CURRICULUM VITAESEYLAZ Jacques
Present position :Emeritus Director of Research (exceptional class) CNRS(Centre National de la Recherche Scientifique)

Date and place of Birth :February 17, 1939, Neuchâtel (Switzerland)

Nationality :Degrees :Swiss and French
Master of Science (Physics), Neuchâtel, Switzerland, 1961
Diploma in Physics, Neuchâtel, Switzerland, 1962
Doctor of Sciences (Physiology), Paris, France, 1966.

PROFESSIONAL EXPERIENCE :1962-1964

Research fellow (first degree), Swiss National Scientific Research Foundation

1965-1966

Research fellow (second degree), Swiss National Scientific Research
Foundation

1966-1967

Research fellow (first degree), INSERM (Institut National de la Santé et de laRecherche Médicale)

1968-1974

Research fellow (second degree), CNRS (Centre National de la Recherche
Scientifique)

1974-1984

Master of Research, CNRS

1985- 1991

Director of Research, CNRS

since 1991

Director of research (exceptional class ), CNRSAPPOINTMENTS :1973-1978

Head of research coordination program 319 CNRS, (in collaboration with theHistology Department of University of Lund, Sweden : Professor OWMAN).

1977-1978

Head of the Laboratory of Human Physiology, ERA 361 CNRS (co-direction
with Professor MAMO).

1977-1978

Head of research laboratory F.R.A. 17 INSERM

1978-1990

Head of the Laboratory of Cerebrovascular Physiology and Pathophysiology, U
182 INSERM, URA 641 CNRS.

1990-1997

Head of the Cerebrovascular Research Laboratory, URA 641 CNRS.

1997-2000

Head of the Cerebrovascular Research Laboratory, UPR 646 CNRS.

2000-2002
2004

Head of the Cerebrovascular Research Laboratory, FRE 2363 CNRS
Emeritus Director of Research (exceptional class) CNRSTEACHING (Medical and scientific undergraduate) :University Paris VI. Neurophysiology
University Paris V. Pharmacology
University Paris VI. Neurosciences
ACTIVITIES IN SCIENTIFIC COMMITTEES :- Member, School of Medicine Lariboisière-Saint-Louis Council (1975-1981 and 1989-1993)- Member, Section 29 (Physiology) of the National Scientific Committee CNRS (1972-1976)- Member, Instrumental Biomedical Committee for Advanced Research (1982-1986)- Member, Medical and Biological Engineering Club (CNRS) (1982-1984)- Member, Section 27 ("Pharmacology and Experimental Therapy") of the National ScientificCommittee, CNRS (1983-1986)- President, Section 46 (Interdisciplinary Committee for Industrial Relations) of the National
Scientific Committee, CNRS (1983-1991)- President, Space Life Sciences Committee, CNES (Centre National d'Etudes Spatiales) (19852000)- Director, International Society "Cerebral Blood Flow and Metabolism" (1983-1989 and 19911995)- Member, Executive Committee, French Society for Cerebral Blood Flow and Metabolism(1984-1990)- President, Executive Committee, French Society for Cerebral Blood Flow and Metabolism(1987-1989)- Member, National Committee for UNESCO (1990-1996)- Member, Commission on Gravitational Physiology : International Union of Physiological
Sciences (since 1990). President since 1993.
- Member, National Consultation on Ethics Committee (CCNE) (1990-1998).
- Co-director of Department of Life Science, Headquarters CNRS (1995-2000).

PUBLICATIONS :Author of more than 200 publications in journals such as :Neuroscience, Am. J. Physiol., J. Cereb. Blood Flow Metabol., Brain Res., J. Neurochem.,
Blood Vessels, Pflüg. Arch., Stroke, J. Appl. Physiol., E.E.G. Clin. Neurophysiol., Acta Neurol.,
Neurology, Acta Neurol. Scand., Med. Prog. Technol., Med. and Biol. Eng. and Comput., Acta
Physiol. Scand., Europ. J. Pharmac., Brit. J. Pharmac., Brain Research Reviews, Med. Progr.
Technol.
THESES :Responsible for 31 theses.

REFEREE FOR PUBLICATIONS :Journal of Cerebral Blood Flow and Metabolism ; Brain Research ; Blood Vessels ;Neurology ; Cephalalgia ; European Journal of Physiology ; Experimental Brain
Research ;E.E.G. and Clinical Neurophysiology ; Neuroscience Letters ;Neuropsychologia ; Circulation Research ; Vascular Research ; Journal de Circulation etMétabolisme du Cerveau

INTERNATIONAL MEETINGS (invited speaker or chairman)
Pharmakologie der localen Gehirndurchblutung, Bonn, R.F.A., 1969.
Seventh Symposium Neuroradiologium, Paris, France, 1970.
Fourth International Symposium on the Regulation of Rerebral Blood Flow. London, U.K., 1970.
Fifth International Symposium on the Regulation of Cerebral Blood Flow. Roma, Italie, 1971.
Rencontre Franco-Québecoise - Physiopathologie Pulmonaire en Anesthésiologie. Montpellier,France, 1972.
Journées Internationales de Circulation Cérébrale. Toulouse, France, 1972.
Congrès de la Société Neurologique et Psychiatrique Hongroise. Budapest, Hongrie, 1972.
Sixth International Cerebral Blood Flow Symposium. Philadelphia, U.S.A., 1973.

Symposium International de Neuro-radiologie. Capri, Italie, 1973.
Alfred Benzon Symposium: the Working Brain. Copenhaguen, Danemark, 1974.
Sixth Salzburg Conference on Cerebral Vascular Disease. Salzburg, R.F.A., 1974.
Seventh International Cerebral Bood Flow Symposium. Aviemore, U.K., 1975.
Eighth International Symposium on Cerebral Blood Flow and Metabolism. Copenhaguen,
Danemark, 1977.
International Symposium on Neurogenic Control of the Brain Circulation. Stockholm, Suède,
1977.
27ème Congrès International des Sciences Physiologiques. Paris, France, 1977.
Colloque International sur les Signaux et les Images en Médecine et en Biologie. Paris, France,
1978.
28ème Congrès de Neuro-chirurgie de langue française. Athènes, Grèce, 1978.
Second International Symposium on Quantitative Mass Spectrometry in Life Sciences. Gent,
Belgique, 1978.
Congrès International de Circulation Cérébrale. Toulouse, France, 1979.
Symposium International Beta-bloquant. Paris, France, 1979.
Congrès International "Deoxyglucose Uptake and Oxygen Consumption". Paris, France, 1980.
Tenth International Symposium on Cerebral Blood Flow and Metabolism. Saint Louis, Missouri,
U.S.A., 1981.
Symposium on Cerebral Blood Flow - Effect of Nerves and Neurotransmitters. Iowa, U.S.A., 1981.
XXth European Conference on Microcirculation. Jérusalem, Israel, 1982.
European Society for Neurochemistry and World Federation of Neurology. Rome, Italie, 1982.
Eleventh International Symposium on Cerebral Blood Flow and Metabolism. Paris, France, 1983.
Neurotransmitters and the Cerebral Circulation. Paris, France, 1983.
International Symposium on Cerebral Blood Flow, Metabolism and Epilepsy. Montpellier, France,
1983.
Effects of Ageing on Regulation of Cerebral Blood Flow and Metabolism. San Remo, Italie, 1983.
Réunion Franco-Allemande de Pharmacologie. Freiburg, R.F.A., 1983.
Symposium on Measurement of Cerebral Blood Flow and Cerebral Metabolism in Man.
Heidelberg, R.F.A., 1983.
Neuroscience Meeting. Anaheim, U.S.A., 1984.

