Program
Sunday, April 12
18:00 - 21:00

Registration

19:00 - 21:00

Welcome Reception

Monday, April 13
08:30 - 08:45

Opening Remarks
Ryo Nishikawa（Japan）

08:45 - 10:15

Session 1 Epidemiology
Moderator: Matthew Ming Kong Shing（Hong Kong SAR, China）

10:20 - 11:35

O-01

Epidemiology of Intracranial Germ Cell Tumours
Eric Bouffet（Canada）

O-02

CNS Germ Cell Tumors: an Indian Perspective
Aanchal Kakkar（India）

O-03

Population-based Incidence of Intracranial Germ Cell Tumor among Children inTaiwan, 1996–2010
Yen-Lin Liu（Taiwan）

O-04

Correlation of the Clinical Significance of Population-based, Multicenter-based andSingle Hospital Series Survey of Intracranial Germ Cell Tumors
Tai-Tong Wong（Taiwan）

O-05

Population Based Epidemiologic Data of GCTs in Korea
Seung Hoon Lee（Korea）

O-06

Incidence of Primary Central Nervous System Germ Cell Tumors in Kumamoto
Prefecture in Southern Part of Japan: a 25 Years Study
Keishi Makino（Japan）

Session 2 Neurology/Long-term Sequelae/Proton Therapy
Moderators: Ute Bartels（Canada）, Hidefumi Aoyama（Japan）
O-07

Long-term Outcome of Germinoma, a Single Institution Report
Masanori Yoshida（Japan）O-08

Long-term Clinical Outcomes of Germ Cell Tumors
Kenichiro Matsuda（Japan）

O-09

Factors Affecting Functional Outcomes in Long-term Survivors of Intracranial
Germinomas
Shinya Jinguji（Japan）

O-10

Neuropsychological and QoL Late Effects from the Treatment of CNS Germ Cell
Tumors: the Childrenʼs Oncology Group Experience
Stephen A. Sands（USA）

O-11

Projected Proton Therapy Cognitive Sparing Benefit for CNS Germ Cell Tumor
Patients Adapting a Predictive Model from Intensity Modulated X-ray Therapy
Jonathan B. Farr（USA）

O-12

11:40 - 12:20

Protontherapy for Ventricular Irradiation in Localised Intra-Cranial Germinoma:
The French Experience
Claire Alapetite（France）

Session 3 Diagnostic Radiology/PET
Moderator: Naoki Kagawa（Japan）

12:30 - 13:30

O-13

Hormonal Environment and MR Imaging in Neurohypophyseal Geminomas
Koji Adachi（Japan）

O-14

Value of Advanced MR Imaging for the Diagnosis of Germinoma
Fumiyuki Yamasaki（Japan）

O-15

18F-choline PET/MRI as a Predictive Value of Response to Treatment in Children
with Intracranial Germ Cell Tumours of the Pineal Region
Elwira Szychot（UK）

O-16

Usefulness of 11C-methionine Positron Emission Tomography for Detection ofGerminoma in Central Nervous System
Keisuke Miyake（Japan）

Lunch Time Seminar 1 sponsored by MSD
Moderator: Koichi Ichimura（Japan）
Sounds the Same but Different-The CIMP in Different Tumor Types
Toshikazu Ushijima（Japan）

13:40 - 15:20

Session 4 Basic Science
Moderators: Torsten Pietsch（Germany）, Koji Yoshimoto（Japan）
O-17

β Subunit of Human Chorionic Gonadotropin is Expressed in All Histopathological
Subtypes of Intracranial Germ Cell Tumors
Hirokazu Takami（Japan）

O-18

ARF-BP1 Expression in Primary Intracranial Germ Cell Tumors
Kazuo Washiyama（Japan）

O-19

Activation of the ATM/Chk2 Pathway in Intracranial Germinomas
Koji Yoshimoto（Japan）

O-20

Infiltrating Immune Cells of Intracranial Germinoma and Their Prognostic
SignificanceHirokazu Takami（Japan）

