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Inflammatory common diseases revealed by in vivo molecularimaging of microcirculation
Satoshi NISHIMURA*,**,***, Mika NAGASAKI*ŚóöÊöǌƲƿƸğƘà ŚȡŅÉŖȠ 
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Department of Cardiovascular Medicine,**Translational Systems Biology and Medicine Initiative,
The University of Tokyo, Tokyo, Japan***PRESTO, Japan Science and Technology Agency, Tokyo, Japan[Received: June 14, 2010]
Metabolic syndrome is a major risk factor of cardiovascular events, and adipose tissue obesity based on chronic
inflammation play a central role. To assess dynamic interplay between multiple cell-types in inflammatory diseases, invivo imaging technique based on single- and multi-photon microscopy was developed. Imaging revealed close spatial
and temporal interrelationships between angiogenesis and adipogenesis in obese adipose. In addition, increased
leukocyte-platelet-endothelial cell interactions in the microcirculation of obese adipose were observed, a hallmark of
inflammation. We also found that large numbers of CD8+ effector T cells infiltrated into obese adipose. Infiltration by
CD8+ T cells is essential for the initiation and development of adipose inflammation.
By our in vivo imaging technique, multiple cell types are specifically visualized, and thrombus formation was
induced by laser irradiation which cause ROS production inside the blood vessel. Using this technique, we revealed
Lnk/Sh2b3 regulates integrin alpha-IIb-beta-3 outside-in signaling in platelets leading to stabilization of developing
thrombus in vivo. In addition, we established human iPS-derived platelets, and tracked them in mice to elucidate its
function in vivo. We confirmed injected platelets circulate, and contributed to the thrombus formation in vivo, indicating
the clinical usefulness of this strategy for future.
Our results clearly demonstrated the power of our imaging technique to analyze complex cellular interplays ininflammatory diseases, especially parenchymal and stromal cell cross talks, and to evaluate new therapeuticinterventions against them.
Key Words: in vivo imaging, metabolic syndrome, adipose tissue, thrombus, platelet\[K
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Figure 2 Cell kinetic revealed by in vivo molecular imaging inliving animals
Cells are specifically labeled; erythrocyte, leukocyte, platelets,and endothelial cells. (a-c) one shot, (d) sequential
pseudo-colored image.
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Figure 1 Obese adipose tissue remodeling examined by in vivo
imaging
Lean (a-c), and obese (d,e) adipose tissue were visualized bynovel in vivo imaging method (b-e). Obese adipose tissue
remodeling including angiogenesis (arrows) and adipogenesis
are elucidated.

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Figure 4 Thrombus formation in vivo by in vivo imaging andlaser-induced-injury
Thrombus formation was induced by ROS production inducedby laser-induced-injuries. Mesenteric capillaries were visualized
by in vivo imaging technique.

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6 B
1. Nishimura S, et al, Adipogenesis in obesity requires close Į53hvMēX´ƋƊɈ°ôÅȍ4Ǒ

interplay between differentiating adipocytes, stromal cells<ÖG'/Ɲ­ÒĝHǳ,.)ɉ##ɈſȟǪàand blood vessels. Adipogenesis in obesity requires closeǪàµȟ4ŨȔ3ȯ#.5ÓǹÈ/&ɈȝôŬǢ?

interplay between differentiating adipocytes, stromal cells

ō/,)ɉƙ4ÕƼƢī/4Ǐǡȕȯĩê

and blood vessels. Diabetes, 2007; 56: 1517-1526.

țƟĊHACōB3%D)>35ɈĖī0ŬǢ0Ǒ<

2. Nishimura S, et al, In vivo imaging in mice reveals local cellÖG')ſȟ4°LzZ UěģǸ32D0ǜdynamics and inflammation in obese adipose tissue. J Clin

BEDɉ¢6ɈȝôŁðÇƑHƛ)ȝôŬǢ4

Invest 2008; 118: 710-721.

°3ADǻŜHɈ°ôoNyeƹX0Ƀȓ[S3. Nishimura S, et al, CD8+ effector T cells contribute to|h U´ƋƊY[cy/ǳ0?4/CɆFig.

macrophage recruitment and adipose tissue inflammation in5ɇɈě4°öŬà4ȭƧŁǭŒ;EDɉ

obesity. Nature Medicine 2009; 15: 914-920.
4. Nishimura S*, Takizawa H*, et al (*equal contribution),
Lnk/Sh2b3 regulates integrin alpha-IIb-beta-3 outside-in
signaling in platelets leading to stabilization of developing
thrombus in vivo. J Clin Invest, 2010; 120: 179-190.

Figure 5 Rapid and high-resolution multi-photon in vivo
imaging
Three dimensional (a) and live (b) images of adipose tissue werevisualized by novel multi-photon in vivo imaging systems.

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᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ㸦㟁Ꮚ∧㸧 ➨  ᕳ ➨  ྕ ࢆᨵၿࡍࡿࡔࡅ࡛࡞ࡃ㸪ࢱࣥࣃࢡ㉁ศゎ㓝⣲ࡢࢺࣜࣉᗘ࡜࡞ࡾ㸪㠀ᖖ࡟␯Ỉᛶࡢ㧗࠸⾲㠃࡜࡞ࡿ㸬⾑ᑠࢩࣥࡸࣇ࣮ࣟࢳࣕࣥࣂ࣮ࢆ⏝࠸ࡓホ౯࠿ࡽ㸪ࡑࡢ᥋╔ᯈ⢓╔ࡣ㸪ࢩ࣮ࢺᙧ≧࠿ࡽࢼࣀࣇ࢓࢖ࣂ࣮࡟ࡍࡿ

ᙉᗘࡶᨵၿࡉࢀࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠸ࡿ㸬ࡇ࡜࡛㸪࠿࡞ࡾᨵၿࡉࢀࡿࡓࡵ㸪ᮦᩱࡢ⾲㠃ᙧ≧ ࡲࡓ㸪ᮏ◊✲࡛ࡣ㸪࢚ࣞࢡࢺࣟࢫࣆࢽࣥࢢἲࢆ⏝ࡀ኱ࡁࡃᙳ㡪ࡋ࡚࠸ࡿࡶࡢ࡜⪃࠼ࡽࢀࡿ㸬࠸࡚ࢼࣀࣇ࢓࢖ࣂ࣮࠿ࡽ࡞ࡿ୙⧊ᕸ࡜ࡍࡿࡇ࡜࡛㸪 ࢚ࣞࢡࢺࣟࢫࣆࢽࣥࢢἲࡣ㸪ࢼࣀࣇ࢓࢖ࣂ࣮ࡢᇶᮦ࡟ᰂ㌾ᛶࢆᣢࡓࡏࡿ࡜࡜ࡶ࡟㸪⣽⬊᥋╔ᛶࢆࢥࣞࢡࢱ 㞟✚ᯈ ࢆᵝࠎ࡟ኚ࠼ࡿࡇ࡜ࡀ࡛ࡁࡿࡓ

ㄏᑟࡍࡿ⾲㠃ࢆᙧᡂࡋࡓ㸬࢚ࣞࢡࢺࣟࢫࣆࢽࣥࢢ

ࡵ㸪ࢳ࣮ࣗࣈ≧࡟ࡋࡓࡾ㸪ࢫࢸࣥࢺ࡬ࡢࢥ࣮ࢸ࢕

ἲࡣ㸪㧗㟁ᅽୗ࡛㸪⁐፹࡟⁐࠿ࡋࡓ㧗ศᏊ⁐ᾮࢆࣥࢢ࡞࡝㸪⮬⏤࡞ࢹࢨ࢖ࣥࡀྍ⬟࡛࠶ࡿ㸬࢖࢜ࣥࣀࢬࣝ࠿ࡽᢲࡋฟࡍࡇ࡜࡛㸪┤ᚄᩘࢼࣀ㹼ᩘ࣐࢖ࣅ࣮࣒↷ᑕࢆ⾜ࡗࡓࡇࡢᇶᮦࡣ㸪ඃࢀࡓ⣽⬊᥋╔ࢡ࣓࣮ࣟࢺࣝᚄࡢ⣽࠸ࣇ࢓࢖ࣂ࣮ࢆస〇ࡍࡿᢏ⾡ᛶࢆ᭷ࡍࡿࡓࡵ㸪⏕యᇙධᚋ࡟㎿㏿࡟⮬ᕫ⤌⧊ࡀ࡛࠶ࡿ㸬࢚ࣞࢡࢺࣟࢫࣆࢽࣥࢢἲ࡟ࡼࡗ࡚స〇ࡉᙧᡂࡉࢀ㸪⾑ᰦᙧᡂࢆᢚไࡍࡿࡇ࡜ࡀᮇᚅࡉࢀࡿ㸬ࢀࡓࢼࣀࣇ࢓࢖ࣂ࣮ࡣ㸪⣽⬊እ࣐ࢺࣜࢵࢡࢫ (&0ࡲࡓ㸪ேᕤ⾑⟶ࡢ㛤Ꮡᡂ⦼ࢆྥୖࡉࡏࡿࡓࡵ࡟㸪ࡢࣇ࢕ࣈࣜࣝᵓ㐀࡜㢮ఝࡋࡓᵓ㐀ࢆᣢࡕ㸪⾲㠃⏕య྾཰ᛶ㧗ศᏊࡢேᕤ⾑⟶࡬⾑⟶࠿ࡽ᥇ྲྀࡋࡓ

య✚ࡢ๭ྜࡀ㧗ࡃ㸪⣽⬊ቑṪࡸศ໬ࢆㄏᑟࡍࡿ࡜

ෆ⓶⣽⬊ࢆ࠶ࡽ࠿ࡌࡵᇵ㣴ࡋࡓᚋ࡟⛣᳜ࡍࡿࡇ࡜

ࡉࢀ࡚࠸ࡿ㸬࡛㸪ᣄ⤯཯ᛂࡸ⾑ᰦᙧᡂࢆᢚ࠼ࡿ࡜࠸ࡗࡓྲྀࡾ⤌ ࡇࡢ୙⧊ᕸ࡟ .Uࡢ࢖࢜ࣥࣅ࣮࣒↷ᑕࢆ⾜࠺࡜㸪ࡳࡶ࡞ࡉࢀ࡚࠾ࡾ㸪⏕యእ࡛⾑⟶ෆ⓶⣽⬊ࢆ㎿㏿

ẚ㍑ⓗప࠸↷ᑕ㔞࡛࢘ࢩ⾑⟶ෆ⓶⣽⬊ࡢ᥋╔ᛶࢆ࡟ቑṪࡉࡏࡿᇶᮦ࡜ࡋ࡚ࡶ᭷⏝࡛࠶ࡿ㸬๻ⓗ࡟ᨵၿࡍࡿࡇ࡜ࡀྍ⬟࡛࠶ࡗࡓ㸬୍᪉㸪⾑ᑠ ࡞࠾㸪ᮏ◊✲ࡣᮾி⌮⛉኱Ꮫ኱Ꮫ㝔ࡢ▮ᓥ◊✲ᯈ⢓╔ࡣᮍ↷ᑕ࡜࡯ࡰྠ⛬ᗘ࡛࠶ࡾ㸪⾑ᑠᯈ⢓╔ᐊ࡜ࡢඹྠ◊✲࡛࠶ࡾ㸪▮ᓥ༤ᩥᩍᤵ࡟῝ࡃឤㅰࢆ⥔ᣢࡋࡓࡲࡲ㸪⾑⟶ෆ⓶⣽⬊ࡢ᥋╔ᛶࢆᨵၿࡍ

⏦ࡋୖࡆࡲࡍ㸬ࡿࡇ࡜ࡀྍ⬟࡛࠶ࡗࡓ㸬୍⯡࡟㸪⣽⬊᥋╔ᛶ࡟ඃࢀࡓ⾲㠃ࡣ㸪⾑ᑠᯈ⢓╔ࡶ㉳ࡇࡾࡸࡍ࠸ࡓࡵ㸪ࡇࡢ⤖ᯝ㸱㸬ࡲ࡜ࡵ

ࡣ㠀ᖖ࡟⯆࿡῝࠸ࡶࡢ࡛࠶ࡿ㸬࢖࢜ࣥࣅ࣮࣒↷ᑕ࡟ ࢚ࣞࢡࢺࣟࢫࣆࢽࣥࢢἲ࡟ࡼࡗ࡚స〇ࡉࢀࡓ࣏ࣜ

ࡼࡗ࡚⣽⬊᥋╔ᛶࡀྥୖࡍࡿᶵᵓ࡟ࡘ࠸࡚ࡣᮍࡔ

ங㓟ࢼࣀࣇ࢓࢖ࣂ࣮࡟࢖࢜ࣥࣅ࣮࣒↷ᑕࢆ⾜࠺ࡇ࡜᫂ࡽ࠿࡛ࡣ࡞࠸ࡀ㸪࢖࢜ࣥࣅ࣮࣒↷ᑕ࡟ࡼࡗ࡚᪂

࡛㸪ᢠ⾑ᰦᛶࢆ᭷ࡋ㸪⣽⬊᥋╔ᛶ࡟ඃࢀࡓ⾲㠃ࢆ๰〇ࡓ࡟ᙧᡂࡉࢀࡿⅣ⣲ᵓ㐀ࡀ㉳ᅉࡋ࡚࠸ࡿ࡜⪃࠼࡚ࡍࡿࡇ࡜ࡀ࡛ࡁࡓ㸬௒ᚋ㸪⏕యෆ࡛ࡢ⾑ᾮ㐺ྜᛶࢆホ࠸ࡿ㸬Ỉ࡟ᑐࡍࡿ᥋ゐゅࡣ㸪ࢩ࣮ࢺᙧ≧ࡢ࣏ࣜங౯ࡍࡿ࡜࡜ࡶ࡟㸪ఙ⦰ᛶ㸪⪏ᅽᛶࡢඃࢀࡓࣇ࢓࢖ࣂ࣮

㓟⾲㠃࡛ࡣ r⛬ᗘ࡛࠶ࡿࡀ㸪ࢼࣀࣇ࢓࢖ࣂ࣮࡛

ᵓ㐀ࡢస〇࡟ࡘ࠸࡚ࡶ᳨ウࡋ࡚࠸ࡁࡓ࠸㸬ࡣ㸪⾲㠃࢚ࢿࣝࢠ࣮ࡀྥୖࡋ㸪᥋ゐゅࡣ r⛬

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᪥ᮏ䝞䜲䜸䝺䜸䝻䝆䞊Ꮫ఍Ꮫ⾡ዡບ㈹䜢ཷ㈹䛧䛶㻌
ᕝᓮ 㑣⥴ே㸨㸯㸬ࡣࡌࡵ࡟

䠎䠊◊✲ෆᐜ㻌 ࡇࡢᗘࡣ➨㸱㸱ᅇ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍Ꮫ ࡇࡢࡓࡧཷ㈹ᑐ㇟࡜࡞ࡾࡲࡋࡓ◊✲ࡣ㸪࠶ࡿ⢾⾡ዡບ㈹ࢆ㡬ࡁ㸪ㄔ࡟ගᰤ࡟Ꮡࡌࡲࡍ㸬2010 ᖺ 9㙐࡟ࡼࡗ࡚⣽⬊⭷࡟⤖ྜࡋ࡚࠸ࡿ GPI ࢔࣮ࣥ࢝ᆺ

᭶࡟༤ኈㄢ⛬ಟ஢ࢆ᥍࠼ࡓ᫬ᮇ࡟ࡇࡢࡼ࠺࡞ྡ㄃⭷ ࢱ ࣥ ࣃ ࢡ ㉁ 㸦 Glycosil-phosphatidyl-inositol

࠶ࡿ㈹ࢆཷ㈹࡛ࡁࡓࡇ࡜ࡣ㛗࠿ࡗࡓᏛ⏕⏕άࡢ୍

anchored Protein: GPI-AP㸧ࡢ㐠ືࢆ⣽⬊ᒁᡤࡈ࡜ษࡢⱞປࡀሗࢃࢀࡓࡼ࠺࡞Ẽࡀ࠸ࡓࡋࡲࡍ㸬ࡇࡢ࡟ゎᯒࡋࡓࡶࡢ࡛ࡍ㸬ᚑ᮶◊✲ 1)࡛ࡣ⣽⬊⭷ࢆᵓ

ࡓࡧࡢཷ㈹࡟㝿ࡋࡲࡋ࡚ᮏ⣬㠃ࢆ࠾೉ࡾࡋ࡚⚾ඹᡂࡍࡿࣜࣥ⬡㉁ࡢᣑᩓಀᩘࡀࡏࢇ᩿ᛂຊ㈇Ⲵ࡟ࡼ

ࡢ◊✲ᑐ㇟࠾ࡼࡧཷ㈹ᑐ㇟࡜࡞ࡗࡓ◊✲ࡢෆᐜ࡞ࡗ࡚⣽⬊ᒁᡤⓗ࡟ኚືࡍࡿࡇ࡜ࡀ☜ㄆࡉࢀ࡚࠾ࡾ㸪࡝࡟ࡘ࠸࡚ᚚ⤂௓ࡉࡏ࡚࠸ࡓࡔࡁࡲࡍ㸬⭷ࢱࣥࣃࢡ㉁࡟ᙳ㡪ࢆ୚࠼࡚࠸ࡿࡇ࡜ࡀ♧၀ࡉࢀ ⚾ࡀᡤᒓࡋ࡚࠸ࡿⰪᾆᕤᴗ኱Ꮫࡢ⏕య⤌⧊ᕤᏛ࡚࠾ࡾࡲࡋࡓࡀ㸪ᐇ㝿ࡢᙳ㡪࡟ࡘ࠸࡚ࡣ୙࡛᫂ࡋ