XIIth International Symposium on Cerebral Blood Flow and Metabolism. Lund/Rönneby, Suède,
1985.
Neural Regulation of Brain Circulation. Lund/Orenas, Suède, 1985.
Acute Brain Ischemia. Sienne, Italie, 1985.
Neuroscience Meeting. Dallas, U.S.A., 1985.
10th Annual Meeting of the European Neuroscience Association. Marseille, France, 1986.
XIIIth International Symposium on Cerebral Blood Flow and Metabolism. Montréal, Canada,
1987.
2nd International Symposium on Pharmacology of Cerebral Ischemia. Marburg, R.F.A., 1988.
8th European Winter Conference on Brain Research. Tignes, France, 1988.
V° Congrès International de Circulation Cérébrale. Toulouse, France, 1989.
XIVth International Symposium on Cerebral Blood FLow and Metabolism. Bologne, Italie, 1989.
Neurotransmission and Cerebrovascular Function. La Napoule, France, 1989.
3rd International Symposium on Pharmacology of Cerebral Ischemia. Marburg, R.F.A., 1990.
Congrès "Ischémie Cérébrale", Istambul, Turquie, 1990.
XVth International Symposium on Cerebral Blood Flow and Metabolism, Miami, USA, 1991.
The Role of Neurotransmitters in Brain Injury, Key West, USA, 1991.
1er Colloque de la Société des Neurosciences, Strasbourg, 1992.
International Symposium on Pharmacology of Cerebral Ischemia, Marburg, Allemagne, 1992.
14th Annual Meeting, IUPS Commision of Gravitational Physiology, 1992.
XVIth International Symposium on Cerebral Blood Flow and Metabolism, Sendai, Japon, 1993.
International Symposium on Cerebral Blood Vessel, Mount Zao, Japon, 1993.
5e Symposium Européen sur les Sciences de la Vie dans l'Espace. Arcachon, 1993.
International Symposium on Heavy Ions, Sophia-Antipolis, 1993.
5th International Symposium on Pharmacology of Cerebral Ischemia, Marburg, Allemagne, 1994.
16th Annual International Gravitational Physiology Meeting, Reno, USA, 1995.
11th Man in Space Symposium, Toulouse, 1995.
2e Colloque de la Société des Neurosciences, Lyon, 1995.
XVIIth International Symposium on Cerebral Blood Flow and Metabolism, Köln, Allemagne,
1995.

17th Annual Gravitational Physiology Meeting, Varsaw, Pologne, 1996. 12th Man in Space
Symposium, Washington, USA,1997.
Brain 97 : 18th International Symposium on Cerebral Blood Flow and Metabolism, Baltimore,
USA, 1997.
Mechanisms of Cerebrovascular Functions and Regulation, Williamsburg, USA, 1997.
XXXIIIth International Congress of Physiological Sciences (Symposium Space Physiology),
Saint-Pétersbourg, Russie, 1997.
XIXth Annual Meeting of the International Society for Gravitational Physiology, Rome, Italy,
1998.
Brain 99. XIXth International Symposium of Cerebral Blood Flow, Metabolism and Function.
Copenhague, Danemark, 1999.
Ischemic Blood Flow in the Brain, Tokyo, Japan, 1999.
Brain Activation and Cerebral Blood Flow Control. Tokyo, Japan, 2001.
XXth International Symposium on Cerebral Blood Flow and Metabolism. Taipei, Taiwan, 2001

PRINCIPAL PUBLICATIONSGRUEBLER W., SEYLAZ J. et ROSSEL J. Mesure du 1er niveau excité du Na21 à l'aide
d'une coïncidence neutron-gamma. Helv. Physico. Acta, 1962, 35, 284-287.
SEYLAZ J. Essais d'analyse de l'électroencéphalogramme par traduction auditive. C.R. Acad.
Sc. Paris, 1963, 257, 966-968.
SEYLAZ J. Mesure instantanée des petites variations de flux sanguin parcourant un tissu "invivo". J. Physiol., 1964, 56, 441-442.
MOLNAR L. et SEYLAZ J. Clinical experiences in brain disorders. Acta Convent. Neuropsy.
and E.E.G. Hungaria, 1965, 25, 77-80.
MOLNAR L. et SEYLAZ J. Mise en évidence et interprétation des effets de la décérébration
et des sinus carotidiens sur la circulation cérébrale. C.R. Acad. Sc., 1965, 260, 3164-3167.
SEYLAZ J. Développement d'une méthode de mesure instantanée, localisée et semiquantitative du débit sanguin "in vivo". Applications diverses. Biophysik, 1965, 2, 330-339.
SEYLAZ J. et MOLNAR L. Nouvelle technique pour l'enregistrement synchrone du débit
sanguin et de l'activité électrique du cerveau chez les animaux vigiles. C.R. Soc. Biol., 1965,
160, 268-262.
SEYLAZ J. et MOLNAR L. Observations récentes sur les corrélations entre le débit cérébral
et la dépression envahissante. C.R. Soc. Biol., 1965, 160, 294-298.
SEYLAZ J. et MOLNAR L. A study of the control of cerebral blood flow in the freely
moving rabbit. Arch. Ital. Biol., 1968, 106, 157-164.
SEYLAZ J., MOLNAR L. et NEVERLEE H. Quelques corrélations entre le potentiel stable(steady potential) cortical et la circulation sanguine cérébrale. J. Physiol., 1968, 57, 701.
GOAS J.Y., SEYLAZ J., MAMO H., MAC LEOD P., CARON J.P. et HOUDART R.
Variations du débit sanguin du cortex de l'homme au cours du sommeil. Rev. Neurol., 1969,
120, 159-176.
MAMO H., FRANCHI P., MARTIN A., SEYLAZ J. et HOUDART R. Tomographies
acoustiques des processus expansifs intracrâniens. Résultats préliminaires obtenus chezl'adulte par un appareillage expérimental. J. Neurol. Sci., 1969, 9, 63-76.
SEYLAZ J., MAMO H., CARON J.P., MAC LEOD P. et HOUDART R. Contribution àl'étude des sténoses carotidiennes dans l'insuffisance circulatoire cérébrale. J. Neuro-Chir.,1969, 15, S.2, 83-102.
MAMO H., SEYLAZ J., REY A. et HOUDART R. Etude pharmacodynamique du débit
sanguin du cortex de l'homme par une méthode de mesure continue et focale. Rev. Neurol.,1970, 123, 101-115.
MAMO H. et SEYLAZ J. Conception générale sur la physio-pathologie des accidentsischémiques du cerveau d'origine athéromateuse. Rev. Prat., 1970, 8, 419-425.
SEYLAZ J., MAMO H., GOAS J.Y., MAC LEOD P., CARON J.P. et HOUDART R. Local
cortical blood flow during paradoxical sleep in man. Arch. Ital. Biol., 1971, 109, 1-14.
MAMO H. et SEYLAZ J. Contribution à l'étude de la physiologie et de la physiopathologie
de la circulation cérébrale de l'homme. Act. Neurophysiol., 1971, 9, 191-216.

