTENTS
MANUSCRIPT FORMAT ------------------------------------------------------------------------------------------------- 3
Article Types ---------------------------------------------------------------------------------------------------------- 3
General Guidelines --------------------------------------------------------------------------------------------------- 5
Title Page ------------------------------------------------------------------------------------------------------------- 6
Abstract and Keywords ---------------------------------------------------------------------------------------------- 6
Summary Table ------------------------------------------------------------------------------------------------------- 6
Visual Summary ------------------------------------------------------------------------------------------------------ 6
Animal experiments -------------------------------------------------------------------------------------------------- 6
General ---------------------------------------------------------------------------------------------------------------- 6
Acknowledgments---------------------------------------------------------------------------------------------------- 7
Conflict of Interest ---------------------------------------------------------------------------------------------------- 7
References ------------------------------------------------------------------------------------------------------------ 8
Figure Captions ------------------------------------------------------------------------------------------------------- 9
Tables ----------------------------------------------------------------------------------------------------------------- 9
DIGITAL ARTWORK PREPARATION ----------------------------------------------------------------------------------- 10
General Guidelines -------------------------------------------------------------------------------------------------- 10
Black-and-White Art ------------------------------------------------------------------------------------------------ 10
Color Art ------------------------------------------------------------------------------------------------------------- 10
Videos ---------------------------------------------------------------------------------------------------------------- 10
Art Labels ------------------------------------------------------------------------------------------------------------ 10
Visual Summary ----------------------------------------------------------------------------------------------------- 11
SUBMISSION PROCEDURE--------------------------------------------------------------------------------------------- 13
Open Access Option ------------------------------------------------------------------------------------------------- 13
Submission Procedure----------------------------------------------------------------------------------------------- 13
Preprint Server Statement ------------------------------------------------------------------------------------------ 13
Revision Procedure -------------------------------------------------------------------------------------------------- 13
PRODUCTION PROCEDURE-------------------------------------------------------------------------------------------- 15
Page Proofs ---------------------------------------------------------------------------------------------------------- 15
Page Charges --------------------------------------------------------------------------------------------------------- 15
Color figures --------------------------------------------------------------------------------------------------------- 15
Author Names ------------------------------------------------------------------------------------------------------- 15
POLICY STATEMENTS -------------------------------------------------------------------------------------------------- 16
Statement on Liability ----------------------------------------------------------------------------------------------- 16
Definition of Authorship -------------------------------------------------------------------------------------------- 16
Copyright Statement ------------------------------------------------------------------------------------------------ 16
Statement of Ethics -------------------------------------------------------------------------------------------------- 16
Registration of Clinical Trials --------------------------------------------------------------------------------------- 16
Declaration of Helsinki ---------------------------------------------------------------------------------------------- 17
Patient Permission Policy and Thieme GDPR Policy --------------------------------------------------------------- 17
EDITORIAL CONTACTS ------------------------------------------------------------------------------------------------- 18

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MANUSCRIPT FORMAT
Article Types
The following graph shows what types of articles are accepted for publication, and what requirement they may
have.

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Tables/Figures Limit

ReferencesLimit

No limit, but onlineonly suppl. material isencouraged

Up to 50
references

No limit, but onlineonly suppl. material isencouraged
No limit, but onlineonly suppl. material isencouraged
No limit, but onlineonly suppl. material isencouraged

Up to 50
references

Article Type

Abstract Limit

Keywords
Limit

Original Article(up to 5,000
words)Up to 250 words

Up to 5
keywords

150 characters

Trial Protocol
Design Paper

Up to 250 words

Up to 5
keywords

150 characters

Editorials (up to
500 words)