O-21

MicroRNA 372-373 in Cerebrospinal Fluid is Potential Tumor-derived Biomarkers
for CNS Germ Cell Tumors
Keita Terashima（Japan）

O-22

Integrative Epigenome Analysis Discloses Methylation-regulated miRs Involved inTherapy Resistance in GCTs
Tsung-Han Hsieh（Taiwan）

O-23

CNS Germinomas are Characterized by Global Demethylation, Chromosomal
Instability and Mutational Activation of the Kit-, Ras/Raf/Erk- and Akt-pathways
Torsten Pietsch（Germany）

O-24

Genome-wide Methylation Profiles in Primary Intracranial Germ Cell Tumors
Suggest Primordial Germ Cell Origin of Germinoma
Shintaro Fukushima（Japan）

O-25

15:30 - 16:30

Multiply Recurrent Yolk-sac Predominant Suprasellar Mixed Malignant Germ Cell
Tumor Treated with Everolimus: A Case ReportNathan J. Robison（USA）

Special Seminar sponsored by Chugai
Moderator: Keita Terashima（Japan）
SS-1

Development of Personalized Treatment for Patients with Intracranial Germ CellTumors
Ching C. Lau（USA）

SS-2

Molecular Pathogenesis of Intracranial Germ Cell Tumors
Koichi Ichimura（Japan）

Tuesday, April 14
08:30 - 10:15

Session 5 Clinical Topics
Moderators: Jason Fangusaro（USA）, Takamitsu Fujimaki（Japan）

10:20 - 12:25

O-26

Hearing Loss, Tinnitus and Pineal Germinoma: Parinaudʼs Dorsal Midbrain
Syndrome Revisited
Diana Osorio（USA）

O-27

An Update on the Clinical Diagnostic Value of β-hCG and αFP for Intracranial
Germ Cell Tumors
Mingming Hu（China）

O-28

Germinomas can be Diagnosed without Histological Verification
Ryuta Saito（Japan）

O-29

High Diagnostic Value in Placental Alkaline Phosphatase Levels（PLAP）: A New
Marker for Intracranial Germ Cell Tumors
Yasuo Aihara（Japan）

O-30

Treatment Outcomes for Basal Ganglia Germinomas: Experience at a Single
Institute
Yi-Wei Chen（Taiwan）

O-31

Non-germinomatous Germ Cell Tumors with Synchronous Pineal and Suprasellar
Involvement
Hung Ngoc Tran（USA）

O-32

Bifocal Germinomas Treated with whole Ventricular Field of Radiation : To Boostor not to Boost?
Lucie Lafay-Cousin（Canada） ★Presenter replacing the first author

O-33

Evaluation of Surgery in Bifocal Germ Cell Tumors Treated according to the SIOPCNS GCT 96 Protocol
Thomas Czech（Austria）O-34

Initial Presentation and Outcome of Bifocal Germinoma Treated according to SIOPCNS GCT 96
Gabriele Calaminus（Germany）

O-35

CSF Staging for the Germinoma: Does It Matter?
Lucie Lafay-Cousin（Canada）

Session 6 Treatment
sponsored by The Japan Pediatric Brain Tumor Research Fund
Moderators: Eric Bouffet（Canada）, Seung Hoon Lee（Korea）
O-36

A Multi-center Clinical Trial of CNS Germ Cell Tumours in Hong Kong
Matthew Ming Kong Shing（Hong Kong SAR, China）

O-37

The 1st Interim Report of the Multi-institutional, Prospective Phase 2 Study ofRadio-chemotherapy for Primary Intracranial Germ Cell Tumors in Japan
Masao Matsutani（Japan）

O-38

The Childrenʼs Oncology Group Current Approach in Treating Children with
Newly Diagnosed Central Nervous System Localized Germinoma
Soumen Khatua（USA）

12:30 - 13:30

O-39

Primary Chemotherapy and 2nd Look Surgery for CNS NGGCT -single Institution
Experience
Chikako Kiyotani（Japan）

