ཷク◊✲ᑂᰝጤဨ఍㆟஦ᴫせ㻌㻌㻌ጤဨ఍㛤ദ᪥㻌 䠖㻌 ᖹᡂ㻌 䠎䠎ᖺ㻌 䠕᭶㻌 䠍䠑᪥䠄Ỉ᭙᪥䠅㻌 㻝㻡 ᫬ 㻟㻜 ศ䡚㻝㻢 ᫬ 㻡㻜 ศ㻌఍㆟ሙ㻌 䠖㻌 ➨㻌 ୍㻌 ఍㻌 ㆟㻌 ᐊ㻌ฟᖍ⪅㻌 䠖㻌 Ώ㒊㻌 ᖾኵ㻔ጤဨ㛗㻕䚸㔠⏣㻌 ᝅ㑻䚸᳃㻌 ಇோ䚸␜㛫㻌 㔜ே䚸኱཭㻌 Ᏺ䚸㻌 ኱➉㻌 ᗣ཭䚸㙊⏣㻌 ⰋᏊ䚸㻌㛵ᕝ㻌 ⩏᫂䚸ᩪ⸨㻌 ᫭ᘯ䚸ᒣᮏ㻌 ᪼䚸ᑠᔱ㻌 ஂᏊ㻌㻌ጤဨ㛗䜘䜚䚸ᑂ㆟ཬ䜃᥇Ỵ䛾㝿䛿ᙜヱ἞㦂䛻㛵୚䛩䜛ጤဨ䛾㏥ᖍ䜢ồ䜑䜛᪨䛜ఏ䛘䜙䜜䛯䚹㻌㻌䠍㻌 ᪂つཷク◊✲㻌㻌㻔㻝㻕㻌➨୍୕ඹᰴᘧ఍♫䛾౫㢗䛻䜘䜛 AMG162䠄䝕䝜䝇䝬䝤䠅䛾䝯䝖䝖䝺䜻䝃䞊䝖䠄MTX䠅἞⒪୰㛵⠇䝸䜴䝬䝏ᝈ⪅䜢ᑐ㇟䛸䛧䛯⏝㔞཯ᛂヨ㦂䠄➨䊡┦䠅䛆ᑂ㆟஦㡯䛇㻌䛣䜜䜎䛷䛻ᚓ䜙䜜䛶䛔䜛⮫ᗋヨ㦂ᡂ⦼䛻ᇶ䛵䛝䚸἞㦂ᐇ᪋䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌㉁ 㻌 ␲ 㻌 ᛂ 㻌 ⟅㻌 䠖㻌 㻌ጤဨ㛗㻌 㻌 䠖ᮏ἞㦂䛾ᴫ␎ㄝ᫂䛒䜚䛜䛸䛖䛤䛦䛔䜎䛩䚹␲ၥⅬ䚸㉁ၥ䚸ఱ䛛䛤䛦䛔䜎䛩䛛䚹㻌 㻌 㻌 㻌 㻌 㻌 㻌 ᪥ᮏ䛷䛿䚸䝸䜴䝬䝏䛻㛵䛧䛶䚸Phase䊡䛸䛺䛳䛶䛚䜚䜎䛩䛜䚸ᾏእ䛷䛿䜒䛖⮫ᗋⓗ䛻౑䛳䛶䛔䜛䛾䛷㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛧䜗䛖䛛䚹୰ᒣ་ᖌ䠖䜎䛰䛷䛩䚹ᒣᮏጤဨ䠖㠀ᖖ䛻䝅䞁䝥䝹䛺㉁ၥ䛷䛩䛡䜜䛹䜒䚸㦵⢒㧼⑕䛸㛵⠇䛾◚ቯ䛸䝯䜹䝙䝈䝮䛿ྠ䛨䛷䛩䛛䚹୰ᒣ་ᖌ䠖ᙺ๭䜢ᢸ䛖䛾䛿䚸◚㦵⣽⬊䛷䛿䛺䛔䛛䛸ᛮ䛔䜎䛩䚹䝸䜴䝬䝏䛾ሙྜ䛻䛿䚸᭱ึ䛻ኚ໬䛜ฟ䛶䛟㻌 㻌 㻌 㻌 㻌 㻌 㻌 䜛䛾䛿䚸⾲㠃䛾⓶㉁㦵䛾㒊ศ䛜୺䛷䛒䜚䜎䛩䛜䚸㦵⢒㧼⑕䛾ሙྜ䛻䛿䚸䛭䛾㦵௦ㅰ䜢ᢚ䛘䜛㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛸䛔䛖ព࿡䛷䛿䚸⓶㉁㦵䜘䜚䜒ᾏ⥥㦵䛾㦵௦ㅰᅇ㌿䛜㠀ᖖ䛻㏿䛔䛾䛷䚸䛭䛱䜙䛛䜙䜒䜝䛟䛺䛳䛶㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛔䛟䛣䛸䛜ከ䛔䛷䛩䚹ᒣᮏጤဨ䠖䛚⪺䛝䛧䛯䛔䛾䛿䚸⾑⟶䛸䛾㛵ಀ䛷䛩䚹㦵⢒㧼⑕䛾ሙྜ䛿䚸ᾏ⥥㦵䛷䛩䛛䜙㠀ᖖ䛻⾑⟶䛜ศᕸ䛶䛔䜛䜟䛡䛷䛩䚹୰ᒣ་ᖌ䠖⾑⟶䛾␯䛾ᡤ䛻䜒ຠ䛟䛾䛛䛸䛔䛖䛣䛸䛷䛩䛽䚹䛣䛾䝕䝜䝇䝬䝤䛾ᾏእ἞㦂䜢ぢ䜎䛩䛸䚸ᐇ㝿䛻ຠ㻌 㻌 㻌 㻌 㻌 㻌 㻌 ᯝ䛿ฟ䛶䛔䜛䛾䛷䛩䛜䚸䛯䛰௒ᅇ౑䛖⏝㔞䜘䜚䜒ᢞ୚ᖜ䛜ᗈ䛔䜏䛯䛔䛷䛩䚹௒ᅇ䛿ప⏝㔞䛷䚸㻌 㻌 㻌 㻌 㻌 㻌 㻌 䝺䞁䝖䝀䞁䛷䛾㦵䜃䜙䜣ホ౯䛸䛺䛳䛶䛔䜎䛩䚹MRI 䛷䛾㦵䜃䜙䜣ホ౯䛷䛿䚸᭷ពᕪ䛜ฟ䛶䛔䜛䛸㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛔䛖⤖ᯝ䛷䛩䛜䚸ᬑ㏻䛾䝺䞁䝖䝀䞁䛷䛾㦵䜃䜙䜣䛻䛴䛔䛶䚸䛿䛳䛝䜚䛸グ㍕䛥䜜䛶䛔䛺䛔䛾䛷䚸㻌 㻌 㻌 㻌 㻌 㻌 㻌 MRI 䝺䝧䝹䛷䛺䛔䛸ຠᯝ䛿ฟ䛶䛣䛺䛔䛾䛛䜒䛧䜜䜎䛫䜣䚹䛯䛰䛭䛾⏝㔞䜒௒ᅇ䛾つᐃ⏝㔞䛾᪉㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛜 60mg 䛷㢖ᅇ䛸䛺䛳䛶䛚䜚䜎䛩䛾䛷䚸䛭䜜䛷䛒䜜䜀ຠᯝ䛜ᮇᚅ䛷䛝䜛䛾䛛䜒䛧䜜䜎䛫䜣䚹ᒣᮏጤဨ䠖䛔䜔䚸ᮏᙜ䛻ᢠయ䛜స⏝㒊఩䛻฿㐩䛩䜛䛾䛛䛸␲ၥ䜢ᣢ䛳䛯䛾䛷䚹୰ᒣ་ᖌ䠖㦵⢒㧼⑕䛾◊✲䛷䛿䚸⓶㉁㦵䛾㦵ᐦᗘ䛜༑ศ䛻ಖ䛯䜜䛶䛔䛟䛣䛸䛿ド᫂䛥䜜䛶䛚䜚䜎䛩䛾䛷䚸㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛭䛖䛔䛳䛯䛣䛸䜢⪃䛘䜛䛸䚸㛵⠇䝸䜴䝬䝏䛷ぢ䜙䜜䜛䜘䛖䛺㦵䜃䜙䜣䜢ᢚ䛘䜛ຠᯝ䜒ᮇᚅ䛷䛝䜛䛾㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛷䛿䛺䛛䛸⪃䛘䜎䛩䚹ᒣᮏጤဨ䠖䛭䜜䛷䛿䝍䞁䝟䜽䛾䝍䞊䞁䜸䞊䝞䞊䛿䚸䛹䛖⪃䛘䜎䛩䛛䚹6 䞃᭶䛻୍ᅇ䚹䜒䛴䛸ᛮ䛔䜎䛩䛛䚹୰ᒣ་ᖌ䠖6 䞃᭶䛻 1 ᅇ䛷䛩䛸䚸ᚰ䜒䛸䛺䛔䛸䛔䛖䛣䛸䛷䚸௒ᅇ䚸2 䛛᭶䚸3 䛛᭶䛻 1 ᅇ䛸䛧䛶䛔䜎䛩䚹䛣䜜䛿䛣㻌 㻌 㻌 㻌 㻌 㻌 㻌 䜜䜎䛷䛾㦵⢒㧼⑕䛾⮫ᗋ◊✲䛷䛿䚸⾜䜟䜜䛶䛔䛺䛛䛳䛯䛣䛸䛰䛸ᛮ䛔䜎䛩䚹䛭䛣䛷䚸䝸䜴䝬䝏䛾1㻌 㻌 