N/A

N/A

150 characters

Invited Pro Article

Up to 250 words

Up to 5
keywords

150 characters

Invited Contra
ArticleUp to 250 words

Up to 5
keywords

150 characters

No limit, but onlineonly suppl. material isencouraged

Up to 25
references

Review Article

Up to 250 words

Up to 5
keywords

150 characters

No limit, but onlineonly suppl. material isencouraged

Up to 150
references

Up to 1 tables/figures

Up to 25
references

Up to 2 figures withmaximum of 8 panels

Up to 5references

Title Limit

Letters to the
Editor(up to 1,000
words)

N/A

N/A

150 characters

T&H Images(up to 400 words)

Up to 250 words

Up to 5
keywords

Up to 25 words

Up to 25
references
Up to 25
references

Original Article: Upon submission of manuscripts, authors should indicate which of the following categories
comes closest to the contents of their basic, translational or clinical study: Coagulation and Fibrinolysis/
Platelets, Cellular Haemostasis and Signalling/ Blood Cells, Endothelium, Inflammation and Infection/ New
Technologies, Diagnostic Tools and Drugs/ Stroke, Systemic or Venous Thromboembolism/ Atherosclerosis
and Ischaemic Disease. Regular articles may not exceed 5,000 words (ca. 35,000 characters), excludingtables, figure legends and references. The Editors-in-Chief may request reductions in manuscript length if it
is considered too long for its message. However, manuscripts exceeding this limit may be considered if they
are of exceptional quality. Original articles should have no more than 50 references. Supplementary material
may be submitted for online only publication.
Trial Protocol Design Paper: These articles must include a comprehensive review of the published literature[which should be summarised in succinct table(s)], and good justification on basis of prior evidence on theneed for the new trial. The trial also requires a clinical trials registration number (seewww.clinicaltrials.gov).
Editorials: Editorials include commentaries on upcoming articles in the Journal (invited or from the Editorin-Chief). Articles are brief overviews of approx. 500 words that undergo a short review process.

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Invited ‘Pro’ and ‘Contra’ articles: Perspectives and new developments (e.g. in basic research or certain
therapies) as well as articles on selected topics and should be limited to three printed pages in the Journal.
These contributions undergo a short review process.
Review Article: The aim of invited and submitted reviews is to survey recent developments in the field on
topics in basic research and clinical studies in vascular biology and medicine. Review articles may besolicited by the Editor-in-Chief, but individual suggestions are also welcome. Authors should contact the
Editorial Office before submitting a Review article. Review articles should have no more than 150 references.
Letters to the Editor: Letters include short highlights of basic or clinical research in vascular biology andmedicine that are significant enough for dissemination in Thrombosis and Haemostasis; they also include
Case Reports that are unusual or truly unique case reports that would advance our understanding of the
field. Letters should not exceed 1,000 words (ca. 7,000 characters). They should include up to 1 figure or 1
table, no supplemental data and no abstract. and they undergo the usual review process.
T&H Images: This category includes images in both basic and/or clinical science that represent a uniqueobservation or a first detection of a novel mechanism. Any imaging modality may be used but of course
state-of-the-art methodology is preferential. Submit one or two images with a maximum of 8 panels in total.
Please refer to Digital Artwork Preparation section. It is encouraged to upload videos for online linkage to thefigures. The text should be as short as possible, focusing on the image rather than on methodology andshould be no longer than 300-400 words maximum; excluding title (max. 100 characters), author (max. 8)
and affiliations list, reference list (max. 5) and funding resources, but including figure legend(s). Figurelegends must be self-explanatory. Note: image processing is only allowed when essential for the
methodology and not just for improvement of the overall appearance of the image. When applied, all image
processing steps must be declared in the manuscript. Only add references when really required for correctinterpretation of the shown data in the manuscript.

