The 7th Annual Meeting of JSIT
2000.9.25-26.
Chiba University Keyaki Kaikan（Chiba）
President: Shiro UEDA (Faculty of Pharmaceutical Sciences, Chiba University)
Special Lecture <1>
Developmental
immunotoxicity induced by

Steven D. Holladay

dioxins

Anatomy andToxicology,College of
Veterinary Medicine, Virginia
Polytechnic InstituteSpecial Lecture <2>
Induction of Allergic Diseases
and Fc receptor

T. Saito

Department of moleculargenetics, Graduate school ofmedicine,Chiba University

Workshop
Immunotoxicology Working
Group, Preclinical Evalution
Subcommittee, Drug

Collaborative study toestablish immunotoxicology
evaluation procedures forpharmaceuticals

Kazuichi Nakamura

Evaluation Committee, Japan
Pharmaceutical Manufacturers
Association; Developmental
Research Laboratories,
Shionogi & Co., Ltd.

Collaborative study toestablish immunotoxicology

T. Morita(1)，H.
Irie(2)，T.
Kimura(3)，M.

(1)Toyama Chemical Co.，
(2)Welfide Co.，(3)Toa EiyoLtd.，(4)Fuji Biomedix Co.，

Collaborative study toestablish immunotoxicology
evaluation procedures forpharmaceuticals using
indomethacin

Y. Kuninishi(1)，S.
Hisada(2)，S.
Ozawa(3)，K.
Hoshino(4)，J.
Nishimura(5)(1)Kyorin PharmaceuticalCo.，Ltd.，(2)TeikokuHormone Mfg. Co., Ltd.，(3)Kissei Pharmaceutical Co.,
Ltd.，(4)Yamanouchi
Pharmaceutical Co., Ltd.，(5)Kowa Company, Ltd.

Collaborative study toestablish immunotoxicology
evaluation procedures forpharmaceuticals using dl propranolol hydrochloride

N. Sato(1)，T.
Narita(2)，K.
Mochizuki(3)，T.
Kimura(4)，K.
Suwa(5)，H.
Izumi(6)，M.
Nagata(7)(1)Asahi Chemical Industry
Co., Ltd.，(2)Ajinomoto Co.,
Inc.，(3)Kaken
Pharmaceutical Co., Ltd.，(4)Sankyo Co., Ltd.，(5)Bozo
Research Center Inc., (6)Shin
Nippon Biomedical
Laboratories Ltd.，(7)Shionogi & Co., Ltd.

Collaborative study toestablish immunotoxicology
evaluation procedures for

K. Tanaka(1)，M.
Kokubu(2)，M.
Yano(3)，Y.

(1)Kyowa Hakko Kogyo Co.,
Ltd.，(2)PanapharmLaboratories Co., Ltd. ，evaluation procedures forpharmaceuticals using
promethazine hydrochloride

Sakaguchi(4)，H.
Doi(5)，H.
Hattori(6)，D.
Mukai(7)(5)Takeda Chemical
Industries，(6)Daiichi
Pharmaceutical Co.，
(7)Biosafety Research Centerpharmaceuticals using 5-

Tagawa(4)，H.

(3)Environmental BiologicalfluorouracilKato(5)Life Science Research Center
Inc. (BILIS)，(4)Sanwa
Kagaku Kenkyusho Co., Ltd.，(5)Sumitomo Chemical Co.,Ltd.
(1)Shin Nippon Biomedical

Collaborative study to

Y. Takahashi(1)，T.

establish immunotoxicology

Aoki(2)，Y. Mera(3)，evaluation procedures forpharmaceuticals using

K. Yagi(4)，M.
Chino(5)，H.

nortriptyline hydrochloride

Hattori(6)Laboratories, Ltd.，(2)EisaiCo., Ltd.，(3)Zeria
Pharmaceutical Co., Ltd.，(4)Taisho Pharmaceutical Co.,
Ltd.，(5)Ina Research Inc.，(6)Daiichi Pharmaceutical Co.,Ltd.
(1)Fujisawa Pharmaceutical

Collaborative study toestablish immunotoxicology
evaluation procedures forpharmaceuticals using
haloperidol

A. Hisatomi(1)，M.
Nagata(2)，H.
Atai(3)，J.
Kawahara(4)，N.
Wada(5)，S.
Hisada(6)Collaborative study toestablish immunotoxicology
evaluation procedures forpharmaceuticals using
diphenylhydantoin

Tadashi Kosaka(1)，Kenji Naohara(2)，Shuji Ishizuka(3)，YumikoTsujimura(4)，D.
Mukai(5)(1)Institute of environmental
toxicology，(2)Dainippon
Pharmaceutical Co.，(3)SSPCo.，(4)Pfizer PharmaceuticalInc.，(5)Biosafety ResearchCenterImmunotoxicity due to
medicine and chemical
substances in clinical cases Dermatology filed -E. Tanabe

