BMB2015

シンポジウム

第1日目

12月1日（火）【第1日目12月1日（火）】第2会場（神戸ポートピアホテル 本館 地下1階 偕楽1）

9:00-11:30【E】

Molecular system for creating, decoding, and destroying glycans
Organizers：Koichi Kato（National Institutes of Natural Sciences）
Shinji Miyata（Nagoya University）

Introduction 【9:00】

Shinji Miyata（Nagoya University）

1S2-1 【9:05】

Neurocan, a brain chondroitin sulfate proteoglycan, regulates neuronal migration and morphogenesis
during corticogenesis

Shinji Miyata1,2, Chihiro Sato1,3, Ken Kitajima1,3, Hiroshi Kitagawa4（1Biosci. Biotech. Center, Nagoya Univ., 2Inst. Adv.
Res., Nagoya Univ., 3Grad. Sch. Bioagr. Sci., Nagoya Univ., 4Dept. Biochem., Kobe Pharma. Univ.）

1S2-2 【9:25】

Functional analysis of enzymes involved in the formation of laminin-binding glycans displayed on
α-dystroglycan

Hirokazu Yagi1, Koichi Kato1,2（1 Grad. Sch. of Pharm. Sci., Nagoya City Univ., 2Okazaki Inst. for Integr. Biosci., Nat.
Inst. of Nat. Sci.）

1S2-3 【9:45】

Impact of tissue/animal-specific expression pattern of N -glycolylneuraminic acid
Yuko Naito-Matsui（Kobe Pharm. Univ.）

1S2-4 【10:05】Chemical synthesis of correctly folded and misfolded glycoproteins for understanding of glycoprotein
quality control system
Yasuhiro Kajihara（Dept. of Chem., Grad.Sch.of Sci., Osaka univ.）

1S2-5 【10:25】

Molecular recognition of glycopeptides by human immune receptor, PILR.
Katsumi Maenaka（Fac. Pharm. Sci., Hokkaido Univ.）

1S2-6 【10:45】Glycan conformation, dynamics and interaction with lectin receptors: a structural glycobiology approach
Yoshiki Yamaguchi（Struct. Glycobiol. Team, RIKEN）

1S2-7 【11:05】

Towards Understanding the physiological role of non-lysosomal glycan catabolism
Tadashi Suzuki（RIKEN, Glycometabolome T.）

Conclusion 
Koichi Kato（National Institutes of Natural Sciences）

1S3

第3会場（神戸ポートピアホテル 本館 地下1階 偕楽2）

【11:25】9:00-11:30【E】

Spontaneous pattern formation driven by cell-cell communication
Organizers：Eisuke Nishida（Kyoto University）
Miki Ebisuya（RIKEN）

Introduction 
Eisuke Nishida（Kyoto University）

1S3-1 【9:00】【9:03】

Reconstitution of cell-cell communication mechanisms
Miki Ebisuya（RIKEN QBiC）

Biochemistry and Molecular Biology

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第１日目

1S2

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シンポジウムシンポジウム

1S3-2 第１日目

Intercellular propagation of ERK activity and its role in collective cell migration.

第1日目

12月1日（火）【9:32】

Regulatory circuitry initiating two-dimensional stomatal patterning in the plant epidermis
Keiko Torii1,2（1Howard Hughes Medical Institute, 2University of Washington）

1S3-3 【10:01】

Kazuhiro Aoki（Grad. Sch. of Med., Kyoto University）

1S3-4 【10:30】Competitive interactions between normal and transformed epithelial cells
Yasuyuki Fujita（Dev. Mol. Onco., Inst. for Gen. Med., Hokkaido Univ.）

1S3-5 【10:59】What we can learn from a novel mechanism of constructing the architectural skeleton of sponges: how thepattern of spicule-holding-up (SHU) points is determined
Noriko Funayama（京大・院理・生物科学専攻・生物物理）

Conclusion 【11:28】Miki Ebisuya（RIKEN）

1S4

第4会場（神戸ポートピアホテル 本館 地下1階 偕楽3）

9:00-11:30【E】

Molecular Mechanisms of Brain and Mind development
Organizers：Fumio Matsuzaki（RIKEN）
Tomomi Shimogori（RIKEN）

Introduction 【9:00】

Fumio Matsuzaki（RIKEN ）1S4-1 【9:02】

Cortical expansion during the development of mammalian complex brains
Fumio Matsuzaki（Cell Asymmetry, RIKEN, CDB）

1S4-2 【9:29】The mechanisms of neuronal circuit formation and maturation in the postnatal brain
Tomomi Shimogori（RIKEN BSI）

1S4-3 【9:59】

Comprehensive 3D imaging of synaptic activity reveals rules directing experience-driven growth in awake
brain
Kurt Haas, Kaspar Podgorski, Serhiy Opushnyev（Centre for Brain Health, University of British Columbia）

1S4-4 【10:29】Stress-induced neuronal remodeling in the medial prefrontal cortex: Neuronal and microglial mechanisms
Tomoyuki Furuyashiki（Div. of Pharmacol., Grad. Sch. of Med., Kobe University）