◊✲ᐊ㸦ᕤ⸨◊✲ᐊ㸧࡛ࡣ⾑⟶ࡢ⾑ὶㄪ⠇ᶵᵓ࡟ࡓ㸬ᮏ◊✲࡛ࡣࡑࡢᙳ㡪ࡢ᭷↓ࢆ㛵ࡍࡿ◊✲ࢆ⾜ࡗ࡚࠸ࡲࡍ㸬⾑ὶㄪ⠇ᶵᵓࡢࡼ࠺

ࣇ࢛ࢺࢡ࣑ࣟࢵࢡ⺯ගࢱࣥࣃࢡ㉁ Dronpa ࢆ฼⏝࡞⏕యࡢ࣓࢝ࢽࢬ࣒࡟ࡘ࠸࡚᫂ࡽ࠿࡟ࡍࡿࡓࡵ࡟

ࡋࡓ᪂ࡋ࠸ྍど໬ἲࢆᩚഛࡋ㸪GPI-AP ࡢ㐠ືࢆྍࡣศᏊ࣭⣽⬊ࣞ࣋ࣝ㸪⤌⧊ࣞ࣋ࣝ㸪⏕యࣞ࣋ࣝࡑど໬㸪ゎᯒࢆヨࡳࡓࡶࡢ࡛ࡍ㸬ࢀࡒࢀࡢࢫࢣ࣮࡛ࣝࡢ᳨ドࡀ㔜せ࡛࠶ࡿ࡜⪃࠼㸪 Dronpa ࢆ⏝࠸ࡓྍど໬ἲ࡛ࡣᒁᡤⓗ࡞ UV ග↷ࡑࢀࡒࢀࡢ࡛ࣞ࣋ࣝ◊✲ࢳ࣮࣒ࢆ⦅ᡂࡋࠊ୪⾜ࡋᑕ࡟ࡼࡗ࡚ᒁᡤ㒊఩ࡢࢱࣥࣃࢡ㉁ࡢࡳࢆྍど໬ࡍ࡚◊✲ࢆ㐍ࡵ࡚࠸ࡲࡍ㸬⚾ࡣࡑࡢ୰࡛ࡶศᏊ࣭⣽ࡿࡇ࡜ࡀྍ⬟࡛ࡍ㸬ᒁᡤⓗ࡟ྍど໬ࡍࡿࡇ࡜࡛ྍ

⬊࡛ࣞ࣋ࣝࡢ⾑⟶ไᚚᶵᵓ࡟ࡘ࠸࡚ࡢ◊✲ࢳ࣮࣒ど໬ࡋࡓࢱࣥࣃࢡ㉁ࡢ㐠ືࡢ㌶㊧ࢆ㏣࠺ࡇ࡜ࡀྍ

࡟㓄ᒓࡉࢀ࡚࠾ࡾ㸪≉࡟⣽⬊ෆศᏊࡢ㐠ືࡢྍど⬟࡜࡞ࡾࡲࡍ㸬ᮏ◊✲࡛ࡣ㑇ఏᏊᕤᏛⓗᡭἲࢆ⏝໬࠾ࡼࡧほᐹࢆᢸᙜࡋ࡚࠸ࡲࡍ㸬࠸࡚ Dronpa ࡢሷᇶ㓄ิ࡟ GPI-AP ࡟ྵࡲࢀࡿ≉ᐃ ⾑⟶ෆ⓶⣽⬊࡟ࡣከ✀ከᵝ࡞ࢱࣥࣃࢡ㉁ࡀᏑᅾ

ࡢሷᇶ㓄ิࢆ⤖ྜࡉࡏ㸪GPI-AP ᆺࡢ Dronpa ࢆ⣽ࡋࡲࡍࡀ㸪୍㒊ࡢࢱࣥࣃࢡ㉁ࡣ⣽⬊ෆࡢศᕸࡀᒁ

⬊⭷⾲㠃࡟Ⓨ⌧ࡉࡏࡿ㑇ఏᏊࢆసᡂࡋࡲࡋࡓ㸬ࡇᡤⓗ࡟㞟୰ࡍࡿࡼ࠺࡞୙ᆒ୍࡞ศᕸࢆ࡞ࡍ㸦ᴟᛶࡢ㑇ఏᏊࢆᑟධࡋࡓ⾑⟶ෆ⓶⣽⬊࡟ࡏࢇ᩿ᛂຊࢆ

໬ࡍࡿ㸧ሙྜࡀ࠶ࡾࡲࡍ㸬ࡲࡓᒁᡤⓗ࡟ࢱࣥࣃࢡ㈇Ⲵࡋ㸪ྍど໬ࡋࡓ GPI-AP ࡢᣑᩓಀᩘࢆ㉁ࡢάᛶࣞ࣋ࣝࡀ␗࡞ࡿࢱࣥࣃࢡ㉁ࡶ☜ㄆࡉࢀ࡚ࡓ࡜ࡇࢁ㸪⣽⬊ᒁᡤ㒊఩㸦ୖὶഃ⣽⬊࿘⦕㒊㸧࡟࠸ࡲࡍ㸬࠸ࡃࡘ࠿ࡢ୙ᆒ୍࡞ࢱࣥࣃࢡ㉁ࡢศᕸ࠾

࠾࠸࡚ GPI-AP ࡢᣑᩓಀᩘࡣ୍᫬ⓗ࡟ 1.2 ಸ⛬ᗘୖࡼࡧάᛶࣞ࣋ࣝࡢ㐪࠸ࡣෆ⓶⣽⬊ࡢ⏕⌮ᶵ⬟࡜ࡢ᪼ࡍࡿࡇ࡜ࢆぢฟࡋࡲࡋࡓ㸬ᮏ◊✲⤖ᯝࡣ⭷ࢱࣥ㛵㐃ࡀ♧၀ࡉࢀ࡚࠸ࡲࡍࡀ㸪⏕⌮ᶵ⬟ࡀ᫂ࡽ࠿࡛

ࣃࢡ㉁ࡢ㐠ືࡀ㸪ᚑ᮶◊✲࡛ሗ࿌ࡉࢀࡓࣜࣥ⬡㉁࡞࠸ᴟᛶ໬ࡶሗ࿌ࡉࢀ࡚࠸ࡲࡍ㸬ࡇࡢࡼ࠺࡞⣽⬊ࡢᣑᩓ≉ᛶࡢኚ໬࡟ࡼࡿᙳ㡪ࢆཷࡅ࡚࠸ࡿࡇ࡜ࢆ

ෆ࡛ࡢศᕸࡀᴟᛶ໬ࡋ࡚࠸ࡿࢱࣥࣃࢡ㉁ࡢᛶ㉁ࢆ

♧ࡍࡶࡢ࡛࠶ࡾ㸪࠿ࡘ⭷ࢱࣥࣃࢡ㉁ࡣࣜࣥ⬡㉁௨

⣽⬊ෆࡢᒁᡤࡈ࡜࡟ゎᯒࡍࡿࡇ࡜ࡀ⚾ඹࡢ◊✲ᑐእࡢᅉᏊ࠿ࡽ㐠ືࡢไᚚࢆཷࡅ࡚࠸ࡿࡇ࡜ࢆ♧၀㇟࡛࠶ࡾࡲࡍ㸬㻌ࡍࡿࡶࡢ࡛ࡋࡓ㸬ᮏ◊✲⤖ᯝࡣࡏࢇ᩿ᛂຊ࡟ࡼࡾ

㸨ᐃࡍࡿࡓࡵ࡟㸪Ⱚᾆᕤᴗ኱Ꮫ኱Ꮫ㝔 ᕤᏛ◊✲⛉ ᶵ⬟ไᚚࢩࢫࢸ࣒ᑓᨷ [ࠛ135-8548 ᮾி㒔Ụᮾ༊㇏Ὢ 3-7-5]

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㸱㸬Ꮫ⾡ዡບ㈹ࢆཷ㈹ࡋ࡚
 ◊✲ᐊ࡟ᡤᒓࡋࡓ 2004 ᖺ௨᮶㸪⚾ࡢ⯆࿡ࡣࠕ⾑⟶ࡢ⾲㠃ࢆ⮬⏤࡟⛣ືࡋ࡚࠸ࡿ⣽⬊⭷ࢱࣥࣃࢡ㉁ࡣὶࢀ㈇Ⲵ࡟ࡼࡿࡏࢇ᩿ᛂຊ࡟ࡼࡗ࡚࡝ࡢࡼ࠺࡞
ᙳ㡪ࢆཷࡅࡿࡢ࠿ࠖ࡟࠶ࡾࡲࡋࡓ㸬⭷ࢱࣥࣃࢡ㉁ࡢ㐠ືࢆྍど໬ࡍࡿࡓࡵ࡟㑇ఏᏊᕤᏛࡢᐇ㦂タഛࢆࢮࣟ࠿ࡽᩚഛࡍࡿࡇ࡜࠿ࡽጞࡵ㸪2006 ᖺ࡟୍ᗘDG-GPI ࡢ㑇ఏᏊࡢྜᡂ࡟╔ᡭࡋࡲࡋࡓࡀ㸪ሷᇶ㓄ิࡢヲ⣽タィࡀᝏ࠿ࡗࡓࡼ࠺࡛㸯ᖺ㛫ᡂᯝࢆฟࡏ࡞࠸ⱞࡋ࠸᫬ᮇࡀ࠶ࡾࡲࡋࡓ㸬2008 ᖺ㸰ᗘ┠ࡢᣮᡓ࡛⣽⬊⭷࡛ࡢ⺯ගࢆ☜ㄆࡋࡓ࡜ࡁ࡟ࡣ㧗ᥭឤࢆᢚ࠼ࡽࢀࡎᐷ௜ࡅ࡞࠿ࡗࡓࡇ࡜ࢆぬ࠼࡚࠸ࡲࡍ㸬ḟ➨࡟ࠕࡇࡢ◊✲࡛຾㈇ࡋࡓ࠸ࠖ࡜Ꮫ⾡ዡບ㈹࡟
ᣮᡓࡍࡿẼᣢࡕࡀᙉࡃ࡞ࡾࡲࡋࡓ㸬 ዡບ㈹࡬ࡢᣮᡓࡣ➨㸱㸰ᅇᏛ఍࠿ࡽ㸰ᗘ┠࡛ࡋࡓ㸬ᤵ㈹ᘧ࡛⚾ࡢྡ๓ࡀ࿧ࡤࢀࡓ࡜ࡁࡣ㸪㦫ࡁ࡜
2004 ᖺ࠿ࡽࡢດຊࡀᐇࡗࡓࡇ࡜࡬ࡢឤື࡛ᡭࡀ
㟈࠼ࡲࡋࡓ㸬ᤵ㈹ᘧ࡛ࡣ⚾㸯ேࡁࡾ࡛ࡋࡓࡀ㸪㸴ᖺ㛫࡛㸯㸲ேࡶࡢᏛ⏕ࡀᮏ◊✲࡟ᦠࢃࡗ࡚ࡁࡓࡇ
࡜࡟Ẽࡀ௜ࡁ㸪ࡇࡢឤືࢆඹ᭷ࡋࡓ࠸࡜ᙉࡃឤࡌ
࡚࠸ࡲࡍ㸬⚾ࡢ◊✲⇕ࡀ⊂ࡾṌࡁࡋ࡚㸪Ꮩ⊂ࢆឤࡌࡿࡇ࡜ࡶከࠎ࠶ࡾࡲࡋࡓࡀ㸪ඹ࡟◊✲ࡋ࡚ୗࡉࡓࡇ࡜ࡣ㸪࠿ࡅࡀ࠼ࡢ࡞࠸⤒㦂࡛࠶ࡾ㸪኱ࡁ࡞⮬ಙ࡜࡞ࡾࡲࡋࡓ㸬㸴ᖺ࡟Ώࡿ⚾ࡢ⤒㦂࡜ࡇࡢᰤ㄃
࠶ࡿ㈹ࢆ◊✲ᐊࡢṔྐࡢ㑇ࡋ㸪ࠕㅉࡵ࡞࠸ࠖࠕດ
ຊࡣሗࢃࢀࡿࠖ࡜࠸࠺ᖹซ࡛ࡣ࠶ࡿࡅࢀ࡝ࡶ࡜࡚
ࡶ኱ษ࡞ࡇ࡜ࢆᚋୡ࡟ఏ࠼࡚࠸ࡇ࠺࡜ᛮ࠸ࡲࡍ㸬㸲㸬࠾ࢃࡾ࡟ ⚾ࡢࡼ࠺࡞ᮍ⇍⪅࡟ᑐࡋ࡚㸴ᖺ༙ࡶࡢ㛫ᚚຓゝ࣭ᚚᣦᑟୗࡉࡗࡓᣦᑟᩍဨࡢⰪᾆᕤᴗ኱Ꮫᕤ⸨ዡᩍᤵ࡟῝ࡃឤㅰ⮴ࡋࡲࡍ㸬ࡲࡓ㸪ᮏ◊✲㐙⾜࡟࠶ࡓࡾⰪᾆᕤᴗ኱Ꮫ෸ᩍᤵ℈ᓮၨኴඛ⏕࡟ࡣ㑇ఏᏊᕤᏛࢆᩚഛࡍࡿࡓࡵࡢࡁࡗ࠿ࡅࢆసࡗ࡚㡬ࡁ㸪ࡲࡓ⏕໬Ꮫⓗ࡞ศ㔝࡛ᩘከࡃࡢᣦᑟࢆ㡬ࡁࡲࡋࡓࡇ࡜ᚰ࠿ࡽᚚ♩⏦ࡋୖࡆࡲࡍ㸬 ᭱ᚋ࡟⚾ඹࡢ◊✲ࢆࡇࡢࡼ࠺࡞ྡ㄃࠶ࡿ㈹࡟ᚚ
᥎⸀ୗࡉ࠸ࡲࡋࡓ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍Ꮫ⾡
ዡບ㈹ᑂᰝဨࡢⓙᵝ᪉࡟ࡇࡢሙࢆ࠾೉ࡾࡋ࡚῝ࡃᚚ♩⏦ࡋୖࡆࡲࡍ㸬ᩥ ⊩1) Butler PJ et al., Am J Physiol Cell Physiol. 280(4):C962-9, 2001.

ࡗࡓ᪉ࠎ࡟ᨭ࠼ࡽࢀ㸪㐣ཤࡢኻᩋ࡟⮑ࡍࡿࡇ࡜࡞

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➨㸱㸱ᅇ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ᖺ఍ࢆ㛤ദࡋ࡚ᖺ఍㛗 Ặᐙ ᘯ* 㐣᪥ࡣ࿴ගᕷ⌮◊࡟࡚㛤ദ࠸ࡓࡋࡲࡋࡓ➨୍ᅇᅜ㝿ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ࢩ࣏ࣥࢪ࣒࢘㸪➨ 33 ᅇ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ᖺ఍࡛ࡣ㸪ࡈᨭ᥼ࡈ༠ຊ኱ኚ࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓ㸬ᚰ࠿ࡽឤㅰ࠸ࡓࡋ࡚࠾ࡾࡲࡍ㸬
 6 ᭶ 2 ᪥㸪3 ᪥㸪4 ᪥ࡢ 3 ᪥㛫ࡣᬕኳ࡟ᜨࡲࢀ㸪ཧຍ⪅ࡶ 150 ྡ࡟ཬࡧࡲࡋࡓ㸬⣲ᬕࡽࡋ࠸Ⓨ⾲ࡀᩘከࡃ࠶ࡾ㸪㉁␲ᛂ⟅ࡶάⓎ࡟⾜ࢃࢀࡲࡋࡓ㸬᠓ぶ఍࡛ࡣཧຍ⪅ྠኈࡀ┤᥋఍ヰ࡛ࡁ㸪་ᕤ㐃ᦠࢆࡉࡽ࡟㐍ࡵࡿࡇ࡜ࡀ࡛ࡁࡓࡼ࠺࡟ᛮ࠸ࡲࡋࡓ㸬 ᫬㛫ࡀ࠿࠿ࡾࡲࡋࡓࡀᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࡢ DVD ࡀฟ᮶ୖࡀࡾࡲࡋࡓࡢ࡛㸪ࡈᕼᮃࡢ᪉࡟ࡣ㏦௜
ࡉࡏ࡚࠸ࡓࡔࡁࡲࡍ㸬ⓙᵝࡢ௒ᚋࡢ◊✲ࡢ࠾ᙺ࡟ࡓ࡚ࡤ࡜࡚ࡶ࠺ࢀࡋ࠸࡛ࡍ㸬 ࡇࡇ࡟᠓ぶ఍࡛ࡢ఍ဨࡢⓙᵝࡢ෗┿ࢆࡈᢨ㟢࠸ࡓࡋࡲࡍࠋ࡝࠺࠿࠾ᴦࡋࡳࡃࡔࡉ࠸ࠋ

㸨ᮾிປ⅏⑓㝔࣭⬻⚄⤒እ⛉ >ࠛ ᮾி㒔኱⏣༊኱᳃༡ @᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ㸦㟁Ꮚ∧㸧 ➨  ᕳ ➨  ྕ  

