The 22nd Annual Meeting of JSIT
Special Lecture
The Influence of Early
Immune Signaling and theMicrobiome on
Immunomodulatory
Responses
following Exposure to the
Antimicrobial Triclosan

Stacey E. Anderson,
Jennifer Franko, Ewa
Lukomska, B. Jean Meade, NIOSH, Morgantown, WV,
Carrie Long, Nikki B.
U.S.A.
MarshallMaster’s Lecture１
Stress Signaling andDisease

Laboratory of Cell Signaling,
Hidenori Ichijo

Graduate School of
Pharmaceutical Sciences, U.
Tokyo

Master’s Lecture 2
Airborne fine particles andallergic rhinitis: Elucidationof allergic rhinitis
exacerbation mechanismand the development oftherapeutic techniques
using mouse model of(1) Department ofTomohiro Yoshimoto(1,2)

allergic rhinitis

Immunology, (2) Laboratoryof Allergic Diseases,
Institute for Advanced
Medical Sciences, Hyogo
College of Medicine

Symposium “‘Toxic’effect to‘disrupting’effect”
Organizer
Hirohisa Takano（Kyoto University）
Takamichi Ichinose （Oita University of Nursing and Health Sciences）
Kyoko Itoh（Kyoto Prefectural University of Medicine）
Aggravating effects ofAsian sand dust and PM2.5
on lung inflammation andallergic inflammation

Takamichi Ichinose(1),Miao He(2), KanaeBekki(3), YasuhiroYoshida(4), Cuiying He(4),Seiichi Yoshida(1), KaoriSadakane(1), Hirohisa
Takano(5)(1)Department of Health
Sciences, Oita University ofNursing and Health
Sciences., (2)Department ofEnvironmental andOccupational Health, Collegeof Public Health, China
Medical University.,(3)Department ofEnvironmental Health,National Institute of PublicHealth. , (4)Department of
Immunology andParasitology, School of
Medicine, University ofOccupational andEnvironmental Health.,(5)Department ofEnvironmental Engineering,
Environmental Health
Division, Graduate School ofEngineering, KyotoUniversity
Environmental chemicalinduced inflammatory
response and disruption ofCenter for Environmental
Eiko Koike

immune cell function

on obesity and obesityrelated metabolic disorders

Center for Environmental
Rie Yanagisawa

Health Sciences, Biological
Impact Research Section

Effects of prenatal andDepartment of Pathology

lactational exposure to
low-doses of bisphenol A
on murine brain

Institute for Environmental
Studies

Impact of exposure toenvironmental chemicals

Health Sciences, Nationaland Applied Neurobiology,
Kyoko Itoh, Shinji Fushiki

Graduate School of MedicalScience, Kyoto Prefecturaldevelopment

University of Medicine

Reproductive andendocrine disruption
induced by environmental
chemicals

Okazaki Institute forIntegrative Bioscience,
National Institute for Basic
Biology, National Institutesof Natural Sciences

Taisen Iguchi

Workshop: 「Immunotoxicity testing Q and A」
Organizer
Shigeru HisadaT(Research and Development Division, ASKA Pharmaceutical Co.,Ltd.)
Tadashi Kosaka (Study Management Division, The Institute of Environmental
Toxicology)
Current status of flow
cytometry measurement at
clinical laboratories -To
Atsushi Momobayashi
think about non-clinicalmeasurement itemsImmunologic tests andevaluation of the risk forchemical-induced
autoimmunity induced bychemicals in human

Minoru SatohMolecular Genetic Analysis
Department, LSI MedienceCorporationDepartment of ClinicalNursing, School of Health
Sciences, University ofOccupational andEnvironmental Health

Takumi Ohishi(1),Junichiro Sugimoto(2),A case of evaluation of theAkira Okamuro(2), Ryo
immunotoxicity data(1) Gotemba Laboratory, (2)Ando(1), Kenichi
having wide variations
Kannami Laboratory, BoZo
Fujisawa(1), Hidekazu
such as the production of
Research Center Inc.
Houri(1), Yuya Yasuda(1),antibody
Masahiro Mochizuki(1),Ken Goto(1)Appropriate trial Plan andanalysis method for TDAR

Satoru Fukinbara(1,2),
Osamu Komiyama(1,3),
Hideki Suganami(1,4),
Satoru Tsuchiya(1,5)(1) Data Science Expert
Committee, Drug Evaluation
Committee, JPMA, (2) Data
Science Development
Headquarters, Ono
Pharmaceutical Co., LTD.,(3) Statistics and Clinical
Programming, Development

