Profile of the Mihara Prize 2002 Awardee
As of September 15, 2006
Takaaki Kirino, M.D., Ph.D.
Director General
Research InstituteInternational Medical Center of JapanName
Family Name: Kirino
First Name:
TakaakiSex:
Male
Date of Birth:
July 17, 1946
Place of Birth:
Karatsu, JAPAN
Marital status:
Married with 3 children
Nationality:
Japanese
Present Address: Research InstituteInternational Medical Center of Japan
1-21-1 Toyama, Shinjuku-ku
Tokyo 162-8655, JAPANFAX:+81-3-5273-4526
Phone:+81-3-3202-7181 (International Medical Center)+81-3-5273-6844 (Office)E-mail:tkirino@ri.imcj.go.jp
Education
1965-1967
1967-1972

The University of Tokyo, Faculty of Culture
The University of Tokyo, Faculty of Medicine

Training in Neurosurgery
1972-1973 Junior Resident, Department of Neurosurgery, University of Tokyo Hospital
1978-1979 Senior Resident, Department of Neurosurgery, University of Tokyo Hospital
Research and Professional experience
1979-1980 Staff Neurosurgeon, Dept. of Neurosurgery, Univ. of Tokyo Hospital
1980-1982 Visiting fellow, Lab. of Neuropathology and Neuroanatomical Sciences, NIH,
USA
1982-1986 Assistant Professor, Dept. of Neurosurgery, Teikyo Univ. School of Medicine
1986-1994 Associate Professor, Dept. of Neurosurgery, Teikyo Univ. School of Medicine
1994-2005 Professor, Dept. of Neurosurgery, Faculty of Medicine, the Univ.of Tokyo
1999-2003 Dean, Faculty of Medicine and Graduate School of Medicine, the Univ. ofTokyo2003-2005 Vice-President, The Univ. of Tokyo
2005-present Director General, Research Institute, International Medical Center of Japan
Licenses
1972
1982
1982

M.D. (No. 214954)
Japanese Board of Neurosurgery (No. 1001)
Ph.D. (University of Tokyo, No. No.53565)

BIBLIOGRAPHY

1. Furuya K, Kawahara N, Yamakawa Y, Kishida H, Hachiya NS, Nishijima M,
Kirino T, Kaneko K: Intracerebroventricular delivery of dominant negative prion
protein in a mouse model of iatrogenic Creutzfeldt-Jakob disease after dura grafttransplantation.. Neurosci Lett 402:222-226,2006
2. Hara T, Kawahara N, Tsuboi K, Shibahara J, Ushiku T, Kirino T: Sarcomatoustransformation of clival chordoma after charged-particle radiotherapy. Report oftwo cases.. J Neurosurg 105:136-141,2006
3. Morita A, Shin M, Sekhar LN, Kirino T: Endoscopic microneurosurgery:usefulness and cost-effectiveness in the consecutive experience of 210 patients..
Neurosurgery 58:315-321,2006
4. Yonekura I, Takai K, Asai A, Kawahara N, Kirino T: p53 potentiates hippocampal
neuronal death caused by global ischemia.. J Cereb Blood Flow Metab. 2006
Mar :15;,2006
5. Furuya K, Zhu L, Kawahara N, Abe O, Kirino T: Differences in infarct evolution
between lipopolysaccharide-induced tolerant and nontolerant conditions to focal
cerebral ischemia.. J Neurosurg 103:715-723,2005
6. Hotta S, Morita A, Seichi A, Kirino T: Aberrant vertebral artery course in a case of
Chiari malformation and occipitoatlantal assimilation. Case report.. J Neurosurg
Spine 3:246-248,2005
7. Kamada K, Sawamura Y, Takeuchi F, Kawaguchi H, Kuriki S, Todo T, Morita A,
Masutani Y, Aoki S, Kirino T: Functional identification of the primary motor areaby corticospinal tractography.. Neurosurgery 56:98-109,2005
8. Kamada K, Todo T, Masutani Y, Aoki S, Ino K, Takano T, Kirino T, Kawahara N,
Morita A: Combined use of tractography-integrated functional neuronavigationand direct fiber stimulation.. J Neurosurg 102:664-672,2005
9. Kamada K, Todo T, Morita A, Masutani Y, Aoki S, Ino K, Kawai K, Kirino T:
Functional monitoring for visual pathway using real-time visual evoked potentials

and optic-radiation tractography.. Neurosurgery 57:121-127,2005
10. Kano M, Tsutsumi S, Kawahara N, Wang Y, Mukasa A, Kirino T, Aburatani H: A
meta-clustering analysis indicates distinct pattern alteration between two series ofgene expression profiles for induced ischemic tolerance in rats.. Physiol Genomics
21:274-283,2005
11. Kunii N, Morita A, Yoshikawa G, Kirino T: Subdural hematoma associated with
dural metastasis--case report--.. Neurol Med Chir (Tokyo) 45:519-522,2005
12. Maruyama K, Kamada K, Shin M, Itoh D, Aoki S, Masutani Y, Tago M, Kirino T:
Integration of three-dimensional corticospinal tractography into treatment planningfor gamma knife surgery.. J Neurosurg 102:673-677,2005
13. Maruyama K, Kawahara N, Shin M, Tago M, Kishimoto J, Kurita H, Kawamoto S,
Morita A, Kirino T: The risk of hemorrhage after radiosurgery for cerebral
arteriovenous malformations.. N Engl J Med 352:146-153,2005
14. Maruyama K, Morita A, Shibahara J, Nakazato Y, Kirino T: Multifocal pilocytic
astrocytomas with ependymal differentiation in the bilateral medial temporal lobes:
case report.. Neurol Med Chir (Tokyo) 45:411-414,2005
15. Maruyama K, Shin M, Tago M, Kurita H, Kawamoto S, Morita A, Kirino T:
Gamma knife surgery for arteriovenous malformations involving the corpus
callosum.. J Neurosurg 102 Suppl:49-52,2005
16. Morita A, Fujiwara S, Hashi K, Ohtsu H, Kirino T: Risk of rupture associated with
intact cerebral aneurysms in the Japanese population: a systematic review of theliterature from Japan.. J Neurosurg 102:601-606,2005
17. Morita A, Sora S, Mitsuishi M, Warisawa S, Suruman K, Asai D, Arata J, Baba S,
Takahashi H, Mochizuki R, Kirino T: Microsurgical robotic system for the deep
surgical field: development of a prototype and feasibility studies in animal andcadaveric models.. J Neurosurg 103:320-327,2005
18. Oya S, Kawahara N, Aoki S, Hayashi N, Shibahara J, Izumi M, Kirino T:
Intracranial extracerebral glioneuronal heterotopia. Case report and review of theliterature.. J Neurosurg 102:105-112,2005
19. Saito K, Morita A, Shibahara J, Kirino T: Spinal intramedullary ependymal cyst: acase report and review of the literature.. Acta Neurochir (Wien) 147:443-446,2005
20. Shin M, Kawahara N, Maruyama K, Tago M, Ueki K, Kirino T: Risk ofhemorrhage from an arteriovenous malformation confirmed to have been
obliterated on angiography after stereotactic radiosurgery.. J Neurosurg
102:842-846,2005
21. Shojima M, Oshima M, Takagi K, Torii R, Nagata K, Shirouzu I, Morita A, Kirino