1S4-5 【10:59】Involvement of posttranslational and epigenetic modifications in developmental brain disorders: Bedside
to bench, and back to bedside
Koko Ishizuka（Johns Hopkins University）

Conclusion 
Tomomi Shimogori（RIKEN）

78【11:29】

第38回日本分子生物学会年会／第88回日本生化学会大会 合同大会

BMB2015

第1日目

第14会場（神戸国際会議場 1階 メインホール）

12月1日（火）9:00-11:30【E】

科学研究費補助金 新学術領域研究「オートファジーの集学的研究：分子基盤から疾患まで」共催シンポジウム
Autophagy

Introduction 
Noboru Mizushima（The University of Tokyo）

1S14-1 【9:00】【9:05】

Formation and maturation of the autophagosome

Noboru Mizushima（Dept. of Biochem. & Mol. Biol., Grad. Sch. of Med., Univ. of Tokyo）

1S14-2 【9:30】New Insights into Autophagy in Diseases

Tamotsu Yoshimori（Grad. Sch. of FBS/Med, Osaka Univ.）

1S14-3 【9:55】

Visualization of the autophagic process using beads incorporated into living cells

Tokuko Haraguchi1,2,3, Shouhei Kobayashi1, Takako Koujin1, Hiroko Osakada1, Tomoko Kojidani1,4, Chie Mori1,
Yasushi Hiraoka1,2,3（1Advanced ICT Res. Inst., NICT, 2Grad. Sch. of Front. BioSci., Osaka Univ., 3Grad. Sch. of Sci.,
Osaka Univ., 4JWU）

1S14-4 【10:20】The lysosome as a signaling hub.

Andrea Ballabio1,2,3（1Director Tigem (Telethon Institute of Genetics and Medicine), 2Professor of Medical Genetics,
Department of Translational Medical Sciences, University of Naples "Federico II", Italy;, 3Professor, Department of
Molecular and Human Genetics, Baylor College of Medicine Jan and Dan Duncan Neurological Research Institute,Texas Children Hospital Houston, Texas, USA）

1S14-5 【11:00】

Molecular Mechanism of Autophagy Initiation in Yeast

Hayashi Yamamoto1, Sho W. Suzuki1, Yuko Fujioka2, Nobuo N. Noda2, Yoshinori Ohsumi1（1Frontier ResearchCenter, Tokyo Tech, 2Institute of Microbial Chemistry）

1S15

第15会場（神戸国際会議場 3階 国際会議室）

9:00-11:30【E】

Genomics and Epigenomics in Development and Evolution
Organizers：Hiroyuki Takeda（The University of Tokyo）
Koji Tamura（Tohoku University）

Introduction 
Hiroyuki Takeda（The University of Tokyo）

1S15-1 【9:00】【9:02】

Avian phylogenomic analyses revealed the macroevolution patterns of bird genomes

Guojie Zhang1,2（1China National Genebank, BGI-Shenzhen, Shenzhen, China, 2Section of Ecology and Evolution,
Department of Biology, University of Copenhagen, Copenhagen, Denmark）

1S15-2 【9:32】

Acquisition of novel cis -elements behind bird macroevolution

Ryohei Seki1, Cai Li2, Mao Kondo3, Tomohiko Sato3, Haruka Matsubara3, Daisuke Saito3,4, Shinichi Hayashi5, Shiro
Egawa3, Keiichi Kitajima3, Jiang Hu2, Luohao Xu2, Hailin Pan2, Naoki A. Irie6, Guojie Zhang2, Toshihiko Shiroishi1, Koji
Tamura3（1Mamm. Genet. Lab., NIG, 2China National Genebank, BGI-Shenzhen, 3Grad. Sch. of Life Sci., Tohoku Univ.,
4
FRIS, Tohoku Univ., 5Dept. of Genet., Cell Biol., and Dev., Univ. of Minnesota, 6Grad. Sch. of Sci., Univ. of Tokyo）

1S15-3 【9:53】High dosage sensitivity of genes maintained after whole genome duplication
Takashi Makino（Grad. Sch. of Life Sci., Tohoku Univ.）

Biochemistry and Molecular Biology

79

第１日目

Organizers：Noboru Mizushima（The University of Tokyo）
Maho Hamasaki（Osaka University）

シンポジウム

1S14

シンポジウムBMB2015

シンポジウムシンポジウム

1S15-4 

第１日目

Deciphering the genetic code for the vertebrate pluripotent epigenome

第1日目

12月1日（火）【10:14】The biological function of invertebrate DNA methylation in pre-mRNA processing
Miho M. Suzuki（National Institute for Basic Biology）

1S15-5 【10:35】

Ryohei Nakamura1, Masahiko Kumagai1, Sumio Sugano2, Yutaka Suzuki2, Shinichi Morishita2, Hiroyuki Takeda1（1Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 2Dept. of Comp. Biol and Med. Sci., Grad. Sch. of Front. Sci.,
Univ. of Tokyo）

