The 14th Annual Meeting of JSIT
September 20-21, 2007, Kobe, Japan
President: Shin Yoshino (Kobe Pharmaceutical University)
Special Lecture
Prediction of Hepatotoxicity
using Toxicogenomics Project
Database （TG-GATEs）

Tetsuro Urushidani

Department of
Pathophysiology, Faculty of
Pharmaceutical Sciences,
Doshisha Women's College of
Liberal Arts, Kyotanabe, Kyoto,
Japan /Toxicogenomics/Informatics
Project, National Institute of
Biomedical Innovation, Ibaraki,Osaka, Japan

Invited Lecture 1
Mast cells and KIT receptor
tyrosine kinas

Yunihiko Kitamura

Developmental ResearchLaboratories, Shionogi Co. Ltd.

Edith Sim

Department of Pharmacology,
University of Oxford,UK.

Invited Lecture 2
Drug Induced Allergy
Symposium
Developmental
Immunotoxicology

Organizer Kazuichi
Shionogi Co. Ltd.
Nakamura
KennethL.
Hastings

FDA, USA

Molecular mechanism ofspecific immune system onmaternal decidua

Orie Nakamura

Osaka Medical Center andResearch Institute for Maternaland Child Health, Osaka, Japan

Ontogeny and Post-Nataldevelopment of the rodent
immune system

Hayssam Khali

Charles River Laboratories,
Preclinical Services,
Immunology (CANADA)

Immune system developmentin the primate

Gerhard F.
Weinbauer

Werner Frings, Antje Fuchs,
Eberhard Buse, CovanceLaboratories GmbH

Developmental Immunotoxicity Rodney R. Dietertand Critical Windows ofExposure for Children's Health

Department of Microbiology
and Immunology, Cornell
University, Ithaca, NY 14883
and Director of Developmental
Immunotoxicology, Burleson
Research Technologies,
Morrisville, NC

Regulatory Concerns forDevelopmental
Immunotoxicology

FDA, USAWorkshopKenneth L. Hastings

Issues and Measures ofImmunotoxicologicalOrganizer Jun-ichi
SawadaAssessment

Eiji Maki

National Institute of Health
Sciences
BiosafetyResearchCenter,Foods, Drugs and Pesticides

Pathological considerations ofHiroshi Maeda

TokyoPathologyCenter, Shin

immune system in non-human

Nippon Biomedical

primates

Laboratories, Ltd., Tokyo,
Japan

Introduction and notes ofTakayuki Okamura,

Safety Assessment Division I,

immune function tests inHideki Harada,

Kashima Laboratory, Mitsubishi

monkeys

Yasuyuki Ohnishi

Chemical Safety Institute Ltd.,
Kashima, Japan

Preclinical Safety Assessment

Kiyoshi Kobayashi

Amgen K.K., Tokyo, Japan

Tomoaki Inoue

Safety Assessment Dept., Fuji
Gotemba Research Labs.,
Chugai Pharmaceutical Co.,
Ltd., Japan

Issues in the Development
Process of TGN1412
Points to consider for safety
evaluation of monoclonal
antibody pharmaceuticals

General Session (Oral Presentation)
Evaluation of
immunostimulation by drugs
using mouse popliteal lymph
node response to reporter
antigens

Shiho Ito (1), Tetsuo
Aida (1), Gutting
Bradford Wesley (2),Ryota Kawai (1),
Tadashi Furukawa(1)(1) Medicinal Safety ResearchLaboratories, Daiichi Sankyo
Co. Ltd., Shizuoka, Japan, (2)Naval Surface Warfare Center,
Dahlgren, VA, USA

The role of T lymphocytes intoluene-induced increased
memory-related gene
expressions in the
hippocampus of mice

Tin Tin Win Shwe,
Shoji Yamamoto,
Hidekazu Fujimaki

ResearchCenter for
Environmental Risk, National
Institute for Environmental
Studies, Tsukuba, Japan

