美原賞受賞者ＣＶと業績抜粋
平成１３年度受賞
慶應義塾大学医学部客員教授

冨田稔
履歴書
昭和 ３４年 ３月
３８年 ４月
４１年 ６月
４３年 １月
４５年 ４月
４６年 ４月
４７年 ８月
平成 元年 ４月
平成 ２年 ４月
７年１１月

慶應義塾大学医学部卒
米国 Detroit, Wane State University
Cerebrovascular Units (JS Meyer)二年半留学
慶應義塾大学医学部大学院卒
冨田病院勤務慶應義塾大学医学部兼任講師（約２０年間）
宮崎医大非常勤講師（約２０年間）
冨田病院院長 現在に至る
岡崎国立生理学研究所共同研究員（３年間）
慶應義塾大学医学部客員助教授（５年間）
慶應義塾大学医学部客員教授 現在に至る

賞罰、資格
昭和 ３5 年 ３月
ECFMG
平成 ６年 ６月
日本医師会学術最高優功賞
平成 13 年 2 月
美原賞受賞
会員
American Heart Association(Council)World Federation of Neurology
New York Academy of Sciences
International Society of Cerebral Blood Flow and Metabolism（Chairman of Membership Committee, 1995-1999
Program Committee for 20th International Symposium on Cerebral Blood Flow andMetabolism (Brain 01, Taipei, June 10-13, 2001)

1

美原賞受賞後における業績 (平成１９年２月現在)（Medline 主要論文のみ）
Tomita M, Ohtomo M, Suzuki N: Contribution of the flow effect caused byshear-dependent RBC aggregation to NIRS spectroscopic signals. NeuroImage 33:1-10,
2006.
Tomita M. Flow effect impacts NIRS, jeopardizing quantification of tissue hemoglobin.
Neuroimage 33: 13-6, 2006.
Tomita M, Tanahashi N, Takeda H, Schiszler I, Osada T, Unekawa M, Suzuki N.
Capillo-venous flow in the brain: significance of intravascular RBC aggregation forvenous flow regulation. Clinical Hemorheology and Microcirculation. 34: 51-57, 2006.
Osada T, Tomita M, Suzuki N. Spindle-shaped constriction and propagated dilation ofarterioles during cortical spreading depression. Neuroreport.17:1365-8, 2006.
Tomita M, Schiszler I, Tomita Y, Tanahashi N, Takeda H, Osada T, Suzuki N: Initialoligemia with capillary flow stop followed by hyperemia during K+-induced corticalspreading depression in rats. J Cereb Blood Flow Metab. 25(6):742-7. 2005.
Tomita M: Increased intracranial pressure and brain edema. In ISN Book Series,
Pathology & Genetics, Structure and functions of CNS blood vessels, Cerebrovascular
Diseases, Chapter 5, edited by Hannu Kalimo, (2005) pp39-49.
Tomita M, Tanahashi N, Takeda H, Takao M, Tomita Y, Amano T, Fukuuchi Y.
Astroglial sewlling in the neuronal depolarization ensemble. Acta Neurochir 86:
219-222, 2003.
Inoue K, Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takao M, Takeda H,
Yokoyama M. Dynamic observation of oxygenation-induced contraction of andtransient fiber-network formation/disassembly in cultured human brain microvascularendothelial cells. J Cereb Blood Flow Metab. 23 (7), 821-828, 2003.
Tomita Y, Tomita M, Schiszler I, Amano T, Tanahashi N, Kobari M, Takeda H, Ohtomo
M, Repetitive concentric wave-ring spread of oligemia/hyperemia in the sensorimotor
cortex accompanying K(+)-induced spreading depression in rats and cats.
2

Neurosci Lett. 322(3):157-60, 2002.
Tomita Y; Tomita M; Schiszler I; Amano T; Tanahashi N; Kobari M; Takeda H; Ohtomo
M; Fukuuchi Y: Moment analysis of microflow histogram in focal ischemic lesion toevaluate microvascular derangement following small pial arterial occlusion in rats. J
Cereb Blood Flow Metab 22(6): 663-669, 2002.
Tomita M, Schiszler I, Fukuuchi Y, Amano T, Tanahashi T, Kobari M, Takeda H, Tomita
Y, Ohtomo M, Inoue K. A time-variable concentric wave-ring increase in lighttransparency and associated microflow changes during a potassium-induced spreading
depression in the rat cerebral cortex. In Neuronal Activation and Microcirculation. M.
Tomita, K. Kanno, E. Hamel, Eds., Elsevier Science, B.V., ICS 1235, Amsterdam, 2002,
pp439-447.
Takao M, Kobari M, Tanahashi N, Tomita M, Yokoyama M, Tomita Y, Otomo M, Inoue
K, Fukuuchi Y. Dilatation of cerebral parenchymal vessels mediated by angiotensin type
1 receptor in cats. Neurosci Lett. 318(2):108-12, 2002.

Tomita Y, Tanahashi N, Tomita M, Itoh Y, Yokoyama M, Takeda H, Schiszler I,
Fukuuchi Y. Role of platelet glycoprotein IIb/IIIa in ADP-activated platelet adhesion toaortic endothelial cells in vitro: observation with video-enhanced contrast microscopy.
Clin Hemorheol Microcirc. 2001;24(1):1-9.
Tanahashi N, Fukuuchi Y, Tomita M, Tomita Y, Inoue K, Satoh H, Abe T. Adhesion of
adenosine diphosphate-activated platelets to human brain microvascular endothelial
cells under flow in vitro is mediated via GPIIb/IIIa. Neurosci Lett. 2001;301(1):33-6.
Tomita M, Schiszler I, Fukuuchi Y, Amano T, Tanahashi T, Kobari M, Takeda H, Tomita
Y, Ohtomo M, Inoue K. A time-variable concentric wave-ring increase in lighttransparency and associated microflow changes during a potassium-induced spreading
depression in the rat cerebral cortex. In Neuronal Activation and Microcirculation. M.
Tomita, K. Kanno, E. Hamel, Eds., Elsevier Science, B.V., INS 1235, Amsterdam, 2002,
pp 439-447
Schiszler I, Tomita M, Inoue K, Tanahashi N, Fukuuchi Y. Sustained microvascularflow response to functional activation in rat cerebral cortex. In Neuronal Activation andMicrocirculation. M. Tomita, K. Kanno, E. Hamel, Eds., Elsevier Science, B.V.,
International Congress Series 1235, Amsterdam, 2002, pp 173-179

3

Tomita M, Fukuuchi Y, Tanahashi N, Tanaka K, Kobari M, Takao M, Tomita Y, Ohtomo M,
Inoue M, Schiszler I Evolution of microvascular derangement in a small area of the rat
cerebral cortex following occlusion of a pial arterial branch as observed by the novel
photoelectric method. In: Maturation Phenomenon in Cerebral Ischemia IV, Edited by
N.G.Bazan, U. Ito, V.L. Marcheselli, T. Kuroiwa, I. Klatzo, Springer, Berlin-HeidelbergTokyo, 2001, pp 165-170.

4美原賞受賞時までの業績 (平成１３年２月現在)
国際学会、シンポジウム主宰、および著書
１． 昭和６３年６月、サテライトシンポジウム“脳虚血と充血”, 会長（第４回世界微小循環学会、土屋雅春会長）, 大阪。
Proceedings: Cerebral Hyperemia and ischemia - From theStandpoint of Cerebral Blood Volume, Tomita M, Sawada T,
Naritomi H, Heiss WD, eds.: Int. Natl. Congr. Ser.
著書１764, Excerpta Medica, Amsterdam, 1988
２. 平成２年４月、第 VI 回トビリシ国際シンポジウム、“脳微小循環”, オーガナイザーMchedlishvili G, Tomita
M, and Tuma RF、トビリシ。
Proceedings: Microcirculation of the Brain, Mchedlishvili G,
Tomita M, Tuma RF, eds., Nova Science Publ. Inc.,
著書２
New York, 1992
３. 平成５年５月、国際学会、“脳微小循環障害”, 会長、東京。
Proceedings：Microcirculatory Stasis in the Brain, Tomita M,
Mchedlishvili G, Rosenblum WI, Heiss W-D, Fukuuchi Y,eds., Int. Natl. Congr. Ser. 764, Excerpta Medica, Amsterdam,
1993
著書３