Department of Dermatology,
Sakura Hospital, Toho
University School of Medicine

Immunotoxicity due tomedicine and chemical
substances - Respiroatory
Diseases -Hiroshi Kimura

Department of ChestMedicine, Chiba University
School of Medicine

Liver dysfunction caused byvarious drugs

O. Yokosuka

Department of Medicine,
Chiba University School ofMedicine

Co., Ltd.，(2)Shionogi & Co.,
Ltd.，(3)Mitsubishi Chemical
Safety Institute Ltd.，(4)Kirin
Brewery Co., Ltd.，(5)Aventis
Pharma Ltd.，(6)Teikoku
Hormone Mfg. Co., Ltd.

Symposium

Adverse effects of drugs onT. Iseki
blood cells and hematopoiesis

Division of Molecular Therapy,Advanced Clinical ResearchCenter, The Institute ofMedical Science, The
University of Tokyo

S. Ueda(1)，M.
Drug induced nephropathies - Ogawa(2)，Y.
Clinical casesMakino(2)，S.
Hasegawa(2)(1)Dept of Drug Information
and Communication，Graduate School of
Pharmaceutical Sciences,
Chiba University, (2)The First
Dept. of Internal Medicine,
School of Medicine, Chiba
University

General Presentation

T. Shindo(1)，Y.
Kanazawa(1)，M.
Analysis of immunological

Furuya(1)，K.

biomarkers from toluene

Kojima(1)，R.

diisocyanate-sensitized miceI

Teshima(2)，H.

humoral immunity

Okunuki(2)，J.

responses(productivity ofantibodies)

Sawada(2)，K.
Takahashi(3)，M.
Ohsawa(3)，T.
Yoshida(4）M. Ohsawa(1)，F.

Analysis of immunologicalbiomarkers in toluene
diisocyanate-sensitized mice.
(2) Composition and functionof T lymphocytes

Otsuka(1)，T.
Yoshida(2)，T.
Kinoue(3)，T.
Shindo(4)，Y.
Kanazawa(4)，K.
Kojima(4)，J.
Sawada(5)(1)Hatano Research Institute,
Food and Drug Safety
Center，(2)Department ofBiochemistry andImmunochemistry, National
Institute of Health Sciences，(3)Faculty of PharmaceuticalSciences, Teikyo University，(4)Asahikawa Medical College(1)Faculty of PharmaceuticalSciences, Teikyo University，(2)Asahikawa Medial College，(3)School of Medicine, TokaiUniversity，(4)Food and Drug
Safety Center，(5)NationalInstitute of Health

T. Kimura(2)，T.
Aida(2)，K.
Nagami(1)，K.
Application of the mouse
Watanabe(1)，K.
popliteal lymph node assay toTanaka(1)，H.
immunotoxicologicalIrie(1)，M.
evaluation of drugs
Yokota(1)，A.
Suda(1)，K.
Nakamura(1)(1)Immunotoxicology
Working Group, Preclinical
Evaluation Subcommittee,
Drug Evaluation Committee,
Japan Pharmaceutical
Manufacturers Association;(2)Sankyo Co., Ltd.

Lymphocyte subset analysis in T. Aida，K.
popliteal lymph node assay
Muramatsu，M.
(PLNA)
Ajioka，T. Kimura

Medical Safety ResearchLaboratories, Sankyo Co., Ltd.

Flow cytometric analysis of
bromodeoxyuridine
incorporated cells in themurine local lymph nodeassay

Local lymph node assay with
non-radioactive alternative
endpoints

Toxicology Laboratory,
N. Tsutsui，S.
Yokohama Research Center,
Mochiduki，J. Soejima Mitsubishi-Tokyo
Pharmaceuticals, Inc.
Masahiro
Yamashita(1)，Akiko(1)Immunotoxicology

Suda(2)，Mitsuyuki
Tabei(1)，Hans-Working Group, Preclinical
Evaluation Subcommittee,

Werner Vohr(1)，Drug Evaluation Committee,
Naohisa Tsutsui(1)，Japan Pharmaceutical
Ritsuyoshi Suzuki(1)， Manufacturers Association;
Katsuaki Kikuchi(1)，Kouki Mochizuki(1)，(2)Taisho Pharmaceutical Co.,LTD.

Kazuichi Nakamura(1)Evaluation of immunedisrupters' effects on fetal
thymus proliferation andJ. Soejima，I.
Hosokawa，S.

differentiation in fetal thymusorgan culture system

Mochiduki，N. Tsutsui

Reproductive immunotoxicity

N. Naukura，Y.

of the endocrine disruptors on Shinozaki，A.
rat
Hasegawa，T.

