ImmunoTox Letter
English pages

pathological respiratory/vascular conditions(Drs. Ken-ichiro Inoue, Rie Yanagisawa, EikoThe 15th Annual Meeting of theJapanese Society of Immunotoxicology(JSIT2008)

Koike, Hirohisa Takano, National Institue forEnvironmental Studies)(4) Skin exposure and skin penetration ofnanomaterials: prediction of their possibilities

September 11-12, 2008

(Prof. Kenji Sugibayasi, Josei University）

Tower Hall Funabori, Edogawa, Tokyo, Japan

17:05-18:05

TEL：03-5676-2211 FAX：03-5676-2501

Invited Plenary Lecture“Immunotoxicology of innate immunity”
Prof. Stephen B. Pruett, College of Veterinary

Organizing Committee of the 15th Annual Meeting ofMedicine, Mississippi State University, USAJSIT

18:30-20:30

Reception（2F Hou-rai）

President: Jun-ichi Sawada, National Institute ofHealth Sciences

September 12

Secretary General: Reiko Teshima, National Institute8:40 Registrationof Health Sciences

9:10-11:35

Oral presentations

Mail Address: jsit2008@nihs.go.jp

10:00-12:00

Symposium “Gut-associated lymphoid

URL: http://jsit2008.umin.ne.jp/

tissues and their regulations”--------------------------------------------------------------------------(Organized by Drs. R. Teshima and Y. Kanazawa)

Program (tentative schedule)(1) Regulation of gut immunity by retinoids (Dr.
Makoto Iwata , Tokushima Bunri University）

September 11(2) Intestinal immunity-mediated allergy：

9:00 Registration

stablishment of murine food allergy model (Dr.

10:00 Opening Remark

Shindo, Hatano Laboratory, Food and Drug

10:05-10:45

Safety Center)

Keynote Lecture “Genetic polymorphismsand myelotoxicity of anti-cancer drugs”(3) Immunomodulation by probiotic lactobacilli

Dr. Jun-ichi Sawada, National Institute ofthrough regulating functions of macrophages

Health Sciences(Dr. Kan Sida, Yakuruto Honnsha）

10:50-11:35

Oral Presentations(4) M u c o s a l i m m u n e d y s f u n c t i o n b y t h e

11:40-12:20

General Assembly

trichothecene mycotoxins (Prof. Pestka,

12:30-13:15

Luncheon Seminar (Charles River

Michigan State University)

Laboratories)（2F Zui-un）
13:25-14:55

Oral Presentations

15:00-17:00

Symposium “Immunotoxicity of nanoparticles”

12:10-12:55

Luncheon Seminar (Huntingdon LifeSciences)（2F Zui-un）
13:05-13:50 Oral Presentations(Organized by Drs. T. Otsuki, S. Hirano and H.

13:55-14:35 Poster Discussion（4F Seminar Room）

Fujimaki)

14:40-15:25

Master’s Lecture “Immunotoxicogenomics(1) Measures to evaluate the health effects

of environmental chemicals” (Sep. 12)of manufactured nanomaterials (Dr. Akihiko

D r. K e i k o N o h a r a , N a t i o n a l I n s t i t u e o fHirose, National Institute of Health Sciences）

Environmental Studies, Japan(2) The importance of characterization for

15:30-17:30

Workshop “Secondary immunomodulatory

nanoparticles and its pulmonary effects in rats.

effects and allergenicity of pharmaceuticals”(Dr. Akira Ogami, University of Occupational(Organized by Drs. N. Tutui and S. Hisada)and Environmental Health）(1) Immunomodulatory effect of PPAR agonists(3) Synergistic effects of nanoparticles on(Dr. Shigeharu Ueki, University of Akita)─ 12 ─

Vol. 13 No. 1 (2008)
with members as frequently and soon as possible.

(2) Immunomodulatory effect of dopamice (Dr.

In addition to the member survey done byKazuhisa Nakano, University of Occupational

Director-Information, it was planed to set up theand Environmental Health)

homepage of JSIT and complete member’s e-mail(3) Validation of non-RI LLNA method –Testing

list for close communication. The electronic formats

method- (Dr. Hajime Kojima, National Institutewere established after many ef forts of successiveof Health Sciences)

Secretary-Generals. Now we can see the ImmunoTox(4) Validation of non-RI LLNA method –DataLetter on the homepage and down-load its back-number.

analysis- (Dr. Takashi Omori, Kyoto University

This makes it easy to send information of JSIT toSchool of Public Health)members and to communicate each other among(5) Report on ICCVAM LLNA peer review (Prof.

members. However, it is sorry that the Society budget

Takahiko Yoshida, Asahikawa Medical College)
17:30-17:35

Awards Ceremony

17:35-17:40

Closing Remark

turned tight with more expense for the homepage beyond
the expected. Then I would like to ask members for nodelay of membership renewal.
The third policy is that the JSIT takes active partA message from theformer President of JSIT– Expectations for New Research Trends
in Immunotoxicology

for international collaboration in the research ofimmunotoxicology. Prior to this action plan a working
group (project leader: Dr. Sawada) was organized formaking ICH guidance of immunotoxicology. At ICH

Motoyasu OHSAWA

conference or else JSIT members of the group took

Teikyo University and Hatano Research Institute, Food and Drugactive part for preparing the guidance. Moreover, theSafety Center, Japan

JSIT working group for the future vision also suggested
promoting international exchange of researchers. It wasIn April, 2002, I succeeded Prof. Hiroshi Nagura, thenecessary for the purpose to open English homepage

first President, to serve as President of the Japaneseof JSIT, and it is realized now. Since JSIT2005 meeting

Society of Immunotoxicology (JSIT). It has since passed(Tokyo) researchers have been exchanged at eachsix years for the two terms of the duty, while I had been

Annual Meeting between JSIT and Immunotoxicology

pushed to manage the Society. Now I feel ease at passing

Specialty Session (Director: Prof. Pruett) of Society ofbaton to new President Dr. Jun-ichi Sawada, and also feel

Toxicology (SOT), USA. International communication

sorry I could have contributed more to the Society.

has been rapidly activated, and JSIT comes to mediate

As reported already at the Annual Meeting JSIT2007

international research collaboration. It is further desired(Kobe), during last terms of duty, the Society has been

to communicate closely with immunotoxicologists inmanaged under the following policies: 1) to form the firmother countries, in particular Asian countries.

