The 21st Annual Meeting of JSIT
Special LectureⅠ
Immunogenicity
assessment ofbiotechnology-derived
pharmaceuticals

Marc Pallardy

Toxicology Department andINSERM UMR 996, Faculty ofPharmacy, University Paris-Súd,
FranceTatsuyoshi Kawamura

University of Yamanashi,
Department of Dermatology

Special Lecture Ⅱ
The mechanisms for zinc
deficiency-associateddermatitis
Master’s Lecture
Molecular pathogenesis ofYoshiyuki Minegishi
hyper-IgE syndrome

Division of Molecular Medicine,
Institute for Genome Research,
The University of Tokushima

Symposium “Next-generation Approach in Immunotoxicology”
Organizers
Yasumitsu Nishimura (Kawasaki Medical School)
Ryosuke Nakamura (National Institute of Health Sciences)
Eiko Koike (National Institute for Environmental Studies)
Yasuo Yoshioka (Graduate School of Pharmaceutical Sciences, Osaka University)
Dynamics of complex
biological systems
determined/controlled by Atsushi Mochizuki(1)minimal subsets ofmolecules in regulatory
networks(1)Theoretical Biology Laboratory,RIKEN, (2)Department ofand Bernold Fiedler(2) Mathematics, Free University ofBerlin, Germany

Chemical Strategy fordirect and indirect
detection of protein-smallNaoki Kanohmolecule interactions:
Drug target discovery andP450 substrate screening

Graduate School of
Pharmaceutical Sciences, Tohoku
University

A novel role of spleenderived IL-10 in obesityinduced systemic
inflammation

Department of Endocrinology,Metabolism, Rheumatology andNephrology, Faculty of Medicine,
Oita University

Koro Gotoh, Hirotaka
Shibata

New mechanism of action
and potential biomarkers Ken J Ishii(1),(2)for vaccine adjuvant(1)Laboratory of Adjuvant
Innovation, National Institute of
Biomedical Innovation,(2)Laboratory of Vaccine Science,Immunology Frontier ResearchCenter, Osaka University

Workshop: Immunotoxicology Methods “ Toward the development of new test
methods for xenobiotic-induced allergy and autoimmune diseases ”

Autoimmune disorders
and side-effects via
immune systems that are
Tomoaki Inouecaused by administering
biotechnology-derived

Safety Assessment Department,
Research Division, Chugai
Pharmaceutical Co., Ltd.

pharmaceuticals
Splenic lesion in rats
treated with antithyroid

Motoko Fukui(1) ,(1)Safety Research Department,

drugs –suggestive auto-Mitsui isobe(1),(2)Developmental Research

antibody production

Shigeru Hisada(2)Center, ASKA Pharmaceutical Co.

Animal model of
immediatehypersensitivity inducedby transdermal

Reiko Adachi, Shinobu National Institute of Health
Sakai, Reiko Teshima Sciences

administration of foodallergenThe study of detection
method for particulate
environmental chemicalinduced respiratory
allergy

Risako Nishino,
Tomoki Fukuyama,
The Institute of Environmental
Yuko Watanabe, Hideo
Toxicology
Ueda, Tadashi Kosaka,
Takanori HaradaAward Lecture
Immunotoxicity ofenvironmental substanceswith special reference to Motoyasu Ohsawa(1),heavy metals:(2)
Toxicological properties
and evaluation(1)Hatano Research Institute,
Food and Drug Safety Center,(2)Teikyo University

Oral Presentations

ell death of peripheral
blood mononuclear cells
caused by exposure totitanate nanosheet

Yasumitsu
Nishimura(1), Daisuke
Yoshioka(2), Suni
Lee(1), Hidenori
Matsuzaki(1), Naoko
Kumagai-Takei(1), Kei
Yoshitome(1), Takemi
Otsuki(1)Particulate-induced IgE
Etsushi Kuroda(1),production is mediated by
Yasuo Morimoto(2),DAMPs from alveolar
Ken J Ishii(1),(3)macrophages

The transitivity andbiological effects of silver
nanoparticles to infants
through the milk

Yasuo Yoshioka(1),(2), Yuki Morishita(1),Yuya Takimura(1),Shin-ichi Tsunoda(2),(3), Kazuma
Higashisaka(1),(2),Yasuo Tsutsumi(1),(3)(1)Department of Hygiene,(2)Department of NaturalSciences, Kawasaki MedicalSchool(1)WPI Immunology Frontier
Research Center, Osaka
University, (2)University ofOccupational and EnvironmentalHealth, (3)National Institute of
Biomedical Innovation(1)Graduate School of
Pharmaceutical Sciences, Osaka
University, (2)National Institute of
Biomedical Innovation, (3) MEIC,Osaka University