1S15-6 【10:56】

A genetic mechanism for Batesian mimicry in swallowtail butterfly

Haruhiko Fujiwara, Hideki Nishikawa, Takuro Iijima（Grad. Sch. of Front. Sci., Univ. of Tokyo ）Discussion 【11:26】

Conclusion 【11:28】

Koji Tamura（Tohoku University）

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シンポジウム

第2日目

12月2日（水）【第2日目12月2日（水）】2S2

第2会場（神戸ポートピアホテル 本館 地下1階 偕楽1）

9:00-11:30【E】

Organelle biology: New pictures of cellular structures and functions
Organizers：Toshiya Endo（Kyoto Sangyo University）
Gia Voeltz（University of Colorado Boulder）

2S2-1 【9:00】

Toshiya Endo（Fac. of Life Sci., Kyoto Sangyo Univ.）

2S2-2 【9:25】New insights into the molecular mechanisms and the molecular evolution of chloroplast protein import
Masato Nakai（Inst. Prot. Res., Osaka Univ.）【9:50】

Import and assembly of mitochondrial proteins

Nikolaus Pfanner（Institute of Biochemistry and Molecular Biology, University of Freiburg, Germany）

2S2-4 【10:15】

Relationship between mitochondrial quality control and Parkinson's disease
Noriyuki Matsuda（Ubiquitin project, TMIMS）

2S2-5 【10:40】Analysis of ultrastructure and molecular mechanism of the mitochondrion and peroxisome dividing
machineries

Yuuta Imoto1, Yuichi Abe1, Masanori Honsho1, Kanji Okumoto2, Masaki Yoshida3, Haruko Kuroiwa4, Tsuneyoshi
Kuroiwa4, Yukio Fujiki1,2（1Med. Inst. of Bioregulation, Kyushu Univ., 2Dept. of Biol., & Grad. Sch. of Sys. Life Sci.,
Kyushu Univ., 3Grad. Sch. of Life and Environmental Sci., Univ. of Tsukuba, 4Dept. of Sci., Japan Woman's Univ.）

2S2-6 【11:05】

A tale of two dynamins during mitochondrial division

Gia Voeltz, Jason Lee（MCD Biology University of Colorado Boulder）

2S3

第3会場（神戸ポートピアホテル 本館 地下1階 偕楽2）

9:00-11:30【E】

For those with crystallophobia
Organizers：So Iwata（Kyoto University/Riken ）Mikako Shirouzu（RIKEN ）Introduction 
Mikako Shirouzu（RIKEN ）2S3-1 【9:00】【9:05】

Solid-state NMR of membrane proteins

Toshio Yamazaki, Toshio Nagashima（CLST, RIKEN ）2S3-2 【9:35】

Electron 3D crystallography and single particle analysis of membrane proteins
Koji Yonekura（RIKEN SPring-8 Center）

2S3-3 【10:05】

DIFFRACTION BEFORE DESTRUCTION: IMAGING SINGLE PARTICLES WITH X-RAY LASERS

Janos Hajdu1,2, Filipe R.N.C. Maia1,2, Tomas Ekeberg1,2（1Laboratory of Molecular Biophysics, Uppsala University,
Sweden, 2The European XFEL, Hamburg, Germany）

2S3-4 【10:55】

Role of lipid molecules on the proton antiport in MATE multidrug transporter
Yuji Sugita（RIKEN Theoretical Molecular Science Labo.）

Biochemistry and Molecular Biology

81

第２日目

2S2-3 シンポジウムProtein and lipid trafficking for mitochondrial biogenesis

BMB2015

シンポジウム

第2日目

12月2日（水）Conclusion 【11:25】

So Iwata（Kyoto University/Riken ）2S4

第4会場（神戸ポートピアホテル 本館 地下1階 偕楽3）

9:00-11:30【E】

New technologies for imaging and regulation of cellular proteins: from subcellular region to whole bodies
Organizers：Itaru Hamachi（Kyoto University）
Shigeki Kiyonaka（Kyoto University）
シンポジウムIntroduction 【9:00】

Itaru Hamachi（Kyoto University）

2S4-1 【9:00】

Synthetic molecules that control the location of proteins in living cells

第２日目

Shinya Tsukiji1,2（1Dept. of Sci. Technol. Innov., Nagaoka Univ. of Technol., 2Dept. of Bioeng., Nagaoka Univ. ofTechnol.）

2S4-2 【9:30】

Visualization of native AMPA receptors in central nervous systems using a novel chemical labelingtechnique

Shigeki Kiyonaka1,2, Sho Wakayama2, Michisuke Yuzaki3, Itaru Hamachi2,4（1Dept. Tech. Ecol., GSGES, Kyoto Univ.,
2
Dept. Synth. Chem. & Biol. Chem, Grad. Sch. Eng., Kyoto Univ., 3Dept. Physiol., Sch. Med., Keio Univ., 4CREST, JST）

2S4-3 【10:00】

Molecular and viral approaches to elucidate structure and function of neural circuits

Fumitaka Osakada1,2,3（1Lab. of Cell. Pharmacol., Grad. Sch. of Pharm. Sci., Nagoya Univ., 2Lab. of Neural Information
Processing, Inst. for Adv. Res., Nagoya Univ., 3PRESTO, JST）