Society system, 2) to communicate open with members,and 3) to promote international collaboration.

Thus we are having most of results expected for theFor the first policy, according to proposal by theworking committee, the councillorship was introducedpolicies. After now it is further expected that JSIT may
improve academic status on such basis of the Society.

in addition to the Directorate, to activate the Society.

There are many new challenges in immunotoxicology:

Although complex system is less favorable to not adevelopments of more efficient and reliable assay systems

big Society, the councillorship would be essential for(e.g. in vitro test system, high-throughput screening, etc.),

keeping and refreshing activities. It is further desired toconcept forming of tailor-made immunotoxicology forencourage turnover among members, Councillors andhigh-risk population, establishment of safety evaluation

Directors, and active commitment by Councillors to thefor bioproducts (biologicals, biotechnology-derivedSociety.

foods, biotechnology-derived pollutants, etc.) and for

For the second policy it was undertaken to communicate

high-tech products (nano-tech products, new materials,

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ImmunoTox Letterand electromagnetic waves, etc.), and elucidation of risk

シリーズ「免疫毒性研究の若い力」
An article of request4

factors in increasing allergic and autoimmune diseases
and improvement of preventive and therapeutic methods

Atopy and DEPagainst the diseases, and so on. JSIT may be greatly

Masaharu Muranaka, MD1,Shuji Suzuki, MD2,
Masao Yamaguchi, MD3

expected to address these challenges. I really thankall of members for much collaboration, feeling happy
that I could do a main part of my duties and pass the1baton toward new progress in immunotoxicology with

Yugawara Kosei-Nenkin Hospital2

expectations to the Society.

3Takashimaya Clinic

Department of Allergy and Rheumatology, University of Tokyo
Graduate School of Medicine

Through long-term studies on the immediate type

Greeting from the Executive President

drug allergy, the author realized importance of two

Jun-ichi Sawada

factors other than atopic disposition for the IgE antibody

Executive Presidentproduction. One was the route of the antigen to enter
into the body, and another was the role of substances withThe Japanese Society of Imunotoxicology (JSIT) wasadjuvant activities. Intramuscular injection of 20 units offounded in 1994 as a small researcher’s society. WeACTH-Z preparation at weekly intervals produced IgEappreciate much effort made by the former Presidents,

antibody even in patients with non-atopic asthma andDrs. Hiroshi Nagura and Motoyasu Ohsawa to establish

those with rheumatoid arthritis. Mice models using alumand expand the Society. The aims of the Society, togel or activated carbon as an adjuvant were established,educate young immunotoxicologists, to release thein which case some commercial penicillin preparations

newest immunotoxicological information to the public,

could elicit passive cutaneous anaphylactic (PCA)

to facilitate cooperations among immunotoxicologists

reactions.

in different fields, and to contribute to the development

Diesel-exhaust particulates (DEP) are thought to beof safer drugs and chemicals, are still valid even after

akin to activated carbon since both have huge surface

fourteen years.

area. Adjuvant activity of DEP was ascertained for theproduction of IgE against the Major Antigen of Japanese

As the immunotoxicology field has expanded from

Cedar Pollen (JCPA) in this mice model. It was confirmed

the classical immunotoxicity (immunosuppression) tothat DEP inoculated by the intranasal route had anunintended immunoenhancement (or immunomodulation)

adjuvant activity for IgE antibody production in mice.

including autoimmunity and chemical and food allergy,

This confirmation has contributed to explain the reason

our Society has been more interdisciplinary. The topics

why the rate of Japanese Cedar pollinosis, pure IgE

or keywords in current toxicology include “ecological”

dependent allergic disease, increases rapidly in Japan totoxicity, “high-risk group”, newly developed materials likethe levels far beyond that of atopic disposition.

“nanoparticles”, and new technologies like “omics” and“epigenetics”. These also apply to immunotoxicology,
and we must challenge these new aspects. In this point,
the role of the Society as a platform for interdiciplinary
communications becomes more important.
Finally, from an international point of view, theSociety would promote cooperations with foreign
immunotoxicologists, including Asian researchers.

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Vol. 13 No. 1 (2008)

シリーズ
Youngpowerfor immunotoxicological research「免疫毒性研究の若い力」
4An innate immunity-based approachfor examining immunotoxicity-Bacteriology has led me to the fieldof immunotoxicologyKei-ichi Sugiyama, Ph. D.
Senior Researcher
Division of Microbiology, National Institute of Health Sciences

My Ph. D. degree was obtained in the field of stressresponse of de novo glutathione synthesis in budding
yeast from Kyoto University in 2000. Since then, I worked
as a researcher at a pharmaceutical company to develop
a novel method for screening drug. At present, I havebeen on Division of Microbiology, National Instituteof Health Sciences. In this institute, I am researchingeffects of mycotoxins which are fungal toxins on innate
immunity. My scientific field has included bacteriology
since receiving my Ph. D., which led me to participate
in immunotoxicological research and presented a lotof exciting new science to me. Hence, I would like tocontinue innate immunity-based explorations intomechanisms of immunotoxicity, and then believe that myresearch can make a contribution to this society.

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