Immunotoxicology Specialty
Section Newsletter
Pre-SOT bulletin
President’s Message
2013-2014
Executive Committee
President
Dr. Gary Burleson
Vice President
Dr. Danuta Herzyk
Vice President-ElectViP
id t El t
Dr. Rafael Ponce
Secretary-Treasurer
Dr. Haley Neff-LaFord
Past President
Dr. Gregory Ladics
Senior Councilor
Dr. Peyton Myers
Junior Councilor
Dr. Jamie Dewitt
PostDoc Representative
Dr Kinta Serve
Dr.
Student Representative
Aimee Hillegas

The ImTox SS Newsletter ispublished 3 times/year (Summer,(Summer
Fall, and Winter). If you would liketo share an item of interest withmembers of the ImTox SS, please
send it to the Communications
Committee Chair. All comments on,or suggestions to, the newsletterare welcome.

Ashwini Phadnis-Moghe, PhD
phadnisa@msu.edu

February 2014

Gary Burleson, PhD
Please make your plans to attend theSOT 53rd Annual Meeting in Phoenix, AZ
March 23-27 2014.
The program isoutstanding and the Immunotoxicology Section
highlights include numerous Immunotoxicology
Poster Sessions, Symposia: “To bug or Not to
Bug the Immune System: Benefits andConsequences of Altering the Microbiome” cochaired by Victor J. Johnson and Berran
Yucesoy, and “Ocular Immunotoxicology: A Dr. Gary Burleson
Privileged View” co-chaired by Brian Christian President, ImTox SS
2013-2014
and JoAnn Schuh; and the Workshop“Contribution
Contribution of Nonimmune Cells to Adverse Immune
Responses: Implications for Toxicology” co-chaired by Peer W.F.
Karmaus and Barbara Kaplan. The competition for approval andinclusion in the Annual Meeting is fierce. Please applaud the hard
work of the members of the Program Committee chaired by
Danuta Herzyk.
A list of ITSS committee members is included in thisnewsletter on page 5. I would like to encourage you to sign up for
ITSS 2014-2015 committees, and remember that if you sign up for
the Program Committee you must submit a proposal for
Continuing Education, Symposium, Workshop, Roundtable,
Informational Session, or the Education-Career Development
Session. Rafael Ponce will be Chair of the Programg
Committee
for the 2015 Annual Meeting. If you are interested in participating,please contact Rafael.
President’s Message……………………………………………………1
Student Post-doctoral Committee Report …….........……....….…..2
News and Noteworthy Events………………………..…………….....3
AAAS M
Meetingti U
Update.......................................................................4
d t
4
Immunotoxicology Committee Lists................................................5Workshop Announcement................................................................6
Recent Immunotoxicology Publications.........................................7
1

Immunotoxicology Specialty Section

An ITSS symposium presented at the 2013 SOT annual meeting was recently highlighted.
The SOT highlights and supports sessions presented at the annual meeting. The SOT
Scientific Program Committee selected the ITSS symposium entitled “Genetic and Epigenetic
Determinants of Susceptibility to Environmental and Occupational Toxicants” co-chaired by
ITSS members Drs. Victor J. Johnson and Berran Yucesoy and encouraged submission of thesymposium for presentation at the 2014 annual meeting of the American Association for
Advancement of Science (AAAS). The SOT supported the travel for session chairs andspeakers. This selection should encourage submission of ideas generated by our ITSS
members! (See page 4 for a detailed description of this AAAS Symposium).
F thoseForthattendingtt di theth meetingti in
i Phoenix,
Ph
i I would
ld likelik tot remind
i d you thatth t (1) The
Th ITSS
Executive Committee Breakfast will be held on Tuesday morning from 6:30 – 8:00 A.M. and (2)The Immunotoxicology Specialty Section (ITSS) Reception will be held on Wednesday at 6:00
P.M.
Please plan to attend the ITSS to meet with your fellow immunotoxicologists and recognize
this year’s award winners in the following categories:• ITSS Vos Lifetime Career Achievement Award in Immunotoxicology• ITSS Outstanding Senior Immunotoxicologist Award (NEW AWARD)• ITSS Outstanding Young Immunotoxicologist Award• ITSS Best Paper of the Year Award• ITSS Best Presentation by a Postdoctoral Trainee Award• ITSS Best Presentation by a Student Award• ITSS HESI Immunotoxicology
gy Youngg InvestigatorgTravel Award
During the ITSS reception, Kazuichi Nakamura will be a featured speaker. Dr. Nakamura
will discuss the continuing and important collaboration between the ITSS and the JSIT
(Japanese Society of Immunotoxicology). I look forward to seeing you at the SOT meeting in
Phoenix.
Immunotoxicology Specialty Section Reception
Sheraton Valley of the Sun C
Wed, March 12th - 6:00-7:30PM

