The 16th Annual Meeting of JSIT
2009.8.27-28. Asahikawa City Cultural hallPresident: Takahiko Yoshida, Department of Health Science, Asahikawa Medical
College, Asahikawa, Japan
Special Lecture IDoes(1) National Toxicology Program,
immunomodulation
National Institute of Environmental
Germolec Dori R (1)，early in life increase
Health Sciences
Dietert Rodney R (2)disease risk in children(2) Department of Microbiology andand beyond?
Immunology, Cornell University
Special Lecture II
Role of Asahiyama Zoo Masao Kosuge

Director Emeritus of Asahikawa
Asahiyama Zoo

Symposium
Organizer
Children and Immunity Fujio Kayama
Kazuichi Nakamura
Breakdown of mucosal
immunity in the gutand allergic
sensitization by dioxin

Sho Ishikawa

Health examination
system to prevent fetal
exposure of persistent
Chisato Moriorganic pollutants(POPs) and atopic
dermatitis in infants.
Prenatal exposure tocigarette smoke
increases tumor
susceptibility ofjuvenile mice via
changes in anti-tumor
immune mechanisms

Zelikoff Judith T (1)，
Ng Sheung P (1)，
Yoshida Kotaro (1)，Silverstone Allen E(.2)，Lai Zhi-Wei (2)Jichi Medical University
Shionogi & Co., Ltd.
Dept of Molecular PreventiveMedicine, The University of Tokyo,
Tokyo, Japan
Center of Preventive Medical Science,
Department of Bioenvironmental
Medicine, Graduate School Medicine,Center for Environment, Health andField Sciences, Chiba University
1) New York University School ofMedicine, Nelson Institute ofEnvironmental Medicine
2) SUNY Upstate Medical University,
Department of Microbiology &Immunology

WorkshopStandardization of an
Organizer
immunotoxicity test: T
cell-dependent
Naohisa Tsutsui
antibody response tokeyhole limpet
Shigeru Hisada
hemocyanin

Mitsubishi Tanabe Pharma Co.

Background for a
discussion on
standarized protocolsof KLH-TDAR

Safety Research Laboratory,Research Division, Mitsubishi Tanabe
Pharma, Chiba, Japan

Naohisa TsutsuiAska Pharmaceutical Co., Ltd.

Case 1: Rat strain
comparison of T cell

Ryota Kawai，ShihoIto，Hiroyuki

dependent antibody

HattoriI，Tetsuo

response using keyhole Aida，Tadashi
limpet hemocyanin as
an antigen

Furukawa，Atsushi
Sanbuissho

Medicinal Safety ResearchLaboratories, DAIICHI SANKYO CO.,LTD.

Kanako Mori，Takako
Case 2: Protocol for

Iwachido，Masami

Rat KLH-TDAR inAoki，Hideki
Takeda Pharmaceutical Yamasaki，KenjiCompany Limited

Takami，Hirofumi

Development Research Center,
Pharmaceutical Division, Takeda
Pharmaceutical Company Limited

Nagai
Case 3:TDAR method
using the commercial
anti KLH-ELISA kit -Horoyuki Komatsu

SUGI Institute of Biological Science

Hideki Harada，Makoto Tsunimi，Hideki Tokudome，
Takayuki Okamura，Yasuyuki Oonishi，Hideaki Hiratsuka

Kashima Laboratory, Toxicological
Science Division, Medi-ChemBusiness Segment, Mitsubishi
Chemical Medience Corporation

Assessment of theinfluence of possible
endocrine disruptors
on the development of
non-pathogenicbacterial induced
infectious diseases

Noriko Mizutani(1),Masashi Muroi(1,2),
Arisa Igarashi(1),Shinji Kanno(1),Yoichi Kamata(1),Yoshiko Konishi(1),Ken-ichi
Tanamot(1,2)(1) Division of Microbiology, National
Institute of Health Sciences, Tokyo,Japan, (2) Faculty of Pharmacy,
Department of PharmaceuticalSciences, Musashino University,Tokyo, Japan

