E-Catalog Version 19.0

ChemGenes Corporation is now ISO 9001:2008 Certified Company

Bio Technology
Manufacturer of

Products &DNA-RNAIntermediates

Product Highlight
Extensive Product Lines: DNA amidites: Bulk Quantities for therapeutics grade oligo synthesis
 Natural and modified DNA amidites Natural & modified RNA amidites : Bulk Quantities
 2’-O-Methyl amidites: Bulk Quantities RNA Synthesis in Reverse Direction
 TOM amidites for RNA synthesis : Bulk Quantities
 2’-O-ALE amidites
 2’-O-PivOM amidites
 2’-Fluoro amidites
 Non-Cleavable Inert Supports
 ETT & BMT : Bulk Quantities
 DDTT Sulfurizing Reagent
 UnyLinker Universal Support
 Akta Oligonucleotide Synthesizer Reagents
 N-Alkylated nucleosides and amidites
 5-Azacytidine and 5-Aza-2’-deoxycytidine
 Thio uridines & thymidines nucleosides and amidites
 6 & 5-FAM NHS Esters
 6 & 5-FAM-(C-6 linker) amidites
 Biotin (BB)-(urea nitrogen protected) Supports & amidites
 Polyethylene glycol (PEG) (MW. 2000 and 4500) amidites
 5’-MMTr nucleoside amidites (Purines: A & G) 8-Methyl dG & rG amidites
 8-Oxo dA & dG amidites
 5’-O-Methyl DNA amidites
 Fmoc Protected Nucleoside amidites
 5-Formyl dU amidites
 Ammonia Free Deprotection Reagents
 Thiol modifiers (acyclic and cyclic) DNA and RNA Purification kit
Toll Free: (800) 762-9323
Toll Free:(800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

www.chemgenes.com
Email: info@chemgenes.com

Experience Nucleic Acid Expertise

Since 1981, the products and services provided by ChemGenes Corporation continue
to accelerate the pace of DNA/RNA oligonucleotide synthesis, research, and development in the pharmaceutical and biotechnology industry.

33 Industrial Way
Wilmington, MA 01887
Call: 978-694-4500, Toll Free: 800-762-9323
Fax: 978-694-4502
Email: info@chemgenes.com
Visit us at: www.chemgenes.com

www.chemgenes.com
Email: info@chemgenes.com

ChemGenes Corporation
Background
ChemGenes Corporation, a biotechnology company located in Wilmington, Massachusetts, hasbeen a strong partner to researchers engaged in the field of DNA/RNA synthesis for more than 20
years. By starting out as a supplier of ‘Ultra Pure Products’ and then also by becoming an active
Contract Researcher, ChemGenes Corporation has achieved unparalleled expertise in the field of
DNA/RNA synthesis. Thus, all of us at ChemGenes have the opportunity and great pleasure to servea vast number of scientists in the US and all over the world.
ChemGenes helds a number of patents in the field of standard, modified, as well as backbone
modified DNA/RNA synthesis products. ChemGenes has a worldwide licensing agreement on US
patent No.s 4,415,732 and 4,458,066, pioneering patents on the discovery of DNA and RNA synthesis by Caruthers and Beaucage. We had another worldwide licensing agreement on US patent
No. Re 34,069, the presently popular cyanoethyl (CEP) phosphoramidite version for DNA and RNA
synthesis.
ChemGenes product lines include phosphoramidites for DNA and RNA synthesis, Antisense phosphoramidites, modified bases for DNA, as well as RNA modification. In addition, we produce a variety of modified phosphoramidites for the introduction of chromophores and ligands. The availabilityof prepacked disposable columns of various pore sizes, loadings, low volume columns, ancillary
reagents in configurations suitable for each synthesizer, and DNA purification cartridges is another
way ChemGenes meets its customers’ needs.
ChemGenes has a strong, dedicated, and talented team of professionals for the manufacturing ofmany natural and modified nucleoside bases. Included in these natural and modified bases are
DMTr protected deoxy and ribo nucleosides, 2’-O-methyl and 2’-O-propargyl nucleosides, and silyl
protected ribonucleosides.
A large variety of reagents for the synthesis of DNA/RNA are also available. These include 5-thioethyltetrazole (ETT), benzylthiotetrazole (BTT/BMT), DMTr-chloride, MMTr-chloride, and several types ofphosphorylating reagents such as cyanoethyl chloro phosphitylating reagent, cyanoethyl tetra isopropyl phosphitylating reagent, cyanoethyl dichloro phosphitylating reagent and 5’, 3’-bis silylating
reagent.
As the market for oligonucleotides continues to grow, ChemGenes will stay committed to introducing novel products, while maintaining its existing product mix. We also have the capacity to custom
synthesize products on request. Our highly trained technical staff is always available and happy
to help you with your special needs and demands in this area. For information regarding the fullrange of products and their applications, please call us at 978-694-4500 or toll-free 800-762-9323,
fax: 978-694-4502, or e-mail: info@chemgenes.com

iToll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Special Gratitude
The nucleoside phosphoramidites available in this catalog are the result of the classical research contribution by Professor M.H. Caruthers and colleagues (University of Colorado, Boulder, CO) (Beaucage S. L.;
Caruthers, M. H. Tet. Lett., 1981, 22,1859-1862). Other enormous contributions in this field have been madeby Professor K.K. Ogilvie and colleagues (Acadia University, Acadia, Canada), Professor R.L. Letsinger and colleagues (Northwestern University, Evanston, IL), and Professor H. G. Khorana, Noble Laureate and colleagues(Massachusetts Institute of Technology, Cambridge, MA).

Patents, Licensing & Trademarks
Patent & Application Number
7956169

Title of Patent

Date Issued

Synthesis of novel azo-dyes and their use in oligonucleotide synthesis

June 7, 2011

The invention provides a novel group of azo quencher compositions that are useful as quenchers of fluorescence and tomethods for making and using them. The quenchers contain an azo bond and 1,3,3-trimethyl-2-methyleneindoline ringsystem. The quenchers can be derivatized to facilitate their conjugation to a variety of biologically relevant compounds,
including lipids, nucleic acids, peptides, proteins, and the like.

7846436

Oligonucleotides and related compounds

December 7, 2010

The present invention relates generally to oligonucleotides and more specifically to oligonucleotides which have a sequence including at least two CpG dinucleotides and a prodrug of an antimetabolite. The prodrug can be part of a CpG
dinucleotide or may be attached elsewhere on the oligonucleotide.

9493773

Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides

App# CA2880496
Nov 15, 2016
App#CN104812770
App# EP2882769
App# WO2014022566
The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined
se-quences which can exhibit biochemically useful and biologically valuable properties, thus having potential fortherapeutic uses.

9718855

Nucleosides and oligonucleotides for studies on reversal of cytotoxic and mutagenic damageof DNA and as diagnosticstools
Aug 1, 2016

The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides
that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools.

App# CA2924186

Long RNA, Highly efficient synthesis of long RNA using Reverse
Direction ApproachApp# CN105916873
Oct 29, 2015
App# WO2015039053
The present invention relates to novel process of reverse 5 ' 3 ' directed synthesis of RNA oligomers in the range of about
100-mer to about 200-mer has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.
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ChemGenes Corporation
9884885

Synthesis of labile base protected - modified deoxy & modified ribo nucleosides, corresonding phosphoramidites and supports and their use in highMar 15,2012
purity oligonucleotide synthesis

This invention relates to novel method of synthesis of RNA utilizing N-2-acetyl protected guanine as nucleoside base,nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides
and RNA oligonucleotide synthesis. Our discovery using N-acetyl protected guanine as nucleoside base protecting
group, which is significantly faster base labile protecting group, yet significantly more stable than commonly utilized-2-isobutyryl guanosine is a novel approach to obtain highest purity oligonucleotides. This approach is designed tolead to very high purity and very clean oligonucleotide, after efficient removal of the protecting groups, including acetyl group from guanine and to produce high purity therapeutic grade DNA oligonucleotides, RNA oligonucleotides,
diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of acetyl protecting groups of the natural
deoxy and ribonu-cleosides occurs under substantially reduced time in contact with mild deprotection conditions
such as mild bases, sec-ondary amines for removal of such groups under such conditions would allows synthesis ofvarious DNA and RNA of highest purity for diagnostics and therapeutic application. This approach is designed to leadto high purity large.

9605261

RNA synthesis—phosphoramidites for synthetic RNA in the reverse direction,

8541569

Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3’-end ligands, chromophores and modification of synthetic RNA
Sep 24,2013

App#EP2326656
and application in convenient introduction of ligands, chromophores andApp# CA2735251
modifications of synthetic RNA at the 3’-end
Mar 28,2017
App# CN102439025
The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an
HPLC purity of greater than 98% and 31P NMR purity greater than 99%. A novel process of reverse 5'
3'directedsynthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA
synthesis with coupling efficiency approaching 99%

The present invention provides building blocks and methods for synthesizing very pure RNA in a form that can efficiently be modified at the 3'-end. Reverse RNA monomer phosphoramidites have been developed for RNA synthesis in
5'
3' direction, leading to very clean oligo synthesis that allows for the introduction of various modifications at the
3'-end cleanly and efficiently. Higher coupling efficiency per step have been observed during automated oligo synthesis with the reverse RNA amidites disclosed herein, resulting in a greater ability to achieve higher purity and produce
very long oligonucleotides. The use of the reverse RNA phosphoramidites in the synthetic process of this invention
leads to oligo-nucleotides free of N+1 species.

8530634

Oligonucleotide Labeling-Cycloaddition Reaction (Method of oligonucleotide labeling using
cycloaddition reaction
Sep 10,2013

The invention provides a novel method of labeling oligonucleotides, with reporter moieties, including but not limited
to, quenchers, fluorophores, biotin, digoxigenin, peptides and proteins. In addition, this invention provides a methodof de-tecting hybridization of oligonucleotides. This invention also provides novel azo quenchers having the generalformula shown below. The invention further provides compositions comprising labeled oligonucleotides and solid supports. The invention also provides kits comprising at least one composition of the present invention.

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9441002

Dithiolane based thiol modifier (Dithiolane based thiol modifier for labeling and stronger
immobilization of bio-molecules on solid surfaces
Sep 13,2016

The thiol modified oligonucleotides have vast number of applications in the field of nucleic acid chemistry. The conjugates generated by mono thiol groups are unstable at higher temperature, in high salt concentration buffers and inpres-ence other thiols. There is strong need to develop a novel thiol modifier probes that can generate multiple thiolgroups. Described herein are efficient processes and compounds, dithiolane phosphoramidites derivative and dithiolane succinyl supports. The advantage of our cyclic disulfide thiol modifier is multifold a) each incorporation introduces
two thiol groups; b) it can be introduced at any desired site of oligonucleotides; c) The symmetrical branching nature of
the spacer in the linker arm of dithiolane allows for clean oligo synthesis, where cleavage of the linker arm and therebyof loss of oligo chain is prevented. We have successfully made 20-mer oligonucleotide containing single dithiolane
derivative at 3', and 21-mer oligonucleotides containing single dithiolane derivative at 5′ or in the middle of the mixedbase sequence. HPLC and ESI MS analysis of these oligonucleotides indicated satisfactory purity and correct composition of these oli-gos, respectively.

7932287

Therapeutic compositions and uses

8389577

Method of treating a human being for a class of metabolic defects and energy production
disordersMar 5, 2013

April 26, 2011

The invention provides compositions for and methods of treating a number of disorders. In one embodiment, theinven-tion provides a method of treating a wide range of conditions by administering to a human being in need ofsuch treat-ment, a therapeutically effective amount of (a) N-6-trimethyl-L-lysine of at least 98% purity, (b) a prodrug
thereof, (c) an aliphatic chain derivative thereof, (d) an ester derivative thereof, (e) an amide derivative thereof, or (f ) a
pharmaceutically acceptable salt of said N-6-trimethyl-L-lysine or said prodrug.

The invention involves various embodiments of a method for treating a human being for a condition associated with
(1) a clinical state of impairment of carnitine or carnitine esters, or decreased fatty acid metabolism, (2) low energy
production or lower ATP production, (3) clinical hyperammonemia, and (4) clinically high pyruvate levels resulting froma deficiency in the biosynthesis of carnitine. The method involves administering a therapeutically effective salt of N-6trimethyl-L-lysine.

8518992

Method of synthesis and purification of N-6-trimethyl-L-lysine and derivative compounds
Aug 27, 2013

The invention provides a method of synthesis of N-6-trimethyl-L-lysine (TML) derivative compounds for potential treatment of disorders resulting from deficiencies in the TML-carnitine pathway. The invention also provides a method ofpuri-fication of TML and TML derivative compounds. The treatment of conditions of the diseases late infantile neuronal ceroid lipofuscinosis (LINCL) and neuronal ceroid lipofuscinosis (NCL) with TML were shown in the original parent
application.

8778996

Method of treating a human being for a class of neurological defects and seizure disorders
Jul 15, 2014

The invention involves various embodiments of a method for treating a human being for a condition associated with
(1) seizures, myoclonic seizures, epilepsy, refractory epilepsy, hyperkinetic movements or tremors of hands or feet, (2)a state of ataxia, (3) accumulation of neuronal autofluorescent storage bodies in lysosomes or neurons, or regressionof motor development, and (4) low alertness, dementia or mental retardation. The method involves administering atherapeu-tically effective salt of N-6-trimethyl-L-lysine.

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ChemGenes Corporation
8981076
App#WO2010062404

Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides,modified
deoxy and ribo nucleosides, and phosphoramidites, and their use inoligonucleotide synthesis
Mar 17, 2015

This invention relates to synthesis of novel -N-FMOC protected nucleosides, succinates, phosphoramidites, corresponding solid supports that are suitable for oligo deoxy nucleosides and RNA oligonucleotide synthesis. Our discovery using
N-FMOC as nucleoside base protecting group, which is highly base labile protecting group is a novel approach to obtainhighest purity oligonucleotides. This approach is designed to lead to very high purity and very clean oligonucleotide,
after efficient removal of the protecting groups and to produce high purity therapeutic grade DNA oligonucleotides,
RNA oligonucleotides, diagnostic DNA, diagnostic RNA for microarray platform. The deprotection of FMOC protecting
groups of the natural deoxy and ribonucleosides occurs under very mild deprotection conditions such as mild bases,
secondary and tertiary amines for removal of such groups under such conditions would allows synthesis of various DNA
and RNA of highest purity for diagnostics and therapeutic application. This approach is further designed to use FMOC
protecting group on various base sensitive nucleoside, and for use in oligo peptide synthesis and for support boundoligo nucleo-tides. DNA oligonucleotides containing 3'-end dA at the 3'-terminal will be produced using the FMOC-dAsupports would lead to much reduced M−1 deletion sequences, and thereby high purity.

App# US20150018579
App# WO2013126034

Synthesis of high purity DMT-C3-disulfide phosphoramidite

Jan 15, 2015

The 5' and 3'-thiol modified oligonucleotides are attractive tools with a vast number of potential applications in thefield of nucleic acid chemistry. There is a strong interest in developing new disulfide compounds or to optimize synthesis of existing disulfide modifiers, which are efficient in generating the 3'- or 5'-end reactive thiol group. Various synthetic pro-tocols have been employed to synthesize pure 3-((3-(bis(4-dimethoxytrityl)propyl)di-sulfanyl)propyl 2-cyanoethyl diiso-propylphosphoramidite (compound 2) starting from 3-(dimethoxytrityl)propyl)disulfanyl)pro-pan-1-ol,(compound 1). Here-in, we describe an efficient, reproducible synthetic and purification protocol for target compound
2 from the compound 1. It is noteworthy that our reaction conditions were reproducible even at multi-gram scale (27g) with a purity level as achieved in a small scale.

US8618279B2 Synthesis of 2', 3'— and 3', 5'—cyclic phosphate mono-and oligonucleotides Jan 12, 2011

The invention provides a novel method for the chemical synthesis of 2',3'-cyclic phosphate and phosphorothioate ofmono and terminated oligonucleotides synthesis. The invention also provides a novel method of for the chemical synthesis of 2', 3'- and 3', 5'-cyclic phosphate and phosphorothioate mononucleotide nucleotides. The process is basedon quick and efficient cyclization of phosphoramidate moiety and neighboring hydroxyl group. The present invention
is directed towards the synthesis of high purity DNA and RNAs, specifically to introduce cyclic phosphate at 3'-endof oligo-nucleotides. Such DNA and RNA's have extensive application in therapeutics, diagnostics, drug design, andselective inhibition of an RNA sequence within cellular environment, in pre-tRNA cleavage and in ribozyme ligation.
The 2',3'-cyclic phosphate nucleosides are involved in a vast number of applications in molecular biology in generaland mammalian cells in particular. The invention also envisions providing kits comprising at least one composition
disclosed in the pre-sent invention.

Previously Issued Patent:
5744595

Propargyl modified nucleosides and nucleotides

April 28, 1998

The present invention describes a novel 2'-O-alkylation reaction to produce a novel series of nucleosides carrying
the 2'-O-propargyl group, using propargyl bromide, dibutyl tin oxide and tetrabutyl ammonium bromide. The procedure involves novel techniques for regioselective introduction of 2'-/3'-O-propargyl group directly on the 5'-DMT-Nprotected- nucleo-sides using dibutyl tin oxide as a mild base in conjunction with a phase transfer catalyst, tetrabutyl
ammonium bromide. The reaction process has many significant features and leads to isomeric ratios in favor of the2'-regio isomer. This al-lows the synthesis of the corresponding phosphoramidites of high purity.
v

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N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and theirphosphoramidite derivatives
June 11,1996

5525719

This invention is directed to processes for producing high purity N-protected-2'-O-methyl-5'-dimethoxytrityl-3' ribonucleo-side methoxy, N,N-diisopropyl phosphoramidites (group 1), and N-protected-2'-O-methyl-5'-dimethoxytrityl3'-ribonucleoside ethoxy, N,N-diisopropyl phosphoramidites (group 2). This invention is further directed to theprocess for producing high purity 2'-O-methyl-5'-dimethoxytrityl-inosine (structure IX; group 3), and 2'-O-methyl-5'dimethoxytrityl-inosine-3'-cyanoethyl, N,N-diisopropyl phosphoramidite (structure Xa; group 3). This invention is also
directed to the pro-cess for producing high purity N-protected-3'-O-methyl-5'-dimethoxytrityl ribonucleosides (group6), and N-protected-3'-O-methyl-5'-dimethoxytrityl-2'-ribonucleoside cyanoethyl, N,N-diisopropyl phosporamidites(group 7).

5214135

N-protected-2'-O-methyl-ribonucleosides and N-protected 2'-O-methyl-3'-cyanoethyl-N-,NMay 25, 1993
diisppropyl phosphoramidite ribonucleosides

This invention is directed to N (amino)-protected-2'-O-methyl (methoxy)-5'-dimethoxytrityl (dimethoxytrityl) ribonucleo-sides (Group I compounds) and to N-protected-2'-O-methyl-5'-dimethoxytrityl-3'-ribonucleoside cyanoethyl N,Ndiisopropyl phosphoramidites (Group II compounds). This invention is further directed to the processes involved in
pro-ducing these compounds. The purification processes produce products in Group I with purity in excess of 99.50%
and up to 99.8%. The purity of the products in Group II ranges in excess of 99.8% and up to 99.9%.

6015886

2’-O-Methyl, Ethyl phosphoramidite, (Oligonucleotide phosphate esters)

Jan 18, 2000

This invention relates to synthetic oligonucleotides that are useful for antisense based therapeutic applications. The
syn-thetic oligonucleotides of this invention have modifications in the sugar phosphate backbone for improved antisense properties.

Licensed Patents:
TOM Amidites, ChemGenes Corp. holds worldwide license of Patent# 5986084,
from Qiagen Inc.
ssR amino linker, ChemGenes Corp. holds worldwide license of Patent# 7491857 B2.
NIAIST & DNA Chip Research, Japan
2’-O-ALE-5’-NPPOC amidites, ChemGenes Corp. holds worldwide license of Patent# 025566 A1 from McGill
University and Wisconsin Alumni Research Foundation.
Unylinker Support TM, ChemGenes Corp. holds worldwide license of Patent# US7202264; Isis Pharmaceuticals,Inc.
2’-O-Pivaloyloxymethyl(PivOM) Patent, ChemGenes Corp. holds worldwide license of Patent# 2009144418,
Debart, F; Vasseur, J.-J; Lavergne, T. “Process for the solid phase synthesis of RNA”.

vi

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Tools for Molecular Biology Research
Natural DNA Amidites, Supports & Oligo Synthesis ReagentsStandard base protection-DNA amidites

3Standard base protection-DNA supports

4

Mild base protection-DNA amidites

5

Mild base protection-DNA supports

6

Fast deprotection (Using AMA reagent)-DNA amidites

7

Base unprotected-DNA amidites

7

Methyl phosphoramidites

8

Benzyl phosphoramidites

9

Reverse DNA synthesis

10

Supports for reverse DNA synthesis

10

Polystyrene Supportsfor reverse DNA synthesis

11

Levulinyl amidites & levulinyl deprotection solution

12

DNA Dimers

13

DNA H-Phosphonate monomers

14

Succinyl Polystyrene Supports

15

Non-cleavable supports

16

Unylinker supports

17

lcaa Amino supports

18

Empty columns, Filters

18

Ancillary Reagents For Automated Oligonucleotide Synthesizer

19-25(ABI, Akta, Expedite, MerMade Oligonucleotide synthesizers)

Modified DNA Amidites and Supports
2-Thio-dU, 2-Thio-T, 4-Thio-T, 4-Thio-dU amidites & supports

27

dI, dU, 5-Methyl-dC amidites & supports

28

α-D-Amidites & supports, 5-Methyl-α-D-dC amidites

29-30

2'-O-TFA-propyl-dU & dC, 3'-TFA-Amino-dC & dU, 3'-Amino-dT, 5'-Amino-dT modifications & Support for 5'-Amino-dT modification

31

Ara nucleoside amidites & supports

32

7-Deaza-dI, 7-Deaza-dA, 7-Deaza-dG amidites & supports

33

7-Deaza-7-iodo-dA & dG amidites, 7-Deaza-7-propargylamino-TFA-dA & dG amidites

34

Cordecypin (3'-dA) amidite & supports, 6-Thio-dG amidite

35

Halogenated nucleoside amidites & supports

36-37

N-Alkylated nucleoside amidites & supports

38-39

O -Trimethyl-silyl-ethoxy-dI, O -Diphenylcarbamoyl-dG & Modified purine amidites

40

8-Methyl-dG amidites & supports

41

Modified purine 2’-deoxy riboside amidites & supports

42

Triazolyl-dU & dT-amidites, Iso-dG & dC-amidites, supports for Iso-dC & dG

43

L-DNA (Mirror Image) amidites & supports, 5-Formyl-dU

45-46

Abasic amidite, Reverse abasic amidite & supports, 8-Oxo-dA & dG amidites & supports

47

Dideoxy amidites and supports

48

5'-O-Methyl DNA amidites, DNA 3',5'-Diamidites & Thymidine 3'-Bis (diisopropylamino)-phosphoramidite

49-50

DNA purification kit

51

DNA purification drying traps

52

DNA purification cartridges and barrels

53-54

6

6

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Natural RNA Amidites and Supports
Standard base protection-RNA amidites

57

Supports for RNA synthesis (Standard base protection)

58

Labile base protection-RNA amidites

59

Supports for RNA synthesis (Mild base protection)

60

Oxalyl RNA supports and Ammonia free oligo deprotection solution

61

2'-O-ALE amidites

622'-O-Pivom amidites

63

3'-Polystyrene Supports for RNA synthesis

64

RNA methyl phosphoramidites

65

Labile base protection RNA Methyl phosphoramidites

66

Reverse RNA synthesis and supports

67

Tom amidites and supports

69

Modified RNA Amidites and Supports
2'-5'-Linkage RNA amidites

72

N -Substituted RNA amidites and supports, 8-Methyl-rG RNA amidite & supports

73

5-Methyl-rC, rT, rI, Anhydro-rU RNA amidites & supports74

3

N & N -Substituted ribo nucleoside amidites & supports

75

4-Thio-rU, 4-Triazolyl-rU, Modified pyrimidines, purines, Pseudo uridine amidites & supports, Puromycin supports

76

2'-Fluoro RNA synthesis & supports, Modified 2'-Fluoro (5-methyl-dC & dU, 5-iodo-dU & dI) RNA synthesis, Reverse 2’-F amidites

77-80

Modified purine amidites & supports

81

2'-Amino-TFA-rC & rU amidites & supports, 5'-Amino-TFA-rC amidites

82

7-Deaza amidites & supports, 7-Deaza-7-cyano & reverse 7-Deaza-rG amidites

83

Halogenated ribo amidites & supports, 8-Oxo-rG & 8-Oxo-7-allyl-7,8-dihydro-rG amidites

84-85

Iso-rC, Iso-rG amidites & supports

86

Diacetyl rU & rG, 5,6-dihydro-rU amidites

87

L-RNA (Mirror Image) amidites & supports

88

Ethyl RNA phosphoramidites

89

RNA Purification kit

90-92

6

4

2'-O-Alkyl/Antisense Oligonucleotide Modifications
2'-O-Methyl-RNA amidites

932'-O-Methyl-RNA supports

94

2'-O-Methyl-RNA amidites (mild protection) & supports

95

2'-O-Methyl-5-methyl-(rC & rU), 2'-O-Methyl-rI, rT & 2’-O-Methyl-modified purine amidites

962’-O-Methyl-5-Propynyl-rC & rU, Amino Modifier 2’-O-Methyl (rC & rU), 2’-O-Methyl-4-Triazolyl-rU

97

Halogenated 2'-O-Methyl rU amidites & Modifier 2’-O-Methyl supports

982’-O-Methyl-7-Deaza rA & rG, 2’-O-Methyl-7-iodo-7-deaza rA & rG & 2’-O-Methyl-7-deaza-7-propargyl rA & rG Amidites

99

2’-O-Methyl-3'-ethyl phosphoramidites

1002’-O-Methyl-3'-ethyl phosphoramidites (Mild base protection)101

3'-O-Methyl amidites & supports

102

2'-Deoxy 3’-ethyl phosphoramidites

103

3'-Oxalyl supports, Ammonia free oligo deprotection solution

104

DNA 3’-Methyl Phosphonamidites

105

2’-O-Methyl-3'-Methyl Phosphonamidites

106

Labile 2'-deoxy 3’-methyl phosphoramidites & 2'-deoxy 3’-isopropyl phosphoramidites

107

2’-O-(2-Butynyl) RNA amidites & supports

108

Reverse 2'-O-Methyl amidites, Reverse 2'-O-Methyl-5-methyl-(C & U) & supports

109-110Ara-2'-O-methyl amidites & supports

111

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Tools for Molecular Biology Research
CombiClickTM Chemistry Products2’-O-Propargyl amidites & supports

112

3’-O-Propargyl amidites & supports

113

Abasic 2'-O-Propargyl amidite & Supports, Ara-2'-O-propargyl I

114

2’-O-Hexynyl inosine & Abasic 2'-O-Hexynyl amidites

115

Chromophores and Ligands
Phosphate introducing reagents & supports

117

Amino modifiers, CPG & Polystyrene Supports

118-122

Spacer modifiers, CPG & Polystyrene Supports, Palmitoyl Polystyrene Supports

123-125

Thiol modifiers & supports (acylic an cyclic)

125-127

Biotin labelling & supports

128

Branching phosphoramidites & supports, Levulinyl deprotection solution

129

Carboxyl generating reagents, Aldehyde generating reagent

130(+)-a-Tocopherol-Phosphoramidite

131

Cholesterol amidites & supports

132

Dabcyl labelling & supports, DNP labelling & supports

133

Fluorescein labelling: Etheno dA & dC amidites & supports

134

Fluorescein labelling: HEX, TET, 6-FAM & HEX (Cyc) & TET (Cyc) amidites

135

Fluorescein labelling: 5-Fluoroscein, 5-Fluoroscein dT amidites & supports

136

Fluorescein labelling: DMTr 5 & 6 FAM & supports

137

Fluorescein labelling: Rhodamine (Tamra) amidites & supports

138

Psoralen labelling & supports,

139-140

Puromycin Labelling & supports (Refer page 74)

Nucleosides
Nucleosides (Base N-Unprotected)
Deoxy nucleosides

141

Dideoxy nucleosides, 7-Deaza-7-iodo-dideoxy-(A & G) 5-Iodo-dideoxy-(C & U), 7-Deaza-dideoxy-(A & G)

142

dU, dI, 8-Oxo-dG , Etheno-(dA & dC), 5-Methyl-dC

143

Modified deoxy nucleosides: 5-Bromo-(dC & dU), 8-Bromo-(dA & dG) & 5-Iodo-(dC & dU)

144

Modified deoxy nucleosides: N-alkylated

145

Modified deoxy nucleosides: 4-Thio-(dU & T), 6-Thio-dG, O -Carboxymethyl-dG & 5-Propynyl-(dC & dU)

146

6

L-Deoxy, a-D-deoxy nucleosides & 2-Amino-L-dA

147

Modified deoxy nucleosides: 5-Aza-dC, 3'-Azido-T, dNeubularine, 3'-O-Levulinyl-dG, 2'-Amino-dC, Iso-dG

148

Modified deoxy nucleosides: 7-Deaza-(dA, dG & dI), 7-Deaza-7-iodo-(dA & dG), 7-Deaza-6-O-methyl-dG

149

Ribo nucleosides & modified ribo nucleosides: 5-Methyl-C, rT, N6-Dimethyl-A, Ara-5-Methyl-C & arabinose-U

1502'-Fluoro-2'-deoxy nucleosides, Thio-ribo (U & G), 6-Chloro-ribo inosine, Modified-purines-ribo nucleosides

151

Halogenated-ribo nucleosides

152

Etheno A & C, N-Alkylated & 5-Propynyl C & U modified-ribo nucleosides

153

2, 2'-Anhydro C & U,

154

L-Ribo nucleosides

155

7-Deaza ribo nucleosides

156

2'-O-Methyl ribo nucleosides & modified 2'-O-Methyl ribo nucleosides

157

2'-O-Methyl-5-propynyl-rC & rU nucleosides, 3'-O-Methyl ribo nucleosides & 3'-O-Methyl-5-Methyl rC

158

2'-O-Allyl-ribo nucleosides, 3'-O-Allyl-ribo nucleosides

159

2'-O-Propargyl-ribo nucleosides, 3'-O-Propargyl-ribo nucleosides

160

5',3'-Tetraisopropyl-disiloxane-ribo nucleosides

161

ix

Nucleosides (Base-N-protected)
Standard & labile deoxy nucleosides

162Standard & labile ribo nucleosides, 5-Methyl rC

163

5',3'-Tetraisopropyl-disiloxane-ribo nucleosides & 2', 3'-Isopropylene ribo nucleosides

164

2',3'-O-Diacetyl-ribo nucleosides

165

N-Alkylated, 3'-(O-Allyl) & 2,2'-Anhydro modified nucleosides

166

5'-O-Levulinyl & 3'-O-Levulinyl-deoxy nucleosides

167

3'-O-Acetyl-deoxy nucleosides

168

DMTr Protected Nucleosides
Deoxy nucleosides with standard & labile protection

169

Ribo nucleosides with standard & labile protection

170

Modified deoxy nucleosides

171-173

Modified deoxy halogenated nucleosides

174

Modified ribo nucleosides

175

2'-O-Methyl-ribo nucleosides & 5-Alkyl-2'-O-methyl-ribo nucleosides

176

2'-O-TBDMS-ribo-nucleosides

177

3'-O-TBDMS-ribo-nucleosides

178

Reagents for Nucleic Acid Chemistry
Activation reagents, ETT, BMT, DCl, di-ipr-1H-tetrazolide, 1H-1,2,4- Triazole, MSNT179

DMTr-Chloride, MMTr-Chloride, TMTr-Chloride

180

Sufurizing reagents-PADS, Beaucage Reagent , DDTT

181

Phosphorylating Reagents

182-183

4- Isopropyl-phenoxy-acetylchloride & Bis-silylating reagent (TIPS chloride)

183

Purines, Pyrimidines & Sugars

184

Fluorescein and Biotin NHS esters
Fluoresceins: 5 & 6-FAM-Dipivalate NHS Esters, 5 & 6-FAM NHS Esters

185

Biotins: Biotin-Amido-hexanoic-acid NHS ester, Biotin-N-hydroxysuccinimide ester & Biotin-X-Y-SSE

186

Monophosphates2’-O-Methyl-ribo-monophosphates, b-L-ribo-monophosphates

187

Modified monophosphates : 3'-Amino-rG, Etheno-rC, Iso-rG, 3'-Methyl-rG, rT

188

Deoxy-N-Alkylated A & C, Etheno-dC, 7-Deaza-dA

189

Diphosphates
2'-O-Methyl-ribo-3’,5’-diphosphates, Ribo-U-5'-diphosphate

190

Triphosphates
2'-O-Methyl-ribo-5’-triphosphates, Iso-rG-triphosphate

191

Etheno-dA & dC, 7-Deaza-dA & dG, Iso-dG triphosphates

192

Ara-5’-triphosphates & Ara-(2'-O-methyl)-triphosphates

193

7-Deaza-7-propargylamine-A & G-triphosphate, 2',3'-Dideoxy-G, 5-Propargylamine-2',3'-dideoxy-C & U triphosphate

194

Appendix & Index
Common Abbreviations

195-196

Index-1: Common name index

197-230

Index-2: IUPAC name index

231-260xOrderingTools for Information
Molecular Biology Research
Quality:

ChemGenes Corporation products are manufactured under carefully controlled conditions and whenever applicable are constantly analyzed by Ultra Violet (UV) Spectroscopy. Thin Layer Chromatography,
Electrophoresis, High Performance Liquid Chromatography (HPLC), Enzymatic, and Sequential Analysis. A
product analysis report is enclosed with each shipment of our products.

Terms and Conditions of Sale:

ChemGenes Corporation products are sold for laboratory and manufacturing use only. Our products are notfor use in humans for drugs or clinical diagnostics. Our products in many cases require special storage andhandling, and should be handled only by trained personnel who are aware of the potential hazards andutilize appropriate safeguard. Liability for any loss or damage which may arise from the sale, storage, use,and handling of these products is solely the responsibility of the purchaser. Purchaser is also solely responsible for compliance with any restrictions on exporting any of ChemGenes products. ChemGenes does notassume an responsibility for patent infringement which may occur with the use of these products.
Should any of our products fail to meet the specifications for such product, ChemGenes Corporation will,in its discretion, either replace the products free of charge or refund the purchase price. The foregoing is
the sole remedy, at law or in equity, on account of any failure of the products to meet the specifications.
EXCEPT AS EXPRESSLY SET FORTH ABOVE, CHEMGENES CORPORATION DISCLAIMS ALL OTHER WARRANTIES,EXPRESS OR IMPLIED, WITH RESPECT TO THE PRODUCTS, INCLUDING,WITHOUT LIMITATION, ALL WARRANTIESOF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. CHEMGENES DOES NOT WARRANT THAT THE
PRODUCTS ARE ERROR-FREE OR WILL ACCOMPLISH ANY RESULT.
In no event shall ChemGenes be liable for any lost profits, loss of goodwill, or any incidental, special orconsequential damages, even if it has been advised of the possibility of such damages.
NOTWITHSTANDING ANYTHING TO THE CONTRARY HEREIN, IN NO EVENT SHALL CHEMGENES LIABILITY (WHETHER BYREASON OF BREACH OF WARRANT, BREACH OF CONTRACT, INJURY OR OTHERWISE) EXCEED THE TOTAL PURCHASE
PRICE PAID BY PURCHASER TO CHEMGENES WITH RESPECT TO THE PRODUCTS THAT GIVE RISE TO SUCH LIABILITY.
Any damage, due to thawing or breakage in transit, must be reported in less than five days. Any quality
related problems, which do not conform to the technical data sheet, must be reported in less than thirty
days. No return authorization or credit will be allowed after thirty days. All products returned need proper
authorization from ChemGenes.
The information supplied in this catalog is correct to the best of our knowledge. ChemGenes shall not beliable for any errors of clerical nature in prices or statements contained on our website, in our catalog, product literature, labels, and product data sheet. All errors are subject to correction.
Errors:ChemGenes Corporation shall not be liable for any errors of clerical nature in prices or statements containedin our catalog, product literature, labels, and product data sheet. All errors are subject to correction.

xi

OUR COMMITMENT TO YOU:
THE MOST COMPETITIVE PRICES& HIGHEST QUALITY
Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Please include the following information with each order:• Our catalog number.
• Product name.
• Quantity.
• Your purchase order number.
• Shipping and billing address.

Quotations for quantities in excess of those listed in our catalog will be supplied upon request.

Delivery:

Orders for the products listed in our catalog will be filled promptly from our stock. When complete shipments
cannot be made, partial shipments will be made at our discretion or if agreed upon with the customer.
All international orders must be 100% pre-paid (including shipping and handling charges) prior to shipment.
Payment terms for U.S. customers are determined in ChemGenes discretion. Purchaser is solely responsible
for any sales taxes, VAT, duties, and other similar charges in connection with the purchase of the products.
All products are shipped freight paid with ChemGenes reserving the right to choose the best possible shipping method.
Shipping dates provided by ChemGenes are given on the basis of the best available information on hand.
However, ChemGenes shall not be liable for any loss, damage or expense (consequential or otherwise)
incurred by the purchaser if ChemGenes fails to meet specified delivery dates.

Title of Products & Shipment:

The title of goods and products sold hereunder shall pass to the purchaser upon delivery of products to thecarrier. All shipments are F.O.B. ChemGenes Warehouse.
The rights and obligations of the parties hereunder shall be governed by and construed in accordance withthe laws of the Commonwealth of Massachusetts, without reference to its choice of law provisions. By placing an order with ChemGenes, the purchaser expressly agrees that these Terms and Conditions shall govern
any purchase or sale of ChemGenes products and supersedes any inconsistent provisions contained in any
purchase order, invoice or any other document or agreement from purchaser. The purchaser irrevocably
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action arising out of or related to this Agreement, and waives any right to a trial by jury. Any action arisingunder this Agreement must be brought within one (1) year from the date the cause of action arose.

xii

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Email: info@chemgenes.com

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis

Quality Control Criteria for UltraPure DNA Phosphoramidites
31

P NMR

HPLC

• Single or double peak
• Detection limit: 0.5%

151.299
149.299• Single or double peak
• Detection Limit: 0.08%
85000
80000
75000
70000
65000
60000
55000
50000
45000
40000
35000
30000
25000
20000
15000
10000
5000
0
-5000

76.02
23.98

230

220

210

200

190

180

170

160

150

140

130

120

110

100 90f1 (ppm)

80

70

60

50

40

30

20

10

0

-10

-20

31

P NMR of 5’-O-DMTr -2’-O-TBDMS Guanosine ((N-iBu) 3’-CEP

HPLC Graph of 5’-O-DMTr -2’-O-TBDMS Adenosin (N-Bz) 3’-CEP

UV Characterization• Used to characterize the purine or pyrimidine structure and substituent

UV Spectrum of dC (N-Bz) CEP

Solubility Test

• 200 mg of pure dry product in
1.0 ml of dry acetonitrile(H2O Content < 0.004-0.005 g/ 100 ml)

UV Spectrum of dA (N-Bz) CEP

Coupling Test

• Greater than 99% under set conditions specified in the data sheet supplied with compound.

1

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

As the market for oligonucleotides continues to grow,
ChemGenes remains committed to introducing novel
products, while maintaining its existing product mix.
We also have the capacity to custom synthesize products
on request.

P NMR• Doublet peak or single peak.
• Position of each peak is known for each
phosphoramidite.
• The value between the peaks is calculated
and recorded.

31

UV – The UV test provides 4 values of data:• The ratio between 250/260 nm.
• The ratio between 260/280 nm.
• emax position.
• Extinction Coefficient.

• Robust quality system to ensure full documentationof products for oligonucleotide Therapeutics.

MASS Spectrum• ESI-MS performed on each product.

• Each lot of phosphoramidite must pass establishedtesting criteria before it can be shipped tocustomers.

1

ChemGenes Corporation is dedicated to producing
LC/MShigh quality products for DNA/RNA synthesis to our customers • LC-MS performed on each product.
through:

TLC• Single or double spot (depends on the phosphoramidite)with no other visible impurity on spotting,
0.2 mg/spot.
Moisture Content: <0.1% (<1000 PPM)
Optical Rotation (for L-Amidites): Angle of Rotationismeasured.

Antisense• Amidites completely dissolve in Acetonitrile to
make a 0.1M Solution (water <0.004-0.005
gm/100 mL). Leaves no visible particulate matter.
Coupling Efficiency• The coupling efficiency of ChemGenes phosphoramidite
products are functionally tested to98% or better.

Email: info@chemgenes.com

Chromophores &Ligands2

www.chemgenes.com

RNA Purification• Excellence in Manufacturing• Long Term Relationships• Providing Value• Satisfaction• On-Time Delivery, and• Continually Improving the effectiveness of ourQuality Management System.
Required QC Tests for Most Phosphoramidites
Solubility test

Modified RNA

ChemGenes Quality Policy Statement

H NMR• Proton NMR analysis is performed for each product.
GC-MS and Head Space Analysis for solvent low
volatile substancesStandard RNA• ChemGenes takes pride in a long history ofcustomer satisfaction in supplying the highest purity
phosphoramidites & supports for oligonucleotide
synthesis.

DNA Purification

Our quality is guaranteed! We want to assure you thatevery product is of the highest purity and conforms to
the certificate of analysis that accompanies it whenshipped.

HPLC• Greater than 98% purity by HPLC.

Modified DNA

ChemGenes has been in business for over 33 years and for over 10 years are establishedin a state of the art facility just outside of Boston, Massachusetts, USA. ChemGenes has
full scale modernized facilities to manufacture in bulk while maintaining its high quality.
We have added many new products to our original line to facilitate and stay current inresearch & development in the area of biotechnology.

Ancillary Reagents

Quality Control Criteria for UltraPure DNA Phosphoramidites

Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis
Amidites for Natural DNA Synthesis with Standard Base Protection
B
RO
O
O
P
N

OCE

R

B

Protection

Catalog#

CAS No:

DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
MMTr
MMTr
MMTr
MMTr

A
C
G
T
C
C
A
G
C
T

N-Bz
N-Bz
N-iBu
N/A
N-iBu
N-Ac
N-Bz
N-iBu
N-Bz
N/A

ANP-5551
ANP-5552
ANP-5553
ANP-5554
ANP-5559
ANP-5560
ANP-5556
ANP-5557
ANP-5558
ANP-5561

98796-53-3
102212-98-6
93183-15-4
98796-51-1
110522-84-4
154110-40-4

Catalog #Product Name

250mg

500mg

1g

2g

5g

10g

30g

ANP-5551

2’-Deoxy-adenosine (N-Bz)3’-CEP, M.W. 857.92
2’-Deoxy-cytidine (N-Bz)
3’-CEP, M.W. 833.89
2’-Deoxy-guanosine (N-iBu)
3’-CEP, M.W. 839.90
Thymidine-3’-CEP, M.W. 744.81$10.00$18.00$32.00$58.00$130.00$216.00$580.00$10.00$18.00$32.00$58.00$130.00$216.00$580.00$10.00$18.00$32.00$58.00$130.00$216.00$580.00$10.00$18.00$32.00$58.00$130.00$216.00$580.00$15.00$27.00$51.00$86.00$210.00$400.00$950.00$10.00$18.00$32.00$58.00$130.00$216.00$580.00$15.00$27.00$51.00$86.00$210.00$400.00$950.00$15.00$27.00$51.00$86.00$210.00$400.00$950.00$15.00$27.00$51.00$86.00$210.00$400.00$950.00$15.00$27.00$51.00$86.00$210.00$400.00$950.00

ANP-5552
ANP-5553
ANP-5554
ANP-5559
ANP-5560
ANP-5556
ANP-5557
ANP-5558
ANP-5561

2’-Deoxy-cytidine (N-iBu)3’-CEP, M.W. 799.89
2’-Deoxy-cytidine (N-Ac)3’-CEP, M.W. 771.84
MMTr-2’-deoxy-adenosine (N-Bz)3’-CEP, M.W. 827.91
MMTr-2’-deoxy-guanosine (N-iBu)3’-CEP, M.W. 809.89
MMTr-2’-deoxy-cytidine (N-Bz)3’-CEP, M.W. 803.88
MMTr-Thymidine3’-CEP, M.W. 714.79

Mixed Phosphoramidites (Equimolar)(ANP-5551, ANP-5552 or 5559 or 5560, ANP-5553 and ANP-5554)

Catalog #Quantity

PricesANP-1070

250mg
500mg
1g
2g

$30.00$55.00$100.00$180.00

Typical Deprotection Conditions• 45 minutes at R.T. for cleavage of oligo from support with concentrated ammonium hydroxide.
• Cleavage of base protection can be accomplished by either:using concentrated ammonium hydroxide at 37°C for 16-24 hours, orusing concentrated ammonium hydroxide at 55°C for 6-8 hours.
(time ranges are dependant on the oligo chain length)

for faster deprotection conditions
please see pages 5 & 7

Advantages and application of 5’ -MMTr in Purine Bases for Oligo Synthesis
Due to the use of 5-ethylthiotetrazole (in most DNA/RNA Synthesis Protocols), which is more acidic in nature compared to 1-H-Tetrazole, the DMTr groupfrom purine bases is removed to a certain extent in the coupling step during oligo synthesis, thereby causing undesired M+1 oligo growth.
Since purine bases, A & G, cleave at the 5’-DMTr at a much higher rate than 5’-MMTr, the 5’-MMTr protected nucleoside phosphoramidites is preferred; thus offering a minimal level of M+1 impurities.

3

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

DMTrOOOO

B

Protection

Catalog #

A
C
G
T
C
C
G

N-Bz
N-Bz
N-iBu
N/A
N-iBu
N-Ac
N-DMF

N-5101
N-5102N-5103N-5104
N-5112
N-5212
N-9898

Bulk CPG

Pore Size

2’-Deoxyadenosine(N-Bz)-3’-lcaa-CPG
2’-Deoxycytidine(N-Bz)-3’-lcaa-CPG

Thymidine-3’-lcaa-CPG

2’-Deoxycytidine(N-Ac)-3’-lcaa-CPG
2’-Deoxyguanosine(N-DMF)-3’-lcaa-CPG

pack of 10 cols.

100

1

5

40

0.2

1.0

10

15

40

0.2

1.0

mg

g

g

nmole

µmole

µmole

µmole

µmole

nmole

µmole

µmole

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$14

$81

$280

$26

$33

$40

$91

$126

$54

$62

$78

Modified RNA

2’-Deoxycytidine(N-iBu)-3’-lcaa-CPG

eachStandard RNA

2’-Deoxyguanosine(N-iBu)-3’-lcaa-CPG

RNA Purification

500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å

pack of 4 cols.

DNA Purification

N-5101-05
N-5101-10
N-5101-20
N-5102-05
N-5102-10
N-5102-20
N-5103-05
N-5103-10
N-5103-20
N-5104-05
N-5104-10
N-5104-20
N-5112-05
N-5112-10
N-5112-20
N-5212-05
N-5212-10
N-5212-20
N-9898-05
N-9898-10
N-9898-20

Product Name

Modified DNA

lcaa-CPGOCatalog #Ancillary Reagents

Solid Supports for Natural DNA Synthesis with Standard
Base Protection

B

Antisense

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

Email: info@chemgenes.com

Chromophores &Ligands

4

www.chemgenes.com

Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis
Amidites for Natural DNA Synthesis with Labile (Mild) Base Protection
B
RO
O
O
P
N

Catalog #ANP-6661
ANP-6565
ANP-6662
ANP-5668
ANP-5554
ANP-6769
ANP-6767
ANP-5568
ANP-5569
ANP-5518
ANP-5116
ANP-5117
ANP-5118

OCE

R

B

DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
MMTr
MMTr

A
A
C
G
T
G
A
G
A
G
A
G

MMTr

G

Product name2’-Deoxyadenosine (N-PAC)3’-CEP, M.W. 887.96
2’-Deoxyadenosine (N-DMA)3’-CEP, M.W. 822.93
2’-Deoxycytidine (N-PAC)3’-CEP, M.W. 863.93
2’-Deoxyguanosine (N-tBPAC)3’-CEP, M.W. 960.06
Thymidine3’-CEP, M.W. 744.81
2’-Deoxyguanosine (N-DMF)3’-CEP, M.W. 824.90
2’-Deoxyadenosine (N-diBz)3’-CEP, M.W. 962.04
2’-Deoxyguanosine (N-iPr-PAC)3’-CEP, M.W. 946.04
2’-Deoxyadenosine (N-tBPAC)3’-CEP, M.W. 944.06
2’-Deoxyguanosine(N-Phenyl Ac)-3’-CEP, M.W. 887.38
MMTr-2’-deoxyadenosine (N-PAC)3’-CEP, M.W. 857.93
MMTr-2’-deoxyguanosine (N-tBPAC)3’-CEP, M.W. 930.04
MMTr-2’-deoxyguanosine (N-PAC)3’-CEP, M.W. 873.93

Protection

Catalog#

CAS No:

N-PAC
N-DMA
N-PAC
N-tBPAC
N/A
N-DMF
N,N-di-Bz
N-iPrPAC
N-tBPACN-Phenyl AC
N-PAC
N-tBPACANP-6661
ANP-6565
ANP-6662
ANP-5668
ANP-5554
ANP-6769
ANP-6767
ANP-5568
ANP-5569
ANP-5518
ANP-5116
ANP-5117110543-74-3

N-PAC

ANP-5118

149989-60-6
98796-51-1
330628-04-1
150065-82-0
149989-58-2

250mg

500mg

1g

2g

5g

10g

$14.00$25.00$45.00$80.00$180.00$320.00$14.00$25.00$45.00$80.00$180.00$320.00$14.00$25.00$45.00$80.00$180.00$320.00$14.00$25.00$45.00$80.00$180.00$320.00$10.00$18.00$32.00$58.00$130.00$216.00$14.00$25.00$45.00$80.00$180.00$320.00$25.00$45.00$81.00$160.00$340.00$590.00$20.00$36.00$65.00$115.00$263.00$473.00$20.00$36.00$65.00$115.00$263.00$473.00$20.00$36.00$65.00$115.00$263.00$473.00$20.00$36.00$65.00$117.00$263.00$473.00$20.00$36.00$65.00$117.00$263.00$473.00$20.00$36.00$65.00$115.00$263.00$473.00

Typical Deprotection Conditions• 45 minutes at R.T. for cleavage of oligo from support with concentrated ammonium hydroxide.
For faster deprotection conditions• Cleavage of base protection can be accomplished by either:please see page 7
using concentrated ammonium hydroxide at 37°C for 6-8 hours, orusing concentrated ammonium hydroxide at 55°C for 2-4 hours.
(time ranges are dependant on the oligo chain length)
For Ammonia Free Oligo Deprotection Solution (Catalog # RN-1435, page #59) that can be used with the products on this pages 5 and 6.
The capping reagent phenoxy acetic anhydride is available for capping during oligonucleotide synthesis, please see pages 19-25.
For a description of the advantages of using 5’-MMTr nucleoside phosphoramidities, please see page # 3.

5Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis

DMTrO
O
O
lcaa-CPG
O

B

Protection

Catalog #

A
C
G
T
G

N-PAC
N-PAC
N-PAC
N/A
N-iPrPAC

N-P5101
N-P5102
N-P5103
N-5104N-P5106

Bulk CPG

Pore Size

2’-Deoxyadenosine(N-PAC)-3’-lcaa CPG
2’-Deoxycytidine(N-PAC)-3’-lcaa CPG
2’-Deoxyguanosine(N-PAC)-3’-lcaa CPG

2’-Deoxyguanosine(N-iPrPAC)3’-lcaa CPG

pack of 10 cols.

100

1

5

40

0.2

1.0

10

15

40

0.2

1.0

mg

g

g

nmole

µmole

µmole

µmole

µmole

nmole

µmole

µmole

$14 $115

$540

$25

$30

$45

$140

$210

$50

$62

$94

$14 $115

$540

$25

$30

$45

$140

$210

$50

$62

$94

$14 $115

$540

$25

$30

$45

$140

$210

$50

$62

$94

$7

$60

$260

$24

$30

$38

$80

$110

$50

$62

$75

$14 $115

$540

$25

$30

$45

$140

$210

$50

$62

$94

Standard RNA

Thymidine-3’-lcaa CPG

500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å

each

DNA Purification

N-P5101-05
N-P5101-10
N-P5101-20
N-P5102-05
N-P5102-10
N-P5102-20
N-P5103-05
N-P5103-10
N-P5103-20
N-5104-05
N-5104-10
N-5104-20
N-P5106-05
N-P5106-10
N-P5106-20

Product Namepack of 4 cols.

Modified DNA

OCatalog #Ancillary Reagents

Solid Supports for Natural DNA Synthesis with Labile (mild)
Base Protection

B

Modified RNA

For deprotection conditions please refer to page # 5.

RNA Purification
Antisense

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

6

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis
Fast Deprotection Phosphoramidites using AMA Reagents

B
DMTrO
O
O
P
N

Catalog #ANP-6661
ANP-5560
ANP-5668
ANP-5554

OCE

B

Protection

Catalog#

CAS No:

A
C
G

N-PAC
N-Ac
N-tBPACANP-6661
ANP-5560
ANP-5668

110543-74-3
154110-40-4
149989-60-6

T

N/A

ANP-5554

98796-51-1

Product name2’-Deoxyadenosine (N-PAC)3’-CEP, M.W. 887.96
2’-Deoxycytidine (N-Ac)3’-CEP, M.W. 771.84
2’-Deoxyguanosine (N-tBPAC)3’-CEP, M.W. 960.06
Thymidine3’-CEP, M.W. 744.81

250mg

500mg

1g

2g

5g

10g

$14.00$25.00$45.00$80.00$180.00$320.00$10.00$18.00$32.00$58.00$130.00$216.00$14.00$25.00$45.00$80.00$180.00$320.00$10.00$18.00$32.00$58.00$130.00$216.00

Deprotection Conditions• 5 minutes at room temperature (for cleavage of oligo) using AMA Reagent. AMA (Catalog # RN-1450 listed on page #21) is a 50:50 (v/v) ratio of
ammonium hydroxide and methyl amine.
• Cleavage of base protecting groups can be accomplished by either: using AMA at 37 °C for 30 minutes, or using AMA at 55°C for 10 minutes.
For shorter sequences, standard base protected dA (N-Bz) amidite ANP-5551, dG (N-iBu) amidite ANP-5553, along with dC (N-Ac) amidite ANP-5560
are all recommended; however, for longer sequences it is recommended to use the above Fast Deprotecting Phosphoramidites, i.e. dA (N-PAC) amidite, dG (N-tBPAC) amidite, with the dC (N-Ac) amidite.
NOTE: Ancillary reagents for DNA synthesis using Fast Deprotecting Phosphoramides are available at ChemGenes and are listed on pages19-25.

B
DMTrO
O
O
P
N

Base Unprotected Amidites
B

Protection

Catalog#

CAS No:

A
C
G

none
none
none

ANP-7771
ANP-7772
ANP-7773

140613-55-4
140613-57-6
140613-56-5

OCE

Catalog #Product name

250mg

500mg

1g

2g

ANP-7771

2’-Deoxyadenosine3’-CEP, M.W. 753.83
2’-Deoxycytidine3’-CEP, M.W. 729.80
2’-Deoxyguanosine3’-CEP, M.W. 769.83$60.00$110.00$200.00$380.00$60.00$110.00$200.00$380.00$60.00$110.00$200.00$380.00

ANP-7772
ANP-7773

ChemGenes now offers deoxy nucleoside phosphoramidites of dA,dC & dG which do not have base protecting groups. The oligonucleotide coupling
per step goes essentially quantitative. The synthesis using these phosphoramidites allows oligonucleotide synthesis which does not require ammonia
normally used for base deprotection.

7

Toll Free: (800) 762-9323
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Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis

Ancillary ReagentsB

Natural DNA P-methoxy Amidites

RO
O
O
P
N

ANP-3761
ANP-3762
ANP-3769
ANP-3763

ANP-3764
ANP-3766

CAS No:ANP-3761
ANP-3762
ANP-3769
ANP-3763
ANP-3768
ANP-3764
ANP-3766
ANP-3767

84416-82-0
84416-83-1
833480-37-8
84416-84-2

Product Name
2’-Deoxyadenosine (N-Bz)-5’DMTr
3’-methyl phosphoramidite, M.W. 818.90
2’-Deoxycytidine (N-Bz)-5’DMTr
3’-methyl phosphoramidite, M.W. 794.87
2’-deoxycytidine (N-Ac)- 5’DMTr
3’-methyl phosphoramidite, M.W. 732.80
2’-Deoxyguanosine (N-iBu)- 5’DMTr
3’-methyl phosphoramidite, M.W. 800.88
2’-deoxyguanosine (N-DMA)-5’DMTr
3’-methyl phosphoramidite, M.W. 783.90
Thymidine-5’DMTr
3’-methyl phosphoramidite, M.W. 705.78
5’-MMTr-2’-deoxyadenosine (N-Bz)3’-methyl phosphoramidite, M.W. 788.87
5’-MMTr-2’-deoxyguanosine (N-iBu)3’-methyl phosphoramidite, M.W. 770.85

107573-07-9

250mg

500mg

1g

2g

5g

$20.00$36.00$65.00$115.00$263.00$20.00$36.00$65.00$115.00$263.00$25.00$45.00$80.00$146.00$328.00$20.00$36.00$65.00$115.00$263.00$30.00$54.00$85.00$155.00$360.00$20.00$36.00$75.00$145.00$263.00$25.00$45.00$80.00$146.00$328.00$25.00$45.00$80.00$146.00$328.00

Natural DNA methyl phosphoramidites
Methyl phosphate can be also used for aminoalkyl-phosphoramidate oligonucleotide modification that can be introduced postsynthetically. Similar pathway for postsynthetic labeling was applied using H-phosphonates strategy.

•

For natural phospodiester: use thiophenol solution (Catalog # RN-1465 on page # 19-25) to thoroughly remove the P-Methoxy groups prior to ammonia basedeprotection.
•
In the anti-sense study, the neutral phosphate triester backbone displayed high nuclease resistance and improved cellular uptake. For P-Methoxy phospodiester
oligonucleotides: use PAC protected methylphosphoramidites listed on page # 104 in combination with our ammonia free deprotection solution listed on page #59.
Please see page #104 for DNA methyl phosphoramidites with labile base deprotection (PAC).
Please see page #102 for DNA methyl phosphonamidites.
Please see page #100 for DNA ethyl phosphoramidites.

RNA Purification

Important : Deprotection Conditions

Modified RNA

ANP-3767

Catalog#

N-Bz
N-Bz
N-Ac
N-iBu
N-DMA
N/A
N-Bz
N-iBu

Standard RNA

ANP-3768

Protection

A
C
C
G
G
T
A
G

DNA Purification

Catalog #

B

DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
MMTr
MMTr

Modified DNA

OCH3

R

Antisense

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

8

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis
P-O-benzyl Phosphoramidites

B
DMTrO
O

B

Protection

Catalog#

O

A
C
G
T

N-Bz
N-Bz
N-iBu
N/A

ANP-6731
ANP-6732
ANP-6733
ANP-6734

OP
N

Catalog #ANP-6731
ANP-6732
ANP-6733
ANP-6734

Product name2’-Deoxyadenosine (N-Bz)
3’-O-benzyl phosphoramidite, M.W. 894.99
2’-deoxycytidine (N-Bz)
3’-O-benzyl phosphoramidite, M.W. 870.97
2’-deoxyguanosine (N-iBu)
3’-O-benzyl phosphoramidite, M.W. 876.98
Thymidine
3’-O-benzyl phosphoramidite, M.W. 781.87

100mg

250mg

500mg

1g

2g

$24.00$54.00$90.00$160.00$290.00$24.00$54.00$90.00$160.00$290.00$24.00$54.00$90.00$160.00$290.00$24.00$54.00$90.00$160.00$290.00

Applications of benzyl phosphoramidites:• Synthesis of Natural DNA fragents.
• Cleavage of P-O-benzyl phosphate occurs smoothly with aqueous ammonia.
• The synthesis of sequence specific phosphoramidites.
Nielson, J.; Caruthers, M. H. Jour. Am. Chem Soc. 1988, 110, 6275-6276.

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

9Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis

Ancillary Reagents

Reverse DNA Synthesis
N
P
CEO

B
O
O

Protection

Catalog#

CAS No:

A
C
G
T
C
G
A

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N-DMF
N-PAC

ANP-4671
ANP-4672
ANP-4673
ANP-4674
ANP-4675
ANP-4678
ANP-4681

140712-82-9
140712-83-0
140839-24-3
134031-86-0

250mg

500mg

1g

2g

5g

3’-O-DMTr-2’-deoxyadenosine (N-Bz)
5’-CEP, M.W. 857.92
3’-O-DMTr-2’-deoxycytidine (N-Bz)
5’-CEP, M.W. 833.89$70.00$130.00$230.00$410.00$925.00$70.00$130.00$230.00$410.00$925.00

3’-O-DMTr-2’-deoxyguanosine (N-iBu)
5’-CEP, M.W. 839.90
3’-O-DMTr-Thymidine
5’-CEP, M.W. 744.80
3’-O-DMTr-2’-deoxycytidine (N-Ac)
5’-CEP, M.W. 771.84
3’-O-DMTr-2’-deoxyguanosine (N-DMF)
5’-CEP, M.W. 824.90
3’-O-DMTr-2’-deoxyadenosine (N-PAC)
5’-CEP, M.W. 887.96$70.00$130.00$230.00$410.00$925.00$70.00$130.00$230.00$410.00$925.00$70.00$130.00$230.00$410.00$925.00$70.00$130.00$230.00$410.00$925.00$70.00$130.00$230.00$410.00$925.00

ANP-4672
ANP-4673
ANP-4674
ANP-4675
ANP-4678
ANP-4681

Standard RNA

Product Name

ANP-4671

DNA Purification

Catalog #Modified DNA

ODMTr

B

Reverse 7-Deaza-dG-phosphoramidite (ANP-4679) DNA monomer is listed on page # 34.
Reverse 2’-Fluoro DNA amidites are listed on page # 76.

Standard CPG for Reverse DNA Synthesis
O
O
O

O

ODMTr

B

Protection

Catalog #

A
C
G
T

N-Bz
N-Bz
N-iBu
N/A

N-3351
N-3352
N-3353
N-3354

Bulk CPG

Catalog #2’-Deoxyadenosine(N-Bz)-5’-lcaa CPG
2’-Deoxycytidine(N-Bz)-5’-lcaa CPG

Thymidine5’-lcaa CPG

pack of 10 cols.

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$45

$350

$100

$150

$200

$300

$45

$350

$100

$150

$200

$300

$45

$350

$100

$150

$200

$300

$45

$350

$100

$150

$200

$300

Applications of Reverse Phosphoramidites:• Synthesis of 3’-3’-linked DNA. • Synthesis of special oligonucloetides required to be coupled at the 5’-end selectively.
• Synthesis of oligonucloetide from left to right (5’->3’ direction). • Synthesis of oligonucloetide with specific 3’-conjugation.

www.chemgenes.com
Email: info@chemgenes.com

10

Chromophores & Ligands

500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å

pack of 4 cols.

100

Antisense

2’-Deoxyguanosine(N-iBu)-5’-lcaa CPG

Pore Size

RNA Purification

N-3351-05
N-3351-10
N-3351-20
N-3352-05
N-3352-10
N-3352-20
N-3353-05
N-3353-10
N-3353-20
N-3354-05
N-3354-10
N-3354-20

Product Name

Modified RNA

B

CPG-lcaa

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis
O
B

OPolystyrene Spacer

O
O
ODMTr

Catalog #PS-7511-03
PS-7515-03
PS-7513-03
PS-7514-03

Product Name
2'-Deoxy-Adenosine (N-Bz)5’-succinyl Polystyrene Support
2'-Deoxy-Cytidine (N-Ac)5’-succinyl Polystyrene Support
2’-Deoxy-Guanosine (N-iBu)5’-succinyl Polystyrene Support
Thymidine5’-succinyl Polystyrene Support

Succinyl Polystyrene Supports for Reverse DNA
Synthesis
B

Protection

Catalog #

A
C
G
T

N-Bz
N-Bz
N-iBu
N/A

PS-7511
PS-7515
PS-7513
PS-7514

Bulk Polystyrene
Loading 30-40 μm/g

Pore
Size

Particle
Size

100

1

5

40

mg

g

g

300Å

15-20 µm

$35

$245

$35

pack of 4 cols.

pack of 10 cols.

0.2

1.0

40

0.2

1.0

nmole

µmole

µmole

nmole

µmole

µmole

$753

$50

$65

$80

$100

$130

$160

$245

$753

$50

$65

$80

$100

$130

$160

$35

$245

$753

$50

$65

$80

$100

$130

$160

$35

$245

$753

$50

$65

$80

$100

$130

$160

60-70 µm300Å15-20 µm60-70 µm300Å15-20 µm60-70 µm300Å15-20 µm60-70 µm

High Loading Succinyl Polymeric Supports for
Reverse DNA Synthesis (loading greater than 150 μmol/g)

Catalog #PMS-7311-03
PMS-7315-03
PMS-7313-03
PMS-7314-03

Product Name
2'-Deoxy-Adenosine (N-Bz)5’-succinyl Polymeric support
2'-Deoxy-Cytidine (N-Ac)5’-succinyl Polymeric support
2’-Deoxy-Guanosine (N-iBu)5’-succinyl Polymeric support
Thymidine5’-succinyl Polymeric support

B

Protection

Catalog #

A
C
G
T

N-Bz
N-Bz
N-iBu
N/A

PMS-7311
PMS-7315
PMS-7313
PMS-7314

Pore
Size

Particle
Size

1

2

5

g

g

g

10
g

700-800Å

37-74 μm

$240

$384

$768

$1,230700-800Å

37-74 μm

$240

$384

$768

$1,230		

700-800Å

37-74 μm

$240

$384

$768

$1,230700-800Å

37-74 μm

$240

$384

$768

$1,230ChemGenes has developed unique Polystyrene Support sand columns that have special appeal due to rigidity, non-swelling, and inertness
towards moisture and water.
Our Polymeric Support has a special linker and different pore size . This unique cross-linking nature matches very closely with the commonlyused CPG (500 Å).
Our supports have consistently displayed outstanding performance for the synthesis of medium length oligos of varying sizes.

11

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis
B
O

Levulinyl DNA Phosphoramidites with Standard Base
Protection

O
O
O
P
N

Ancillary ReagentsO

OCE

Protection

Catalog#

CAS No:

N-Bz
N-Bz
N-iBu
N/A

ANP-5001
ANP-5002
ANP-5003
ANP-5004

581076-14-4

Product Name

250mg

500mg

1g

2g

ANP-5001

5’-O-Levulinyl-2’-deoxyadenosine (N-Bz)3’-CEP, M.W. 653.67
5’-O-Levulinyl-2’-deoxycytidine (N-Bz)3’-CEP, M.W. 629.64$50.00$80.00$140.00$250.00$50.00$80.00$140.00$250.00

5’-O-Levulinyl-2’-deoxyguanosine (N-iBu)3’-CEP, M.W. 635.65
5’-O-Levulinyl-Thymidine3’-CEP, M.W. 540.55$50.00$80.00$140.00$250.00$50.00$80.00$140.00$250.00

ANP-5002
ANP-5003
ANP-5004

DNA Purification

Catalog#

Modified DNA

B
A
C
G
T

Standard RNA

Levulinyl Deprotection Solution
Pricing

CLP-7171$44.00 / 5 ml
$72.00 / 10 ml

Modified RNA

Catalog#

5’-O-Levulinyl DNA phosphoramidites can be used when oligonucleotide has acid labile modifications and TCA or DCA formulations cannot be used.
ChemGenes offers levulinyl deprotection solution (Catalog # CLP7171)

RNA Purification

5’-O-Levulinyl DNA Phosphoramidites with Standard Base Protection

Antisense

Please Indicate Synthesizer when Ordering
ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta OligopilotAK12

www.chemgenes.com
Email: info@chemgenes.com

Chromophores & Ligands

ABI

Oligo Synthesis Products
Phosphoramidites and Supports for Natural DNA Synthesis
DNA Dimer Phosphoramidites

B1
DMTrO
O
O
O P
OCE

Catalog#

B2
O
O
P
N

B1
A
A
A
A
C
C
C
C
G
G
G
G
T
T
T
T

B1 Protection
N-Bz
N-Bz
N-Bz
N-Bz
N-Bz
N-Bz
N-Bz
N-Bz
N-iBu
N-iBu
N-iBu
N-iBu
N/A
N/A
N/A
N/A

B2
A
C
G
T
A
C
G
T
A
C
G
T
A
C
G
T

Pricing

Pricing applies to all
dimers listed below

O$550.00 / 100mg$1,230.00 / 250 mg$2,200.00 / 500 mg$3,750.00 / 1g

10 gram minimum order, call for pricing.

OCE

B2 Protection
N-Bz
N-Bz
N-iBu
N/A
N-Bz
N-Bz
N-iBu
N/A
N-Bz
N-Bz
N-iBu
N/A
N-Bz
N-Bz
N-iBu
N/A

Catalog #ANP-2501-CE
ANP-2502-CE
ANP-2503-CE
ANP-2504-CE
ANP-2505-CE
ANP-2506-CE
ANP-2507-CE
ANP-2508-CE
ANP-2509-CE
ANP-2510-CE
ANP-2511-CE
ANP-2512-CE
ANP-2513-CE
ANP-2514-CE
ANP-2515-CE
ANP-2516-CE

M.W.
1328.311304.28
1310.291215.191304.28
1280.26
1286.271191.161310.29
1286.271292.271197.171215.19
1191.161197.171102.07

Chemical Formula
C67H77N13O13P2
C66H71N11O14P2
C67H73N13O14P2
C66H68N10O14P2
C66H71N11O14P2
C65H71N9O15P2
C63H73N11O15P2
C59H68N8O15P2
C64H73N13O14P2
C63H73N11O15P2
C61H75N13O15P2
C57H70N10O15P2
C66H68N10O14P2
C59H68N8O15P2
C57H70N10O15P2
C53H65N7O15P2

DNA Dimer Phosphoramidites
Main advantage of using dimer phosphoramidites is the absence of n-1 and n+1 impurities in the crude oligonucleotide mixtures.

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

13

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural DNA Synthesis

Ancillary ReagentsB

DNA H-Phosphonate Monomers

DMTrO
B

Protection

Catalog#

CAS No:

O
O P H
O

A
C
G
T
C

N-Bz
N-Bz
N-iBu
N/A
N-Ac

ANP-3410
ANP-3411
ANP-3412
ANP-3413
ANP-3414

118352-75-3
118352-74-2
118352-76-4
3868-27-7

Modified DNA

O

HN

ANP-3410
ANP-3411

ANP-3413
ANP-3414

250mg

500mg

$35.00$65.00$35.00$65.00$35.00$65.00$35.00$65.00$35.00$65.00Standard RNA

ANP-3412

Product name2’-Deoxyadenosine (N-Bz)3’-H-phosphonate TEA Salt, M.W. 822.87
2’-Deoxycytidine (N-Bz)3’-H-phosphonate TEA Salt, M.W. 798.84
2’-Deoxyguanosine (N-iBu)3’-H-phosphonate TEA Salt, M.W. 804.86
Thymidine3’-H-phosphonate TEA Salt, M.W. 709.76
2’-Deoxycytidine (N-Ac)3’-H-phosphonate TEA Salt, M.W. 736.79

DNA Purification

Catalog#

Modified RNA

Ancillary reagents for H-phosphonate chemsitry are listed in page # 19.

RNA Purification

Please Indicate Synthesizer when Ordering
ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

ABI

Akta Oligopilot
AK

14

Email: info@chemgenes.com

Chromophores &Ligands

www.chemgenes.com

Oligo Synthesis Products
Supports for DNA & RNA Synthesis
Succinyl Polystyrene Supports for DNA Synthesis

Catalog #N-7511-03

Product Name
2’-Deoxy-adenosine (N-Bz)2’-Deoxy-cytidine (N-Bz)2’-Deoxy-guanosine (N-iBu)Thymidine2’-Deoxy-cytidine (N-Ac)-

Bulk Polystyrene
Loading 30-40 μm/g

1

5

40

mg

g

g

300Å

15-20 µm

$35

$245

$35

pack of 4 cols.

pack of 10 cols.

0.2

1.0

40

0.2

1.0

nmole

µmole

µmole

nmole

µmole

µmole

$753

$50

$65

$80

$100

$130

$160

$245

$753

$50

$65

$80

$100

$130

$160

$35

$245

$753

$50

$65

$80

$100

$130

$160

$35

$245

$753

$50

$65

$80

$100

$130

$160

$35

$245

$753

$50

$65

$80

$100

$130

$160

60-70 µm300Å15-20 µm60-70 µm300Å15-20 µm60-70 µm300Å3’-succinyl Polystyrene support
N-7515-03

N-7511
N-7512
N-7513
N-7514N-7515100

3’-succinyl Polystyrene support
N-7514-03

Catalog #

N-Bz
N-Bz
N-iBu
N/A
N-Ac

ParticleSize

3’-succinyl Polystyrene support
N-7513-03

Protection

A
C
G
T
C

Pore
Size

3’-succinyl Polystyrene support
N-7512-03

B

15-20 µm60-70 µm300Å3’-succinyl Polystyrene support

15-20 µm60-70 µm

ChemGenes has developed unique Polystyrene Supportsand columns that have special appeal due to rigidity, non-swelling and inertness towards
moisture and water.

High Loading Succinyl Polymeric Supports for DNA
Synthesis (loading greater than 150 μmol/g)

Catalog #PMS-7511-07

Product Name
2’-Deoxy-adenosine (N-Bz)-

B

Protection

Catalog #

A
C
G
T
C

N-Bz
N-Bz
N-iBu
N/A
N-Ac

PMS-7511
PMS-7512
PMS-7513
PMS-7514
PMS-7515

Pore
Size

Particle
Size

1

2

5

g

g

g

10
g

700-800Å

37-74 μm

$240

$384

$768

$1,230700-800Å

37-74 μm

$240

$384

$768

$1,230		

700-800Å

37-74 μm

$240

$384

$768

$1,230700-800Å

37-74 μm

$240

$384

$768

$1,230700-800Å

37-74 μm

$240

$384

$768

$1,2303’-succinyl Polymeric support
PMS-7512-07

2’-Deoxy-cytidine (N-Bz)3’-succinyl Polymeric support

PMS-7513-07

2’-Deoxy-guanosine (N-iBu)3’-succinyl Polymeric support

PMS-7514-07

Thymidine3’-succinyl Polymeric support

PMS-7515-07

2’-Deoxy-cytidine (N-Ac)3’-succinyl Polymeric support

15

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Ancillary Reagents

Non Cleavable Supports and Columns for
DNA/RNA Synthesis

B
DMTrO
O
O
Non Cleavable Spacer-Inert S

Protection

Catalog #A

N-Bz

N-7521C

N-Bz

N-7522

G

N-iBu

N-7523

T

N/A

N-7524

Modified DNA

BO

Catalog #Product Name

Pore Size

Bulk loading
30-40 μm/g

Particle 100Size
mg

2’-Deoxyadenosine (N-Bz)-

300Å

N-7521-60

3’-non-cleavable long chain spacer

300Å

60-70 µm1000Å60-70 µm
15-20 µm

N-7521-10-60
2’-Deoxycytidine (N-Bz)-

300Å

N-7522-60

3’-non-cleavable long chain spacer

300Å

60-70 µm1000Å60-70 µm
15-20 µm

N-7523-15

2’-Deoxyguanosine (N-iBu)-

300Å

N-7523-60

3’-non-cleavable long chain spacer

300Å

60-70 µm1000Å60-70 µm

N-7523-10-60$55

pack of 10 cols.

0.2

1.0

40

0.2

1.0

nmole

µmole

µmole

nmole

µmole

µmole

$280

$110

$130

$150

$220

$260

$300

$55

$280

$110

$130

$150

$220

$260

$300

$55

$280

$110

$130

$150

$220

$260

$300

2’-Deoxycytidine (N-Bz)-

300Å

15-20 µm

N-7522-60

3’-non-cleavable long chain spacer

300Å

60-70 µm1000Å60-70 µm

$55

$280

$110

$130

$150

$220

$260

$300		OO

Polystyrene

DMTrO

Product Name

Bulk loading
30-40 μm/g

Pore Size

Particle 100
Sizemg

N-4545-03

Non-cleavable spacer300Å

15-20 µm

N-4545-10

polystyrene

1000Å50-70 µm

$55

Modified RNA

N
H
6

Catalog #Standard RNA

N-7522-15
N-7522-10-60gpack of 4 cols.

15-20 µm

N-7522-15
N-7522-10-60

40

DNA Purification

N-7521-15

1Standard DNA

Supports for DNA & RNA Synthesis.
pack of 10 cols.

pack of 4 cols.

1

40

0.2

1.0

40

0.2

1.0

g

nmole

µmole

µmole

nmole

µmole

µmole

$280

$110

$130

$150

$220

$260

$300

RNA Purification

Non Cleavable Solid Supports and Columns(For Affinity Chromatography & One bead one Compound combinatorial libraries)
ChemGenes has developed a non-cleavable support, which is inert in nature and is amenable to oligonucleotide synthesis. Using ourirreversible support leads to oligo synthesis of coupling efficiencies of 98-99% per step for a chain length of 20-40 mers.

Chromophores &Ligands

Our Inert beads are uniform particles. The support bound oligonucleotides, which are irreversibly bound, have extensive applications
in molecular biology. Some of the common applications are as follows:
1. Affinity based chromatography for oligonucleotides, proteins, and other macromolecules.
2. Design and construction of one bead one compound libraries by split sythesis methods.
3. PCR amplification is possible with the support attached to oligonucleotides. See photo to the right for bead based aptamer library
screening, sequencing analysis of PCR products.
4. Molecular Biology R&D experiments on bead bound oligonucleotides have performed beyond expectations.
This method has been used by Gorenstein & Coworkers (Yang, X.; Bassett, S. E.; Li, X.; Luxon, B. A.; Herzog, N. K.; Shope, R. E.; Aronson, J.; Prow, T. W.;
Leary, J. F.; Kirby, R.; Ellington, A. D.; Gorenstein, D. G. Nucle. Acids. Res., 2002, 30, e-132) for the selection of combinatorial oligonucleotides aptamer
and PCR amplification followed by sequencing.

photo taken by permission
from Nucleic Acid Research.

www.chemgenes.com
Email: info@chemgenes.com

Antisense

16

Oligo Synthesis Products
Supports for DNA & RNA Synthesis
Unylinker Universal Supports for Synthesis of Oligonucleotides
O
O

DMTrO
O

O

CPG-lcaa

NOO
Bulk CPG

Catalog #N-4000-05
N-4000-10
N-4000-20
N-4000-03

Product Name

Pore Size
500Å
1000Å
2000Å
300Å

UnyLinker lcaa CPG

UnyLinker Polystyrene

pack of 4 cols.

eachpack of 10 cols.

100

250

1

40

0.2

1.0

10

15

40

0.2

1.0

mg

mg

g

nmole

µmole

µmole

µmole

µmole

nmole

µmole

µmole

$8
$8
$10
$14

$18
$18
$22
$27

$65
$65
$75
$80

$26
$26
$30
$38

$32
$32
$36
$44

$40
$40
$48
$56

$85
$85
$98
$109

$52
$52
$62
$70

$64
$64
$74
$82

$80
$80
$96
$104

$120
$120
$142
$149

High Loading Unylinker Universa Succinyl Polymeric Supports
for RNA Synthesis (Loading 150-200 μmol/g)
Catalog #PMS-4000-07

Product Name
UnyLinker Polymeric support

Pore
Size

Particle
Size

1

2

5

g

g

g

10
g

700-800Å

37-74 μm

$85

$150

$640

$960

Unylinker Microarray Slide (Discontinued )Catalog#

O
O

DMTrO
O

O

N-4501

Solid Support-lcaa

N
O

Pricing$16.00 / 1 unit$12.00 / 50 unitO

UNYLINKERTM Universal Support for synthesis of Oliogodeoxynucleotides(Fully compatible with standard phosphoramidite reagents and synthesis conditions) Average coupling efficiency of >99% per step.
Quantitative cleavage from support with standard ammonia or methylamine deprotection conditions.
No need to synthesize four deoxy nucleosides & avoids need to synthesize difficult to procure 2’ or 3’-modified nucleoside based on support
Improvement in the quality of oligonucleotides synthesized, since the quality of succinates can vary from batch to batch and supploer to suppliers.
Cost reduction due to single support for the Oligo synthesis instead of several supports.
Releases work load of QC and material management and testing of many products verses a single support.
UNYLINKER universal support does not contribute any atom to API and hence need not be classified as a starting material.
Therefore offer major advantage when dealing with QA and FDA.
High purity Phosphorothioate synthesis is performed as usual.
2’-O-Alkyl oligonucleotides are synthesized in high purity.
LNA oligonucleotides are synthesized in high high purity.
Fully compatible with Biotin, Fluorescein and other labeled oligonucleotides.
*UNYLINKERTM is a trademark of Isis Pharmaceuticals, Inc. The above products are covered under Isis patent #7,202,264. and ChemGenes
Corp. holds world wide marketing rights.

17

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Modified DNA

Controlled Pore Glass (CPG) is rigid and non-swelling with deep pores in which oligonucleotide synthesis takes place. CPG’s with500 Å (50 nm) pores are mechanically robust and are routinely used in the synthesis of shorter oligonucleotides. However, synthetic
yields fall dramatically when oligonucleotides more than 40 bases in length are prepared on CPG’s with 500 Å. This is because
growing oligonucleotides blocks the pores and reduces diffusion of the reagents through the matrix. Although large pore CPG’s are
more fragile, 1000 Å CPG’s has proved to satisfactory for the synthesis of oligonucleotides up to 100 bases in length, and 2000 Å
supports can be used for the longer length oligonucleotides. CPG’s have a C-17 spacer (lcaa) between the succinate and Silyl groupon the CPG supports. The long chain spacer arm is ≈ 18 Å long. The longer arm facilitates the synthesis of longer oligomers, where
steric effects and surface repulsions are problems. The drop in coupling yield during the attachment of 1st and 2nd phosphoramidite
is minimal and thus the formation of N-1 chain is negligible.
We are proud that the ChemGenes CPG Supports have out performed equivalent products available on the market. All the functional groups available on the derivatized CPGs have been carefully blocked to minimize possibilities of side reactions. CPGs areavailable in three pore diameters and each have been functionalized in three different loading levels.

Ancillary Reagents

Solid Supports & Columns

Standard DNA

Supports for DNA & RNA Synthesis

Amino CPG Long Chain Alkyl (lcaa) Support

Selection Chart of lcaa CPG Supports for optimum oligo chain length
Synthesis Scales
0.05 μm
0.2 μm
0.2 μm
1.0 μmLoading (μm/g)
5-6
15-16
35
90

Recommended Pore Size2000Å1000Å or 2000Å
500Å and 1000Å
500Å

Oligo Chain Length (mer)150-175
61-10030 and 60< 30

Amino lcaa CPG Supports
Catalog#

Pricing

Catalog#

Pricing

N-5100-05$32.00 / 1 g$55.00 / 5 g$85.00 / 10 g

N-5100-10$32.00 / 1 g$55.00 / 5 g$85.00 / 10 g

Standard RNA

Trityl Value Codes
VL: Very Low
L: Low
M: Medium
H: High

DNA Purification

The particle sizes for CPG’s available at ChemGenes are: 80-200 mesh, 80-120 mesh, and 120-200 mesh. However the mostcommon is 120-200 mesh and is used to derivatize our listed CPG’s. Please enquire about the other two mesh sizes, which areavailable on a custom basis.

O
OCH3

H2N

O

nN

OAc

OCH3
Pore Size: 500Ån = 12-16

Pore Size: 1000Å

ChemGenes Corp. uses and sells native amino lcaa CPG with linker length 12 -16;

Product Name
ABI 392/394 Style Empty Column, Aluminum Caps (2), & Frits (2)ABI 392/394 Style Empty Column, Aluminum Caps (2), & Frits (2)Expedite Style Empty Synthesis Column, Aluminum Caps (2), & Frits (2)Expedite Style Empty Synthesis Column, Aluminum Caps (2), & Frits (2)Expedite Style Empty Synthesis Column, Aluminum Caps (2), & Frits (2)ABI3900 & MerMade Style Empty Column & Frits (upper & lower)

Appropriate Scales		 Pricing
40nmol - 1.0μmol		$5.00 each~ 15 μmol		$50.00 each
40nmol - 0.2μmol		$5.00 each
1.0 μmol		$5.00 each
10 μmol		$40.00 each
40nmol - 1.0μmol		$5.00 each

Replacement Filters
Catalog #EPC-1008

Quantity
100

Prices$50.00* can be used for either ABI 392/394 or Expedite Oligonucleotide Synthesizers

www.chemgenes.com
Email: info@chemgenes.com

Antisense

18

Chromophores &Ligands

Catalog#
E-1007-AB30
E-1007-15-AB30
E-1007-02-EX
E-1007-10-EX
E-1007-100-EX
E-1007-AB39

RNA Purification

Empty Columns for Oligonucleotide Synthesizers

Modified RNA

H

Si CPGOligo Synthesis Products
Ancillary Reagents
Ancillary Reagents for Automated DNA Synthesizers(For H-Phosphonate Chemistry)

Catalog #RN-6464

Qty.

Price

Dipentafluorophenyl Carbonate*

Product Name

2g

$85.00(Highly efficient coupling reagent for H-phosphonate

5g$190.002g$45.00100 ml$28.00100 ml$28.00900 ml$77.0045 ml$37.00chemistry and superior to Adamantane carbonyl chloride)
RN-6664

Activator for monomers and Capping Reagent(Adamantane Carbonyl Chloride)

RN-4523-P

Acetonitrile/Pyridine(50:50), Anhydrous(Diluent for Monomers)

RN-1356-P2

Acetonitrile/Pyridine(95:5), Anhydrous(Diluent for Activator)

RN-7684-AP

Acetonitrile/Pyridine(Wash Solvent)

RN-6645-IP

Capping Reagent for ABI Synthesizers(Isopropyl Phosphite/Acetonitrile/Pyridine)

RN-1210-PHT**Oxidation Solution 1

45 ml$18.00

RN-1220-THT(Iodine in Pyridine/H O/THF)
2**Oxidation Solution 2

45 ml$18.00(THF/H O/TEA)
2* Efimov, V. A.; Kalinkina, A. L.; Chakhmakhcheva, O. G. Nucl. Acids. Res., 1993, 2, 5337-5344.
** Note: Both oxidation solutions 1 & 2 are needed for H-phosphonate oxidation.

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

19

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Ancillary Reagents

Activation Reagent(0.45 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)

Activation Reagent(0.25 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)

Activation Reagent(0.25 M 4,5-Dicyanoimidazole/Acetonitrile)

Activation Reagent (BMT Solution)(0.3M Benzylthio-1H-Tetrazole/Acetonitrile)
CAP A(Acetic Anhydride/Pyridine/THF)

CAP B(10% N-Methylimidazole/THF, v/v)

CAP B
(16% N-Methylimidazole/THF, v/v)

Oxidation Solution(0.1 M Iodine/Pyridine/H2O/THF)*** DDTT Solution[0.10 M] (Sulfurizing Reagent)
Silanized Bottles for Beaucage Reagent

100 ml200 ml450 ml100 ml200 ml450 ml100 ml
250 ml500 ml25 ml$65.00$125.00			
$225.00$88.00			$160.00			$310.00
$8.00
$8.00
$8.00
$25.00Antisense

AMA Reagent$15.00$25.00$54.00$230.00$15.00$25.00$54.00$260.00$15.00$25.00$54.54$260.00$47.00$220.00$27.00$108.00$20.00$40.00$168.00$20.00$40.00$168.00$38.00$76.00

RNA Purification*Thiophenol/Triethylamine/Dioxane**Sulfurizing Reagent (Beaucage Reagent) for
Introduction of Phosphorothioate (S-oligonucleotide)*** DDTT Solution[0.05 M] (Sulfurizing Reagent)

45 ml
200 ml450 ml2L
45 ml
200 ml450 ml2L
45 ml
200 ml450 ml2L
450 ml2L
450 ml2L
200 ml450 ml2L
200 ml450 ml2L
10 ml
2g

Modified RNA

DMTr Removal Reagent(3% DCA (Dichloro acetic acid)/Dichloromethane, v/v)
DMTr Removal Reagent(3% TCA (Trichloro acetic acid)/Dichloromethane, v/v)
Oxidation Solution(0.02 M Iodine/Pyridine/H2O/THF)

Price
$9.00
$14.00$20.00$32.00$90.00$35.00$87.00$140.00$410.00$35.00$87.00$140.00$410.00$35.00$87.00$140.00$410.00$35.00Standard RNA

RN-1688
RN-1688
RN-1688
RN-1689
RN-1689
RN-1689
BL-1536-S-AB30
BL-1536-M-AB30
BL-1536-L-AB30
RN-1450-AB30

Acetonitrile Wash Grade

Qty.
45 ml
100 ml450 ml1L
4L
45 ml
200 ml450 ml2L
45 ml
200 ml450 ml2L
45 ml
200 ml450 ml2L
45 ml

DNA Purification

RN-1458-SS-AB30
RN-1458-S-AB30
RN-1458-M-AB30
RN-1458-L-AB30
RN-1481-SS-AB30
RN-1481-S-AB30
RN-1481-M-AB30
RN-1481-L-AB30
RN-7776-SS-AB30
RN-7776-S-AB30
RN-7776-M-AB30
RN-7776-L-AB30
RN-1468-M-AB30
RN-1468-L-AB30
RN-1462-M-AB30
RN-1462-L-AB30
RN-1455-S-AB30
RN-1455-M-AB30
RN-1455-L-AB30
RN-1456-S-AB30
RN-1456-M-AB30
RN-1456-L-AB30
RN-1465-AB30
RN-1535-L-AB30

Product Name
Acetonitrile Anhydrous(Phosphoramidite Diluent & Washings)

Modified DNA

Catalog #RN-1447-S-AB30
RN-1447-M-AB30
RN-1447-L-AB30
RN-1448-M-AB30
RN-1448-L-AB30
RN-1551-SS-AB30
RN-1551-S-AB30
RN-1551-M-AB30
RN-1551-L-AB30
RN-1466-SS-AB30
RN-1466-S-AB30
RN-1466-M-AB30
RN-1466-L-AB30
RN-1467-SS-AB30
RN-1467-S-AB30
RN-1467-M-AB30
RN-1467-L-AB30
RN-1452

Ancillary Reagents

ABI Oligonucleotide Synthesizers* Used in selective removal of P-methoxy groups in oligos.
** For the separate listing of Beaucage Reagent see page 175*** For Bulk pricing and details of Solid DDTT (Sulfurizing Reagents) see page 175.

20

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands*** DDTT Solution (Sulfurizing Reagents) see page 21,24 & 25.

Oligo Synthesis Products
Ancillary Reagents
ABI 3900 Oligonucleotide Synthesizers
Product Name

Qty.

Price

RN-1447-L-AB39

Catalog #***Acetonitrile Anhydrous

450 ml$20.00

RN-1448-M-AB39

Acetonitrile Wash Grade

1L$32.004L$90.00(Phosphoramidite Diluent & Washings)
RN-1448-L-AB39
RN-1551-M-AB39

Activation Reagent (ETT)450 ml$140.00

RN-1551-L-AB39(0.45 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)

2L$410.00

RN-1466-M-AB39

Activation Reagent

450 ml$140.00

RN-1466-L-AB39(0.25 M 5-Ethylthio Tetrazole/Acetonitrile)

2L$410.00

RN-1467-M-AB39

Activation Reagent (DCI)

450 ml$140.00

RN-1467-L-AB39(0.25 M 4,5-Dicyanoimidazole/Acetonitrile)

2L$410.00

RN-1452

Activation Reagent (BMT)

45 ml$35.00(0.3M 5-Benzylthio-1H-Tetrazole/Acetonitrile)
RN-1458-M-AB39

CAP A

450 ml$54.00

RN-1458-L-AB39(Acetic Anhydride/Pyridine/THF)

2L$230.00

RN-1481-M-AB39

CAP B

450 ml$54.00

RN-1481-L-AB39(10% N-Methylimidazole/THF, v/v)

2L

$260.00

RN-7776-M-AB39

CAP B

450 ml$54.00

RN-7776-L-AB39(16% N-Methylimidazole/THF, v/v)

2L

$260.00

RN-1468-M-AB39

DMTr Removal Reagent

450 ml$47.00

RN-1468-L-AB39(3% DCA (Dichloracetic acid)/Dichloromethane, v/v)

2L

$220.00

RN-1462-M-AB39

DMTr Removal Reagent

450 ml$27.00

RN-1462-L-AB39(3% TCA (Trichloracetic acid)/Dichloromethane, v/v)

2L

$108.00

RN-1455-M-AB39

Oxidation Solution

450 ml$40.00

RN-1455-L-AB39(0.02 M Iodine/Pyridine/H2O/THF)

2L$168.00

RN-1456-M-AB39

Oxidation Solution

450 ml$60.00

RN-1456-L-AB39(0.1 M Iodine/Pyridine/H2O/THF)

2L$168.00

RN-1465-AB39*Thiophenol/Triethylamine/Dioxane

10 ml$38.00

RN-1535-L-AB39**Sulfurizing Reagent (Beaucage Reagent) for

2g$76.00$65.00Introduction of Phosphorothioate (S-oligonucleotide)RN-1688**** DDTT Solution

100 ml

RN-1688[0.05 M] (Sulfurizing Reagent)

200 ml$125.00			

450 ml$225.00

RN-1688
RN-1689**** DDTT Solution

100 ml$88.00			

RN-1689[0.10 M] (Sulfurizing Reagent)

200 ml$160.00			

450 ml$310.00

100 ml$8.00

BL-1536-M-AB39

250 ml$8.00

BL-1536-L-AB39

500 ml

$8.00

25 ml

$25.00

RN-1689
BL-1536-S-AB39

RN-1450-AB39

Silanized Bottles for Beaucage Reagent

AMA Reagent* Used in selective removal of p-methoxy groups in oligos.
** For the separate listing of Beaucage Reagent see page 175.
*** Moisture Content: less than 50 ppm. Bottles are prepacked with drying traps an extra moisture free environment.
**** For Bulk pricing and details of Solid DDTT (Sulfurizing Reagents) see page 175.