 7 ᭶ 17 ᪥㏆␥⬻⾑⟶እ⛉◊✲఍࡟࡚㸪ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍࡛ࡢ⬻ື⬦⒗ࢭࢵࢩࣙࣥࡢሗ࿌ࢆ࠸
ࡓࡋࡲࡋࡓ㸬㠀ᖖ࡟㧗࠸ホ౯ࢆཷࡅࡲࡋࡓ㸬௒ᚋࡣ CFD ࡀ௒ᚋ⬻ື⬦⒗ࡢ⮫ᗋࡢሙ࡟࠾࠸࡚࡝ࡢࡼ
࠺࡞ᙺ๭ࢆᢸ࠺࠿㸪࡛ࡁࢀࡤ⾑⟶ෆእ⛉Ꮫ఍࡜༠ຊࡀ࡛ࡁࢀࡤࡼ࠸࡜ᚰ࠿ࡽᛮ࠸ࡲࡋࡓ㸬 NPO ἲே᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࡣ㸪᫖ᖺࡢ Journal of Biorheology㸦JBR㸧ࡢⓎหࡑࡋ࡚௒
ᖺࡢᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࢆ஌ࡾ㉺࠼࡚᪂ࡓ࡞୍Ṍࢆ㋃ࡳฟࡍࡓࡵࡢ‽ഛࡀ࡛ࡁࡓẼࡀࡋࡲࡍ㸬௒ᚋࡢㄢ㢟ࡣ࠸࠿࡟ JBR ࡬ࡢᢞ✏ࢆ㞟ࡵࡿ࠿࡜࠸࠺ࡇ࡜ࡔࢁ࠺࡜ᛮ࠸ࡲࡍ㸬ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ဨࡢ⣲ᬕࡽࡋ࠸ㄽᩥࡀ㞟ࡲࡿ࡜ࡼ࠸࡜ᛮࡗ࡚࠾ࡾࡲࡍ㸬⚾ࡶ⬻ື⬦⒗ࡢ⥲ㄝࢆᢞ✏ࡋࡓ࠸࡜⏝ពࡋ࡚࠸ࡿ
࡜ࡇࢁ࡛ࡍ㸬 ᮶ᖺࡶ⣲ᬕࡽࡋ࠸Ꮫ఍ࡀ࡛ࡁࡿࡼ࠺♳ࡗ࡚࠾ࡾࡲࡍ㸬ᖹᡂ 22 ᖺ 10 ᭶ྜྷ᪥➨୍ᅇᅜ㝿ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ࢩ࣏ࣥࢪ࣒࢘
➨ 33 ᅇ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ᖺ఍
఍㛗 Ặᐙ ᘯ➨୍ᅇᅜ㝿ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ࢩ࣏ࣥࢪ࣒࢘࡜➨ 33 ᅇ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ᖺ఍ࡢࣉࣟࢢ࣒ࣛ
ࢆḟ㡫௨㝆࡟ᥖ㍕ࡉࡏ࡚㡬ࡁࡲࡍࠋ

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The First International Symposium of Biorheology (June 2, 2010)
Morning Session
9:00-10:20
Chair: Motoaki Sugawara
1. “Oxidative stress, endothelium-dependent relaxation and vascular gap junctions” by David Edwards, Cardiff
University, UK
2. “Chaotic analysis of vasomotion” by Dimitris Parthimos, Cardiff University, UK

10:20-10:30 Coffee break

10:30-12:00
Chair: Kazuo Tanishita
3. “Comparative Biophysics of Mechanotransduction: from bacteria to endothelial cells” by Masahiro Sokabe,
Nagoya University, Japan
4. "Signaling of vascular smooth muscle contraction" by Yoh Takuwa, Kanazawa University, Japan

12:00-13:30 Lunch time

Afternoon Session
13:30-15:40
Chair: Tomokatsu Hori
5. “Arterial wall mechanics using a constituent-based approach” by Nikos Stergiopulos, Lausanne, Switzerland
6. “Mechanism of aneurysm initiation and rupture” by Hui Meng, State University of New York, USA
7. “Cerebral aneurysm as a chronic inflammatory disease in arterial bifurcation induced by shear stress” byTomohiro Aoki, Kyoto University, Japan

15:40-15:50 Coffee break

15:50-17:10
Chair: Mari Ohshima
8. “Modelling of flow and thrombus formation in aneurysms” by Kenjiro Shimano, Tokyo City University, Japan
9. “CFD after stenting and coiling of aneurysm” by Minsuok Kim, Universitat Pompeu Fabra, Spain

18:00-20:00 Welcome Party

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ྡྂᒇ኱Ꮫ་Ꮫ㒊ಖ೺Ꮫ⛉὾ᯇ་⛉኱Ꮫ་Ꮫ㒊ᨺᑕ⥺⛉㸪♒⏣἞ኵⓎ⾲ ࢥ࢖ࣝሰᰦሢࡢ≀⌮≉ᛶ࡟㛵ࡍࡿ⌮ㄽ࡜ᐇ㦂࡟ࡼࡿ᳨ドᯇᒣ㉥༑Ꮠ⑓㝔⬻⚄⤒እ⛉㸪Ṋᬛ᫛ᙪ&RIIHH%UHDNィ ᢏ⾡ࡢ㛤Ⓨ࡜ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮࡬ࡢᛂ⏝ᗙ㛗㸸ᅵᶫᩄ᫂㸪ᒣᮏ㝯ኵⓎ⾲ ࣐࢖ࢡࣟࢳࣕࣥࢿࣝ࢔ࣞ࢖ࡢࣞ࢜ࣟࢪ࣮
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Ⓨ⾲ ཯ᑕᖸ΅ศගἲࢆ฼⏝ࡋࡓศᏊ㛫┦஫స⏝ᐃ⿦⨨ࢥࢽ࣑࢝ࣀࣝࢱ࢜ࣉࢺओ㸪ᰩཎ⩏୍Ⓨ⾲ ㄏ㟁ศගἲ࡟ࡼࡿ⾑ᾮจᅛึᮇ㐣⛬ࡢほ ࡜จᅛ㛤ጞ᫬㛫ࡢ᥎ᐃἲ
ࢯࢽ࣮㸦ᰴ㸧ඛ➃࣐ࢸࣜ࢔ࣝ◊✲ᡤࣛ࢖ࣇࢧ࢖࢚ࣥࢫ◊✲㒊㸪ᯘ⩏ே᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍⥲఍᫨ఇࡳ
-%5 ⦅㞟఍㆟㕥ᮌᱵኴ㑻グᛕ࣮࣍ࣝ  㝵኱ࢭ࣑ࢼ࣮ᐊ  Ꮫ⾡ዡບ㈹බເⓎ⾲ᗙ㛗㸸㇂ୗ୍ኵ
Ⓨ⾲   ศ ໬⢝ရࡢ౑⏝ឤ࡟ಶேᕪࢆⓎ⏕ࡉࡏࡿ⏕యᅉᏊᰴ ࣀ࢚ࣅ࢔◊✲㛤Ⓨ㒊㸪ᑠụᚭⓎ⾲   ศ ࣐࢖ࢡࣟὶయࢹࣂ࢖ࢫ࡟ࡼࡿᚤᑠ⣽⬊⎔ቃࡢไᚚ࡜ከ⣽⬊⤌⧊໬ࡢ᳨ウ៞᠕⩏ሿ኱Ꮫ⌮ᕤᏛ㒊ࢩࢫࢸ࣒ࢹࢨ࢖ࣥᕤᏛ⛉㸪㡲⸨ுⓎ⾲   ศ ࢚ࣞࢡࢺࣟࢫࣆࢽࣥࢢࣇ࢓࢖ࣂ࣮ࢆ⏝࠸ࡓ⾑ᾮ㐺ྜᛶᮦᩱ࡬ࡢᛂ⏝⌮໬Ꮫ◊✲ᡤᮾி⌮⛉኱Ꮫ኱Ꮫ㝔㸪⏣୰ಇ⾜Ⓨ⾲   ศ ࡏࢇ᩿ᛂຊୗ࡟࠾ࡅࡿ⾑⟶ෆ⓶⣽⬊ࡢ⣽⬊⭷ࢱࣥࣃࢡ㉁㐠ືࡢ ᐃⰪᾆᕤᴗ኱Ꮫ኱Ꮫ㝔ᕤᏛ◊✲⛉㸪ᕝᓮ㑣⥴ேⓎ⾲   ศ ࢥ࣮ࣛࢤࣥ࡬ࡢ⾑ᑠᯈ⢓╔ᣲືࡢὶࢀ౫Ꮡᛶ࡜㧗ࡏࢇ᩿⤒㦂ᚋࡢ⾑ᑠᯈ⢓╔≉ᛶኚ໬Ⱚᾆᕤᴗ኱Ꮫࢩࢫࢸ࣒⌮ᕤᏛ㒊⏕࿨⛉Ꮫ⛉㸪Ώ㑓ᐉኵⓎ⾲   ศ ὶື」ᒅᢡἲ࡟ࡼࡿ࢔࣑ࣟ࢖ࢻᑠ⥺⥔ᙧᡂࡢ㏣㊧໭ᾏ㐨኱Ꮫ኱Ꮫ㝔㸪Ἑྜඃ୍
Ⓨ⾲   ศ ⏕་⒪⏝⤌⧊ࡢᇵ㣴㐣⛬࡟࠾ࡅࡿ➨஧㧗ㄪἼⓎ⏕ගࡢኚ໬
኱㜰኱Ꮫ኱Ꮫ㝔ᇶ♏ᕤᏛ◊✲⛉㸪๓ཎ㕥Ꮚ&RIIHH%UHDN⬻ື⬦⒗ࡢ◊✲᭱๓⥺ ,,ᗙ㛗㸸῝స࿴᫂㸪ᗉᓥṇ᫂Ⓨ⾲ ⬻ື⬦⒗ෆࡢ⾑ὶࣃࢱ࣮ࣥ࡜⾑ᑠᯈจ㞟ࡢ㛵㐃ᛶ࡟㛵ࡍࡿᩘ್ゎᯒⓗ◊✲㸦ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄽᩥ㈹ཷ㈹ㅮ₇㸸 ศ㸧ᮾி㒔ᕷ኱Ꮫ㸪ᓥ㔝೺ோ㑻Ⓨ⾲ ࢫࢸࣞ࢜㹎㹇㹔࡜ࡢẚ㍑࡟ࡼࡿ⬻ື⬦⒗⾑ὶゎᯒࡢ⢭ᗘ࡜᱁Ꮚ౫Ꮡᛶࡢ᳨ド



 

ᮾி኱ᏛᕤᏛ㒊㸪኱ᓥࡲࡾ
Ⓨ⾲ ᢿືὶ୰࡛⭾ᙇ࣭཰⦰ࡍࡿ⬻ື⬦⒗ෆࡢὶࢀᵓ㐀Ⱚᾆᕤ኱㸪ᒸ⏣ᖾ୍㑻Ⓨ⾲ ⾑⟶ࣂ࢖࢜ࣔࢹࣝࢆ⏝࠸ࡓ 3,9 ࡟ࡼࡿ⒗ෆࢥ࢖ࣝ࿘ࡾࡢ⾑ὶゎᯒᮾ໭኱Ꮫὶయ⛉Ꮫ◊✲ᡤ㸪ኴ⏣ಙⓎ⾲ ⾑⟶⣔⾑⟶ቨࡢᙎຊ≉ᛶ࡜࣑ࢽື⬦⒗
⪷㞔ࢡࣜࢫࢺࣇ࢓࣮኱Ꮫࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ㒊㸪ከ⨶ᑿ⠊㑻Ⓨ⾲  *HRPHWU\DQG+HPRG\QDPLFVWR$VVHVVWKH5LVNRI,QWUDFUDQLDO$QHXU\VP5XSWXUH
0LQVXRN.LP&RIIH%UHDN⬻ື⬦⒗ࡢ◊✲᭱๓⥺ ,,,ᗙ㛗㸸ර㢌᫂ኵ㸪ᒣཱྀ㝯ᖹⓎ⾲ 1)N% ࡣ⬻ື⬦⒗ᙧᡂࡢ୺せ࡞௰௓ᅉᏊ࡛࠶ࡿ
㸦ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄽᩥ㈹ཷ㈹ㅮ₇㸸 ศ㸧ி㒔኱Ꮫ኱Ꮫ㝔་Ꮫ◊✲⛉⬻⚄⤒እ⛉Ꮫྠ⚄⤒⣽⬊⸆⌮Ꮫ㸪㟷ᮌ཭ᾈⓎ⾲ ᪂つ࣐࢘ࢫ⬻ື⬦⒗ࣔࢹࣝࢆ⏝࠸ࡓ㸪⬻ື⬦⒗࡟࠾ࡅࡿ࣐ࢡࣟࣇ࢓࣮ࢪࡢᙺ๭
ከ⏣ᜨ᭙㸪6DQ)UDQFLVFR86$
Ⓨ⾲ ࣛࣅࢵࢺㄏⓎ⬻ື⬦⒗ෆࡢቨ㠃ࡏࢇ᩿ᛂຊศᕸ࡜ 003V ࡜ L126 Ⓨ⌧ᕸ៞᠕⩏ሿ኱Ꮫ኱Ꮫ㝔⌮ᕤᏛ◊✲⛉㸪⏣அୖဴஓ
Ⓨ⾲ ,QWUDFUDQLDODQHXU\VPLPSDLUHGYDVFXODUUHVSRQVHWRKHPRG\QDPLFLQVXOW+XL0HQJ1HZ<RUN86$
Ⓨ⾲ ࣛࢵࢺ⬻ື⬦⒗ࣔࢹࣝ࡟࠾ࡅࡿ࣑ࢿࣛࣝࢥࣝࢳࢥ࢖ࢻཷᐜయࡢᙺ๭࡟ࡘ࠸࡚
ᚨᓥ኱Ꮫ⬻⚄⤒እ⛉㸪ከ⏣ᜨ᭙Ⓨ⾲ 3DUDGLJP VKLIW RI WKH PDQDJHPHQW RI EUDLQ DQHXU\VP  )URP VLPSOH UHSDLU WRFRPSUHKHQVLYHPDQDJHPHQW$NLUD7DNDKDVKL㸪ᮾ໭኱Ꮫ
᠓ぶ఍



 

➨  ᪥┠㸦 ᭶  ᪥㸧9DVFXODU6FLHQFH,,ᗙ㛗㸸ᒣᮏᕼ⨾Ꮚ㸪㛵┾బᏊⓎ⾲ ⾑ᑠᯈࡢ⢓╔ຊ࡜ࣇ࢛ࣥࣅࣝࣈࣛࣥࢻᅉᏊࡢຊᏛⓗ≉ᛶࡢࡏࢇ᩿౫Ꮡᛶ
៞኱㝔㸪㉺⏣῱Ⓨ⾲ ⣽㟼⬦⥙ࢆ௓ࡍࡿୗ⫥࡬ࡢ㓟⣲౪⤥໭኱㸪ᑠᒣᐩᗣ
Ⓨ⾲ ㄏ㟁Ὃື࡟ࡼࡿ⣽⬊ࣃࢱ࣮ࢽࣥࢢᢏ⾡ࡢ㛤Ⓨ࡜⤌⧊ᕤᏛ࡬ࡢᛂ⏝៞኱㝔⌮ᕤ㸪ᑠᯘဴஓ
Ⓨ⾲  ⾑⟶ෆ⓶⣽⬊ࡢ  ḟඖࢿࢵࢺ࣮࣡ࢡᙧᡂ࡟ཬࡰࡍᐃᖖཬࡧᢿືࡏࢇ᩿ᛂຊࡢᙳ㡪៞᠕⩏ሿ኱Ꮫ኱Ꮫ㝔⌮ᕤᏛ◊✲⛉㸪㜿㒊㡰⣖9DVFXODU6FLHQFH,,,
ᗙ㛗㸸ᮃ᭶⢭୍㸪ෆᮧຌⓎ⾲ ᛴ⤠ࡾ㒊ࢆࡶࡘὶ㊰ෆࢆὶࡉࢀࡿ⢏Ꮚࡢ㐠ື࡟ᑐࡍࡿ㉥⾑⌫ࡢᙳ㡪㛵す኱Ꮫࢩࢫࢸ࣒⌮ᕤᏛ㒊㸪⛅Ọ๛Ⓨ⾲ ⬻⾑⟶἞⒪⏝ࡢ FORVHGFHOO ࢫࢸࣥࢺࡢ࣓ࢵࢩࣗᵓ㐀࡟ࡼࡿຊᏛⓗ≉ᛶࡢኚ໬
៞᠕⩏ሿ኱Ꮫ኱Ꮫ㝔⌮ᕤᏛ◊✲⛉㸪ṇᯘᗣᏹⓎ⾲ άື᫬ࡢ୰኱⬻ື⬦⾑ὶἼᙧ⚄ዉᕝᕤ⛉኱Ꮫ࣭๰㐀ᕤᏛ㒊㸪ᯇᑿᓫⓎ⾲ ᒁᡤὶᇦࡢ஺ឤ⚄⤒ᨭ㓄࡜⬨㧊ᦆയ࡟ࡼࡿᚠ⎔ㄪ⠇࡬ࡢᙳ㡪໭ᾏ㐨ᩥᩍ኱Ꮫ࣭ே㛫⛉Ꮫ㒊࣭⌮Ꮫ⒪ἲᏛ⛉㸪㣤⏣⣖ᏊⓎ⾲ ㄏ㟁ศගἲ࡟ࡼࡿ⾑ᾮจᅛᐃ࡜⢾ᒀ⑓࡬ࡢᛂ⏝ᮾி་⛉ṑ⛉኱ᏛෆศἪ௦ㅰෆ⛉ෆᮧຌ
&RIIHH%UHDN 㣗ရࡢࣞ࢜ࣟࢪ࣮
ᗙ㛗㸸኱᳃⋹Ꮚ㸪బ⸨ᜨ⨾ᏊⓎ⾲ ື⬦◳໬ᛶ⑌ᝈ࡜ᢠ㓟໬㣗ရ
NH\QRWHOHFWXUHPLQ Ᏹ㒔ᐑ኱Ꮫᩍ⫱Ꮫ㒊㸪኱᳃⋹ᏊⓎ⾲ 㨶⫗࡜㭜⫗ࡢΰྜ⇕ࢤࣝࡢ≀ᛶ㛗ᓮ኱㝔⏕⏘⛉Ꮫ㸪ྜྷඖᱻ
Ⓨ⾲ ྛ✀⃦⢊ࢤࣝ࡜ࢦ࣐㇋⭉ࡢຊᏛ≉ᛶ࡜㣗ឤ࡟ࡘ࠸࡚
᪂₲┴❧኱Ꮫ㸪బ⸨ᜨ⨾Ꮚ࣏ࢫࢱ࣮ࢭࢵࢩࣙࣥ㸦 ₇㢟㸧࣏ࢫࢱ࣮⬡㉁஧㔜⭷ࡢᦂࡽࡂ
⩌኱ᕤ㝔ୗ⏣࿴๎ ࣏ࢫࢱ࣮࢔ࣝࢠࣥ㓟࢝ࣝࢩ࣒࢘ࢤࣝࡢගᏛ␗᪉ᛶ
⩌㤿኱Ꮫ኱Ꮫ㝔ᕤᏛ◊✲⛉⣽㇂ዉὠᏘ 