㻌 㻌 㻌 㻌 㻌 㦵䜃䜙䜣䜢ᢚ䛘䜛䛻䛿䚸䛭䜜䛟䜙䛔䝍䞊䞁䜸䞊䝞䞊䜢⊃䜑䛺䛔䛸䛔䛡䛺䛔䛸䛔䛖䛣䛸䛷䛩䚹ᒣᮏጤဨ䠖䝍䞊䞁䜸䞊䝞䞊䜢䛳䛶䛔䛺䛔䛾䛷䛩䛛䚹୰ᒣ་ᖌ䠖䜾䝷䝣䛜䛤䛦䛔䜎䛧䛯䚹἞㦂⸆ᴫせ᭩䛾 45 䝨䞊䝆䚹䛣䜜䛿㦵⢒㧼⑕䜢ᑐ㇟䛻⾜䜟䜜䛯䝕䝜䝇䝬㻌 㻌 㻌 㻌 㻌 㻌 㻌 䝤 60mg䚸6 䜹᭶ẖ䛻ᢞ୚䛧䛯⾑୰⃰ᗘ䛾᥎⛣䛷䛤䛦䛔䜎䛩䛜䚸ᐇ⥺䛷᭩䛛䜜䛶䛚䜚䜎䛩䚹䜔䛿㻌 㻌 㻌 㻌 㻌 㻌 㻌 䜚 6 䞃᭶䛻䛺䜚䜎䛩䛸䝧䞊䝇䝷䜲䞁䛸ྠ⛬ᗘ䛻䛿ⴠ䛱䛶䛧䜎䛖䚹ᒣᮏጤဨ䠖䛭䜜䛷⾑୰⃰ᗘ䜢 䜛䛾䛷䛧䜗䛖䚹䛡䜜䛹䜒䚸ᐇ㝿䚸௒ᅇ䜒䚸䛱䜗䛳䛸䜒䛴䛾䛛䛸Ẽ䛻䛺䛳䛶䚸୰ᒣ་ᖌ䠖䛭䛖䛷䛩䛽䚹ᒣᮏጤဨ䠖ᢠయ䜢స䜛䛛䜒䛧䜜䛺䛔䛸䛔䛖䛣䛸䛿᭩䛔䛶䛒䜚䜎䛩䛜䚸䛭䜜䜘䜚䜒䜒䛴䛾䛛䛺䛸䚸ศゎ䛥䜜䛺䛔㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛾䛛䛺䛸䛔䛖䛣䛸䛷䛩䚹ᑠᔱጤဨ䠖⣲ே䛾㉁ၥ䛷⏦䛧ヂ䛺䛔䛷䛩䛜䚸䛣䛾๪స⏝䛻ప䜹䝹䝅䜴䝮⾑⑕䛺䛹䛜䛒䜚䚸䝡䝍䝭䞁䠠䜔䜹䝹㻌 㻌 㻌 㻌 㻌 㻌 㻌 䝅䜴䝮䜢᭹⏝䛥䛫䜎䛩䛜䚸௚䛾䜹䝹䝅䜴䝮௦ㅰ䛻㛵ಀ䛩䜛䝩䝹䝰䞁 PTH 䛸䛛䜹䝹䝅䝖䝙䞁䛻ᙳ㻌 㻌 㻌 㻌 㻌 㻌 㻌 㡪䛩䜛䛣䛸䛿䛒䜚䜎䛫䜣䛛䚹䛭䛧䛶䝡䝍䝭䞁䠠䛺䛹䜢ᦤ䜜䜀኱୔ኵ䛺䛾䛷䛩䛛䚹୰ᒣ་ᖌ䠖䛿䛳䛝䜚䛸䛧䛯䛚⟅䛿䛷䛝䛺䛔䛾䛷䛩䛜䚸ఱ䜙䛛䛾㛵䜟䜚䛿䛒䜛䛾䛷䛿䛺䛔䛛䛸ᛮ䛔䜎䛩䚹䛯䛰㻌 㻌 㻌 㻌 㻌 㻌 㻌 ⮫ᗋ⑕≧䜢㉳䛣䛧䛶䛧䜎䛖䜋䛹䛾䜒䛾䛿䚸ప䜹䝹䝅䜴䝮⾑⑕䛾㢖ᗘ䛜୍␒㧗䛟䛶䚸䛭䜜䛷ලྜ㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛾ᝏ䛟䛺䜛᪉䛿䛔䜙䛳䛧䜓䜛䛸䛔䛖䛣䛸䛷䛩䛜䚸௚䛾䝩䝹䝰䞁␗ᖖ䛻䜘䛳䛶⑕≧䜢㉳䛣䛧䛯䛸䛔䛖㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛣䛸䛿䚸ᑡ䛺䛟䛸䜒䛣䜜䜎䛷䛾㦵⢒㧼⑕䛾◊✲䚸⮫ᗋヨ㦂䛷䛿ゝ䜟䜜䛶䛔䛺䛔䛸ᛮ䛔䜎䛩䚹ᒣᮏጤဨ䠖◚㦵⣽⬊䛿 Specific 䛰䛛䜙䚸䝩䝹䝰䞁䛻䛿㛵ಀ䛧䛺䛔䛷䛩䚹◚㦵⣽⬊䛭䛾䜒䛾䛾 Specific 䛺ศ㻌 㻌 㻌 㻌 㻌 㻌 㻌 ໬䛭䛾䜒䛾䜢ᢚ䛘䛶䛧䜎䛖䛾䛷䛩䛛䜙୰ᒣ་ᖌ䠖䜹䝹䝅䜴䝮䛜㠀ᖖ䛻ప䛟䛺䛳䛶䛧䜎䛳䛯䛣䛸䛻䜘䛳䛶䚸ᒣᮏጤဨ䠖䛭䜜䛿䚸◚㦵⣽⬊䛜ᢚ䛘䜙䜜䛯䛛䜙䛷䛩䛽䚹୰ᒣ་ᖌ䠖☜䛛䛻䛭䛖䛷䛩䚹䛣䛾≀㉁䛿䚸RANKL 䛻ᑐ䛧䛶㠀ᖖ䛻≉␗ᛶ䛜㧗䛔䛸䛔䛖䛣䛸䛜≉ᚩ䛷䛤䛦䛔㻌 㻌 㻌 㻌 㻌 㻌 㻌 䜎䛩䛾䛷ᒣᮏඛ⏕䛜䛚䛳䛧䜓䜛䛸䛚䜚䛷䛤䛦䛔䜎䛩䚹ᑠᔱጤဨ䠖䛣䛾ྠពㄝ᫂᭩䛿㠀ᖖ䛻ศ䛛䜚䜔䛩䛟䛶䛸䛶䜒䛔䛔䛸ᛮ䛖䛾䛷䛩䛜䚸䠍䞄ᡤ䛰䛡἞㦂⸆䛾 5 䝨䞊㻌 㻌 㻌 㻌 㻌 㻌 㻌 䝆䛾䠝䠩䠣-162 䛻䛴䛔䛶䛾䛸䛣䜝䛷䚸䜴䝅⏤᮶ཎᩱ䛾䛸䛝䛻䛿䚸BSE 䛾༴㝤䛿䛒䜚䜎䛫䜣䛸䛔䛖㻌 㻌 㻌 㻌 㻌 㻌 㻌 䛣䛸䜢᭩䛟䛣䛸䛻䛺䛳䛶䛔䜛䛾䛷䛩䛛䚹ᒣᮏጤဨ䠖䛺䛳䛶䛔䜎䛩䚹ᑠᔱጤဨ䠖䛛䛘䛳䛶᭩䛔䛶䛒䜛䛸䚸ᝈ⪅䛻୙Ᏻ䜢୚䛘䜛䛣䛸䛻䛺䜚䜎䛫䜣䛛䚹ᒣᮏጤဨ䠖ゝ䜟䛺䛔䛸䛔䛡䛺䛔䚹౑䛘䛺䛔䚹ᑠᔱጤဨ䠖䜴䝅䛾ᮦᩱ䜢౑䛖᫬䛻䛿䚸グ㏙䛧䛺䛡䜜䜀䛔䛡䛺䛔䛾䛷䛩䛽䚹᭷㞴䛖䛤䛦䛔䜎䛩䚹ጤဨ㛗䠖㣬䛟䜎䛷䝸䜴䝬䝏䛻ᑐ䛧䛶䛿䚸඲䛟㛵ಀ䛺䛟䛶䚸㦵䛻㛵䛧䛶䛹䛖䛛䛸䛔䛖䛣䛸䛾䜏䛷䛩䛛䚹୰ᒣ་ᖌ䠖ᡤㅝ䚸௚䛾⏕≀Ꮫⓗ〇๣䛾䜘䛖䛻ᢠ⅖⑕స⏝䜢ᮇᚅ䛧䛶䚸䝸䜴䝬䝏䜢ᨵၿ䛥䛫䜛䛸䛔䛖⸆๣䛷㻌 㻌 㻌 㻌 㻌 㻌 䛿䛒䜚䜎䛫䜣䚹◚ቯ䜢ᢚ䛘䜛䛸䛔䛖䛾䛜୺┠ⓗ䛸䛺䜚䜎䛩䚹㻌 㻌 㻌 㻌 㻌 㻌 ᖾ䛔௒ᅇ䛿䝯䝖䝖䝺䜻䝃䞊䝖䜢ే⏝䛧䛺䛔䛣䛸䛻䛿䚸䝸䜴䝬䝏඲య䛜Ⰻ䛟䛺䜛䛛䛹䛖䛛ᚰ䜒䛸䛺䛔䛸㻌 㻌 㻌 㻌㻌 㻌 㻌 㻌 㻌 㻌 䛔䛖䛣䛸䜒䛒䜚䜎䛧䛶䚸ⓙ䛥䜣䛻ే⏝䛧䛶䛔䛯䛰䛟䛣䛸䛻䛺䜚䜎䛩䚹ᒣᮏጤဨ䠖 12 ౛䜶䞁䝖䝸䞊䛿䛒䜚䜎䛩䛛䚹୰ᒣ་ᖌ䠖䝯䝖䝖䝺䜻䝃䞊䝖䚸5 ᖺ௨ෆ䛸䛔䛖᪉䛜䛚䜚䜎䛩䛾䛷䚸ᒣᮏጤဨ䠖⏕≀〇๣౑䛳䛶䛔䜜䜀䝎䝯䛷䛩䛛䜙䛽䚹୰ᒣ་ᖌ䠖⏕≀〇๣䛿䛰䜑䛷䛩䚹䛷䛩䛛䜙䚸䛣䜜䜎䛷䛻⏕≀〇๣䜢౑䛖䜘䛖䛺䛛䛺䜚㐍⾜䛧䛶䛧䜎䛳䛯䝸䜴㻌 㻌 㻌 㻌 㻌 㻌 㻌 䝬䝏䛾᪉䛷䛿䛺䛟䛶䚸䝯䝖䝖䝺䜻䝃䞊䝖䜢ᶆ‽ⓗ䛻౑䛳䛶䛔䛶䚸䛹䛣䛛䛧䜙䛾㛵⠇䛻◚ቯ䛜䛒䛳㻌 㻌 㻌 㻌 㻌 㻌 