21

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Ancillary Reagents

Akta Oligonucleotide Synthesizers
Catalog #Product Name

Qty.

Price

RN-1447-S-OP

Acetonitrile Anhydrous

45 ml

$9.00

RN-1447-M-OP(Phosphoramidite Diluent & Washings)

100 ml$14.00450 ml$20.001L$32.00

RN-1447-L-OP
RN-1448-M-OP

Acetonitrile Wash Grade

RN-2202-M-OP

Cap A

4L

$90.004L$304.00			

4L$208.00			

4L$416.00			

4L$512.00			

4L$272.00		

4L$272.00			

(20% N-Methyl imidazole in Acetonitrile, v/v)
RN-2217-M-OP

Cap B1(40% Acetic Anhydride in Acetonitrile, v/v)

RN-2225-M-OP

Cap B2Modified DNA

RN-1448-L-OP

Standard DNA

Ancillary Reagents(60% Symmetrical Collidine in Acetonitrile, v/v)
*Activator (BMT)(5-Benzyl thio-1H-tetrazole; 0.2 M in acetonitrile)
RN-2238-M-OP

Oxidizer(50 mM Iodine in 10% Water/Pyridine)

RN-2242-M-OP

Deblock(3% DCA in Toluene, v/v)

Standard RNA* For the separate listing of BMT Reagent see page 173.

DNA Purification

RN-2232-M-OP

Modified RNA
RNA Purification
Antisense

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

22

Oligo Synthesis Products
Ancillary Reagents
Expedite Oligonucleotide Synthesizers

8909

8905

Catalog #Product Name

Qty.

Price

Qty.

Price

RN-1447-S-EX
RN-1447-M-EX
RN-1447-L-EX
RN-1448-M-EX
RN-1448-L-EX
RN-1551-SS-EX
RN-1551-S-EX
RN-1551-M-EX
RN-1551-L-EX
RN-1466-SS-EX
RN-1466-S-EX
RN-1466-M-EX
RN-1466-L-EX
RN-1467-SS-EX
RN-1467-S-EX
RN-1467-M-EX
RN-1467-L-EX
RN-1452

Acetonitrile Anhydrous(Phosphoramidite Diluent & Washings)

45 ml
100 ml450 ml
1L
4L
60 ml
200 ml450 ml2L
60 ml
200 ml450 ml2L
60 ml
200 ml450 ml
2L
45 ml

$9.00
$14.00$20.00$32.00$90.00$40.00$87.00$140.00$410.00$40.00$87.00$140.00$410.00$40.00$87.00$140.00$410.00$35.0045 ml
100 ml450 ml1L
4L
200 ml450 ml2L
200 ml450 ml2L
200 ml450 ml
2L
-		

$9.00
$14.00$20.00$32.00$90.00$87.00$140.00$410.00$87.00$140.00$410.00$87.00$140.00$410.00
-

60 ml
90 ml
450 ml
2L
60 ml
90 ml
450 ml
2L
60 ml
90 ml
450 ml2L
180 ml900 ml180 ml900 ml60 ml
200 ml450 ml200 ml450 ml2L
10 ml
100 mg
1g
2g
100 ml200 ml450 ml100 ml200 ml450 ml100 ml
250 ml500 ml$17.00$19.00$54.00$230.00$17.00$19.00$54.00$260.00$17.00$19.00$54.00$260.00$25.00$85.00$15.00$85.00$10.00$20.00$40.00$20.00$40.00$168.00$38.00$15.00$42.00$76.00$65.00$125.00$225.00$88.00$160.00$310.00
$8.00
$8.00
$8.00

200 ml450 ml2L
200 ml450 ml2L
200 ml450 ml2L
180 ml900 ml180 ml900 ml60 ml
200 ml450 ml
10 ml
100 mg
1g
2g
100 ml
250 ml500 ml$25.00$54.00$230.00$25.00$54.00$230.00$25.00$54.00$230.00$25.00$85.00$15.00$85.00$10.00$20.00$40.00$38.00$15.00$42.00$76.00
-		
-		
-		
$8.00
$8.00
$8.00

25 ml

$25.0025 ml$25.00

RN-1458-SS-EX
RN-1458-S-EX
RN-1458-M-EX
RN-1458-L-EX
RN-1481-SS-EX
RN-1481-S-EX
RN-1481-M-EX
RN-1481-L-EX
RN-7776-SS-EX
RN-7776-S-EX
RN-7776-M-EX
RN-7776-L-EX
RN-1468-M-EX
RN-1468-L-EX
RN-1462-M-EX
RN-1462-L-EX
RN-1455-S-EX
RN-1455-M-EX
RN-1455-L-EX
RN-1456-S-EX
RN-1456-M-EX
RN-1456-L-EX
RN-1465-EX
RN-1535-S-EX
RN-1535-M-EX
RN-1535-L-EX
RN-1688
RN-1688
RN-1688
RN-1689
RN-1689
RN-1689
BL-1536-S-EX
BL-1536-M-EX
BL-1536-L-EX
RN-1450-EX

Acetonitrile Wash Grade
Activation Reagent(0.45 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)

Activation Reagent(0.25 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)

Activation Reagent (DCI)(0.25 M 4,5-Dicyanoimidazole/Acetonitrile)

Activation Reagent (BMT)(0.3M 5-Benzylthio-1H-Tetrazole/Acetonitrile)
CAP A(Acetic Anhydride/Pyridine/THF)

CAP B(10% N-Methylimidazole/THF, v/v)

CAP B
(16% N-Methylimidazole/THF, v/v)

DMTr Removal Reagent(2.5% Dichloracetic Acid/Dichloromethane, v/v)
DMTr Removal Reagent(3% Trichloracetic Acid/Dichloromethane, v/v)
Oxidation Solution(0.02 M Iodine/Pyridine/H2O/THF)
Oxidation Solution(0.1 M Iodine/Pyridine/H2O/THF)*Thiophenol/Triethylamine/Dioxane**Sulfurizing Reagent (Beaucage Reagent) for
Introduction of Phosphorothioate (S-oligonucleotide)*** DDTT Solution[0.05 M] (Sulfurizing Reagent)*** DDTT Solution[0.10 M] (Sulfurizing Reagent)
Silanized Bottles for Beaucage Reagent

AMA Reagent* Used in selective removal of p-methoxy groups in oligos.
** For the separate listing of Beaucage Reagent see page 175.
*** DDTT Solution (Sulfurizing Reagents) see page 21,24 & 25.
*** For Bulk pricing and details of Solid DDTT (Sulfurizing Reagents) see page 175.

23

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Ancillary Reagents

Ancillary Reagents

MerMade Oligonucleotide Synthesizers
Catalog #Acetonitrile Wash Grade**** DDTT Solution[0.10 M] (Sulfurizing Reagent)
Silanized Bottles for Beaucage Reagent$54.00$109.00$54.00$109.00$54.00$109.00$47.00$85.00$27.00$85.00$40.00$135.00$50.00$135.00$38.00$15.00$42.00$76.00$65.00$125.00			
$225.00$88.00			$160.00			$310.00
$8.00
$8.00
$8.00
$25.00

RNA Purification

AMA Reagent

450 ml900 ml450 ml900 ml450 ml900 ml450 ml900 ml450 ml900 ml450 ml900 ml450 ml900 ml
10 ml
100 mg
1g
2g
100 ml200 ml450 ml100 ml200 ml450 ml100 ml
250 ml500 ml25 ml

Modified RNA**** DDTT Solution[0.05 M] (Sulfurizing Reagent)

Price
$9.00
$14.00$20.00$32.00$90.00$140.00$218.00$140.00$218.00$140.00$218.00$35.00Standard RNA

Activation Reagent(0.45 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)
Activation Reagent(0.25 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)
Activation Reagent(0.25 M 4,5-Dicyanoimidazole/Acetonitrile)
Activation Reagent (BMT)(0.3M 5-Benzylthio-1H-Tetrazole/Acetonitrile)
CAP A(Acetic Anhydride/THF/2,6-Lutidine)
CAP B(10% N-Methylimidazole/THF, v/v)
CAP B
(16% N-Methylimidazole/THF, v/v)
DMTrRemoval Reagent(2.5% DCA-Dichloracetic Acid/Dichloromethane, v/v)
DMTr Removal Reagent(3% TCA-Trichloracetic Acid/Dichloromethane, v/v)
Oxidation Solution(0.02 M Iodine/Pyridine/H2O/THF)
Oxidation Solution(0.1 M Iodine/Pyridine/H2O/THF)*Thiophenol/Triethylamine/Dioxane**Sulfurizing Reagent (Beaucage Reagent) for
Introduction of Phosphorothioate (S-oligonucleotide)

Qty.
45 ml
100 ml450 ml1L
4L
450 ml900 ml450 ml900 ml450 ml900 ml45 ml

DNA Purification

RN-1458-M-MR
RN-1458-L-MR
RN-1481-M-MR
RN-1481-L-MR
RN-7776-M-MR
RN-7776-L-MR
RN-1468-M-MR
RN-1468-L-MR
RN-1462-M-MR
RN-1462-L-MR
RN-1455-M-MR
RN-1455-L-MR
RN-1456-M-MR
RN-1456-L-MR
RN-1465-MR
RN-1535-S-MR
RN-1535-M-MR
RN-1535-L-MR
RN-1688
RN-1688
RN-1688
RN-1689
RN-1689
RN-1689
BL-1536-S-MR
BL-1536-M-MR
BL-1536-L-MR
RN-1450-MR

Product Name
Acetonitrile Anhydrous(Phosphoramidite Diluent & Washings)

Modified DNA

RN-1447-S-MR
RN-1447-M-MR
RN-1447-L-MR
RN-1448-M-MR
RN-1448-L-MR
RN-1551-M-MR
RN-1551-L-MR
RN-1466-M-MR
RN-1466-L-MR
RN-1467-M-MR
RN-1467-L-MR
RN-1452

Antisense* Used in selective removal of P-Methoxy groups in oligos.
** For the separate listing of Beaucage Reagent see page 175.
*** Moisture Content: less than 50 ppm. Bottles are prepacked with drying traps an extra moisture free environment.
**** For Bulk pricing and details of Solid DDTT (Sulfurizing Reagents) see page 175.

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

24

Oligo Synthesis Products
Ancillary Reagents
PolyPlex Oligonucleotide Synthesizers
Catalog #RN-1447-S-PX
RN-1447-M-PX
RN-1447-L-PX
RN-1448-M-PX
RN-1448-L-PX
RN-1551-M-PX
RN-1551-L-PX
RN-1466-M-PX
RN-1467-M-PX
RN-1452
RN-1458-M-PX
RN-1481-M-PX
RN-7776-M-PX
RN-1468-M-PX
RN-1462-L-PX
RN-1455-L-PX
RN-1456-M-PX
RN-1465-PX
RN-1535-S-PX
RN-1535-M-PX
RN-1535-L-PX
BL-1536-S-PX
BL-1536-M-PX
BL-1536-L-PX
RN-1688
RN-1688
RN-1688
RN-1689
RN-1689
RN-1689
RN-1450-PX

Product Name
Acetonitrile Anhydrous(Phosphoramidite Diluent & Washings)
Acetonitrile Wash Grade
Activation Reagent(0.45 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)
Activation Reagent(0.25 M 5-Ethylthio-1H-Tetrazole/Acetonitrile)
Activation Reagent(0.25 M 4,5-Dicyanoimidazole/Acetonitrile)
Activation Reagent (BMT Solution)(0.3 M 5-Benzylthio-1H-Tetrazole/Acetonitrile)
CAP A(Acetic Anhydride/Pyridine/THF)
CAP B(10% N-Methylimidazole/THF, v/v)
CAP B
(16% N-Methylimidazole/THF, v/v)
DMTr Removal Reagent(3% DCA (Dichloracetic acid)/Dichloromethane, v/v)
DMTr Removal Reagent(3% TCA (Trichloractic acid)/Dichloromethane, v/v)
Oxidation Solution(0.02 M Iodine/Pyridine/H2O/THF)
Oxidation Solution(0.1 M Iodine/Pyridine/H2O/THF)*Thiophenol/Triethylamine/Dioxane**Sulfurizing Reagent (Beaucage Reagent) for
Introduction of Phosphorothioate (S-oligonucleotide)
Silanized Bottles for Beaucage Reagent**** DDTT Solution[0.05 M] (Sulfurizing Reagent)**** DDTT Solution[0.10 M] (Sulfurizing Reagent)
AMA Reagent

Qty.

Price

45 ml
100 ml450 ml1L
4L
200 ml$9.00$14.00$20.00$32.00$90.00$87.00200 ml$87.00200 ml$87.0045 ml$35.00200 ml$25.00200 ml$25.00200 ml$25.002L$220.00

2L$108.00

200 ml$20.00200 ml$20.00

10 ml
100 mg
1g
2g
100 ml
250 ml500 ml100 ml200 ml450 ml100 ml200 ml450 ml25 ml$38.00$15.00$42.00$76.00
$8.00
$8.00
$8.00
$65.00$125.00			
$225.00$88.00			$160.00			$310.00$25.00* Used in selective removal of p-methoxy groups in oligos.
** For the separate listing of Beaucage Reagent see page 175.
*** Moisture Content: less than 50 ppm. Bottles are prepacked with drying traps an extra moisture free environment.

25**** For Bulk pricing and details of Solid DDTT (Sulfurizing Reagents) see page 175.

TollFree:Free:(800)(800)762-9323
762-9323
Toll

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

During the last couple of decades, pleathora of novel structurally modified nucleic acid analogs have been introduced1 to develop probes that has
potential application in nucleic acid based therapeutics2, diagnostics2, molecular biology3 & Nanotechnology4 research and development.
Incorporation of modified purines and pyrimidines has been utilized to optimize DNA-protein interactions and sequence recognition for many proteins and enzymes such as repressor proteins, restriction endonucleases, modification enzymes, and promoters5,6. Applications for a variety of key
modifications are described on the following pages.

Ancillary Reagents

Summary of Modified Deoxy Amidites & Supports

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis

ChemGenes carries a wide variety of modifed DNA phosphoramidites and supports. The products are summarized below.
Modified DNA
DNA Purification

4-Thio and 2-Thio amidites.
deoxy Inosine; deoxy Uridine; 5-Methyl cytidine Amidites and Supports.
C-5 Methyl substituted Amidites and Supports.
Alpha (α) deoxy Amidites and Supports.
2’-O-Trifluoroacetamido (TFA) propyl Amidite; 3’-amino (TFA) Amidites; 3’-amino (MMT) Amidites.
5’-amino (MMTr) thymidine Amidites and Supports.
Arabinoside Amidites and Supports.
7-Deaza Amidites; 7-Deaza-7-modified Amidites and Supports.
3’-deoxy adenosine (Cordycepin) Amidites and Supports.
6-Thio guanosine Amidites.
C-5; C8-Halogenated; 5’-Halogenated amidites and supports.

Standard RNA

N-Alkylated Amidites and Supports.
2’-Fluoro Insosine (O6-TMS-Ethyloxy) Amidites and Supports.
8-Methyl deoxy guanosine Amdites and Supports.
Nebularine; 2-Amino Purine Amidites and Supports

Nebularine, 2-Amino-purine-deoxyadenosine, & 2-Fluoro-deoxyinosine (O6-trimethoxy silyl ethoxy)
Modified RNA

4-Triazolyl; IsoC, IsoG Amidites and Supports
Including 2-Thio-thymidine, 2-Thio-deoxyuridine , Deoxy-isoguanosine, & Deoxy-isocytidine amidites & supports.

L-DNA Amidites and Supports
Abasic, 8-Oxo and Dideoxy Amidites and Supports
Including Abasic & Reverse Abasic, 8-Oxo-dA, 8-Oxo-dG, and Dideoxy-A,C,G,T amidites and supports.

RNA Purification

5’-O-Methyl DNA amidites
5’-O-DMTr-5-formyl (diacetyl)-2’-deoxyuridine-3’-CEP
References:

Antisense

1. Korreck. J. Eur. J. Biochem. 2003, 270, 1625.
2. Wilson, C. Curr. Opin . Chem. Biol. 2006, 5487-5502.
3. Grimm. D. Adv. Drug, Deliv. Rev. 2009, 61,672-703.
4. Lin, C. et. al. Biochemistry 2009, 48, 1663-1674.
5. Dubendorff, J. W.; de Hasett, P. L.; Rosendahl, M. S.; Caruthers, M. H. J. Biol. Chem. 1987, 262, 892.
6. Brennan, C. A.; Van Cleve, M. D.; Gumpert, R. I. J. Biol. Chem. 1986 261, 7270-7279.

26

Email: info@chemgenes.com

Chromophores &Ligands

www.chemgenes.com

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
2-Thio-thymidine-3’-CEP

2-Thio-2’-deoxyuridine-3’-CEP
Catalog#Catalog#O

O

ANP-9213O

ANP-9214

O

N

N
CH3

N

S

CH3
N

Pricing

DMTrO
O$620.00 / 250 mg

PN$1025.00 / 500 mg

OCE

2 Thio 3’-Succinyl lcaa Supports & Columns
Catalog #Product Name

100 mg

2-Thio-thymidine-500Å

N-9509-10

3’-lcaa CPG

1000Å

N-9510-05

2-Thio-2’-deoxyuridine-500Å

N-9510-10

3’-lcaa CPG

1000Å

$620.00 / 250 mg$1025.00 / 500 mg

OCE

Purity: 98% +C47H53N4O8PS
Mol. Wt.: 864.99

Pore Size

N-9509-05$280.00 / 100 μmole

O
P

N

Purity: 98% +C48H55N4O8PS
Mol. Wt.: 879.01

PricingO$280.00 / 100 μmole
O

S

DMTrO

Bulk CPG1g

0.2 µmole

$110

$810

$125

$900

4-Thio-thymidine-3’-CEP

pack of 4 cols.

0.2 µmole

$125

$155

$250

$310

$135

$170

$270

$340

Catalog#
NC

ANP-6414S

1.0 µmole

4-Thio-2’-deoxyuridine-3’-CEP
Catalog#NCpack of 10 cols.

1.0 µmole

ANP-7624

S
N

N
N

O

DMTrO
O

OCE

C43H52N5O7PS
Mol. Wt.: 813.94

O

Pricing

DMTrO
O$280.00 / 100 μmole$620.00 / 250 mg

O
P
N

N

Pricing$1025.00 / 500 mg

N

Purity: 98% +O
P$280.00 / 100 μmole$620.00 / 250 mg$1025.00 / 500 mg

OCE

Purity: 98% +C42H50N5O7PS
Mol. Wt.: 799.92

CAS No. 1290537-73-3

CAS No. 144303-74-2

3’-Succinyl lcaa Supports & Columns
Catalog #Product Name

Bulk CPG

pack of 4 cols.

pack of 10 cols.

Pore Size

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

$90

$735

$80

$120

$160

$240

$80

$735

$90

$120

$160

$240

N-9758-05

4-Thio-2’-deoxy-500Å

N-9758-10

uridine-3’-lcaa CPG

1000Å

N-9925-05

4-Thio-thymidine-500Å

N-9925-10

3’-lcaa CPG

1000Å

Thiolated Nucleobases

Thiolated nucleobases incorporated into oligonucleotides primarily have been used as an efficient photo-cross linking groups and useful moieties forfurther post-synthetic oligonucleotide modifications.1 Another high demand for thiolated nucleosides is in DNA and RNA structural study due to size andelectro negativity difference of the sulfur atom compared to oxygen.2
ChemGenes also offers thiolated RNA phosphoramidites (see p. 74)
1. Coleman, R. S., Kesicki, E. A. Jour. Am. Chem. Soc. 1994, 116, 11636. 2. Sismour, A. M., Benner, S. A. Nucleic. Acids Res. 2005, 33, 5640.

27

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis
2’-Deoxyuridine-3’-CEP
Catalog#

N

NH

PricingNN$115.00 / 250 mg$195.00 / 500 mg

P
OCE$95.00 / 250 mg

O
P OCE

N

Purity: 98% +C40H47N6O7P
Mol. Wt.: 754.81$32.00 / 100 μmoleO$165.00 / 500 mg

Purity: 98% +C39H47N4O8P
Mol. Wt.: 730.79

CAS No. 141684-35-7

CAS No. 109389-30-2

3’-Succinyl lcaa Supports & Columns
Catalog #Product Name

N-5107-05

Bulk CPG

Pore Size

2’-Deoxyuridine-3’-lcaa CPG

$45

$185

N-5107-20

2000Å
1000Å

$45

$185

N-5108-20

2000Å

5-Methyl-2’-deoxycytidine-3’-CEP

0.2 µmole

1.0 µmole		

$550

$60

$96

$120		

$60

$96

$120		

$48

		
$550

$48

5-Methyl-2’-deoxycytidine-3’-CEP(5-Methyl-2’-deoxycytidine (N-DMF )-3’-CEP)(5-Methyl-2’-deoxycytidine (N-Bz)-3’-CEP)

Catalog#
NHBz

ANP-6422

N

N

N
O

ANP-6421

N

N

Pricing

O

Pricing

DMTrO
O

DMTrO

$70.00 / 100 μmoleO$40.00 / 100 μmoleO$182.00 / 250 mg$325.00 / 500 mg

OCE

C43H55N6O7P
Mol. Wt.: 798.91

N

Purity: 98% +$100.00 / 250 mg

P$190.00 / 500 mg

OCE

RNA Purification

N

Modified RNA

Catalog#
NO
Ppack of 10 cols.

1.0 µmole 0.2 µmole

		

500Å

N-5108-10

pack of 4 cols.
5g

Standard RNA

1000Å
2’-Deoxyinosine-3’-lcaa CPG

1g

500Å

N-5107-10
N-5108-05

100 mgDNA Purification

Deoxy Inosine amidite: Universal bases hybridize non-selectively to each of native bases. For a recent publication in this field, see, Berger M., Wu Y., Ogawa A. K., McMinn D. L., Schultz P.
G., Rosenberg F. E., Nucl. Acids Res. 2000, 28, 2911-2914.

Purity: 98% +C47H54N5O8P
Mol. Wt.: 847.93

CAS No. 105931-57-5
Deprotection of Oligonucleotides consisting of 5-Methyl deoxy Cytidine (N-DMF) takes 3-4 hours at 37 °C with aq. ammonia and is compatible with PAC chemistry.

5-Methyl dC lcaa Supports & Columns
Product Name

Bulk CPG

Pore Size

N-1353-05

5-Methyl-2’-deoxycytidine (N-Bz)-

500Å

N-1353-10

3’-lcaa CPG

1000Å

N-1353-20

pack of 10 cols.

1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

$45

$175

$95

$135

$190

$270

$45

$175

$95

$135

$190

$270

		

2000Å
5-Methyl-2’-deoxycytidine (N-DMF)-

500Å

N-1355-10

3’-lcaa CPG

1000Å
2000Å

28

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

N-1355-05
N-1355-20

pack of 4 cols.

100 mgAntisense

Catalog #Modified DNA$45.00 / 100 μmole

O

PricingO

DMTrO

Modified DNA

O

ANP-6131

O

NH

DMTrO

N

Catalog#

ANP-6411

O
N

Ancillary Reagents

2’-Deoxyinosine-3’-CEPOligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
α-D-Modified DNA

DMTrO
O
B

O
P
N

OCE

B

Protection

Catalog#

A
C
G
T
C

N-Bz
N-Bz
N-iBu
N/A
N-Ac

ANP-1651
ANP-1652
ANP-1653
ANP-1654
ANP-4676

Catalog #Product Name

100 μmole

250 mg

500mg

1g

ANP-1651

α-D-2’-deoxyadenosine (N-Bz)3’-CEP, M.W. 857.93
α-D-2’-deoxycytidine (N-Bz)3’-CEP, M.W. 833.81
α-D-2’-deoxyguanosine (N-iBu)3’-CEP, M.W. 839.92
α-D-thymidine3’-CEP, M.W. 744.81
α-D-2’-deoxycytidine (N-Ac)3’-CEP, M.W. 771.84$70.00$175.00$295.00$500.00$70.00$175.00$295.00$500.00$70.00$175.00$295.00$500.00$70.00$175.00$295.00$500.00$70.00$175.00$295.00$500.00

ANP-1652
ANP-1653
ANP-1654
ANP-4676

α-D-5-methyl-2’-deoxycytidine (N-Bz)-3’-CEP
Catalog#
ANP1756

DMTrO
O
O
N

O
N

P
OCE

N

Pricing

NHBz$180.00 / 100 μmole$425.00 / 250 mg

C47H54N5O8P
Mol. Wt.: 847.93$725.00 / 500 mg

Purity: 98% +29

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Modified DNA SynthesisOOO

CPG-lcaa

B

α-D-2’-deoxyadenosine(N-Bz)-3’-lcaa CPG
α-D-2’-deoxycytidine(N-Bz)-3’-lcaa CPG
α-D-2’-deoxyguanosine(N-iBu)-3’-lcaa CPG

500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å

Catalog#

N-Bz
N-Bz
N-iBu
N/A

N-1751
N-1752
N-1753
N-1754

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

$45

$350

$100

$150

$200

$300

$45

$350

$100

$150

$200

$300

$45

$350

$100

$150

$200

$300 		

$45

$350

$100

$150

$200

$300

Standard RNA

α-D-thymidine3’-lcaa CPG

Pore Size

Protection

A
C
G
T

DNA Purification

N-1751-05
N-1751-10
N-1751-20
N-1752-05
N-1752-10
N-1752-20
N-1753-05
N-1753-10
N-1753-20
N-1754-05
N-1754-10
N-1754-20

Product NameB

Modified DNA

OCatalog #Ancillary Reagents

Solid Supports for Alpha-D-Modified DNA

DMTrO

Modified RNA
RNA Purification
Antisense

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

30

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
2’-O-Trifluoroacetoamidopropyl-cytidine-3’-CEP

2’-O-Trifluoroacetoamidopropyl-uridine-3’-CEP(2’O-Trifluoroacetoamido-propyl-cytidine (N-Bz)-3’-CEP)

Catalog#Catalog#O

ANP-7115

NH
N

P

N

H
N

O

CF3
O

OCE

C44H53F3N5O10P
Mol. Wt.: 899.89

O

DMTrO

PricingO

ANP-7116

N
N

O

DMTrO

O

NHBz

PricingO$275.00 / 100 μmole

O
P

H
N

O

$275.00 / 100 μmole

CF3$675.00 / 250 mg

NO$675.00 / 250 mg$1140.00 / 500 mg

C51H58F3N6O10P
Mol. Wt.: 1003.01$1140.00 / 500 mg

OCE

Purity: 98% +Purity: 98% +CAS No. 165381-49-7

CAS No. 165381-54-4

3’-Amino (TFA)-2’-deoxycytidine-5’-CEP

3’-Amino (MMTr)-thymidine-5’-CEP(3’-Amino (TFA)-2’-deoxycytidine (N-Bz)-5’-CEP)

Catalog#
NHBz
N
N
N

Catalog#O

ANP-1242
N

O
P
OCE
F3C

NH

PricingO

OCE
NHMMTrC39H48N5O6P
Mol. Wt.: 713.80$290.00 / 100 μmoleO
C27H34F3N6O6P
Mol. Wt.: 626.56

OO
P

PricingO

ANP-8454

NH
N

O$940.00 / 250 mg$290.00 / 100 μmole$940.00 / 250 mg$1590.00 / 500 mg$1590.00 / 500 mg

Purity: 98% +Purity: 98% +5’-Amino (MMTr)-thymidine-3’-CEP

3’-Amino (TFA)-2’-deoxyuridine-5’-CEP

Catalog#Catalog#

O

O
NH

N

ANP-9402
N
N

MMTrHNO

N

PricingO
P
OCE

C39H48N5O6P
Mol. Wt.: 713.8

ANP-1245

NH

O$145.00 / 100 μmole

O
P
OCE
F3C

O

Pricing

O
NH$290.00 / 100 μmoleO
C20H29F3N5O6P
Mol. Wt.: 523.44$395.00 / 250 mg$940.00 / 250 mg$710.00 / 500 mg$1590.00 / 500 mg

Purity: 98% +Purity: 98% +CAS No. 118849-12-0

3’-Succinyl lcaa Supports & Columns
Catalog #N-9506-05
N-9506-10

Product Name
5’-Amino (MMT)-thymidine3’-lcaa CPG

Bulk CPG

Pore Size
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$110

$850

$120

$180

$240

$360

		

31

Toll Free: (800) 762-9323
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Cytosine-arabinosideAra-(2’-O-acetyl)-adenosine (N-Bz)-3’-CEP

Ara-(2’-O-acetyl)-cytidine (N-Bz)-3’-CEP

Catalog#Catalog#

ANP-1712

ANP-1711
NHBz

NHBz

N

N

N
N

Pricing

N

AcO
O

DMTrO

OCE

N

$550.00 / 500 mg
C49H54N7O9P
Mol. Wt.: 915.97

OP$126.00 / 100 μmole$306.00 / 250 mg

OCE$550.00 / 500 mg

C48H54N5O10P
Mol. Wt.: 891.94

Purity: 98% +Modified DNA$306.00 / 250 mg

P

Pricing

O

N
AcO
O

DMTrO

$126.00 / 100 μmole

O
N

Ancillary Reagents

Adenosine-arabinoside

Purity: 98% +CAS No. 675573-97-4

Uridine-arabinoside

Guanosine-arabinosideAra-(2’-O-acetyl)-uridine-3’-CEP

Ara-(2’-O-acetyl)-guanosine (N-iBu)-3’-CEP

N
N

N

O
P

Pricing

PricingO$160.00 / 100 μmole

OCE

O

AcO
O

DMTrO

N

P

$126.00 / 100 μmole

OCE$306.00 / 250 mg

C41H49N4O10P
Mol. Wt.: 788.8$720.00 / 500 mg

Standard RNA$400.00 / 250 mg

C46H56N7O10P
Mol. Wt.: 897.95

ANP-1715

NH
N

NHiBu

AcO
O

DMTrO

O

ANP-1713

NH
N

DNA Purification

Catalog#Catalog#
O

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis$550.00 / 500 mg

Purity: 98% +Purity: 98% +Cytidine (N-Ac)-arabinosideAra-(2’-O-acetyl)-cytidine(N-Ac)-3’-CEP

ANP-1714

Pricing$126.00 / 100 μmole$306.00 / 250 mg

Modified RNA

Effect of all Arabino modified nucleosides on the duplex stabilities upon incorporation into DNA/RNA has been extensively studied.
(Beardsley, P.; Mikita, T.; Klause, M. M.; Nussbaum, A. L. Nucl. Acids. Res.
1988, 16, 9165).
AraC nucleoside is a potent antileukemic agent as well as an inhibitor of DNA
replication, through a mechanism which is not yet fully understood (Major, P. P.
et. al. Proc. Natl. Acad. Sci. USA, 1981, 78, 3235).

Catalog#$550.00 / 500 mg

Purity: 98% +Bulk CPG

Product Name

Pore Size

N-7366-05
N-7366-10
N-7366-20
N-7367-05
N-7367-10
N-7367-20
N-7421-05
N-7421-10
N-7421-20
N-7422-05
N-7422-10
N-7422-20

Ara-adenosine (N-Bz)3’-lcaa CPG

500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å

Ara-cytidine (N-Bz)3’-lcaa CPG
Ara-guanosine (N-iBu)3’-lcaa CPG
Ara-uridine3’-lcaa CPG

pack of 10 cols.

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

$65

$500

$88

$112

$176

$224

$65

$500

$88

$112

$176

$224

$65

$500

$88

$112

$176

$224

$65

$500

$88

$112

$176

$224

Antisense

Catalog#pack of 4 cols.

RNA Purification

Arabinoside lcaa Supports & Columns

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

32

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
2’-Deoxytubercidin 3’-CEP

7-Deaza-2’-deoxyinosine-3’-CEP(7-Deaza-2’-deoxyadenosine (N-Bz)-3’-CEP);

Catalog#Catalog#

ANP-1146

O

NHBz

NH
N
O

N

O
P

OCE

C41H48N5O7P
Mol. Wt.: 753.82

N

Pricing

DMTrO

Pricing

DMTrO

O$150.00 / 50 μmole$310.00 / 100 μmole$790.00 / 250 mg$1340.00 / 500 mg$2200.00 / 1 g

O
P

N

OCE

C48H53N6O7P
Mol. Wt.: 856.94

7-Deaza-2’-deoxyguanosine (N-Ac)-3’-CEP

7-Deaza-2’-deoxyguanosine (N-iBu)-3’-CEP

Catalog#Catalog#
ANP-4857

N

N

NH

N

O
P

N

NHiBu

OCE

C45H55N6O8P
Mol. Wt.: 838.93

N

NHAc

Pricing

DMTrO

PricingO

ANP-4858

O

NH

DMTrO

O

$150.00 / 50 μmole$310.00 / 100 μmole$790.00 / 250 mg$1340.00 / 500 mg$2200.00 / 1 g

N

O
P

OCE

C43H51N6O8P
Mol. Wt.: 810.87

7-Deaza 3’-Succinyl lcaa Supports & Columns
N-8777-05
N-8777-10
N-8778-05
N-8778-10
N-8779-05
N-8779-10

Product Name

Pore Size$150.00 / 50 μmole$310.00 / 100 μmole$790.00 / 250 mg$1340.00 / 500 mg$2200.00 / 1 g

Purity: 98% +Purity: 98% +Catalog #$150.00 / 50 μmole$310.00 / 100 μmole$790.00 / 250 mg$1340.00 / 500 mg$2200.00 / 1 g

Purity: 98% +CAS No. 107134-59-8

Purity: 98% +O

ANP-4815

N
N

N

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole7-Deaza-2’-deoxyadenosine
500Å
$90(N-Bz)-3’-lcaa CPG;
1000Å
(2’-Deoxytubercidin CPG)
7-Deaza-2’-deoxyguanosine
500Å
$90(N-iBu)-3’-lcaa CPG
1000Å
7-Deaza-2’-deoxy500Å
$90
inosine-3’-lcaa CPG
1000Å

$750

$110

$145

$220
$290
				

$750

$110

$145

$220

$290

$750

$110

$145

$220

$290

7-Deaza-2’-deoxyadenosine (2’-deoxytubercidin), 7-Deaza-2’-deoxyGuanosine, and 7-Deaza-2’-deoxyInosine
These analogs of natural deoxy Inosine, deoxy Adenosine, and deoxy Guanosine have found great interest among molecular biologists for the purpose of localizing DNAenzyme interactions (Seela, F.; Driller, H. Nucl. Acids Res. 1985, 13, 911) and facilitating DNA sequencing using M13 chain-termination methodology (Mizusawa, S.; Nishimura,S.; Seela, F. Nucl. Acids Res. 1986 14, 1315).
The oligonucleotide containing these bases have reduced band compression which occurs due to strong GC base pairing. The high stability of the oligomers containing thesebases and their possible application in MALDI mass spectrometry (Schneider, K.; Chait, B. T. Nucl. Acids Res. 1995, 23, 1570) allows for these substances to play a key role
in DNA sequencing. The 7-deaza bases are related to 2’-deoxyadenosine, 2’-deoxyguanosine and form stable base pairs in duplex DNA. (Seela, F.; Winter, H. Helv. Chim.
Acta. 1994, 77, 597; Seela, F.; Winter, H. Helv. Chim. Acta. 1998, 81, 2244.)
For Corrosponding ribo 7-Deaza Amidites see page 80.
For Corrosponding 7-Deaza-2’-O-methyl amidites see page 96.

33

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7-Deaza-7-iodo-2’-deoxyadenosine-3’-CEP

Catalog#Catalog#(5’-DMTr-7-Deaza-7-Iodo-2’-deoxyguanosine (N-DMF )-3’-CEP)(5’-DMTr-7-Deaza-7-Iodo-2’-deoxyadenosine (N-DMF)-3’-CEP); 7-Iodo-2’-deoxytubercidin CEP

ANP-4589

O
I

N
I
N

NH N
N

N

N

N

Pricing

DMTrO
O

N

C44H53IN7O7P
Mol. Wt.: 949.81

PricingO$225.00 / 50 μmole$380.00 / 100 μmole$760.00 / 250 mg$1290.00 / 500 mg$2190.00 / 1 g

OCE

N

DMTrO

O
P

N

$225.00 / 50 μmole$380.00 / 100 μmole$760.00 / 250 mg$1290.00 / 500 mg$2190.00 / 1 g

OCE

C44H53IN7O6P
Mol. Wt.: 933.81

Purity: 98% +Purity: 98% +7-Deaza-2’-deoxyguanosine (N-DMF)7-propargylamino (TFA)-3’-CEP

Catalog#Catalog#

O

O

N
H

N

ANP-1339

N

F3C

N

NH

N

Pricing

DMTrO
O

P
OCE

C49H56F3N8O7P
Mol. Wt.: 956.99

N

N

N
N

DMTrO
O

O
P
N

OCE

C49H56F3N8O8P
Mol. Wt.: 972.99

Purity: 98% +Pricing$265.00 / 50 μmole$400.00 / 100 μmole$800.00 / 250 mg$1440.00 / 500 mg$2440.00 / 1 g

Modified RNA$265.00 / 50 μmole$400.00 / 100 μmole$800.00 / 250 mg$1440.00 / 500 mg$2440.00 / 1 gON

ANP-1354

O

N
H

N

Standard RNA

F3C

DNA Purification

7-Deaza-2’-deoxyadenosine (N-DMF)7-propargylamino (TFA)-3’-CEP

Modified DNA

O
P

ANP-4586

N

Ancillary Reagents

7-Deaza-7-iodo-2’-deoxyguanosine-3’-CEP

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis

Purity: 98% +7-Deaza-2’-deoxyguanosine (N-iBu)-3’-DMTr-5’-CEP
RNA Purification

Catalog#
ANP-4679
O
NH
N
N

N

NHiBu

O
P
OCE

O

$220.00 / 50 μmole$310.00 / 100 μmole$790.00 / 250 mg$1340.00 / 500 mg$2240 / 1 g

Chromophores &Ligands

ODMTr
C45H55N6O8P
Mol. Wt.: 838.93

Pricing

Purity: 98% +www.chemgenes.com
Email: info@chemgenes.com

Antisense

34

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
3’-Deoxyadenosine (N-Bz)-2’-CEP(Cordycepin)

Catalog#
ANP-9312

NHBz
N

N

N

N

Pricing

DMTrO
O$345.00 / 100μmole$895.00 / 250 mg$1520.00 / 500 mg$2420.00 / 1 g

O
P
N

OCE

C47H52N7O7P
Mol. Wt.: 857.93

Purity: 98% +CAS No. 207347-42-0

3’-dA lcaa Supports & Columns
Catalog #Bulk CPG

Product Name

N-9502-05

3’-Deoxyadenosine (N-Bz)2’-lcaa CPG (Cordycepin)
3’-Deoxyadenosine (N-Bz)2’-lcaa CPG (Cordycepin)

N-9502-10

pack of 4 cols.

pack of 10 cols.

Pore Size

100 mg0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

500Å

$295

$200

$400

$400

$800

1000Å

$295

$200

$400

$400

$800

6-Thio-2’-deoxyguanosine (N-Ac)-3’-CEP

CN

Catalog#

S
N
N

N
N

DMTrO

ANP-7628

O
N
H

CH3

O

N

O
P

Pricing
OCE

C45H55N8O7PS
Mol. Wt.: 883.01$250.00 / 100μmole$600.00 / 250 mg$1080.00 / 500 mg$1720.00 / 1 g

Purity: 98% +Halogenated Nucleobases
Brominated and iodinated nucleobases may be used in crystallographic studies of oligonucleotide structures,1 as photo-crosslinking groups orfor introducing other functional groups replacing halogen with nucleophiles.2 It has been shown that 5-modified pyrimidines such as 5-Fluor,
5-Bromo, 5-Iodo uridines and 5-Methyl cytidine capping increases nucleobase resistance from 7- to 12-fold over unmodified oligonucleotides.3
1.Goytisolo, F. A., Packman, L. C., Thomas, J. O. European J. Biol 1996, 242, 619, b) Fernandez, J. L., Campos, A., Goytisolo, F. A., Buno, I.,
Gosalvez, Jour. Biol. Cell 1994, 82, 33.
2.DeCorte, B. L., Tsarouhtsis, D., Kuchimanchi, S., Cooper, M. D., Horton, P., Harris, C. M., Harris, T. M. Chem. Res. Toxicol. 1996, 9, 630.
3.Sanghvi, Y. S., Hoke, G. D., Freier, S. M., Zounes, M. C., Gonzalez, C., Cummins, L., Sasmor, H., Cook, P. D. Nucleic Acids Res. 1993, 21,
3197.

35

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

5-Bromo-2’-deoxyuridine-3’-CEP

Catalog#
NHBz
Br
N
N

ANP-6141

NH
N

O

Pricing

DMTrO
O
O
P
OCE

C46H51BrN5O8P
Mol. Wt.: 912.8$55.00 / 100 μmole$135.00 / 250 mg$240.00 / 500 mg$430.00 / 1 g

DMTrO

PricingO
O
PN

ANP-6415O

OCE

C39H46BrN4O8P
Mol. Wt.: 809.68$55.00 / 100 μmole$135.00 / 250 mg$240.00 / 500 mg$430.00 / 1 g

Purity: 98% +Purity: 98% +CAS No. 142246-64-8

CAS No. 178925-43-4(5-Iodo-2’-deoxycytidine (N-DBF)-3’-CEP)

Catalog#ONH

Catalog#

ANP-4611

N

ANP-4591

N
I
N

O
N

DMTrO

Pricing

O

N

O
P

OCE

C39H46IN4O8P
Mol. Wt.: 856.6$55.00 / 100 μmole$135.00 / 250 mg$240.00 / 500 mg$430.00 / 1 g

OPricing

DMTrO
O
O
P

N

$125.00 / 100 μmole$250.00 / 250 mg$450.00 / 500 mg$810.00 / 1 g

OCE

C48H60IN6O9P
Mol. Wt.: 1022.9

Purity: 98% +5-Fluoro-2’-deoxyuridine-3’-CEP

5’-Iodo-thymidine-3’-CEP
Catalog#Catalog#

N

O

O
O
N

P

OCE

ANP-6151

O
F
NH

Pricing$125.00 / 100 μmole$416.00 / 250 mg$710.00 / 500 mg$1275.00 / 1 g

N

O

DMTrO
O

N

O
P

OCE

C39H46FN4O8P
Mol. Wt.: 748.7

Purity: 98% +Pricing$125.00 / 100 μmole$416.00 / 250 mg$710.00 / 500 mg$1275.00 / 1 g

Antisense

C19H30IN4O5P
Mol. Wt.: 552.3

RNA Purification

ANP-4613
NH

I

Modified RNA

Purity: 98% +CAS No. 178925-48-9

OStandard RNAN

DNA Purification

5-Iodo-2’-deoxycytidine (N-DBF)-3’-CEP

5-Iodo-2’-deoxyuridine-3’-CEP

I

Modified DNA

N

Catalog#
O
Br

Ancillary Reagents

5-Bromo-2’-deoxycytidine (N-Bz)-3’-CEP

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis

Purity: 98% +CAS No. 178925-48-9

For applications of halogenated nucleobases please refer to page # 35.

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

36

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
8-Bromo-2’-deoxyadenosine (N-DBF)-3’-CEP

8-Bromo-2’-deoxyadenosine (N-Bz)-3’-CEP(8-Bromo-2’-deoxyadenosine (N-DBF)-3’-CEP)(8-Bromo-2’-deoxyadenosine (N-Bz)-3’-CEP)

Catalog#Catalog#N

ANP-4702

NN

N

ANP-4703

N
N

DMTrO

N

O

N

DMTrO

Pricing

O

N

N
Br

N

Br

O
P

NHBz

OCE

C49H60BrN8O8P
Mol. Wt.: 999.93

N$110.00 / 100 μmole$275.00 / 250 mg$495.00 / 500 mg

O
PPricing
OCE$120.00 / 100 μmole$300.00 / 250 mg$540.00 / 500 mg

C47H51BrN7O7P
Mol. Wt.: 936.83

Purity: 98% +Purity: 98% +8-Bromo-2’-deoxyguanosine (N-iBu)-3’-CEP

Deprotection of Bz protected 8-Bromo deoxy Adenosine containing oligos takes 7-8hours at 37 °C with aq. ammonia.

Catalog#
ANP-6152

Deprotection of N-dibutyl formamidine (N-DBF) protected 5’-DMTr-8-Bromo deoxy
Adenosine takes 2-3 hours at 37 °C with aq. ammonia deprotection of oligo. This
group is compatabile with PAC Chemistry.

Pricing

C-8 Substituted Purine and C-5 Halogen Substituted
Pyrimidines:

O
N

NH

Br
N

N

NHiBu

DMTrO
O

N

O
P

OCE

C44H53BrN7O8P
Mol. Wt.: 918.81$100.00 / 100 μmole$230.00 / 250 mg$510.00 / 500 mg

The bromo group in Adenosine and Guanosine at C-8 position is photolabile innature. 8-Bromo deoxy Adenosine phosphoramidite has been incorporated into
synthetic DNA as a means to create a site which can be photo-activated after
duplex formation.

Purity: 98% +Such DNA or RNA probes containing 8-Bromo Adenosine or Guanosine could thus
be useful to determine specific contact in protein-DNA complexes (Liu, J., Verdine,
G. L. Tet. Lett. 1992, 33, 4265).

Supports for Halogenated Nucleosides
Catalog #Product Name

N-1378-05
N-1378-10

Bulk CPG

pack of 4 cols.

pack of 10 cols.

Pore Size

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

5-Bromo-2’-deoxyuridine-

500Å

$50

$175

$95

$145

$190

$290

3’-lcaa CPG

1000Å
$50

$175

$95

$145

$190

$290

$65

$260

$105

$160

$210

$320

$65

$260

$105

$160

$210

$320

$65

$260

$105

$160

$210

$320

$65

$265

$105

$160

$210

$320

$115

$430

$110

$180

$220

$360

$110

$420

$105

$175

$210

$350

$110

$420

$105

$175

$210

$350		

N-7362-05

5-Bromo-2’-deoxycytidine-500Å

N-7362-10(N-Bz)-3’-lcaa CPG

1000Å

N-7363-05

5-Iodo-2’-deoxycytidine-500Å

N-7363-10(N-DBF)-3’-lcaa CPG

1000Å

N-4612-05

5-Iodo-2’-deoxycytidine (N-Bz)

500Å

N-4612-10-3’-lcaa CPG

1000Å

N-7364-05

5-Iodo-2’-deoxyuridine-500Å

N-7364-10

3’-lcaa CPG

1000Å

N-7365-05

5-Fluoro-2’-deoxyuridine-500Å

N-7365-10

3’-lcaa CPG

1000Å

N-9921-05

8-Bromo-2’-deoxyguanosine

500Å

N-9921-10(N-iBu)-3’-lcaa CPG

1000Å

N-4704-05

8-Bromo-2’-deoxyadenosine

500Å

N-4704-10(N-DBF)-3’-lcaa CPG

1000Å

N-4705-05

8-Bromo -2’-deoxyadenosine

500Å

N-4705-10(N-Bz)-3’-lcaa CPG

1000Å

37

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis(N1-Methyl-2’-deoxyadenosine (N-Fmoc)-3’-CEP)

N1-Methyl-2’-deoxyguanosine-3’-CEP

Ancillary Reagents

N1-Methyl-2’-deoxyadenosine-3’-CEP(N1-Methyl-2’-deoxyguanosine (N-DMF)-3’-CEP)

Catalog#Catalog#
O

N

NFmoc
CH3
N

N

N

ANP-6121

N

N

N

DMTrO

O

Pricing

PricingO
O$325.00 / 100 μmole$690.00 / 250 mg$1170.00 / 500 mg

OCE

C56H60N7O8P
Mol. Wt.: 990.09

NP$325.00 / 100 μmole$825.00 / 250 mg$1470.00 / 500 mg

OCE

C44H55N8O7P
Mol. Wt.: 838.93

Purity: 98% +Modified DNA

N

ANP-6122

CH3

N

N

DMTrO

O
P

N

Purity: 98% +CAS No. 178925-48-9(N3-Methyl-2’-deoxycytidine (N-Bz))-3’-CEP)

N3-Methyl-thymidine-3’-CEP

Catalog#Catalog#

ANP-3851

NBz

ANP-6153

O
N
N

O

Pricing

DMTrO
O

N

O
P

Standard RNA

CH3

CH3
N
N

DNA Purification

N3-Methyl-2’-deoxycytidine-3’-CEP$225.00 / 100 μmole$630.00 / 250 mg$1070.00 / 500 mg

OCE

C47H54N5O8P
Mol. Wt.: 847.93

O

DMTrO
O
O
N

P

OCE

C41H51N4O8P
Mol. Wt.: 758.84

Purity: 98% +Pricing$127.00 / 100 μmole$286.00 / 250 mg$500.00 / 500 mg

Purity: 98% +Modified RNA

CAS No. 178925-48-9

N3-Cyanoethyl-thymidine-3’-CEP

O

CN

ANP-3857

N
N

O

DMTrO
O
O
P

OCE

C43H52N5O8P
Mol. Wt.: 797.88$150.00 / 100 μmole$495.00 / 250 mg$850.00 / 500 mg

Purity: 98% +Antisense

N

Pricing

DNA in living organisms is vulnerable to alkylation due to mutagenic effectsof carcinogens. Recently it has been shown that there is direct reversal of
N-alkylation of methylated bases in oligonucleotides. A recent discovery of an
enzyme which is a substrate for DNA repair (Trewick, S. C., Henshaw, T. F.,
Hausinger, R. P., Lindahl, T., Sedgwick, B. Nature, 2002, 419, 174-177; andanother report confirming these observations, Falnes, P.; Johansen, R. F.;
Seeberg, E. Nature 2002, 419, 178). These reports have great implication forrepair of such carcinogenic and mutagenic events*.
N-alkylated nucleosides and the oligonucleotides incorporating methylatedbases at specific sites in oligonucleotides possess great potential for studies
of reversal of alkylation in oligonucleotides and studies in oxidative alkylation
inside cells by various carcinogens.
ChemGenes is offering the phosphoramidites for studies and possibilities ofreversal of methylation lesions by use of oligonucleotides incorporating alkylated purine/pyrimidines.
*For more references check on page 39.

RNA Purification

N-Alkylated phosphoramidites
Catalog#

Check page # 39 for N-Alkylated nucleoside supports

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

38

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
N3-Ethyl-2’-deoxycytidine (N-Bz)-3’-CEP

N6-Methyl-2’-deoxyadenosine-3’-CEP
Catalog#Catalog#

ANP-3855

H3C
N

N

N

N
O

OCE

C41H50N7O6P
Mol. Wt.: 767.85

CH3
O

Pricing

DMTrO
O$150.00 / 100 μmole$415.00 / 250 mg$705.00 / 500 mg

O
NN

Pricing

N

DMTrO

P

ANP-3856

NBz

NH

N

O
P

$225.00 / 100 μmole$580.00 / 250 mg$990.00 / 500 mg

OCE

C48H56N5O8P
Mol. Wt.: 861.96

Purity: 98% +Purity: 98% +CAS No. 178925-48-9

N4-Ethyl-2’-deoxycytidine-3’-CEP
N4-Ethyldeoxy Cytidine phosphoramidite: N4-Ethyl dC hybridizes selectively
with natural dG to give G:4EtC base pair (Nguyen, H., Southern, E. M. Nucl.
Acids Res., 2000, 28, 3904-3909).

Catalog#
ANP-6444

N-Alkylated phosphoramidites references (cont. from page # 38):
Delaney, J. C., Essigmann, J. M. Proc. Natl. Acad. Sci. U.S.A. 2004, 101,
14051-14056.
Delaney, J. C. et. al. Nat. Struct. Mol. Biol., 2005, 12, 855-860.
Jarosz, D. F. et. al. Nature 2006, 439, 225-228.
Frick, L. E. et. al Proc. Natl. Acad. Sci. U.S. A. 2007, 104, 755-760.
Lee et. al. Biochemistry, 2009, 48, 1850-1861.
Jarosz, D. F. et. al. Proc. Natl. Acad. Sci U.S.A. 2009, 106, 21137-21142.
Li and et al, Journal of Nucleic Acids, 2010, 369434

NH

H3C

N
N

Pricing

O

DMTrO$190.00 / 100 μmole$550.00 / 250 mg$990.00 / 500 mg

O

N

O
P

OCE

C41H52N5O7P
Mol. Wt.: 757.85

Purity: 98% +CAS No. 195535-80-9

Supports for N-Alkylated Nucleosides
Catalog #Product Name

N-9980-05

1
N -Methyl-2’-deoxyadenosine

N-9980-10

Bulk CPG1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

500Å

$125

$970

$90

$125

$180

$250

$125

$970

$90

$125

$180

$250

$125

$970

$90

$125

$180

$250

$125

$970

$80

$120

$160

$240

1000Å

(N-DMF)-3’-lcaa CPG
3
N -Methyl-thymidine-

1000Å
1000Å

N-9923-05

3’-lcaa CPG
4
N -Ethyl-2’-deoxycytidine-N-9923-10

3’-lcaa CPG

1000Å

N-9981-10
N-9922-05
N-9922-10

pack of 10 cols.

100 mg(N-Fmoc)-3’-lcaa CPG
1
N -Methyl-2’-deoxyguanosine

N-9981-05

pack of 4 cols.

Pore Size

500Å
500Å
500Å

39

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

(For post synthetic modification of Guanosine-carbon-2)

Catalog#Catalog#Si

ANP-7702

O

N
N

N

PricingS

S

N
H

PricingO$280.00 / 100 μmole$650.00 / 250 mg$1170.00 / 500 mg

O
N

P

OCE

C52H76N7O7PS2
Mol. Wt.: 1034.39

Purity: 98% +Modified DNA

C45H58FN6O7PSi
Mol. Wt.: 873.04

N

DMTrO

$250.00 / 100 μmole$640.00 / 250 mg$1080.00 / 500 mg

OCE

NH

N

F

O
O
P

ANP-6445

O

N

N

DMTrO

N

Si

Ancillary Reagents

N2(Tert-butyldithiopropyl)-O6-TMS-ethyloxy-2’-deoxyinosine3’-CEP

2-Fluoro-O6-TMS-ethyloxy-2’-deoxyinosine-3’-CEP

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis

Purity: 98% +CAS No. 175730-60-6

phosphoramidite

Ph

Catalog#Catalog#

Ph
N

O

Ph

N

NHiBu

PricingO
OCH3

C55H62N7O9P
Mol. Wt.: 996.10

ANP-9276

O
N

N

O

P

O

N

DMTrO

N

Ph
N

Standard RNA

N

ANP-9277ONDNA Purification

O6-Diphenylcarbamoyl-N2-iBu-2’-deoxyguanosine-3’-CEP

O6-Diphenylcarbamoyl-N2-iBu-2’-deoxyguanosine-3’-methyl

N

N

NHiBu

Pricing

DMTrO
O$150.00 / 100 μmole$335.00 / 250 mg$600.00 / 500 mg$150.00 / 100 μmole$335.00 / 250 mg$600.00 / 500 mg

O
P
N

OCE

C57H63N8O9P
Mol. Wt.: 1035.13

Purity: 98% +Purity: 98% +Modified RNA

3’-Succinyl lcaa Supports & Columns
Product Name

N-9926-05
N-9926-10

Bulk CPG

pack of 4 cols.

pack of 10 cols.

Pore Size

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

2-Fluoro-2’-deoxyinosine

500Å

$125

$970

$100

$150

$200

$300

(O6-trimethylsilyl ethyl)-

1000Å

				

3’-lcaa CPG

RNA Purification

Catalog #2-Fluoro-O6-trimethylsilyl-ethyloxy-2’-deoxyinosine-3’-CEP (ANP-7702)

1. DeCorte, B. L., Tsarouhtsis, D., Kuchimanchi, S., Cooper, M. D., Horton, P., Harris, C. M., Harris, T. M. Chem. Res. Toxicol. 1996, 9, 630.
2. Cohena, S. E., Lewisa, C. A., Mooneyb, R. A., Kohanskic, M. A., Collinsc, J. J., Landickb, R., Walkera, G. C. Proc. Natl. Ac. Sci. USA, 2010,
107, 15517.

www.chemgenes.com
Email: info@chemgenes.com

Antisense

40

Chromophores &Ligands

2-Fluoro-2’-deoxyinosine incorporated oligonucleotides have been used for conversion into N2-alkyl-2’-deoxyguanosine moiety and used in
DNA repair or damage pathway study.1,2

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
8-Methyl-2’-deoxyguanosine(N-iBu)-3’-CEP
8-Methyl deoxy Guanosine Phosphoramidite

ChemGenes now offers 8-methyl dG and 8-methyl rG amidite for incorporation inoligonucleotides for conformational studies, stability & oligonucleotides engineering.
8-methyl dG containing oligonucleotides have been shown to conform remarkablestability to Z-conformation of DNA. Similiarly 8-methyl dG containing oligonucleotides have been shown to cause a conformational and helical switch to left handed
oligonucleotides.

Catalog#O
N
N

ANP-9274

NH

H3C
N

NHiBu

DMTrO
O

Pricing

ONP

1.Sugiyama, H., Kawai, K., Matsunaga, A., Fujimoto, K., Saito, I., Robinson, H.,
Wang, A.H., Nucl. Acids Res. 1996, 24, 7, 1272-1278.
2.Cherrak, I., Mauffret,O., Santamaria,F., Hocquet,A., Ghomi, B., Rayner,B.,
Fermandjian, S., Nucl. Acids Res. 2003, 6986-6995.

$320.00 / 100 μmole$790.00 / 250 mg$1340.00 / 500 mg

OCE

C45H56N7O8P
Mol. Wt.: 853.94

Purity: 99% +8-Methyl lcaa Supports & Columns
Catalog #Bulk CPG

Product Namepack of 4 cols.

pack of 10 cols.

Pore Size

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

$125

$970

$80

$125

$160

$240

N-9924-05

8-Methyl-2’-deoxyguanosine

500Å

N-9924-10(N-iBu)-3’-lcaa CPG

1000Å

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

41

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Modified DNA Synthesis(2-Amino-purine-2’-deoxyriboside (N-DMF)-3’-CEP)

Catalog#
N

N

N

ANP-9315-2
N

OCE

C40H47N6O6P
Mol. Wt.: 738.81

N
N

N

N

N

Pricing

DMTrO
O$110.00 / 100 μmole$330.00 / 250 mg$595.00 / 500 mg

NO
P$300.00 / 100 μmole$825.00 / 250 mg$1480.00 / 500 mg

OCE

C43H53N8O6P
Mol. Wt: 808.91

Purity: 98% +Purity: 98% +CAS No. 178925-28-5

CAS No. 178925-41-2

Modified DNA

O
P

ANP-7601

PricingO

N

Catalog#

N

DMTrO

Ancillary Reagents

2-Amino-2’-deoxypurine riboside-3’-CEP

2’-Deoxynebularine-3’-CEP(2’-Deoxy-purine-3’-CEP)

ANP-9315 with N-iBu protection has been discontinued.

6-Chloro-2’-deoxypurine riboside-3’-CEP

2,6-Diamino-2’-deoxypurine (N2, N6-diPAC)-3’-CEP

Catalog#

N
N

N

N
N

NHPAC

Pricing

N

C56H61N8O10P
Mol. Wt.: 1037.11

Pricing

DMTrO
O$300.00 / 100 μmole$500.00 / 250 mg$850.00 / 500 mg

OCE

N
N

$250.00 / 100 μmole$720.00 / 250 mg$1290.00 / 500 mg

O
N

P

OCE

C40H46N6O6ClP
Mol. Wt.: 773.26

Purity: 98% +Purity: 98% +CAS No. 156549-50-7

Product Name

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmole

$110

$650

$80

$120

$160

$240

$110

$750

$120

$140

$240

$280

$110

$700

$90

$120

$180

$240

$110

$700

$90

$120

$180

$240

N-9511-05

2-Amino-2’-deoxypurine riboside500Å

(N-DMF)-3’-lcaa CPG

1000Å

N-9503-05

2’-Deoxynebularine500Å

N-9503-10-3’-lcaa CPG

1000Å

N-9512-05-DI

2-6-Diaminopurine-riboside500Å

N-9512-10-DI(N2,N6-diPAC)-3’-lcaa CPG

1000Å

N-9519-05

2-Amino-2’-deoxypurine500Å

N-9519-10

riboside 3’-lcaa CPG

1000Å

RNA Purification

Pore SizeN-9511-10

Modified RNA

3’-Succinyl lcaa Supports & Columns
Catalog #Standard RNA

O

N

ANP-7706

Cl

DMTrO

O
P

Catalog#

ANP-9316-DI

NHPAC

DNA Purification

2-Amino-2’-deoxyadenosine-(N2,N6-diPAC)-3’-CEP

Antisense

2,6-diminopurine
Oligonucleotides modified with diaminopurine display greater duplex stability and specificity compared to corresponding oligonucleotides
with adenosine. These oligonucleotides have potential application in the detection of single base mismatches in the target strands.1
1. Hughesman, C. B., Turner, R. F. B., Haynes, C. Nucleic Acids Symposium Series, 2008, 52, 245.

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

42

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
4-Triazolyl-2’-deoxyuridine-3’-CEP (Convertible dU)

4-Triazolyl-thymidine-3’-CEP (Convertible dT)
Catalog#Catalog#

N

N

N

ANP-9211

N

ANP-9212

N
N

N
N

N

O

N

Pricing

DMTrO
O
O
P

N

O

Pricing

DMTrO
O$130.00 / 100 μmole$320.00 / 250 mg$575.00 / 500 mg

OCE

C41H48N7O7P
Mol. Wt.: 781.84

NO
P$130.00 / 100 μmole$320.00 / 250 mg$575.00 / 500 mg

OCE

C42H50N7O7P
Mol. Wt.: 795.86

Purity: 98% +CAS No. 109389-31-3

2’-Deoxy-isoguanosine-3’-CEP

Purity: 98% +CAS No. 101712-10-1

2’-Deoxy-isocytidine-3’-CEP(2’-Deoxy-isoguanosine (N-DBF)-3’-CEP)(2’-Deoxy-isocytidine (N-DBF)-3’-CEP)

Catalog#Catalog#O

N
N
N

ANP-4268

N

N
O

PricingO

N

ANP-4269

N

DMTrO

O

DMTrO

O
P

N

NH
N

N

$170.00 / 100 μmole$415.00 / 250 mg$745.00 / 500 mg

OCE

C49H65N8O7P
Mol. Wt.: 909.06

N

O
P

Pricing$170.00 / 100 μmole$430.00 / 250 mg$770.00 / 500 mg

OCE

C48H65N6O7P
Mol. Wt.: 869.04

Purity: 98% +Purity: 98% +Deprotection of dibutyl-Formamidyl protected 2’-deoxy isoGuanosine takes
4-5 hours at 37 ºC with aq. ammonia deprotection of oligo.

IsoG & IsoC 3’-Succinyl lcaa Supports & Columns
Catalog #Bulk CPG

Product Namepack of 4 cols.

pack of 10 cols.

Pore Size

100 mg1g

0.2 µmole

1.0 µmole

0.2 µmole

$125

$970

$110

$175

$220

$350

$125

$970

$110

$175

$220

$350

N-9929-05

2’-Deoxy-isocytidine

500Å

N-9929-10(N-DBF)-3’-lcaa CPG

1000Å

N-9927-05

2’-Deoxy-isoguanosine

500Å

N-9927-10(N-DBF)-3’-lcaa CPG

1000Å

		

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

43

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

1.0 µmoleStandard DNA

Phosphoramidites
and Supports
for Modified
DNA Synthesis
Phosphoramidites
and Supports
for Modified
RNA Synthesis

Ancillary Reagents

3'-HQ-Amidobenzyl-2'-Deoxy Amidite
Protection

Catalog#A

N-Bz

ANP-8301

C

N-Ac

ANP-8306

C

N-Bz

ANP-8302

C

N-Bz

ANP-8307

G

N-iBu

ANP-8303

T

N/A

ANP-8305

U

N/A

ANP-8304

500mg$410.00$815.00$1,460.00

ANP-8306

3’-HQ-Amidobenzyl-2'-Deoxycytidine (N-Ac)5’-CEP, M.W. 766.79
3’-HQ-Amidobenzyl-2'-Deoxycytidine (N-Bz)5’-CEP, M.W. 830.88
5-Methyl 3’-HQ-Amidobenzyl-2'-Deoxycytidine (N-Bz)5’-CEP, M.W. 828.90
3’-HQ-Amidobenzyl-2'-Deoxyguanosine (N-iBu)5’-CEP, M.W. 820.88
3’-HQ-Amidobenzyl-2'-Thymidine
5’-CEP, M.W. 739.76
3’-HQ-Amidobenzyl-2'-Deoxyuridine
5’-CEP, M.W. 725.74$410.00$815.00$1,460.00$410.00$815.00$1,460.00$410.00$815.00$1,460.00$410.00$815.00$1,460.00$410.00$815.00$1,460.00$410.00$815.00$1,460.00

ANP-8307
ANP-8303
ANP-8305
ANP-8304

Standard RNA

250mg

3’-HQ-Amidobenzyl-2'-Deoxyadenosine (N-Bz)5’-CEP, M.W. 852.89

DNA Purification

100mg

ANP-8301

ANP-8302

Product Name

Modified
Modified DNA
DNA

Catalog #B

Modified RNA
RNA Purification

ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Chromophores &Ligands

Please Indicate Synthesizer when Ordering
Akta Oligopilot
AK

44

Email: info@chemgenes.com

Antisense

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com

Phosphoramidites
and Supports
for Modified
DNADNA
Synthesis
Phosphoramidites
and Supports
for Modified
Synthesis
β-L-DNA Amidites for Spiegelmers Synthesis

B
ODMTr
O
O
P
N

Catalog #ANP-8031
ANP-8032
ANP-8033
ANP-8034
ANP-8035
ANP-8036

OCE

B

Protection

Catalog#

CAS No.

A

N-Bz

ANP-8031

141846-54-0

C

N-Bz

ANP-8032

G

N-iBu

ANP-8033

141846-56-2

T

N/A

ANP-8034

141846-55-1

C

N-Ac

ANP-8035

U

N/A

ANP-8036

Product Name
β-L-2’-Deoxyadenosine (N-Bz)3’-CEP, M.W. 857.92
β-L-2’-Deoxycytidine (N-Bz)3’-CEP, M.W. 833.89
β-L-2’-Deoxyguanosine (N-iBu)3’-CEP, M.W. 839.90
β-L-Thymidine
3’-CEP, M.W. 744.80
β-L-2’-Deoxycytidine (N-Ac)3’-CEP, M.W. 771.84
β-L-2’-Deoxyuridine3’-CEP, M.W. 730.79

144385-59-1

100mg

250mg

500mg

1g

$160.00$320.00$510.00$810.00$1,250.00

2g$2,800.00

5g$160.00$320.00$510.00$810.00$1,250.00$2,800.00$160.00$320.00$510.00$810.00$1,250.00$2,800.00$160.00$320.00$510.00$810.00$1,250.00$2,800.00$160.00$320.00$510.00$810.00$1,250.00$2,800.00$160.00$320.00$510.00$810.00$1,250.00$2,800.00

Mirror Image of Natural DNA, (ß-L-Deoxy Nucleoside Phosphoramidites)
For The Synthesis of L-DNA• β-L-deoxyribonucleoside polymers do not form double strands with complementary strands (Aseline, U. et. al. Nucl. Acids. Res. 1991, 19, 4067-4074).
• β-L-deoxyribonucleosides have high resistance to digestion by various nucleases.
• Synthetic 56-nucleotide β-L-DNA bind with Vasopressin and is an antagonist of Vasopressin (Williams, K. P. et. al. Proc. Nat. Acad. Sci. USA 1997, 94, 1128511290).
• β-L-deoxyribonucleosides are being developed to bind with great specificity to antibodies and small biologically active molecules.
• β-L-DNA attached to primers for microarray design (Fig.1) and molecular beacon design (Fig 2).

Illustration of L-DNA for microarray design and attached molecular beacons:(a)Zip Code attached Primer(b)Standard Primer

Fig. 1. Template Specfic Primer Extension & Labelling Illustration of advantagesof L-DNA (Zip Code) attached Primers for PCR and Microarray (Nucl. Acids Res.
2007, 35, 7279-7287) Reproducid by the kind permission of Oxford Press, UK.

Fig. 2. Application of L-DNA attached molecular beacons (MB) avoiding non-specificbinding (a-c). Design of Universal Microarray Platform. (Nucl. Acids Res. 2006, 34,
5101-5111) Reproduced by the kind permission of Oxford Press, UK.

45

Toll Free:(800) 762-9323
Toll Free: (800)762-9323

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products

Standard DNA

Phosphoramidites
and Supports
for Modified
Synthesis
Phosphoramidites
and Supports
for Modified
DNA DNA
Synthesis

Ancillary Reagents

β-L-DNA lcaa Supports & Columns

B
ODMTr
O
O
lcaa-CPG
O

Protection

Catalog #A

N-Bz

N-3521C

N-Bz

N-3522G

N-iBu

N-3523Tn/aN-3524C

N-Ac

N-3525

Bulk CPG

Modified DNA

OBpack of 4 cols.

100 mg

500 mg1g

0.2 µmole 1.0 µmole

N-3521-10

ß-L-2’-Deoxyadenosine (N-Bz)-

500Å

$125

$290

$465

$120

3’-lcaa CPG

1000Å

N-3522-05

ß-L-2’-Deoxycytidine (N-Bz)-

500Å

N-3522-10

3’-lcaa CPG

1000Å

$125

$290

$465

N-3523-05

ß-L-2’-Deoxyguanosine (N-iBu)-

500Å

N-3523-10

3’-lcaa CPG

1000Å

$125

$290

N-3524-05

ß-L-Thymidine

500Å

N-3524-10

3’-lcaa CPG

1000Å

$125

N-3525-05

ß-L-2’-Deoxycytidine (N-Ac)-

500Å

N-3525-10

3’-lcaa CPG

1000Å

$125

Catalog #Product Name

Pore
Size

100

500

1

0.2

1.0

0.2

1.0

mg

mg

g

µmole

µmole

µmole

µmole

$125

$290

$465

$120

$240

$240

$480

1.0 µmole

$240

$240

$480

$120

$240

$240

$480

$465

$120

$240

$240

$480

$290

$465

$120

$240

$240

$480

$290

$465

$120

$240

$240

$480

pack of 4 cols.

pack of 10 cols.

Bulk CPG

N-4062-05

ß-L-3’-Deoxycytidine (N-Bz)-

500Å

N-4062-10

2’-lcaa CPG

1000Å

Modified RNA

N-3521-05

0.2 µmoleStandard RNA

Product NameDNA Purification

Pore
Size

pack of 10 cols.

Catalog #5-(1,2-Diacetyloxyethyl)-2’-deoxyuridine-3’-CEP
5-Formyl (diacetyl)-2’-deoxyuridine-3’-CEP

ANP-6067

OAc O
AcO

NH
N

DMTrO

N

O
P

O

Pricing

OCE$350.00 / 100 μmole$895.00 / 250 mg$1600.00 / 500 mg

C45H55N4O12P
Mol. Wt.: 874.91

1.
2.

Bjelland,S., Eide,L.,Time, R.W., Store,R., Eftedal,I., Volden,G., Seeberg,E.
Biochemistry 1995, 34,14758-14764.
Sugiyama, H., Matsuda, S., Kino, K., Zhang, Q-M., Yonei, S., Saito. I. Tet. Lett. 1996,
9067-9070.

Purity: 99% +CAS No. 186086-49-7

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Antisense

46

Chromophores &LigandsO

It has been shown that 5-Formyl-2’-deoxy uridine is formed in DNA as a result of ionization
radiation and several means such as gamma-ray irradiation and other oxidative damages1,2.
The damaged DNA, due to formation of 5-formyl uracil, causes mutagenises. We now offer
the 5-formyl dU-phosphoramidite for synthesis of DNA and modifications for the study andevaluation of various roles it plays and for diagnostic
applications.

RNA Purification

5- Formyl Uridine phosphoramidite

Catalog#

Reverse-Abasic-Phosporamidites; Reverse-dSpacer
Phosphoramidite (1,2-Dideoxy-D-ribose 3-O-DMTr-5-CEP)

AbasicPhosphoramidite; dSpacer Phosphoramidite(1,2-Dideoxy-D-ribose-3-CEP)

Catalog#
DMTrO

Catalog#

ANP-7058

ON

ANP-1422

O
P

O
P

N

O

OCE

Pricing

OCE

C35H45N2O6P
Mol. Wt.: 620

Pricing

ODMTr
C35H45N2O6P
Mol. Wt.: 620.72$95.00 / 100 μmole$330.00 / 250 mg$594.00 / 500 mg$125.00 / 100 μmole$425.00 / 250 mg$765.00 / 500 mg

Purity: 98% +Purity: 98% +CAS No. 129821-76-7

Abasic Site (dSpacer amidite)

Oligonucleotides containing the chemically stable isostructural tetrahydrofuran analog of an abasic site are important reagents for studies related to depurination ofoligonucleotides, which occurs quite frequently within the cell. For elegant publications regarding Tm values etc., see Pompizi, I., Haberli, A., Leumann, C. J. Nucl.
Acids Res. 2000, 28, 2702-2708, Aseline, U. et. al. Nucl. Acids Res. 1991, 4067-4074.

Abasic (dspacer) Succinyl lcaa Supports &Bulk CPG

pack of 4 cols.

pack of 10 cols.

Catalog #Product Name

Pore Size

100 mg0.2 µmole

1.0 µmole

0.2 µmole

1.0 µmoleN-1423-05
N-1423-10
N-1424-05
N-1424-10

1,2-Dideoxy-D-ribose
5-O-DMTr-3-lcaa CPG
1,2-Dideoxy-D-ribose
3-O-DMTr-5-lcaa CPG

500Å
1000Å
500Å
1000Å

$210

$170

$215

$340

$430

$290

$210

$300

$420

$600

8-Oxo-2’-deoxyguanosine-3’-CEP***

8-Oxo-2’-deoxyadenosine-3’-CEP(5’-O-DMTr-2’-deoxy-N-DMF-8-Oxo-guanosine-3’-CEP)(5’-O-DMTr-2’-deoxy-N-Bz-8-Oxo-adenosine-3’-CEP)

NHBz
H
N

N

O
N

N

Catalog#
ANP-9301

NH

ANP-9311-2

N
N

DMTrO

N

N

DMTrO

O

O

PricingO
P
N

Catalog#

O
H
N
O

OCE

C47H52N7O8P
Mol. Wt.: 873.93

PricingO$154.00 / 100 μmole$345.00 / 250 mg$620.00 / 500 mg

P$130.00 / 100 μmole$345.00 / 250 mg$620.00 / 500 mg

N

OCE

C43H53N8O8P
Mol. Wt.: 840.90

Purity: 99% +Purity: 98% +CAS No. 142979-42-8

3’-Succinyl lcaa Supports & Columns
Catalog #Product Name

Pore Size

100 mg

1g

N-5300-05
N-5300-10
N-9501-05
N-9501-10
N-9400-05
N-9400-10

8-Oxo-2’-deoxyadenosine(N-Bz)-3’-lcaa CPG
8-Oxo-2’-deoxyguanosine(N-DMF)-3’-lcaa CPG
8-Oxo-2’-deoxyguanosine(N-Ac)-3’-lcaa CPG

500Å
1000Å
500Å
1000Å
500Å
1000Å

$110

0.2 µmole

1.0 µmole

$780

$120

$125

$900

$125

$900

Bulk CPG

0.2 µmole

1.0 µmole

$145

$240

$290

$135

$170

$270

$340

$135

$170

$270

$340

pack of 4 cols.

pack of 10 cols.

***ANP-9311 With N-iBu protection has been discontinued.
47

Toll(800)
Free: (800)762-9323
Toll Free:762-9323

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites
and Supports
for Modified
DNADNA
Synthesis
Phosphoramidites
and Supports
for Modified
Synthesis

Standard DNA

Oligo Synthesis Products
Phosphoramidites
and Supports
for Modified
DNA Synthesis
Phosphoramidites
and Supports
for Modified
DNA Synthesis

NHBz
N

N

O
P
OCE

2’,3’-Dideoxycytidine (N-Bz)-5’-CEP

Catalog#N

DDN-7051

N

N
N

O

O
P
OCE

DDN-7052

O

O

Pricing

C25H34N5O5P
Mol. Wt.: 515.54$125.00 / 100 μmole$540.00 / 250 mg$950.00 / 500 mg$125.00 / 100 μmole$540.00 / 250 mg$950.00 / 500 mg

Purity: 98% +Purity: 98% +2’,3’-Dideoxy-thymidine-5’-CEP

Catalog#N

DDN-7053

NH
N

O

NHiBu

N

O
P
OCE

PricingO

C23H36N7O5P
Mol. Wt.: 521.55

DDN-7054

O

O
P

N

Catalog#

NH
N

Standard RNAN

DNA Purification

2’,3’-Dideoxyguanosine (N-iBu)-5’-CEP

O

Modified DNA

Pricing

C26H34N7O4P
Mol. Wt.: 539.57

Catalog#

NHBz

N

N

Ancillary Reagents

2’,3’-Dideoxyadenosine (N-Bz)-5’-CEP

O

OCE$200.00 / 100 μmole$800.00 / 250 mg$1440.00 / 500 mg

Pricing

C19H31N4O5P
Mol. Wt.: 426.4

Purity: 98% +Modified RNA$125.00 / 100 μmole$540.00 / 250 mg$950.00 / 500 mg

Purity: 98% +Catalog #Product Name

N-7368-05

2’,3’-Dideoxyadenosine(N-succinyl-lcaa CPG)
2’,3’-Dideoxycytidine(N-succinyl-lcaa CPG)

N-7369-05

pack of 4 cols.

pack of 10 cols.

Pore Size

100 mg

Bulk CPG1g

0.2 µmole

0.2 µmole

500Å

$250

$1,500

$180

$250

500Å

$250

$1,500$180$240

RNA Purification

Dideoxy Succinyl lcaa Supports & Columns

Chromophores &Ligands

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta OligopilotAKwww.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Antisense48

Oligo Synthesis Products
Phosphoramidites and Supports for Modified DNA Synthesis
5’-O-Methyl DNA Phosphoramidites

B
O
H3C

O
O
P
N

OCE

Catalog #Catalog#

CAS No.

N-Bz
N-Bz
N-iBu
N/A

ANP-5511
ANP-5512
ANP-5513
ANP-5514

149681-62-9

5’-O-Methyl-2’-deoxyadenosine (N-Bz)3’-CEP, M.W. 569.6
5’-O-Methyl-2’-deoxycytidine (N-Bz)3’-CEP, M.W. 545.6
5’-O-Methyl-2’-deoxyguanosine (N-iBu)3’-CEP, M.W. 551.58
5’-O-Methyl-thymidine3’-CEP, M.W. 456.47

ANP-5512
ANP-5513
ANP-5514

BN

100µmole

250mg

500mg

$250.00$966.00$1540.00$200.00$815.00$1310.00$200.00$815.00$1310.00$200.00$815.00$1310.00

100µmole

250mg

500mg

$155.00$295.00$495.00$155.00$295.00$495.00$155.00$295.00$495.00$155.00$295.00$495.00				

DNA 3’,5’-DiPhosphoramidites

O
P
OCE

O
O
P
N

ANP-7761

Protection

Product Name

ANP-5511

Catalog #

B
A
C
G
T

OCE

B

Protection

Catalog#

A
C
G
T

N-Bz
N-Ac
N-iBu
N/A

ANP-7761
ANP-7762
ANP-7763
ANP-7764

Product Name
3’,5’-Bis-CEP-2’-deoxyadenosine (N-Bz),

		

M.W. 755.78

ANP-7762

3’,5’-Bis-CEP-2’-deoxycytidine (N-Ac),
M.W. 669.69

ANP-7763

3’,5’-Bis-CEP-2’-deoxyguanosine (N-iBu),
M.W. 737.77

ANP-7764

3’,5’-Bis-CEP-thymidine,
M.W. 642.6

49

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

		

ANP-7681

ANP-7683
ANP-7766
ANP-7686

ANP-7681
ANP-7682
ANP-7683
ANP-7766
ANP-7686
ANP-7685

Product Name
2’-Deoxyadenosine (N-Bz)3'-Bis(diisopropylamino) Phosphoramidite,M.W. 888.06
2’-Deoxycytidine (N-Bz)3'-Bis(diisopropylamino) Phosphoramidite,M.W. 864.04
2’-Deoxyguanosine (N-iBu)3'-Bis(diisopropylamino) Phosphoramidite,M.W. 870.04
Thymidine3'-Bis(diisopropylamino) Phosphoramidite,M.W. 774.93
2’-Deoxycytidine (N-iBu)3'-Bis(diisopropylamino) Phosphoramidite,M.W. 830.02
2’-Deoxycytidine (N-Ac)3'-Bis(diisopropylamino) Phosphoramidite,M.W. 801.97

100µmole

250mg

500mg

$170.00$490.00$880.00$170.00$490.00$880.00$170.00$490.00$880.00$170.00$490.00$880.00$170.00$490.00$880.00$170.00$490.00$880.00

Standard RNA

ANP-7685

Catalog#

N-Bz
N-Bz
N-iBu
N/A
N-iBu
N-Ac

DNA Purification

ANP-7682

Protection

Modified DNA

Catalog #

B
A
C
G
T
C
C

Ancillary Reagents

DNA 3’-Bis(diisopropylamino) Phosphoramidite

Standard DNA

Phosphoramidites and Supports
for Natural DNA
Synthesis
DNA Purification& Drying
Traps

Modified RNA
RNA Purification
Chromophores &Ligands

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Antisense50

Oligo Synthesis Products
DNA Purification
DNA PURIFICATION

ChemGenes offers GENE-SYS 1 solid phase DMT-ON purification/extraction 96 well micropurifier to enable parallel purification of synthetic oligonucleotides for 5 OD (260nm) to 50 OD (260 nm) quantities. The 96 position GENE-SYS 1 accomodates the polypropylene
0.7 mL/well, 1.2 mL/well, 1.25 mL/well, and 2.25mL/ well removable well filter plates. The system charges crude oligos followed by washing and elution without a cumbersome valve network.
Catalog#
GS-3249
GS-1154
GS-1158
GS-8366
GS-3280
GS-3280
GS-8361

Product Name
Puri-Pak PlateTM
GeneSys-12 (Not Shown)
GeneSys-24 (Not Shown)
GeneSys Manifold for 96-Well Format GeneSys-1
96 Well Collection plate (1 plate)
96 Well Collection plate (Pack of 12)
96 Well Oligonucleotide Synthesis Plate

Prices$280.00$550.00$805.00$1,280.00$15.00$162.00$25.00GeneSys-12 (catalog #GS-1154) purifies up to 12 oligos at the same time.
GeneSys-24 (catalog #GS-1158) purifies up to 24 oligos at the same time.
Puri-Pak PlateTM (catalog #3249) is a 96-Well purification extraction plate. Each well is filled with a unique packing material for oligo
purication/cleanup. Each well is capable of the following:• DMT-ON purification of up to 1 μmole scale per well, or• DMT-OFF desalting of up to 25 OD per well
Genesys Manifold for the 96 Well format comes complete with a gasket for top and bottom collection plates. The system also includes
a vacuum controller for low vacuum evacuation of the system for the 96-well solvent, buffer exchange, and dropwise collection of thepurified oligo. This system has the advantage of simultaneous purification of large numbers of oligos in a 96-well purification format.
The purification of the crude synthetic oligos can be achieved either by desalting of the crude synthetic oligo or by DMT-ON purification
protocol of the crude synthetic DNA.
Besides the natural synthetic DNA oligonucleotides, the Puri-Pak Cartridges or the Puri-Pak plate can be used to purify terminal andnucleobase modified oligos, botin, other chromophore labeled oligos, 2’-O-Methyl-oligos, and phosphorothioate labeled oligos.
96-Well collection plates (catalog # GS3280) have a unique design in which the purification plate fits in effectively in each well for thecollection plate and accommodates a 2 ml volume per well.
Puri-Pak PlateTM and Puri-Pak CartridgesTM are trade marks of ChemGenes Corporation.

51

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Drying Traps

DNA moisture traps are used for maintaining moisture-free environments in oligonucleotide synthesis. The use of these traps will
generate super anhydrous conditions for high quality full length DNA/RNA. The traps are available in four different sizes: Small,
Medium, Large, and Extra Large. DNA moisture traps are shipped fully activated in vacuum sealed foil packets and are ready for
immediate use.

In addition, the use of these traps in the acetonitrile bottles wash cycle in the DNA synthesizer will maintain a dry environment which
results in consistently high coupling in the synthesis per cycle. The traps also restore the usability of “wet” acetonitrile (app. 250
ppm moisture content) by reducing the moisture content below 50 ppm.

Modified DNA

These traps allow highly effective drying of either phosphoramidite solution in acetonitrile, tetrazole solution in acetonitrile (activator
solution), or anhydrous acetonitrile (used to make either phosphoramidite solutions or activator solutions).

Ancillary Reagents

Drying Traps

Please see the data in the chart below for the selection of your specific application. As the chart indicates a small trap should be
used for 10 ml acetonitrile solution and a large trap should be used for 500 ml acetonitrile solution.

Shows the water absorption of the traps of different sizes, as determined by coulometric analysis of acetonitrile spiked with water.
Quantity of Acetonitrile

Amount of Moisture present
in “Wet” Solvent
180-200 ppm
180-200 ppm
180-200 ppm
180-200 ppm

One
One
One
One

Small
MediumLarge
Extra Large

Time required to achieve35-40 ppm or lower
24 Hours
24 Hours
24 Hours
24 Hours

Standard RNA

10-50 ml
50-100 ml
100-1000 ml
1-4 liters

Number of Traps required
Size of Trap
		

PricesSize

DMT-1975
DMT-1974
DMT-1973
DMT-1972

Small
MediumLarge
Extra Large

Price for 5

Price for 10$32.00$34.00$40.00$42.00$58.00$63.00$68.00$78.00Modified RNA

Catalog#

DNA Purification

Moisture Absorption Efficiency Chart:

RNA Purification
Antisense

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

52

Oligo Synthesis Products
DNA Purification & Drying Traps
Puri-Pak Cartridges & Barrels
The Puri-PakTM has been developed by ChemGenes to purify oligonucleotides by DMT-ON method and to desalt oligonucleotides whichhave been purified by ion-exchange HPLC or Gel Electrophoresis. They are very effective in producing high purity oligonucleotides after
synthesis.
The Puri-Pak cartridgesTM are suitable for the following applications:• Low scale and also 1.0 μmol scale purification of synthetic oligonucleotides, modified synthetic oligonucleotides carrying
amino-terminals, biotin, phosphorothioate oligonucleotides, and 2’-OMe oligonucleotides.
• Desalting of oligonucleotides.

Technical Details
The Puri-Pak columns are designed for efficient and fast purification of DMT-ON oligonucleotides as well as for desalting of oligonucleotides. They are recommended for single use where 25 OD units can be loaded per cartridge. The Puri-Pak columns can also efficiently
purify crude oligonucleotides. Also, 5’-DMT-ON oligonucleotides can be separated cleanly from the shorter “fail” sequences.
After NH3 deprotection of the oligonucleotide, the NH3 solution containing the dissolved oligo can be loaded directly onto the Puri-Pak
column. We recommend washing the crude oligo with Ether prior to removal of the cleaved base protecting groups. The oligo should
then be dissolved in either water or 0.1M triethylammonium acetate (1-3ml) and loaded onto the Puri-Pak column.

53

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

DNA Purification & Drying Traps
Quantity

Cartridge
Cartridge
Cartridge
Barrel (4 ml)
Barrel (4 ml)
Barrel (4 ml)
Barrel (8 ml)
Barrel (8 ml)
Barrel (8 ml)

1
5
10
1
5
10
1
10
50

Price
$6.50
$30.00$55.00$6.50$30.00$55.00$12.00$95.00$450.00

Modified DNA

Product Name

CSS-3920-S
CSS-3920-M
CSS-3920-L
CSS-3940-S
CSS-3940-M
CSS-3940-L
CSS-3960-S
CSS-3960-M
CSS-3960-L

Ancillary Reagents

Catalog#

DNA Purification
Standard RNA
Modified RNA
RNA Purification
Antisense

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

54

Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
RNA Synthesis
The importance of RNA has long been recognized in cellular processes. A major area of focus is on antisense RNA (Hëléne, C.; Toulme,
J. J. Biochim. Biophys. Acta 1990, 99, 1049) and the role of catalytic RNA in splicing and ligation (Cech, T. R. Science 1987, 236, 1532;
Guerrier-Takadac, N.; Altman, L. S. Science 1989, 246, 1578).
Chemical synthesis of defined sequence RNA is fundamental to develop and understand the role and application of RNA. The enzymatic
approach using RNA polymerase is template dependant and therefore, is not a controlled sequence synthesis (Milligan, J. F.; Groebe,
D. R.; Witherell, G. W.; Uhlenbeck, O. C. Nucl. Acids Res. 1987, 15, 8783).
Chemical synthesis of RNA has been perfected to the extent that long sequences, such as biologically active 76-mer tRNA and multimilligram quantities can be produced efficiently (Gasparuto, D.; Livache, T.; Bazin, H.; Duplaa, A.; Guy, A.; Khorlin, A.; Molko, D.; Roget,A.; Teoule, R. Nucl. Acids Res. 1992, 20, 5159; Webster, K. R.; Shamoo, Y.; Königsberg, W.; Spicer, E. K.; Biotechniques 1991, 11, 658).

Small Interference RNA

Small interference RNA (siRNA) is one of the key discoveries in the field of RNA application. Short double stranded RNAs (dsRNAs),
with a general chain length of 21-23 nts. and having a two nucleotide 3’-end overhang, mediate gene specific suppression of mammaliancells. siRNA guide endonucleolytic cleavage of the target RNA at a single site. The process is known as RNA interference (RNAi) (Fire,
A.; Xu, S.; Montgomery, M. K.; kostas. S. A.; Driver, S. E.; Mello, C. C. Nature 1998, 391, 806-811). The dsRNA direct the degradationof target RNAs complementary to the siRNA sequence (Zamore, P.; Tuschl, T.; Sharp, P.; Bartel, D. Cell 2000, 101, 25-33; Elbashir, S.;
Harborth, J., Weber, K.; Tuschl, T.; Methods Finds. Exp.Clin. Pharmacol. 2002, 26, 199-213).
The RNAi offers astronomical potentials for understanding and manipulating human diseases at the cellular level. Among the vast andrapidly exploding field of siRNA, some key developments in this area are prediction of natural regulatory mechanism in the field of cellbiology and functional genomics. This is expected to result in gene based drug discovery. Gene control, gene knock down, and target
validation are currently being persued with great vigor by a vast number of researchers worldwide.
Short dsRNA’s can be best obtained by Chemical synthesis. ChemGenes specializes in producing the highest purity RNA monomers forstudies and further developments in this field.

Use of ethylthio Tetrazole (ETT)The use of ethylthio tetrazole has been shown to enhance coupling efficiency to 99.7% (Wasner, M.; Arion, D.; Borkow, G.; Noronha, A.;
Uddin, A. H.; Parniak, M. A.; Damha, M. J. Biochemistry 1998, 37, 7478-7486).
Please see page 19-25 and 173 for ordering information.

Use of Benzylthio Tetrazole (BMT)The use of Benzylthio tetrazole as activator in RNA synthesis has been shown to yet further enhance coupling efficiency. (Wasner, M.;
Arion, D.; Borkow, G.; Noronha, A.; Uddin, A. H.; Parniak, M. A.; Damha, M. J. Biochemistry 1998, 37, 7478-7486).
Please see page 19-25 as Ancillary Reagent and page 173 for for bulk quantity supply for ordering information.