Estrogen receptors inrainbow trout immune
organs and cells

Nakayama Ayako(1)，Koellner Bernd(2)，Eppler Elisabeth(3)，Segner Helmut(1)(1) Centre for Fish and Wildlife
Health, University of Bern, (2)Friedrich-Loeffler-Institute, (3)Research Group Neuro-EndocrineImmune Interactions, University ofZurich

Effects of exposure tophthalates on atopic
dermatitis-like skinlesions in NC/Nga mice

Rie Yanagisawa，
Environmental Health Sciences
Hirohisa Takano，Eiko Division, National Institute for
Koike，Ken-ichiro
Environmental Studies, Tsukuba,InoueJapan

Allergic reaction
induced by dermal
and/or respiratory
exposure to several
types of pesticides

Tomoki Fukuyama,
Yukari Tajima, Koichi
Hayashi, Hideo Ueda, The Institute f Environmental
Yasufumi
Toxicology, Toxicology Division,
Shutoh,Takanori
Ibaraki, Japan
Harada,Tadashi
KosakaSuppression of airway
responsiveness andeosinophilic infiltrationin asthmatic mice bypropolis

Ryoji Hirota(1),Masamitsu Eitoku(1),Ken-ichi Yagyu(2),Hiroyuki Tanaka(3),Naoki Inagaki(3),Comparison with SRBC
methodCase 4: Case study ofboth anti-KLH IgM andIgG antibody
measurement in TDAR
testing
Oral Presentations(1)Department of Environmental
Medicine, Kochi Medical School
Kohasu, Kochi, Japan, (2)TheScience Research Center, Kochi
University, (3 Bioactive Molecules,

Hiroichi Nagai(3),HiroyukiGifu Pharmaceutical University,(4)Department of Environmental andNakamura(4),Preventive Medicine, Kanazawa

Narufumi

University Graduate School ofSuganuma(1)Medical Science.

Effect of ziram, aQing Li，Maiko

Department of Hygiene and Publiccarbamate pesticide,

Kobayashi，Tomoyuki Health, Nippon Medical School,on human NK activity

KawadaDevelopment of aNakamura Ryosuke，Tokyo, Japannovel allergy test using Yoshimi Uchida，Div. Novel Foods Immunochem.,

a cultured mast cell

Masakazu Higuchi，Natl. Instit. Health Sci., Tokyo, Japanline

Reiko Teshima
Terumi Katori(1),A new In Vitro assay

tomoko Shindo(1),(1) Hatano Research Institute, Food

Yukiko Kanazawa(1), and Drug Safety Center, Hadano,system for assessment
Motoyasu Ohsawa(1), Japan,(2) National Institute of Healthof food allergenicity
Kohichi Kojima(1),Sciences, Tokyo, Japan
reiko Teshima(2)(1) Safety Assessment Dept., Fuji
Gotemba Res. Labs., Chugai
Pharmaceutical Co., Ltd., Gotemba,
Japan, (2)Pharmaceutical Res. Dept.
2, Kamakura Res. Labs., Chugai
Pharmaceutical Co., Ltd., Kamakura,Japan

Potential use of humanerythropoietin
transgenic mousemodel as a tool for
immunogenicity
assessment

Akifumi Shioda(1),Ryousuke
Watanabe(2),Tomoaki Inoue(1),Masayuki Mishima(1)Effect of prenatal andpostnatal exposure tolow-level toluene onimmune development
in infant mice

(1) Research Center for
Environmental Risk, National
Shoji Yamamoto(1),Institute for Environmental Studies,
Win-Shwe Tin-Tin(1),Tsukuba, Japan, (2)Depertment of
Naoki Kunugita(2),Environmental Health, National
Yasuhiro Yoshida(3),Institute of Public Health, Wako,
Keiichi Arashidani(3),Japan, (3)University of Occupational
Hidekazu Fujimaki(1)and Environmental Health,
Kitakyushu, JapanThe effect of DPH andMXC on the immune
response to SRBCantigen in infant andadult female rats