T: Role of the bloodstream impacting force and the local pressure elevation in therupture of cerebral aneurysms.. Stroke 36:1933-1938,2005
22. Yako K, Morita A, Ueki K, Kirino T: Subfrontal schwannoma.. Acta Neurochir(Wien) 147:655-657,2005
23. Yoshino M, Morita A, Shibahara J, Kirino T: Radiation-induced spinal cord
cavernous malformation. Case report.. J Neurosurg 102:101-104,2005
24. Asano S, Mihara B, Kirino T, Sugishita M: Anatomical constraints on visualizationof the human hippocampus using echo-planar imaging.. Neuroradiology
46:535-540,2004
25. Furuya K, Kawahara N, Kawai K, Toyoda T, Maeda K, Kirino T: Proximal
occlusion of the middle cerebral artery in C57Black6 mice: relationship of patencyof the posterior communicating artery, infarct evolution, and animal survival.. J
Neurosurg 100:97-105,2004
26. Furuya K, Kawahara N, Morita A, Momose T, Aoki S, Kirino T: Focal
hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis
in a patient with moyamoya disease. Case report.. J Neurosurg 100:128-132,2004
27. Inoue T, Kawahara N, Shibahara J, Masumoto T, Usami K, Kirino T: Extraduralneurenteric cyst of the cerebellopontine angle. Case report.. J Neurosurg
100:1091-1093,2004
28. Iwamuro H, Morita A, Kawaguchi H, Kirino T: Resolution of spinal epidural
haematoma without surgery in a haemophilic infant.. Acta Neurochir (Wien)
146:1263-1265,2004
29. Kawahara N, Wang Y, Mukasa A, Furuya K, Shimizu T, Hamakubo T, Aburatani
H, Kodama T, Kirino T: Genome-wide gene expression analysis for induced
ischemic tolerance and delayed neuronal death following transient global ischemia
in rats.. J Cereb Blood Flow Metab 24:212-223,2004
30. Kim P, Haisa T, Kawamoto T, Kirino T, Wakai S: Delayed myelopathy induced bychronic compression in the rat spinal cord.. Ann Neurol 55:503-511,2004
31. Maruyama K, Shin M, Kurita H, Kawahara N, Morita A, Kirino T: Proposed
treatment strategy for cavernous sinus meningiomas: a prospective study..
Neurosurgery 55:1068-1075,2004
32. Morita A, Okada Y, Kitano M, Hori T, Taneda M, Kirino T: Development ofhybrid integrated endoscope-holder system for endoscopic microneurosurgery..
Neurosurgery 55:926-931,2004
33. Mukasa A, Ueki K, Ge X, Ishikawa S, Ide T, Fujimaki T, Nishikawa R, Asai A,
Kirino T, Aburatani H: Selective expression of a subset of neuronal genes inoligodendroglioma with chromosome 1p loss.. Brain Pathol 14:34-42,2004
34. Nikaido H, Tsunoda H, Nishimura Y, Kirino T, Tanaka T: Potential role for heatshock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid
hemorrhage.. Circulation 110:1839-1846,2004
35. Shin M, Maruyama K, Kurita H, Kawamoto S, Tago M, Terahara A, Morita A,
Ueki K, Takakura K, Kirino T: Analysis of nidus obliteration rates after gamma
knife surgery for arteriovenous malformations based on long-term follow-up data:
the University of Tokyo experience.. J Neurosurg 101:18-24,2004
36. Shojima M, Oshima M, Takagi K, Torii R, Hayakawa M, Katada K, Morita A,
Kirino T: Magnitude and role of wall shear stress on cerebral aneurysm:
computational fluid dynamic study of 20 middle cerebral artery aneurysms.. Stroke
35:2500-2505,2004
37. Yonekura I, Kawahara N, Nakatomi H, Furuya K, Kirino T: A model of global
cerebral ischemia in C57 BL/6 mice.. J Cereb Blood Flow Metab
24:151-158,2004
38. Asano S, Kawahara N, Kirino T: Intradural spinal seeding of a clival chordoma..
Acta Neurochir (Wien) 145:599-603,2003
39. Hoya K, Asai A, Sasaki T, Nagata K, Kimura K, Kirino T: Expression of myosin
heavy chain isoforms by smooth muscle cells in cerebral arteriovenous
malformations.. Acta Neuropathol (Berl) 105:455-461,2003
40. Ohata K, Saito K, Sekhar LN, Morita A, Kirino T: ["How I do it" no. 6, a case witha giant petroclival meningioma presented with progressive ataxia: how should thiscase be managed?]. No Shinkei Geka 31:1125,2003
41. Watanabe K, Saito N, Taniguchi M, Kirino T, Sasaki T: Analysis of taste
disturbance before and after surgery in patients with vestibular schwannoma.. J
Neurosurg 99:999-1003,2003
42. Asai A, Tanahashi N, Qiu JH, Saito N, Chi S, Kawahara N, Tanaka K, Kirino T:
Selective proteasomal dysfunction in the hippocampal CA1 region after transient
forebrain ischemia.. J Cereb Blood Flow Metab 22:705-710,2002
43. Kawahara N, Kawai K, Toyoda T, Nakatomi H, Furuya K, Kirino T: Cardiac arrest
cerebral ischemia model in mice failed to cause delayed neuronal death in the
hippocampus.. Neurosci Lett 322:91-94,2002
44. Kirino T: Ischemic tolerance.. J Cereb Blood Flow Metab 22:1283-1296,2002
45. Maruyama K, Shin M, Kurita H, Tago M, Kirino T: Stereotactic radiosurgery fordural arteriovenous fistula involving the superior sagittal sinus. Case report.. J
Neurosurg 97:481-483,2002

46. Mochizuki T, Asai A, Saito N, Tanaka S, Katagiri H, Asano T, Nakane M, Tamura
A, Kuchino Y, Kitanaka C, Kirino T: Akt protein kinase inhibits non-apoptotic
programmed cell death induced by ceramide.. J Biol Chem 277:2790-2797,2002
47. Mukasa A, Ueki K, Matsumoto S, Tsutsumi S, Nishikawa R, Fujimaki T, Asai A,
Kirino T, Aburatani H: Distinction in gene expression profiles ofoligodendrogliomas with and without allelic loss of 1p.. Oncogene
21:3961-3968,2002
48. Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A,
Kirino T, Nakafuku M: Regeneration of hippocampal pyramidal neurons after
ischemic brain injury by recruitment of endogenous neural progenitors.. Cell
110:429-441,2002
49. Saito N, Sasaki T, Chikui E, Yuyama R, Kirino T: Anterior transpetrosal approachfor pontine cavernous angioma--case report.. Neurol Med Chir (Tokyo)
42:272-274,2002
50. Shin M, Kawamoto S, Kurita H, Tago M, Sasaki T, Morita A, Ueki K, Kirino T:
Retrospective analysis of a 10-year experience of stereotactic radio surgery forarteriovenous malformations in children and adolescents.. J Neurosurg
97:779-784,2002
51. Shin M, Ueki K, Kurita H, Kirino T: Malignant transformation of a vestibular
schwannoma after gamma knife radiosurgery.. Lancet 360:309-310,2002
52. Shinoura N, Sakurai S, Shibasaki F, Asai A, Kirino T, Hamada H: Co-transductionof Apaf-1 and caspase-9 highly enhances p53-mediated apoptosis in gliomas.. Br J
Cancer 86:587-595,2002
53. Ueki K, Nishikawa R, Nakazato Y, Hirose T, Hirato J, Funada N, Fujimaki T,
Hojo S, Kubo O, Ide T, Usui M, Ochiai C, Ito S, Takahashi H, Mukasa A, Asai A,
Kirino T: Correlation of histology and molecular genetic analysis of 1p, 19q, 10q,
TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors..
Clin Cancer Res 8:196-201,2002
54. Asano S, Ueki K, Suzuki I, Kirino T: Clinical features and medical treatment ofmale prolactinomas.. Acta Neurochir (Wien) 143:465-470,2001
55. Hoya K, Asai A, Sasaki T, Kimura K, Kirino T: Expression of smooth muscle
proteins in cavernous and arteriovenous malformations.. Acta Neuropathol (Berl)
102:257-263,2001
56. Kawai K, Nonaka K, Suzuki H, Kirino T, Tamura A: Differential effects of activity
and climate on onset of subarachnoid hemorrhage.. Neurol Med Chir (Tokyo)
41:229-236,2001