55

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

Ancillary Reagents

Quality Control Criteria for UltraPure RNA Phosphoramidites
31

P NMR

HPLC

151.299
149.299• Single or double peak
• Detection limit: 0.5%

Modified DNA• Single or double peak
• Detection Limit: 0.08%
85000
80000
75000
70000
65000
60000
55000
50000
45000
40000
35000
30000

DNA Purification

25000
20000
15000
10000
5000
0
-5000

76.02
23.98

230

220

210

200

190

180

170

160

150

140

130

120

110

100 90f1 (ppm)

80

70

60

50

40

30

31

P NMR of 5’-O-DMTr -2’-O-TBDMS Guanosine ((N-iBu) 3’-CEP

20

10

0

-10

-20

HPLC Graph of 5’-O-DMTr -2’-O-TBDMS Adenosin (N-Bz) 3’-CEP• Used to characterize the purine or pyrimidine structure and substituent

Standard RNA

UV Characterization

Coupling Test•

Greater than 98-98.5% stepwise coupling
efficiency under set conditions specified in thedata sheet supplied with compound

Modified RNA

UV Spectrum of 2’-O-TBDMS-ribo Cytidine (N-Bz)-OPUV Spectrum of 2’-O-TBDMS-ribo Cytidine (N-Bz)-OP

An example of a coupling efficiency
profile for an RNA Phosphoramidite

RNA Purification• Two spots in most cases, or a single spot
• Detection Limit 0.5%
• No visible impurity observed

Solubility Test

Antisense

Thin Layer Chromatography• 200 mg of pure dry product in 1.0 mL of dry acetonitrile(H2O Content < 0.004-0.005 g / 100 mL)

www.chemgenes.com
Email: info@chemgenes.com

Chromophores & Ligands

56Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
Amidites for Natural RNA Synthesis with Standard Base Protection
B
RO
O
O
P
N

Catalog#
ANP-5671
ANP-5672
ANP-5673
ANP-5674
ANP-4546
ANP-6676
ANP-4547
ANP-5678
ANP-5676
ANP-5677
ANP-5685
ANP-5688

O-TBDMS
OCE

R

B

Protection

Catalog#

CAS No.

DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
DMTr
MMTr
MMTr
MMTr
MMTr

A
C
G
U
A
C
G
G
A
G
C
U

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N-Ac
N-Ac
N-DMF
N-Bz
N-iBu
N-Bz
N/A

ANP-5671
ANP-5672
ANP-5673
ANP-5674
ANP-4546
ANP-6676
ANP-4547
ANP-5678
ANP-5676
ANP-5677
ANP-5685
ANP-5688

104992-55-4
118380-84-0
147201-04-5
118362-03-1

Product name2’-O-TBDMS-Adenosine (N-Bz)3’-CEP, M.W. 988.19
2’-O-TBDMS-Cytidine (N-Bz)3’-CEP, M.W. 964.17
2’-O-TBDMS-Guanosine (N-iBu)3’-CEP, M.W. 970.18
2’-O-TBDMS-Uridine3’-CEP, M.W. 861.05
2’-O-TBDMS-Adenosine (N-Ac)3’-CEP, M.W. 926.12
2’-O-TBDMS-Cytidine (N-Ac)3’-CEP, M.W. 902.10
2’-O-TBDMS-Guanosine (N-Ac)3’-CEP, M.W. 942.12
2’-O-TBDMS-Guanosine (N-DMF)3’-CEP, M.W. 955.16
MMTr-2’-O-TBDMS-Adenosine (N-Bz)3’-CEP, M.W. 958.17
MMTr-2’-O-TBDMS-Guanosine (N-iBu)3’-CEP, M.W. 940.15
MMTr-2’-O-TBDMS-Cytidine (N-Bz)3’-CEP, M.W. 934.14
MMTr-2’-O-TBDMS-Uridine3’-CEP, M.W. 831.02

121058-88-6
944138-03-8149559-87-5

111160-33-9

250mg

500mg

1g

2g

$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00$32.00$58.00$105.00$175.00

Bulk quantities available : 10g, 100g, 500g,1000g - Please enquire prices

Advantages and Applications of 5’-MMTr in Purine Bases for Oligo Synthesis
Due to the use of 5-ethylthiotetrazole (in most DNA/RNA Synthesis protocols), which is more acidic in nature compared to 1-H tetrazole, the DMTr group from purine bases
is removed to a certain extent in the coupling step during oligo synthesis, thereby causing undersired M+1 oligo growth.
Since the 5’-DMTr group in purine bases (A & G) cleave at much higher rate than 5’-MMTr group, the 5’-MMTr protected nucleoside phosphoramidites is preferable; thus,
offering a minimal level of M+1 impurities.

57

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

DMTrOO
O-TBDMS

O

O

B

Protection

Catalog #

A
C
G
U
C
A

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N-Ac

N-6101
N-6102N-6103N-6104N-6106N-6681

Bulk CPG

Pore Sizepack of 10 cols.

100

1

40

0.2

1.0

10

15

40

0.2

1.0

mg

g

nmole

µmole

µmole

µmole

µmole

nmole

µmole

µmole

$25

$240

$50

$60

$85

$240

$355

$100

$120

$170

$25

$240

$50

$60

$85

$240

$355

$100

$120

$170

$25

$240

$50

$60

$85

$240

$355

$100

$120

$170

$25

$240

$50

$60

$85

$240

$355

$100

$120

$170

$25

$240

$50

$60

$85

$240

$355

$100

$120

$170

$25

$240

$50

$60

$85

$240

$355

$100

$120

$170

Modified RNA

2’-O-TBDMSCytidine (N-Ac)3’-lcaa CPG
2’-O-TBDMSAdenosine (N-Ac)3’-lcaa CPG

500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å
500Å
1000Å
2000Å

each

Standard RNA

2’-O-TBDMSAdenosine (N-Bz)3’-lcaa CPG
2’-O-TBDMSCytidine (N-Bz)3’-lcaa CPG
2’-O-TBDMSGuanosine (N-iBu)3’-lcaa CPG
2’-O-TBDMS-Uridine3’-lcaa CPG

pack of 4 cols.

DNA Purification

N-6101-05
N-6101-10
N-6101-20
N-6102-05
N-6102-10
N-6102-20
N-6103-05
N-6103-10
N-6103-20
N-6104-05
N-6104-10
N-6104-20
N-6106-05
N-6106-10
N-6106-20
N-6681-05
N-6681-10
N-6681-20

Product Name

Modified DNA

lcaa-CPGOCatalog #Ancillary Reagents

Natural RNA Supports with Standard Base
Protection

B

RNA Purification

ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

Please Indicate Synthesizer when Ordering
Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores & Ligands

58Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
Amidites for Natural RNA Synthesis with Labile (Mild) Base
Protection
B
RO
O
O
P
N

Catalog #ANP-6671
ANP-6672
ANP-6673
ANP-6678
ANP-6677
ANP-6676
ANP-5679
ANP-6679
ANP-6680

O-TBDMS
OCE

R

B

DMTr
DMTr
DMTr
MMTr
MMTr
DMTr
DMTr
DMTr
DMTr

A
C
G
A
G
C
G
G
C

Product Name
2’-O-TBDMS-Adenosine (N-PAC)3’-CEP, M.W. 1018.22
2’-O-TBDMS-Cytidine (N-PAC)3’-CEP, M.W. 994.19
2’-O-TBDMS-Guanosine (N-PAC)3’-CEP, M.W. 1034.22
MMT-2’-O-TBDMS-Adenosine (N-PAC)3’-CEP, M.W. 988.19
MMT-2’-O-TBDMS-Guanosine (N-PAC)3’-CEP, M.W. 1004.19
2’-O-TBDMS-Cytidine (N-Ac)3’-CEP, M.W. 902.1
2’-O-TBDMS-Guanosine (N-Phenyl-Ac)3’-CEP, M.W. 1018.22
2’-O-TBDMS-Guanosine (N-iprPAC)3’-CEP, M.W. 1076.30
2’-O-TBDMS-Cytidine (N-tBPAC)3’-CEP, M.W. 1050.30

Protection
N-PAC
N-PAC
N-PAC
N-PAC
N-PAC
N-Ac
N-Phenyl-Ac
N-iprPAC
N-tBPAC

Catalog#

CAS No.

ANP-6671
ANP-6672
ANP-6673
ANP-6678
ANP-6677
ANP-6676
ANP-5679
ANP-6679
ANP-6680

121058-86-4
121058-87-5

121058-88-6

250mg

500mg

1g

2g

5g

$55.00$95.00$154.00$246.00$490.00$55.00$95.00$154.00$246.00$490.00$55.00$95.00$154.00$246.00$490.00$55.00$95.00$154.00$246.00$490.00$55.00$95.00$154.00$246.00$490.00$32.00$58.00$105.00$175.00$350.00$55.00$95.00$154.00$246.00$490.00$55.00$95.00$154.00$246.00$490.00$55.00$95.00$154.00$246.00$490.00

The capping reagent phenoxy acetic anhydride is recommended for capping during oligonucleotide synthesis and is available from ChemGenes, please see pages 19-25.
For a description of the advantages of using 5’-MMTr nucleoside phosphoramidites, please see page #55.

59

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

O
O

Ancillary Reagents

Natural RNA Supports with Labile (Mild) Base
Protection

B
DMTrO

O-TBDMSO

Protection

Catalog #

A
C
G
U
A
G

N-PAC
N-PAC
N-PAC
N/A
N-tBPAC
N-tBPAC

N-P6101
N-P6102
N-P6103
N-6104N-6207N-6208pack of 4 cols.

pack of 10 cols.

Catalog #Product Name

Pore Size

100

1
g

nmole

µmole

µmole

nmole

µmole

µmole

N-P6101-05
N-P6101-10
N-P6102-05
N-P6102-10
N-P6103-05
N-P6103-10
N-6104-05
N-6104-10
N-6207-05
N-6207-10
N-6208-05
N-6208-10

2’-O-TBDMS-Adenosine(N-PAC)-3’-lcaa CPG
2’-O-TBDMS-Cytidine(N-PAC)-3’-lcaa CPG
2’-O-TBDMS-Guanosine(N-PAC)-3’-lcaa CPG
2’-O-TBDMSUridine-3’-lcaa CPG
2’-O-TBDMS-Adenosine(N-tBPAC)-3’-lcaa CPG
2’-O-TBDMS-Guanosine(N-tBPAC)-3’-lcaa CPG

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

mg

40

0.2

1.0

40

0.2

DNA Purification

Bulk CPG

Modified DNA

lcaa-CPG
O

B

1.0

Standard RNA
Modified RNA
RNA Purification
Antisense

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

60

Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
Oxalyl RNA Supports with Labile Base (Mild) Protection for
RNA Synthesis

B
DMTrO
O
O

O-TBDMSO

O
lcaa-CPG

B
A
C
G
U
G

Protection
N-PAC
N-PAC
N-PAC
N/A
N-iBu

Bulk CPG

Catalog #N-5141-05
N-5142-05
N-5143-05
N-5144-05

Product Name

Pore Size

3’-Oxalyl-2’-O-TBDMSadenosine (N-PAC)-3’-lcaa CPG
3’-Oxalyl-2’-O-TBDMScytidine (N-PAC)-3’-lcaa CPG
3’-Oxalyl-2’-O-TBDMSguanosine (N-PAC)-3’-lcaa CPG
3’-Oxalyl-2’-O-TBDMSuridine-3’-lcaa CPG

Catalog #N-5141
N-5142N-5143N-5144N-5166pack of 4 cols.

pack of 10 cols.

100

1

40

0.2

1.0

40

0.2

1.0

mg

g

nmole

µmole

µmole

nmole

µmole

µmole

500Å

$48

$336

$70

$88

$106

$130

$166

$202		

500Å

$48

$336

$70

$88

$106

$130

$166

$202

500Å

$48

$336

$70

$88

$106

$130

$166

$202

500Å

$48

$336

$70

$88

$106

$130

$166

$202

Ammonia Free Oligo Deprotection Solution should be used under the following Conditions:
PAC-Protected nucleoside phosphoramidites must be used for efficient base deprotection using ammonia free oligo deprotection solution.
1. Oxalyl CPGs are cleaved using ammonia free oligo deprotection solution.
2. The standard succinyl CPGs will not adequately deprotect when using ammonia free oligo deprotection solution.
3. The oligonucleotide bound to solid support CPG after oligonucleotide synthesis is ether washed, air dried, and is placed in a vial with a septum cap.
4. Ammonia free oligo deprotection solution is added using a syringe. This reaction is typically done at 37°C for 24 hours.
Step by step protocol is provided with the COA.

Ammonia Free Oligo Deprotection Solution
Catalog#

Pricing

RN-1435$35.00 / 25 ml$55.00 / 50 ml$75.00 / 100 ml

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

61

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

2’-Acetal Levulinyl Ester (ALE), 5’-O-NPPOC for
Natural RNA Synthesis

B
O

O
O
O

O
O
P

Catalog #ANP-3212
ANP-3213
ANP-3214

CH3
OCE

O

Product Name
2’-O-ALE-5’-O-NPPOC-Adenosine (N-PAC)
3’-CEP, M.W. 936.90
2’-O-ALE-5’-O-NPPOC-Cytidine (N-iBu)
3’-CEP, M.W. 848.83
2’-O-ALE-5’-O-NPPOC-Guanosine (N-PAC)
3’-CEP, M.W. 952.90
2’-O-ALE-5’-O-NPPOC-Uridine
3’-CEP, M.W. 779.73

Protection

Catalog#

N-PAC
N-iBu
N-PAC
N/A

ANP-3211
ANP-3212
ANP-3213
ANP-3214

100mg

250mg

500mg

1g

$178.00$415.00$664.00$1,060.00$178.00$415.00$664.00$1,060.00$178.00$415.00$664.00$1,060.00$178.00$415.00$664.00$1,060.00

		

DNA Purification

ANP-3211

O

B
A
C
G
U

Modified DNA

NO

Ancillary Reagents

NO2 CH3

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

Standard RNA* ALE:Acetal Levulinyl Ester* NPPOC: 2-(2-Nitrophenyl) propyloxycarbonyl
2’-O-ALE-5’-O-NPPOC-Ribonucleoside Phosphoramides

Novel 2’-O-ALE (Acetal-Levulinyl-Ester)-5’-O-NPPOC phosphoramidites are now available for R & D in exciting field of RNA microarray technology. RNA synthesis utilizingthese monomers on a microarray (“chip”) has been successfully demonstrated (Lackey, J. G.; Mitra, D.; Somaza, M. M.; Cerrina, F.; Damha, M. J.; J. Am. Chem. Soc.
2009,131, 8496-8502).

Modified RNA
RNA Purification
Chromophores &Ligands

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Antisense

62

Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
2’-O-Pivom-RNA Phosphoramidites for Natural RNA Synthesis
B
DMTrO
O

B

OCE

A
C
G
U

O

O
P
N
Catalog #ANP-3216
ANP-3217
ANP-3218
ANP-3219

O
O

Protection

Product Name
2’-O-Pivom-5’-O-DMTr-Adenosine (N-PAC)3’-CEP, M.W. 1018.10
2’-O-Pivom-5’-O-DMTr-Cytidine (N-Ac)3’-CEP, M.W. 901.98
2’-O-Pivom-5’-O-DMTr-Guanosine (N-ipr-PAC)
3’-CEP, M.W. 1076.18
2’-O-Pivom-5’-O-DMTr-Uridine

Catalog#
ANP-3216
ANP-3217
ANP-3218
ANP-3219

N-PAC
N-Ac
N-ipr-PAC
N/A

250mg

500mg

1g

2g

5g

10g

$65.00$115.00$205.00$365.00$820.00$1,460.00$65.00$115.00$205.00$365.00$820.00$1,460.00$65.00$115.00$205.00$365.00$820.00$1,460.00$65.00$115.00$205.00$365.00$820.00$1,460.00

2’-O-PivOM-5-Methoxy-Uridine-3’-CEP* Pivom- Pivaloyloxymethyl
2’-O-Pivom-RNA Phosphoramidites

Catalog#
ANP-3781

Single step mild base deprotection of RNA synthesized by 2’-O-Pivom(Pivaloyloxymethyl) technology is very attractive and become as efficient as
DNA synthesis technology is now offering the 2’-O-Pivom amidites for R & D in
RNA synthesis field (Lavergne, T.; Janim, M.; Dupoug, C.; Vasseuer, J. J.; Debart, F.
‘‘Chemical synthesis of RNA with base Labile 2’-O-(Pivaloyloxy methyl) protected
Ribo nucleosides phosphoramidites’’ 2010, Curr Protoc Nucleic Acid Chem. Dec;
Chapter 3:Unit3.19).

Pricing$360.00 / 100 mg$810.00 / 250 mg$1290.00 / 500 mg

High Loading 5' Succinyl Polymeric Supports
for RNA Synthesis (loading greater than 150 μmol/g)

Catalog #PMS-6321-07
PMS-6322-07
PMS-6323-07
PMS-6324-07
PMS-6325-07

Product Name
2’-O-TBDMS-Adenosine (N-Bz)5’-succinyl Polymeric support
2’-O-TBDMS-Cytidine (N-Bz)5’-succinyl Polymeric support
2’-O-TBDMS-Guanosine (N-iBu)
5’-succinyl Polymeric support
2’-O-TBDMS-Uridine
5’-succinyl Polymeric support
2’-O-TBDMS-Cytidine (N-Ac)
5’-succinyl Polymeric support

B

Protection

Catalog #

A
C
G
U
C

N-Bz
N-Bz
N-iBu
N/A
N-Ac

PMS-6321
PMS-6322
PMS-6323
PMS-6324
PMS-6325

Pore
Size

Particle
Size

1

2

5

g

g

g

10
g

700-800Å

37-74 μm

$250

$390

$770

$1,220700-800Å

37-74 μm

$250

$390

$770

$1,220700-800Å

37-74 μm

$250

$390

$770

$1,220700-800Å

37-74 μm

$250

$390

$770

$1,220		

700-800Å

37-74 μm

$250

$390

$770

$1,22063

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Ancillary Reagents

Succinyl Polystyrene Supports for RNA
Synthesis
Protection

Catalog #

N-Bz
N-Bz
N-iBu
N/A
N-Ac

N-6211
N-6212
N-6213
N-6214
N-6216

Bulk Polystyrene
Loading 30-40 μmol/g

Catalog #N-6211-03

N-6213-03
N-6214-03

Pore
Size

Particle
Size

100

1

40

0.2

1.0

40

0.2

1.0

mg

g

nmole

µmole

µmole

nmole

µmole

µmole

300Å

60-70 μm

$35

$245

$50

$65

$80

$100

$130

$160

300Å

60-70 μm

$35

$245

$50

$65

$80

$100

$130

$160

300Å

60-70 μm

$35

$245

$50

$65

$80

$100

$130

$160

300Å

60-70 μm

$35

$245

$50

$65

$80

$100

$130

$160		

300Å

60-70 μm

$35

$245

$50

$65

$80

$100

$130

$160

ChemGenes has developed unique Polystyrene Supportsand columns that have special appeal due to rigidity, swelling, and inertness towards moisture and water.
Our supports have been checked for the synthesis of medium length oligos of varying sizes up to 40-mer.

PMS-7611-07
PMS-7612-07

PMS-7614-07
PMS-7615-07

2’-O-TBDMS-Adenosine (N-Bz)3’-succinyl Polymeric support
2’-O-TBDMS-Cytidine (N-Bz)3’-succinyl Polymeric support
2’-O-TBDMS-Guanosine (N-iBu)
3’-succinyl Polymeric support
2’-O-TBDMS-Uridine
3’-succinyl Polymeric support
2’-O-TBDMS-Cytidine (N-Ac)
3’-succinyl Polymeric support

Catalog #

N-Bz
N-Bz
N-iBu
N/A
N-Ac

PMS-7611
PMS-7612
PMS-7613
PMS-7614
PMS-7615

Pore
Size

Particle
Size

1

2

5

g

g

g

10

700-800Å

37-74 μm

$240

$380

$760

$1,210700-800Å

37-74 μm

$240

$380

$760

$1,210700-800Å

37-74 μm

$240

$380

$760

$1,210700-800Å

37-74 μm

$240

$380

$760

$1,210		

700-800Å

37-74 μm

$240

$380

$760

$1,210g

Chromophores &Ligands

PMS-7613-07

Product Name

Protection

A
C
G
U
C

RNA Purification

Catalog #B

Modified RNAHigh Loading 3' Succinyl Polymeric Supports
for RNA Synthesis (loading greater than 150 μmol/g)

Email: info@chemgenes.com

Antisense64

www.chemgenes.com

Standard RNA

N-6216-03

2’-O-TBDMS-Adenosine (N-Bz)3’-succinyl Polystyrene
2’-O-TBDMS-Cytidine (N-Bz)3’-succinyl Polystyrene
2’-O-TBDMS-Guanosine (N-iBu)
3’-succinyl Polystyrene
2’-O-TBDMS-Uridine
3’-succinyl Polystyrene
2’-O-TBDMS-Cytidine (N-Ac)
3’-succinyl Polystyrene

pack of 10 cols.

DNA Purification

N-6212-03

Product Namepack of 4 cols.

Modified DNA

B
A
C
G
U
C

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
RNA Methyl Phosphoramidites with Standard Base Protection
B
RO
O
O-TBDMS

O
P
N

OCH3

Catalog#

R

B

Protection

Catalog#

DMTr
DMTr
DMTr
DMTr
MMTr
MMTr

A
C
G
U
A
G

N-Bz
N-Bz
N-iBu
N/A
N-Bz
N-iBu

ANP-5691
ANP-5692
ANP-5693
ANP-5694
ANP-5696
ANP-5697

250mg

500mg

1g

2g

5g

10g

ANP-5691

2’-O-TBDMS-adenosine (N-Bz)3’-methyl-phosphoramidite, M.W. 949.16

Product name$45.00$680.00$140.00$250.00$630.00$1,130.00

ANP-5692

2’-O-TBDMS-cytidine (N-Bz)3’-methyl-phosphoramidite, M.W. 925.13
2’-O-TBDMS-guanosine (N-iBu)3’-methyl-phosphoramidite, M.W. 901.11
2’-O-TBDMS-uridine3’-P-O-methyl-phosphoramidite, M.W. 822.01
5’-O-MMTr-2’-O-TBDMS-adenosine (N-Bz)3’-methyl-phosphoramidite, M.W. 919.13
5’-O-MMTr-2’-O-TBDMS-guanosine (N-iBu)3’-methyl-phosphoramidite, M.W. 965.16$45.00$680.00$140.00$250.00$630.00$1,130.00$45.00$680.00$140.00$250.00$630.00$1,130.00$45.00$680.00$140.00$250.00$630.00$1,130.00$45.00$680.00$140.00$250.00$630.00$1,130.00$45.00$680.00$140.00$250.00$630.00$1,130.00

ANP-5693
ANP-5694
ANP-5696
ANP-5697

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

65

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

Ancillary ReagentsRNA Methyl Phosphoramidites with Labile (Mild) Base Protection

B
RO
O
O

O-TBDMSP
OCH3

Catalog #ANP-3862
ANP-3863
ANP-3866••

Catalog#

N-PAC
N-PAC
N-PAC
N-PAC
N-PAC

ANP-3861
ANP-3862
ANP-3863
ANP-3866
ANP-3867

Product Name
2’-O-TBDMS-adenosine (N-PAC)3’-methyl-phosphoramidite, M.W. 979.18
2’-O-TBDMS-cytidine (N-PAC)3’-methyl-phosphoramidite, M.W. 955.16
2’-O-TBDMS-guanosine (N-PAC)3’-methyl-phosphoramidite, M.W. 995.18
5’-O-MMTr-2’-O-TBDMS-adenosine (N-PAC)3’-methyl-phosphoramidite, M.W. 949.16
5’-O-MMTr-2’-O-TBDMS-guanosine (N-PAC)3’-methyl-phosphoramidite, M.W. 965.16

250mg

500mg

1g

2g

$90.00$175.00$335.00$645.00$1,550.00

5g$90.00$175.00$335.00$645.00$1,550.00$90.00$175.00$335.00$645.00$1,550.00$100.00$190.00$375.00$735.00$1,800.00$100.00$190.00$375.00$735.00$1,800.00

Standard RNA

ANP-3867

Protection

DNA Purification

ANP-3861

B
A
C
G
A
G

Modified DNA

N

R
DMTr
DMTr
DMTr
MMTr
MMTr

For natural phosphodiester oligonucleotide, use thiophenol solution (catalog#: RN-1465 on pages 19-25) to thoroughly remove the P-methoxy group prior toethanolic ammonia deprotection.
To make P-methoxy phosphotriester oligonucleotides, use our ammonia free deprotection solution listed on page 101.

Modified RNA
RNA Purification

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

Antisense

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

66

Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
Reverse RNA Amidites for RNA Synthesis Reverse Direction(5’→3’)B
N

P
OCE

Protection

A
C
C
G
U
G

O

DMTrO

Catalog #BO

O-TBDMS

Catalog#
ANP-3401
ANP-3402
ANP-3405
ANP-3403
ANP-3404
ANP-3406

N-Bz
N-Bz
N-Ac
N-iBu
N/A
N-iprPAC

Product Name

250mg

500mg

ANP-34012’-O-TBDMS-Adenosine (N-Bz)$41.00$72.005’-CEP, M.W. 988.19
ANP-3402
2’-O-TBDMS-Cytidine (N-Bz)$41.00$72.005’-CEP, M.W. 964.17
ANP-3405
2’-O-TBDMS-Cytidine (N-Ac)$41.00$72.005’-CEP, M.W. 902.10
ANP-3403
2’-O-TBDMS-Guanosine (N-iBu)$41.00$72.005’-CEP, M.W. 970.18
ANP-3404
2’-O-TBDMS-Uridine$41.00$72.005’-CEP, M.W. 861.05
ANP-3406
2’-O-TBDMS-Guanosine (N-iprPAC)$41.00$72.005’-CEP, M.W. 1076.30
Note: ANP-3406 has better solubility as compared to ANP-3403 in anhydrous acetonitrile.
Bulk quantities available : 10 g, 100 g, 500 g - Please enquire prices

1g

2g

5g

10g

$105.00$190.00$405.00$725.00$105.00$190.00$405.00$725.00$105.00$190.00$405.00$725.00$105.00$190.00$405.00$725.00$105.00$190.00$405.00$725.00$105.00$190.00$405.00$725.00

Supports for Reverse RNA Synthesis (5’→3’)
B

O

B
O

CPG-lcaa

O
O
DMTrO

O-TBDMS

Protection

A
C
C
G
U
G

Catalog #N-6201
N-6202N-6205N-6203N-6204N-6209

N-Bz
N-Bz
N-Ac
N-iBu
N/A
N-iPrPAC
Bulk CPG

Catalog #Product Name

N-6201-05
N-6201-10
N-6202-05
N-6202-10
N-6206-05
N-6206-10
N-6203-05
N-6203-10
N-6204-05
N-6204-10
N-6209-05
N-6209-10

2’-O-TBDMS-Adenosine(N-Bz)-5’-lcaa CPG
2’-O-TBDMS-Cytidine(N-Bz)-5’-lcaa CPG
2’-O-TBDMS-Cytidine(N-Ac) -5’-lcaa CPG
2’-O-TBDMS-Guanosine(N-iBu)-5’-lcaa CPG
2’-O-TBDMS-Uridine5’-lcaa CPG
2’-O-TBDMS-Guanosine(N-iprPAC) 5’-lcaa CPG

0.2

1.0

pack of 10 cols.

Pore Size

100

1
g

nmole

µmole

µmole

nmole

µmole

0.2

1.0

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

$25

$240

$50

$60

$85

$100

$120

$170

$25

$240

$50

$60

$85

$100

$120

$170

$25

$240

$50

$60

$85

$100

$120

$170

$25

$240

$50

$60

$85

$100

$120

$170

$25

$240

$50

$60

$85

$100

$120

$170

$25

$240

$50

$60

$85

$100

$120

$170

		mg

40

pack of 4 cols.
40

67

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502µmoleAncillary Reagents

Highlights of Reverse RNA Synthesis:(1-5)

Standard DNA

Phosphoramidites
andSupports
forforNaturalRNA
Synthesis
Phosphoramidites
andSupports
NaturalRNA
Synthesis
High Purity Synthetic RNA Synthesis in Reverse Direction (5’→3’)
Leads to Smooth 3’-conjugation of functional macromolecules to Synthetic RNA. Synthesized oligo’s are completely free of M+1 species.

Modified DNA
DNA Purification

Figure 2a.Capillary Gel Electrophoresis (CE) of the HPLC purified 21-mer
RNA with 3’-PEG (Poly ethyleneglycol; MW; 2000). Made by Reverse RNA
synthesis method (5’→3’-direction). Expedite model 8909- 1 µmole scale.
Purity; 100%

Figure 1. Capillary Gel Electrophoresis (CE) of 21-mer RNA with
3’-Cholesterol-TEG linker. Reverse direction (5’→3’) synthesis and
HPLC purification. 1 umole scale. Purity; 99.9%.

Standard RNA

Calculated Molecular Weight: 8684.1
Observed Molecular Weight: 8681.1

Figure. 2b. ESI /MS Spectral analysis of 21-mer RNA with 3’-PEG -2000 attachment.

Modified RNA

The synthesis in (5’→3’ direction). The PEG-2000 amidite (ChemGenes Cat# CLP-3119) as last step.

Note: There is a distribution of at least 14 PEG species of the RNA on both sides of the
Calculated molecular weight with PEG-2000. Thus species from 8417.1 to 8945.3 are present
with a molecular weight difference of a glycol unit (+/- 44).

Salient Features:

1. Srivastava, S.C., Srivastava, N.P., RNA Synthesis in the Reverse Direction, 2011, PCT Int. App., WO2011103468.
2. Srivastava, S.C., Srivastava, N.P., RNA Synthesis in the Reverse Direction, 2011, PCT App., Pub. US20110137010.

Chromophores &Ligands

References:

RNA Purification• Significant amount of (M-1) impurities are generated in the conventional method (3’→5’-direction).
• Insignificant amount of (M-1) impurities are generated in the reverse RNA synthesis (5’→3’ direction).
• The purified RNA synthesized by reverse RNA synthesis are high purity.
• The features mentioned above is much more evident in the synthesis of 3’-end cholesterol attached RNA. It is easier to purify RNA with cholesterol at 3’-end synthesized by reverse RNA synthesis.
• M+1 impurities are essentially absent in the RNAs synthesized by reverse RNA synthesis method. It is postulated that in the molecule, ribonucleoside 3’-O-DMTr-2’-O-TBDMS-5’-phosphoramidites, the 3’-O-DMTr group is not cleaved by 5-ethylthiotetrazole during the coupling timeof oligonucleotide chain extension.
• RNA containing macromolecules at the 3’-end which are generally inaccessible by conventional methods (3’→5’) are easily synthesized byreverse RNA synthesis (5’→3’ direction). These RNAs can be produced in high purity.
• 3’-PEG RNA (21-mer) was synthesized; after purification the oligonucleotide was essentially 100% pure.
• Shorter coupling time (~2 min) is used for Inverse RNA phosphoramidites coupling.

3. Srivastava, S.C., Pandey, D., Srivastava, N., Bajpai, S.P., RNA Synthesis in the Reverse Direction, 2010, WO2010027512.
4. Srivastava, S.C., Pandey, D., Srivastava, N., Bajpai, S.P., RNA Synthesis in the Reverse Direction, 2011, Current Protocols in Nucleic Acid Chemistry; Unit3.20.

www.chemgenes.com
Email: info@chemgenes.com

Antisense

68Oligo Synthesis Products
Phosphoramidites and Supports for Natural RNA Synthesis
TOM Amidites for RNA Synthesis, Labile Base Protection

B
DMTrO
O

B

Protection

Catalog#

CAS No.

OCE

A
C
G
U

N-Ac
N-Ac
N-Ac
N/A

ANP-3201
ANP-3202
ANP-3203
ANP-3205

253586-13-9253586-12-8253586-14-0
220230-62-6

O
P
N

O-TOM

Catalog #Product Name

250mg

500 mg

1g

5g

10g

ANP-32012’-O-TOM-Adenosine (N-Ac)
3’-CEP, M.W. 998.23
2’-O-TOM-Cytidine (N-Ac)3’-CEP, M.W. 974.18
2’-O-TOM-Guanosine (N-Ac)3’-CEP, M.W. 1014.15
2’-O-TOM-Uridine3’-CEP, M.W. 932.75

$55

$120

$245

$980

$1,630

$55

$120

$245

$980

$1,630

$55

$120

$245

$980

$1,630

$55

$120

$245

$980

$1,630

ANP-3202
ANP-3203
ANP-3205

TOM: Triisopropylsilyloxymethyl

2’-O-TOM-5-Methoxy-Uridine-3’-CEP
Catalog#
ANP-3799

Pricing$315.00 / 100 mg$700.00 / 250 mg$1260.00 / 500 mg

Purity: 99% +TOM RNA Supports with Labile Base Protection

B
DMTrO
O
O

O-TOM
lcaa-CPG

B

Protection

Catalog #

A
C
G
U

N-Ac
N-Ac
N-Ac
N/A

N-32001
N-32002
N-32003
N-32005

O
O
Bulk CPG

Catalog #Product Name

N-3201-05
N-3201-10
N-3202-05
N-3202-10
N-3203-05
N-3203-10
N-3205-05
N-3205-10

2’-O-TOM-Adenosine (N-Ac)3’-lcaa-CPG
2’-O-TOM-Cytidine (N-Ac)3’-lcaa-CPG
2’-O-TOM-Guanosine (N-Ac)3’-lcaa-CPG
2’-O-TOM-Uridine3’-lcaa CPG

pack of 4 cols.

pack of 10 cols.

Pore Size

100

1
g

nmole

µmole

µmole

nmole

µmole

µmole

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

$35

$245

$50

$65

$80

$100

$130

$160

$25

$240

$50

$60

$85

$100

$120

$170

		mg

40

0.2

1.0

40

0.2

69

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

1.0

2’-O-Triisopropylsilyl-oxy methyl amidites, produced under GMP guidelines.

Highly suitable for large scale therapeutic grade RNA synthesis, long RNA sequences, aptamers and biologically significant RNA
molicules.
ChemGenes has perfected technology to produce bulk quantities (100g to kilogram scale batches) of TOM amidites at good prices.

The following superior qualities makes TOM amidites desirable for therapeutic oligonucleotide production.

Modified DNA
DNA Purification• The synthesis resembles DNA Synthesis like couplig efficiency.
• Coupling efficiency consistently greater than 98% per step.
• Highest coupling efficiency per step, due to lower steric hindrance. Fast coupling time (2-4 minutes for differnt scale of synthesis), and complete
absence of 3’-impurities, either manufactured TOM amidites, 2’ to 3’-migration during oligo synthesis or during work up, results in high purity
oligonucleotiodes.
• Short deprotection time for N-protecting group with a time of 4-6 hours depending on chain length and with liberal amount of water. Labile Baseprotecting groups used are (N-Ac-A; N-Ac-C and N-Ac-G). Easy removal of TOM protecting group is achieved under mild condtions and in significantly excess amount of water without side effects.
• No formadehyde adduct formation occurs in the oligos made by using TOM amidite chemistry and after single Ion-Exchange purification, analyzed
by ESI/MS spectral data. None of the Mass spectral data showed peak corresponding to hydroxymethyl group (CH2-OH) either as single unit or
multiple units, mass corresponding to 30 or its multiples.
• Study of the quality of oligonucleotides synthesized using TOM amidites showed that the RNA oligos synthesized using TOM amidites were found
to result in far superior quality after single Ion-Exchange purification and analyzed by CE (capillary Gel) and ESI/MS.
• There is an overall time reduction using TOM amidite chemistry. All the steps, viz., base deprotection, TOM deprotection and ease of purification.
Besides high yield the process leads to high purity as well.

Ancillary Reagents

Highlights of TOM-Amidites in RNA Synthesis

Standard DNA

Phosphoramidites and Supports for Natural RNA Synthesis

Standard RNA

CE Analysis:Capillary gel (CE) Of HPLC Purified 12-mer
RNA (12µmole Scale) Using 2’-O-TOM amidites

Studies to Confirm Absence of Formaldehyde Adduct formation: During the loss of silyl and generation of formaldehyde and C-5

Modified RNA

formylation or N-formylation of nucleoside bases does not occur due to presence of aq. TRIS buffer, pH 7.4, which captures all the formaldehyde
formed and prevents any base modification as analyzed by ESI/MS spectral data. None of the Mass spectral data showed any peak corresponding
to hydroxymethyl group (CH2-OH) either as single unit or multiple units, with mass corresponding to 30 or its multiples (Fig.1a and Fig.1b).
adduct is seen (see the ESI/MS data)
ESI/MS data is presented here to substantiate clean RNA synthesis. No peak corresponding to the formaldehyde adduct (molecular ion + 30 Dalton)
has been detected.
It is likely that formaldehyde formed after the cleavage is captured by buffer, which is mildly basic, pH 7.4. Beacuse of nature of formaldehyde addition to pyrimidines (see Scheme below), pH 7.4 is recommended during desilylation step.

RNA Purification
Chromophores &Ligands

References :1. TOM Amidites are intellectual property of Qiagen Inc., Germantown, MD and licensed to ChemGenes Corp. for sales in Therapeutics RNA market.
2. Pitsch, S.; Weiss, P. A.; Jenny, L.; Stutz, A.; Wu, X. Helv. Chem. Acta. 2001, 84, 3773-3795.
3. TOM protecting group chemistry is covered by US Patent No. 5,986,084. ChemGenes Corp. holds license agreement with Qiagen Inc. for worldwide supply for Therapeutics market.

www.chemgenes.com
Email: info@chemgenes.com

Antisense70

Oligo Synthesis Products
Phosphoramidites and Supports for Modified RNA Synthesis
Summary of Phosphoramidites and Supports for Synthesis of Modified RNA
ChemGenes produces a wide range of modified RNA phosphoramidites and supports.
Our key modifications are summarized below:

Unnatural 2’,5’-Linkage amidites
N3-Methyl & N3-Thiobenzylethyl pyrimidine amidites

Includes N3-Methyl-uridine, N3-Methyl-ribothymidine & N3-Thiobenzoylethyl-uridine Amidites & Supports.

Inosine, ribo-Thymidine, 5-Methyl Cytidine and 2, 2’-Anhydro Uridine Amidites & Supports
N6-Substituted Purine Amitides & Supports

Includes N6-Benzyl-adenosine and N6-Isopentenyl-adenosine Amidites & Supports.

Puromycin (3’-deoxy N, N’-dimethyl-3’-[(O-methyl-L-tyrosyl)amino] adenosine) CPG
N4-Ethyl-Cytidine, 4-Thio-U and Pyrimidine-2-one (Zebularine) Products
2’-Fluoro and 2’-Amino Amidites & Supports

Includes 2’-Fluoro-C, 2’-Fluoro-U, 2’-Amino-C, 2’-Amino-U

2’-Amino-adenosine, Purine-riboside, & 2-Amino-purine-riboside
5-Halo pyrimidines & 8-Halo purine amidites & Supports

Includes 5-Bromo-cytidine, 5-Bromo-uridine, 5-Iodo-cytidine, 5-Iodo-uridine , 5-Fluoro-uridine, and 8-Bromo-adenosine

7-Deaza Amidites & Supports
7-Deaza-7-Modified Amidites & Supports
Iso-C and iso-G Amidites & Supports
2’,3’-O-Diacetyl-guanosine & Uridine
L-RNA Amidites & Supports

71

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Modified RNA Synthesis

Ancillary Reagents

B

Unnatural 2’,5’ Linkage RNA Amidites with Standard Base Protection

DMTrOO
TBDMS-O

Catalog#
ANP-5681

ANP-5683
ANP-5684
ANP-5686

ANP-5681
ANP-5682
ANP-5683
ANP-5684
ANP-5686
ANP-5687

Product name3’-O-TBDMS-Adenosine (N-Bz)2’-CEP, M.W. 988.19
3’-O-TBDMS-Cytidine (N-Bz)2’-CEP, M.W. 964.17
3’-O-TBDMS-Guanosine (N-iBu)2’-CEP, M.W. 970.18
3’-O-TBDMS-Uridine2’-CEP, M.W. 861.05
3’-O-TBDMS-Cytidine (N-Ac)2’-CEP, M.W. 902.10
3’-O-TBDMS-Inosine2’-CEP, M.W. 885.07

CAS No.

129451-77-0

250mg

500mg

1g

2g

5g

$80.00$150.00$290.00$510.00$1,140.00$80.00$150.00$290.00$510.00$1,140.00$80.00$150.00$290.00$510.00$1,140.00$80.00$150.00$290.00$510.00$1,140.00$80.00$150.00$290.00$510.00$80.00$150.00$290.00$510.00$1,140.00
Standard RNA

ANP-5687

Catalog#

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N/A

DNA Purification

ANP-5682

N

Protection

A
C
G
U
C
I

Modified DNA

CEO

O
P

B

$1,140.00

Modified RNA

For Supports, see page# 56*Currently we are offering 2’-O-TBDMS-Succinyl lcaa CPG Products instead of 3’-O-TBDMS-Succinyl lcaa CPG which we offered in the past.

Antisense

ChemGenes offers a wide variety of 3’-O-TBDMS protected ribonucleoside phosphoramidites that allow the synthesis of 2’-5’-linked oligos. The low molecular weightoligomer 5’-O-triphosphoryl adenylyl-(2’-5’)-adenylyl-(2’-5’)-adenosine (pppA2’p5’A2’p5’A) activates the latent endo-ribonuclease RNase L, which subsequently cleaves
the messenger and ribosomal RNAs (Charubala, R.; Uhlmann, E.; Himmelsbach, F.; Pfleiderer, W. Helv. Chem. Acta 1987, 70, 2028).
Such oligonucleotides are very useful to determine their exact biological role, to extend their biological half life, or to alter the biological activity of the core structure(A2’p5’A2’p5’A) (Jamoulle, J. C.; Imai, J.; Lesiak, K.; Torrence, P. F. Biochemistry, 1984, 23, 3063).
2’,5’-linked synthetic RNA sequences consisting of mixed bases and their duplexes are not substrates of the enzyme RNase H (Escherichia coli or HIV-1 reverse transcriptase). However, they can inhibit the RNaseH mediated cleavage of a natural DNA/RNA substrate (Wasner, M.; Arion, D.; Borkow, G.; Noronha, A.; Uddin, H. J.;
Parniak, M. A.; Damha, M. J. Biochemistry 1998, 37, 7478-7486).

RNA Purification

Synthesis of Unnatural RNA 2’-5’-linked Oligos

72

Email: info@chemgenes.com

Chromophores &Ligands

www.chemgenes.com

Oligo Synthesis Products
Phosphoramidites and Supports for Modified RNA Synthesis
N3-Methyl-2’-O-TBDMS-Uridine-3’-CEP

N3-Methyl-2’-O-TBDMS-RiboThymidine-3’-CEP

3(N3-Methyl-2’-O-TBDMS-ribo-thymidine-3’-CEP)(N -Methyl-2’-O-TBDMS-Uridine-3’-CEP)

Catalog#O
CH3O-TBDMS

O

O$160.00 / 100 μmole$410.00 / 250 mg$740.00 / 500 mg

P
N

OCE

C46H63N4O9PSi
Mol. Wt.: 875.07

O
N
N

Catalog#
ANP-7441

NH

ANP-6274

H3C
N

N

NHiBu

DMTrO
O

PricingO
O-TBDMSP
OCE

C54H69N4O10PSSi
Mol. Wt.: 1025.27

O$300.00 / 100 μmole$620.00 / 250 mg$1115.00 / 500 mg

Pricing
O-TBDMS$350.00 / 100 μmole$795.00 / 250 mg$1430.00 / 500 mg

P
N

OCE

C51H70N7O9PSi
Mol. Wt.: 984.20

Purity: 98% +Purity: 99% +3’-Succinyl lcaa Supports & Columns
N-9814-05
N-9814-10
N-9816-05
N-9816-10
N-9828-05
N-9828-10
N-9909-05
N-9909-10

Catalog#

O

O

DMTrO

O

Purity: 98% +8-Methyl-2’-O-TBDMS-Guanosine-3’-CEP

N

O$200.00 / 100 μmole$500.00 / 250 mg$900.00 / 500 mg

OCE

C47H65N4O9PSi
Mol. Wt.: 889.10

Purity: 98% +Ph

O-TBDMSP
N

N3-Thiobenzoylethyl-2’-O-TBDMS-Uridine-3’-CEP
S

Pricing

O

PricingO

Catalog #ANP-7461

O

N
DMTrO

DMTrO

N

CH3
N

ANP-7451

O

N

Catalog#O
H3C

N

Product Name
N3-Methyl-2’-O-TBDMSuridine-3’-lcaa CPG
N3-Methyl-2’-O-TBDMS-thymidine-3’-lcaa CPG
N3-Thiobenzoylethyl-2’-OTBDMS-Uridine-3’-lcaa CPG
8-Methyl-2’-O-TBDMSguanosine (N-iBu)-3’-lcaa CPG

Bulk CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$75

$475

$90

$120

$180

$240

$75

$475

$90

$120

$180

$240

$110

$475

$120

$165

$220

$340

$110

$475

$120

$165

$220

$340

N3-Methyl-uridine and N3-Methyl-thymidine are the results of chemical carcinogens on DNA/RNA. In general, alkylation products are formed at the
ring-nitrogen atoms and the exocyclic oxygen atoms of all four bases as well as at the oxygen atoms of the internucleotide phosphate bonds. Such
adducts can initiate neoplastic transformations (Singer, B., Kusmierek, J. T., Ann. Rev. Biochem. 1982, 52, 522; Saffhill, R., Margison, G. P., O’Connor,
P. J. Biochim. Biophys. Acta 1985, 823, 111).
The individual alkylation products are thought to possess different mutagenic and carcinogenic properties (Nucl. Acids Res. 1992, 20, 6471).
N3-Methyl-uridine phosphoramidite and N3-Methyl-thymidine phosphoramidite are currently available from ChemGenes for incorporation into RNA/DNA to further study the biochemical nature of these oligonucleotides. It is important to gain an understanding of these ring-nitrogen modified bases foreventual damage repairs.

73

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

(5’-O-DMTr-2’-O-TBDMS-thymidine-3’-CEP)

Catalog#

BzHN

Catalog#

O
H3C

H3C

N
N

NH

ANP-5675

ANP-7511

O

N

O

DMTrO

DMTrO

PricingO$120.00 / 100 μmole$290.00 / 250 mg$520.00 / 500 mg

O-TBDMSP
OCE

N

C53H68N5O9PSi
Mol. Wt.: 978.1

OCE

C46H63N4O9PSi
Mol. Wt.: 875.07

Purity: 98% +(5’-O-DMTr-2,2’-Anhydro-uridine-3’-CEP)O

Catalog#N

ANP-5680

ON

ANP-4876

N

DMTrO
DMTrO

O-TBDMSP
OCE

C46H61N6O8PSi
Mol. Wt.: 885.07$280.00 / 250 mg$450.00 / 500 mg$720.00 / 1 g

N

OCEC39H45N4O8P
Mol. Wt.: 728.77

Purity: 98% +Purity: 98% +3'-O-TBDMS-5-Methoxy Uridine-2’-CEP
Catalog#

ANP-3782

ANP-3783

Pricing

Pricing$360.00 / 100 mg$610.00 / 250 mg$1290.00 / 500 mg$330.00 / 100 mg$710.00 / 250 mg$1290.00 / 500 mg

Purity: 98% +Purity: 98% +

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$60

$475

$75

$110

$150

$210

$110

$545

$75

$90

$150

$180

$75

$425

$50

$65

$100

$130

$60

$485

$60

$75

$120

$150

Chromophores &Ligands

5-Methyl-2’-O-TBDMScytidine (N-Bz)-3’-lcaa CPG
2’-O-TBDMS-ribothymidine3’-lcaa CPG
2’-O-TBDMS-inosine3’-lcaa CPG
2,2’-Anhydro-uridine3’-lcaa CPG

Bulk CPG

Pore Size

RNA Purification

Product Name

Modified RNA

Catalog#

3’-Succinyl lcaa Supports & Columns
N-9822-05
N-9822-10
N-8477-05
N-8477-10
N-8370-05
N-8370-10
N-9810-05
N-9810-10$165.00 / 100 μmole$510.00 / 250 mg$920.00 / 500 mg

P

2'-O-TBDMS-5-Methoxy Uridine-3’-CEP

Catalog #Pricing

O

Standard RNA

NO

PricingO
O

DNA Purification

NH

Purity: 98% +2,2’-Anhydro-Uridine-3’-CEP
Catalog#O$185.00 / 100 μmole$480.00 / 250 mg$864.00 / 500 mg

PN(5’-O-DMTr-2’-O-TBDMS-inosine-3’-CEP)N

O-TBDMSO

2’-O-TBDMS-Inosine-3’-CEP

N

PricingO

Modified DNA

O

Ancillary Reagents

2’-O-TBDMS-RiboThymidine-3’-CEP

5-Methyl-2’-O-TBDMS-Cytidine-3’-CEP(5’-O-DMTr-5-Methyl-2’-O-TBDMS-cytidine (N-Bz)-3’-CEP)

Standard DNA

Phosphoramidites and Supports for Modified RNA Synthesis

www.chemgenes.com
Email: info@chemgenes.com

Antisense74

Oligo Synthesis Products
Phosphoramidites and Supports for Modified RNA Synthesis
N6-Benzyl-2’-O-TBDMS-adenosine-3’-CEP

N6-Isopentenyl-2’-O-TBDMS-adenosine-3’-CEP(N6-Benzyl-2’-O-TBDMS-adenosine-3’-CEP)

H
N

N

N

N
N

O-TBDMSP
OCE

C53H68N7O7PSi
Mol. Wt.: 974.21$365.00 / 100 μmole$790.00 / 250 mg$1260.00 / 500 mg

O
N

Catalog#N

ANP-4165$365.00 / 100 μmole$790.00 / 250 mg$1260.00 / 500 mg

P
OCE

Purity: 98% +N6,N6-Dimethyl-2’-O-TBDMS-adenosine-3’-CEP

H3C

Catalog#

CH3

N

O

ANP-8626

N

N

N

DMTrO

O

Pricing
O-TBDMSP
OCE

C47H66N5O8PSi
Mol. Wt.: 888.12

PricingO$265.00 / 100 μmole$594.00 / 250 mg$952.00 / 500 mg

O$365.00 / 100 μmole$840.00 / 250 mg$1340.00 / 500 mg

O-TBDMSPN

OCE
C48H66N7O7PSi
Mol. Wt.: 912.14

Purity: 98% +Purity: 98% +3’-Succinyl lcaa Supports & Columns
N-9824-05
N-9824-10
N-9050-05
N-9050-10
N-9060-05
N-9060-10

Pricing
O-TBDMSNOCatalog #ANP-8615

C51H70N7O7PSi
Mol. Wt.: 952.20

Purity: 98% +

H

DMTrO

N

N
N

N

N

Catalog#O

N4-Ethyl-2’-O-TBDMS-cytidine-3’-CEP

H3C

H

DMTrO

PricingO

N

ANP-8614

N

DMTrO

O

Catalog#
NN

Ph((N6-isopentenyl-2’-O-TBDMS-adenosine-3’-CEP)

Product Name
4
N -Ethyl-2’-O-TBDMScytidine-3’-lcaa CPG
N6-Benzyl-2’-O-TBDMSadenosine-3’-lcaa CPG
N6-Isopentyl-2’-O-TBDMSadenosine-3’-lcaa CPG

Bulk CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$ 60

$525

$85

$125

$170

$250

$120

$800

$105

$170

$210

$340

$125

$810

$110

$175

$220

$350

75

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites and Supports for Modified RNA SynthesisNC

4(1,2,4-Triazolyl)-2’-O-TBDMS-Uridine-3’-CEP

Catalog#S

Catalog#

N
N

N

N

ANP-8101N

ANP-9167

N

O
O

N

DMTrO

P
N

O

$350.00 / 100 μmole$840.00 / 250 mg$1510.00 / 500 mg

O-TBDMS
OCE

C48H64N5O8PSSi
Mol. Wt.: 930.1

Pricing

DMTrO$350.00 / 100 μmole$810.00 / 250 mg$1380.00 / 500 mg

O-TBDMSOP
N

OCE
C47H62N7O8PSi
Mol. Wt.: 912.

Purity: 98% +2’-O-TBDMS-Pyrimidin-2-one-3’-CEP; Zebularine CEP

Modified DNA

Pricing

O
O

Ancillary Reagents

4-Thiocyanoethyl-2’-O-TBDMS-Uridine-3’-CEP

Purity: 98% +DNA Purification

2-Thio-2’-O-TBDMS-Uridine (N3/O4-toluoyl)-3’-CEP
Catalog#Catalog#O

ANP-8611

N

ANP-9216

O
N

N

O
N

DMTrO

$240.00 / 100 μmole$630.00 / 250 mg$1130.00 / 500 mg

O-TBDMS

P
N

OCE

PricingOO$320.00 / 100 μmole$725.00 / 250 mg$1300.00 / 500 mg

O-TBDMSPN

OCE

C53H68N4O9SiPS
Mol. Wt.: 986.99

Purity: 98% +Purity: 98% +C45H61N4O8PSi
Mol. Wt.: 845.05

Standard RNA

O

DMTrO

PricingO

S

CAS No. 155831-90-6

Modified RNA

Puromycin 2’-succinyl lcaa CPG
N
N
N

N
N

DMTrO
O
TFAHN

H
NH
O

O
lcaa CPGORNA Purification

O
CH3O

N-1971-05/10
Succinyl lcaa Supports & Columns

N-9020-05
N-9020-10
N-4617-05

2’-O-TBDMS-Pyridine-2-One
3’-lcaa CPG (Zebularine CPG)
2’-O -TBDMS-Pseudouridine 3’-lcaa CPG
3’-O-Methyl-TyrosinePuromycin-2’-lcaa CPG

Pore Sizepack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

500Å
1000Å
500Å

$105

$685

$95

$145

$190

$290

$60

$525

$85

$125

$170

$250

500Å
1000Å

$108

$896

$108

$190

$216

$380

76

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

N-1971-05
N-1971-10

Product Namepack of 4 cols.

Antisense

Catalog #Bulk CPGOligo Synthesis Products

Phosphoramidites
and Supports
for Modified
RNA Synthesis
Phosphoramidites
and Supports
for Modified
RNA Synthesis

5'-DMT-2’-O-TBDMS-Pseudo-Uridine-3’-CEP

5'-DMT-2’-O-Methoxy -Pseudo Uridine-3’-CEP

Catalog#Catalog#

ANP-8612

ANP-3614

Pricing

Pricing$345.00 / 100 mg$995.00 / 250 mg$1790.00 / 500 mg$300.00 / 100 mg$700.00 / 250 mg$1290.00 / 500 mg

Purity: 98% +Purity: 98% +

O
NH

HN

O
DMTrO
O
O

O-TBDMSPN

OCE

C45H61N4O9PSi
Mol. Wt.: 861

CAS No. 163496-23-95'-DMT-2’-O-PivOM-N1-Methyl Pseudo-Uridine-3’-CEP

2'-O-TBDMS-Pseudouridine 3'- lcaa CPG

Catalog#
ANP-3619

Pricing$370.00 / 100 mg$830.00 / 250 mg$1490.00 / 500 mg

N-4617-05

Purity: 98% +Succinyl lcaa Supports & Columns
Catalog #N-4617-05

Product Name
2’-O -TBDMS-Pseudouridine 3’-lcaa CPG

Bulk CPG

Pore Size
500Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$60

$525

$85

$125

$170

$250

77

Toll Free:(800)
762-9323
Toll Free:(800)
762-9323

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNAs

Phosphoramidites
Supports
for Modified
Synthesis
Phosphoramidites
andandSupports
for Modified
RNARNA
Synthesis

DMTrO
O
O
P
N

F
OCE

Protection

Catalog#

CAS No.

A
A
C
G
G
U

N-Bz
N-DMF
N-Ac
N-iBu
N-DMF
N/A

ANP-9151
ANP-9157
ANP-9152
ANP-9153
ANP-9159
ANP-9154

136834-22-5

Product Name

ANP-9151
ANP-9157

ANP-9153
ANP-9159
ANP-9154

250mg

500mg

1g

2g

5g

2’-Fluoro-2’-deoxyadenosine (N-Bz)3’-CEP, M.W. 875.92
2’-Fluoro-2’-deoxyadenosine (N-DMF)3’-CEP, M.W. 826.9$115.00$205.00$320.00$526.00$1,055.00$125.00$225.00$360.00$576.00$1,260.00

2’-Fluoro-2’-deoxycytidine (N-Ac)
3’-CEP, M.W. 789.83
2’-Fluoro-2’-deoxyguanosine (N-iBu)
3’-CEP, M.W. 857.91
2’-Fluoro-2’-deoxyguanosine (N-DMF)
3’-CEP, M.W. 842.89
2’-Fluoro-2’-deoxyuridine
3’-CEP, M.W. 748.78$105.00$190.00$305.00$490.00$980.00$115.00$205.00$320.00$526.00$1,055.00$125.00$225.00$360.00$576.00$1,260.00$105.00$190.00$305.00$490.00$980.00

B

O
O

F
lcaa-CPG
O

Succinyl lcaa Supports & Columns
Catalog #

A
A
C
G
G
U

Product Name

Catalog #

N-Bz
N-DMF
N-Ac
N-iBu
N-DMF
N/A

N-1058N-1067
N-1057
N-1055
N-1069N-1056
Bulk CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

0.2

1.0

0.2

1.0

mg

µmole

µmole

µmole

µmole

$110

$145

$165

$295

$365

$110

$145

$165

$295

$365

$85

$105

$125

$210

$250

$110

$145

$165

$295

$365

$110

$145

$165

$295

$365

$85

$105

$125

$210

$250

Chromophores &Ligands

2’-Fluoro-2’-deoxyadenosine (N-Bz)
3’-lcaa CPG
2’-Fluoro-2’-deoxyadenosine (N-DMF)
3’-lcaa CPG
2’-Fluoro-2’-deoxycytidine (N-Ac)
3’-lcaa CPG
2’-Fluoro-2’-deoxyguanosine (N-iBu)
3’-lcaa CPG
2’-Fluoro-2’-deoxyguanosine (N-DMF)
3’-lcaa CPG
2’-Fluoro-2’-deoxyuridine
3’-lcaa CPG

Protection

RNA Purification

N-1058-05
N-1058-10
N-1067-05
N-1067-10
N-1057-05
N-1057-10
N-1055-05
N-1055-10
N-1069-05
N-1069-10
N-1056-05
N-1056-10

2’-Fluoro-2’-deoxy Nucleosides Supports with baseProtection

Modified RNAOStandard RNA

B
DMTrO

DNA Purification

ANP-9152

159414-99-0

Modified DNA

Catalog #B

Ancillary Reagents

2’-Fluoro-2’-deoxy Amidites with Base Protection

B

2’-Fluoro nucleoside phosphoramidites:

A number of 2’-deoxy-2’-fluoro nucleosides have been found to display significant biological activity as nucleosides and as triphosphates, and are used as versatile probes
for DNA and RNA polymerases (see review article; Viani, F., Stereochemical Challenges and Biomedical Targets; Soloshonola, V.A. Ed. Chapter 13, pp 419-449, John Wiley& Sons Ltd. 1999; Wright G.E., Brown N.C. Ther. Pharmacol. 1990, 47, 447). The incorporation of the deoxyfluoronucleosides into oligonucleotides imparts very interesting
biological properties to fluorinated oligomers (Reif, B., Wittmann, V., Schwalbe, H., Griesinger, C., Jahn-Hofmann, K., Engels, J.W. Helv. Chim. Acta 1997, 80, 1952).

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Antisense78

Oligo Synthesis Products
Phosphoramidites and Phosphoramidites
Supports
for Modified
Synthesis
andSupportsforPhosphoramidites
andRNA
Supports
forModified
ModifiedRNA
RNASynthesis
Synthesis

2’-Fluoro-2’-deoxy Amidites with labile Base Protection
2’-Fluoro-2’-deoxyadenosine (N-PAC)-3’-CEP

2’-Fluoro-2’-deoxyguanosine (N-iPrPAC)-3’-CEP
Catalog#Catalog#
NHPAC
N

N

ANP-9131

N

O

CH3
O

N

Pricing

O

N

NH

N

DMTrO

O
P

ANP-9134

O
N
N

N
H

CH3

DMTrO
O

$60.00 / 100 μmole$130.00 / 250 mg$210.00 / 500 mg$336.00 / 1 g

F
OCE

C48H53FN7O8P
Mol. Wt.: 905.95

O$60.00 / 100 μmole$130.00 / 250 mg$210.00 / 500 mg$336.00 / 1 g

FPNPricing

OCE

C51H59FN7O9P
Mol. Wt.: 964.03

Purity: 98% +Purity: 98% +2’-Fluoro-2’-deoxy Amidites for Reverse Direction Synthesis
2’-Fluoro-2’-deoxycytidine (N-Ac)-5’-CEP

2’-Fluoro-2’-deoxyuridine-5’-CEP

Catalog#Catalog#

ANP-8192

NHAc
N
N
N

NH
O

O
P
OCE

ANP-8194

O

O

DMTrO
F
C41H49FN5O8P
Mol. Wt.: 789.83

N

PricingN$60.00 / 100 μmole$130.00 / 250 mg$210.00 / 500 mg$336.00 / 1 g
CAS No. 159414-99-0
Purity: 98% +

O

O
P
OCE

O

DMTrO
F
C39H46FN4O8P
Mol. Wt.: 748.78

Pricing$60.00 / 100 μmole$130.00 / 250 mg$210.00 / 500 mg$336.00 / 1 g
CAS No. 146954-75-8
Purity: 98% +79

Toll Free: (800) 762-9323
Toll Free:(800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products
Phosphoramidites
Phosphoramidites
and Supports
andforSupports
Modifiedfor
RNA
Modified
Synthesis
RNA Synthesis

2’-Deoxy-2’-Fluoro-5-Methyl Amidites with Base Protection

O

N

Catalog #

B

F
OCE

Protection

5-Me C
5-Me C
5-Me U

Product Name

Catalog#
ANP-9231
ANP-9232
ANP-9233

N-Ac
N-Bz
N/A

500mg

1g

2g

5g

2’-Fluoro-5-methyl-2’-deoxycytidine (N-Ac)-3’-CEP, M.W. 803.86$120.00$215.00$385.00$690.00$1,240.00

ANP-9232

2’-Fluoro-5-methyl-2’-deoxycytidine (N-Bz)-3’-CEP, M.W. 865.92
2’-Fluoro-5-methyl-2’-deoxy
uridine-3’-CEP, M.W. 762.80$120.00$215.00$385.00$690.00$1,240.00$120.00$215.00$385.00$690.00$1,240.00

ANP-9233

2’-Fluoro-2’-deoxyinosine-3’-CEP

N

Catalog#

NH

O
I

ANP-9234

NH
N

N

DMTrO

O
P
N

Pricing

PricingO

F
OCE

Purity: 98% +

O
P
N

F
OCE

C39H45FIN4O8P
Mol. Wt.: 874.6$255.00 / 100 μmole$655.00 / 250 mg$1025.00 / 500 mg

Modified RNA

C40H46FN6O7P
Mol. Wt.: 772.80$255.00 / 100 μmole$655.00 / 250 mg$1025.00 / 500 mg

ANP-9235

O

DMTrO
O

Standard RNA

N

2’-Fluoro-5-Iodo-2’-deoxyuridine-3’-CEP

Catalog#O

DNA Purification

250mg

ANP-9231

Modified DNA

OP

Ancillary Reagents

B
DMTrO

Purity: 98% +RNA Purification
Chromophores &Ligands

80

Email: info@chemgenes.com

Antisense

www.chemgenes.com
Email: info@chemgenes.com
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Oligo Synthesis Products
Phosphoramidites and Supports for Modified RNA Synthesis
2’-O-TBDMS-2,6-Diamino-purine(N2, N6-dipac)-3’-CEP

2’-O-TBDMS-purine-riboside-3’-CEP; Nebularine CEP(2’-O-TBDMS-purine-Riboside-3’-CEP)(2-Amino-2’-O-TBDMS-adenosine-3’-CEP)

Catalog#

NHPAC
N
N

Catalog#

N

N

N
N

ANP-8613

NHPAC

N

ANP-8616

N

DMTrO

DMTrO

O

O

Pricing

O-TBDMSO

Pricing

O-TBDMS

O

P
N

OCE

$325.00 / 100 μmole$625.00 / 250 mg$1125.00 / 500 mg

C62H75N8O11PSi
Mol. Wt.: 1167.37$245.00 / 100 μmole$630.00 / 250 mg$1130.00 / 500 mg

P
N

OCE

C46H61N6O7PSi
Mol. Wt.: 869.07

Purity: 98% +Purity: 98% +2-Amino-2’-O-TBDMS-purine (N-DMF)-riboside-3’-CEP

2-Amino-2’-O-TBDMS-purine (N-iBu)-riboside-3’-CEP(2’-O-TBDMS-2-Amino-purine (N-DMF)-riboside-3’-CEP)(2’-O-TBDMS-2-Amino-purine (N-iBu)-riboside-3’-CEP)

Catalog#
N

N

N

N

Catalog#

ANP-8617

NHiBu

N

O
O

C50H68N7O8PSi
Mol. Wt.: 954.18

PricingOO$ 295.00 / 100 μmole$ 690.00 / 250 μmole$1210.00 / 500 mg

OCE

N

N

DMTrO

Pricing

O-TBDMSP
N

ANP-8619

N
N

N

DMTrO

O-TBDMS$370.00 / 100 μmole$880.00 / 250 mg$1510.00 / 500 mg

P
N

OCE

C49H67N8O7PSi
Mol. Wt.: 939.17

Purity: 98% +Purity: 98% +3’-Succinyl lcaa Supports & Columns
Catalog #N-9040-05
N-9040-10
N-9070-05
N-9070-10
N-9080-05
N-9080-10

Product Name
2-Amino-2’-O-TBDMSAdenosine-3’-lcaa CPG
2-Amino-2’-O-TBDMSpurine-riboside-3’-lcaa CPG
2’-O-TBDMS-Purineriboside-3’-lcaa CPG

Bulk CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$120

$615

$95

$165

$190

$330

$120

$610

$95

$165

$190

$330

$110

$610

$95

$165

$190

$330

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

81

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

(2’-Amino (TFA)-uridine-3’-CEP)(2’-Amino (TFA)-cytidine (N-Bz)-3’-CEP)

Catalog#Catalog#
NHBz

CF3

OCE O

C48H52F3N6O9P
Mol. Wt.: 944.93

O

PricingO$245.00 / 100 μmole$510.00 / 250 mg$840.00 / 500 mg

O

HN

CF3

P
N

OCE O

C41H47F3N5O9P
Mol. Wt.: 841.8

Purity: 98% +Modified DNA

HN

P
N

N
DMTrO

PricingO

ANP-9403

NH

O

N
DMTrO

O

O

ANP-5322

N

Ancillary Reagents

2’-Amino (TFA)-uridine-3’-CEP

2’-Amino (TFA)-cytidine-3’-CEP$245.00 / 100 μmole$575.00 / 250 mg$920.00 / 500 mg

Purity: 98% +DNA Purification

5’-Amino (TFA)-2’-O-TBDMS-cytidine-3’-CEP(5’-Amino (TFA)-2’-O-TBDMS-Cytidine (N-Ac)-3’-CEP)

Catalog#

NHAc

ANP-9405NNO

Standard RNA

CF3CONHOO

Pricing
O-TBDMSPN

Standard DNA

Phosphoramidites and Supports for Modified RNA Synthesis

OCE

C28H46F3N6O7PSi
Mol. Wt.: 694.76$280.00 / 100 μmole$790.00 / 250 mg$1260.00 / 500 mg

Purity: 98% +Catalog #Product Name

Pore Size

Bulk CPG

pack of 4 cols.

Modified RNA

Succinyl lcaa Supports & Columns

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

2’-Amino (TFA)-uridine3’-lcaa CPG

500Å
1000Å

$110

$610

$90

$155

$180
$310
			

N-9015-05

2’-Amino (TFA)-cytidine-

500Å

$110

$610

$90

$155

$180

$310

		

RNA Purification

N-9010-05
N-9010-10

Chromophores &Ligands

www.chemgenes.com
Email: info@chemgenes.com

Antisense82

Phosphoramidites and Supports for Modified RNA Synthesis
7-Deaza-2’-O-TBDMS-adenosine(N-Bz)-3’-CEP;
Tubercidin CEP; (7-Deaza-2’-O-TBDMS-adenosine (N-Bz)-3’-CEP)(7-Deaza-2’-O-TBDMS-guanosine (N-iBu)-3’-CEP)

Catalog#Catalog#

NHBz

ANP-7101NN

7-Deaza-2’-O-TBDMS-guanosine (N-iBu)-3’-CEP

ANP-7301

O

N

NH

DMTrO
N

O
O

Pricing$440.00 / 100 μmole$1045.00 / 250 mg$1880.00 / 500 mg

O

O-TBDMS$440.00 / 100 μmole$1045.00 / 250 mg$1880.00 / 500 mg

P
N

Pricing

NHiBu

N

DMTrO

OCE

C54H67N6O8PSi
Mol. Wt.: 987.20

O-TBDMS

O
P
N

OCE

C51H69N6O9PSi
Mol. Wt.: 969.19

Purity: 98% +Purity: 98% +CAS No. 144994-95-6

7-Deaza-2’-O-TBDMS-guanosine (N-iBu)-5’-CEP

7-Deaza-2’-O-TBDMS-guanosine (N-Ac)-3’-CEP(3’-DMT 7-Deaza-2’-O-TBDMS-guanosine (N-iBu)-5’-CEP)(7-Deaza-2’-O-TBDMS-guanosine (N-Ac)-3’-CEP)

Catalog#O

ANP-7102

NH
N
N

O
P
OCE
DMTrO

N

NH
N

N

NHAc

ANP-7302

DMTrO

NHiBu

O

PricingO

Catalog#OO$480.00 / 100 μmole$1150.00 / 250 mg$2060.00 / 500 mg

O-TBDMS

C51H69N6O9PSi
Mol. Wt.: 969.19

Pricing

O-TBDMSPN

OCE

C52H69N5O9PSi
Mol. Wt.: 941.12$440.00 / 100 μmole$1045.00 / 250 mg$1880.00 / 500 mg

Purity: 98% +Purity: 98% +7-Deaza-7-cyano-2’-O-TBDMS-adenosine (N-Bz)-3’-CEP(7-Deaza 7-cyano -2’-O-TBDMS-adenosine (N-Bz)-3’-CEP)

Catalog#
CN

NHBz

ANP-7306

N
N

N

Pricing

DMTrO
O
O
P
N

O-TBDMS
OCE

C55H66N7O8PSi
Mol. Wt.: 1012.21

3’-Succinyl lcaa Supports & Columns
Catalog #Product Name

$480.00 / 100 μmole$1150.00 / 250 mg$2060.00 / 500 mg

Purity: 98% +Bulk CPG

Pore Size

N-9897-05

7-Deaza-2’-O-TBDMS-adenosine (N-Bz)

500Å

N-9897-10

3’-lcaa CPG (Tubercidine CPG)

1000Å

N-9895-05

7-Deaza-2’-O-TBDMS-

500Å

N-9895-10

guanosine (N-iBu)-3’-lcaa CPG

1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$95

$685

$110

$190

$220

$380

$95

$685

$110

$190

$220

$380

83

Toll Free: (800) 762-9323
Toll Free: (800) 762-9323

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramidites
and Supports
for Modified
RNA Synthesis
Phosphoramidites
and Supports
for Modified
RNA Synthesis

Ancillary Reagents

5-Iodo-2’-O-TBDMS-uridine-3’-CEP

5-Iodo-2’-O-TBDMS-cytidine (N-Bz)-3’-CEP(5-Iodo-2’-O-TBDMS-cytidine (N-Bz)-3’-CEP)

Catalog#Catalog#

NHBz

ANP-7212

N

I

NH

O

N

O

N

DMTrO

OCE

C52H65IN5O9PSi
Mol. Wt.: 1090.06

PricingOO$185.00 / 100 μmole$400.00 / 250 mg$720.00 / 500 mg

O-TBDMSPN

OCE

C45H60IN4O9PSi
Mol. Wt.: 986.94

5-Bromo-2’-O-TBDMS-uridine-3’-CEP(5-Bromo-2’-O-TBDMS-uridine-3’-CEP)

Catalog#Catalog#O
BrO

ANP-7411

NH

ANP-5648

NStandard RNANNDNA Purification

5-Bromo-2’-O-TBDMS-cytidine (N-Bz)-3’-CEP(5-Bromo-2’-O-TBDMS-cytidine (N-Bz)-3’-CEP)

NHBz$185.00 / 100 μmole$400.00 / 250 mg$720.00 / 500 mg

Purity: 98% +Purity: 98% +Br

Modified DNA

O-TBDMS

P
N

Pricing

DMTrO

O
O

ANP-7412

O

I

O

DMTrO

DMTrO

O

O
O
P
N

Standard DNA

Oligo Synthesis Products

O-TBDMSOCE

C52H65BrN5O9PSi
Mol. Wt.: 1043.

PricingO$180.00 / 100 μmole$415.00 / 250 mg$750.00 / 500 mg

Pricing
O-TBDMSPN

OCE

C45H60BrN4O9PSi
Mol. Wt.: 939.94$180.00 / 100 μmole$415.00 / 250 mg$750.00 / 500 mg

Modified RNA

Purity: 98% +Purity: 98% +5-Fluoro-2’-O-TBDMS-uridine-3’-CEP(5-Fluoro-2’-O-TBDMS-uridine-3’-CEP)

Catalog#O

ANP-6154NHN

RNA Purification

F

O

DMTrO

PricingO
O

O-TBDMSPN

OCE

C45H60FN4O9PSi
Mol. Wt.: 879.04$255.00 / 100 μmole$650.00 / 250 mg$1180.00 / 500 mg

Chromophores &Ligands

Purity: 98% +www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Antisense84

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forModified
ModifiedRNA
RNASynthesis
Synthesis
8-Bromo-2’-O-TBDMS-adenosine (N-DBF)-3’-CEP

8-Bromo-2’-O-TBDMS-adenosine (N-DMF)-3’-CEP

Catalog#Catalog#

ANP-7111
N

N

N

N

PricingN

N

NO

O-TBDMS

O
P
N

N$120.00 / 100 μmole$250.00 / 250 mg$450.00 / 500 mg

N

OCE

N

DMTrO

$110.00 / 100 μmole$240.00 / 250 mg$425.00 / 500 mg

O
O

O-TBDMS

P
N

Purity: 99% +C55H78BrN8O7PSi
Mol. Wt.: 1102.22

Pricing

N

Br

Br
DMTrO

ANP-7112N

OCE

C49H66BrN8O7PSi
Mol. Wt.: 1018.06

Purity: 99% +CAS No. 197712-21-3

8-Bromo-2’-O-TBDMS-guanosine (N-DMF)-3’-CEP
Catalog#
ANP-7113

O
N

NH

Br
N

N

N

N

Pricing

DMTrO
O$120.00 / 100 μmole$250.00 / 250 mg$450.00 / 500 mg

O-TBDMS

O
P
N

OCE

C49H66BrN8O8PSi
Mol. Wt.: 1034.06

Purity: 99% +3’-Succinyl lcaa Supports Columns
Catalog #Product Name

Bulk CPG

Pore SizeN-9809-05

5-Iodo-2’-O-TBDMS-uridine-500Å

N-9809-10

3’-lcaa CPG

1000Å

N-9818-05

5-Bromo-2’-O-TBDMS-uridine-500Å

N-9818-10

3’-lcaa CPG

1000Å

N-9844-05

5-Bromo-2’-O-TBDMS-500Å

N-9844-10

cytidine (N-Bz)-3’-lcaa CPG

1000Å

N-9812-05

8-Bromo-2’-O-TBDMS-adenosine

500Å

N-9812-10(N-DBF)-3’-lcaa CPG

1000Å

N-9832-05

5-Fluoro-2’-O-TBDMS-

500Å

N-9832-10

uridine-3’-lcaa CPG

1000Å

N-9893-05

5-Iodo-2’-O-TBDMS-

500Å

N-9893-10

cytidine (N-Bz)-3’-lcaa CPG

1000Å

8-Oxo-2’-O-TBDMS-guanosine-3’-CEP(8-Oxo-riboguanosine (N-DMF)-3’-CEP

pack of 4 cols.

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$125

$550

$105

$120

$210

$240

$125

$550

$105

$120

$210

$240

$140

$580

$115

$130

$230

$260

$150

$800

$130

$175

$260

$350

$125

$580

$105

$120

$210

$240

$150

$800

$130

$175

$260

$350

8-Oxo-7-allyl-7,8-dihydro-2’-O-TBDMS-Guanosine-3’-CEP(8-Oxo-7-allyl-7,8-dihydro-riboguanosine (N-iBu)-3’-CEP

Catalog#
H
N

N

N

N

DMTrO

N

PricingO
O-TBDMS
OCE

C49H67N8O9PSi
Mol. Wt.: 971.16

ANP-9422
NH

O

N
N

N

O

NH

O

O
P

Catalog#

ANP-9420

O

pack of 10 cols.

100$285.00 / 100 μmole$675.00 / 250 mg$1325.00 / 500 mg

Purity: 99% +

N

NHiBu

PricingDMTrO
OO

O-TBDMSPN

OCE

C53H72N7O10PSi
Mol. Wt.: 1026.24$325.00 / 100 μmole$768.00 / 250 mg$1520.00 / 500 mg

Purity: 99% +85Toll Free: (800) 762-9323
Toll Free:33(800)762-9323
Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forModified
ModifiedRNA
RNASynthesis
Synthesis2’-O-TBDMS-isoguanosine (N-DBF)-3’-CEP(Isocytidine (N-DBF)-3’-CEP)(Isoguanosine (N-DBF)-3’-CEP)

Catalog#O
N
NN

Catalog#N

ANP-7715

N

N

N

O

Pricing

OCE

DMTrO

O

$370.00 / 100 μmole$790.00 / 250 mg$1420.00 / 500 mg

OCE

C55H75N8O10PSi
Mol. Wt.: 1067.29

Pore Size500Å

N-9712-10 Cytidine (N-DBF)-3’-lcaa CPG

1000Å

N-9827-05 Iso-2’-O-TBDMS-

500Å

N-9827-10 guanosine (N-DBF)-3’-lcaa CPG

1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$155

$810

$120

$145

$240

$290

$155

$810

$120

$150

$240

$300		

Standard RNA

N-9712-05 Iso-2’-O-TBDMS-

Bulk CPG

Purity: 98% +DNA Purification

iso-C & iso-G 3’-Succinyl lcaa Supports & Columns
Product Name

Pricing

O-TBDMS

P
N

Purity: 98% +Catalog #O

O$370.00 / 100 μmole$790.00 / 250 mg$1420.00 / 500 mg

C54H79N6O8PSi
Mol. Wt.: 999.30

N
H

Modified DNA

N

N
O-TBDMS

ANP-5988
N

DMTrO

O
P

Ancillary Reagents

2’-O-TBDMS-isocytidine (N-DBF)-3’-CEP

Standard DNA

Oligo Synthesis Products

Iso-Cytidine and Iso-Guanosine Phosphoramidite
Modified RNA

Iso-Cytidine and Iso-Guanosine are variants of natural Cytidine and Guanosine RNA bases. One of the key advantages of these monomers is their capability of binding
with each other with three hydrogen bonds as shown in the figure below. Additionally these monomers do not recognize naturally occurring Cytidine and Guanosine
bases. Thus they are used for specific sequence based genetic engineering1,2.
1. Switzer, C. Y.; Moroney, S. E.; Benner, S. A. Biochemistry 1993, 32, 10489-10496 & references cited in this article.
2. Chen, X.; Kierzek, R.; Turner, D. H. J. Am. Chem. Soc. 2001, 123, 1267-1774.

H
O

H N

N

RNA Purification

N
H N
N
N

N
N H
H

O

Chromophores &Ligands

Iso-C
Figure: Representing Iso-C and Iso-G base pairingwww.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Antisense86

2’,3’-O-Diacetyl-Guanosine (N-iBu)-5’-CEP

2’,3’-O-Diacetyl-Uridine-5’-CEP

Catalog#Catalog#

O
NH
N

O

N
N

N

O
P
OCE

N

O

PricingOAc OAc
C22H33N4O9P
Mol. Wt.: 528.49

ANP-6156

O

ANP-6155
O
P
OCE

NH
N

NHiBu

$90.00 / 100 μmole$316.00 / 250 mg$570.00 / 500 mg

OAc OAc$80.00 / 100 μmole$320.00 / 250 mg$575.00 / 500 mg

PricingO

C27H42N7O8P
Mol. Wt.: 623.64

Purity: 98% +Purity: 98% +5,6-Dihydro-2’-O-TBDMS-Uridine-3’-CEP
Catalog#O
NH
N

ANP-6066

O

DMTrO

PricingO
O
P
N$220.00 / 100 μmole$565.00 / 250 mg$1015.00 / 500 mg

O-TBDMSOCE

C45H61N4O9PSi
Mol. Wt.: 861.0

Purity: 98% +Terminal Diol Generating Phosphoramidites

2’,3’-O-Diacetyl-5’-phosphoramidites are available from ChemGenes for the introduction of 2’,3’-ribose units at the 5’-end of oligonucleotides. Following ammonia
deprotection, the 2’,3’-diacetate generates a free ribose 2’,3’-diol moiety in the oligonucleotide.
Periodate cleavage of these diols generates dialdehydes (Krynetskaya, N. F.; Zayakina, G. V.; Oretskaya, T. S.; Volkov, E. M.; Shabarova, Z. A. Nucleosides Nucleotides
Nucleicacids 1986, 5, 33). These dialdehydes have been stabilized by amines, especially by terminal amino groups of lysine residue of proteins or polypeptides (Khym,
J. X. Biochemistry 1963, 2, 344). Such oligonucleotide-protein conjugates have been utilized in immuno-assay and diagnostic applications.

Dihydrouridine Phosphoramidite

Dihydrouridine, along with a large number of other modified nucleosides are present abundantly in tRNA, mRNA, shRNA, rRNA and other RNAs1. The catabolic degradation of uridine or the uracil moiety leads to dihydrouridine and enzyme dihydropyrimidine dehydrogenase is involved2. The oligonucleotides containing this baseseem to be crucial in understanding the regulation of enzymes involved in the pathway.
1. Limback, P. A.; Crain, P. F.; McCloskey, J. A. Nucl. Acids Res. 1994, 22, 2183-2196.
2. Gojkovic, Z.; Rislund, L.; Andersen, B.; Sandrini, M. P. B.; Cook, P. F.; Schnackerz, K. D.; Piskur, J. Nucl. Acids Res. 2003, 31, 1683-1692.

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

87

Toll Free: (800) 762-9323
Toll Free:33(800)762-9323
Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forModified
ModifiedRNA
RNASynthesis
Synthesis

Phosphoramiditesand
andSupports
Supportsfor
forModified
ModifiedRNA
RNASynthesis
Synthesis
Phosphoramidites

Ancillary Reagents

ß-L-RNA Phosphoramidites
B

ODMTr
O
O
P

TBDMS-ON

Catalog#

Protection

Catalog#

A
C
G
T
U
C

N-Bz
N-Bz
N-iBu
N/A
N/A
N-Ac

ANP-4841
ANP-4842
ANP-4843
ANP-4844
ANP-4845
ANP-4846

Product name1g$200.00$360.00$640.00$1,152.00$2,592.00

ANP-4842

ß-L-2’-O-TBDMS-Cytidine (N-Bz)3’-CEP, M.W. 964.17
ß-L-2’-O-TBDMS-Guanosine (N-iBu)3’-CEP, M.W. 970.18
ß-L-2’-O-TBDMS-riboThymidine3’-CEP, M.W. 875.07
ß-L-2’-O-TBDMS-Uridine
3’-CEP, M.W. 861.05
ß-L-2’-O-TBDMS-Cytidine (N-Ac)
3’-CEP, M.W. 902.10$200.00$360.00$640.00$1,152.00$2,592.00$200.00$360.00$640.00$1,152.00$2,592.00$200.00$360.00$640.00$1,152.00$2,592.00$200.00$360.00$640.00$1,152.00$2,592.00$200.00$360.00$640.00$1,152.00$2,592.00

ANP-4844
ANP-4845
ANP-4846

5g

ß-L-RNA lcaa Supports

B
ODMTr
O
O
lcaa-CPG
O
O

Protection

Catalog #

A
C
G
U
T
C

N-Bz
N-Bz
N-iBu
N/A
N/A
N-Ac

N-4691
N-4692N-4693N-4694N-4695
N-4696
Bulk CPG

Catalog #

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

500

1

0.2

1.0

0.2

1.0

mg

mg

g

µmole

µmole

µmole

µmole

$110

$125

$220

$250

$135

$425 $850
		$425 $850

$110

$125

$220

$250

$135

$425

$850

$110

$125

$220

$250

$135

$425

$850

$110

$125

$220

$250

$135

$425

$850

$110

$125

$220

$250

$135

$425

$850

$110

$125

$220

$250

$135

Chromophores &Ligands

ß-L-2’-O-TBDMSAdenosine (N-Bz) 3’-lcaa CPG
ß-L-2’-O-TBDMSCytidine (N-Bz)-3’-lcaa CPG
ß-L-2’-O-TBDMSGuanosine (N-iBu)-3’-lcaa CPG
ß-L-2’-O-TBDMSUridine -3’-lcaa CPG
ß-L-2’-O-TBDMSRiboThymidine-3’-lcaa CPG
ß-L-2’-O-TBDMSCytidine (N-Ac)-3’-lcaa CPG

Pore Size

RNA Purification

N-4691-05
N-4691-10
N-4692-05
N-4692-10
N-4693-05
N-4693-10
N-4694-05
N-4694-10
N-4695-05
N-4695-10
N-4696-05
N-4696-10

Product Name

Modified RNA

TBDMS-O

B

Standard RNA

500mg

ß-L-2’-O-TBDMS-Adenosine (N-Bz)3’-CEP, M.W. 988.19

DNA Purification

250mg

ANP-4841

ANP-4843

2g

Modified DNA

CE-O

B

Standard DNA

Oligo Synthesis Products*Currently we are offering 2’-O-TBDMS-3’-lcaa CPG Products instead of 3’-O-TBDMS-2’-lcaa CPG

www.chemgenes.com
Email: info@chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com

Antisense88Oligo Synthesis Products
Phosphoramidites and Supports for Modified RNA Synthesis
RNA Ethyl Phosphoramidites with Labile (Mild) Base Protection

B
DMTrO
O
O-TBDMS

O
P
N

O

CH3

Catalog#
ANP-4131
ANP-4132
ANP-4133
ANP-4134

B

Protection

Catalog#

A
C
G
U

N-PAC
N-PAC
N-PAC
N/A

ANP-4131
ANP-4132
ANP-4133
ANP-4134

Product name

250mg

500mg

1g

$180.00$325.00$590.00$1,060.00$2,375.00$180.00$325.00$590.00$1,060.00$2,375.00$180.00$325.00$590.00$1,060.00$2,375.00$180.00$325.00$590.00$1,060.00$2,375.00

2’-O-TBDMS-Adenosine (N-PAC)
3’-Ethyl Phosphoramidite, M.W. 993.21
2’-O-TBDMS-Cytidine (N-PAC)
3’-Ethyl Phosphoramidite, M.W. 969.18
2’-O-TBDMS-Guanosine (N-PAC)
3’-Ethyl Phosphoramidite, M.W. 1009.21
2’-O-TBDMS-Uridine
3’-Ethyl Phosphoramidite, M.W. 836.04

2g

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK89

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

5g

RNA Purification RNA Purification
RNA purification is significantly more difficult than DNA purification due to possible chain cleavage and isomerization of the internucleotide phosphate
linkage. Several methodologies for deprotection and purification have been developed.

Small Quantity Purification

A summary of procedures is outlined below. Detailed protocols are available, with the products supplied to customers.

Caution: Only de-ionized RNase, pyrogen, nucleases and bacteria free water and filtered through a membrane with a filter unit capable of high molecularweight cut off should be used (preferably Millipore unit) for manipulations involving subsequent steps. Similarly all buffers to be used require this qualityof water.

DNA Purification

Example of Oligonucleotide Purification using 2’-O-TBDMS-N-(Abz; Gibu; CAc & U) protected RNA monomers:

Modified DNA

The first step following the synthesis of oligonucleotides involves a base treatment to remove the N-protecting and cyanoethyl groups. For base deprotection, both 28% aqueous ammonia containing ethanol (1:3) or anhydrous saturated ethanolic ammonia solutions have been used. The latter was found tobe superior in preventing the loss of any silyl groups (Scaringe, S. A.; Francklyn, C.; Usman, N. Nucl. Acids Res. 1990, 18, 5433). It has been reported
that a certain amount of silyl groups will be lost when using the former ammonia solution (Stawinski, J.; Stromberg, R.; Thelin, M.; Westman, E. Nucl.
Acids Res. 1988, 16, 9285).
The second step in the deprotection process involves removal of silyl protecting groups (TBDMS).This has been accomplished by 1.0 M solution of tetrabutylammoniumfluoride (TBAF) in THF. The reaction involves 50 equivalents of TBAF per TBDMS group during 24 hours. Even though initially deemed
adequate, this method is slow and still leaves some TBDMS groups on the oligonucleotide. Much better results have been obtained with triethylaminetris-hydrofluoride (TEA.3HF). In the synthesis of 76-mer tRNA the reaction with neat TEA.3HF for 14 hours resulted in complete removal of all TBDMS
groups (Gasparutto, D.; Livache, T.; Bazin, H.; Duplaa, A.-M.; Guy M.; Khorlin, A.; Molko, D.; Roget, A.; Toule, R. Nucl. Acids Res. 1992, 20,5159). The
faster rate of silyl removal with TEA.3HF has been demonstrated by others (Sproat, B.; Colonna, F.; Mullah, B.; Tsou, D.; Andrus, A.; Hampel, A.; Vinayak,
R. Nucleosides & Nucleotides, 1995, 14, 255).

Ancillary Reagents

Purification of synthetic RNA

Standard DNA

Oligo Synthesis Products

Deprotection Procedures:
Methyl Amine Deprotection: Cleavage from the solid support and deprotection of bases with methyl amine (MA; 40% methylamine in water; 1.0ml),

AMA Deprotection: Support cleavage and base deprotection with ammonium hydroxide : methylamine (AMA; 1:1; 1.5 ml), at different time intervals
depending on sequence length results in based deprotected oligo. Subsequently the fully deprotected oligonucleotide is quenched with 50mM TEAB
followed by cooling at -70 C and precipitation with n-butanol. The precipitated oligo dissolved in 0.1 M TEAA buffer (pH; 7.5) and filtered through 0.45
micron filter and HPLC purification is carried out. The oligo is them lyophilized as triethylamine salt to dry powder.

Modified RNA

Puripak Cartridge (ChemGenes Cat # CSS-5232) Purification: The oligo (from 1.0 uM synthesis) dissolved in 0.1 M TEAB (pH; 7.5), charged on toappropriate size cartridge, eluted by applying a gentle pressure successively with 0.1M, 0.5 M and 1.0 M buffer, collecting 3-4 fractions in each buffer;each fraction being 5 ml. Small volume from the fractions to be dried 3 times with 50:50 mixture of ethanol:water (v/v) on rotary evaporator to remove
buffer salt and analyzed by UV, CE to determine purest fractions. The desired fractions then coevaporation with 50:50 (v/v) ethanol:water. Generally RNA
is present in 0.5 M buffer fraction (shorter length oligos) or in 1.0 M buffer (longer sequences such as 20-mer and above). The thin film of RNA is taken
in 0.1 M TEAA and precipitated with 1.0 M solution of sodium perchlorate in acetone. The precipated oligonucleotide is centrifuged.

Standard RNA

followed by Triethylamine.3HF deprotection of silyl protecting group and subsequent precipitation with n-butanol, cooling at -70 C, followed by centrifugation at 8000 RPM, removal of supernatant is carried out. The solid later dissolved in 0.1M TEAA buffer (pH; 7.5), filtered through 0.45 micron filter and
HPLC purification is carried out.

HPLC Purification: After deprotection and precipitation of crude oligo or oligo obtained after cartridge purification (depending on purity) is subsequently
purified by HPLC. Brief conditions of purification of synthetic RNA’s are as follows:

Mobile Phase: Eluants; 2 mM Tris.HCl ( pH 7.4), 10 mm NaClO4, 6 M urea; & 2 mM Tris. HCl (pH 7.4), 0.55 M NaClO4, 6 M urea; (Purification of Long
chain RNA’s; Pitch, S. et.al., Helv. Chim. Acta, 2001, 84, 3773).

Source 15TM Q** resin columns (Ion- Exchange) Purification: Manufacturer-GE Eluants: 0.5 M Tris:Acetonitrile: water (10:10:80, v/v/v) (Buffer A)& 1.5 M NaCl in Buffer A ( Buffer B). **Source Q is a Trade mark of GE Health Care.
Mono Q HR 10/10 column (GE Health Care): with NaClO4 gradient in Tris buffer (pH 6.8); Eluants: 0.1 M KH2PO4, pH 6.4, 0.05 M NaCl & Eluant

Chromophores &Ligands

B: 0.1 M KH2PO4, pH 6.4, 0.9 M NaCl as well as Eluants: 0.01 M NaClO4, 20 mM Tris HCl, pH 6.8 & 0.6 M NaClO4, 20 mM Tris-HCl, pH , 6.8, containing 10% acetonitrile (Mikhailov, S. N.; Rozensski, J.; Efimtseva, E. V.; Busson, R.; Aerschot, A. V.; Herdewijn, P. Nucl. Acids Res. 2002, 30,1124-1131);
RNA’s containing N-1 methyl adenosine base are separated well.
Desalting: Fractions obtained after HPLC are desalted by; (a) loading on C18 Sep Pak cartridge (Waters/Millipore), (Micura et. al. Nucl. Acids Res.
2000), (b) ChemGenes Cartridges (CSS-5232), (c) NAP25 columns. After desalting the desired fractions are converted into sodium salt with sodium
perchlorate.

RNA Purification

Anion–exchange -DNAPac PA-100 ( 4X250 nm Dionex Column) .

90

Email: info@chemgenes.com

www.chemgenes.com
Email: info@chemgenes.com

Antisense

www.chemgenes.com

Oligo Synthesis Products
RNA Purification
RNA Purification Kit(for Synthetic RNA via 2’-O-TBDMS Protection)

Besides offering highest purity RNA monomers, we also offer RNA deprotection & purification kits. With ChemGenes purification kits and products
you can now synthesize and obtain a high quality of pure synthetic RNA. ChemGenes RNA purification kits include all the solutions and buffers
required to obtain a high quality of synthetic RNA.