䛶䚸䛭䛾㐍⾜䜢ᚰ㓄䛥䜜䛶䛔䜛䜘䛖䛺ᝈ⪅䛥䜣䛻䛿✚ᴟⓗ䛻䛚່䜑䛧䛶䛔䛣䛖䛸ᛮ䛳䛶䛚䜚䜎2䛩䚹␜㛫ጤဨ䠖⤖ᵓཝ䛧䛔䛸ᛮ䛔䜎䛩䚹஦๓䛾䝇䜽䝸䞊䝙䞁䜾䛜኱஦䛷䚸ᡃ䚻䛾䝕䞊䝍䝧䞊䝇䛷䜏䜛䛸䜶䞁䝖䝸㻌 㻌 㻌 㻌 㻌 㻌 䞊䛾䛚䜘䛭᭱⤊᪥䛒䛯䜚䛷䚸᫬㛫ⓗ䛺 5 ᖺᮍ‶䛰䛸 183 ே䛔䜎䛩䚹䛭䛾୰䛷άືᛶ䛜䛒䛳䛶䚸䛺㻌 㻌 㻌㻌 㻌 㻌 㻌 㻌 㻌 䛚ୟ䛴䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䜢౑䛳䛶䛔䛺䛔䛸䛩䜛䛸஦๓䛻䝢䞁䝫䜲䞁䝖䛷㑅䜣䛷䛚䛛䛺䛡䜜䜀䛺㻌 㻌 㻌 㻌 㻌 㻌 䜚䜎䛫䜣䚹㻌 㻌 㻌 㻌 㻌 㻌 䛸䛣䜝䛷䚸୺せホ౯㡯┠䛜 Sharp Score 䛷䛩䜘䛽䚹䛣䜜䛿౛䛘䜀ᗄ䛴䛠䜙䛔䜢᭷ព䛺䜒䛾䛸ᤊ䛘㻌 㻌㻌 㻌 㻌 㻌 㻌 㻌 䜛䛣䛸䛻䛺䛳䛶䛔䜛䛾䛷䛩䛛䚹㻌 㻌 㻌 㻌 㻌 㻌 Ⰽ䚻ᩥ㠃䛜䛒䛳䛶䚸䝁䞁䝖䝻䞊䝹䛸ẚ㍑䛧䛶䚸⏕≀Ꮫⓗ〇๣䛸༉ᩛ䛩䜛䛠䜙䛔䛾䌖sharp 䛷䠉1.5䚹㻌 㻌 㻌 㻌 㻌 㻌 䛰䛛䜙 80 ே䛸ேᩘ䜢ฟ䛩᰿ᣐ䛜䚸൅䛻䛿ศ䛛䜙䛺䛛䛳䛯䚹᭱ᑠ᭷ពኚ໬䛜䛔䛟䛴䛺䛾䛛䜢䛿䛳㻌 㻌 㻌 㻌 㻌 㻌 䛝䜚♧䛧䛶䜋䛧䛔䚹䛹䛣䛛䛻᭩䛔䛶䛒䛳䛯䛸ᛮ䛔䜎䛩䛜䚸䛭䛾ᑟ䛝䛰䛧᪉䛜䚸㐣ཤ䛾⏕≀Ꮫⓗ〇㻌 㻌 㻌 㻌 㻌 㻌 ๣䛸ྠ➼䛠䜙䛔䛻᭩䛔䛶䛒䛳䛯䛾䛷኱୔ኵ䛛䛺䛸䚸㻌 㻌 㻌 㻌 㻌 㻌 䛭䜜䛛䜙㦫䛔䛯䛾䛿䚸䝕䝜䝇䝬䝤䛿䚸䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䛾䜘䛖䛻䛭䜣䛺䛻䛔䛴䜎䛷䜒䜺䝏䜺䝏㻌㻌 㻌 㻌 㻌 㻌 㻌 䛻䛟䛳䛴䛔䛶䛔䜛䜒䛾䛷䛿䛺䛔䛸ᛮ䛳䛶䛔䛯䛾䛷䛩䛜䚸ᮏ㝔䛻䛿⤖ᵓ䛔䜎䛩䜘䛽䚸㢡㦵ቯṚ䛜䚸㻌 㻌 㻌 㻌 㻌 㻌 㟼ὀ䛾䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䛸ྠ➼䛠䜙䛔䛻䚸䛯䛰൅䛿ᜍ䜙䛟䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䛿୍ᗘᾘ䛘䜛䛸㻌 㻌 㻌 㻌 㻌 㻌 䜒䛖ᜍ䜙䛟䜋䜌ṧ䛳䛶䛧䜎䛖䛾䛷䚸㐣ཤ䛾୍᭚㟢䛷䜒ᑿ䜢ᘬ䛳ᙇ䛳䛶䛔䛟䛛䜒䛧䜜䛺䛔䛡䜜䛹䚸䝕䝜㻌 㻌 㻌 㻌 㻌 㻌 䝇䝬䝤䛿䚸䛭䜣䛺䛣䛸䛿䛺䛔䛾䛷䛿䛺䛔䛛䛸ᛮ䛳䛶䛔䛯䛾䛷䛩䚹䛭䜜䜢䛱䜗䛳䛸☜ㄆ䛧䛶ḧ䛧䛟䛶䚸㻌 㻌 㻌 㻌 㻌 㻌 せ䛩䜛䛻䛣䛾䝕䝜䝇䝬䝤䛸䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䜢ẚ㍑䛧䛯⒴䛾䜿䞊䝇䝁䞁䝖䝻䞊䝹䝇䝍䝕䜱䞊䛷䛿㻌 㻌 㻌 㻌 㻌 㻌 ྠ䛨ẚ䛻䛺䛳䛶䛿䛔䜛䛾䛰䛡䜜䛹䜒䚸ᜍ䜙䛟䝕䝜䝇䝬䝤䛿ᢞ୚୰䛻㉳䛝䛶䛔䜛ே䛰䛡䛨䜓䛺䛔䛛䛺㻌 㻌 㻌 㻌 㻌 㻌 䛸ᛮ䛖䛾䛷䛩䚹䛰䛛䜙䛭䛾ᮇ㛫 1 ᖺ㛫䛰䛡ぢ䜜䜀ྠ➼䛛䜒䛧䜜䛺䛔䛡䜜䛹䜒䚸౛䛘䜀䚸䛹䜣䛹䜣㻌 㻌 㻌 㻌 㻌 㻌 ⣼✚䛥䜜䛶䛔䛟䛸ᕪ䛜ฟ䛶䛟䛛䜒䛧䜜䛺䛔䛛䛺䛸䛔䛖Ẽ䛜䛧䜎䛩䚹ᒣᮏጤဨ䠖ᢞ୚ᮇ㛫䛿 1 ᖺ䛷䛧䜗䚹䛣䛾ሙྜ䚸䛭䜜䛷䛭䛖䛔䛖䛣䛸䛜㉳䜚䜎䛩䛛䚹␜㛫ጤဨ䠖㉳䛣䛳䛶䛔䜛䜏䛯䛔䛷䛩䚹ጤဨ㛗䠖௚䛾἞㦂䚹㦵㌿⛣䛾ே䛾἞㦂䛷䚸␜㛫ጤဨ䠖☜䛛䛻 120mg 䛸䛔䛖ಸ䛾㔞䛷䚸ẖ᭶䛰䛛䜙䚸䛣䜜䛾୍␒㧗⏝㔞䛾 4 ಸ䛠䜙䛔䛷䛩䛽䚹༢⣧䛻 4㻌 㻌 㻌 㻌 㻌 㻌 ศ䛾 1 䛸䛔䛳䛶䛔䛔䛾䛛ศ䛛䜙䛺䛔䛷䛩䛡䛹䚸䛭䜜䛷䜒 0.5%䛷䛩䛛䜙䚸⤖ᵓ䛛䛺䛸ᛮ䛳䛶䚹୰ᒣ་ᖌ䠖௮䜛䛸䛚䜚䛷䚸0.5%䛸䛔䛖䛸䚸䛭䜣䛺䛻㧗䛟䛺䛔ᵝ䛷䛩䛜䚸䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䛻䜘䜛㢡㦵ቯṚ㻌 㻌 㻌 㻌 㻌 㻌 䛜䚸䜒䛳䛸ప㢖ᗘ䚸⤒ཱྀ䛾ሙྜ䛻䛿䚸20 ୓ே䛻 1 ᱆⛬ᗘ䛾䜒䛾䛷䛩䛾䛷䚸䛭䜜䛻ẚ䜉䜜䜀☜䛛㻌 㻌 㻌 㻌 㻌 㻌 䛻䛣䜜䜎䛷䛾ሗ࿌䛷䛿䚸䛿䜛䛛䛻㢖ᗘ䛜㧗䛟䛺䜚䜎䛩䚹䛯䛰䚸ᝏᛶ⭘⒆䛾㦵㌿⛣䛻㛵䛧䛶䚸ᝏᛶ㻌 㻌 㻌 㻌 㻌 㻌 ⭘⒆䛜䛒䜛䛸䛔䛖䛣䛸䛷䚸䜒䛖䝸䝇䜽䜢ୖ䛢䜛䛣䛸䛜▱䜙䜜䛶䛚䜚䜎䛩䛧䚸ෆᐜ䜢ㄞ䜏䜎䛩䛸䜔䛿䜚㻌 㻌 㻌 㻌 㻌 㻌 ཱྀ⭍ෆ䛾౵くⓗ䛺἞⒪䜢䛧䛯᪉䛻᫂䜙䛛䛻㧗䛛䛳䛯䛸䛔䛖䛣䛸䜒䛒䜚䜎䛩䛾䛷䚸௒ᅇ䛭䛖䛔䛳䛯䛸㻌 㻌 㻌 㻌 㻌 㻌 䛣䜝䜢㝖እ䛧䛶䛚䜚䜎䛩䛛䜙䚸䛹䜜䛰䛡䛾㢖ᗘ䛻䛺䜛䛛䚹ᙜ↛䝸䜴䝬䝏䛾᪉䛷䚸䛭䜜䛰䛡䛷㢡㦵㻌 