Phagocytosis of Indium
Tin Oxide Nanoparticles
by Alveolar Macrophages
triggers a proinflammatory response
Suppressive effect ofsakuran against IL-13, IL33, Filaggrin and TNFalpha in TNCB-induced
mice
Impact of sex-differenceson scratching behavior
with pruritus induced bypruritogens in mice
Skin sensitization study
from only animal data bystructure-toxicityrelationships (QSTR)
approachTranslocation ofMacrophage Receptor
with CollagenousStructure (MARCO) toautophagosomes

Basilua Andre
Muzembo, Abderrahim
Naji and Narufumi
SuganumaRyoji Hirota(1),Nlandu Roger
Ngatu(2), Maiko K
Okajima(3), Tatsuo
Kaneko(3), Narufumi
Suganuma(1)Katsunori Yamaura,

Department of Environmental
Medicine, Kochi University, Kochi
Medical School(1)Department of Environmental
Medicine, Kochi Medical School,(2)Graduate School of Health &Nursing Sciences University ofKochi, (3)Department of Materials
Science, Japan Advanced Instituteof Science and Technology
Graduate School of

Ayana Tomono, Hiromi Pharmaceutical Sciences, Chiba
Sato, Koichi Ueno

University

Kazuhiro Sato(1),Yukinori Kusaka(1),Kohtaro Yuta(2)(1)Deaprtment of Fukui, School ofMedicine, University of Fukui,(2)In Silico Data Ltd.

Seishiro Hirano(1),Sanae Kanno(2)(1)National Institute forEnvironmental Studies, (2)St.
Marianna University School ofMedicine

Effects of intratracheal
exposure to bisphenol A
Eiko Koike(1), Rieon the immune system
Yanagisawa(1), Tin
and central nervous
Tin Win Shwe(1),system in a murine model
Hirohisa Takano(2)of allergic airway
inflammation(1)National Institute forEnvironmental Studies, (2)Kyoto
UniversityTomonori Hayashi(1),Yiqun Hu(1), Yukari
Morishita(1)、Keiko
Sasaki(1)、Mayumi
Functional significance ofMaki(1)、Keiko
Furudoi(1)、Hiroko

Departments of(1)Radiobiology/MolecularIL6R genotype andcolorectal cancer risk bygenotype among atomic-Nagamura(1), KengoYoshida(1), Junko
Kajimura(1), Waka

Epidemiology and (2)ClinicalStudies, Radiation Effects
Research Foundation,bomb survivorsOhishi(2), Ayumi
Hida(2), Ikue(3)Hiroshima University Faculty ofDentistryHayashi(3), Seishi
Kyoizumi(1), Yoichiro
Kusunoki(1), KeiNakachi(1)Students and Young Scientists Session (Oral and Poster)
Effects of components ofPM(2).(5) on bronchial

Wataru Fukushima,
Mizuki Oishi, Akiko

epithelium cells andimmune cells

Honda, Kenshi Tsuji,
Takahiro Sawahara,
Tomohiro Hayashi,

Graduate school of Engineering
Kyoto University

Hitomi Kudoh, KayoUeda, Hirohisa Takano
Toshiro Hirai(1), YasuoYoshioka(1),(2), Koichi Ichihashi(1),The effects of metal

Natsumi Izumi(1),Nobuo Nishijima(1),(1)Graduate School of
Pharmaceutical Sciences, Osaka

nanoparticles on onset ofmetal allergy

Takayuki Handa(1),Hideki Takahashi(1),University, (2)National Institute of
Biomedical Innovation, (3)MEIC,

Shin-ichi Tsunoda(2),(3), Kazuma

Osaka University

Higashisaka(1),(2),Yasuo Tsutsumi(1),(3)
Yoshimi Uchida(1),Nahoko Kaniwa(1),Mayumi Ueta(2),Ryosuke(1)National Institute of HealthSciences, (2)Kyoto PrefecturalNakamura(1), Emiko
Medication tendencies for Sugiyama(1),University of Medicine,(3)Shizuoka Institute of Epilepsy

inducing acute severe
ocular complications inJapanese Stevens-and Neurological Disorders,(4)Kochi University, Medical
School, (5)Fujita HealthYukitoshi
Takahashi(3),Hirokazu Furuya(4),Johnson syndrome / toxic Akiko Yagami(5),University, School of Medicine,
epidermal necrolysis
Setsuko Matsukura(6), (6)Yokohama City University,
patients