57. Kawai K, Suzuki I, Kurita H, Shin M, Arai N, Kirino T: Failure of low-doseradiosurgery to control temporal lobe epilepsy.. J Neurosurg 95:883-887,2001
58.Kohda T, Asai A, Kuroiwa Y, Kobayashi S, Aisaka K, Nagashima G, Yoshida MC,
Kondo Y, Kagiyama N, Kirino T, Kaneko-Ishino T, Ishino F: Tumour suppressor
activity of human imprinted gene PEG3 in a glioma cell line.. Genes Cells
6:237-247,2001
59. Kurita H, Kawahara N, Asai A, Ueki K, Shin M, Kirino T: Radiation-induced
apoptosis of oligodendrocytes in the adult rat brain.. Neurol Res 23:869-874,2001
60. Kurita H, Shin M, Ueki K, Kawamoto S, Kirino T: Congestive brain oedema
associated with a pial arteriovenous malformation with impaired venous drainage..
Acta Neurochir (Wien) 143:339-342,2001
61. Kurita H, Suzuki I, Shin M, Kawai K, Tago M, Momose T, Kirino T: Successful
radiosurgical treatment of lesional epilepsy of mesial temporal origin.. Minim
Invasive Neurosurg 44:43-46,2001
62. Okamoto K, Shinoura N, Egawa N, Asai A, Kirino T, Shibasaki F, Shitara N:
Adenovirus-mediated transfer of p53 augments hyperthermia-induced apoptosis in
U251 glioma cells.. Int J Radiat Oncol Biol Phys 50:525-531,2001
63. Osada T, Fujimaki T, Takamizawa M, Tsuno NH, Kirino T, Shibata Y: Dendritic
cells activate antitumor immunity for malignant intracranial germ cell tumor: acase report.. Jpn J Clin Oncol 31:403-406,2001
64. Oya S, Fujimaki T, Asai A, Kirino T: Recurrence of infantile supratentorial
ependymoma after 23-year remission following surgical removal and radiation
therapy.. Tumori 87:104-108,2001
65. Oya S, Tsutsumi K, Ueki K, Kirino T: Reinduction of hyponatremia to treat central
pontine myelinolysis.. Neurology 57:1931-1932,2001
66. Shin M, Kurita H, Sasaki T, Kawamoto S, Tago M, Kawahara N, Morita A, Ueki
K, Kirino T: Analysis of treatment outcome after stereotactic radiosurgery forcavernous sinus meningiomas.. J Neurosurg 95:435-439,2001
67. Shinoura N, Furitsu T, Asai A, Kirino T, Hamada H: Co-transduction of p27Kip1
strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG
glioma cells.. Anticancer Res 21:3261-3268,2001
68. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H: Over-expression of APAF-1
and caspase-9 augments radiation-induced apoptosis in U-373MG glioma cells..
Int J Cancer 93:252-261,2001
69. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H: Caspase-9 transduction
overrides the resistance mechanism against p53-mediated apoptosis in U-87MG

glioma cells.. Neurosurgery 49:177-186,2001
70. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H: Co-transduction of Apaf-1
and caspase-9 augments etoposide-induced apoptosis in U-373MG glioma cells..
Jpn J Cancer Res 92:467-474,2001
71. Sora S, Ueki K, Saito N, Kawahara N, Shitara N, Kirino T: Incidence of vonHippel-Lindau disease in hemangioblastoma patients: the University of Tokyo
Hospital experience from 1954-1998.. Acta Neurochir (Wien) 143:893-896,2001
72. Takai K, Nishihara T, Nemoto S, Ueki K, Miyauchi H, Mishima K, Suzuki I,
Kirino T: Multilocular cystic lesion associated with a giant aneurysm.. J
Neurosurg 95:1081,2001
73. Tsutsumi K, Ueki K, Kirino T: Recurrent subarachnoid hemorrhage.. J Neurosurg
94:541-542,2001
74. Tsutsumi K, Ueki K, Morita A, Usui M, Kirino T: Risk of aneurysm recurrence inpatients with clipped cerebral aneurysms: results of long-term follow-up
angiography.. Stroke 32:1191-1194,2001
75. Ueki K, Sasaki T, Ishida T, Kirino T: Spinal tanycytic ependymoma associatedwith neurofibromatosis type 2--case report.. Neurol Med Chir (Tokyo)
41:513-516,2001
76. Fujimaki T, Kirino T: Combined transhorizontal-supracerebellar approach formicrovascular decompression of trigeminal neuralgia.. Br J Neurosurg
14:531-534,2000
77. Fujimaki T, Mishima K, Asai A, Tabuchi K, Kobayashi M, Suzuki I, Kirino T:
Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patientswith malignant germ cell tumor can be used to detect early recurrence and monitor
the response to treatment.. Jpn J Clin Oncol 30:291-294,2000
78. Hoya K, Kirino T: Traumatic trochlear nerve palsy following minor occipital
impact--four case reports.. Neurol Med Chir (Tokyo) 40:358-360,2000
79. Isoo A, Ueki K, Ishida T, Yoshikawa T, Fujimaki T, Suzuki I, Sasaki T, Kirino T:
Langerhans cell histiocytosis limited to the pituitary-hypothalamic axis--two casereports.. Neurol Med Chir (Tokyo) 40:532-535,2000
80. Kirino T: Delayed neuronal death.. Neuropathology 20 Suppl:S95-S97,2000
81. Kurita H, Kawamoto S, Sasaki T, Shin M, Tago M, Terahara A, Ueki K, Kirino T:
Results of radiosurgery for brain stem arteriovenous malformations.. J Neurol
Neurosurg Psychiatry 68:563-570,2000
82. Kurita H, Kawamoto S, Ueki K, Kirino T: Dejerine syndrome caused by ananeurysmal compression.. Arch Neurol 57:1639-1640,2000