㻌 㻌 㻌 㻌 㻌 ቯṚ䛾㢖ᗘ䛜䚸䝡䝇䝣䜷䝇䝣䜷䝛䞊䝖䜢㣧䜣䛷䛔䜛䛸㧗䛔䛸䛔䛖䛣䛸䛿ᡃ䚻䛾▱ぢ䛛䜙䜒ᢎ▱䛧䛶㻌 㻌 㻌 㻌 㻌 㻌 䛚䜚䜎䛩䛾䛷䚸༑ศ䛭䛾䛒䛯䜚䛾㓄៖䜢䛧䛶䛔䛟䛴䜒䜚䛷䛿䛤䛦䛔䜎䛩䚹␜㛫ጤဨ䠖వィ䛺䛟䜙䛔ㄝ᫂䛧䛶䛚䛔䛯᪉䛜䛔䛔䜘䛖䛻ᛮ䛔䜎䛩䚹ཱྀ⭍ෆ䜢Ύ₩䛻䛩䜛䛣䛸䛜኱஦䛰䛸䛛䚹ጤဨ㛗䠖௚䛿ዴఱ䛷䛧䜗䛖䛛䚹᭱ᚋ䛻୍䛴䛰䛡䚹ඛ⏕䛿㦵⢒㧼⑕䛻ヲ䛧䛔䛾䛷䚸䛣䜜 MRI 䛾᳨ᰝධ䜜䛶䛚㻌 㻌 㻌 㻌 㻌 㻌 䜚䜎䛫䜣䛽䚹୰ᒣ་ᖌ䠖MRI 䛿䚸䛿䛔䚹ጤဨ㛗䠖䛣䜜䛿䚸᪋タ䛻䜘䛳䛶↓䛔䛣䛸䜒䛒䜛䛛䜙䛷䛧䜗䛖䛡䜜䛹䜒䚸ඛ⏕䛿䚸䝺䞁䝖䝀䞁䛸㦵ᐦᗘ䛾㦵䝬䞊㻌 㻌 㻌 㻌 㻌 䜹䞊䛷䚸1 ᖺ㛫䛾ኚ໬䜢ẚ㍑䛷䛝䜛䛸䛚⪃䛘䛷䛩䛛䚹ᮏᙜ䛿 MRI 䜢ධ䜜䛯᪉䛜䛔䛔䛸୰ᒣ་ᖌ䠖㦵ᐦᗘ䚸䛭䜜䛿㦵䜃䜙䜣䛾䛣䛸䛷䛩䛽䚹㦵䜃䜙䜣䜢デ䜛䛻㛵䛧䛶䛿䚸☜䛛䛻䚸䛣䜜䜎䛷䛾䝯䞊䜹3㻌 㻌 㻌 㻌 㻌 㻌 䞊䛷⾜䜟䜜䛯἞㦂䛷䛿䚸MRI 䛷䛾䜃䜙䜣䝇䝁䜰䛜ῶ䛳䛶䛔䜎䛩䚹䛴䜎䜚᭷ពᕪ䛜ฟ䛯䛸䛔䛖䛣䛸䛷㻌 㻌 㻌 㻌 㻌 㻌 䛩䚹䝺䞁䝖䝀䞁䛷䛔䛛䛜䛺䜒䛾䛛䛿䚸䜔䛳䛶䜏䛺䛔䛸ศ䛛䜚䜎䛫䜣䚹ᒣᮏጤဨ䠖MRI 䛿᧜䜙䛺䛔䛸䛔䛖䛣䛸䛷䛩䛽䚹ጤဨ㛗䠖௒ᅇ䛿᧜䜙䛺䛛䛳䛯䛷䛩䛽䚹୰ᒣ་ᖌ䠖௒ᅇ䛿ධ䛳䛶䛔䛺䛔䛷䛩䚹ᒣᮏጤဨ䠖᧜䛳䛯᪉䛜䛔䛔䛛䜒䛧䜜䛺䛔䛷䛩䛽䚹ᝈ⪅䛥䜣䛾䛯䜑䛻䜒䚹୰ᒣ་ᖌ䠖஺΅䛿䛧䛶䜏䜎䛩䚹ጤဨ㛗䠖䜘䜝䛧䛡䜜䜀䚸⤊䜟䜚䜎䛩䚹䛹䛖䜒䛒䜚䛜䛸䛖䛤䛦䛔䜎䛧䛯䚹୰ᒣ་ᖌ䠖ᐅ䛧䛟䛚㢪䛔⮴䛧䜎䛩䚹䛒䜚䛜䛸䛖䛤䛦䛔䜎䛧䛯䚹㻌ᑂ㆟⤖ᯝ㻌 䠖ᢎ㻌 ㄆ㻌㻌㻌 㻔㻞㻕㻌

⏣㎶୕⳻〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛⊩⾑䞂䜵䝜䜾䝻䝤䝸䞁 IH䠄ᕝᓮ⑓ᅇ᚟ᮇཬ䜃ᑠඣ ITP 䛻䛚䛡䜛Ⓨ
⑈Ⓨ⌧≧ἣㄪᰝ䠅䛾౑⏝ᡂ⦼ㄪᰝ䛆ᑂ㆟஦㡯䛇㻌౑⏝ᐇែୗ䛻䛚䛡䜛ㄪᰝᐇ᪋䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻔㻟㻕㻌 ኱ṇᐩᒣ་⸆ရᰴᘧ఍♫䛾౫㢗䛻䜘䜛䝌䝅䞁㟼ὀ⏝ 2.25䚸4.5 䛾౑⏝ᡂ⦼ㄪᰝ䛆ᑂ㆟஦㡯䛇㻌౑⏝ᐇែୗ䛻䛚䛡䜛ㄪᰝᐇ᪋䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻔㻠㻕㻌୰እ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛䝨䜺䝅䝇®⓶ୗὀ/䝁䝨䜺䝇®㘄䛾≉ᐃ౑⏝ᡂ⦼ㄪᰝ䠄C ᆺ៏ᛶ⫢⅖᪤἞⒪౛䛻ᑐ䛩䜛ᮏే⏝⒪ἲ䛾ㄪᰝ䠅䛆ᑂ㆟஦㡯䛇㻌෌ᑂᰝไᗘ䛻ᇶ䛵䛟ㄪᰝ䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌䠎㻌 㻌 Ᏻ඲ᛶ᝟ሗ➼ሗ࿌ཬ䜃἞㦂䛻㛵䛩䜛ኚ᭦ሗ࿌㻌 㻌㻌㻔㻝㻕㻌➨୍୕ඹᰴᘧ఍♫䛾౫㢗䛻䜘䜛䜰䝹䝒䝝䜲䝬䞊ᆺ⑵࿈䜢ᑐ㇟䛸䛧䛯 㻿㼁㻺㻌 㼅㻣㻜㻝㻣䠄䝯䝬䞁䝏䞁ሷ㓟ሷ䠅䛾㛗ᮇᢞ୚ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌4㻔㻞㻕㻌䝤䝸䝇䝖䝹䞉䝬䜲䝲䞊䝈ᰴᘧ఍♫䛾౫㢗䛻䜘䜛㛵⠇䝸䜴䝬䝏䜢ᑐ㇟䛸䛧䛯 㼍㼎㼍㼠㼍㼏㼑㼜㼠䠄㻮㻹㻿㻙㻝㻤㻤㻢㻢㻣䠅䛾㛗ᮇ䠄⥅⥆䠅ᢞ୚ヨ㦂㻔➨䊢┦⮫ᗋヨ㦂㻕㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌㻌㻌㻌㻔㻟㻕㻌䝤䝸䝇䝖䝹䞉䝬䜲䝲䞊䝈ᰴᘧ఍♫䛾౫㢗䛻䜘䜛㛵⠇䝸䜴䝬䝏䜢ᑐ㇟䛸䛧䛯 㼍㼎㼍㼠㼍㼏㼑㼜㼠 䛾➨䊡┦㻛䊢┦⮫ᗋヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ㄝ᫂ྠពᩥ᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌㉁ 㻌 ␲ 㻌 ᛂ 㻌 ⟅㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻠㻕㻌 䜶䞊䝄䜲ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻱㻜㻟㻜㻞 