４. 平成８年５月、国際シンポジウム、“脳虚血､サイトカイン、細胞動員”,
会長福内靖男、オーガナイザー冨田稔､東京。
Proceedings: Ischemia, Cytokines and Cellular Mobilization in the Brain,
Fukuuchi Y, Tomita M, eds., Keio J. Med. 45: 174-274, 1996
５. 平成８年１０月、第５回ヨーロッパ微小循環学会シンポジ
ウム、組織委員長、“赤血球凝集と脳卒中”、ローマ。
Proceedings: RBC Aggregation and Stroke (Abstract 集)、
Tomita M, Fukuuchi Y eds., at Joint 3rd World Congress and5th European Microcirculation, Rome、1996
著書５

６. 平成１1 年６月、国際脳循環代謝学会のシンポジウム、組織委員長、(Brain 99)、
“脳循環調節：神経と化学性調節”、コペンハーゲン。
Proceedings: Chemical and neural control of the cerebral circulation, at Brain 99,
5Copenhagen, June、2000, Regulation of cerebral microcirculation: update.
Tomita, N. Suzuki, E. Hamel, D. Busija, M. Lauritzen: Keio J. Med.;
49(1):26-34, 2000
７. 平成１１年１０月、慶應国際シンポジウム（坂口記念）、“虚血脳血流”, 会長福内靖男、
オーガナイザー冨田稔、厚東篤生、東京。
Proceedings: Ischemic Blood Flow in the Brain, Fukuuchi
Y, Tomita M, Koto A, eds., Springer,
Tokyo-Berlin-Heidelberg, 1999
著書７

８. 平成１１年６月、第７回トビリシインターネットシンポジウム、“虚微小循環とヘモレオロジー：病理的変化”、オーガナイザーMchedlishvili G,
Tomita M, Schmid-Schönbein、トビリシ-東京-サンジェゴ。
Proceedings: Hemorheology in Microcirculation: Pathological Changes, Internet
Virtual Symposium, The 7th Tbilisi Symposium, Mchedlishvili G, Tomita M,
Schmid-Schönbein eds., Keio J Med 49 (Suppl 3), 2000
９. 平成１3 年６月、国際脳循環代謝学会のサテライトシンポジウム (Brain 01)、
“脳活性化と微小循環調節”､会長、東京。
Proceedings: Brain Activation and CBF Control, Tomita M,
Kanno I, Hamel Edith eds., Elsevier Science BV, ICS 1235,
2002

プログラム集本は印刷中

１０. 平成１3 年６月、国際脳循環代謝学会シンポジウム (Brain 01)“脳微小循環”, Organizer and Chairman, 台北
Peter Gaehtgens：Glycocalyx, tissue hematocrit, and microcirculation
Martin Lauritzen：Spreading depression and mircrocirculation
Minoru Tomita：Local hierarchial vascular perturbation during spreading
depression
Ute Lindauer：Nitric oxide and neurovascular coupling: trouble in paradise6美原賞受賞までの主要業績
１） Tomita M, Gotoh F, Sato T, Amano T, Tanahashi N, Tanaka K, Yamamoto M:
Photoelectric method for estimating hemodynamic changes in regional cerebral
tissue. Am J Physiol 235:H56-H63, 1978（組織の血液含量を光学的に測定する。
これは Lambert-Beer の法則を応用したはじめての論文であったが、１０年後にBriton Chance が同じことを報告、それの方が有名になった。現在の多くの内因的な光シグナル測定の基本となっているもの）。
２） Tomita M, Gotoh F, Amano T, Tanahashi N, Kobari M, Shinohara T, Mihara B:
Transfer function through regional cerebral cortex evaluated by a photoelectric
method. Am J Physiol 245:H385-H398, 1983 （統計学のモーメント分析を組織血
液通過時間の頻度関数にあてはめ、微小循環パラメーターの定量化をした）。
３） Tomita M, Gotoh F, Amano T, Tanahashi N, Tanaka K: "Low perfusion hyperemia"
following middle cerebral arterial occlusion in cats of different age groups. Stroke
11:629-636, 1980 （脳虚血病巣において血流が低いにもかかわらず血液が充満してくる現象の報告。その後多くの施設で PET, fMRI などで証明された）。
４） Gogolak I, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Mihara B: No
intracerebral steal phenomenon in the ischemic brain following papaverine
administration. Stroke 16:114-117, 1985 （血管拡張剤が脳卒中にスチール現象が起るため禁忌とされていたが、そんなものは起らないという論文。これ以後カル
シュウム拮抗剤が使われるようになった）。
５） Tomita M, Gotoh F, Tanahashi N, Turcani P: Whole-blood red cell aggregometerfor human and feline blood. Am J Physiol 251:H1205-H1210, 1986 （同じ血液の透過光が血流依存性に大きく変化することを見出した）。
６） Tomita M, Gotoh F: Cascade of cell swelling (cytotoxic edema): Thermodynamic
potential discharge of brain cells following membrane injury. Am J Physiol
262:H603-H610, 1992 （細胞が機能するとき、あるいは細胞膜が傷害された時に自発的に膨化する事実の証明と非平衡熱力学に基づいた解釈）。
７） Istvan Schiszler, Minoru Tomita, Yasuo Fukuuchi, Norio Tanahashi, Koji Inoue:
New optical method for analyzing cortical blood flow heterogeneity in small
animals - validation of the method. Am J Physiol 279:H1291-1298, 2000 （毛細血管レベルの血流変化の二次元的な表示方法）。

7

外国からの研究者との共同研究､指導後藤文男主任教授
１）Sandor, P.：ハンガリーよりSandor P, Gotoh F, Tomita M, Tanahashi N, Gogolak I: Effects of a stable enkephalin
analogue, (D-Met2,Pro5)-enkephalinamide, and naloxone on cortical blood flow andcerebral blood volume in experimental brain ischemia in anesthetized cats. J Cereb
Blood Flow Metab 6:553-558, 1986２）Gogolak, I.: チェコよりGogolak I, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Mihara B: No
intracerebral steal phenomenon in the ischemic brain following papaverine
administration. Stroke 16:114-117, 1985
３）Gerdsen, I.: ドイツよりTomita M, Gotoh F, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K, Gerdsen I:
Comparison between the photoelectric method and H2 clearance method for measuring
cerebrocortical blood flow in cats. J Cereb Blood Flow Metab 8:727-732, 1988
４）Turcani, P.: スロバックよりTurcani P, Gotoh F, Tomita M, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K:
Role of platelets and leukocytes in the development of low perfusion hyperemia in the
cerebral ischemic area of cats. In Cerebral vascular disease 6. Meyer JS, Lechner H,
Reivich M, Ott EO(Eds.) Excerpta Medica, pp285-289, 1987５）Haapaniemi, H.: フィンランドより
Haapaniemi H, Tomita M, Tanahashi N et al. Non-amoeboid locomotion of cultured
microglia obtained from newborn rat brain. Neurosci Lett 193:121-124, 1995
福内靖男主任教授
６）Schiszler, I.: ハンガリーよりSchiszler I, Tomita M, Fukuuchi Y, Tanahashi N, Inoue K: New optical method foranalyzing cortical blood flow heterogeneity in small animals - validation of the method.
Am J Physiol 279:H1291-1298, 2000

8

業績一覧
原著（英文のみ）
目次
I．
II．
III．
IV．
V．
VI．

脳循環生理関係（方法論を含む）
1 - 52脳血管障害関係
53 - 90
脳浮腫関係
91 - 101
赤血球凝集、ヘモレオロジー関係
102 - 139
神経細胞、グリア(C6)、マイクログリア培養細胞ならびに白血球、血小板関係
140 - 174
１９７０年以前の業績
175 - 185

I. 脳循環生理関係（方法論を含む）

1. Tomita M, Gotoh F, Sato T, Amano T, Tanahashi N, Tanaka K, Yamamoto M: Photoelectric
method for estimating hemodynamic changes in regional cerebral tissue. Am J Physiol
235:H56-H63, 1978
2. Tomita M, Gotoh F, Sato T, Amano T, Tanahashi N, Tanaka K, Yamamoto M: Comparative
responses of the carotid and vertebral arterial systems of rhesus monkeys to betahistine. Stroke
9:382-387, 1978
3. Tomita M, Gotoh F, Sato T, Amano T, Tanahashi N, Tanaka K: Distensibility of cerebral vessels
in response to acute hypertension in cats. Keio J Med 28:151-163, 1979
4. Tomita M, Gotoh F, Sato T, Tanahashi N, Tanaka K: 4-6 cycle per minute fluctuation in cerebral
blood volume of feline cortical tissue in situ. J Cereb Blood Flow Metab 1 (Suppl 1), S443-S444,
1981
5. Tomita M, Gotoh F: Rearranged equation for determining local cerebral glucose utilization. Ann
Neurol 10:65, 1981
6. Tomita M, Gotoh F: Local cerebral blood flow values as estimated with diffusible tracers:
Validity of assumptions in normal and ischemic tissue. J Cereb Blood Flow Metab 1: 403-411,
1981
7. Tomita M, Gotoh F, Tanahashi N,Tanaka K, Kobari M: Ipsilateral increase in CBV by unilateralsevering of the cervical synpathetic preganglionic fiber in cats. In Cerebral blood flow:Effects ofnerves and neurotransmitters. Heistad DD, Marcus ML, Eds., Elsevier, North Holland,
pp403-408, 1982
8. Tomita M, Gotoh F, Tanahashi N, Tanaka K, Kobari M: Photoelectric method for studying theintraparenchymal circulation. In Basic aspects of microcirculation. Tsuchiya M et al (Eds.)
Elsevier, Excerpta Medica, Amsterdam, pp61-74,1982