MAMO H., SEYLAZ J., REY A. et HOUDART R. A pathophysiological approach to thealtered CO2 effect on cerebral blood flow in post acute ischaemia in man. Europ. Neurol.,1972, 6, 306-312.
SEYLAZ J., AUBINEAU P.F., CORREZE J.L. et MAMO H. Techniques for continuous
measurement of local cerebral blood flow, PaO2, PaCO2 and blood pressure in the nonanaesthetized animal. Pflüg. Arch., 1973, 340, 175-180.
AUBINEAU P.F., SEYLAZ J., SERCOMBE R. et MAMO H. Evidence for regional
differences in the effect of beta-adrenergic stimulation on cerebral blood flow. Brain
Research, 1973, 61, 153-161.
SEYLAZ J., AUBINEAU P., EDVINSSON L., MAMO H., NIELSEN K.C., OWMAN Ch.
et SERCOMBE R. Regional differences in beta-adrenergic effects on local cerebral bloodflow and in sympathetic vascular innervation. Stroke, 1973, 4, 369-370.
SEYLAZ J., CORREZE J.L., PINARD E., LUFT A. et MAMO H. Mesure continue de la
PaO2 et de la PaCO2 par spectrographie de masse. Ann. Anesth. Franc., 1973, 14, 109-112.
AUBINEAU P.F., SEYLAZ J., MAMO H., SERCOMBE R., LUFT A., PINARD E.,
NIELSEN K.C., OWMAN Ch. et EDVINSSON L. Données expérimentales sur lesmécanismes de la régulation du débit sanguin cérébral. Rev. Neurol., 1973, 129, 349-358.
SEYLAZ J., PINARD E., CORREZE J.L., AUBINEAU P.F. et MAMO H. Quantitative
continuous measurement of blood gas tensions by mass spectrometry. J. Appl. Physiol., 1974,
37, 937-941.
MAMO H. et SEYLAZ J. La circulation cérébrale. Aspects méthodologiques etphysiologiques. Rev. E.E.G. Neurophysiol. Clin., 1974, 4, 194-200.
MAMO H., SEYLAZ J., CORREZE J.L., PINARD E. et REY A. Contrôle continu du débit
sanguin cérébral et de ses variables. Applications à la chirurgie carotidienne. Acta Neurol.,1974, 24, 108-116.
EDVINSSON L., AUBINEAU P.F., OWMAN Ch., SERCOMBE R. et SEYLAZ J.
Sympathetic innervation of cerebral arteries: Prejunctional supersensitivity to Norepinephrine
after sympathectomy or Cocaïne treatment. Stroke, 1975, 6, 525-530.
SERCOMBE R., AUBINEAU P., EDVINSSON L., MAMO H., OWMAN Ch., PINARD E.
et SEYLAZ J. Neurogenic influence on local cerebral blood flow: Effect of catecholaminesor sympathetic stimulation as correlated with the sympathetic innervation. Neurology, 1975,
25, 954-963.
LACOMBE P., REYNIER-REBUFFEL A-M., MAMO H. et SEYLAZ J. Quantitative
multiregional blood flow measurements during cervical sympathetic stimulation. Brain
Research, 1977, 129, 129-140.
LACOMBE P., SERCOMBE R., REYNIER-REBUFFEL A-M., LUSAMVUKU N.,
PINARD E. et SEYLAZ J. Time course of the effects of cervical sympathetic stimulation on
local CBF: evidence for an escape phenomenon. Acta Neurol. Scand., 1977, 56, 40-41.
MERIC Ph. et SEYLAZ J. Radiation scattering and the determination of regional cerebral
blood flow by radioisotope clearance. Med. Prog. Technol., 1977, 5, 41-46.
MERIC Ph., SEYLAZ J., LUFT A., CORREZE J.L. et MAMO H. Measurement of regional
cerebral blood flow by intravenous injection of Xe 133. Acta Neurol. Scand., 1977, 56, 462463.
SEYLAZ J. et PINARD E. Continuous intracerebral PO2 and PCO2 measurements by mass
spectrometry. Study of the influence of vasoactive drugs. Acta Neurol. Scand., 1977, 56, 438439.

SERCOMBE R., AUBINEAU P., EDVINSSON L., MAMO H., OWMAN Ch. et SEYLAZ J.
Pharmacological evidence "in vitro" and "in vivo" for functional ß1 receptors of cerebral
circulation. Pflüg. Arch., 1977, 368, 241-244.
PINARD E., SEYLAZ J. et MAMO H. Quantitative continuous measurement of PO2 andPCO2 in artery and vein. Med. and Biol. Eng. and Comput., 1978, 16, 59-64.
SEYLAZ J. et PINARD E. Continuous measurement of gas partial pressures in intracerebral
tissue. J. Appl. Physiol., 1978, 44, 528-533.
PINARD E. et SEYLAZ J. Intracerebral gas partial pressures changes under vasoactive
drugs: a mass spectrometry study. Pflüg. Arch., 1978, 375, 25-30.
PINARD E., SEYLAZ J. et MAMO H. Effects de drogues vaso-actives sur les gaz tissulaires
cérébraux. Etude expérimentale par spectrométrie de masse. Rev. Neurol., 1978, 134, 133140.
SERCOMBE R., LACOMBE P., AUBINEAU P., MAMO H., PINARD E., REYNIERREBUFFEL A-M. et SEYLAZ J. Is there an active mechanism limiting the influence of thesympathetic system on the cerebral vascular bed? Evidence for vasomotor escape from
sympathetic stimulation in the rabbit. Brain Research, 1979, 164, 81-102.
SEYLAZ J., PINARD E., DITTMAR A. et BIRER A. Measurement of blood flow, tissue
PO2 and tissue PCO2 continuously and simultaneously in the same structure of the brain.
Med. and Biol. Eng. and Comput., 1979, 17, 19-24.
PINARD E., PURVES M.J. SEYLAZ J. et VASQUEZ J. The dilator pathway to cerebral
blood vessels. Pflüg. Arch., 1979, 379, 165-182.
LACOMBE P., MERIC P., REYNIER-REBUFFEL A-M. et SEYLAZ J. Critical evaluationof cerebral blood flow measurements made with 14C-ethanol. Med. and Biol. eng. andComput., 1979, 17, 126-142.
MERIC P., SEYLAZ J., CORREZE J.L., LUFT A. et MAMO H. Measurement of regional
cerebral blood flow by intravenous injection of Xe 133. Med. Prog. Technol., 1979, 6, 53-63.
EDVINSSON L., LACOMBE P., OWMAN Ch., REYNIER-REBUFFEL A-M. et SEYLAZ
J. Quantitative changes in regional Cerebral Blood Flow of rats induced by alpha and betaAdrenergic stimulants. Acta Physiol. Scand., 1979, 107, 289-296.
LUSAMVUKU N.A.T., SERCOMBE R., AUBINEAU P. et SEYLAZ J. Correlated
electrical and mechanical responses of isolated rabbit pial arteries to some vasoactive drugs.
Stroke, 1979, 10, 727-732.
REYNIER-REBUFFEL A-M., LACOMBE P., AUBINEAU P., SERCOMBE R. et SEYLAZ
J. Multiregional cerebral blood flow changes induced by a cholinomimetic drug. Europ. J.
Pharmac., 1979, 60, 237-240.
SEYLAZ J., MERIC P., CORREZE J.L., LUFT A. et MAMO H. Analytical problems
associated with the non invasive measurements of cerebral blood flow in cerebrovasculardiseases. Med. and Biol. Eng. and Comput., 1980, 18, 39-47.
AUBINEAU P., SERCOMBE R. et SEYLAZ J. Parasympathomimetic influence of
carbachol on local cerebral blood flow in the rabbit by a direct vasodilator action and an
inhibition of the sympathetic-mediated vasoconstriction. Brit. J. Pharmac., 1980, 68, 449-459.
LACOMBE P., MERIC P. et SEYLAZ J. Validity of cerebral blood flow measurements
obtained with quantitative techniques. Brain Research Reviews, 1980, 2, 105-169.

