Vol. 18 No. 1 (2013)

English pages

Program (Tentative Schedule)■September 12, 2013 (THU)The 20th Annual Meeting of JSIT 2013
(Japanese Society of Immunotoxicology)

・The 20th Memorial Symposium
・Luncheon Seminar 1・Award Lectures

September 12–13, 2013
Auditorium (Daigaku Yongou-kan), Tokai University
Yoyogi Campus

・Educational Lecture 1
・Oral / Poster presentation
・Social gathering

2-28-4 Tomigaya, Shibuya-ku, 151-8677 Tokyo, Japan.

Campus Cafeteria

Organizing Committee of the 20th Annual Meeting ofJSIT■September 13, 2013 (FRI)

http://www.jsit2013.com

・Educational Lecture 2・Luncheon Seminar 2

Theme:・Oral / Poster presentation“To explore the vision of Immunotoxicology”

・Workshop

The subject matter of the 20th Anniversary Annual・Awards Ceremony

Meeting of the Society is “To explore the vision ofImmunotoxicology” Although the details of the 20thMemorial Lectures as well as Symposium are being

20th Anniversary

日本免疫毒性学会20周年記念
Japanese
Society of Immunotoxicology

prepared now, the contents should be apposite forthe 20th anniversary, including invited speakers fromoverseas.
In addition, educational lectures on two separate subjects
are also included in the plan.
Lecture 1 will be on “Epigenetics of the function andNew with old in immunotoxicological research---- What has been and what shall be in JSIT
Motoyasu Ohsawa（Hatano Research Institute, Food and Drug Safety Center,

differentiation of immune-competent cells-aspects

Hadano, Japan）

of immunotoxicology”, while Lecture 2 willdeal with“Higher-order function analysis of the system ofNotch/NotchL in the development and differentiationof the immune system”.

Society followed with some suggestions about its

Prof. Kou Sakabe, Tokai University School of Medicine
Secretariat:
Hayato Terayama, Tokai University School of Medicine
FAX: +81-463-92-7440
e-mail：jsit20@tsc.u-tokai.ac.jp
Deadline for abstract submissions: July 19, 2013

Society of Immunotoxicology（JSIT）in 2013, hereis provided a historical information on founding ourPresident:

Phone: +81-462-93-1121 (ext. 2513/2514)

To w a r d s t h e 20 t h a n n i v e r s a r y o f T h e J a p a n e s efuture challenges. Three topics are described: A brief
history of 1）immunotoxicology before founding theresearch association in Japan and 2）foundation of theimmunotoxicology research association and subsequentestablishment of JSIT, and 3）some suggestions onfurther challenges of our Society at the 20th anniversary.
After immunotoxicology emerged and developed,immunotoxicologists in Japan founded their research
association in 1994, much later than in Europe and theUnited States. The association was aimed at sharing
novel concept of the young science and promoting

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ImmunoTox Letter
research activities of them. Their collaboration

IgA (HIGA) mice. It is suggested that fluoride induces

contributed to making good and rapid progress inimmunotoxicities in the mice with renal impairment.

researches, and subsequently developed to establish

In addition, I participated in the study evaluating theJSIT. JSIT is a unique organization specialized for

toxicity of multi-walled carbon nanotubes (MWCNT). My

immunotoxicology that investigates interactions between

role in the study was the evaluation of mRNA expressions

xenobiotics and hosts beyond conventional concept ofin splenocytes after whole body inhalation of MWCNT.

immunity or toxicity. It is suggested finally that for

Relative mRNA expression of IL-1β in macrophages

further challenges to unsolved and emerging problemsfrom the female rats exposed to 5 mg MWCNT/m 3

in immunotoxicology, JSIT should reasonably organize

was significantly higher than in control rat cells. For

projects and contribute to promoting international

lymphocytes, the cells from male and female rats in thecollaboration with own original perspectives, methods,

MWCNT-exposed groups had significantly lower IL-2and proposals.

values than control rat cells. These results suggested
that the immunotoxic effects are induced by whole bodyinhalation of MWCNT.
I continues the study of immunotoxicology as Researchシリーズ
Young powerfor immunotoxicological research9「免疫毒性研究の若い力」

assistant at Department of Public Health and EnvironmentalMedicine, The Jikei University, School of Medicine.

Immunotoxicology and my life
Takamasa Kido
(Department of Public Health and Environmental Medicine,

Words from new councilors

The Jikei University, School of Medicine)During my graduate student days in the master

Accession to the Board

course at Kitasato University Graduate School of

Yoshihiro Takahashi

Medical Sciences, I focused on the immunotoxicity of（Shin Nippon Biomedical Laboratories, Ltd.

petroleum-derived cleaning solvent for dry cleaning inDrug Safety Research Laboratories）

in vitro study. The use of a petroleum-derived cleaning
solvent for dry cleaning, instead of tetrachloroethylene

I wish to express my profound gratitude to those(perchloroethylene, PCE), has increased. The toxic

of my professors and seniors who recommended myeffects of the cleaning solvent have been considered low,appointment to the committee of the Japanese Society ofhowever, the solvent may cause dermatitis. The mRNA

Immunotoxicology.

expressions of cytokines related to inflammation andMy experience in the field of immunology began whenallergy in J774.1 cells exposed to the cleaning solvent

I was researching cytokine analysis and proliferativeor PCE were examined. The mean mRNA expressions

reaction using lymphocytes in human peripheral bloodof TNF-α and IL-1β in the 50μg/ml group wereand cedar pollen allergens for a Master’s degree. I am

significantly higher than those in the control. For PCE,currently engaged as a study director for drug safety

the mean expressions of IL-6 and IL-10 in the 800μg/ml

research. I am principally responsible for studies into

group were significantly higher than that in the control.

immunotoxicity, skin sensitization, and irritancy, andThe productions of IL-1β and TNF-α may be altered inhave spent several years working in areas that included

human during intoxication of the cleaning solvent as wellefficacy and general toxicity studies. General toxicity

as those of IL-6 and IL-10 in human during that of PCE,

studies cover a range that includes research intoand these may affect on immune cells.

effects on antibody production and immune function.

I also studied immnotoxicity of fluoride, the environmental

My involvement in these studies has granted me thepollutant, by using the mice with renal impairment suchopportunity to become acquainted with a number

as ICR-derived glomerulonephritis (ICGN) mice or Highof society members. Ordinarily, once a project has

No.1（14） 14

Vol. 18 No. 1 (2013)
been completed, there is little chance of being able toassociate with one’s collaborators, but the opportunities
for meeting and discussing our work that this society
provides researchers are extremely valuable.
Among the society’s meetings, that in which I
was privileged to make a presentation to the “JointResearch for the Investigation of Procedures for theEvaluation of Immunotoxicity of Pharmaceuticals”
workshop, which was held during the seventh annual
meeting, is particularly memorable. I was involved in
the compilation of chemical compounds and received
assistance from my seniors that went far beyond what
could be reasonably expected, and I wish to express mygratitude for their kindness.
Recently, SNBL has been conducting research into drug
efficacy, and in particular, there has been an increasing
demand for infection studies. Following the initiation ofthese we have gradually established a framework for suchundertakings. I will be delighted to hear from anyone whois interested in this field and look forward to working
alongside them.
Finally, I look forward to contributing to the developmentof the Japanese Society of Immunotoxicology, and morethan ever, I look forward to your continued assistanceand generous encouragement.

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