 

࣏ࢫࢱ࣮'1$ Ỉ⁐ᾮࡢ஝⇱㐣⛬ࡢࢲ࢖ࢼ࣑ࢡࢫ
⩌㤿኱㝔ᕤ⊦⊁ᚭᖹ ࣏ࢫࢱ࣮஧ᡂศ⁐ᾮ୰ࡢ㓄ྥࡋࡓ㧗ศᏊ㙐ࡢ⇕ᦂࡽࡂ⩌㤿኱ᕤⓒ⏣⿱♸ ࣏ࢫࢱ࣮ගᏛ␗᪉ᛶࢆᣢࡘ࢟ࢺࢧࣥࣁ࢖ࢻࣟࢤࣝ⏕ᡂࡢࢲ࢖ࢼ࣑ࢡࢫ
ᐩ⏣ዉ⥴Ꮚ ࣏ࢫࢱ࣮ୖୗ᣺ືࡍࡿᯈୖࡢ࣒ࢳࣥሢࡢ㐠ື⪷㞔ࢡࣜࢫࢺࣇ࢓࣮኱Ꮫࣜࣁࣅࣜࢸ࣮ࢩࣙࣥᏛ㒊ከ⨶ᑿ⠊㑻 ࣏ࢫࢱ࣮5,&6 ࡟ࡼࡿ⾑ᑠᯈ⣽⬊ࢩ࣑࣮ࣗࣞࢱࡢ㛤Ⓨᮾᾏ኱Ꮫ୐⃝ὒᖹ ࣏ࢫࢱ࣮ከ⢾㢮⁐ᾮࡢᗘ໙㓄ୗ࡟࠾ࡅࡿศᏊᣑᩓ

ᮾᾏ኱Ꮫ⌮Ꮫ㒊≀⌮Ꮫ⛉႐ከ⌮⋤ ࣏ࢫࢱ࣮㸷⋞⡿㣤ࡢ≀ᛶ࡜ᐁ⬟ホ౯࡟ཬࡰࡍຍỈ㔞࡞ࡽࡧ࡟⢭ⓑ⡿ΰྜẚࡢᙳ㡪㸦ឡᅜᏛᅬ▷኱㸪ᖹᑿ࿴Ꮚ㸧  ศ ᫨ఇࡳ
㸦%5IRUXP 㐠Ⴀጤဨ఍㸪㕥ᮌᱵኴ㑻ᑠ఍㆟ᐊ㸪%㸤5 ⦅㞟఍㆟㸪㕥ᮌᱵኴ㑻グᛕ࣮࣍ࣝ  㝵኱ࢭ࣑ࢼ࣮ᐊ㸧ᒸᑠኳ㈹ཷ㈹ㅮ₇ᗙ㛗㸸Ლ㇂ᩥᙪ
ࠗ㢁ື⬦࢚ࢥ࣮࠿ࡽᚓࡽࢀࡿᚰ⾑⟶ᶵ⬟᝟ሗ̺:DYH,QWHQVLW\̽࠘ጲ㊰⊂༠኱Ꮫ⮫ᗋᕤᏛ⛉㸪Ⳣཎᇶ᫭
㧗ศᏊࣞ࢜ࣟࢪ࣮
ᗙ㛗㸸႐ከ⌮⋤㸪㈅ཎ┿Ⓨ⾲  ኚᛶ࢔ࣝࣈ࣑ࣥࡢจ㞟యᙧᡂࡣ⾑୰࣌ࣉࢳࢻ࡜ࡢ࢔ࣟࢫࢸࣜࢵࢡ⤖ྜ࡟ࡼࡗ࡚ไᚚࡉ
ࢀࡿࢩࢫ࣓ࢵࢡࢫᰴᘧ఍♫୰ኸ◊✲ᡤ㸪㧗ᶫⱥᶞ
Ⓨ⾲ 㧗ศᏊ㙐ࡢ࣐࢖ࢡࣟࣞ࢜ࣟࢪ࣮࡜ᾮᬗࢤࣝᙧᡂ
⩌㤿኱ᕤ㸪ᒣᮏ㝯ኵⓎ⾲  ❧యつ๎ᛶࡢ㐪࠸࡟ࡼࡿ࣏ࣜ㸦1̺࢖ࢯࣉࣟࣆࣝ࢔ࢡࣜࣝ࢔࣑ࢻ㸧Ỉ⁐ᾮࡢࢤࣝ໬࡜ࢥ
࢖̺ࣝࢢࣟࣅ࣮ࣗࣝ㌿⛣ࡢゎᯒᮾᾏ኱㝔⌮㸪୰㔝ៅஓⓎ⾲ ࢥ࣮ࣛࢤࣥࡢ␗᪉ᛶࢤࣝ໬
໭ᾏ㐨኱Ꮫඛ➃⏕࿨⛉Ꮫ◊✲㝔㸪ྂ⃝࿴ஓⓎ⾲ ࢢࣟࣅ࣮ࣗࣛᅛయࡢ๰〇࡜ᵓ㐀ゎᯒ໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⏕࿨⛉Ꮫ㝔 ⏕࿨⼥ྜ⛉Ꮫࢥ࣮ࢫ㸪ᐩ᳃⏤ె



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&RIIHH%UHDNᚤᑠᚠ⎔ᗙ㛗㸸㕥ᮌὒྖ㸪ᕤ⸨ዡⓎ⾲ ⏕యศᏊ࢖࣓࣮ࢪࣥࢢ࡛᫂ࡽ࠿࡟࡞ࡿ៏ᛶ⅖⑕ࢆ⫼ᬒ࡜ࡍࡿ⏕ά⩦័⑓⑓ែ  ࣓ ࢱ ࣎ࣜࢵࢡࢩࣥࢻ࣮࣒ࣟ࠿ࡽ⾑ᰦᙧᡂ㐣⛬ࡲ࡛̺㸦ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄽᩥ㈹ཷ㈹ㅮ₇㸸 ศ㸧ᮾி኱Ꮫᚠ⎔ჾෆ⛉㸪すᮧᬛⓎ⾲ ⾑₢ᒙࡀ⢓╔ⓑ⾑⌫ࢆྵࡴᚤᑠ⾑⟶ෆὶࢀ࡟ཬࡰࡍᙳ㡪㛵す኱Ꮫ኱Ꮫ㝔㛵す኱Ꮫࢩࢫࢸ࣒⌮ᕤᏛ㒊㸪኱㇂ⱥஅ
Ⓨ⾲ ቨ㏆ഐ࡛ࡢ⢓╔㐣⛬࡟࠾ࡅࡿேᕤ⾑ᑠᯈࡢࢻࣜࣇࢺ࠾ࡼࡧኚື
៞᠕⩏ሿ኱Ꮫ⌮ᕤᏛ㒊㸪㣕ᯇᘯ᫭Ⓨ⾲  ࢞ࢫ㏱㐣ᛶࢆ᭷ࡍࡿ⣽⟶ෆ wP ࢆὶືࡍࡿேᕤ㉥⾑⌫㸦+E ᑠ⬊య㸧ࡢ㓄఩Ꮚ཯ᛂ
᪩✄⏣኱Ꮫ኱Ꮫ㝔ඛ㐍⌮ᕤᏛ㸪ዟ⏣┤ேⓎ⾲ ὶࢀ࡚࠸ࡿ⾑ᾮࡢගᏛ≉ᛶᖇி▷኱㸪㓇ᮏ຾அⓎ⾲ 㧗⢓ᛶ፹య࡟ศᩓࡉࡏࡓ㉥⾑⌫ࡢ⣽⟶ෆ wP ࡟࠾ࡅࡿ≉Ṧ࡞ὶືᵝᘧ:DVHGD%LRVFLHQFH5HVHDUFK,QVWLWXWHLQ6LQJDSRUH᪩✄⏣኱Ꮫ⌮ᕤᏛ◊✲ᡤ㸪㓇஭ᏹỈⓎ⾲ ⾑ᾮಖᏑ࡟࠾ࡅࡿ㉥⾑⌫ࣞ࢜ࣟࢪ࣮ᶵ⬟㞀ᐖ࡜⣚ⶡ⏤᮶ࢧ࣏ࢽࣥࡢຠᯝ
ឡ፾኱࣭་࣭⏕⌮Ꮫ㸪㕥ᮌὒྖ
㦵ࡢࣂ࢖࢜ࣞ࢜ࣟࢪ࣮
ᗙ㛗㸸బࠎᮌ┤ᶞ㸪ྂᕝඞᏊ
Ⓨ⾲ 㦵ศ໬࡟ᑐࡍࡿຊᏛ่⃭ࡢᙳ㡪ࢆㄪ࡭ࡿࡓࡵࡢᇶ㉁ࡢࢫࢡ࣮ࣜࢽࣥࢢ
໭ᾏ㐨኱Ꮫ⏕࿨⛉Ꮫ㝔⏕࿨⼥ྜ⛉Ꮫࢥ࣮ࢫ⤌⧊ᵓ⠏⛉Ꮫ㸪బ⸨⣫ኈᮁⓎ⾲ 㦵ⱆ⣽⬊࡟ࡼࡿ࣐ࢺࣜࢵࢡࢫ▼⅊໬࡟ᑐࡍࡿຊᏛ่⃭ࡢᙳ㡪໭኱㸪ⰼᓮὒᖹ
Ⓨ⾲ 㦵ศ໬࡟ᑐࡍࡿ㊊ሙࡢᵓ㐀ࡢᙳ㡪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔㸪బ⸨⩧୍Ⓨ⾲ 㦵ࡢ⢓ᙎᛶ࡟ཬࡰࡍࢥ࣮ࣛࢤࣥศゎࡢᙳ㡪໭ᾏ㐨኱Ꮫ኱Ꮫ㝔⏕࿨⛉Ꮫ㝔㸪ⓑᕝⱥ㍤⤊஢ࡢ࠶࠸ࡉࡘ



 
 ⥲఍ሗ࿌

≉ᐃ㠀Ⴀ฼άືἲே᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍
ᖹᡂ㸰㸰ᖺᗘ⥲఍ሗ࿌㸦ᖹᡂ㸰㸰ᖺ㸯᭶㸯᪥㹼㸲᭶㸱㸮᪥㸧㇂ୗ ୍ኵ㸨
᪥᫬㸸ᖹᡂ㸰㸰ᖺ㸴᭶㸰᪥㸦Ỉ㸧 㸯㸰㸸㸮㸮㹼㸯㸱㸸㸱㸮ሙᡤ㸸⌮໬Ꮫ◊✲ᡤ࣭㕥ᮌᱵኴ㑻グᛕ࣮࣍ࣝ
఍ဨࡢືྥ㸦ᖹᡂ㸰㸰ᖺ㸯᭶㸯᪥㹼㸰㸰ᖺ㸲᭶㸱㸮᪥㸧   ఍ဨ㸸 㸰㸴㸯ྡ㸦࠺ࡕᏛ⏕఍ဨ㸲㸶ྡ㸧 ධ఍㸯㸮ྡ㸪㏥఍㸯㸯ྡ㸪ᾏእ఍ဨ㸸㸰ྡ   㸦᫖ᖺᗘ㸸఍ဨᩘ 㸰㸵㸵ྡ㸦Ꮫ⏕఍ဨ㸲㸷ྡ㸧㸪ධ఍㸳㸰ྡ㸪㏥఍㸲ྡ㸪ᾏእ఍ဨ㸰ྡ㸧   㸦᫖ᖺࡢࢹ࣮ࢱ࡜▩┪ࡀ࠶ࡿࡀ㸪㏥఍ࡢពᛮࢆ᫂☜࡟ࡉࢀ࡞࠸࡛㸪఍㈝ᮍ⣡ࡢ᪉࡞࡝ࢆ఍ဨ࠿ࡽ
㝖እࡋࡓࡓࡵ㸬㸧   ᙺဨ㸸 ⌮஦㸦࠺ࡕྡ㄃఍ဨ㸧 㸲㸳ྡ㸦㸵ྡ㸧  ┘஦ 㸰ྡ   ㈶ຓ఍ဨ㸸 㸯♫㸯㸬ᖹᡂ  ᖺᗘ๓༙㸦+㹼+㸧஦ᴗሗ࿌㸯㸧➨  ᅇࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ࣜࢧ࣮ࢳࣇ࢛࣮࣒ࣛ㛤ദ㸸+ ៞᠕⩏ሿ኱Ꮫ᪥ྜྷ࢟ࣕࣥࣃࢫ᮶
 ⯋㸦⚄ዉᕝ┴ᶓ὾ᕷ㸧㸰㸧༠㈶࣭ᚋ᥼  ➨  ᅇࣂ࢖࢚࢜ࣥࢪࢽ࢔ࣜࣥࢢㅮ₇఍ +㹼 ᒸᒣ⌮⛉኱Ꮫ㸦ᒸᒣᕷ㸧㸱㸧㟁Ꮚ∧Ꮫ఍ㄅ㸦᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ 㟁Ꮚ∧ % 5 ➨  ᕳ ➨  ྕⓎ⾜㸧㸲㸧-RXUQDORI%LRUKHRORJ\9RO1R
㸳㸧⌮஦఍  ᅇ㛤ദ㸰㸬Ꮫ఍඲యࡢᖹᡂ㸰 ᖺᗘỴ⟬ሗ࿌㸦132 ἲே㸩௵ពᅋయ㸧 㸱᭶㸯㸱᪥࡟㛤ദࡉࢀࡲࡋࡓ⌮஦఍࡟࠾ࡅࡿỴ⟬ሗ࿌ࡣ㸪132 ἲேࡢࡳࡢሗ࿌࡛㸪௵ពᅋయࡢሗ࿌ࡣྵ
ࡲࢀ࡚࠾ࡽࡎ㸪ࡑࡢ⤖ᯝ࡜ࡋ࡚㸪ᴟࡵ࡚ࢃ࠿ࡾ࡟ࡃ࠸ࡈሗ࿌ࢆ⮴ࡋࡲࡋ࡚⏦ࡋヂ࠶ࡾࡲࡏࢇ࡛ࡋࡓ㸬ෆᐜࢆ᫂☜࡟ࡍࡿࡓࡵ࡟㸪Ꮫ఍඲య㸦132 ἲே㸩௵ពᅋయ㸧ࡢỴ⟬ሗ࿌ࢆᨵࡵ࡚ࡉࡏ࡚㡬ࡁࡲࡍ㸬

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㸨

៞ᛂ⩏ሿ኱Ꮫ ⌮ᕤᏛ㒊 ࢩࢫࢸ࣒ࢹࢨ࢖ࣥᕤᏛ⛉ [ࠛ223-8522 ᶓ὾ᕷ ໭༊᪥ྜྷ 3-14-1]᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ㸦㟁Ꮚ∧㸧 ➨  ᕳ ➨  ྕ  ᖹᡂ㻞㻝ᖺᗘỴ⟬ሗ࿌䚷䠄ᖹᡂ㻞㻝ᖺ㻝㻛㻝䡚ᖹᡂ㻞㻝ᖺ㻝㻞㻛㻟㻝䜎䛷䠅཰ධඛᖺᗘ䛛䜙䛾⧞㉺㔠ṇ఍ဨ఍㈝㻞㻝ᖺᗘ௨๓䛾఍㈝㻞㻝ᖺᗘ௨ᚋ䛾఍㈝㈶ຓ఍㈝༠㈶㔠䞉ᐤ௜
ㄽᩥูๅ䜚௦
䠦䠞䠮ᗈ࿌
఍ㄅ኎ୖ
㡸㔠฼Ꮚ
ⴭసᶒᩱ
ྜィ

ᖹᡂ㻞㻝ᖺᗘண⟬ᖹᡂ㻞㻝ᖺᗘỴ⟬ቑῶ㐺⏝㼰㻟㻘㻞㻜㻢㻘㻢㻣㻣㼰㻟㻘㻞㻜㻢㻘㻢㻣㻣㼰㻝㻘㻤㻡㻜㻘㻜㻜㻜㼰㻝㻘㻡㻥㻜㻘㻜㻜㻜㼰㻥㻞㻘㻜㻜㻜 ṇ఍ဨ㽢㻝㻤㻢ྡ䚷䚷Ꮫ⏕఍ဨ㽢㻟㻠ྡ㼰㻟㻟㻢㻘㻜㻜㻜
ṇ఍ဨ㽢㻟㻢ྡ䚷䚷Ꮫ⏕఍ဨ㽢㻝㻢ྡ㼰㻝㻢㻘㻜㻜㻜
ṇ఍ဨ㽢㻞ྡ
㼰㻞㻡㻜㻘㻜㻜㻜
㼰㻡㻜㻘㻜㻜㻜
㼰㻙㻞㻜㻜㻘㻜㻜㻜㼰㻜㼰㻞㻞㻜㻘㻜㻜㻜
㼰㻞㻞㻜㻘㻜㻜㻜㼰㻜㼰㻜㼰㻜㼰㻟㻘㻜㻜㻜㻘㻜㻜㻜㼰㻝㻘㻜㻜㻜㻘㻜㻜㻜 㼰㻙㻞㻘㻜㻜㻜㻘㻜㻜㻜㼰㻜㼰㻞㻘㻜㻜㻜
㼰㻞㻘㻜㻜㻜
㼰㻝㻘㻜㻜㻜
㼰㻝㻘㻢㻡㻞
㼰㻢㻡㻞
㼰㻜
㼰㻠㻣㻝
㼰㻠㻣㻝
㼰㻤㻘㻟㻜㻣㻘㻢㻣㻣㼰㻢㻘㻠㻞㻞㻘㻤㻜㻜 㼰㻙㻝㻘㻤㻤㻠㻘㻤㻣㻣ᨭฟ఍ㄅ༳ๅ㈝䞉㏦ᩱ䛭䛾௚༳ๅ㈝
䛭䛾௚㏦ᩱ
఍ㄅཎ✏ᩱ
஦ົ㈝
㻴㻼సᡂ⟶⌮⥔ᣢ㈝㞧㈝㻶㻮㻾⦅㞟㈝
ᖺ఍⿵ຓ㔠
఍ྜ㈝
Ꮫ఍㈝
㻺㻼㻻ἲே໬⤒㈝
ᅜ⛯
ணഛ㈝
ྜィ
⧞㉺㔠

