This is what a fish thought looks like

13/02/12 23:54

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Science NewsJan. 31, 2013 — For the first time, researchers
have been able to see a thought "swim" throughthe brain of a living fish. The new technology is a
useful tool for studies of perception. It might evenfind use in psychiatric drug discovery, according toauthors of the study, appearing online on January
31 in Current Biology.

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The technical breakthrough included
the development of a very sensitive
fluorescent probe to detect neuronal
activity. Kawakami, along with
Junichi Nakai of Saitama Universityand their colleagues, also devised a
genetic method for inserting thatprobe right into the neurons ofinterest. The two-part approachallowed the researchers to detect
neuronal activity at single-cellresolution in the zebrafish brain.

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Akira Muto, the study's lead author
from the Kawakami lab, used thenew tool to map what happens
when a zebrafish sees something
good to eat, in this case aswimming paramecium. The
researchers were also able tocorrelate brain activity with thatprey's capture.
The new tool now makes it possible
to ask which brain circuits are
involved in complex behaviors, fromperception to movement to decision
making, the researchers say, notingthat the basic design and function ofa zebrafish brain is very much likeour own.
"In the future, we can interpret an animal's behavior, including
learning and memory, fear, joy, or anger, based on theactivity of particular combinations of neurons," Kawakami said.
By monitoring neuronal activity in the zebrafish brain,
Kawakami thinks that researchers may also be able to screen
chemicals that affect neuronal activity in the brain. "This has
the potential to shorten the long processes for thedevelopment of new psychiatric medications," he said.
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Story Source:
The above story is reprinted from materials provided by
Cell Press, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For
further information, please contact the source cited above.
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がん免疫療法をご希望の方へ"Our work is the first to show brain
activities in real time in an intact
animal during that animal's natural
behavior," said Koichi Kawakami ofJapan's National Institute ofGenetics. "We can make theinvisible visible; that's what is mostimportant."

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This Is What a Fish Thought Looks Like

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For the first time, researchers have been able tosee a thought "swim" through the brain of a living
fish. The new technology is a useful tool forstudies of perception. It might even find use inpsychiatric drug discovery, according to authors ofthe study, appearing online on Jan. 31 in Current
Biology, a Cell Press publication. (Credit: CurrentBiology, Muto et al.)Ads by Google

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This is what a fish thought looks like

1. Akira Muto, Masamichi Ohkura, Gembu Abe, Junichi
Nakai, Koichi Kawakami. Real-Time Visualization ofNeuronal Activity during Perception. Current Biology,
2013; DOI: 10.1016/j.cub.2012.12.040
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Cell Press (2013, January 31). This is what afish thought looks like. ScienceDaily. Retrieved
February 12, 2013, fromhttp://www.sciencedaily.com/releases/2013/01/130131144419.htm

13/02/12 23:54
Hunters or Slackers (Aug. 4, 2010) — Whether afish likes to hunt down its food or wait for dinner toarrive is linked to the composition of its ... > readmore
Water Movements Can Shape Fish
Evolution (Feb. 4, 2010) —Researchers have found that thehydrodynamic environment of fish canshape their physical form and swimming ... > readmore
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