Zenro Ikezawa7,
Graduate School of Medicine,
Kayoko Matsunaga(5), 7International University ofChie Sotozono(2),Michiko Aihara,
Shigeru Kinoshita(2),Health and Welfare, Atami
Hospital

Yoshiro Saito(1)Preventive effect of thehistamine H(4) receptor
antagonist on worseningof itching induced bylong-term topicalglucocorticoid treatment
Effect of oxidized olive oilon mouse lymphocytes
and peritoneal
macrophages

Seiji Onuma,
Katsunori Yamaura,
Nobuo Oishi, Ayaka

Department of GeriatricPharmacology and Therapeutics,
Graduate School ofFunakoshi, Hiromi
Sato, Koichi Ueno

Pharmaceutical Science, Chiba
University

Hirofumi Ogino, Chisa
Betto, Ai Minami,
Tomohiro Arakawa,
Tomofumi Okuno,

Faculty of PharmaceuticalSciences, Setsunan University

Hitoshi Ueno

Poseter Presentations
Effects of maternal

Amika Yoshida(1),exposure to carbon black
nanoparticle on the lung

Atsuto Onoda(1),Pharmaceutical Sciences, Tokyo
Yoichiro Yoshikawa(1), University of Science, (2)The(1)Graduate School ofof mother and the splenic Ken Takeda(2),phenotype of offspring
Masakazu

Center for Environmental Health
Science for the Next Generation,mouse

Umezawa(2)RIST, Tokyo University of Science

Analysis between plasma

Suni Lee, Yasumitsu

Department of Hygiene, Kawasaki

DcR(3) andautoantibodies or

Nishimura, Shoko
Yamamoto, Tamayo

Medical School

respiratory score in nonautoimmune disease

Hatayama, Hidenori
Matsuzaki, Naoko

onset silicosis patients

Kumagai-Takei, Kei

Yoshitome, Takemi
OtsukiEffect of long-term

Hidenori Matsuzaki(1), (1)Department of Hygiene,Suni Lee(1), Megumi Kawasaki Medical School,Maeda(2), Naoko(2)Department of Biofunctional

exposure of asbestos onhuman T cell line MT-2

Kumagai-Takei(1),Yasumitsu

Chemistry, Division of Bioscience,
Okayama University Graduate

Nishimura(1), Takemi
Otsuki(1)School of Natural Science andTechnology

Takemi Otsuki, Naoko
Long-term monitoring forTakei, Hidenori
immunological effects ofMatsuzaki, Suni Lee,negatively charged indoor
Kei Yoshitome,
air environment
Yasumitsu Nishimura

Department of Hygiene, Kawasaki
Medical School

Risako Nishino,
Tomoki Fukuyama,

The effect of mast cell on
Yuko Watanabe,
the respiratory allergy
Yoshimi Kurosawa,
caused by environmental
Hideo Ueda,
particulate matter
Tadashi Kosaka,
Takanori Harada

The Institute of Environmental
Toxicology

RyosukeNakamura(1), Nahoko
Kaniwa(1), Mayumi
HLA association with
antipyretic analgesics-Ueta(2), Chie
Sotozono(2), EmikoSugiyama(1), Keikorelated Stevens-Johnsonsyndrome / toxic

Maekawa(1), YoshimiUchida(1), Akiko

epidermal necrolysis withacute severe ocularYagami(3), Setsuko
Matsukura(4), Zenro

complications in theJapanese population

Ikezawa(5), Kayoko
Matsunaga(4),(1)National Institute of HealthSciences, (2)Kyoto Prefectural
University of Medicine, (3) Fujita
Health University, School ofMedicine,(4)Yokohama City
University, Graduate School ofMedicine, (5)International
University of Health and Welfare,
Atami Hospital, (6)University ofTokyo, Graduate School of
Katsushi Tokunaga(6),Medicine
Michiko Aihara(4),Shigeru Kinoshita(2),Yoshiro Saito(1)Hayato Terayama(1),Kou Sakabe(1),Low-dose di-((2)-

Shuichi Hirai(2),Munekazu Naito(3),ethylhexyl) phthalate
Ning Qu(2), Miyuki(DEHP) exposure
Kuramasu(2), Yuki
increases susceptibility to Ogawa(2), Naoyuki
testicularautoimmunity in mice

Hatayama(2), Shogo
Hayashi(2), Yuko
Furuya(1), Teruhisa
Kanazawa(1),(1)Department of Anatomy,
Division of Basic Medicine, Tokai
University School of Medicine,(2)Department of Anatomy, Tokyo
Medical University, (3)Departmentof Anatomy, Aichi MedicalUniversity

Masahiro Itoh(2)Allergy to formaldehyde:

