Vol. 14 No. 1 (2009)

English pages

The 16th Annual Meeting of theJapanese Society of Immunotoxicology(JSIT2009)

16:15-18:00

Oral Presentations

18:30-20:30

Reception(Asahikawa Grand Hotel)

August 27-28,2009■August 28, 2009 (Friday)

Asahikawa Cultural Hall , Asahikawa, Hokkaido, Japan

9:00

Registration

Tel: 0166-25-7331, Fax: 0166-22-3526

9:10-10:55

Oral Presentations

Organizing Committee of the 16th Annual Meeting of

9:00-14:00

Poster Presentations

JSIT

11:00-12:00

Special Lecture II

President :Takahiko Yoshida, Asahikawa Medical College

Role of Zoo

Secretary General : Toshihiro Itoh,

Masao Kosuge

Asahikawa Medical College(Director Emeritus of Asahikawa

Mail Address : jsit16@asahikawa-med.ac.jp

Asahiyama Zoo)

URL : http://www.asahikawa-med.ac.jp/dept/mc/

12:15-13:00

healthy/jsit16/

Luncheon Seminar(Charles River Laboratories)

13:00-13:55

Poster Discussion

Program (tentative Schedule)

14:00-15:30

Oral Presentations■ August 27, 2009 (Thursday)

15:35-17:15

Workshop

9:00

Registration

Standardization of

9:20

Opening Remark

an immunotoxicity test:

9:30-18:00

Poster Presentations

T cell-dependent antibody

9:25-10:55

Oral Presentations

response to keyhole limpet

11:00-12:00

Special Lecture I

hemocyanin

Does immunomodulation early（Organized by Drs. N. Tsutsui

in life increase disease risk inand S. Hisada）

children and beyond?

Naohisa Tsutsui

Dori R. Germolec(Mitsubishi Tanabe Pharma Co.)

（NIEHS, NIH, USA）

Ryota Kawai

Luncheon Seminar(Daiichi Sankyo Co. Ltd.)(Huntingdon Life Sciences)

Kanako Mori

13:00-13:30

General Assembly(Takeda Pharmaceutical Co. Ltd.)

13:30-14:15

Oral Presentations

Hiroyuki Komatsu

14:20-16:10

Symposium(SUGI Institute ofChildren and Immunity

Biological Science Co., Ltd.)

12:15-13:00

Hideki Harada（Organized by Drs. F. Kayama(Mitsubishi Chemical Medience Co.)and K. Nakamura）
Shou Ishikawa

17:15-17:20

Awards Ceremony(The University of Tokyo)

17:20-17:25

Closing Remarks

Chisato Mori (Chiba University),
Judith T. Zelikoff(New York University, USA)─ 15 ─

ImmunoTox Letter
Evaluation of the enhancing effects ofenvironmental chemicals on allergic
diseaseselucidating clear causative product-chemical relationship,3) improvement in material(chemical) safety data sheet(MSDS) and product labeling of household products.

Hirohisa Takano, Rie Yanagisawa,
Eiko Koike, Ken-ichiro Inoue.

Keywords: household product, health damage, allergic(Environmental Health Sciences Division,contact dermatitis, cause investigation, causative

National Institute for Environmental Studies)

product-chemical relationship

Abstract

To whom cor respondence should be addressed:

Changes in environmental factors, rather than those

Masa-aki Kaniwa; Kamiyoga 1-18-1, Setagaya, Tokyoin genetic factors, are thought to be responsible for

158-8501, J a p a n ; P h o n e : +81-3-3700-9243; F a x :the recent increase in allergic diseases. An increase in

03-3707-6950; E-mail: kaniwa@nihs.go.jp

environmental chemicals can be involved in the recentchanges in the environment. We have reported that diesel
exhaust particles (DEP) can enhance allergic asthma.

Recent progress on immunogenicity
assessment of therapeutic
monoclonal antibodies

Organic chemicals in DEP predominantly enhanceallergic inflammation. Furthermore, di-(2-ethylhexyl)
phthalate (DEHP) as a plasticizer also enhances allergic

Naohisa Tsutsui

inflammation. Evaluation of the enhancing effects of(Safety Research Laboratory, Research Division, Mitsubishi

environmental chemicals on allergic diseases should beTanabe Pharma Corporation)

important for the remedy of allergic diseases.
In this March, the European Medicines Agency (EMEA)
unveiled a concept paper in which BMWP/CHMP/EMEA

Trends of Preventive Measures against
Health Damage in Household Products,
associated with Cause Investigation of
Health Damage such as Allergic Contact
Dermatitis due to Chemicals
in Household Products

recommended drafting a guideline on immunogenicity
assessment of monoclonal antibodies intended for invivo clinical use. Recent progress on immunogenicity
assessment of therapeutic monoclonal antibodies isconsidered to be behind that. This short document
provides the four presumable reasons why drafting theMasa-aki Kaniwa

guideline is now necessary: 1) difficulty in measuring(Division of Medical Devices,antibodies against antibodies, 2) necessity of a risk-based

National Institute of Health Sciences)

strategies for the assessment, 3) development of in silico
tools for predicting immunogenicity and 4) emergence ofAbstract

biosimilar products.

Chemicals in household products have been paid muchattention as main cause of health damage in consumers,such as allergic contact dermatitis (ACD). Cause
investigation in cases of ACD due to chemicals in fabric,plastic and rubber products for household uses, arereviewed，focusing on 1) cause investigation, throughcollaborative activities among patients(consumers),dermatologists, toxicologists, manufacturers of chemicals
and household products, chemists, consumer supporting
associations and so on, in combination with bio-assay
and chemical assay methods, 2) case studies on ACD, for─ 16 ─

Vol. 14 No. 1 (2009)

Young power for immunotoxicological research

The structure and Immunochemical activityof the carbohydrate chain
Shinobu SAKAI, Ph. D.
(Senior Researcher)

Division of Novel Foods and Immunochemistr y,
National Institute of Health Sciences
Recently, it is recognized that the carbohydrate chain
contributes to the higher functions of the immunesystem. However, it remains a significant challenge
to reveal the relationship between the structure andfunctions of the carbohydrate chains. In this letter, I
introduce the structure and immunochemical activityof the carbohydrate chain. I believe it is important toadvance these studies using the immunotoxicologicalapproach.

─ 17 ─