Koichi Hayashi，Tomoki Fukuyama，
Yukari Tajima，YukikoKashimoto，Hideo
Institute of Environmental
Ueda，Yasufumi
Shutoh，TakanoriHarada，Tadashi
KosakaEffect of arsenite on
lipopolysaccharide-Seiichiro Himeno，Koichiro Matsuda，

induced activation ofmouse macrophages

Hiromasa Tsuyama，
Hitomi Fujishiro

Benzo[a]pyreneinduced activation ofToxicology, Ibaraki Japan

Eiko Koike，KenIchiro Inoue，Rie

Laboratory of Molecular Nutrition andToxicology, Faculty of PharmaceuticalSciences, Tokushima Bunri University
Environmental Health Sciences
Division, National Institute formurine immune cells

Yanagisawa，Hirohisa Environmental Studies,Tsukuba,
TakanoJapan

Effects ofTomonori Hayashi(1), (1) Radiation Effects Researchinflammation-related
gene polymorphisms

Waka Ohishi(1),Foundation, Hiroshima, Japan, (2)Kazue Imai(1), Kengo Central Research Facility, Hiroshima

and atomic-bombYoshida(1), Ikue

radiation exposure onHayashi(2), Saeko

University Faculty of Dentistry,risks of stomach andliver cancers

Fujiwara(1), Yoichiro
Kusunoki(1), Kei

Hiroshima, Japan

Nakachi(1)Yoshiro Saito(1,2),
Nahoko Kaniwa(1,2),
Masahiro Tohkin(1,2),
Kouichi Kurose(1,2),
Jun-ichi Sawada(1),Associations between
HLA alleles andKayoko
Matsunaga(2),Stevens-Johnson
Yukitoshi
syndrome and toxicTakahashi(2),epidermal necrolysis in Hirokazu Furuya(2),Japanese patients(Second report)(1) National Institute of HealthSciences,(2) JSAR Research Group

Masaaki
Muramatsu(2), ChieSotozono(2), Shigeru
Kinoshita(2), MichikoAihara(2), Zenro
Ikezawa(2), Ryuichi
Hasegawa(1,2)(1) The Center for Advanced Medical
Yasuo Yoshioka(1,2),
Tomohiro
Morishige(2), Hiroshi

Systematic evaluation

Inakura(2), AyaTanabe(2), Yasuo

between particle
characteristics of silica

Tsutsumi(1,3,4),
Shin-ichi Tsunoda(4),and inflammatory
responsesYuichi Kawai(5),Tadanori Mayumi(5),Yohei Mukai(2), ，Naoki Okada(2),Shinsaku
Nakagawa(1,2)

Megumi Maeda(1),Enhancement of
Ying Chen(1), Hiroaki
suppression function ofHayashi(1), Naoko
MT-2 cells on T cell
Kumagai(1), Yoshie
proliferation by longMiura(2), Yasumitsu
term and low-level
Nishimura(1), Takemi
exposure to asbestos
Otsuki(1)Involvement ofcytokines insuppressed inductionof CTL upon exposure
to asbestos
Analysis forEngineering and Informatics, Osaka
University, Osaka, Japan, (2)Department of Biotechnology andTherapeutics, Graduate School of
Pharmaceutical Sciences, Osaka
University, Osaka, Japan, (3)Department of Toxicology, Graduate
School of Pharmaceutical Sciences,
Osaka University, Osaka, Japan, (4)Laboratory of PharmaceuticalProteomics, National Institute of
Biomedical Innovation Osaka, Japan,(5) Faculty of PharmaceuticalSciences, Kobe-Gakuin University,
Kobe, Japan.
(1) Department of Hygiene,
Kawasaki Medical School, Kurashiki,
Okayama,Japan, (2) Department of
Molecular Genetics, Division of
Molecular and Clinical Genetics,
Medical Institute of Bioregulation,
Kyushu University, Fukuoka, Japan

Naoko Kumagai，Yasumitsu
Nishimura，Megumi
Maeda，Hiroaki
Hayashi，Takemi

Department of Hygiene, Kawasaki
Medical School, Kurashiki, Japan

Otsuki
Yasumitsu(1) Department of Hygiene,

suppressed expression Nishimura(1), Naokoof NKp46 on NK cells
Kumagai(1), Megumi

Kawasaki Medical School, Kurashiki,Japan, (2) Okayama Rosai Hospital,

exposed to asbestos,
possible predictive

Okayama, Japan

molecular marker for

Maeda(1), Hiroaki
Hayashi(1), Takumi

anti-tumor immune

Kishimoto(2), Takemi

function

Otsuki(1)Development of anallergenicity assay for
genetically modified
animal foods