4General Guidelines
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You must submit a digital copy of your manuscript. Hard copy submissions are not accepted.
Keep the format of your manuscript simple and clear. We will set your manuscript according to ourstyle—do not try to “design” the document.
The manuscript, including the title page, abstract and keywords, text, references, and figure legends
should be typewritten, double-spaced in 12-point font with 1-inch margins all around and saved as one
file.
Each figure should be either saved as a separate file. Do not embed figures in the text flow.
Keep abbreviations to a minimum and be sure to explain all of them the first time they are used in thetext.
The manuscripts should be written in consistent British or American English.
The authors should use Système International (SI) measurements. For clarity, nonmetric equivalents
may be included in parentheses following the SI measurements.
Use generic names for drugs. You may cite proprietary names in parentheses along with the name andlocation of the manufacturer.
Credit suppliers and manufacturers of equipment, drugs, and other brand-name material mentioned in
the manuscript within parentheses, giving the company name and primary location.

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MANUSCRIPT FORMAT continued
Title Page••

This journal adheres to a single-blinded peer-review policy. The title page should be included in themain document.
The title page should list the article title and the corresponding author’s full name, degree, title,
department, affiliation, mailing address, e-mail address, and telephone and fax numbers. It should also
list the full name, department, and affiliation of every co-author.

Abstract and Keywords
See the section Article Types for word limits.
The abstract should briefly outline the content of the article and any conclusions it may reach. The keywords
should be words a reader would be likely to use in searching for the content of the article.
Summary Table
Original Articles should include an extra table with two parts: 1. 'What is known on this topic' and 2. 'What does
this paper add?'. This should be two or three bullet points for each, with one or two short sentences for eachbullet point. The objective of this is to provide the reader with a brief, quick and focused summary of your workin the perspective of other data as well as the clinical implications.
Visual Summary
You should accompany each Original article and Review submission by a Visual Summary. It should besubmitted as a separate file with file name ‘Visual Summary’. Please refer to the specific instructions under“Digital Artwork Preparation”. Outstanding Visual Summaries may be selected to appear on the Cover of T&H.
Animal experiments
Document the species, strain, genetic background (amount of backcrossing when applicable), sex and number of
each animal used. When possible, preclinical studies should include both sexes, and data should be presented
distinctly for each sex to potentially identify sex differences. Pre-clinical studies proposing only one sex should
be strongly justified from the scientific literature, preliminary data or other relevant considerations. The sex ofanimals used for tissue and cell should also be documented.
General
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Please clearly distinguish the hierarchy of headings within the manuscript by using capital letters,
underline, italic, and bold styles as necessary.
As needed, use italic, superscripts, subscripts, and boldface, but otherwise do not use multiple fonts andfont sizes.
Do not insert page or section breaks except where noted in the Author Instructions.
Use hard returns (the Enter key) only at the end of a paragraph, not at the end of a line. Allow lines oftext to break automatically in your word-processing software. Do not justify your text.
Use only one space, not two, after periods.
Create tables using the Table function in Microsoft Word and upload them as separate files.

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Acknowledgments
The source of any financial support received and recognition of personal assistance for the work being publishedshould be indicated at the end of the article, just before the Reference section, under the heading
Acknowledgments.

Conflict of Interest
All authors (including corresponding and co-authors associated with the manuscript) must make a formal
statement at the time of submission indicating any potential conflict of interest that might constitute anembarrassment to any of the authors if it were not to be declared and were to emerge after publication. Suchconflicts might include, but are not limited to, shareholding in or receipt of a grant or consultancy fee from acompany whose product features in the submitted manuscript or which manufactures a competing product.
Should the article be accepted for publication, this information will be published with the paper.
Types of conflicts include: Consulting, Royalties, Research Support, Institutional Support, Ownership,
Stock/Options, Speakers Bureau, and Fellowship Support. Any commercial entity whose products are described,
reviewed, evaluated, or compared in the manuscript, except for those disclosed in the Acknowledgments section,
are potential conflicts.
This journal follows the guidelines of the International Committee of Medical Journal Editors and an ICMJE
disclosure of potential conflicts of interest (COI) form must be submitted for each author at the time ofmanuscript submission. Forms must be submitted even if there is no conflict of interest. It is the responsibility of
the corresponding author to ensure that all authors adhere to this policy prior to submission.
A conflict of interest statement must also be included in the manuscript after any "Acknowledgements" and"Funding" sections and should summarize all aspects of any conflicts of interest included on the ICMJE form. If
there is no conflict of interest, authors must include 'Conflict of Interest: none declared'.
Please click http://www.icmje.org/conflicts-of-interest to download a Conflict of Interest form. The disclosure
information is important in article processing. If the provided forms are incomplete or missing, it can causedelays in publishing of article.
!!Important if you chose the Accepted Manuscript Service!!
Please note that the information which will be displayed early online on PubMed and on the Thieme homepage(including title, abstract, keywords, authors, affiliations, etc...) will be that which has been entered in thedesignated fields at the time of submission. Please make sure that information entered in those fields is correct
in your revised document. Should the information in the main document differ, changes can only be made at
proof stage.