2S4-4 【10:30】Regulatory mechanism of neural stem cells revealed by optical manipulation of gene expressions

Itaru Imayoshi1,2,3,4, Ryoichiro Kageyama2,3,5（1The Hakubi Center, Kyoto University, 2Institute for Virus Research,
Kyoto University, 3iCeMS, Kyoto University, 4Japan Science and Technology Agency, Precursory Research for
Embryonic Science and Technology (PRESTO), 5Japan. 5Japan Science and Technology Agency, Core Research for
Evolutional Science and Technology (CREST)）

2S4-5 【11:00】CUBIC: whole-organ, whole-body imaging with single-cell resolution using chemical cocktails

Kazuki Tainaka1,2, Etsuo A Susaki1,2, Shimpei I. Kubota1, Hiroki Ueda1,2（1Dept. of Sys. Pharmacol., Grad. Sch. ofMed., Univ. of Tokyo, 2Lab. for Syn. Biol., RIKEN QBiC）

2S14

第14会場（神戸国際会議場 1階 メインホール）

9:00-11:30【E】

The life sciences elucidated by the analysis of angio/lymphangiogenesis
Organizers：Kohei Miyazono（The University of Tokyo）
Nobuyuki Takakura（Osaka University）

2S14-1 【9:00】

Molecular and cellular mechanisms for the regulation of juxtapositional alignment of arteries and veins
Hiroyasu Kidoya, Nobuyuki Takakura（Dept. of Signal Transduction, RIMD, Osaka University）

2S14-2 【9:25】

Neuro-vascular crosstalk in the central nervous system
Yoshiaki Kubota（Dept of Vascular Biology, Keio Univ.）

2S14-3 【9:50】

Mechanotransduction in regulation of vascular homeostasis and remodeling
Jincai Luo（Institute of Molecular Medicine, Peking University）

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シンポジウム

第2日目

12月2日（水）2S14-4 【10:15】

Molecular mechanism underlying directional migration of endothelial tip cells during sprouting
angiogenesis
Shigetomo Fukuhara, Naoki Mochizuki（Dept. of Cell Biol., Natl. Cereb. & Cardiovasc. Res. Inst.）

2S14-5 【10:40】

Semaphorin/Plexin signaling pathway in lymphatic vascular patterning
Masanori Hirashima（Div. of Vasc. Biol., Grad. Sch. of Med., Kobe Univ.）【11:05】

New regulators of vascular sprouting and remodeling
Young-guen Kwon（Yonsei University）

2S15

第15会場（神戸国際会議場 3階 国際会議室）

9:00-11:30【E】

第２日目

Life driven by RNAs
Organizers：Mikiko C. Siomi（The University of Tokyo）
Kiyokazu Agata（Kyoto University ）Introduction 
Kiyokazu Agata（Kyoto University ）2S15-1 【9:00】【9:03】

A long noncoding RNA regulates an environmental sex determination in the crustacean Daphnia magna
Yasuhiko Kato, Hajime Watanabe（Dept. Biotech., Grad. Sch. Eng., Osaka Univ.）

2S15-2 【9:25】

Regulation of female fertility by lncRNA Neat1

Shinichi Nakagawa（RNA Biology Laboratory, RIKEN）

2S15-3 【9:47】

RNA-directed Genome Rearrangement in the Ciliate Oxytricha
Laura F. Landweber（Princeton University）

2S15-4 【10:17】

Multiple regulations of pluripotent stem cell by PIWI in planarians

Norito Shibata1, Makoto Kashima1, Kuniaki Saito2, Haruhiko Siomi2, Mikiko C. Siomi3, Kiyokazu Agata1（1Dept. ofBiophysics, Grad. Sch. of Sci., Kyoto Univ., 2Dept. of Mol. Biol., Keio Univ. Sch. of Med., 3Dept. of Biol. Sci., Grad. Sch.
of Sci., Univ. of Tokyo）

2S15-5 【10:39】Male Infertility Caused by Ubiquitination-deficient Mutations in Human Piwi (Hiwi)

Lantao Gou, Junyan Kang, Peng Dai, Xin Wang, Feng Li, Mofang Liu（State Key Laboratory of Molecular Biology,
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of
Sciences）

2S15-6 【11:09】PIWI-intracting RNA; its function and biogenesis

Mikiko C. Siomi（Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo）

Biochemistry and Molecular Biology

シンポジウム

2S14-6 

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シンポジウム

第3日目

12月3日（木）【第3日目12月3日（木）】3S2

第2会場（神戸ポートピアホテル 本館 地下1階 偕楽1）

9:00-11:30【E】

Nascent chains: the ribosome as a hub for protein quality control
Organizers：Hideki Taguchi（Tokyo Institute of Technology）
Toshifumi Inada（Tohoku University）

Introduction 【9:00】

Hideki Taguchi（Tokyo Institute of Technology）

3S2-1 【9:02】

Ubiquitylation of Stalled Ribosome Triggers Ribosome Quality Control

Toshifumi Inada（Dept. of Mol. Cell Biol.,Grad. Sch. of Pharm. Sci., Tohoku Univ.）