Toxicology Laboratory,
Yokohama Research Center,
Mitsubishi-Tokyo
Pharmaceuticals, Inc.
Department of Molecular
Pharmacology andPharmacothrepeutics.

Nakamura，S. Yano， Graduate School ofK. UenoPharmaceutical Sciences,
Chiba Univerisity
Immunotoxicological effects
of endocrine disrupting
chemicals on mouse

F. Sakazaki，K.
Division of Environmental
Ueda，F. Kurashima， Health, Faculty oflymphocytes blastformationand the involvement of theD. Shiota，H. Ueno，
K. Nakamuro

Pharmaceutical Sciences,
Setsunan University

T. Otsuki(1)，H.
Sakaguchi(1)，M.

(1)Dept. Hyg., & (2)Radiat.

estrogen receptor
Apoptotic cell death induced
by an asbestos, chrysotile B:
Analysis using humanUno(2)，Y.
Matsuo(3)，A.
lymphoid cell lines and trial toTomokuni(1)，F.
establish chrysotile BHyodoh(1)，Y.
resistant subline
Isozaki(1)，A. Ueki(1)H. Suzuki(1)，Y.
Ohtani(1)，M.
Murayama(1)，C.

Cell death suppression factors
Ono(1)，C.
in tolerance manifestation of
Yamaguchi(1)，Y.
organotin-induced thymus
Arakawa(1)，T.
atrophy
Takeuchi(2)，Y.
Nakano(2)，H.
Nakashima(3)Y. Kanazawa(1)，H.

Oncol., Kawasaki Med. Sch.,
Kurashiki, (3)Fujisaki CellCenter, Hayashibara Biochem.
Lab., Okayama(1)Dept. of Hygiene &Preventive Medicine, Facultyof Health Sciences, The
University of Shizuoka，(2)Research Reactor
Institute, Kyoto University，(3)Ohsaka Prefectural
Institute of Public Health(1)Hatano Research Institute,
Food and Drug Safety
Center，(2)Division of

Immunotoxicological effects
Yoshino(2)，T.
of environmental chemicals I.Shindo(1)，M.
Fly ash extracts from
Environmental Engineering,
Furuya(1)，R.
municipal waste incineratorKanagawa Environmental
Ohta(1)，K. Kojima(1)Research Center
H. Asai，N. Sato，S.
M. Chen，T.

Immunosuppressive effect ofKawanabe，M.
aristolochic acid Ⅰ,Ⅱin inbred
Manabe，S.
miceYamagata，M.

Drug Information andCommunication, Faculty of
Pharmaceutical Sciences,Chiba University

Mochizuki，S. Ueda
Does not the secretory IgAagainst Japanese Cedar Pollen S. Tsujita，K.

Dept. of Social andEnvironmental Medicine,

be induced during Pollen
Season in spring?

Osaka University Graduate
School of Medicine

Morimoto

Evaluation of allergenic

K. Kojima(1)，Y.

(1)Hatano Research Institute,
Food and Drug Safety

components in buckwheat
and its products. Antigenicity

Kanazawa(1)，T.
Shindo(1)，Y.

Center，(2)Final ProductDevelopment Division,

tests in guinea pigs and ELISA Iijima(2)Predisposition and preceding
factors of "occupational
allergy in doctors" in medical
students

K. Sato，Y. Kusaka

Sakuma Confectionery Co.,Ltd.
Dept. of Environmental
Health, School of Medicine,
Fukui Medical University

Effect of TCDD on immune

H. Fujimaki，K.

National Institute forresponse in NC/Nga mice

NoharaEnvironmental Studies

Protective effects of Ro 408757 on immunotoxicities

T. Inoue，I. Horii

Dept. of Preclinical Science,
Nippon Roche Researchinduced by cyclophosphamide
Modulating effects ofindomethacin andpentoxifylline on TNF
productionCenter
Safety Research Department,
Mamoru Inoue，Kohki
Central ResearchMochizuki，Junichi
Laboratories, Kaken
YoshidaPharmaceutical Co., Ltd.

Study on iodine allergy 1.
Specificity of antigen
recognition of anti-iodine
antibody and generation ofiodinated protein frominorganic and organic iodine
containing chemicals

H. Shionoya，Y.
Sugihara，K. Okano， Eisai Tsukuba Research
F. Sagami，K.
Laboratories, Eisai Co., Ltd.
Mikami，K. Katayama

Study on iodine allergy 2.
Characteristics of adverse
reactions to contrast media in
Y. Sugihara，H.
relation to iodinated self
Shionoya，K. Okano， Eisai Tsukuba Researchprotein antigen hypothesisF. Sagami，T.
Laboratories, Eisai Co., Ltd.
and development of a skin
Mikami，K. Katayama
diagnostic agent of iodine
allergy devoid of sensitizing
antigenicity