Yusuke Tanaka(1),(1)Division of Respiratory

basophil histaminerelease test is useful for

Yuko Nakase(1),Naoya Sugimoto(1),Medicine and Allergology,
Department of Medicine,diagnosis

Sayaka Igarashi(1),Hidenori Arai(1),(2)Department of Plastic, Oraland Maxillofacial Surgery, TeikyoKenshin Ohara(2),University School of Medicine,Hiroyuki Nagase(1),(3)National Hospital Organization

Masao Yamaguchi(1),Ken Ohta(1),(3)Tokyo National HospitalSpecificity ofautoantibodies in patientswith rheumatologic
syndrome following
mineral oil injections andin mice with adjuvant

Minoru Satoh(1), Shin(1)University of Occupational andTanaka(1), Hajime
Environmental Health,Hori(1), Yoshiki(2)University of Miyazaki
Kuroda(2)mineral oil-inducedautoimmunity
Fluoride enhances theTakamasa Kido(1),(2),invasion of inflammatory

Masashi Tsunoda(2),macrophages into theChiemi Sugaya(2),renal tubulointerstitium of Hiroshi Hano(3),rats with unilateral
Hiroyukiureteral obstruction

Yanagisawa(1)The trial of mouse TDARKen Goto, Kenichi
Fujisawa, Hidekazu

method development forevaluation ofimmunotoxicity

Houri, Masahiro

and Environmental Medicine, TheJikei University School ofMedicine, (2)Department ofHygiene, Kitasato University
School of Medicine, (3)The Jikei
University School of Medicine

BOZO RESEARCH CENTER INC.

Mochizuki, Takumi
OhishiHaruka Akae(1), Nana

Study of the effect of(1)Department of Public Health

Hirashima(1), Nobuaki(1)Department of Pharmacology,(2)Department of PhysicalMatsui(1), Nobuyuki
Chemistry, Faculty ofFukuishi(1), Yoshiyasu
Pharmaceutical Sciences,bulbectomy mouse model Fukuyama(2), Masaaki
Tokushima Bunri University
Akagi(1)Magnolol in depression
using Olfactory

The role of signaltransduction molecules on
the regulation of c-Kit
expression on TGF-βtreated mast cells

Risa Hasegawa,Nobuyuki Fukuishi,

Department of Pharmacology,

Hayato Teruya,
Yousuke Hata, Mika

Faculty of PharmaceuticalSciences, Tokushima BunriYoshida, Masaaki

UniversityAkagi
Youhei Hiromori(1),Thymic adipogenesis(2), Noriyuki Sakai(1), (1)Gifu Pharmaceutical University,

induced by triphenyltin
impairs peripheral

Ryo Kobayashi(1),Daichi Jodai(1),lymphocyte populations

Tsuyoshi Nakanishi(1), University(2)Department of Pharmacy,
College of Pharmacy, Kinjo Gakuin

Hisamitsu Nagase(1)Effects of TNFa and IL-1β

Hitomi Fujishiro,
Tomoki Kitayama,

Faculty of PharmaceuticalSciences, Tokushima Bunri

Seiichiro Himeno

University

Effects of arsenite on theDaigo Sumi, Kumi

Faculty of Pharmaceutical

IL-2-induced NK cells
activation

Harada, Seiichiro
HimenoSciences, Tokushima Bunri
University

Arsenite impairs thefunction of natural killer

Daigo Sumi, Tomoko
Ogawa, Seiichiro

Faculty of Pharmaceutical
Sciences, Tokushima Bunri

cells

HimenoUniversity

Arsenite enhances IL-8

Daigo Sumi, Anna
Yamachika, Seiichiro

Faculty of PharmaceuticalSciences, Tokushima Bunri

HimenoUniversityon accumulation ofmanganese in SH-SY5Ycells

production in Jurkat cells

Luncheon Seminar (1)Reducing immunogenicity
in a T-cell dependent
antibody response(TDAR) in cynomolgus
monkeys leads to asensitive assessment ofimmunosuppression by
Abatacept (CTLA4-Ig)

Sylwia Marshall(1),Gregory Bannish(2),Meredith Perpetua(2),Tracy Ziegelhofer(2),John Doughty(2),Aidan Curran(2), Lee(1)Huntingdon Life Sciences,
Cambridgeshire, United Kingdom,(2)Huntingdon Life Sciences, East
Millstone, NJ, United States

Coney(1)Luncheon Seminar (2)Development of assays tomonitor theimmunotoxicity andefficacy of biotherapeutics

Marie-Soleil Piche

Science Director Immunology,
Charles River Laboratories