Excitatory synapse pathway

Tiam

p190RhoGAP

CaM

CaM

Calcineurin

Src

Ub

Src
PP1

BetaPIX

Ca2+C

Ca2+ channel

AKAP79/150

AMPA RUb

NFAT

Src MaGUK Ub

AKAP79/150 PSD95ArcPKA Calcineurin

Ub

Kainate R

Ub

mGluR

Spectrin

Kalirin7

Rho
GDP

CaMKIIRASGRFRAS

Homer
ProSAP/ShankCortacin
RAS

RAF
GTP

GTP
Rac

Rac

NFκB

Spinogenesis

Actin
ERK

GDP

Actin
reorganization

Synapse development,function, and plasticity

PSD95
Homer

GDP

GTP

Axonalguidance

CSP α

Neurotransmitters

SynCamCa2+2+CaMKI CaMKKGSK3 βCa2+ACh RPKA Calcineurin
Ca

ClathrinCa2+βCat

SynCamEphB

SyndecanNMDA R

Kalirin7

AXIN
APC

CN R

SNAP25

MUNC13revinCa2+ channel

Syntenin

Vav2

Rho

SNAP25

tob

FzR

WNT

APC

CN R

EphrinB

nCadherin
nCadherin

Neurexin

PSD95

Src
Ephexin1

LRRTM

Neuroligin

NetrinG

LAR

EphA

EphrinA

MUNC18NGL

Syntaxin

in
rev
tob
ap
ny
S
Syntaxin

ap

CASK

mGluR
G i/o

GKAP/SAPAP

Syn

SynaptotagminSV
2(2A,2B,2C)

B/3
A/3

5/3

Velis

inrev

tob

apRab

Early endosome

RIM
MINTsin

apSyn

Rab3

PiccoloSynysi

Synptogyrin

PRA 1

SynGapBassoonphOP
SV

PRA 1SCAMP

Synapticvesicle

n1aptoActin

βVti
Syn

Neuronal survival

MEKReceptor traﬃcking

Synaptic signaling

NMDA Receptor

AMPA Receptor

Kainate Receptor

Group I mGlu receptor

Group II mGlu receptor

Group III mGlu receptor- Agonist: NMDA (ab120052)- Antagonist: D-AP5 (ab120003)- Primary antibody: Anti-NMDAR2B
antibody (ab65783)- Agonist: (S)-AMPA (ab120005)- Antagonist: NBQX (ab120045)- Primary antibody: Anti-Glutamate Receptor 1 (AMPA subtype)antibody [EPR5479] (ab109450)- Agonist: Kainic acid (ab120100)- Antagonist: CNQX disodium salt
(ab120044)- Primary antibody: Anti-GRIK2
antibody [EPR6307] (ab124702)- Agonist: (R,S)-3,5-DHPG (ab120020)- Antagonist: MPEP hydrochloride(ab120008)- Primary antibody: Anti-Metabotropic
Glutamate Receptor 5 antibody[EPR2425Y] (ab76316)- Agonist: LY 379268 (ab120196)- Antagonist: (S)-MCPG (ab120059)- Primary antibody:Anti-Metabotropic GlutamateReceptor 2 antibody [EPR8975](ab150387)- Agonist: L-AP4 (ab120002)- Antagonist: MMPIP (120245)- Primary antibody: Anti-Metabotropic Glutamate Receptor 4antibody (ab53088)

PW0043 2024/01 A

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Agonists, antagonists, activators and inhibitors
NMDA receptor agonists and antagonists
Name

Description

PurityCitations

Product code

D-AP5

NMDA glutamate site antagonist

> 99%

125

ab120003

NMDA

Excitotoxic amino acid

AMPA receptor agonists and antagonists(S)-AMPANBQX

Kainic acid

CNQX disodium salt(R,S)-3,5-DHPGMPEP hydrochloride

11ab120005

Prototypic kainate receptor agonist> 99%

31ab120100

Group I mGlu receptor agonist> 98%

3ab120020

Systemically active group II mGlu agonist> 99%

5ab120196

Selective group III mGlu agonist> 99%

16ab120002> 99%

Potent, selective mGlu5 antagonist

Group II mGlu receptor agonists and antagonists
LY 379268(S)-MCPG

Group I / II mGlu antagonist

Group III mGlu receptor agonists and antagonists
L-AP4MMPIPab120052> 98%

AMPA / kainate antagonist

Group I mGlu receptor agonists and antagonists

10AMPA agonist

AMPA / kainate antagonist

Kainate receptor agonists and antagonists> 99%

mGlu7 allosteric antagonist

88> 99%12> 99%21> 98%

9> 98%

2ab120045

ab120044

ab120008

ab120059

ab120245

Primary antibodies
NMDA receptor primary antibodies
Name

Description

Tested applications

Species reactivity

Product code

Rabbit monoclonal to Glutamate Receptor 1 (AMPA subtype)[EPR5479]

WB, IP, IHC

Human, Mouse, Rat

ab109450

Anti-GRIK2 antibody [EPR6307]

Rabbit monoclonal to GRIK2 [EPR6307]

WB, IHC

Human, Mouse, Ratab124702

Anti-Metabotropic Glutamate Receptor 5 antibody [EPR2425Y]

Rabbit monoclonal to Metabotropic Glutamate Receptor 5[EPR2425Y]

WB, IHC, ICC/IF, Flow Cyt Human, Mouse, Rat

ab76316

Rabbit monoclonal to Metabotropic Glutamate Receptor 2[EPR8975]

WB, IHC, ICC/IF

Human, Mouse, Rat

ab150387

Rabbit polyclonal to Metabotropic Glutamate Receptor 4

ELISA, WB, IHC, ICC/IF

Human, Mouse, Rat, Chicken, Cat

ab53088

Anti-NMDAR2B antibody

Rabbit polyclonal to NMDAR2B

AMPA receptor primary antibodies

Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR5479]
Kainate receptor primary antibodies
Group I mGlu receptor primary antibodies

Group II mGlu receptor primary antibodies

Anti-Metabotropic Glutamate Receptor 2 antibody [EPR8975]
Group III mGlu receptor primary antibodies

Anti-Metabotropic Glutamate Receptor 4 antibody
Just-Add-Water: water soluble to at least 5mM or above

Product also available as 1 mL water soluble pack

Variation of this product available as 1 mL water soluble packBrowse the full range of glutamate-related products at: abcam.com/glutamate-products

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WB, IP, IHC, ICC/IF

Human, Mouse, Rat, Chicken, Xenopus ab65783

Blocking peptide available