The 13th Annual Meeting of JSIT
September 14-15, 2006, Kurashiki, Japan
Keynote Lecture
Pathophysiologicaldevelopment andimmunotoxicology: what wehave found from research
related to silica and silicate
such as asbestos

Takemi Otsuki

Department of Hygiene, Kawasaki
Medical School

Lee S. Newman

University of Colorado at Denver

Jean F. Regal (1),Amy L. Greene(1), Ronald R
Regal (2), Mark(1) Biochemistry & Molecular
Biology, University of Minnesota
Medical School, Duluth, MN, USA,
(2) Mathematics & Statistics,

Khalil Hayssam

Department of Immunology,
Charles River Laboratories

Special Lecture 1Immunotoxicology of
Berylium lung disease

and Health Services Center, USA

Special Lecture 2
Models and mechanisms ofchemical respiratory allergy:
Not all allergens are equal

Rutherford (3)University of Minnesota, Duluth,
MN, USA, (3) Veterinary &Biomedical Sciences, University of
Minnesota, St. Paul, MN, USA

Special Lecture 3
Interaction between
therapeutics and theimmune system: Casestudies

Preclinical Services, Montreal,
CanadaInvited Lecture 1
Inflammation andenvironmental factors

Hiroyuki Takano

Environmental Health Sciences
Division, National Institute forEnvironmental Studies, Tsukuba,Japan

Kou Sakabe

Department of Public Health andMolecular Toxicology, Kitasato
University School of
Pharmaceutical Sciences,Environmental Medical Center,
The Kitasato Institute, Tokyo,
Japan

Invited Lecture 2
Sick house syndrome
research 2006

Symposium:
Fibrous and nanomaterials
and immunotoxicologicalresearch

Organizer

Seishiro Hirano

Environmental Health Sciences
Division, National Institute forEnvironmental Studies, Tsukuba,
Japan

Factors in hazard evaluationof fibrous materials

Yasumitsu

Department of Hygiene, Kawasaki

Nishimura

Medical School, Kurashiki, Japan

Yasuo Morimoto

Department of Occupational
Pneumology, Institute ofIndustrial Ecological Science,
University of Occupational andEnvironmental Health,Kitakyushu, Japan

Functional alteration ofYasumitsu(1) Department of Hygiene,

natural killer Cells exposed to Nishimura (1),

Kawasaki Medical School,asbestos for a long period

Yoshie Miura (2),Megumi Maeda

Kurashiki, Japan, (2)Eppley
Institute for Cancer Research,(1), Hiroaki
Hayashi (1),Takemi Otsuki (1)University of Nebraska MedicalCenter, Omaha, USA

Transport of nanoparticles
through aleveolo-capillarybarrier

Akiko Furuyama,
Sanae Kanno,
Seishiro Hirano

Research Center for
Environmental Risk, National
Institute for Environmental
Studies, Tsukuba, Japan

Nanoparticles as drugdelivery system: Issues andperspectives

Masahiro
Murakami

Faculty of Pharmacy, Osaka
Ohtani University, Tondabayashi,
Japan

WorkshopA guideline toimmunotoxicity studies ofhuman pharmaceutics

Organizer

Jun-ichi Sawada

Division of Biochemistry andImmunochemistry, The National
Institute of Health Science, Tokyo,Japan

Naohisa Tsutsui

Toxicology Laboratories,
Pharmaceuticals Research
Department, Mistubishi Pharma
Corporation, Chiba, Japan

ICH (International
Conference on
Harmonisation of TechnicalRequirements forRegistration of
Pharmaceuticals for HumanUse) S8 Immunotoxicity
guideline

Jun-ichi Sawada

Division of Biochemistry andImmunochemistry, The NationalInstitute of Health Science, Tokyo,Japan

Pathology of lymph nodes
and Peyer's patches

Toshio Imai (1),Jiro Sonoda (2),Hiroshi Maeda (3),Shigeru Hisada (1)(1) Division of Pathology, National
Institute of Health Science, Tokyo,Japan, (2) Drug Safety ResearchLaboratories, Eisai Co., Ltd.,
Ibaragi, Japan, (3) Drug Safety
Research Laboratories, Shin
Nippon Biomedical Laboratories
Co., Ltd., Tokyo, Japan, (4) Safety
Research Department, ASKA

Pharmaceutical Co., Ltd.,
Kanagawa, Japan
Interpretation of stress-Shigeru Hisadarelated changes