MERIC P., BRONNER B., CORREZE J.L. et SEYLAZ J. Stability of gamma ray detectors
and measurement of blood flow by isotope clearance. Med. Progr. Technol., 1980, 8, 57-64.
PINARD E. et SEYLAZ J. Continuous estimation of cerebral metabolic changes. Eur.
Neurol., 1981, 20, 225-229.
OUDART N., SERCOMBE R., AUBINEAU P., BOULU R. et SEYLAZ J. Relaxation by
dopaminergic agonists in cerebral and peripheral arteries "in vitro". Arch. Int. Pharmacodyn.
Ther., 1981, 252, 196-209.
MERIC P., SEYLAZ J., LUFT A. et MAMO H. Validité des mesures atraumatiques de débit
sanguin cérébral en pathologie cérébrovasculaire. Innov. Tech. Biol. Med. 1981, 2, 465-470.
MERIC P., LUFT A., SEYLAZ J. et MAMO H. Analysis of reproducibility and sensitivity of
atraumatic measurements of regional cerebral blood flow in cerebrovascular disease. Stroke,
1982, 14, 82-47.
SEYLAZ J., PINARD E., MERIC P. et CORREZE J.L. Local cerebral PO2, PCO2 and bloodflow measurements by mass spectrometry. Am. J. Physiol., 1983, 245, 513-518.
REYNIER-REBUFFEL A-M., PINARD E., AUBINEAU P.F., MERIC P. et SEYLAZ J.
Generalized cerebral vasoconstriction induced by intracarotid infusion of angiotensin II in
the rabbit. Brain Research, 1983, 269, 91-101.
OUDART N., SERCOMBE R. et SEYLAZ J. Relaxation of rabbit cerebral arteries "in vitro"by clonidine. Evidence of H2-receptor mediation. Arch. Int. Pharmacodyn., 1983, 265, 259273.
LASBENNES F., SERCOMBE R. et SEYLAZ J. The monoamine oxidase activity in brain
microvessels determined using natural and artificial substrates. Relevance to the blood-brain
barrier. J. Cereb. Blood Flow Metabol., 1983, 3, 521-528.
MAMO H., MERIC P., LUFT A. et SEYLAZ J. Evolution of the hyperfrontal distribution ofrCBF in advancing age. Excerpta Medica, 1983, 4, 226-230.
MAMO H., MERIC P., LUFT A. et SEYLAZ J. Hyperfrontal pattern of cerebral circulationin man. Variations with age and atherosclerotic state. Arch. Neurol., 1983, 40, 626-632.
MERIC P., LUFT A., MAMO H. et SEYLAZ J. Evolution du débit sanguin cérébral en
fonction de l'âge et des facteurs de risques vasculaires. Circulation et Métabolisme duCerveau, 1983, 1, 37-43.
PINARD E., ROUGIER P. et SEYLAZ J. Système nerveux, prostaglandines et hypoxie.
Circulation et Métabolisme du Cerveau, 1983, 1, 25-35.
PINARD E., TREMBLAY E., BEN-ARI Y. et SEYLAZ J. Blood flow compensates oxygen
demand in the vulnerable CA3 region of the hippocampus during kainate-induced seizures.
Neurosci., 1984, 13, 1039-1049.
LACOMBE P. et SEYLAZ J. Significance of the cerebrovascular effects of immobilizationstress in the rabbit. J. Cereb. Blood Flow Metabol., 1984, 4, 397-406.
SERCOMBE R., LASBENNES F., DROUET L., DOSNE A-M. et SEYLAZ J. Monoamineoxidase activity in the cerebral vasculature: comparison between fresh microvessels fromdifferent structures and cell cultures derived from microvessels. J. Cereb. Blood Flow
Metabol., 1984, 4, 415-424.
LASBENNES F., SERCOMBE R. et SEYLAZ J. Activité enzymatique MAO dans lesmicrovaisseaux isolés du cerveau de porc. Circulation et Métabolisme du Cerveau, 1984, 1,
243-250.

REYNIER-REBUFFEL A-M., AUBINEAU P.F., PINARD E., MERIC P. et SEYLAZ J.
Modification de l'hémodynamique cérébrale induite par l'angiotensine II. Circulation etMétabolisme du Cerveau, 1984, 1, 151-158.
LUFT A., PONSIN J.C., MERIC Ph., MAMO H. et SEYLAZ J. La mesure du débit sanguin
cérébral, technique de mesure et indications. Angiologie, 1984, 2, 10-12.
SEYLAZ J. Exploration de la circulation sanguine cérébrale et du métabolisme du cerveau.
Le Courrier du CNRS, Avril-Juin, 1984, n°55-56, 71-74.
VERRECCHIA C., SERCOMBE R. et SEYLAZ J. Rôle inhibiteur de l'intima des artères
cérébrales et périphériques dans la réponse aux monoamines cérébrales. Etudes "in vitro".
Circulation et Métabolisme du Cerveau, 1984, 2, 93-103.
AUBINEAU P., REYNIER-REBUFFEL A-M., BOUCHAUD C., JOUSSEAUME O. et
SEYLAZ J. Long term effects of superior cervical ganglionectomy on cortical blood flow of
non anaesthetized rabbits in resting and hypertensive conditions. Brain Research, 1985, 338,
13-23.
CASH R., LASBENNES F., SERCOMBE R., AGID Y. et SEYLAZ J. Adrenergic receptors
on cerebral microvessels in control and parkinsonian subjects. Life Sci., 1985, 37, 531-536.
LASBENNES F., SERCOMBE R., VERRECCHIA C. et SEYLAZ J. Vascular monoamineoxidase in the rat brain: variation with the substrate and the vascular segment. Life Sci., 1985,
36, 263-268.
VERRECCHIA C., SERCOMBE R. et SEYLAZ J. Influence of endothelium on
vasoconstriction induced by noradrenaline. Clin. Exp. Physiol. Pharmacol., 1985, 12 (2),169-179.
SERCOMBE R., VERRECCHIA C., OUDART N., DIMITRIADOU V. et SEYLAZ J. Pial
artery responses to norepinephrine potentiated by endothelium removal. J. Cereb. Blood
Flow Metabol., 1985, 5, 312-317.
PINARD E., LACOMBE P., REYNIER-REBUFFEL A-M. et SEYLAZ J. Intrinsic andextrinsic mechanisms involved in the cerebrovascular reaction elicited by immobilizationstress in rabbits. Brain Research, 1985, 340, 305-314.
MENASCHE P., PINARD E., DESROCHES A-M., LAGET P., GEYER R.P., SEYLAZ J. etPIWNICA A. Fluorocarbons: a potential treatment of cerebral air embolism in open-heart
surgery. Ann. Thoracic. Surg., 1985, 40, 494-497.
LACOMBE P., MILLER M.C. et SEYLAZ J. Sympathetic regulation of the cerebral bloodflow during a reflex hypertension. Am. J. Physiol., 1985, 249, 672-680.
SEYLAZ J. Rôle du système nerveux autonome dans la régulation de la circulation sanguine
cérébrale. Circulation et Métabolisme du Cerveau, 1985, 2, 115-132.
SERCOMBE R., VERRECCHIA C., PHILIPSON V., OUDART N., DIMITRIADOU V.,
BOUCHAUD C. et SEYLAZ J. Histamine-induced constriction and dilatation of rabbit
middle cerebral arteries "in vitro": role of the endothelium. Blood Vessels, 1986, 23, 137-153.
MRAOVITCH S., PINARD E. et SEYLAZ J. Two neural mechanisms in rat fastigial nucleus
regulating systemic and cerebral circulation. Am. J. Physiol., 1986, 251, 153-163.
MRAOVITCH S., LASBENNES F., CALANDO Y. et SEYLAZ J. Cerebrovascular changes
elicited by electrical stimulation of the centromedian-parafascicular complex in rat. Brain
Research, 1986, 380, 42-53.

