Contractile dysfunction in congestive heart failurewww.abcam.com

Catecholamine

Forward
ModeCa2+

Cell Membrane
αCytoplasm

Adenyl Cyclase
PP
GRKβ Arrestin

L-TypeCalcium Channel

Sodium/Calcium
Exchanger

β Adrenergic Receptor

ReverseMode Ca2+cAMP

PKA

PKA
PPP

Key & Abbreviations:

PCa2+

Indicates activation
Indicates desensitization/functional blockade
Indicates movement of Ca2+
Indicates phosphorylation
Indicates facilitationcAMP Cyclic Adenosine Monophosphate
CAMKII Calcium/Calmodulin Kinase IIGRKG Protein-Coupled Receptor Kinase
PKAProtein Kinase APLB
PhospholambanRYR
Ryanodine Receptor
SERCA Sarcoplasmic Reticulum Calcium ATPase

Ca2+P

FK506Binding Protein

RYR

Troponin CTriadin

Sarcoplasmic
Reticulum

JunctinCalsequestrin 2Ca2+

Contractile Myofilaments

SERCA

Sarcolipin

PKA
Copyright © 2011 Abcam, All Rights Reserved. Produced in collaboration with Dr. Kalpana Vijayan.

Ca2+

PLB

PP

CAMKIIHeart failure related products from Abcam:
Product

Clonality Applications

Host Species
Reactivity

Datasheetwww.abcam.com/ab…

www.abcam.com

Proteins

alpha 1 Adrenergic Receptor

PICC/IF, WB

Rb

Hu, Ms, Rat, Dm, Zfsh3462

alpha 1 Adrenergic Receptor

M

WB

Ms

Hu

54730

-

alpha 2a Adrenergic Receptor P

ICC/IF, IHC-P, WB

Rb

Hu, Ms, Rat

65833

54291

beta 2 Adrenergic Receptor

P

ICC, ICC/IF, WB

Chk Hu, Rat

13989

-

beta 2 Adrenergic Receptor

P

Flow Cyt, ICC/IF, WB

Rb

Hu, Ms, Rat

36956

--

CACNA1SP

IHC-P, WB

Rb

Hu

96413

-

CACNA1S [1A]

M

IHC-Fr, IP, WB

Ms

Hu, Ms, Rat, Gpig, Rb, Zfsh

2862

-Calsequestrin

P

IHC-P, IP, WB

Rb

Dog, Hu, Ms, Rtrout, Rat, Shp 3516

Calsequestrin 2PIHC-P, WB

Rb

Hu

96387

93736

CaMKII alphaM

ICC/IF, IP, WB

Ms

Hu

54925

60899

CaMKII alpha (phospho T286)

P

ICC/IF, IHC (PFA fixed), IHC-Fr, WB

Rb

Hu, Rat, Rb

5683-cardiac Troponin C [1A2]

M

AP, ELISA, IHC-P, sELISA, WB

Ms

Hu

8285

9932

Cardiac Troponin I

P

ICC/IF, IHC-P, WB

Rb

Hu, Ms, Pig

47003

9936

Cardiac Troponin I [284 (19C7)] M

AP, ELISA, ICC/IF, IHC-FoFr, IHC-P, WB

Ms

Hu, Ms, Rat, Cat, Cow, Dog,Fsh, Goat, Mk, Pig, Rb

19615

-

cardiac Troponin T

P

ICC/IF, WB

Rb

45932

9937

cardiac Troponin T [1F11]

M

AP, ELISA, ICC, ICC/IF, WB

Ms

Fsh, Goat, Pig, Rb

10214

-

Hu
Hu, Ms, Rat, Cat, Cow, Dog,M

IHC-Fr, IHC-P, IP, WB

Ms

Hu, Ms, Rat

84814

-

FKBP1BPELISA, WB

Rb

Hu, Ms82316-

NCX1 [C2C12]M

ICC/IF, IF, IHC-P, IP, WB

Ms

Hu, Rat, Dog, Gpig, Rb

2869-IHC-Fr, WB

Rb

Hu, Ms, Rat, ChHm, Cow,15000-

Rb, Shp

2865-59225-Rb, Shp

2868-Hm, Rb
Phospholamban [2D12]M

ICC/IF, IHC-P, IP, WB

Ms

beta 2 Adrenergic Receptor (ab36956)
Clonality Applications
P
Flow Cyt, ICC/IF, WB

Host
Rb

Species cross reactivity
Hu, Ms, Rat-DHPR alpha 1 [S57-46]

Phospholamban (phospho S16) P

Featured antibodies

Phospholamban (phospho S16) (ab15000)
Clonality Applications
P
IHC-Fr, WB

HostRbSpecies cross reactivity
Hu, Ms, Rat, ChHm, Cow,Hm, RbHostRb

Species cross reactivity
Hu

Cardiac Troponin T (ab45932)
Clonality ApplicationsP
ICC/IF, WB

DHPR alpha 1 [S57-46] (ab84814)

Hu, Ms, Rat, Dog, Gpig, Pig,

Clonality Applications
M
IHC-Fr, IHC-P, IP, WB

Host
Ms

Species cross reactivity
Hu, Ms, Rat

Ryanodine Receptor
P

ELISA, IHC-P

Rb

Hu, MsRyanodine Receptor [34C]

M

ICC/IF, IHC-Fr, IHC-P, IP, WB

Ms

Hu, Ms, Rat, Cow, Dog,

Sarcolipin/SLN

Ryanodine Receptor [34C] (ab2868)

P

N/ARb

Fast track

25860-SERCA2 ATPaseP

ICC/IF, IHC-P, WB

Rb

Hu77289-SERCA2 ATPase [2A7-A1]

M

ICC/IF, IHC-Fr, IHC-P, IP, WB

Ms

Hu, Ms, Rat, Dog, Gpig, Rb

2861-Clonality Applications
M
ICC/IF, IHC-Fr, IHC-P, IP, WB

Host
Ms

Species cross reactivity
Hu, Ms, Rat, Cow, Dog,Rb, Shp

081-09/09-PW(phospho S2808)