Safety Research Department,ASKA Pharmaceutical Co., Ltd.,
Kawasaki, JapanThe Immunotoxicology inter- Andre H Penninks

TNO Quality of Life Productlaboratory project (IILP):
The Validation of a T cell-Manager, Experimental
Immunology, AJ Zeist, The

dependent antibodyNetherlands), gave his lecture inresponse (TDAR) using

the name of the IILP group ofkeyhole limpet hemocyanin

investigators(KLH) in rats
Q & A format lecture about

Osamu Fueki

Office of New Drug I,

the "Explanation of ICH S8Pharmaceuticals and Medical

guideline

Devices Agency, Tokyo, Japan
Naohisa Tsutsui

Toxicology Laboratories,
Pharmaceuticals Research
Department, Mistubishi Pharma
Corporation, Chiba, Japan

General Oral Presentation
Comparison of the ELISA
versus PFC assay for
detection of T cell dependent
antibody response in 6 strainrats

Ryota Kawai,
edicinal Safety Research
Tetsuo Aida,
Laboratories, Sankyo Co., Ltd.,
Motoko Ajioka,
Japan
Masae Yagi,
Satomi Komatsu,
Tsutomu Kimura,
Tadashi Furukawa,Sunao Manabe

Relationship between IL-6
and anti-oxidant proteinsproduced in rats, i.p. treatedwith carbon tetrachloride

Yosuke Ochiai,
Department of Hygienic
Kenich Onishi,
Chemistry, Showa Pharmaceutical
Kenzaburo Yamadi, University, Tokyo, JapanToshiyuki
Chikuma, Hiroshi
Hojo

Relation of chemicalstructure and induction

Kenichi Tomiyama, Department of Food andAkiko Yamaguchi, Nutritional Sciences, University ofactivity of apoptosis in an
organotin's sight

Yurie Sayama,
takao Kuriyama,

Shizuoka, Shizuoka, Japan

Yasuaki Arakawa
The differences between

Masashi Tsunoda(1) Department of Preventive

types of murine astrocyte
cell lines for the toxic effects(1), Takayuki
Haino (2), Kyoko

Medicine and Public Health,
Kitasato University School ofof dobutyl, octyl acid andpoly-L-lactides

Ito (1), Yoko Inoue Medicine, Sagamihara, Japan, (2)(1), Takeo Miki (1), Department of Obsterics andYuichiro Kudo (1),Toshihiko Satoh(1), Yoshiharu

Gynecology, Jikei University
School of Medicine, Tokyo, Japan,(3) Division of Medical Devices,

Aizawa (1), Toshie National Institute of Health
Tsuchiya (3)Sciences, Tokyo, Japan
Methoxychlor induces thymic Tomoki Fukuyama, Laboratory of Immunotoxicology
apoptosis in vivo in mice

Yukari Tajima,
Koichi Hayashi,and Acute Toxicology, Toxicology
Division, The Institute ofAtsuko Haishima,
Hideaki Fujie,

Environmental Toxicology, Ibaragi,JapanTsutomu,Matsumoto, Yutaka
Hayashi, Hideo
Ueda, Yasufumi
Shutoh, Tadashi
Kosaka, Takanori
HaradaAnalysis on Immune reaction Keiko Nohjara (1),in T-cell specific
Kana Ao (1),(1) Environmental Health
Scieneces Division, National

constotutively-active AhR
mutant transgenic mice toYoshimi Miyamoto(1), Tomohiro Ito

Institute for Environmental
Studies, Tsukuba, Japan, (2)clarify the role of activated
AhR in T cells(1), Kaoru Inouye(1), Xiaoqing Pan(1), Hozumi

TARA Center, University ofTsukuba, (3) CDBIM, University ofTokyo

Motohashi (2),MasayukiYamamoto (2),Chiharu Tohyama(3)
Screening of the novel antiallergic peptide in milk
proteinTakeaki Okamoto,
Sayuri Ono,
YohsukeDepartment of Biochemistry,
Kawasaki Medical School,Okayama, Japan

Minatogawa
Effects of antithyroids on the Ryosuke Nakamura (1) Div. Biochem. Immunochem.,
debeloping immune system(1), Reiko Teshima (2) Div. Pathol., Natl. Inst. Healthof the rat(1), Akiko
Sci., Tokyo, Japan
Hachisuga (1),
Kayoko Takagi (1),Gye-Hyeong Woo(2), Makoto
Shibutani (2), JunIchi Sawada (1)Effects of NSAIDs

