The 2nd Annual Meeting of JSIT
1995.9.29.
Kamijo Auditoriium, Showa University （Tokyo）
President: Yukio KUROIWA (School of Pharmaceutical Sciences, Showa University )Special Lecture
Immunotoxicological evaluationof chemicals and therapeutics: Michael I. Luster
an update perspective

Environmental Immunology& Neurobiology Section
National Institute ofEnvironmental Health
Sciences/NIH, NC

Workshop
Y. Nomoto(1),K.
Taguchi(2),Y.
Sugihara(3),Y.
Amano(4),K.

(1)Kyorin Pharmaceutical,(2)Marion Merrell Dow,
(3)Eisai, (4)Kowa,(5)Shionogi, (6)Taihoand pathological investigation - Kawano(9),S.
Inoue(10),K.
Hayakawa(11),N.
Tsutsui(12)(10)Hoechst Japan,(11)Mitsui Pharmaceutical,(12)Mitsubishi
PharmaceuticCollaborative immunotoxicity
study by seven-day oral
administration ofcyclophosphamide hematological, blood chemical

Collaborative
immunotoxicological study byseven-day oral administration

Nakamura(5),Y.
Kouchi(6),H.
Nakamura(7),T.
Masuda(8),S.

Pharmaceutical, (7)Takeda
Chemical Industries,(8)Lederle (Japan),(9)Bristol-Myers Squibb,

H. Nakamura(1),S.
Inoue(2),Y.
Sugihara(3), T.

(1)Takeda Chemical
Industries, (2)Hoechst
Japan, (3)Eisai, (4)Lederle

Collaborative
immunotoxicological study byseven-day oral administrationof cyclophosphamide evaluation of humoral immune
response by plaque-forming
cell assay and enzyme-linked
immunosorbent assay-

K. Nakamura(1),S.
Kawano(2),S.
Inoue(3),Y.
Sugihara(4),T.
Masuda(5),Y.
Kouchi(6),M.
Hayakawa(7)(1)Shionogi, (2)BristolMyers Squibb, (3)Hoechst
Japan, (4)Eisai, (5)Lederle(Japan), (6)Taiho
Pharmaceutical,(7)Mitsui
Parmaceutical

Collaborative immunotoxicity
study by seven-day oral
administration of
cyclophosphamide - naturalkiller activity, macrophage
phagocytosis, colony-forming
unit granulocyte/macrophage -Y. Kouchi(1),M.
Hayakawa(2),Y.
Sugihara(3),N.
Tsutsui(4)(1)Taiho Pharmaceutical,(2)Mitsui, (3)Eisai,(4)Mitsubisi Chemicalof cyclophosphamide cellularity, flow cytometricanalysis, mitogenic stimulation
assay -Mini-symposium

Masuda(4),Y.
Kouchi(5),K.
Nakamura(6)(Japan),(5)Taiho
Pharmaceutical,(6)Shionogi

Assessment of lymphocyte
subpopulations in workers

T. Tanigawa,S. Araki,A.

exposed to hazardous

Nakatasubstances

Department of Public
Health, Faculty of Medicine,
University of Tokyo
Department ofImmunotoxicity of low doseformaldehyde exposure

T. Yoshida

Environmental Health,Tokai University School ofMedicine

Role of proinflammatory

F. Kayama(1),M. I.

(1)Dept. of Environ Health,

Luster(2)UOEH, (2)NIH/NIEHS

Study on the method for

H. Shionoya,Y.

Dept. of Drug Safety

predicting drug-allergy

Nonogaki,F. Sagami

Research, Eisai Co. Ltd.

Antigenicity of metabolic
intermediates in aminopyrine
allergy

H. Shigematsu(1),Y.
Hisanari(1),A.
Toda(1),R. Eyanagi(2)(1)Dept. of HygienicChemistry, Daiichi Collegeof Pharmaceutical Sciences,(2)Daiichi UniversityCollege of Technology

Pseudoallergy system using rat
basophilic leukemia cell:
phorbol ester potentiated a
microsomal Ca2+ ATPase
inhibitor to release histamine

S. Kitajima(1),J.
Momma(1),M.
Tsuda(1),Y.
Kurokawa(1),R.
Teshima(2),J.
Sawada(2)(1)Div. of Toxicology(2)Div. of Biochemistry andImmunochemistry, National
Institute of Health Sciences

cytokines in cadmium-induced
hepatic and renal toxicity
general Presentation

Determination of the optimum
conditions in the enzyme-linked
M. Nagata,K.
immunosorbent assay ofNakamura
antibody to sheep red bloodcells

Developmental ResearchLaboratories Shionogi &Co., Ltd.