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MANUSCRIPT FORMAT continued
References
References should be the most recent and pertinent literature available. It is essential that they are complete andthoroughly checked. If the reference information is incomplete, good online sites to search for full details are the
National Library of Medicine: www.nlm.nih.gov; Books in Print: www.booksinprint.com; PubMed:
www.ncbi.nlm.nih.gov/PubMed/; or individual publisher Web sites.
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References must be listed in AMA style, using Index Medicus journal title abbreviations.
References follow the article text. Insert a page break between the end of text and the start ofreferences.
References must be cited sequentially (NOT alphabetically) in the text using superscript numbers.
By way of exception to AMA style, do not italicize book titles or journal title abbreviations and do not
put a period at the end of a reference.
List all author names, up to and including six names. For more than six authors, list the first threefollowed by et al.
References should be styled per the following examples:1.

Citing a journal article:
Newburger JW, Takahashi M, Burns JC, et al. The treatment of Kawasaki syndrome withintravenous gamma-globulin. N Engl J Med 1986;315:341–347

2.

Citing a chapter in a book:
Toma H. Takayasu’s arteritis. In: Novick A, Scoble J, Hamilton G, eds. Renal Vascular Disease.
Philadelphia: WB Saunders; 1995:47–62

3.

Citing a book:
Stryer L. Biochemistry. 2nd ed. San Francisco: WH Freeman; 1981:559–596

4.

Citing a thesis:
Stern I. Hemorrhagic Complications of Anticoagulant Therapy [Ph.D. dissertation]. Evanston, IL:
Northwestern University; 1994

5.

Citing a government publication:
Food and Drug Administration. Jin Bu Huan Herbal Tablets. Rockville, MD: National Press Office;April 15, 1994. Talk Paper T94-22

6.

Citing an online article:
Rosenthal S, Chen R, Hadler S. The safety of acelluler pertussis vaccine vs whole-cell pertussis
vaccine [abstract]. Arch Pediatr Adolesc Med [serial online]. 1996;150:457–460. Available at:
http://www.ama-assn.org/sci-pubs/journals/archive/ajdc/vol_150/no_5/abstract/htm. Accessed
November 10, 1996

7.

Citing a symposium article:
Eisenberg J. Market forces and physician workforce reform: why they may not work. Paper
presented at: Annual Meeting of the Association of American Medical Colleges; October 28,
1995; Washington, DC

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MANUSCRIPT FORMAT continued
Figure Captions
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Figures include photographs or radiographs, drawings, graphs, bar charts, flow charts, and pathways, but
NOT lists or tables.
Figures must be cited sequentially in the text. Number all figures (and corresponding figure captions)sequentially in the order they are cited in the text.
Figure captions should be written after the reference list. Insert a page break between the end of references
and the start of figure captions.
Figure captions should include a description of the figure and/or each lettered part (A, B, etc.) and of any
portions of the figure highlighted by arrows, arrowheads, asterisks, etc.
For a figure borrowed or adapted from another publication (used with permission), add a credit line inparentheses at the end of each figure legend. This credit line should be a complete bibliographic listing of thesource publication (as a reference), or other credit line as supplied by the copyright holder. For example(Reprinted with permission from Calfee DR, Wispelwey B. Brain abscess. Semin Neurol 2000;20:357.)