9

9. Tomita M, Gotoh F, Sato T, Tanahashi N, Tanaka K, Kobari M: The vertebral arterial system inrhesus monkeys is less efficient in autoregulation of blood flow than the internal carotid arterial
system. In Cerebral vascular disease 4. Meyer JS, Lechner H, Reivich M, Ott EO, Eds., Elsevier,North Holland, pp48-52, 1982
10. Tomita M, Gotoh F: Which circulates faster through the cerebral microcirculatory system, redcells or plasma? Stroke 13:722, 1982
11. Tomita M, Gotoh F, Amano T, Tanahashi N, Kobari M, Shinohara T, Mihara B: Transfer
function through regional cerebral cortex evaluated by a photoelectric method. Am J Physiol
245:H385-H398, 1983
12. Amano T, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Mihara B: Hemodynamicchanges in feline sensorimotor cortices and autonomic nerve activity during penicillin-induced
seizures. In Cerebral blood flow, metabolism and epilepsy.

Baldy-Moulinier M et al., Eds.,

John Libbey & Company, pp135-141, 1983,
13. Tomita M, Gotoh F, Amano T, Tanahashi N, Kobari M, Shinohara T, Mihara B: Redistribution ofblood flow between the intra and extracranial arterial systems on induced hypotension within the
autoregulatory range in cats. J Cereb Blood Flow Metab 3 (Suppl.1):S644-S645, 1983
14. Kobari M, Gotoh F, Tomita M, Shinohara T, Terayama Y, Mihara B, Turcani P: "CO2 type"and "papaverine type" increases in cerebrocortical blood flow with respect to microvascularflow pattern. In Microcirculation Annual 1985. Tsuchiya M, Asano M, Oda M, Okazaki I, Eds.,
Excerpta Medica, Amsterdam, pp149-155, 1985
15. Kobari M, Gotoh F, Tomita M, Tanahashi N, Shinohara T, Terayama Y, Mihara B, Turcani P:
Dissociation between the changes in intracranial pressure and cerebral blood volume following
administration of histamine. Acta Neurol Scand 72 (Suppl.):124, 1985)
16. Sandor P, Gotoh F, Tomita M, Tanahashi N, Gogolak I: Effects of a stable enkephalin analogue,(D-Met2, Pro5)-enkephalinamide, and naloxone on cortical blood flow and cerebral blood
volume in experimental brain ischemia in anesthetized cats. J Cereb Blood Flow Metab
6:553-558, 1986
17. Tomita M, Gotoh F, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K,

Gerdsen I:

Comparison between the photoelectric method and H2 clearance method for measuring
cerebrocortical blood flow in cats. J Cereb Blood Flow Metab 8:727-732, 1988
18. Tomita M: Merits and demerits of the photoelectric method for measuring cerebral blood
volume. In Cerebral Hyperemia and ischemia - From the Standpoint of Cerebral Blood Volume,
ICS 764, Tomita M, Sawada T, Naritomi H, Heiss WD, Eds., Elsevier, Amsterdam, pp237-245,
1988
19. Tomita M: Significance of Cerebral Blood Volume. In Cerebral Hyperemia and Ischemia - From
the Standpoint of Cerebral Blood Volume, ICS 764, Tomita M, Sawada T, Naritomi H, Heiss
WD, Eds., Elsevier, Amsterdam, pp3-31, 1988
20. Tomita M, Gotoh F, Tanahashi N, Shinohara T, Terayama T, Mihara B, Ohta K:

Indicator

dilution curves and heterogeneity in tissue perfusion -analysis of a microvascular model- In
Microcirculation Annual 1989. Asano M et al., Eds., Nihon-Igakukan, Tokyo, pp7-8, 198910

21. Tomita M, Gotoh F: Functional interpretation of tissue indicator dilution curves and its
verification. Int J Microcirc 8 (Suppl.1):S33, 1989.
22. Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Yamawaki T, Mihara B,
Ohta K, Kaneko A: Mechanical filtration rate (Lp) of the membrane of cultured glioma cells(C6). In Brain Edema 1990. Reulen HJ, Baethman A, Fenstermacher J, Marmarou A, Spatz M,
Eds., Minerva, Acta Neurochir, Suppl.51, pp11-13, 1990
23. Tomita M, Gotoh F: Capillary recruitment of the cerebral cortex during CO 2 inhalation. Fact orillusion? J Cereb Blood Flow Metab 10:294, 1990
24. Ohta K, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B,
Takeda H: Species differences in red blood cell aggregability. In Microcirculation Annual 1990.
Tsuchiya M, Asano M, Shozawa T, Eds. Nihon-Igakukan, Tokyo, pp17-18, 1990
25. Takeda H, Tomita M, Fukuuchi Y, Tanhashi N, Kobari M, Shinohara T, Ohta K, Matsuoka S:
Photoelectric method for noninvasive repeated measurement of relative cerebral blood flow insmall animals. Microcirc Ann; 77-78, 1992.
26. Tomita M, Fukuuchi Y, Amano T, Tanahashi N, Kobari M, Terayama Y, Shinohara T, Matsuoka
S, Takeda H: Rapid increase of cortical blood flow in response to local flow stimulus by
benzylpenicilllin potassium. J Cerebrl Blood Flow and Metab 13 (Suppl 1): 17, 1993.
27. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Matsuoka S, Takeda:H: Ectopic
ventricular beats invaribly reduce cerebral blood volume and blood flow in anesthetized cat. J
Cerebrl Blood Flow and Metablism.13 (Suppl 1): 425, 1993.
28. Takeda H, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Shinohara T, Ohta K, Matsuoka S:
Photoelectric method for noninvasive repeated measurement of relative cerebral blood flow insmall animals. J Cereb Blood Flow and Metab 13 (Suppl 1): 805, 1993.
29. Tomita M, Fukuuchi Y: Bi-hemisheric oscillations of cerebral blood volume may be paced by
local microvascular autonimies in cats. Int J Microcir 11; S156-88, 1993.
30. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Konno S, Takeda H: Effect of sumatriptan on
the cerebral intraparenchymal microcirculation in the cat. Br. J. Pharmacol 110; 1445-1448,
1993.
31. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Konno S, Takeda H, Ito D:
Cerebral hemodynamic effects of experimental cardiac arrhythmias. Niini H (eds) Progress in
Microcirculation Research 351-354, 1993
32. Kobari M., Y. Fukuuchi, M. Tomita, N. Tanahashi, T. Yamawaki, H. Takeda, Matsuoka S:
Transient cerebral vasodilatory effect of neuropeptide Y mediated by mitric oxide. Brain
Research Bulletin 31; 443-448, 1993.
33. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Konno S, Takeda H: Constriction/dilatation of
the cerebral microvessels by intravascular endothelin-1 in cats. J Cereb Blood Flow Metab 14:
64-69, 1994
34. Kobari M,

Fukuuchi Y, Tomita M, Tanahashi N, Takeda H: Role of nitric oxide in regulation of

cerebral microvascular tone and autoregulation of cerebral blood flow in cats. Brain Research
667 pp. 255-262, 199411

35. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Takeda H, Yokoyama M: Calcitonin
gene-related peptide (CGRP) and the regulation of cerebral parenchymal vessels. Brain
Research 698: 95-99, 1995
36. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Takeda H: Effects of ventricular arrhythmia on
the cerebral microcirculation in cats. Neurol Res 17: 73-77, 1995
37. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Terayama Y, Takeda H, Yokoyama
M: Functional role of calcitonin gene-related peptide (CGRP) in the regulation of
cerebrocortical microvessels. J Cereb Blood Flow Metab 15 (Suppl 1): S534, 1995
38. Tanahashi N, Tomita M, Kobari M, Takeda H, Yokoyama M, Fukuuchi Y: Aspirin improves theenhanced erythrocyte aggregability in patients with cerebral infarction. J Neurol Sci 139:
137-140, 1996
39. Takao M, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Takeda H,
Yokoyama M, Ito D: Cerebral vasodilatation by adrenomedullin in the cat. J Cereb Blood
Flow and Metab 17 (suppl): S350,1997
40. Kobari H, Fukuuchi Y, Tomita M, Tanahashi N, Yokoyama M, Takao M: Tachykinin NK1
receptor mediates substance P-induced dilatation of cerebral parenchymal microvessels in cats. J
Cereb Blood Flow and Metab 17 (suppl): S756,1997
41. Takao M, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Shinohara T, Tomita Y, Otomo M,
Inoue K: Vasodilatory effects of angiotensin II on the cerebral parenchymal vessels of cats
(abstr.). J CBF & Metabol 19 (Sppl. 1): S743, 1999
42. Schiszler I, Tomita M, Fukuuchi Y, Tanahashi N, Inoue K: Novel photoelectric method foranalyzing cortical blood flow heterogeneity in small animals - validationof the method (abstr.). J
CBF and Metab 19 (Sppl. 1): S622, 1999
43. Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Yokoyama M, Inoue K, Schiszler I:
Atmospheric electrification of brain cells: Possible role in generation of a DC potential (abstr.). J
CBF and Metab 19 (Sppl. 1): S708, 1999
44. Tomita M, Suzuki N, Hamel E, Busija D, Lauritzen M: Regulation of cerebral microcirculation
update. Keio J. Med; 49(1):26-34, 2000
45. Schiszler I, Tomita M, Fukuuchi Y, Tanahashi N, Inoue K: Heterogeneity of autoregulatory
capacity in the rat brain as observed by a novel 2-d flow mapping technique. In: Ischemic Blood
Flow in the Brain, Y. Fukuuchi, M. Tomita, A. Koto, eds, Springer-Verlag, Tokyo, 2000,
pp282-288
46. Tomita M, Fukuuchi Y: Ischemic blood flow values in the brain as influenced by the m factor.
In: Ischemic Blood Flow in the Brain, Y. Fukuuchi, M. Tomita, A. Koto, eds, Springer-Verlag,
Tokyo, pp256-261, 2000
47. Schiszler I, Tomita M, Fukuuchi Y, Tanahashi N, Inoue K: New optical method for analyzing
cortical blood flow heterogeneity in small animals - validation of the method. Am J Physiol
279:H1291-1298, 2000
48. Schiszler I, Tomita M, Fukuuchi Y, Tanahashi N, Inoue K. Heterogeneous autoregulatory
capacity in the rat cerebral cortex as observed by a novel two-dimensional flow mapping12

technique. In: Ischemic Blood Flow in the Brain. Y. Fukuuchi, M. Tomita, A. Koto, Eds., Keio
University

Symposia

for

Life

ScienceandMedicine,

Volume6,

Springer,

Tokyo-Berlin-Heidelberg, pp 282-288, 2001
49. Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Tomita Y, Ohtomo M. Heterogeneity of“microflow” changes within a cortical area as small as an LDF probe. J Cereb Blood Flow
Metabol 21 (Suppl. 1): S228, 2001
50. Tomita Y, Schiszler I, Tomita M, Tanahashi N, Inoue K, Fukuuchi Y. Wave-ring spreadingchanges in tissue transparency induced by topical potassium ion application in rat sensorimotor
cortex. J Cereb Blood Flow Metabol 21 (Suppl. 1): S225, 2001
51. Tomita M, Schiszler I, Fukuuchi Y, Amano T, Tanahashi T, Kobari M, Takeda H, Tomita Y,
Ohtomo M, Inoue K. A time-variable concentric wave-ring increase in light transparency andassociated microflow changes during a potassium-induced spreading depression in the rat
cerebral cortex. In Neuronal Activation and Microcirculation. M. Tomita, K. Kanno, E. Hamel,Eds., Elsevier Science, B.V., International Congress Series 1235, Amsterdam, 2002, in press
52. Schiszler I, Tomita M, Inoue K, Tanahashi N, Fukuuchi Y. Sustained microvascular flow
response to functional activation in rat cerebral cortex. In Neuronal Activation andMicrocirculation. M. Tomita, K. Kanno, E. Hamel, Eds., Elsevier Science, B.V., International
Congress Series 1235, Amsterdam, 2002, in press

II. 脳血管障害関係
53. Tomita M, Gotoh F, Amano T, Tanahashi N, Tanaka K: "Low perfusion hyperemia" following
middle cerebral arterial occlusion in cats of different age groups. Stroke 11:629-636, 1980
54. Tanaka K, Gotoh F, Tomita M, Sato T, Amano T, Tanahashi N, Kobari M: Acceleration ofregional flow through feline cerebral ischemic tissue following intravenous administration ofpentoxifylline. In Pathophysiology and Pharmacotherapy of Cerebrovascular Disorders. Betz E
et al., Eds., Excerpt Med, Amsterdam, pp294-298, 1980
55. Tomita M, Gotoh F, Sato T, Tanahashi N, Tanaka K, Kobari M: Low perfusion hyperemia andreactive hyperemia in cerebral cortex following middle cerebral artery occlusion in cats. In
Cerebral Vascular Disease 3. Meyer JS, Lechner H, Reivich M, Ott EO, Eds., Excerpta Medica,
Amsterdam, New York, Oxford, pp 208-213, 1980
56. Tanahashi N, Gotoh F, Tomita M, Tanaka K, Kobari M: Critical duration of middle cerebral
artery occlusion for the production of reactive hyperemia in feline cerebral tissue. J Cereb Blood
Flow Metab 1 (Suppl. 1):S239-S240, 1981
57. Kobari M, Gotoh F, Tomita M, Tanahashi N, Tanaka K: Vulnerability of cerebral venous flow
following middle cerebral arterial occlusion in cats. In The Cerebral Veins. Auer LM, Loew F,
Eds., Springer-Verlag, Wien, pp 287-291, 1983
58. Tanahashi N, Gotoh F, Tomita M, Amano T, Kobari M, Shinohara T, Mihara B: Effect of aging

13

on reactive hyperemia following reopening of occluded middle cerebral artery in cats. Eur
Neurol 22 (Suppl.2):6-7, 1983; Monogr Neural Sci 11:40- 46, 1984
59. Gogolak I, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Mihara B: No
intracerebral steal phenomenon in the ischemic brain following papaverine administration.
Stroke 16:114-117, 1985
60. Tomita M, Gotoh F, Tanahasi N, Kobari M, Shinohara T, Mihara B: Role of the osmotic
potential in the development of cytotoxic edema. Symposium on the Blood-Brain-Barrier. Acta
Neurol Scand (Suppl.) 72:113-114, 1985
61. Tomita M, Gotoh F,Kobari M, Shinohara T, Terayama Y, Mihara B, Turcani P: Autoregulatory
response in cerebral vasculature vs. low perfusion hyperemia following middle cerebral arterial
occlusion in cats. J Proc. Brain 85, 357, 1985
62. Turcani P, Gotoh F, Tomita M, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K: Role ofplatelets and leukocytes in the development of low perfusion hyperemia in the cerebral ischemic
area of cats. In Cerebral vascular disease 6. Meyer JS, Lechner H, Reivich M, Ott EO, Eds.,
Excerpta Medica, pp285-289, 1987
63. Shinohara T, Tomita M: Closure of thoroughfare channels at low perfusion hyperemia in
ischemic cerebral tissue.