ᖹᡂ㻞㻝ᖺᗘண⟬ᖹᡂ㻞㻝ᖺᗘỴ⟬ቑῶ㐺⏝㼰㻟㻘㻟㻢㻜㻘㻜㻜㻜㼰㻡㻘㻜㻣㻜㻘㻠㻜㻥 㼰㻙㻝㻘㻣㻝㻜㻘㻠㻜㻥㼰㻠㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻠㻜㻜㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻝㻜㻢㻘㻣㻤㻣
㼰㻙㻢㻘㻣㻤㻣 ษᡭ䚸䛿䛜䛝䚸Ꮿᛴ౽㼰㻜㼰㻜㼰㻜㼰㻣㻞㻜㻘㻜㻜㻜
㼰㻠㻞㻜㻘㻥㻞㻠
㼰㻝㻣㻝㻘㻜㻢㻤 ⤥୚㼰㻝㻤㻥㻘㻜㻜㻜
㼰㻝㻠㻣㻘㻢㻝㻠
㼰㻞㻡㻘㻞㻝㻢 㻴㻼䝯䞁䝔䝘䞁䝇㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻝㻞㻤㻘㻜㻥㻝
㼰㻙㻞㻤㻘㻡㻝㻝 ᑒ⟄䚸䝣䜯䜲䝹䚸䝷䝧䝹䚸㖟⾜᣺㎸㏦㔠ᩱ䚸ᩍᐊ౑⏝ᩱ㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻟㻜㻜㻘㻜㻜㻜
㼰㻞㻜㻢㻘㻣㻢㻡
㼰㻥㻟㻘㻞㻟㻡
㼰㻞㻜㻜㻘㻜㻜㻜
㼰㻟㻞㻟㻘㻤㻠㻜
㼰㻙㻝㻞㻟㻘㻤㻠㻜㼰㻞㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻞㻜㻜㻘㻜㻜㻜
㼰㻟㻜㻜㻘㻜㻜㻜
㼰㻞㻣㻟㻘㻜㻜㻜
㼰㻞㻣㻘㻜㻜㻜
㼰㻜㼰㻡㻞㻘㻠㻝㻢
㼰㻙㻡㻡㻘㻥㻜㻤
㼰㻞㻜㻜㻘㻜㻜㻜
㼰㻞㻞㻘㻤㻢㻝
㼰㻝㻣㻣㻘㻝㻟㻥
㼰㻢㻘㻝㻢㻥㻘㻜㻜㻜㼰㻢㻘㻣㻡㻞㻘㻣㻜㻣㼰㻙㻣㻟㻝㻘㻣㻥㻣㼰㻞㻘㻝㻟㻤㻘㻢㻣㻣㼰㻙㻟㻞㻥㻘㻥㻜㻣ᖹᡂ㻞㻝ᖺᗘ㈚೉ᑐ↷⾲೉᪉⛉┠⌧㔠㒑౽᣺㎸ཱྀᗙ
䝇䝹䜺㖟⾜
ྜィ

㈚᪉
㔠㢠

⛉┠
㼰㻞㻟㻘㻣㻤㻟 ⧞䜚㉺䛧㔠㼰㻝㻘㻤㻤㻟㻘㻜㻜㻜 ᮍᡶ䛔㔠䠆㻝㼰㻥㻞㻣㻘㻜㻠㻠 ๓ཷ䛡㔠䠆㻞ᒸᑠኳᇶ㔠㼰㻞㻘㻤㻟㻟㻘㻤㻞㻣㔠㢠㼰㻙㻟㻞㻥㻘㻥㻜㻣㼰㻜㼰㻜㼰㻟㻘㻝㻢㻟㻘㻣㻟㻠㼰㻞㻘㻤㻟㻟㻘㻤㻞㻣ᒸᑠኳᇶ㔠䚷ᖹᡂ㻞㻝ᖺᗘỴ⟬ሗ࿌䚷䠄ᖹᡂ㻞㻝ᖺ㻝㻛㻝䡚ᖹᡂ㻞㻝ᖺ㻝㻞㻛㻟㻝䜎䛷䠅཰ධඛᖺᗘ䛛䜙䛾⧞㉺㔠฼ᜥྜィᨭฟ㼰㻟㻘㻟㻣㻣㻘㻞㻞㻜 䝯䝎䝹సᡂ㈝㼰㻜 ㏦㔠ᡭᩘᩱ
ィ㼰㻟㻘㻟㻣㻣㻘㻞㻞㻜 ⧞㉺㔠



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

㼰㻞㻝㻞㻘㻤㻡㻢
㼰㻢㻟㻜㼰㻞㻝㻟㻘㻠㻤㻢
㼰㻟㻘㻝㻢㻟㻘㻣㻟㻠 

 

⥲఍ሗ࿌
㸱㸬ᖹᡂ  ᖺᗘ๓༙ࡢỴ⟬ሗ࿌཰ධඛᖺᗘ䛛䜙䛾⧞㉺㔠఍ဨ఍㈝㻞㻝ᖺᗘ௨๓䛾఍㈝㈶ຓ఍㈝༠㈶㔠䞉ᐤ௜
ㄽᩥูๅ䜚௦
௵ពᅋయ䜘䜚ຓᡂ
఍ㄅ኎ୖ
㡸㔠฼Ꮚ
ⴭసᶒᩱ
ᅜ⛯
ྜィ

ᖹᡂ㻞㻞ᖺᗘண⟬ᖹᡂ㻞㻞ᖺᗘỴ⟬㼰㻙㻟㻞㻥㻘㻥㻜㻣㼰㻙㻟㻞㻥㻘㻥㻜㻣㼰㻝㻘㻥㻟㻤㻘㻜㻜㻜㼰㻥㻤㻢㻘㻜㻜㻜
㼰㻜㼰㻝㻝㻟㻘㻜㻜㻜
㼰㻡㻜㻘㻜㻜㻜
㼰㻜
㼰㻜
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㼰㻢㻘㻣㻜㻜㼰㻞㻜㻜㼰㻞㻤㻥㼰㻡㻘㻜㻜㻜
㼰㻠㻘㻞㻜㻜
㼰㻠㻜㻘㻜㻜㻜
㼰㻠㻜㻘㻤㻜㻜
㼰㻝㻘㻣㻜㻟㻘㻞㻥㻟㼰㻤㻞㻝㻘㻜㻤㻞

ቑῶ㼰㻙㻥㻡㻞㻘㻜㻜㻜 ṇ఍ဨ㽢㻝㻞㻝ྡ䚷䚷Ꮫ⏕఍ဨ㽢㻢ྡ㼰㻝㻝㻟㻘㻜㻜㻜 ṇ఍ဨ㽢㻝㻟ྡ䚷䚷Ꮫ⏕఍ဨ㽢㻟ྡ㼰㻙㻡㻜㻘㻜㻜㻜㼰㻜㼰㻜㼰㻜㼰㻢㻘㻣㻜㻜
㼰㻤㻥㼰㻙㻤㻜㻜㼰㻤㻜㻜 㒔⛯㑏௜㔠㼰㻙㻤㻤㻞㻘㻞㻝㻝ᨭฟ఍ㄅ༳ๅ㈝䞉㏦ᩱ䛭䛾௚༳ๅ㈝
䛭䛾௚㏦ᩱ
఍ㄅཎ✏ᩱ
஦ົ㈝
㻴㻼సᡂ⟶⌮⥔ᣢ㈝㞧㈝㻶㻮㻾⦅㞟㈝
ᖺ఍⿵ຓ㔠
఍ྜ㈝
Ꮫ఍㈝
㻺㻼㻻ἲே໬⤒㈝
ᅜ⛯
ணഛ㈝
ྜィ
⧞㉺㔠

ᖹᡂ㻞㻞ᖺᗘண⟬ቑῶᖹᡂ㻞㻞ᖺᗘỴ⟬㼰㻜㼰㻜㼰㻞㻜㻘㻜㻜㻜
㼰㻜㼰㻞㻠㻜㻘㻜㻜㻜
㼰㻠㻜㻘㻜㻜㻜
㼰㻝㻜㻘㻜㻜㻜
㼰㻜㼰㻟㻜㻜㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻡㻜㻘㻜㻜㻜
㼰㻜㼰㻡㻜㻘㻜㻜㻜
㼰㻤㻝㻜㻘㻜㻜㻜
㼰㻤㻥㻟㻘㻞㻥㻟

㐺⏝

㐺⏝
㼰㻜
㼰㻜
㼰㻞㻘㻣㻞㻜 ษᡭ䚸Ꮿᛴ౽㼰㻜㼰㻞㻠㻜㻘㻜㻜㻜 ⤥୚㼰㻠㻜㻘㻜㻜㻜 㻴㻼䝯䞁䝔䝘䞁䝇㼰㻟㻘㻣㻜㻜 㖟⾜᣺㎸㏦㔠ᩱ䚸ᩍᐊ౑⏝ᩱ㼰㻜㼰㻟㻜㻜㻘㻜㻜㻜
㼰㻝㻡㻘㻣㻝㻜
㼰㻜㼰㻡㻜㻘㻜㻜㻜
㼰㻜㼰㻟㻥㻘㻣㻟㻞㼰㻜㼰㻜㼰㻜㼰㻝㻣㻘㻞㻤㻜㼰㻜㼰㻜㼰㻜㼰㻢㻘㻟㻜㻜
㼰㻜㼰㻜㼰㻤㻠㻘㻞㻥㻜㼰㻜㼰㻜㼰㻜㼰㻝㻜㻘㻞㻢㻤
㼰㻝㻝㻤㻘㻝㻟㻤
㼰㻣㻜㻞㻘㻥㻠㻠

ᖹᡂ㻞㻞ᖺᗘ๓༙㈚೉ᑐ↷⾲೉᪉⛉┠⌧㔠㒑౽᣺㎸ཱྀᗙ
䝇䝹䜺㖟⾜
ྜィ

㈚᪉
㔠㢠

⛉┠
㼰㻠㻘㻞㻟㻡 ⧞䜚㉺䛧㔠㼰㻞㻘㻥㻠㻞㻘㻜㻜㻜 ᮍᡶ䛔㔠䠆㻝㼰㻥㻞㻜㻘㻠㻠㻟 ๓ཷ䛡㔠䠆㻞ᒸᑠኳᇶ㔠㼰㻟㻘㻤㻢㻢㻘㻢㻣㻤㔠㢠㼰㻣㻜㻞㻘㻥㻠㻠
㼰㻜㼰㻜㼰㻟㻘㻝㻢㻟㻘㻣㻟㻠㼰㻟㻘㻤㻢㻢㻘㻢㻣㻤ᒸᑠኳᇶ㔠䚷ᖹᡂ㻞㻞ᖺᗘỴ⟬ሗ࿌䚷䠄ᖹᡂ㻞㻞ᖺ㻝㻛㻝䡚ᖹᡂ㻞㻞ᖺ㻠㻛㻟㻜䜎䛷䠅཰ධඛᖺᗘ䛛䜙䛾⧞㉺㔠฼ᜥྜィᨭฟ㼰㻟㻘㻝㻢㻟㻘㻣㻟㻠 䝯䝎䝹సᡂ㈝㼰㻜 ㏦㔠ᡭᩘᩱ
ィ㼰㻟㻘㻝㻢㻟㻘㻣㻟㻠 ⧞㉺㔠






㼰㻜
㼰㻜
㼰㻜
㼰㻟㻘㻝㻢㻟㻘㻣㻟㻠 ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ㸦㟁Ꮚ∧㸧 ➨  ᕳ ➨  ྕ  㸲㸬ᖹᡂ㸰㸰ᖺᗘ஦ᴗィ⏬㸦+㹼+㸧㸯㸧➨  ᅇᖺ఍ࡢ㛤ദ㸸+⌮໬Ꮫ◊✲ᡤ㸦࿴ගᕷ㸧㸰㸧➨  ᅇᅜ㝿ࢩ࣏ࣥࢪ࣒࢘ࡢ㛤ദ㸸+ ⌮໬Ꮫ◊✲ᡤ㸦࿴ගᕷ㸧㸱㸧㟁Ꮚ∧Ꮫ఍ㄅ㸦᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ % 5 㟁Ꮚ∧ ➨  ᕳ  ྕ㸲㸧Ꮫ఍ㄅ ᖺ఍ᢒ㘓ྕࡢⓎ⾜㸳㸧ⱥᩥㄅ -RXUQDORI%LRUKHRORJ\ 9RO1R 㸴㸧ඹദ
࣭WK3DFLILF5LP&RQIHUHQFHRQ5KHRORJ\㸦᪥ᮏࣞ࢜ࣟࢪ࣮Ꮫ఍㸪᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ
఍ඹྠ୺ദ㸧 +㹼㸪໭ᾏ㐨኱Ꮫ㸦ᮐᖠᕷ㸧࣭➨  ᅇࣞ࢜ࣟࢪ࣮ウㄽ఍㸦᪥ᮏࣞ࢜ࣟࢪ࣮Ꮫ఍࣭᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍୺ദ㸧+
㹼 ௝ྎᅜ㝿ࢭࣥࢱ࣮㸦௝ྎᕷ㸧࣭➨  ᅇࣞ࢜ࣟࢪ࣮ࣇ࢛࣮࣒ࣛ㸦᪥ᮏࣞ࢜ࣟࢪ࣮Ꮫ఍࣭᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍୺ദ㸧+㹼 ௝ྎᅜ㝿ࢭࣥࢱ࣮㸦௝ྎᕷ㸧㸵㸧༠㈶࣭ᚋ᥼࣭➨  ᅇࣂ࢖࢚࢜ࣥࢪࢽ࢔ࣜࣥࢢㅮ₇఍ +㹼 ⇃ᮏ኱Ꮫ㯮㧥࢟ࣕࣥࣃࢫ࣭➨  ᅇΰ┦ὶࢩ࣏ࣥࢪ࣒࢘ +㹼㟼ᒸ኱Ꮫ㸦὾ᯇᕷ㸧㸶㸧⌮஦఍㸸 ᅇ㛤ദணᐃ㸪-%5 ⦅㞟ጤဨ఍  ᅇ㛤ദணᐃ㸷㸧ࡑࡢ௚
㸳㸬ᖹᡂ㸰㸰ᖺᗘ๓༙ண⟬᱌ᖹᡂ㻞㻞ᖺᗘ๓༙䠄㻞㻞㻚㻝㻚㻝䛛䜙㻞㻞㻚㻠㻚㻟㻜䜎䛷䠅཰ධඛᖺᗘ䛛䜙䛾⧞㉺㔠
ṇ఍ဨ఍㈝
㈶ຓ఍㈝
༠㈶㔠䞉ᐤ௜
ㄽᩥูๅ䜚௦
௵ពᅋయ䛛䜙䛾ຓᡂ
఍ㄅ኎ୖ
㡸㔠฼Ꮚ
䛭䛾௚
ྜ䚷ィ

ᨭฟ
఍ㄅ༳ๅ㈝䞉Ⓨ㏦ᩱ䛭䛾௚༳ๅ㈝
䛭䛾௚㏦ᩱ
఍ㄅཎ✏ᩱ
஦ົ㈝
㻴㻼సᡂ⟶⌮⥔ᣢᩱ㞧㈝㻶㻮㻾⦅㞟㈝
ᖺ఍⿵ຓ㔠
఍ྜ㈝
Ꮫ఍㈹
㻺㻼㻻ἲே໬⤒㈝
ணഛ㈝
ᨭฟྜィ
⧞㉺㔠

䚷䚷䚷䚷䚷䚷䚷䚷༢఩䠖෇ᖹᡂ㻞㻞ᖺᗘண⟬㐺⏝㼰㻙㻟㻞㻥㻘㻥㻜㻣㼰㻝㻘㻥㻟㻤㻘㻜㻜㻜 ṇ఍ဨ㻞㻟㻥ྡ䚸Ꮫ⏕㻠㻥ྡ㼰㻡㻜㻘㻜㻜㻜 㻡㻜㻘㻜㻜㻜෇㽢䠍ཱྀ
㼰㻜
㼰㻜
㼰㻜
㼰㻜
㼰㻞㻜㻜
㻠㻡㻜㻜㻜
㼰㻝㻘㻣㻜㻟㻘㻞㻥㻟ᖹᡂ㻞㻞ᖺᗘண⟬䚷䚷䚷䚷䚷䚷䚷䚷༢఩䠖෇
㐺⏝

㼰㻜
㼰㻜
ᢒ㘓㞟༳ๅ䛺䛹
㼰㻞㻜㻘㻜㻜㻜
஦ົ㐃⤡㼰㻜㼰㻞㻠㻜㻘㻜㻜㻜 㻢㻜㻘㻜㻜㻜㻛᭶㼰㻠㻜㻘㻜㻜㻜
㼰㻝㻜㻘㻜㻜㻜
㼰㻜㼰㻟㻜㻜㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻡㻜㻘㻜㻜㻜
㼰㻡㻜㻘㻜㻜㻜
㼰㻤㻝㻜㻘㻜㻜㻜
㼰㻤㻥㻟㻘㻞㻥㻟





 

⥲఍ሗ࿌
㸴㸬 ᖺᗘண⟬᱌㸦++㸧ᖹᡂ㻞㻞ᖺᗘ䠄㻞㻞㻚㻡㻚㻝䛛䜙㻞㻟㻚㻠㻚㻟㻜䜎䛷䠅཰ධඛᖺᗘ䛛䜙䛾⧞㉺㔠
ṇ఍ဨ఍㈝
㈶ຓ఍㈝
ᗈ࿌
ㄽᩥูๅ䜚௦
ᐤ௜
఍ㄅ኎ୖ
㡸㔠฼Ꮚ
䛭䛾௚
ྜ䚷ィ