Tables
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Data given in tables should be commented on but not repeated in the text. Be sure that lists or columns ofrelated data are composed in a word-processing program like the rest of the text.
Do not intersperse tables in the text. Tables should appear after the figure captions. Insert a page break
between the end of the figure captions and the start of the tables.
Tables must be double-spaced and numbered in the same sequence they are cited in the text. A short
descriptive title should be provided for each table.
If a table contains artwork, supply the artwork separately as a digital file.
For tables borrowed or adapted from another publication (used with permission), add a credit line as thefirst footnote beneath each table. This credit line should be a complete bibliographical listing of the source
publication (as a reference), or other credit line as supplied by the copyright holder. For example, “Reprinted
with permission from Calfee DR, Wispelwey B. Brain abscess. Semin Neurol 2000;20:357.” (“Data from . . .”or “Adapted from . . .” may also be used, as appropriate.)
Other footnotes for tables should be indicated in the table using superscript letters in alphabetical order.
Any abbreviations used in the table should be explained at the end of the table in a footnote.

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DIGITAL ARTWORK PREPARATION
General Guidelines
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It is best to use Adobe Photoshop to create and save images, and Adobe Illustrator for line art and labels.
Only upload Figures in TIF, PNG or JPG Format.
Save each figure in a separate file.
Do not compress files.
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All black-and-white and color artwork should be at a resolution of 300 dpi (dots per inch) in TIFF format.
Line art should be 1,200 dpi in EPS or TIFF format. Contact the Production Editor at Thieme if you are
unsure of the final size.
It is preferable for figures to be cropped to their final size (approximately 3½ inches for a single column and
up to 7 inches for a double column), or larger, and in the correct orientation. If art is submitted smaller andthen has to be enlarged, its resolution (dpi) and clarity will decrease.
Please add a white background to each Figure so that it displays correctly in the generated PDF proof.
Note: Lower resolutions (less than 300 dpi) and JPEG format (.jpg extension) for grayscale and color artwork
are strongly discouraged due to the poor quality they yield in printing, which requires 300 dpi resolution for
sharp, clear, detailed images. JPEG format, by definition, is a lower resolution (compressed) format designed
for quick upload on computer screens.

Black-and-White Art•••

Black-and-white artwork can be halftone (or grayscale) photographs, radiographs, drawings, line art,
graphs, and flowcharts. Thieme will only accept digital artwork.
If possible, do not send color art for conversion to black-and-white. Do the conversion yourself so that you
can check the results and confirm in advance that no critical details are lost or obscured by the change toblack-and-white.
For best results, line art should be black on a white background. Lines and type should be clean and evenly
dark. Avoid screens or cross-hatching, as they can darken or be uneven in printing and lead to unacceptable
printing quality.

Color Art•

All color artwork should be saved in CMYK, not RGB.

Videos••

The following formats are acceptable: *.avi, *.mov and *.mpg.
For supplementary videos, the length should not exceed 4 minutes, and a legend of no more than 40 words
per video or per sequence is required (it should also be included in the main document).
If including a voice over, it must be in clear English. Be precise, informative, and clear in your speech. Re-record
audio in post-production for sound quality.
Art Labels
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Arrows, asterisks, and arrowheads (or other markers) should be white in dark or black areas and black inlight or white areas, and large in size. If not, these highlighting marks may become difficult to see when
figures are reduced in size during the typesetting process.
Use 1-point (or thicker) rules and leader lines.
Capitalize the first word of each label and all proper nouns. Consider using all capitals if you need a higher
level of labels.
Where there are alternate terms or spellings for a named structure, use the most common one and makesure it is consistent with what is used in the text.
Avoid using multiple fonts and font sizes for the labels; use only one or two sizes of a serif font.