Student & Postdoctoral Report
Submitted by Kinta Serve, PhD
SOT is right around the corner, and we hope you can all join us at the many fun andinformational events planned for that week. First, we will kick off SOT with the annual
Student/Postdoc mixer sponsored by the Graduate Student Leadership Committee. It is
FREE to students and postdocs (be sure to sign up when you register for the meeting) and willtake place on Sun, March 23rd, 7:30-9pm at the Sheraton Downtown hotel. This is a great
opportunity to network and learn more about specialty sections and regional chapters.
Throughout the week, the Graduate Student Leadership Committee and Postdoctoral
Assembly Board will host a number of educational events, including Chat with an Expert andPoster Tours. Both these events provide opportunities to meet with and learn from leading
experts in the toxicology field. Watch for emails for participant sign-ups.

February 20142

Immunotoxicology Specialty Section

The Postdoctoral Assembly Luncheon will take place on Tues, March 25 from noon-1:15
pm. Sign-up when you register for the meeting.
Lastly, there will be two big events for Immunotoxicology SS members on Wed, March 26th. The
place from 4:30-6 p
pm at the District American Kitchen
ImTox Student/Postdoc Mixer will take p
and Wine Bar inside the Sheraton Downtown hotel. Please join us for happy hour specials andmeet your fellow ImTox peers. Then, immediately afterwards, join us at the big ImTox
Reception from 6-7:30 pm in the Sheraton Downtown hotel. Enjoy appetizers and socializing
with fellow ImTox members. Awards will be presented during the reception.
We hope you can join us for all these fun and informative events!
Kinta Serve and Aimee Hillegas, Your ImTox postdoc and student representatives

NEWS AND NOTEWORTHY EVENTS
Dr. Rod Dietert wins Excellence in Teaching Award forscientific creativity
y course

Dr. Rod Dietert
Image courtesy:
vet.cornell.edu/news

Dr. Rod Dietert won the Inaugural Excellence in Teaching Award forundergraduate and graduate teaching presented by Cornell’s
Department of Microbiology and Immunology. Being a well-esteemed
professor of immunotoxicology, Dr. Dietert had explored a new teachingstyle and designed and taught a course called Tools for a Lifelong careerin Research. The idea of the class was to inspire fresh thinking andcreativity. The curriculum was based on a course that Dr. Dietertpresented at the 2012 SOT Postdoctoral Assembly-Sponsored workshop
in San Antonio. Congratulations Dr. Dietert for your contributions to thefield of science education!
For more information see: http://wwwvet cornell edu/news/dietert cfm
http://www.vet.cornell.edu/news/dietert.cfm

JOB OPPORTUNITIESJust a reminder that we are now including a new section in our newsletter to benefit anyone
who is looking for a new job or a career transition. If you are aware of a job opening that you
would like to see posted here, please email the details to the Communications Committee
Chair
this
and
Ch i at phadnisa@msu.edu.
h d i @d We
W willill updatedhi section
i in
i the
h upcoming
i newslettersld alsolpost them online on our website.
Employers who have job openings and would like to advertise them in our newsletter cansend the information to us in this format:
Position Available:
I tit ti or Company:
Institution
C
Bottles
B ttl R U
Us
Description: Chief Bottlewasher
Contact: Dr. Serve