䚷䚷䚷䚷䚷䚷䚷䚷༢఩䠖෇ᖹᡂ㻞㻞ᖺᗘண⟬㐺⏝㼰㻣㻜㻞㻘㻥㻠㻠
㼰㻥㻡㻞㻘㻜㻜㻜 㻞㻞ᖺᗘᮍ཰ศ
㼰㻡㻜㻘㻜㻜㻜 㻡㻜㻘㻜㻜㻜෇㽢䠍ཱྀ㼰㻟㻘㻜㻜㻜㻘㻜㻜㻜㼰㻜㼰㻞㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻝㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻡㻘㻜㻜㻡㻘㻥㻠㻠ᨭฟ఍ㄅ༳ๅ㈝䞉Ⓨ㏦ᩱ䛭䛾௚༳ๅ㈝
䛭䛾௚㏦ᩱ
఍ㄅཎ✏ᩱ
஦ົ㈝
㻴㻼సᡂ⟶⌮⥔ᣢᩱ㞧㈝㻶㻮㻾⦅㞟㈝
ᖺ఍⿵ຓ㔠
఍ྜ㈝
Ꮫ఍㈹
㻺㻼㻻ἲே໬⤒㈝
ணഛ㈝
ᨭฟྜィ
⧞㉺㔠

䚷䚷䚷䚷䚷䚷䚷䚷༢఩䠖෇ᖹᡂ㻞㻞ᖺᗘண⟬㐺⏝㼰㻟㻘㻟㻢㻜㻘㻜㻜㻜㼰㻜ᢒ㘓㞟༳ๅ䛺䛹
㼰㻝㻜㻜㻘㻜㻜㻜
஦ົ㐃⤡㼰㻜㼰㻣㻞㻜㻘㻜㻜㻜 㻢㻜㻘㻜㻜㻜㻛᭶㼰㻝㻞㻜㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻞㻜㻜㻘㻜㻜㻜
㼰㻜㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻝㻜㻜㻘㻜㻜㻜
㼰㻠㻘㻥㻜㻜㻘㻜㻜㻜㼰㻝㻜㻡㻘㻥㻠㻠
㸵㸬༠㆟஦㡯㸯㸧఍㛗ࡢ㑅ฟ㸸㇂ୗ୍ኵ⌧఍㛗㸦៞᠕⩏ሿ኱Ꮫ㸧ࢆᘬࡁ⥆ࡁ఍㛗࡟㑅ฟࡋࡓ㸬㸰㸧᪂ᙺဨࡢ㑅ฟ㸸ྡ㄃㢳ၥ㸪⌮஦㸪┘஦㸪ホ㆟ဨ ྡ㄃㢳ၥ  ྡ㸦㡰୙ື㸪ᩗ⛠␎㸧ὸ㔝∾ⱱ㸦ᅜ❧ಖ೺་⒪⛉Ꮫ㝔㸧ụᮏ༟㸦ᮾிឿᜨ་኱㸧☾㈅⾜⚽㸦⾰➟⑓㝔㸧኱ஂಖ༓௦ḟ㸦㟁☢⏺᝟ሗࢭࣥࢱ࣮㸧኱ᓥᐉ㞝㸦⟃Ἴ኱Ꮫ㸧ᑠᒣᐩᗣ㸦໭ᾏ㐨኱Ꮫ㸧㈅ཎᏛ㸦ᖇி኱Ꮫ㸧⚄㇂░㸦᪥ᮏ኱Ꮫ㸧ᆏす᫂㑻㸦⩌㤿኱Ꮫ㸧Ⳣཎᇶ᫭㸦ጲ㊰⋊༠኱Ꮫ㸧᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ㸦㟁Ꮚ∧㸧 ➨  ᕳ ➨  ྕ すᡂ຾ዲ㸦኱㜰ᕷ❧኱Ꮫ㸧ᮏᕝ㐩㞝㸦ᮾிᕤᴗ኱Ꮫ㸧๓⏣ಙ෬㸦ឡ፾኱Ꮫ㸧ᓠୗ㞝㸦ᖇሯᒣ኱Ꮫ㸧ᶓ℩⌶⏨㸦ᮾிឿᜨ་኱㸧Ლ㇂ᩥᙪ㸦ᕝᓮ་⒪⚟♴኱Ꮫ㸧ᮧ⏣ᛅ⩏㸦ᮾி㒔❧኱Ꮫ㸧బ⸨ṇ᫂㸦ᮾ໭኱Ꮫ㸧   ⌮஦ 㸵ྡ㸦⌮஦ࡢඛ⏕ࡣ㸪ホ㆟ဨ࡛ࡶ࠶ࡾࡲࡍ㸬㸧ᅵᶫᩄ᫂㸦⩌㤿኱Ꮫ㸧ෆᮧຌ㸦ᮾி་⛉ṑ⛉኱Ꮫ㸧Ᏻ⸨ㆡ஧㸦⋊༠་⛉኱Ꮫ㸧Ặᐙᘯ㸦ᮾிປ⅏⑓㝔㸧㈅ཎ┿㸦⌮໬Ꮫ◊✲ᡤ㸧ᚋ⸨ಙဢ㸦ᮾᾏ኱Ꮫ㸧బࠎᮌ┤ᶞ㸦໭ᾏ㐨኱Ꮫ㸧బ⸨ᜨ⨾Ꮚ㸦᪂₲┴❧኱Ꮫ㸧㛵┾బᏊ㸦㛵す኱Ꮫ㸧୍ᮡṇோ㸦⋊༠་⛉኱Ꮫ㸧୸ᒣᚭ㸦஑ᕞ኱Ꮫ㸧ᮃ᭶⢭୍㸦ᕝᓮ་⒪⚟♴኱Ꮫ㸧ᒣᮏᕼ⨾Ꮚ㸦ᮾி኱Ꮫ㸧ྜྷ⏣㞞ᖾ㸦ᮾி་⛉ṑ⛉኱Ꮫ㸧㇂ୗ୍ኵ㸦៞᠕⩏ሿ኱Ꮫ㸧ᕤ⸨ዡ㸦Ⱚᾆᕤᴗ኱Ꮫ㸧኱ᶫಇᮁ㸦໭ᾏ㐨኱Ꮫ㸧   ┘஦  ྡ㓇ᮏ຾அ㸦ᖇி▷኱㸧ྜྷᮧ⨾⣖㸦රᗜ┴❧኱㸧   ホ㆟ဨ  ྡ㛗㇂㒊ගἨ㸦ᮾ㑥኱Ꮫ་Ꮫ㒊㸧ᒣᮏᚨ๎㸦ྡྂᒇ኱Ꮫ་Ꮫ㒊㸧༡ᒣồ㸦ᗈᓥᅜ㝿኱Ꮫ㸧ᒣ⏣ᏹ㸦஑ᕞᕤᴗ኱Ꮫ㸧ᮾ⸨ṇᾈ㸦໭ᾏ㐨኱Ꮫ㸧ᒾᓮΎ㝯㸦᪩✄⏣኱Ꮫ㸧



 

⥲఍ሗ࿌

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⸨஭ಟ἞㸦㛗ᒸᢏ⾡⛉Ꮫ኱Ꮫ㸧႐ከ⌮⋤㸦ᮾᾏ኱Ꮫ⌮Ꮫ㒊㸧እᒣྜྷ἞㸦⩌㤿኱Ꮫ㸧ᕷᕝᑑ㸦㛗ᓮ኱Ꮫ㸧㔠⏣ຬ㸦㓗㎰Ꮫᅬ኱Ꮫ㸧㧗ᶫᬛᏊ㸦⚄ዉᕝᕤ⛉኱Ꮫ㸧▼ᶫᩄᐶ㸦ᮾிឿᜨ་⛉኱Ꮫ㸧ᵐ㟹ᖾ㸦⩌㤿኱Ꮫ㸧す⏣ṇᾈ㸦⏘⥲◊㸧ᖹᑿ࿴Ꮚ㸦ឡᅜᏛᅬ▷኱㸧኱ᓥࡲࡾ㸦ᮾி኱Ꮫ㸧㸱㸧ᐃḰ᪋⾜⣽๎࡟క࠺஦ົᒁࡢ⛣㌿㸸ᅵᶫ๪఍㛗ࡢ⩌㤿኱Ꮫ࡟⛣㌿ࡍࡿ஦࡜ࡋࡓ㸬
㸲㸧-%5 ⦅㞟㛗ࡢ㑅ฟ㸸బࠎᮌ┤ᶞඛ⏕࠿ࡽ㇂ୗ୍ኵ࡟஺௦ࡋࡓ㸬㸳㸧ྛጤဨ఍ࡢጤဨ㛗ࡢ㑅ฟ㟁Ꮚ∧ % 5 ⦅㞟ጤဨ㛗㸸ᮃ᭶⢭୍ඛ⏕㸦ᕝᓮ་⒪⚟♴኱Ꮫ㸧ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ࣜࢧ࣮ࢳࣇ࢛࣮࣒ࣛ㐠Ⴀጤဨ఍ጤဨ㛗㸸ᒣᮏᕼ⨾Ꮚඛ⏕㸦ᮾி኱Ꮫ㸧㸴㸧ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮௻⏬ጤဨ఍ࡢタ⨨Ꮫ఍࠿ࡽࡢඛ㐍ⓗ࡞Ꮫ⾡ⓎಙࢆάⓎ࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡟ࡋ࡚㸪௨ୗࡢࡼ࠺࡞௻⏬ጤဨ఍ࡢタ⨨ࡀ㇂ୗ఍㛗࠿ࡽᥦ᱌ࡉࢀ㸪ࡉࡽ࡟ᙺဨࡸ఍ဨࡢ᪉ࠎ࠿ࡽࡈពぢࢆ㡬ࡁ࡞ࡀࡽ௻⏬ጤဨ఍ࡢάື
ෆᐜࢆ᳨ウࡍࡿࡇ࡜࡜ࡋࡓ㸬㸦௨ୗࡣᐃḰ᪋⾜⣽๎୰ࡢつ⣙᱌࡛࠶ࡿ㸬㸧➨㸵❶㸦ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮௻⏬ጤဨ఍㸧➨ 1 ᮲ ᮏጤဨ఍ࢆ≉ᐃ㠀Ⴀ฼άືἲே᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮௻⏬ጤဨ఍㸦௨ୗ㸪௻⏬ጤဨ఍࡜␎グ㸧࡜⛠ࡍࡿ㸬
➨ 2 ᮲ ௻⏬ጤဨ఍ࡢ┠ⓗࡣ≉ᐃ㠀Ⴀ฼άືἲே᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࡢᖺ఍㸪JBR ࠾ࡼࡧ㟁
Ꮚ∧ B&R ࡢࢸ࣮࣐ࢆ⥅⥆ⓗ࡟௻⏬ࡍࡿࡇ࡜࡛࠶ࡿ㸬༶ࡕ㸪ᖺ఍࡟࠾ࡅࡿᣍᚅㅮ₇㸪ࢩ࣏ࣥࢪ࣒࢘㸪࣮࢜࢞ࢼ࢖ࢬࢻࢭࢵࢩࣙࣥ㸪JBR ࠾ࡼࡧ㟁Ꮚ∧ B&R ࡢグ஦ࡢ౫㢗ཎ✏࡞࡝࡟㛵ࡍࡿ௻⏬ࢆ⾜࠸㸪ᖺ఍㛗㸪JBR ⦅㞟ጤဨ㛗㸪㟁Ꮚ∧ B&R ⦅㞟ጤဨ㛗࡟ᥦ᱌ࡍࡿ㸬➨ 3 ᮲ ௻⏬ጤဨ఍ࡣḟࡢ࣓ࣥࣂ࣮࠿ࡽᵓᡂࡉࢀࡿ㸬௻⏬ጤဨ㛗㸪ᑠጤဨ఍୺ᰝ 6 ྡ㸪ྛᑠጤဨ఍ጤဨⱝᖸྡ
➨ 4 ᮲ ᑠጤဨ఍ࡣ㸪௨ୗࡢ㸴ศ㔝࡜ࡍࡿ㸬㸯㸬⾑⟶ෆ་἞⒪㸰㸬ᚠ⎔ჾ⣔ࢲ࢖ࢼ࣑ࢡࢫ࡜⑌ᝈ
㸱㸬⣽⬊࣭ศᏊࡢ࣓࢝ࣀࣂ࢖࢜ࣟࢪ࣮
㸲㸬ࢸ࢖ࢵࢩ࢚ࣗࣥࢪࢽ࢔ࣜࣥࢢ
㸳㸬⏕య≀㉁ࡢᵓ㐀ᙧᡂ࡜ᶵ⬟Ⓨ⌧࣭ไᚚ㸴㸬࣊ࣝࢫࢣ࢔㣗ရ⛉Ꮫ
➨ 5 ᮲ ௻⏬ጤဨ㛗ࡣᮏᏛ఍⌮஦ࡢ୰࠿ࡽ㑅ฟࡋ㸪⌮஦఍㸪⥲఍ࡢᢎㄆࢆ⤒࡚⌮஦㛗ࡀጤკࡍࡿ㸬᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ㄅ㸦㟁Ꮚ∧㸧 ➨  ᕳ ➨  ྕ  

௵ᮇࡣ 2 ᖺ࡜ࡍࡿ㸬෌௵ࡣጉࡆ࡞࠸㸬➨ 6 ᮲ ᑠጤဨ఍୺ᰝࡣ఍ဨࡢ୰࠿ࡽ௻⏬ጤဨ㛗ࡀᣦྡࡋ㸪⌮஦㛗ࡀጤკࡍࡿ㸬௵ᮇࡣ 2 ᖺ࡜ࡍࡿ㸬෌௵ࡣጉࡆ࡞࠸㸬ᑠጤဨ఍ጤဨࡣ㸪఍ဨࡢ୰࠿ࡽᑠጤဨ఍୺ᰝࡀᣦྡࡋ㸪⌮஦㛗ࡀጤკࡍࡿ㸬௵ᮇ
ࡣ 2 ᖺ࡜ࡍࡿ㸬෌௵ࡣጉࡆ࡞࠸㸬㸵㸧ḟᅇ㸦ᖹᡂ  ᖺᗘ㸧㸪ḟࠎ఍㸦ᖹᡂ  ᖺᗘ㸧ࡢᖺ఍㛤ദ࡟㛵ࡍࡿ௳ḟᅇ㸦ᖹᡂ  ᖺᗘ㸧ࡢ➨  ᅇᖺ఍ࡣ㸪ᖹᡂ  ᖺ  ࡟㛵┾బᏊඛ⏕㸦㛵す኱Ꮫ㸧ࢆᖺ఍㛗࡜ࡋ࡚‽ഛࡀ㐍ࢇ࡛࠸ࡿ㸬ࡲࡓ㸪ḟࠎᅇᖺ఍㸦ᖹᡂ  ᖺᗘ㸧ࡢᖺ఍㛗ࡣ༠㆟୰࡛࠶ࡿ㸬㸶㸧ࡑࡢ௚
㸶㸬ሗ࿌஦㡯㸸≉࡟↓ࡋ㸷㸬ࡑࡢ௚㸸≉࡟↓ࡋ