O-40

Evaluation of Neo-adjuvant Therapy（NAT）in Patients with Non-germinomatous
Malignant Germ Cell Tumors
Hideo Nakamura（Japan）

O-41

The Childrenʼs Oncology Group Current Approach to Treat Children with Newly
Diagnosed Central Nervous System Non-germinomatous Germ Cell Tumors
Girish Dhall（USA）

O-42

Relapse and Outcome Patterns of CNS ʻSECRETINGʼ Germ Cell Tumors Treated
without Irradiation: Findings from the Third International CNS GCT Study
Jonathan Lester Finlay（USA）

O-43

The Relapse Pattern and Outcome of Recurrent Central Nervous System Germ Cell
Tumours after Modern Multimodal Treatment
Takaaki Yanagisawa（Japan）

O-44

Experience with a Metronomic Antiangiogenic Combination Therapy in Patientswith Recurrent CNS Non-germinomatous Germ Cell Tumors
Irene Slavc（Austria）

O-45

Preliminary Results of the Prospective Feasibility CNS GCT-4 Consortium Trial inPatients with Refractory/Recurrent CNS Germ Cell Tumors（GCT）
Jonathan Lester Finlay（USA）

O-46

High Dose Chemotherapy with AutoPBSCT for Intracranial Germ Cell Tumor
Relapsing in Young Adulthood
Yoshiki Arakawa（Japan）

O-47

Chemotherapy-Only Strategy for Newly-Diagnosed CNS Germ Cell Tumors in
Low- to Middle-Income Countries（L-MIC）: A Proposal
Jonathan Lester Finlay（USA）

Lunch Time Seminar 2 sponsored by Novocure Ltd.
Moderator: Ryo Nishikawa（Japan）
Tumor Treating Fields（TTFields）-a New Treatment Modality Against SolidTumors
Moshe Giladi（Israel）

14:00

Excursion

18:30 - 21:00

BanquetWednesday, April 15
09:00 - 11:30

Consensus Statement Symposium sponsored by Eisai
Moderators: James Nicholson（UK）, Ryo Nishikawa（Japan）
Symposiasts: James Nicholson（UK）, Matthew Jonathan Murray（UK）,
Ute Bartels（Canada）, Jason Fangusaro（USA）, Thomas Czech（Austria）,
Hidefumi Aoyama（Japan）, Masao Matsutani（Japan）,
Ryo Nishikawa（Japan）
O-48

11:30

International Delphi Consensus for the Management of Intracranial Germ Cell
Tumours
Matthew Jonathan Murray（UK）

Closing Remarks
Ryo Nishikawa（Japan）
Jonathan Lester Finlay（USA）

Posters
P-01

Long-term Outcomes and Late Complication for Central Nervous System
Germinomas
Naoyuki Ohe（Japan）

P-02

Epidemiological Analysis of Paediatric Intracranial Germ Cell Tumour inSingapore
Nwe Mya Soe（Singapore）

P-03

Improvement of Long Term Results with Adjuvant Chemoradiation Therapy forCentral Nervous System Germinoma
Shingo Takano（Japan）

P-04

Treatment of Primary Intracranial Germ Cell Tumors: Single Institution Experienceof 74 Cases without Histologically Confirmed
Chengcheng Guo（China）

P-05

The Treatment Outcome of Intracranial Germinoma in a Single Institution
Etsuko Hattori（Japan）

P-06

Long-term Follow-up of Patients Treated for Intracranial Germinoma and Optimal
Salvage Treatment Strategy for Recurrence
Toshiyuki Amano（Japan）

P-07

Clinical Characteristics of Non-pineal Germ Cell Tumors
Hiroaki Sakamoto（Japan）

P-08

Retrospective Analysis of Local Radiation with Chemotherapy for Germ Cell
Tumors: Pre-Japan Pediatric Brain Tumor Consortium Registry
Kai Yamasaki（Japan）