February 20143

Immunotoxicology Specialty Section

Immunotoxicology representation at the AAAS meeting
Dr. Victor J. Johnson and Dr. Berran Yucesoy organized an exciting and cuttingedge symposium on the genetics,
genetics genomics,
genomics and epigenetics underlying susceptibility toenvironmental/occupational exposures. The symposium entitled “Genetic and Epigenetic
Determinants of Susceptibility to Environmental and Occupational Toxicants” was presented tothe toxicology community at the Society of Toxicology 2013 annual meeting. The symposium
was well received and the SOT Scientific Program Committee encouraged submission of thesymposium for presentation at the 2014 annual meeting of the American Association for
Advancement of Science,
Science AAAS.
AAASThe AAAS Program Committee accepted the symposium entitled “Genetic andEpigenetic Determinants of Susceptibility to Toxicants” which was recently presented at the180th annual meeting of AAAS (13-17 February 2014) in Chicago. SOT supported the travel
for the session chairs, Drs. Johnson (Burleson Research Technologies, Inc.) and Yucesoy(University of Cincinnati), as well as the excellent speakers, Dr. Cliona M. McHale (Universityof California,, Berkley),y), Dr. Steven R. Kleeburgerg ((National Institute of Environmental Health
Sciences), Dr. Dana Dolinoy (University of Michigan), and Dr. David Christiani (Harvard
University).
The symposium was well received at the AAAS meeting and the talks generated
an engaging discussion regarding the current and future of genetics/genomics/epigenetics intoxicology and risk assessment. Due to the extremely broad diversity of scientists and publicthat attend the meeting, the AAAS presents a unique challenge for effective communication of
the science that we are passionate about. A great lesson learned from this experience wasthat effective communication of science requires the scientist to engage a broad audiencerather than just delivering specialized knowledge to other experts in the field. In such a forum,
it is essential to connect the science, the scientist, and the audience in order to deliver themessage. In delivery of scientific findings, the ultimate goal should be to capture the interest of
those listening so that they leave wanting to know more.
We would like to thank Dr. Kerin,
MD from Kerin Occupational
HealthAssociates,
Toronto,Canada for his enthusiasm for thescience that we presented at
AAAS and for kindly providing
challenging discussions and thepicture.
Left to right: Dr. Noel Kerin, Dr.
Cliona McHale, Dr. Berran
Yucesoy, Dr. Steve Kleeberger,
Dr Dana Dolinoy,Dr.
Dolinoy Dr.
Dr Vic Johnson.
JohnsonFebruary 2014

4

Immunotoxicology Specialty Section

Immunotoxicology Committee Lists (2013-2014)
Communications Committee

Regulatory Committee

Membership Committee

Education Committee

Program Committee

Note: Committee chairs or co-chairs are highlighted in boldFebruary 2014

5

Immunotoxicology Specialty Section

Immunotoxicology Committee Lists (cont’d)Awards Committee

Workshop Announcement

Abstract:
Sensitization of the respiratory tract has significant acute and chronic health implications.
While the existence of inducers of respiratory sensitization is widely recognized for someclasses of chemicals, validated standard methods or frameworks for identifying andccharacterizing
a acteg tthee hazard
a ad a
are
e not
ot a
available.
a ab e Thiss workshopo s op aaims
s to ((1)) ddiscuss
scuss tthee cucurrente tstate of science for identification and characterization of respiratory sensitizer hazard, (2)identify the near-term and long-term information to facilitate development of validated standard
methods and frameworks, and (3) consider the regulatory and practical needs regarding risk
management.
Registration is now open, and space is limited. For more information and to register,
please visit http://www.hesiglobal.org/i4a/pages/index.cfm?pageid=3673 .
To learn more, please contact Dr. Connie Chen (cchen@hesiglobal.org).
February 2014

6

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Compiled by Haley Neff-LaFord