3S2-2 【9:24】

Structural insights into regulation and failure of eukaryotic translation termination
Roland Beckmann（Gene Center, Munich University）

3S2-3 【9:54】

シンポジウム

Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria

Hiroyuki Mori1, Eiji Ishii1, Shinobu Chiba2, Narimasa Hashimoto1, Seiji Kojima3, Michio Homma3, Koreaki Ito2,
Yoshinori Akiyama1（1Inst. Virus Res., Kyoto Univ., 2Kyoto Sangyo Univ., 3Grad. Sch. Sci., Nagoya Univ.）

3S2-4 【10:16】Mapping the cotranslational chaperone network in eukaryotic cells

第３日目

Judith Frydman （Stanford University, Stanford, CA 94305）

3S2-5 【10:46】

Molecular mechanism of the translation arrest by SecM

Zhuohao Yang, Ryo Iizuka, Yuanfang Guo, Shunsuke Yamashiro, Takashi Funatsu（Grad. Sch. of Pharm. Sci., Univ.
of Tokyo）

3S2-6 【11:08】Global analysis of yeast protein aggregation using a reconstituted cell-free translation system
Hideki Taguchi, Eri Uemura, Tatsuya Niwa（Grad. Sch. Biosci. and Biotech., Tokyo Tech.）

3S3

第3会場（神戸ポートピアホテル 本館 地下1階 偕楽2）

9:00-11:30【E】

Molecular Basis of Oxidative-Electrophilic Stress Response
Organizers：Masayuki Yamamoto（Tohoku University）
Masaaki Komatsu（Niigata University）

3S3-1 【9:00】

p62 promotes malignancy of hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Masaaki Komatsu（Dept. Biochem., Grad. Sch. of Med., Niigata Univ.）

3S3-2 【9:30】The regulation of p62-Nrf2-Keap1 axis in dysregulation of lipid metabolism and oxidative stress

Soo han Bae1,2,3（1Severance Biomedical Science Institute, 2Yonsei Biomedical Research Institute, 3Yonsei University
College of Medicine）

3S3-3 【10:00】Redox regulation of magnesium-ion transporter MagEx/CNNM

Yosuke Funato, Daisuke Yamazaki, Hiroaki Miki（Dept. of Cell. Reg., Res. Inst. for Microb. Dis., Osaka Univ.）

3S3-4 【10:30】Antioxidant Electrophilic Signaling Regulated by Reactive Sulfur Species and Its Translational Biosynthesis
Takaaki Akaike（Dept. of Health Sci. and Mol. Toxicol., Grad. Sch. Med., Tohoku Univ.）

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第3日目

12月3日（木）

3S3-5 【11:00】

Critical Roles Keap1-Nrf2 System Plays in Stress Response

Masayuki Yamamoto（Dept. of Med. Biochem., Grad. Sch. of Med., Tohoku Univ.）

3S4

第4会場（神戸ポートピアホテル 本館 地下1階 偕楽3）

9:00-11:30【E】

Cell and Time
Organizers：Hitoshi Okamura（Kyoto University）
Yumiko Saga（National Institute of Genetics）

Introduction 
Hitoshi Okamura（Kyoto University）

3S4-1 【9:00】【9:02】「Time in the Cell」~ Why is the circadian clock suppressed in pluripotent stem cells?~

Kazuhiro Yagita（Dept. of Physiol. and Syst. Biosci., Grad. Sch. of Med., Kyoto Pref. Univ. of Med.）

3S4-2 【9:25】

Dynamic expression of Notch ligand Dll1 during development【9:48】【10:11】

第３日目

3S4-3 シンポジウムHiromi Shimojo1,2, Hiroshi Kori3, Akihiro Isomura2, Toshiyuki Ohtsuka2, Hitoshi Miyachi2, Ryoichiro Kageyama1,2（1iCeMS, Kyoto University, 2IVR, Kyoto University, 3Dept. of Information Sci., Ochanomizu University）

An intrinsic buffering mechanism in spermatogonial stem cells controls the timing of mouse
spermatogenesis
Yumiko Saga, Zhi Zhou（NIG）

3S4-4 Dynamics of stem cell system in intestinal epithelium.

Toshiro Sato, Yuki Ohta, Mariko Shimokawa, Yoshihiro Nakazato, Kosaku Nanki（Department of Gastroenterology,
Keio University School of Medicine）

3S4-5 【10:34】

Liver polyploidy: Dr Jekyll or Mr Hide?