83. Kurita H, Segawa H, Shin M, Ueki K, Ichi S, Sasaki T, Tago M, Kirino T:
Radiosurgery of meningeal melanocytoma.. J Neurooncol 46:57-61,2000
84. Kurita H, Shin M, Kirino T: Resolution of migraine with aura caused by an
occipital arteriovenous malformation.. Arch Neurol 57:1219-1220,2000
85. Kurita H, Ueki K, Shin M, Kawamoto S, Sasaki T, Tago M, Kirino T: Headaches
in patients with radiosurgically treated occipital arteriovenous malformations.. J
Neurosurg 93:224-228,2000
86. Maruyama K, Mishima K, Saito N, Fujimaki T, Sasaki T, Kirino T:
Radiation-induced aneurysm and moyamoya vessels presenting with subarachnoid
haemorrhage.. Acta Neurochir (Wien) 142:139-143,2000
87. Matsuno A, Katakami H, Nagashima T, Teramoto A, Osamura RY, Kirino T:
Growth hormone-releasing hormone expression in pituitary somatotroph adenomas,
studied by immunohistochemistry and in situ hybridization using catalyzed signal
amplification system.. Hum Pathol 31:789-794,2000
88. Nakagawa K, Tago M, Terahara A, Aoki Y, Sasaki T, Kurita H, Shin M,
Kawamoto S, Kirino T, Otomo K: A single institutional outcome analysis ofGamma Knife radiosurgery for single or multiple brain metastases.. Clin Neurol
Neurosurg 102:227-232,2000
89. Nakatomi H, Segawa H, Kurata A, Shiokawa Y, Nagata K, Kamiyama H, Ueki K,
Kirino T: Clinicopathological study of intracranial fusiform and dolichoectatic
aneurysms : insight on the mechanism of growth.. Stroke 31:896-900,2000
90. Narita Y, Asai A, Kuchino Y, Kirino T: Actinomycin D and staurosporine, potent
apoptosis inducers in vitro, are potentially effective chemotherapeutic agentsagainstglioblastoma
multiforme..
CancerChemotherPharmacol
45:149-156,2000
91. Nishihara T, Teraoka A, Morita A, Ueki K, Takai K, Kirino T: A transparent
sheath for endoscopic surgery and its application in surgical evacuation of
spontaneous intracerebral hematomas. Technical note.. J Neurosurg
92:1053-1055,2000
92. Qiu JH, Asai A, Chi S, Saito N, Hamada H, Kirino T: Proteasome inhibitors induce
cytochrome c-caspase-3-like protease-mediated apoptosis in cultured corticalneurons.. J Neurosci 20:259-265,2000
93. Saito N, Hayashi N, Okubo T, Takai K, Miyauchi H, Sasaki T, Kirino T: Internal
carotid artery aneurysm visualized during successful endovascular treatment ofcarotid embolism.. AJNR Am J Neuroradiol 21:546-548,2000
94. Saito N, Sasaki T, Okubo T, Kirino T: Pure intracranial vagal neurinoma.. ActaNeurochir (Wien) 142:479-480,2000
95. Shin M, Kurita H, Sasaki T, Tago M, Morita A, Ueki K, Kirino T: Stereotactic
radiosurgery for pituitary adenoma invading the cavernous sinus.. J Neurosurg 93
Suppl 3:2-5,2000
96. Shin M, Kurita H, Tago M, Kirino T: Stereotactic radiosurgery for tentorial duralarteriovenous fistulae draining into the vein of Galen: report of two cases..
Neurosurgery 46:730-733,2000
97. Shin M, Morita A, Asano S, Ueki K, Kirino T: Neuroendoscopic aqueductal stentplacement procedure for isolated fourth ventricle after ventricular shunt placement.
Case report.. J Neurosurg 92:1036-1039,2000
98. Shinoura N, Koike H, Furitu T, Hashimoto M, Asai A, Kirino T, Hamada H:
Adenovirus-mediated transfer of caspase-8 augments cell death in gliomas:
implication for gene therapy.. Hum Gene Ther 11:1123-1137,2000
99. Shinoura N, Muramatsu Y, Asai A, Han S, Horii A, Kirino T, Hamada H: Degreeof apoptosis induced by adenovirus-mediated transduction of p53 or p73alphadepends on the p53 status of glioma cells.. Cancer Lett 160:67-73,2000
100. Shinoura N, Muramatsu Y, Yoshida Y, Asai A, Kirino T, Hamada H:
Adenovirus-mediated transfer of caspase-3 with Fas ligand induces drastic
apoptosis in U-373MG glioma cells.. Exp Cell Res 256:423-433,2000
101. Shinoura N, Ohashi M, Yoshida Y, Kirino T, Asai A, Hashimoto M, Hamada H:
Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas.. Cancer
Gene Ther 7:224-232,2000
102. Shinoura N, Saito K, Yoshida Y, Hashimoto M, Asai A, Kirino T, Hamada H:
Adenovirus-mediated transfer of bax with caspase-8 controlled by myelin basic
protein promoter exerts an enhanced cytotoxic effect in gliomas.. Cancer Gene
Ther 7:739-748,2000
103. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H: Transduction of afiber-mutant adenovirus for the HSVtk gene highly augments the cytopathic effecttowards gliomas.. Jpn J Cancer Res 91:1028-1034,2000
104. Shinoura N, Sakurai S, Asai A, Kirino T, Hamada H: Transduction of Apaf-1 or
caspase-9 induces apoptosis in A-172 cells that are resistant to p53-mediatedapoptosis.. Biochem Biophys Res Commun 272:667-673,2000
105. Shinoura N, Satou R, Yoshida Y, Asai A, Kirino T, Hamada H:
Adenovirus-mediated transfer of Bcl-X(L) protects neuronal cells from
Bax-induced apoptosis.. Exp Cell Res 254:221-231,2000
106. Shinoura N, Yamamoto N, Asai A, Kirino T, Hamada H: Adenovirus-mediatedtransfer of Fas ligand gene augments radiation-induced apoptosis in U-373MG
glioma cells.. Jpn J Cancer Res 91:1044-1050,2000
107. Shinoura N, Yamamoto N, Yoshida Y, Asai A, Kirino T, Hamada H:
Adenovirus-mediated transfer of caspase-8 in combination with superrepressor of
NF-kappaB drastically induced apoptosis in gliomas.. Biochem Biophys Res
Commun 271:544-552,2000
108. Shinoura N, Yamamoto N, Yoshida Y, Fujita T, Saito N, Asai A, Kirino T,
Hamada H: Adenovirus-mediated gene transduction of IkappaB or IkappaB plus
Bax gene drastically enhances tumor necrosis factor (TNF)-induced apoptosis in
human gliomas.. Jpn J Cancer Res 91:41-51,2000
109. Shinoura N, Yoshida Y, Asai A, Kirino T, Hamada H: Adenovirus-mediatedtransfer of p53 and Fas ligand drastically enhances apoptosis in gliomas.. Cancer
Gene Ther 7:732-738,2000
110. Tsutsumi K, Ueki K, Morita A, Kirino T: Risk of rupture from incidental cerebral
aneurysms.. J Neurosurg 93:550-553,2000
111. Yamaoka K, Mishima K, Nagashima Y, Asai A, Sanai Y, Kirino T: Expression of
galectin-1 mRNA correlates with the malignant potential of human gliomas andexpression of antisense galectin-1 inhibits the growth of 9 glioma cells.. J
Neurosci Res 59:722-730,2000
112. Zhu L, Saito N, Abe O, Okubo T, Yamada H, Kawahara N, Asai A, Kirino T:
Changes in the apparent diffusion coefficient of water and T2 relaxation time ingerbil hippocampus after mild ischemia.. Neuroreport 11:3333-3336,2000
113. Asai A, Qiu J, Narita Y, Chi S, Saito N, Shinoura N, Hamada H, Kuchino Y,
Kirino T: High level calcineurin activity predisposes neuronal cells to apoptosis.. J
Biol Chem 274:34450-34458,1999
114. Fujimaki T, Kirino T: Coagulation of the petrosal vein for MVD.. J Neurosurg
90:1148,1999
115. Fujimaki T, Mishima K, Asai A, Suzuki I, Kirino T: Spontaneous regression of aresidual pineal tumor after resection of a cerebellar vermian germinoma.. J
Neurooncol 41:65-70,1999
116. Ide T, Takada K, Qiu JH, Saito N, Kawahara N, Asai A, Kirino T: Ubiquitin stressresponse in postischemic hippocampal neurons under nontolerant and tolerant
conditions.. J Cereb Blood Flow Metab 19:750-756,1999
117. Kawahara N, Kume H, Ueki K, Mishima K, Sasaki T, Kirino T: VHL gene
inactivation in an endolymphatic sac tumor associated with von Hippel-Lindau
disease.. Neurology 53:208-210,1999

118. Kawahara N, Mishima K, Higashiyama S, Taniguchi N, Tamura A, Kirino T: Thegene for heparin-binding epidermal growth factor-like growth factor isstress-inducible: its role in cerebral ischemia.. J Cereb Blood Flow Metab
19:307-320,1999
119. Kim P, Yoshimoto Y, Nakaguchi H, Mori T, Asai A, Sasaki T, Kirino T,
Nonomura Y: Increased sarcolemmal permeability in the cerebral artery during
chronic spasm: an assessment using DNA-binding dyes and detection of apoptosis..
J Cereb Blood Flow Metab 19:889-897,1999
120. Kirino T: [Molecular biology and cerebrovascular diseases]. No Shinkei Geka
27:111-118,1999
121. Kurita H, Kawamoto S, Kirino T: Radiosurgically treated acromegaly.. J Neurol
Neurosurg Psychiatry 66:244,1999
122. Kurita H, Kawamoto S, Sasaki T, Shin M, Ueki K, Momose T, Terahara A, Kirino
T: Relief of hemiballism from a basal ganglia arteriovenous malformation afterradiosurgery.. Neurology 52:188-190,1999
123. Kurita H, Kirino T: A longitudinal study of patients with venous malformations..
Neurology 52:1109-1110,1999
124. Kurita H, Sasaki T, Tago M, Kaneko Y, Kirino T: Successful radiosurgicaltreatment of arteriovenous malformation accompanied by venous malformation..
AJNR Am J Neuroradiol 20:482-485,1999
125. Kurita H, Segawa H, Ueki K, Kirino T: A sneezer's headache.. Neurology
53:654-655,1999
126. Matsuno A, Sasaki T, Kirino T: Plurihormonal pituitary tumor.. J Neurosurg
90:608-609,1999
127. Nakaguchi H, Fujimaki T, Matsuno A, Matsuura R, Asai A, Suzuki I, Sasaki T,
Kirino T: Postoperative residual tumor growth of meningioma can be predicted by
MIB-1 immunohistochemistry.. Cancer 85:2249-2254,1999
128. Nakaguchi H, Fujimaki T, Ueki K, Takahashi M, Yoshida H, Kirino T: Snowboard
head injury: prospective study in Chino, Nagano, for two seasons from 1995 to
1997.. J Trauma 46:1066-1069,1999
129. Nukui H, Abe H, Kirino T, Ogawa A, Katayama Y: Neurosurgeons request better
relationships in the Japanese Organ Transplantation System. Organ Transplantation
and Brain Death Investigation Committee of the Japan Neurosurgical Society..
Transplant Proc 31:1950,1999
130. Sasaki T, Sasaki T, Okamoto K, Ishida T, Kirino T: Cavernous angioma of theinternal acoustic meatus--case report.. Neurol Med Chir (Tokyo) 39:847-851,1999