In Cerebral Hyperemia and Ischemia - From the Standpoint of

Cerebral Blood Volume ICS 764. Tomita M, Sawada T, Naritomi H, Heiss WD, Eds., Elsevier,
Amsterdam, pp141-150, 1988
64. Tomita M, Sawada T, Naritomi H, Heiss WD, Eds.: Cerebral Hyperemia and Ischemia - From
the Standpoint of Cerebral Blood Volume, ICS 764. Elsevier, Amsterdam, 1988
65. Tanahashi N: Cerebral microvascular reserve for hyperemia. In Cerebral Hyperemia andIschemia - From the Standpoint of Cerebral Blood Volume ICS 764. Tomita M, Sawada T,
Naritomi H, Heiss WD, Eds., Elsevier, Amsterdam, pp173-182, 1988
66. Kobari M, Gotoh F, Tomita M, Tanahashi N, Shinohara T, Terayama Y, Mihara B: Bilateralhemispheric reduction of cerebral blood volume and blood flow immediately after experimental
cerebral hemorrhage in cats. Stroke 19:991-996, 1988
67. Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B, Ohta K:
Hemodynamic changes in the dorsal part of the upper medulla during the Cushing response incats. Stroke 21(Suppl.1):I-60,1990
68. Shinohara T, Gotoh F, Tomita M, Tanahashi N, Terayama Y, Mihara B, Yamawaki T, Ohta K:
Reactive hyperemia produced by a short period of cardiac arrest in cats. Stroke21(Suppl.1):I-81,1990
69. Tomita M, Gotoh F, Tanahashi N, Shinohara T, Terayama Y, Mihara B, Ohta B: Spontaneous
periodic fluctuation of cerebral blood volume induced by anti-platelet serum and abolished bymiddle cerebral artery occlusion in cats. 14th Internat Symp on Cerebral Blood Flow andMetabolism. J Cereb Blood Flow Metab 9 (Suppl.1):S457, 1989)
70. Tanahashi N, Gotoh F, Tomita M, Shinohara T, Terayama Y, Mihara B, Ohta K, Nara M: Red
blood cell aggregability in occlusive cerebrovascular disease - Comparison between deep
subcortical infarction and cortical infarction. Stroke 21 (Suppl.1):I-126,1990

14

71. Tomita M, Gotoh F, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K: Effect of diltiazemon the cortical microcirculation in acutely produced cerebral ischemia in cats. In Cerebral
Ischemia and Calcium. Hartmann A, Kuschinsky W, Eds., Springer-Verlag, Berlin, Heidelberg,
pp292-298, 1989
72. Mihara B, Gotoh F, Tomita M, Tanahashi N, Shinohara T, Terayama Y, Ohta K: Morphologicalchanges of cerebral

microcirculatory system in the brain swelling of vascular origin. In

Microcirc Ann 1989. Asano M et al., Eds., Nihon-Igakukan, Tokyo, pp49-50, 1989
73. Ohta K, Gotoh F, Tomita M, Tanahashi N, Shinohara T, Terayama Y, Mihara B: Nitroglycerinincreases cerebral blood volume and flow in cerebral ischemic area in spite of raised intracranialpressure. Neurology India 37 (Suppl.):116, 1989
74. Tomita M, Gotoh F, Tanahashi N, Shinohara T, Terayama Y, Mihara B, Ohta K: Spontaneous
periodic fluctuation of cerebral blood volume induced by anti-platelet serum and abolished bymiddle cerebral artery occlusion in cats. J Cereb Blood Flow Metab 9 (Suppl.1):S457, 1989
75. Ohta K, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B:
Effect of glycerol on the hemodynamics of acutely induced ischemic area in the cerebral cortex
of cats. In Advances in Neurol 52, Brain Edema. Pathogenesis, Imaging, and Therapy. Long DM
et al, Eds., Raven Press, New York, pp 275-284, 1990
76. Mihara B, Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Yamawaki T, Terayama Y,
Ohta K, Takeda H: Microcirculatory derangement following cardiac arrest of short duration. In
Cerebral Vascular Disease 8. Loeb C, Lechner H, Meyer JS et al., Eds., Excerpta Medica, pp.
39-42, 1991
77. Kobari M, Gotoh F, Tomita M, Tanahashi N, Shinohara T, Yamawaki T, Ohta K, Matuoka S,
Takeda H: Cerebral circulation during and after transient ventricular tachycardia in cats. J Cereb
Blood Flow and Metab 11(suppl.2):S531,1991
78. Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B, Yamawaki T,
Ohta K, Matsuoka S, Takeda H: Residual oxygen metabolism of the cat brain in the complete
ischemic tissue - A polarographic method for measuring flow and metabolism in the microregion-. Maturation Phenomenon in Cerebral Ischemia. Ito U, Klatzo I, Eds., Springer-Verlag, Berlin,
Heidelberg, 1991
79. Kobari M, Gotoh F, Tomita M, Tanahashi N, Shinohara T, Yamawaki T, Ohta K, Matuoka S,
Takeda H, Nara M: Role of leukocytes in the hemodynamics of acute cerebral ischemia in cats.
Tsuchiya M,Asano M,Katori M :Microcirculation Annual 1991, Nihon-Igakukan, Tokyo,
P195-196, 1991
80. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Yamawaki T, Ohta K Takeda H:
Cerebral microcirculatory changes during and following transient ventricular tachycardia in cats.
J Neurol Sci 111:153-157,1992
81. Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Shinohara T, Yamawaki T, Konno S, Takeda H:
Platelet-activating

factorantagonist(TCV-309)

ameliorates

post-ischemic

delayedhypoperfusion after 30-s cardiac arrest in cats. In Microcirculatory Stasis in the Brain, M.
Tomita, G. Mchedlishvili, W.I. Rosenblum, W.-D. Heiss, and Y. Fukuuchi, eds., Excerpta Medica,

15

ICS 1031, Amsterdam, 1993
82. Kobari , Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Yamawaki T, Konno S, Takeda H:
Effects of 10 s ventricular arrhythmia on the cerevral blood volume in cats: tachycardia versus
fibrillation. Can J Neurol Sci 20 (Suppl 4): S9, 1993
83. Tomita M, Fukuuchi Y: Leukocytes, macrophages and secondary brain damage following
cerebral ischemia. Acta Neurochir. (Suppl.) 66: 32-39, 1996
84. Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Terayama Y, Takao M, Tomita Y, Ohtomo M:
Lanoteplase, a novel tissue plasminogen activator, improves microcirculatory disturbance inischemic tissue following permanent middle cerebral artery occlusion in cats (abstr.). J CBF andMetab 19 (Sppl. 1): S195, 1999
85. Kobari M, Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Yamawaki T, Ohta K Takeda H:
Cerebral microcirculatory changes during and following transient ventricular tachycardia in cats.
J Neurol Sci 111:153-157,1992
86. Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Shinohara T, Yamawaki T, Konno S, Takeda H:
Platelet-activating

factorantagonist(TCV-309)

ameliorates

post-ischemic

delayedhypoperfusion after 30-s cardiac arrest in cats. In Microcirculatory Stasis in the Brain, M.
Tomita, G. Mchedlishvili, W.I. Rosenblum, W.-D. Heiss, and Y. Fukuuchi, eds., Excerpta Medica,
ICS 1031, Amsterdam, 1993
87. Kobari , Fukuuchi Y, Tomita M, Tanahashi N, Shinohara T, Yamawaki T, Konno S, Takeda H:
Effects of 10 s ventricular arrhythmia on the cerevral blood volume in cats: tachycardia versus
fibrillation. Can J Neurol Sci 20 (Suppl 4): S9, 1993
88. Tomita M, Fukuuchi Y: Leukocytes, macrophages and secondary brain damage following
cerebral ischemia. Acta Neurochir. (Suppl.) 66: 32-39, 1996
89. Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Terayama Y, Takao M, Tomita Y, Ohtomo M:
Lanoteplase, a novel tissue plasminogen activator, improves microcirculatory disturbance inischemic tissue following permanent middle cerebral artery occlusion in cats (abstr.). J CBF andMetab 19 (Sppl. 1): S195, 1999
90. Tomita M, Fukuuchi Y, Tanahashi N, Tanaka K, Kobari M, Takao M, Tomita Y, Ohtomo M,
Inoue M, Schiszler I Evolution of microvascular derangement in a small area of the rat cerebral
cortex following occlusion of a pial arterial branch as observed by the novel photoelectric
method. In: Maturation Phenomenon in Cerebral Ischemia IV, Edited by N.G.Bazan, U. Ito, V.L.
Marcheselli, T. Kuroiwa, I. Klatzo, Springer, Berlin-Heidelberg- Tokyo, pp 165-170, 2001

III. 脳浮腫関係

91. Tomita M, Gotoh F: Electronic osmometer with rigid membrane of copper ferrocyanide. Keio J
Med 19:163-175, 1970
92. Tomita M, Gotoh F, Yamamoto M, Amano T, Tanahashi N, Tanaka K: Determination of the16

osmotic potential for swelling of cat brain in vitro. Exp Neurol 65: 66-77, 1979
93. Tomita M, Gotoh F, Kobari M, Shinohara T, Terayama Y, Mihara B, Turcani P: Restriction ofcellular swelling and spontaneous increase in the osmolality of the intracellular fluid in a
simplistic cell model. In Brain Edema. Inaba Y, Klatzo I, Spatz M, Eds., Springer Verlag, New
York, Tokyo, pp244-249, 1985
94. Kobari M, Gotoh F, Tomita M, Shinohara T, Terayama Y, Mihara B: Colloid osmotic pressure ofcat brain homogenate relative to autogenous cerebrospinal fluid, measured by means of anelectronic osmometer with a rigid semipermeable copper ferrocyanide membrane. In Brain
Edema. Inaba Y, Klatzo I, Spatz M, Eds., Springer-Verlag, Berlin, pp72-75, 1985
95. Tomita M: Mechanisms of cytotoxic brain edema development. In Brain Edema. Mchedlishvili
G, Cervos-Navarro J, Hossmann KA, Klatzo I, Eds., Akademiai Kiado, Budapest, pp301-308,
1986
96. Nagasawa, M., Tasaka, M., Tomita, M.: Coupled transport of water and ions through membranes
as a possible cause of cytotoxic edema. Neurosci. Lett, 66, 19-24, 1986
97. Terayama Y, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Mihara B: Continuousrecording of focal edema of the cerebral cortex in vivo using sonomicrometry. In Stroke andMicrocirculation. Cervos-Navarro J, Ferszt R, Eds., Raven Press, New York, pp263-269, 1987
98. Tomita M, Gotoh F, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K: Thermodynamic
energy for maintaining volume and preventing swelling. J Cereb Blood Flow Metab 7(Suppl.1):S122, 1987
99. Tomita M, Gotoh F, Kobari M: Colloid osmotic pressure of cat brain homogenate separated
form autogenous CSF by a copper ferrocyanide membrane. Brain Reserch 474, 165-173, 1988
100.