Catalog #CSS-5232-02
CSS-5232-10

Quantity
1 kit
1 kit

Prices$140.00 / 0.2 μm$192.00 / 1.0 μm

The RNA Purification kit consist of the Following:• CSS-3268 (10 ml)• CSS-5272 (pack of 10)• CSS-6634 (50 ml)• CSS-5232 (25 ml)

Anhydrous Ammonia in Ethanol Solution(20% ammonia by wieght in absolute ethanol )NH3. F.W.: 17
C2H6O. F.W.: 46.07

Catalog #CSS-3268

Quantity
10 ml

Prices$35.00

Ideal for selective deprotection of the base protecting groups and the cyanoethyl groups and preventing
chain cleavage isomerization of 3’-5’ phosphordiester bond in the final RNA.
(ref: Taifeng Wu, Kelvin K. Ogilive, Richard T. Pon, Nucl. Acids Res., 1989, 17, 3501.)

RNA Purification Cartridges
Catalog #CSS-5272-02
CSS-5272-10

Quantity
pack of 10
pack of 10

Prices$60.00 / 0.2 μm$125.00 / 1.0 μm

The RNA purification cartridges are designed for the purification of short to medium length RNA oligonucleotides. The seperation of different length oligos is based on charges on the ion-exchenge media inthe cartridges. They achieve excellent purification of the oligonucleotide.

Tetra Butyl Ammonium Fluoride (TBAF)(1M Solution in Tetrahydrofuran)
C16H38FN
F.W.: 261.47

Catalog #CSS-4356

Quantity
25 ml

Prices$30.00Used to remove silyl-protecting groups after the oligonucleotide synthesis.
Moisture Content adjusted for optimum silyl group removal.

Fluoride Ion Removal Solution
Catalog #CSS-6634

Quantity
50 ml

Prices$50.00This is used to remove all the fluoride and organic bye products after tetra butyl ammonium fluoride stepin RNA deprotection.

91

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Amidites amidites
and Supports
for 2’-O-Alkyl/Antisense
Oligonucleotides
2’-O-Alkyl Modified& Support/ Antisense Oligonucleotides

Ancillary Reagents

Antisense (i.e. sequences complimentary to the “sense” strand, or usually messenger RNA) and otherwise interfering (e.g. “decoy”) oligonucleotides,
oligoribonucleotides (ONs), and modified ONs have gained overhelming popularity for interference in various steps leading from DNA transcription tomRNA translation. Such regulatory interference has been harnessed for therapeutic effects against many diseases and viral infections. Production ofviral proteins are inhibited by oligonucleotides that are complimentary to portions of mRNA for that protein (i.e.antisense). Other regulatory mechanismsof viruses, such as HIV, have been targeted for interference with the use of complimentary (i.e. antisense), or decoy (i.e. sense) ONs. Oligonucleotides
for therapy have several advantages. These include the extremely high specificity and the ease of design based on Watson-Crick base pairing. The highassociation constants imply a strong duplex formation and thus effectiveness at low concentrations.

Standard DNA

Oligo Synthesis Products

They Hybridize with Natural Targets leading to Diagnostic & Therapeutic Applications

		

2’-OMe Modified Synthetic ONs

			Lipophilic, Ampiphilic			Degradation by nucleases
			Less Specificity
			Lower Tm

DNA Purification

Poor Uptake•Molecule too big• Highly charged
Nuclease ResistantGreater Specificty, Reacts Rapidly
Higher Tm

Modified DNA

Unmodified ONS

Combination of phosphorothioate phosphodiester regenerates RNaseH activity.
											Synthetic Antisense oligo (2’-O-me Modified) are designed to;Permeate through cell membrame									
		Bind to target RNA											Inactivate the target RNA

Antisense

1. Inoune, H.; Hayese, Y.; Imura, A.; Iwai, S.; Miura, K.; Ohtsuka, E. Nucl. Acids Res. 1987, 15, 6131-6148.
2. Shibahara, S.; Mukai, S.; Nishihara, T.; Inoune, H.; Ohtsuka, E.; Morisawa, H. Nucl. Acids Res. 1987, 15, 4403-4415.
3. Dunlap, B. F.; Friderici, K. H.; Rottman, F. Biochemistry, 1971, 10, 2581-2587.
4. Shibahara, S.; Mukai, S.; Morisawa, H.; Nakashima, H.; Kobayashi, S.; Yamamoto, N. Nucl. Acids Res. 1989, 17, 239-252.
5. Lamond, A. I.; Sproat, B. S.; Ryder, U.; Hamm, J. Cell 1989, 58, 383-390.
6. Barbino, S.; Sproat, B. S.; Ryder, U.; Blencowe, B. J.; Lamond, A. I. Cell, 1989, 59, 531-539.
7. Hall, R. H. “The Modified Nucleosides in Nucleic Acids”, Columbia University Press, 1971, New York, NY.
8. Cotton, M.; Oberhauser, B.; Schaffner, G.; Wagner, E.; Birnsteil, M. L. Nucl. Acids Res. 1991, 19, 2629-2635.
9. Agarwal, S.; Tang, J. Y., Antisense Res. and Devel. 1992, 4, 261.
10. Michael, J. G. XII International Roundtable, Nucleosides, Nucleotides & Their Biological Applications, 1996, La Jolla, CA, Sep 15-19, Abstract 0850.

RNA Purification

References

Modified RNA• 2’-O-Methyl oligonucleotides have been used as chimeric oligomers with DNA-oligomers for site directed cleavage of RNA with RNaseH1,2.
• 2’-O-Methyl oligonucleotides are more stable against several nucleases as compared to the deoxy and ribo type of oligomers. Therefore, the 2’-O-Methyl
oligonucleotides are less susceptible to several nucleases3.
• The use of 2’-O-Methyl and mixed phosphorothioates results in an inhibitory effect against HIV induced cytopathic effects and expressions of the virus
specific antigens in cultures MT-4 cells. The anti-viral activity seems to be strongly concerned with the resistance to one or the other kind of deoxynucleases4.
• 2’-O-Methyl oligoribonucleotides form stable hetero-duplexes with the complimentary RNA. The hybrid formed has a high, or a higher Tm than the corresponding DNA sequence1.
• 2’-O-Methyl ribonucleotides have been used as valuable antisense probes for studying pre-mRNA splicing and the structures of splicosomes5,6.
• The 2’-O-Methylethers of common ribonucleosdes have been found as minor components of RNA7,8.
• A number of biotechnology oriented companies in the U.S. are currently involved in the development of DNA-based diagnostic and therapeutic products,
using 2’-O-Methyl oligonucleotide sequences9, such as GEMR132 being developed for HCMV treatment10.
• Antisense ONS have inhibited several gene functions in mammalian cell lines such as myc, bcl-2 (relevant to lymphomas), and erb-B2 (relevant to breast
cancer).

Standard RNA

Biological Properties of 2’-O-Methyl RNA Molecules

ChemGenes offers a number of special modified phosphoramidites: new modifications of Antisense producing oligos.

www.chemgenes.com
Email: info@chemgenes.com www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

92

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl RNA Amidites With Standard Base Protection
B
RO
O
O
P
N

O-CH3
OCE

R

B

DMTr
DMTr
DMTr
DMTr
DMTr
MMTr
MMTr

A
C
G
U
C
A
G

Protection
N-Bz		
N-Bz		
N-iBu		N/A		N-Ac		
N-Bz		
N-iBu		

Catalog#

CAS No.

ANP-5751
ANP-5752
ANP-5753
ANP-5754
ANP-6756
ANP-5756
ANP-5757

110782-31-5
110764-78-8
150780-67-9
110764-79-9
199593-09-4

Catalog#

Product name

250mg

500mg

1g

2g

5g

10g

ANP-5751

2’-O-Methyl-adenosine (N-Bz)-$45.00$81.00$146.00$263.00$657.00$1,183.00

ANP-5752

2’-O-Methyl-cytidine (N-Bz)-$45.00$81.00$146.00$263.00$657.00$1,183.00$45.00$81.00$146.00$263.00$657.00$1,183.00$45.00$81.00$146.00$263.00$657.00$1,183.00$45.00$81.00$146.00$263.00$657.00$1,183.00$45.00$81.00$146.00$263.00$657.00$1,183.00$45.00$81.00$146.00$263.00$657.00$1,183.00

3’-CEP, M.W. 887.96
3’-CEP, M.W. 863.93
ANP-5753

2’-O-Methyl-guanosine (N-iBu)3’-CEP, M.W. 869.94

ANP-5754

2’-O-Methyl-uridine3’-CEP, M.W. 760.81

ANP-6756

2’-O-Methyl-cytidine (N-Ac)3’-CEP, M.W. 801.86

ANP-5756

5’-O-MMTr-2’-O-Methyl-adenosine (N-Bz)3’-CEP, M.W. 857.93

ANP-5757

5’-O-MMTr-2’-O-Methyl-guanosine (N-iBu)3’-CEP, M.W. 839.92

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

93

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Amidites amidites
and Supports
for 2’-O-Alkyl/Antisense
Oligonucleotides
2’-O-Alkyl Modified& Support/ Antisense Oligonucleotides

Ancillary Reagents

2’-O-Methyl RNA Supports With Standard Base Protection
B
DMTrO
O
O-CH3
lcaa-CPG
O
O

Protection

A
C
G
U
C
G

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N-DMF

		

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 10 cols.

100

250

1

40

0.2

1.0

10

15

40

0.2

1.0

mg

mg

g

nmole

µmole

µmole

µmole

µmole

nmole

µmole

µmole

$38

$80

$285

$50

$60

$75

$150

$225 $100

$120

$150

$38

$80

$285

$50

$60

$75

$150

$225

$100

$120

$150

$38

$80

$285

$50

$60

$75

$150

$225

$100

$120

$150

$38

$80

$285

$50

$60

$75

$150

$225

$100

$120

$150

$38

$80

$285

$50

$60

$75

$150

$225

$100

$120

$150

$38

$80

$285

$50

$60

$75

$150

$225

$100

$120

$150

Modified RNA

2’-O-Methyl-adenosine(N-Bz)-3’-Icaa CPG
2’-O-Methyl-cytidine(N-Bz)-3’-Icaa CPG
2’-O-Methyl-guanosine(N-iBu)-3’-Icaa CPG
2’-O-Methyl-uridine3’-Icaa CPG
2’-O-Methyl-cytidine(N-Ac)-3’-Icaa CPG
2’-O-Methyl-guanosine(N-DMF)-3’-Icaa CPG

eachStandard RNA

N-7910-05
N-7910-10
N-7911-05
N-7911-10
N-7912-05
N-7912-10
N-7904-05
N-7904-10
N-7905-05
N-7905-10
N-7914-05
N-7914-10

Product Namepack of 4 cols.

DNA Purification

Bulk CPG

Catalog #Catalog#		 N-7910
		 N-7911
		 N-7912
		N-7904
		 N-7905
		 N-7914

Modified DNA

O

B

Standard DNA

Oligo Synthesis Products

RNA Purification

Please Indicate Synthesizer when Ordering
ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

ABI

Akta OligopilotAKwww.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

94

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl RNA Amidites With Labile (Mild) Base Protection
B
DMTrO
O
O
P
N

O-CH3
OCE

B

Protection

Catalog#

CAS No.

A
C
G
G
U
G

N-PAC
N-PAC
N-PAC
N-DMF
N/A
N-iPrPAC

ANP-6751
ANP-6752
ANP-6753
ANP-6759
ANP-5754
ANP-5761

128219-82-9
138906-79-3
128219-77-2
110764-79-9

Catalog#

Product name

250mg

500mg

1g

2g

5g

10g

ANP-6751

2’-O-Methyl-adenosine (N-PAC)3’-CEP, M.W. 917.98
2’-O-Methyl-cytidine (N-PAC)3’-CEP, M.W. 893.96
2’-O-Methyl-guanosine (N-PAC)3’-CEP, M.W. 933.98
2’-O-Methyl-guanosine (N-DMF)3’-CEP, M.W. 854.93
2’-O-Methyl-uridine3’-CEP, M.W. 760.81
2’-O-Methyl-guanosine (N-iPrPAC)3’-CEP, M.W. 976.06$56.00$101.00$182.00$328.00$73.00$1,329.00$56.00$101.00$182.00$328.00$738.00$1,329.00$56.00$101.00$182.00$328.00$738.00$1,329.00$56.00$101.00$182.00$328.00$738.00$1,329.00$45.00$81.00$146.00$263.00$657.00$1,183.00$56.00$101.00$182.00$328.00$738.00$1,329.00

ANP-6752
ANP-6753
ANP-6759
ANP-5754
ANP-5761

Solid Supports for 2’-O-Methyl RNA with Labile (Mild) Base
Protection

B
DMTrO
O
O-CH3

O

lcaa-CPG
O

B

Protection

A
C
G

N-PAC
N-PAC
N-PAC

		

Catalog#		 N-P7901
		 N-P7902
		 N-P7903

O
Bulk CPG

Catalog #N-P7901-05
N-P7901-10
N-P7902-05
N-P7902-10
N-P7903-05
N-P7903-10

Product Name
2’-O-Methyl-adenosine(N-PAC)-3’-Icaa CPG
2’-O-Methyl-cytidine(N-PAC)-3’-Icaa CPG
2’-O-Methyl-guanosine(N-PAC)-3’-Icaa CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

0.2

pack of 10 cols.

100

1

40

1.0

40

0.2

mg

g

nmole µmoleµmole		

1.0

nmole

µmole

µmole

$86

$290

$50

$60

$75		

$100

$120

$150

$86

$290

$50

$60

$75		

$100

$120

$150

$86

$290

$50

$60

$75		

$100

$120

$150

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK95

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products
Amiditesand Supports
2’-O-Alkyl/Antisens
Oligonucleotides
2’-O-Alkyl
Modifiedamiditesfor& Support/ AntisenseeOligonucleotides(5-Methyl-cytidine-2’-O-Methyl (N-DMF)-3’-CEP)

2’-O-Methyl-5-methyl-cytidine (N-Bz)-3’-CEP(5-Methyl-cytidine (N-Bz)-2’-O-Methyl-3’-CEP)

Catalog#N

Ancillary Reagents

2’-O-Methyl-5-methyl-cytidine (N-DMF)-3’-CEP

NHBz

Catalog#

H3C
N
N
O

N

OCE

C44H57N6O8P
Mol. Wt.: 828.93

O

OCE

C48H56N5O9P
Mol. Wt.: 877

2’-O-Methyl-5-methyl-cytidine (N-Ac)-3’-CEP

Catalog#O
H3C

Catalog#

NHAc
CH3
N
O

O

ANP-6555

Standard RNA

ANP-5600

NH

Purity: 98% +DNA Purification(2’-O-Methyl-ribothymidine-3’-CEP)$225.00 / 100 μmole$575.00 / 250 mg$2588.00 / 500 mg

OCH3

P
N

Purity: 98% +2’-O-Methyl-5-methyl-uridine-3’-CEP

N

DMTrO

DMTrO

PricingO
O
P
N$140.00 / 100 μmole$400.00 / 250 mg$720.00 / 500 mg

O-CH3
OCE

C41H51N4O9P
Mol. Wt.: 774.84

N

NH

OCH3

P
N

OCE

C43H54N5O9P
Mol. Wt.: 815.8$225.00 / 100 μmole$615.00 / 250 mg$1105.00 / 500 mg

Purity: 98% +2’-O-Methyl-2,6-diamino (N2, N6-diPAC)-purine-riboside-3’CEP
Catalog#Catalog#

ANP-5758

ANP-8519

Pricing

Pricing$135.00 / 100 μmole$385.00 / 250 mg$693.00 / 500 mg$350.00 / 100 μmole$715.00 / 250 mg$1287.00 / 500 mg

Purity: 98% +Purity: 98% +

N

DMTrO
O
O
P

O

RNA Purification

O
N

Pricing

O

O-CH3
OCE

Antisense

C41H49N6O8P
Mol. Wt.: 784.84

CAS No. 128219-85-2

Email: info@chemgenes.com

Chromophores &Ligands

96

www.chemgenes.com

Modified RNA

Purity: 98% +2’-O-Methyl-inosine-3’-CEP

N

ANP-6556

PricingO$260.00 / 100 μmole$900.00 / 250 mg$1220.00 / 500 mg

O-CH3

P

N

O

Modified DNA

Pricing

O

N

N
DMTrO

DMTrO

O

N

ANP-6554

H3C

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl-5-propynyl-cytidine (N-Bz)-3’-CEP(5-Propynyl-2’-O-Methyl-cytidine (N-Bz)-3’-CEP)

2’-O-Methyl-5-propynyl-uridine-3’-CEP

Catalog#

BzHN

ANP-1874

N

Pricing

DMTrO

O$330.00 / 100 μmole$815.00 / 250 mg$1465.00 / 500 mg

O-CH3

P
OCE

C50H56N5O9P
Mol. Wt.: 901.98(Amino Modifier-2’-O-Methyl-cytidine (N-DMF)-C-6-3’-CEP)

N

O

N
N

O

P
N

6N

H

CF3

OCE

C43H51N4O9P
Mol. Wt.: 798.

Purity: 98% +Amino Modifier-2’-O-methyl uridine CEP(Amino Modifier 2’-O-Methyl-uridine C-6-3’-CEP)

Catalog#ON
H$320.00 / 100 μmole$900.00 / 250 mg$1620.00 / 500 mg

O-CH3

O

Purity: 98% +Amino Modifier-2’-O-methyl-cytidine (N-DMF) CEP

Pricing

O

O

N

O

N

DMTrO

ANP-1347

NH

O

N

Catalog#

O

O
HN

ANP-2583

Catalog#

O
N
H

O

N

O
6N

CF3

H

Pricing

DMTrO

DMTrO

PricingO$370.00 / 100 μmole$769.00 / 250 mg$1384.00 / 500 mg

O-CH3

O
P
N

OCE

C48H58F3N8O10P
Mol. Wt.: 994.99

Purity: 98% +2’-O-Methyl-4-triazolyl-5-methyl uridine-3’-CEP(4-Triazolyl-5’-DMTr-2’-O-Methyl-5-methyl uridine-3’-CEP)

Catalog#
N

N
N

ANP-5604

N
N

O

DMTrO
O
O
P
N

OCH3
OCE

C43H52N7O8P
Mol. Wt.:825.3

Pricing$300.00 / 100 μmole$810.00 / 250 mg$1457.00 / 500 mg

Purity: 98% +

O
O
P
N

ANP-2581

N

O-CH3
OCE

C45H52F3N6O11P
Mol. Wt.: 940.90$325.00 / 100 μmole$769.00 / 250 mg$1384.00 / 500 mg

Purity: 98% +2’-O-Methyl-5-propynyl-cytidine (pdC) &2’-O-Methyl-5-propynyl-uridine (pdU)
The substitution of dC and dT in antisense phosphorothioate oligonucleotides with C-5 propynyl analogues pdC and pdU respectively, showed
effective inhibition of gene expression. Both 2’-deoxy and 2’-OMe nucleotides incorporated into oligonucleotides have higher duplex stability compared to natural bases.1
1. Wagner, R. W.; Matteucci, M. D.; Lewis, J. G.; Gutierrez, A. G.; Moulds,
C.; Froeller, B. C. Science, 1993, 260, 1510.

Amino modifier cytidine & amino modifier uridine
Amino modifier cytidine and amino modifier uridine can be used forinternal oligonucleotide labeling with reporter molecules. In that casethe reporter molecule has minimal interference with base pairing duringhybridization process.

97

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl-5-iodo-uridine-3’-CEP

Catalog#Br

Catalog#

ANP-576

O

ANP-5759

NH

O
N

O

I

O

$220.00 / 100 μmole$595.00 / 250 mg$1071.00 / 500 mg

O-CH3

P
N

OCE

C40H48BrN4O9P
Mol. Wt.: 839.7

ON

Pricing

DMTrO$220.00 / 100 μmole$650.00 / 250 mg$1100.00 / 500 mg

O
O-CH3

O
P
N

Purity: 98% +OCE

C40H48IN4O9P
Mol. Wt.: 886.7

2'-O-Methyl-5-Methoxy Uridine-3’-CEP

Modified DNA

ONH

Pricing

DMTrO

Ancillary Reagents

2’-O-Methyl-5-bromo-uridine-3’-CEP

Purity: 98% +3'-O-Methyl-5-Methoxy Uridine-2’-CEP
Catalog#

ANP-3785

ANP-3784

Pricing$380.00 / 100 mg$830.00 / 250 mg$1310.00 / 500 mg

Purity: 98% +Purity: 98% +Standard RNA

Pricing$360.00 / 100 mg$610.00 / 250 mg$1290.00 / 500 mg

DNA Purification

Catalog#

Modified 2’-O-Methyl 3’-Succinyl lcaa Supports & Columns
B

B
DMTrO

O

O-CH3
lcaa-CPGO		Catalog#		 N-1613
		 N-1613Bz
		
N-9013
		
N-9011
		
N-9012
		
N-5601

N-DMF
N-Bz
N/A
N/A
N/A
N/A

Modified RNA

O

Protection

5-Me C
5-Me CI
5-Br U
5-Iodo U
TO
Modified 2’-O-Methyl 3’-Succinyl lcaa Supports & Columns

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

250

Bulk CPG

pack of 4 cols.

pack of 10 cols.

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$230

$900

$125

$200

$250

$400

$230

$900

$125

$200

$250

$400

$230

$900

$125

$200

$250

$400

$230

$900

$125

$200

$250

$400

$230

$900

$125

$200

$250

$400

$190

$750

$100

$175

$200

$350

98

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

2’-O-Methyl-5-methyl-cytidine(N-DMF)-3’-lcaa CPG
2’-O-Methyl-5-methyl-cytidine(N-Bz)-3’-lcaa CPG
2’-O-Methyl-inosine3’-lcaa CPG
2’-O-Methyl-5-bromouridine-3’-lcaa CPG
2’-O-Methyl-5-iodouridine-3’-lcaa CPG
2’-O-Methyl-ribothymidine3’-lcaa CPG

Pore Size

Antisense

N-1613-05
N-1613-10
N-1613Bz-05
N-1613Bz-10
N-9013-05
N-9013-10
N-9011-05
N-9011-10
N-9012-05
N-9012-10
N-5601-05
N-5601-10

Product NameRNA Purification

Catalog #Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl-7-deaza-adenosine-3’-CEP

2’-O-Methyl-7-deaza-guanosine-3’-CEP

Catalog#Catalog#(7-Deaza-2’-O-Methyl-guanosine (N-iBu)-3’-CEP)(7-Deaza-2’-O-Methyl-adenosine (N-Bz)-3’-CEP)

NHBz

ANP-5951

NH

N
N

N

Pricing

N

DMTrO

O-CH3

P
N

OCE

C49H55N6O8P
Mol. Wt.: 886.9

NHiBu

N

DMTrO
O

O
O

ANP-5953

O$264.00 / 50 μmole$476.00 / 100 μmole$1200.00 / 250 mg$2160.00 / 500 mg$279.00 / 50 μmole$495.00 / 100 μmole$1280.00 / 250 mg$2300.00 / 500 mg

O-CH3

O
P
N

OCE

C46H57N6O9P
Mol. Wt.: 868.95

Purity: 98% +Purity: 98% +2’-O-Methyl-7-iodo-7-deaza-adenosine-3’-CEP

2’-O-Methyl-7-iodo-7-deaza-guanosine-3’-CEP(7-Iodo-7-deaza-2’-O-Methyl-adenosine (N-Bz)-3’-CEP)

Catalog#
NHBz

I

Pricing

Catalog#

ANP-9171I

ANP9173

O

N
NH

N

N

O
O-CH3

O
P
N

N

Pricing

DMTrO

OCE

C49H54IN6O8P
Mol. Wt.: 1012.87

N

NHiBu

DMTrO
O

$320.00 / 50 μmole$576.00 / 100 μmole$1290.00 / 250 mg$2320.00 / 500 mg

O-CH3

O
P
N

OCE

C46H56IN6O9P
Mol. Wt.: 994.85

Purity: 98% +2’-O-Methyl-7-deaza-7-propargyl-guanosine-3’-CEP(7-Deaza-7-propargylamino (TFA)-2’-O-Methyl-adenosine (N-Bz)-3’-CEP)(7-Deaza-7-propargylamino (TFA)-2’-O-Methyl-guanosine (N-iBu)-3’-CEP)

Catalog#

O
NHBz

N
H

$320.00 / 50 μmole$576.00 / 100 μmole$1290.00 / 250 mg$2320.00 / 500 mg

Purity: 98% +2’-O-Methyl-7-deaza-7-propargyl-adenosine-3’-CEP

F3C

Pricing

Catalog#O

ANP-9176

F3C

N

N
H

ANP-9178

O
NH

N

N

DMTrO

Pricing

N

O
O

O-CH3

P
N

OCE

C54H57F3N7O9P
Mol. Wt.: 1036.04

N

NHiBu

DMTrO

$380.00 / 50 μmole$684.00 / 100 μmole$1480.00 / 250 mg$2665.00 / 500 mg

O
O

O-CH3

P
N

OCE

C51H59F3N7O10P
Mol. Wt.: 1018.02

Purity: 98% +Pricing$380.00 / 50 μmole$684.00 / 100 μmole$1480.00 / 250 mg$2665.00 / 500 mg

Purity: 98% +Amino modifier cytidine CEP and amino modifier uridine CEP
Amino modifier cytidine and amino modifier uridine can be used for internal oligonucleotide labeling with reporter molecules. In that case thereporter molecule has minimal interference with base pairing during hybridization process.

99

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Amidites
andamidites
Supports
for 2’-O-Alkyl/Antisense
Oligonucleotides
2’-O-Alkyl
Modified& Support/ Antisense Oligonucleotides

O
O
P
O

CH3

2’-O-Methyl RNA Ethyl Phosphoramidite with Standard Base Protection
B

Protection

Catalog #

A
C
G
T
U

N-Bz
N-Bz
N-iBu
N/A
N/A

ANP-7221
ANP-7222
ANP-7223
ANP-7224
ANP-7225

250mg

500mg

1g

2g

5g

2’-O-Methyl-adenosine (N-Bz)-$65.00$117.00$210.00$378.00$851.00

3’-ethyl phosphoramidite, M.W. 862.95
2’-O-Methyl-cytidine (N-Bz)-$65.00$117.00$210.00$378.00$851.00

3’-ethyl phosphoramidite, M.W. 838.90
2’-O-Methyl-guanosine (N-iBu)-$65.00$117.00$210.00$378.00$851.00

3’-ethyl phosphoramidite, M.W. 844.92
2’-O-Methyl-ribothymidine-$65.00$117.00$210.00$378.00$851.00

3’-ethyl phosphoramidite, M.W. 749.83
2’-O-Methyl-uridine-$65.00$117.00$210.00$378.00$851.00

ANP-7222$1,530.00
ANP-7223$1,530.00
ANP-7224$1,530.00
ANP-7225$1,530.00

10gStandard RNA

Product Name

ANP-7221$1,530.00

DNA Purification

Catalog #Modified DNA

N

O-CH3

Ancillary Reagents

B
DMTrO

3’-ethyl phosphoramidite, M.W. 735.80

For the synthesis of DNA/RNA with neutral charge instead of a negatively charged phosphate back bone, P-Ethoxys not only provide neutral
charge but impart lipophilic character to the synthetic DNA. It is a useful product for the development of delivery of DNA molecules into cells.
With the already established usefulness of 2’-O-Methyl RNA, additional backbone modification to the phosphate neutral charge would provide
valuable products in the field of antisense therapeutics.

RNA Purification

The above products are covered under ChemGenes patent title: Oligonucleotide phosphate esters US#6,015,886.

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

Please Indicate Synthesizer when Ordering
ABI 3900

Akta Oligopilot
AK

Email: info@chemgenes.com

Chromophores &Ligands

100

www.chemgenes.com

Modified RNA

Applications:

ABI

Standard DNA

Oligo Synthesis Products

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides

B

2’-O-Methyl RNA Ethyl Phosphoramidite with Labile Base Protection

DMTrO
O
O
P
N

Catalog #ANP-7227
ANP-7228
ANP-7226

O-CH3
O

B

Protection

Catalog #

A
C
G

N-PAC
N-PAC
N-PAC

ANP-7227
ANP-7228
ANP-7226

CH3

Product Name
2’-O-Methyl-adenosine (N-PAC)
3’-Ethyl phosphoramidite, M.W. 892.97
2’-O-Methyl-cytidine (N-PAC)3’-Ethyl phosphoramidite, M.W. 868.95
2’-O-Methyl-guanosine (N-PAC)3’-Ethyl phosphoramidite, M.W. 908.97

250mg

500mg

1g

2g

5g

10g

$78.00$128.00$230.00$415.00$935.00$1,683.00$78.00$128.00$230.00$415.00$935.00$1,683.00$78.00$128.00$230.00$415.00$935.00$1,683.00

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK101

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Amidites
andamidites
Supports& for2’-O-Alkyl/Antisense
Oligonucleotides
2’-O-Alkyl
Modified
Support/ Antisense Oligonucleotides

Ancillary Reagents

3’-O-Methyl Amidites with Standard Base Protection
B
DMTrO
O
CH3-O
CEO

Catalog #NProtection

Catalog#

CAS No.

A
C
G
U
I
C
T

N-Bz
N-Bz
N-iBu
N/A
N/A
N-Ac
N/A

ANP-2901
ANP-2902
ANP-2903
ANP-2904
ANP-2905
ANP-2906
ANP-2907

179479-02-8
179479-03-9

Product Name

ANP-2902
ANP-2903
ANP-2904
ANP-2905
ANP-2906
ANP-2907O
lcaa-CPG
O
O

2g

5g

$530.00$954.00$2,145.00$165.00$294.00$530.00$954.00$2,145.00$165.00$294.00$530.00$954.00$2,145.00$165.00$294.00$530.00$954.00$2,145.00$165.00$294.00$530.00$954.00$2,145.00$165.00$294.00$530.00$954.00$2,145.00$165.00$294.00$530.00$954.00$2,145.00

Product Name

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

Protection

A
C
G
U
I

N-Bz
N-Bz
N-iBu
N/A
N/A

250

Bulk CPG

Catalog #N-8810N-8811
N-8812
N-8813
N-8814

1

0.2

mg

g

$125

pack of 4 cols.

pack of 10 cols.

1.0

0.2

µmole

µmole

µmole

µmole

1.0

$480

$ 95

$120

$190

$240		

$125

$480

$ 95

$120

$190

$240

$125

$480

$ 95

$120

$190

$240

$125

$480

$ 95

$120

$190

$240

$250

$900

$135

$245

$270

$490

Antisense

3’-O-Methyl-adenosine(N-Bz)-2’-lcaa CPG
3’-O-Methyl-cytidine(N-Bz)-2’-lcaa CPG
3’-O-Methyl-guanosine(N-iBu)-2’-lcaa CPG
3’-O-Methyl-uridine2’-lcaa CPG
3’-O-Methyl-inosine2’-lcaa CPG

Pore SizeB

RNA Purification

N-8810-05
N-8810-10
N-8811-05
N-8811-10
N-8812-05
N-8812-10
N-8813-05
N-8813-10
N-8814-05
N-8814-10

1g		

$294.00

Modified RNAOCatalog #500mg

3’-O-Methyl Supports with Standard Base Protection

B
DMTrO

CH3-O

250mg
$165.00

Standard RNA

3’-O-Methyl-adenosine (N-Bz)2’-CEP, M.W. 887.96
3’-O-Methyl-cytidine (N-Bz)2’-CEP, M.W. 863.93
3’-O-Methyl-guanosine (N-iBu)2’-CEP, M.W. 869.94
3’-O-Methyl-uridine2’-CEP, M.W. 760.81
3’-O-Methyl-inosine2’-CEP, M.W. 784.84
3’-O-Methyl-cytidine (N-Ac)2’-CEP, M.W. 801.86
3’-O-Methyl-ribothymidine2’-CEP, M.W. 774.84

DNA Purification

ANP-2901

179479-05-1

Modified DNA

OPBStandard DNA

Oligo Synthesis Products

The above products are covered under ChemGenes patent title: N-protected-2’-O-methyl-and N-protected-3’-Omethyl-ribonucleosides and their phosphoramidite derivatives US#5,525,719.

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands102

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
B

DNA Ethyl Phosphoramidites with Standard Base Protection

DMTrO
O
O
P
N

O

B

Protection

Catalog#

A
C
G
T

N-Bz
N-Bz
N-iBu
N/A

ANP-6541
ANP-6542
ANP-6543
ANP-6544

Catalog #Product Name

ANP-6541

2’-deoxyadenosine (N-Bz)
3’-Ethyl-phosphoramidite M.W. 832.92
2’-deoxycytidine (N-Bz)
3’-Ethyl-phosphoramidite M.W. 808.90
2’-deoxyguanosine (N-iBu)
3’-Ethyl-phosphoramidite M.W. 814.91
Thymidine 3’-Ethyl-phosphoramidite, M.W. 719.80

ANP-6542
ANP-6543
ANP-6544B

250 mg

500mg

1g

2g

5g

$24

$45

$80

$144

$324

$24

$45

$80

$144

$324

$24

$45

$80

$144

$324

$24

$45

$80

$144

$324

DNA Ethyl Phosphoramidites with Labile (mild) Base Protection

DMTrO
O
O
P
N

Catalog #ANP-5541
ANP-5542
ANP-5543
ANP-6544

O

B

Protection

Catalog #

A
C
G
T

N-PAC
N-PAC
N-PAC
N/A

ANP-5541
ANP-5542
ANP-5543
ANP-6544

Product Name2’-deoxyadenosine (N-PAC)
3’-Ethyl-phosphoramidite M.W. 862.95
2’-deoxycytidine (N-PAC)
3’-Ethyl-phosphoramidite M.W. 838.92
2’-deoxyguanosine (N-PAC)
3’-Ethyl-phosphoramidite M.W. 935.05
Thymidine 3’-Ethyl-phosphoramidite, M.W. 719.80

250mg

500mg

1g

2g

5g

$27.00$48.00$90.00$160.00$360.00$27.00$48.00$90.00$160.00$360.00$27.00$48.00$90.00$160.00$360.00$24.00$45.00$80.00$144.00$324.00

Applications:

For the synthesis of DNA/RNA with neutral charge instead of a negatively charged phosphate backbone, ethyl phosphoramidites not only provide neutral charge but
impart lipophilic character to the synthetic DNA. It is a useful product for the development of delivery of DNA molecules into cells. For clean removal of the base protecting
groups using ammonia free deprotection solution, see the page 101.

103

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products2’-O-Alkyl
Modifiedamiditesfor& Support/ Antisense Oligonucleotides
Amiditesand Supports
2’-O-Alkyl/Antisense
Oligonucleotides

Ancillary Reagents

Oxalyl Supports with Labile (mild) Base Protection for DNA
Synthesis

B
DMTrO
O
O
O

Protection

Catalog #

A
C
G
T

N-PAC
N-PAC
N-PAC
N/A

N-5131
N-5132
N-5133
N-5134

Modified DNAO

Blcaa-CPG

Bulk CPG

Catalog #Product Name

3’-Oxalyl-2’-deoxyadenosine (N-PAC)-3’-lcaa CPG
3’-Oxalyl-2’-deoxycytidine (N-PAC)-3’-lcaa CPG
3’-Oxalyl-2’-deoxyguanosine (N-PAC)-3’-lcaa CPG
3’-Oxalyl-thymidine-3’-lcaa CPG

N-5132-05
N-5133-05
N-5134-05

pack of 10 cols.

100

1

40

0.2

1.0

40

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

µmole

µmole

500Å

$18

$144

$32

$39

$58

$64

$78

$116

500Å

$18

$144

$32

$39

$58

$64

$78

$116

500Å

$18

$144

$32

$39

$58

$64

$78

$116

500Å

$18

$144

$32

$39

$58

$64

$78

$116
Standard RNA

Ammonia Free Oligo Deprotection Solution can be used with the following CPGs:

Ammonia Free Oligo Deprotection Solution

RN-1435$35.00 / 25 ml$55.00 / 50 ml$75.00 / 100 ml

RNA Purification

Pricing

Modified RNA

1. PAC-protected nucleoside phosphoramidites must be used for efficient base deprotection using ammonia free oligo deprotection solution.
2. Oxalyl CPGs can be cleaved from the solid support using ammonia free oligo deprotection solution. The standard succinyl CPGs will not getadequately deprotected when using ammonia free oligo deprotection solution. The synthesized oligo attached on the CPG is washed with
diethyl ether, followed by air drying is placed in a vial. Ammonia free oligo deprotection solution is added and the vial is kept seal during thecleavage and deprotection.

Catalog#

DNA Purification

N-5131-05

Pore Sizepack of 4 cols.

For oxalyl RNA supports please refer to page # 59

Please Indicate Synthesizer when Ordering
ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

ABI

Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

104

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
DNA Methyl Phosphonamidites with Standard Base Protection
B
DMTrO
O
O
P
N

CH3

B

Protection

A
C
G
T
U
I

N-Bz
N-iBu
N-iBu
N/A
N/A
N/A

Catalog#

CAS No.

ANP-7551
114079-05-9
ANP-7556
ANP-7553
115131-08-3
ANP-7554
114079-04-8
ANP-7557		
ANP-7558

Catalog #Product Name

250mg

500mg

1g

ANP-7551

2’-Deoxyadenosine (N-Bz)
3’-[(Methyl)-(N,N-diisopropyl)] phosphonamidite M.W. 802.90
2’-Deoxycytidine (N-iBu)
3’-[(Methyl)-(N,N-diisopropyl)] phosphonamidite M.W. 744.86
2’-Deoxyguanosine (N-iBu)
3’-[(Methyl)-(N,N-diisopropyl)] phosphonamidite M.W. 784.88
Thymidine
3’-[(Methyl)-(N,N-diisopropyl)] phosphonamidite M.W. 689.78
2’-Deoxyuridine
3’-[(Methyl)-(N,N-diisopropyl)]phosphonamidite M.W. 675.75
2’-Deoxyinosine
3’-[(Methyl)-(N,N-diisopropyl)]phosphonamidite M.W. 699.78$50.00$90.00$162.00$292.00$655.00$50.00$90.00$162.00$292.00$655.00$50.00$90.00$162.00$292.00$655.00$50.00$90.00$162.00$292.00$655.00$50.00$90.00$162.00$292.00$655.00$50.00$90.00$162.00$292.00$655.00

ANP-7556
ANP-7553
ANP-7554
ANP-7557
ANP-7558

2g

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

105

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

5g

Standard DNA

Oligo Synthesis Products
2'-O-Alkyl
Modified
Amidites& Support/Antisense
Oligonucleotides
2’-O-Alkyl
Modifiedamidites& Support/ Antisense
Oligonucleotides

O
O

O-CH3

P
CH3

ANP-8551
ANP-8552
ANP-8553

ANP-8556

Catalog#

CAS No.

N-Bz
N-iBu
N-iBu
N/A
N-Ac

ANP-8551
ANP-8552
ANP-8553
ANP-8554
ANP-8556

110782-30-4

Product Name
2’-O-Methyl-adenosine (N-Bz)
3’-[(Methyl)-(N,N-diisopropyl)]-phosphonamidite M.W. 832.92
2’-O-Methyl-cytidine (N-iBu)
3’-[(Methyl)-(N,N-diisopropyl)]-phosphonamidite M.W. 774.88
2’-O-Methyl-guanosine (N-iBu)
3’-[(Methyl)-(N,N-diisopropyl)]-phosphonamidite M.W. 814.91
2’-O-Methyl-uridine
3’-[(Methyl)-(N,N-diisopropyl)]-phosphonamidite M.W. 705.78
2’-O-Methyl-cytidine (N-Ac)
3’-[(Methyl)-(N,N-diisopropyl)]-phosphonamidite M.W. 746.83

110764-77-7

250 mg

500mg

1g

2g

5g

$165.00$297.00$535.00$963.00$2,165.00$165.00$297.00$535.00$963.00$2,165.00$165.00$297.00$535.00$963.00$2,165.00$165.00$297.00$535.00$963.00$2,165.00$165.00$297.00$535.00$963.00$2,165.00

Standard RNA

ANP-8554

Protection

A
C
G
U
C

DNA Purification

Catalog #B

Modified DNA

N

Ancillary Reagents

2’-O-Methyl RNA Methyl Phosphonamidites with Standard
Base Protection

B
DMTrO

Modified RNA
RNA Purification

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK
Antisense

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

106

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
DNA Methyl Phosphoramidites with Labile (mild) Base Protection **

B
RO
O
O
P
N

CH3
O

B

Protection

Catalog#

DMTr
DMTr
DMTr
DMTr
MMTr
MMTr

A
C
G
T
A
G

N-PAC
N-PAC
N-tBPAC
N/A
N-PAC
N-tBPACANP-5531
ANP-5532
ANP-5533
ANP-3764
ANP-5536
ANP-5537

CAS No.

84416-85-3

Product Name

250mg

500mg

1g

2g

5g

ANP-5531

2’-Deoxy-Adenosine (N-PAC)
3’-methyl phosphoramidite, M.W.848.92
2’-Deoxy-Cytidine (N-PAC)
3’-methyl phosphoramidite, M.W. 824.90$30.00$54.00$97.00$175.00$395.00$30.00$54.00$97.00$175.00$395.00

2’-Deoxy-Guanosine (N-tBPAC)
3’-methyl phosphoramidite, M.W. 921.03
Thymidine
3’-methyl phosphoramidite, M.W. 705.78
5’-MMTr-2’-Deoxy-adenosine (N-PAC)
3’-methyl phosphoramidite, M.W. 818.90
5’-MMTr-2’-Deoxy-Guanosine (N-tBPAC)
3’-pethyl phosphoramidite, M.W. 891.00$30.00$54.00$97.00$175.00$395.00$20.00$36.00$75.00$145.00$263.00$30.00$54.00$97.00$175.00$395.00$30.00$54.00$97.00$175.00$395.00

ANP-5532
ANP-5533
ANP-3764
ANP-5536
ANP-5537**With proper care, using base labile protecting groups and Ammonia free deprotection solution, it is possible to synthesize P-Methoxy tri-ester oligonucleotides.
For Ammonia Free Oligo Deprotection Solution (Catalog # RN-1435) that can be used with methyl phosphoramidites with labile PAC protecting groups, refer to page 101.
For a discription of the advantages of using 5’-MMTr nucleoside phosphoramidites, please see page # 3.

B
DMTrO
O
O
P
N

Catalog #ANP-6901
ANP-6902
ANP-6903
ANP-6904O

DNA Isopropyl Phosphoramidites with standard Base
Protection***B

Protection

Catalog #CAS No.

A
C
G
T

N-Bz
N-Bz
N-iBu
N/A

ANP-6901
ANP-6902
ANP-6903
ANP-6904

153922-18-0

Product Name
2’-Deoxy-Adenosine (N-Bz)3’-isopropyl-phosphoramidite, M.W. 846.95
2’-Deoxy-Cytidine (N-Bz)3’-isopropyl-phosphoramidite, M.W. 822.92
2’-Deoxy-Guanosine (N-iBu)3’-isopropyl-phosphoramidite, M.W. 828.93
Thymidine3’-isopropyl-phosphoramidite, M.W. 733.83

250mg

500mg

1g

2g

5g

$45.00$80.00$144.00$260.00$585.00$45.00$80.00$144.00$260.00$585.00$45.00$80.00$144.00$260.00$585.00$45.00$80.00$144.00$260.00$585.00*** With proper care, using base labile protecting groups and Ammonia free deprotection solution, it is possible to synthesize P-Isopropoxy tri-ester oligonucleotides
conveniently.

107

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

DNA Purification

Catalog #Modified DNAR

2'-O-Alkyl
Modified
Amidites& Support/Antisense
Oligonucleotides
2’-O-Alkyl
Modifiedamidites& Support/ Antisense
Oligonucleotides

Ancillary Reagents

2’-O-(2-Butynyl) RNA Amidites with Standard Base Protection

B
DMTrO
O
O
P
N

ANP-7622
ANP-7623

ANP-7621
ANP-7622
ANP-7623
ANP-7625

Product Name
2’-O-(2-Butynyl)-Adenosine (N-Bz)
3’-CEP, M.W. 926.01
2’-O-(2-Butynyl)-Cytidine (N-Bz)
3’-CEP, M.W. 901.98
2’-O-(2-Butynyl)-Guanosine (N-iBu)
3’-CEP, M.W. 907.99
2’-O-(2-Butynyl)-Uridine
3’-CEP, M.W. 798.86

100µmole

250mg

500mg

1g

$185.00$450.00$810.00$1,450.00$185.00$450.00$810.00$1,450.00$185.00$450.00$810.00$1,450.00$185.00$450.00$810.00$1,450.00

2’-O-(2-Butynyl) RNA Supports with Standard Base
Protection

B
DMTrO

Modified RNA

OOOlcaa-CPG

O
O

B

Protection

Catalog #

A
C
G
U

N-Bz
N-Bz
N-iBu
N/A

N-9611
N-9612
N-9613
N-96142’-O-(2-Butynyl)-Adenosine (N-Bz)3’-lcaa CPG
2’-O-(2-Butynyl)-Cytidine (N-Bz)3’-lcaa CPG
2’-O-(2-Butynyl)-Guanosine (N-iBu)3’-lcaa CPG
2’-O-(2-Butynyl)-Uridine3’-lcaa CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

0.2

1.0

0.2

1.0

mg

µmole

µmole

µmole

µmole

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

Antisense

N-9611-05
N-9611-10
N-9612-05
N-9612-10
N-9613-05
N-9613-10
N-9614-05
N-9614-10

Product NameRNA Purification

Bulk CPG

Catalog #Standard RNA

ANP-7625

Catalog#

N-Bz
N-Bz
N-iBu
N/A

DNA Purification

ANP-7621

OCE

Protection

A
C
G
U

Modified DNA

Catalog #O

BStandard DNA

Oligo Synthesis Products

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

108

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl RNA Synthesis in Reverse Direction
2’-O-Methyl-5’-Phosphoramidites with Standard Base Protection
B
N

O
P
OCE
DMTrO

Catalog #

O
O-CH3

B

Protection

Catalog#

A
C
G
U
C

N-Bz
N-Bz
N-iBu
N/A
N-Ac

ANP-1012
ANP-1013
ANP-1014
ANP-1015
ANP-1019

Product Name

ANP-1012

2’-O-Methyl-adenosine (N-Bz)5’-CEP, M.W. 887.96
2’-O-Methyl-cytidine (N-Bz)5’-CEP, M.W. 863.93
2’-O-Methyl-guanosine (N-iBu)5’-CEP, M.W. 869.94
2’-O-Methyl-uridine5’-CEP, M.W. 760.85
2’-O-Methyl-cytidine (N-Ac)5’-CEP, M.W. 801.88

ANP-1013
ANP-1014
ANP-1015
ANP-1019

100µmole

250mg

500mg

1g

2g

$100.00$265.00$477.00$859.00$1,545.00$100.00$265.00$477.00$859.00$1,545.00$100.00$265.00$477.00$859.00$1,545.00$100.00$265.00$477.00$859.00$1,545.00$100.00$265.00$477.00$859.00$1,545.00

2’-O-Methyl-5-methyl-cytidine (N-Bz)-5’-CEP

2’-O-Methyl-5-methyl-uridine-5’-CEP

3’-O-DMT-2’-O-Methyl-5-Methyl-cytidine-(N-Bz)-5’-CEP

Catalog#Catalog#

ANP-1017

ANP-1016
O

NHBz

H3C

H3C

NH

N
N
N

O

O
P

O

OCE
DMTrO

O-CH3

C48H56N5O9P
Mol. Wt.: 877.9

PricingNN$126.00 / 100 μmole$320.00 / 250 mg$580.00 / 500 mg$1040.00 / 1 g

PricingO$126.00 / 100 μmole$375.00 / 250 mg$675.00 / 500 mg$1215.00 / 1 g

O
P

O

OCE
DMTrO

O-CH3

C41H51N4O9P
Mol. Wt.: 774

Purity: 98% +Purity: 98% +Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

109

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products
2'-O-Alkyl
2’-O-AlkylModified
ModifiedAmidites
amidites&&Support
Support/Antisense/ AntisenseOligonucleotides
Oligonucleotides

2’-O-Methyl-5’-Supports with Standard Base protection
B

OO
CPG-lcaa

O
O
DMTrO

O-CH3

Protection

Catalog #N-9912
N-9913
N-9914
N-9915
N-9919		
N-9916
N-9917

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N-Bz
N/A

Bulk CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

0.2

1.0

0.2

1.0

mg

µmole

µmole

µmole

µmole

$60

$65

$80

$130

$160

$60

$65

$80

$130

$160

$60

$65

$80

$130

$160

$60

$65

$80

$130

$160

$75

$75

$90

$150

$190

$75

$75

$90

$150

$190

$75

$95

$90

$150

$190
Modified RNA

2’-O-Methyl-adenosine (N-Bz)5’-lcaa CPG
2’-O-Methyl-cytidine (N-Bz)5’-lcaa CPG
2’-O-Methyl-guanosine (N-iBu)5’-lcaa CPG
2’-O-Methyl-uridine5’-lcaa CPG
2’-O-Methyl-cytidine (N-Ac)5’-lcaa CPG
2’-O-Methyl-5-Methyl-cytidine (N-Bz)5’-lcaa CPG
2’-O-Methyl-5-Methyl-uridine5’-lcaa CPG

100

Standard RNA

N-9912-05
N-9912-10
N-9913-05
N-9913-10
N-9914-05
N-9914-10
N-9915-05
N-9915-10
N-9919-05
N-9919-10
N-9916-05
N-9916-10
N-9917-05
N-9917-10

Product Namepack of 10 cols.

DNA Purification

Catalog #pack of 4 cols.

Modified DNA

A
C
G
U
C
5-Me-C
5-Me-U

B

Ancillary Reagents

2’-O-Methyl RNA Synthesis in Reverse Direction

RNA Purification

ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

Please Indicate Synthesizer when Ordering
Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands110

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
2’-O-Methyl Arabino Amidites with Standard Base protection

B
DMTrO
O

OCH3

O
P
N

OCE

B

Protection

Catalog#

A
C
C
G
U

N-Bz
N-Bz
N-Ac
N-iBu
N/A

ANP-1716
ANP-1717
ANP-1718
ANP-1719
ANP-1721

Catalog #Product Name

50μmole100μmole

250mg

500mg

1g

ANP-1716

2’-O-methyl-Arabino Adenosine (N-Bz)
3’-CEP, M.W. 887.96
2’-O-methyl-Arabino Cytidine (N-Bz)
3’-CEP, M.W. 863.93
2’-O-methyl-Arabino Cytidine (N-Ac)
3’-CEP, M.W. 801.86$70.00$126.00$355.00$675.00$1,215.00$70.00$126.00$355.00$675.00$1,215.00$70.00$126.00$355.00$675.00$1,215.00$70.00$126.00$355.00$675.00$1,215.00$70.00$126.00$355.00$675.00$1,215.00

ANP-1717
ANP-1718
ANP-1719

2’-O-methyl-Arabino Guanosine (N-iBu)
3’-CEP, M.W. 869.94
2’-O-methyl-Arabino Uridine
3’-CEP, M.W. 760.81

ANP-1721

Solid Supports for 2’-O-Methyl Arabino with Standard Base protection

B
DMTrO
O
OCH3
O
lcaa-CPG
O

B

Protection

Catalog #

A
C
C
G
U

N-Bz
N-Bz
N-Ac
N-iBu
N/A

N-7423
N-7424
N-7425
N-7426
N-7427O

Catalog #N-7423-05
N-7423-10
N-7424-05
N-7424-10
N-7425-05
N-7425-10
N-7426-05
N-7426-10
N-7427-05
N-7427-10

Product Name
2’-O-methyl-Arabino Adenosine(N-Bz)-3’-lcaa CPG
2’-O-methyl-Arabino Cytidine(N-Bz)-3’-lcaa CPG
2’-O-methyl-Arabino Cytidine(N-Ac)-3’-lcaa CPG
2’-O-methyl-Arabino Guanosine(N-iBu)-3’-lcaa CPG
2’-O-methyl-Arabino Uridine3’-lcaa CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$70

$630

$100

$200

$200

$400

$70

$630

$100

$200

$200

$400

$70

$630

$100

$200

$200

$400

$70

$630

$100

$200

$200

$400

$70

$630

$100

$200

$200

$400

2’-O-Methyl-arabino-amidites are covered by ChemGenes patent, U.S. Patent#. US20120149888
ChemGenes is offering the novel modifications for the Synthesis of 2’-O-Methyl-arabino Nucleosides, Phosphoramidites and Oligonucleotides
for Biological Application in Therapeutics, Diagnostics, G-tetrad Forming Oligonucleotides and Aptamers etc.

111

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides

Ancillary Reagents

CombiClickTM Chemistry Products2’-O-Propargyl Amidites with Standard Base Protection
B
DMTrO
O
O
P

OCE

Catalog #Protection

Catalog#

A
C
G
U
C
I

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N/A

ANP-7751
ANP-7752
ANP-7753
ANP-7754
ANP-7756
ANP-6191

Product Name

ANP-7751

250mg

500 mg1g$185.00$490.00$880.00$1,584.00

ANP-7752$185.00$490.00$880.00$1,584.00

ANP-7753$185.00$490.00$880.00$1,584.00

ANP-7754$185.00$490.00$880.00$1,584.00

ANP-7756$185.00$490.00$880.00$1,584.00

ANP-6191$185.00$490.00$880.00$1,584.00
Standard RNA

2’-O-Propargyl Supports with Standard Base Protection
B
DMTrO
O
O

O

O
Catalog #Catalog #

N-Bz
N-Bz
N-iBu
N/A
N-Ac
N/A

N-8910N-8920N-8930N-8940N-8960N-8970

Product Name

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100

0.2

1.0

0.2

1.0

mg

µmole

µmole

µmole

µmole

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

Antisense2’-O-Propargyl-adenosine (N-Bz)3’-lcaa CPG
2’-O-Propargyl-cytidine (N-Bz)3’-lcaa CPG
2’-O-Propargyl-guanosine (N-iBu)3’-lcaa CPG
2’-O-Propargyl-uridine3’-lcaa CPG
2’-O-Propargyl-cytidine (N-Ac)3’-lcaa CPG
2’-O-Propargyl-inosine3’-lcaa CPG

Pore Size

RNA Purification

N-8910-05
N-8910-10
N-8920-05
N-8920-10
N-8930-05
N-8930-10
N-8940-05
N-8940-10
N-8960-05
N-8960-10
N-8970-05
N-8970-10

Protection

A
C
G
U
C
I

Modified RNA

lcaa-CPGO

B

DNA Purification

100µmole

2’-O-Propargyl-adenosine (N-Bz)3’-CEP, M.W. 911.98
2’-O-Propargyl-cytidine (N-Bz)3’-CEP, M.W. 887.96
2’-O-Propargyl-guanosine (N-iBu)3’-CEP, M.W. 893.96
2’-O-Propargyl-uridine3’-CEP, M.W. 784.83
2’-O-Propargyl-cytidine (N-Ac)3’-CEP, M.W. 825.89
2’-O-Propargyl-inosine3’-CEP, M.W. 810.89

Modified DNA

N

O

B

The Propargyl Amidites Products are covered under ChemGenes patent, U.S. Patent#. 5,744,595
CombiClick™ is the term coined by ChemGenes for Solid Support Based Combinatorial “Click Chemistry” for Efficient Oligonucleotide Conjugation: This is a versatile method for Oligonucleotide Labeling;
N. Srivastava and S. Srivastava, A. Laikhter. J Biomol Tech. 2010 September; 21 (3 Suppl) S44.

112

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

We have developed a method for efficient attachment of a variety of dyes to the oligonucleotide backbone in nearly quantitative yields (95-98%). This approach allows the synthesis of multiply labeledoligonucleotides in combinatorial fashion during oligonucleotide synthesis on solid support.

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
CombiclickTM Chemistry Products

3’-O-Propargyl Amidites with Standard Base Protection
B
B
A
C
G
U
C

DMTrO
O
O
P

O
CEO

Catalog #N

Catalog#
ANP-9751
ANP-9752
ANP-9753
ANP-9754
ANP-9759

100µmole

250mg

500 mg

1g

2g

ANP-9751

3’-O-Propargyl-adenosine (N-Bz)2’-CEP, M.W. 911.98$185.00$490.00$880.00$1,584.00$2,850.00

ANP-9752

3’-O-Propargyl-cytidine (N-Bz)2’-CEP, M.W. 887.96
3’-O-Propargyl-guanosine (N-iBu)2’-CEP, M.W. 893.96
3’-O-Propargyl-uridine2’-CEP, M.W. 784.83
3’-O-Propargyl-cytidine (N-Ac)2’-CEP, M.W. 825.89$185.00$490.00$880.00$1,584.00$2,850.00$185.00$490.00$880.00$1,584.00$2,850.00$185.00$490.00$880.00$1,584.00$2,850.00$185.00$490.00$880.00$1,584.00$2,850.00

ANP-9753
ANP-9754
ANP-9759

Product Name

Protection
N-Bz
N-Bz
N-iBu
N/A
N-Ac

3’-O-Propargyl Supports with Standard Base
Protection

B
DMTrO
O
O

O

lcaa-CPGOOCatalog #N-9881-05
N-9881-10
N-9882-05
N-9882-10
N-9883-05
N-9883-10
N-9884-05
N-9884-10
N-9889-05
N-9889-10

Product Name
3’-O-Propargyl-adenosine (N-Bz)2’-lcaa CPG
3’-O-Propargyl-cytidine (N-Bz)2’-lcaa CPG
3’-O-Propargyl-guanosine (N-iBu)2’-lcaa CPG
3’-O-Propargyl-uridine2’-lcaa CPG
3’-O-Propargyl-cytidine (N-Ac)2’-lcaa CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

B

Protection

Catalog #

A
C
G
U
C

N-Bz
N-Bz
N-iBu
N/A
N-Ac

N-9881
N-9882
N-9883
N-9884
N-9889Bulk CPG
cols.

pack of 4 cols.

pack of 10

100

0.2

1.0

0.2

1.0

mg

µmole

µmole

µmole

µmole

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

$65

$80

$95

$160

$190

The above Products are covered under ChemGenes patent, U.S. Patent No. 5,744,595
113

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides

Ancillary Reagents

CombiclickTM Chemistry Products
2-O-Propargyl-abasic-phosphoramidite

2’-O-Propargyl-Arabino inosine-3’-CEP(2- -Propargyl-1,1-dihydro-D-ribose-3-CEP)

Catalog#Catalog#O

ANP-9782

N

Pricing

DMTrO
O
O
P
N

DMTrO

OCE

P
N

Bulk CPG

Pore Size

2’-O-Propargyl-abasic-ribose
3’-lcaa CPG

500Å
1000Å

Purity: 98% +pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$110

$970

$110

$180

$220

$360

Standard RNA

N-9784-05
N-9784-10

Product NameOCE

C43H49N6O8P
Mol. Wt.: 808.86

Purity: 98% +2’-O-Propargyl Abasic Supports & Columns
Catalog #$180.00 / 50 μmole$320.00 / 100 μmole$890.00 / 250 mg$1600.00 / 500 mg

O

DNA Purification

C38H47N2O7P
Mol. Wt.: 674.

PricingOO$85.00 / 50 μmole$150.00 / 100 μmole$495.00 / 250 mg$890.00 / 500 mg

O

ANP-9851

NH
N

Modified DNA

N

Modified RNA
RNA Purification

ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

Please Indicate Synthesizer when Ordering
Akta OligopilotAKwww.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands114

Oligo Synthesis Products2’-O-Alkyl Modified amidites & Support / Antisense Oligonucleotides
CombiclickTM Chemistry Products contd..
2-O-Hexynyl-Abasic-Phosphoramidite

2’-O-Hexynyl-inosine-3’-CEP(2-O-Hexynyl-1,1-dihydro-D-ribose-3-CEP)

Catalog#Catalog#O
NNH

ANP-9781

ANP-9852
DMTrO

N

N

DMTrO

Pricing

O
O
P
N

O

O
OCE

C46H55N6O8P
Mol. Wt.: 850.94

OP$120.00 / 50 μmole$215.00 / 100 μmole$560.00 / 250 mg$1020.00 / 500 mg

N

PricingO$85.00 / 50 μmole$150.00 / 100 μmole$465.00 / 250 mg$835.00 / 500 mg

OCE

C41H53N2O7P
Mol. Wt.: 716.84

Purity: 98% +Purity: 98% +CombiClickTM Chemistry Products

Several azido modified reporter molecules such as Fluorescein, Lissamine, Cy3, Cy5, Ferrocene, and New quencher dye Instant Quencher (IQ2TM),
that is develped by ChemGenes, have been synthesized and tested in CombiClickTM attachment chemistry. This approach allows the synthesis ofmultiply labeled oligonucleotides in combinatorial fashion during oligonucleotide synthesis on solid support. In the case of multiply labeled oligonucleotides, each step of CombiClickTM attachment can be performed independently after incorporation of the corresponding propargyl base.

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

115

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
Phosphoramidites

ChemGenes offers a variety of chromphores and ligands for developing modified synthetic oligonucleotides conjugated with reportermolecules which can be employed in hybridization-based assays. Such oligonucleotides have broad applications in both basic molecular biology research and in clinical diagnostics and screening, because they have high specificity to a target nucleic acid sequence.

A wide variety of ligands are available from ChemGenes. The most common modification used for selective oligonucleotide attachment is the alkyl amino group. We offer from C-3 to C-12 spacer amino modifiers. This modification can be introduced into an oligonucleotide by using the corresponding phosphoramidite building block with the protected alkyl amine, which enabled for the reaction
with activated esters after removal of the protecting group.1,2

Standard RNA

Sulfhydryl modification reagents and supports are offered by us. This is a very efficient functionality utilized in the Michael-addition andnucleophilic substitution reactions with different electrophiles. It was successfully employed in chemoselective bio-molecule conjugations.8,9 That modification can be introduced by several thioate and disulfide containing phosphoramidites and solid supports sold by us.

DNA Purification

Amongst various other chemistries available in literature by different approaches such as introduction of the desired alkyl amino
function by aminolysis of the ester bond by diamino alkanes.3,4 The reaction of alkyl amino modified oligonucleotides and activated esters affords the amide bond between an oligonucleotide and molecule of interest. Similarly hydrazides have been usedin selective reaction with active esters. That type of nucleophilic modifications attached to the oligonucleotides and some of theirapplications have been recently reported in the literature.5,6 It also has been shown that hydrazide forms a stable Schiff base in
the reaction with aldehydes and for some applications does not require reduction into stable alkyl hydrazide by cyanoborohydride.7

Modified DNA

Ligands for attachment Chemistries

Ancillary Reagents

Chromophores & Ligands

Standard DNA

Oligo Synthesis Products

References

RNA Purification

7.
8.
9.

Connolly, B. A. Nucl. Acids Res. 1987, 15, 3131-3139.
Coull, J. M.; Weith, H. L.; Bischoff, R. Tet. Lett. 1986, 27, 3991-3994.
Hovinen, J.; Gusaev, A.; Azhaev, A.; Lönnberg, H. J. Chem. Soc. Perkin Trans. I, 1994, 2745-2749.
Azhaeva, E.; Azhaev, A.; Gusaev, A.; Hovinen, J.; Lönnberg, H. Nucl. Acid Res. 1995, 23, 1170-1176.
Ghosh, S. S.; Kao, P. M.; Kwoh, D. Y. Analytical Biochemistry 1989, 178, 43-51.
Raddatz, S.; Mueller-Ibeler, J.; Kluge, J.; Wäß, L.; Burdinski, G.; Havens, J. R.; Onofrey, T. J.; Wang, D. and Schweitzer, M. Nucl.
Acids Res. 2002, 30, 4793-4802.
Podyminogin, M. A.; Lukhtanov, E. A.; Reed, M. W. Nucl. Acids Res. 2001, 29, 5090-5098.
Jablonski et al. Nucl. Acids Res. 1986, 14, 6115.
Farmer, G. J.; Castenada, M. Biotechniques, 1991, 11, 588.

Modified RNA

1.
2.
3.
4.
5.
6.

Antisense

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

116

Phosphoramidites
and Supports
for Introducing
Chromophores& Ligands
Phosphoramidites
and Supports
for Introducing
Chromophores& Ligands
Summary of Chromophore & Ligand Modified Phosphoramidites
The incorporation of the chromophores and lingands are summarized below:

Phosphate Introducing Reagents
Bis- Cyanoethyl-N,N-diisopropyl Amidite and Phosphate-ON (generates DMTr color) Reagents

Amino Linkers

Includes TFA-Amino-C4, TFA-Amino-C5, TFA-Amino-C6, MMTr-Amino-C6, dC N4-Amino Linker, MMT-Amino-C12, TFA-Amino-C12,
Amino-dT-C6, & Fmoc-Amino-DMTr-C3 Amidites and various supports, ssR-Me/ssH amino modifiers.

Spacers

Includes C2, C3, C4, C6, C9 and C12 spacers, Spacer 9, Spacer 12, Spacer 18, Polyethyleneglycol 2000, and Polyethyleneglycol
4500

5’-Thiol & 3’-Thiol Modifiers

Includes 5’-Thio Modifier Hexyl, 5’-Thiol C3 Disulfide , and 5’ Thiol C6 Disulfide amidites and 3’-Thiol Modifier C6 support. Cyclic
Disulfide Dithiolane phosphoramidite and Supports.

BiotinIncluding Biotin BB, Biotin Phosphoramidites

Branching Amidites and Supports

Asymmetrical and Symmetrical Branching, Glyceryl CPG, & Butanol CPG

Carboxy Introduction and Cholesterol

Including Thymidine-succinyl-hexamide Amidite, Deoxyuridine-5-methylacrylate Amidite, Cholesterol TEG(generating DMT-orange
color), TEG Cholesterol, & Cholesterol Supports.

Dabcyl and DNP-TEG

Including Dabcyl Amidites and Supports ,Thymidine-C5-dabcyl Amidite, and DNP-TEG Amidites

Etheno Amidites & Supports
HEX,TET,6-FAM , 5-FAM, Fluorescein-dT, and Tetrachloro, Hexachloro Fluorescein Cyclohexyl Amidites & Supports
Includes N4 6-TAMRA Amidites and Support & 5-TAMRA Amidite

Psoralen Amidites & Supports
Includes Psoralen Amidites, Psoralen-C2, Psoralen-C4, Psoralen-C6, Psoralen-hexaethyloxyglycol, and Psoralen CPG

TAMRA Amidites & Supports and Cocktail for TAMRA

Includes N4-6-TAMRA Amidites and Supports & 5-TAMRA Amidite

117

Toll(800)
Free: (800)762-9323
Toll Free:762-9323

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramidites
andSupports
Introducing
Chromophores
Ligands
Phosphoramidites
andSupports
forforIntroducing
Chromophores&&
Ligands

Standard DNA

Oligo Synthesis Products
Chemical Phosphorylation & Supports
5’-Phosphorylation Reagent (generates DMT color)(Bis-Cyanoethyl-N,N-diisopropyl Phosphoramidite)(5-Phosphate-ON Reagent)

Catalog#Catalog#
CLP-1454

CLP-1544

PricingCEOO

CEO
C12H22N3O2P
Mol. Wt.: 271

O
S

DMTrO

C34H45N2O7PS
Mol. Wt.: 656.77

Purity: 98% +Pricing$45.00 / 100 μmole$150.00 / 250 mg$270.00 / 500 mg$485.00 / 1 g

Purity: 98% +Modified DNA$40.00 / 100 μmole$300.00 / 250 mg$480.00 / 500 mg$760.00 / 1 g

P N

OCE
P
O
N

Ancillary Reagents

5’-Phosphorylation Reagent

3’- Phosphate-ON CPG
DNA Purification

O

O
S
DMTrO

O
lcaa CPGO
O

Phosphate-ON Succinyl lcaa Supports & Columns
Catalog #3’-Phosphate-ON
lcaa CPG

Pore Size
500Å
1000Å
2000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$62

$425

$52

$92

$104
$184
				

Oligonucleotides can be phosphorylated enzymatically at the 5’-terminus by polynucleotide kinase. This reaction is reversible and isdifficult to control. For applications such as gene assembly, where complete phosphorylation is important, it is advisable to introduce
the phosphate chemically.

RNA Purification

ChemGenes offers two reagents for 5’-phosphorylation of an oligonucleotide:• The bis-cyanoethyl-N,N’-diisopropyl phosphoramidite (catalog #: CLP-1454) quantitatively phosphorylates the 5’-hydroxyl group
via phosphoramidite methodology on an automatic DNA/RNA synthesizer.
• An alternative is the 5’-Phosphate-ON Reagent (catalog #: CLP-1544) which generates a “DMT orange color” after introduction ofphosphate at the last nucleotide in the oligonucleotide chain.

Modified RNA

N-9977-05
N-9977-10
N-9977-20

Product Name

Bulk CPG

Standard RNA

N-9977-05/10/20

Description:www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

5-Phosphate-ON-reagent is an alternative to Bis-cyanoethyl phosphorylating reagent, outlined above. This reagent generates DMTr
orange color after introduction of phosphate at the last nucleoside in the oligonucleotide chain.
118

Antisense

Bis-Cyanoethyl-N,N’-diisopropyl CEP is used for the introduction of 5’- terminal phosphate on a synthetic DNA/RNA via phosphoramidite chemistry on an automatic DNA Synthesizer to produce probes and primers carrying 5’-phosphate. This is an ideal reagent forthe production of phosphorylated DNA or RNA oligomers in large quantity, as compared to enzymatic phosphorylation at this position,
which has limitations with respect to the quantities. This becomes a significant factor when large quantities of phosphorylated oligomers
are required for recombinant DNA applications. The bis-cyanoethyl phosphoramidite reagent has the disadvantage of not generating
any color, however due to its lower price it is the reagent of choice for the production of phophorylated DNA or RNA oligomers in large
quantities

Phosphoramidites
Phosphoramiditesand
andSupports
SupportsforforIntroducing
IntroducingChromophores
Chromophores& &Ligands
Ligands
Amino Modifiers & Supports
5’-Amino (TFA)-Modifier-C4 spacer CEP

5’-Amino (TFA)-Modifier-C5 spacer CEP

Catalog#Catalog#

CLP-1453

O
F3C

CLP-1357

PricingO
N
H

O$48.00 / 100 μmole$170.00 / 250 mg$300.00 / 500 mg$540.00 / 1 g

N
P
OCE

C15H27F3N3O3P
Mol. Wt.: 385.36

F3C

Pricing

OCE
P
O
N

N
H

$30.00 / 100 μmole$90.00 / 250 mg$160.00 / 500 mg$285.00 / 1 g

C16H29F3N3O3P
Mol. Wt.: 399.39

Purity: 98% +Purity: 98% +5’-Amino (TFA)-modofier-C6 spacer CEP
Catalog#Catalog#

CLP-1553

CLP-1563

PricingO
O
F3C

5’-Amino (MMTr)-modifier-C6 spacer CEPN
HPricing$28.00 / 100 μmole$84.00 / 250 mg$150.00 / 500 mg$270.00 / 1 g

N
P
OCE

C17H31F3N3O3P
Mol. Wt.: 413.42

MMTr

O

N

N
H

P
OCE
C35H48N3O3P
Mol. Wt.: 589.75

Purity: 98% +$56.00 / 100 μmole$190.00 / 250 mg$340.00 / 500 mg$610.00 / 1 g

Purity: 98% +CAS No. 114616-27-2

Amino-(Spacer-7) lcaa Supports & Columns
H2N

O

ODMTr
O
lcaa-CPG

O

N-1577-05/10

O

Bulk CPG

Catalog #N-1577-05
N-1577-10

Product Name
Amino-(Spacer-7)
lcaa CPG

Pore Size
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$62

$425

$52

$92

$104
$184
			

MMTr-Amino & TFA-Amino C-12 CEP, Fmoc amino C6 & spacer 7 CEP: Please see Page 118.
2’-O-Methyl amino modifier: Please see Page 94 (ANP-2583 / ANP2581).

119

Toll Free: (800) 762-9323
Toll Free:(800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
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Phosphoramidites
Supports
Introducing
Chromophores& Ligands
Phosphoramidites
andandSupports
for forIntroducing
Chromophores& Ligands

Standard DNA

Oligo Synthesis Products
Amino Modifiers & Supports

Ancillary Reagents

Amino-modifier-13-atom-Spacer-dC
CEP;
4(Deoxy Cytidine N Amino Linker Phosphoramidite)

Catalog#
CLP-1329

Pricing
Modified DNA$150.00 / 100 μmole$325.00 / 250 mg$585.00 / 500 mg$1050.00 / 1 g

Purity: 98% +Catalog#
CLP-1131

Pricing

US7491857B2; Y. Komatsu; N. Kojima; K. Sato;
Ken Nonaka; Y. Fujiwana

Standard RNA$84.00 / 100 μmole$270.00 / 250 mg$485.00 / 500 mg$870.00 / 1 g

For synthesis of amino linker oligo nucleotideproves in which the amino group possessenhanced reactivity towards various amine
reactive dyes for conjugation.

DNA Purification

ssR-Me Amino Modifier

Purity: 98% +ssH Amino Modifier
Catalog#
Modified RNA

CLP-1132

Pricing$84.00 / 100 μmole$275.00 / 250 mg$495.00 / 500 mg$890.00 / 1 g

5’-Terminal Amino Introducing ReagentsThe standard DNA synthesis protocols are followed to quantitatively generate the primary aliphatic amino group. This primary aliphatic amino group is useful for the subsequent introduction of various functional entities such as following:• Biotin• Fluorescent molecules• Alkaline phosphatase enzyme, amino acids, hydrophobic moities etc.

The 5’-Terminal amino Introducing Reagent such as C4 Spacer (TFA-amino C4, Catalog# CLP-1453), C5 Spacer (Catalog# CLP-1357), C6 Spacer (Catalog# CLP-1553)
allows only for a single primary amino function per molecule. The amino group is introduced while protected as trifluoroacetamido which is cleaved during ammonia deprotection of the oligo. The 5’-Terminal Amino Introducing Reagents allow for introduction of C4, C5 and C6 spacer respectively between the 5’-phosphate and the terminallyintroduced primary amino group.

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Chromophores &Ligands

120

Antisense

The primary aliphatic amino group reacts very smoothly with a wide variety of labeling reagents; thus it is the chemical modification of choice for this application. Thus
covalently linked chromophores can be readily introduced in a synthetic DNA or RNA of interest. (Nelson, P. S.; Gold, R. S.; Leon, R. Nucl. Acids Res. 1989, 17, 7179).

RNA Purification

Purity: 98% +Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
Amino Modifiers & Supports
5’-Amino (MMTr)-Modifier-C12 spacer CEP

2,7-di-tert-butyl-(Fmoc)-aminobutyrylglyceryl- Phosphoramidite
Catalog#
CLP-1585

Pricing
MMTr

O
N
H

N
P
OCE

C41H60N3O3P
Mol. Wt.: 673.91$90.00 / 100 μmole$275.00 / 250 mg$495.00 / 500 mg$890.00 / 1 g

Purity: 98% +Catalog#

5’-Amino (TFA)-Modifier-C12 spacer CEP

CLP-1666

Catalog#
CLP-1575

Pricing

O
F3C

O
N
H

N
P
OCE

C23H43F3N3O3P
Mol. Wt.: 497.57$90.00 / 100 μmole$275.00 / 250 mg$495.00 / 500 mg$890.00 / 1 g

Pricing$210.00 / 250 mg$335.00 / 500 mg$535.00 / 1 g

Purity: 98% +Purity: 98% +5’-Amino (Fmoc)-Modifier-C6 spacer CEP
Catalog#
CLP-1586
Fmoc

O
N
H

Pricing

N
P
OCE$90.00 / 100 μmole$375.00 / 250 mg$675.00 / 500 mg$1210.00 / 1 g

C30H42N3O4P
Mol. Wt.: 539.65

Purity: 98% +5’-Amino (Fmoc)-Modifier-spacer (7 atoms) CEP
Catalog#
Fmoc
N
H

O

ODMTr
OCE

O
P
N

C51H60N3O8P
Mol. Wt.: 874.01

CLP-1662

Pricing

MMTr-Amino C6 & C12 Modifiers

The 5’-Terminal Introducing Reagent with C6 Spacer (MMTramino-C6 spacer phosphoramidite, Calatog# CLP-1563) and the5’-Terminal amino introducing Reagent with C12 Spacer (MMTramino-C6 phosphoramidite, Catalog# CLP-1585) are used to introduce a primary amino group at the 5’-terminal of an oligonucleotide.
The MMTr on the amino function is cleaved with 3% trichloracetic
acid (TCA), similar to DMTr removal in oligonucleotide synthesis.
However, the MMTr-group removal is significantly slower (12 minutes
contact with TCA).
A useful utilization of MMTr protected C6 and C12 phosphoramidites
involves the selective cleavage of the MMTr group from the synthesized oligonucleotide to obtain the free terminal amino function while
the oligo is still bound to the solid support. Various chomophores andbiologyically significant molecules can be coupled to the terminal
amino group of the support bound oligonucleotide. As it is a solid
phase synthesis the excess reagent (chromophores) can easlily be
washed off, thus leaving almost pure chomophore-oligonucleotide$90.00 / 100 μmole$240.00 / 250 mg$430.00 / 500 mg$775.00 / 1 g

Purity: 98% +
121

Toll
Free:
(800)762-9323
762-9323
Toll
Free:
(800)

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products
Phosphoramidites
Supports
for Introducing
Chromophores& Ligands
Phosphoramidites
and and
Supports
for Introducing
Chromophores& Ligands
Amino Modifiers & Supports
3’-Amino (Fmoc)-modifier-C3 CEP

Amino Modifier Thymidine (total 10 atoms spacer) CEP

Catalog#
O

O
HN

H
N

Fmoc
ODMTr

N
H

O

O
P

Pricing

DMTrO

CEO

O
P
OCE

CLP-1661

PricingN

C48H54N3O7P
Mol. Wt.: 815.93

Modified DNA$175.00 / 100 μmole$410.00 / 250 mg$735.00 / 500 mg$1320.00 / 1 g

O

NCatalog#

CLP-1501

CF3

N
H
N

O

Ancillary Reagents

Amino-modifier-C6-dT CEP$48.00 / 100 μmole$130.00 / 250 mg$200.00 / 500 mg$320.00 / 1 g

Purity: 98% +C50H62F3N6O10P
Mol. Wt.: 995.03

DNA Purification

Amino Introducing Reagent with C3 Spacer (Fmoc-amino-DMTr C3 phosphoramidite) & Amino-dT

The amino introducing reagent with C3 Spacer (Fmoc-amino-DMT C3 phosphoramidite, Catalog# CLP-1661) has a DMT group in additon to the protected primary aminogroup. This DMT group facilitates monitoring the efficiency of the phosphoramidite coupling and also allows multiple additions of the amino function. The amino dT, with a
total spacer arm of 10 atoms, is suitable for the internal labeling of oligonucleotides.

Supports & Columns for 3’-amino linker oligonucleotides

O

O

HN
O

N
H

O
N
H

CF3

O

N

6N

O
DMTrO

N

O

DMTrO
O

N

O

CF3

H

3 N

DMTrO

NH

NHFmoc

H

O

O

CF3

O

O

N

lcaa-CPG

lcaa-CPGO

lcaa-CPG

O
O

O

O

O

CPG-lcaa

O

O

O
O
O

O

O

DMTrO

lcaa-CPG

Standard RNA

O
O
O
HN

NHTr

O
O

N-6054-05/10

N-8024-05/10

N-9750-05/10

N-1004-05/10

Supports & Columns for 3’-amino linker oligonucleotides
Bulk CPG

Catalog #Product Name

N-1004-13

Polymeric Support

500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
300Å
1000Å

pack of 10 cols.

250

1

0.2

1.0		

0.2

1.0

mg

mg

g

µmole

µmole		

µmole

µmole

$120

$180

$240

$360

$140

$180 $585
		$150 $550

$88

$112

$176

$224

$140

$170

$570

$110

$170

$220

$340

$140

$170

$570

$110

$170

$220

$340

$140

$170

$570

$110

$170

$220

$340

$140

$170

$570

$110

$170

$220

$340			

$140

Antisense3’-Amino (TFA)-modifierSpacer 7-lcaa CPG
3’-Amino (Fmoc) modifier C3lcaa CPG
Amino-modifier-Spacer-13-dClcaa CPG
Amino-modifier-C6-dTlcaa CPG
3’-Amino (trityl)-modifier-dT
CPG
3’-Amino (TFA)-modifier-spacer 6-

pack of 4 cols.

100

RNA Purification

N-1004-05
N-1004-10
N-9750-05
N-9750-10
N-6052-05
N-6052-10
N-6054-05
N-6054-10
N-8024-05
N-8024-10

Pore Size

Modified RNA

N-6052-05/10

3’-Amino Modifier

The 3’-amino modifer TFA-C6 (Catalog# N-1004) has been found to be a very useful addition to 3’-amino linked DNA/RNA chimeras and micro RNA (Quintana, L. et. al.
Current Biology 2002, 12, 735-739).

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Email: info@chemgenes.com

Chromophores &Ligands122

Phosphoramidites and Supports for Introducing Chromophores & Ligands
Amino Modifiers & Supports
Amino-Modifier-C6-Phthalamido-TEA Salt

Catalog#
CLP-1328

Pricing$115.00 / 100 μmole$360.00 / 250 mg$640.00 / 500 mg$1150.00 / 1 g

Purity: 98% +3’-Amino-Phthalamido Modifier CPG

3’-Amino (Fmoc)-Modifier (C6 spacer) CPG

N-8217-05/10

N-1005-05/10

Supports & Columns for 3’-amino linker oligonucleotides
Catalog #N-8217-05
N-8217-10
N-1005-05
N-1005-10

Product Name

Pore Size

3’-Amino-modifier-C6 phthalamidolcaa CPG
3’-Amino modifiers (Fmoc)
C7 lcaa CPG

500Å
1000Å
500Å
1000Å

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100

250

1

0.2

1.0

0.2

1.0

mg

mg

g

µmole

µmole

µmole

µmole

$90

$180

$585

$120

$180

$240

$360

$90

$180

$585

$120

$180

$240

$360

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

123

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramidites
andandSupports
for Introducing
Chromophores& Ligands
Phosphoramidites
Supports
for Introducing
Chromophores& Ligands

Standard DNA

Oligo Synthesis ProductsSpacer Modifiers & Supports(C2 Spacer)

DMTr-O-Hexyl 6-Phosphoramidite(C6 Spacer)

Catalog#

DMTrO

Catalog#

CLP-2250

OCE
P
O
N

CLP-1120

Pricing
DMTrO$75.00 / 100 μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g

Pricing

OCE
PO
N$75.00 / 100 μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g

C36H49N2O5P
Mol. Wt.: 620.76

Purity: 98% +DMTr-O-Butyl 4-Phosphoramidite

Purity: 98% +Modified DNA

C32H41N2O5P
Mol. Wt.: 564

Ancillary Reagents

DMTr-O-Ethyleneglycol phosphoramidite

DMTr-O-Nonyl 9-Phosporamidite(C4 Spacer)(C9 Spacer)

DMTrO
O

OCE

CLP-9775

P

Pricing

N

C34H45N2O5P
Mol. Wt.: 592.71

DMTrO

Pricing$75.00 / 100 μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g

C39H55N2O5P
Mol. Wt.: 662.84

Purity: 98% +Purity: 98% +DMTr-O-Propyl 3-Phosphoramidite

DMTr-O-Dodecyl 12-Phosphoramidite(C3 Spacer)(C12 Spacer)

Catalog#
OCEPON

C33H43N2O5P
Mol. Wt.: 578.68

Catalog#

CLP-9908

CLP-1114

Pricing$75.00 / 100 μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g

Pricing

OCE
P
O
N

DMTrO

$75.00 / 100 μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g

C42H61N2O5P
Mol. Wt.: 704.92

Purity: 98% +Supports & Columns for Phthalamido
Catalog #Pore Size

1-O-DMTr-propyl-3-O-succinyllcaa CPG
1-O-DMTr-butyl-4-O-succinyl
Polymeric Support

Butyl CPG; DMTr-butanol-Icaa CPG(for 3’-butanol Spacer)
Glyceryl CPG (for 3’-Glyceryl Spacer)

500Å
1000Å
300Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

0.2

1.0

pack of 10 cols.

0.2

1.0

g

µmole

µmole

µmole

µmole

$180

$585

$120

$180

$240

$360

$180

$585

$120

$180

$240

$360

$140 $180

$585

$120

$180

$240

$360

$140

$585

$120

$180

$240

$360				100Bulk CPG

250

1

mg

mg

$140
$140

$180

Antisense

N-1089-05
N-1089-10
N-9168-05
N-9168-10
N-7178-05
N-7178-10
N-7175-05
N-7175-10

Product NameRNA Purification

Purity: 98% +Modified RNA

DMTrOStandard RNA$75.00 / 100 μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g

CLP-9009

OCE
P
O
N

DNA Purification

Catalog#Catalog#

The DMTr- -butyl phosphoramidite (catalog # CLP-9775) introduces the butanediol moiety (single or mutliple units) into an oligonucleotide. The butanediol spacer has been
incorporated in oligonucleotides consisting of 2’,5’-A and DNA segents to produce oligonucleotide chimeras that catalyze selective cleavage of RNA in human cells. (a) Maitra,
R. K.; Li, G.; Xiao, W.; Dong, B.; Torrence, P. F.; Silverman, R. H. J. Biol. Chem. 1995, 270, 15071. (b) Lesiak, K.; Khamnei, S.; Torrence, P. F. Biocon. Chem. 1993, 4, 467.

124

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Email: info@chemgenes.com

Chromophores &Ligands

The corresponding CPG is also available to incorporate this unit at the 3’-end of an oligo.

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
Spacer Modifiers & Supports
DMTr-O-Triethyleneglycol Phosphoramidite

DMTr-O-Tetraethyleneglycol Phosphoramidite

Catalog#Catalog#

CLP-1113

CLP-1368(Spacer 12)(Spacer 9)

Pricing

OCE
P
O
N

O
DMTrO

$80.00 / 100 μmole$150.00 / 250 mg$225.00 / 500 mg$450.00 / 1 g

2

C36H49N2O7P
Mol. Wt.: 652.76

OCE
P
O
N

O
DMTrO
3

C38H53N2O8P
Mol. Wt.: 696.81

DMTr-O-Polyethyleneglycol 4500 Phosphoramidite

DMTr-O-Hexaethyleneglycol Phosphoramidite(Avg. M.W.~4500)

Catalog#Catalog#

CLP-9765

OCE
P
O
N

DMTrO
5

C42H61N2O10P
Mol. Wt.: 784.91

CLP-3118

Pricing$80.00 / 100 μmole$150.00 / 250 mg$225.00 / 500 mg$450.00 / 1 g

OCE
P
O
N

O
DMTrO

n
n=90

O

Ethyl-diethyleneglycol phosphoramidite
Catalog#

CLP-2119Onn=44
C120H217N2O49P
Mol. Wt.: 2502.96

O$265.00 / 100 μmole$515.00 / 500 mg$930.00 / 1 g

C15H31N2O4P
Mol. Wt.: 334.39

Pricing$275.00 /100μmole$340.00 / 250 mg$480.00 / 500 mg$600.00 / 1 g

Palmitoyl Polymeric Support
Catalog#N-9821-03

CLP-8508

OCE
O P
N

125

CLP-3119

Purity: 98% +Purity: 98% +Catalog#

C25H53N2O4PSi
Mol. Wt.: 504.76

OCE
P
O
N

Pricing

TOM-C6 Phosphoramidite

TOM-O$275.00 / 100 μmole$540.00 / 1 g

Mol. Wt. Avg: ~4500 Purity: 98% +Catalog#

DMTrO

Pricing

Purity: 98% +DMTr-O-Polyethyleneglycol 2000 Phosphoramidite

OCE
P
O
N

$80.00 / 100 μmole$150.00 / 250 mg$225.00 / 500 mg$450.00 / 1 g

Purity: 98% +Purity: 98% +(Spacer 18)

O

Pricing

Pricing

Pricing$40.00 /100μmole$150.00 / 250 mg$250.00 / 500 mg$400.00 / 1 g$ 40.00 / 100 μmole$ 50.00 / 250 mg$110.00 / 1 g

Purity: 98% +Purity: 98% +Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products
Phosphoramidites
Phosphoramidites
and Supports
and Supports
for Introducing
for Introducing
Chromophores
Chromophores& Ligands& Ligands

Ancillary Reagents

Spacer Modifier
DMTr-O-Pentyl-5-Phosphoramidite(C5 Spacer)

Catalog#
CLP-9901

PricingP$75.00 / 100 μmole$150.00 / 250 mg$220.00 / 500 mg$370.00 / 1 g

ON

C35H47N2O5P
Mol. Wt.: 606.73

Modified DNA

DMTrO

OCE

Purity: 98% +DNA Purification

Thiol Modifiers & Supports
5’-Thiol-C6-disulfide Modifier Phosphoramidite

5’-Thiol (S-Trityl)-hexyl-C6-Modifier Phosphoramidite
Catalog#Catalog#

CLP-8506

DMTrO

OCE
P
O
N

S
S

$126.00 / 100 μmole$360.00 / 250 mg$615.00 / 500 mg$1100.00 / 1 g

C42H61N2O5PS2
Mol. Wt.: 769.05

OCE
P
O
N

S
Tr

C34H45N2O2PS
Mol. Wt.: 576.87

Purity: 98% +Standard RNA

CLP-5888

Pricing

Pricing$60.00 / 100 μmole$230.00 / 250 mg$390.00 / 500 mg$660.00 / 1 g

Purity: 98% +Modified RNA

5’-Thiol Modifier-C-6 (catalog# CLP-5888): Several methods are available to introduce a thiol group at the 5’-end of an oligonucleotide. (a) Connolly, B. A.; Rider, P. Nucl.
Acids Res. 1985 ,12, 4485; Sinha, N. D.; Cook, R. M. Nucl. Acids Res. 1988, 16, 2659; Sharma, S.; Gupta, K. C. Nucl. Acids Res. 1989, 14, 4404; (b) Kumar, A.; Advani, S.;
Dawar, H.; Talwar, G. P. Nucl. Acids Res. 1991, 19, 4561).

DMTr-C6-Disulfide Solid Support (N-9987)

RNA Purification

O
S
DMTrO

O
S

lcaa-CPGOCatalog #N-9987-05
N-9987-10

Product Name
3’-Thiol ModifierC6-disulfide lcaa CPG

Bulk CPG

Pore Size
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$70

$530

$68

$110

$136

$220

For Puromycin Labelling: See N-1971-05/10; page # 74

Antisense3’-Thiol Succinyl lcaa Supports & Columns

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

126

Oligo Synthesis Products
Phosphoramidites and Supports for Introducing Chromophores & Ligands
Thiol Modifiers & Supports
1-Thiobenzoyl-hexyl-6-Phosphoramidite

5’-Thiol-modifier (C3-disulfide Phosphoramidite)*
Catalog#Catalog#

CLP-8409

CLP-9773
O

DMTrO

O

S
S

N
P
OCE

C36H49N2O5PS2
Mol. Wt.: 684.89

PricingO
Ph

S$120.00 / 100 μmole$365.00 / 250 mg$584.00 / 500 mg$936.00 / 1 g

Pricing

N
P
OCE$66.00 / 100 μmole$290.00 / 250 mg$460.00 / 500 mg$735.00 / 1 g

C22H35N2O3PS
Mol. Wt.: 438.21

Purity: 98% +Purity: 98% +Cyclic Dithiolane Disulfide Phosphoramidite**5’-S-Trityl-2’-deoxycytidine Phosphoramidite
NHAc
N
O

CLP-8407

CLP-8509
N

S
O
O
P

Catalog#Catalog#

OCE

N

C39H46N5O5PS
Mol. Wt.: 727.85

3’-Thiol modifier (S-trityl) Icaa CPG

Pricing

Pricing$150.00 / 100 μmole$380.00 / 250 mg$650.00 / 500 mg$1100.00 / 1 g$155.00 / 100 μmole$425.00 / 250 mg$680.00 / 500 mg$1090.00 / 1 g

Purity: 98% +Purity: 98% +Cyclic Dithiolane Disulfide Icaa CPG**

3’-Thiol modifier-C3-disulfide Icaa CPG*

O

Tr

O

lcaa-CPGO

DMTrO

N-9976-05/10

3’-Thiol Modifier(S-trityl) lcaa CPG
3’-Thiol ModifierC3-disulfide lcaa CPG
Cyclic Dithiolane
Disulfide lcaa CPG

500Å
1000Å
500Å
1000Å
500Å
1000Å

O

N-8408-05/10

3’-Thiol Succinyl lcaa Supports & Columns
Pore Sizelcaa-CPGN
H

S S

Product NameOOO

N-9978-05/10

N-9978-05
N-9978-10
N-9976-05
N-9976-10
N-8408-05
N-8408-10Olcaa CPGSODMTr

Catalog #

ODMTr

O

S

O

S

Bulk CPG

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$70

$530

$68

$110

$136

$220

$70

$530

$68

$110

$136

$220

$70

$530

$68

$110

$136

$220

*Srivasatava, S. C., Kumar, T. S. et al. ‘’Synthesis of high purity DMT-C3-disulfide phosphoramidite’’ Patent Application No. PCT/US2012/000103.
**Srivastava, S. C., Kumar, T. S. et al. ‘’Dithiolane based thiol modifier for labeling and stronger immobilization of bio-molecules on solid surfaces’’ The Serial
No. for the provisional application is 61/795851.