LEVY B., PINARD E., MICHEL J.B., TEDGUI A. et SEYLAZ J. Transmural gradient oftissue gas tensions in the canine left ventricular myocardium during coronary clamping andreactive hyperemia. Pflügers Archiv., 1986, 407, 388-395.
LASBENNES F., LESTAGE P., BOBILLIER P. et SEYLAZ J. Stress and local cerebral
blood flow: studies on restrained and unrestrained rats. Exp. Brain Research, 1986, 63, 169172.
AUBINEAU P., DIMITRIADOU V., BOUCHAUD C., et SEYLAZ J. Direct innervation ofneurolipomastocytes in the rabbit and rat cerebral artery wall. Acta Physiol. Scand., 1986,
127, suppl.552, 21-24.
VERRECCHIA C., HAMEL E., EDVINSSON L., MacKENZIE E.T. et SEYLAZ J. Role ofthe endothelium in the pial artery responses to several vasoactive peptides. Acta Physiol.
Scand., 1986, 127, suppl.552, 33-36.
YOUNG A.R., MacKENZIE E.T., SEYLAZ J. et VERRECCHIA C. Receptors involved in
the five-hydroxytryptamine-induced contraction of isolated cerebral arteries. Acta Physiol.
Scand., 1986, 127, suppl.552, 54-57.
LACOMBE P., MILLER M.C., et SEYLAZ J. Variability of the sympathetic influence on
CBF as related to different physiological situations. Acta Physiol. Scand., 1986, 127,
suppl.552, 58-61.
REYNIER-REBUFFEL A.M., AUBINEAU P., et SEYLAZ J. Possible central mediation ofrCBF response to systemic norepinephrine. Acta Physiol. Scand., 1986, 127, suppl.552, 7881.
PINARD E., PUIROUD S., et SEYLAZ J. Specificity of the cerebrovascular regulation in the
rabbit caudate nucleus: effects of adenosine and catecholamines. Acta Physiol. Scand., 1986,
127, suppl.552, 82-85.
HALLER C., SERCOMBE R., VERRECCHIA C., FRITSCH H., KUSCHINSKY W. et
SEYLAZ J. Effects of the muscarinic agonist carbachol on pial arteries "in vivo" after
endothelium damage by air embolism. J. Cereb. Blood Flow Metabol., 1987, 7, 605-611.
LASBENNES F. et SEYLAZ J. Local cerebral blood flow in gently restrained rats: effects ofpropranolol and diazepam. Exp. Brain Research, 1987, 63, 163-168.
DIMITRIADOU V., AUBINEAU P., TAXI J. et SEYLAZ J. Ultrastructural evidence for afunctional unit between nerve fibers and type II cerebral mast cells in the cerebral vascularwall. Neuroscience, 1987, 22, 621-630.
REYNIER-REBUFFEL A-M., AUBINEAU P., ISSERTIAL O. et SEYLAZ J. Non
uniformity of CBF response to norepinephrine or angiotensin II induced hypertension in the
rabbit. Influence of anesthesia. Am. J. Physiol., 1987, 253, H47-H57.
PINARD E., RIGAUD A.S., RICHE D., NAQUET R. et SEYLAZ J. Continuous
determination of the cerebrovascular changes induced by bicuculline and kainic acid in
unanesthetized spontaneously breathing rats. Neuroscience, 1987, 23, 943-952.
PUIROUD S., PINARD E., MILLER M.C. et SEYLAZ J. Systemically administeredadenosine increases caudate blood flow in rabbits. Neuroscience Letters, 1987, 80, 224-228.
MRAOVITCH S. et SEYLAZ J. Metabolism-independent cerebral vasodilation elicited byelectrical stimulation of the centromedian-parafascicular complex in rat. Neuroscience
Letters, 1987, 83, 269-274.
MAMO H., MERIC Ph., PONSIN J.C., REY A., LUFT A. et SEYLAZ J. Cerebral bloodflow in normal pressure hydrocephalus. Stroke, 1987, 18, 1074-1080.

RIGAUD A.S., PINARD E., RICHE D., NAQUET R., SEYLAZ J. Comparaison desmodifications cérébrovasculaires induites dans l'hippocampe et le cortex lors de crisesépileptiques provoquées par l'acide kainique et la bicuculline. Circulation et Métabolisme duCerveau, 1987, 4, 167-174.
PERES M., MERIC P., BARRERE B., PASQUIER C., BERANGER G., BELOEIL J.C.,
LALLEMAND J.Y. et SEYLAZ J. "In vivo" 31P nuclear magnetic resonance (NMR) studyof cerebral metabolism during histotoxic hypoxia in mice. Metabolic Brain Disease, 1988, 3,
37-48.
DIMITRIADOU V., AUBINEAU P., TAXI J. et SEYLAZ J. Ultrastructural changes in the
cerebral artery wall induced by long-term sympathetic denervation. Blood Vessels, 1988, 25,
122-143.
LASBENNES F., LACOMBE P. et SEYLAZ J. Effect of monoamine oxidase inhibition on
the regional cerebral blood flow response to circulating noradrenaline. Brain Research, 1988,
454, 205-211.
PUIROUD S., PINARD E. et SEYLAZ J. Dynamic cerebral and systemic circulatory effects
of adenosine, theophylline and dipyridamole. Brain Research, 1988, 453, 287-298.
SEYLAZ J., HARA H., PINARD E., MRAOVITCH S., MacKENZIE E.T. et EDVINSSON
L. Effects of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat. J.
Cereb. Blood Flow Metabol., 1988, 8, 875-878.
ROUCHER P., MERIC P., CORREZE J.L., MISPELTER J., TIFFON B., LHOSTE J.M.,
SEYLAZ J. Contrôle du métabolisme énergétique cérébral chez l'animal vigile parspectroscopie RMN du 31P. Application à l'étude d'un modèle d'ischémie. Innov. Tech. Biol.
Med., 1988, 9, 657-669.
MRAOVITCH S. et SEYLAZ J. Modifications du débit sanguin et du métabolisme ducerveau provoquées par la stimulation électrique du complexe centromédian-parafasciculaire.
Circulation et Métabolisme du Cerveau, 1988, 5, 51-59.
BONVENTO G., LACOMBE P. et SEYLAZ J. Effets de la stimulation électrique du noyau
dorsal du raphé sur le débit sanguin cérébral local. Circulation et Métabolisme du Cerveau,
1988, 6, 71-72.
PINARD E., PUIROUD S. et SEYLAZ J. Role of adenosine in cerebral hypoxic hyperemia
in the unanesthetized rabbit. Brain Research, 1989, 481, 124-130.
BONVENTO G., LACOMBE P. et SEYLAZ J. Effects of electrical stimulation of the dorsal
raphe nucleus on local cerebral blood flow in the rat. J. Cereb. Blood Flow Metabol., 1989, 9,
251-255.
LACOMBE P., SERCOMBE R., VERRECCHIA C., PHILIPSON V., MacKENZIE E.T. et
SEYLAZ J. Cortical blood flow increases induced by stimulation of the substantia
innominata in the unanesthetized rat. Brain Research, 1989, 491, 1-14.
REYNIER-REBUFFEL A-M., AUBINEAU P., ISSERTIAL O. et SEYLAZ J. Effets de deux
agents hypertenseurs, norépinéphrine et angiotensine II, sur la relation pression artérielle etdébit sanguin cérébral régional chez le lapin éveillé ou anesthésié. Circulation etMétabolisme du Cerveau, 1989, 6, 47-55.
TRAN DINH Y.R., MAMO H., PONSIN J.C. et SEYLAZ J. Vasoréactivité au diamox dudiaschisis cérébelleux croisé dans les ischémies cérébrales du territoire carotidien.
Circulation et Métabolisme du Cerveau, 1989, 6, 73-74.
BONVENTO G., LACOMBE P. et SEYLAZ J. Cartographie cérébrale des vasoconstrictions
induites par la stimulation électrique du noyau dorsal du raphé chez le rat anesthésié.
Circulation et Métabolisme du Cerveau, 1989, 6, 315-322.