Lifestyle affects human NKT
cells

Qing Li (1), Kanehisa (1) Department of Hygiene andMorimoto (2),Public Health, Nippon MedicalTomoyuki Kawada
School, Tokyo, Japan, (2)(1)
Department of Social andEnvironmental Medicine, Osaka
University Graduate School ofMedicine, Osaka, JapanThe effects of fluoride on
cytokine productions ofsplenocytes in the rats afteradministration for two monthin the drinking water

Masashi Tsunoda(1), Sachiko Kimura(1,2), Masayoshi
Tsuji (1,3), YingZhang (1), Chiemi
Sugaya (1), Yoko
Inoue (1),YuichiroKudo (1), Toshihiko
Satoh (1), Hiroshi
Katagiri (4),Kazuyoshi Itai (5),
Yoshiko SugitaKonishi (6),
Yoshiharu Aizawa(1)(1) Department of Preventivve
Medicine and Public Health,Kitasato University School ofMedicine, Sagamihara, Japan,(2) Kanagawa Prefecture Ken-oLivestock Hygiene Station,Atsugi, Japan, (3) Mejiro
University College, Tokyo,Japan, (4) Department of
Public Health, Kitasato
University School of Allied
Health Sciences, Sagamihara,
Japan, (5) Deparment ofPreventive Medicine and Public
Health, Iwate Medical
University School of Medicine,Morioka, Japan, (6) Division ofMicrobiology, National Instituteof Health Sciences, Tokyo,Japan
CYP1A lacalization in immune

Ayako Nakayama(1) Centre for Fish and Wildlife

cells of rainbow trout exposed(1,4), Ivan Riesen

Health, University of Berne,to(1), Elisabeth Eppler Switzerland, (2) Unversity ofbenzo(a)pyreneSegnerHelmut1 (2), Bernd Koellner(3), Kawai
Shin'ichiro (4)Zurich, Switzerland, (3)Friedrich-Loeffler Institute,Insel Riems, Germany, (4)Kobe College, Japan

Gene expression analysis ofRie Yanagisawa (1),murine lungs following

Hirohisa Takano (1), Environmental Studies,(1) National Institute forpulmonary exposure to diesel

Katsura Mizushima

exhaust particles in theabsence or presence ofallergen.

(2), Ken-ichiro Inoue Prefectural University of(3), Kaori Sadakane Medicine, Kyoto, Japan, (3)(3), Toshikazu
Oita University of Nursing andYoshikawa (2)Health Sciences, Oita, Japan

Effect of perinatal exposure ofmaternal rats to brominatedflame retardant HBCD on thedeveloping immune system of
the offspring

Ryosuke Nakamura(1,2), Reiko Teshima(1), Akiko Hachisuka(1), Rika Nakamura(1), Jun-ichi Sawada(1), Makoto
Shibutani (2)(1) Div. Biochem.
Immunochem., Natl. Inst.
Health Sci., Tokyo, Japan, (2)Lab. Verter. Pathol., TokyoUniv.
Agr. Tech., Tokyo, Japan

Effects of in utero throughlactational exposure ofethynylestradiol on immune
system in F1 mice

Hideki Miyaura,
masahiro Takeyoshi

ChemicalsAssessmentCenter,
Chemicals Evaluation andResearch Institute, Japan,Saitama, Japan

Immunization regimen for the Motoko Fukui, Suiji
evaluation of SRBC-specific IgG Shibata, Shigeru
antibody response in a 14 days Hisada
dosing period in rats

Safety Research Department,
ASKA Pharmaceutical Co.,Ltd.,
Kanagawa, Japan

Production of anti-Megumi Maeda (1),(1) Department of Hygiene,

inflammatory cytokines, IL-10
and TGF-b1, in human

Yoshie Miura (2),Kawasaki Medical School,
Yasumitsu Nishimura Kurashiki, Okayama, Japan, (2)polyclonal T cell line exposed
to asbestos(1), Shuko Murakami Eppley Institute for Cancer(1), Hiroaki Hayashi Research, University ofTsukuba, Japan, (2) Kyoto(1), Takashi Nakano(3), Takemi Otsuki