131. Shinoura N, Muramatsu Y, Nishimura M, Yoshida Y, Saito A, Yokoyama T,
Furukawa T, Horii A, Hashimoto M, Asai A, Kirino T, Hamada H:
Adenovirus-mediated transfer of p33ING1 with p53 drastically augments apoptosis
in gliomas.. Cancer Res 59:5521-5528,1999
132. Shinoura N, Yoshida Y, Asai A, Kirino T, Hamada H: Relative level of expressionof Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by
the overexpression of Bax.. Oncogene 18:5703-5713,1999
133. Shinoura N, Yoshida Y, Nishimura M, Muramatsu Y, Asai A, Kirino T, Hamada
H: Expression level of Bcl-2 determines anti- or proapoptotic function.. Cancer
Res 59:4119-4128,1999
134. Shinoura N, Yoshida Y, Tsunoda R, Ohashi M, Zhang W, Asai A, Kirino T,
Hamada H: Highly augmented cytopathic effect of a fiber-mutant E1B-defective
adenovirus for gene therapy of gliomas.. Cancer Res 59:3411-3416,1999
135. Tsutsumi K, Ohno H, Okada Y, Fujimaki T, Kirino T: Fenestrated oculomotor
nerve caused by meningioma around the cavernous sinus: a surgical pitfall intumor removal: case report.. Neurosurgery 44:395-396,1999
136. Tsutsumi K, Ueki K, Usui M, Kwak S, Kirino T: Risk of subarachnoid hemorrhage
after surgical treatment of unruptured cerebral aneurysms.. Stroke
30:1181-1184,1999
137. Ueki K, Wen-Bin C, Narita Y, Asai A, Kirino T: Tight association of loss of
merlin expression with loss of heterozygosity at chromosome 22q in sporadic
meningiomas.. Cancer Res 59:5995-5998,1999
138. Watanabe T, Nagamatsu S, Matsushima S, Kirino T, Uchimura H: Colocalizationof GLUT3 and choline acetyltransferase immunoreactivity in the rat retina..
Biochem Biophys Res Commun 256:505-511,1999
139. Watanabe T, Nagamatsu S, Matsushima S, Kondo K, Motobu H, Hirosawa K,
Mabuchi K, Kirino T, Uchimura H: Developmental expression of GLUT2 in the
rat retina.. Cell Tissue Res 298:217-223,1999
140. Wenbin C, Asai A, Teramoto A, Sanno N, Kirino T: Mutations of the MEN1
tumor suppressor gene in sporadic pituitary tumors.. Cancer Lett 142:43-47,1999
141. Fujimaki T, Sasaki T, Kirino T: Microvascular decompression.. J Neurosurg
88:617-618,1998
142. Kawahara N, Ide T, Saito N, Kawai K, Kirino T: Propentofylline potentiates
induced ischemic tolerance in gerbil hippocampal neurons via adenosine receptor..
J Cereb Blood Flow Metab 18:472-475,1998
143. Kawahara N, Sasaki T, Nibu K, Sugasawa M, Ichimura K, Nakatsuka T, Yamada

A, Kirino T: Dumbbell type jugular foramen meningioma extending both into theposterior cranial fossa and into the parapharyngeal space: report of 2 cases with
vascular reconstruction.. Acta Neurochir (Wien) 140:323-330,1998
144. Kawai K, Nakagomi T, Kirino T, Tamura A, Kawai N: Preconditioning in vivo
ischemia inhibits anoxic long-term potentiation and functionally protects CA1
neurons in the gerbil.. J Cereb Blood Flow Metab 18:288-296,1998
145. Kawai K, Narita Y, Nagai A, Nakagomi T, Kobayashi K, Kirino T, Tamura A:
Traumatic chiasmal syndrome presenting with bitemporal hemianopsia.. J Trauma
44:224-229,1998
146. Kim P, Wakai S, Matsuo S, Moriyama T, Kirino T: Bisegmental cervical interbody
fusion using hydroxyapatite implants: surgical results and long-term observation in
70 cases.. J Neurosurg 88:21-27,1998
147. Kurita H, Kawamoto S, Suzuki I, Sasaki T, Tago M, Terahara A, Kirino T: Controlof epilepsy associated with cerebral arteriovenous malformations afterradiosurgery.. J Neurol Neurosurg Psychiatry 65:648-655,1998
148. Kurita H, Sasaki T, Suzuki I, Kirino T: Basal ganglia arteriovenous malformation
presenting as "writer's cramp".. Childs Nerv Syst 14:285-287,1998
149. Mishima K, Higashiyama S, Asai A, Yamaoka K, Nagashima Y, Taniguchi N,
Kitanaka C, Kirino T, Kuchino Y: Heparin-binding epidermal growth factor-likegrowth factor stimulates mitogenic signaling and is highly expressed in humanmalignant gliomas.. Acta Neuropathol (Berl) 96:322-328,1998
150. Mishima K, Sasaki T, Ojima T, Mukasa A, Kirino T: Multilobular cavernous
malformation: report of two cases.. Acta Neurochir (Wien) 140:20-25,1998
151. Morikawa E, Mori H, Kiyama Y, Mishina M, Asano T, Kirino T: Attenuation of
focal ischemic brain injury in mice deficient in the epsilon1 (NR2A) subunit of
NMDA receptor.. J Neurosci 18:9727-9732,1998
152. Nishiyama M, Okamoto H, Watanabe T, Hori T, Sasaki T, Kirino T, Shimizu T:
Endothelium is required for 12-hydroperoxyeicosatetraenoic acid-induced
vasoconstriction.. Eur J Pharmacol 341:57-63,1998
153. Sano T, Asai A, Mishima K, Fujimaki T, Kirino T: Telomerase activity in 144
brain tumours.. Br J Cancer 77:1633-1637,1998
154. Sasaki T, Kurita H, Saito I, Kawamoto S, Nemoto S, Terahara A, Kirino T,
Takakura K: Arteriovenous malformations in the basal ganglia and thalamus:
management and results in 101 cases.. J Neurosurg 88:285-292,1998
155. Shinoura N, Ohashi M, Yoshida Y, Asai A, Kirino T, Saito I, Hamada H:
Construction, propagation, and titer estimation of recombinant adenovirusescarrying proapoptotic genes.. Hum Gene Ther 9:2683-2689,1998
156. Shinoura N, Yoshida Y, Sadata A, Hanada KI, Yamamoto S, Kirino T, Asai A,
Hamada H: Apoptosis by retrovirus- and adenovirus-mediated gene transfer of Fas
ligand to glioma cells: implications for gene therapy.. Hum Gene Ther
9:1983-1993,1998
157. Todo T, Kondo T, Kirino T, Asai A, Adams EF, Nakamura S, Ikeda K, Kurokawa
T: Expression and growth stimulatory effect of fibroblast growth factor 9 in humanbrain tumors.. Neurosurgery 43:337-346,1998
158. Todo T, Kondo T, Nakamura S, Kirino T, Kurokawa T, Ikeda K: Neuronal
localization of fibroblast growth factor-9 immunoreactivity in human and rat brain..
Brain Res 783:179-187,1998
159. Tsutsumi K, Ueki K, Usui M, Kwak S, Kirino T: Risk of recurrent subarachnoid
hemorrhage after complete obliteration of cerebral aneurysms.. Stroke
29:2511-2513,1998
160. Yuyama R, Mishima K, Fujimaki T, Suzuki I, Sasaki T, Ueno H, Shibata Y, Kirino
T: [Clinical experience of autologous blood transfusion and fibrin glue inneurosurgery]. No Shinkei Geka 26:685-690,1998
161. Fujimaki T, Matsuno A, Sasaki T, Toyoda T, Matsuura R, Ogai M, Kitanaka C,
Asai A, Matsutani M, Kirino T: Proliferative activity of central neurocytoma:measurement of tumor volume doubling time, MIB-1 staining index andbromodeoxyuridine labeling index.. J Neurooncol 32:103-109,1997
162. Kurita H, Sasaki T, Kawamoto S, Taniguchi M, Terahara A, Tago M, Kirino T:
Role of radiosurgery in the management of cavernous sinus meningiomas.. Acta
Neurol Scand 96:297-304,1997
163. Maeda K, Kurita H, Nakamura T, Usui M, Tsutsumi K, Morimoto T, Kirino T:
Occurrence of severe vasospasm following intraventricular hemorrhage from anarteriovenous malformation. Report of two cases.. J Neurosurg 87:436-439,1997
164. Matsuno A, Sasaki T, Nagashima T, Matsuura R, Tanaka H, Hirakawa M,
Murakami M, Kirino T: Immunohistochemical examination of proliferative
potentials and the expression of cell cycle-related proteins of intracranial
chordomas.. Hum Pathol 28:714-719,1997
165. Mishima K, Asai A, Kadomatsu K, Ino Y, Nomura K, Narita Y, Muramatsu T,
Kirino T: Increased expression of midkine during the progression of humanastrocytomas.. Neurosci Lett 233:29-32,1997
166. Nakagomi T, Kanemitsu H, Takagi K, Morikawa E, Kirino T, Tamura A: Effect of
L-arginine and NG-nitro-L-arginine on delayed neuronal death in the gerbil