127

Toll Free: (800) 762-9323
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Standard DNA

Phosphoramidites and Supports for Introducing Chromophores & Ligands
Biotin Labelling

Biotin-dT Phosphoramidite

TM

Catalog#
O
HN
O H

O

O
HN

N
H

6 N

O
O
P
OCE

C69H89N8O12PS
Mol. Wt.: 1285.53

DMTrO

O

O
O

O

HN
H

Catalog#

Pricing

CLP-1517$104.00 / 50 μmole$185.00 / 100 μmole$400.00 / 250 mg$720.00 / 500 mg$1225.00 / 1 g

O
N
H

O

O

3

N
H

4

HN
O H

CLP-1518
Purity: 98% +$ 70.00 / 50 μmole$150.00 / 100 μmole

DMTrO$270.00 / 250 mg$485.00 / 500 mg$870.00 / 1g

O

TM

Biotin (BB) CPG

O

N-9162-05, N-9162-10TMlcaa-CPG

Pore Size

O O
HN N
H
H
S

lcaa-CPG
H
N

O
4

O

TM

Biotin (BB) CPG

N-1506-05, N-1506-10

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$115

$970

$100

$180

$200
$360
				

$115

$970

$100

$180

$200

$360

		

RNA Purification

500Å
1000Å
2000Å
500Å
1000Å

O

Modified RNA“Biotin BB” contains a tert-butyl-benzoyl group at one of the secondary amino groups of Biotin. This novel
feature is what makes ChemGenes “Biotin BB” (Catalog# CLP-1517) superior to other commercially availableObiotin products, such as “Biotin dT” and “Biotin TEG”. Another biotin product, “Biotin Phosphoramidite” canpotentially cause side reactions during oligo synthesis due to the presence of the free urea moiety of the biotin.
O
As repeated synthesis cycles are performed, this side reaction will occur when 3’-end attachment is desired
DMTrO
using a solid support. The “Biotin Phosphoramidite” has an additional problem of low solubility. “MMTr-Biotin
Phosphoramidite”, another biotin analog has a MMTr-group on the urea portion of the biotin. The MMTr-group,
however, is potentially susceptible to hydrolysis during oligo synthesis. Furthermore, the MMTr-group does
not deactivate the urea moiety of biotin towards side reactions during oligo synthesis. This novel feature wasoriginally developed by Brian Sproat and coworkers (Uwe Pieles, Brian Sproat and Gabor M. Lamm, Nucl. Acids
Res. 1990, 18,4355). This study demonstrated that the protection of the urea nitrogen causes dramatic effect in
the purity of the synthesized oligos. ChemGenes’ “Biotin BB”, which has a 7 atom spacer utilizes this protection
feature and has tert-butyl-benzoyl protection on the urea nitrogen. This product is a simple and cost effective
alternative to Biotin dT. ChemGenes also produces “Biotin BB” attached to solid support.
Bulk CPG
pack of 4 cols.

Biotin TEG
lcaa CPG

4

H

O

Biotin (BB) Phosphoramidites

D-(+) Biotinlcaa CPG

H
S

3 N

O

N

Standard RNA

Pricing

Product NameOSCatalog#N-9162-05
N-9162-10
N-9162-20
N-1506-05
N-1506-10

4OCE

C63H88N5O12PS
Mol. Wt.: 1170.44

Catalog #N
HDNA Purification

O

HS

Purity: 98% +

N

O

O
P

N

C57H76N5O9PS
Mol. Wt.: 1038.28

Purity: 98% +

P

DMTrO

3

O

N

Biotin (BB) -TEG Phosphoramidite

CEOO

Modified DNA$160.00 / 50 μmole$310.00 / 100 μmole$660.00 / 250 mg$1080.00 / 500 mg$1940.00 / 1 g

DMTrO

N

HN
O H

Pricing

H
S

4

H

CLP-1502

N

N

O

O

O

Ancillary Reagents

Biotin (BB) Phosphoramidite

Biotinylation in the sequence and at the 5’ Terminus

tivation by moisture in the diluent acetonitrile.

Antisense

For use in automated synthesis and associated rapid purification techniques. Applications to which our biotin phosphoramidites have been applied include:
1. Diagnostic probe development including occasions where multiple biotin molecules may be introduced into a probe to enhance sensitivity of ultimate detection.
2. Introduction of biotin in the sequence and at the 5’-terminus of a primer prior to PCR amplification and trapping of the derived biotinylated DNA using streptavidin magnetic beads.
3. Introduction of biotin at the 3’-terminus of a probe capable of blocking chain extension in a PCR experiment. This is acheived through Biotin-CPG (see page 30).
Protection of the N-1 position of biotin with a lipophilic group induces higher solubility. It should be noted that we have found these products to be highly susceptible to deac-

3’-End Labeling with Biotin BB CPG Solid Supports“Biotin BB” CPG is used for synthesis of 3’-Biotin oligomers. The tert-butyl-benzoyl protection prevents biotin chromophore unwanted side reactions. Also available fromChemGenes are the corresponding prepacked “Biotin BB” CPG columns listed above.
Biotin BB is a trademark of ChemGenes Corporation. The starting biotin for all biotin derivatives is Biotin-D(+).

www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands128

Oligo Synthesis Products
Phosphoramidites and Supports for Introducing Chromophores & Ligands
Branching Phosphoramidites & Supports
Symmetrical-branching Phosphoramidite

Asymmetrical-branching Phosphoramidite

Catalog#Catalog#

CLP-5215
DMTrO

N

DMTrO

Pricing

ODMTr

OCE

C54H61N2O8P
Mol. Wt.: 897.0

NN-7170-05/10

Pricing$110.00 / 100 μmole$315.00 / 250 mg$505.00 / 500 mg$810.00 / 1 g

OCE

C38H49N2O8P
Mol. Wt.: 692.7

Purity: 98% +Asymmetrical-branching Support

CLP-7169

O-Lev
O
P

$90.00 / 100 μmole$225.00 / 250 mg$405.00 / 500 mg$730.00 / 1 g

OPPurity: 98% +Symmetrical-branching Support
N-5216-05/10

O

NPPOC-DMTr Asymmetrical-branching
Phosphoramidite
Catalog#O

Lev-O

lcaa-CPG

DMTrO

CLP-7178lcaa-CPG

O

O

DMTrO

O

DMTrO

PricingN
P

OO

Symmetrical Branching Polymeric Support

OCE

O
NPPOC

N-7173-05

ODMTr
C43H52N3O1OP
Mol. Wt.: 801.

O
DMTrO

Polystyren$130.00 / 100 μmole$360.00 / 250 mg$640.00 / 500 mg$1150.00 / 1 g

Purity: 98% +

O
DMTrO

O
Bulk CPG

Catalog #N-5216-05
N-5216-10
N-7170-05
N-7170-10
N-7173-05

Product Name
Symmetrical-branchinglcaa CPG
Asymmetrical-branchinglcaa CPG
Symmetrical-branching
Polymeric Support

Pore Size
500Å
1000Å
500Å
1000Å
500Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$115

$970

$110

$170

$220

$340

$115

$970

$110

$170

$220

$340

$115

$970

$110

$170

$220

$340

Branching phosphoramidites and solid supports:

The branching phosphoramidites incorporate branching sites into an olilgonucucleotide via automated DNA synthesis directly. Branched oligonucleotides are synthesized from the incorporated glycerol backbone, which posesses two protected hydroxyl groups for chain elongation. For example, branched oligonucleotides have beenused effectively for signal amplification by introducing networks of labels or probing sites (Horn et. al. 1989; Chang et. al. 1991; Foldesi et. al. 1991).

Symmetric branching phosphoramidites:

This reagent allows simultaneous extension from the glycerol branch point because both hydroxyl groups are protected by DMTr groups and are thus removed at thesame time, resulting in two identical branches. Several cycles of incorporation of this amidite will result in a tree-like structure of 2 branched oligonucleotide arms.
Since reporter molecules, such as biotin or flourescein, can be attached to each arm, this exponential branching can amplify and thus improve the sensitivity of thesereporter molecules.

Asymmetric branching phosphoramidites:

This reagent uses DMTr to protect one hydroxyl of the glyceryl backbone and a levulinyl group to protect the other. The DMTr group is removed during the normal
deblock step and routine chain elongation can continue from this branch. Subsequent removal of the levulinyl protecting group with hydrazine permits the elongationfrom the other, resulting in asymmetrical branching. The branches can differ in sequence, reporter molecules, or both.

Levulinyl Deprotection Solution
Catalog#

Pricing

CLP-7171$44.00 / 5 ml
$72.00 / 10 ml

129

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
5’-Carboxyl Group Generating Reagent

C5 Carboxyl Introducing Phosphoramidite(Thymidine-succinyl-hexamide CEP)(‘5-O-DMT-C5-Methylacrylate-2’-deoxyuridine CEP)

Catalog#O
Catalog#OO

CLP-2244

NH
O

O

N

DMTrO

PricingO

Modified DNA

Pricing

DMTrO

CLP-2842

HN
O

N

Ancillary Reagents

Carboxyl Generating reagents

O
O

H
N

O

O

$85.00 / 100 μmole$200.00 / 250 mg$360.00 / 500 mg$645.00 / 1 g

OCE
P
N

O
C50H66N5O11P
Mol. Wt.: 944.06$85.00 / 100 μmole$230.00 / 250 mg$410.00 / 500 mg$735.00 / 1 g

O
P
N

OCE

C43H51N4O10P
Mol. Wt.: 814.86

Purity: 98% +Purity: 98% +DNA Purification

For oligos requiring a 5’-carboxylic group, this is an excellent reagent. Thisligand is introduced to the oligo via attachment to a C-6 spacer at the 5’-endof the DNA or RNA oligo.

Undecanoic acid Phosphoramidite

O

Hexyl-(C6)-amido (p-benzaldehyde)-1-Phosphoramidite
CLP-2243
H

H
N
O

C23H36N3O4P
Mol. Wt.: 449.52

O

OCE

C21H41N2O4P
Mol. Wt.: 416.54

Catalog#

Pricing

CLP-8146$265.00 / 100 μmole$600.00 / 250 mg$960.00 / 500 mg$1550.00 / 1 g

Standard RNA

OCE
P
N
O

N
P

O

Catalog#
O

Standard DNA

Oligo Synthesis Products

Pricing$265.00 /100 μmole$600.00 / 250 mg$960.00 / 500 mg$1550.00 / 1 g

Modified RNA

Purity: 98% +Purity: 98% +(+)-a-Tocopherol-Phosphoramidite(Vitamin E Phosphoramidite)5’-Carboxyl Group Generating Reagent
Several carboxyl group generating reagents are available fromChemGenes Corporation. Primarily the carboxy modified oligonucleotides can be used for immobilization to various amino modified surfaces or further oligonucleotide labeling with corresponding reportermolecules having primary alkyamino group.

CLP-2706
O

Pricing
O

O
O
ODMTr
O
P
OCE

C68H103N2O10P
Mol. Wt.: 1139.53

Purity: 98% +Hexyl-(C6)-amido (p-benzaldehyde)-1-Phosphoramidite
Aldehyde and ketone modified oligonucleotides can be used forimmobilization to various hydrazide or aminooxy modified surfaces orfurther oligonucleotide labeling with corresponding reporter molecules
having hydrazide or aminooxy group.1,2
1.Dey, S.; Sheppard, T. L. Org. Lett. 2001, 3, 3983.
2.Defrancq, E.; Lhomme, J. Bioorg. Med. Chem. Lett. 2001, 11, 931.

www.chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

130

AntisenseN$150.00 / 50 μmole$275.00 / 100 μmole$550.00 / 250 mg$990.00 / 500 mg$1780.00 / 1 g

RNA Purification

Catalog#OOligo Synthesis Products
Phosphoramidites
Phosphoramidites andand Supports
Supports forfor Introducing
Introducing Chromophores
Chromophores && Ligands
Ligands
Cholesterol Labelling
Cholesterol TEG (Tetra Ethylene Glycol) H-Phosphonate

Cholesterol TEG Icaa CPG

TEG Cholesterol (Tetra Ethylene Glycol) -H- Phosphonate TEA Salt

Catalog#
CLP-2705

Pricing$140.00 / 50 μmole$265.00 / 100 μmole$720.00 / 250 mg$1150.00 / 500 mg$1840.00 / 1 g

N-9166-05

Purity: 98% +Cholesterol (Plant source) TEG Phosphoramidite

Cholesterol (8 atom spacer) Icaa CPG

Catalog#
CLP-2795

Pricing
OCE
P
N
O

H
N

O

$140.00 / 50 μmole$265.00 / 100 μmole$650.00 / 250 mg$1100.00 / 500 mg$1760.00 / 1 gO

4O
C48H86N3O8P
Mol. Wt.: 864.19

DMTrO

H
N

O

O
O

O
lcaa-CPG

O

Purity: 98% +N-9267-05

O

DMTr-Cholesterol TEG Phosphoramidite

Cholesterol TEG (Synthetic) Phosphoramidite(Generates DMTr color) (Plant source)

OCE
P
N
O

H
N

O

O

4

O
C48H86N3O8P
Mol. Wt.: 864.19

Catalog#

Pricing

CLP-2703$150.00 / 50 μmole$275.00 / 100 μmole$525.00 / 250 mg$945.00 / 500 mg$1700.00 / 1 g

Purity: 98%+

Catalog#
CLP-2704

Purity: 98%+

Cholesterol Supports & Columns
Catalog #N-9166-05
N-9267-05

Product Name
3’-Cholesterol-TEGlcaa CPG
Cholesterol-C4lcaa CPG

Bulk CPG

Pore Sizepack of 4 cols.

Pricing$140.00 / 50 μmole$265.00 / 100 μmole$650.00 / 250 mg$1100.00 / 500 mg$1760.00 / 1 gpack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

500Å

$115

$970

$110

$175

$220

$350

500Å

$115

$970

$110

$175

$220

$350

Cholesterol TEG phosphoramidite and solid supports:

Potential therapeutic oligonucleotides must permeate the cell membrane for optimal activity. The addition of lipophilic groups to an oligonucleotide would be expected toenhance activity. The use of cholesteryl oligos and the consequent improvement in activity has been described. Cholesterol phosphoramidite is designed with branchedtetraethyleneglycol (TEG) spacer for maximium solubility in acetonitrile as well as for applications requiring multiple labels.

131

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Oligo Synthesis Products
Phosphoramidites
and Supports
for Introducing
Chromophores& Ligands
Phosphoramidites
and Supports
for Introducing
Chromophores& Ligands
Dabcyl CEP

Ancillary Reagents

Dabcyl Labelling
Thymidine-C5-dabcyl CEP
O

O

N

HN
O
N N

DMTrO
O

N
H

6

N
H

N

N N

DMTrO

OCE
P
O
N

O
N

O

O
P

C51H63N6O7P
Mol. Wt.: 903.06

Catalog#N

Pricing

CLP-9906$110.00 / 50 μmole$265.00 /100 μmole$600.00 / 250 mg$960.00 / 500 mg$1550.00 / 1 g

Purity: 98%+

$165.00 / 50 μmole$300.00 /100 μmole$580.00 / 250 mg$1040.00 / 500 mg$1870.00 / 1 g

DNA Purification

Purity: 98%+

OCE

Catalog#

Pricing

CLP-1522

C63H76N9O10P
Mol. Wt.: 1150.31

Modified DNA

HNO

Dabcyl phosphoramidites and solid supports:

Dabcyl Supports & Columns
Catalog #Product Name
Dabcyl-lcaa-CPG

500Å
1000Å
500Å

Dabcyl-succinylPolymeric Support

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$110

$940

$110

$175

$220

$350			

$110

$940

$110

$175

$220

$350			

Modified RNA

N-9756-05
N-9756-10
N-9756-PF

Bulk CPG

Pore Size

DNP Labelling
DNP-TEG CEPCAS No. 1027512-01-1

Catalog#
O

O
O

O2N

Naphthyl Red (D-Threoninol linker) phosphoramidite

NO2

O
O

N
P
OCE

CLP-9907

Pricing

C53H61N6O6P
Mol. Wt.: 909.06

Purity: 98% +DNP-TEG-lcaa-CPG

Bulk CPG

Pore Size
500Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$115

$960

$110

$185

$220

$370

132

www.chemgenes.com
Email: info@chemgenes.com
www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands

N-9127-05

Pricing$95.00 / 50 μmole$185.00 / 100 μmole$460.00 / 250 mg$820.00 / 500 mg$1390.00 / 1 g

OCE$150.00 / 50 μmole$280.00 /100 μmole$660.00 / 250 mg$1120.00 / 500 mg$1900.00 / 1 g

Product NameN

N P

DNP-TEG Supports & Columns
Catalog #NOAntisense

Purity: 98%+

N
NH

C48H64N5O13P
Mol. Wt.: 950.02

Catalog#

CLP-6643

O
DMTrO

DMTrO

RNA Purification

H
N

Standard RNA

A molecular beacon probe has its natural fluorescene quenched in solution unless it is hybridized to the target sequence. Consequently, the design ofa molecular beacon requires a fluorophore to be in one part of the sequence and the quencher molecule to be in another, with both molecules being
separated from the oligonucleotide by a hydrocarbon spacer. The Dabcyl group has been found to be a universal quencher. Dabcyl CPGs and Dabcyl
amidites are used to prepare probes with the quencher blocking the 3’-terminus.
5’-Dabcyl phosphoramidite locates the quencher at the 5’-terminus and Dabcyl-dT places it within the sequence, leaving the 3’-terminus available forpolymerase extension.

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
Fluorescein Labelling
Etheno-deoxy-adenosine CEP

Etheno-deoxy-cytidine CEPCatalog#Catalog#
N

N
N
N

N

CLP-9182

N
O

N

N

Pricing

DMTrO
O
O
P
N

CLP-9181

OCE

C42H48N7O6P
Mol. Wt.: 777.85

Pricing

DMTrO
O$95.00 / 100 μmole$240.00 / 250 mg$400.00 / 500 mg$680.00 / 1 g$95.00 / 100 μmole$240.00 / 250 mg$400.00 / 500 mg$680.00 / 1 g

O
N

P

OCE

C41H48N5O7P
Mol. Wt.: 753.8

Purity: 98% +Purity: 98% +Etheno-cytidine CEP

Etheno-adenosine CEP(Etheno-2’-O-TBDMS-cytidine CEP)

(Etheno-2’-O-TBDMS-adenosine CEP)

Catalog#NN

CLP-9191

NO

N

O-TBDMS
OCE

C48H62N7O7PSi
Mol. Wt.: 908.11

CLP-9192

N

N

DMTrO

O
P

Catalog#
N

N

Pricing

O

Pricing

N

DMTrO$190.00 / 100 μmole$470.00 / 250 mg$846.00 / 500 mg$1500.00 / 1 g$190.00 / 100 μmole$470.00 / 250 mg$846.00 / 500 mg$1500.00 / 1 g

O
O
P
N

Purity: 98% +O-TBDMS
OCE

Purity: 98% +C47H62N5O8PSi
Mol. Wt.: 884.08

Etheno Adenosine & Etheno Cytidine

Etheno-Nucleosides have high fluorescent intensity, especially etheno cytidine. They have been used for various applications such as: extremely low detection probes,
selective introduction in synthetic DNA/RNA, and nucleic acid structure function & determination. Primers with etheno modification undergo PCR and are amplified.
These fluorescent nucleosides are base sensitive and should be deprotected using mild conditions. (Srivastava, S. C.; Raza, S. K.; Misra, R. Nucl. Acids Res. 1994,
22, 1296-1304)
Etheno Adenosine; Detection Limit:10-9, Excitation : 260nm, Emission : 430nm
Etheno Cytidine; Detection Limit:10-7

Etheno Succinyl lcaa Supports & Columns
Catalog #N-9113-05
N-9113-10
N-9114-05
N-9114-10
N-9191-05
N-9191-10
N-9192-05
N-9192-10
N-9091-05
N-9091-10
N-9092-05
N-9092-10

Product Name
Etheno-deoxy-adenosine3’-lcaa CPG
Etheno-deoxy-cytidine3’-lcaa CPG
Etheno-adenosine2’-TBDMS 3’-lcaa CPG
Etheno-cytidine2’-TBDMS 3’-lcaa CPG
Etheno-adenosine2’/3’-lcaa CPG
Etheno-cytidine2’/3’-lcaa CPG

Bulk CPG

Pore Size
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$70

$550

$80

$110

$160

$240

$60

$500

$50

$95

$100

$190

$110

$910

$100

$135

$200

$270

$110

$910

$100

$135

$200

$270

$110

$910

$100

$135

$200

$270

$110

$910

$100

$135

$200

$270

133

Toll Free:(800) 762-9323
Toll Free: (800)762-9323

33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
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Phosphoramidites and Supports for Introducing Chromophores & Ligands
Hexachloro-fluorescein (HEX) Phosphoramidite

Catalog#O

OO

Pricing

O
Cl

Cl

O
Cl

N
P

O
C46H54Cl4N3O10P
Mol. Wt.: 981.72

OCE

O

O

CLP-1526

O
Cl

Cl

O
Cl

O
Cl

O
OCE
C46H52Cl6N3O10P
Mol. Wt.: 1050.61

ODMTr
O
P

Cl
O

Cl
O

CAS No. 1360547-55-2

Catalog#O

OO

CLP-1527

Cl

O
O

O
Cl
HN
ODMTr
O
P
N

C69H74Cl4N3O13P
Mol. Wt.: 1326.12

Purity: 98% +Hexachloro-fluorescein-cyclohexyl CEP

Purity: 98% +OCE$175.00 / 50 μmole$350.00 / 100 μmole$850.00 / 250 mg$1550.00 / 500 mg

Pricing$148.00 / 50 μmole$292.00 / 100 μmole$540.00 / 250 mg$1050.00 / 500 mg

Purity: 98% +OCE

Modified RNA

C69H72Cl6N3O13P
Mol. Wt.: 1395.01

CAS No. 204697-37-0OOOStandard RNA$148.00 / 50 μmole$292.00 / 100 μmole$540.00 / 250 mg$1050.00 / 500 mg

HN

N
P

HN

Pricing

Cl

O

O

Cl

O

6-FAM Phosphoramidite

O

Cl

O

N

Cl

Cl

Catalog#

O

PricingO
Cl

DNA Purification

O

CLP-9778

O

O

Purity: 98% +Tetrachloro-fluorescein-cyclohexyl CEP

Catalog#ClO

Modified DNA

O
HN

O

$175.00 / 50 μmole$350.00 / 100 μmole$850.00 / 250 mg$1550.00 / 500 mg

O
Cl

Cl

CLP-9779

O

Ancillary Reagents

Fluorescein Labelling
Tetrachloro-fluorescein (TET)Phosphoramidite

Standard DNA

Oligo Synthesis ProductsOOO
RNA Purification

O
N
P

HN

O
OCE
C46H58N3O10P
Mol. Wt.: 843.94

Catalog#
CLP-9777

Purity: 98% +$98.00 / 50 μmole$184.00 / 100 μmole$490.00 / 250 mg$880.00 / 500 mg

These fluorescein derivatives have been used for non-isotopic fluorescent sequencing, hybridization, and PCR product quantitation. They

Antisense

TET, HEX, 6-FAM

Pricingeither are used for antibody binding or as a fluorophore for fluorescent signal generation. Each have their own excitation and emission wavelengths: 6-FAM (ABS=492nm & EM=515nm), HEX (ABS=535nm & EM=556 nm), TET (ABS=521nm & EM=536nm). The fluorescence andabsorbance of fluorescein is very pH sensitive with both being the greatest at pH 8-9.
These fluorescent labels are generally added to the 5’ end. Purification of the oligo is recommended either by HPLC or PAGE.

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Chromophores &Ligands134

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
Fluorescein Labelling
5-Fluorescein CEP

Fluorescein-dT CEP

O
O
O

O

O

O

O

O
HN

O

6N

O

H
N

O

O

DMTrO
O
C79H89N6O17P
Mol. Wt.: 1425.56

OP
N

Catalog#

OCE

Pricing

CLP-4282

Catalog#$155.00 / 50 μmole$275.00 / 100 μmole$550.00 / 250 mg$990.00 / 500 mg

CLP-9905

Purity: 98% +N-5122-05
N-9979-05
N-9986-05

Product Name
Fluorescein-dT-Icaa CPG
Fluorescein-Icaa CPG
6-FAM-lcaa CPG (DMT)$180.00 / 50 μmole$325.00 / 100 μmole$560.00 / 250 mg$1100.00 / 500 mg

Purity: 98% +Supports & Columns
Catalog #Pricing

Bulk CPG

Pore Size
500Å
500Å
500Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$120
$110
$110

$995
$970
$970

$120
$110
$110

$200
$180
$180

$240
$220
$220

$400
$360
$360

CLP-4282, CLP-9905 fluorescein amidites generate DMTr-color after oligo coupling.

135

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Phosphoramidites
Supports
for Introducing
Chromophores& Ligands
Phosphoramidites
and and
Supports
for Introducing
Chromophores& Ligands

Standard DNA

Oligo Synthesis Products
Fluorescein Labelling
DMTr-5-FAM Phosphoramidite
Catalog#Catalog#OO

CLP-9780

O

O

O

O

O
N
P
O

OCE

O

$160.00 / 50 μmole$300.00 / 100 μmole$610.00 / 250 mg$1090.00 / 500 mg

O$160.00 / 50 μmole$300.00 / 100 μmole$610.00 / 250 mg$1090.00 / 500 mg

N
P

NH
O

OCE

ODMTr
C68H78N3O13P
Mol. Wt.: 1176.33

Purity: 98% +ODMTr

PricingO

Modified DNA

O

HN

O

PricingO

CLP-9789

O

O

O

Ancillary Reagents

DMTr-6-FAM Phosphoramidite

Purity: 98% +6-FAM CPG

DNA Purification

C68H78N3O13P
Mol. Wt.: 1176.33

5-FAM CPGOStandard RNA

O

O
O

O

O

O

O
O

O

O
O

O

O

O
O
O

O

Modified RNA

O

lcaa CPG

HN

lcaa CPG

NH
O

O
ODMTr

O
ODMTr

Catalog# N-9985-05

Catalog# N-9969-05

Catalog #Product Name

Pore Size

Bulk CPG

pack of 4 cols.

RNA Purification

5 & 6 FAM Supports & Columns

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

N-9985-05

DMT-6-FAM lcaa CPG

500Å

$110

$970

$110

$180

$220

$360

N-9969-05

DMT-5-FAM lcaa CPG

500Å

$104

$832

$104

$168

$208

$375

ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

Please Indicate Synthesizer when Ordering
Akta OligopilotAKwww.chemgenes.com
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www.chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands136

Rodamine (Tamra) LabellingN4-6-TAMRA-cytidine-3’- lcaa CPG

5’-TAMRA CEP
N

N

O

N

O

O

N
H
N

O
HN

O

O

O

O
O

N

O

O
O

N

N

DMTrO
O
O

O

OCE
P
N

lcaa-CPGOOCatalog# N-2145-05

C39H48N5O6P
Mol. Wt.: 713.80

Catalog#

Pricing

CLP-9066

Cocktail for TAMRA
Catalog#

Pricing

RN-8561$50.00 / 5 ml

$185.00 / 50 μmole$395.00 / 100 μmole$1090.00 / 250 mg$1740.00 / 500 mg

Purity: 98% +Rox Supports & Columns

6-TAMRA Supports & Columns
N

N

N+

O

N+

O

O
ODMTr

O

O
O

H
N

H
N

O
O

ODMTr

O

O

O
O

O
lcaa-CPGO

lcaa-CPGOCatalog# N-2255-05

Catalog# N-2246-05

TAMRA Supports & Columns
Catalog #Product Name

Bulk CPG

Pore Sizepack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

500Å

$104

$832

$104

$168

$208

$375

N-2246-05

N4-6-TAMRA-Cytidine3’-lcaa CPG
Rox-lcaa CPG

500Å

$120

$880

$120

$220

$224

$392

N-2255-05

TAMRA-lcaa CPG

500Å

$104

$832

$104

$168

$208

$375

N-2145-05

TAMRA & Rox

Like Fluorescein, Tetra-methyl Rhodamine (TAMRA) conjugates are usually a mix of two isomers. ChemGenes supplies 5’-TAMRA as amidites withboth two isomers having the same spectral properties. They both excite at λ 540 nm and emit at λ 570 nm. They are much less pH sensitive. We
offer the CPG columns for the 3’-TAMRA labeling and also TAMRA NHS Esters for labeling amino-modified oligonucleotides.
These fluorescent labels are generally added to the 5’ end. Purification of the oligo is recommended either by HPLC or PAGE.
Note: Price includes TAMRA Cocktail

137

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Standard DNA

Phosphoramidites
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands

Standard DNA

Oligo Synthesis Products
Phosphoramiditesand
andSupports
Supportsfor
forIntroducing
IntroducingChromophores
Chromophores&&Ligands
Ligands
Phosphoramidites

Ancillary Reagents

Psoralen LabellingPsoralen CEP

Psoralen-C2 spacer CEP(Generates DMTr color)

N

N
P O

P O

CEO

CEO
O
ODMTr

O

O

O

O

CLP-6644

Pricing

Catalog#$190.00 / 100 μmole$660.00 / 250 mg$1056.00 / 500 mg

Purity: 98% +Psoralen-C4 spacer CEP

CAS No. 126221-83-8

Psoralen- C6 spacer CEPStandard RNA

O
P
OCE

Pricing

CLP-6647

DNA Purification$115.00 / 50 μmole$185.00 / 100 μmole$495.00 / 250 mg$890.00 / 500 mg

Purity: 98% +N

O

C26H35N2O6P
Mol. Wt.: 502.5

C48H55N2O9P
Mol. Wt.: 834.93

Catalog#O

Modified DNA

O

O
N

O

O

O

O
P
OCE

O

O

C28H39N2O6P
Mol. Wt.: 530.59

OO

C30H43N2O6P
Mol. Wt.: 558.65

CLP-6648

Pricing

Catalog#
CLP-6641

Purity: 98% +Pricing$170.00 / 100 μmole$645.00 / 250 mg$1030.00 / 500 mg

RNA Purification$195.00 / 100 μmole$630.00 / 250 mg$1010.00 / 500 mg

Modified RNA

Catalog#

CAS No. 518046-08-7

Purity: 98% +Please Indicate Synthesizer when Ordering
ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Antisense

ABI

Akta OligopilotAKwww.chemgenes.com
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Email: info@chemgenes.com
Email: info@chemgenes.com

Chromophores &Ligands138

Nucleosides
Oligo
Synthesis& Reagents
Products
Phosphoramidites and Supports for Introducing Chromophores & Ligands
Psoralen LabellingPsoralen-hexaethyleneglycol-CEP

Psoralen CPG(18 atom spacer)OO

CPG-lcaa
N

O
O
5

P O
CEO

O

O

O

O
ODMTr

O

C36H55N2O11P
Mol. Wt.: 722.80

Catalog#OOO

N-9375-05

Pricing

CLP-6642$187.00 / 100 μmole$570.00 / 250 mg$1037.00 / 500 mg

Purity: 98% +Psoralen Supports & Columns
Catalog #N-9375-05
N-9081-05
N-9081-10

Product Name
Psoralen CPG
Psoralen-C4
lcaa CPG

Bulk CPG

Pore Size
500Å
500Å
1000Å

pack of 4 cols.

pack of 10 cols.

100

1

0.2

1.0

0.2

1.0

mg

g

µmole

µmole

µmole

µmole

$115
$140

$970
$970

$110
$110

$170
$170

$220
$220

$340
$340

Psoralens are a class of naturally occuring compounds which have been used for centuries to treat skin and tumor diseases. Psoralen binds to DNA non-specifically. Psoralen
modified oligonucleotides are expected to be superior than Psoralen itself as they will hydrolize to target oligonucleotides having complementary sequences. Psoralen derived
oligonucleotides have been synthesized and found to recognize complementary target DNA sequences. The double stranded DNA fragents were found to be covalently crosslinked upon irradiation at 35 nm. (Pieles, U.; English, U. Nucl. Acids Res. 1989, 17, 285; Pieles, U.; Sproat, B. S.; Neuner, P.; Cramer, F. Nucl. Acids. Res. 1989, 17, 8967).
Psoralen attached oligonucleotides have also been hybridized with complementary target sites on RNA followed by cross-linking after photo reaction. (Teare, J.; Wollenzien,
P. Nucl. Acids Res. 1989, 17, 3559). Photoinduced cross-linking has also been achieved on a double-stranded DNA by forming a triple helix. (Takasugi, M.; Guendouz, A.;
Chassignol, M.; Decont, J. L.; Lhomme, J.; Thuoing, N. T., Helene, C. Proc. Natl. Acad. Sci. USA, 1991, 88, 5602). Furthermore, Psoralen derived oligonucleotide methylphosphates have been shown to cross-link in a sequence specific manner to single-dependant antiviral activity in cultured cells infected with herpes simplex virus type-1(HSV-1) (Kulka, M.; Smith, C.; Aurelian, L.; Fisheluich, R.; Meade, K.; Miller, P.; Ts’O, P.O.P. Proc. Natl. Acad. Sci. USA, 1989, 86, 6868).
The psoralen support is a 16 atom spacer between Psoralen and the oligo chain (3’-end).

Please Indicate Synthesizer when Ordering
ABI

ABI 3900

Expedite

MerMadePolyPlex

AB30

AB39

EX

MR

PX

Akta Oligopilot
AK

139

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33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected
Nucleosides

Phosphoramidites and Supports for Introducing Chromophores& Ligands
Unprotected Nucleosides

B
HOO

Catalog#

CAS No.

AC
GTC

DN-1001
DN-1002
DN-1003
DN-1004
DN-1002fb

958-09-8
3992-42-5
312693-72-4
50-89-5

Catalog#

Product Name

1g

5g

25g

100g

500g

DN-10012’- β-D-Deoxyadenosine Monohydrate$6.00$17.00$68.00$218.00$354.00$6.00$17.00$68.00$218.00$354.00$6.00$17.00$68.00$218.00$354.00$6.00$17.00$68.00$218.00$354.00$6.00$19.00$73.00$250.00$1,000.00

DMT-protected
Nucleosides

OH

B

N-protected
Nucleosides

Deoxy Nucleosides

M.W. 269.26

DN-10022’-β-D-Deoxycytidine Monohydrochloride

DN-10032’-β-D-Deoxyguanosine Monohydrate

Reagents

M.W. 263.68

M.W. 285.26

DN-1004

β-D-Thymidine
M.W. 242.23

DN-1002fb

2’-β-D-Deoxycytidine (Free Base)

Triphosphates

M.W. 227.18

Purity: (1) All the above produced have a purity of 99% +(2) α anomer undetected

SugarsNHS Esters

140

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Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
Dideoxy Nucleosides

B
HOO
Catalog#

B

Catalog#

CAS No.

A
C
G
T
U
I

DDN-1844
DDN-1868
DDN-1882
DDN-1883
DDN-1892
DDN-1893

4097-22-7
7481-89-2

Product Name

DDN-1844
DDN-1868
DDN-1882
DDN-1883
DDN-1892

2’,3’-β-D-Dideoxyadenosine M.W. 235.24
2’,3’-β-D-Dideoxycytidine M.W. 211.22
2’,3’-β-D-Dideoxyguanosine M.W. 251.24
3’-β-D-Deoxythymidine M.W, 226.23
2’,3’-β-D-Dideoxyuridine M.W, 212.20

DDN-1893

2’,3’-β-D-Dideoxyinosine M.W, 236.23

100mg

500mg

1g

$80.00$80.00$80.00$80.00$210.00$210.00$210.00$210.00$480.00$480.00$480.00$480.00$1,680.00$1,680.00$1,680.00$1,680.00$80.00$80.00$210.00$210.00$480.00$480.00$1,680.00$1,680.00

Purity:(1) All the above produced have a purity of 98% +7-Deaza-

Catalog#3416-05-5
5983-09-5
69655-05-6(2) α anomer undetected

7-Deaza-7-Iodo-2’-3’-β-D-dideoxyguanosine
Catalog#

DDN-3818

Pricing

NH2

I$388.00 / 100 mg$740.00 / 250 mg$1650.00 / 500 mg$2800.00 / 1 g

N
N

N

HO
O

Purity: 98% +C11H13IN4O2
Mol. Wt.: 360.15

5-Iodo-2’-3’-β-D-dideoxycytidine
Catalog#

DDN-3819

O

I

Pricing

NH
N

NH2

N

HO
O
C11H13IN4O3
Mol. Wt.: 376.15

5-Iodo-2’-3’-β-D-dideoxyuridine
Catalog#

Pricing

I
N
O

N
HO
O

DDN-1884

O

PricingI$220.00 / 100 mg$440.00 / 250 mg$700.00 / 500 mg$1120.00 / 1 g

NHN$170.00 / 100 mg$340.00 / 250 mg$540.00 / 500 mg$860.00 / 1 g

O

HO
O

C9H12IN3O3
Mol. Wt.: 337. Purity: 98% +C9H11IN2O4
Mol. Wt.: 338.1

7-Deaza-2’,3’-β-D-dideoxyadenosine
Catalog#N
N

N

Catalog#HOO
C11H14N4O2
Mol. Wt.: 234.25

DDN-1863

Pricing$360.00 / 100 mg$720.00 / 250 mg$1152.00 / 500 mg$1844.00 / 1 g

Purity: 98% +Purity: 98% +CAS No. 105784-83-6

7-Deaza-2,3-β-D-dideoxygunaosine

DDN-3864NH2$388.00 / 100 mg$740.00 / 250 mg$1650.00 / 500 mg$2800.00 / 1 g

Purity: 98% +DDN-1731
NH2

5g

O

Pricing
NH

N

N

NH2

HO
O
C11H14N4O3
Mol. Wt.: 250.25$360.00 / 100 mg$720.00 / 250 mg$1152.00 / 500 mg$1844.00 / 1 g

Purity: 98% +141

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected Nucleosides
Unprotected Nucleosides

2’-β-D-Deoxyinosine

2’-β-D-Deoxyuridine
Catalog#Catalog#

DN-6373

DN-4002

PricingO$ 17.00 / 1 g$ 75.00 / 5 g$ 135.00 / 10 g
$ 320.00 / 25 g
$1,120.00 / 100 g

O

HO
O
OH
C9H12N2O5
Mol. Wt.: 228.

Pricing

O
N

NH

N

N

HO
O
OH
C10H12N4O4
Mol. Wt.: 252.23

Purity: 98% +$ 19.00 / 1 g$ 83.00 / 5 g$155.00 / 10 g
$350.00 / 25 g
$1,197.00 / 100 g

Purity: 98% +CAS No. 890-38-0

8-Oxo-2’-deoxyguanosine

5-Methyl-2’-deoxycytidine

NH2

Pricing

H3C

O
N

N

NH2

HO
O
OH
C10H13N5O5
Mol. Wt.: 283.24$ 160.00 / 250 mg$ 280.00 / 500 mg$ 500.00 / 1 g$2,215.00 / 5g

DN-2013

Pricing

N

NH

O

N
HO
O

OH
C10H15N3O4
Mol. Wt.: 241.2

Purity: 98% +Triphosphates

H
N

Catalog#

DN-1205

O

Reagents

CAS No. 951-78-0

Catalog#

DMT-protected
Nucleosides

NH
N

N-protected
Nucleosides

Modified Deoxy Nucleosides

Unprotected
Nucleosides

Nucleosides & Reagents$ 60.00 / 250 mg$110.00 / 500 mg$195.00 / 1 g$780.00 / 5g

Purity: 98% +CAS No. 838-07-3

Etheno-2’-deoxycytidine

Etheno-2’-deoxyadenosine

SugarsCAS No. 88847-89-6

Catalog#Catalog#
DN-4252

N

Pricing

N
O

HO
O
OH
C11H13N3O4
Mol. Wt.: 251.

CAS No. 68498-26-0$50.00 / 25 mg$160.00 / 100 mg$320.00 / 250 mg$510.00 / 500 mg

Purity: 98% +

N
N

N
N

HO
O
OH
C12H13N5O3Mol. Wt.: 275.26

CAS No. 68498-25-9

Pricing
NHS Esters

N

DN-4895N$50.00 / 25 mg$160.00 / 100 mg$320.00 / 250 mg$510.00 / 500 mg

Purity: 98% +142www.chemgenes.com
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Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
Modified Deoxy Nucleosides
5-Bromo-2’-deoxyuridine

8-Bromo-2’-deoxyguanosine

Catalog#Catalog#

DN-1136

O
Br
O

N

N

Pricing

NH

HO
O
OH
C9H11BrN2O5
Mol. Wt.: 307.

$20.00 / 1 g$90.00 / 5 g$160.00 / 10 g
$290.00 / 25 g

Purity: 98% +5-Bromo-2’-deoxycytidine

DN-1203

O

Pricing

NH

Br
N

N

NH2

O
OH
C10H12BrN5O4
Mol. Wt.: 346.14

Purity: 98% +CAS No. 13389-03-2

5-Iodo-2’-deoxyuridine
Catalog#Catalog#
DN-6496

NH2
N
O

N
HO
O

OH
C9H12BrN3O4
Mol. Wt.: 306

CAS No. 1022-79-3$80.00 / 1 g$320.00 / 5 g$512.00 / 10 g
$1,020.00 / 25 g

NHN

$48.00 / 1 g$192.00 / 5 g$308.00 / 10 g
$616.00 / 25 g

O

HO
O
OH
C9H11IN2O5
Mol. Wt.: 354

Purity: 98% +CAS No. 54-42-2

NH2

Catalog#N

DN-1181

I
O

HO
O
OH
C9H12IN3O4
Mol. Wt.: 353

CAS No. 611-53-0

Pricing

I

Purity: 98% +5-Iodo-2’-deoxycytidineN

DN-1180

O

PricingBr$80.00 / 1 g$320.00 / 5 g$512.00 / 10 g
$1,020.00 / 25 g

HO

8-Bromo-2’-deoxyadenosine
Catalog#
NH2
N

Pricing$50.00 / 1 g$225.00 / 5 g$385.00 / 10 g
$770.00 / 25 g

Purity: 98% +

N

Br
N

N

HO
O
OH
C10H12BrN5O3
Mol. Wt.: 330.

CAS No. 14985-44-5

DN-1182

Pricing$90.00 / 1 g$380.00 / 5 g$646.00 / 10 g
$1,290.00 / 25 g

Purity: 98% +143

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected
Nucleosides

Unprotected Nucleosides
Modified Deoxy Nucleosides
3

N -Methyl-thymidine

Catalog#

DN-1599

DN-6493

Pricing

Pricing$ 42.00 / 25 mg$135.00 / 100 mg$540.00 / 500 mg$ 110.00 / 25 mg$ 375.00 / 100 mg$1,590.00 / 500 mg

Purity: 98% +N1-Methyl-2’-deoxyadenosine

CAS No. 5040-21-1

Purity: 98% +N3-Methyl-2’-deoxyuridine

DN-1597

DN-6495

Pricing

Pricing$ 120.00 / 25 mg$ 382.00 / 100 mg$1,528.00 / 500 mg$ 80.00 / 25 mg$275.00 / 100 mg$1,100.00 / 500 mg

N1-Methyl-2’-deoxyguanosine

CAS No. 24514-32-7

Catalog#
HN

DN-1598

CH3

DN-7474

O

PricingN

PricingO
OH
C11H17N3O4
Mol. Wt.: 255.27

Purity: 98% +SugarsNHO$ 88.00 / 1 g$ 410.00 / 5 g$ 640.00 / 10 g

Purity: 98% +NHS Esters

CAS No. 5132-79-6

Purity: 98% +N4-Ethyl-2’-deoxycytidine

Catalog#$ 120.00 / 25 mg$382.00 / 100 mg$1,528.00 / 500 mg

Triphosphates

Catalog#
Reagents

Catalog#

Purity: 98% +DMT-protected
Nucleosides

Catalog#

N-protected
Nucleosides

N3-Methyl-2’-deoxycytidine

CAS No. 70465-61-1

N4-Methyl-2’-deoxycytidine

N6-Methyl-2’-deoxyadenosine

Catalog#Catalog#

DN-2016

DN-2015

Pricing

Pricing$88.00 / 1 g$410.00 / 5 g$640.00 / 10 g

$ 90.00 / 1 g$410.00 / 5 g$730.00 10 g

Purity: 98% +CAS No. 2002-35-9

Purity: 98% +144

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Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
Modified Deoxy Nucleosides
4-Thio-2’-deoxyuridine

4-Thio-thymidine

CAS No. 7236-57-9

Catalog#Catalog#

DN-1781

DN-1263

Pricing

Pricing$45.00 / 50 mg$75.00 / 100 mg$210.00 / 250 mg$45.00 / 50 mg$75.00 / 100 mg$210.00 / 250 mg

Purity: 98% +Purity: 98% +O6-(Carboxymethyl)-2’-deoxyguanosine (Calcium Salt)

6-Thio-2’-deoxyguanosine
Catalog#

Ca+2

O

DN-1269

Purity: 98% +DN-2019

O

Pricing$45.00 / 50 mg$75.00 / 100 mg$210.00 / 250 mg

Catalog#

O

N

N

N

Pricing
NH2

N

HO
O
OH
C12H14N5O6- (Free carboxyl
Mol. Wt.: 324.27

CAS No. 789-61-7

5-Propynyl-2’-deoxycytidine
Catalog#HOO
OH
C12H15N3O4
Mol. Wt. 265.27

DN-1846

NH
N

O

Catalog#O

DN-1541

N

Purity: 98% +5-Propynyl-2’-deoxyuridine

NH2N$ 80.00 / 25 mg$275.00 / 100 mg$690.00 / 250 mg

O

HOPricing$115.00 / 10 mg$225.00 / 25 mg$380.00 / 100 mg

Purity: 98% +O
OH
C12H14N2O5
Mol. Wt.: 266.2

CAS No. 84558-94-1

Pricing$ 75.00 / 10 mg$160.00 / 25 mg$300.00 / 100 mg

Purity: 98% +145

Toll Free: (800) 762-9323
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Unprotected
Nucleosides

Unprotected Nucleosides

Modified Deoxy Nucleosides

N-protected
Nucleosides

2’-Deoxy-α-Nucleosides

Product Name
α-D-2’-Deoxyadenosine M.W. 251.24
α-D-2’-Deoxycytidine M.W. 227.22
α-D-2’-Deoxyguanosine M.W. 267.24
α-D-Thymidine M.W, 242.23

100mg$80.00$80.00$80.00$80.00500mg$360.00$360.00$360.00$360.00

1g$645.00$645.00$645.00$645.00

500mg$195.00$195.00$195.00$195.00$195.00

1g$325.00$325.00$325.00$325.00$325.00

Reagents

Catalog#
DN-6351
DN-6352
DN-6353
DN-6354

Catalog#
DN-6351
DN-6352
DN-6353
DN-6354

DMT-protected
Nucleosides

B
A
C
G
T

Purity: All the above produced have a purity of 98% +

OH
O
OH

B
A
C
G
T
U

Catalog#
DN-8231
DN-8232
DN-8233
DN-8234
DN-8235

Product Name
β-L-2’-Deoxyadenosine M.W. 251.24
β-L-2’-Deoxycytidine M.W. 227.22
β-L-2’-Deoxyguanosine M.W. 267.24
β-L-Thymidine M.W, 242.23
β-L-2’-Deoxyuridine M.W, 228.20

100mg$55.00$55.00$55.00$55.00$55.00

SugarsCatalog#
DN-8231
DN-8232
DN-8233
DN-8234
DN-8235

2’-Deoxy-β-L-Nucleosides
Triphosphates

B

NHS Esters

2’-Deoxy-2-Amino-β-L-adenosine
Catalog#
DN-8331

Pricing$75.00 / 100 mg$300.00 / 500 mg$525.00 / 1 g

Purity: 98% +146

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Unprotected Nucleosides Unprotected
Unprotected
Nucleosides
Nucleosides
Modified Deoxy Nucleosides
5-Aza-2’-deoxycytidine

CAS No. 2353-33-5

2’-Deoxynebularine(4-Amino-1-(2’-deoxy-ß-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

Catalog#Catalog#

DN-1771

DN-1266

Pricing

Pricing$42.00 / 10 mg$154.00 / 50 mg$264.00 / 100 mg$45.00 / 50 mg$75.00 / 100 mg$210.00 / 250 mg

Purity: 98% +Purity: 98% +3’-Azido-3’-deoxythymidine; Azidothymidine (AZT)
Zidovudine; Retrovir

CAS No. 4546-68-3(2’-deoxypurine-riboside)

3’-O-Levulinyl-2’-deoxyguanosine

CAS No. 30516-87-1

Catalog#
DN-1774

PricingN

O
C15H19N5O6
Mol. Wt.: 365.34

Purity: 98% +Purity: 98% +2’-deoxy-isoguanosine
Catalog#

NH2
N

DN-1265$42.00 / 10 mg$154.00 / 50 mg$264.00 / 100 mg

Pricing$45.00 / 50 mg$75.00 / 100 mg$210.00 / 250 mg

OO

Catalog#

Pricing

NH2

O

Purity: 98% +CAS No. 26889-42-9

DN-1267NH
N

HO$32.00 / 100 mg$260.00 / 1 g

2’-Amino-2’-deoxycytidine

Catalog#

O
N

N

NH

DN-1268

O

PricingN

HO
O
OH
C10H13N5O4
Mol. Wt.: 267.24$45.00 / 10 mg$126.00 / 50 mg$206.00 / 100 mg

Purity: 98% +147

Toll Free: (800) 762-9323
Toll Free: (800)33 Industrial
762-9323
Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected
Nucleosides

Nucleosides & Reagents
Unprotected Nucleosides
Unprotected Nucleosides

7-Deaza-2’-deoxyadenosine; 2’-Deoxytubercidin

7-Deaza-2’-deoxyguanosine
Catalog#

DN-1143

DN-4567

Pricing

Pricing$122.00 / 100 mg$360.00 / 500 mg$640.00 / 1 g$180.00 / 100 mg$442.00 / 500 mg$818.00 / 1 g(7-Iodo-2’-Deoxytubercidin)

Purity: 98% +CAS No. 86392-75-8

7-Deaza-7-Iodo-2’-deoxyguanosine

Catalog#
I

NH2
N

N

N

O
OH
C11H13IN4O3
Mol. Wt.: 376.15

Catalog#I

DN-2561

Purity: 98% +DN-2563

NH

Pricing$75.00 / 10 mg$160.00 / 25 mg$342.00 / 100 mg

O

N

N

NH2

HO
O
OH
C11H13IN4O4
Mol. Wt.: 392.15

Pricing$75.00 / 10 mg$160.00 / 25 mg$386.00 / 100 mg

Purity: 98% +CAS No.166247-63-8

CAS No.172163-62-1

7-Deaza-2’-deoxyinosine

7-Deaza-O6-methyl-2’-deoxyguanosine

DN-1145

DN-1147

Pricing

Pricing$180.00 / 100 mg$442.00 / 500 mg$818.00 / 1 g$165.00 / 100 mg$388.00 / 500 mg$710.00 / 1 g

Purity: 98% +Purity: 98% +NHS Esters

Catalog#

SugarsCatalog#

CAS No. 97224-58-3

Triphosphates

HO

Reagents

7-Deaza-7-iodo-2’-deoxyadenosine;

DMT-protected
Nucleosides

Catalog#

Purity: 98% +CAS No. 60129-59-1

N-protected
Nucleosides

7-Deaza Deoxy Nucleosides

148

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Nucleosides
Unprotected Nucleosides

Unprotected
Nucleosides
Unprotected
Unprotected
Nucleosides
Nucleosides

Ribo Nucleosides
B
A
C
G
U
I

Catalog#
RP-1183
RP-1184
RP-1185
RP-1186
RP-1187

Catalog#
Product Name
RP-1183
Adenosine M.W. 267.25
RP-1184
Cytidine M.W. 243.22
RP-1185
Guanosine M.W. 283.24
RP-1186
Uridine M.W. 244.20
RP-1187
Inosine M.W. 268.23
Purity: All the above produced have a purity of 98% +Modified Ribo Nucleosides
5-Methyl-cytidine

CAS No.
58-61-7
65-46-3
58-96-8
58-63-9

1g
$4.00
$4.00
$4.00
$4.00
$4.00

5g
$12.00$12.00$12.00$12.00$12.00100g$96.00$96.00$96.00$96.00$96.001kg$700.00$700.00$700.00$700.00$700.00

CAS No.1463-10-1

ribothymidine

CAS No. 2140-61-6

Catalog#Catalog#

RP-1188

RP-1832

Pricing

Pricing$70.00 / 1 g$260.00 / 5 g$70.00 / 1 g$260.00 / 5 g

Purity: 98% +Purity: 98% +Ara-5-methyl-cytidine
N,N-Dimethyl-adenosine

Catalog#

CAS No. 2620-62-4
NH2

Catalog#N

RP-2017

PricingO

N

Pricing$16.00 / 25 mg$48.00 / 100 mg$250.00 / 1 g

HOO$16.00 / 25 mg$48.00 / 100 mg$250.00 / 1 g

Purity: 98% +RP-1835

H3C

OH
OH
C10H15N3O5Mol. Wt.: 257.2

Purity: 98% +Uridine-arabinose
Catalog#O

RP-2325

NH
N

O

HO
O
OH
OH
C9H12N2O6
Mol. Wt.: 244.2

Pricing$16.00 / 25 mg$48.00 / 100 mg$250.00 / 1 g

Purity: 98% +149

Toll Free: (800) 762-9323
Toll Free: (800)33 Industrial
762-9323
Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected
Nucleosides

Nucleosides & Reagents
Unprotected Nucleosides
Unprotected Nucleosides
Modified Ribo Nucleosides

N-protected
Nucleosides

2’-Deoxy-2’-Fluoro Nucleosides
Catalog#A
C
GU

RP-1220
RP-1218
RP-1219
RP-1217

Product Name
2’-Fluoro-2’-deoxyadenosine M.W. 269.23
2’-Fluoro-2’-deoxycytidine M.W. 245.21
2’-Fluoro-2’-deoxyguanosine M.W. 285.23
2’-Fluoro-2’-deoxyuridine M.W, 246.19

Catalog#

1g$88.00$88.00$88.00$76.005g$240.0$240.0$240.0$220.010g$405.00$405.00$405.00$375.00

8-Thio-guanosine
Catalog#

RP-2304

RP-1190

Pricing

Pricing$110.00 / 100 mg$220.00 / 250 mg$750.00 / 1 g

Purity: 98% +Purity: 98% +CAS No. 26001-38-7

2-Amino-purine-riboside

2,6-Diaminopurine-riboside
Catalog#RP-8335

RP-8334

Pricing

Pricing$48.00 / 1 g$225.00 / 5 g$1,010.00 / 25 g

$28.00 / 1 g$66.00 / 5 g$224.00 / 25 g

Purity: 98% +NHS Esters

CAS No. 2096-10-8

SugarsCatalog#

Purity: 98% +Triphosphates$125.00 / 100mg$280.00 / 250 mg$1000.00 / 1 g

CAS No. 13957-31-8

CAS No. 4546-54-7

Reagents

4-Thio-uridine

500mg$48.00$48.00$48.00$42.00DMT-protected
Nucleosides

Catalog#
RP-1220
RP-1218
RP-1219
RP-1217B

6-Chloro-inosine; 6-Chloropurine-riboside
Catalog#
RP-6649

Pricing$48.00 / 1 g$225.00 / 5 g$1,010.00 / 25g
CAS No. 5399-87-1

Purity: 98% +150

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Unprotected
Nucleosides
Unprotected
Unprotected
Nucleosides
Nucleosides

Modified Ribo Nucleosides
5-Bromo-uridine

5-Bromo-cytidine

CAS No. 17676-66-3

Catalog#Catalog#

RP-1215

RP-1192

Pricing

Pricing$12.00 / 100 mg$24.00 /250 mg$86.00 / 1 g$380.00 / 5g

$10.00 / 100 mg$20.00 /250 mg$64.00 / 1 g$256.00 / 5g

Purity: 98% +8-Bromo-adenosine

CAS No. 2946-39-6

Purity: 98% +8-Bromo-guanosine
Catalog#Catalog#

RP-1214

RP-1216

Pricing

Pricing$26.00 / 100 mg$58.00 /250 mg$105.00 / 1 g$426.00 / 5g

$26.00 / 100 mg$58.00 /250 mg$105.00 / 1 g$426.00 / 5g

Purity: 98% +5-Iodo-cytidine

CAS No. 1147-23-5

CAS No. 957-75-5

CAS No. 4016-63-1

5-Iodo-uridine
Catalog#Catalog#

RP-1221

RP-1089

Pricing

Pricing$43.00 / 100 mg$96.00 /250 mg$348.00 / 1 g$1,390.00 / 5g

$20.00 / 100 mg$40.00 /250 mg$120.00 / 1 g$540.00 / 5g

Purity: 98% +CAS No. 1024-99-3

Purity: 98% +151

Toll Free: (800) 762-9323
Toll Free: (800)33 Industrial762-9323
Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Nucleosides

Unprotected Nucleosides

Unprotected
Nucleosides

Unprotected
Unprotecte

Nucleosides & Reagents
Unprotected
Nucleosides
Unprotected
Nucleosides
Etheno-adenosine

CAS No. 39007-51-7

Etheno-cytidine
Catalog#Catalog#

RP-2311

RP-2310

Pricing

Pricing

Purity: 98% +Purity: 98% +Catalog#

NH2

Catalog#O

RP-1842

NH

RP-1546

N
O

Pricing

HO

OH

Purity: 98% +C12H15N3O5Mol. Wt.: 281.

N3-Methyl-cytidine

CAS No. 2140-64-9

N
HO
O

OH

OH

O

Pricing$162.00 / 100 mg$720.00 / 1 g
Triphosphates$150.00 / 10 mg$360.00 / 25 mg

O

Reagents

5-Propynyl-uridine

5-Propynyl-cytidineOH

DMT-protected
Nucleosides$34.00 / 25 mg$105.00 / 100 mg$38.00 / 25 mg$125.00 / 100 mg

N

N-protected
Nucleosides

Modified Ribo Nucleosides

Purity: 98% +C12H14N2O6
Mol. Wt: 282.2

N3-Methyl-uridine CAS No. 2140-69-4
Catalog#
SugarsCatalog#

RP-1034

RP-2317

Pricing

Pricing$65.00 / 25 mg$180.00 / 100 mg$115.00 / 25 mg$380.00 / 100 mg

Purity: 98% +NHS Esters

Purity: 98% +N6-Palmitoyl-adenosine
Catalog#

O
14

N
N

RP-1041

NH
N
N

HO
O
OH OH
C26H43N5O5
Mol. Wt.: 505.65

Pricing$350.00 / 1 g$748.00 / 5 g

Purity: 98% +152

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Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
Modified Ribo Nucleosides
2,2’-Anhydro-5-methyl-cytidine

2,2’-Anhydro-uridine(β-D-2,2’-O-cyclouridine)

Catalog#
NHO

RP-4807

N
O

N

O
OH
C9H10N2O5
Mol. Wt.: 226

RP-4808

N

PricingO$30.00 / 1 g$125.00 / 5 g

HO

Purity: 98% +CAS No. 3736-77-4

Catalog#

N

HO
O
OH
C10H13N3O4
Mol. Wt.: 239.2

Pricing$50.00 / 1 g$205.00 / 5 g

Purity: 98% +2,2’-Anhydro-cytidine.HCl; Ancitabine hydrochloride
Catalog#
Cl NH2

RP-3765

N
O

N

HO
O
OH
C9H12ClN3O4
Mol. Wt.: 261.

Pricing$40.00 / 1 g$172.00 / 5 g

Purity: 98% +CAS No. 10212-25-6

153

Toll Free: (800) 762-9323
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Unprotected
Nucleosides

Unprotected Nucleosides

Product Name
β-L-Adenosine M.W. 267.24
β-L-Cytidine M.W. 243.22
β-L-Guanosine M.W. 283.24
β-L-Uridine M.W. 244.20
β-L-ribo Thymidine M.W. 258.23
β-L-Inosine M.W. 268.23

100mg$65.00$65.00$78.00$65.00$75.00$78.00500mg$148.00$148.00$152.00$148.00$152.00$152.00

1g$285.00$285.00$326.00$285.00$310.00$326.00

5g$1,160.00$1,160.00$1,467.00$1,160.00$1,395.00$1,467.00

Reagents

Catalog#RP-9031RP-9032
RP-9033
RP-9034
RP-9035
RP-9036

Catalog#RP-9031RP-9032
RP-9033
RP-9034
RP-9035
RP-9036

DMT-protected
Nucleosides

B
A
C
G
U
T
I

N-protected
Nucleosides

β-L Ribo Nucleosides

7-Deaza Ribo Nucleosides

7-Deaza-adenosine; Tubercidin

CAS No. 69-33-0

7-Deaza-guanosine

Catalog#

RP-2312

RP-2313

Pricing

Pricing$112.00 / 100 mg$225.00 / 250 mg$720.00/ 1 g

Purity: 98% +Purity: 98% +Ara-7-Deaza-guanosine
Catalog#

RP-2314O

RP-4311

NH

Pricing

Purity: 98% +

N

N

NH2

HO
O
OH
OH
C11H14N4O5
Mol. Wt.: 282.25

7-Deaza-7-iodo-adenosine; 7-Iodo-tubercidin

N

Catalog#N

RP-2316

N

HO
O
OH OH
C11H13IN4O4
Mol. Wt.: 392.15

Pricing$175.00 / 100 mg$330.00 / 250 mg$804.00 / 1 g

NHS Esters$175.00 / 100 mg$330.00 / 250 mg$804.00 / 1 g

NH2

SugarsCAS No. 2862-16-0

Catalog#

I

Triphosphates

Catalog#$132.00 / 100 mg$260.00 / 250 mg$830.00 / 1 g

7-Deaza-inosine

CAS No. 62160-23-0

Purity: 98% +Pricing$175.00 / 100 mg$350.00 / 250 mg$1,120.00 / 1 g

Purity: 98% +154

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Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
2’-O-Methyl Ribo Nucleosides
2’-O-Methyl Ribo Nucleosides
B
A
C
G
U
I
T
Catalog#
RP-1901
RP-1902
RP-1903
RP-1904
RP-1906
RP-1908

Product Name
2’-O-Methyl-adenosine M.W. 281.27
2’-O-Methyl-cytidine M.W. 257.24
2’-O-Methyl-guanosine M.W. 297.27
2’-O-Methyl-uridine M.W, 258.23
2’-O-Methyl-inosine M.W, 282.25
2’-O-Methyl-thymidine M.W, 272.25

2’-O-Methyl-5-iodo-uridine

Catalog#
RP-1901
RP-1902
RP-1903
RP-1904
RP-1906
RP-1908100mg$38.00$38.00$38.00$20.00$48.00$42.00CAS No.
2140-79-6
2140-72-9
2140-71-8
2140-76-3
3881-21-8500mg$53.00$53.00$53.00$30.00$190.00$165.00

1g$95.00$95.00$95.00$55.00$300.00$260.00

5g$381.00$381.00$381.00$220.00$1,050.00$1,005.00

2’-O-Methyl-5-methyl-cytidine

CAS No. 34218-84-3

Catalog#Catalog#

RP-1905

RP-1907

Pricing

Pricing$ 112.00 / 100 mg$725.00 / 1 g$168.00 / 100 mg$1345.00 / 1 g

Purity: 98% +Purity: 98% +β-L-2’-O-Methyl-2-amino-adenosine

2’-O-Methyl-L-uridine
Catalog#Catalog#

RP-1909

RP-3902

Pricing

Pricing$ 112.00 / 100 mg$725.00 / 1 g$ 112.00 / 100 mg$725.00 / 1 g

Purity: 98% +Purity: 98% +Note: For protected base please refer to page 160

155

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33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

10g$665.00$665.00$665.00$400.00$1,470.00$1,400.00

Unprotected
Nucleosides
Unprotected
Nucleosides

2’-O-Methyl-5-propynyl-cytidine

N-protected
Nucleosides

2’-O-Methyl Ribo Nucleosides
2’-O-Methyl-5-propynyl-uridine
Catalog#

RP-1548

RP-1856

Pricing

Pricing$210.00 / 10 mg$1,365.00 / 100 mg$108.00 / 10 mg$750.00 / 100 mg

Purity: 98% +Purity: 98% +DMT-protected
Nucleosides

Catalog#Catalog#Catalog#

RP-2911

RP-2912

Pricing

Pricing$50.00 / 10 mg$350.00 / 100 mg$44.00 / 10 mg$305.00 / 100 mg

Purity: 98% +Purity: 98% +CAS No. 10300-27-3

3’-O-Methyl-uridine
Catalog#

RP-2913

RP-2914

Pricing

Pricing$55.00 / 10 mg$360.00 / 100 mg$32.00 / 10 mg$250.00 / 100 mg

Purity: 98% +Purity: 98% +CAS No. 75479-64-0

NHS Esters

Catalog#

Sugars3’-O-Methyl-inosine

3’-O-Methyl-cytidine

Triphosphates

3’-O-Methyl-guanosine

Reagents

3’-O-Methyl Ribo Nucleosides
3’-O-Methyl-adenosine

Unprotected
Nucleosides

Nucleosides & Reagents

3’-O-Methyl-5-methyl-cytidine

Catalog#Catalog#

RP-2915

RP-2916

Pricing

Pricing$60.00 / 10 mg$420.00 / 100 mg$70.00 / 10 mg$555.00 / 100 mg

Purity: 98% +Purity: 98% +156

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Nucleosides

Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
2’-O-Allyl Ribo Nucleosides
2’-O-Allyl-adenosine

2’-O-Allyl-guanosine

2’-O-Allyl-cytidine
Catalog#Catalog#

RP-3511

RP-3512

Pricing

Pricing$44.00 / 10 mg$308.00 / 100 mg$44.00 / 10 mg$308.00 / 100 mg

Purity: 98% +Purity: 98% +CAS No. 133766-28-6

2’-O-Allyl-uridine

CAS No. 133766-24-2

Catalog#Catalog#

RP-3513

RP-3514

Pricing

Pricing$44.00 / 10 mg$308.00 / 100 mg$38.00 / 10 mg$266.00 / 100 mg

Purity: 98% +Purity: 98% +3’-O-Allyl Ribo Nucleosides
3’-O-Allyl-adenosine

3’-O-Allyl-cytidine
Catalog#Catalog#

RP-3111

RP-3112

Pricing

Pricing$48.00 / 10 mg$336.00 / 100 mg$46.00 / 10 mg$322.00 / 100 mg

Purity: 98% +Purity: 98% +3’-O-Allyl-guanosine

3’-O-Allyl-uridine
Catalog#Catalog#

RP-3113

RP-3114

Pricing

Pricing$52.00 / 10 mg$364.00 / 100 mg$46.00 / 10 mg$322.00 / 100 mg

Purity: 98% +Purity: 98% +157

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected
Nucleosides

Unprotected
Unproteced

Nucleosides & Reagents
Unprotected Nucleosides

Unprotected Nucleosides

2’-O-Propargyl-adenosine

CAS No. 151390-97-5

2’-O-Propargyl-cytidine

Catalog#
RP-3401NN

RP-3402

N
O

N

Pricing

HO

HO

OH

O

$60.00 / 10 mg$420.00 / 100 mg

O
O

OH

Purity: 98% +C13H15N5O4
Mol. Wt: 305.29

2’-O-Propargyl-guanosine

C12H15N3O5Mol. Wt.: 281.2

Pricing

NH2

HO

OH

O

O

N

Pricing

HO
O

OH$50.00 / 10 mg$350.00 / 100 mg

O

C12H14N2O6
Mol. Wt.: 282.25

Triphosphates

Purity: 98% +C13H15N5O5Mol. Wt: 321.29

RP-3404NH$60.00 / 10 mg$420.00 / 100 mg

O

Reagents

N

Catalog#O

RP-3403

NH

Purity: 98% +2’-O-Propargyl-uridine
Catalog#N$60.00 / 10 mg$420.00 / 100 mg

O

O
N

DMT-protected
Nucleosides

PricingN

Catalog#

NH2

NH2
N

N-protected
Nucleosides

2’-O-Propargyl Ribo Nucleosides

Purity: 98% +3’-O-Propargyl Ribo Nucleosides
3’-O-Propargyl-adenosine
NH2

Catalog#

NH2

N

RP-3301

N

PricingNHO

3’-O-Propargyl-guanosineN

C12H15N3O5Mol. Wt.: 281.26

HO

NH2

Pricing$52.00 / 10 mg$364.00 / 100 mg

O
OH

Purity: 98% +C13H15N5O5Mol. Wt: 321.29

Purity: 98% +3’-O-Propargyl-uridine
Catalog#ONH

RP-3303NHN$46.00 / 10 mg$322.00 / 100 mg

OH

Catalog#

O
N

O

O

NHS Esters

Purity: 98% +PricingO

OH

C13H15N5O4
Mol. Wt: 305.29

RP-3302
O

HO$48.00 / 10 mg$336.00 / 100 mg

OONCatalog#

SugarsNN

3’-O-Propargyl-cytidine

N

O

O

O

RP-3304

PricingHO

OH

C12H14N2O6
Mol. Wt.: 282.25$46.00 / 10 mg$322.00 / 100 mg

Purity: 98% +158

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Nucleosides

Nucleosides & Reagents
Unprotected
Unprotected
Nucleosides
Nucleosides
Bis-Silyl Ribo Nucleosides
B
O
Si

O

O
O
Si

Catalog#
RP-8871
RP-8872
RP-8873
RP-8874

OH

Bis Silyl ribo Nucleosides
B
A
C
G
U

Catalog#
RP-8871
RP-8872
RP-8873
RP-8874

Product Name
5’,3’-Tetraisopropyl-disiloxane-adenosine M.W. 509.75
5’,3’-Tetraisopropyl-disiloxane-cytidine M.W. 484.73
5’,3’-Tetraisopropyl-disiloxane-guanosine M.W. 525.75
5’,3’-Tetraisopropyl-disiloxane-uridine M.W. 486.71

100mg$38.00$38.00$38.00$24.001g$95.00$95.00$95.00$55.005g$410.00$410.00$410.00$220.00

For Nucleoside base protected Bis-Silyl ribonucleotides, please refer to page159

159

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

10g$740.00$740.00$740.00$400.00

Unprotected
Nucleosides

Unprotected

Nucleosides & Reagents

N-protected Nucleosides
N-protected Nucleosid
N-protected Nucleosides

1g$12.00$12.00$15.00$15.00$18.00$22.00$22.00$22.00$15.00$15.005g$55.00$55.00$60.00$70.00$85.00$82.00$82.00$82.00$65.00$65.0032909-05-0

10g$99.00$99.00$108.00$126.00$153.00$148.00$148.00$148.00$117.00$117.00

Triphosphates

Product Name
2’-Deoxyadenosine (N-Bz) M.W. 355.35
2’-Deoxycytidine (N-Bz) M.W. 331.32
2’-Deoxyguanosine (N-iBu) M.W. 337.33
2’-Deoxycytidine (N-iBu) M.W, 297.31
2’-Deoxycytidine (N-Ac) M.W. 269.25
2’-Deoxyadenosine (N-PAC) M.W. 385.37
2’-Deoxycytidine (N-PAC) M.W. 361.35
2’-Deoxyguanosine (N-PAC) M.W. 401.37
2’-Deoxyadenosine (N-DMF) M.W. 306.32
2’-Deoxyguanosine (N-DMF) M.W. 322.32

CAS No.
305808-19-9
4836-13-9
68892-42-2

Reagents

Catalog#PM-1101
PM-1102
PM-1103
PM-1104
PM-1105
PM-9996
PM-9997
PM-9998
PM-1588
PM-3183

ProtectionCatalog#
N-Bz
PM-1101
N-Bz
PM-1102
N-iBu
PM-1103
N-iBu
PM-1104
N-Ac
PM-1105
N-PAC
PM-9996
N-PAC
PM-9997
N-PAC
PM-9998
N-DMF
PM-1588
N-DMF
PM-3183

DMT-protected
Nucleosides

B
A
C
G
C
C
A
C
G
A
G

N-protected
Nucleosides

Base Protected (Standard & Labile) deoxy Nucleosides

NHS Esters

160

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Nucleosides & Reagents
N-protected
N-protected
Nucleosides
Nucleosides
Base Protected (Standard & Labile) Ribo Nucleosides
B
A
C
G
C
C
A
C
G

Catalog#PM-2101
PM-2102
PM-2103
PM-2105
PM-2106
PM-6001
PM-6002
PM-6003

ProtectionCatalog#
N-Bz
PM-2101
N-Bz
PM-2102
N-iBu
PM-2103
N-iBu
PM-2105
N-Ac
PM-2106
N-PAC
PM-6001
N-PAC
PM-6002
N-PAC
PM-6003

Productname
Adenosine (N-Bz) M.W. 371.35
Cytidine (N-Bz) M.W. 347.32
Guanosine (N-iBu) M.W. 353.33
Cytidine (N-iBu) M.W, 313.31
Cytidine (N-Ac) M.W. 285.25
Adenosine (N-PAC) M.W. 401.37
Cytidine (N-PAC) M.W. 377.35
Guanosine (N-PAC) M.W. 417.37

CAS No.
4546-55-813089-48-0
64350-24-9
3768-18-1

1g$27.00$27.00$33.00$33.00$37.00$40.00$40.00$40.005g$125.00$125.00$130.00$130.00$155.00$180.00$180.00$180.00

10g$200.00$200.00$210.00$210.00$245.00$290.00$290.00$290.00

Purity : All the above products have a purity of 98% +N-Phenylacetyl Guanosine

CAS No. 132628-16-1

N-DBF Isoguanosine
Catalog#Catalog#N

PM-6004

N
N

Pricing$40.00 / 1 g$180.00 / 5 g

Purity: 98% +NBu2

PM-2643

NH
N

O

Pricing

HO
O
OH$23.00 / 10 mg$165.00 / 100 mg$310.00 / 250 mg

OH

C19H30N6O5
Mol. Wt: 422.48

Purity: 98% +N-Isopentyl Adenosine

5-Methyl-N-Benzoyl Cytidine

CAS No. 7724-76-7

Catalog#Catalog#PM-4122

PM-6005

Pricing

Pricing$32.00 / 25 mg$75.00 / 100 mg$455.00 / 1 g$32.00 / 25 mg$75.00 / 100 mg$455.00 / 1 g

Purity: 98% +Purity: 98% +161

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Unprotected
Nucleosides

N-protected Nucleosides

B
O
Si

O
O

OH

Si

RP-4128

NH
NHiBu

N

HO

N

RP-4127

N

HO

PricingO

Purity: 98% +C20H21N5O5
Mol. Wt.: 411.41

2’,3’-Isopropylidene-uridine
O
NH
N

10g
$892.00$892.00$892.00$892.00$892.00$892.00$892.00$892.00$48.00 / 5 g$152.00 / 25 g

O

Purity: 98% +C17H23N5O6
Mol. Wt.: 393.39

O

HO
O
O

Catalog#

Pricing

O

O

NHBz
N
N

$48.00 / 5 g$152.00 / 25 g

O

5g
$405.00$405.00$405.00$405.00$405.00$405.00$405.00$405.00

NHS Esters

N

1g$98.00$98.00$98.00$98.00$98.00$98.00$98.00$98.002’,3’-Isopropylidene-adenosine (N-Bz)

Catalog#

O
N

100mg
$44.00$44.00$44.00$44.00$44.00$44.00$44.00$44.00O

CAS No. 362-43-6

2’,3’-Isopropylidene-cytidine

Catalog#Catalog#RP-4129

RP-4126

Pricing

Pricing$48.00 / 5 g$152.00 / 25 g

$48.00 / 5 g$152.00 / 25 g

Purity: 98% +Purity: 98% +C12H16N2O6
Mol. Wt.: 284.2

162

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Triphosphates

Product Name
5’,3’-Tetraisopropyl-disiloxane-adenosine (N-iBu) M.W.579.84
5’,3’-Tetraisopropyl-disiloxane-adenosine (N-PAC) M.W. 643.88
5’,3’-Tetraisopropyl-disiloxane-adenosine (N-Bz) M.W. 613.85
5’,3’-Tetraisopropyl-disiloxane-cytidine (N-Ac) M.W, 527.76
5’,3’-Tetraisopropyl-disiloxane-cytidine (N-iBu) M.W. 555.81
5’,3’-Tetraisopropyl-disiloxane-guanosine (N-DMF) M.W. 580.82
5’,3’-Tetraisopropyl-disiloxane-guanosine (N-Ac) M.W. 567.78
5’,3’-Tetraisopropyl-disiloxane-guanosine (N-iBu) M.W. 595.84

2’,3’-Isopropylidene-guanosine (N-iBu)

O

Catalog#PM-1921
PM-1922
PM-1928
PM-1923
PM-1924
PM-1925
PM-1926
PM-1927

Reagents

Catalog#PM-1921
PM-1922
PM-1928
PM-1923
PM-1924
PM-1925
PM-1926
PM-1927

Protection
N-iBu
N-PAC
N-Bz
N-Ac
N-iBu
N-DMF
N-Ac
N-iBu

DMT-protected
Nucleosides

O

B
A
A
A
C
C
G
G
G

N-protected
Nucleosides

Bis-Silyl ribo Nucleosides with Standard & Labile Base Protection

N-protectedN-protected
Nucleosides
N-protected
Nucleosides
Nucleosides
Protected Ribo Nucleosides
B
A
C
C
T
G
U

Catalog#RP-2278
RP-2279
RP-2280
RP-2283
RP-2282
RP-2249

Protection
N-Bz
N-Bz
N-Ac
N/A
N-iBu
N/A

Product Name
2’,3’-O-Diacetyl-adenosine (N-Bz) M.W.455.42
2’,3’-O-Diacetyl-cytidine (N-Bz) M.W. 431.40
2’,3’-O-Diacetyl-cytidine (N-Ac) M.W. 369.33
2’,3’-O-Diacetyl-ribothymidine M.W, 342.30
2’,3’-O-Diacetyl-guanosine (N-iBu) M.W. 437.40
2’,3’-O-Diacetyl-uridine M.W. 328.27

Catalog#RP-2278
RP-2279
RP-2280
RP-2283
RP-2282
RP-22491g$90.00$90.00$90.00$90.00$90.00$65.005g$360.00$360.00$360.00$360.00$360.00$260.00

10g$575.00$575.00$575.00$575.00$575.00$410.00

Modified Ribo Nucleosides
N-Ethyl Adenosine

3’-O-Allyl-N-Benzoyl Cytidine
Catalog#Catalog#

RP-1035

RP-3115

Pricing

Pricing$32.00 / 25 mg$75.00 / 100 mg$455.00 / 1 g$32.00 / 25 mg$75.00 / 100 mg$455.00 / 1 g

Purity: 98% +Purity: 98% +2,2’-Anhydro-5-Methyl-N-Benzoyl Cytidine

2’-O-Methyl-N,N’-dimethyl Adenosine

Catalog#
NBz

RP-4166

N
O

N

HO
O
OH
C17H17N3O5
Mol. Wt: 343.33

Pricing

Catalog#
RP-3901$32.00 / 25 mg$75.00 / 100 mg$455.00 / 1 g

Pricing

Purity: 98% +Purity: 98% +$168.00 / 100 mg$1345.00 / 1 g

163

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Toll Free: (800)762-9323
33 Industrial Way,
Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
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Unprotected
Nucleosides

Nucleosides & Reagents
N-protected
Nucleosides
N-protected
Nucleosides

5’-O-Levulinyl-2’-deoxyadenosine (N-Bz)

5’-O-Levulinyl-2’-deoxycytidine (N-Bz)
Catalog#

DN-6601

DN-6602

Pricing

Pricing$40.00 / 1 g$180.00 / 5 g$40.00 / 1 g$180.00 / 5 g

Purity: 98% +Purity: 98% +5’-O-Levulinyl-2’-deoxyguanosine (N-iBu)

5’-O-Levulinyl-thymidine

DN-6603

DN-6604

Pricing

Pricing$40.00 / 1 g$180.00 / 5 g$35.00 / 1 g$160.00 / 5 g

Purity: 98% +Purity: 98% +3’-O-Levulinyl deoxy Nucleosides
3’-O-Levulinyl-2’-deoxycytidine (N-Bz)
Catalog#PM-6611PM-6612

Pricing

Pricing$100.00 / 1 g$475.00 / 5 g$100.00 / 1 g$475.00 / 5 g

Purity: 98% +Purity: 98% +NHS Esters

Catalog#

3’-O-Levulinyl-2’-deoxyguanosine (N-iBu)

Triphosphates

Catalog#

Reagents

Catalog#

3’-O-Levulinyl-2’-deoxyadenosine (N-Bz)

DMT-protected
Nucleosides

Catalog#

N-protected
Nucleosides

5’-O-Levulinyl deoxy Nucleosides

3’-O-Levulinyl-thymidine

Catalog#Catalog#PM-6613

PM-6614

Pricing

Pricing$100.00 / 1 g$475.00 / 5 g$90.00 / 1 g$425.00 / 5 g

Purity: 98% +Purity: 98% +164www.chemgenes.com
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Nucleosides & Reagents
N-protected
N-protected
Nucleosides
Nucleosides
3’-O-Acetyl deoxy Nucleosides
3’-O-Acetyl-2’-deoxyadenosine (N-Bz)

3’-O-Acetyl-2’-deoxycytidine (N-Bz)

Catalog#Catalog#PM-6301

PM-6302

Pricing

Pricing$90.00 / 1 g$425.00 / 5 g$90.00 / 1 g$425.00 / 5 g

Purity: 98% +Purity: 98% +3’-O-Acetyl-2’-deoxyguanosine (N-iBu)

3’-O-Acetyl-thymidine

3’-O-Acetyl-2’-deoxyuridine CAS No. 23197-88-8

Catalog#Catalog#PM-6303

PM-6305

Pricing

Pricing$90.00 / 1 g$425.00 / 5 g$45.00 / 1 g$212.00 / 5 g

Purity: 98% +Purity: 98% +CAS No. 21090-30-2

Catalog#PM-6304

Pricing$45.00 / 1 g$212.00 / 5 g

Purity: 98% +165

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

5g$80.00$80.00$80.00$52.00$80.00$80.00$112.00$112.00$112.00$126.00$190.00$190.00$190.00$190.00$190.00$190.00$190.00$190.00$112.00$112.00$112.00

40615-39-2

10g$145.00$145.00$145.00$92.00$145.00$145.00$198.00$198.00$198.00$224.00$342.00$342.00$342.00$342.00$342.00$342.00$342.00$342.00$198.00$198.00$198.00

100g$1,200.00$1,200.00$1,200.00$850.00$1,200.00$1,200.00$1,782.00$1,782.00$1,782.00$2,000.00$3,000.00$3,000.00$3,000.00$3,000.00$3,000.00$3,000.00$3,000.00$3,000.00$1,782.00$1,782.00$1,782.00

Purity: Ultrapure product: > 98.5% + by HPLC
166

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NHS Esters

1g$18.00$18.00$18.00$12.00$18.00$18.00$25.00$25.00$25.00$28.00$40.00$40.00$40.00$40.00$40.00$40.00$40.00$40.00$25.00$25.00$25.00CAS No.

Triphosphates

Product Name
5’-O-DMTr-2’-deoxyadenosine (N-Bz) M.W. 657.71
5’-O-DMTr-2’-deoxycytidine (N-Bz) M.W. 633.69
5’-O-DMTr-2’-deoxyguanosine (N-iBu) M.W. 639.70
5’-O-DMTr-thymidine M.W, 544.60
5’-O-DMTr-2’-deoxycytidine (N-iBu) M.W. 599.67
5’-O-DMTr-2’-deoxycytidine (N-Ac) M.W. 571.82
5’-O-DMTr-2’-deoxyadenosine (N-Ac)M.W. 595.65
5’-O-DMTr-2’-deoxyadenosine (N-PAC)M.W. 687.74
5’-O-DMTr-2’-deoxycytidine (N-PAC) M.W. 663.7
5’-O-DMTr-2’-deoxyguanosine (N-PAC)M.W. 703.74
5’-O-DMTr-2’-deoxyguanosine (N-tBPAC)M.W. 759.85
5’-O-DMTr-2’-deoxyguanosine (N-iPrPAC)M.W. 745.82
5’-O-DMTr-2’-deoxyinosine M.W. 554.59
5’-O-DMTr-2’-deoxyuridineM.W. 530.57
5’-O-DMTr-2’-deoxyadenosine(N6-tBPAC) M.W. 743.85
5’-O-DMTr-2’-deoxycytidine (N4-tButyl PAC) M.W. 719.82
5’-O-DMTr-2’-deoxyadenosine (N-iBu) M.W. 623.70
5’-O-DMTr-2’-deoxycytidine (N-CNEt) M.W. 582.65
5’-O-DMTr-2’-deoxyadenosine (N-Fmoc) M.W. 775.85
5’-O-DMTr-2’-deoxycytidine (N-Fmoc) M.W. 751.82
5’-O-DMTr-2’-deoxyguanosine (N-Fmoc) M.W. 791.85

Catalog#PM-1109
PM-1110
PM-1111
PM-1112PM-1117
PM-1118
PM-3015
PM-3101
PM-3102
PM-3103
PM-1483
PM-1484
PM-1119
PM-1120
PM-1481PM-1482
PM-1487
PM-1489
PM-4321
PM-4322
PM-4333

Reagents

Catalog#PM-1109
PM-1110
PM-1111
PM-1112PM-1117
PM-1118
PM-3015
PM-3101
PM-3102
PM-3103
PM-1483
PM-1484
PM-1119
PM-1120
PM-1481PM-1482
PM-1487
PM-1489
PM-4321
PM-4322
PM-4333

Protection
N-Bz
N-Bz
N-iBu
N/A
N-iBu
N-Ac
N-Ac
N-PAC
N-PAC
N-PAC
N-tBPACN-iPrPAC
N/A
N/A
N-tBPAC
N-tBPAC
N-iBu
N-Cyanoethyl
N-FmocN-FmocN-FmocDMT-protected
Nucleosides

B
A
C
G
T
C
C
A
A
C
G
G
G
I
U
A
C
A
C
A
C
G

N-protected
Nucleosides

DMT Protected and base Protected (Standard & Labile)
deoxy Nucleosides

Unprotected
Nucleosides

N-protected Nucleosides
DMT-protected Nucleosides

Nucleosides
DMT-protected Nucleosides

DMT Protected Standard & Labile Ribo Nucleosides
B
A
C
G
U
C
C
A
C
G
T
I
G
G
A
C
G
Catalog#PM-2109
PM-2110PM-2111PM-2112PM-2113
PM-2114PM-2203
PM-2204
PM-2205
PM-2115
PM-2306
PM-2209
PM-4003
PM-4366
PM-4367
PM-4368

Protection
N-Bz
N-Bz
N-iBu
N/A
N-iBu
N-Ac
N-PAC
N-PAC
N-PAC
N/A
N/A
N-iPrPAC
N-Ac
N-FmocN-FmocN-FmocProduct Name
1g
5’-O-DMTr-Adenosine (N-Bz) M.W. 673.71$33.005’-O-DMTr-Cytidine (N-Bz) M.W. 649.69$33.005’-O-DMTr-Guanosine (N-iBu) M.W. 655.70$35.005’-O-DMTr-Uridine M.W, 546.57$26.005’-O-DMTr-Cytidine (N-iBu) M.W. 615.67$40.005’-O-DMTr-Cytidine (N-Ac) M.W. 587.82$42.005’-O-DMTr-Adenosine (N-PAC) M.W. 703.74$35.005’-O-DMTr-Cytidine (N-PAC) M.W. 679.72$35.005’-O-DMTr-Guanosine (N-PAC) M.W. 719.74$35.005’-O-DMTr-riboThymidine M.W. 560.59$35.005’-O-DMTr-Inosine M.W. 570.59$35.005’-O-DMTr-Guanosine (N-iPrPAC) M.W. 761.31 $35.00
5’-O-DMTr-Guanosine (N-Ac) M.W. 627.64$35.005’-O-DMTr-Adenosine (N-Fmoc) M.W. 791.85 $25.00
5’-O-DMTr-Cytidine (N-Fmoc) M.W. 767.82$25.005’-O-DMTr-Guanosine (N-Fmoc) M.W. 807.85 $25.00

Catalog#PM-2109
PM-2110PM-2111PM-2112PM-2113
PM-2114PM-2203
PM-2204
PM-2205
PM-2115
PM-2306
PM-2209
PM-4003
PM-4366
PM-4367
PM-43685g$142.00$142.00$148.00$128.00$142.00$145.00$148.00$148.00$148.00$148.00$148.00$148.00$148.00$112.00		
$112.00		
$112.00		

CAS No.
81246-82-4

10g$256.00$256.00$265.00$230.00$333.00$245.00$245.00$245.00$245.00$245.00$245.00$245.00$245.00$198.00$198.00$198.00

Purity: All the above produced have a purity of 98.5% + by HPLC

167

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100g$2,170.00$2,170.00$2,250.00$1,955.00$2,830.00$2,080.00$2,080.00$2,080.00$2,080.00$2,080.00$2,080.00$2,080.00$2,080.00$1,680.00$1,680.00$1,680.00

Unprotected
Nucleosides

DMT-protected Nucleosides
5’-O-DMTr-5-propynyl-2’-deoxycytidine (N-Bz)

Catalog#O

N-protected
Nucleosides

5’-O-DMTr-5-propynyl-2’-deoxyuridine

Catalog#
NHBz

PM-1022NH

DMTrO

PM-1124

N

PricingO

N

Pricing

O

N
DMTrO

OH

OH

Purity: 98% +C33H32N2O7
Mol. Wt.: 568.62$110.00 / 100 mg$905.00 / 1 g

O

Purity: 98% +C40H37N3O7Mol. Wt.: 671.74

5’-O-DMTr-N3-methyl-thymidine

5’-O-DMTr-N6-methyl-2’-deoxyadenosine

Catalog#O

N

PricingO$65.00 / 1 g$216.00 / 5 g

OPurity: 98% +OH

5’-O-DMTr-2’-deoxy-isoguanosine (N-DBF)

NBu2

N

N
DMTrO

$45.00 / 1 g$200.00 / 5 g

OOH
C32H33N5O5
Mol. Wt.: 567.63

Catalog#

NHBz

PM-1643

N

Catalog#

O

Pricing$425.00 / 1 g

DMTrO
O

N

PM-1967

Pricing

DMTrO
O

Purity: 98% +OHO$45.00 / 1 g$200.00 / 5 g

OH

Purity: 98% +C38H37N3O7Mol. Wt.: 647.7

C40H48N6O6
Mol. Wt.: 708.85

5’-O-DMTr-2’-deoxycytidine (N-Cyanoethyl)

NHS Esters

N

Purity: 98% +5’-O-DMTr-5-methyl-2’-deoxycytidine (N-Bz)

NH

N

PM-1107

PricingN

Triphosphates

C32H34N2O7
Mol. Wt: 558.62

NN

Reagents

N
DMTrO

Catalog#NH

PM-1591

N

DMT-protected
Nucleosides$165.00 / 100 mg$800.00 / 1 g

O

5’-O-DMTr-N3-cyanoethyl-thymidine

Catalog#
CN
HN

PM-1489

N

Catalog#O
CN

N

Pricing
O

DMTrO
O
OH
C33H34N4O6
Mol. Wt.: 582.65$65.00 / 1 g$216.00 / 5 g

Purity: 98% +N
N

PM-1490
O

DMTrO
O
OH
C34H35N3O7
Mol. Wt.: 597.66

Pricing$65.00 / 1 g$216.00 / 5 g

Purity: 98% +168

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DMT-protected Nucleosides
DMT-protected Nucleosides
DMTr Protected Modified Deoxy Nucleosides
5’-O-DMTr-7-Deaza-2’-deoxyinosine

5’-O-DMTr-7-Deaza-2’-deoxyguanosine (N-iBu)

Catalog#Catalog#PM-6434

PM-6433

Pricing

Pricing$450.00 / 1 g$1,800.00 / 5 g$450.00 / 1 g$1,800.00 / 5 g

Purity: 98% +Purity: 98% +

O
NH
N

N

DMTrO
O
OH
C32H31N3O6
Mol. Wt.: 553.61

5’-O-DMTr-7-Deaza-2’-deoxyadenosine (N-Bz)
Catalog#
NHBz
N
N

N

DMTrO
O
OH

PM-6431

Pricing$450.00 / 1 g$1,800.00 / 5 g

Purity: 98% +C39H36N4O6
Mol. Wt.: 656.73

169

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Unprotected
Nucleosides

Nucleosides
DMT-protected Nucleosides
DMT-protected Nucleosides

N-protected
Nucleosides

DMTr Protected Modified Deoxy Nucleosides
5’-O-DMTr-3’-Azido-7-deaza-7-propargyl-amino-(TFA)-2’-deoxyguanosine
O
F3C

Catalog#
DMT-protected
Nucleosides

NH

PM-7307
O
NH
N

DMTrO

N

Pricing

NHPAC

O$315.00 / 100 μmole

Purity: 98% +Reagents

N3
C45H39F3N8O8
Mol. Wt.: 876.84

Triphosphates
NHS Esters

170

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DMT-protected
Nucleosides
DMT-protected
Nucleosides
DMTr Protected Modified Deoxy Nucleosides
5’-O-DMTr-8-bromo-2’-deoxyadenosine (N-DBF)
NBu2

N
N

Catalog#

Br

N

DMTrO

$165.00 / 1 g$650.00 / 5 g

OOH

Purity: 98% +C40H47BrN6O5
Mol. Wt.: 771.74

5’-O-DMTr-8-bromo-2’-deoxyguanosine (N-iBu)

N$150.00 / 1 g$600.00 / 5 g

OOH
C38H34BrN5O6
Mol. Wt: 736.61

N

NHiBu

DMTrO

PricingOH
C35H36BrN5O7
Mol Wt.: 718.59

Purity: 98% +5’-O-DMTr-5-iodo-2’-deoxycytidine (N-DBF)

Catalog#OBrPM-2808

NH
N

O

DMTrO

$150.00 / 1 g$600.00 / 5 g

OOH
C30H29BrN2O7
Mol. Wt: 609.46

N

Catalog#O

PM-1979
O

DMTrO
O
OH

NH

Pricing$115.00 / 100 mg

PM-2864

I
N

O

DMTrO
O

Purity: 98% +OH

C39H47IN4O6
Mol. Wt.: 794.72

Purity: 98% +CAS No. 104375-88-4
5’-O-DMTr-5-iodo-2’-deoxyuridine

Catalog#N

Pricing$45.00 / 1 g$186.00 / 5 g

O

NBu2

N
I

Purity: 98% +5’-O-DMTr-5-bromo-2’-deoxyuridine

PM-7211NH

Br

PM-7210

PricingN

DMTrO

Catalog#

O
N

N

Br

PricingN

N

Catalog#
NHBz

PM-4791NN

5’-O-DMTr-8-bromo-2’-deoxyadenosine (N-Bz)

C30H29IN2O7
Mol. Wt.: 656.4

Pricing$45.00 / 1 g$186.00 / 5 g

Purity: 98% +171

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Unprotected
Nucleosides

Nucleosides
DMT-protected
Nucleosides
DMT-protected
Nucleosides

5’-O-DMTr-8-bromo-adenosine (N-DBF)

5’-O-DMTr-5-methyl-cytidine (N-Bz)

Catalog#NN

C40H47BrN6O6
Mol. Wt: 787.74$134.00 / 1 g

OH OH

Purity: 98% +C38H37N3O8
Mol. Wt.: 663

5’-O-DMTr-5-propynyl-cytidine (N-Bz)

5’-O-DMTr-5-propynyl-uridine
Catalog#O

PM-1126

N

NH

Pricing

O

DMTrO

N

OH OH
C40H37N3O8
Mol. Wt.: 687

O

DMTrO
O

Purity: 98% +OH OH
C33H32N2O8
Mol. Wt.: 584

PM-1024

Pricing$180.00 / 100 mg$1,260.00 / 1 g

Triphosphates$115.00 / 100 mg$910.00 / 1 g

OReagents

Catalog#
NHBz

N

PricingO

DMTrO

Purity: 98% +OH

O

DMT-protected
Nucleosides

N$160.00 / 1 g

OPM-2647

N

Pricing

N

DMTrO

OH

NHBz

PM-1834

N

N

Catalog#

NBu2

Br

N-protected
Nucleosides

DMTr Protected Modified Ribo

Purity: 98% +5’-O-DMTr-2,6-diamino-purine-riboside (N6-DMF) (N2-iBu)
Catalog#NN

PM-2476

PricingN
N

NHS Esters

NMe2

N

NHiBu

$115.00 / 1 g

DMTrO

Purity: 98% +

O
OH

OH

C38H43N7O7
Mol. Wt: 709.79

172

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DMT-protectedNucleosides
Nucleosides
DMT-protected
DMTr Protected 2’-O-Methyl Nucleosides

B
DMTrO
O
OH OCH3
Catalog#PM-5731
PM-5732
PM-5733
PM-5734
PM-5735
PM-3701
PM-3702
PM-3703

B
A
C
G
U
C
A
C
G

Protection
N-Bz
N-Bz
N-iBu
N/A
N-Ac
N-PAC
N-PAC
N-PAC

Catalog#PM-5731
PM-5732
PM-5733
PM-5734
PM-5735
PM-3701
PM-3702
PM-3703

Productname
5’-O-DMTr-2’-O-Methyl-adenosine (N-Bz) M.W.687.74
5’-O-DMTr-2’-O-Methyl-cytidine (N-Bz) M.W.683.72
5’-O-DMTr-2’-O-Methyl-guanosine (N-iBu) M.W. 669.72
5’-O-DMT-2’-O-Methyl-uridine M.W, 580.59
5’-O-DMTr-2’-O-Methyl-cytidine (N-Ac) M.W.601.65
5’-O-DMTr-2’-O-Methyl-adenosine (N-PAC) M.W. 717.77
5’-O-DMTr-2’-O-Methyl-cytidine (N-PAC) M.W. 693.74
5’-O-DMTr-2’-O-Methyl-guanosine (N-PAC) M.W. 733.77

500mg$180.00$150.00$180.00$150.00$180.00$195.00$165.00$195.00

1g$340.00$280.00$340.00$280.00$340.00$355.00$310.00$355.00

5g$1,530.00$1,260.00$1,530.00$1,260.00$1,530.00$1,590.00$1,395.00$1,590.00

Purity: Ultrapure products: Isomeric impurity undected by HPLC.