Kiyoshi Kushima,

Drug Safety Researchadministered during lategestation on thedevelopment of immune

Keiko Oda, Shozo
Sakuma, Michio
Fujiwara

Laboratories, Astellas Pharma,Osaka, Japan

In vitro screening for druginduced anaphylactoid

Takako Hamano,
Taizou Tomari,

Toxicology Laboratory,
Pharmaceutics Research Division,

reaction

Saori Okada,
Naohisa Tsutsui

Mitsubishi Pharma Corporation,Japan

Murine food allergy modelwith oral sensitization andTomoko Shindo(1), Yukiko(1) Hatano Research Institute,
Food and Drug Safety Center,oral challenge (5)Kanazawa (1),Mami Furuya (1),Kanagawa, Japan, (2) National
Instoitute of Health Science,system in rat pups

Yoshiyuki Tazuru
Tokyo, Japan(1), Kohichi Kojima(1), Reiko Teshima(2)
Suppression of IL-1-induced
MCP-1 release byKunihiro Akimaru,
Ryoji Hirota,

environmetal chemicals

Takeshi Nakamura, Kochi, Nankoku, Japan
Da-Chuan Zhang,
Hiroyuki Nakamura

Environmental Medicine, Kochi
Medical School, University ofAnalysis of pathological

Megumi Maeda(1) Department of Hygiene,

related gene expression on
lymphocytes from patientswith asbestos-induced(1), Yoshie Miura(1), Yasumitsu
Nishimura (1),Kawasaki Medical School,
Kurashiki, Japan, (2) Departmentof Respiratory Medicine, Hyogo

disxeases

Hiroaki Hayashi
College of Medicien, Nishinomiya,(1), Maolong Dong Hyogo, Japan, (3) Okayama Rosai(1), Ayuko Uesaka Hospital, Okayama, Japan(2), Kozo
Kuribayashi (2),Takashi Nakano(2), Takumi
Kishimoto (3),Takemi Otsuki (1)Regulation of dendritic cell

Kazutakefunctions by neuropeptide
CGRO via RAMP1/CL

Tsujikawa, Tomomi Graduate School ofShigeno, Yusuke
Pharmaceutical Science, Osaka

Department of Immunology,

receptors

Ohgitani, Emi
Hirayama, So-University, Osaka, Japan

Ichiro Fukuda,
Hiroshi Yamamoto
Immunocharacterization ofarsenite-induced human

Teruaki Sakurai,
Seiichiro Himeno

macrophages (As-Mp)

Laboratory of Molecular Nutrition
and Toxicology, Faculty of
Pharmaceutical Scieneces,
Tokushima Bunri University,
Tokushima, Japan

Inhibitory activities of

Yoko Tanaka (1),squamous cell carcinoma
antigens on extrinsic

Sachiko Kanaji (1), Biochemistry, Department of
Yasuhisa Sakata
Biomolecular Sciences, Saga

(1) Division of Medical

cysteine proteases(1), Kiyonari
Masumoto (1),Medical School, Saga, Japan, (2)Instotute for the Biotechnology ofKohei Takeshita(1), Kazuhiko

Infectious Diseases, University ofTechnology Sydney, Australia, (3)Arima (1), John P.
Dalton (2), JamesH. McKerrow (3),Sandler Center, UCSF, San
Francisco, CA, USA, (4) Division ofInfection and Immunology,

Graham H.
Instotute of Biomedical and Life
Coombs (4), Kenzi Sciences, Wellcome Centre for
Izuhara (1)Molecular Parasitology, Glasgow
Biomedical Research Centre,
University of Glasgow, UK

General Poster Presentation
Anti-KHL IgG antibody

Koichi Hayashi,

The Instotute of Environmental

response in rat for
immunotoxocity evaluation

Tadashi Kosaka,Toxicology, Ibaragi, Japan
Tomoki Fukuyama,
Yukari Tajima,
Hideo Ueda,
Takanori Harada

Evaluation of skinsensitizing

Hideo Ueda,

potential on chromatedcooper arsenate (CCA) used

Tomoki Fukuyama, of Environmental Toxicology,
Koichi Hayashi,
Ibaragi, Japanas a wood preservative

Yukari Tajima,
Hideaki Fujie,
Yutaka Hayashi,
Atuko Haishima,
Yasufumi Shutoh,

Toxicology Division, The InstotuteTadashi Kosaka,
Takanori Harada
Changes in gene expression
in the lungs of paraquatintoxicated mouse model