䛾ᚋᮇ➨䊡┦㻛➨䊢┦⮫ᗋヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㝔ෆ䛷Ⓨ⌧䛧䛯㔜⠜䛺᭷ᐖ஦㇟䛻ᇶ䛵䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌౫㢗⪅ഃ἞㦂ᐇ᪋యไ䚸἞㦂ᐇ᪋᪋タデ⒪⛉ྡ䚸㈐௵་ᖌ䚸⫋ྡ䛾ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾ほⅬ䛛䜙ᑂ㆟䛧䛯䚹㻌἞㦂⸆ᴫせ᭩䛾ᨵゞ䛻ᇶ䛵䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 㻌 ㄆ㻌㻌㻌㻔㻡㻕㻌 䜶䞊䝄䜲ᰴᘧ఍♫䛾౫㢗䛻䜘䜛➽ⴎ⦰ᛶഃ⣴◳໬⑕䛻ᑐ䛩䜛 㻱㻜㻟㻜㻞 䛾⮫ᗋヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌౫㢗⪅ഃ἞㦂ᐇ᪋యไ䚸἞㦂ᐇ᪋᪋タデ⒪⛉ྡ䚸㈐௵་ᖌ䛾ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾ほⅬ䛛䜙ᑂ㆟䛧䛯䚹㻌἞㦂⸆ᴫせ᭩䛾ᨵゞ䛻ᇶ䛵䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 㻌 ㄆ㻌㻌㻌䠄㻢䠅㻌኱ሯ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻿㻼㻹㻌 㻥㻢㻞 䛾䝟䞊䜻䞁䝋䞁⑓䜢ᑐ㇟䛸䛧䛯➨䊡┦㻛➨䊢┦䚸⥅⥆㛗ᮇヨ㻌㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 䛆ሗ࿌஦㡯䛇㻌5἞㦂⤊஢ሗ࿌㻌㻌㻌㻌 㻔㻣㻕㻌 ኱ሯ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻿㻼㻹㻌 㻥㻢㻞 䛾䝟䞊䜻䞁䝋䞁⑓䜢ᑐ㇟䛸䛧䛯➨䊢┦ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂ᐇ᪋ィ⏬᭩㻔㈨ᩱ㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 㻌 ㄆ㻌㻌㻌㻌 㻔㻤㻕㻌 ኱ሯ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻿㻼㻹㻌 㻥㻢㻞 䛾䝟䞊䜻䞁䝋䞁⑓䜢ᑐ㇟䛸䛧䛯➨䊢┦ヨ㦂䚸⥅⥆㛗ᮇヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂ᐇ᪋ィ⏬᭩㻔㈨ᩱ㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 㻌 ㄆ㻌㻌㻌㻔㻥㻕㻌 ኱ṇ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻾㼛㻞㻜㻜㻙㻡㻠㻡㻜㼕㼢 䛻䜘䜛➨䊡┦㻛➨䊢┦⮫ᗋヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂ᐇ᪋ィ⏬᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ㄝ᫂ྠពᩥ᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 ⤖㻌 㻌 㻌ᯝ㻌㻌 㻌 䠖㻌㻌 㻌ᢎ㻌㻌 ㄆ㻌㻌㻌㻔㻝㻜㻕㻌 䝣䜯䜲䝄䞊ᰴᘧ఍♫䛾౫㢗䛻䜘䜛㛵⠇䝸䜴䝬䝏䜢ᑐ㇟䛸䛧䛯 㻯㻼㻙㻢㻥㻜㻘㻡㻡㻜 䛾➨䊢┦ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᾏእ䛷ᐇ᪋୰䛾㛵⠇䝸䜴䝬䝏䜢ᑐ㇟䛸䛧䛯⮫ᗋヨ㦂(A3921046)䛷ㄆ䜑䜙䜜䛯㔜⠜䛺ឤᰁ⑕䛾ヨ㦂⥅⥆䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆ᴫせ᭩䛾ᨵゞ䛻ᇶ䛵䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 ⤖㻌 㻌 㻌ᯝ㻌㻌 㻌 䠖㻌㻌 㻌ᢎ㻌㻌 ㄆ㻌㻌㻌