5’-O-DMTr-5-propynyl-2’-O-methyl-uridine

5’-O-DMTr-5-propynyl-2’-O-methyl-cytidine (N-Bz)

Catalog#Catalog#

O
NH
N

O

NHBz

PM-1027

N

PricingN$375.00 / 100 mg

DMTrO
O

O

Isomeric impurity
undected by HPLC.

5’-O-DMTr-5-methyl-2’-(O-Methyl) uridine

Pricing$485.00 / 100 mg

DMTrOPurity: 98% +OH OCH3
C34H34N2O8
Mol. Wt.: 598

O

PM-1129

Purity: 98% +OH OCH3
C41H39N3O8
Mol. Wt.: 701

Isomeric impurity
undected by HPLC.

5’-O-DMTr-5-methyl-2’-(O-methyl)-cytidine (N-Bz)

Catalog#Catalog#
NHBz

O
NH
N

O

PM-3706

PricingN$375.00 / 100 mg

DMTrO

PM-3705

N
O

DMTrO
O

O

Purity: 98% +OH OCH3
C32H34N2O8
Mol. Wt.: 574.6

Isomeric impurity
undected by HPLC.

Pricing$485.00 / 100 mg

Purity: 98% +OH OCH3
C39H39N3O8
Mol. Wt.: 677.

Isomeric impurity
undected by HPLC.

173

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Unprotected
Nucleosides

Nucleosides
DMT-protected
Nucleosides
DMT-protected
Nucleosides

B
DMTrO

OH OTBDMS

Catalog#PM-5851

Productname
5’-O-DMTr-2’-O-TBDMS-Adenosine (N-Bz)

PM-5852

5’-O-DMTr-2’-O-TBDMS-Cytidine (N-Bz)

Catalog#PM-5851
PM-5852
PM-5853
PM-5854
PM-5855
PM-5856
PM-5857
PM-3501
PM-3502
PM-3503
PM-5859
PM-3504
PM-5850

CAS No.
81265-93-2

81246-80-2

1g$90.005g		
$356.00

10g$675.00$90.00$356.00$675.00$90.00$555.00$845.00$90.00$356.00$675.00$98.00$451.00$845.00$95.00$555.00$845.00$95.00$555.00$845.00$90.00$380.00$700.00$90.00$380.00$700.00$93.00$388.00$705.00$93.00$388.00$705.00$93.00$388.00$705.00$93.00$388.00$705.00

Reagents

Protection
N-Bz
N-Bz
N-iBu
N/A
N/A
N-Ac
N,N-diBz
N-PAC
N-PAC
N-PAC
N-DMF
N-iPrPAC
N-Ac

DMT-protected
Nucleosides

O

B
A
C
G
U
I
C
A
A
C
G
G
G
G

N-protected
Nucleosides

DMTr Protected 2’-O-TBDMS Ribo Nucleosides

M.W.787.97

M.W.763.95

5’-O-DMTr-2’-O-TBDMS-Guanosine (N-iBu)
M.W. 769.96

PM-5854

5’-O-DMTr-2’-O-TBDMS-Uridine
M.W, 660.83

PM-5855

5’-O-DMTr-2’-O-TBDMS-Inosine

Triphosphates

PM-5853

M.W, 684.85

PM-5856

PM-3501
PM-3502
PM-3503
PM-5859
PM-3504
PM-5850NHS Esters

PM-5857

5’-O-DMTr-2’-O-TBDMS-Cytidine (N-Ac)
M.W.701.88
5’-O-DMTr-2’-O-TBDMS-Adenosine (N,N-diBz)
M.W. 892.08
5’-O-DMTr-2’-O-TBDMS-Adenosine (N-PAC)
M.W. 818.00
5’-O-DMTr-2’-O-TBDMS-Cytidine (N-PAC)
M.W. 793.98
5’-O-DMTr-2’-O-TBDMS-Guanosine (N-PAC)
M.W. 834.00
5’-O-DMTr-2’-O-TBDMS-Guanosine (N-DMF)
M.W. 754.95
5’-O-DMTr-2’-O-TBDMS-Guanosine (N-iPrPAC)
M.W. 876.08
5’-O-DMTr-2’-O-TBDMS-Guanosine (N-Ac)
M.W. 741.90

Purity: 0% Isomeric Impurity. These are Ultrapure Products.

174

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Nucleosides
DMT-protected Nucleosides
DMTr Protected 3’-O-TBDMS Nucleosides

B
DMTrO
O
TBDMSO

OH

B
A
C
G
U
C

Catalog#PM-5861

Productname
5’-O-DMTr-3’-O-TBDMS-Adenosine (N-Bz)

PM-5862

5’-O-DMTr-3’-O-TBDMS-Cytidine (N-Bz)

Protection
N-Bz
N-Bz
N-iBu
N/A
N-Ac

Catalog#PM-5861
PM-5862
PM-5863
PM-5864
PM-5866250mg$90.00500 mg$155.00

1g$320.00

5g$1,360.00$90.00$155.00$320.00$1,360.00$126.00$210.00$450.00$1,910.00$90.00$155.00$320.00$1,360.00$90.00$155.00$320.00$1,360.00

M.W.787.97

M.W.763.95

PM-58635’-O-DMTr-3’-O-TBDMS-Guanosine (N-iBu)
M.W. 769.96

PM-5864

5’-O-DMTr-3’-O-TBDMS-Uridine
M.W, 660.83

PM-5866

5’-O-DMTr-3’-O-TBDMS-Cytidine (N-Ac)
M.W, 701.88

Purity: Ultrapure Products. Isomeric impurity undected by HPLC.

175

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Phosphoramidite
Chemistry
Reagents
Phosphoramidite
Chemistry
Reagents

1H-1,2,4-Triazole

Dicyanoimidazole (DCI)CAS No. 288-88-0

Catalog#
RN-1412NN$17.00 / 25 g
$60.00 / 100 g$240.00 / 500 g

C2H3N3
Mol. Wt.: 69

Catalog#

RN-1571$15.00 / 1 g$65.00 / 5 g$180.00 / 50 g
$320.00 / 100 g$1,020.00 / 1 kg

N
H

CAS No. 93183-36-9

Mesitylene-sulphonyl-3-nitro-1H-1,2,4-Triazole (MSNT)

Pricing

NO2

Catalog#

Pricing$80.00 / 5 g$240.00 / 50 g
$420.00 / 100 g$1,050.00 / 1 kg

C7H17N5
Mol. Wt.: 171

C11H12N4O4S
Mol. Wt.: 296

Catalog#
RN-1415NH

5-Ethylthio-1H-tetrazole (ETT)Pricing$18.00 / 1 g$78.00 / 5 g$216.00 / 50 g
$354.00 / 100 g$1,020.00 / 1 kg

CAS No. 74257-00-4

N

NN

CAS No. 89797-68-2

Catalog#

Pricing

RN-6397$18.00 / 1 g$78.00 / 5 g$216.00 / 50 g
$354.00 / 100 g$1,020.00 / 1 kg

S

N
H
C3H6N4S
Mol. Wt.: 130

NHS Esters

C8H8N4S
Mol. Wt.: 192

CAS No.21871-47-6$36.00 / 1 g$120.00 / 5 g$198.00 / 10 g

Sugars5-Benzylthio-1H-tetrazole (BMT; BTT)

N
N

RN-1403NN
O S O

Reagents

RN-1413N
H2
NS

Pricing

N

N
N

N

N
NC

Catalog#

C5H2N4
Mol. Wt.: 118

Diisopropyl-ammonium-1H-tetrazolide

N

NC

CAS No. 21122-28-7

DMT-protected
Nucleosides

N
H

Pricing

N-protected
Nucleosides

Activation Reagents

Unprotected
Nucleosides

Phosphoramidite Chemistry Reagents

Bulk Quantity Available:
Bulk quantities of Ultra Pure 5’-benzylthio tetrazole & 5-Ethylthio tetrazole are available in 10, 50 & 100 kg size.
Please enquire for pricing.

5-Ethylthio-Tetrazole in RNA Synthesis

5-Ethylthio-tetrazole has been demonstrated to be a superior coupling reagent for RNA synthesis. This reagent increases the
stepwise coupling efficiency by 2-3% as compared to the conventional activator 1-H Tetrazole1 The overall yield and quality of oligonucleotide have been shown to increase dramatically when using 5-ethylthio-tetrazole. Perhaps the greater acidity and stabilityof 5-ethylhio-tetrazole accounts for its superior performance. This reagent is especially suitable for large scale RNA synthesis.
Damha et. al. have utilized this reagent in RNA synthesis of natural linkage (3’-5’) and unnatural linkage (2’- 5’) and observed
coupling efficiencies were >99% with coupling time of 7.5 min2.
1. Sproat, B.; Colonna, F.; Mullah, B.; Tsou, D.; Andrus, A.; Hampel, A.; Vinayak, R. Nucleosides & Nucleotides 1995, 14, 255.
2. Wasner, M.; Ariohn, D.; Borkow, G.; Noronha, A.; Uddin, A.; Parniak, M.; Damha, M. Biochemistry 1998, 37, 7478.

176

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Phosphoramidite
PhosphoramiditeChemistry
ChemistryReagents
Reagents
Bulk Quantities: DMTr Chloride & MMTr Chloride
DMTr-Chloride

CAS No. 40615-36-9

MMTr-Chloride

Catalog#

OMe

CAS No. 14470-28-1

OMe

RN-1401

RN-1574

Pricing
MeO

Cl

C21H19ClO2
Mol. Wt.: 338

TMTr-Chloride

Catalog#

PricingCl$15.00 / 5 g$50.00 / 25 g
$165.00 / 100 g$650.00 / 1 kg

C20H17ClO
Mol. Wt.: 308$18.00 / 5 g$55.00 / 25 g
$195.00 / 100 g$850.00 / 1 Kg

CAS No. 49757-42-8

Catalog#

OMe

RN-1491

Pricing
MeO

Cl$45.00 / 5 g$195.00 / 25 g

OMe
C22H21ClO3
Mol. Wt.: 368.

Bulk Quantity Available:
Bulk quantity of Ultra Pure DMTr-Chloride available in 5 kg, 10 kg, 50 kg & 100 kg size.
Please enquire for pricing.

DMTr Chloride: Typical Lot Analysis
Elemental Analysis: Chlorine analysis results within 1 g/mole of the theoretical value and < 0.4g variation per 100g.
Theoretical chlorine value: 35.44 g/moleObserved chlorine value: 36.42 g/mole
Color:

Off-white to faint pink, produces colorless DMTr-nucleosides.

Application:

Protecting agent in polynucleotide synthesis.

Reactivity:

1.2 Equivalents reacts to produce colorless DMTr-deoxynucleosides quantitatively.

177

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Phosphoramidite
Chemistry
Reagents
Phosphoramidite
Chemistry
Reagents

Phenylacetyl-disulfide (PADS)

CAS No. 15088-78-5

Silanized-Bottle (for Beaucage Reagent)

Catalog#

Pricing

RN-1496$26.50 / 5 g$108.00 / 25 gOSSCatalog#

Pricing

BL-1536$8.00 / 100 ml$8.00 / 250 ml$8.00 / 500 ml

C16H14O2S2
Mol. Wt.: 302.41

DDTT Sulfurizing reagent*

Beaucage sulfurizing Reagent

CAS No. 1192027-04-5((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazoline-3-thione

DMT-protected
Nucleosides

O

N-protected
Nucleosides

Sulfurizing Reagents

Unprotected
Nucleosides

Phosphoramidite Chemistry Reagents

CAS No. 66304-01-6

3H-1,2-Benzodithiol-3-one-1,1-dioxide

Catalog#

N

N

N

PricingS

S S
C5H7N3S3
Mol. Wt.: 205.

S

$30.00 / 1 g$150.00 / 5 g$550.00 / 25 g
$1800.00 / 100 g
1 kg / Please inquireSOO
C7H4O3S2
Mol. Wt.: 200

Catalog#

Reagents

O

RN-1588

RN-1535

Pricing$15.00 / 100 mg$50.00 / 1 g$90.00 / 2 g
Sugars*DDTT [((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazoline-3-thione/Sulfurizing Reagent]1: The use of DDTT2-4 in the

Table1: Recommended formulations for the synthesis of phosphorothioate oligonucleotides (DNA/RNA) & sulfurising in solution
phase.
Conc. of DDTT

Solvent formulation v/v5 Oxidation time ( DNA)

Comments6

0.05 M

Py/ACN – 3:7
Py/THF – 2:8

2.5 minFormulation used in solid phase deoxy oligonucleotide (DNA)synthesis

0.1 M

Py
Py/THF** – 4:6

2.0 minFormulation used in solid phase deoxy oligonucleotide(DNA)synthesis

0.05 M

Pyr/ACN -4:6

2.0 minFormulation used in solution phase deoxy oligonucleotide synthesis

0.05 M

Py/ ACN-3:7

Oxidation time (RNA)
4.0 minFormulation used in solid phase RNA synthesis

0. 1 M

Py/ACN-3:7

3 min

Formulation used in solid phase RNA synthesis

References:
1. DDTT Sulfurizing solutions are listed on Ancillary Reagents Section, Page No. 19-25.
2. Xu, Q.; Musier-Forsyth, K.; Hammer R. P.; Barany G. Nucl. Acids Res. 1996, 24, 1602.
3. Xu, Q.; Barany G.; Hammer R. P.; Forsyth, M.K. Nucl. Acids Res. 1996, 24, 3643.
4. Guzaev, A. P. et. al. U.S. Pat. Number 7,723,528.
5. For use of THF, care must be taken to ensure peroxide free THF only.
6. (>99%) to P-S and negligible amount of P-O formation occurred, as analyzed by 31P NMR.

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178

NHS Esters

sulfurization step of oligonucleotide synthesis results in a very high percentage of sulfurization. In DNA synthesis, less than 2% of PO
linkages in mixed-base oligodeoxynucleotide phosphorothioates were observed. In RNA synthesis, most sulfuriation agents including
Beaucage Reagent are often inefficient. In contrast, the use of DDTT results typically only in 6-8% of the PO contents. It has further
advantage of greater stability in the formulated solutions (upto six months). Recommended formulations are summarized in the tablebelow (Table 1).

Phosphoramidite
Chemistry Reagents
Phosphoramidite
Chemistry Reagents
Phosphorylating Reagents
Methyl dichlorophosphite

2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Methyl phosphorodichloridite

CAS No. 89992-70-1

Catalog#

Pricing

RN-1407$18.00 / 1 g$30.00 / 5 g$85.00 / 25 g

Catalog#

Pricing

RN-1505$13.50 / 1 g$55.50 / 5 g$250.00 / 25 g
$700.00 / 100 g

Cl
MeO

P
Cl

CH3Cl2OP
Mol. Wt.: 132

CAS No. 3279-26-3

Bis(diisopropylamino)-chlorophosphineN

Pricing

RN-8882$15.00 / 1 g$70.00 / 5 g$900.00 / 100 g

RN-8883$16.00 / 1 g$75.00 / 5 g

CAS No. 56183-63-2

CAS No. 76101-30-9

Catalog#

Pricing

RN-8881$20.00 / 1 g$95.00 / 5 g

OMe

C13H31N2OP
Mol. Wt.: 262

2-Cyanoethyl N,N,N’,N’-tetraisopropylphosphordiamidite

N

CAS No. 92611-10-4

Pricing

RN-1510$265.00 / 5 g$2,120.00 / 50 g

P
Cl
C7H17ClNP
Mol. Wt.: 181

Pricing

RN-1545$12.00 / 1 g$40.00 / 5 g$550.00 / 100 g

O

C15H32N3OP
Mol. W.t: 301.41

Catalog#Catalog#
CN

P
N

Chloro-N,N-diisopropyl-1-methylphosphinamine

N

C9H18ClN2OP
Mol. Wt.: 236.6

Catalog#PN

CN

2-Cyanoethyl dichlorophosphite

Methyl N,N,N’,N’-tetraisopropylphosphordiamidite

N

P
Cl

PricingCl

C12H28ClN2P
Mol. Wt.: 266

O

Catalog#PNN

CAS No. 102691-36-1

Diethyl diisopropylphosphoramidite

OEt
P
OEt
C10H24NO2P
Mol. Wt.: 221

Catalog#

Pricing

RN-1410$90.00 / 5 g

N

CAS No. 42053-26-9Ethylene-glycol-morpholino phosphoramidite(4-(1,3,2-dioxaphospholan-2-yl)morpholine)

O

O
P
N

Catalog#

Pricing

RN-1516$20.00 / 1 g$95.00 / 5 gdiethyl diisopropylphosphoramidite (RN-1410): A stable capping Reagent
This reagent is utilized for capping directly during oligodeoxynucleotide synthesis byphosphoramidite method and avoids preparation of the commonly used, and rather
unstable, Diethylphosphotriazolide capping reagent.

O
C6H12NO3P
Mol. Wt.: 177

Ethylene-glycol-morpholino phosphoramidite (RN-1516)
Ethylene-glycol-morpholino phosphoramidite an exicileent capping reagent.

179

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Unprotected
Nucleosides

Phosphoramidite Chemistry Reagents
Phosphoramidite
Chemistry Reagents
Phosphoramidite
Chemistry Reagents

Methyl N,N’-diisopropylchlorophosphoramidite
Catalog#

Cl

MeO
P
N

Pricing

RN-1409

Ethyl N,N’-diisopropylchlorophosphoramiditeCl

EtO

Catalog#

Pricing

RN-4137$40.00 / 1 g$190.00 / 5 g

C8H19ClNOP
Mol. Wt.: 211

O
P
Cl
O
Cl

Catalog#

Pricing

RN-1421$18.50 / 5 g$74.00 / 25 g

Cl
C6H4Cl3O2P
Mol. Wt.: 245

CAS No. 15074-54-1

Diethyl phosphorochloridite
OEt
Cl P

Catalog#

Pricing

RN-1408$30.00 / 5 g$99.00 / 25 g

OEt
C4H10ClO2P
Mol. Wt.: 156

Reagents

P
N

2-Chlorophenyl-phosphorodichloridate

DMT-protected
Nucleosides

C7H17ClNOP
Mol. Wt.: 197$17.00 / 1 g$60.00 / 5 g$264.00 / 25 g
$816.00 / 100 g
CAS No. 86030-43-5

N-protected
Nucleosides

Phosphorylating Reagents & Bis-Silyloxy Reagents

CAS No. 589-57-1

Nucleoside synthesis ReagentsCl
O

Catalog#

Pricing

RN-1705$15.00 / 1 g$70.00 / 5 g

O

CAS No. 223128-33-4(1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane)

Si

Cl
O
Cl
Si

Catalog#

Pricing

RN-1521$40.00 / 1 g$80.00 / 5 g$210.00 / 50 g

C12H28Cl2OSi2
Mol. Wt.: 315

NHS Esters

C11H13ClO2
Mol. Wt.: 212

Bis-silylating Reagent; TIPS chloride

Sugars4-Isopropyl-phenoxy-acetylchloride (iPrPAC-Cl)

CAS No. 69304-37-6

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Nucleosides & Reagents
Phosphoramidite Chemistry Reagents
Sugars, Purines & Pyrimidines
2,3,5-Tri-O-benzoyl-β-D-ribofuranosyl-1-Acetate
BzO

OAc
O

Catalog#

Pricing

RN-4131

OBz OBz
C28H24O9
Mol. Wt.: 504

ON

C5H3ClN4
Mol. Wt.: 154

C21H21O5
Mol. Wt.: 388.

Catalog#

Pricing

RN-1030$20.00 / 1 g$68.00 / 5 g

Cl

H2N

CAS No. 84955-31-7

2-Deoxy-D-ribose
H
OH
OH
CH2OH

2-Deoxy-β-L-ribose

Catalog#
Pricing$16.00 / 1 g$52.00 / 5 g
Purity: 98% +C5H10O4
Mol. Wt.: 134

AcO
O

OAc

CAS No. 3680-69-1

Purity: 98% +CAS No. 18546-37-7

Catalog#

HO

RP-1062

H
H
H
CH2OH

Pricing$16.00 / 1 g$52.00 / 5 g
Purity: 98% +

1,3,5-O-Triacetyl 2-deoxy-a/β-L-ribose

Catalog#

Pricing

RN-1064$44.00 / 5 g$150.00 / 25 g

OAc
C11H16O7
Mol. Wt.: 260.2

CAS No. 10310-21-1

H
HO
HO

C5H10O4
Mol. Wt.: 134

1,3,5-O-Triacetyl 2-deoxy-a/β-D-ribose$40.00 / 1 g$190.00 / 5 g$138.00 / 1 g

C6H4ClN3
Mol. Wt.: 153

RN-1061

RN-1051

PricingN
HN

CAS No. 533-67-5

Pricing

RP-1021N

Purity: 98% +Catalog#Catalog#Cl$138.00 / 1 g

N
H

C6H5ClN4
Mol. Wt.: 168.5

H
H
H

CAS No. 4330-21-6

6-Chloro-7-deaza-purine

PricingO$45.00 / 1 g$200.00 / 5 gNHN

C5H4ClN5
Mol. Wt.: 169

CAS No. 87-42-3

BS-1011N

N

N

Catalog#Cl

H

RN-4130ClCAS No. 6974-32-9

6-Chloro-7-deaza-guanineN

Pricing

OTol

N
H

H2N

Catalog#

6-Chloro-guanine

Cl

N

TolO

$32.00 / 5 g$122.00 / 25 g

6-Chloro-purineN1-α-chloro-3,5-ditoluoyl-2-deoxy-D-ribose

OAc
AcO

O

Catalog#

Pricing

RN-1065$45.00 / 1 g$200.00 / 5 g

OAc
C11H16O7
Mol. Wt.: 260.24

CAS No. 4594-52-9

1-Methoxy-2,3,5-O-tribenzoyl-a/β-D-ribose
BzO
O

OMe

BzO BzO

Catalog#

Pricing

RN-1031$20.00 / 1 g$80.00 / 5 g

C27H24O8
Mol. Wt.: 476.47

181

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5 & 6 Fluorescein
NHS Esters NHS Esters
5 & 6 Fluorescein

5-Fluorescein-dipivalate NHS Ester

6-Fluorescein-dipivalate NHS Ester(5-FAM-Dipivalate NHS Ester)(6-FAM-Dipivalate NHS Ester)

Catalog#
O

O

O

O
O

O

O

O

RN-9652

O

O

O

PricingO$67.00 / 10 mg$303.75 / 50 mg$545.00 / 100 mg

O
O
O
N

O

$74.25 / 10 mg$334.00 / 50 mg$601.00 / 100 mg

O

Purity: 98% +Reagents

C35H31NO11
Mol. Wt.: 641.62

C35H31NO11
Mol. Wt.: 641.62

6-Fluorescein NHS Ester

CAS No. 92557-81-8(6-FAM NHS Ester)

Catalog#O

OON

PricingO

Purity: 98% +O

HOCatalog#O

DMT-protected
Nucleosides

RN-9651
O

N-protected
Nucleosides

NHS Esters: Fluoresceins

O
O
O
N

C25H15NO9
Mol. Wt.: 473.39

CAS No. 92557-80-7(5-FAM NHS Ester)

HO

O

O

RN-9661

Catalog#
RN-9662

CO2H

Pricing$22.00 / 10 mg$144.00 / 100 mg$1,296.00 / 1 g

Purity: 98% +Pricing
O

O
N

O

O

$24.75 / 10 mg$178.50 / 100 mg$1,606.00 / 1 g

NHS EstersO

5-Fluorescein NHS Ester

SugarsCO2H

Unprotected
Nucleosides

NHS Esters

Purity: 98% +C25H15NO9
Mol. Wt.: 473.3

182

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Monophosphates
Nucleosides& Reagents
Biotin NHS Esters

Sugars & Purines for Synthesis

NHS Esters: Biotin
CAS No. 72040-63-2(+) Biotin-Amido-hexanoic acid NHS ester
O
HN
O
O
O

Pricing

RN-1449$56.00 / 25 mg$168.00 / 100 mg$348.00 / 250 mg

S

N
H

N

Catalog#
H

H

O

O

NH

4

C20H30N4O6S
Mol. Wt.: 454.54(+) Biotin N-hydroxysuccinimido ester; d-Biotin NHS-ester
O
O
O

HN
H

NH
H

Pricing

RN-1500$68.00 / 100 mg$186.00 / 250 mg$426.00 / 1 g

NO

CAS No. 35013-72-0

Catalog#S

4
C14H19N3O5S
Mol. Wt.: 341

O(+) Biotin-X-Y-SSE (Biotinamidohexanoyl-amidobutanoyl Succinimidyl ester)
O
HN

NH

O

Catalog#

Pricing

RN-1508$30.00 / 100 mg

O
H
N

O N
N
H

S
O

O

O

C24H37N5O7S
Mol. Wt.: 539.65

183

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Unprotected
Nucleosides

Monophosphates

NH2
N

Pricing

NMP-8311$165.00 / 1 mg
$297.00 / 2 mg
$667.00 / 5 mg

ONO
HO P OOH

Catalog#

O

Purity: 98% +

OCH3

OH

N-protected
Nucleosides

2’-O-Methyl-cytidine-5’-monophosphate (Sodium salt)

DMT-protected
Nucleosides

C10H16N3O8P (Free Monophosphat
Mol. Wt.: 337.22

2’-O-Methyl-guanosine-5’-monophosphate (Sodium salt)
O
N

NH

N

Catalog#

Pricing

NMP-8312$165.00 / 1 mg
$297.00 / 2 mg
$667.00 / 5 mg

NH2

N

O
OH

ReagentsO
HO P OOH

CAS No. 24121-01-5

Purity: 98% +OCH3

C11H16N5O8P (Free Monophosphat
Mol. Wt.: 377.25

2’-O-Methyl-N6-benzyl-adenosine-5’-monophosphate (Sodium salt)
Pricing

NMP-8313$165.00 / 1 mg
$297.00 / 2 mg
$667.00 / 5 mg

NHS Esters

Catalog#
HN
N

N

N

O
HO P O
OH

N

O
OH

Purity: 98% +OCH3

Monophosphates

C18H22N5O7P (Free Monophosphat
Mol. Wt.: 451.37

ß-L-Adenosine-5’-monophosphate (Sodium salt)
NH2
N

N

N

NMP-8314$200.00 / 1 mg
$360.00 / 2 mg
$810.00 / 5 mg

O

Diphosphates

PricingO
O P OHOH

N

OH

Catalog#

Purity: 98% +OH

C10H14N5O7P (Free Monophospha
Mol. Wt: 347.22

ß-L-Uridine-5’-monophosphate (Sodium salt)
O

NO

Pricing

NMP-8315$200.00 / 1 mg
$360.00 / 2 mg
$810.00 / 5 mg

O
O P OHOH

OOH

Catalog#

OH

Triphosphates

NH

Purity: 98% +C9H13N2O9P (Free Monophosphat
Mol. Wt.: 324.18

184

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Monophosphates
Monophosphates
3’-Amino-guanosine-5’-monophosphateONO
HO P O
OH

NH

N

N

Catalog#

Pricing

NMP-8316$200.00 / 1 mg
$360.00 / 2 mg
$810.00 / 5 mg

NH2O

NH2 OHC10H15N6O7P (Free Monophospha
Mol. Wt.: 362.24

Purity: 98% +Ethano-cytidine-5’-monophosphate
N
N

Pricing

NMP-8317$200.00 / 1 mg
$360.00 / 2 mg
$810.00 / 5 mg

ONO
HO P OOH

Catalog#

O

Purity: 98% +OH

OH

C11H14N3O8P (Free Monophosphat
Mol. Wt.: 347.22

Iso-guanosine - 5’-monophosphate
Catalog#

Pricing

NMP-8318$200.00 / 1 mg
$360.00 / 2 mg
$810.00 / 5 mg

Purity: 98% +3’-Methyl-guanosine-5’-monophosphate
O
N

NH

N

O
HO P OOHN

Catalog#

Pricing

NMP-8319$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

NH2

O

Purity: 98% +OMe OHC11H16N5O8P (Free Monophosphat
Mol. Wt.: 377.25

Ribo-Thymidine-5’-monophosphate
O
NH
N

O
HO P OOHOCatalog#

Pricing

NMP-8319$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

O
OH

OH

Purity: 98% +C10H15N2O9P (Free Monophosphat
Mol. Wt.: 338.21

185

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Unprotected
Nucleosides

diphosphates
Monophosphates

NH
NO
HO P OOH

N

N

Catalog#

Pricing

NMP-8431$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

NO

N-protected
Nucleosides

N1-Methyl-2’-deoxyadenosine-5’-monophosphate (Sodium salt)

DMT-protected
Nucleosides

Purity: 98% +OH
C11H16N5O6P (Free Monophosphat
Mol. Wt.: 345.25

N3-Methyl-2’-deoxycytidine-5’-monophosphate (Sodium salt)
Catalog#

Pricing

NMP-8432$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

NH
N
N

O

O

OH
C10H16N3O7P (Free Monophospha
Mol. Wt.: 321.22

ReagentsO
HO P O
OH

Purity: 98% +N6-Methyl-2’-deoxyadenosine-5’-monophosphate (Sodium salt)
Pricing

NMP-8433$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

NHS Esters

Catalog#
HNNO
HO P O
OH

N

N

N

O

Purity: 98% +OH

Monophosphates

C11H16N5O6P (Free Monophospha
Mol. Wt.: 345.25

Ethano-2’-deoxycytidine-5’-monophosphate (Sodium salt)
Catalog#

Pricing

NMP-8434$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

N
N
N

O

O

OH
C11H14N3O7P (Free Monophosphat
Mol. Wt.: 331.22

Diphosphates

O
HO P O
OH

Purity: 98% +7-Deaza-2’-deoxyadenosine-5’-monophosphate;2’-Deoxytubercidin-5’-monophosphate (Sodium salt)

NO
HO P OOHN

Catalog#

Pricing

NMP-8435$200.00 / 1 mg
$360.00 / 2 mg
$810.00 / 5 mg

NO

Triphosphates

NH2

Purity: 98% +OH
C11H15N4O6P (Free Monophosphat
Mol. Wt.: 330.23

186

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Monophosphates
Triphosphates
3’,5’-Diphosphates and 5’-diphosphates2’-O-Methyl-adenosine-3’,5’-diphosphate (Sodium salt)
NH2
N
N

O
HO P OOH

Catalog#

Pricing

NDP-7311$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

N
N

O

O
OMe
HO P O
OH

Purity: 98% +C11H16N5O10P2(Free diphospha
Mol. Wt.: 441.23

2’-O-Methyl-cytidine-3’,5’-Diphosphate (Sodium salt)
NH2
N
O

N

O
HO P OOH

Catalog#

Pricing

NDP-7312$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

O

Purity: 98% +

OMe
O
P O
OH

OH

C10H17N3O11P2(Free diphospha
Mol. Wt.: 417.20

2’-O-Methyl-guanosine-3’,5’-Diphosphate (Sodium salt)
ONO
HO P O
OH

NH

N

N

NH2

Catalog#

Pricing

NDP-7313$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

O

OH

OCH3
O
P O
OH

Purity: 98% +C11H17N5O11P2 (Free disphosphat
Mol. Wt.: 457.22

2’-O-Methyl-uridine-3’,5’-Diphosphate (Sodium salt)
O

Catalog#

Pricing

NDP-7314$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

NHO
HO P O
OH

OH

N

O

O
OCH3
O
P O
OH

Purity: 98% +C10H16N2O12P2 (Free disphosphMol. Wt.: 418.19

Uridine-5’-diphosphate (Sodium salt)[NDP-7315]

CAS No. 21931-53-3
O
NH

O
O
HO P O P O
OH
OH

N

O

Uridine 5’-diphosphate (Sodium salt) Hydrate[NDP-7316]

Catalog#

Pricing

NDP-7315
NDP-7316$165.00 / 1 mg
$297.00 / 2 mg
$669.00 / 5 mg

O
OH

OH

Purity: 98% +C9H14N2O12P2(Free Diphospha
Mol. Wt.: 404.16

187

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Unprotected
Nucleosides

Triphosphates
N-protected
Nucleosides

2’-O-Methyl-adenosine-5’-triphosphate (Sodium salt)
NH2
N

N

N

Pricing

NTP-3386$240.00 / 1 mg
$430.00 / 2 mg
$970.00 / 5 mg

NO

Purity: 98% +OH

DMT-protected
Nucleosides

OOO
HO P O P O P O
OH
OH
OH

Catalog#

OMe

C11H18N5O13P3 (Free Triphosphat
Mol Wt.: 521.21

2’-O-Methyl-cytidine-5’-triphosphate (Sodium salt)
NH2
NO

Pricing

NTP-3387$240.00 / 1 mg
$430.00 / 2 mg
$970.00 / 5 mg

O
OH

ReagentsN

O
OO
HO P O P O P O
OH
OH
OH

Catalog#

Purity: 98% +OMe

C10H18N3O14P3 (Free Triphosphat
Mol. Wt.: 497.18

2’-O-Methyl-guanosine-5’-triphosphate (Sodium salt)

N

O
O
O
HO P O P O P O
OH
OH
OH

NH
N

Catalog#

Pricing

NTP-3388$240.00 / 1 mg
$430.00 / 2 mg
$970.00 / 5 mg

NH2

O

Purity: 98% +OMeMonophosphates

OH

NHS EstersO
N

C11H18N5O14P3 (Free Triphosphate)
Mol. Wt.: 537.21

2’-O-Methyl-uridine-5’-triphosphate (Sodium salt)
O
NH

Pricing

NTP-3389$240.00 / 1 mg
$430.00 / 2 mg
$970.00 / 5 mg

O

Diphosphates

N

O
O
O
HO P O P O P O
OH
OH
OH

Catalog#

O

Purity: 98% +OH

OMe

C10H17N2O15P3 (Free Triphosphat
Mol. Wt.: 498.17

Iso-guanosine-5’-triphosphate (Sodium salt)

N

O
O
O
HO P O P O P O
OH
OH
OH

NH
N

Pricing

NTP-4348$280.00 / 1 mg
$500.00 / 2 mg
$1125.00 / 5 mg

O

O
OH

Catalog#

Triphosphates

NH2
N

Purity: 98% +OH

C10H16N5O14P3 (Free Triphosphate)
Mol. Wt.: 523.18

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Triphosphates
Triphosphates
Etheno-2’-deoxyadenosine-5’-triphosphate (Sodium salt)
N
N

N

N

O
O
O
HO P O P O P O
OH
OH
OH

Catalog#

Pricing

NTP-4344$280.00 / 1 mg
$500.00 / 2 mg
$1125.00 / 5 mg

NO

Purity: 98% +OH

C12H16N5O12P3 (Free Triphospha
Mol. Wt.: 515.20

Etheno-2’-deoxycytidine-5’-triphosphate (Sodium salt)
N
N
N

O
O
O
HO P O P O P O
OH
OH
OH

Catalog#

Pricing

NTP-4346$280.00 / 1 mg
$500.00 / 2 mg
$1125.00 / 5 mg

OO

Purity: 98% +OH
C11H16N3O13P3 (Free Triphospha
Mol. Wt.: 491.18

7-Deaza-2’-deoxyadenosine-5’-triphosphate (Sodium salt)
NH2
N
N

O
O
O
HO P O P O P O
OH
OH
OH

Catalog#

Pricing

NTP-4384$240.00 / 1 mg
$430.00 / 2 mg
$970.00 / 5 mg

NO

Purity: 98% +OH
C11H17N4O12P3 (Free Triphosphate)
Mol. Wt.: 490.19

CAS No. 101515-08-6

7-Deaza-2’-deoxyguanosine-5’-triphosphate (Sodium salt)
O
NH
N

O
O
O
HO P O P O P O
OH
OH
OH

N

Catalog#

Pricing

NTP-4386$240.00 / 1 mg
$430.00 / 2 mg
$970.00 / 5 mg

NH2

O

Purity: 98% +OH

C11H17N4O13P3 (Free Triphosphate)
Mol. Wt.: 506.19

Iso-2’-deoxyguanosine-5’-triphosphate (Sodium salt)
NH2
N
N

O
O
O
HO P O P O P O
OH
OH
OH

N
N
H

Catalog#

Pricing

NTP-4396$280.00 / 1 mg
$500.00 / 2 mg
$1125.00 / 5 mg

OO

Purity: 98% +OH

189

C10H16N5O13P3 (Free Triphosphate
Molecular Weight: 507.18

Toll Free: (800) 762-9323
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Unprotected
Nucleosides

Triphosphates
N-protected
Nucleosides

Ara Triphosphate (Sodium salt)
OOOHO P O P O P O
OH
OH
OH

B
O

B
A		
C		
G		
U		

Catalog#
NTP-5411
NTP-5412
NTP-5413
NTP-5414

DMT-protected
Nucleosides

OH

5’
Triphosphate 		Triphosphate 		Triphosphate 		Triphosphate 		OH
Catalog#
NTP-5411
NTP-5412
NTP-5413
NTP-5414

Product Name
Ara-adenosine M.W. 551.14
Ara-cytidine M.W. 527.12
Ara-guanosine M.W. 567.14
Ara-uridine M.W. 528.10

1mg$300.00$300.00$300.00$300.00

2mg$540.00$540.00$540.00$540.00

5mg$1,215.00$1,215.00$1,215.00$1,215.00

Reagents

Purity: All the above produced have a purity of 98% +Ara 2’-O-Methyl Triphosphate (Sodium salt)

B
O
OMe

5’
Triphosphate 		Triphosphate 		Triphosphate 		Triphosphate 		

B
A		
C		
G		
U		

1mg
$350.00$350.00$350.00$350.00

2mg$630.00$630.00$630.00$630.00

Catalog#
NTP-5311
NTP-5312
NTP-5313
NTP-5314

NHS EstersOOOHO P O P O P O
OH
OH
OH
OH

Product NameAra-(2’-O-Methyl)-adenosine M.W. 565.17
Ara-(2’-O-Methyl)-cytidine M.W. 541.15
Ara-(2’-O-Methyl)-guanosine M.W. 581.17
Ara-(2’-O-Methyl)-uridine M.W. 542.13

5mg$1,410.00$1,410.00$1,410.00$1,410.00

Monophosphates

Catalog#
NTP-5311
NTP-5312
NTP-5313
NTP-5314

Purity: All the above produced have a purity of 98% +Diphosphates
Triphosphates

190

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Triphosphates
Triphosphates
7-Deaza-7-propargylamine-2’,3’-dideoxyadenosine-5’-triphosphate-(NTP-6311)
7-Deaza7-propargylamine-2’,3’-dideoxydenosine-5’-triphosphate (Sodium salt) (NTP-6312)
H2N
NH2
N
N

O
O
O
HO P O P O P O
OH
OH
OH

Catalog#

Pricing

NTP-6311
NTP-6312$300.00 / 1 mg
$540.00 / 2 mg
$1,215.00 / 5 mg

N

Purity: 98% +O

C14H20N5O11P3 (Free Triphosphate)
Mol. Wt.: 527.26

7-Deaza-7-propargylamine-2’,3’-dideoxyguanosine-5’-triphosphate (Sodium salt)
H2N
O

Catalog#

Pricing

NTP-6313$300.00 / 1 mg
$540.00 / 2 mg
$1,215.00 / 5 mg

NH
N

O
O
O
HO P O P O P O
OH
OH
OH

NH2

N

Purity: 98% +O

C14H20N5O12P3(Free Triphosphate)
Mol. Wt.: 543.26

2’,3’-Dideoxyguanosine-5’-triphosphate (Sodium salt)

CAS No. 68726-28-3

Catalog#

Pricing

NTP-6316$280.00 / 1 mg
$500.00 / 2 mg
$1,125.00 / 5 mg

O
N
O
O
O
HO P O P O P O
OH
OH
OH

N

NH
NH2

N

O

Purity: 98% +C10H16N5O12P3 (Free Triphosphate)
Mol. Wt.: 491.18

5-Propargylamine-2’, 3’-dideoxycytidine-5’-triphosphate (Sodium salt) (NTP-5316)
5-Propargylamine-2’, 3’-dideoxycytidine-5’-triphosphate (NTP-5318)
NH2

H 2N

N
N
O
O
O
HO P O P O P O
OH
OH
OH

O

O

Catalog#

Pricing

NTP-5316
NTP-5318$300.00 / 1 mg
$540.00 / 2 mg
$1,215.00 / 5 mg

Purity: 98% +C12H19N4O12P3 (Free Triphosphate
Mol. Wt.: 504.22

5-Propargylamine-2’,3’-dideoxy-uridine-5’-triphosphate (Sodium salt)
O

H2N

NH
N
O
O
O
HO P O P O P O
OH
OH
OH

191

Catalog#

Pricing

NTP-5317$300.00 / 1 mg
$540.00 / 2 mg
$1,215.00 / 5 mg

OO

Purity: 98% +C12H18N3O13P3 (Free Triphosphat
Mol. Wt.: 505.20

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

Common Abbreviations
Common Abbreviations
DBF
Di-N-butylformamidyl

Ac
AcetylBz
BenzoylCE
Cyanoethyl

DMF
Dimethylformamidyl

iBu
isobutyryl

TBDMS
tertbutyldimethylsilyl

2-(2-Nitrophenyl) propoxycorbonyl

TEA
triethylammonium

TFA
Trifluoracetyl

TOM[(triisopropylsilyl)oxy]methyl

iPrPAC
Isopropyl-phenoxyacetyl

ALE
Acetal Levulinyl ester

Pivom
Pivaloyloxymethyl

Ph-Ac
Phenyl Acetyl

Bis Silyl
Tetra-isopropyl-disiloxane

NPPOC

O
O

O
O
C6H9O4
Mol. Wt.: 145.

192

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INDEX-1: Common Name
Triphosphates
DMTr
Dimethoxytrityl

Fmoc
Fluorenylmethoxycarbonyl

TMTr
Trimethoxytrityl

MMTr
Monoimethoxytrityl

PAC
Phenoxyacetyl

tBPAC
tert-butylphenoxyacetyl

CEP
Cyanoethyl N,N’-diisopropyl
phosphoramidite

Levulinyl
THF-tetrahydrofuran
lcaa= long chain allkylamino
CPG=Control Pore Glass
AMA=ammonium methyl amine(aq)193Toll Free: (800) 762-9323
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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

Deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-5551

3

Deoxyadenosine (N-Bz)-MMTr-3'-CEP

ANP-5556

3

Deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-5560

3

Deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-5552

3

Deoxycytidine (N-Bz)-MMTr-3'-CEP

ANP-5558

3

Deoxycytidine (N-iBu)-DMTr-3'-CEP

ANP-5559

3

Deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-5553

3

Deoxyguanosine (N-iBu)-MMTr-3'-CEP

ANP-5557

Mix bases (equimolar) (dA+dC+dG+dT)

ANP-1070

3

Thymidine-DMTr-3'-CEP

ANP-5554

3

Thymidine-MMTr-3'-CEP

ANP-5561

3

DNA Synthesis
A: CE Phosphoramidites(1)-Std base protection (DNA Synthesis)(2)-Mild base protection (DNA Synthesis)
ANP-6767

5

6

Deoxyadenosine (N -DMA)-DMTr-3'-CEP

ANP-6565

5

Deoxyadenosine (N-PAC)-DMTr-3'-CEP

ANP-6661

5

Deoxyadenosine (N6-diBz)-DMTr-3'-CEP

Deoxyadenosine (N-PAC)-MMTr-3'-CEP

ANP-5116

5

Deoxyadenosine (N-tBPAC)-DMTr-3'-CEP

ANP-5569

5

Deoxycytidine (N-PAC)-DMTr-3'-CEP

ANP-6662

5

Deoxyguanosine (N-DMF)-DMTr-3'-CEP

ANP-6769

5

Deoxyguanosine (N-iPr-PAC)-DMTr-3'-CEP

ANP-5568

5

Deoxyguanosine (N-PAC)-MMTr-3'-CEP

ANP-5118

5
5

Deoxyguanosine (N-phenyl acetyl)-DMTr-3'-CEP

ANP-5518

Deoxyguanosine (N-tBPAC)-DMTr-3'-CEP

ANP-5668

5

Deoxyguanosine (N-tBPAC)-MMTr-3'-CEP

ANP-5117

5

Thymidine-DMTr-3'-CEP

ANP-5554

5

Deoxyadenosine (N-PAC)-DMTr-3'-CEP

ANP-6661

7

Deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-5560

7

Deoxyguanosine (N-tBPAC)-DMTr-3'-CEP

ANP-5668

7

Thymidine-DMTr-3'-CEP

ANP-5554

7

ANP-7771

7

Deoxycytidine-DMTr-3'-CEP

ANP-7772

7

Deoxyguanosine-DMTr-3'-CEP

ANP-7773

712(3)-Fast base protection (DNA Synthesis)(4)-Base unprotected Phosphoramidites (DNA Synthesis)
Deoxyadenosine-DMTr-3'-CEP(5)-5'-O-Levulinyl Phosphoramidites (DNA Synthesis)5'-O-Levulinyl-deoxyadenosine (N-Bz)-3'-CEP

ANP-5001

5'-O-Levulinyl-deoxycytidine (N-Bz)-3'-CEP

ANP-5002

125'-O-Levulinyl-deoxyguanosine (N-iBu)-3'-CEP

ANP-5003

125'-O-Levulinyl-Thymidine-3'-CEP

ANP-5004

12

Deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-5101-05/10/20

4

Deoxycytidine (N-Ac)-DMTr-3'-Icaa CPG

N-5212-05/10/20

4

B: Supports(1)-3'-CPG (std base protection) (DNA Synthesis)

194

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

Deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

N-5102-05/10/20

4

Deoxycytidine (N-iBu)-DMTr-3'-Icaa CPG

N-5112-05/10/20

4

Deoxyguanosine (N-DMF)-DMTr-3'-Icaa CPG

N-9898-05/10/20

4

Deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-5103-05/10/20

4

Thymidine-DMTr-3'-Icaa CPG

N-5104-05/10/20

4

Deoxyadenosine (N-PAC)-DMTr-3'-Icaa CPG

N-P5101-05/10/20

6

Deoxycytidine (N-PAC)-DMTr-3'-Icaa CPG

N-P5102-05/10/20

6

Deoxyguanosine (N-iPrPAC)-DMTr-3'-Icaa CPG

N-P5106-05/10/20

6

Deoxyguanosine (N-PAC)-DMTr-3'-Icaa CPG

N-P5103-05/10/20

6

Thymidine-DMTr-3'-Icaa CPG

N-P5104-05/10/20

6

Deoxyadenosine (N-Bz)-DMTr- 3'-succinyl Polystyrene Support

N-7511-03

15

Deoxycytidine (N-Ac)-DMTr-3'-succinyl Polystyrene Support

N-7515-03

15

Deoxycytidine (N-Bz)-DMTr-3'-succinyl Polystyrene Support

N-7512-03

15

Deoxyguanosine (N-iBu)-DMTr-3'-succinyl PolystyreneSupport

N-7513-03

15

Thymidine-DMTr-3'-succinyl Polystyrene Support

N-7514-03

15

Deoxyadenosine (N-Bz)-DMTr-3'-non-clevable long chain spacer

N-7521-15/60/10-60

16

Deoxycytidine (N-Bz)-DMTr-3'-non-clevable long chain spacer

N-7522-15/60/10-60

16

Deoxyguanosine (N-iBu)-DMTr-3'-non-clevable long chain spacer

N-7523-15/60/10-60

16

Polystyrene non Cleavable Spacer

N-4545-03/10

16

Thymidine-DMTr-3'-non-clevable long chain spacer

N-7524-15/60/10-60

16

Deoxyadenosine (N-PAC)-DMTr-3'-oxalyl Icaa CPG

N-5131-05

104

Deoxycytidine (N-PAC)-DMTr-3'-oxalyl Icaa CPG

N-5132-05

104

Deoxyguanosine (N-PAC)-DMTr-3'-oxalyl Icaa CPG

N-5133-05

104

Thymidine-DMTr-3'-oxalyl Icaa CPG

N-5134-05

104

N-5100-05/10

18

UnyLinker Icaa CPG

N-4000-05/10/20

17

UnyLinker Microarray Slides

N-4501

17

UnyLinker Polymeric Support

N-4000-03

17

Deoxyadenosine (N-Bz)-DMTr-5'-CEP

ANP-4671

10

Deoxyadenosine (N-PAC)-DMTr-5'-CEP

ANP-4681

10

Deoxycytidine (N-Ac)-DMTr-5'-CEP

ANP-4675

10

Deoxycytidine (N-Bz)-DMTr-5'-CEP

ANP-4672

10

Deoxyguanosine (N-DMF)-DMTr-5'-CEP

ANP-4678

10

Deoxyguanosine (N-iBu)-DMTr-5'-CEP

ANP-4673

10

Thymidine-DMTr-5'-CEP

ANP-467410(2)-3'-CPG (Mild base protection)(DNA Synthesis)(3)-3'-Polystyrene (DNA Synthesis)(4)-3'-Non-clevable long chain spacer (DNA Synthesis)(5)-3'-Oxalyl CPG (Mild base protection) (DNA Synthesis)(6)-Amino CPG (DNA Synthesis)
Amino Icaa CPG Support 500Å(7)-UnyLinker CPG (DNA Synthesis)

DNA:5'→ 3' Synthesis
A: CE Phosphoramidites (5'→ 3' DNA Synthesis)(1)-5'-CE Phosphoramidite

195

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

Deoxyadenosine (N-Bz)-DMTr-5'-Icaa CPG

N-3351-05/10/20

10Deoxycytidine (N-Bz)-DMTr-5'-Icaa CPG

N-3352-05/10/20

10Deoxyguanosine (N-iBu)-DMTr-5'-Icaa CPG

N-3353-05/10/20

10Thymidine-DMTr-5'-Icaa CPG

N-3354-05/10

10

Deoxyadenosine (N-Bz)-DMTr-5'-succinyl Polymeric Support

N-7518-03

11

Deoxycytidine (N-Bz)-DMTr-5'-succinyl Polymeric Support

N-7519-03

11

P-O-Benzyl-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-6731

9P-O-Benzyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-6732

9

P-O-Benzyl-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-6733

9P-O-Benzyl-thymidine- DMTr-3'-CEP

ANP-6734

9

P-O-Ethyl-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-6541

103

P-O-Ethoxy-deoxycytidine (N-PAC)-DMTr-3'-CEP

ANP-5542

103

P-O-Ethyl-deoxyadenosine (N-PAC)-DMTr-3'-CEP

ANP-5541

103

P-O-Ethyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-6542

103

P-O-Ethyl-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-6543

103

P-O-Ethyl-deoxyguanosine (N-PAC)-DMTr-3'-CEP

ANP-5543

103

P-O-Ethyl-thymidine-DMTr-3'-CEP

ANP-6544

103

Deoxyadenosine (N-Bz)-DMTr-3'-(H)-phosphonate TEA salt

ANP-3410

14

Deoxycytidine (N-Ac)-DMTr-3'-(H)-phosphonate TEA salt

ANP-3414

14

Deoxycytidine (N-Bz)-DMTr-3'-(H)-phosphonate TEA salt

ANP-3411

14

Deoxyguanosine (N-iBu)-DMTr-3'-(H)-phosphonate TEA salt

ANP-3412

14

Thymidine-DMTr-3'-(H)-phosphonate TEA salt

ANP-3413

14

P-O-Isopropyl-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-6901

107

P-O-Isopropyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-6902

107

P-O-Isopropyl-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-6903

107

P-O-Isopropyl-thymidine-DMTr-3'-CEP

ANP-6904

107

P-Methyl-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-7551

105

P-Methyl-deoxycytidine (N-iBu)-DMTr-3'-CEP

ANP-7556

105

P-Methyl-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-7553

105

P-Methyl-deoxyinosine-DMTr-3'-CEP

ANP-7558

105

P-Methyl-deoxyuridine-DMT-3'-CEP

ANP-7557

105

P-Methyl-thymidine-DMTr-3'-CEP

ANP-7554

105

P-Methyl-deoxyadenosine (N-PAC)-DMTr-3'-CEP

ANP-5531

107

P-Methyl-deoxyadenosine(N-PAC)-MMTr-3'-CEP

ANP-5536

107

P-Methyl-deoxycytidine (N-PAC)-DMTr-3'-CEP

ANP-5532

107

B: Supports (5'→ 3' DNA Synthesis)(1)-5'-CPG(2)-5’-succinyl polymeric support

DNA:Backbone modification
A: Benzyl Phosphoramidites (DNA Synthesis)

B: Ethyl Phosphoramidites (DNA Synthesis)

C: H-Phosphonate monomers (DNA Synthesis)

D: Isopropyl Phosphoramidites (DNA Synthesis)

E: Methyl Phosphonamidites (DNA Synthesis)

F: Methyl Phosphonamidites (mild base protection) (DNA Synthesis)

196

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

P-Methyl-deoxyguanosine (N-tBPAC)-MMTr-3'-CEP

ANP-5537

107

P-Methyl-deoxyguanosine (N-tBPAC)-DMTr-3'-CEP

ANP-5533

107

P-O-Methyl-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-3761

8

P-O-Methyl-deoxyadenosine (N-Bz)-MMTr-3'-CEP

ANP-3766

8

P-O-Methyl-deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-3769

8

P-O-Methyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-3762

8

P-O-Methyl-deoxyguanosine (N-DMA)-DMTr-3'-CEP

ANP-3768

8

P-O-Methyl-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-3763

8

P-O-Methyl-deoxyguanosine (N-iBu)-MMTr-3'-CEP

ANP-3767

8

P-O-Methyl-thymidine-DMTr-3'-CEP

ANP-3764

85-Methyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-6421

28

5-Methyl-deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

N-1353-05/10/20

28

5-Methyl-deoxycytidine (N-DMF)-DMTr-3'-CEP

ANP-6422

28

5-Methyl-deoxycytidine (N-DMF)-DMTr-3'-Icaa CPG

N-1355-05/10/20

28

2',3'-Dideoxyadenosine (N-Bz)-DMTr-5'-CEP

DDN-7051

48

2',3'-Dideoxyadenosine (N-Bz)-DMTr-N-succinyl-Icaa CPG

N-7368-05

48

2',3'-Dideoxycytidine (N-Bz)-DMTr-5'-CEP

DDN-7052

48

2',3'-Dideoxycytidine (N-Bz)-DMTr-N-succinyl-Icaa CPG

N-7369-05

48

2',3'-Dideoxyguanosine (N-iBu)-DMTr-5'-CEP

DDN-7053

48

2',3'-Dideoxythymidine-DMTr-5'-CEP

DDN-7054

48

2'-O-Trifluoroacetamidopropyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-7116

31

2'-O-Trifluoroacetamidopropyl-deoxyuridine-DMTr-3'-CEP

ANP-7115

31

3'-Amino(MMTr)-thymidine-5'-CEP

ANP-8454

31

3'-Amino(TFA)- deoxycytidine (N-Bz)-5'-CEP

ANP-1242

31

3'-Amino(TFA)-deoxyuridine-5'-CEP

ANP-1245

31

5'-Amino(MMTr)-Thymidine-3'-CEP

ANP-9402

31

5'-Amino-thymidine 3'-Icaa CPG

N-9506-05/10

31

5'-O-Methyl-deoxyadenosine (N-Bz)-3'-CEP

ANP-5511

49

5'-O-Methyl-deoxycytidine (N-Bz)-3'-CEP

ANP-551249

5'-O-Methyl-deoxyguanosine (N-iBu)-3'-CEP

ANP-5513

49

5'-O-Methyl-thymidine-DMTr-3'-CEP

ANP-5514

49

Deoxyinosine-DMTr-3'-CEP

ANP-6411

28

Deoxyinosine-DMTr-3'-Icaa CPG

N-5108-05/10/20

28

Deoxynebularine (Deoxypurine-DMTr-3'-CEP )ANP-7601

42

Deoxynebularine-3'-Icaa CPG; Deoxypurine-DMTr-3'-Icaa CPG

N-9503-05/10

42

Deoxyuridine-DMTr-3'-CEP

ANP-6131

28

Deoxyuridine-DMTr-3'-Icaa CPG

N-5107-05/10/20

28

Iso-deoxycytidine (N-DBF)-DMTr-3'-CEP

ANP-4269

43

G: Methyl Phosphoramidites (DNA Synthesis)

DNA:Duplex Stabilization
A: DNA Bases affecting Duplex Stability

DNA:PCR/Sequence Utility
A: DNA Chain Terminator

5'-O-Methyl Oligonucleotides

B: DNA Duplex Effect197

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

Iso-deoxycytidine (N-DBF)-DMTr-3'-Icaa CPG

N-9929-05/10

43

Iso-deoxyguanosine (N-DBF)-DMTr-3'-CEP

ANP-4268

43

Iso-deoxyguanosine (N-DBF)-DMTr-3'-Icaa CPG

N-9927-05/10

43

6-Chloro-deoxypurine-DMTr-3'-CEP

ANP-7706

42

2,6-Diamino-deoxypurine (N2, N6-PAC)-DMT-3'-CEP; 2-Amino-deoxyadenosine (N2, N6-PAC)--DMTr-3’-CEP

ANP-9316-DI

42

DNA:Structural Studies
A: DNA Structrure/activity Relationship2,6-Diamino-deoxypurine (N , N -PAC)-DMT-3'-Icaa CPG; 2-Amino-deoxyadenosine (N , N -PAC)--DMTr-3’-Icaa CPG

N-9512-05-DI/10-DI

42

2-Amino-deoxyadenosine(N2, N6-PAC)--DMTr-3’-CEP

ANP-9316-DI

42
42

2

6

2

6

2-Amino-deoxypurine (N-DMF)-DMTr-3'-CEP

ANP-9315-2

2-Amino-deoxypurine (N-DMF)-DMTr-3'-Icaa CPG

N-9511-05/10

42

2-Amino-2’-deoxypurine-riboside 3’-lcaa CPG

N-9519-05/10

42

2-Thio-deoxyuridine-DMTr-3'-CEP

ANP-9214

27

2-Thio-deoxyuridine-DMTr-3'-Icaa CPG

N-9510-05/10

27

2-Thio-thymidine-DMTr-3'-CEP

ANP-9213

27

2-Thio-thymidine-DMTr-3'-Icaa CPG

N-9509-05/10

27

4-Thio-thymidine-DMTr-3'-CEP

ANP-6414

27

4-Thio-thymidine-DMTr-3'-Icaa CPG

N-9925-05/10

27

4-Thio-deoxyuridine-DMTr-3'-CEP

ANP-7624

27

4-Thio-deoxyuridine-DMTr-3'-Icaa CPG

N-9758-05/10

27
35

6-Thio-deoxyguanosine-DMTr-3'-CEP

ANP-7628

7-Deaza-7-iodo-deoxyadenosine (N-DMF)-DMTr-3'-CEP

ANP-4586

34

7-Deaza-7-iodo-deoxyguanosine (N-DMF)-DMTr-3'-CEP

ANP-458934
34

7-Deaza-7-propargyl-(Amino-TFA)-deoxyadenosine (N-DMF)-DMTr-3'-CEP

ANP-1339

7-Deaza-7-propargyl-(Amino-TFA)-deoxyguanosine (N-DMF)-DMTr-3'-CEP

ANP-1354

34

7-Deaza-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-481533

7-Deaza-deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-8777-05/10

33

7-Deaza-deoxyguanosine (N-Ac)-DMTr-3'-CEP

ANP-485833

7-Deaza-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-485733

7-Deaza-deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-8778-05/10

33

7-Deaza-deoxyguanosine (N-iBu)-DMTr-5'-CEP

ANP-4679

34

7-Deaza-deoxyinosine-DMTr-3'-CEP

ANP-1146

33

7-Deaza-deoxyinosine-DMTr-3'-Icaa CPG

N-8779-05/10

33

B: DNA Structrure/activity Relationship
3',5'-Bis-CEP-deoxyadenosine (N-Bz)

ANP-7761

49

3',5'-Bis-CEP-deoxycytidine (N-Ac)

ANP-7762

49

3',5'-Bis-CEP-deoxyguanosine (N-iBu)

ANP-7763

49

3',5'-Bis-CEP-thymidine

ANP-7764

49

3'-Bis-(diisopropylamino)-thymidine-phosphoramidite-5'-DMT

ANP-7766

49

Deoxyadenosine (N-Bz) DMTr 2'-CEP

ANP-9312

35

Deoxyadenosine (N-Bz)-DMTr-2'-Icaa CPG; Cardycepin

N-9502-05/10

35

4-Triazolyl-deoxyuridine-DMTr-3'-CEP

ANP-9211

43

4-Triazolyl-thymidine-DMTr-3'-CEP

ANP-9212

43

C: DNA 2'-5' Linked Oligonucleotides

D: DNA Convertible Nucleosides

198

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#Page#

8-Oxo-deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-5300-05/10

47

8-Oxo-deoxyadenosine(N-Bz)-DMTr-3'-CEP

ANP-930147

8-Oxo-deoxyguanosine (N-Ac)-DMTr-3'-Icaa CPG

N-9400-05/10

47

8-Oxo-deoxyguanosine (N-DMF)-3'-CEP

ANP-9311-2

47

8-Oxo-deoxyguanosine (N-DMF)-DMTr-3'-Icaa CPG

N-9501-05/10

47

Abasic CPG; 1,2-dideoxy-β-D-ribose-DMTr-3-Icaa CPG

N-1423-05/10

47

Abasic Phosphoramidites; 1,2-dideoxy-β-D-ribose- DMTr-3-CEP

ANP-7058

47

Abasic reverse CPG; 1,2-dideoxy-β-D-ribose-DMTr-5-Icaa CPG

N-1424-05/10

47

Abasic reverse Phosphoramidites; 1,2-dideoxy-β-D-ribose-DMTr-5-CEP

ANP-1422

47

2-Fluoro-O6-trimethylsilyl-ethoxy-deoxyinosine-DMTr-3'-CEP

ANP-7702

40

2-Fluoro-O6-trimethylsilyl-ethoxy-deoxyinosine-DMTr-3'-Icaa CPG)

N-9926-05/10

40

5-Bromo-deoxycytidine (N-Bz)-DMTr 3'-CEP

ANP-6141

36

5-Bromo-deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

N-7362-05/10

37

5-Bromo-deoxyuridine-DMTr-3'-CEP

ANP-6415

36

5-Bromo-deoxyuridine-DMTr-3'-Icaa CPG

N-1378-05/10

37

5-Fluoro-deoxyuridine-DMTr-3'-CEP

ANP-6151

36

5-Fluoro-deoxyuridine-DMTr-3'-Icaa CPG

N-7365-05/10

37

5-Iodo-deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

N-4612-05/10

37

5-Iodo-deoxycytidine (N-DBF)-DMTr-3'-CEP

ANP-4591

36

5-Iodo-deoxycytidine (N-DBF)-DMTr-3'-Icaa CPG

N-7363-05/10

37

5-Iodo-deoxyuridine-DMTr-3'-CEP

ANP-4611

36

5-Iodo-deoxyuridine-DMTr-3'-Icaa CPG

N-7364-05/10

37

5-Iodo-thymidine-DMTr-3'-CEP

ANP-4613

36

8-Bromo-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-4703

37

8-Bromo-deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-4705-05/10

37

8-Bromo-deoxyadenosine (N-DBF)-DMTr-3'-CEP

ANP-4702

37

8-Bromo-deoxyadenosine (N-DBF)-DMTr-3'-Icaa CPG

N-4704-05/10

37

8-Bromo-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-6152

37

8-Bromo-deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-9921-05/10

37

8-Methyl-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-9274

41

8-Methyl-deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-9924-05/10

41

N -Methyl-deoxyadenosine (N-Fmoc)-DMTr-3'-Icaa CPG

N-9980-05/10

39

N1-Methyl-deoxyguanosine (N-DMF)-DMTr-3'-CEP

E: DNA Damage/Repair

F: DNA Halogenated Nucleosides

G: DNA Mutagenesis

1

ANP-6122

38

1

ANP-6121

38

1

N-9981-05/10

39

2

ANP-6445

403

ANP-3857

38

3

ANP-3851

38

3

ANP-6153

38

3

N -Ethyl-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-3856

39

N3-Methyl-thymidine-DMTr-3'-Icaa CPG

N-9922-05/10

39

N -Methyl-deoxyadenosine (N-FmoC)-DMTr-3'-CEP
N -Methyl-deoxyguanosine (N-DMF)-DMTr-3'-Icaa CPG
N -t-Butyldithiopropyl-O6-TMS-ethyl-deoxyinosine-DMTr-3'-CEPN -Cyanoethyl-thymidine-DMTr-3'-CEP
N -Methyl-deoxycytidine (N-Bz)-DMTr-3'-CEP
N -Methyl-thymidine-DMTr-3'-CEP

N -Ethyl-deoxycytidine-DMTr-3'-CEP

ANP-6444

39

N4-Ethyl-deoxycytidine-DMTr-3'-Icaa CPG

N-9923-05/10

39

4

199

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

N6-Methyl-deoxyadenosine-DMTr-3'-CEP

ANP-385539

6

2

ANP-927640

6

2

ANP-9277

40

O -Diphenylcarbanoyl-deoxyguanosine (N -iBu)-DMTr-3'-CEP
O -diphenylcarbanoyl-deoxyguanosine (N -iBu)-DMTr-3'-P-O-Methyl-CEP
DNA Dimer Phosphoramidites
AA-P-CEP-3'-CEP Dimer

ANP-2501-CE

13

AC-P-CEP-3'-CEP Dimer

ANP-2502-CE

13
13

AG-P-CEP-3'-CEP Dimer

ANP-2503-CE

AT-P-CEP-3'-CEP Dimer

ANP-2504-CE

13

CA-P-CEP-3'-CEP Dimer

ANP-2505-CE

13

CC-P-CEP-3'-CEP Dimer

ANP-2506-CE

13
13

CG-P-CEP-3'-CEP Dimer

ANP-2507-CE

CT-P-CEP-3'-CEP Dimer

ANP-2508-CE

13

GA-P-CEP-3'-CEP Dimer

ANP-2509-CE

13

GC-P-CEP-3'-CEP Dimer

ANP-2510-CE

13

GG-P-CEP-3'-CEP Dimer

ANP-2511-CE

13

GT-P-CEP-3'-CEP Dimer

ANP-2512-CE

13

TA-P-CEP-3'-CEP Dimer

ANP-2513-CE

13
13

TC-P-CEP-3'-CEP Dimer

ANP-2514-CE

TG-P-CEP-3'-CEP Dimer

ANP-2515-CE

13

TT-P-CEP-3'-CEP Dimer

ANP-2516-CE

13

β-L-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-8031

44

β-L-deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-3521-05/10

45

β-L-deoxycytidine (N-BZ)-DMTr-2'-Icaa CPG

N-4062-05/10

45

β-L-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-8032

44

β-L-deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

N-3522-05/10

45

β-L-deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-8035

44

β-L-deoxycytidine (N-Ac)-DMTr-3'-Icaa CPG

N-3525-05/10

45

β-L-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-8033

44

β-L-deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-3523-05/10

45

β-L-deoxyuridine-DMTr-3'-CEP

ANP-8036

44

β-L-Thymidine-DMTr-3'-CEP

ANP-8034

44

β-L-Thymidine-DMTr-3'-Icaa CPG

N-3524-05/10

45

Ara-(2'-O-Ac)-Adenosine (N-Bz)-DMTr-3'-CEP; Adenosine arabinose

ANP-1711

32
32

H: DNA Spiegelmers

I: Ara-amidites-DNA Therapeutic Applications
Ara-(2'-O-Ac)-Adenosine (N-Bz)-DMTr-3'-Icaa CPG

N-7366-05/10/20

Ara-(2'-O-Ac)-Cytidine (N-Bz)-DMTr-3'-CEP; Cytidine arabinose

ANP-1712

32

Ara-(2'-O-Ac)-Cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-7367-05/10/20

32

Ara-(2'-O-Ac)-Cytidine (N-Ac)-DMTr-3'-CEP; Cytidine arabinose

ANP-1714

32
32

Ara-(2'-O-Ac)-Guanosine (N-iBu)-DMTr-3'-CEP; Guanosine arabinose

ANP-1713

Ara-(2'-O-Ac)-Guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-7421-05/10/20

32

Ara-(2'-O-Ac)-Uridine-DMTr-3'-CEP; Uridine arabinose

ANP-1715

32

Ara-(2'-O-Ac)-Uridine-DMTr-3'-Icaa CPG

N-7422-05/10/20

32

Ara-(2'-O-Me)-adenosine (N-Bz)-DMTr-3'-CEP

ANP-1716

111

Ara-(2'-O-Me)-adenosine (N-Bz)-DMTr-3'-Icaa CPG

N-7423-05/10

111

Ara-(2'-O-Me)-cytidine (N-Ac)-DMTr-3'-CEP

ANP-1718

111

200

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INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#Page#

Ara-(2'-O-Me)-cytidine (N-Ac)-DMTr-3'-Icaa CPG

N-7425-05/10

111

Ara-(2'-O-Me)-cytidine (N-Bz)-DMTr-3'-CEP

ANP-1717

111

Ara-(2'-O-Me)-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-7424-05/10

111

Ara-(2'-O-Me)-guanosine (N-iBu)-DMTr-3'-CEP

ANP-1719

111

Ara-(2'-O-Me)-guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-7426-05/10

111

Ara-(2'-O-Me)-uridine-DMTr-3'-CEP

ANP-1721

111

Ara-(2'-O-Me)-uridine-DMTr-3'-Icaa CPG

N-7427-05/10

111

Alpha-D-5-methyl-deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

ANP-1756

29

Alpha-D-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-1651

29

Alpha-D-deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-1751-05/10/20

30

Alpha-D-deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-4676

29

Alpha-D-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-1652

29

Alpha-D-deoxycytidine (N-Bz)-DMTr-3'-Icaa CPG

N-1752-05/10/20

30

Alpha-D-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-1653

29

Alpha-D-deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-1753-05/10/20

30

Alpha-D-thymidine-DMTr-3'-CEP

ANP-1654

29

Alpha-D-thymidine-DMTr-3'-Icaa CPG

N-1754-05/10/20

30

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), PolyPlex Oligonucleotide Synthesizer

RN-1447-S/M/L-PX

25

Acetonitrile Wash Grade,PolyPlex Oligonucleotide Synthesizer

RN-1448-M/L-PX

25

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1467-M-PX

25

Activation Reagent (0.25M 5-Ethylthio Tetrazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1466-M-PX

25

Activation Reagent (0.45M 5-Ethylthio Tetrazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1551-M/L-PX

25

Activation Reagent (BMT Solution) (0.3M Benzylthio Tetrazole/Acetonitrile) PolyPlex Oligonucleotide Synthesizer

RN-1452

25

AMA Reagent, PolyPlex Oligonucleotide Synthesizer

RN-1450-PX

25

CAP A (Acetic Anhydride/Pyridine/THF),PolyPlex Oligonucleotide Synthesizer

RN-1458-M-PX

25

CAP B (10% N-Methylimidazole/THF),PolyPlex Oligonucleotide Synthesizer

RN-1481-M-PX

25

CAP B (16% N-Methylimidazole/THF), PolyPlex Oligonucleotide Synthesizer

RN-7776-M-PX

25

DDTT Solution 1 [0.05M] (Sulfurizing Reagent), PolyPlex Oligonucleotide Synthesizer

RN-168825

DDTT Solution 1 [0.10M] (Sulfurizing Reagent), PolyPlex Oligonucleotide Synthesizer

RN-168925

DMTr Removal Reagent (3% Dichloracetic Acid/Dichloromethane), PolyPlex Oligonucleotide Synthesizer

RN-1468-M-PX

25

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), PolyPlex Oligonucleotide Synthesizer

RN-1462-L-PX

25

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), PolyPlex Oligonucleotide Synthesizer

RN-1455-L-PX

25

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), PolyPlex Oligonucleotide Synthesizer

RN-1456-M-PX

25

Silanized Bottles for Beaucage Reagent, PolyPlex Oligonucleotide Synthesizer

BL-1536-S/M/L-PX

25

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), PolyPlex
Oligonucleotide Synthesizer

RN-1535-S/M/L-PX

25

Thiophenol/Triethylamine/Dioxane, PolyPlex Oligonucleotide Synthesizer

RN-1465-PX

25

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), MerMade Oligonucleotide Synthesizer

RN-1447-S/M/L-MR

24

Acetonitrile Wash Grade, MerMade Oligonucleotide Synthesizer

RN-1448-M/L-MR

24

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1467-M/L-MR

24

Activation Reagent (0.25M 5-Ethylthio Tetrazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1466-M/L-MR

24

Activation Reagent (0.45M 5-Ethylthio Tetrazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1551-M/L-MR

24

J: Alpha-deoxy amidites-DNA Diagnostic Applications

Solvents/Reagents-DNA Synthesis
A:PolyPlex Oligo-Synthesizer

B: MerMade Oligo-Synthesizer

201

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

Activation Reagent (BMT Solution) (0.3M Benzylthio Tetrazole/Acetonitrile) MerMade Oligonucleotide Synthesizer

RN-1452

24

AMA Reagent, MerMade Oligonucleotide Synthesizer

RN-1450-MR

24

CAP A (Acetic Anhydride/Pyridine/THF),MerMade Oligonucleotide Synthesizer

RN-1458-M/L-MR

24

CAP B (10% N-Methylimidazole/THF), MerMade Oligonucleotide Synthesizer

RN-1481-SS/S-MR

24

CAP B (16% N-Methylimidazole/THF), MerMade Oligonucleotide Synthesizer

RN-7776-SS/S-MR

24

DDTT Solution 1 [0.05M] (Sulfurizing Reagent), MerMade Oligonucleotide Synthesizer

RN-168824

DDTT Solution 1 [0.10M] (Sulfurizing Reagent), MerMade Oligonucleotide Synthesizer

RN-168924

DMTr Removal Reagent (2.5% Dichloracetic Acid/Dichloromethane), MerMade Oligonucleotide Synthesizer

RN-1468-M/L-MR

24

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), MerMade Oligonucleotide Synthesizer

RN-1462-M/L-MR

24

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), MerMade Oligonucleotide Synthesizer

RN-1455-S/M-MR

24

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), MerMade Oligonucleotide Synthesizer

RN-1456-S/M-MR

24

Silanized Bottles for Beaucage Reagent, MerMade Oligonucleotide Synthesizer

BL-1536-S/M/L-MR

24

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), MerMade
Oligonucleotide Synthesizer

RN-1535-S/M/L-MR

24

Thiophenol/Triethylamine/Dioxane, MerMade Oligonucleotide Synthesizer

RN-1465-MR

24

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), Expedite Oligonucleotide Synthesizer

RN-1447-S/M/L-EX

23

Acetonitrile Wash Grade, Expedite Oligonucleotide Synthesizer

RN-1448-M/L-EX

23

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1467-SS/S/M/L-EX

23

Activation Reagent (0.25M 5-Ethylthio Tetrazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1466-SS/S/M/L-EX

23

Activation Reagent (0.45M 5-Ethylthio Tetrazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1551-SS/S/M/L-EX

23

Activation Reagent (BMT Solution) (0.3M Benzylthio Tetrazole/Acetonitrile) Expedite Oligonucleotide Synthesizer

RN-1452

23

AMA Reagent, Expedite Oligonucleotide Synthesizer

RN-1450-EX

23

CAP A (Acetic Anhydride/Pyridine/THF), Expedite Oligonucleotide Synthesizer

RN-1458-SS/S/M/L-EX

23

CAP B (10% N-Methylimidazole/THF), Expedite Oligonucleotide Synthesizer

RN-1481-SS/S/M/L-EX

23

CAP B (16% N-Methylimidazole/THF), Expedite Oligonucleotide Synthesizer

RN-7776-SS/S/M/L-EX

23

DMTr Removal Reagent (2.5% Dichloracetic Acid/Dichloromethane), Expedite Oligonucleotide Synthesizer

RN-1468-M/L-EX

23

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), Expedite Oligonucleotide Synthesizer

RN-1462-M/L-EX

23

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), Expedite Oligonucleotide Synthesizer

RN-1455-S/M/L-EX

23

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), Expedite Oligonucleotide Synthesizer

RN-1456-S/M/L-EX

23

Silanized Bottles for Beaucage Reagent, Expedite Oligonucleotide Synthesizer

BL-1536-S/M/L-EX

23

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), Expedite
Oligonucleotide Synthesizer

RN-1535-S/M/L-EX

23

Thiophenol/Triethylamine/Dioxane, Expedite Oligonucleotide Synthesizer

RN-1465-EX

23

Activator (Benzyl thio tetrazole; 0.2M in acetonitrile) Akta Oligonucleotide Synthesizer

RN-2232-M-OP

22

Cap A (N-Methyl imidazole; 20% in Acetonitrile) Akta Oligonucleotide Synthesizer

RN-2202-M-OP

22

Cap B1 (Acetic Anhydride; 40% (v:v) in Acetonitrile) Akta Oligonucleotide Synthesizer

RN-2217-M-OP

22

Cap B2 (Symmetrical Collidine; 60% (v:v) in Acetonitrile, Akta Oligonucleotide Synthesizer

RN-2225-M-OP

22

Deblock (3% DCA in Toluene) Akta Oligonucleotide Synthesizer

RN-2242-M-OP

22

Oxidizer 4 Liter 50 mM Iodine in 10% Water/Pyridine) Akta Oligonucleotide Synthesizer

RN-2238-M-OP

22

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), ABI 3900 Oligonucleotide Synthesizer

RN-1447-L-AB39

21

Acetonitrile Wash Grade, ABI 3900 Oligonucleotide Synthesizer

RN-1448-M/L-AB39

21

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), ABI 3900 Oligonucleotide Synthesizer

RN-1467-M/L-AB39

21

Activation Reagent (0.25M 5-Ethylthio Tetrazole/Acetonitrile)

RN-1466-M/L-AB39

21

Activation Reagent (0.45M 5-Ethylthio Tetrazole/Acetonitrile), ABI 3900 Oligonucleotide Synthesizer

RN-1551-M/L-AB39

21

C:Expedite Oligo-Synthesizer

D:Expedite Oligo-Synthesizer

E:ABI 3900 Oligo-Synthesizer

202

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Email: info@chemgenes.com

INDEX-1: Common NameDNA Synthesis
Product Name

Catalog#

Page#

Activation Reagent (BMT Solution) (0.3M Benzylthio Tetrazole/Acetonitrile)

RN-1452

21

AMA Reagent, ABI 3900 Oligonucleotide Synthesizer

RN-1450-AB39

21

CAP A (Acetic Anhydride/Pyridine/THF), ABI 3900 Oligonucleotide Synthesizer

RN-1458-M/L-AB39

21

CAP B (10% N-Methylimidazole/THF), ABI 3900 Oligonucleotide Synthesizer

RN-1481-M/L-AB39

21

CAP B (16% N-Methylimidazole/THF), ABI 3900 Oligonucleotide Synthesizer

RN-7776-M/L-AB39

21

DDTT Solution 1 [0.05M] (Sulfurizing Reagent), ABI 3900 Oligonucleotide Synthesizer

RN-1688

21

DDTT Solution 1 [0.10M] (Sulfurizing Reagent), ABI 3900 Oligonucleotide Synthesizer

RN-1689

21

DMT Removal Reagent (3% Dichloracetic Acid/Dichloromethane), ABI 3900 Oligonucleotide Synthesizer

RN-1468-M/L-AB39

21

DMT Removal Reagent (3% Trichloracetic Acid/Dichloromethane)

RN-1462-M/L-AB39

21

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), ABI 3900 Oligonucleotide Synthesizer

RN-1455-M/L-AB39

21

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), ABI 3900 Oligonucleotide Synthesizer

RN-1456-M/L-AB39

21

Silanized Bottles for Beaucage Reagent, ABI 3900 Oligonucleotide Synthesizer

BL-1536-S/M/L-AB39

21

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), ABI 3900
Oligonucleotide Synthesizer

RN-1535-L-AB39

21

Thiophenol/Triethylamine/Dioxane, ABI 3900 Oligonucleotide Synthesizer

RN-1465-AB39

21

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), ABI Oligonucleotide Synthesizer

RN-1447-S/M/L-AB30

20

Acetonitrile Wash Grade, ABI Oligonucleotide Synthesizer

RN-1448-M/L-AB30

20

Activation Reagent ((0.25M 5-Ethylthio Tetrazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1466-SS/S/M/L-AB30

20

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1467-SS/S/M/L-AB30

20

Activation Reagent (0.45M 5-Ethylthio Tetrazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1551-SS/S/M/L-AB30

20

Activation Reagent (BMT Solution) (0.3M Benzylthio Tetrazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1452

20

AMA Reagent, ABI Oligonucleotide Synthesizer

RN-1450-AB30

20

CAP A (Acetic Anhydride/Pyridine/THF), ABI Oligonucleotide Synthesizer

RN-1458-SS/S/M/L-AB30

20

CAP B (10% N-Methylimidazole/THF), ABI Oligonucleotide Synthesizer

RN-1481-SS/S/M/L-AB30

20

CAP B (16% N-Methylimidazole/THF), ABI Oligonucleotide Synthesizer

RN-7776-SS/S/M/L-AB30

20

DMT Removal Reagent (3% Dichloracetic Acid/Dichloromethane), ABI Oligonucleotide Synthesizer

RN-1468-M/L-AB30

20

DMT Removal Reagent (3% Trichloracetic Acid/Dichloromethane), ABI Oligonucleotide Synthesizer

RN-1462-M/L-AB30

20

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), ABI Oligonucleotide Synthesizer

RN-1455-S/M/L-AB30

20

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), ABI Oligonucleotide Synthesizer

RN-1456-S/M/L-AB30

20

Silanized Bottles for Beaucage Reagent, ABI Oligonucleotide Synthesizer

BL-1536-S/M/L-AB30

20

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), ABI Oligonucleotide
Synthesizer

RN-1535-L-AB30

20

Thiophenol/Triethylamine/Dioxane, ABI Oligonucleotide Synthesizer

RN-1465-AB30

20

Acetonitrile/Pyridine (50:50), Anhydrous (Diluent for Monomers)

RN-4523-P

19

Acetonitrile/Pyridine (95:5), Anhydrous (Diluent for Activator)

RN-1356-P2

19

Acetonitrile/Pyridine (wash solvent)

RN-7684-AP

19

Activator for monomers and Capping Reagent (Adamantane catbonyl chloride)

RN-6664

19

Capping for ABI Synthesizers (Isopropyl Phosphite/Acetonitrile/Pyridine)

RN-6645-IP

19

Dipentaflurophenyl Carbonate (Reagent for H-phosphonate)

RN-646419

Oxidation Solution 1 (Iodine in Pyridine/H2O/THF)

RN-1210-PHT

19

Oxidation Solution 2 (THF/H2O/TEA)

RN-1220-THF

19

Ammonia Free Oligo Deprotection Solution

RN-1435

59

Deprotection solution for Levulinyl

CLP-717112, 129

F:ABI Oligo-Synthesizer

G: Solvents/Reagents For H-phosphonate Chemistry

H: Deprotection solution for DNA Synthesis

203

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-1: Common NameDNA Synthesis / RNA Synthesis
Product Name

Catalog#

Page#

Empty Column, Aluminium Caps, ABI 392/394

E-1007-AB30

18

Empty Column, Aluminium Caps, ABI 392/394

E-1007-15-AB30

18

Empty Synthesis Column, Aluminium Caps, Expedite Style

E-1007-02-EX

18

Empty Synthesis Column, Aluminium Caps, Expedite Style

E-1007-10-EX

18

Empty Synthesis Column, Aluminium Caps, Expedite Style

E-1007-100-EX

18

Empty Synthesis Column, mermade style,

E-1007-AB39

18

Replacement filters

EPC-1008

18

Barrel-4 ml

CSS-3940-S

54

Barrel-4 ml

CSS-3940-M

54

Barrel-4 ml

CSS-3940-L

54

Barrel-8 ml

CSS-3960-S

54

Barrel-8 ml

CSS-3960-M

54

Barrel-8 ml

CSS-3960-L

54

Cartridge-L

CSS-3920-L

54

Cartridge-M

CSS-3920-M

54

Cartridge-S

CSS-3920-S

54

DNA Purification, 96 Well Collection Plate (Pack of 12)

GS-3280

51

DNA Purification, 96 Well Oligonucleotide Synthesis plate

GS-8361

51

DNA Purification, Puri-Pak PlateTM (Not Shown)

GS-1154

51
51

Empty Columns & Filters-DNA Synthesis
A: Empty Columns & Filters

DNA purification
B: DNA purification Barrels

C: DNA purification Cartridges

D: DNA purification Plates

DNA Purification, 96 Well Collection Plate (1 Plate)GS-3280

DNA Purification, Genesys Manifold for 96-well Format GeneSys-1

GS-8366

51

DNA Purification, Genesys-24 (Not Shown)

GS-1158

51

DNA Purification, Puri-Pak PlateTM

GS-3249

51

DMT-1972

52
52

E: DNA purification Traps
Drying Traps, Extra Large
Drying Traps, Large

DMT-1973

Drying Traps, Medium

DMT-1974

52

Drying Traps, Small

DMT-1975

52

Adenosine (N-Ac)-DMTr-3'-CEP

ANP-4546

57

Adenosine (N-Bz)-DMTr-3'-CEP

ANP-5671

57

Adenosine (N-Bz)-MMTr-3'-CEP

ANP-5676

57

Cytidine (N-Ac)-DMTr-3'-CEP

ANP-6676

57

Cytidine (N-Bz)-DMTr-3'-CEP

ANP-5672

57

Cytidine (N-Bz)-MMTr-3'-CEP

ANP-5685

57

Guanosine (N-Ac)-DMTr-3'-CEP

ANP-4547

57

Guanosine (N-DMF)-DMTr-3'-CEP

ANP-5678

57

Guanosine (N-iBu)-DMTr-3'-CEP

ANP-5673

57

RNA Synthesis
A: CE Phosphoramidites: TBDMS Protected (RNA synthesis)(1)-TBDMS Protected (RNA synthesis)

204

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Email: info@chemgenes.com

INDEX-1: Common NameRNA Synthesis
Product Name

Catalog#

Page#

Guanosine (N-iBu)-MMTr-3'-CEP

ANP-5677

57

Uridine-DMTr-3'-CEP

ANP-5674

57

Uridine-MMTr-3'-CEP

ANP-5688

57

Adenosine (N-PAC)-DMTr-3'-CEP

ANP-6671

59

Adenosine (N-PAC)-MMTr-3'-CEP

ANP-6678

59

Cytidine (N-Ac)-DMTr-3'-CEP

ANP-6676

59

Cytidine (N-PAC)-DMTr-3'-CEP

ANP-6672

59

Cytidine (N-tBPAC)-MMTr-3'-CEP

ANP-6680

59

Guanosine (N-iprPAC)-DMTr-3'-CEP

ANP-6679

59

Guanosine (N-PAC)-DMTr-3'-CEP

ANP-6673

59

Guanosine (N-PAC)-MMTr-3'-CEP

ANP-6677

59

Guanosine (N-Phenyl-Ac)-DMTr-3'-CEP

ANP-5679

59

2'-TOM-Adenosine (N-Ac)-DMTr-3'-CEP

ANP-320169

2'-TOM-Cytidine (N-Ac)-DMTr-3'-CEP

ANP-3202

69

2'-TOM-Guanosine (N-Ac)-DMTr-3'-CEP

ANP-3203

69

2'-TOM-Uridine-DMTr-3'-CEP

ANP-320469

2'-ALE-Adenosine (N-PAc)-5'-NPPOC-3'-CEP

ANP-3211

62

2'-ALE-Cytidine (N-iBu)-5'-NPPOC-3'-CEP

ANP-321262

2'-ALE-Guanosine (N-PAc)-5'-NPPOC-3'-CEP

ANP-3213

62

2'-ALE-Uridine-5'-NPPOC-3'-CEP

ANP-3214

62

2'-Pivom-Adenosine (N-PAc)-DMTr-3'-CEP

ANP-3216

63

2'-Pivom-Cytidine (N-Ac)-DMTr-3'-CEP

ANP-3217

63

2'-Pivom-Guanosine (N-iPrPAC)-DMTr-3'-CEP

ANP-3218

63

2'-Pivom-Uridine-DMTr-3'-CEP

ANP-3219

63

Adenosine (N-Bz)-DMTr-3'-Icaa CPG

N-6101-05/10/20

58

Cytidine (N-Ac)-DMTr-3'-Icaa CPG

N-6106-05/10/20

58

Cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-6102-05/10/20

58

Guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-6103-05/10/20

58

Uridine-DMTr-3'-Icaa CPG

N-6104-05/10/20

58

Adenosine (N-PAC)-DMTr-3'-Icaa CPG

N-P6101-05/10

60

Adenosine (N-tBPAC)-DMTr- 3'-Icaa CPG

N-6207-05/10

60

Cytidine (N-PAC)-DMTr-3'-Icaa CPG

N-P6102-05/10

60

Guanosine (N-PAC)-DMTr-3'-Icaa CPG

N-P6103-05/10

60

Guanosine (N-tBPAC)-DMTr-3'-Icaa CPG

N-6208-05/10

60

Uridine-DMTr-3'-Icaa CPG

N-P6104-05/10

60

Adenosine (N-PAC)-DMTr-3'-oxalyl Icaa-CPG

N-5141-05

61

Ammonia Free Oligo Deprotection Solution

RN-1435

61

Cytidine (N-PAC)-DMTr-3'-oxalyl Icaa CPG

N-5142-05

61(2)-TBDMS Protected (Ultramild base protection) (RNA synthesis)(3)-TOM Protected (RNA synthesis)(4)-Acetal levulinyl ester Protected (RNA synthesis)(5)-Pivaloyloxymethyl Protected (RNA synthesis)