Nakamura Rika(1),Ryosuke
Nakamura(1),(1) Division of Novel Foods andImmunochemistry, National Instituteof Health Sciences, Tokyo, Japan, (2)Hiroyuki Horiuchi(2),Reiko Teshima(1)Graduate School of Biosphere
Science, Hiroshima University

Tomoko Shindo(1),Murine Food Allergy
Model with Oral

Terumi Katori(1),Yukiko Kanazawa(1),(1) Hatano Research Institute, Foodand Drug Safety Center, Hadano,

Sensitization and Oral
Challenge (7)Motoyasu Ohsawa(1)Kohichi Kojima(1),reiko teshima(2)Japan, (2) National Institute ofHealth Sciences, Tokyo, Japan

Fumitoshi Sakazaki，Parabens enhance

Naoe Chinen，MariMatsuo，Hirofumi

Faculty of Pharmaceutical Sciences,mouse contacthypersensitivity

Ogino，Megumi
Shiroshita，Hitoshi

Setsunan University, Hirakata,Osaka, Japan

Ueno，KatsuhikoNakamuro
Poster Presentations
T-cell Dependent
Antibody Response in
Spontaneously
Hypertensive rat. Effects ofAkihiko Hisatomi，Kiyoshi Kushima，Drug Safety Research Labs. Astellas
Kenji Hoshino，Michio Pharma Inc.

Immunosuppressive
Drugs on Primaly

Fujiwara

Antibody Response Ryota Kawai，○Shiho
Ito，Hiroyuki
Immunotoxicity
evaluation in beagledogs, including T-celldependent antibody
response

Hattori，Tetsuo
Aida，Hidetoshi
Ooshima，Satomi
Komatsu，ToshihikoMakino，Kumi

Medicinal Safety ResearchLaboratories, DAIICHI SANKYO CO.,LTD., Shizuoka, Japan

Honda，Tadashi
Furukawa，Atsushi
Sanbuissho

Relationship between
blood lymphocyte
decrease induced byTakayuki Okamura，Hideki Tokudome，
Makoto Tsunemi，

Toxicological Science Division,

administration stress
Kiyohisa Fukasawa，and CXCR4-mediated T Hideki Harada，Mitsubishi Chemical Medience
Corporation, Kashima, Japan

cell migration incynomolgus monkeys
Effects of toluene
exposure on
developmental
immunotoxicity ininfant mice brain

Yasuyuki Ohnishi，Hideaki Hiratsuka(1)National Institute forTin-Tin Win-Shwe(1),Environmental Studies, (2)NationalNaoki Kunugita(2),Institute of Public Health,Shoji Yamamoto(1),(3)University of Occupational andKeiichi Arashidani(3),Environmental Health, Kitakyushu,
Hidekazu Fujimaki(1)Japan

Effect of Oenothein B

Hideki Matsuoka(1),(1) Division of Novel Foods andon cultured humanMorio Yoshimura(2),Immunochemistry, National Institutedendritic cells

Hiroshi Akiyama(1),of Health Sciences, Tokyo, Japan, (2)Kozue Sakata(1),College of Pharmaceutical Sciences,
Yoshiaki Amakura(2), Matsuyama University, Ehime, Japan
Takashi Yoshida(2),Reiko Teshima(1)Effects of exposure to
low-dose arsenite on
degranulation of mastcell ( 2 )Yuri Shimizu，Seiichiro Himeno

Tokushima Bunri University,Faculty of
Pharmaceutical Sciences,Laboratoryof Molecular Nutrition andToxicoloby,Tokushima,Japan(1) School of Nursing, University of
Shizuoka, Shizuoka, Japan, (2)Research Center for Environmental

Effects of acuteKyoko Hiyoshi(1),inflammation ofshoji Yamamoto(2),Risk, National Institute forEnvironmental Studies, Tsukuba,

Japan, (3) Environmental Healthindigenous bacteria on Ken-ichiro Inoue(3),Sciences Division, National Institutelung asbestosis.
Takamichi Ichinose(4)for Environmental Studies, Tsukuba,
Japan, (4) Department of HealthSciences, Oita University of Nursingand Health Sciences, Oita, Japan
Hiroaki Hayashi(1),Megumi Maeda(1),Immunological effectsof CD4+CD25+T cells
exposed to silica.