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 ➨ 6 ᅇ ୡ ⏺ 䝞 䜲 䜸 䝯 䜹 䝙 䜽 䝇 ఍ ㆟ 䠄 6th World
Congress of Biomechanics䠈௨ୗ WCB䠅䛜 2010 ᖺ 8
᭶ 1 ᪥䛛䜙 6 ᪥䜎䛷䝅䞁䜺䝫䞊䝹䛾 Singapore Suntec
Convention Centre 䛻䛚䛔䛶㛤ദ䛥䜜䛯䠊ᮏ఍㆟䛿
14th International Conference on Biomedical
Engineering (ICBME) 䛚 䜘 䜃 5th Asian PacificConference on Biomechanics (AP Biomech)䛸ඹദ䛧䛶㛤ദ䛥䜜䛯䠊ୡ⏺ྛᅜ䛛䜙 2000 ྡ௨ୖ䛾ཧຍ⪅䛜䛒䜚䠈15 ௳䛾䝥䝺䝘䝸䞊䝺䜽䝏䝱䞊䠄1 ᪥ 3 ௳䠅䠈⣙
1400 ௳䛾ཱྀ㢌Ⓨ⾲䠈⣙ 600 ௳䛾䝫䝇䝍䞊Ⓨ⾲䛜⾜䜟䜜䛯䠊䜎䛯 33 䛾ᒎ♧䝤䞊䝇䛜タ䛡䜙䜜䠈᪥ᮏ䛛䜙䛾ཧຍ⪅䜒ከ䛟ぢ䜙䜜䛯䠊㻌 ㉥㐨┤ୗ䛾༡ᅜ䛷䛾䝅䞁䜺䝫䞊䝹䛷䛾㛤ദ䛷䛒䛳䛯䛜䠈௒ᖺ䛿᪥ᮏ䛜㠀ᖖ䛻ᬬ䛔ኟ䛷䛒䛳䛯䛯䜑䠈䝅䞁䜺䝫䞊䝹䛾᪉䛜ᛌ㐺䛻㐣䛤䛩䛣䛸䛜ฟ᮶䛯䠊䛺䛚䠈䝅䞁䜺䝫䞊䝹䛷䛿እẼ 䛿ᖖ䛻 30䉝๓ᚋ䛷䛒䜛䛜䠈ᘓ≀䛾୰䛷䛿✵ㄪ䛜ᖖ䛻㐣๫䛻ຠ䛔䛶䛔䜛䛯䜑እẼ 䛸䛾ᕪ䛜኱䛝䛟䠈䛺䛬䛛㠀ᖖ䛻ᐮ䛔⎔ቃ䛻᭚䛥䜜䜛䠊䛭䛾䛯䜑䠈䝅䞁䜺䝫䞊䝹䛷䛾Ꮫ఍䛻ཧຍ䛩䜛㝿䛻䛿⚾䛿ᖖ䛻㛗⿇䛾ୖ╔䜢ᣢཧ䛩䜛䜘䛖䛻䛧䛶䛔䜛䠊䝅䞁䜺䝫䞊䝹䛻ึ䜑䛶ゼၥ䛩䜛᪉䛜䛔䜙䛳䛧䜓䜛ሙྜ䛻䛿᫝㠀ୖ╔䜢ᣢ䛳䛶䛔䛟䛣䛸䜢䛚ዡ䜑䛩䜛䠊㻌 ⚾䛻䛸䛳䛶ึ䜑䛶䛾 WCB 䜈䛾ཧຍ䛷䛒䜚䠈ᙜึ○䛡䛯㞺ᅖẼ䜢᝿ീ䛧䛶䛔䛯䛜䠈ᐇ㝿䛻䛿 8 ᫬ 30 ศ䛛䜙 19 ᫬䜎䛷㠀ᖖ䛻䝍䜲䝖䛺䝇䜿䝆䝳䞊䝹䛾఍㆟䛷䛒䜚䠈⇕Ẽ䛾䛒䜛㞺ᅖẼ䛻㦫䛛䛥䜜䛯䠊኱䛝䛟 6 䛴䛾䝔䞊䝬䠄 Theme 1: Special Topics 䠈 Theme 2: Organ
Mechanics, Theme 3: Tissue Mechanics, Theme 4:
Cell Mechanics, Theme 5: Molecular Mechanics,
Theme 6: Materials, Tools, Devices and Techniques䠅䛻ศ䛛䜜䠈ከ䛔䛸䛝䛻䛿ྠ䛨᫬㛫ᖏ䛻 17 ఍ሙ䛷䝉䝑䝅䝵䞁䛜㛤ദ䛥䜜䛶䛔䛯䛯䜑䠈ཧຍ䛩䜛䝉䝑䝅䝵䞁䜢ཝ㑅䛩䜛ᚲせ䛜䛒䛳䛯䠊䛧䛛䛧䠈ⴭྡ䛺ᩍᤵ䛛䜙ⱝᡭ◊✲⪅䛾Ⓨ⾲䜎䛷ᖜᗈ䛔ୡ௦䛾Ⓨ⾲⪅䛾ㅮ₇䜢⫈䛟䛣䛸䛜䛷䛝䠈䜎䛯 1 䛴䛾Ⓨ⾲୰䛻ㄽᩥᩘᮏศ䛾ෆᐜ䜢จ⦰䛧䛯ᐦᗘ䛾⃰䛔Ⓨ⾲䜒ᩘከ䛟ぢ䜙䜜䠈㠀ᖖ䛻่⃭ⓗ䛷඘ᐇឤ䛾䛒䜛఍㆟䛷䛒䛳䛯䠊㻌 ⚾䛿୺䛻 Cell Mechanics 䜢୰ᚰ䛸䛧䛯䝉䝑䝅䝵䞁䛻ཧຍ䛧䛯䠊䛭䛾୰䛷䠈䝞䜲䜸䝺䜸䝻䝆䞊䜢୺㢟䛸䛧䛯䝅䞁䝫䝆䜴䝮䛷䛒䜛”Recent Trends in Biorheology
and Microcirculation”䛾Ⓨ⾲䛾䜏䛺䜙䛪䠈䛭䛾௚䛾䝉䝑䝅䝵䞁䛻䛚䛡䜛Ⓨ⾲䛷䜒䠈⤌⧊䠈⣽⬊䠈ศᏊ䝺䝧䝹䛷䛾ᣲື䛾䝰䝕䝹໬䛻㛵䛩䜛◊✲䛾ከ䛔䛣䛸䜢ឤ䛨䜙䜜䛯䠊䝰䝕䝹໬䛻䛚䛔䛶䠈࿘ᅖ䛾ຊᏛ⎔ቃ䛚䜘䜃⤌⧊䠈⣽⬊䜔ศᏊ⮬㌟䛾䝺䜸䝻䝆䞊≉ᛶ䜢ᐃ㔞ⓗ䛻ᢕᥱ䛩䜛䛣䛸䛜ᚲせ䛸䛺䜚䠈⤌⧊䠈⣽⬊䠈ศᏊ䛾䝺䜸䝻䝆䞊≉ᛶ䛻㛵䛩䜛◊✲䜒ከ䛟ぢ䜙䜜䛯䠊ᮏ䝞䜲䜸䝺䜸䝻䝆䞊Ꮫ఍䛻䛚䛔䛶⾜䜟䜜䛶䛔䜛䛣䜜䜙䛾◊✲䛾㔜せᛶ䛜௒ᚋ䛥䜙䛻ὀ┠䛥䜜䜛䛣䛸䛜ᮇᚅ䛥䜜䜛䠊㻌 䛣䛾఍㆟䛿 4 ᖺ䛻 1 ᗘ⾜䜟䜜䠈ḟᅇ➨7 ᅇ఍㆟䛿 2014ᖺ䛾䜰䝯䝸䜹䛾䝪䝇䝖䞁䛷⾜䜟䜜䜛ணᐃ䛷䛒䜛䠊෗┿䠍䠖䝫䝇䝍䞊䝉䝑䝅䝵䞁䛾ᵝᏊ䠊ẖ᪥᭱ᚋ䛾᫬㛫ᖏ䛻䜒ᣊ䜟䜙䛪άⓎ䛺㆟ㄽ䛜⾜䜟䜜䛶䛔䛯䠊෗┿㸰㸸ࣂࣥࢣࢵࢺࡢᵝᏊ㸬ࢭࣥࢺ࣮ࢧᓥ࡛⾜ࢃࢀ㸪ࢫࢸ࣮ࢪ࡛ࡣ⌧ᆅࡢ㋀ࡾ࡞࡝ࡀᢨ㟢ࡉࢀࡓ㸬

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 
 ᑂᰝሗ࿌

ᒸᑠኳ㈹ᑂᰝሗ࿌
➨㸵ᅇᒸᑠኳ㈹
㑅⪃ጤဨ఍ጤဨ㛗 ᅵᶫ ᩄ᫂㸨 ᒸᑠኳ㈹ࡣࠊࣂ࢖࢜ࣞ࢜ࣟࢪ࣮࡟㛵ࡍࡿᏛ⾡࠶ࡿ࠸ࡣ㛵㐃ࡢ஦ᴗ࡟ᑐࡋ≉ู࡞ຌ⦼ࡀ࠶ࡾࠊࡑࡢຌ⦼ࡀ㢧ⴭ࡛
࠶ࡿ᪉࡟㉗ࡽࢀࡿ㈹࡛࠶ࡾࠊ᫖ᖺᗘࡲ࡛㸴ᅇࡢ㑅⪃ࡀ⾜࡞ࢃࢀ࡚࠾ࡾࡲࡍࠋཷ㈹⪅ࡣ࠸ࡎࢀࡶ᪥ᮏࡢࣂ࢖࢜ࣞ࢜
ࣟࢪ࣮◊✲ศ㔝ࢆ㛤ᣅࡋ࡚ࡁࡓⲡศࡅⓗ࡞Ꮡᅾ࡛࠶ࡾឤ㖭ࢆཷࡅࡲࡍࠋ
➨㸵ᅇ㑅⪃࡛ࡣࠊ᫖ᖺ㸯㸮᭶࠿ࡽ㸯㸰᭶ࡲ࡛᥎⸀ࢆཷࡅ௜ࡅࠊ⥾ࡵษࡾࡲ࡛࡟㸯ྡࡢ᥎⸀ࢆ࠸ࡓࡔࡁࡲࡋࡓࠋ
㑅⪃ࡣࠊ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ᒸᑠኳ㈹㑅⪃つ⛬࡟ᚑࡗ࡚ࠊ㸯㸮ྡࡢᑂᰝጤဨ఍ࢆ⤌⧊ࡋࠊៅ㔜࡞ᑂ㆟࡟ࡼࡾ⾜ࢃࢀࡲࡋࡓࠋࡑࡢ⤖ᯝࠊ⿕᥎⸀⪅࡛࠶ࡿⳢཎᇶ᫭Ặࡀᒸᑠኳ㈹࡟┦ᛂࡋ࠸࡜ࡢ⤖ㄽ࡟⮳ࡾࡲࡋࡓࠋᑂᰝ⤖ᯝࡣ㑅⪃ጤဨ㛗࠿ࡽᏛ఍㛗࡟ሗ࿌ࡉࢀࡓᚋࠊ⌮஦఍࡟ᥦ᱌ࡉࢀࠊᢎㄆࡉࢀࡲࡋࡓࠋ
Ⳣཎᇶ᫭ẶࡣᮾிዪᏊ་⛉኱Ꮫ࠾ࡼࡧጲ㊰⋊༠኱Ꮫࡢᩍᤵ࡜ࡋ࡚ᩍ⫱◊✲࡟ᦠࢃࡾࠊከࡃࡢேᮦࢆ⫱ᡂࡉࢀࡲࡋࡓࠋ◊✲㠃࡟࠾࠸࡚ࡣࠊᚠ⎔ჾ㡿ᇦࡢὶయຊᏛⓗ◊✲ࡢⓎᒎ࡟㛗ᖺ㈉⊩ࡋࠊᚠ⎔ჾ⑓ኚࡢ⑓
ែࡢ⌮ゎࢆ῝ࡵࠊ࠿ࡘ་Ꮫ࡜⌮ᕤᏛ࡜ࡢඹྠ◊✲ࢆ㐍ࡵࡽࢀࡲࡋࡓࠋ≉࡟ࠊ㉸㡢Ἴィ࡟࠾࠸࡚ࠊ⬦Ἴఏᦙ㏿ᗘ࡞࡝ࡢࡈ◊✲࡛኱ኚ⣲ᬕࡽࡋ࠸ᡂᯝࢆ࠶ࡆ࡚࠾ࡽࢀࡲࡍࠋࡑࢀࡽࡢᴗ⦼ࡣከࡃࡢཎⴭㄽᩥࠊⴭ
᭩ࠊ≉チ➼࡟Ⓨ⾲ࡉࢀࠊᅜ㝿ⓗ࡟ࡶ㧗ࡃホ౯ࡉࢀ࡚࠸ࡲࡍࠋࡲࡓࠊᚠ⎔ჾ⣔ࡢⱥᩥㄅ”Heart & Vessels”
ࡢ❧ࡕୖࡆ࠿ࡽ⦅㞟ࡲ࡛ᡭࡀࡅࡽࢀࡓຌ⦼࡟ࡣከ኱࡞ࡶࡢࡀ࠶ࡾࡲࡍࠋ
᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍࡛ࡣࠊ๰❧௨᮶ࠊᏛ఍⌮஦࡜ࡋ࡚Ꮫ఍ࡢ㐠Ⴀࡢࡓࡵ࡟✚ᴟⓗ࡟ྲྀࡾ⤌ࡲࢀࠊ᪥ᮏ࡟࠾ࡅࡿࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ࡢᬑཬ࣭Ⓨᒎ࡟㈉⊩ࡉࢀࡲࡋࡓࠋࡇࡢ࡯࠿ࠊ᪥ᮏ⏕య་ᕤᏛ఍ホ㆟ဨࠊ᪥ᮏ⬦⟶Ꮫ఍ホ㆟ဨࠊ᪥ᮏ㉸㡢Ἴ་Ꮫ఍ྡ㄃఍ဨ࡜ࡋ࡚ࡶࡈά㌍ࡉࢀࡿࡔࡅ࡛࡞ࡃࠊᮾிዪᏊ་⛉኱Ꮫ
㏥ᐁᚋࡶࠊᅜ㝿఍㆟࡞࡝࡟࠾࠸࡚◊✲Ⓨ⾲ࢆ⥆ࡅࠊⱝᡭ◊✲⪅ࡢᡭᮏ࡜࡞ࡗ࡚࠾ࡽࢀࡲࡍࠋ
௨ୖࡢᩘࠎࡢຌ⦼ࡣᒸᑠኳ㈹ཷ㈹࡟ࡩࡉࢃࡋ࠸࡜ࡢホ౯ࡀ࡞ࡉࢀࡲࡋࡓࠋ

㸨⩌㤿኱Ꮫ኱Ꮫ㝔 ᕤᏛ◊✲⛉ ᛂ⏝໬Ꮫ࣭⏕≀໬Ꮫᑓᨷ >ࠛ ⩌㤿┴᱒⏕ᕷኳ⚄⏫ @

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 ≉ูᐤ✏᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍࡬ࡢࡈᣵᣜᵽཱྀ 㝧Ꮚ ௒ᖺࡣ㸪᫖᪥࡟➨ 1 ᅇᅜ㝿ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮࣭ࢩ࣏ࣥࢪ࢔࣒ࡀ㛤࠿ࢀ㸪ᮏ᪥࡜᫂᪥ࡣ᪥ᮏࣂ࢖࢜
ࣞ࢜ࣟࢪ࣮Ꮫ఍ࡢࡈ㛤ദ࡛㸪8 ᭶࡟ࡣᅜ㝿ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࡢࡈணᐃ࡜ࡢࡇ࡜㸪Ꮫ఍ࡢࡈάື
ࡀᅜ㝿ⓗ࡟ᗈࡀࡾ㸪࠾ࡵ࡛࡜࠺ࡈࡊ࠸ࡲࡍ㸬 ᮏ᪥ࡣ㸪Ꮫ఍㛗㇂ୗ୍ኵඛ⏕࡜ᖺ఍㛗Ặᐙᘯඛ⏕ࡢࡈᐶ኱࡞࠾ィࡽ࠸࡛㸪ࡇࡢ᠓ぶ఍࡜᫂᪥ࡢࠕᒸ
ᑠኳ㈹ࠖᤵ㈹ᘧ࡟ฟᖍࡉࡏ࡚㡬ࡁ㸪ࡓࡔ௒ࡣࡈ㥅㉮ᵝ࡟ࡲ࡛࡞ࡾ㸪ࡲࡇ࡜࡟ᜍࢀධࡾࡲࡍ㸬 3 ᪥࡜ 4 ᪥ࡢࣉࣟࢢ࣒ࣛࢆᣏぢ࠸ࡓࡋࡲࡍ࡜㸪⾑⟶㸪⬻ື⬦⒗㸪ィ ᢏ⾡ࡢ㛤Ⓨ㸪㣗ရࡢࣞ࢜ࣟ
ࢪ࣮㸪㧗ศᏊࣞ࢜ࣟࢪ࣮㸪ᚤᑠᚠ⎔㸪㦵ࡢࣂ࢖࢜ࣟࢪ࣮࡜ከᙬ࡛ᩘከࡃࡢ◊✲Ⓨ⾲ࡀ࠶ࡾ㸪㛫࡟Ꮫ⾡ዡບ㈹බເⓎ⾲࡜୕ᅇࡢᏛ఍ㄽᩥ㈹ཷ㈹ㅮ₇ࡀྵࡲࢀ࡚࠾ࡾ㸪ᚰࡼࡾ࠾႐ࡧ⏦ࡋୖࡆࡲࡍ㸬 ᫖ᖺࡢᏛ఍ㄅ➨ 23 ᕳ➨ 1 ྕࡣⱥᩥ࡛Ⓨ⾜ࡉࢀ㸪࠶ࡾࡀࡓࡃ㡬ᡝ࠸ࡓࡋࡲࡋࡓ㸬ୡ⏺ⓗỈ‽ࡢ᭱᪂◊✲ࡀ࠸ࡕ᪩ࡃୡ⏺୰࡟㛤♧ࡉࢀ㸪ඛ⏕᪉ࡢᡂᯝࡀ㏿ࡸ࠿࡟ṇᙜ࡟ホ౯ࡋ࡚㡬ࡅࡿࡼ࠺࡟࡞ࡾࡲࡍ
ࡇ࡜ࢆ㸪ఱࡼࡾᎰࡋࡃᏑࡌ㸪࠾⚃࠸⏦ࡋୖࡆࡲࡍ㸬 1907 ᖺ⏕ࡲࢀࡢ∗ࡀ㸪㧗ศᏊ≀⌮㸪⏕≀≀⌮㸪ࣂ࢖࢜ࣞ࢜ࣟࢪ࣮࡬࡜㐍ࡳ㸪῝⏣ᰤ୍ඛ⏕࡜ࡈ୍⥴࡟᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࢆ๰タ࠸ࡓࡋࡲࡋࡓࡢࡣ 1977 ᖺ࡛ࡋࡓ㸬1990 ᖺ 10 ᭶࡟ஸࡃ࡞ࡾ
ࡲࡍࡲ࡛ࡢ 13 ᖺ㛫㸪Ꮫ఍ࡢඛ⏕᪉࡟ࡣ㠀ᖖ࡟࠾ୡヰ࡟࡞ࡾࡲࡋࡓ㸬ἐᚋࡶ㸪῝⏣ඛ⏕ึࡵ㸪ඛ⏕᪉࡟㸪ᛮ࠸ฟࢆ࠾᭩ࡁ㡬ࡁ㸪኱ኚ࡟ࡈぶษ࡟ࡋ࡚㡬ࡁࡲࡋࡓ㸬∗ࡢ◊✲ෆᐜࡣ⚾࡟ࡣ඲ࡃ⌮ゎ࡛ࡁࡲࡏࢇࡅࢀ࡝ࡶ㸪೺ᗣ࡟ᜨࡲࢀ࡞࠿ࡗࡓ∗࡛ࡋࡓࡀ㸪Ꮫၥ࡟ᑐࡋ࡚ᖖ࡟ㄔᐇ࡛࠶ࡗࡓࡇ࡜㸪ኴᖹὒᡓத๓ᚋࡢ⏕άⱞࡢ᫬௦࡟ࡣ㸪⌧ᅾ࡛ࡣ᝿ീ࡛ࡁ࡞࠸࡯࡝ࡢᅔ㞴ࢆ஌ࡾ㉺࠼࡚ᐙ᪘ࢆᏲࡗ࡚ࡃࢀࡓࡇ
࡜ࢆᛮ࠸ฟࡋࡲࡍ㸬ࡇࡢࡇ࡜ࡣ㸪஑ᕞ኱Ꮫ࡛ࡢᏛ఍࡛㸪୸ᒣᚭᖺ఍㛗ࡢ࠾່ࡵ࡜☾㈅⾜⚽ඛ⏕ࡢࡈᣦᑟ࡛ᑡࡋㄒࡽࡏ࡚㡬ࡁࡲࡋࡓ㸬᭦࡟బࠎᮌ┤ᶞඛ⏕ࡢ࠶ࡾࡀࡓ࠸ࡈᥦ᱌࡛㸪Ꮫ఍ㄅ㹀㸤㹐ࡢ➨ 21
ᕳ➨ 2 ྕ㸪➨ 3 ྕ࡟㍕ࡏࡉࡏ࡚㡬ࡁࡲࡋࡓ㸬 ᖹᡂ 14 ᖺ㸦2002㸧⛅࡟∗ࡢ༑୕ᅇᚷࡀࡍࡳࡲࡋ࡚࠿ࡽ 1 ᖺࡃࡽ࠸ᚋ࡛ࡋࡓ࡛ࡋࡻ࠺࠿㸪∗ࡀ᭱ᚋ࡟኱ኚ࡟࠾ୡヰ࡟࡞ࡾ㸪ᛮ࠸ධࢀࡶ῝࠿ࡗࡓ࡜ᛮࢃࢀࡲࡍࡇࡢᏛ఍࡟㸪ఱ࠿ࡈᜠ㏉ࡋࡀࡋࡓ࠸࡜
ᛮ࠸ࡲࡋ࡚㸪῝⏣ඛ⏕࡜ᙜ᫬ࡢᏛ఍㛗㈅ཎ┾ඛ⏕࡟㸪லᑡࡢࡈᐤ௜ࢆ⏦ࡋฟࡲࡋࡓ㸬ᛮ࠸ࡀࡅ࡞ࡃ
ࡶ㸪ᖹᡂ 16 ᖺ㸦2004㸧᫓㡭࡟㸪ࠕᒸᑠኳᇶ㔠ࠖࢆタ❧ࡋ㸪ࠕᒸᑠኳ㈹ࠖࢆไᐃࡋ࡚ୗࡉ࠸ࡲࡋࡓ㸬ࡑࡢ⤖ᯝ㸪ᖹᡂ 16 ᖺᗘ㸦2004㸧☾㈅⾜⚽ඛ⏕㸪Ლ㇂ᩥᙪඛ⏕㸪17 ᖺᗘ㸦2005㸧㈅ཎ┾ඛ⏕㸪18
ᖺᗘ㸦2006㸧ὸ㔝∾㔜ඛ⏕㸪19 ᖺᗘ㸦2007㸧⚄㇂░ඛ⏕㸪20 ᖺᗘ㸦2008㸧すᡂ຾ዲඛ⏕㸪21 ᖺᗘ㸦2009㸧㔠஭ᐶඛ⏕㸪22 ᖺᗘ㸦2010㸧Ⳣཎᇶ᫭ඛ⏕ࡢࡈཷ㈹࡜࡞ࡾ㸪ࡇࡢ୐ᖺ㛫࡟ඵྡࡢ᪉ࠎ࡟
ࡈ㉗࿊⏦ࡋୖࡆࡲࡍࡇ࡜ࡀ࡛ࡁ㸪ࡇࡢୖ࡞ࡃගᰤ࡟Ꮡࡌ࡚࠾ࡾࡲࡍ㸬 ᮏᖺᗘࡣࠕᒸᑠኳᇶ㔠ࠖࡀ Journal of Biorheology ࡢฟ∧㈝⏝ࡢ୍㒊࡟ࡶ඘ᙜࡉࢀࡲࡍ⏤㸪኱ኚ࡟ព⩏࠶ࡿ౑㏵࡛࠶ࡿ࡜Ꮡࡌࡲࡍ㸬᪥ᮏㄒㄽᩥࡣ᪥ᮏ௨እ࡛ࡣ࡯࡜ࢇ࡝ㄞࢇ࡛㡬ࡅࡲࡏࢇ࡛ࡋࡻ࠺㸬 ࡲࡓ㸪ᖹᡂ 16 ᖺ㸦2004㸧9 ᭶࡟ࡣ㸪ෆᮧຌ᪂఍㛗ࡢࡈዲព࡛㸪ࠕᒸᑠኳᩥᗜࠖࢆタ❧ࡋ࡚㡬ࡁ㸪ᡭඖ࡟ࡈࡊ࠸ࡲࡋࡓഹ࠿࡞᭩⡠㸪㑇ရ➼ᑡࠎࢆᏛ఍࡛ಖ⟶ࡋ㸪ࡈ฼⏝ࡋ࡚㡬ࡅࡿࡇ࡜࡟࡞ࡾࡲࡋࡓ㸬᪥㐍᭶Ṍࡢ⮬↛⛉Ꮫࡢศ㔝࡛ࡣ㸪ྂ࠸᭩⡠࡟ࡣ㈨ᩱⓗ౯್ࡋ࠿࡞࠸࠿ࡶࡋࢀࡲࡏࢇࡀ㸪∗ࡀ኱ษ࡟