B: Supports (RNA synthesis)(1)-TBDMS Protected 3'-CPG (RNA synthesis)(2)-TBDMS protected 3'-CPG (Ultramild base protection) (RNA synthesis)(3)-TBDMS protected 3'-Oxalyl CPG (RNA synthesis)

205

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-1: Common NameRNA Synthesis
Product Name

Catalog#

Page#

Guanosine (N-iBu)-DMTr-3'-oxalyl Icaa CPG

N-5166-05

61

Guanosine (N-PAC)-DMTr-3'-oxalyl Icaa CPG

N-5143-05

61

Uridine-DMTr-3'-oxalyl Icaa CPG

N-5144-05

61

Adenosine (N-Bz)-DMTr-3'-succinyl Polystyrene

N-6211-03

64

Cytidine (N-Ac)-DMTr-3'-succinyl Polystyrene

N-6216-03

64

Cytidine (N-Bz)-DMTr-3'-succinyl Polystyrene

N-6212-03

64

Guanosine (N-iBu)-DMTr-3'-succinyl Polystyrene

N-6213-03

64

Uridine-DMTr-3'-succinyl Polystyrene

N-6214-03

64

2'-TOM-Adenosine (N-Ac)-DMTr-3'-Icaa CPG

N-3201-05/10

69

2'-TOM-Cytidine (N-Ac)-DMTr-3'-Icaa CPG

N-3202-05/10

69

2'-TOM-Guanosine (N-Ac)-DMTr-3'-Icaa CPG

N-3203-05/10

69

2'-TOM-Uridine-DMTr-3'-Icaa CPG

N-3205-05/10

69

P-O-Methyl-adenosine (N-Bz)-DMTr-3'-CEP

ANP-5691

65

P-O-Methyl-adenosine (N-Bz)-MMTr-3'-CEP

ANP-5696

65

P-O-Methyl-adenosine (N-PAC)-DMTr-3'-CEP

ANP-3861

66

P-O-Methyl-adenosine (N-PAC)-MMTr-3'-CEP

ANP-3866

66

P-O-Methyl-cytidine (N-Bz)-DMTr-3'-CEP

ANP-5692

65

P-O-Methyl-cytidine (N-PAC)-DMTr-3'-CEP

ANP-3862

66

P-O-Methyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-5693

65

P-O-Methyl-guanosine (N-iBu)-MMTr-3'-CEP

ANP-5697

65

P-O-Methyl-guanosine (N-PAC)-DMTr-3'-CEP

ANP-3863

66

P-O-Methyl-guanosine (N-PAC)-MMTr-3'-CEP

ANP-3867

66

P-O-Methyl-uridine-DMTr-3'-CEP

ANP-5694

65

Adenosine (N-Bz)-DMTr-5'-CEP

ANP-3401

67

Cytidine (N-Ac)-DMTr-5'-CEP

ANP-3405

67

Cytidine (N-Bz)-DMTr-5'-CEP

ANP-3402

67

Guanosine (N-iBu)-DMTr-5'-CEP

ANP-3403

67

Guanosine (N-iprPAC)-DMTr-5'-CEP

ANP-3406

67

Uridine-DMTr-5'-CEP

ANP-3404

67

Adenosine (N-Bz)-DMTr-5'-Icaa CPG

N-6201-05/10

67

Cytidine (N-Ac)-DMTr-5'-Icaa CPG

N-6206-05/10

67

Cytidine (N-Bz)-DMTr-5'-Icaa CPG

N-6202-05/10

67

Guanosine (N-iBu)-DMTr-5'-Icaa CPG

N-6203-05/10

67

Uridine-DMTr-5'-Icaa CPG

N-6204-05/10

67(4)-TBDMS protected 3'-Polymeric Support (RNA Synthesis)(6)-TOM protected 3'-CPG (RNA Synthesis)

B: Backbone modification:Methyl Phosphoramidite (RNA Synthesis)

RNA:5'→ 3' Synthesis
A: CE Phosphoramidites: TBDMS Protected (RNA Synthesis)

B: Supports-TBDMS protected 5'-CPG (RNA Synthesis)

206

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INDEX-1: Common Name
O-Alkyl & Antisenses Oligonucleotide Modifications
Product Name

Catalog#Page#

2'-O-Methyl-adenosine (N-Bz)-DMTr-3'-CEP

ANP-5751

93

2'-O-Methyl-adenosine (N-Bz)-MMTr-3'-CEP

ANP-5756

93

2'-O-Methyl-cytidine (N-Ac)-DMTr-3'-CEP

ANP-6756

93

2'-O-Methyl-cytidine (N-Bz)-DMTr-3'-CEP

ANP-5752

93

2'-O-Methyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-5753

93

2'-O-Methyl-guanosine (N-iBu)-MMTr-3'-CEP

ANP-5757

93

2'-O-Methyl-uridine-DMTr-3'-CEP

ANP-5754

93

2'-O-Methyl-adenosine (N-PAC)-DMTr-3'-CEP

ANP-6751

95

2'-O-Methyl-cytidine (N-Ac)-DMTr-3'-CEP

ANP-6756

95

2'-O-Methyl-cytidine (N-PAC)-DMTr-3'-CEP

ANP-6752

95

2'-O-Methyl-guanosine (N-DMF)-DMTr-3'-CEP

ANP-6759

95

2'-O-Methyl-guanosine (N-iPrPAC)-DMTr-3'-CEP

ANP-5761

95

2'-O-Methyl-guanosine (N-PAC)-DMTr-3'-CEP

ANP-6753

95

2'-O-Methyl-uridine-DMTr-3'-CEP

ANP-5754

95

2'-O-Methyl-5-propynyl-uridine-DMTr-3'-CEP

ANP-1347

97

2'-O-Methyl-uridine (C-6)-DMTr-3'-CEP (Amino Modifier)"

ANP-2581

97

2'-O-Methyl-2,6-diamino-purine (N2,N6-diPAC)-DMTr-3'-CEP

ANP-8519

96

2'-O-Methyl-4-triazolyl-uridine-DMTr-3'-CEP

ANP-5604

97

2'-O-Methyl-5-bromo-uridine-DMTr-3'-CEP

ANP-5760

98

2'-O-Methyl-5-iodo-uridine-DMTr-3'-CEP

ANP-5759

98

2'-O-Methyl-5-methyl-cytidine (N-Ac)-DMTr-3'-CEP

ANP-6555

96

2'-O-Methyl-5-methyl-cytidine (N-Bz)-DMTr-3'-CEP

ANP-6556

96

2'-O-Methyl-5-methyl-cytidine (N-DMF)-DMTr-3'-CEP

ANP-6554

96

2'-O-Methyl-5-methyl-uridine (Ribo Thymidine)-DMTr-3'-CEP

ANP-5600

96

2'-O-Methyl-5-propynyl-cytidine (N-Bz)-DMTr-3'-CE

ANP-1874

97

2'-O-Methyl-7-deaza 7-iodo-adenosine (N-Bz)-DMTr-3'-CEP

ANP-917196

2'-O-Methyl-7-deaza 7-Iodo-guanosine (N-iBu)-DMTr-3'-CEP

ANP-9173

99

2'-O-Methyl-7-deaza-7-propargyl (Amino- TFA)-guanosine (N-iBu)-DMTr-3'-CEP

ANP-9178

99

2'-O-Methyl-7-deaza-7-propargyl(Amino-TFA)-adenosine (N-Bz)-DMTr-3'-CEP

ANP-9176

99

2'-O-Methyl-7-deaza-adenosine (N-Bz)-DMTr-3'-CEP

ANP-5951

99

2'-O-Methyl-7-deaza-guanosine (N-iBu)-DMTr-3'-CEP

ANP-5953

99

2'-O-Methyl-cytidine (N-DMF)-DMTr-3'-CEP (Amino Modifier)

ANP-2583

97

2'-O-Methyl-Inosine-DMTr-3'-CEP

ANP-5758

96

2'-O-Methyl-P-O-ethyl-adenosine (N-Bz)-DMTr-3'-CEP

ANP-7221100

2'-O-Methyl-P-O-ethyl-adenosine (N-PAC)-DMTr-3'-CEP

ANP-7227101

2'-O-Methyl-P-O-ethyl-cytidine (N-Bz)-DMTr-3'-CEP

ANP-7222

100

2'-O-Methyl-P-O-ethyl-cytidine (N-PAC)-DMTr-3'-CEP

ANP-7228101

2'-O-Methyl-P-O-ethyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-7223

100

2'-O-Methyl-P-O-ethyl-guanosine (N-PAC)-DMTr-3'-CEP

ANP-7226

101

2'-O-Methyl-RNA Synthesis
A: CE Phosphoramidites (RNA synthesis)(1)-2'-O-Me RNA Phosphoramidites (O-Alkyl & Antisenses Oligonucleotide Modifications)(2)-2'-O-Me RNA Phosphoramidites (mild protection) (O-Alkyl & Antisenses Oligonucleotide Modifications)

B: Minor 2'-O-Me-RNA Phosphoramidites (O-Alkyl & Antisenses Oligonucleotide Modifications)

C-Backbone 2'-O-Me-RNA modificatios (O-Alkyl & Antisenses Oligonucleotide Modifications)(1)-P-O-Ethyl Phosphoramidites

207

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INDEX-1: Common Name
O-Alkyl & Antisenses Oligonucleotide Modifications
Product Name

Catalog#Page#

2'-O-Methyl-P-O-ethyl-thymidine-DMTr-3'-CEP

ANP-7224

100

2'-O-Methyl-P-O-ethyl-uridine-DMTr-3'-CEP

ANP-7225100

2'-O-Methyl-P-methyl-adenosine (N-Bz)-DMTr-3'-CEP

ANP-8551

106

2'-O-Methyl-P-methyl-cytidine (N-Ac)-DMTr-3'-CEP

ANP-8556

106

2'-O-Methyl-P-methyl-cytidine (N-iBu)-DMTr-3'-CEP

ANP-8552

106

2'-O-Methyl-P-methyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-8553

106

2'-O-Methyl-P-methyl-uridine-DMTr-3'-CEP

ANP-8554

106

2'-O-Methyl-adenosine (N-Bz)-DMTr-3'-Icaa CPG

N-7910-05/10

94

2'-O-Methyl-cytidine (N-Ac)-DMTr-3'-Icaa CPG

N-7905-05/10

94

2'-O-Methyl-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-7911-05/10

94

2'-O-Methyl-guanosine (N-DMF)-MMTr-3'-Icaa CPG

N-7914-05/10

94

2'-O-Methyl-guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-7912-05/10

94

2'-O-Methyl-uridine-DMTr-3'-Icaa CPG

N-7904-05/10

94

2'-O-Methyl-adenosine (N-PAC)-DMTr-3'-Icaa CPG

N-P7901-05/10

95

2'-O-Methyl-cytidine (N-Ac)-DMTr-3'-Icaa CPG

N-7905-05/10

95

2'-O-Methyl-cytidine (N-PAC)-DMTr-3'-Icaa CPG

N-P7902-05/10

95

2'-O-Methyl-guanosine (N-PAC)-DMTr-3'-Icaa CPG

N-P7903-05/10

95

2'-O-Methyl-5-methyl-cytidine (N-DMF)-DMTr-3'-Icaa CPG

N-1613-05/10

98

2'-O-Methyl-5-bromo-uridine-DMTr-3'-Icaa CPG

N-9011-05/10

98

2'-O-Methyl-5-iodo-uridine-DMTr-3'-Icaa CPG

N-9012-05/10

98

2'-O-Methyl-5-methyl-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-1613Bz-05/10

98

2'-O-Methyl-inosine-DMTr-3'-Icaa CPG

N-9013-05/10

98

2'-O-Methyl-thymidine-DMTr-3'-Icaa CPG

N-5601-05/10

98

2'-O-Methyl-adenosine (N-Bz)-DMTr-5'-CEP

ANP-1012

109

2'-O-Methyl 5-methyl-uridine-DMTr-5'-CEP

ANP-1017

109

2'-O-Methyl-5-methyl-cytidine (N-Bz)-DMTr-5'-CEP

ANP-1016

109

2'-O-Methyl-cytidine (N-Ac)-DMTr-5'-CEP

ANP-1019

109

2'-O-Methyl-cytidine (N-Bz)-DMTr-5'-CEP

ANP-1013

109

2'-O-Methyl-guanosine (N-iBu)-DMTr-5'-CEP

ANP-1014

109

2'-O-Methyl-uridine-DMTr-5'-CEP

ANP-1015

109

2'-O-Methyl-5-methyl-cytidine (N-Bz)-DMTr-5'-Icaa CPG

N-9916-05/10

1102'-O-Methyl-5-methyl-uridine-DMTr-5'-Icaa CPG

N-9917-05/10

1102'-O-Methyl-adenosine (N-Bz)-DMTr-5'-Icaa CPG

N-9912-05/10

1102'-O-Methyl-cytidine (N-Ac)-DMTr-5'-Icaa CPG

N-9919-05/10

1102'-O-Methyl-cytidine (N-Bz)-DMTr-5'-Icaa CPG

N-9913-05/10

1102'-O-Methyl-guanosine (N-iBu)-DMTr-5'-Icaa CPG

N-9914-05/10

1102'-O-Methyl-uridine-DMTr-5'-Icaa CPG

N-9915-05/10

110(2)-Methyl RNA Phosphonamidites (O-Alkyl & Antisenses Oligonucleotide Modifications)

D: Supports For 2'-OME RNA Synthesis (O-Alkyl & Antisenses Oligonucleotide Modifications)(1)-2'-OMe-RNA 3'-CPG (O-Alkyl & Antisenses Oligonucleotide Modifications)(2)-2'-OMe-RNA 3'-CPG (mild protection) (O-Alkyl & Antisenses Oligonucleotide Modifications)(3)-Minor 2'-OMe-RNA 3'-CPG (O-Alkyl & Antisenses Oligonucleotide Modifications)2'-O-Me 5'→ 3' RNA Synthesis (O-Alkyl & Antisenses Oligonucleotide Modifications)
A: 2'-O-Me 5'-CE RNA Phosphoramidites (O-Alkyl & Antisenses Oligonucleotide Modifications)

B: Support:2'-O-Me 5'-CPG (O-Alkyl & Antisenses Oligonucleotide Modifications)208

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INDEX-1: Common Name
O-Alkyl & Antisenses Oligonucleotide Modifications/Combiclick Chemistry
Product Name

Catalog#

Page#

2'-Fluoro-2'-deoxyadenosine (N-DMF)-DMTr-3'-CEP

ANP-9157

78

2'-Fluoro-2'-deoxyadenosine (N-Bz)-DMTr-3'-CEP

ANP-9151

78

2'-Fluoro-2'-deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-915278

2'-Fluoro-2'-deoxyguanosine (N-DMF)-DMTr-3'-CEP

ANP-9159

78

2'-Fluoro-2'-deoxyguanosine (N-iBu)-DMTr-3'-CEP

ANP-9153

78

2'-Fluoro-2'-deoxyuridine-DMTr-3'-CEP

ANP-9154

78

2'-Fluoro-2'-deoxyadenosine (N-PAC)-DMTr-3'-CEP

ANP-913179

2'-Fluoro-2'-deoxycytidine (N-Ac)-DMTr-5'-CEP

ANP-819279

2'-Fluoro-2'-deoxyguanosine (N-iPrPAC)-DMTr-3'-CEP

ANP-913479

2'-Fluoro-2'-deoxyuridine-DMTr-5'-CEP

ANP-819479

2'-Fluoro-2'-deoxyinosine-DMTr-3'-CEP

ANP-9234

80

2'-Fluoro-5-iodo-2'-deoxyuridine-DMTr-3'-CEP

ANP-923580

2'-Fluoro-5-methyl-2'-deoxycytidine (N-Ac)-DMTr-3'-CEP

ANP-923180

2'-Fluoro-5-methyl-2'-deoxycytidine (N-Bz)-DMTr-3'-CEP

ANP-923280

2'-Fluoro-5-methyl-2'-deoxyuridine-DMTr-3'-CEP

ANP-9233

80

2'-Fluoro-2'-deoxyadenosine (N-DMF)-DMTr-3'-Icaa CPG

N-1067-05

782'-Fluoro-2'-deoxyadenosine (N-Bz)-DMTr-3'-Icaa CPG

N-1058-05

782'-Fluoro-2'-deoxycytidine (N-Ac)-DMTr-3'-Icaa CPG

N-1057-05

782'-Fluoro-2'-deoxyguanosine (N-DMF)-DMTr-3'-Icaa CPG

N-1069-05

78

2'-Fluoro-2'-deoxyguanosine (N-iBu)-DMTr-3'-Icaa CPG

N-1055-05

782'-Fluoro-2'-deoxyuridine-DMTr-3'-Icaa CPG

N-1056-05

78

2'-O-Butyne-aenosine (N-Bz)-DMTr 3'-CEP

ANP-7621

108

2'-O-Butyne-cytidine (N-Bz)-DMTr-3'-CEP

ANP-7622

108

2'-O-Butyne-guanosine (N-iBu)-DMTr-3'-CEP

ANP-7623

108

2'-O-Butyne-uridine-DMTr-3'-CEP

ANP-7625

108

2'-O-Butyne-adenosine (N-Bz)-DMTr-3'-Icaa CPG

N-9611-05/10

1082'-O-Butyne-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-9612-05/10

1082'-O-Butyne-guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-9613-05/10

1082'-O-Butyne-uridine-DMTr-3'-Icaa CPG

N-9614-05/10

1082'-O-Propargyl-adenosine (N-Bz)-DMTr-3'-CEP

ANP-7751

112

2'-O-Propargyl-cytidine (N-Ac)-DMTr-3'-CEP

ANP-7756

112

2'-F RNA Synthesis (O-Alkyl & Antisenses Oligonucleotide Modifications)
A: CE Phosphoramidites (O-Alkyl & Antisenses Oligonucleotide Modifications)(1)-2'-F-RNA Monomers (O-Alkyl & Antisenses Oligonucleotide Modifications)(2)-2'-F-RNA Monomers (Ultramild) (O-Alkyl & Antisenses Oligonucleotide Modifications)

B: Minor 2'-F-RNA Monomers (O-Alkyl & Antisenses Oligonucleotide Modifications)

C: Supports (O-Alkyl & Antisenses Oligonucleotide Modifications)(1)-Support-3'-CPG (O-Alkyl & Antisenses Oligonucleotide Modifications)2'-O-Butyne RNA Synthesis
A: 2'-O-Butyne-RNA Phosphonamidites (O-Alkyl & Antisenses Oligonucleotide Modifications)

B: Supports:2'-O-Butyne-RNA 3'-CPG (O-Alkyl & Antisenses Oligonucleotide Modifications)

RNA:2'-O-Propargyl RNA Synthesis (CombiclickTM Chemistry)
A: 2'-O-Propargyl RNA Phosphoramidites (CombiclickTM Chemistry)2'-O-Propargyl-cytidine (N-Bz)-DMTr-3'-CEP

ANP-7752

112

2'-O-Propargyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-7753

112

2'-O-Propargyl-inosine-DMTr-3'-CEP

ANP-6191

112

2'-O-Propargyl-uridine-DMTr-3'-CEP

ANP-7754

112

209

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INDEX-1: Common Name
O-Alkyl & Antisenses Oligonucleotide Modifications/Combiclick Chemistry
Product Name

Catalog#Page#

2'-O-Propargyl-abasic-DMTr-3’-CEP; 2'-O-Propargyl-1,1 dihydro-β-D-ribose-DMTr-3’-CEP

ANP-9782

114

2'-O-Propargyl-abasic-DMTr-3’-Icaa CPG

N-9784-05/10

114

Ara-Propargyl-inosine-DMTr-3’-CEP

ANP-9851

114

TM

B: 2'-O-Propargyl RNA:Minor Phosphoramidites (Combiclick

Chemistry)

C: Supports-2'-O-Propargyl RNA 3'-CPG (CombiclickTM Chemistry)2'-O-Propargyl-adenosine (N-Bz) DMTr 3'-Icaa CPG

N-8910-05/10

112

2'-O-Propargyl-cytidine (N-Ac) DMTr 3'-Icaa CPG

N-8960-05/10

112

2'-O-Propargyl-cytidine (N-Bz) DMTr 3'-Icaa CPG

N-8920-05/10

112

2'-O-Propargyl-guanosine (N-iBu) DMTr 3'-Icaa CPG

N-8930-05/10

112

2'-O-Propargyl-inosine DMTr 3'-Icaa CPG

N-8970-05/10

112

2'-O-Propargyl-uridine DMTr 3'-Icaa CPG

N-8940-05/10

112

2'-O-Hexyne-inosine-DMTr-3’-CEP

ANP-9852

112

2'-O-Hexyne-1,1 dihydro-β-D-ribose-DMTr-3’-CEP

ANP-9781

112

3'-O-Methyl-adenosine (N-Bz)-DMTr-2'-CEP

ANP-2901

102

3'-O-Methyl-cytidine (N-Ac)-DMTr-2'-CEP

ANP-2906

102

RNA:2'-O-Hexyne RNA Synthesis (CombiclickTM

Chemistry)

A: 2'-O-Hexyne RNA Phosphoramidites (CombiclickTM Chemistry)

RNA:3'-O-Alkyl RNA Synthesis
A: 3'-O-Alkyl RNA phosphoramidites(1)-3'-O-Methyl-RNA Phosphoramidites (O-Alkyl & Antisenses Oligonucleotide Modifications)3'-O-Methyl-cytidine (N-Bz)-DMTr-2'-CEP

ANP-2902

102

3'-O-Methyl-guanosine (N-iBu)-DMTr-2'-CEP

ANP-2903

102

3'-O-Methyl-inosine-DMTr-2'-CEP

ANP-2905

102

3'-O-Methyl-thymidine-DMTr-2'-CEP

ANP-2907

102

3'-O-Methyl-uridine-DMTr-2'-CEP

ANP-2904102(2)-3'-O-Propargyl RNA Phosphoramidites (CombiclickTM Chemistry)3'-O-Propargy-cytidine (N-Ac)-DMTr-2'-CEP

ANP-9759

113

3'-O-Propargyl-adenosine (N-Bz)-DMTr-2'-CEP

ANP-9751

113

3'-O-Propargyl-cytidine (N-Bz)-DMTr-2'-CEP

ANP-9752

113

3'-O-Propargyl-guanosine (N-iBu)-DMTr-2'-CEP

ANP-9753

113

3'-O-Propargyl-uridine-DMTr-2'-CEP

ANP-9754

113

N-8810-05/10

102

B:3'-O-Alkyl RNA Supports(1)-Supports:3'-O-ME-RNA 2'-CPG (O-Alkyl & Antisenses Oligonucleotide Modifications)3'-O-Methyl-adenosine (N-Bz)-DMTr-2'-Icaa CPG
3'-O-Methyl-cytidine (N-Bz)-DMTr-2'-Icaa CPG

N-8811-05/10

102

3'-O-Methyl-guanosine (N-iBu)-DMTr-2'-Icaa CPG

N-8812-05/10

102

3'-O-Methyl-inosine-DMTr-2'-Icaa CPG

N-8814-05/10

102

3'-O-Methyl-uridine-DMTr-2'-Icaa CPG

N-8813-05/10

102

3'-O-Propargyl-adenosine (N-Bz)-DMTr-2'-Icaa CPG

N-9881-05/10

113
113

(2)-Supports:3'-O-Propargyl RNA 2'-CPG (CombiclickTM Chemistry)3'-O-Propargyl-cytidine (N-Ac)-DMTr-2'-Icaa CPG

N-9889-05/10

3'-O-Propargyl-cytidine (N-Bz)-DMTr-2'-Icaa CPG

N-9882-05/10

113

3'-O-Propargyl-guanosine (N-iBu)-DMTr-2'-Icaa CPG

N-9883-05/10

113

3'-O-Propargyl-uridine-DMTr-2'-Icaa CPG

N-9884-05/10

113

210

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INDEX-1: Common NameRNA Synthesis
Product Name

Catalog#Page#

2,2'-Anhydro-uridine-DMTr-3'-CEP

ANP-4876

74

2-Amino-adenosine-DMTr-3'-CEP, (2,6-Diamino Purine DMTr-3'-CEP)

ANP-8613

81

2-Amino-purine (N-DMF)-DMTr-3'-CEP

ANP-8619

81

2-Amino-purine (N-iBu)-DMTr-3'-CEP

ANP-8617

81

2-One-pyridine-DMTr-3'-CEP; Zebularine CEP

ANP-8611

76

4-Triazolyl-uridine-DMTr-3'-CEP

ANP-916776

4-Thio-uridine-DMTr-3'-CEP

ANP-810176

2-Thio-uridine-DMTr-3'-CEP

ANP-9216

76

5-Bromo-cytidine (N-Bz)-DMTr-3'-CEP

ANP-5648

84

5-Bromo-uridine-DMTr-3'-CEP

ANP-7411

84

5-Fluoro-2'-deoxyuridine-DMTr-3'-CEP

ANP-615484

5-Iodo-cytidine (N-Bz)-DMTr-3'-CEP

ANP-721284

5-Iodo-uridine-DMTr-3'-CEP

ANP-7412

84

5-Methyl-cytidine (N-Bz)-DMTr-3'-CEP

ANP-5675

74

8-Bromo-adenosine (N-DBF)-DMTr-3'-CEP

ANP-7111

85

8-Bromo-adenosine (N-DMF)-DMTr-3'-CEP

ANP-711285

8-Bromo-guanosine (N-DMF)-DMTr-3'-CEP

ANP-711385

8-methyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-627473

8-Oxo-7-allyl-guanosine (N-iBu)-DMTr-3'-CEP

ANP-942285

8-Oxo-guanosine (N-DMF)-DMTr-3'-CEP

ANP-9420

85

Inosine-DMTr-3'-CEP

ANP-5680

74

N -Methyl-thymidine-DMTr-3'-CEP

ANP-7461

73

N3-Methyl-uridine-DMTr-3'-CEP

ANP-7451

73

ANP-7441

73

N , N -Dimethyl-adenosine-5'-DMTr-3'-CEP

ANP-8626

75

N6-Benzyl-adenosine-DMTr-3'-CEP

Minor RNA Bases
A: Minor RNA Phosphoramidites(1)-TBDMS Protected RNA Phosphoramidites

3

3

N -Thiobenzoylethyl-uridine-DMTr-3'-CEP
6

6

ANP-861475

6

ANP-861575

4

ANP-416575

N -isopentenyl-adenosine-DMTr-3'-CEP
N -Ethyl-cytidine-DMTr-3'-CEP
Purine-riboside-DMTr-3'-CEP; Nebularine CEP

ANP-8616

81

Thymidine-DMTr-3'-CEP

ANP-7511

74

5,6-Dihydro-uridine-DMTr-3'-CEP

ANP-6066

87

7-Deaza-7-cyano-adenosine (N-Bz)-DMTr-3'-CEP

ANP-7306

83

7-Deaza-adenosine (N-Bz)-DMTr-3'-CEP; Tubercidin

ANP-7101

83

7-Deaza-guanosine (N-Ac)-DMTr-3'-CEP

ANP-7302

83

7-Deaza-guanosine (N-iBu)-DMTr-3'-CEP

ANP-7301

83

7-Deaza-guanosine (N-iBu)-DMTr-5'-CEP

ANP-7102

83

Iso-cytidine (N-DBF)-DMTr-3'-CEP

ANP-7715

86

Iso-guanosine (N-DBF)-DMTr-3'-CEP

ANP-5988

86

Adenosine (N-Bz)-DMTr-2'-CEP

ANP-5681

72

Cytidine (N-Ac)-DMTr-2'-CEP

ANP-5686

72

Cytidine (N-Bz)-DMTr-2'-CEP

ANP-5682

72

Guanosine (N-iBu)-DMTr-2'-CEP

ANP-5683

72

Inosine-DMTr-2'-CEP

ANP-5687

72

Uridine-DMTr-2'-CEP

ANP-5684

72

211

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INDEX-1: Common NameRNA Synthesis
Product Name

Catalog#

Page#

P-O-Ethyl-adenosine (N-PAC)-DMTr-3'-CEP

ANP-4131

89

P-O-Ethyl-cytidine (N-PAC)-DMTr-3'-CEP

ANP-4132

89

P-O-Ethyl-guanosine (N-PAC)-DMTr-3'-CEP

ANP-4133

89

P-O-Ethyl-uridine-DMTr-3'-CEP

ANP-4134

89

Pseudo-uridine-DMTr-3'-CEP

ANP-8612

76

β-L-Adenosine (N-Bz)-DMTr-3'-CEP

ANP-4841

88

β-L-Cytidine (N-Ac)-DMTr-3'-CEP

ANP-4846

88

β-L-Cytidine (N-Bz)-DMTr-3'-CEP

ANP-4842

88

β-L-Guanosine (N-iBu)-DMTr-3'-CEP

ANP-4843

88

β-L-Thymidine-DMTr-3'-CEP

ANP-4844

88

β-L-Uridine-DMTr-3'-CEP

ANP-4845

85

2'-Amino(TFA)-cytidine (N-Bz)-DMTr-3'-CEP

ANP-5322

82

2-Amino-2'-Amino (TFA)-uridine-DMTr-3'-CEP

ANP-9403

82

5'-Amino (TFA)-cytidine (N-Ac)-3'-CEP

ANP-9405

82

2',3'-Diacetyl-guanosine (N-iBu)-5'-CEP

ANP-6156

87

2',3'-Diacetyl-uridine-5'-CEP

ANP-615587

2,2'-Anhydro-uridine-DMTr-3'-Icaa CPG

N-9810-05/10

74

2-Amino-adenosine-DMTr-3'-Icaa CPG

N-9040-05/10

81

2-Amino-purine-DMTr-3'-Icaa CPG

N-9070-05/10

81

2-One-pyridine-DMTr-3'-Icaa CPG; Zebularine CPG

N-9020-05/10

76

5-Bromo-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-9844-05/10

85

5-Bromo-uridine-DMTr-3'-Icaa CPG

N-9818-05/10

85

5-Fluoro-uridine-DMTr-3'-Icaa CPG

N-9832-05/10

85

5-Iodo-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-9893-05/10

85

5-Iodo-uridine-DMTr-3'-Icaa CPG

N-9809-05/10

85

5-Methyl-cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-9822-05/10

74

7-Deaza-adenosine (N-Bz)-DMTr-3'-Icaa CPG; Tubercidin CPG

N-9897-05/10

83

7-Deaza-guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-9895-05/10

83

8-Bromo-adenosine (N-DBF)-DMTr-3'-Icaa CPG

N-9812-05/10

85

8-Methyl-guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-9909-05/10

73

Adenosine (N-Ac)-DMTr-3'-Icaa CPG

N-6681-05/10/20

58

Adenosine (N-Bz)-DMTr-3'-Icaa CPG

N-6101-05/10/20

58

Cytidine (N-Ac)-DMTr-3'-Icaa CPG

N-6106-05/10/20

58

Cytidine (N-Bz)-DMTr-3'-Icaa CPG

N-6102-05/10/20

58

Guanosine (N-iBu)-DMTr-3'-Icaa CPG

N-6103-05/10/20

58

Inosine-DMTr-3'-Icaa CPG

N-8370-05/10

74

Iso-Cytidine (N-DBF)-DMTr-3'-Icaa CPG

N-9712-05/10

86

Iso-Guanosine (N-DBF)-DMTr-3'-Icaa CPG

N-9827-05/10

86

N-9816-05/10

73

β-L-RNA-Spiegelmers(2)Amino TFA Protected RNA Phosphoramidites(3)-Acetyl Protected RNA Phosphoramidites

B: Supports-Minor-RNA-TBDMS Protected 3'-CPG(1)-TBDMS Protected RNA 3'-CPG

3

N -Methyl-thymidine-DMTr-3'-Icaa CPG

212

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INDEX-1: Common NameRNA Synthesis/Modifiers & Labelling
Product Name

Catalog#Page#

N -Methyl-uridine-DMTr-3'-Icaa CPG

N-9814-05/10

73

N3-Thiobenzoylethyl-uridine-DMTr-3'-Icaa CPG

3

N-9828-05/10

73

4

N-9824-05/1075

6N-9050-05/10

75

6

N -Isopentenyl-adenosine-DMTr-3'-Icaa CPG

N-9060-05/10

75

N -Ethyl-cytidine-DMTr-3'-Icaa CPG
N -Benzyl-adenosine-DMTr-3'-Icaa CPG

Pseudo-uridine-DMTr-3'-Icaa CPG

N-4617-05

76-77

Purine-riboside-DMTr-3'-Icaa CPG

N-9080-05/10

81

Thymidine-DMTr-3'-Icaa CPG

N-8477-05/10

74

Uridine-DMTr-3'-Icaa CPG

N-6104-05/10/20

58

β-L- Uridine -DMTr-3'-Icaa CPG

N-4694-05/10

88

β-L-Adenosine (N-Bz)-DMTr 3'-Icaa CPG

N-4691-05/10

88

β-L-Cytidine (N-Ac)-DMTr 3'-Icaa CPG

N-4696-05/10

88

β-L-Cytidine (N-Bz)-DMTr 3'-Icaa CPG

N-4692-05/10

88

β-L-Guanosine (N-iBu)-DMTr 3'-Icaa CPG

N-4693-05/10

88

β-L-Thymidine-DMTr 3'-Icaa CPG

N-4695-05/10

88

2-Amino-2'-amino (TFA)-uridine-DMTr-3'-Icaa CPG

N-9010-05/10

82

2'-Amino (TFA)-cytidine (N-Bz) CPG

N-9015-05/10

82

3'-L-O-Methyl-tyrosine-puromycin-2'- Icaa CPG

N-1976-05/10

74

Puromycin 2'-succinyl Icaa CPG

N-1971-05/10

74

Anhydrous Ammonia in Ethanol Solution (20% ammonia by wt in absolute ethanol)

CSS-3268

91

Fluoride Ion Removal Solution

CSS-6634

91

RNA Purification Cartridges

CSS-5272-02

91

RNA Purification Cartridges

CSS-5272-10

91

RNA Purification Kit

CSS-5232-02

91

RNA Purification Kit

CSS-5232-10

91

RNA Purification Kit

CSS-3268

91

RNA Purification Kit

CSS-5272

91

RNA Purification Kit

CSS-6634

91

RNA Purification Kit

CSS-5232

91

Tetra butyl Ammonium Fluoride (1 M Sol in THF)

CSS-4356

91

CLP-717112, 129

5'- Phosphorylation; Bis-cyanoethyl-N,N-diisopropyl CEP

CLP-1454

118

3'-Phosphate-ON Icaa CPG

N-9977-05/10/20

118

5-Phosphorylation (generates DMTr color)-(5-Phosphate-ON Reagent)

CLP-1544

118

3'-Amino (Fmoc)-modifier DMTr CEP

CLP-1661

122

2,7-di-tert-butyl-(Fmoc)-amino-butyrylglyceryl- Phosphoramidite

CLP-1666

121

3'-Amino (Fmoc)-modifier-C3 CPG

N-9750-05/10

122

3'-Amino (Fmoc)-modifier-C7 CPG

N-1005-05/10

123

3'-Amino (TFA)-modifier-spacer 6 Polymeric Support

N-1004-13

122

3'-Amino (TFA)-modifier-spacer 7-Icaa CPG

N-1004-05/10

122(2)-Amino (TFA) Protected RNA 3'-CPG

Puromycin Supports

RNA Synthesis: Purification Kit

Levulinyl Deprotection Solution
Levulinyl Deprotection Solution

Modifiers
A: Chemical Phosphorylation and Supports

B: Amino Modifiers and Supports

213

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INDEX-1: Common Name
Modifiers & Labelling
Product Name

Catalog#Page#

3'-Amino (trityl)-modifier-dT CPG

N-8024-05/10

122

3'-Amino-modifier-C6-phthalamido CPG

N-8217-05/10

123

5'-Amino (Fmoc)-modifier-C6 CEP

CLP-1586

121

5'-Amino (Fmoc)-modifier-C7 CEP

CLP-1662

121

5'-Amino (MMTr)-modifiers-C6 CEP

CLP-1563

119

5'-Amino (TFA)-modifier-C12 CEP

CLP-1575

121

5'-Amino (TFA)-modifiers-C4 CEP

CLP-1453

119

5'-Amino (TFA)-modifiers-C5 CEP

CLP-1357

119

5'-Amino (TFA)-modifiers-C6 CEP

CLP-1553

119

5'-Amino(MMT)-modifier-C12 CEP

CLP-1585

121

Amino-modifier-13-dC CE; deoxy Cytidine N4 Amino Linker CEP

CLP-1329

120

Amino-modifier-13-dC CPG

N-6052-05/10

122

Amino-modifier-C6-dT CPG

N-6054-05/10

122

Amino-modifier-C6-phthalamido CEP

CLP-1328

123

Amino-modifiers-C6-dT CEP

CLP-1501

122

DMT-free Amine C-7 Icaa CPG

N-1577-05/10

119

ssR-Me Amino Linker

CLP-1131

120

ssR-H Amino Linker

CLP-1132

120

Butyl CPG (for 3’-Butanol Spacer)

N-7178-05/10

124

DMTr-Butane-diol phosphoramidite; C4 Spacer

CLP-9775

124

DMTr-Butanol Polymeric Support

N-9168-05/10

124

DMTr-C3 lcaa CPG

N-1089-05/10

124

DMTr-Dodecane-diol phosphoramidite; C12 Spacer

CLP-1114

124

DMTr-Ethane-diol phosphoramidite; C2 Spacer

CLP-2250

124

DMTr-Hexa-Ethyloxy-glycol phosphoramidite; Spacer 18

CLP-9765

125

DMTr-Hexane-diol phosphoramidite; C6 Spacer

CLP-1120

124

DMTr-Nonane-diol phosporamidite; C9 Spacer

CLP-9009

124

DMTr-Propane-diol phosphoramidite; C3 Spacer

CLP-9908

124

DMTr-Tetraethyloxy-glycol phosphoramidite; Spacer 12

CLP-1368

125

DMTr-Triethyloxy-glycol phosphoramidite; Spacer 9

CLP-1113

125

Glyceryl CPG; 1-DMTr-2-OAc-Glyceryl Succinate attached to lcaa CPG

N-7175-05/10

124

Palmitoyl Polymeric Support

N-9821-03

125

Pentane diol; C5 Spacer

CLP-9901

126

Polyethyleneglycol 2000 CEP

CLP-2119

125

Polyethylenglycol 4500 CEP, (Avg. M.W.~4500)

CLP-3118

125

Polyethylenglycol 4500 CEP, (Avg. M.W.~4500)

CLP-3119125

TOM C6 CEP

CLP-8508

125

3'-Thiol-modifiers-C3-S-S CPG

N-9976-05/10

126

5'-Thiol (trityl)-modifiers-C6 CEP, 5’-Thiol (trityl)-modifiers-C6 CPG

CLP-5888, N-9978-05/10

126

5'-Thiol (trityl)-modifiers-dC (N-Ac) CEP

CLP-8509

127

5'-Thiol C3 SS modifier

CLP-8409

127

5'-Thiol-modifiers C6 CEP; 1-Thiobenzoyl-hexanol-6 Cyanoethyl CEP

CLP-9773

127

Thiol-modifiers-C6-S-S CEP

CLP-8506

126

Thiol-modifiers-C6-S-S CPG; DMTr-C6-Disulfide Solid Support

N-9987-05/10

126

Cyclic Dithiolane Disulfide Phosphoramidite, Cyclic Dithiolane Disulfide lcaa CPG

CLP-8407, N-8408-05/10

127

C: Spacer Modifiers and Supports

D: Thiol Modifiers and Supports

214

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INDEX-1: Common Name
Modifiers & Labelling
Product Name

Catalog#

Page#

Asymmetrical Branching CEP

CLP-7169

129

Asymmetrical Branching lcaa CPG

N-7170-05/10

129

NPPOC-DMT Asymmetrical Branching CEP

CLP-7178

129

Symmetrical Branching CEP

CLP-5215

129

Symmetrical Branching Polymeric Support

N-7173-05

129

Symmetrical Branching Support lcaa CPG

N-5216-05/10

129

Biotin (BB) -TEG CEP

CLP-1518

128

Biotin (BB)TM CEP

CLP-1517

128

Biotin (BB)TM CPG; D-(+) Biotin lcaa CPG

N-9162-05

128

Biotin dT CEP

CLP-1502

128

Biotin TEG lcaa CPG

N-1506-05

128

Psoralen C-18 Hexaethyloxyglycol CEP

CLP-6642

139

Psoralen C-2 CEP

CLP-6647

138

Psoralen C-4 CEP

CLP-6648

138

Psoralen C-4 lcaa CPG

N-9081-05/10

139

Psoralen C-6 CEP

CLP-6641

138

Psoralen CEP

CLP-6644

138

Psoralen Support

N-9375-05

139

3'-Fluorescein-dT CPG

N-5122-05

1353'-Fluorescein-Icaa CPG

N-9979-05

135

5-FAM CPG

N-9969-05

136

5-Fluorescein CEP

CLP-4282

135

5'-Fluorescein CPG, 6-FAM lcaa CPG (DMTr)

N-9986-05

135

5'-Fluorescein-phosphoramidite; 6-FAM

CLP-9777

134

5'-Hexachloro-fluorescein Phosphoramidite

CLP-9778

134

5'-Tetrachloro-fluorescein Phosphoramidite

CLP-9779

134

6-FAM CPG

N-9985-05

136

DMTr-5-FAM Phosphoramidite

CLP-9789

136

DMTr-6-FAM Phosphoramidite

CLP-9780

136

Etheno-adenosine 2'/3'-lcaa CPG

N-9091-05/10

133

Etheno-adenosine 2'-TBDMS 3'-lcaa CPG

N-9191-05/10

133

Etheno-adenosine CEP; Etheno-2'-O-TBDMS Adenosine CEP

CLP-9191

133

Etheno-cytidine 2'/3'-lcaa CPG

N-9092-05/10

133

Etheno-cytidine 2’-TBDMS 3’-lcaa CPG

N-9192-05/10

133

Etheno-cytidine CEP; Etheno-2'-O-TBDMS Cytidine CEP

CLP-9192

133

Etheno-deoxyadenosine 3'-lcaa CPG

N-9113-05/10

133

Etheno-deoxyadenosine CEP

CLP-9181

133

Etheno-deoxycytidine 3'-lcaa CPG

N-9114-05/10

133

Etheno-deoxycytidine CEP

CLP-9182

133

Fluorescein dT CEP

CLP-9905

135

Hexachloro-fluorescein Cyclohexyl CEP

CLP-1527

134

Tetrachloro-fluorescein Cyclohexyl CEP

CLP-1526

134

E: Branching phosphoramidites and Supports

Labelling
A: Biotin Labelling

B: Psoralen labelling

C: Fluorescein Labelling

215

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INDEX-1: Common Name
Modifiers & Labelling/Nucleosides
Product Name

Catalog#

Page#

DNP-TEG CEP

CLP-9907

132

DNP-TEG-lcaa-CPG

N-9127-05

132

Naphthyl Red phosphoramidite

CLP-6643

132

5'-TAMRA CEP

CLP-9066

137

6-TAMRA Supports & Columns

N-2255-05

137

Cocktail for TAMRA

RN-8561137

N4-6-TAMRA Cytidine-3’- lcaa CPG

N-2145-05

137

Rox Supports & Columns

N-2246-05

137

3'-Dabcyl CEP

CLP-1522

132

3'-Dabcyl CPG

N-9756-05/10

132

Dabcyl Succinyl diamido Polymeric Support

N-9756-PF

132

Dabsyl-dT CEP

CLP-9906

132

Cholesterol (Plant) TEG CEP

CLP-2795

131

Cholesterol (TEG) CEP (Will Generate DMT color)

CLP-2703

131

Cholesterol C4 lcaa CPG

N-9267-05

131

Cholesterol TEG lcaa CPG

N-9166-05

131

TEG Cholesterol (Tetra Ethylene Glycol) CEP

CLP-2704131

TEG Cholesterol (Tetra Ethylene Glycol) Phosphonate
TEG Cholesterol (Tetra Ethylene Glycol) -H- Phosphonate TEA Salt"

CLP-2705

131

CLP-2706

130

5'-Carboxyl Group Generating Reagent; Thymidine-Succinyl Hexamide CEP

CLP-2244130

C-5 Carboxy Introducing Amidite; Deoxy Uridine 5-Methylacrylate CEP

CLP-2842

130

Hexane-6-Carboxyamido (p-benzaldehyde)- 1-ol CEP

CLP-2243130

Undecanoic CEP

CLP-8146

130

N-1971-05/1076

2'-β-D-Deoxyadenosine Monohydrate

DN-10011402'-β-D-Deoxycytidine (Free Base)

DN-1002fb

1402'-β-D-Deoxycytidine Monohydrate

DN-10021402'-β-D-Deoxyguanosine Monohydrate

DN-10031402'-β-D-Deoxyinosine

DN-40021422'-β-D-Deoxyuridine

DN-6373

142

Thymidine Monohydrate

DN-1004140

2',3'-β-D-Dideoxyadenosine

DDN-1844

141

2',3'-β-D-Dideoxycytidine

DDN-1868

141

D: DNP Labelling

E: Rhodamine (Tamra) labelling

F: Dabcyl Labelling

G: Cholesterol

H: Tocopherol(+)-a-Tocopherol-Phosphoramidite
I: Carboxyl Generating reagents

J: Puromycin Labelling
Puromycin-2'-Succinyl Icaa CPG

Nucleoside
Unprotected mononucleosides
I-Unprotected deoxy mononucleosides
A: Deoxy Nucleosides

B: Dideoxy nucleosides

216

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#Page#

2',3'-β-D-Dideoxyguanosine

DDN-1882

141

2',3'-β-D-Dideoxyinosine

DDN-1893

141

2',3'-β-D-Dideoxyuridine

DDN-1892

141

3'-β-D-Deoxythymidine

DDN-1883

141

Alpha-D-2'-deoxyadenosine

DN-6351

146

Alpha-D-2'-deoxycytidine

DN-6352

146

Alpha-D-2'-deoxyguanosine

DN-6353

146

Alpha-D-thymidine

DN-6354

146

2-Amino-β-L-2'-deoxyadenosine

DN-8331146

β-L-2'-deoxycytidine

DN-8232146

β-L-2'-deoxydenosine

DN-8231146

β-L-2'-deoxyguanosine

DN-8233146

β-L-2'-deoxyuridine

DN-8235

146

β-L-thymidine

DN-8234

146

7-Deaza-2'-deoxyadenosine

DN-1143148

7-Deaza-2'-deoxyguanosine

DN-4567148

7-Deaza-2'-deoxyInosine

DN-1145

148

N1-Methyl-2'-deoxyadenosine

DN-1597

144

N1-Methyl-2'-deoxyguanosine

C: Alpha deoxy nucleosides

D: L-deoxy nucleosides

E: 7-deaza deoxy Nucleosides

F: N-Alkylated Nucleosides

DN-1598

144

3

DN-6493

144

3

N -Methyl-2'-deoxyuridine

DN-6495

144

N3-Methyl-thymidine

DN-1599

144

N -Ethyl-2'-deoxycytidine

DN-7474

144

N4-Methyl-2'-deoxycytidine

DN-2016

144

DN-2015

144

5-Bromo-2'-deoxyuridine

DN-1136

143

5-Bromo-2'-deoxycytidine

Dn-6496

143

5-Iodo-2'-deoxycytidine

DN-1181

143

5-Iodo-2'-deoxyuridine

DN-1180

143

7-Iodo-7-deaza-2'-deoxyadenosine

DN-2561

143

7-Iodo-7-deaza-2'-deoxyguanosine

DN-2563

143

8-Bromo-2'-deoxyadenosine

DN-1182

143

8-Bromo-2'-deoxyguanosine

Dn-1203143

Etheno-2'-deoxyadenosine

DN-4895

142

Etheno-2'-deoxycytidine

DN-4252

142

4-Thio-2'-deoxyuridine

DN-1263

145

4-Thio-thymidine

DN-1781

145

6-Thio-2'-deoxyguanosine

DN-1269

145

N -Methyl-2'-deoxycytidine

46

N -Methyl-2'-deoxyadenosine
G: Halogenated Nucleosides

H: Etheno Nucleosides

I: Thio Nucleosides

217

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#

Page#

5-Methyl-2'-deoxycytidine

DN-2013142

5-Propynyl-2'-deoxycytidine

DN-1541145

5-Propynyl-2'-deoxyuridine

DN-1846145

2'-Deoxynebularine; 2’-deoxy purine riboside

DN-1266

147

5-Aza-2'-deoxycytidine; 4-Amino-1-(2-deoxy-ß-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

DN-1771

147

5-Iodo 2',3'-dideoxycytidine

DDN-1731

141

5-Iodo-2',3'-dideoxyuridine

DDN-1884141

7-Deaza-2',3'-dideoxyadenosine

DDN-3864

141

7-Deaza-2',3'-dideoxyguanosine

DDN-1863

141

7-Iodo-7-deaza-2',3'-dideoxyadenosine

DDN-3818

141

7-Iodo-7-deaza-2',3'-dideoxyguanosine

DDN-3819

141

7-Deaza-O6-methyl-2'-deoxyguanosine

DN-1147

148

8-Oxo-2'-deoxyguanosine

DN-1205

142

DN-2019

145

DN-1267

147

DN-1265

147

DN-1774

147

Adenosine

RP-1183

149

Cytidine

RP-1184

149

Guanosine

RP-1185

149

InosineRP-1187

149

Ribothymidine, 5-Methyl-ribouridine

RP-1188

149

UridineRP-1186

149

2'-Fluoro-2'-deoxyadenosine

RP-12201502'-Fluoro-2'-deoxycytidine

RP-1218150

2'-Fluoro-2'-deoxyguanosine

RP-1219150

2'-Fluoro-2'-deoxyuridine

RP-1217150

β-L-Adenosine

RP-9031154

β-L-Cytidine

RP-9032

154

β-L-Guanosine

RP-9033

154

β-L-Inosine

RP-9036

154

β-L-Thymidine

RP-9035

154

β-L-Uridine

RP-9034

154

J: 5-Alkyl Nucleosides

K: Modified Base Nucleosides

L: Halogenated and deaza halogenated dideoxy Nucleosides

M: 8-Oxo & O6 substituted Guanosine

6

O -(Carboxymethyl)-2'-deoxyguanosine (Calcium Salt)
N: 3'-Levulinyl Nucleoside
3'-Levulinyl-2'-deoxyguanosine
O: 2'-Amino Nucleoside
2'-Amino-2'-deoxycytidine
P: Azido deoxy Nucleoside
3'-Azido-3’-deoxythymidine; Zidovudine; Retrovir
II-Unprotected ribo mononucleosides
A: Ribo Nucleosides

B: 2'-Fluoro deoxy nucleosides

C: L-ribo nucleosides

218

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#Page#

7-Deaza-adenosine (Tubercidin)

RP-2312154

7-Deaza-guanosine

RP-2313154

7-Deaza-inosine

RP-2314154

2'-O-Methyl-adenosine

RP-1901155

2'-O-Methyl-cytidine

RP-1902155

2'-O-Methyl-guanosine

RP-1903155

2'-O-Methyl-inosine

RP-1906155

2'-O-Methyl-thymidine

RP-1908155

2'-O-Methyl-uridine

RP-1904155

2'-O-Allyl-adenosine

RP-3511157

2'-O-Allyl-cytidine

RP-3512157

2'-O-Allyl-guanosine

RP-3513157

2'-O-Allyl-uridine

RP-3514157

2'-O-Propargyl-adenosine

RP-3401158

2'-O-Propargyl-cytidine

RP-3402158

2'-O-Propargyl-guanosine

RP-3403158

2'-O-Propargyl-uridine

RP-3404

158

3'-O-Methyl-5-methyl-cytidine

RP-2916156

3'-O-Methyl-adenosine

RP-2911156

3'-O-Methyl-cytidine

RP-2912156

3'-O-Methyl-guanosine

RP-2913156

3'-O-Methyl-inosine

RP-2915156

3'-O-Methyl-uridine

RP-2914156

3'-O-Allyl-adenosine

RP-3111157

3'-O-Allyl-cytidine

RP-3112157

3'-O-Allyl-guanosine

RP-3113157

3'-O-Allyl-uridine

RP-3114157

3'-O-Propargyl-adenosine

RP-3301

158

3'-O-Propargyl-cytidine

RP-3302

158

3'-O-Propargyl-guanosine

RP-3303158

3'-O-Propargyl-uridine

RP-3304

158

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Aadenosine

RP-8871

159

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Cytidine

RP-8872

159

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine

RP-8873

159

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Uridine

RP-8874

159

D: 7-Deaza ribo Nucleosides

E: 2'-O-Methyl ribo nucleosides

F: 2'-O-Allyl ribo Nucleosides

G: 2'-O-Propargyl ribo Nucleosides

H: 3'-O-Methyl ribo Nucleosides

I: 3'-O-Allyl ribo Nucleosides

J: 3'-O-Propargyl ribo Nucleosides

K: 5',3'-Tetraisopropyl disiloxane ribo Nucleoside219

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#Page#

2,6-Diamino-Purine-riboside

RP-8334150

2-Amino-Purine-riboside

RP-8335150

2,2'-O-Anhydro-5-methyl-cytidine

RP-4808153

2,2'-O-Anhydro-cytidine (HCl Salt), (Beta-D-O-2,2’-Cyclocytidine Ancitabine)

RP-3765

153

2,2'-O-Anhydro-uridine (HCl Salt), (Beta-D-O-2,2’-Cyclouridine)

RP-4807

153

Etheno-adenosine

RP-2310152

Etheno-cytidine

RP-2311152

L: Modified Base ribo Nucleosides

M: 2,2’-Anhydro ribo Nucleosides

N: Etheno ribo nucleosides

O: N-alkylated ribo nucleosides
RP-2317152

3

RP-1034

152

6

N -Dimethyl-adenosine

RP-2017149

N6-Palmitoy-adenosine

RP-1041152

N3-Methyl-cytidine
N -Methyl-uridine

P: 5-Alkyl ribo nucleosides
5-Methyl-cytidine

RP-1832

149

5-Propynyl-cytidine

RP-1546152

5-Propynyl-uridine

RP-1842

152

Ara-5-methyl-cytidine

RP-1835

149

Ara-7-deaza-guanosine

RP-4311

154

Uridine-arabinose

RP-2325

149

4'-Thio-uridine

RP-2304150

8-Thio-guanosine

RP-1190150

6-Chloro-inosine; 6-Chloropurine-riboside

RP-6649

150

5-Bromo-cytidine

RP-1215151

5-Bromo-uridine

RP-1192

151

5-Iodo-cytidine

RP-1221151

5-Iodo-uridine

RP-1089

151

7-Iodo-7-deaza-adenosine

RP-2316154

8-Bromo-adenosine

RP-1214151

8-Bromo-guanosine

RP-1216151

2'-O-Methyl-5-iodo-uridine

RP-1905155

2'-O-Methyl-5-methyl-cytidine

RP-1907155

2'-O-Methyl-5-propynyl-cytidine

RP-1548156

2'-O-Methyl-5-propynyl-uridine

RP-1856

156

2'-O-Methyl-N6-dimethyl-adenosine

RP-3901163

β-L-2'-O-Methyl-2-amino-adenosine

RP-3902155

β-L-2'-O-methyl-uridine

RP-1909155

RP-2916

156

Q: Sustituted Ara Nucleosides

R: Thio Ribo Nucleosides

S: Halogenated ribo nucleosides

T: Sustituted 2'-O-Methyl ribo nucleoside

U: Sustituted 3'-O-Methyl ribo nucleoside
3'-O-Methyl-5-methyl-cytidine

220

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#

Page#

DN-1266147

2'-Deoxyadenosine (N-Bz)

PM-1101160

2'-Deoxyadenosine (N-DMF)

PM-1588160

2'-Deoxyadenosine (N-PAC)

PM-9996160

2'-Deoxycytidine (N-Ac)

PM-1105160

2'-Deoxycytidine (N-Bz)

PM-1102160

2'-Deoxycytidine (N-iBu)

PM-1104160

2'-Deoxycytidine (N-PAC)

PM-9997160

2'-Deoxyguanosine (N-DMF)

PM-3183160

2'-Deoxyguanosine (N-iBu)

PM-1103160

2'-Deoxyguanosine (N-PAC)

PM-9998

160

5’-Levulinyl-2'-deoxyadenosine (N-Bz)

DN-6601

164

5’-Levulinyl-2'-deoxycytidine (N-Bz)

DN-6602

164

5’-Levulinyl-2'-deoxyguanosine (N-iBu)

DN-6603164

5’-Levulinyl-2'-deoxythymidine

DN-6604164

3’-Levulinyl-2'-deoxyadenosine (N-Bz)

PM-6611160

3’-Levulinyl-2'-deoxycytidine (N-Bz)

PM-6612160

3’-Levulinyl-2'-deoxyguanosine (N-iBu)

PM-6613160

3’-Levulinyl-2'-deoxythymidine

PM-6614160

3’-O-Acetyl-2'-deoxyadenosine (N-Bz)

PM-6301164

3’-O-Acetyl-2'-deoxycytidine (N-Bz)

PM-6302

164

3’-O-Acetyl-2'-deoxyguanosine (N-iBu)

PM-6303164

3’-O-Acetyl-2'-deoxyuridine

PM-6305

164

3’-O-Acetyl-2'-thymidine

PM-6304

164

Aadenosine (N-isopentyl)

PM-6005

161

Adenosine (N-Bz)

PM-2101

161

Adenosine (N-PAC)

PM-6001

161

Cytidine (N-Ac)

PM-2106

161

Cytidine (N-Bz)

PM-2102

161

Cytidine (N-iBu)

PM-2105

161

Cytidine (N-PAC)

PM-6002

161

Guanosine (N-iBu)

PM-2103

161

Guanosine (N-PAC)

PM-6003

161

Guanosine (N-phenyl acetyl)

PM-6004

161

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Adenosine (N-Bz)

PM-1928162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Adenosine (N-iBu)

PM-1921

162

V: Iso ribo nucleoside
Iso-2'-deoxyguanosine
Base (N-protected) mononucleosides
I-Base (N-protected) deoxy mononucleosides
A: Standard and Labile deoxy nucleosides

B: 5’-Levulinyl deoxy Nucleoside

C: 3'-Levulinyl deoxy Nucleosides

D: 3'-O-Acetyl deoxy Nucleosides

II-Base (N-protected) ribo mononucleosides
A: Standard and Labile ribo nucleosides

B: 5',3'-Tetraisopropyl disiloxane ribo Nucleoside221

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#Page#

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Cytidine (N-Ac)

PM-1923162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Cytidine (N-iBu)

PM-1924162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)e-Adenosine (N-PAC)

PM-1922162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine (N-Ac)

PM-1926

162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine (N-iBu)

PM-1927162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-Guanosine (N-DMF)

PM-1925

162

RP-4128

162

C: 2', 3'-isopropylene ribo nucleosides
2',3'-Isopropylidene-guanosine (N-iBu)

222

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#Page#

7-Deaza-5'-O-DMTr-deoxyadenosine (N-Bz)

PM-6431169

7-Deaza-5'-O-DMTr-deoxyguanosine (N-iBu)

PM-6433

169

7-Deaza-5'-O-DMTr-deoxyinosine

PM-6434

169

5-Bromo-5'-O-DMTr-deoxyuridine

PM-2808171

5-Iodo-5'-O-DMTr-deoxycytidine (N-DBF)

PM-1979

171

5-Iodo-5'-O-DMTr-deoxyuridine

PM-2864

171

8-Bromo-5'-O-DMTr-deoxyadenosine (N-Bz)

PM-7210171

8-Bromo-5'-O-DMTr-deoxyadenosine (N-DBF)

PM-4791

171

8-Bromo-5'-O-DMTr-deoxyguanosine (N-iBu)

PM-7211171

5-Methyl-5'-O-DMTr-deoxycytidine (N-Bz)

PM-1967

168

5-Propynyl-5'-O-DMTr-deoxycytidine (N-Bz)

PM-1124

168

5-Propynyl-5'-O-DMTr-deoxyuridine

PM-1022

168

PM-1591

168

N -Methyl-5'-O-DMTr-deoxyadenosine

PM-1107

168

N-Cyanoethyl-5'-O-DMTr-deoxycytidine

PM-1489168

PM-1490168

PM-1643

168

PM-7307170

5'-O-DMTr-Adenosine (N-Bz)

PM-2109

167

5'-O-DMTr-Adenosine (N-Fmoc)

PM-4366

167

5'-O-DMTr-Adenosine (N-PAC)

PM-2203

167

5'-O-DMTr-Cytidine (N-Ac)

PM-2114167

5'-O-DMTr-Cytidine (N-Bz)

PM-2110167

5'-O-DMTr-Cytidine (N-Fmoc)

PM-4367

167

5'-O-DMTr-Cytidine (N-iBu)

PM-2113167

5'-O-DMTr-Cytidine (N-PAC)

PM-2204

167

5'-O-DMTr-Guanosine (N-Ac)

PM-4003

167

5'-O-DMTr-Guanosine (N-Fmoc)

PM-4368

167

5'-O-DMTr-Guanosine (N-iBu)

PM-2111167

5'-O-DMTr-Guanosine (N-isopropyl-PAC)

PM-2209

167

5'-O-DMTr-Guanosine (N-PAC)

PM-2205

167

5'-O-DMTr-Inosine

PM-2306

167

5'-O-DMTr-Thymidine

PM-2115167

5'-O-DMTr-Uridine

PM-2112167

B: 7-Deaza deoxy nucleosides

C: Halogenated deoxy nucleosides

D: 5-Alkylated deoxy nucleosides

E: N-Alkylated deoxy Modified Nucleosides
N3-Methyl-5'-O-DMTr-thymidine
63

N -Cyanoethyl-5'-O-DMTr-thymidine
G: Iso deoxy modified nucleoside
Iso-5'-O-DMTr-deoxyguanosine (N-DBF)
F: 3'-substituted deoxy modified nucleosides
3'-Azido-5'-O-DMTr-7-deaza-7-propargylamino (TFA)-2'-deoxyguanosine (N-PAC)
II-DMT Protected ribo Mononucleosides
A: ribo mononucleosides with Standard and Labile protection

223

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INDEX-1: Common Name
Nucleosides
Product Name

Catalog#Page#

2'-O-Methyl-5'-O-DMTr-adenosine (N-Bz)

PM-5731173

2'-O-Methyl-5'-O-DMTr-adenosine (N-PAC)

PM-3701173

2'-O-Methyl-5'-O-DMTr-cytidine (N-Ac)

PM-5735

173

2'-O-Methyl-5'-O-DMTr-cytidine (N-Bz)

PM-5732

173

2'-O-Methyl-5'-O-DMTr-cytidine (N-PAC)

PM-3702173

2'-O-Methyl-5'-O-DMTr-guanosine (N-iBu)

PM-5733

173

2'-O-Methyl-5'-O-DMTr-guanosine (N-PAC)

PM-3703173

2'-O-Methyl-5'-O-DMTr-uridine

PM-5734

173

2'-O-TBDMS-5'-O-DMTr-adenosine (N-diBz)

PM-5857

174

2'-O-TBDMS-5'-O-DMTr-adenosine (N-Bz)

PM-5851174

2'-O-TBDMS-5'-O-DMTr-adenosine (N-PAC)

PM-3501174

2'-O-TBDMS-5'-O-DMTr-cytidine (N-Ac)

PM-5856

174

2'-O-TBDMS-5'-O-DMTr-cytidine (N-Bz)

PM-5852

174

2'-O-TBDMS-5'-O-DMTr-cytidine (N-PAC)

PM-3502174

2'-O-TBDMS-5'-O-DMTr-guanosine (N-DMF)

PM-5859

174

2'-O-TBDMS-5'-O-DMTr-guanosine (N-iBu)

PM-5853

174

2'-O-TBDMS-5'-O-DMTr-guanosine (N-iPrPAC)

PM-3504174

2'-O-TBDMS-5'-O-DMTr-guanosine (N-PAC)

PM-3503174

2'-O-TBDMS-5'-O-DMTr-inosine

PM-5855

174

2'-O-TBDMS-5'-O-DMTr-uridine

PM-5854

174

3'-O-TBDMS-5'-O-DMTr-Adenosine (N-Bz)

PM-5861

175

3'-O-TBDMS-5'-O-DMTr-Cytidine (N-Bz)

PM-5862

175

3'-O-TBDMS-5'-O-DMTr-Guanosine (N-iBu)

PM-5863

175

3'-O-TBDMS-5'-O-DMTr-Uridine

PM-5864

175

3'-O-TBDMS-5'-O-DMTr-Cytidine (N-Ac)

PM-5866

175

2'-O-Methyl-5-methyl-5'-O-DMTr-cytidine (N-Bz)

PM-3705

173

2'-O-Methyl-5-methyl-5'-O-DMTr-uridine

PM-3706

173

2'-O-Methyl-5-propynyl-5'-O-DMTr-cytidine (N-Bz)

PM-1129173

2'-O-Methyl-5-propynyl-5'-O-DMTr-uridine

PM-1027173

5-Methyl-5'-O-DMTr-cytidine (N-Bz)

PM-2647

172

5-Propynyl-5'-O-DMTr-cytidine (N-Bz)

PM-1126

172

5-Propynyl-5'-O-DMTr-uridine

PM-1024

172

PM-2476

172

PM-1834

172

B: 2'-O-Methyl ribo nucleosides

C: 2'-O-TBDMS ribo modified nucleosides

D: 3'-O-TBDMS ribo modified nucleosides

E: 2’-O-Methyl-5-Alkylated ribo nucleosides

F: 5-Alkylated ribo modified nucleosides

G: Modified purine ribo nucleosides
5'-O-DMTr-Purine-riboside (N6-DMF) (N2-iBu)
H: Halogenated ribo nucleosides
8-Bromo-5'-O-DMTr-adenosine (N-DBF)

224

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INDEX-1: Common Name
Reagents for Nucleic acid Chemistry
Product Name

Catalog#Page#

1H-1,2,4-Triazole, (1,2,4-Triazole)

RN-1412176

1H-Imidazole-4,5-dicarbonitrile, (Dicyanoimidazole (DCI))

RN-1571

176

5-Benzyl-thio-1-H-tetrazole (BMT)

RN-1415176

5-Ethyl-thio-1-H-tetrazole (ETT)RN-6397

176

Diisopropyl-ammonium-1H-tetrazolide

RN-1413176

Dimethoxytrityl-Chloride; DMTr-Chloride

RN-1401

177

Mesitylene Sulphonyl-3-Nitro-1,2,4-Triazole (MSNT))RN-1403

176

Monoimethoxytrityl-Chloride; MMTr-Chloride

RN-1574

177

Trimethoxytrityl-Chloride; TMTr-Chloride

RN-1491

177

Phenylacetyl-Disulfide (PADS)

RN-1496

178

Silanized Bottle (for Beaucage Reagent)

BL-1536

178

DDTT ((Dimethylamino-methylidene)amino)-3H-1,2,4dithiazoline-3-thione / Sulfurizing Reagent *"RN-1588178

3H-1,2-Benzodithiol-3-one-1,1-dioxide/ Sulfurizing
Reagent / Sulfurizing Reagent (Beaucage Reagent)"

RN-1535

178

Dichloromethoxy-phosphite

RN-1407179

2-Cyanoethyl-N,N,N,N-teraisopropylphosphane

RN-1545179

Bis (diisopropylamino)-chlorophosphine

RN-8882

179

Cyanoethyl-dichlorophosphite

RN-8883

179

Diethoxy-N,N-diisopropyl-phosphoramidite

RN-1410

179

Diethyl-phosphorochloride

RN-1408180

Ethylene-glycol-morpholino phosphoramidite

RN-1516

179

Methoxy-N,N,N,N-tetraisopropylphosphane

RN-8881

179

N,N-Diisopropylamino-Cyanoethyl
phosphonamidic-chloride"

RN-1505

179

N,N-Diisopropylamino-methyl-phosphonamidic-chloride

RN-1510179

N,N-Diisopropyl-methoxy-phosphonamidic-Cl

RN-1409

180

O-Chlorophenyl-phosphorodichloridate

RN-1421180

P-Ethoxy-Chloro-Reagent

RN-41371804-Isopropyl-Phenoxy-Acetyl-Chloride

RN-1705

180

Bis-Silyating Reagent

RN-1521180

1,3,5-Tri –O-acetyl-2-deoxy-β-L-ribose

RN-1065

181

1,3,5-Tri–O-acetyl-2-deoxy-β-D-ribose

RN-1064181

1-Alpha-Chloro-3,5-ditoluoyl-2-deoxy-β-D-ribose

RN-4130

181

1-O-Methyl-2,3,5-tri-O-benzoyl-β-D-ribose

RN-1031181

2,3,5-O-Tribenzoyl-β-D-Ribofuranosyl-1-Acetate

RN-4131181

2-Deoxy-β-D-ribose

RN-1061181

2-Deoxy-β-L-ribose

RP-1062181

6-Chloro-7-deaza-Guanine

BS-1011181

6-Chloro-7-deaza-Purine

RP-1021181

6-Chloro-Guanine

RN-1051

181

6-Chloro-Purine

RN-1030

181

Reagents for nucleic acid chemistry
A: Activation Reagents

B: Beaucage Reagents & Sufurizing reagents

C: Phosphorylating Reagents

D: Nucleoside Synthesis Reagents

E: Sugars, Purines & Pyrimidines

225

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INDEX-1: Common Name
NHS ester/Monophosphate/Diphosphate
Product Name

Catalog#

Page#

5-Fluorescein-Dipivalate-NHS Ester(5-FAM Dipivalate NHS Ester)"

RN-9652

182

5-Fluorescein-NHS Ester(5-FAM NHS Este"

RN-9662

182

6-Fluorescein-Dipivalate-NHS Ester(6-FAM Dipivalate NHS Ester)"

RN-9651

182

6-Fluorescein-NHS Ester(6-FAM NHS Ester)"

RN-9661182

Biotin-Amido-Caproate-N-Hydroxy

RN-1449

183

Biotin-Ester (N-Hydroxysuccinimide)

RN-1500

183

Biotin-X-Y-SSE (Biotinamidohexanoyl-amidobutanoyl Succinimidyl ester)RN-1508

183

NHS esters
A: Fluorescein

B: Biotin

Monophosphates
A: Deoxy N-Alkylated monophosphates
NMP-8431

186

3

NMP-8432

186

6

NMP-8433

186

Etheno-deoxycytidine-5’-monophosphate

NMP-8434

186

Etheno-ribocytidine-5’-monophosphate

NMP-8317

185

NMP-8435

186

N1-Methyl-deoxyadenosine-5’-monophosphate
N -Methyl-deoxycytidine-5’-monophosphate
N -Methyl-deoxyadenosine-5’-monophosphate
B: Etheno deoxy & ribo monophosphates

C: 7-Deaza deoxymonophosphate
7-Deaza-deoxyadenosine-5’-monophosphate
D: 2’-O-Methyl-ribo monophosphates2’-O-Methyl-adenosine (N6-Benzyl)-5’-monophosphate

NMP-8313

184

2’-O-Methyl-cytidine-5’-monophosphate

NMP-8311

184

2’-O-Methyl-guanosine-5’-monophosphate

NMP-8312

184

β-L-Adenosine-5’-monophosphate sodium salt

NMP-8314

184

β-L-Uridine-5’-monophosphate sodium salt

NMP-8315

184

3'-Amino-guanosine-5’-monophosphate

NMP-8316

185

3'-Methyl-guanosine-5’-monophosphate

NMP-8319

185

NMP-8310

185

NMP-8318

185

2'-O-Methyl-adenosine-3’,5’-diphosphate disodium salt

NDP-7311

187

2'-O-Methyl-cytidine-3’,5’-diphosphate disodium salt

NDP-7312

187

2'-O-Methyl-guanosine-3’,5’-diphosphate disodium salt

NDP-7313

187

2'-O-Methyl-uridine-3’,5’-diphosphate disodium salt

NDP-7314

187

Uridine-5’-diphosphate

NDP-7316

187

Uridine-5’-diphosphate disodium salt

NDP-7315

187

E: β-L-ribo monophosphates

F: 3'-Substituted-ribo monophosphates

G: ribo monophosphate
Thymidine-5’-monophosphate
H: Iso ribo monophosphate
Iso-guanosine (N-iBu)-5’-monophosphate

Diphosphates
A: 2'-O-Methyl ribo 3’,5’-diphosphates

B: Ribo U 5'-diphoosphates

226

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INDEX-1: Common Name
Triphosphate
Product Name

Catalog#

Page#

Etheno-deoxyadenosine-5’-triphosphate disodium salt

NTP-4344

189

Etheno-deoxycytidine-5’-triphosphate disodium salt

NTP-4346

189

7-Deaza-deoxyadenosine-5’-triphosphate disodium salt

NTP-4384

189

7-Deaza-deoxyguanosine-5’-triphosphate disodium salt

NTP-4386

189

NTP-4396

189

7-Deaza-7-propargylamine-2',3'-dideoxyadenosine-5’-triphosphate

NTP-6311

191

7-Deaza-7-propargylamine-2',3'-dideoxyadenosine-5’-triphosphate disodium salt

NTP-6312

191

7-Deaza-7-propargylamine-2',3'-dideoxyguanosine-5’-triphosphate disodium salt

NTP-6313

191

5-Propargylamine-2',3'-dideoxycytidine-5’-triphosphate

NTP-5318

191

5-Propargylamine-2',3'-dideoxycytidine-5’-triphosphate disodium salt

NTP-5316

191

5-Propargylamine-2',3'-dideoxyuridine-5’-triphosphate disodium salt

NTP-5317

191

NTP-6316

191

2'-O-Methyl-adenosine-5’-triphosphate disodium salt

NTP-3386

188

2'-O-Methyl-cytidine-5’-triphosphate disodium salt

NTP-3387

188

2'-O-Methyl-guanosine-5’-triphosphate disodium salt

NTP-3388

188

2'-O-Methyl-uridine-5’-triphosphate disodium salt

NTP-3389

188

Ara-adenosine-5’-triphosphate disodium salt

NTP-5411

190

Ara-cytidine-5’-triphosphate disodium salt

NTP-5412

190

Ara-guanosine-5’-triphosphate disodium salt

NTP-5413

190

Ara-uridine-5’-triphosphate disodium salt

NTP-5414

190

Ara-(2'-O-Methyl)-adenosine-5’-triphosphate disodium salt

NTP-5311

190

Ara-(2'-O-Methyl)-cytidine-5’-triphosphate disodium salt

NTP-5312

190

Ara-(2'-O-Methyl)-guanosine-5’-triphosphate disodium salt

NTP-5313

190

Ara-(2'-O-Methyl)-uridine-5’-triphosphate disodium salt

NTP-5314

190

NTP-4348

188

Triphosphates
A: Etheno deoxy 5’-triphosphates

B: 7-Deaza-deoxy 5’-triphosphates

C: Iso deoxy Triphosphate
Iso-deoxyguanosine-5’-triphosphate disodium salt
D: 7-Deaza-7-Propargylamine, dideoxy Triphosphates

E: 5-Propargyl amine-2',3'-Dideoxy Triphosphates

F: 2',3'-Dideoxy G Triphosphate
2',3'-Dideoxyguanosine-5’-triphosphate
G: 2'-O-Methyl-ribo 5’-triphosphates

H: Ara-ribo Triphosphates

I: Ara-2'-O-Methyl-ribo Triphosphates

J: Iso ribo triphosphate
Iso-Guanosine-5’-triphosphate disodium salt

227

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INDEX-2: IUPAC Name, A
Product Name

Catalog#

Page#

1-O-Acetyl-2,3,5-O-tribenzoyl-β-D-ribose

RN-4131181

2-Amino-2'-deoxy-β-L-adenosine

DN-8331

146

2-Amino-2'-O-methyl-β-L-adenosine

RP-3902155

2'-O-Acetyl-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-ara-uridine

ANP-1715

32

2'-O-Acetyl-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-acetyl-ara-cytidine

ANP-1714

32

2'-O-Acetyl-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-benzoyl-ara-adenosine

ANP-1711

32

2'-O-Acetyl-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-benzoyl-ara-cytidine

ANP-1712

32

2'-O-Acetyl-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-isobutyryl-ara-guanosine

ANP-1713

32

2'-O-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-ara-uridine

N-7422-05/10/20

32

2'-O-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-benzoyl-ara-adenosine

N-7366-05/10/20

32

2'-O-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-benzoyl-ara-cytidine

N-7367-05/10/20

32

2'-O-Acetyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-isobutyryl-ara-guanosine

N-7421-05/10/20

32

3’-Amino(trityl)-3’deoxy-5’-O-succinyl(lcaa-CPG)-thymidine

N-8024-05/10

122

3'-Amino-3’-deoxy-guanosine-5’-monophosphate

NMP-8316

185

3'-Azido-2‘,3’-dideoxy-5'-O-(4,4'-dimethoxytrityl)-7-deaza-7-(trifluoroacetamidopropargyl)-N-(phenoxyacetyl)guanosine

PM-7307170

3'-Azido-3’-deoxythymidine

DN-1774

147

3'-O-Allyl-adenosine

RP-3111157

3'-O-Allyl-cytidine

RP-3112157

3'-O-Allyl-guanosine

RP-3113157

3'-O-Allyl-uridine

RP-3114

157

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings) , ABI Oligonucleotide Synthesizer

RN-1447

20

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), ABI 3900 Oligonucleotide Synthesizer

RN-1447

21

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), Expedite Oligonucleotide Synthesizer

RN-1447

23

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), MerMade Oligonucleotide Synthesizer

RN-1447

24

Acetonitrile Anhydrous (Phosphoramidite Diluent & Washings), PolyPlex Oligonucleotide Synthesizer

RN-1447

25

Acetonitrile Wash Grade, ABI 3900 Oligonucleotide Synthesizer

RN-1448

21

Acetonitrile Wash Grade, ABI Oligonucleotide Synthesizer

RN-1448

20

Acetonitrile Wash Grade, Expedite Oligonucleotide Synthesizer

RN-1448

23

Acetonitrile Wash Grade, MerMade Oligonucleotide Synthesizer

RN-1448

24

Acetonitrile Wash Grade,PolyPlex Oligonucleotide Synthesizer

RN-1448

25

Acetonitrile/Pyridine (50:50), Anhydrous (Diluent for Monomers)

RN-4523-P

19

Acetonitrile/Pyridine (95:5), Anhydrous (Diluent for Activator)

RN-1356-P2

19

Acetonitrile/Pyridine (wash solvent)

RN-7684-AP

19

Activation Reagent ((0.25M 5-Ethylthio Tetrazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1466

20

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), ABI 3900 Oligonucleotide Synthesizer

RN-1467

21

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1467

20

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1467

23

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1467

24

Activation Reagent (0.25M 4,5-Dicyanoimidazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1467

25

Activation Reagent (0.25M 5-Ethylthio-1H-Tetrazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1466

23

Activation Reagent (0.25M 5-Ethylthio-1H-Tetrazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1466

21

Activation Reagent (0.25M 5-Ethylthio-1H-Tetrazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1551

24

Activation Reagent (0.25M 5-Ethylthio-1H-Tetrazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1466

25

Activation Reagent (0.45M 5-Ethylthio-1H-Tetrazole/Acetonitrile), ABI 3900 Oligonucleotide Synthesizer

RN-1551

21

A

228

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INDEX-2: IUPAC Name, A
Product Name

Catalog#

Page#

Activation Reagent (0.45M 5-Ethylthio-1H-Tetrazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1551

20

Activation Reagent (0.45M 5-Ethylthio-1H-Tetrazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1551

23

Activation Reagent (0.45M 5-Ethylthio-1H-Tetrazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1551

24

Activation Reagent (0.45M 5-Ethylthio-1H-Tetrazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1551

25

Activation Reagent (BMT Solution) (0.3M Benzylthio-1H-Tetrazole/Acetonitrile)

RN-1452

21

Activation Reagent (BMT Solution) (0.3M Benzylthio-1H-Tetrazole/Acetonitrile), ABI Oligonucleotide Synthesizer

RN-1452

20

Activation Reagent (BMT Solution) (0.3M Benzylthio-1H-Tetrazole/Acetonitrile), Expedite Oligonucleotide Synthesizer

RN-1452

23

Activation Reagent (BMT Solution) (0.3M Benzylthio-1H-Tetrazole/Acetonitrile), MerMade Oligonucleotide Synthesizer

RN-1452

24

Activation Reagent (BMT Solution) (0.3M Benzylthio-1H-Tetrazole/Acetonitrile), PolyPlex Oligonucleotide Synthesizer

RN-1452

25

Activator (Benzyl thio-1H-tetrazole; 0.2M in acetonitrile), Akta Oligonucleotide Synthesizer

RN-2232

22

Activator for monomers and Capping Reagent (Adamantane catbonyl chloride)

RN-6664

19

Adenosine

RP-1183

149

AMA Reagent, ABI 3900 Oligonucleotide Synthesizer

RN-145021

AMA Reagent, ABI Oligonucleotide Synthesizers

RN-145020

AMA Reagent, Expedite Oligonucleotide Synthesizer

RN-145023

AMA Reagent, MerMade Oligonucleotide Synthesizer

RN-145024

AMA Reagent, PolyPlex Oligonucleotide Synthesizer

RN-1450

25

Amino Icaa CPG Support 1000Å

N-5100-10

18

Amino Icaa CPG Support 500ÅN-5100-05

18

Amino Modifier-C6-2'-O-Methyl-cytidine (N-DMF)-5'-O-DMT-3'-CEP; Amino Modifier

ANP-2583

94

Amino Modifier-C6-2'-O-Methyl-ruridine-5'-O-DMT-3'-CEP; Amino Modifier

ANP-2581

94

Amino-(Spacer-7) Icaa CPG

N-1577-05/10

119

Amino-modifier-C6-dT CEP

CLP-1501

122

Amino-modifier-C6-dT CPG; Amino-dT (C6) lcaa CPG

N-6054-05/10

122

Amino-modifier-C6-Phthalamido CEP; Phthalamido C6 Amino Linker CEP

CLP-1328

123

Amino-modifier-Spacer-13-dC CEP; Deoxycytidine-N4-Amino Linker CEP

CLP-1329

120

Amino-modifier-Spacer-13-dC CPG; Deoxycytidine-N4-Amino Linker lcaa CPG

N-6052-05/10

119

Ammonia Free Oligo Deprotection Solution

RN-1435

61

Ammonia Free Oligo Deprotection Solution

RN-1435

104

Anhydrous Ammonia in Ethanol Solution (20% ammonia by wt in absolute ethanol)

CSS-3268

91

Ara-5-methyl-cytidine

RP-1835

149

Ara-7-deaza-guanosine

RP-4311154

Ara-adenosine-5’-triphosphate

NTP-5411

190

Ara-cytidine-5’-triphosphate

NTP-5412

190

Ara-guanosine-5’-triphosphate

NTP-5413

190

Ara-uridine

RP-2325

149

Ara-uridine-5’-triphosphate

NTP-5414

190

229

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INDEX, e-gu

INDEX-2: IUPAC Name, B
Product Name

Catalog#Page#

2'-O-Butyne-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-benzoyl-adenosine

ANP-7621

108

2'-O-Butyne-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-benzoyl-cytidine

ANP-7622

108

2'-O-Butyne-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-isobutyryl-guanosine

ANP-7623

108

2'-O-Butyne-3'-O-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-uridine

ANP-7625

108

2'-O-Butyne-5'-O-(4,4'-dimethoxytrityl)-3-O-succinyl(lcaa-CPG)-N-benzoyl-adenosine

N-9611-05/10

1082'-O-Butyne-5'-O-(4,4'-dimethoxytrityl)-3-O-succinyl(lcaa-CPG)-N-benzoyl-cytidine

N-9612-05/10

1082'-O-Butyne-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-isobutyryl-guanosine

N-9613-05/05,

1082'-O-Butyne-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-uridine

N-9614-05/10

108

3H-1,2-Benzodithiole-3-one-1,1-dioxide/ Sulfurizing Reagent / Sulfurizing Reagent (Beaucage Reagent)

RN-1535

178

4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-((2-cyanoethoxy)(diisopropylamino)phosphinooxy)butyl 4-oxopentanoate

CLP-7169129

4-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-O-succinyl(lcaa-CPG)butyl 4-oxopentanoate

N-7170-05/10

129

5-Benzyl-thio-1-H-tetrazole (BMT)

RN-1415176

5-Bromo-2’-deoxy-5'-O-(4,4'-dimethoxytrityl)-uridine

PM-2808171

5-Bromo-2'-deoxy-cytidine

DN-6496

143

5-Bromo-2'-deoxy-uridine

DN-1136

143

5-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-Nbenzyl-cytidine

ANP-5648

84

5-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)uridine

ANP-7411

84

5-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-benzoyl-cytidine

ANP-6141

36

5-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-uridine

ANP-6415

36

5-Bromo-5'-O-(4,4'-dimethoxytrityl)- -3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

N-9818-05/10

85

5-Bromo-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-cytidine

N-9844-05/10

85

5-Bromo-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-deoxy-N-benzoyl-cytidine

N-7362-05/10

37

5-Bromo-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-deoxy-uridine

N-1378-05/10

37

5-Bromo-cytidine

RP-1215151

5-Bromo-uridine

RP-1192

151

8-Bromo-2'-deoxy-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-benzoyl-adenosine

ANP-4703

37

8-Bromo-2'-deoxy-5'-O-(4,4'-dimethoxytrityl) -N-benzoyl-adenosine

PM-7210171

8-Bromo-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-N-benzoyl-adenosine

N-4705-05/10

37

8-Bromo-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-N-isobutyryl-guanosine

N-9921-05/10

37

8-Bromo-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-3-O-succinyl(lcaa-CPG)- N-(N,N-dibutylformamidine)-adenosine

N-4704-05/10

37

8-Bromo-2'-deoxy-adenosine

DN-1182

143

8-Bromo-2'-deoxy-guanosine

DN-1203

143

8-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)- 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N-isobutyryl-guanosine

ANP-6152

37

8-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N-(N,N-dibutylformamidine)adenosine

ANP-4702

37

8-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N(N,N-dibutylformamidine)-adenosine

ANP-7111

85

8-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N(N,N-dimethylformamidine)-adenosine

ANP-711285

8-Bromo-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N(N,N-dimethylformamidine)-guanosine

ANP-7113

85

8-Bromo-5'-O-(4,4'-dimethoxytrityl)- 3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-(N,Ndibutylformamidine)-adenosine

N-9812-05/10

85

8-Bromo-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-(isobutyryl)-guanosine

PM-7211171

8-Bromo-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-(N,N-dibutylformamidine)-adenosine

PM-4791

171

8-Bromo-5'-O-(4,4'-dimethoxytrityl)-N-(N,N-dibutylformamidine)-adenosine

PM-1834

171

230

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INDEX, cy-do

INDEX-2: IUPAC Name, B-C

Product Name

Catalog#

Page#

8-Bromo-adenosine

RP-1214151

8-Bromo-guanosine

RP-1216151

Barrel-4 ml for DNA purification

CSS-3940-S

52

Barrel-4 ml for DNA purification

CSS-3940-M

52

Barrel-4 ml for DNA purification

CSS-3940-L

52

Barrel-8 ml for DNA purification

CSS-3960-S

52

Barrel-8 ml for DNA purification

CSS-3960-M

52

Barrel-8 ml for DNA purification

CSS-3960-L

52

Biotin (BB)-TM (2-cyanoethyl diisopropylphosphoramidite)

CLP-1517

128

Biotin (BB)-TM CPG; (D-(+) Biotin lcaa CPG)

N-9162-05

128

Biotin (BB)TM-(2-cyanoethyl diisopropylphosphoramidite)

CLP-1518

128

Biotin-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-thymidine

CLP-1502

128

Biotin-amido-hexanoic acid NHS ester

RN-1449

128

Biotin-Ester (N-Hydroxysuccinimide) (NHS-Ester)RN-1500

183

Biotin-TEG lcaa CPG

N-1506-05

128

Biotin-X-Y-SSE (Biotinamidohexanoyl-amidobutanoyl Succinimidyl ester) (NHS-Ester)RN-1508

183

Bis(diisopropylamino)-chlorophosphine

RN-8882

179

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)N-isobutyryl-guanosine

ANP-5683

72

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-inosine

ANP-5687

72

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-acetylcytidine

ANP-5686

72

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyladenosine

ANP-5681

72

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-benzoylcytidine

ANP-5682

72

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-uridine

ANP-5684

72

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-inosine

ANP-2905

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-N-(isobutyryl)-guanosine

ANP-2903

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-N-acetyl-cytidine

ANP-2906

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-N-benzoyl-adenosine

ANP-2901

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-N-benzoyl-cytidine

ANP-2902

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-thymidine

ANP-2907

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-methyl-uridine

ANP-2904

102

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-propargyl-N-acetyl-cytidine

ANP-9759

113

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-propargyl-N-benzoyl-adenosine

ANP-9751

113

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-propargyl-N-benzoyl-cytidine

ANP-9752

113

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-propargyl-N-isobutyryl-guanosine

ANP-9753

113

2'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-3'-O-propargyl-uridine

ANP-9754

113

2-Cyanoethyl 12-((4-methoxyphenyl)diphenylmethylamino)dodecyl diisopropylphosphoramidite

CLP-1585

121

2-Cyanoethyl 12-(2,2,2-trifluoroacetamido)dodecyl diisopropylphosphoramidite

CLP-1575

121

C

231

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX, l-pr

INDEX-2: IUPAC Name, B
Product Name

Catalog#

Page#

2-Cyanoethyl 4-(2,2,2-trifluoroacetamido)butyl diisopropylphosphoramidite

CLP-1453

119

2-Cyanoethyl 5-(2,2,2-trifluoroacetamido)pentyl diisopropylphosphoramidite

CLP-1357

119

2-Cyanoethyl 6-((4-methoxyphenyl)diphenylmethylamino)hexyl diisopropylphosphoramidite

CLP-1563

119

2-Cyanoethyl 6-(2,2,2-trifluoroacetamido)hexyl diisopropylphosphoramidite

CLP-1553

119

2-Cyanoethyl-N,N,N,N-teraisopropyl phosphane

RN-1545179

3'-(2-Cyanoethyl diisopropylphosphoramidite)- 2’,5-dideoxy 5-iodo-thymidine

ANP-4613

36

3'-(2-Cyanoethyl diisopropylphosphoramidite)- -2'-deoxy -5'-O-(4,4'-dimethoxytrityl)-N-benzoyl -β-L-cytidine

ANP-8032

44

3'-(2-Cyanoethyl diisopropylphosphoramidite)- 2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2-thio-uridine

ANP-921427

3'-(2-Cyanoethyl diisopropylphosphoramidite)- 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)- β-L-uridine

ANP-8036

44

3'-(2-Cyanoethyl diisopropylphosphoramidite)- 5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5-methyl-N-bezoyl-cytidine

ANP-6556

96

3'-(2-Cyanoethyl diisopropylphosphoramidite)- 5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-ara-inosine

ANP-9851

114

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-((4,4'-dimethoxytrityl)-N-acetyl-α-D-cytidine

ANP-4676

29

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-((4,4'-dimethoxytrityl)-N-benzoyl-α-D-adenosine

ANP-1651

29

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-((4,4'-dimethoxytrityl)-N-bezoyl-α-D-cytidine

ANP-1652

29

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-((4,4'-dimethoxytrityl)-N-isobutyryl-α-D-guanosine

ANP-1653

29

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-5-methyl-uridine

ANP-9233

80

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-inosine

ANP-9234

80

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-(isobutyryl)-guanosine

ANP-9153

78

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-(isopropyl phenoxyacetyl)guanosine

ANP-913479

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-(N,N’-dimethylformamidine)adenosine

ANP-9157

78

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-(N,N’-dimethylformamidine)guanosine

ANP-9159

78

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-acetyl-5-methyl-cytidine

ANP-923180

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-acetyl-cytidine

ANP-9152

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-benzoyl-5-methyl-cytidine

ANP-9232

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-benzoyl-adenosine

ANP-9151

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-phenoxyacetyl-adenosine

ANP-9131

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-uridine

ANP-9154

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-uridine

ANP-923580

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-5-fluoro-uridine

ANP-6151

36

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-5-iodo-uridine

ANP-4611

36

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-7- trifluoroacetamidopropargyl-N-(N,N’-dimethylformamidine)-guanosine

ANP-1354

34

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-7-iodo-N-(N,N’dimethylformamidine)-adenosine

ANP-4586

34

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-7-iodo-N-(N,N’dimethylformamidine)-guanosine

ANP-4589

34

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-7-trifluoroacetamidopropargyl-N(N,N’-dimethylformamidine)-adenosine

ANP-1339

34

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-inosine

ANP-1146

33

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-N- isobutyryl-guanosine

ANP-4857

33

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-N-acetyl-guanosine

ANP-4858

33

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-N-benzoyl-adenosine

ANP-4815

33

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-8-methyl-N-isobutyryl-guanosine

ANP-9274

41

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-8-oxo-N-(N,N’-dimethylformamidine)guanosine

ANP-9311-2

46

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-8-oxo-N-benzoyl-adenosine

ANP-9301

46

80
79

232

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Email: info@chemgenes.com

INDEX, gu-is

INDEX-2: IUPAC Name, B

Product Name

Catalog#Page#3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-cytidine

ANP-7772

7

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-N-(N,N’-dibutylformamidine)-iso-cytidine

ANP-4269

43

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-N-(N,N’-dibutylformamidine)-iso-guanosine

ANP-4268

43

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-N3-methyl-N-benzoyl-cytidine

ANP-3851

38

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isobutyryl-cytidine

ANP-5559

3

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-N-methyl-adenosine

ANP-3855

39

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-N-phenoxyacetyl-cytidine

ANP-6662

5

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4’-dimethoxytrityl)-O6-trimethylsilylethyl-2-fluoro-inosine

ANP-7702

40

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-6-chloropurine-riboside

ANP-7706

42

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-adenosine

ANP-7771

7

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N-(tert-butyl phenoxy acetyl)-adenosine

ANP-5569

5

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N-acetyl-β-L-cytidine

ANP-8035

45

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N-isobutyryl-β-L-guanosine

ANP-8033

45

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N-phenoxy acetyl-adenosine

ANP-6661

5

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4-methoxytrityl)-N- benzoyl-cytidine

ANP-5558

3

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-(4-methoxytrityl)-N-phenoxy acetyl-adenosine

ANP-5116

53'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-levulinyl-N-benzoyl-adenosine

ANP-5001

12

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-levulinyl-N-benzoyl-cytosine

ANP-5002

12

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-levulinyl-N-isobutyryl-guanosine

ANP-5003

12

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-levulinyl-thymidine

ANP-5004

12

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-methyl-N-benzoyl-adenosine

ANP-5511

49

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-methyl-N-benzoyl-cytidine

ANP-551249

3'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-5'-O-methyl-N-isobutyryl-guanosine

ANP-5513

49

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-(4'-monomethoxytrityl)amino-thymidine

ANP-9402

31

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-(trifluoroacetamido)-2'-(tert-butyl(methoxy)dimethylsilane)-N-acetyl-cytidine

ANP-9405

82

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)- 2'-(tert-butyl(methoxy)dimethylsilane)-ribothymidine

ANP-7511

74

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)- 2'-deoxy-6-cyanoethylthio-N-acetyl-guanosine

ANP-7628

35

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane -inosine

ANP-5680

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)- 8-oxo7-allyl-N-isobutyryl-guanosine

ANP-9422

85

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-5-fluorouridine

ANP-6154

84

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-5-iodoN-benzoyl-cytidine

ANP-721284

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-5-iodouridine

ANP-7412

84

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-5-methyl-Nbenzoyl-cytidine

ANP-5675

74

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza-Nacetyl-guanosine

ANP-7302

83

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza-Nbenzoyl-adenosine (Tubercidin CEP)

ANP-7101

83

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-8-methyl-Nisobutyryl-guanosine

ANP-6274

73

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-8-oxo-N(N,N’-dimethylformamidine)-guanosine

ANP-942085

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-(N,N’dibutylformamidine-iso-guanosine

ANP-5988

86

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N,N’-dimethyl-adenosine

ANP-862676

233

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, C
Product Name

Catalog#Page#3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N,N’-dimethyl-adenosine

ANP-8626

75

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N3-benzothioethyl-uridine

ANP-7441

73

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-isopentenyl-adenosine

ANP-8615

75

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-methylribo-thymidine

ANP-7461

73

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-methyluridine

ANP-7451

73

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-Phenylacetyl-guanosine

ANP-5679

59

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-purineriboside Nebularine CEP

ANP-8616

80

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-pyridine2-one-riboside; Zebularine CEP

ANP-8611

76

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

ANP-5674

57

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-2'-deoxy-4-cyanoethylthio-uridine

ANP-7624

27

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-deoxy-4-triazoyl-uridine

ANP-9211

43

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-deoxy-5-Iodo-N-(N,N’-dibutylformamidine)cytidine

ANP-4591

36

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-deoxy-O6-diphenylcarbonyl-N-isobutyryl-guanosine

ANP-9276

40

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-(tert-butyl(methoxy)dimethylsilane)-4-cyanoethylthio-uridine

ANP-810176

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-(tert-butyl(methoxy)dimethylsilane)-4-triazoyluridine

ANP-916776

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-(triisopropyl-siloxymethyl)-N-acetyl-adenosine

ANP-320169

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-(triisopropyl-siloxymethyl)-N-acetyl-cytidine

ANP-320269

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-(triisopropyl-siloxymethyl)-N-acetyl-guanosine

ANP-320369

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-(triisopropyl-siloxymethyl)-uridine

ANP-320469

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-hexynyl-1,1-dihydro-ribose

ANP-9781

115

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-hexynyl-inosine

ANP-9852

115

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl N-(isobutyryl)-guanosine

ANP-5753

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl N-(phenoxyacetyl)-guanosine

ANP-6753

95

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-Methyl- N-phenoxyacetyl-adenosine

ANP-6751

95

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-2,6-bis-(phenoxyacetyl)-amino-purineriboside

ANP-8519

96

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-4-triazolyl-uridine

ANP-5604

97

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-bromo-uridine

ANP-5760

98

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-iodo-uridine

ANP-5759

98

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-methyl- N-(N,N’dimethylformamidine)cytidine

ANP-6554

96

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-methyl-N-acetyl-cytidine

ANP-6555

96

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-propynyl-N-benzoyl-cytidine

ANP-1874

97

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-propynyl-uridine

ANP-1347

97

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-7-iodo-N-benzoyl-adenosine

ANP-917199

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-7-iodo-N-isobutyryl-guanosine

ANP-9173

99

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-7-trifluoroacetamidopropargyl-N-benzoyl-adenosine

ANP-9176

99

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-7-trifluoroacetamidopropargyl-N-isobutyryl-guanosine

ANP-9178

99234

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Email: info@chemgenes.com

INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-7-trifluoroacetamidopropargyl-N-isobutyryl-guanosine

ANP-9178

99

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-N-benzoyl-adenosine

ANP-5951

99

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-7-deaza-N-isobutyryl-guanosine

ANP-5953

99

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-inosine

ANP-5758

96

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-(isopropylphenoxyacetyl)-guanosine

ANP-5761

95

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-(N,N’-dimethylformamidine)guanosine

ANP-6759

95

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-acetyl-cytidine

ANP-6756

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-benzoyl-adenosine

ANP-5751

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-benzoyl-cytidine

ANP-5752

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-phenoxyacetyl-cytidine

ANP-6752

95

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-uridine

ANP-5754

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-pivaloyloxymethyl-N-acetyl-cytidine

ANP-3217

63

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-pivaloyloxymethyl-N-isopropylphenoxyacetyl-guanosine

ANP-3218

63

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-pivaloyloxymethyl-N-phenoxyacetyladenosine

ANP-3216

63

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-pivaloyloxymethyl-uridine

ANP-3219

63

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-1,1-dihydro-ribose(2'-O-Propargyl-abasic-cyanoethyl phosphoramidite)

ANP-9782

114

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-inosine

ANP-6191

112

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-N-acetyl-cytidine

ANP-7756

112

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-N-benzoyl-adenosine

ANP-7751

112

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-N-benzoyl-cytidine

ANP-7752

112

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-N-isobutyryl-guanosine

ANP-7753

112

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-propargyl-uridine

ANP-7754

112

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-trifluoroacetamidopropyl-N-bezoyl-cytidine

ANP-711631

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-O-trifluoroacetamidopropyl-uridine

ANP-711531

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-4-cyanoethylthio-thymidine

ANP-6414

27

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-4-triazoyl-thymidine

ANP-921243

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-N-methyl-thymidine

ANP-6153

38

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-thymidine

ANP-5554

5

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-acetylβ-L-cytidine

ANP-4846

88

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoylβ-L-adenosine

ANP-4841

88

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoylβ-L-cytidine

ANP-4842

88

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzyladenosine

ANP-8614

76

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-Nisobutyryl-β-L-guanosine

ANP-4843

88

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-β-Lribothymidine

ANP-4844

88

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-β-L-uridine

ANP-4845

88

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy- N-(N,N’-dimethylformamidine)guanosine

ANP-6769

5

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-acetyl-cytidine.