Nebraska Medical Center,Omaha, USA, (3) Department(1)of Respiratory Medicine, Hyogo
College of Medicine,
Nishinomiya, Hyogo, Japan

Effect of laughter on salivary

Masahiro Toda,

Department of Social andendocrinological stress marker
chromogranin A

Kanehisa Morimoto

Environmental Medicine,
OsakaUniversityGraduateSchoolof Medicine, Osaka, Japan

Influence of solvents on skin

Tomoki Fukuyama,

The Institute of Environmental

sensitization assay of metals
with LLNA method

Hideo Ueda, Koichi
Hayashi, Yukari

Toxicology DivisionTajima, Atsuko
Haishima, Hideaki
Fujie, Yutaka
Hayashi, Yasufumi
Shutoh, Tadashi

Kosaka, Takanori
HaradaSynergistic effects ofnanoparticles on respiratory
pathological conditions

Kenichiro Inoue (1),Hirohisa Takano(1,2), Rie(1) Environmental Health
Sciences Division, National
Institute for Environmental

Yanagisawa (1),Miho Sakurai (1),Studies, (2) Inflammation andImmunology, Kyoto PrefecturalTakamichi Ichinose(3), Kaori Sadakane

University of Medicine, (3)Department of Health Science,(3), Toshikazu
Yoshikawa (2)Oita University of Nursing andHealth Science

Effects of indomethacin
administered during late-Kiyoshi Kushima,
Keiko Oda, Shozo

Drug Safety ResearchLaboratories, Astellas Pharma,

gestation on the cytokine
production in rat pups

Sakuma, Michio
FujiwaraOsaka, JapanAn attempt to detect chemicalTomoki Fukuyama,

The Institute of Environmental

allergic reactions using amouse model

Yukari Tajima, Hideo Toxicology Division
Ueda, Koichi
Hayashi, Atsuko
Haishima, Hideaki
Fujie, Yutaka
Hayashi, Yasufumi
Shutoh, Tadashi
Kosaka, Takanori
HaradaMurine Food Allergy Modelwith Oral Sensitization andTomoko Shindo (1),Nami Furuya (1),(1) Hatano Research Institute,
Food and Drug Safety Center,

Oral Challenge (6)Yoshiyuki Tazura (1), Kanagawa, Japan, (2) National
KOhichi Kojima (1), Institute of Health Sciences,reiko Teshima (2)Tokyo, Japan

Changes in salivary
physiological stress markers

Masako Hasegawa,
Masahiro Toda,

Department of Social andEnvironmental Medicine,associated with winning andlosing

Kanehisa Morimoto

OsakaUniversityGraduateSchoolof Medicine, Osaka, Japan

Circadian rhythm of salivary
chromogranin A and stress

Rei Den, MasahiroToda, Kanehisa

The Department of Social andEnvironmental Medicine,

response in male university
students

Morimoto

OsakaUniversityGraduteSchoolof Medicine, Osaka, JapanThe analysis for signal

Yasumitsu Nishimura (1) Dept. of Hygiene, Kawasaki

transduction in the human NK
cell line exposed to asbestos
and cytotoxicity of NK cells(1), Megumi Maeda Medical School, Kurashiki,(1), Shuko Murakami Japan, (2) Eppley Institute for(1), Hiroaki Hayashi Cancer Research, Univ. offrom patients withmesothelioma(1), Yoshie Miura
Nebraska Medical Center,(2), Kazuya Fukuoka Omaha, NE, USA, (3) Dept. of(3), Takashi Nakano(3), Takemi Otsuki

Respiratory Medicine, Hyogo
College of Medicine,(1)

Nishinomiya, Japan

Influence of Restraint stress on Koichi Hayashi (1),(1) The Institute ofimmune system in mice

Environmental Toxicology,(2)Itoh Kanpo Pharmaceutical Co.,

Tadashi Kosaka (1),Tomoki Fukuyama(1), Yukari TajimaLtd(1), Hideo Ueda (1),Satoru Yamaguchi(1), Makio Takeda(1), sayuri Kojima