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Visual Summary
The Visual Summary should convey the main message of your manuscript in a clear and concise manner so thatreaders can grasp its contents and relevance at a glance. With the manuscript’s title, it is what will capture theinterest of your readers and draw them to read the whole paper.
It should:-

be one single panel image file.
be distinct from any Figures within the manuscript.
be self-explanatory and not contain long text.
have a large enough font size.
fit a 16:9 aspect ratio, at least 120mm wide, minimum resolution of 300dpi.
be accompanied by a short legend.

Useful (free) resources for creating Visual Summaries:
Servier Medical Art smart.servier.com : free of charge and comprehensive resource for anatomy, biology, andmedical illustrations.
Flaticon flaticon.com : useful database of free icons available in different formats.
Somersault 1824 somersault1824.com/science-illustrations : ‘pay-what-you-can’ professional scientificillustrations.
Public Health Image Library phil.cdc.gov : images from the Center for Disease Control and Prevention (CDC) in
Atlanta, USA. Images are often in the public domain, credit is requested.
Wikimedia commons commons.wikimedia.org : can be in the public domain.
Scienceimage scienceimage.csiro.au: free images from the Commonwealth Scientific and Industrial Research
Organisation (CSIRO) in Australia.
Pixabay pixabay.com, Pexels pexels.com, Unsplash unsplash.com, Freerange freerangestock.com – large bank offree diagrams, illustrations and pictures.
Please make sure you comply with the licensing of the image you are using. Licensing terms and attribution
requirements on the respective sources.

Examples of Visual Summaries in published articles

Example 1: Targeting von Willebrand Factor in Ischaemic
Stroke: Focus on Clinical Evidence. N. Buchtele, M.
Schwameis, J.C. Gilbert, C. Schörgenhofer, B. Jilma. 2018;
118(06): 959-978.

Example 2: Optimizing Stroke and Bleeding Risk Assessment
in Patients with Atrial Fibrillation: A Balance of Evidence,
Practicality and Precision. M. Proietti, N. Mujovic, T.S.
Potpara. 2018; 118(12): 2014-201711

Examples of Visual Summaries in published articles contd.

Example 3: Oh Heavy Burden: Recognizing the Risk of
Venous Thromboembolism in Women Undergoing Assisted
Reproduction. G. Piazza. 2018; 118(12): 2011-2013

Example 5: Dual Antiplatelet or Dual Antithrombotic
Therapy for Secondary Prevention in High-Risk Patients with
Stable Coronary Artery Disease? W. Sumaya, T. Geisler, S.D.
Kristensen, R.F. Storey. 2019; 119(10): 1583-1589

Example 4: Total Thrombus-Formation Analysis System (TTAS): Clinical Application of Quantitative Analysis ofThrombus Formation in Cardiovascular Disease. K. Kaikita, K.
Hosokawa, J.R. Dahlen, K. Tsujita. 2019; 119(10): 1554-1562

Example 6: Lysophosphatidylcholine in Platelet
Microvesicles: The Grease for Cardiovascular Disease. R.R.
Koenen. 2019; 119(08): 1202-1204

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SUBMISSION PROCEDUREOpen Access Option
Authors of articles for all Thieme subscription journals – including Thrombosis and Haemostasis - have theoption of paying an article processing charge (APC) so that their articles will be published on an Open Accessbasis. Learn more about Thieme’s Open Access program by visiting https://www.thieme.com/en-us/who-weserve/authors/journals/open-access. For the current pricing, please go to “APC” and select “Price List” ("Hybrid
Open Access" price applies to this journal).