hippocampus.. Neurol Res 19:426-430,1997
167. Nakaguchi H, Sasaki T, Kirino T, Okubo T, Hayashi N: [Efficacy of the
TURBO-fluid attenuated inversion recovery spin echo sequence of MRI as apreoperative neuroradiological examination]. No Shinkei Geka 25:599-606,1997
168. Ohwaki K, Tanishima T, Yoshimasu N, Hojo S, Fujimaki T, Kirino T: [Rapidly
enlarging supratentorial ependymoma in a child presenting initially with a small
calcified lesion: case report]. No Shinkei Geka 25:713-718,1997
169. Sasaki T, Matsuno A, Inoh Y, Asai A, Kirino T: A rare case of hamartoma in thelateral ventricle: case report.. Surg Neurol 47:23-27,1997
170. Tsutsumi K, Maeda K, Iijima A, Usui M, Okada Y, Kirino T: The relationship ofpreoperative magnetic resonance imaging findings and closed system drainage inthe recurrence of chronic subdural hematoma.. J Neurosurg 87:870-875,1997
171. Fujimaki T, Hoya K, Sasaki T, Kirino T: Recurrent trigeminal neuralgia caused byan inserted prosthesis: report of two cases.. Acta Neurochir (Wien)
138:1307-1309,1996
172. Fujimaki T, Price JE, Fan D, Bucana CD, Itoh K, Kirino T, Fidler IJ: Selective
growth of human melanoma cells in the brain parenchyma of nude mice..
Melanoma Res 6:363-371,1996
173. Furuya K, Sasaki T, Suzuki I, Kim P, Saito N, Kirino T: Intramedullary
angiographically occult vascular malformations of the spinal cord.. Neurosurgery
39:1123-1130,1996
174. Ide T, Morikawa E, Kirino T: An immunosuppressant, FK506, protects
hippocampal neurons from forebrain ischemia in the mongolian gerbil.. Neurosci
Lett 204:157-160,1996
175. Kim P, Yoshimoto Y, Iino M, Tomio S, Kirino T, Nonomura Y: Impaired calcium
regulation of smooth muscle during chronic vasospasm following subarachnoid
hemorrhage.. J Cereb Blood Flow Metab 16:334-341,1996
176. Kirino T, Nakagomi T, Kanemitsu H, Tamura A: Ischemic tolerance.. Adv Neurol
71:505-511,1996
177. Kurita H, Sasaki T, Kawamoto S, Taniguchi M, Kitanaka C, Nakaguchi H, Kirino
T: Chronic encapsulated expanding hematoma in association with gamma knife
stereotactic radiosurgery for a cerebral arteriovenous malformation. Case report.. J
Neurosurg 84:874-878,1996
178. Matsuno A, Fujimaki T, Sasaki T, Nagashima T, Ide T, Asai A, Matsuura R,
Utsunomiya H, Kirino T: Clinical and histopathological analysis of proliferative
potentials of recurrent and non-recurrent meningiomas.. Acta Neuropathol (Berl)

91:504-510,1996
179. Matsuno A, Nagashima T, Matsuura R, Tanaka H, Hirakawa M, Murakami M,
Tamura A, Kirino T: Correlation between MIB-1 staining index and theimmunoreactivity of p53 protein in recurrent and non-recurrent meningiomas.. Am
J Clin Pathol 106:776-781,1996
180. Matsuno A, Sasaki T, Mochizuki T, Fujimaki T, Sanno N, Osamura Y, Teramoto
A, Kirino T: A case of pituitary somatotroph adenoma with concomitant secretionof growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma
derived from primordial stem cell, studied by immunohistochemistry, in situ
hybridization, and cell culture.. Acta Neurochir (Wien) 138:1002-1007,1996
181. Mishima K, Asai A, Sugiyama A, Miyagi Y, Kitanaka C, Kagaya S, Kirino T,
Kuchino Y: Increased expression of schwannoma-derived growth factor (SDGF)
mRNA in rat tumor cells: involvement of SDGF in the growth promotion of rat
gliomas.. Int J Cancer 66:352-357,1996
182. Mishima K, Higashiyama S, Nagashima Y, Miyagi Y, Tamura A, Kawahara N,
Taniguchi N, Asai A, Kuchino Y, Kirino T: Regional distribution of
heparin-binding epidermal growth factor-like growth factor mRNA and protein in
adult rat forebrain.. Neurosci Lett 213:153-156,1996
183. Morikawa E, Zhang SM, Seko Y, Toyoda T, Kirino T: Treatment of focal cerebral
ischemia with synthetic oligopeptide corresponding to lectin domain of selectin..
Stroke 27:951-955,1996
184. Morimoto T, Ide T, Ihara Y, Tamura A, Kirino T: Transient ischemia depletes freeubiquitin in the gerbil hippocampal CA1 neurons.. Am J Pathol 148:249-257,1996
185. Nagata K, Sasaki T, Mori T, Nikaido H, Kobayashi E, Kim P, Kirino T: Cisternal
talc injection in dog can induce delayed and prolonged arterial constriction
resembling cerebral vasospasm morphologically and pharmacologically.. Surg
Neurol 45:442-447,1996
186. Nakagomi T, Asai A, Kanemitsu H, Narita K, Kuchino Y, Tamura A, Kirino T:
Up-regulation of c-myc gene expression following focal ischemia in the rat brain..
Neurol Res 18:559-563,1996
187. Nakaguchi H, Suzuki I, Taniguchi M, Kirino T, Ichimura K, Nibu K, Yamada A,
Kajikawa A: [A case of middle cranial fossa meningioma extending into theinfratemporal fossa: an approach to the pterygoid extension of the sphenoid sinus
via the infratemporal fossa]. No Shinkei Geka 24:643-648,1996
188. Nakatomi H, Sasaki T, Kawamoto S, Fujimaki T, Furuya K, Kirino T: Primary
cavernous sinus malignant lymphoma treated by gamma knife radiosurgery: case