㻔㻝㻝㻕㻌 䝣䜯䜲䝄䞊ᰴᘧ఍♫䛾౫㢗䛻䜘䜛➨䊡┦ヨ㦂㻌㻌 㻌 䛆ሗ࿌஦㡯䛇㻌἞㦂⤊஢ሗ࿌㻌6㻔㻝㻞㻕㻌 ⴙ᭷〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛῝ᅾᛶ┿⳦⑕ᝈ⪅䜢ᑐ㇟䛸䛧䛯 㻹㻷㻙㻜㻥㻥㻝 䛾➨䊢┦ヨ㦂䛆䡭䢖䢕䡳䢚䡬⛉䛇㻌䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ἞㦂⸆䛻㛵ಀ䛩䜛ᥐ⨨䞉◊✲ሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂ศᢸ་ᖌ䚸἞㦂ዎ⣙᭩䚸἞㦂ᐇ᪋యไ䛾ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾ほⅬ䛛䜙ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋་⒪ᶵ㛵ཬ䜃἞㦂㈐௵་ᖌ䛾ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾ほⅬ䛛䜙ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 ᯝ㻌㻌 㻌 㻌䠖㻌㻌 ᢎ㻌㻌 㻌 ㄆ㻌
㻌㻌㻌㻌㻔㻝㻟㻕㻌 ⴙ᭷〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛῝ᅾᛶ┿⳦⑕ᝈ⪅䜢ᑐ㇟䛸䛧䛯 㻹㻷㻙㻜㻥㻥㻝 䛾➨䊢┦ヨ㦂䛆䝸䜴䝬䝏⛉䛇㻌䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ἞㦂⸆䛻㛵ಀ䛩䜛ᥐ⨨䞉◊✲ሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋యไ䚸἞㦂ᐇ᪋་⒪ᶵ㛵ཬ䜃἞㦂㈐௵་ᖌ䛾ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾ほⅬ䛛䜙ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻝㻠㻕㻌 ⏣㎶୕⳻〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛ᚋᮇ➨䊡┦㻛➨䊢┦⮫ᗋヨ㦂䠄ే⏝ヨ㦂䠅㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆䛻㛵ಀ䛩䜛ᥐ⨨ሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩㻔㈨ᩱ㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ㄝ᫂ྠពᩥ᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 ἞㦂ཧຍ䜹䞊䝗䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻌㻔㻝㻡㻕㻌 ⏣㎶୕⳻〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛ᚋᮇ➨䊡┦㻛➨䊢┦⮫ᗋヨ㦂䠄༢๣ᢞ୚䠅㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆䛻㛵ಀ䛩䜛ᥐ⨨ሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩㻔㈨ᩱ㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ㄝ᫂ྠពᩥ᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 ἞㦂ཧຍ䜹䞊䝗䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌
㻌7㻔㻝㻢㻕㻌 䜶䞊䝄䜲ᰴᘧ఍♫䛾౫㢗䛻䜘䜛᪥ᮏே㛵⠇䝸䜴䝬䝏ᝈ⪅䜢ᑐ㇟䛸䛧䛯䜰䝎䝸䝮䝬䝤㻔㻰㻞㻱㻣㻕䛾➨䊢┦ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 㻌 ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 㝔ෆ䛷Ⓨ⌧䛧䛯㔜⠜䛺᭷ᐖ஦㇟䛻ᇶ䛵䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩㻔ᮏᩥ䚸ู⣬㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧㻌㻌 㻌 㻌 䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻌㻔㻝㻣㻕㻌 ༠࿴Ⓨ㓝䜻䝸䞁ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻷㼃㻙㻢㻜㻜㻞 䛾䝟䞊䜻䞁䝋䞁⑓䜢ᑐ㇟䛸䛧䛯➨䊢┦ヨ㦂㻌ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂ཧຍ䜹䞊䝗䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻔㻝㻤㻕㻌 ༠࿴Ⓨ㓝䜻䝸䞁ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻷㼃㻙㻢㻜㻜㻞 䛾䝟䞊䜻䞁䝋䞁⑓䜢ᑐ㇟䛸䛧䛯➨䊢┦㛗ᮇᢞ୚ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻝㻥㻕㻌༠࿴Ⓨ㓝䜻䝸䞁ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 KW䠉6500 ➨䊢┦⮫ᗋヨ㦂䠄䝟䞊䜻䞁䝋䞁⑓ᝈ⪅䜢ᑐ㇟䛸䛧䛯㛗ᮇ䛾ᅾᏯ⮬ᕫὀᑕ䛻䛚䛡䜛Ᏻ඲ᛶヨ㦂䠅(PRT No.6500-003)

䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌༠࿴Ⓨ㓝䜻䝸䞁ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 KW䠉6500 ➨䊢┦⮫ᗋヨ㦂㻔㻞㻜㻕㻌 䠄䝟䞊䜻䞁䝋䞁⑓ᝈ⪅䜢ᑐ㇟䛸䛧䛯䝥䝷䝉䝪ᑐ↷஧㔜┣᳨䜽䝻䝇䜸䞊䝞䞊ẚ㍑ヨ㦂䠅
(PRT No.6500-004)䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂ཧຍ䜹䞊䝗䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌8༠࿴Ⓨ㓝䜻䝸䞁ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 KW䠉6500 ➨䊢┦⮫ᗋヨ㦂㻔㻞㻝㻕㻌 䠄䝟䞊䜻䞁䝋䞁⑓ᝈ⪅䜢ᑐ㇟䛸䛧䛯ᅾᏯ⮬ᕫὀᑕ䛻䛚䛡䜛⥅⥆㛗ᮇᏳ඲ᛶヨ㦂䠅
(PRT No.6500-005)䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻞㻞㻕㻌 ᪥ᮏ䜲䞊䝷䜲䝸䝸䞊ᰴᘧ఍♫䛾౫㢗䛻䜘䜛➨䊠┦⮫ᗋヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌 㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻌㻔㻞㻟㻕㻌 ᪥ᮏ䜲䞊䝷䜲䝸䝸䞊ᰴᘧ఍♫䛾౫㢗䛻䜘䜛➨䊠┦⮫ᗋヨ㦂䠄⥅⥆ᢞ୚ヨ㦂䠅㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩㻔ู෉㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻌㻔㻞㻠㻕㻌 ኱ሯ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛ᚋᮇ➨䊡┦㻛➨䊢┦⮫ᗋヨ㦂㻌䛆ሗ࿌஦㡯䛇㻌㻌 㻌 㻌 㻌 ἞㦂⤊஢ሗ࿌㻌㻌㻌㻔㻞㻡㻕㻌኱ሯ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛άືᛶ㛵⠇䝸䜴䝬䝏䜢ᑐ㇟䛸䛧䛯 㻯㻰㻼㻤㻣㻜 䛾 㻹㼀㼄 ే⏝᫬䛾㛗ᮇ⥅⥆ᢞ㻌୚ヨ㦂㻌㻌 㻌 䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋᪋タ䛷䛾἞㦂㈐௵་ᖌ⫋ྡ䚸㒑౽␒ྕ䚸᪂つᣦྡ䛻䜘䜛ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾ほⅬ䛛䜙㻌 㻌 㻌㻌 㻌 㻌 㻌 ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌 ㄆ㻌㻌㻌9㻔㻞㻢㻕㻌 䝜䝞䝹䝔䜱䝇㻌 䝣䜯䞊䝬ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻭㻵㻺㻠㻡㻣 䛾ᚋᮇ➨䊡┦ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻌㻔㻞㻣㻕㻌