Submission Procedure
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Consult the checklist on the first page of this document to ensure that you are ready to submit yourmanuscript.
Please note: There are no submission charges to submit your manuscript to this journal.
Manuscripts must be submitted electronically at the following link: http://mc.manuscriptcentral.com/thEach manuscript must be accompanied by a cover letter.
Always review your manuscript before submitting it. You may stop a submission at any phase and save it tosubmit later. After submission, you will receive a confirmation email. You can also check the status of yourmanuscript by logging in to the submission system.
All manuscript submissions will be processed via the online system. Decisions and correspondence from theCentral Editorial Office, Editors-in-Chief (Basic Science/Clinical Studies) and Section Editors will be
communicated via e-mail.
Referees: To facilitate and hasten the review process, prospective authors are encouraged to suggest up to 4
suitable referees for the submitted work. Authors may also choose to name 4 referees, whom they would
wish to exclude from the review process.

Preprint Server Statement
Thrombosis and Haemostasis encourages the submission of manuscripts that have been deposited in an initial
draft version in preprint repositories such as Research Square, arXiv, and medRxiv. Drafts of short conference
abstracts or degree theses posted on the website of the degree-granting institution, and draft manuscripts
deposited on authors’ or institutional websites are also welcome. All other prior publication is forbidden.
During submission, authors should (1) note use of the preprint repository in the cover letter, (2) state what
adjustments and/or updates the draft has undergone between deposition and submission and (3) cite thepreprint, including the DOI, as a reference in the manuscript.
After submission to the journal, and until a final decision has been made, authors are discouraged from
depositing versions of their manuscript as preprints. Upon publication authors should add a link from thepreprint to the published article. Twelve months after publication, authors can update the preprint with theaccepted manuscript.

Revision Procedure•••

Should the editors decide that your article requires a revision, you will need to make the changes via a wordprocessing program and resubmit it electronically.
Log In to the submission system and find your article, which will be marked for revision.
The best way to make revisions to your manuscript is by enabling the Track Changes mode in Microsoft
Word, which will automatically highlight and mark up revised text. Please submit both a marked up copy
and a clean copy of your revised manuscript to the submission system.

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Your original files will still be available after you upload your revised manuscript, so you should delete any
redundant files before completing the submission.
You will also be provided space in which to respond to the reviewers’ and editors’ comments. Please be as
specific as possible in your response.

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PRODUCTION PROCEDURE
Page Proofs
Page proofs will be sent to you via email. The proofs will be in a PDF file format, which should be opened using
Acrobat Reader software. You will receive further instructions with your proofs. Take this opportunity to checkthe typeset text for typographic and related errors. Elective alterations are difficult to accommodate owing to theassociated time and expense of introducing them. Therefore, please be sure that when you submit yourmanuscript, it is accurate, complete, and final.
Page Charges
A fee of US $50 (USA + Canada) or €40 (Europe and overseas) per printed page is charged by the publisher, forRegular Articles, and other articles that were not invited, once the manuscript has been accepted for publication.
The fee also applies to Letters to the Editor, which exceed one page. There is no page charge for the category T&H
Images.
Color figures
Colour figures will be charged to the author at €450 for the first figure. Any further figures are free of charge.
Authors are not charged for figures chosen to appear on the cover.
Author Names
This regards the addition, deletion, or rearrangement of author names in the authorship of accepted
manuscripts: Before the accepted manuscript is published online or in print, any requests to add or remove an
author, or to rearrange the author names, must be sent to the Managing Editor of the journal from thecorresponding author of the accepted manuscript and must include: 1. the reason the name should be added or
removed, or the author names rearranged and 2. written confirmation (e-mail, fax, letter) from all authors thatthey agree with the addition, removal or rearrangement. In the case of addition or removal of authors, thisincludes confirmation from the author being added or removed. Requests that are not sent by the corresponding
author will be forwarded by the Managing Editor to the corresponding author, who must follow the procedure as
described above. Note that: 1. Journal Managers will inform the Journal Editors of any such requests and 2.
publication of the accepted manuscript online or in print is suspended until authorship has been agreed. Afterthe accepted manuscript is published, any requests to add, delete, or rearrange author names will follow thesame policies as noted above and result in a corrigendum.