Anytime you have a new fully-published or electronically-available article to report, please
send the citation at anyy time to the coordinator,, Haleyy Neff-LaFord: hnlaford@seagen.com@
gAsthma, Allergy, Autoimmunity & Hypersensitivity
Almond RJ, Flanagan BF, Antonopoulos A, Haslam SM, Dell A, Kimber I and Dearman RJ.
Differential immunogenicity and allergenicity of native and recombinant human lactoferrins:
Role of glycosylation. Eur J Immunol 43:170-181, 2013.
Callahan A, Baron E, Fekedulegn D, Kashon M, Yucesoy B, Johnson VJ, Domingo DS,
Kirkland B, Luster MI and Nedorost S. Winter season, frequent hand washing, and irritantpatch test reactions to detergents are associated with hand dermatitis in health care workers.
Dermatitis 24:170-175, 2013.
Corsini E,
E Galbiati V,
V Nikitovic D and Tsatsakis AM.
AM Role of oxidative stress in chemicalallergens induced skin cells activation. Food Chem Toxicol 61:74-81, 2013.
Foster ES, Kimber I and Dearman RJ. Relationship between protein digestibility andAllergenicity: Comparisons of pepsin and cathepsin. Toxicology 309:30-38. 2013.
Galbiati V,
V Bianchi S,
S Martínez V,
V Mitjans M and Corsini E.
E NCTC 2544 and IL
IL-18
18 production:a tool for the in vitro identification of photoallergens. Toxicol In Vitro 28:13-47, 2014.
Gibbs S, Corsini E, Spiekstra SW, Galbiati V, Fuchs HW, Degeorge G, Troese M, Hayden P,
Deng W and Roggen E. An epidermal equivalent assay for identification and ranking potencyof contact sensitizers. Toxicol Appl Pharmacol 272:529-541, 2013.
Goebel C, Troutman J, Hennen J, Rothe H, Schlatter H, Gerberick GF and Blömeke B.
Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing
potency and reduces the risk of allergy induction. Toxicol Appl Pharmacol 274:480-487, 2014.
Johansson H, Albrekt AS, Borrebaeck CA and Lindstedt M. The GARD assay for assessmentof chemical skin sensitizers. Toxicol in Vitro 27:1163-1169, 2013.
Rivera-Mariani FE, Vysyaraju K, Negherbon J, Levetin E, Horner WE, Hartung T and Breysse
PN. Comparison of the interleukin-1β-inducing potency of allergenic spores from higher fungi(Basidiomycetes) in a cryopreserved human whole blood system. Int Arch Allergy Immunol
163:154-162, 2014.

February 20147

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Developmental Immunotoxicology
Bodin J, Bølling AK, Becher R, Kuper F, Løvik M and Nygaard UC. Transmaternal bisphenol A
exposure accelerates diabetes type 1 development in NOD mice. Toxicol Sci 137:311-323,
2014.
2014
Mathisen GH, Yazdani M, Rakkestad KE, Aden PK, Bodin J, Samuelsen M, Nygaard UC,
Goverud IL, Gaarder M, Løberg EM, Bølling AK, Becher R and Paulsen RE. Prenatal exposure
to bisphenol A interferes with the development of cerebellar granule neurons in mice andchicken. Int J of Dev Neurosci 31:762-9, 2013.
Viviani B, Boraso M, Valero M, Gardoni F, Marco EM, Llorente R, Corsini E, Galli CL, Di Luca
M, Marinovich M, López-Gallardo M and Viveros MP. Early maternal deprivation
immunologically primes hippocampal synapses by redistributing interleukin-1 receptor type I ina sex dependent manner. Brain Behav Immun 35:135-143, 2014.
General Immunotoxicology
Blum JL,JL Rosenblum LK,
LK Grunig G,
G Beasley MB,
MB Xiong JQ and Zelikoff JT.
JT Short-term
Short term
inhalation of cadmium oxide nanoparticles alters pulmonary dynamics associated with lunginjury, inflammation, and repair in a mouse model. Inhal Toxicol 26: 48–58, 2014.
Castano R, Johnson VJ and Cartier A. Challenge exposure to isocyanates induces changes innasal patency in patients reporting work-related respiratory symptoms. J Occup Environ Med
55:954-959
55:954
959, 2013.
2013
Corsini E, Budello S, Marabini L, Galbiati V, Piazzalunga A, Barbieri P, Cozzutto S, Marinovich
M, Pitea D and Galli CL. Comparison of wood smoke PM2.5 obtained from the combustion of
fir and beech pellets on inflammation and DNA damage in A549 and THP-1 human cell lines.
Arch Toxicol 87:2187-2199, 2013.
Corsini E, Galbiati V, Esser PR, Pinto A, Racchi M, Marinovich M, Martin SF and Galli CL.
Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells.
Arch Toxicol 88:415-24, 2014.
Corsini E, Pinto A, Galbiati V, Viviani B, Galli CL, Marinovich M and Racchi M. Corticosteroids
modulate the expression of the PKC-anchoring protein RACK-1 and cytokine release in THP-1
cells. Pharmacol Res doi: 10.1016/j.phrs.2014.01.002. Epub 2014.
Ferro A, Zebedeo CN, Davis C, Ng KW and Pfau JC. Amphibole, but not chrysotile, asbestos
induces anti-nuclear autoantibodies and IL-17 in C57Bl/6 mice.
J Immunotoxicol
doi:10.3109/1547691X.2013.847510. Epub 2013.
Looker C,
C Luster MI,
MI Calafat AM,
AM Johnson VJ,
VJ Burleson GR,
GR Burleson FG and Fletcher T.
T
Influenzavaccineresponsein
adultsexposedtoperfluorooctanoate
andperfluorooctanesulfonate. Toxicol Sci doi:10.1093/toxsci/kft269. Epub 2013.