(1), Yasufumi
Shutoh (1), Toshiaki
Kitazawa (1),Shinichi Maki (1),
Syuichiro Kimura(2), Takanori Harada(1)Analysis of cadmium-induced
cytokine profiles by theMotoyasu Ohsawa,
Kazuko Takahashi

Department of Health Sciences,
Faculty of Pharmaceuticalantibody microarray ofcytokines

Sciences, TeikyoUniversity,
Sagamihara, Japan

Enhancement of IgEKouya Yamaki, Shindependent allergic reactions in YoshinoDepartment of Pharmacology,
KobePharmaceuticalUniversity,

vivo and degranulation of mast
cells in vitro by butylated

Kobe, Japan

hydroxytoluene （BHT）
General Session (Poster Presentation)
Immunotoxicity evaluation of
methotrexate in rats byintermittent dosing for two

Ryota Kawai, Tetsuo
Aida, Shiho Ito,satomi Komatsu,

weeks

Shinya Sehata,
atsuko Muramatsu,

Medicinal Safety ResearchLaboratories, Daiichi SankyoCo., Ltd.

Tadashi Furukawa,Sunao Manabe
Effects of airway exposure todiesel exhaust particles on

Kenichiro Inoue (1),Hirohisa Takano(1) National Institute forEnvironmental Studies, (2)atopic mice(1,4),RieYanagisawa (1),OitaUniversity of Nursing andHealth Science, (3) University

Takamichi Ichinoseof Tottori, (4) Kyoto Prefectural(2,) Akinori Shimada University of Medicine(3), Toshikazu
Yoshikawa (4)Cytokine productions ofvarious cell types by

Kazuhiko Takahara(1), Takefumi Ikeda(1) Lab. of Immunobiol., Dep.
of Animal Development andnanomaterials in comparison
with asbestos(1), Kohei Mizuno(2), Kunio Uchida

Physiol., Grad. Sch. of
Biostudies, Kyoto University.,(2), Kazuhiro
Yamamoto (2),(2) Advance Industrial Scienceand Technology

Hajime Kawasaki(2), Kayo Inaba (1)Effect of prenatal and
Shoji Yamamoto,postnatal exposure to low-level Atsushi Fukushima,

ResearchCenter for
Environmental Risk, National

toluene and peptidoglycan on Tin Tin Win Shwe,systemic Th1/Th2 immunity in Rieko Hojo,

Institute for Environmental
Studies, Tsukuba, Japan

infant mice

Hidekazu Fujimaki

Effect of exposure to carbon
black nanoparticles on thematuration and the accessory

Eiko Koike(1),(1) Environmental Health
Hirohisa Takano (1), Sciences Division, National
Ken-Ichiro Inoue
Institute for Environmental

activity of mouse bonemarrow-derived dendritic cells(1), Rie Yanagisawa(1), TakahiroStudies, Tsukuba, Japan, (2)Integrated Research Institute,Kobayashi (2)Tokyo Institute of Technology,
Yokohama, Japan

Effects of titanium dioxide

Tomoko Kamachi(1) Graduate Shool of(TiO2) nanoparticles on atopic(1,2), Hirohisa

Environmental Sciences,dermatitis-like skin disorders

Takano (2,4), Rie

University of Tsukuba,

Yanagisawa (2),
Kenichiro Inoue (2),Tsukuba, Japan, (2) National
Institute for Environmental

Eiko Koike (2),Takamichi Ichinose(3), Kaori SadakaneStudies, Tsukuba, Japan, (3)Oita University of Nursing andHealth Sciences, Oita, Japan,(3), Toshikazu
Yoshikawa (4)(4) Kyoto Prefectural Universityof Medicine, Kyoto, Japan