Naoko Kumagai(1),Yasumitsu(1) Department of Hygiene,
Kawasaki Medical School, Kurashiki,

Nishimura(1),Japan, (2) Kusaka Hospital, (3)Masayasu Kusaka(2),Uragami Iin

Kouzou Uragami(3),Takemi Otsuki(1)Takemi Otsuki(1),Megumi Maeda(1),Cytokine alteration and Shuko Murakami(1),speculatedNaoko Kumagai(1),immunologicalpathology in silicosis

Hiroaki Hayashi(1),Yoshie Miura(2),and asbestos-related

Yasumitsu

diseases

Nishimura(1),Masayasu Kusaka(3),(1) Dept. Hygiene, Kawasaki Med.
Sch., Kurashiki, Japan, (2) Dept. Mol.
Genet., Med. Inst. Bioregulation,
Kyushu Univ., Fukuoka, Japan, (3)Kusaka Hosp., Bizen, Japan,(4)Okayama Rosai Hops., Okayama,Japan

Takumi Kishimoto(4)Yuichiro Kudo，
Sachiyo Mogi，Yumi

Cytotoxicity study ofKomatsu，Etsuko
high-alumina low-silica
Ohta，Michiyostone wool by cellKoyama，YumikomagnetometricSugiura，Masashi
evaluation
Tsunoda，Yoshiharu

Department of Preventive Medicine
and Public health, Kitasato University
School of Medicine

AizawaEffectiveness of self-Hiroko Nakaoka(1,2), (1) Bioenvironmental Medicine,check software on the

Emiko Todaka(1,2),

website to prevent Sick Masamichi
Building Syndrome
Hanazato(2,3),
Chisato Mori(1,2,4)

Graduate School of Medicine, Chiba
University, Chiba, Japan, (2) Center
for Environment, Health and Field
Sciences, Chiba University, Kashiwa,Chiba, Japan, (3) Department ofArchitecture, Graduate School ofEngineering, Chiba University, Chiba,Japan, (4) Center for PreventiveMedical Science, Chiba University,Chiba, Japan(1) Center for Environment, Healthand Field Sciences, Chiba University,
Kashiwa, Chiba, Japan, (2)The Current Situation
and Treatment of Sick- Emiko Todaka(1,2),

Bioenvironmental Medicine, Graduate

Building Syndrome
Caused by Volatile

Hiroko Nakaoka(1,2), School of Medicine, Chiba University,
Masamichi
Chiba, Japan, (3) Department ofOrganic Compounds

Hanazato(1,3),

Architecture, Graduate School of

Including Flame

Chisato Mori(1,2,4)

Engineering, Chiba University, Chiba,

Retardants

Japan, (4) Center for Preventive
Medical Science, Chiba University,Chiba, Japan(1) Center for Environment, Healthand Field Sciences, Chiba University,
Kashiwa, Chiba, Japan, (2)A Suggestion of Town
Planning to Prevent

Masamichi
Hanazato(1,2),

Department of Architecture,
Graduate School of Engineering,

Adverse Health EffectHiroko Nakaoka(1,3), Chiba University, Chiba, Japan, (3)by Environmental
Chemicals

Emiko Todaka(1,3),
Chisato Mori(1,2,4)

Bioenvironmental Medicine, Graduate
School of Medicine, Chiba University,Chiba, Japan, (4) Center for
Preventive Medical Science, Chiba
University, Chiba, Japan

Luncheon Seminar <1>
Pharmacodynamic
endpoints in theassessment of
immunotoxicity
forbiopharmaceutical

Gregory Bannish

Department of Cell Biology &Immunology, Huntingdon Life
Sciences Inc. (US)development
Luncheon Seminar <2>
Pre-clinical Vaccine
Development andImmune Monitoring

Lawrence Jacob

Charles River Laboratories