Daiichi Parmaceutical Co.,
M. Miyamoto,H.
Comparison of ELISA andLtd., Developmental
Hattori,F.
plaque forming cell assays for
Research Laboratories,
Yamaguchi,H. Ohno,M.
measuring anti SRBC antibodies
Drug Safety Research
NomuraCenter
Improvement of histologicalexaminations for the detectionof immunotoxicity using
biological parameters of cellproliferation and cell death

K. Toyoda,T. Shoda,C. Division of Pathology,
Uneyama,K. Takada,M. National Institute of Health
TakahashiSciencesK. Takegawa,H.
Histopathological study on
Division of Pathology,
Onodera,K.
lymphoid tissue atrophy in rats
National Institute of Health
Mitsumori,T. Shimo,K.
treated with piperonyl butoxide
SciencesYasuhara,M. Takahashi
Immunotoxicological evaluationof dexamethasone in mice
N. Tsutsui(1)(2),T.
infected with Plasmodium
Kamiyama(1)chabaudi
Influence of HMG-CoA
reductase inhibitors on plaqueforming cell (PFC) response inmice

T. Kimura(1),K.
Shinkai(1),H.
Masuda(1),T.
Komai(2),K.
Nomoto(3)(1)NIH of Japan,(2)Mitsubishi ChemicalCorporation(1)Laboratory Animal
Science and Toxicology
Laboratories,(2)Pharmacology andMolecular Biology Research

Laboratories, Sankyo Co.,
Ltd., (3)Medical Institute of
Bioregulation, Kyushu
University
Effects of quinolone
antibacterial agents on humoral
immune response in mice

Effects of cytotoxic agents onperipheral lymphocyte andneutrophil nuclei

H. Hattori,M.
Miyamoto,F.
Yamaguchi,H. Ohno,M.
NomuraK. Nagami,Y.
Kawashima,T. Akima,K.
Motegi,Y. Ban,K.
Samura,H. Matsumoto

Drug Safety ResearchCenter, Developmental
Research Laboratories,
Daiichi Pharmaceutical Co.,Ltd.
Development ResearchLaboratories, Banyu
Pharmaceutical Co., Ltd.

Comparison of in vitro colony

Tokushima Researchformation of bone marrow cells
K. Matsumura,A. Ozaki Institute, Otsuka
between C57BL/6 mice and SD
Pharmaceutical Company
rats
Toxic effects of 5-fluorouracil toY. Maeda,Y. Kouchi,A.
the hematopoietic progenitor
Ohuchida
cells in mouse bone marrow

Drug Safety ResearchLaboratory, Taiho
Pharmaceutical Co., Ltd.

Evaluation of in vitro toxicity of32 MEIC compounds on human Y. Kobayashi
natural killer cell function

Lab.of Molecular
Immunology, Faculty ofScience, Toho University

Immunodeficiency byorganotin-induced thymus
atrophy and its tolerance
manifestation

J. Murata(1),Y.
Arakawa(1),H.
Nakashima(2)(1)Dept. of Hygiene andPreventive Medicine,
Faculty of Healty Sciences,
University of Shizuoka, (2)Osaka Prefectural Instituteof Public Health

Changes of cell functions inmurine macrophages and T
cells by lead compounds

K. Takagi,M.
Kanematsu,T.
Kawabe,Y. Suketa

Dept of Environmental
Biochemistry, School of
Pharmaceutical Science,
University of Shizuoka

experimental hepatitides andsuppression of cytokine

F. Takano,K. Konno,S.
Fushiya,Y. Kondo,Y.

Faculty of Pharmaceuticalproduction bybisbenzylisoquinoline alkaloids

Yamazoe,H. Hojo

Protective activity onTolerance to transpulmonary
neutrophil infiltration and someproblems in evaluation ofpulmonary toxicity

S. HiranoSciences, Tohoku University

Regional Environ. Div., Natl.
Inst. Environ. Studies