ImmunoTox Letter
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E-mail: jsit17@nies.go.jp

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Youngpowerfor immunotoxicological research7「免疫毒性研究の若い力」

The theme of the upcoming meeting is“Immunotoxicology and Susceptibility”

Food and Immunity
Terumi Katori(Hatano Research Institute, Food and Drug Safety Center, Japan)

My graduate studies had been started by a researchon the effect of feeding behavior and light-dark cycle on
immune cell populations in blood of mice. It was shown inthis research that all of B, T and NK cell populations inblood were increased by feeding, and that the variation of
B and NK cells except T cells was synchronized with thereversed light-dark cycle. It was extended to investigate
the ef fect of some phyto-materials on behavioral
indicators for learning and memory and on immune cellbalance in Senescence-accelerated mice (SAM). As theresult some phyto-materials were found to prevent theSAM mice from declining of behavioral activities andimmune depression with aging.
Now in the Hatano Research Institute, I am engaged
in the study about developing an in vitro assay system
for assessment of food allergenicity using Peyer’s patch
cells. I will make an effort to the utmost so as to be likeresearch experts in immunology and toxicology.

Program (Tentative Schedule)■September 9, 2010 (Thursday)
9:00

Registration

9:40

Opening Remark

9:50-18:00 Poster Presentations
9:50-11:05 Oral Presentations
11:10-12:10 Invited Plenary lecture: Mast cells: Integral to the expression ofinnate and acquired immunity (Prof. A.
D. Befus, Univ. of Alberta, CANADA)
12:15-13:00 Luncheon Seminar 1: Charles River
Laboratories
13:05-13:45 General Assembly
13:50-15:50 Symposium: Immunotoxicity and chemicalsusceptibility
Dr. Gar y R. Burleson (BRT-Burleson
Research Technologies, Inc.)「Influenza viral disease: Dexamethasone
and the role of age and genetics on viraldisease severity」
Dr. Tetsurou Ishii (University of Tsukuba)

The 17th Annual Meeting of the JapaneseSociety of Immunotoxicology (JSIT2010)「Oxidative stress-induced responses

September 9-10, 2010

Dr. Naoki Kunugita（National Institutein macrophages: roles of transcription
factor Nrf2 and induced proteins.」of Public Health）「Effects of volatileorganic compounds (VOCs) exposure onOhyama Memorial Hall

immunotoxicity in mice」

National Institute for Environmental Studies

Dr. Takamichi Ichinose (Oita UniversityTsukuba, Ibaraki 305-8506 Japan
Organizing Committee of the 17th Annual Meeting ofof Nursing and Health Sciences)「AsianJSIT

sand dust and allergy」
Dr. Reiko Teshima (National Institute ofURL http://jsit2010.umin.ne.jp

Health Sciences)「Effect of chemicals
President: Hidekazu Fujimaki, National Institute forlike brominated flame retardants on theEnvironmental Studies

development of the immune system in

Secretary General: Keiko Nohara, National Instituterodents」
15:55-16:55 Oral Presentations

for Environmental Studies

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Vol. 15 No. 1 (2010)

Ozone and Immunotoxicity

17:00-18:00 Special Lecture: Molecular mechanisms

Hidekazu Fujimaki

underlying pathogen sensing in the innate（National Institute for Environmental Studies）

immune system Prof. Kensuke Miyake(The Institute of Medical Science, The
University of Tokyo)
18:30-20:30 Reception (Chateau Kamiya)■September 10, 2010 (Friday)
8:40

Registration

9:00-13:45 Poster Presentations
9:10-10:00 Oral Presentations (Student session)
10:05-11:20 Oral Pserentations
11:25-12:10 Master’s Lecture: Allergenicity testing:current and future issues
Dr. Jun-ichi Sawada (Pharmaceuticals andMedical Devices Agency )12:15-13:00 Luncheon Seminar 2: Huntingdon LifeSciences
13:05-13:45 Poster Discussion
13:50-15:05 Oral Pserentations
15:10-17:10 Workshop(Organized by Drs. E. Maki and Y. Kouchi)
17:10-17:15 Awards Ceremony
17:15-17:20 Closing Remarks

Indoor and outdoor pollutants may be associated withhealth problems. Ozone is one of the outdoor pollutants
and it is suggested a positive relationship between lowlevel ozone exposure and increased incidence of allergic
diseases in developed countries.
Little is known about the mechanism of action ofozone to induce allergic responses and its susceptible
subpopulation. However, there are rapidly growing
evidences suggesting that ozone can modify airway
inflammatory responses by disrupting the anti-oxidant
mechanism that may regulate the nervous and immune
functions.
Here, based on the data from animal experiments, I
summarized the role of ozone in the induction of lunginjury and airway inflammation and then discussed thesusceptibility to toxic chemical exposure and predisposing
allergic and infectious diseases. I also consider thepossible mechanisms by which ozone exposure caninduce the symptoms presenting in patients with airway
hyperactivity.
Exposure to an allergen and/or toxic chemical ozone
leads to epithelial cell irritation and it triggers cytokine
production from these epithelial cells and alveolar
macrophages.
In this review, I have highlighted the potential
inflammator y mediators that influencing air way
hyperreactivity by ozone inhalation and I hope
this review, at least in part, help to understand themechanisms of allergic diseases caused by chemicals
around us.

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