Japan, Pfizer Japan Inc., (4)Data Science Dept., Kowa
Co., Ltd., (5) S Biostatistics
group, Data science,
Sumitomo Dainippon
Pharma, Co., Ltd.
Award Lecture: The 6th JSIT Award (for Distinguished Contribution)
Effects of genetic
polymorphisms on anticancer drug-indued

Jun-ichi Sawada

Pharmaceuticals and MedicalDevices Agency

myelotoxicity
Award Lecutre: The 6th Research Award(1) Laboratory of Vaccine
mechanisms of particulateinduced immune responses Etsushi Kuroda(1), Ken J
and inflammations Ishii(1,2)
Particulate adjuvant andimmunotoxicity-Science, WPI Immunology
Frontier Research Center,
Osaka University, (2)Laboratory of Adjuvant
Innovation, National
Institute of Biomedical
Innovation, Health andNutrition

Impact of environmental
pollutants on lifestyle
related diseases -from thepoint of view of
immunotoxicology-

Rie Yanagisawa

Center for Environmental
Health Sciences, Biological
Impact Research Section

Qing Li, Maiko Kobayashi,
Tomoyuki Kawada

Department of Hygiene andPublic Health, Nippon
Medical School

Naoko Kunagai-Takei(1),Yasumitsu Nishimura(1),Analysis for mechanism of Hidenori Matsuzaki(1),effect of asbestos exposure Suni Lee(1), Kei(1) Department of Hygiene,

The underlying

Oral Presentations
Effects of carbamate
pesticides on natural killer(NK) activity

on CTL function

Yoshitome(1), Hiroaki
Hayashi(2), Takemi(2) Department ofDermatology, Kawasaki
Medical SchoolOtsuki(1),Vacuole formation and cell
death of monocytes
exposed to titanate
nanosheet

Yasumitsu Nishimura(1),Daisuke Yoshioka(2), SuniLee(1), Naoko KumagaiTakei(1) Hidenori
Matsuzaki(1), Kei
Yoshitome(1), Takemi
Otsuki(1)(1( Department of Hygiene,(2) Department of NaturalSciences, Kawasaki MedicalSchool(1) Laboratory of Vaccine
Particulates induce uniquelung immune responses
and promote tertiary
lymphoid organs in thelung

Etsushi Kuroda(1), Ken J
Ishii(1,2)

Science, WPI Immunology
Frontier Research Center,
Osaka University, (2)Laboratory of Adjuvant
Innovation, National
Institute of Biomedical
Innovation, Health andNutrition

Akiko Honda(1), Takahiro
Sawahara(1), Tomohiro
Effects of biological andchemical factors adhered
to Asian sand dust
particles on respiratory
and immune system

Hayashi(1), Kenshi
Tsuji(1), Wataru
Fukushima(1), Mizuki
Oishi(1), Gaku
Kitamura(1), Hitomi
Kudo(1), Sho Ito(1),Seiichi Yoshida(2),Takamichi Ichinose(2),Kayo Ueda(1), Hirohisa(1) Department ofEnvironmental Engineering,Environmental HealthDivision, Graduate School ofEngineering, Kyoto
University, (2) Department
of Health Sciences, Oita
University of Nursing and
Health Sciences.

Takano(1)Effects of aging, radiation,

Tomonori Hayashi(1),Kengo Yoshida(1), Yukari
Morishita(1), Hiroko

and genetic background on Nagamura(1), Keikointracellular ROS levels inSasaki(1), Mayumi
atomic-bomb survivors
and mice

Epidemiology, Radiation
Effects ResearchMaki(1), Keiko Furudoi(1), Foundation, (2) Hiroshima
Ikue Hayashi(2), Seishi
University Faculty ofKyoizumi(1), Yoichiro
Kusunoki(1)Gene expression ofinflammatory cytokines(1) Department ofRadiobiology/Molecular

Kido Takamsa(1), Takumi

Dentistry, Hiroshima(1) Department of Public
Health and Environmental

Medicine, Jikei University
and chemokines in spleen Shota(1,2), Yogosawa
School of Medicine, (2)macrophages derived from Shingo(1), Suga Machi(1),Department of Domestic
Zn-deficient and Zn-excess Yanagisawa Hiroyuki(1)Science, Kagoshimarats
Women’s CollegeEffects of biochanin A oninterleukin-17 gene
expression through STAT3
activation