Tomita, M., Gotoh, F., Tanahashi, N., Kobari, M., Terayama, Y., Yamawaki, T., Mihara,

B., Ohta, K., Kaneko, A.: The mechanical filtration coefficient (Lp) of the cell membrane ofcultured glioma cells (C6). Acta Neurochir (Suppl) 51: 11-13, 1990
101.

Tomita M, Gotoh F: Cascade of cell swelling (cytotoxic edema): Thermodynamic

potential discharge of brain cells following membrane injury. Am J Physiol 262:H603-H610,
1992

IV. 赤血球凝集、ヘモレオロジー関係
102.

Tomita M, Gotoh F, Yamamoto M, Tanahashi N, Kobari M: Effects of hemolysis,hematocrit, RBC swelling, and flow rate on light scattering by blood in a 0.26 cm ID transparent
tube. Biorheology 20:485-494, 1983
103.

Tanahashi N, Gotoh F, Tomita M et al: Application of whole blood RBC aggregometer tothe carotid artery, jugular vein, and femoral vein in cats. In Progress in Angiology. Balas P, Ed.,
Edizioni Minerva Medica, pp583-586, 1985
104.

Tomita M, Gotoh F, Tanahashi N, Turcani P: Whole-blood red cell aggregometer forhuman and feline blood. Am J Physiol 251:H1205-H1210, 1986

17

105.

Tomita M, Gotoh F, Tanahashi N, Kobari M, Terayama Y, Mihara B, Ohta K:

Intravascular RBC aggregation and transient diminution of cerebrovascular volume following
middle cerebral artery occlusion in cats. In Cerebral Ischemia and Hemorrheology. Hartmann A,
Kuschinsky W(Eds.) Springer-Verlag, Berlin, New York, pp377-385, 1987
106.

Tomita M, Tanahashi N: RBC aggregometer head as a warning monitor of flow

disturbance in extracorporeal system. Int J Art Org 10:295-300, 1987
107.

Tanahashi N, Gotoh F, Tomita M, Kobari M, Terayama Y, Mihara B, Ohta K. Kasuga Y:

Red blood cell aggregation in pregnancy.

In Microcirculation Annual 1987. Tsuchiya M,

Asano M, Mishima Y, Eds., Nihon-Igakukan, Tokyo, pp127-128, 1987
108.

Tomita M, Gotoh F, Tanahashi N: A trial of the RBC aggregometer head for estimating

blood flow in veins in vivo. Biorheology 25:57-64, 1988
109.

Tanahashi N, Gotoh F, Tomita M, Shinohara T, Mihara B, Ohta K, Nara M: Red blood

cell aggregability in diabetes mellitus. International Journal of Microcirculation. Clinical andExperimental. Martinus Nijhoff Publishers, pS156, 1988
110.

Tanahashi N, Gotoh F, Tomita M, Shinohara T, Terayama Y, Mihara B, Ohta K, Nara M:

Enhanced erythrocyte aggregability in occlusive cerebrovascular disease. Stroke 20:1202-1207,
1989
111.

Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Yamawaki T, Terayama Y,

Mihara B, Ohta K, Takeda H: RBC aggregation is not a primary factor for microvascular stasis
on temporary complete ischemia of the feline brain. In Cerebral Ischemia and Dementia.
Hartmann A, Kuschinsky W, Eds., Springer-Verlag, Berlin, Heidelberg, 1991, pp187-192
112.

Tanahashi N, Gotoh F, Tomita M, Saitoh S, Nakajima S, Nara M: Reduced red blood cellaggregability in chronic renal failure. In Microcirculation Annual 1990. Tsuchiya M, Asano M,
Shozawa T, Eds., Nihon-Igakukan, Tokyo, pp11-12, 1990
113.

Ohta K, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B,

Nara M: Hypertonic glycerol solution improves erythrocyte hyperaggregability in occlusive
cerebrovascular disease. Clin Hemorheol 10:515-524, 1990
114.

Yamawaki T, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y,

Mihara B, Ohta K, Takeda H: Intravascular RBC aggregation in pial vessels during cardiac
arrest in cats - its comparison with ex vivo RBC aggregation. In Microcirculatory Disorders inthe Heart and Brain. Niimi H, Hori M, Naritomi H, Eds., Harwood Academic Publishers,
London, Paris, Philadelphia, Tokyo, Melbourne, pp89-102, 1991
115.

Ohta K, Fukuuchi Y, Tomita M, Tanahashi N, Matsuoka S, Takeda H. Monoclonal

antibody against platelet thrombospondin decreases erythrocyte aggregation rate. Biorheology
1991;28(6):551-6
116.

Ohta K, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B,

Takeda H. Animal species differences in erythrocyte aggregability. Am J Physiol 1992 Apr; 262(4 Pt 2): H1009-12
117.

Ohta K, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Mihara B,

Nara M: Hypertonic glycerol solution improves erythrocyte hyperaggregability in occlusive

18

cerebrovascular disease. Clinical Hemorheology 10; 515-523, 1990.
118.

Yamawaki T, Gotoh F, Tomita M, Tanahashi N, Kobari M, Shinohara T, Terayama Y,

Mihara B, Ohta K, Takeda H: Intravascular RBC aggregation in pial vessels during cardiac
arrest in cats - its comparison with ex vivo RBC aggregation. In Microcirculatory Disorders inthe Heart and Brain. Niimi H, Hori M, Naritomi H, Eds., Harwood Academic Publishers,
London, Paris, Philadelphia, Tokyo, Melbourne, p89-102, 1991
119.

Tanahashi N, Gotoh F, Tomita M, Kobari M, Shinohara T, Yamawaki T, Ohta K, Matuoka

S, Takeda H, Nara M: Erythrocyte aggregability in essential hypertension. Tsuchiya M, Asano M,
Katori M: Microcirc Ann 1991, Nihon-Igakukan, Tokyo, P31-32, 1991.
120.

Ohta K, Fukuuchi Y, Tomita M, Tanahashi N, Matuoka S, Takada H: Monoclonal

antibody against platelet thrombospondin decreases erythrocyte aggregation rate. Biorheology
28; 551-556, 1991
121.

Yamawaki T, Gotoh F, Tomita M, Taahashi N, Kobari M, Shinohara T, Terayama Y,

Mihara B, Ohta K, Takeda H: Intravascular red blood cell aggregation in pial vessels during
cardiac arrest in cats - Comparison with ex vivo red blood cell aggregation. Niimi H, Hori M,
Naritomi H, eds., Microcirculatory Disorders in the Heart and Brain, Harwood Academic
Publisheres Chur, Paris, Philadelphia, Tokyo, Melbourne 89-102, 1991
122.

Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Yamawaki T, Terayama Y,

Mihara B, Ohta K, Takeda H. RBC aggregation is not a primary factor for microvascular stasis
on temporary complete ischemia of the feline brain. In: Cerebral Ischemia and Dementia, edted
by A. Hartmann, W. Kuschinsky, and S. Hoyer, Springer-Verlag, Berlin-Heidelberg, pp187-192,
1992
123.

Ohta K, Gotoh F, Tomita M, Tanahasi N, Kabari M, Shinohara T, Terayama Y, Mihara B,

Takada H: Animal species differences in erythrocyte aggregability. Am J Physiol 262:
H1009-H1012, 1992
124.

Matsuoka S, Fukuuchi Y, Tomita M, Tanahashi N, Takeda H: Differences in erythrocyte

aggregability between multi-infarct dementia and alzheimer's disease, J Stroke 3:102-105,1993
125.