Masafumi Tomita(1), Hironobu
Katsuyama (2),(1) Department of Medical
Toxicology, (2) Department ofPublic Health, (3) Department ofYasumitsu
Nishimura (3),Hygiene, (4) Department ofBiochemistry, Kawasaki MedicalYoshie Miura (3),
Yoko Watanabe

School, Kurashiki, Japan(4), Kazuo Hidaka(4), Takemi Otsuki(1)
Analysis of dioxin-regulated
genes in DN thymocytes

Tomohiko Ito,
Keiko Noharausing microarray

Environmental Health Sciences
Division, National Institute forEnvironmental Studies, Tsukuba,Japan

Effect of DBDE on the

Reiko Teshima (1), (1) Division of Biochemistry andimmune system in theRyosuke Nakamura Immunochemistry, (2) Division ofdeveloping postnatal rats(1), Rika
Nakamura (1),Pathology, National Institute of
Health Science, Tokyo, Japan

Akiko Hachisuka(1), Jun-Ichi
Sawada (1),Makoto Shibutani(2)
Effects of dexamethasone on Motoyuki Kawai,maternal and offspring
Masafumi Nagata,

Developmental researchLaboratories, Shionogi & Co., Ltd.,

immune system exposed

Misa Yamai,Osaka, Japan

during gestational or
lactation period in rats

Masahiro
Hirashiba, Susumu
Kanamori, Atsuko
Hishikawa,Kazuichi Nakamura

Evaluation of sensitization

Akihiko Hisatomi,

Drug Safety Researchpotential of drugs using
secondary popliteal lymph

Kiyoshi Kushima,
Shozo Sakuma,

Laboratories, Astellas PharmaInc., Osaka, Japannode assay

Michio Fujiwara

Effect ofbutylhydroxytokuene on

Kouya Yamaki,
Shin Yoshino

allergic reactions

Department of Pharmacology,
Kobe Pharmaceutical University,
Kobe, Japan

Suppressive effects on

Nobuhiro Nishio(1) Department of Public Health,hypersensitivity by dietary(1), Katsuyasu

Wakayama Medical University,

restriction in isocyanate

Kouda (2), Hirao

Wakayama, Japan, (2)sensitized miceKouno (3),Hiroyasu Ishihara

Department of Public Health, Kinki
University, Osaka, Japan, (3)(3), Harunobu

Department of Hygiene, Kansai

Nakamura (4),Medical University, Osaka, Japan,

Tastuya Takeshita(1)(4) Development Science, Kobe
University, Hyogo, Japan

17beta-estradiol enhamces
IL-18 expression in mouse

Fumitoshi
Faculty of Pharmaceutical
Sakazaki, Masahiro Sciences, Setsunan University,

contact hypersensitivity

Fujiyama, Hitoshi
Ueno, KatsuhikoNakamura

HIrakata, Osaka, Japan

Investigation of analytical

Daisuke Mukai,

Biosafety Research Center, Foods,

method for lymphocyte

Maki Shibata, Maki Drugs and Pesticides, Shizuoka,

subset in rat blood andorgan samples

Makita, Eiji MakiJapanThe Colormetric assay by cell Seiji Shibata,counting kit-8 for rat
Mitsui Isobe,

Safety Research Department,
ASAKA Pharmaceutical Co., Ltd.,

peripheral blood and splenic

Kawasaki, Japan

Shigeru Hisada

lymphocyte blastgenesis
Analysis of regulatory T cells Hiroaki Hayashi(1) Department of Hygiene, (4)in silicosis patients(1), Yoshie Miura

Department of Publiuc Health, (5)(1), Fuminori
Hyodoh (2),Department of Medical Toxicology,
Kawasaki Medical School,

Yasumitsu

Kurashiki, Japan, (2) Department

Nishimura (19<of Nursing, Kawasaki College ofMegumi Maeda
Allied Health Professions,(1), Maolong Dong Kurashiki, Japan, (3) Department(1), Masayasu

of Internal Medicine, Kuraka

Kusaka (3),Hironobu

Hospital, Bizen, Japan

Katsuyama (4),Masafumi Tomita(5), Takemi Otsuki(1)
Luncheon seminar 1
Immunotoxicology

Lawrence Jacobassessment

Molecular Biology andImmunology, Central Laboratory,
Charles River Laboratories
Preclinical Services, Edinburgh,
Scotland, UK

Luncheon seminar 2
In vitro and in vivo
prediction of monoclonal
antibody cytokine release
syndrome in man

Mark Wing

Huntington Life Science Ltd., UK