Gene expression analysis forTakako Hamano,

Toxicology Laboratory,

hyperglycemia induced by
glucocorticoids

Toshinobu Shimizu,
Naohisa Tsutsui

Mitsubishi Pharma Corporation,Chiba, Japan

Cross-talk between theKazutake Tsujikawa,

Department of Immunology,

nervous and immune systems
through calcitonin gene-

Yusuke Ogitani,
Ippei Otani, Emi

GraduateSchool ofPharmaceutical Sciences,

related peptide

Hirayama, KeikoOsakaUniversity

Watanabe, Hiroshi
Yamamoto
Immixture of chronicallyHiroaki Hayashi (1),(1) Department of Hygiene,

activated T cells and surface
Fas expression in peripheral

Yoshie Miura (2),Megumi Maeda (1),

Kawasaki Medical School,
Kurasiki, Japan, (2) Eppley

CD4+25+ T cell fraction inShuko Murakami (1), Institute for Cancer Research,silicosis patients.HAYASHI

Yasumitsu Nishimura University of Nebraska Medical

HIROAKI1,(1), Masayasu
Kusaka (3), Takemi

Center, Omaha, U.S.A, (3)Kusaka Hospital, Bizen, Japan

Otsuki (1)Effects of exposure toelectromagnetic fields on

Yuichi Miyakoshi,
Hidesuke Shimizu,

Department of public healthand environmental medicine,genotoxicity in rat astrocytes - Hiroyuki Yanagisawa The Jikei University school ofapplication for immunotoxicity-

medicine, Tokyo, JapanThe effect of plant oil on oral

Reiko Teshima,

National Institute of Healthsensitization of food allergen,

Haruyo Okunuki,

Sciences

ovomucoid in mice

Ryosuke Nakamura,
Yuji Sato, Hiroshi
Akiyama, Jun-Ichi
SawadaStudy for evaluation of

Shinji Utsunomiya,

Drug Safety Research

phototoxicty by oral

Yoshihiro Takahashi,Laboratories, Shin Nippon

administration in BALB/c mice

Yasuhiro Tanaka,
Kaori Kumano,

Biomedical Laboratories, Ltd.,
Kagoshima, Japan

Takahiro Nakamura,
Hiroyuki Izumi,
Hiroshi Tokado
Analysis of Mechanism on

Ken-Ichi Tomiyama,

Department of Hygiene &Organotin-Induced Cell Death Takao Kuriyama,of T-Lymphocytesin an sight of Akiko Yamaguchi,

Preventive Medicine, Faculty ofHealth Sciences, The University

the difference in its chemical

Yurie Sayama, Yokoof Shizuoka, Shizuoka 422-structure

Echizenya, Megumi

8526, JapanNakata, Nami
Watanabe, Yasuaki
Arakawa
Induction of Interleukin-6 andSeiichiro Himeno(1) Faculty of Pharmaceutical

metallothionein by metal(1), Hitomi FujishiroSciences, Tokushima Bunricompounds(1), Jiaming Yu (1),University, Tokushima, Japan,

Kazuo Kobayashi(2), Tatsuya(2) Kissei Pharmaceutical Co.,
Ltd., Nagano, Japan, (3)Hasegawa (3),
Yoshiyuki Seko (3)Yamanashi Institute ofEnvironmental Sciences,
Yamanashi, Japan

Induction of autoimmune
arthritis in mice induced byTakayuki Saito,
Kouya Yamaki, Shin

Department of Pharmacology,
KobePharmaceuticalUniversity,

anti-type II collagenYoshinoHyogo, Japan

Wing Mark

Huntingdon Life Sciences Ltd.,
Immunology and Cell Biology

Jacob LawrenceCharles River Laboratories

monoclonal antibodies
Luncheon Seminar 1
Applications for cell based
assays in biopharmaceuticaldevelopment - from batch
release & stability toassessment of neutralising
antibodies
Luncheon Seminar 2
ImmunoToxicogenomics Potential for the use of
immunogenomics in preclincal
toxicity assessment ofpharmaceuticals

Preclinical Services Edinburgh,
Edinburgh, Scotland, UK