P-09

Institutional Experience of Treatment Consideration for Primary Intracranial
Germ Cell Tumors
Zhong-Ping Cheng（China）

P-10

Clinical Profiles of 132 Cases of Intracranial Germ Cell Tumors of the iGCTConsortium
Hirokazu Takami（Japan）

P-11

Clinical Course Before Diagnosis in Children with Neurohypophysial Germinoma
Junko Ito（Japan）

P-12

Second-look Surgery for Intracranial Germ Cell Tumors
Hideki Ogiwara（Japan）

P-13

Strategy and Clinical Results for Intracranial Non-germinomatous Germ Cell
Tumors Induced Intensive Chemotherapy
Teruyoshi Kageji（Japan）

P-14

Non-germinomatous Germ Cell Tumors（NGGCT）of the Central Nervous
System in Children: a Single Institutional Experience
Hung Ngoc Tran（USA）

P-15

Intensive Chemotherapy Followed by Reduced Dose Radiation for Intracranial
Non-germinomatous Germ Cell Tumors
Hiroyoshi Watanabe（Japan）

P-16

Neuroendoscopic Management for CNS Germ Cell Tumors
Kazuhiko Kurozumi（Japan）

P-17

Neuro-Surgical Management of CNS Germ Cell Tumour; the Hong KongExperience
Matthew Ming Kong Shing（Hong Kong SAR, China） ★Presenter replacing the first author

P-18

Differences of Histological and Clinical Characteristics in the Teratoma during theTreatment for Intracranial Germ Cell Tumors
Masayuki Kanamori（Japan）

P-19

Are Germinomatous Components Hidden in “Non-germinomatous” Teratomas?
Takamitsu Fujimaki（Japan）

P-20

Hypointensity Changes in T2*-weighted Image（T2*WI）and Susceptibilityweighted Image（SWI）of a Case with Cerebellar and Brain Stem Germinoma
Takashi Sasayama（Japan）

P-21

Relationship between Diagnostic Radiation Dose and Volumetric Changes ofPrimary Intracranial Germinomas before Chemoradiotherapy
Naoki Kagawa（Japan）

P-22

Pitfall of Serum hCG-β Test as a Tumor Marker in Patients with Suprasellar Germ
Cell Tumors
Seiichiro Eguchi（Japan）

P-23

Intracranial Germinomas in a Father and His Son
Kampei Shimizu（Japan）

P-24

Successful Total Excision of an AFP Secreting Pineal Immature Teratoma
Following Radiotherapy: a Case Report
Kazutoshi Yokoyama（Japan）

P-25

A Case of Recurrent Germinoma in the Optic Nerve with Turner Syndrome
Nobuyuki Fukui（Japan）

P-26

Mixed Germ Cell Tumor with Various Histopathological Features at Relapse
Tomoko Waragai（Japan）

P-27

Spinal Mixed Germ Cell Tumor Successfully Treated with Surgery, Radiotherapy,
and Cisplatin-based Chemotherapy: A Case Report
Shota Tanaka（Japan）

P-28

Radiation Induced Glioblastomas in Patients Treated for Germ Cell Tumors
Takahiro Yamamoto（Japan）

P-29

Intracranial Germ Cell Tumors in a Set of Dizygotic Male Twins
Taishi Nakamura（Japan）

P-30

Two Case Reports of Intracranial Germinoma at Unusual Locations: a Case ofMidbrain and of Lateral Ventricle
Hideaki Nagashima（Japan）

P-31

Yolk Sac Tumor of the Cerebellar Hemisphere: Case Report
Masahiro Nonaka（Japan）

P-32

Malignant Transformation of Pure Germinomas: Two Cases Report
Naoki Shinojima（Japan）

P-33

Recurrent Germinomas with Progressive Malignant Transformation: Two Case
Reports
Junichi Yoshimura（Japan）

P-34

A Rapidly Expanding Immature Teratoma Originating from a Neurohypophyseal
Germinoma
Kazuhiro Tanaka（Japan）