BONVENTO G., LACOMBE P., MacKENZIE E.T., ROUQUIER L., SCATTON B. et
SEYLAZ J. Differential effects of electrical stimulation of the dorsal raphe nucleus and of
cerfical sympathectomy on serotonin and noradrenaline concentrations in major cerebral
arteries and pial vessels in the rat. J. Cereb. Blood Flow Metabol., 1990, 10, 123-126.
PINARD E., RICHE D., PUIROUD S. et SEYLAZ J. Theophylline reduces cerebral
hyperaemia and enhances brain damage induced by seizures. Brain Research, 1990, 511, 303309.
BARRERE B., MERIC P., BORREDON J., BELOEIL J.C., BERENGER G., LALLEMAND
J.Y. et SEYLAZ J. Cerebral intracellular pH regulation during hypercapnia in unanesthetized
rats: a 31P nuclear magnetic resonance spectroscopy study. Brain Research, 1990, 516, 215221.
BARRERE B., PERES M., GILLET B., MERGUI S., BELOEIL J.C. et SEYLAZ J. 2D cosy
1H NMR: a new tool for studying in situ brain metabolism of the living animal. FEBS Letters,
1990, 264, 198-202.
ROUSSEL S., PINARD E. et SEYLAZ J. Kynurenate does not reduce infarct size after
middle cerebral artery occlusion in spontaneously hypertensive rats. Brain Research, 1990,
518, 353-355.
BELOEIL J.C., GILLET B., MERGUI S., CHAMPAGNAT J., FORTIN G., BARRERE B.,
PERES M. et SEYLAZ J. In vivo and in vitro two dimensional 1H NMR spectroscopy. Bull.
Magn. Res., 1990, 12, 15-22.
SERCOMBE R., HARDEBO J.E., KAHRSTROM J. et SEYLAZ J. Amine-induced
responses of pial and penetrating cerebral arteries: evidence for heterogeneous responses. J.
Cereb. Blood Flow Metabol., 1990, 10, 808-818.
RIGAUD A.S., PINARD E., BORREDON J. et SEYLAZ J. Effect of chronic cervicalsympathectomy on local cerebral blood flow during limbic seizures in rat. Brain Res., 1990,
532: 347-350.
TRAN DINH Y.R., THUREL C., SERRIE A., CUNING G. et SEYLAZ J. Effets de la
stimulation du ganglion trigéminal par le glycerol sur la circulation cérébrale chez l'homme.
Circ. Métabol. Cerveau, 1990, 7: 221-228.
PEARCE W.J., REYNIER-REBUFFEL A.M., LEE J., AUBINEAU P., IGNARRO L. et
SEYLAZ J. Effects of methylene blue on hypoxic cerebral vasodilatation in the rabbit. J.
Pharm. Exp. Ther., 1990, 254: 616-625.
ROUCHER P., MERIC P., CORREZE J.L., MISPELTER J., TIFFON B., LHOSTE J.M. et
SEYLAZ J. Metabolic effects of R-Phenyl Isopropyl Adenosine during reversible forebrainischemia studied by in vivo 31P nuclear magnetic resonance spectroscopy. J. Cereb. Blood
Flow Metab., 1991, 11: 453-458.
TCHAOUSSOFF J., MERIC P., BORREDON J., FEDELI O., GILLET B., BERENGER G.,
BELOEIL J.C. et SEYLAZ J. Intérêt de la spectroscopie RMN in vivo pour l'exploration dumétabolisme cérébral sous anesthésie volatile. Agressologie, 1991, 36: 6:66-71.
BARRERE B., BORREDON J., CORREZE J.L., MASSIOT D., MERIC P., PERES M.,
QUINIOU E., ROUCHER P. et SEYLAZ J. Etude quantitative de différentes méthodes detraitement quantitatif des spectres in vivo de résonance magnétique nucléaire du 31P, 19F et
1H du cerveau. Innov. Tech. Biol. Med., 1991,12: 6:706-722.
ROUSSEL S., PINARD E. et SEYLAZ J. Focal cerebral ischemia in chronic hypertension:
no protection by R-phenylisopropyladenosine. Brain Res., 1991, 545: 171-174.

HALLER C., SERCOMBE R., SEYLAZ J. et KUSCHINSKY W. Effect of moderate
endothelial damage on the in vivo reactivity of pial arteries to norepinephrine and serotonin.
Cerebrovascular Disease, 1991, 1: 288-295.
ROUCHER P., MERIC P., CORREZE J.L., MISPELTER J., TIFFON B., LHOSTE J.M. et
SEYLAZ J. Metabolic effects of Kynurenate during reversible forebrain ischemia studied byin vivo 31P nuclear magnetic resonance spectroscopy. Brain Res., 1991, 550: 54-60.
MENINI Ch., MRAOVITCH S., CALANDO Y., De La SAYETTE V., SILVA-BARRAT C.,
BRAILOWSKY S. et SEYLAZ J. Metabolic anatomy of the focal epilepsy produced bycessation of chronic intracortical GABA infusion in the rat. Neuroscience, 1991, 41: 607-615.
DAUPHIN F., LACOMBE P., SERCOMBE R., HAMEL E. et SEYLAZ J. Hypercapnia andstimulation of the substantia innominata increase rat frontal cortical cerebral blood flow bydifferent cholinergic mechanisms. Brain Res., 1991, 553: 75-83.
TRAN DINH Y.R., THUREL C., SERRIE A., CUNIN G. et SEYLAZ J. Glycerol injection
onto the trigeminal ganglion provokes selective CBF increase in man. Pain, 1991, 46: 13-16.
DAUPHIN F., RICHARD J.W., SEYLAZ J., QUIRION R. et HAMEL E. Acetylcholine
levels and choline acetyltransferase activity in rat cerebrovascular bed after uni- or bilateral
sphenopalatine ganglionectomy. J. Cereb. Blood Flow Metab., 1991, 11: 253-260.
BONVENTO G., LACOMBE P., MacKENZIE E.T. et SEYLAZ J. Effects of dorsal raphe
stimulation on cerebral glucose utilization in the anaesthetized rat. Brain Research, 1991,
567: 325-327.
REYNIER-REBUFFEL A.M., CALLEBERT J., DIMITRIADOU V., MATHIAU P.,LAUNAY J.M., SEYLAZ J. et AUBINEAU P. Carbachol induces granular cell exocytosis
and serotonin release in rabbit cerebral arteries. Am. J. Physiol., 1992, 262: R105-R111.
PERES M., BOURGEOIS D., ROUSSEL S., LE FUR Y., DE VOULON P., REMY C.,BARRERE B., DECORPS M., PINARD E., RICHE D., BENABID A.L. et SEYLAZ J. Twodimensional 1H spectroscopic imaging for evaluating the local metabolic response to focal
ischemia in the conscious rat. NMR in Biomedicine, 1992, 5: 11-19.
ROUSSEL S., PINARD E. et SEYLAZ J. The acute effects of MK-801 on cerebral bloodflow and tissue partial pressures of oxygen and carbon dioxide in conscious and alphachloralose anaesthetized rats. Neuroscience, 1992, 47: 959-965.
ROUSSEL S., PINARD E. et SEYLAZ J. Influence de l'hypertension artérielle sur laneuroprotection de l'ischémie focale. Circ. Métab. Cerveau, 1992, 9: 5-30.
IZUMI Y., ROUSSEL S., PINARD E. et SEYLAZ J. Reduction of infarct volume bymagnesium after middle cerebral artery occlusion in rats. J. Cereb. Blood Flow Metab. 1992,
11: 1025-1030.
PERES M., FEDELI O., BARRERE B., GILLET B., BERENGER G., SEYLAZ J. et
BELOEIL J.C. In vivo identification and monitoring of changes in rat brain glucose by twodimensional shift-correlated 1H NMR spectroscopy. Magn. Reson. Med., 1992, 27: 356-361.
ROUSSEL S., PINARD E. et SEYLAZ J. Effect of MK-801 on focal brain infarction innormotensive and hypertensive rats. Hypertension, 1992, 19: 40-46.
LASBENNES F., VERRECHIA C., PHILIPSON V. et SEYLAZ J. Muscarinic binding of
pial vessels and arachnoid membrane. J. Neurochem., 1992, 58: 2230-2235.
HERON A., LASBENNES F. et SEYLAZ J. Effets de composés adénosinergiques sur lalibération extracellulaire de glutamate. Circ. Métabol. Cerv., 1992, 9: 111-122.