Association of a HLA typewith statin-related
Japanese myopathy
patients

Hiroyuki Kojima(1), Ryuta
Muromoto(2), Miki
Takahashi(2), ToruHirao(2), Tadashi
Matsuda(2)Kimie Sai(1), KojiKajinami(2), Hiroyoshi
Akao(2), TakuyaImatoh(1), YumikoMatsuzawa(1), Keiko
Maekawa(1), Japan PGxData Science(1) Department of FoodSciences, Hokkaido Instituteof Public Health, (2)Graduate School of
Pharmaceutical Sciences,
Hokkaido University(1) National Institute of
Health Sciences, (2)Kanazawa MedicalUniversity, (3) JPDSC

Consortium(3), Yoshiro
Saito(1)Skin sensitization model by
quantitative structureactivity relationships(QSAR) based on EC3
value

Kazuhiro Sato(1), Kohtaro
Yuta(2), Jose Martin
Ciloy(3), Yukinori
Kusaka(1)(1) Department ofEnvironmental Health,
School of Medicine,
University of Fukui, (2) In
Silico data Co Ltd., (3)Fujitsu Kyushu Systems
Limited (FJQS)

Effects of functional

Seishiro Hirano(1), Sanae(1) Center forchanges in lysosomes on
intracellular behavior ofKanno(2)Environmental Risk
Research, Natl. Inst.

LC3 in J774.1 cells

Environ. Studies, (2) St.

Marianna Univ. School ofMedicine
Students and Young Scientists Session (Oral and Poster Presentations)
Sho Ito, Takahiro
Sawahara, Tomohiro
Effects of food components
Hayashi, Wataru
on airway inflammation
Fukushima, Gaku
induced by diesel exhaust
Kitamura, Hitomi Kudo,
particles
Akiko Honda, Kayo Ueda,
Hirohisa Takano

Department ofEnvironmental Engineering,
Environmental Health
Division, Graduate School ofEngineering, KyotoUniversity

Thymic stromal

Yasutaka Kuroda(1,2),(1) Safety Science ResearchLaboratories, Kaolymphopoietin is inducedby protein and chemical

Takuo Yuki(1), YutakaTakahashi(1), Hitoshi

Corporation, (2) Departmentof Material Science andallergens in cultured
human keratinocytes

Sakagushi(1), Hiroshi
Itagaki(2)Engineering, Faculty ofEngineering, Yokohama
National University

Application of
Hydroxypropyl-bcyclodextrin, a small
compound as a potent
DAMPs inducer, for(1) Laboratory of Adjuvant
Innovation, NationalInstitute of Biomedical
Takato Kusakabe(1,2),
Etsushi Kuroda(2), Ken J

Innovation, Health andNutrition (NIBIOHN), (2)Ishii(1,2)

Laboratory of Vaccine
Science, Immunology

mucosal adjuvant

Frontier Research Center(IFReC), Osaka University

Poseter Presentations
Analysis of plasma
immunoglobulin and BAFF

Suni Lee, Yasumitsu
Nishimura, Shoko(B cell activating factor
belonging to the tumor

Yamamoto, Tamayo
Hatayama, Hidenori

necrosis factor family) in
non-autoimmune disease
onset silicosis patients

Matsuzaki, Naoko
Kumagai-Takei, Takemi
Otsuki

Kawasaki Medical School,
Dept. Hygiene(1) Department of Hygiene,

Effect of long-term
exposure of asbestos ontranscription factor FoxP3

Hidenori Mastuzaki(1),Suni Lee(1), Megumi
Maeda(2), Naoko
Kumagai-Takei(1),Yasumitsu Nishimura(1),Takemi Otsuki(1)Kawasaki Medical School,(2) Laboratory of Functional
Glycobiochemistry,
Department of BiofunctionalChemistry, Division ofAgricultural and Life
Science, Graduate School ofEnvironmental and Life
Science, Okayama
University

Acetamiprid affect thevarious gene expressions
in murine testis, with

Hayato Terayama(1),Hitoshi Endo(2), Teruhisa
Kanazawa(1), Masayuki(1) Department of Anatomy,e, (2) Department ofCommunity Health, Tokai

special reference toimmune disruptive effectTatemichi(2), KouSakabe(1)University School ofMedicine

Synergistic augmentation

Daigo Sumi, ◯Hitomi

Faculty of Pharmaceuticalof ATP-induced interleukin- Fujishiro, Masashi Asao,
6 production by arsenite in Hideta Okada, Kuniko
HaCaT cells

Sciences, Tokushima BunriUniversity

Yogi, Hideki Miyataka,Seiichiro Himeno
Electron microscopic
observation of a novel
cytoplasmic rods and rings
structure recognized byautoantibodies frompatients with chronic
heapatitis C viral infection(1) Department of Human,Information and Life
Tamiji Nakashima(1), Shin Sciences, (2) Department
Tanaka(1), Minoru
Satoh(2)of Clinical Nursing, School ofHealth Sciences, Universityof Occupational andEnvironmental Healthtreated with ribavirin.
Studies on improving drug
tolerance in assay for anti- Kazuko Nishimura, Akiko