Chantal Desdouets（Institut Cochin, Inserm U1016, Paris）

3S4-6 【10:57】

Cell clock and cell cycle

Hitoshi Okamura1,2（1Dept. Systems Biol., Grad. Sch. Pharm. Sci., Kyoto Univ., 2CREST, JST）

Discussion 【11:20】Conclusion 【11:29】

Yumiko Saga（National Institute of Genetics）

3S14

第14会場（神戸国際会議場 1階 メインホール）

9:00-11:30【E】

Customizing cells and organisms using genome editing
Organizers：Takashi Yamamoto（Hiroshima University）
Akitsu Hotta（Kyoto University）

3S14-1 【9:00】

Genome editing with programmable site-specific nucleases

Takashi Yamamoto（Dept. of Math. Life. Sci., Grad. Sch. of Sci., Hiroshima Univ.）

3S14-2 【9:10】

Structural basis for molecular mechanisms of CRISPR-Cas9

Osamu Nureki（Dept. of Bioph. and Bioch. Grad. Sch. of Sci., Univ. of Tokyo）

Biochemistry and Molecular Biology

85

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第3日目

3S14-3 

12月3日（木）【9:30】

Genome-editing technologies in HIV research

Hirotaka Ebina, Shuhei Ueda, Yuka Kanemura, Naoko Misawa, Yoshio Koyanagi（Institute for Virus Research,
Kyoto Univ.）

3S14-4 【9:50】

Improved PITCh systems: enhancing convenience, efficiency, and applicability of MMEJ-mediated geneknock-in

Tetsushi Sakuma, Shota Nakade, Yuto Sakane, Ken-ichi Suzuki, Takashi Yamamoto（Dept. of Math. and Life Sci.,
Grad. Sch. of Sci., Hiroshima Univ.）

3S14-5 【10:10】

Genome Editing in Stem Cells, Animals, and Plants

Jin-soo Kim1,2（1Dept. of Chemistry, Seoul National Univ., 2Center for Genome Engineering, Institute for Basic
Science）

3S14-6 【10:50】Generation of genetically modified pigs by genome editing

Hiroshi Nagashima（Meiji University International Institute for Bio-Resource Research）

シンポジウム3S14-7 【11:10】

The genome editing technologies in marmoset for creating new primate models

Erika Sasaki1,2（1Dept. of App. Dev. Biol.,Central Institute for Experimental Animals, 2Keio Advanced ResearchCenter, Kio Univ.）

第３日目

3S15

第15会場（神戸国際会議場 3階 国際会議室）

9:00-11:30【E】

Genetic/Epigenetic Regulation and Reconstitution In Vitro of Germ Cell Development
Organizers：Mitinori Saitou（Kyoto University）
Katsuhiko Hayashi（Kyushu University）

3S15-1 【9:00】

Stochasticity and hierarchy of spermatogenic stem cells
Shosei Yoshida（Natl. Inst. Basic Biology）

3S15-2 【9:30】Sex Chromosomes and Mammalian Infertility

James MA Turner（Francis Crick Institute, Mill Hill Laboratory, London, UK）

3S15-3 【10:00】Intrinsic and age-related sources of aneuploidy in eggs
Tomoya Kitajima（RIKEN CDB）

3S15-4 【10:30】Reconstitution of mouse oogenesis in vitro

Katsuhiko Hayashi1, Orie Hikabe1, Nobuhiko Hamazaki1, Norio Hamada1, Yasuyuki Ohkawa2（1Dept. of Stem Cell
Biol., Faculty of Med., Kyushu Univ., 2Dept. of Advanced Medical Initiatives, Faculty of Med., Kyushu Univ.）

3S15-5 【11:00】

Towards Understanding and Reconstitution In Vitro of Human Germ Cell Development

Mitinori Saitou1,2,3,4（1Dept. of Anat. Cell Biol., Grad. Sch. of Med., Kyoto Univ., 2JST, ERATO, 3iCeMS, Kyoto Univ.,
4
CiRA, Kyoto Univ.）

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第4日目

12月4日（金）【第4日目12月4日（金）】4S2

第2会場（神戸ポートピアホテル 本館 地下1階 偕楽1）

9:00-11:30【E】

The busy world of plant cells: dynamic organelle movements and their physiological roles
Organizers：Ikuko Hara-Nishimura（Kyoto University）
Kentaro Tamura（Kyoto University）

Introduction 【9:00】

Kentaro Tamura（Kyoto University）

4S2-1 【9:05】The Unique Nucleocytoplasmic Linkage in Plants

Kentaro Tamura（Dept. of Biol. Sci., Grad. Sch. of Sci., Kyoto Univ.）

4S2-2 【9:30】

A mystery of busy cytoplasmic streaming in quiet plants

Motoki Tominaga（Dep. Biol., Fac. Educ. Integrated Arts and Sci., Waseda Univ.）

4S2-3 【9:55】

Molecular dynamics in chloroplast photorelocation movement

Samgeun Kong1,2（1Div. Struct. Biol. Med. Inst. of Bioreg. Kyushu Univ., 2Res. Cent. Live-Protein Dynamics, Kyushu
Univ.）

4S2-4 【10:20】

Active movements and network formation of the endoplasmic reticulum in plant cells

Haruko Ueda1, Etsuo Yokota2（1Grad. Sch. of Sci., Kyoto Univ., 2Grad. Sch. of Life Sci., Univ. of Hyogo）