DEBDI M., SEYLAZ J. et SERCOMBE R. Early changes in rabbit cerebral artery reactivity
after subarachnoid hemorrhage. Stroke, 1992, 23: 1154-1162.
HERON A., LASBENNES F. et SEYLAZ J. Effect of two different routes of administrationof R-PIA on glutamate release during ischemia. Neurosci. Lett., 1992, 147: 205-208.
MRAOVITCH S., CALANDO Y., GOADSBY P. et SEYLAZ J. Subcortical cerebral bloodflow and metabolic changes elicited by cortical spreading depression in rat. Cephalalgia,
1992, 12: 137-141.
MRAOVITCH S., CALANDO Y., PINARD E., PEARCE W.J. et SEYLAZ J. Differential
cerebrovascular and metabolic responses in specific neural systems elicited from thecentromedian-parafascicular complex. Neuroscience, 1992, 49(2): 451-466.
TRAN DINH Y.R., THUREL C., CUNIN G., SERRIE A. et SEYLAZ J. Cerebral
vasodilatation after the thermocoagulation of the trigeminal ganglion in humans.
Neurosurgery, 1992, 31: 658-663.
FLORENCE G. et SEYLAZ J. Rapid autoregulation of cerebral blood flow : a laser-doppler
flowmetry study. J. Cereb. Blood Flow Metabol., 1992, 12: 674-680.
COHEN Z., BONVENTO G., LACOMBE P., SEYLAZ J., MacKENZIE E.T. et HAMEL E.
Cerebrovascular nerve fibers immunoreactive for tryptophan-5-hydroxylase in the rat:
distribution, putative origine and comparison with sympathetic noradrenergic nerves. Brain
Research, 1992, 598: 203-214.
LACOMBE P., SERCOMBE R., CORREZE J.L., SPRINGHETTI V. et SEYLAZ J.
Spreading depression induces prolonged reduction of cortical blood flow reactivity in the rat.
Exp. Neurol., 1992, 117: 278-286.
DEBDI M., SEYLAZ J. et SERCOMBE R. Increased influence of calcium and nicardipine
on rabbit basilar artery reactivity after brief subarachnoid hemorrage. J. Cardiovasc.
Pharmacol., 1993, 21: 754-759.
HERON A., LASBENNES F. et SEYLAZ J. Adenosine modulation of amino acid release in
rat hippocampus during ischemia and veratridine depolarization. Brain Res., 1993, 608: 2732.
CUDENNEC A., BONVENTO G., DUVERGER D., LACOMBE P., SEYLAZ J. et
MacKENZIE E.T. Effects of dorsal raphe nucleus stimulation on cerebral blood flow andflow-metabolism coupling in the conscious rat. Neuroscience, 1993, 55: 395-401.
PERUZZI P., LACOMBE P., MORO V., VAUCHER E., LEVY F. et SEYLAZ J. The
cerebrovascular effects of physostigmine are not mediated through the substantia innominata.
Exp. Neurol., 1993, 122: 319-326.
MRAOVITCH S., CALANDO Y., ONTENIENTE B., PESCHANSKI M. et SEYLAZ J.
Cerebrovascular and metabolic uncoupling in the caudate-putamen following unilaterallesion of the mesencephalic dopaminergic neurons in the rat. Neuroscience Letters, 1993,
157: 140-144.
TRAN DINH Y.R., LOT G., BENRABAH R., BAROUDY O., COPHIGNON J. et SEYLAZ
J. Abnormal cerebral vasodilation in aneurysmal subarachnoid hemorrhage : use of serial
133Xe cerebral blood flow measurement plus acetazolamide to assess cerebral vasospasm. J.
Neurosurgery, 1993, 79: 490-493.
FLORENCE G., BONVENTO G., ROUCHER P., CHARBONNE R. et SEYLAZ J. Effect ofnimodipine on the autoregulation of cerebral blood flow studied by laser-doppler flowmetry.
Brain Res., 1993, 625: 301-306.