ANP-5560

3

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-benzoyl-5-methyl-α-D-cytidine

ANP-1756

29

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-benzoyl-cytidine

ANP-5552

3

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-ara-uridine(mistake catalogue)

ANP-1721

111

235

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, C
Product Name

Catalog#Page#3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-N-acetyl-ara-cytidine

ANP-1718

111

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-N-benzoyl-ara-adenosine

ANP-1716

111

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-N-benzoyl-ara-cytidine

ANP-1717

111

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-N-isobutyryl-ara-guanosine

ANP-1719

111

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-cyanoethyl-thymidine

ANP-3857

38

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-α-D-thymidine

ANP-1654

29

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-β-L-thymidine

ANP-8034

44

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4-Methoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetylguanosine

ANP-6677

59

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4-methoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

ANP-5688

57

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4-methoxytrityl)-2'-O-methyl N-(isobutyryl)-guanosine

ANP-5757

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4-methoxytrityl)-2'-O-methyl-N-benzoyl-adenosine

ANP-5756

93

3'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-methyl-thymidine

ANP-5514

49

3',5'-Bis(2-cyanoethyl diisopropylphosphoramidite)-2'-deoxy-N-acetyl-cytidine

ANP-7762

49

3',5'-Bis(2-cyanoethyl diisopropylphosphoramidite)-2'-deoxy-N-benzoyl-adenosine

ANP-7761

49

3',5'-Bis(2-cyanoethyl diisopropylphosphoramidite)-2'-deoxy-N-isobutyryl-guanosine

ANP-7763

49

3',5'-Bis(2-cyanoethyl diisopropylphosphoramidite)-thymidine

ANP-7764

49

3’-(2-Cyanoethyl diisopropylphosphoramidite)-2’deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-(tert-butyldithiopropyl)-O6-trimethylsilylethyl-guanosine

ANP-6445

40

3’-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza7-cyano-N-benzoyl-adenosine

ANP-7306

83

3’-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza-Nisobutyryl-guanosine

ANP-730183

3’-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5-methyl-uridine

ANP-5600

96

5'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-3'-O-(4,4’-dimethoxytrityl)-2'-fluoro-uridine

ANP-819479

5'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-3'-O-(4,4’-dimethoxytrityl)-7-deaza-N-isobutyryl-guanosine

ANP-4679

34

5'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N-benzoyl-cytidine

ANP-4672

10

5'-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-3'-O-(4,4'-dimethoxytrityl)-N-phenoxy acetyl-adenosine

ANP-4681

105'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza-Nisobutyryl-guanosine

ANP-7102

83

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

ANP-3404

68

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl N-(isobutyryl)-guanosine

ANP-1014

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-methyl-N-bezoyl-cytidine

ANP-1016

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5-methyl-uridine

ANP-1017

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-acetyl-cytidine

ANP-1019

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-benzoyl-adenosine

ANP-1012

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-N-benzoyl-cytidine

ANP-1013

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-uridine

ANP-1015

109

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4’-dimethoxytrityl)-thymidine

ANP-4674

10

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-(N,N’-dimethylformamidine)-guanosine

ANP-4678

10

5'-(2-Cyanoethyl diisopropylphosphoramidite)-3'-O-(4,4'-dimethoxytrityl)-2'-deoxy-N-acetyl-cytidine.

ANP-4675

10

5'-(2-Cyanoethyl diisopropylphosphoramidite)-5'-O-(4-monomethoxytrityl)-thymidine

ANP-5561

3

5’-(2-Cyanoethyl diisopropylphosphoramidite)-2'-deoxy-3'-O-(4,4’-dimethoxytrityl)-2'-fluoro-N-acetyl-cytidine

ANP-819279

6-(2 Cyanoethyl diisopropylphosphoramidite-5'-O-(4,4'-dimethoxytrityl)-3’-O-(succinylamidohexan-thymidine

CLP-2244130

6-Chloro-7-deaza-guanine

BS-1011181

6-Chloro-7-deaza-purine

RP-1021181

6-Chloro-guanine

RN-1051

181

6-Chloro-purine

RN-1030

181236

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INDEX-2: IUPAC Name, C
Product Name

Catalog#

Page#

6-Chloro-purine-riboside

RP-6649

150

C12 Spacer CE phosphoramidite; DMTr-Dodecane-diol Phosphoramidite

CLP-1114

124

C12 Spacer CE phosphoramidite; DMTr-Tetraethyloxy-glycol Phosphoramidite

CLP-1368

125

C18 Spacer CE phosphoramidite; DMTr-Hexa-ethyloxy-glycol Phosphoramidite

CLP-9765

125

C2 Spacer CE phosphoramidite; DMTr-Ethane-diol Phosphoramidite

CLP-2250

124

C3 Spacer CE phosphoramidite; DMTr-Propane-diol Phosphoramidite

CLP-9908

124

C4 Spacer CE phosphoramidite; DMTr-Butane-diol Phosphoramidite

CLP-9775

124

C4 Spacer polystyrene; DMTr-Butanol Polymeric Support

N-9168-05/10

124

C5 Spacer CE phosphoramidite; DMTr-pentane-Diol Phosphoramidite

CLP-9901

126

C6 Spacer CE phosphoramidite; DMTr-Hexane-Diol Phosphoramidite

CLP-1120

124

C9 Spacer CE phosphoramidite; DMTr-Nonane-Diol Phosporamidite

CLP-9009

124

C9 Spacer CE phosphoramidite; DMTr-Triethyloxy-Glycol Phosphoramidite

CLP-1113

125

CAP A (Acetic Anhydride/Pyridine/THF), ABI 3900 Oligonucleotide Synthesizer

RN-1458

21

CAP A (Acetic Anhydride/Pyridine/THF), ABI Oligonucleotide Synthesizers

RN-1458

20

CAP A (Acetic Anhydride/Pyridine/THF), Expedite Oligonucleotide Synthesizer

RN-1458

23

CAP A (Acetic Anhydride/Pyridine/THF),MerMade Oligonucleotide Synthesizer

RN-1458

24

CAP A (Acetic Anhydride/Pyridine/THF),PolyPlex Oligonucleotide Synthesizer

RN-1458

25

Cap A (N-Methyl imidazole; 20% in Acetonitrile) Akta Oligonucleotide Synthesizer

RN-2202

22

CAP B (10% N-Methylimidazole/THF), ABI 3900 Oligonucleotide Synthesizer

RN-148121

CAP B (10% N-Methylimidazole/THF), ABI Oligonucleotide Synthesizer

RN-148120

CAP B (10% N-Methylimidazole/THF), Expedite Oligonucleotide Synthesizer

RN-148123

CAP B (10% N-Methylimidazole/THF), MerMade Oligonucleotide Synthesizer

RN-148124

CAP B (10% N-Methylimidazole/THF),PolyPlex Oligonucleotide Synthesizer

RN-148125

CAP B (16% N-Methylimidazole/THF), ABI 3900 Oligonucleotide Synthesizer

RN-7776

21

CAP B (16% N-Methylimidazole/THF), ABI Oligonucleotide Synthesizer

RN-7776

20

CAP B (16% N-Methylimidazole/THF), Expedite Oligonucleotide Synthesizer

RN-7776

23

CAP B (16% N-Methylimidazole/THF), MerMade Oligonucleotide Synthesizer

RN-7776

24

CAP B (16% N-Methylimidazole/THF), PolyPlex Oligonucleotide Synthesizer

RN-7776

25

Cap B1 (Acetic Anhydride; 40% (v:v) in Acetonitrile) Akta Oligonucleotide Synthesizer

RN-2217

22

Cap B2 (Symmetrical Collidine; 60% (v:v) in Acetonitrile, Akta Oligonucleotide Synthesizer

RN-2225

22

Capping Reagent for ABI Synthesizers (Isopropyl Phosphite/Acetonitrile/Pyridine)

RN-6645-IP

19

Carboxy-dT CEP, C-5 Carboxy Introducing Amidite; Deoxy-uridine-5-Methylacrylate CEP

CLP-2842

130

Carboxyl generating Reagent: Undecanoic CEP

CLP-8146

130

Cartridge-L (Puri-PakTM) for DNA purification

CSS-3920-L

54

Cartridge-M (Puri-PakTM) for DNA purification

CSS-3920-M

54

Cartridge-S (Puri-PakTM), for DNA purification

CSS-3920-S

54

Cartridges for RNA Purification

CSS-5272-02

91

Cholesterol (Plant) TEG CEP

CLP-2795

131

Cholesterol (TEG) CEP (Generates DMT color)

CLP-2703

131

Cholesterol C4 lcaa CPG

N-9267-05

131

Cholesterol lcaa CPG

N-9166-05

131

Cocktail for tetramethylrhodamine (TAMRA)

RN-8561

137

Cyanoethyl-dichlorophosphite

RN-8883

179

Cytidine

RP-1184

149

Cyclic Dithiolane Disulfide Phosphoramidite

CLP-8407

127

Cyclic Dithiolane Disulfide lcaa CPG

N-8408-05/10

127

237

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial
Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

RN-1521180

2-(6-O-(4,4'-dimethoxytrityl)hexyl)-1,3-dioxoisoindoline-5-carboxyl(lcaa-CPG)

N-8217-05/10

123

2',3'-Dideoxy-5-iodo-cytidine

DDN-1731

141

2',3'-Dideoxy-5-iodo-uridine

DDN-1884

141

2',3'-Dideoxy-5-propargylamine-cytidine-5’-triphosphate

NTP-5318

191

2',3'-Dideoxy-5-propargylamine-cytidine-5’-triphosphate (sodium salt)

NTP-5316

191

2',3'-Dideoxy-5-propargylamine-uridine-5’-triphosphate (sodium salt)

NTP-5317

191

2',3'-Dideoxy-7-deaza-7-iodo-adenosine

DDN-3818

141

2',3'-Dideoxy-7-deaza-7-iodo-guanosine

DDN-3819

141

2',3'-Dideoxy-7-deaza-7-propargylamine-adenosine-5’-triphosphate

NTP-6311

191

2',3'-Dideoxy-7-deaza-7-propargylamine-adenosine-5’-triphosphate (sodium salt)

NTP-6312

191

2',3'-Dideoxy-7-deaza-7-propargylamine-guanosine-5’-triphosphate (sodium salt)

NTP-6313

191

2’-Deoxy-5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-adenosine

N-5131-05

104

2’-Deoxy-5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-cytidine

N-5132-05

104

2’-Deoxy-5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-guanosine

N-5133-05

104

2’-Deoxy-5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-thymidine

N-5134-05

104

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-5-iodo-uridine

PM-2864

171

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-5-methyl-N-benzoyl-cytidine

PM-1967168

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-5-propynyl-N-benzoyl-cytidine

PM-1124

168

2’-Deoxy-5'-O-(4,4’-Dimethoxytrityl)-5-propynyl-uridine

PM-1022168

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza- N-isobutyryl-guanosine

PM-6433

169

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-inosine

PM-6434

169

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-7-deaza-N-benzoyl-adenosine

PM-6431169

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-(N,N’-dibutylformamidine)-iso-guanosine

PM-1643

168

2’-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-methyl-adenosine

PM-1107168

2’-Deoxy-7-deaza-adenosine-5’-monophosphate

NMP-8435

186

2’-Deoxy-7-deaza-adenosine-5’-triphosphate (sodium salt)

NTP-4384

189

2’-Deoxy-N1-methyl-adenosine-5’-monophosphate

NMP-8431

186

2’-Deoxy-N3-methyl-cytidine-5’-monophosphate

NMP-8432

186

2’-Deoxy-N-methyl-adenosine-5’-monophosphate

NMP-8433

186

2'-Deoxy -5'-O-(4,4’-dimethoxytrityl)-N-benzoyl-cytidine-3'-O-{P(=O)(CNEt)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-2'’-deoxy-N-benzoyl-cytidine (Dimer)

ANP-2506-CE

13

2'-Deoxy- β-L-guanosine

DN-8233146

2'-Deoxy-2'-fluoro-adenosine

RP-1220150

2'-Deoxy-2'-fluoro-cytidine

RP-1218150

2'-Deoxy-2'-fluoro-guanosine

RP-1219150

2'-Deoxy-2'-fluoro-uridine

RP-1217150

2'-Deoxy-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-5-methyl-N-(N,N’-dimethylformamidine)cytidine

ANP-642228

2'-Deoxy-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-5-methyl-N-benzoyl-cytidine

ANP-642128

2'-Deoxy-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-N1-methyl-N-(N,N’-dimethylformamidine)guanosine

ANP-6122

38

2'-Deoxy-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4’-dimethoxytrityl)-N6-fluorenylmethyloxycarbonyl-N1-methyl-adenosine

ANP-6121

38

2'-Deoxy-3'-(2-cyanoethyl diisopropylphosphoramidite)-5'-O-(4,4'-dimethoxytrityl)-N-benzoyl-β-L-adenosine

ANP-8031

44

2'-Deoxy-3’-O-levulinyl-N-benzoyl-adenosine

PM-6611164

2'-Deoxy-3’-O-levulinyl-N-benzoyl-cytidine

PM-6612164238

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INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

2'-Deoxy-3’-O-levulinyl-N-isobutyryl-guanosine

PM-6613164

2'-Deoxy-3'-O-(4,4'-dimethoxytrityl)-5'-O-succinyl(lcaa-CPG)-N-benzoyl-cytidine

N-3352-05/10

102'-Deoxy-3'-O-(4,4'-dimethoxytrityl)-5'-O-succinyl(spacer-polystyrene)-N-benzoyl-cytidine

N-7519-03

112'-Deoxy-3'-O-levulinyl-guanosine

DN-1267147

2'-Deoxy-4-thiouridine

DN-1263145

2'-Deoxy-5’-O-levulinyl-N-benzoyl-adenosine

DN-6601164

2'-Deoxy-5’-O-levulinyl-N-benzoyl-cytidine

DN-6602164

2'-Deoxy-5-aza-cytidine

DN-1771147

2'-Deoxy-5-iodo-cytidine

DN-1181143

2'-Deoxy-5-iodo-uridine

DN-1180143

2'-Deoxy-5-methyl-cytidine

DN-2013132

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)- 3'-O-succinyl(lcaa-CPG)-8-oxo-N-(N,N’-dimethylformamidine)-guanosine

N-9501-05/10

472'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-deoxy-N-benzoyl-cytidine-3'-O-{P(=O)(CNEt)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-2'’-deoxy-N-benzoyl-adenosine (Dimer)

ANP-2505-CE

13

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-deoxy-N-benzoyl-cytidine-3'-O-{P(=O)(CNEt)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-2'’-deoxy-N-isobutyryl-guanosine (Dimer)

ANP-2507-CE

13

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-deoxy-N-benzoyl-cytidine-3'-O-{P(=O)(CNEt)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-thymidine (Dimer)

ANP-2508-CE

13

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-3'-O-succinyl(lcaa-CPG)-N-(isobutyryl)-guanosine

N-1055-05

78

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-3'-O-succinyl(lcaa-CPG)-N-(N,N’-dimethylformamidine)-adenosine

N-1067-05

78

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-3'-O-succinyl(lcaa-CPG)-N-(N,N’-dimethylformamidine)-guanosine

N-1069-05

78

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-3'-O-succinyl(lcaa-CPG)-N-acetyl-cytidine

N-1057-05

78

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-3'-O-succinyl(lcaa-CPG)-N-benzoyl-adenosine

N-1058-05

78

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-2'-fluoro-3'-O-succinyl(lcaa-CPG)-uridine

N-1056-05

78

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(2-ethyl diisopropylphosphoramidite)-N-benzoyl-adenosine

ANP-6541

103

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-6-O-(N,N-diphenylcarbamoyl)-N-isobutyrylguanosine

ANP-9277

40

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-(tertbutylphenoxyacetyl)-guanosine

ANP-5533

107

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-acetyl-cytidine

ANP-3769

82'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-benzoyl adenosine

ANP-3761

82'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-benzoyl-cytidine

ANP-3762

82'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-dimethylacetamidine-guanosine

ANP-3768

82'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-isobutyryl-guanosine

ANP-3763

82'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-phenoxyacetyl-adenosine

ANP-5531

107

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-phenoxyacetyl-cytidine

ANP-5532

107

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-H-phosphonate-N- isobutyryl-guanosine (TEA salt)

ANP-3412

142'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-H-phosphonate-N-acetyl-cytidine (TEA salt)

ANP-3414

142'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-H-phosphonate-N-benzoyl-adenosine (TEA salt)

ANP-3410

142'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-H-phosphonate-N-benzoyl-cytidine (TEA salt)

ANP-3411

142'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-( N,N’-diisopropyl-1-methylphosphinamine)-inosine

ANP-7558

105

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-N-benzoyl-adenosine

ANP-7551

105

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-N-isobutyryl-cytidine

ANP-7556

105

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-N-isobutyryl-guanosine

ANP-7553

105

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-uridine

ANP-7557

105

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2-fluoro-O6-trimethylsilylethyl-inosine

N-9926-05/10

402'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-5-fluoro-uridine

N-7365-05/10

372'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-5-Iodo-N-(N,N’-dibutylformamidine)-cytidine

N-7363-05/10

37

239

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-5-iodo-N-benzoyl-cytidine

N-4612-05/10

372'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-5-iodo-uridine

N-7364-01/10

372'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-5-methyl-N-(N,N’-dimethylformamidine)-cytidine

N-1355-05/10/20

28

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-5-methyl-N-benzoyl-cytidine

N-1353-05/10/20

28

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-7-deaza-inosine

N-8779-05/10

33

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-7-deaza-N-benzoyl-adenosine

N-8777-05/10

33

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-7-deaza-N-isobutyryl-guanosine

N-8778-05/10

33

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-8-methyl-N-isobutyryl-guanosine

N-9924-05/10

412'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-8-oxo-N-acetyl-guanosine

N-9400-05/10

46

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-8-oxo-N-benzoyl-adenosine

N-5300-05/10

46

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-(N,N’-dibutylformamidine)-iso-cytidine

N-9929-05/10

432'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-(N,N’-dibutylformamidine)-iso-guanosine

N-9927-05/10

432'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-(N,N’-dimethylformamidine)-guanosine

N-9898-05/10/20

42'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N1-methyl-N-(N,N’-dimethylformamidine)-guanosine

N-9981-05/10

39

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N6-fluorenylmethyloxycarbonyl-N1-methyl-adenosine

N-9980-05/10

39

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-isobutyryl-cytidine

N-5112-05/10/20

42'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-phenoxyacetyl-cytidine

N-P5102-05/10/20

62'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-inosine

PM-1119166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-benzoyl-cytidine

PM-1110166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-cyanoethyl-cytidine

PM-1489168

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-fluorenylmethyloxycarbonyl-cytidine

PM-4322166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-fluorenylmethyloxycarbonyl-guanosine

PM-4333

166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isobutyryl-cytidine

PM-1117166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isobutyryl-guanosine

PM-1111166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isobutyryl-guanosine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-N-benzoyl-adenosine (Dimer)

ANP-2509-CE

13

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isobutyryl-guanosine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-N-isobutyryl-guanosine (Dimer)

ANP-2511-CE

132'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isobutyryl-guanosine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl
diisopropylphosphoramidite)-thymidine (Dimer)

ANP-2512-CE

132'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-isopropylphenoxyacetyl-guanosine

PM-1484

166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-phenoxyacetyl-cytidine

PM-3102166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-phenoxyacetyl-guanosine

PM-3103166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-N-tertbutylphenoxyacetyl-guanosine

PM-1483

166

2'-Deoxy-5'-O-(4,4’-dimethoxytrityl)-uridine

PM-1120166

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)- 3’-O-succinyl(lcaa-CPG)-N-benzoyl-β-L-adenosine

N-3521-05/10

46

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-N-acetyl-β-L-cytidine

N-3525-05/10

46

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-N-benzoyl-β-L-cytidine

N-3522-05/10

46

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-N-isobutyryl-β-L-guanosine

N-3523-05/10

46

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-N-phenoxy acetyl-adenosine

N-P5101-05/10/20

62'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-benzoyl-cytidine

N-5102-05/10/20

42'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-benzoyl-α-D-adenosine

N-1751-05/10/20

30

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-benzoyl-α-D-cytidine

N-1752-05/10/20

30

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-isobutyryl-α-D-guanosine

N-1753-05/10/20

30

2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(non-clevable spacer inert support)-N-benzoyl-cytidine

N-7522-15/60/10-60

162'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-3'-O-succinyl(spacer-polystyrene)-N-benzoyl-cytidine

N-7512-03

152'-Deoxy-5'-O-(4-methoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-(tertbutylphenoxyacetyl)-guanosine

ANP-5537

107

240

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INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

2'-Deoxy-5'-O-(4-methoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-benzoyl adenosine

ANP-3766

82'-Deoxy-5'-O-(4-methoxytrityl)-3'-(methyl diisopropylphosphoramidite)-N-isobutyryl-guanosine

ANP-3767

82'-Deoxy-5'-O-(4-methoxytrityl)-3’-(methyl diisopropylphosphoramidite)-N-phenoxyacetyl-adenosine

ANP-5536

107

2'-Deoxy-5-propynyl-cytidine

DN-1541145

2'-Deoxy-5-propynyl-uridine

DN-1846145

2'-Deoxy-6-thio-guanosine

DN-1269

145

2'-Deoxy-7-deaza-7-iodo-guanosine

DN-2563148

2-Deoxy-7-deaza-guanosine-5’-triphosphate (sodium salt)

NTP-4386

189

2'-Deoxy-7-deaza-O6-methyl-guanosine

DN-1147148

2'-Deoxy-8-oxo-guanosine

DN-1205142

2'-Deoxy-adenosine (Monohydrate)

DN-1001140

2'-Deoxyadenosine (N-PAC)-5'-O-DMTr-3'-CEP (repeated)

ANP-6661

7

2'-Deoxy-cytidine (Free Base)

DN-1002fb

140

2'-Deoxycytidine (N-Ac)-5'-O-DMTr-3'-CEP (repeated)

ANP-5560

72'-Deoxy-cytidine monohydrate

DN-10021402'-Deoxy-iso-guanosine

DN-1268147

2'-Deoxy-N-(N,N’-dimethylformamidine)-guanosine

PM-3183160

2'-Deoxy-N1-methyl-adenosine

DN-1597

144

2'-Deoxy-N1-methyl-guanosine

DN-1598

144

2'-Deoxy-N3-methyl-cytidine

DN-6493

144

2'-Deoxy-N-benzoyl-cytidine

PM-1102160

2'-Deoxy-N-isobutyryl-cytidine

PM-1104160

2'-Deoxy-N-isobutyryl-guanosine

PM-1103157

2'-Deoxy-N-methyl-adenosine

DN-2015144

2'-Deoxy-N-methyl-cytidine

DN-2016144

2'-Deoxy-N-methyl-uridine

DN-6495

144

2'-Deoxy-N-phenoxy acetyl-adenosine

PM-9996160

2'-Deoxy-N-phenoxyacetyl-cytidine

PM-9997160

2'-Deoxy-O6-carboxymethyl-guanosine (calcium Salt)

DN-2019145

2'-Deoxy-α-D-adenosine

DN-6351146

2'-Deoxy-α-D-cytidine

DN-6352146

2'-deoxy-α-D-guanosine

DN-6353146

2'-Deoxy-β-L-adenosine

DN-8231146

2'-Deoxy-β-L-cytidine

DN-8232146

2'-Deoxy-β-L-uridine

DN-8235146

2'-Dideoxy-7-deaza-7-iodo-adenosine

DN-2561148

3'-Deoxy­-5'-O-(4,4'-dimethoxytrityl)-2’-O-succinyl(lcaa-CPG)-N-benzoyl-β-L-cytidine

N-4062-05/10

46

3'-O-(4,4’-Dimethoxytrityl)- 5'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-benzoyl-cytidine

N-9913-05/10

110

3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5’-O-succinyl(lcaa-CPG)-uridine

N-9915-05/10

110

3'-O-(4,4’-dimethoxytrityl)-2'-O-methyl-5'-O-succinyl(lcaa-CPG)-5-methyl-uridine

N-9917-05/10

110

3'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5'-O-succinyl(lcaa-CPG)-N-(isobutyryl)-guanosine

N-9914-05/10

110

3'-O-(4,4’-Dimethoxytrityl)-5'-O-succinyl(lcaa)-thymidine

N-3354-05/10

103'-O-(4,4’-Dimethoxytrityl)-5'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

N-6204-05/10

67

3'-O-(4,4’-Dimethoxytrityl)-5'-O-succinyl(lcaa-CPG)-2'-O-methyl-5-methyl-N-benzoyl-cytidine

N-9916-05/10

110

3'-O-(4,4’-Dimethoxytrityl)-5'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-acetyl-cytidine

N-9919-05/10

110

241

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33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

3'-O-(4,4’-Dimethoxytrityl)-5'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-benzoyl-adenosine

N-9912-05/10

110

5'-O-(4,4’-Dimethoxytrityl)- 3'-(Non-clevable long chain spacer)-thymidine

N-7524-15/60/10-60

165'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N- phenoxyacetyl-guanosine

N-5143-05

61

5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-adenosine

N-5141-05

61

5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-cytidine

N-5142-05

61

5'-O-(4,4’-Dimethoxytrityl)- 3'-O-oxalyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

N-5144-05

61

5'-O-(4,4’-Dimethoxytrityl)- 3'-O-succinyl(lcaa)-thymidine

N-5104-05/10/20

45'-O-(4,4’-Dimethoxytrityl)- 3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-5-methyl-N-benzoyl-cytidine

N-9822-05/10

75

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-(N,N’-dimethylformamidine)-guanosine

PM-5859

174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N,N’-dibenzoyl-adenosine

PM-5857

174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-acetyl-cytidine

PM-5856

174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-adenosine

PM-5851

174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-cytidine

PM-5852

174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-isobutyryl-guanosine

PM-5853

174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-adenosine

PM-3501174

5'-O-(4,4’-Dimethoxytrityl)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl-cytidine

PM-3502

174

5'-O-(4,4’-Dimethoxytrityl)-2’-deoxy-5-iodo-N-(N,N’-dibutylformamidine)-cytidine

PM-1979

171

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl- N-phenoxyacetyl-guanosine

PM-3703

172

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-(ethyl diisopropylphosphoramidite)-N-isobutyryl-guanosine

ANP-7223

100

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-(ethyl diisopropylphosphoramidite)-N-phenoxyacetyl-adenosine

ANP-7227101

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-(ethyl diisopropylphosphoramidite)-N-phenoxyacetyl-guanosine

ANP-7226

101

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-(ethyl diisopropylphosphoramidite)-thymidine

ANP-7224

100

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-(ethyl diisopropylphosphoramidite)-uridine

ANP-7225

100

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-5-bromo-uridine

N-9011-05/10

98

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-5-iodo-uridine

N-9012-05/10

98

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-5-methyl-N-(N,N’-dimethylformamidine)-cytidine

N-1613-05/10

98

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-5-methyl-N-bezoyl-cytidine

N-1613Bz-05/10

98

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-N-(isobutyryl)-guanosine

N-7912-05/10

94

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-N-(N,N’-dimethylformamidine)-guanosine

N-7914-05/10

94

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl3'-O-succinyl(lcaa-CPG)-N-(phenoxyacetyl)guanosine

N-P7903-05/10

95

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-uridine

N-7904-05/10

94

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5-methyl-N-benzoyl-cytidine

PM-3705

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5-methyl-uridine

PM-3706

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5-propynyl-N-benzoyl-cytidine

PM-1129

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-5-propynyl-uridine

PM-1027

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-N-acetyl-cytidine

PM-5735

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-N-benzoyl-adenosine

PM-5731173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-N-benzoyl-cytidine

PM-5732

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-N-isobutyryl-guanosine

PM-5733

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-N-phenoxyacetyl-adenosin

PM-3701

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-N-phenoxyacetyl-cytidine

PM-3702

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-methyl-uridine

PM-5734

173

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-1,1-dihydro-ribose

N-9784-05/10

114

242

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INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-inosine

N-8970-05/10

112

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-N-acetyl-cytidine

N-8960-05/10

112

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-N-benzoyl-adenosine

N-8910-05/10

112

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-N-benzoyl-cytidine

N-8920-05/10,

112

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-N-isobutyryl-guanosine

N-8930-05/10

112

5'-O-(4,4’-Dimethoxytrityl)-2'-O-propargyl-3'-O-succinyl(lcaa-CPG)-uridine

N-8940-05/10

112

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-ethyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyladenosine

ANP-413189

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-ethyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetylcytidine

ANP-4132

89

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-ethyl diisopropylphosphoramidite)-2'-O-methyl-N-benzoyl-cytidine

ANP-7222

100

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-ethyl diisopropylphosphoramidite)-2'-O-methyl-N-phenoxyacetyl-cytidine

ANP-7228101

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-isopropyl diisopropylphosphoramidite)-2'-deoxy-N-benzoyl-adenosine

ANP-6901

107

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-isopropyl diisopropylphosphoramidite)-2'-deoxy-N-benzoyl-cytidine

ANP-6902

107

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-isopropyl diisopropylphosphoramidite)-2'-deoxy-N-isobutyryl-guanosine

ANP-6903

107

5'-O-(4,4’-Dimethoxytrityl)-3'-(2-isopropyl diisopropylphosphoramidite)-hymidine

ANP-6904

107

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl adenosine

ANP-5691

65

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-cytidine

ANP-5692

65

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-isobutyrylguanosine

ANP-5693

65

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetyl
adenosine

ANP-3861

66

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetylcytidine

ANP-3862

66

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-N-phenoxyacetylguanosine

ANP-3863

66

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

ANP-5694

64

5'-O-(4,4’-Dimethoxytrityl)-3'-(methyl diisopropylphosphoramidite)-thymidine

ANP-3764

85'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-acetyl-cytosine

PM-5866

175

5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-adenosine

PM-5861

175

5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-cytidine

PM-5862

175

5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-N-isobutyryl-guanosine

PM-5863

175

5'-O-(4,4’-Dimethoxytrityl)-3'-(tert-butyl(methoxy)dimethylsilane)-uridine

PM-5864

175

5'-O-(4,4’-Dimethoxytrityl)-3'-H-phosphonate-thymidine (TEA salt)

ANP-3413

145'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-2'-O-methyl-N-acetyl-cytidine

ANP-8556

106

5'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-2'-O-methyl-N-benzoyl-adenosine

ANP-8551

106

5'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-2'-O-methyl-N-benzoyl-adenosine

ANP-7221100

5'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-2'-O-methyl-N-isobutyryl-cytidine

ANP-8552

106

5'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-2'-O-methyl-N-isobutyryl-guanosine

ANP-8553

106

5'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-2'-O-methyl-uridine

ANP-8554

106

5'-O-(4,4’-Dimethoxytrityl)-3'-O-(N,N’-diisopropyl-1-methylphosphinamine)-thymidine

ANP-7554

102

5'-O-(4,4’-Dimethoxytrityl)-3'-O-methyl-2'-O-succinyl(lcaa-CPG)-inosine

N-8814-05/10

102

5'-O-(4,4’-Dimethoxytrityl)-3'-O-methyl-2'-O-succinyl(lcaa-CPG)-N-(isobutyryl)-guanosine

N-8812-05/10

102

5'-O-(4,4’-Dimethoxytrityl)-3'-O-methyl-2'-O-succinyl(lcaa-CPG)-N-benzoyl-adenosine

N-8810-05/10

102

5'-O-(4,4’-Dimethoxytrityl)-3'-O-methyl-2'-O-succinyl(lcaa-CPG)-N-benzoyl-cytidine

N-8811-05/10

102

5'-O-(4,4’-Dimethoxytrityl)-3'-O-methyl-2'-O-succinyl(lcaa-CPG)-uridine

N-8813-05/10

102

5'-O-(4,4’-Dimethoxytrityl)-3'-O-propargyl-2'-O-succinyl(lcaa-CPG)-N-acetyl-cytidine

N-9889-05/10

113

5'-O-(4,4’-Dimethoxytrityl)-3'-O-propargyl-2'-O-succinyl(lcaa-CPG)-N-benzoyl-adenosine

N-9881-05/10

113

243

Toll Free: (800) 762-9323
Toll Free:33(800)762-9323
Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, D
Product Name :Catalog#Page#

5'-O-(4,4’-Dimethoxytrityl)-3'-O-propargyl-2'-O-succinyl(lcaa-CPG)-N-benzoyl-cytidine

N-9882-05/10

113

5'-O-(4,4’-Dimethoxytrityl)-3'-O-propargyl-2'-O-succinyl(lcaa-CPG)-N-isobutyryl-guanosine

N-9883-05/10

113

5'-O-(4,4’-Dimethoxytrityl)-3'-O-propargyl-2'-O-succinyl(lcaa-CPG)-uridine

N-9884-05/10

113

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl (spacer-polystyrene)-2'-(tert-butyl(methoxy)dimethylsilane-uridine

N-6214-03

64

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane inosine

N-8370-05/10

75

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-(N-tertbutylphenoxyacetyl)guanosine

N-6208-05/10

60

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-5-fluoro uridine

N-9832-05/10

85

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-5-iodo-N-benzoyl-cytidine

N-9893-05/10

85

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-5-iodo-uridine

N-9809-05/10

85

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza-N-benzoyl-adenosine;(Tubercidin Supports)

N-9897-05/10

83

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-7-deaza-N-isobutyryl-guanosine

N-9895-05/10

83

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-8-methyl-N-isobutyryl-guanosine

N-9909-05/10

73

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-(N,N’-dibutylformamidine)-isoguanosine

N-9827-05/10

86

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N3-benzothioethyl-uridine

N-9828-05/10

73

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-isopentenyl-adenosine

N-9060-05/10

75

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-methyl-ribo-thymidine

N-9816-05/10

73

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-methyl-uridine

N-9814-05/10

73

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-purine-riboside Nebularine CPG

N-9080-05/10

79

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-pyridine-2-one-riboside;
Zebularine CPG

N-9020-05/10

76

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-ribothymidine

N-8477-05/10

74

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

N-6104-05/10/20

58

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-uridine

N-P6104-05/10

60

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2’-O-(triisopropyl-siloxymethyl)- N-acetyl-guanosine

N-3203-05/10

69

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2’-O-(triisopropyl-siloxymethyl)-N-acetyl-adenosine

N-3201-05/10

69

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2’-O-(triisopropyl-siloxymethyl)-N-acetyl-cytidine

N-3202-05/10

69

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2’-O-(triisopropyl-siloxymethyl)-uridine

N-3205-05/10

69

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-deoxy-4-thio-uridine

N-9758-05/10

27

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-inosine

N-9013-05/10

98

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-acetyl-cytidine

N-7905-05/10

94

5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-benzoyl-adenosine

N-7910-05/10

94

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-benzoyl-cytidine

N-7911-05/10

94

5'-O-(4,4’-dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-phenoxyacetyl-adenosine

N-P7901-05/10

95

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-N-phenoxyacetyl-cytidine

N-P7902-05/10

95

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-2'-O-methyl-ribothymidine

N-5601-05/10

98

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-4-thio-thymidine

N-9925-05/10

27

5'-O-(4,4’-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-N-methyl-thymidine

N-9922-05/10

39

5'-O-(4,4’-Dimethoxytrityl)-5-methyl-N-benzoyl-cytidine

PM-2647

172

5'-O-(4,4’-Dimethoxytrityl)-5-propynyl-N-benzoyl-cytidine

PM-1126

172

5'-O-(4,4’-Dimethoxytrityl)-5-propynyl-uridine

PM-1024

172

5'-O-(4,4’-Dimethoxytrityl)-inosine

PM-2306

167

5'-O-(4,4’-Dimethoxytrityl)-N-acetyl-cytidine

PM-2114167

5'-O-(4,4’-Dimethoxytrityl)-N-acetyl-guanosine

PM-4003

167

5'-O-(4,4’-Dimethoxytrityl)-N-benzoyl-adenosine

PM-2109167244

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INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

5'-O-(4,4’-Dimethoxytrityl)-N-benzoyl-cytidine

PM-2110167

5'-O-(4,4’-Dimethoxytrityl)-N-fluorenylmethyloxycarbonyl-adenosine

PM-4366

167

5'-O-(4,4’-Dimethoxytrityl)-N-fluorenylmethyloxycarbonyl-cytidine

PM-4367

167

5'-O-(4,4’-Dimethoxytrityl)-N-fluorenylmethyloxycarbonyl-guanosine

PM-4368

167

5'-O-(4,4’-Dimethoxytrityl)-N-isobutyryl-cytidine

PM-2113167

5'-O-(4,4’-Dimethoxytrityl)-N-isobutyryl-guanosine

PM-2111167

5'-O-(4,4’-Dimethoxytrityl)-N-isopropyl-phenoxyacetyl-guanosine

PM-2209

167

5'-O-(4,4’-Dimethoxytrityl)-N-methyl-thymidine

PM-1591

168

5'-O-(4,4’-Dimethoxytrityl)-N-phenoxyacetyl guanosine

PM-2205

167

5'-O-(4,4’-Dimethoxytrityl)-N-phenoxyacetyl-adenosine

PM-2203

167

5'-O-(4,4’-Dimethoxytrityl)-N-phenoxyacetyl-cytidine

PM-2204

167

5'-O-(4,4’-Dimethoxytrityl)-ribothymidine

PM-2115167

5'-O-(4,4’-Dimethoxytrityl)-thymidine

PM-1112166

5'-O-(4,4’-Dimethoxytrityl)-thymidine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl diisopropylphosphoramidite)-2'’deoxy-N-benzoyl-adenine (Dimer)

ANP-2513-CE

135'-O-(4,4’-Dimethoxytrityl)-thymidine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl diisopropylphosphoramidite)-2'’deoxy-N-benzoyl-cytidine (Dimer)

ANP-2514-CE

135'-O-(4,4’-Dimethoxytrityl)-thymidine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl diisopropylphosphoramidite)-2'’deoxy-N-isobutyryll-guanosine (Dimer)

ANP-2515-CE

135'-O-(4,4’-Dimethoxytrityl)-thymidine-3'-O-{P(=O)(cyanoethyl)}-O-5''-3'’-(2-cyanoethyl diisopropylphosphoramidite)-thymidine (Dimer)

ANP-2516-CE

135'-O-(4,4’-Dimethoxytrityl)-uridine

PM-2112167

5'-O-(4,4'-dimethoxytrityl)- 2'-O-methyl-3'-O-succinyl(lcaa-CPG)-N-acetyl-ara-cytidine

N-7425-05/10

111

5'-O-(4,4'-dimethoxytrityl)- 2'-O-methyl-3'-O-succinyl(lcaa-CPG)-N-benzoyl-ara-adenosine

N-7423-05/10

111

5'-O-(4,4'-dimethoxytrityl)- 2'-O-methyl-3'-O-succinyl(lcaa-CPG)-N-benzoyl-ara-cytidine

N-7424-05/10

111

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-3’-O-succinyl(lcaa-CPG)-N-acetyl-cytidine

N-5212-05/10/20

45'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-3’-O-succinyl(spacer-polystyrene)-N-acetyl-cytidine

N-7515-03

15

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-3’-O-succinyl(spacer-polystyrene)-thymidine

N-7514-03

155'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-ara-uridine

N-7427-05/10

111

5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-3'-O-succinyl(lcaa-CPG)-N-isobutyryl-ara-guanosine

N-7426-05/10

111

5'-O-(4,4'-dimethoxytrityl)-3'-O-(benzyl diisopropylphosphoramidite)-2'-deoxy-N-benzyl-adenosine

ANP-6731

95'-O-(4,4'-dimethoxytrityl)-3'-O-(benzyl diisopropylphosphoramidite)-2'-deoxy-N-benzyl-cytidine

ANP-6732

95'-O-(4,4'-dimethoxytrityl)-3'-O-(benzyl diisopropylphosphoramidite)-2'-deoxy-N-isobutyryl-guanosine

ANP-6733

95'-O-(4,4'-dimethoxytrityl)-3'-O-(benzyl diisopropylphosphoramidite)-thymidine

ANP-6734

95'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-acetyl-β-L-cytidine

N-4696-05/10

88

5'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-β-L-adenosine

N-4691-05/10

88

5'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzoyl-β-L-cytidine

N-4692-05/10

88

5'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-benzyl-adenosine

N-9050-05/10

73

5'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-N-isobutyryl-β-L-guanosine

N-4693-05/10

88

5'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-β-L-ribothymidine

N-4695-05/10

88

5'-O-(4,4'-dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-2'-(tert-butyl(methoxy)dimethylsilane)-β-L-uridine

N-4694-05/10

88

5'-O-(4,4'-Dimethoxytrityl)-3’-O-succinyl(lcaa-CPG)-β-L-thymidine

N-3524-05/10

45

5'-O-(4,4'-Dimethoxytrityl)-3'-O-(N,N,N',N'-tetraisopropylphosphinediamine)-thymidine

ANP-7766

45

5'-O-(4,4'-Dimethoxytrityl)-3'-O-succinyl(lcaa-CPG)-α-D-thymidine

N-1754-05/10/20

30

5'-O-(4,4'-Dimethoxytrityl)-N-Cyanoethyl-thymidine

PM-1490

168

7-Deaza-2',3'-dideoxy-adenosine

DDN-3864

141

7-Deaza-2',3'-dideoxy-guanosine

DDN-1863

141

7-Deaza-2'-deoxy-adenosine

DN-1143148

245

Toll Free: (800) 762-9323
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33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, D
Product Name

Catalog#Page#

7-Deaza-2'-deoxy-guanosine

DN-4567

145

7-Deaza-2'-deoxy-inosine

DN-1145148

7-Deaza-7-iodo-adenosine

RP-2316148

7-Deaza-adenosine; Tubercidin

RP-2312154

7-Deaza-guanosine

RP-2313154

7-Deaza-inosine

RP-2314154

Dabcyl-dT CEP; Thymidine-C5-dabcyl CEP

CLP-9906

132

Dabcyl-lcaa-CPG

N-9756-05/10

132

Dabcyl-succinyl -Polymeric Support

N-9756-PF

132

DDTT ((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazoline-3-thione / Sulfurizing Reagent

RN-1588

178

DDTT Solution 1 [0.05M] (Sulfurizing Reagent), ABI 3900 Oligonucleotide Synthesizers

RN-1688

21

DDTT Solution 1 [0.05M] (Sulfurizing Reagent), MerMade Oligonucleotide Synthesizers

RN-168824

DDTT Solution 1 [0.05M] (Sulfurizing Reagent), PolyPlex Oligonucleotide Synthesizers

RN-168825

DDTT Solution 1 [0.10M] (Sulfurizing Reagent), ABI 3900 Oligonucleotide Synthesizers

RN-1689

21

DDTT Solution 1 [0.10M] (Sulfurizing Reagent), MerMade Oligonucleotide Synthesizers

RN-1689

24

DDTT Solution 1 [0.10M] (Sulfurizing Reagent), PolyPlex Oligonucleotide Synthesizers

RN-168925

Deprotection solution for Levulinyl Removal

CLP-717112, 129

Dichloromethoxy-phosphite

RN-1407179

Diethoxy-N,N-Diisopropyl-phosphoramidite

RN-1410

179

Diethyl-phosphorochloride

RN-1408

180

Diisopropyl-ammonium-1H-tetrazolide

RN-1413176

Dimethoxytrityl-chloride, (DMTr-Chloride)RN-1401177

DMTr Removal Reagent (3% Dichloracetic Acid/Dichloromethane), ABI Oligonucleotide Synthesizer

RN-1468

20

DMTr Removal Reagent (2.5% Dichloracetic Acid/Dichloromethane), Expedite Oligonucleotide Synthesizer

RN-1468

23

DMTr Removal Reagent (2.5% Dichloracetic Acid/Dichloromethane), MerMade Oligonucleotide Synthesizer

RN-1468

24

DMTr Removal Reagent (3% DCA in Toluene) Akta Oligonucleotide Synthesizer

RN-224222

DMTr Removal Reagent (3% Dichloracetic Acid/Dichloromethane), ABI 3900 Oligonucleotide Synthesizer

RN-1468

21

DMTr Removal Reagent (3% Dichloracetic Acid/Dichloromethane), PolyPlex Oligonucleotide Synthesizer

RN-1468

25

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane)

RN-146221

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), ABI Oligonucleotide Synthesizer

RN-146220

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), Expedite Oligonucleotide Synthesizer

RN-146223

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), MerMade Oligonucleotide Synthesizer

RN-146224

DMTr Removal Reagent (3% Trichloracetic Acid/Dichloromethane), PolyPlex Oligonucleotide Synthesizer

RN-1462

25

DMTr-5-FAM-Phosphoramidite

CLP-9789

136

DMTr-6-FAM-Phosphoramidite

CLP-9780

136

DMTr-Butane-diol Phosphoramidite; C4 Spacer CE phosphoramidite

CLP-9775

124

DMTr-Butanol Polymeric Support; C4 Spacer Polymeric Support

N-9168-05/10

124

DMTr-Dodecane-diol Phosphoramidite; C12 Spacer CE phosphoramidite

CLP-1114

124

DMTr-Ethane-diol Phosphoramidite; C2 Spacer CE phosphoramidite

CLP-2250

124

DMTr-Hexa-ethyloxy-glycol Phosphoramidite; C18 Spacer CE phosphoramidite

CLP-9765

125

DMTr-Hexane-diol Phosphoramidite; C6 Spacer CE phosphoramidite

CLP-1120

124

DMTr-Nonane-diol Phosporamidite; C9 Spacer CE phosphoramidite

CLP-9009

124

DMTr-Polyethyleneglycol 2000 CEP; (PEG 2000 CEP)

CLP-2119

125

DMTr-Polyethylenglycol 4500 CEP; PEG 4500 CEP (Avg. M.W.~4500)

CLP-3118

125

DMTr-Propane-diol Phosphoramidite, (C3 Spacer CE phosphoramidite)

CLP-9908

124

246

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INDEX-2: IUPAC Name, D, E
Product Name

Catalog#

Page#

DMTr-Tetraethyloxy-glycol Phosphoramidite; C12 Spacer CE phosphoramidite

CLP-1368

125

DMTr-Triethyloxy-glycol Phosphoramidite, (C9 Spacer CE phosphoramidite)

CLP-1113

125

DNA Purification, 96 Well Collection Plate (Pack of 12)

GS-3280

51

DNA Purification, 96 Well Oligonucleotide Synthesis plate

GS-8361

51

DNA Purification, Puri-Pak PlateTM (Not Shown)

GS-1154

51

DNA Purification, 96 Well Collection Plate (1 Plate)GS-3280

51

DNA Purification, Genesys Manifold for 96-well Format GeneSys-1

GS-8366

51

DNA Purification, Genesys-24 (Not Shown)

GS-1158

51

DNA Purification, Puri-Pak PlateTM

GS-3249

51

DNP-TEG CEP

CLP-9907

132

DNP-TEG-lcaa-CPG

N-9127-05

132

5-FAM CPG

N-9969-05

136

5-Fluorescein CEP; Fluorescein Phosphoramidite

CLP-4282

135

5-Fluorescein-dipivalate-NHS Ester; 5-FAM Dipivalate NHS Ester

RN-9652

182

5-Fluorescein-NHS Ester; 5-FAM NHS Ester

RN-9662

182

6-FAM CPG

N-9985-05

136

6-FAM-lcaa CPG (DMT); 5'-Fluorescein CPG

N-9986-05

135

6-FAM-Phosphoramidite

CLP-9777134

6-Fluorescein-dipivalate- NHS Ester; 6-FAM Dipivalate NHS Ester

RN-9651

182

6-Fluorescein-NHS Ester; 6-FAM NHS Ester

RN-9661

182

Filters (Replacement Filters)

EPC-1008

18

Fluorescein CPG; 3'-Fluorescein CPG

N-9979-05

135

Fluorescein-dT CEP

CLP-9905

135

Fluorescein-dT CPG; 3'-Fluorescein-dT CPG

N-5122-05

135

Fluoride Ion Removal Solution

CSS-6634

91

RP-1185

149

Hexachloro-fluorescein-cyanoethyl phosphoramidite,

CLP-9778

134

Hexachloro-fluorescein-cyclohexyl cyanoethyl phosphoramidite

CLP-1527

134

Hexane-6-carboxyamido (p-benzaldehyde)-1-ol cyanoethyl phosphoramidite

CLP-2243130

H-Phosphonate activation reagent (Dipentafluorophenyl Carbonate)

RN-6464

19

1H-Imidazole-4,5-dicarbonitrile; Dicyanoimidazole (DCI)

RN-1571176

2',3'-Isopropylidene-N-benzoyl-adenosine

RP-4127162

2',3'-Isopropylidene-N-isobutyryl-guanosine

RP-4128162

2',3'-Isopropylidene-uridine

RP-4129162

2’,3’-Isopropylidene-cytidine (N-Ac)

RP-4126

162

E

F

G
Guanosine
H

I

247

Toll Free: (800) 762-9323
Toll Free:(800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
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INDEX-2: IUPAC Name, I, L,M
Product Name

Catalog#

Page#

4-Isopropyl-phenoxy-cetylchloride

RN-1705180

5-Iodo-cytidine

RP-1221151

5-Iodo-uridine

RP-1089

151

InosineRP-1187

149

Iso-guanosine-5’-triphosphate (sodium salt)

NTP-4396

189

Iso-guanosine-5’-triphosphate (sodium salt)

NTP-4348

188

N-isobutyryl-cytidine

PM-2105

161

N-Isobutyryl-guanosine

PM-2103

161

N-Isobutyryl-iso-guanosine-5’-monophosphate

NMP-8318

185

N-Isopentyl-adenosine

PM-6005

161

3’-O-Levulinyl-thymidine

PM-6614164

5’-O-Levulinyl-N-isobutyryl-guanosine

DN-6603

164

5’-O-Levulinyl-thymidine

DN-6604

164

Levulinyl Deprotection Solution

CLP-7171

121,129

β-L-Adenosine

RP-9031154

β-L-Adenosine-5’-monophosphate

NMP-8314

184

β-L-Cytidine

RP-9032

154

β-L-Guanosine

RP-9033

154

β-L-Inosine

RP-9036154

β-L-Ribothymidine

RP-9035

154

β-L-Ribouridine-5’-monophosphate

NMP-8315

184

β-L-Thymidine

DN-8234

146

β-L-Uridine

RP-9034

154

2’-O-Methyl-cytidine-5’-monophosphate

NMP-8311

184

2’-O-Methyl-guanosine-5’-monophosphate

NMP-8312

184

2’-O-Methyl-N,N’-dimethyl-adenosine

RP-3901163

2’-O-Methyl-N-benzyl-adenosine 5’-monophosphate

NMP-8313

184

2'-O-Methyl- β-L-uridine

RP-1909155

2'-O-Methyl-5-iodo-uridine

RP-1905155

2'-O-Methyl-5-methyl-cytidine

RP-1907155

2'-O-Methyl-5-propynyl-cytidine

RP-1548156

2'-O-Methyl-5-propynyl-uridine

RP-1856

156

2'-O-Methyl-adenosine

RP-1901155

2'-O-Methyl-adenosine-3’,5’-bis-monophosphate (sodium salt)

NDP-7311

187

2'-O-Methyl-adenosine-5’-triphosphate (sodium salt)

NTP-3386

188

2'-O-Methyl-ara-adenosine-5’-triphosphate

NTP-5311

190

2'-O-Methyl-ara-cytidine-5’-triphosphate

NTP-5312

190

2'-O-Methyl-ara-guanosine-5’-triphosphate

NTP-5313

190

2'-O-Methyl-ara-uridine-5’-triphosphate

NTP-5314

190

2'-O-Methyl-cytidine

RP-1902155

2'-O-Methyl-cytidine 5’-triphosphate (sodium salt)

NTP-3387

188

2'-O-Methyl-cytidine-3’,5’-bis(monophosphate) (sodium salt)

NDP-7312

187

2'-O-Methyl-guanosine

RP-1903155

2'-O-Methyl-guanosine-3’,5’-bis(monophosphate) (sodium salt)

NDP-7313

187

2'-O-Methyl-guanosine-5’-triphosphate (sodium salt)

NTP-3388

188

L

M

248

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INDEX-2: IUPAC Name, N-O-P
Product Name

Catalog#Page#

2'-O-Methyl-guanosine

RP-1903155

2'-O-Methyl-guanosine-3’,5’-bis(monophosphate) (sodium salt)

NDP-7313

187

2'-O-Methyl-guanosine-5’-triphosphate (sodium salt)

NTP-3388

188

2'-O-Methyl-inosine

RP-1906155

2'-O-Methyl-N,N’-dimethyl-adenosine

RP-3901163

2'-O-Methyl-ribothymidine

RP-1908155

2'-O-Methyl-ribouridine-5'-O-DMT-3'-CEP (repeated)

ANP-5754

95

2'-O-Methyl-uridine

RP-1904155

2'-O-Methyl-uridine-3’,5’-bis(monophosphate) (sodium salt)

NDP-7314

187

2'-O-Methyl-uridine-5’-triphosphate (sodium salt)

NTP-3389

188

3'-O-Methyl-5-methyl-cytidine

RP-2916156

3'-O-Methyl-adenosine

RP-2911156

3'-O-Methyl-cytidine

RP-2912156

3'-O-Methyl-guanosine

RP-2913156

3'-O-Methyl-guanosine-5’-monophosphate

NMP-8319

185

3'-O-Methyl-inosine

RP-2915156

3'-O-Methyl-uridine

RP-2914156

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF) (ABI Oligonucleotide Synthesizer

RN-1455

20

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), ABI 3900 Oligonucleotide Synthesizer

RN-1455

21

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), Expedite Oligonucleotide Synthesizer

RN-1455

23

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), MerMade Oligonucleotide Synthesizer

RN-1455

24

Oxidation Solution (0.02M Iodine/Pyridine/H2O/THF), PolyPlex Oligonucleotide Synthesizer

RN-1455

25

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF) (ABI Oligonucleotide Synthesizer

RN-1456

20

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), ABI 3900 Oligonucleotide Synthesizer

RN-145621

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), Expedite Oligonucleotide Synthesizer

RN-145623

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), MerMade Oligonucleotide Synthesizer

RN-145624

Oxidation Solution (0.1M Iodine/Pyridine/H2O/THF), PolyPlex Oligonucleotide Synthesizer

RN-145625

Oxidation Solution 1 (Iodine in Pyridine/H2O/THF)

RN-1210192'-O-Pivaloyloxymethyl-riboadenosine (N-PAC)-5'-O-DMTr-3'-CEP

ANP-3216

63

2'-O-Pivaloyloxymethyl-ribocytidine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-3217

63

2'-O-Pivaloyloxymethyl-riboguanosine (N-iPrPAC)-5'-O-DMTr-3'-CEP

ANP-3218

63

2'-O-Pivaloyloxymethyl-ribouridine-5'-O-DMTr-3'-CEP

ANP-3219

63

2'-O-Propargyl-1,1-dihydro-β-D-ribose-5'-O-DMT-3’-CEP; 2'-O-Propargyl-abasic-5'-O-DMTr-3’-CEP

ANP-9782

114

2'-O-Propargyl-abasic-5'-O-DMTr-3’-Icaa CPG

N-9784-05/10

114

2'-O-Propargyl-riboadenosine

RP-3401158

2'-O-Propargyl-riboadenosine (N-Bz)-5'-O-DMTr-3'-CEP

ANP-7751

112

2'-O-Propargyl-riboadenosine (N-Bz)-5'-O-DMTr-3'-Icaa CPG

N-8910-05/10

112

2'-O-Propargyl-ribocytidine

RP-3402

158

Mesitylene-sulphonyl-3-nitro-1,2,4-triazole (MSNT); 2,4,6-Trimethylphenyl; 3-nitro-1,2,4-triazol-1-yl-sulfone
Methoxy-N,N,N,N-tetraisopropylphosphane
Mix base phosphoramidites (equimolar) (dA+dC+dG+dT)
Monomethoxytrityl-chloride, (MMTr-Chloride)
O

P

249

Toll Free: (800) 762-9323
Toll Free: (800)762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, P
Product Name

Catalog#Page#

2'-O-Propargyl-ribocytidine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-7756

112

2'-O-Propargyl-ribocytidine (N-Ac)-5'-O-DMTr-3'-Icaa CPG

N-8960-05/10

112

2'-O-Propargyl-ribocytidine (N-Bz)-5'-O-DMTr-3'-CEP

ANP-7752

112

2'-O-Propargyl-ribocytidine (N-Bz)-5'-O-DMTr-3'-Icaa CPG

N-8920-05/10

112

2'-O-Propargyl-riboguanosine

RP-3403158

2'-O-Propargyl-riboguanosine (N-iBu)-5'-O-DMTr-3'-CEP

ANP-7753

112

2'-O-Propargyl-riboguanosine (N-iBu)-5'-O-DMTr-3'-Icaa CPG

N-8930-05/10

112

2'-O-Propargyl-riboinosine-5'-O-DMTr-3'-CEP

ANP-6191

112

2'-O-Propargyl-riboinosine-5'-O-DMTr-3'-Icaa CPG

N-8970-05/10

112

2'-O-Propargyl-ribouridine

RP-3404

158

2'-O-Propargyl-ribouridine-5'-O-DMTr-3'-CEP

ANP-7754

113

2'-O-Propargyl-ribouridine-5'-O-DMTr-3'-Icaa CPG

N-8940-05/10

113

3'-(H)-Phosphonate-2'-deoxyadenosine (N-Bz)-5'-O-DMTr TEA salt

ANP-3410

14

3'-(H)-Phosphonate-2'-deoxycytidine (N-Ac)-5'-O-DMTr TEA salt

ANP-3414

14

3'-(H)-Phosphonate-2'-deoxycytidine (N-Bz)-5'-O-DMTr TEA salt

ANP-3411

14

3'-(H)-Phosphonate-2'-deoxyguanosine (N-iBu)-5'-O-DMTr TEA salt

ANP-3412

143'-O-Propargyl-riboadenosine

RP-3301

158

3'-O-Propargyl-riboadenosine (N-Bz)-5'-O-DMTr-2'-CEP

ANP-9751

113

3'-O-Propargyl-riboadenosine (N-Bz)-5'-O-DMTr-2'-Icaa CPG

N-9881-05/10

113

3'-O-Propargyl-ribocytidine

RP-3302

158

3'-O-Propargyl-ribocytidine (N-Ac)-5'-O-DMTr-2'-CEP

ANP-9759

113

3'-O-Propargyl-ribocytidine (N-Ac)-5'-O-DMTr-2'-Icaa CPG

N-9889-05/10

113

3'-O-Propargyl-ribocytidine (N-Bz)-5'-O-DMTr-2'-CEP

ANP-9752

113

3'-O-Propargyl-ribocytidine (N-Bz)-5'-O-DMTr-2'-Icaa CPG

N-9882-05/10

113

3'-O-Propargyl-riboguanosine

RP-3303158

3'-O-Propargyl-riboguanosine (N-iBu)-5'-O-DMTr-2'-CEP

ANP-9753

113

3'-O-Propargyl-riboguanosine (N-iBu)-5'-O-DMTr-2'-Icaa CPG

N-9883-05/10

113

3'-O-Propargyl-ribouridine

RP-3304

158

3'-O-Propargyl-ribouridine-5'-O-DMTr-2'-CEP

ANP-9754

113

3'-O-Propargyl-ribouridine-5'-O-DMTr-2'-Icaa CPG

N-9884-05/10

113

3'-Phosphate-ON Icaa CPG

N-9977-05/10/20

118

5’-Phosphorylation (Bis-cyanoethyl-N,N-diisopropyl CEP)

CLP-1454

118

5-Phosphorylation (generates DMTr color); 5-Phosphate-ON Reagent

CLP-1544

118

5-Propargylamine-2',3'-dideoxycytidine-5’-triphosphate

NTP-5318

191

5-Propargylamine-2',3'-dideoxycytidine-5’-triphosphate disodium salt

NTP-5316

191

5-Propargylamine-2',3'-dideoxyuridine-5’-triphosphate disodium salt

NTP-5317

191

5-Propynyl-2'-deoxycytidine

DN-1541145

5-Propynyl-2'-deoxyuridine

DN-1846

145

5-Propynyl-2'-O-methyl-5'-O-DMTr-ribocytidine (N-Bz)

PM-1129173

5-Propynyl-2'-O-methyl-5'-O-DMTr-ribouridine

PM-1027173

5-Propynyl-2'-O-methyl-ribocytidine

RP-1548156

5-Propynyl-2'-O-methyl-ribouridine

RP-1856

156

5-Propynyl-5'-O-DMTr-deoxycytidine (N-Bz)

PM-1124

168

5-Propynyl-5'-O-DMTr-deoxyuridine

PM-1022168

5-Propynyl-5'-O-DMTr-ribocytidine (N-Bz)

PM-1126172

250

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INDEX-2: IUPAC Name, P-R
Product Name

Catalog#

Page#

5-Propynyl-5'-O-DMTr-ribouridine

PM-1024

172

5-Propynyl-ribocytidine

RP-1546152

5-Propynyl-ribouridine

RP-1842152

H-phosphonate activation reagent (Dipentafluorophenyl Carbonate)

RN-6464

19

N -Palmitoy-riboadenosine

RP-1041

152

6

Palmitoyl Polymeric Support

N-9821-03

125

Pentane diol; C5 Spacer

CLP-9901

126

Phenylacetyl-disulfide (PADS)

RN-1496

178

Polyethylenglycol 4500 CEP (Avg. M.W.~4500)

CLP-3119

125

Polystyrene non Cleavable Spacer

N-4545-03/10

16

Psoralen C18 Hexaethyloxyglycol CEP

CLP-6642

139

Psoralen C2 CEP

CLP-6647

138

Psoralen C4 CEP

CLP-6648

138

Psoralen C4 lcaa CPG

N-9081-05/10

139

Psoralen C6 CEP

CLP-6641

138

Psoralen CEP

CLP-6644

138

Psoralen Support

N-9375-05

139

Puromycin-2'-Succinyl Icaa CPG

N-1971-05/10

76

Riboadenosine

RP-1183

149

Riboadenosine (N-Bz)

PM-2101

161

Riboadenosine (N-Ethyl)RP-1035

163

Riboadenosine (N-isopentyl)

PM-6005

161

Riboadenosine (N-PAC)

PM-6001

161

Ribocytidine

RP-1184

149

Ribocytidine (N-Ac)

PM-2106

161

Ribocytidine (N-Bz)

PM-2102

161

Ribocytidine (N-iBu)

PM-2105

161

Ribocytidine (N-PAC)

PM-6002

161

Riboguanosine

RP-1185

149

Riboguanosine (N-iBu)

PM-2103

149

Riboguanosine (N-PAC)

PM-6003

161

Riboguanosine (N-phenyl acetyl)

PM-6004

161

Riboinosine

RP-1187

149

Ribothymidine; 5-Methyl-ribouridine

RP-1188

149

Ribothymidine-5’-monophosphate

NMP-8310

185

Ribouridine

RP-1186

149

Ribouridine-5’-diphosphate

NDP-7316

187

Ribouridine-5’-diphosphate disodium salt

NDP-7315

187

Ribouridine-rabinose

RP-2325

149

RNA Purification Kit

CSS-5232-02

91

RNA Purification Kit

CSS-5232-10

91

RNA Purification Kit

CSS-3268

91

RNA Purification Kit

CSS-5272

91

RNA Purification Kit

CSS-6634

91

RNA Purification Kit

CSS-5232

91

Rox Supports & Columns

N-2246-05

137

R

251

Toll Free: (800) 762-9323
33 Industrial Way, Wilmington, MA 01887 • T: (978) 694-4500 • F: (978) 694-4502

INDEX-2: IUPAC Name, S-T
Product Name

Catalog#Page#

3'-Spacer C4 CPG; Butyl CPG (for 3’-Butanol Spacer)

N-7178-05/10

129

C12 Spacer CE phosphoramidite; DMTr-Dodecane-diol Phosphoramidite

CLP-1114

124

C12 Spacer CE phosphoramidite; DMTr-Tetraethyloxy-glycol Phosphoramidite

CLP-1368

125

C18 Spacer CE phosphoramidite; DMTr-Hexa-ethyloxy-glycol Phosphoramidite

CLP-9765

125

C2 Spacer CE phosphoramidite; DMTr-Ethane-diol Phosphoramidite

CLP-2250

124

C3 Spacer CE phosphoramidite; DMTr-Propane-diol Phosphoramidite

CLP-9908

124

C4 Spacer CE phosphoramidite; DMTr-Butane-diol Phosphoramidite

CLP-9775

124

C4 Spacer polystyrene; DMTr-Butanol Polymeric Support

N-9168-05/10

124

C5 Spacer CE phosphoramidite; DMTr-pentane-Diol Phosphoramidite

CLP-9901

126

C6 Spacer CE phosphoramidite; DMTr-Hexane-Diol Phosphoramidite

CLP-1120

124

C9 Spacer CE phosphoramidite; DMTr-Nonane-Diol Phosporamidite

CLP-9009

124

C9 Spacer CE phosphoramidite; DMTr-Triethyloxy-Glycol Phosphoramidite

CLP-1113

125

Silanized Bottle (for Beaucage Reagent)

BL-1536

178

Silanized Bottles for Beaucage Reagent, ABI Oligonucleotide Synthesizer

BL-1536

20

Silanized Bottles for Beaucage Reagent, ABI 3900 Oligonucleotide Synthesizer

BL-1536

21

Silanized Bottles for Beaucage Reagent, Expedite Oligonucleotide Synthesizer

BL-1536

23

Silanized Bottles for Beaucage Reagent, MerMade Oligonucleotide Synthesizer

BL-1536

24

Silanized Bottles for Beaucage Reagent, PolyPlex Oligonucleotide Synthesizer

BL-1536

25

Spacer-DMT-Polyethyleneglycol 2000 CEP

CLP-2119

125

Spacer-DMT-Polyethyleneglycol 2000 CEP

CLP-3118

125

ssR-Me Amino linker

CLP-1131

120

ssR-H Amino linker

CLP-1132120

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), ABI Oligonucleotide
Synthesizer

RN-1535

20

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), ABI 3900
Oligonucleotide Synthesizer

RN-1535

21

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), Expedite
Oligonucleotide Synthesizer

RN-1535

23

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), MerMade
Oligonucleotide Synthesizer

RN-1535

24

Sulfurizing Reagent (Beaucage Reagent) for Introduction of Phosphorothioate (S-oligonucleotide), PolyPlex
Oligonucleotide Synthesizer

RN-1535

25

Symmetrical Branching CEP

CLP-5215

129

Symmetrical Branching Polymeric Support

N-7173-05

129

Symmetrical Branching Support lcaa CPG

N-5216-05/10

129

1,3,5-Tri –O-acetyl-2-deoxy-β-L-ribose

RN-1065

181

1,3,5-Tri–O-acetyl-2-deoxy-β-D-ribose

RN-1064181

1H-1,2,4-Triazole; 1,2,4-Triazole

RN-1412176

2,3,5-O-Tribenzoyl-β-D-ribofuranosyl-1-Acetate

RN-4131181

2'-O-Methyl-ribocytidine 5’-triphosphate disodium salt

NTP-3387

188

2'-O-TBDMS-5'-O-DMTr-riboadenosine (N,N-diBz)

PM-5857

174

2'-O-TBDMS-5'-O-DMT-riboadenosine (N-Bz)

PM-5851174

2'-O-TBDMS-5'-O-DMTr-riboadenosine (N-PAC)

PM-3501174

2'-O-TBDMS-5'-O-DMTr-ribocytidine (N-Ac)

PM-5856

174

2'-O-TBDMS-5'-O-DMTr-ribocytidine (N-Bz)

PM-5852

174

2'-O-TBDMS-5'-O-DMTr-ribocytidine (N-PAC)

PM-3502174

2'-O-TBDMS-5'-O-DMTr-riboguanosine (N-DMF)

PM-5859

174

2'-O-TBDMS-5'-O-DMTr-riboguanosine (N-iBu)

PM-5853

174

S

T

252

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INDEX-2: IUPAC Name, T
Product Name

Catalog#Page#

2'-O-TBDMS-5'-O-DMTr-riboguanosine (N-iPrPAC)

PM-3504174

2'-O-TBDMS-5'-O-DMTr-riboguanosine (N-PAC)

PM-3503174

2'-O-TBDMS-5'-O-DMTr-riboinosine

PM-5855

174

2'-O-TBDMS-5'-O-DMTr-ribouridine

PM-5854

174

2'-O-TBDMS-Isoribocytidine (N-DBF)-5'-O-DMTr-3'-CEP

ANP-7715

86

2'-O-TBDMS-Isoribocytidine (N-DBF)-5'-O-DMTr-3'-Icaa CPG

N-9712-05/10

86

2'-O-TBDMS-Pseudoribouridine-5'-O-DMTr-3'-CEP

ANP-8612

76

2'-O-TBDMS-Pseudoribouridine-5'-O-DMTr-3'-Icaa CPG

N-4617-05

76

2'-O-TBDMS-riboadenosine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-4546

57

2'-O-TBDMS-riboadenosine (N-Bz)-3'-O-DMTr-5'-CEP

ANP-3401

67

2'-O-TBDMS-riboadenosine (N-Bz)-3'-O-DMTr-5'-Icaa CPG

N-6201-05/10

67

2'-O-TBDMS-riboadenosine (N-Bz)-5'-O-DMTr-3'-CEP

ANP-5671

57

2'-O-TBDMS-riboadenosine (N-Bz)-5'-O-DMTr-3'-Icaa CPG

N-6101-05/10/20

58

2'-O-TBDMS-riboadenosine (N-Bz)-5'-O-DMTr-3'-succinyl Polystyrene

N-6211-03

64

2'-O-TBDMS-riboadenosine (N-Bz)-5'-O-MMTr-3'-CEP

ANP-5676

57

2'-O-TBDMS-riboadenosine (N-PAC)-5'-O-DMTr-3'-CEP

ANP-6671

59

2'-O-TBDMS-riboadenosine (N-PAC)-5'-O-DMTr-3'-Icaa CPG

N-P6101-05/10

60

2'-O-TBDMS-riboadenosine (N-PAC)-5'-O-MMTr-3'-CEP

ANP-6678

59

2'-O-TBDMS-riboadenosine (N-tBPAC)-5'-O-DMTr-3'-Icaa CPG

N-6207-05/10

60

2'-O-TBDMS-ribocytidine (N-Ac)-3'-O-DMTr-5'-CEP

ANP-3405

67

2'-O-TBDMS-ribocytidine (N-Ac)-3'-O-DMTr-5'-Icaa CPG

N-6206-05/10

67

2'-O-TBDMS-ribocytidine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-6676

57

2'-O-TBDMS-ribocytidine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-6676

59

2'-O-TBDMS-ribocytidine (N-Ac)-5'-O-DMTr-3'-Icaa CPG

N-6106-05/10/20

58

2'-O-TBDMS-ribocytidine (N-Ac)-5'-O-DMTr-3'-succinyl Polystyrene

N-6216-03

64

2'-O-TBDMS-ribocytidine (N-Bz)-3'-O-DMTr-5'-CEP

ANP-3402

67

2'-O-TBDMS-ribocytidine (N-Bz)-3'-O-DMTr-5'-Icaa CPG

N-6202-05/10

67

2'-O-TBDMS-ribocytidine (N-Bz)-5'-O-DMTr-3'-CEP

ANP-5672

57

2'-O-TBDMS-ribocytidine (N-Bz)-5'-O-DMTr-3'-Icaa CPG

N-6102-05/10/20

58

2'-O-TBDMS-ribocytidine (N-Bz)-5'-O-DMTr-3'-succinyl Polystyrene

N-6212-0364

2'-O-TBDMS-ribocytidine (N-Bz)-5'-O-MMTr-3'-CEP

ANP-5685

57

2'-O-TBDMS-ribocytidine (N-PAC)-5'-O-DMTr-3'-CEP

ANP-6672

59

2'-O-TBDMS-ribocytidine (N-PAC)-5'-O-DMTr-3'-Icaa CPG

N-P6102-05/10

60

2'-O-TBDMS-ribocytidine (N-tBPAC)-5'-O-MMTr-3'-CEP

ANP-6680

59

2'-O-TBDMS-riboguanosine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-4547

57

2'-O-TBDMS-riboguanosine (N-DMF)-5'-O-DMTr-3'-CEP

ANP-5678

57

2'-O-TBDMS-riboguanosine (N-iBu)-3'-O-DMTr-5'-CEP

ANP-3403

67

2'-O-TBDMS-riboguanosine (N-iBu)-3'-O-DMTr-5'-Icaa CPG

N-6203-05/10

67

2'-O-TBDMS-riboguanosine (N-iBu)-5'-O-DMTr-3'- succinyl Polystyrene

N-6213-03

64

2'-O-TBDMS-riboguanosine (N-iBu)-5'-O-DMTr-3'-CEP

ANP-5673

57

2'-O-TBDMS-riboguanosine (N-iBu)-5'-O-DMTr-3'-Icaa CPG

N-6103-05/10/20

58

2'-O-TBDMS-riboguanosine (N-iBu)-5'-O-MMTr-3'-CEP

ANP-5677

57

2'-O-TBDMS-riboguanosine (N-iprPAC)-3'-O-DMTr-5'-CEP

ANP-3406

67

2’-O-TBDMS-riboguanosine-(N-iprPAC) 5’-lcaa CPG

N-6209-05/10

67

2'-O-TBDMS-riboguanosine (N-iprPAC)-5'-O-DMTr-3'-CEP

ANP-6679

59

2'-O-TBDMS-riboguanosine (N-PAC)-5'-O-DMTr-3'-CEP

ANP-6673

59

2'-O-TBDMS-riboguanosine (N-PAC)-5'-O-DMTr-3'-Icaa CPG

N-P6103-05/10

60

253

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INDEX-2: IUPAC Name, T
Product Name

Catalog#Page#

2'-O-TBDMS-riboguanosine (N-PAC)-5'-O-MMTr-3'-CEP

ANP-6677

59

2'-O-TBDMS-riboguanosine (N-Phenyl-Ac)-5'-O-DMTr-3'-CEP

ANP-5679

59

2'-O-TBDMS-riboguanosine (N-tBPAC)-5'-O-DMTr-3'-Icaa CPG

N-6208-05/10

60

2'-O-TBDMS-riboinosine-5'-O-DMTr-3'-CEP

ANP-5680

74

2'-O-TBDMS-riboinosine-5'-O-DMTr-3'-Icaa CPG

N-8370-05/10

74

2'-O-TBDMS-ribopurine-riboside-5'-O-DMTr-3'-CEP; Nebularine CEP

ANP-8616

80

2'-O-TBDMS-ribopurine-riboside-5'-O-DMTr-3'-Icaa CPG; Nebularine CPG

N-9080-05/10

76

2'-O-TBDMS-ribopyridine-2-One-5'-O-DMTr-3'-CEP; Zebularine CEP

ANP-8611

76

2'-O-TBDMS-ribopyridine-2-One-5'-O-DMTr-3'-Icaa CPG; Zebularine CPG

N-9020-05/10

74

2'-O-TBDMS-ribothymidine-5'-O-DMTr-3'-CEP

ANP-7511

74

2'-O-TBDMS-ribothymidine-5'-O-DMTr-3'-Icaa CPG

N-8477-05/10

74

2'-O-TBDMS-ribouridine-3'-O-DMTr-5'-CEP

ANP-3404

67

2'-O-TBDMS-ribouridine-3'-O-DMTr-5'-Icaa CPG

N-6204-05/10

67

2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-CEP

ANP-5674

57

2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-Icaa CPG

N-6104-05/10/20

58

2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-Icaa CPG

N-P6104-05/10

60

2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-succinyl Polymeric Support

N-6214-03

64

2'-O-TBDMS-ribouridine-5'-O-MMTr-3'-CEP

ANP-5688

57

2'-O-TOM-riboadenosine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-3201

69

2'-O-TOM-riboadenosine (N-Ac)-5'-O-DMTr-3'-Icaa CPG

N-3201-05/10

69

2'-O-TOM-ribocytidine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-320269

2'-O-TOM-ribocytidine (N-Ac)-5'-O-DMTr-3'-Icaa CPG

N-3202-05/10

69

2'-O-TOM-riboguanosine (N-Ac)-5'-O-DMTr-3'-CEP

ANP-3203

69

2'-O-TOM-riboguanosine (N-Ac)-5'-O-DMTr-3'-Icaa CPG

N-3203-05/10

69

2'-O-TOM-ribouridine-5'-O-DMTr-3'-CEP

ANP-3204

69

2'-O-TOM-ribouridine-5'-O-DMTr-3'-Icaa CPG

N-3205-05/10

69

2'-O-Trifluoroacetamidopropyl-deoxycytidine (N-Bz)-5'-O-DMTr-3'-CEP

ANP-7116

31

2'-O-Trifluoroacetamidopropyl-deoxyuridine-5'-O-DMTr-3'-CEP

ANP-7115

31

2-Thio-2'-deoxyuridine-5'-O-DMTr-3'-CEP

ANP-9214

27

2-Thio-2'-deoxyuridine-5'-O-DMTr-3'-Icaa CPG

N-9510-05/10

27

2-Thio-thymidine-5'-O-DMTr-3'-CEP

ANP-9213

27

2-Thio-thymidine-5'-O-DMTr-3'-Icaa CPG

N-9509-05/10

27

2-Thio-2’-O-TBDMS-ribouridine-5'-O-DMTr-3'-CEP

ANP-9216

76

2'-Thymidine-3'-O-{P-(=O)(CNEt)}-(5'',3')-2''-deoxyadenosine (N-Bz)-5'-O-DMTr-3''-CEP Dimer

ANP-2513-CE

13

2'-Thymidine-3'-O-{P-(=O)(CNEt)}-(5'',3')-2''-deoxycytidine (N-Bz)-5'-O-DMTr-3''-CEP Dimer

ANP-2514-CE

13

2'-Thymidine-3'-O-{P-(=O)(CNEt)}-(5'',3')-2''-deoxyguanosine (N-Bz)-5'-O-DMTr-3''-CEP Dimer

ANP-2515-CE

13

2'-Thymidine-3'-O-{P-(=O)(CNEt)}-(5'',3')-2''-thymidine-5'-O-DMTr-3''-CEP Dimer

ANP-2516-CE

13

3'-(H)-Thymidine-5'-O-DMTr-3'-phosphonate TEA salt

ANP-3413

143'-O-TBDMS-5'-O-DMTr-riboadenosine (N-Bz)

PM-5861

175

3'-O-TBDMS-5'-O-DMTr-ribocytidine (N-Bz)

PM-5862

175

3'-O-TBDMS-5'-O-DMTr-riboguanosine (N-iBu)

PM-5863

175

3'-O-TBDMS-5'-O-DMTr-ribouridine

PM-5864

175

3'-O-TBDMS-5'-O-DMTr-Cytidine (N-Ac)

PM-5866

175

3'-O-TBDMS-riboadenosine (N-Bz)-5'-O-DMTr-2'-CEP

ANP-5681

72

3'-O-TBDMS-ribocytidine (N-Ac)-5'-O-DMTr-2'-CEP

ANP-5686

72

3'-O-TBDMS-ribocytidine (N-Bz)-5'-O-DMTr-2'-CEP

ANP-5682

72

3'-O-TBDMS-riboguanosine (N-iBu)-5'-O-DMTr-2'-CEP

ANP-5683

72

254

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INDEX-2: IUPAC Name, T
Product Name :Catalog#Page#

3'-O-TBDMS-riboinosine-5'-O-DMTr-2'-CEP

ANP-5687

72

3'-O-TBDMS-ribouridine-5'-O-DMTr-2'-CEP

ANP-5684

72

3'-Thiol-modifiers-C3-S-S CPG; 3’-Thiol Modifier C3 Disulfide lcaa CPG

N-9976-05/10

126

4-Thio (cyanoethyl)-2'-deoxyuridine-5'-O-DMTr-3'-CEP

ANP-7624

27

4-Thio (cyanoethyl)-thymidine-5'-O-DMTr-3'-CEP

ANP-6414

27

4-Thio-2'-deoxyuridine

DN-1263

145

4-Thio-2'-deoxyuridine-5'-O-DMTr-3'-Icaa CPG

N-9758-05/10

27

4-Thio-2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-CEP

ANP-810176

4'-Thio-ribouridine

RP-2304150

4-Thio-thymidine

DN-1781

145

4-Thio-thymidine-5'-O-DMTr-3'-Icaa CPG

N-9925-05/10

27

4-Triazolyl-2'-deoxyuridine-5'-O-DMTr-3'-CEP

ANP-9211

43

4-Triazolyl-2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-CEP

ANP-916776

4-Triazolyl-thymidine-5'-O-DMTr-3'-CEP

ANP-921243

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboadenosine

RP-8871

159

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboadenosine (N-Bz)

PM-1928162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboadenosine (N-iBu)

PM-1921162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboadenosine (N-PAC)

PM-1922162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-ribocytidine

RP-8872

159

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-ribocytidine (N-Ac)

PM-1923162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-ribocytidine (N-iBu)

PM-1924162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboguanosine

RP-8873

159

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboguanosine (N-Ac)

PM-1926

162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboguanosine (N-iBu)

PM-1927162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-riboguanosine (N-DMF)

PM-1925162

5',3'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-ribouridine

RP-8874

159

5’-Thiol-C3-S-S Modifier

CLP-8409

127

5'-Tetramethylrhodamine CEP; 5’-TAMRA CEP

CLP-9066

137

5'-Thiol (trityl)-modifier-C6 CEP; 5’-Thiol Modifier-Hexyl-6-CEP

CLP-5888

126

5'-Thiol (trityl)-modifier-C6 CPG; 3’-Thiol Modifier-S-Trityl lcaa CPG

N-9978-05/10

126

5'-Thiol (trityl)-modifier-dC (N-Ac) CEP; 5’-S-Trityl-2’ deoxy Cytidine CEP

CLP-8509

127

5'-Thiol-modifiers-C6 CEP; 1-Thiobenzoyl-hexanol-6 Cyanoethyl CEP

CLP-9773

127

6-Tetramethylrhodamine Supports & Columns; 6-TAMRA Supports & Columns

N-2255-05

137

6-Thio (cyanoethyl)-2'-deoxyguanosine (N-Ac)-5'-O-DMT-3'-CEP

ANP-7628

35

6-Thio-2'-deoxyguanosine

DN-1269

145

8-Thio-riboguanosine

RP-1190150

3

ANP-7441

73

3

N -Thiobenzoylethyl-2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-Icaa CPG

N-9828-05/10

73

N4-6-Tetramethylrhodamine-cytidine-3’- lcaa CPG; N4-6-TAMRA Cytidine-3’- lcaa CPG

N-2145-05

137

N -Thiobenzoylethyl-2'-O-TBDMS-ribouridine-5'-O-DMTr-3'-CEPTEG Cholesterol (Tetra Ethylene Glycol) CEP

CLP-2704131

TEG Cholesterol (Tetra Ethylene Glycol) Phosphonate
TEG Cholesterol (Tetra Ethylene Glycol) -H- Phosphonate TEA Salt

CLP-2705

131

Tetra-butyl-Ammonium-Fluoride (1M Sol in THF)

CSS-4356

91

Tetrachloro-fluorescein-Cyclohexyl CEP

CLP-1526

134

Tetrachloro-fluorescein-Phosphoramidite (TET),

CLP-9779

134

Thiol-modifier-C6-S-S CEP; 5’-Thiol C-6 Disulfide Modifier CEP

CLP-8506

126

255

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INDEX-2: IUPAC Name, T-U
Product Name

Catalog#

Page#

Thiol-modifier-C6-S-S CPG; DMTr-C6-Disulfide Solid Support

N-9987-05/10

126

Thiophenol/Triethylamine/Dioxane, ABI Oligonucleotide Synthesizer

RN-1465-AB30

20

Thiophenol/Triethylamine/Dioxane, ABI 3900 Oligonucleotide Synthesizer

RN-1465-AB39

21

Thiophenol/Triethylamine/Dioxane, Expedite Oligonucleotide Synthesizer

RN-1465-EX

23

Thiophenol/Triethylamine/Dioxane, MerMade Oligonucleotide Synthesizer

RN-1465-MR

24

Thiophenol/Triethylamine/Dioxane, PolyPlex Oligonucleotide Synthesizer

RN-1465-PX

25

Thymidine-5'-O-DMTr-3'-CEP

ANP-5554

5

Thymidine Monohydrate

DN-1004

140

Thymidine-3'-O-DMTr-5'-CEP

ANP-4674

10

Thymidine-3'-O-DMTr-5'-Icaa CPG

N-3354-05/10

10

Thymidine-5'-O-DMTr-3'-CEP

ANP-5554

3

Thymidine-5'-O-DMTr-3'-CEP

ANP-5554

7

Thymidine-5'-O-DMTr-3'-Icaa CPG

N-5104-05/10/20

4

Thymidine-5'-O-DMTr-3'-Icaa CPG

N-P5104-05/10/20

6

Thymidine-5'-O-DMTr-3'-Non-clevable long chain spacer

N-7524-15/60/10-60

16

Thymidine-5'-O-MMTr-3'-CEP

ANP-5561

3(+)-a-Tocopherol-Phosphoramidite

CLP-2706

130

TOM-C-6 CEP

CLP-8508

125

Traps (DNA moisture traps), Extra Large

DMT-1972

51

Traps (DNA moisture traps), Large

DMT-1973

51

Traps (DNA moisture traps), Medium

DMT-1974

51

Traps (DNA moisture traps), Small

DMT-1975

51

Trimethoxytrityl-Chloride, (TMT-Chloride)RN-1491

177

UnyLinker Icaa CPG

N-4000-05/10/20

17

UnyLinker Microarray Slides (Discontinued )N-4501

17

UnyLinker Polystyrene Support

N-4000-03

17

U

256

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