4S2-5 【10:45】

Cortical microtubule patterning in xylem cells

Discussion 【11:10】Conclusion 【11:25】

Ikuko Hara-Nishimura（Kyoto University）

第3会場（神戸ポートピアホテル 本館 地下1階 偕楽2）

9:00-11:30【E】

Understanding of organogenesis beyond the hierarchy of multicellular behaviors
Organizers：Akira Kikuchi（Osaka University）
Mototsugu Eiraku（RIKEN）

Introduction 
Akira Kikuchi（Osaka University）

4S3-1 【9:00】【9:01】

Spatial and Temporal Regulation of the Neural Tube Pattern Formation
Noriaki Sasai（Bio. Sci., NAIST）

4S3-2 【9:26】

Self-organized formation of complex tissues from stem cells
Mototsugu Eiraku（RIKEN CDB）

4S3-3 【9:50】

Identification of novel stem cells by the multicolor lineage tracing method
Hiroo Ueno（Dept. Stem Cell Pathology, Kansai Medical University）

4S3-4 【10:15】Multiscale modeling and simulation to explore the role of mechanical forces that shape living tissues andorgansTaiji Adachi, Yasuhiro Inoue, Yoshitaka Kameo（Dept. of Biomech., Inst Frontier Med. Sci., Kyoto Univ.）

Biochemistry and Molecular Biology

87

第４日目

4S3

シンポジウムYoshihisa Oda1,2, Yoshinobu Nagashima1,3, Yuki Sugiyama1,3, Hiroo Fukuda3（1National Insitute of Genetics,
2
SOKENDAI, 3Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo ）BMB2015

シンポジウム

第4日目

12月4日（金）4S3-5 【10:40】Fine-tuning of differentiation and morphogenesis of tubular organs by Wnt signaling

Akira Kikuchi, Shinsuke Fujii, Takayuki Kurimoto, Souji Ibuka, Shinji Matsumoto（Dept. of Molbio. Biochem., Grad.
Sch. of Med., Osaka Univ.）

4S3-6 【11:04】

Kidney progenitor expansion and generation of vascularized glomeruli from stem cells

Ryuichi Nishinakamura, Shunsuke Tanigawa, Sazia Sharmin, Atsuhiro Taguchi（Inst. Mol. Embryol. Genet.,
Kumamoto Univ.）

Conclusion 【11:29】Mototsugu Eiraku（RIKEN）

4S4

第4会場（神戸ポートピアホテル 本館 地下1階 偕楽3）

9:00-11:30【E】

New aspects of lipid biology unveiled by lipidomics –from bench to clinic–
Organizers：Hiroyuki Arai（The University of Tokyo）
Junken Aoki（Tohoku University）

4S4-1 【9:00】

Comprehensive lipidomics and Mass/LipidBank databases

Masanori Arita1,2, Hiroshi Tsugawa2（1Natl Instit Genet, 2RIKEN CSRS）

4S4-2 【9:23】

Single cell lipidomics approach for diseases

Mitsutoshi Setou（Dept.of Cell Biology and Anatomy,Hamamatsu Univ. Sch. of Medicine）

4S4-3 【9:46】

Measuring phosphoinositides at molecular species level

シンポジウムHiroki Nakanishi1,4, Satoshi Eguchi2, Masaki Ishikawa1, Akira Suzuki3, Junko Sasaki2, Takehiko Sasaki1,2,4（1ResearchCenter for Biosignal, Akita University, 2Department of Medical Biology, Graduate School of Medicine, Akita
University, 3Medical Institute of Bioregulation, Kyushu University, 4Akita Lipid Technologies, Inc.）

4S4-4 【10:09】Function of organellar membrane lipids as a scaffold of intracellular signal integration

第４日目

Hiroyuki Arai1,2, Tomohiko Taguchi2（1Department of Health Chemistry, Graduate School of Pharmaceutical
Sciences, University of Tokyo, 2 Laboratory Pathological Cell Biology, Graduate School of Pharmaceutical Sciences,
University of Tokyo）

4S4-5 【10:32】

Platelet-activating factor and eicosanoid regulation by LPCAT2

Hideo Shindou1,2, Takao Shimizu1,3（1NCGM Lipid Signal, 2JST CREST, 3Dept. of Lipid. Fac. of Med. Univ. of Tokyo）

4S4-6 【10:50】

Lipoquality regulation by the phospholipase A2 family

Makoto Murakami1,2（1Tokyo Metropolitan Institute of Medical Science, 2AMED-CREST）

4S4-7 【11:13】

LPA3 signal protects the heart against ischemic injury through activation of the vagus nerve
Kuniyuki Kano1,2, Junken Aoki1,2（1Grad. Sch. of Pham. Sci., Tohoku Univ., 2AMED）

4S14

第14会場（神戸国際会議場 1階 メインホール）

9:00-11:30【E】

Maintenance and plasticity of epigenetic memory
Organizers：Yoichi Shinkai（RIKEN）
Jun-ichi Nakayama（Nagoya City University）