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POLICY STATEMENTS
Statement on Liability
The legislation on product liability makes increased demands on the duty of care to be exercised by authors ofscientific research and medical publications. This applies in particular to papers and publications containing
therapeutic directions or instructions and doses or dosage schedules. We therefore request you to examine withparticular care, also in your own interest, the factual correctness of the contents of your manuscript once it has
been copyedited and returned to you in the form of galley proofs. The responsibility for the correctness of dataand statements made in the manuscript rests entirely with the author.
Definition of Authorship
Authorship credit should be based on criteria established by the International Committee of Medical Journal
Editors. Each author should have made the following contributions towards the completion of the manuscript:
1.
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3.

Substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data
Drafting the article or revising it critically for important intellectual content
Final approval of the version to be published

Copyright Statement
Submitted manuscripts must represent original research not previously published nor being considered for
publication elsewhere. The editors and Thieme combat plagiarism, double publication, and scientific misconduct
with the software CrossCheck powered by iThenticate. Your manuscript may be subject to an investigation andretraction if plagiarism is suspected.
If you plan to reproduce text, tables, or figures from a published source, you must first obtain written permission
from the copyright holder (usually the publisher). This is required even if the material is from your own
published work. For material never before published and given to you by another person, you must obtain
permission from that person. Serious delays to publication can be incurred if permissions are not obtained.
As the author, it is your responsibility to obtain all permissions, pay any permission fees, furnish copies of
permissions to Thieme with your manuscript, and include a credit line at the end of the figure caption, beneaththe table, or in a text footnote.
Upon publication of an article, all rights are held by the publishers, including the rights to reproduce all or part ofany publication. The reproduction of articles or illustrations without prior consent from the publisher isprohibited.
Statement of Ethics
This journal adheres to the ethical standards described by the Committee on Publication Ethics and theInternational Committee of Medical Journal Editors. Authors are expected to adhere to these standards.
For all manuscripts reporting data from studies involving human or animal participants, formal review andapproval, or formal review and waiver (exemption), by an appropriate institutional review board (IRB) or ethics
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the registry and registry number.
Registration of Clinical Trials
All submissions which report on new clinical trials should provide evidence that the trial is registered with oneof the ICMJE-approved databases [ClinicalTrials.gov]. The reporting of randomised clinical trials must conform to16

the revised CONSORT statement [Ann Intern Med 2001; 134: 663–694]. Observational studies should comply
with STROBE recommendations [PLoS Medicine 2997; 4: 1628–1654].
Declaration of Helsinki
Authors are required to honour the ethical principles for medical research involving human subjects as set out in
Declaration of Helsinki.

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The personal rights of people who are recognizable on images must be protected. Please provide a writtenconsent form for publication signed by every recognizable person. For persons under 18 years of age / persons
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regulations, please contact us before submitting your manuscript.

17

EDITORIAL CONTACTS
Please contact the Editors or Thieme Publishers with any questions.
Editor in Chief
Christian Weber, MD (Basic Science)
Institute for Cardiovascular Prevention
Ludwig-Maxmilians-University (LMU)
Munich, Germany
christian.weber@med.uni-muenchen.de
Gregory Y. H. Lip, MD, FRCP, FESC, FACC (Clinical Studies)
Liverpool Centre for Cardiovascular Science
University of Liverpool
Liverpool, UK
gregory.lip@liverpool.ac.uk
Editorial Office - Thrombosis and Haemostasis
Dr. Anne Rigby
Institute for Cardiovascular Prevention
LMU Munich, Germany
Tel: +49-(0)89-4400-54670 /Fax: +49-(0)89-4400-54676
e-mail: arigby@med.lmu.de
Thieme Publishers
th@thieme.com
Thieme Publishers – Project Manager Journals
Dr. Elinor Switzer
Rüdigerstr. 14
70469 Stuttgart, Germany
Tel: +49 711 8931 230 / Fax: +49 711 8931 323
e-mail: Elinor.Switzer@thieme.de

Last Updated: January 202418