Tanahashi N, Fukuuchi Y, Tomita M, Matsuoka S, Takeda H: Ticlopidine improves theenhanced erythrocyte aggregability in patients with cerebral infarction. Stroke 24, 1083-1086,
1993
126.

Tanahashi N, Fukuuchi Y, Tomita M, Ohta K, Nozaki H, Takeda H: Platelet activationand erythrocyte aggregabillity in patients wih cerebral infarction.Can J Neurol Sci 20; S242,
1993
127.

Takeda H, Fukuuchi Y, Tomita M, Tanahashi N, Konno S: Effects of antiplatelet agents(ticlopidine, aspirin) on erythrocyte aggregability: an in vivo study. Clin Hemorheol 13: 388,
1993
128.

Tanahashi N, Fukuuchi Y, Tomita M, Matsuoka S, Takeda H: Ticlopidine improves theenhanced erythrocyte aggregability in patients with cerebral infarction. Stroke 24 7; 1083-1086,
1993
129.

Tanahashi N, Fukuuchi Y, Tomita M, Matsuoka S, Takeda H: Erythrocyte aggregability in19patients with cerebral infarction with special reference to diabetes mellitus. Clin Hemorheol 13:
253-259, 1993
130.

Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Takeda H, Yokoyama M, Itoh D: Effectof single intravenous administration of batroxobin on erythrocyte aggregability in patients withacute-stage cerebral infarction. Clin Hemorheology: 15: 89-96, 1995.
131.

Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Takeda H, Yokoyama M, Takao M:

Effect of batroxobin on erythrocyte aggregability in patients with acute-stage cerebral infarction.
In: Microcirc Annual 1996. Eds. M Tsuchiya, M Asano and N Tsushima, Nihon-Igakukan,
Tokyo, 81-82, 1996132.

Yokoyama M, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Takeda H, Ito D,

Terakawa S: Effects of high-dose ET-1 on cultured endothelial cells as observed by VEC-DIC
microscopy. In: Microcirculation Annual 1996. Ed. M Tsuchiya, M Asano and N Tsushima,
Nihon-Igakukan, Tokyo, 181-182, 1996
133.

Tanahashi N, Tomita M, Kobari M, Takeda H, Yokoyama M, Fukuuchi Y: Plateletactivation and erythrocyte aggregation rate in patients with cerebral infarction. ClinicalHemorheology 16 (4): 497-505, 1996
134.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Ohta, K,

Takeda H, Yokoyama M: Leukocyte depletion facilitates CBV recovery from early ischemia
following MCA occlusion in cats. J Stroke Cerebrovase Dis 6 (Suppl 1): 19-21, 1996
135.

Tanahashi N, Fukuuchi Y, Tomita M, Takeda H, Yokoyama M, Ito Y, Ito D: Effect ofargatroban on platelet adhesion to thrombin-treated endothelial cells in vitro: Observation by
VEC-DIC microscopy. J Cereb Blood Flow and Metab 17(suppl): S703,1997
136.

Tomita M, Tanahashi N, Kobari M, Takeda H, Inoue K, Fukuuchi Y: Dynamic

observation of erythrocyte flickering phenomena. Microcirculation annual 14: 49-50, 1998
137.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takao M, Tomita Y: Flow-dependent

light scattering by the blood in the brain (abstr.). J CBF and Metab 19 (Suppl. 1): S722, 1999
138.

Tomita Y, Tanahashi N, Tomita M, Itoh Y, Yokoyama M, Takeda H, Schiszler I, Fukuuchi

Y. Role of platelet glycoprotein IIb/IIIa in ADP-activated platelet adhesion to aortic endothelial
cells in vitro: observation with video-enhanced contrast microscopy. Clin Hemorheol Microcirc
24(1):1-9, 2001
139.

Tanahashi N, Fukuuchi Y, Tomita M, Tomita Y, Inoue K, Satoh H, Abe T. Adhesion of

adenosine diphosphate-activated platelets to human brain microvascular endothelial cells underflow in vitro is mediated via GPIIb/IIIa. Neurosci Lett 301(1):33-6, 2001

V. 培養細胞(神経細胞、グリア(C6)、マイクログリア)
ならびに白血球、血小板関係

140.

Tomita M, Gotoh F, Tanahashi N, Shinohara T, Terayama Y, Mihara B, Ohta K: Diffusion20

of oxygen gas is faster through a layer of suspended cultured C6 cells than through the medium.
In Oxygen Transport to Tissue XII. Piiper J, Goldstick TK, Meyer M, Eds., Plenum Press, New
York, pp115-120, 1989
141.

Tomita M, Gotoh F, Shinohara T: Ionic concentration of shifting fluid during

glutamate-induced swelling of cultured glioma cells estimated by the "cytocrit" technique. In
Advances in Neurology 52. Long D et al(Eds.) Raven Press, New York, p558, 1990
142.

Tomita M, Gotoh F, Tanahashi N, Kobari M, Shinohara T, Terayama Y, Ohta K, Matuoka

S, Takeda T: Cell-density dependent facilitation of hydrogen gas diffusion through suspensionsof cultured astrocytoma cells (C6). J Cereb Blood Flow and Metab 11(suppl.2): S471,1991
143.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Shinohara T, KonnoS, Takeda H,

Haapaniemi H: Loss of facilitation of hydrogen gas diffusion in asphyxiated cultured glial cellsuspensions.In Microcirculatory Stasis in the Brain, M. Tomita, G. Mchedlishvili, W.I.
Rosenblum, W.-D. Heiss, and Y. Fukuuchi, eds., Excerpta Medica, ICS 1031, Amsterdam, 1993,
pp 385-390. 1993
144.

Tomita M: The intravascular mediators and endothelium interaction, Symposium on

ischemic stroke, molecular concepts and rational therapy, Can J Neurol Sci 20 (Suppl 4): S9,
1993
145.

Tomita M, Fukuuchi Y, Terakawa S: No appreciable swelling of cultured neurons after

oxygen deprivation, and cell damage occasionally aggravated by oxygen resupply. Cerebral
Ischemia and Basic Mechanisms. A. Hartmann, F. Yatsu, W. Kuschinsky, Eds., Berlin,
Heidelberg, New York: Springer-Verlag, 275-280, 1994
146.

Tomita M, Fukuuchi Y, Terakawa S: Differential behavior of glial neuronal cells exposed

to hypotonic solution. Acta Neurochir (Suppl) 60: 31-33, 1994
147.

Tomita M, Takeda H, Terakawa S: No appreciable swelling of cultured neurons after

oxygen deprivation, and cell damage occasionally aggravated by oxygen resupply. In: Hartmann
A, Yatsu F, Kuschinsky W, Eds., Cerebral Ischemia and Basic Mechanisms. Springer,
Heidelberg, pp 273-280, 1994
148.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Terayama Y, Shinohara T, Konno S,

Takeda H, Itoh D, Yokoyama M, Terakawa S, Haapaniemi H: Activated leukocytes, endothelial
cells, and effects of pentoxifylline: Observations by VEC-DIC microscopy. J Cardiovasc
Pharmacol 25 (Suppl 2): S34-S39, 1995
149.

Haapaniemi H, Tomita M, Tanahashi N et al., Non-amoeboid locomotion of cultured

microglia obtained from newborn rat brain. Neurosci Lett 193:121-124, 1995
150.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Yokoyama M, Ito D,

Terakawa S: Contraction/dilatation of cultured vascular endothelial cells induced byhyperoxia/hypoxia. J Cereb Blood Flow Metab 15 (Suppl 1): S271, 1995
151.

Takeda H, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Yokoyama M, Ito D,

Terakawa S: "Ruffling" of the marginal membranous portion of cultured vascular endothelial
cells as observed by VEC-DIC microscopy. In: Microcirc Annual 1996. M Tsuchiya, M Asanoand N Tsushima, Eds. Nihon-Igakukan, Tokyo, 153-154, 1995

21

152.

Takeda H, Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Yokoyama M, Ito D,

Terakawa S: "Ruffling" of the marginal membranous portion of cultured vascular endothelial
cells as observed by VEC-DIC microscopy. J Cereb Blood Flow Metab 15 (Suppl 1) S558, 1995
153.

Yokoyama M, Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Ito D,

Terakawa S: Effects of NO and ET-1 on porcine cerebrovascular endothelial cells as observed by
VEC-DIC microscopy. J Cereb Blood Flow Metab 15 (Suppl 1): S457, 1995
154.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Yokoyama M, Ito D,

Terakawa S: Swift transformation and locomotion of PMNL and microglia as observed by
VEC-DIC microscopy (video microscopy). Keio J Med 45 (3): 213-224, 1996
155.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Konno S, Takeda H, Yokoyama M,

Takao M, Aoyama M: Long-range coherence in cell-cell attraction. Microcirculation, Ed. K
Messmer and WM Kbler, Monduzzi Editore, Bologna, Italy, pp421-425, 1996
156.