Introduction 
Jun-ichi Nakayama（Nagoya City University）

88【9:00】

第38回日本分子生物学会年会／第88回日本生化学会大会 合同大会

BMB2015

シンポジウム

第4日目

12月4日（金）4S14-1 【9:05】

Epigenetic Inheritance Uncoupled from Sequence-Dependent Establishment
Danesh Moazed（Harvard Medical School, HHMI）

4S14-2 【9:30】

Crosstalk between histone modifications during heterochromatin assembly
Jun-ichi Nakayama（Div. of Biol. Sci., Grad. Sch. of Nat. Sci., Nagoya City Univ. ）4S14-3 【9:50】

Establishment and maintenance of histone modifications

Bing Zhu（Institute of Biophysics, Chinese Academy of Sciences）

4S14-4 【10:15】

Protracted NP95 binding to hemimethylated DNA disrupts proviral silencing
Haruhiko Koseki, Jafar Sharif（RIKEN-IMS）

4S14-5 【10:40】A histone mimic within DNA Ligase 1 recruits UHRF1 to sites of DNA replication: implications for DNA
remethylation

Alexandra Fournier1, Laure Ferry1, Takeshi Tsusaka2, Tadahiro Shimazu2, Kyohei Arita3, Yoichi Shinkai2, PierreAntoine Defossez1（1CNRS, Paris, France, 2RIKEN, Wako, Japan, 3Yokohama City University）

4S14-6 【11:00】

Epigenome changes induced by environmental factors and their memory
Shunsuke Ishii（Lab of Molecular Genetics）

Conclusion 【11:25】

Yoichi Shinkai（RIKEN）

4S15

第15会場（神戸国際会議場 3階 国際会議室）

9:00-11:30【E】

Organizers：Yoshihiro Ogawa（Tokyo Medical and Dental University）
Motoko Yanagita（Kyoto University ）Introduction 
4S15-1 【9:00】【9:03】

Cellular and molecular bases of pulmonary fibrosis

Kouji Matsushima（Dept. of Mol. Preventive Med., Faculty of Med., The Univ. of Tokyo）

4S15-2 【9:32】

Intravital imaging analysis of different macrophages, bone tissue maintaining osteoclasts and residential
macrophages in adipose tissues
Masaru Ishii（Dept. of Immunol. Cell Biol., Grad. Sch. of Med. Front. Biosci., Osaka Univ.）

4S15-3 【10:01】

Liver Tissue Injury and Remodeling

Ekihiro Seki（Div. of Gatroenterol. Dept. of Med., Cedars-Sinai Med. Ctr.）

4S15-4 【10:30】Obesity-induced adipose tissue remodeling and the metabolic syndrome

Takayoshi Suganami1,2,3, Miyako Tanaka1,2, Michiko Itoh2, Yoshihiro Ogawa2,4（1Dept. of Molecular Medicine andMetabolism, Res. Inst. of Environmental Medicine, Nagoya Univ., 2Dept. of Molecular Endocrinology and Metabolism,
Grad. Sch. of Medical and Dental Sci., Tokyo Medical and Dental Univ., 3PRESTO, JST, 4CREST・AMED）

4S15-5 【10:59】A brain-heart-kidney network controls adaptation to cardiac stress and remodeling through tissue
macrophage activation
Ichiro Manabe（Dept. Cardiovasc. Med., Grad. Sch. Med., Univ. Tokyo）

Biochemistry and Molecular Biology

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第４日目

Yoshihiro Ogawa（Tokyo Medical and Dental University）

シンポジウムTissue Remodeling and Diseases

BMB2015

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第4日目

12月4日（金）Conclusion 【11:28】

Motoko Yanagita（Kyoto University ）CSHA session

第9会場（神戸ポートピアホテル 本館 地下1階 菊水）14:00-16:30【E】

Metabolism, cancer and diseases
Organizer：Maoyen Chi（Cold Spring Harbor Laboratory/CSH Asia）

Introduction 
Maoyen Chi（Cold Spring Harbor Laboratory/CSH Asia）

CSHA-1 【14:00】【14:20】The Mitochondrial Pyruvate Carrier as a Target for Treating Diabetes
Finck Brian（Washington University School of Medicine）

CSHA-2 【14:50】

The Role of Seipin in Adipogenesis and Lipid Droplet Expansion(rob) yang Hongyuan（School of Biotechnology and Biomolecular Sciences, the University of NSW）

CSHA-3 【15:20】A new method of drug delivery that selectively targets senescent cells

Daniel Munoz-Espin1, Cristina Gimenez2, Irene Galiana2, Jose Ramon Murguia2, Ramon Martinez-Manez2, ManuelSerrano1（1Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain, 2Centre for Molecular Recognition
and Technological Development (IDM),Polytechnic University of Valencia (UPV), 46022 Valencia, Spain ）CSHA-4 【15:50】Adipose Tissue Dysregulation and Metabolic Complications in Obesity

Jong In Kim, Sung Sik Choe, Jin Young Huh, Jae Bum Kim（Department of Biological Science, Institute of
Molecular Biology & Genetics, Seoul National University, Seoul 151-742, Korea）

シンポジウム
第４日目

90

第38回日本分子生物学会年会／第88回日本生化学会大会 合同大会