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ࡋ࡚࠾ࡾࡲࡋࡓ᭩≀ࢆ࠾ཷࡅྲྀࡾ㡬ࡅࡲࡋ࡚㸪ࡇࢀ࡯࡝Ꮀࡋ࠸ࡇ࡜ࡣࡈࡊ࠸ࡲࡏࢇ࡛ࡋࡓ㸬ᮏᖺᗘ࠿ࡽ๪఍㛗ࡢチ࡛ࡢࡈᡤⶶ࡟࡞ࡾࡲࡍࡑ࠺࡛㸪ࡇࢀ࠿ࡽ⩌㤿኱Ꮫᅵᶫᩄ᫂ඛ⏕ࡢ◊✲ᐊ࡟⛣ࡾࡲࡍ㸬㈚ࡋฟࡋ➼㸪ࡈ㠃ಽࢆ࠾࠿ࡅ࠸ࡓࡋࡲࡍࡀ㸪ࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍ㸬ࠕᩥᗜࠖ࡟୍ᮏ࠾཰ࡵࡋ
ࡓࡢ࡜ྠࡌ࢝ࢭࢵࢺ࣭ࢸ࣮ࣉ㸦ᑠᯘ㔗⏨࣭ᒸᑠኳ㸧ࢆ஧ᮏᣢཧࡋ㸪㇂ୗඛ⏕࡟࠾㡸ࡅ⏦ࡋୖࡆࡲࡍ
ࡢ࡛㸪ࡶࡋࡈᕼᮃࡢඛ⏕ࡀ࠾ࡽࢀࡲࡋࡓࡽ㸪㇂ୗඛ⏕࡟࠾⏦ࡋฟୗࡉ࠸ࡲࡏ㸬࢝ࢭࢵࢺ࣭ࢸ࣮ࣉ࡛
ࡍࡢ࡛㸪ఱಶ࡛ࡶࢥࣆ࣮࡛ࡁࡲࡍ㸬㹁㹂࡛ࡣ࡞࠸ࡢ࡛㸪㡢Ⰽࡣ࠶ࡲࡾࡼࡃࡈࡊ࠸ࡲࡏࢇ㸬 ᮏᖺ 10 ᭶ 20 ᪥࡟ࡣ㸪∗ࡀஸࡃ࡞ࡗ࡚‶஧༑ᖺ⤒ࡕ㸪ࠕᒸᑠኳ㈹ࠖࡶࣛࢵ࣮࢟ࢭࣈࣥࡢ୐ᅇࢆ㏄࠼ࡲࡍ㸬⚾ࡣ 2000 ᖺ 4 ᭶࠿ࡽ‶༑ᖺ໅ࡵࡲࡋࡓ㮵ඣᓥᅜ㝿኱Ꮫࢆ 3 ᭶ 31 ᪥࡛ᐃᖺ㏥⫋ࡋ㸪෌ࡧᮾி࡛ᬽࡽࡋጞࡵࡲࡋࡓ㸬9 ᭶࡟ࡣᚋᮇ㧗㱋⪅࡟࡞ࡾ㸪࠸ࡘఱࡀ㉳ࡁ࡚ࡶ࠾࠿ࡋࡃ࡞࠸ᖺ㱋࡟࡞ࡾࡲࡋ
ࡓ㸬௒ࡲ࡛㸪ᜍ⦰࡞ࡀࡽᤵ㈹ᘧ࡟ฟᖍࡉࡏ࡚㡬࠸࡚࠾ࡾࡲࡋࡓࡀ㸪᮶ᖺ௨㝆ࡣᏛ఍㛗࡜ᖺ఍㛗࡟ࡈ୍௵⏦ࡋୖࡆࡓࡃ㸪ࡼࢁࡋࡃ࠾㢪࠸⏦ࡋୖࡆࡲࡍ㸬ࡲࡓ㸪ࠕᒸᑠኳᇶ㔠ࠖࡢ౑⏝┠ⓗࡶ㸪ࡈ஦᝟࡟ྜ
ࢃࡏ࡚ࡈ⮬⏤࡟࠾Ỵࡵ㡬ࡅࢀࡤࡼࢁࡋ࠸࠿࡜Ꮡࡌࡲࡍ㸬ᖺᗘᮎ࡟࡛ࡶ㸪
ࠕᒸᑠኳ㈹ࠖࡢཷ㈹⪅ࡢࡈẶྡ㸪ࠕᒸᑠኳᇶ㔠ࠖࡢ௚ࡢ౑㏵࡞࡝㸪ཬࡧ཰ᨭሗ࿌ࢆ࠾▱ࡽࡏ㡬ࡅࡲࡍࢀࡤ࠶ࡾࡀࡓࡃᏑࡌࡲࡍ㸬 ௒ࡲ࡛ࡣᏛ఍ㄅࢆࡈᜨ㏦㡬ࡁ㸪ᕳ㢌ゝ࡞࡝࡟ឤࡌධࡗ࡚࠾ࡾࡲࡋࡓࡀ㸪᪥ᮏㄒ࡛ࡶ◊✲ෆᐜࡣ⊧࡟ᑠุ࡛ࡈࡊ࠸ࡲࡋࡓ㸬ⱥᩥ࡜ᩘᘧࡢ➨ 23 ᕳ➨㸯ྕࡣ㸪㇜࡟┿⌔࡝ࡇࢁ࠿㸪ࢦ࢟ࣈࣜ࡟ࢲ࢖࡛ࣖࡈ
ࡊ࠸ࡲࡋࡓ㸬⚾ࡀ㡬ࡁࡲࡋ࡚ࡣࡶࡗࡓ࠸ࡢ࠺ࡈࡊ࠸ࡲࡍࡢ࡛㸪௒ᚋࡣࡈ㎡㏥⏦ࡋୖࡆࡲࡍ㸬㧗౯࡛㈗㔜࡞Ꮫ఍ㄅࡣ㸪୍㒊࡛ࡶవィ࡟ᾏእࡢᅗ᭩㤋㸪◊✲ᡤ➼࡟࠾㏦ࡾ㐟ࡤࡋࡲࡍࡼ࠺࠾㢪࠸⏦ࡋୖࡆࡲࡍ㸬 ᭱ᚋ࡟࡞ࡾࡲࡋࡓࡀ㸪ㅖඛ⏕ࡢࡈ೺຾࡜㸪ࡈά㌍࡜㸪᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࡢ୍ᒙࡢࡈⓎᒎࢆ࠾♳ࡾࡋ㸪ᚰ࠿ࡽࡢឤㅰࢆᤝࡆ࡚㸪ᣋ࠸ࡈᣵᣜࢆ⤊ࢃࡽࡏ࡚㡬ࡁࡲࡍ㸬㛗࠸㛫㸪ࡈΎ⫈࠶ࡾࡀ࡜࠺ࡈࡊ࠸ࡲࡋࡓ㸬ͤᒸᑠኳඛ⏕ࡢࡈ㑇᪘࡛࠶ࡾࡲࡍᵽཱྀᵝࡢ 2010 ᖺ 6 ᭶ 3 ᪥㸦ᮌ㸧ࡢ➨㸱㸱ᅇᖺ఍᠓ぶ఍࡛ࡢࡈᣵ
ᣜࡢཎ✏ࢆࡑࡢࡲࡲᥖ㍕ࡉࡏ࡚㡬ࡁࡲࡋࡓ㸬

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Journal of Biorheology ࡬ࡢࡈᢞ✏ࡢ࠾ㄏ࠸
Journal of Biorheology ⦅㞟ጤဨ఍  ᖺ  ᭶࡟ -RXUQDORI%LRUKHRORJ\㸦-%5㸧 ᕳ➨  ྕࢆⓎหࡋ  ᖺࡀ⤒ࡕࡲࡋࡓ㸬ࡇࡢ㛫 ᕳ➨  ྕࢆ  ᖺ  ᭶࡟ⓙᵝࡢୗ࡟࠾ᒆࡅ࠸ࡓࡋࡲࡋࡓ㸬㐜ࢀẼ࿡࡛ࡣ࠶ࡾࡲࡍࡀ㸪 ᕳ➨  ྕࡣ༳ๅࢆ㛤ጞ࠸ࡓࡋ࡚࠾ࡾࡲࡍ㸬ࣞࣇ࢙࣮ࣜࢆ໅ࡵࡽࢀࡓඛ⏕᪉ࡢ࠾㝜࡛ᢞ✏ࡉࢀࡿཎ✏ࡢ㉁ࡀᨵၿࡉ
ࢀ㸪ᢞ✏ᩘࡶቑ࠼ࡘࡘ࠶ࡾࡲࡍ㸬ࡲࡓ㸪ᅜෆࡢࡳ࡞ࡽࡎᾏእ࠿ࡽࡢᖖ㐃ᢞ✏⪅ࡶฟ࡚ࡁ࡚࠸ࡲࡍ㸬 ࡇࡢᶵ఍࡟㸪఍ဨࡢඛ⏕᪉࠿ࡽࡶ᫝㠀ࡈᢞ✏࠸ࡓࡔࡁࡓࡃ㸪ࡇࡇ࡟࠾㢪࠸⏦ࡋୖࡆࡲࡍ㸬Ꮫ఍఍๎࡛ࡣ㸪ࠕ᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍ࡣࣂ࢖࢜ࣞ࢜ࣟࢪ࣮ศ㔝ࡢ◊✲Ⓨᒎࢆ┠ⓗ࡜ࡋ㸪ࡑࡢ┠ⓗ㐩ᡂࡢࡓࡵࡢᰕࡢ୍ࡘࡀᏛ⾡㞧ㄅࡢⓎ⾜࡛࠶ࡿࠖ࡜ࡉࢀ࡚࠸ࡲࡍ㸬-RXUQDORI%LRUKHRORJ\ ࡢห⾜ࡀ⥆ࡁ㸪ᥖ㍕ࡉࢀࡿㄽᩥࡢ㉁ࡀ㧗ࡃ࡞ࡿ࡞ࡽࡤ㸪ࡑࡢࡇ࡜ࡣᚲࡎᏛ఍ࡢ DFWLYLW\ ࡟཯ᫎࡉࢀࡿࡶࡢ࡜⪃࠼ࡽࢀࡲࡍ㸬᫝㠀 -RXUQDORI%LRUKHRORJ\ ࡬ࡢࡈᢞ✏ࢆ࠾㢪࠸⏦ࡋୖࡆࡲࡍ㸬ࡲࡓ㸪ⓙᵝࡀඹྠ◊✲࡞࡝ࡉࢀ࡚࠸ࡿᾏእ◊✲⪅࡟ࡶㄽᩥᢞ✏ࢆ࿧ࡧ࠿ࡅ࡚࠸ࡓࡔࡁࡓࡃ㸪ࡇࡇ࡟࠾㢪࠸⏦ࡋୖࡆࡲࡍ㸬-RXUQDORI%LRUKHRORJ\㸦㏻⛠㸸-%5㸧ࡢ 85/ ࡣ㸪
http://www.springer.com/physics/biophysics+%26+biological+physics/journal/12573
࡛ࡍ㸬ࡇࡇ࠿ࡽ RQOLQHᢞ✏ࡀ࡛ࡁࡲࡍ㸬

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᪥ᮏࣂ࢖࢜ࣞ࢜ࣟࢪ࣮Ꮫ఍఍ဨࡢⓙᵝ ➨  ᅇࣂ࢖࢜ࣞ࢜ࣟࢪ࣮࣭ࣜࢧ࣮ࢳ࣭ࣇ࢛࣮࣒ࣛࢆୗグࡢ᪥᫬࡟ᮾி኱Ꮫ࡛㛤ദࡋࡲࡍ㸬௒ᅇࡢࢸ࣮࣐ࡣࠕ⣽⬊ࡢᣲື࡜ࣞ࢜ࣟࢪ࣮࡛ࠖࡍ㸬⣽⬊ࡢศ⿣ࡸ㐠ື࡜࠸ࡗࡓᇶᮏⓗ࡞ᣲືࡣ⏕࿨ࡢ⥔ᣢࡸᙧែᙧᡂ࡟࠾࠸࡚ᚲ㡲ࡢ࢖࣋ࣥࢺ࡛࠶ࡿ࡟ࡶ㛵ࢃࡽࡎ㸪ࡑࡢ≀⌮ⓗ࡞ᛶ㉁ࡢヲ⣽࡟ࡘ࠸࡚ࡣ୙᫂࡞Ⅼࡀከࡃṧࡉࢀ࡚࠸ࡲࡍ㸬ᮏࣇ࢛࣮࣒࡛ࣛࡣ⣽⬊ࡢ◊✲ࢆ࡝ࡢࡼ࠺࡞᪉ἲ࡛㐍ࡵ࡚࠸ࡃࡢ࠿㸪ࡲࡓ㸪⌧ᅾ࡝ࡇࡲ࡛ศ࠿ࡗ࡚࠾ࡾఱࡀၥ㢟࡞ࡢ࠿ࢆࡈㅮ₇࠸ࡓࡔࡃணᐃ࡛ࡍ㸬᭱᪂ࡢ◊✲ᡂᯝࢆࡶ࡜࡟ศ࠿ࡾ᫆ࡃゎㄝࡋ࡚࠸ࡓࡔࡁࡲࡍࡢ࡛㸪ከᩘࡢⓙᵝࡢࡈཧຍࢆ࠾ᚅࡕ
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