Tanahashi N, Fukuuchi Y, Tomita M, Kobari M, Takeda H, Yokoyama M, Terakawa S:

White thrombus formation: Observations by VEC-DIC microscopy. In: Microcirculation Annual
1996 M Tsuchiya, M Asano and N Tsushima, Eds., Nihon-Igakukan, Tokyo, 24-25, 1996
157.

Tomita M, Fukuuchi Y, Tanahashi N, Takeda H, Yokoyama M, Haapaniemi H. Disruptionof membranous monolayers of cultured pig and rat brain endothelial cells induced by activatedhuman polymorphonuclear leukocytes. In: Biology and Physiology of the Blood-Brain Barrier,edited by PO Courud, and Scherman, Plenum Press, New York, 1996, pp 253-261
158.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Konno S, Yokoyama M:

Microglial cell death following phagocytosis of zymosan-A under a VEC-DIC microscope: does
this include apoptosis? In: Maturation Phenomenon in Cerebral Ischemia II. Neural Recovery
and Plasticity. Itoh U, Kirino T, Kuroiwa T, Klatzo I Eds., Springer-Verlag, Berlin-Heidelberg,
New York, 1997, pp. 197-203
159.

Tanahashi N, Fukuuchi Y, Tomita M, Takeda H, Yokoyama M, Itoh Y, Itoh D: Platelet

adhesion to thrombin-treated endothelial cells in vitro - observation by VEC-DIC microscopy -.
Microcirc ann 13: 109-110, 1997
160.

Takeda H, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Yokoyama M, Takao M, Ito

D: Enhanced lamellipodtal ruffling and vacuolization of microglia by hydrogen peroxide. J
Cereb Blood Flow and Metab 17 (Suppl): S673, 1997
161.

Yokoyama M, Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Takao M, Ito

D: Vulnerability of phagocytic microglia to ultraviolet light as observed by VEC-DIC
microscopy. J Cereb Blood Flow and Metab 17 (suppl): S720,1997
162.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Takao M, Yokoyama M, Ito

D: Glutamate-induced cultured astrocytic swelling, depolarization and lonic changes. J Cereb
Blood Flow and Metab 17 (Suppl): S730,1997
163.

Takeda H, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M, Yokoyama M, Takao M, Ito

D: Hydrogen peroxide enhances lamellipodial ruffling and vacuolization of ameboid microglia.
Neurosci Lett. 240: 5-8, 1998
164.

Tomita M, Tanahashi N, Takeda H, Yokoyama M, Fukuuchi Y: Erythrocyte flickering

22as observed by high speed VEC-DIC microscopy. Proceedings for 8th European
Microcirculation, K Messmer et al., Eds., Monduzzi Editore, Bologna, Italy, 1998, pp 225-228
165.

Tomita M, Fukuuchi Y, Tanahashi N, Kobari M, Takeda H, Yokoyama M: Lowering of

ameboid microglial resistance to hydrogen peroxide by propentofylline. In Maturation
Phenomenon in Cerebral Ischemia III. Eds. Ito U. and Klatzo I., Springer, pp. 151-157, 1998
166.

Tomita M, Amano T, Tanahashi N, Inoue K, Schiszler I, Fukuuchi Y: Flow responses tolocal stimulus by penicilin-G with time and in space in the cerebral cortex. K Messmer et al.,
Eds., Monduzzi Editore, Bologna, Italy, 201-205, 1998
167.

Tomita M, Tanahashi N, Kobari M, Yokoyama M, Inoue M, Schiszler I, Fukuuchi Y:

Oxygen and hydrogen gas transport through living C6 cell suspensions is faster than that in deadcells. A. Eke, D. T. Delpy, Eds., Plenum, New York, pp 741-747, 1999
168.

Tomita M, Fukuuchi Y, Tanahashi N, Takeda H: Changes in resistance of cultured

microglia to hydrogen peroxide with differentiation. Microcirc Ann 14: 17-18, 1998
169.

Tanahashi N, Fukuuchi Y, Tomita M, Itoh Y, Itoh D, Tomita Y, Inoue K, Schiszler I:

Fibrin formation and fibrinolysis by tissue plasminogen activator in vitro - Observation by
VEC-DIC microscopy-. Microcirc Ann 14: 47-48, 1998
170.

Inoue K, Fukuuchi Y, Tomita M, Tanahashi N, Kobari M: Zeiosis of cultured huvec

induced by PAF and trypsin. Microcirc Ann 14: 57-58, 1998
171.

Tanahashi N, Fukuuchi Y, Tomita M, Yokoyama M, Tomita Y, Inoue K, Schiszler I:

Effect of argatroban and heparin on adhesion of activated platelets to human brain microvascularendothelial cells in vitro. Observation by vecdic microscopy (abstr). J CBF and Metab 19 (Suppl.
1): S252, 1999
172.

Tanahashi N, Fukuuchi Y, Tomita M, Inoue K, Satoh H, Abe T. Role of platelet

glycoprotein IIb/IIIa in platelet adhesion to thrombin treated human brain microvascularendothelial cells in vitro. Observation with video-enhanced contrast microscopy. J Cereb Blood
Flow Metabol 21 (Suppl. 1): S215, 2001
173.

Inoue K, Tomita M, Tanahashi N, Fukuuchi Y. Fissure-network formation and lysis ofcultured human brain endothelial cell membranes induced by blowing on the medium surface. J
Cereb Blood Flow Metabol 21 (Suppl. 1): S135, 2001
174.

Tanahashi N, Fukuuchi Y, Tomita M, Yokoyama M, Tomita Y, Inoue K, Schiszler I.

Selective thrombin inhibitor (Argatroban): Amelioration of platelet adhesion to human brain
microvascular endothelial cells in vitro: Observation with video-enhances contrast microscopy.
In: Ischemic Blood Flow in the Brain. Y. Fukuuchi, M. Tomita, A. Koto, Eds., Keio University
Symposia for Life Science and Medicine, Volume 6, Springer, Tokyo-Berlin-Heidelberg, 2001,
pp 413-419.

VI．１９７０年以前の業績

23

175.

Meyer JS, Gotoh F, Ebihara S, Tomita M: Effects of anoxia on cerebral metabolism andelectrolytes in man. Neurology 15:892-901, 1965
176.

Aizawa T, Muramatsu F, Hamaguchi K, Tomita M, Kakimi R, Toyoda M: Cerebral

circulation, metabolism and electrical activity during convulsion induced by megimide. Jpn Circ
J 29:449-454, 1965
177.

Meyer JS, Gotoh F, Tomita M, Akiyama M: New technics for recording cerebral bloodflow and metabolism in subjects with cerebrovascular disease. In Cerebral Vascular Disaese.
Grune & Stratton, pp147-166, 1966
178.

Gotoh F, Meyer JS, Tomita M: Carbonic anhydrase inhibition and cerebral venous bloodgases and ions in man. Arch Int Med 117:39-46, 1966
179.

Meyer JS, Gotoh F, Tomita M, Akiyama M: Automatic recording of cerebral blood flowby the nitrous oxide method without blood loss. Neurology 16:305, 1966
180.

Meyer JS, Gotoh F, Tomita M: Acute respiratory acidemia. Correlation of jugular blood

composition and electroencephalogram during CO2 nacrosis. Neurology 16:463-474, 1966
181.

Meyer JS, Gotoh F, Tomita M: Cerebral metabolism during arousal and mental activity instroke subjects. J Am Ger Soc 14:986-1012, 1966
182.

Gotoh F, Meyer JS, Tomita M, Akiyama M: The hydrogen method for recording cerebral

blood flow. Tr Am Neurol Ass:80-83, 1966
183.

Gotoh F, Meyer JS, Tomita M: Hydrogen method for determining cerebral blood flow inman. Arch Neurol 15:549-559, 1966
184.

Aizawa T, Muramatsu F, Hamaguchi K, Tomita M, Kakimi R, Toyoda M: Study of thecerebral circulation, metabolism and electrical activity. Effects of chlordiazepoxide in thenormal and convulsive cats. Jpn Circ J 30:13-20, 1966
185.

Tomita M, Meyer JS, Gotoh F: Desaturation of hydrogen gas from human brain after

inhalation.

In Research on the Cerebral Circulation, Meyer JS et al (Eds.) Thomas Publ.,

Springfield, Ill, pp145-172, 196924

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