report and review of the literature.. Surg Neurol 46:272-278,1996
189. Nishihara T, Hara T, Suzuki I, Kirino T, Yamakawa K: Third ventriculostomy for
symptomatic syringomyelia using flexible endoscope: case report.. Minim
Invasive Neurosurg 39:130-132,1996
190. Chang HS, Kirino T: Quantification of operative benefit for unruptured cerebral
aneurysms: a theoretical approach.. J Neurosurg 83:413-420,1995
191. Furuya K, Sasaki T, Saito N, Atsuchi M, Kirino T: Primary large choroid plexus
papillomas in the cerebellopontine angle: radiological manifestations and surgicalmanagement.. Acta Neurochir (Wien) 135:144-149,1995
192. Furuya K, Sasaki T, Yoshimoto Y, Okada Y, Fujimaki T, Kirino T: Histologicallyverified cerebral aneurysm formation secondary to embolism from cardiac
myxoma. Case report.. J Neurosurg 83:170-173,1995
193. Kurita H, Shiokawa Y, Segawa H, Kirino T: Delayed parent artery narrowing
occurring months after aneurysm surgery: a complication after aneurysm
surgery--technical case report.. Neurosurgery 36:1225-1229,1995
194. Matsuno A, Ohsugi Y, Utsunomiya H, Takekoshi S, Sanno N, Osamura RY,
Watanabe K, Teramoto A, Kirino T: Changes in the ultrastructural distribution ofprolactin and growth hormone mRNAs in pituitary cells of female rats after
estrogen and bromocriptine treatment, studied using in situ hybridization withbiotinylated oligonucleotide probes.. Histochem Cell Biol 104:37-45,1995
195. Matsuno A, Sasaki T, Saito N, Mochizuki T, Fujimaki T, Kirino T, Takakura K:
Transcavernous surgery; an effective treatment for pituitary macroadenomas.. Eur
J Endocrinol 133:156-165,1995
196. Matsuno A, Teramoto A, Takekoshi S, Sanno N, Osamura RY, Kirino T:
Expression of plurihormonal mRNAs in somatotrophic adenomas detected using anonisotopic in situ hybridization method: comparison with lactotrophic adenomas..
Hum Pathol 26:272-279,1995
197. Matsuno A, Teramoto A, Takekoshi S, Sanno N, Osamura RY, Kirino T: HGH,
PRL, and ACTH Gene Expression in Clinically Nonfunctioning Adenomas
Detected with Nonisotopic In Situ Hybridization Method.. Endocr Pathol
6:13-20,1995
198. Mizutani T, Aruga T, Kirino T, Miki Y, Saito I, Tsuchida T: Recurrent
subarachnoid hemorrhage from untreated ruptured vertebrobasilar dissecting
aneurysms.. Neurosurgery 36:905-911,1995
199. Okada M, Tamura A, Urae A, Nakagomi T, Kirino T, Mine K, Fujiwara M:
Long-term spatial cognitive impairment following middle cerebral artery occlusion

in rats. A behavioral study.. J Cereb Blood Flow Metab 15:505-512,1995
200. Sasaki T, Hoya K, Kinone K, Kirino T: Postsurgical development of duralarteriovenous malformations after transpetrosal and transtentorial operations: casereport.. Neurosurgery 37:820-824,1995
201. Sasaki T, Taniguchi M, Suzuki I, Kirino T: En bloc petrosectomy using a Gigli
saw for petroclival lesions. Technical note.. J Neurosurg 83:559-560,1995
202. Toyoda T, Matsutani M, Kawai K, Iwasaki Y, Kirino T: Astrocytomas arising in
the tectal region of the mesencephalon: report of two cases.. Radiat Med
13:315-317,1995
203. Yoshimoto Y, Kim P, Sasaki T, Kirino T, Takakura K: Functional changes incultured strips of canine cerebral arteries after prolonged exposure tooxyhemoglobin.. J Neurosurg 83:867-874,1995
204. Fujimaki T, Matsutani M, Funada N, Kirino T, Takakura K, Nakamura O, Tamura
A, Sano K: CT and MRI features of intracranial germ cell tumors.. J Neurooncol
19:217-226,1994
205. Kanemitsu H, Kirino T, Nakagomi T, Tsujita Y, Iwamoto T, Tomich JM, Tamura
A: Key of induced tolerance to ischaemia in gerbil hippocampal CA1 is not attranscriptional level of hsp70 gene: in situ hybridization of hsp70 mRNA.. Neurol
Res 16:209-212,1994
206. Kirino T: [Clinical significance of delayed nerve cell death]. Nippon Naika
Gakkai Zasshi 83:828-833,1994
207. Kirino T: [Cerebral ischemia and neuronal death]. No To Hattatsu
26:130-135,1994
208. Matsuno A, Ohsugi Y, Utsunomiya H, Takekoshi S, Osamura RY, Watanabe K,
Teramoto A, Kirino T: Ultrastructural distribution of growth hormone andprolactin mRNAs in normal rat pituitary cells: a comparison between
preembedding and postembedding methods.. Histochemistry 102:265-270,1994
209. Matsuno A, Teramoto A, Takekoshi S, Utsunomiya H, Ohsugi Y, Kishikawa S,
Osamura RY, Kirino T, Lloyd RV: Application of biotinylated oligonucleotide
probes to the detection of pituitary hormone mRNA using northern blot analysis, insitu hybridization at the light- and electron-microscope levels.. Histochem J
26:771-777,1994
210.Matsuno A, Teramoto A, Yamada S, Kitanaka S, Tanaka T, Sanno N, Osamura RY,
Kirino T: Gigantism in sibling unrelated to multiple endocrine neoplasia: casereport.. Neurosurgery 35:952-955,1994
211. Mori T, Nagata K, Ishida T, Nikaido H, Kobayashi E, Sasaki T, Ohami H, Kirino

T: Sequential morphological changes of the constrictive basilar artery in a canine
model of experimental cerebral vasospasm by talc injection.. J Vet Med Sci
56:535-540,1994
212. Gotoh O, Tamura A, Kirino T, Sano K, Nihei H, Manaka S: [Vasospasm and its
outcome after early surgery for ruptured cerebral aneurysms: relationship with theclinical grade based on the Glasgow Coma Scale]. No Shinkei Geka
21:221-226,1993
213. Ishiguro H, Inuzuka T, Fujita N, Sato S, Nakano R, Tamura A, Kirino T, Miyatake
T: Expression of the large myelin-associated glycoprotein isoform in rat
oligodendrocytes around cerebral infarcts.. Mol Chem Neuropathol
20:173-179,1993
214. Kirino T: Presynaptic terminals in hippocampal gliosis following transientischemia in the Mongolian gerbil.. Prog Brain Res 96:261-270,1993
215. Mori T, Nagata K, Ishida T, Sasaki T, Nirei H, Hamada K, Ohami H, Kirino T:
FK-506: a new immunosuppressive agent, failed to reduce cerebral vasospasm
after experimental subarachnoid hemorrhage.. J Vet Med Sci 55:581-586,1993
216. Nagata K, Sasaki T, Iwama J, Mori T, Iwamoto S, Nirei H, Hamada K, Kirino T:
Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in acanine two-hemorrhage model.. J Neurosurg 79:710-715,1993
217. Nakagomi T, Kirino T, Kanemitsu H, Tsujita Y, Tamura A: Early recovery ofprotein synthesis following ischemia in hippocampal neurons with induced
tolerance in the gerbil.. Acta Neuropathol (Berl) 86:10-15,1993
218. Kirino T: [Ischemia and neuronal cell death]. Kokyu To Junkan 40:323-331,1992
219. Kirino T, Robinson HP, Miwa A, Tamura A, Kawai N: Disturbance of membrane
function preceding ischemic delayed neuronal death in the gerbil hippocampus.. J
Cereb Blood Flow Metab 12:408-417,1992
220. Nishiyama M, Okamoto H, Watanabe T, Hori T, Hada T, Ueda N, Yamamoto S,
Tsukamoto H, Watanabe K, Kirino T: Localization of arachidonate
12-lipoxygenase in canine brain tissues.. J Neurochem 58:1395-1400,1992
221. Tsubokawa H, Oguro K, Robinson HP, Masuzawa T, Kirino T, Kawai N:
Abnormal Ca2+ homeostasis before cell death revealed by whole cell recording ofischemic CA1 hippocampal neurons.. Neuroscience 49:807-817,1992
222. Kirino T, Tsujita Y, Tamura A: Induced tolerance to ischemia in gerbil
hippocampal neurons.. J Cereb Blood Flow Metab 11:299-307,1991
223. Tamura A, Tahira Y, Nagashima H, Kirino T, Gotoh O, Hojo S, Sano K: Thalamic
atrophy following cerebral infarction in the territory of the middle cerebral artery..