TRAN DINH Y.R., DEBDI M., COURAUD J.Y., CREMINON C., SEYLAZ J. et
SERCOMBE R. Time course of variations in rabbit cerebrospinal fluid levels of calcitonin
gene-related peptide- and substance P-like immunoreactivity in experimental subarachnoid
hemorrhage. Stroke, 1994, 25: 160-164.
HERON A., LEKIEFFRE D., LE PEILLET E., LASBENNES F., SEYLAZ J., PLOTKINE
M. et BOULU R.G. Effects of an A1 adenosine receptor agonist on the neurochemical,
behavioral and histological consequences of ischemia. Brain Res., 1994, 641: 217-224.
MERIC P., BARRERE B., PERES M., GILLET B., BERENGER G., BELOEIL J.C. et
SEYLAZ J. Effects of kainate-induced seizures on cerebral metabolism : a combined 1H and
31
P NMR study in rat. Brain Res., 1994, 638: 53-60.
FLORENCE G., BONVENTO G., CHARBONNE R. et SEYLAZ J. Spreading depression
reversibly impairs autoregulation of cortical blood flow. Am. J. Physiol., 1994, 266: R1136R1140.
LOUBINOUX I., MERIC P., BORREDON J., CORREZE J.L., GILLET B., BELOEIL J.C.,
TIFFON B., MISPELTER J., LHOSTE J.M. et SEYLAZ J. Cerebral metabolic changes
induced by MK-801 : a 1D (phosphorus and proton) and 2D (proton) in vivo NMR
spectroscopy study. Brain Res., 1994, 643: 115-124.
OSSARD G., CLERE J.M., KERGUELEN M., MELCHIOR F. et SEYLAZ J. Response ofhuman cerebral blood flow to +Gz accelerations. J. Appl. Physiol. 1994, 76: 2114-2118.
FLORENCE G., ROUCHER P., VALLET R., LEMENN M., CHARBONNE R. et SEYLAZ
J. Cortical blood flow and +Gz acceleration in conscious rabbits. J. Appl. Physiol. 1994, 76:
2527-2534.
BONVENTO G., MacKENZIE E.T., SEYLAZ J. et LACOMBE P. The cerebrovascular roleof the ascending serotonergic system : new vistas J. Auton. Nervous Syst., 1994, 49: S37-S42.
VAUCHER E., DAUPHIN F., SEYLAZ J. et LACOMBE P. Autoradiographic study of thecerebrovascular effects of stimulation of the substantia innominata : convenient stimulation
paradigm. J. Auton. Nervous Syst., 1994, 49: S43-S47.
BONVENTO G., SEYLAZ J. et LACOMBE P. Widespread attenuation of thecerebrovascular reactivity to hypercapnia following inhibition of nitric oxide synthase in the
conscious rat. J. cereb. Blood Flow Metabol., 1994, 14: 699-703.
SERCOMBE R., LACOMBE P., SPRINGHETTI V., MacKENZIE E.T. et SEYLAZ J. Basal
forebrain control of cortical blood flow and tissue gases in conscious aged rats. Brain
Research, 1994, 662: 155-164.
BONVENTO G., CHARBONNE R., CORREZE J.L., BORREDON J. et SEYLAZ J. et
LACOMBE P. Is α-chloralose plus halothane induction a suitable anesthetic regimen for
cerebrovascular research ? Brain Research, 1994, 665: 213-221.
RIGAUD-MONNET A.S., PINARD E., BORREDON J. et SEYLAZ J. Blockade of nitricoxide synthesis inhibits hippocampal hyperemia in kainic acid-induced seizures. J. Cereb.
Blood Flow Metabol., 1994, 14: 581-590.
REYNIER-REBUFFEL A.M., MATHIAU P., CALLEBERT J., DIMITRIADOU V.,
FARJAUDON N., KACEM K., LAUNAY J.M., SEYLAZ J. et AUBINEAU P. Substance P,
calcitonin gene-related peptide and capsaicin release serotonin from cerebrovascular mast
cells. Am. J. Physiol. 1994, 36: R1421-R1429.
AKOPOV S.E., SERCOMBE R. et SEYLAZ J. Endothelial dysfunction in cerebral vessels
following carotid artery infusion of phorbol ester in rabbits : the role of polymorphonuclear
leukocytes. J. Cereb. Blood Flow Metabol., 1994, 14: 1078-1087.

AKOPOV S.E., SERCOMBE R. et SEYLAZ J. Leukocyte-induced acute endothelial
dysfunction in middle cerebral artery in rabbits : responses to aggregating platelets. Stroke,
1994, 25: 2246-2252.
MARTEAU P., FLOURIE B., CHERBUT C., CORREZE J.L., PELLIER P., SEYLAZ J. et
RAMBAUD J.C. Digestibility and bulking effect of ispaghula husks in healthy humans. Gut,
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AKOPOV S.E., SERCOMBE R. et SEYLAZ J. Actions of platelet-activating factor on
isolated rabbit basilar artery : modulation by activated polymorphonuclear leukocytes. J.
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RIGAUD-MONNET A.S., HERON A., SEYLAZ J. et PINARD E. Effect of inhibiting NO
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GIRARD P., SERCOMBE R., SERCOMBE C., LE LEM G., SEYLAZ J. et POTIER P. A
new synthetic flavonoid protects endothelium-derived relaxing factor-induced relaxation in
rabbit arteries in vitro : evidence for superoxide scavenging. Biochem. Pharmacol., 1995, 49:
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KACEM K., SEYLAZ J., ISSERTIAL O. et AUBINEAU P. Chemical sympathectomy
favours vimentin expression in arterial smooth muscle cells of young rats. J. Auton. Nerv.
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HERON A., SPRINGHETTI V., SEYLAZ J. et LASBENNES F. Effects of a glutamate
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VAUCHER E., BORREDON J., SEYLAZ J. et LACOMBE P. Autoradiographic distributionof cerebral blood flow increases elicited by stimulation of the nucleus basalis magnocellularisin the unanesthetized rat. Brain Research 1995, 691: 57-68.
VAUCHER E., SEYLAZ J. et LACOMBE P. Autoradiographie de la réponse
cérébrovasculaire à la stimulation électrique du noyau basalis magnocellularis chez le ratéveillé. Circ. Métab. Cerveau, 1995, 12: 183-192.
MORO V., KACEM K., SPRINGHETTI V., SEYLAZ J. et LASBENNES F. Microvessels
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MORO V., BADAUT J., SPRINGHETTI V., EDVINSSON L., SEYLAZ J. et LASBENNES
F. Regional study of the colocalization of neuronal NOS with muscarinic receptors in the rat
cerebral cortex. Neuroscience, 1995, 69: 797-805.
AKOPOV S.E., SERCOMBE R. et SEYLAZ J. Leukocyte-induced endothelial dysfunctionin the rabbit basilar artery : modulation by platelet-activating factor. J. Lipid Med., 1995, 11:267-279.
TRAN DINH Y.R., LOT G., BENRABAH R., BAROUDY O., COPHIGNON J. et SEYLAZ
J. Abnormal cerebral vasodilation in aneurysmal subarachnoid hemorrhage : use of serial 133
Xe CBF measurement plus acetazolamide to assess cerebral vasospasm. Stroke, 1995, 25:
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BRULATOUT S., MERIC P., CORREZE J.L., LOUBINOUX I., BARRERE B., GILLET B.,
BERENGER G., BELOEIL J.C. et SEYLAZ J. Hypoxic hypoxia versus histotoxic hypoxia :an in vivo proton and phosphorus NMR spectroscopy study of the rat brain. Quart. Magn.
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NEHLIG A., VERGNES M., WAYDELICH R., HIRSCH E., CHARBONNE R.,
MARESCAUX C. et SEYLAZ J. Absence seizures induce a decrease in cerebral blood flow :human and animal data. J. Cereb. Blood Flow Metabol., 1996, 16: 147-155.
KACEM K., SEYLAZ J. et AUBINEAU P. Differential processes of vascular smooth muscle
cell differentiation within elastic and muscular arteries of rats and rabbits : an
immunofluorescence study of desmin and vimentin distribution. Histochemical Journal, 1996,
28: 53-61.
CHOLET N., BONVENTO G. et SEYLAZ J. Effect of neuronal NO synthase inhibition on
the cerebral vasodilatory response to somatosensory stimulation. Brain Research, 1996, 708:
197-200.
AKOPOV S., SERCOMBE R. et SEYLAZ J. Cerebrovascular reactivity : role ofendothelium/platelet/leukocyte interactions. Cerebrovasc. Brain Metab. Rev., 1996, 8:11-94.
OSSARD G., CLERE J.M., KERGUELEN G., MELCHIOR F. et SEYLAZ J. Cerebral bloodflow velocity response induced by a 70-hla Valsava manover associated with normo- andhypergravity in humans. Eur. J. Appl. Physiol., 1996, 72: 502-508.
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