Division of Biological
Chemistry and Biologicals,

drug antibody against
biopharmaceuticals

Ishii-Watabe

National Institute of HealthSciences

Hideki Harada, Yui

Safety Assessment

Akagawa, Kazumori Endo,
Yusuke Tamukai, Daisuke

Department, Group C,
Nonclinical Research Center,Minami, Hiroyuki Ishii,

Drug Development ServiceYasuyuki Onishi, Hideaki
Hiratsuka

Segment, LSI Medience
Corporation

Characterization of basic
immunoreactivity inGöttingen miniature pigs

Junichiro Sugimoto(1),Evaluation ofAkira Okamuro(1), RyoAndo(2), Kenichi

immunotoxicological effect(1) Kannami Laboratory, (2)Fujisawai(2), Hidekazu
used for lymphocyte
Gotemba Laboratory, BoZo
Houri(2), Yuya Yasuda(2),subset examination along
Research Center Inc
Ken Goto(2), Masahirowith TDAR assay
Mochizuki(2), Takumi
Ohishi(1)(1) Department of Safety
Research on Blood andBiologicals products,, (2)Department of Bacteriology
II, Institute of Infectious
Diseases, (3) National
Establishment for a next
generation safety
evaluating method for
influenza vaccine andadjuvants using
humanized mouse model

Eita Sasaki(1), Takuo
Mizukami(1), Haruka

Institutes of Biomedical
Innovation, Health andMomose(1), Kazunari

Nutrition. Toxicogenomics

Kamachi(2), Hiroshi

and Informatics Project, (4)Yamada(3), Ken J
Ishi(4,5), Isao

National Institutes ofBiomedical Innovation,

Hamaguchi(1)Health and Nutrition.
Laboratory of Adjuvant
Innovation, (5) Laboratoryof Vaccine Science,
Immunology FrontierResearch center, OsakaUniversity.

IgE crosslinking-induced

Ryosuke Nakamura(1),(1) Division of Medicinal

luciferase expression(EXiLE)-based analysis ofYoshimi OkamotoUchida(1), Yumiko

Safety Science, (2) Divisionof Biological Chemistry andIgE epitopes of modelMatsuzawa(1), Akiko

Biologicals, National

allergenIshii(2), Yoshiro Saito(1)Institute of Health Sciences

Investigation of allergy

Kunihiko Yamashita(1,3),(1) Corporate Research

inducing potential of

Shinsuke Shinoda(2),Center, Daicel Corporation,(2) Yoshimi Laboratories,

benzalkonium chloride
using LLNA:DAE method

Saori Hagiwara(2), Hiroshi Drug Safety Testing Center
Itagaki(3)Co., Ltd., (3) Faculty ofEngineering, Dept. ofMaterials Science andEngineering, Yokohama
National University

Impact of exposure toimmunosuppressive

Risako Nishino, Tomoki
Fukuyama, Yuko

chemicals on the next-Watanabe, Hideo Ueda,

generation respiratory

Tadashi Kosaka, Takanoriallergy

HaradaThe Institute ofEnvironmental Toxicology(1) Department of Hygiene,
Takemi Otsuki(1),Experimental analyses ofthe effects of negativelycharged air-condition onhuman immune cells

Yasumitsu Nishimura(1),Megumi Maeda(2), Naoko
Kumagai-Takei(1), Suni
Lee(1),Hidenori
Matsuzaki(1), Kei
Yoshitome(1)Kawasaki Medical School,(2) Laboratory of Functional
Glycobiochemistry,
Department of BiofunctionalChemistry, Division ofAgricultural and Life
Science, Graduate School ofEnvironmental and Life
Science, Okayama University

Luncheon Seminar 1
Pharmacodynamic and In
Vitro Functional
Immunoassays in Supportof Preclinical and ClinicalOncology(1)Director, Laboratory
Christina Satterwhite(1) ,Sciences, Charles River,Marie-Soleil Piché(2)(2)Scientific Director,
Immunology, Charles River

BiopharmaceuticalPrograms(1)Manager, Discovery &Safety Assessment Sales,
The latest requirement foranimal housing in the EU

Hiroyuki Minami(1) ,Sachihiko Okubo(2)Charles River, (2)Sales
Specialist, Discovery &Safety Assessment Sales,Charles River

Luncheon Seminar 2
Immunological Aspects ofImmunogenicity

Gregory Bannish

Huntingdon Life Sciences