኱᪥ᮏఫ཭〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛AD䠉810N 䛾䝟䞊䜻䞁䝋䞁⑓䜢ᑐ㇟䛸䛧䛯஧㔜┣᳨⩌㛫ẚ㍑䛻
䜘䜛᳨ドⓗヨ㦂[➨䊢┦ヨ㦂]䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 㻌 ㎿㏿ᑂᰝ䛻䛴䛔䛶ሗ࿌䛥䜜䛯䚹ྠពㄝ᫂ᩥ᭩䛾ಟṇ䛸䝣䜯䞊䝬䝁䝀䝜䝭䜽䝇᳨ウ䛾㒊ศ䜢㝖䛝䚸἞㦂䜢㛤㻌 㻌 㻌 ጞ䛻䛴䛔䛶䠄㻞㻜㻝㻜 ᖺ 㻤 ᭶ 㻞 ᪥ᐇ᪋䠖ᢎㄆ䠅㻌㻌 㻌 㻌 ἞㦂౫㢗⪅䛾㒔ྜ䛻䜘䜛䝰䝙䝍䝸䞁䜾ᢸᙜ⪅ኚ᭦䚸἞㦂ᐇ᪋᪋タ㏣ຍ䛻క䛖ኚ᭦䛻䛴䛔䛶䚸㐺᱁ᛶ䛾㻌㻌 㻌 㻌 ほⅬ䛛䜙ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ㄝ᫂ྠពᩥ᭩䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌㻌㻌
㻔㻞㻤㻕㻌 䝜䝞䝹䝔䜱䝇䝣䜯䞊䝬ᰴᘧ఍♫䛾౫㢗䛻䜘䜛䜸䝬䝸䝈䝬䝤䛾ᑠඣẼ⟶ᨭႍᜥ䛻ᑐ䛩䜛➨䊢┦⮫ᗋヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌ᾏእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩㻔ู⣬㻕䛾ᨵゞ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻞㻥㻕㻌 ୰እ〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛 㻹㻾㻭䠉㻿㻯 䛾㛵⠇䝸䜴䝬䝏ᝈ⪅䜢ᑐ㇟䛸䛧䛯➨䊢┦ẚ㍑ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ᅜෆእᏳ඲ᛶ᝟ሗ䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂⸆㔜⠜๪స⏝ᐃᮇሗ࿌䛻ᇶ䛵䛝ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌 㻌 ἞㦂ᐇ᪋ィ⏬᭩ཬ䜃⑕౛ሗ࿌᭩䛾ᨵゞ䛻䛴䛔䛶䚸ᘬ䛝⥆䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㻌㻌 㻌 㻌 ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻟㻜㻕㻌 ⛉◊〇⸆ᰴᘧ఍♫䛾౫㢗䛻䜘䜛䝧䝷䝃䝇 LA 㘄 60ȝ g㻌 ≉ᐃ౑⏝ᡂ⦼ㄪᰝ䛆ᑂ㆟஦㡯䛇㻌㻌 㻌 㻌 ㄪᰝዎ⣙ኚ᭦䛻䛴䛔䛶ᘬ䛝⥆䛝ㄪᰝ䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌㻌 㻌ᑂ㻌 㻌 㻌㆟㻌 㻌 㻌⤖㻌 㻌 㻌ᯝ㻌㻌 㻌䠖㻌㻌 ᢎ㻌㻌 ㄆ㻌
10㻔㻟㻝㻕㻌 䜶䝣䝢䞊ᰴᘧ఍♫䛾౫㢗䛻䜘䜛䝟䞊䜻䞁䝋䞁⑓ᝈ⪅䜢ᑐ㇟䛸䛧䛯 㻲㻼㻲㻝㻝㻜㻜㻺㼃 䛾➨䊡┦ヨ㦂㻌䛆ᑂ㆟஦㡯䛇㻌㝔ෆ䛷Ⓨ⌧䛧䛯㔜⠜䛺᭷ᐖ஦㇟䛻ᇶ䛵䛝἞㦂䜢ᐇ᪋䛩䜛䛣䛸䛾ጇᙜᛶ䛻䛴䛔䛶ᑂ㆟䛧䛯䚹㻌ᑂ ㆟ ⤖ ᯝ㻌 䠖㻌 ᢎ㻌 ㄆ㻌㻌㻌㻔㻟㻞㻕㻌᪥ᮏ䝧䞊䝸䞁䜺䞊䜲䞁䝀䝹䝝䜲䝮ᰴᘧ఍♫䛾౫㢗䛻䜘䜛䝥䝷䝭䝨䜻䝋䞊䝹 ER䠄ᚎᨺ䠅㘄䛾᪩ᮇ䝟䞊䜻䞁䝋䞁⑓ᝈ⪅䜢ᑐ㇟䛸䛯Ᏻ඲ᛶ䜢☜ㄆ䛩䜛㠀┣᳨㛗ᮇᢞ୚ヨ㦂㻌 㻌 䛆ሗ࿌஦㡯䛇㻌㻌 㻌 㻌 㻌 ἞㦂⤊஢ሗ࿌㻌㻌㻌㻔㻟㻟㻕㻌Ṋ⏣⸆ရᕤᴗᰴᘧ఍♫䛾౫㢗䛻䜘䜛 AG-1749 䛾㠀䝇䝔䝻䜲䝗ᛶᢠ⅖⑕⸆㛗ᮇᢞ୚᫬䛻䜏䜙䜜䜛⫶₽⒆䞉༑஧ᣦ⭠₽⒆䛾Ⓨ⑕䛻ᑐ䛩䜛ண㜵ຠᯝ䛾᳨ド㻌 㻌 䛆ሗ࿌஦㡯䛇㻌㻌 㻌 㻌 㻌 ἞㦂⤊஢ሗ࿌㻌㻌㻌㻌㻌11