February 20148

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Lundberg K, Albrekt AS, Nelissen I, Santegoets S, de Gruijl TD, Gibbs S and Lindstedt M.
Transcriptional profiling of human dendritic cell populations and models – unique profiles of invitro dendritic cells and implications on functionality and applicability. PLoS One 8:e52875,
2013.
2013
Ness D, Ren Z, Gardai S, Sharpnack D, Johnson VJ, Brennan RJ, Brigham EF and Olaharski
AJ. Leucine-rich repeat kinase 2 (LRRK2)-deficient rats exhibit renal tubule injury andperturbations in metabolic and immunological homeostasis. PLoS One 8:e66164 doi:
10.1371/journal.pone.0066164. Epub 2013.
Nikitovic D, Corsini E, Kouretas D, Tsatsakis A and Tzanakakis G. ROS-major mediators of
extracellular matrix remodeling during tumor progression. Food Chem Toxicol 61:178-186,
2013.
Seth RK, Das S, Kumar A, Chanda A, Kadiiska MB, Michelotti G, Manautou J, Diehl AM and
Chatterjee S. CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T
cells aid progression of environment-linked nonalcoholic steatohepatitis.
Toxiol Appl
Pharmacol 274:42-52, 2014.
Singh KP, Bennett JA, Casado FL, Walrath JL, Welle SL and Gasiewicz TA. Loss of arylhydrocarbon receptor promotes gene changes associated with premature hematopoetic stem
cell exhaustion and development of a myeloproliferative disorder in aging mice. Stem Cells
D
Developl 23:95-106,
23 95 106 2014.
2014
Vogel CF, Khan EM, Leung PS, Gershwin ME, Change WL, Wu D, Haarman-Stemmann T,
Hoffmann A and Denison MS. Cross-talk between aryl hydrocarbon receptor and theinflammatory response: A role for nuclear factor-κB. J Biol Chem 289:1866-1875, 2014.
Wheeler JLH,
JLH Martin KC,
KC Resseguie E and Lawrence BP.
BP Differential consequences of two
distinct AhR ligands on innate and adaptive immune responses to influenza A virus. Toxicol
Sci 137:324-334, 2014. Editor’s Choice.
Methods/Models
Klein SG, Serchi T, Hoffmann L, Blomeke B and Gutleb AC. An improved 3D tetraculture
system mimicking the cellular organisation at the alveolar barrier to study the potential toxic
effects of particles on the lung. Part Fibre Toxicol 10:31, 2013.
Martínez V, Galbiati V, Corsini E, Martín-Venegas R, Vinardell MP and Mitjans
M. Establishment of an in vitro photoassay using THP-1 cells and IL-8 to discriminate
photoirritants from photoallergens. Toxicol In Vitro 27:1920-1927, 2013.
Rivera-Mariani F.
Cryopreserved human wholeimmunotoxicological system. ATLA 41:1-8, 2013.

blood:

February 2014

Immunotoxicology Specialty Section

9

A human-based

in

vitro

Recent Immunotoxicology Publications
Teunis MAT, Spiekstra S, Smits M, Adriaens E, Eltze T, Galbiati V, Krul C, Landsiedel R,
Pieters R, Reinders J, Roggen E, Corsini E and Gibbs S. An international pre-validatoin study
on the Epidermal Equivalent sensitizer potency assay. Toxicol Lett 221:S133, 2013.
Reviews/Books/Commentaries
Angulo-Molina A, Reyes-Leyva J, Lopez-Malo A and Hernandez J.
tocopheryl succinate (α-TOS) as a potential anticancer agent.
10.1080/01635581.2014.863367. Epub 2013.

The role of alphaNutr Cancer doi:

BoverhofB
h f DR,DR Ladics
L di G,
G Luebke
L bk B,B Botham
B th
J CorsiniJ,
C i i E,E Evans
E
E Germolec
E,
G
l D,
D Holsapple
H l
l M,
M
Loveless SE, Lu H, van der Laan JW, White KL Jr, and Yang Y. Approaches andconsiderations for the assessment of immunotoxicity for environmental chemicals: A workshop
summary. Regul Toxicol Pharmacol 68:96-107, 2014.
Esser PR, Kimber I and Martin SF. Correlation of contact sensitizer potency with T cell
frequency and TCR repertoire diversity.
diversity In T Lymphocytes as Tools in Diagnostics and
Immunotoxicology. Experientia Supplementum. SF Martin (e.d.). Springer, Basel 2014. doi:
10.1007/978-3-0348-0726-5_8
Hartung T and Corsini E. Immunotoxicology: challenges in the 21st century and in vitro
opportunities. ALTEX 30:411-26, 2013.
Kimber I, Basketter DA, Thyssen JP, Dearman RJ and McFadden JP. Chemical allergy inhumans: Fresh perspectives. J Immunotoxicol doi: 10.3109/1547691X.2013.833661. Epub
2013.
Kimber I and Pallardy M. The use of T cells in hazard characterization of chemical and drug
allergens and integration in testing strategies. In: Martin SF (Ed.) T Lymphocytes as Tools in
Diagnostics and Immunotoxicology. Experientia Supplementum. Springer, Basel, 2014. doi:
10.1007/978-3-0348-0726-5_1.
Kimber I and Pieters R. Household chemicals, immune function, and allergy: A commentary.
J Immunotoxicol 10:169-172, 2013.
Smith
S
ith MJ,
MJ Brown
B
JM Zamboni
JM,
Z b i WC andd Walker
W lk NJ.
NJ FromFiimmunotoxicityt i it tot nanotherapy:
th
th
the
effects of nanomaterials on the immune system.
Toxicol Sci Invited Review doi:
10.1093/toxsci/kfu005 Epub 2014.
Johnson V. Tumor necrosis factor-α. In: Encyclopedia of Immunotoxicology. Vohr H. (Ed.)
Springer-Verlag Berlin Heidelberg, 2013.

February 201410

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Yucesoy B, Johnson V and Luster M. Cytokine genes and immunotoxicology, genetic variations. In:
Encyclopedia of Immunotoxicology. Vohr H. (Ed.) Springer-Verlag Berlin Heidelberg, 2013.
JohnsonJo so VJ,J, Dee Vooght
oog t V anda d Vanoirbeek
a o bee JA.
J (2013).
( 0 3) Animala Models.
ode s In: Asthma
st a in thet e Workplace:o p ace
Fourth Edition, Revised and Expanded. Bernstein, DI, Chan-Yeung M, Malo J-L and Bernstein IL (Eds.).
CRC Press, Boca Raton, FL

SAVE THE DATE!
53rd Annual Society of Toxicology Meeting
March 23-27, 2014
Phoenix, Arizona

Immunotoxicology Meeting/Reception
Wednesday, March 26
6:00-7:30pm
Sheraton Downtown Valley of the Sun C
Immunotoxicology Student/Postdoctoral mixer
Wednesday, March 26
4.30-6:00pm
District American Kitchen and Wine Bar
Sheraton Downtown Hotel
February 201411

Immunotoxicology Specialty Section