Stroke 22:615-618,1991
224. Yamamoto M, Tamura A, Kirino T, Shimizu-Sasamata M, Sano K: Effects ofthyrotropin-releasing hormone on behavioral disturbances in middle cerebral
artery-occluded rats.. Eur J Pharmacol 197:117-123,1991
225. Yoshida S, Kirino T, Tamura A, Basugi N, Sano K: Lithium ion does not protect
brain against transient ischemia in gerbils.. Stroke 22:84-89,1991
226. Fujie W, Kirino T, Tomukai N, Iwasawa T, Tamura A: Progressive shrinkage ofthe thalamus following middle cerebral artery occlusion in rats.. Stroke
21:1485-1488,1990
227. Inuzuka T, Tamura A, Sato S, Kirino T, Toyoshima I, Miyatake T: Suppressive
effect of E-64c on ischemic degradation of cerebral proteins following occlusion of
the middle cerebral artery in rats.. Brain Res 526:177-179,1990
228. Inuzuka T, Tamura A, Sato S, Kirino T, Yanagisawa K, Toyoshima I, Miyatake T:
Changes in the concentrations of cerebral proteins following occlusion of the
middle cerebral artery in rats.. Stroke 21:917-922,1990
229. Kirino T, Tamura A, Sano K: Chronic maintenance of presynaptic terminals ingliotic hippocampus following ischemia.. Brain Res 510:17-25,1990
230. Sano K, Kirino T: Ammon's horn sclerosis: its pathogenesis and clinicalsignificance.. Tohoku J Exp Med 161 Suppl:273-295,1990
231. Tamura A, Kirino T, Sano K, Takagi K, Oka H: Atrophy of the ipsilateralsubstantia nigra following middle cerebral artery occlusion in the rat.. Brain Res
510:154-157,1990
232. Kanemitsu H, Tamura A, Kirino T, Oka H, Sano K, Iwamoto T, Yoshiura M,
Iriyama K: Allopurinol inhibits uric acid accumulation in the rat brain following
focal cerebral ischemia.. Brain Res 499:367-370,1989
233. Kirino T: [Neuronal degeneration and glutamate]. Rinsho Shinkeigaku
29:1522-1525,1989
234. Nakagomi T, Sasaki T, Kirino T, Tamura A, Noguchi M, Saito I, Takakura K:
Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in
the gerbil hippocampus.. Stroke 20:925-929,1989
235. Yamamoto M, Tamura A, Kirino T, Hirakawa M, Shimizu M, Sano K: Effects of a
new thyrotropin-releasing hormone analogue administered in rats 1 week after
middle cerebral artery occlusion.. Stroke 20:1089-1091,1989
236. Yamamoto M, Tamura A, Kirino T, Shimizu M, Sano K: Effects of a new
thyrotropin-releasing hormone derivative on behavioral changes after focal
cerebral ischemia in rats.. Stroke 20:362-366,1989

237. Kanemitsu H, Tamura A, Kirino T, Karasawa S, Sano K, Iwamoto T, Yoshiura M,
Iriyama K: Xanthine and uric acid levels in rat brain following focal ischemia.. J
Neurochem 51:1882-1885,1988
238. Sasaki T, Nakagomi T, Kirino T, Tamura A, Noguchi M, Saito I, Takakura K:
Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal
CA1 sector.. Stroke 19:1399-1403,1988
239. Yamamoto M, Tamura A, Kirino T, Shimizu M, Sano K: Behavioral changes after
focal cerebral ischemia by left middle cerebral artery occlusion in rats.. Brain Res
452:323-328,1988
240. Kamano S, Kirino T, Mizuno S: Intrameatal aneurysm.. Neurochirurgia (Stuttg)
29:28-30,1986
241. Kirino T, Tamura A, Sano K: A reversible type of neuronal injury following
ischemia in the gerbil hippocampus.. Stroke 17:455-459,1986
242. Kirino T, Tamura A, Tomukai N, Sano K: [Treatable ischemic neuronal damage in
the gerbil hippocampus]. No To Shinkei 38:1157-1163,1986
243. Kirino T, Tamura A, Sano K: Selective vulnerability of the hippocampus toischemia--reversible and irreversible types of ischemic cell damage.. Prog Brain
Res 63:39-58,1985
244. Akishige S, Ishikawa I, Miyakawa E, Yamaguchi S, Lee J, Kirino T, Matsue I: [Aclinical study of the relation between fusion patterns of the roots and periodontal
disease in the upper molars]. Nippon Shishubyo Gakkai Kaishi 26:339-347,1984
245. Kirino T, Sano K: Selective vulnerability in the gerbil hippocampus following
transient ischemia.. Acta Neuropathol (Berl) 62:201-208,1984
246. Kirino T, Sano K: Fine structural nature of delayed neuronal death following
ischemia in the gerbil hippocampus.. Acta Neuropathol (Berl) 62:209-218,1984
247. Kirino T, Tamura A, Sano K: Delayed neuronal death in the rat hippocampus
following transient forebrain ischemia.. Acta Neuropathol (Berl) 64:139-147,1984
248. Kirino T, Brightman MW, Oertel WH, Schmechel DE, Marangos PJ:
Neuron-specific enolase as an index of neuronal regeneration and reinnervation.. J
Neurosci 3:915-923,1983
249. Suzuki R, Yamaguchi T, Kirino T, Orzi F, Klatzo I: The effects of 5-minuteischemia in Mongolian gerbils: I. Blood-brain barrier, cerebral blood flow, andlocal cerebral glucose utilization changes.. Acta Neuropathol (Berl)
60:207-216,1983
250. Kirino T: Delayed neuronal death in the gerbil hippocampus following ischemia..
Brain Res 239:57-69,1982

251. Sasaki T, Wakai S, Asano T, Watanabe T, Kirino T, Sano K: The effect of a lipidhydroperoxide of arachidonic acid on the canine basilar artery. An experimental
study on cerebral vasospasm.. J Neurosurg 54:357-365,1981
252. Hirokawa N, Kirino T: An ultrastructural study of nerve and glial cells by
freeze-substitution.. J Neurocytol 9:243-254,1980
253. Kirino T: [Degeneration and repair of the brain after cerebral infarction--changes
in the neuropil of the contralateral hemisphere in Mongolian gerbils (author'stransl)]. No To Shinkei 32:1071-1079,1980
254. Kirino T, Sano K: Changes in the contralateral dentate gyrus in Mongolian gerbils
subjected to unilateral cerebral ischemia.. Acta Neuropathol (Berl)
50:121-129,1980
255. Kirino T: [A new artificial respirator suited for perfusion fixation of tissues insmall laboratory animals (author's transl)]. Jikken Dobutsu 28:551-554,1979