Program
September 12 (Monday)
Main hall（1614）
8:45 ～ 8:50 Opening Remark
The 29th Annual Meeting of the Japanese Society of Immunotoxicology
President: Hiroyuki Kojima
The 79th Meeting of Allergy and Immunotoxicology study group of Japan Society for Occupational Health
Cordinator: Takahiko Yoshida

8:50 ～ 10:15 Students and Young Scientists Session ＜OY-01 ～ OY-10＞
Chairperson:

Michiyo Kubo

（Chugai Pharmaceutical Co., Ltd.）Rie Yanagisawa （National Institute for Environmental Studies）、
OY-01 Bisphenol A induces allergic airway inflammation through the activation of ocular immune
systems〇Tatsuo Ueda1,3), Takumi Adachi1), Eiko Koike2), Rie Yanagisawa2), Kenzo Tsuzuki3), Etsushi Kuroda1)
1)

Department of Immunology, School of Medicine, Hyogo Medical University, 2) Health andEnvironmental Risk Division, National Institute for Environmental Studies, 3) Department ofOtorhinolaryngology-Head and Neck Surgery, School of Medicine, Hyogo Medical University

OY-02 Induction of antigen-specific immune responses by interleukin-33 as a mucosal adjuvant〇Amane Mukai1), Koubun Yasuda1), Shiori Egashira1), Takumi Adachi1), Kazufumi Matsushita1),
Etsushi Kuroda1)
1)

Department o Immunology, Shool of Medicine, Hyogo Medical University

OY-03 Effects of particulate matters on the expression and function of COVID-19-related proteins〇Issei Omori1), Raga Ishikawa1), Akiko Honda1, 2) , Tomoya Sagawa2, 3), Hirohisa Takano1, 2)

1)Grad Sch of Eng, Kyoto Univ, 2)Grad Sch of Global Environ Studies, Kyoto Univ, 3)Inflammation and

Immunology, Grad Sch of Med Sci, Kyoto Pref Univ of Med

OY-04 Activation of type I Interferon signaling in dendritic cells and T cells of the mouse model of
COPA syndrome〇Takashi Kato 1), Ryota Yamasaki 1), Naoko Wakaki-Nishiyama 1), Izumi Sasaki 1), Shiori Kaji 2),
Kohei Murakami 3), Hiroaki Hemmi 3), Yoshitaka Honda 4,5,6), Kazushi Izawa 6), Yoshiro Otsuki 7),
Tadashi Matsubayashi 8), Ryuta Nishikomori 9), Tsuneyasu Kaisho 1)
1)

Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, 2)Second

Department of Internal Medicine, Wakayama Medical University, 3)Laboratory of Immunology, Facultyof Veterinary Medicine, Okayama University of Science, 4) Institute for the Advanced Study of Human
Biology (ASHBi), Kyoto University, 5)Department of Immunology, Kyoto University Graduate Schoolof Medicine. 6) Department of Pediatrics, Kyoto University Graduate School of Medicine, 7) Departmentof Pathology, Seirei Hamamatsu General Hospital, 8)Department of Pediatrics, Seirei Hamamatsu
General Hospital, 9)Department of Pediatrics and Child Health, Kurume University School of Medicine

OY-05 Immunological characterization of tissue resident macrophages by using genetically modified
mouse〇Shiori Kaji1), Izumi Sasaki2), Takashi Kato2), Naoko Nishiyama2), Asumi Yamamoto2), Kazuki
Wakimura2), Masayuki Kitano1), Tsuneyasu Kaisho2)
1)

Second Department of Internal Medicine, Wakayama Medical University, 2) Department of

Immunology, Institute of Advanced Medicine, Wakayama Medical University

OY-06 Prediction of the safety and efficacy of STING ligands administration in the nonhuman primate
model〇Shokichi Takahama 1), Kazuya Ishige 2), Takuto Nogimori 1), Yasuhiro Yasutomi 3), Victor Appay 1,4),

Takuya Yamamoto 1,4, 5, 6)
1)

Laboratory of Immunosenescence, Center for Vaccine and Adjuvant Research, National Institutes ofBiomedical Innovation, Health and Nutrition, Osaka, Japan, 2) Biochemicals Division, Yamasa
Corporation, Chiba, Japan, 3) Laboratory of Immunoregulation and Vaccine Research, Tsukuba Primate
Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, 4)
Université de Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux,France, 5) Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences,
Osaka University, Osaka, Japan, 6) Department of Virology and Immunology, Graduate School of
Medicine, Osaka University, Osaka, Japan

OY-07 Low-dose oral exposure to Citrinin significantly exacerbates the pathophysiology of psoriasis ina mouse model via activating type 2 conventional dendritic cell
〇Hiroki Yamaguchi1), Naoki Iwashita1,2), Yoshiichi Takagi1,3), Masayo Kushiro4), Tomoki Fukuyama1)
1)

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 2) Bioalch,

3)

Japan SLC, Inc., 4) Institute of Food Research, National Agriculture and Food Research Organization

OY-08 Subchronic oral exposure to Fumonisin B2 aggravates the cutaneous inflammation in a mousemodel of atopic dermatitis via inhibiting ceramide synthesis〇Mana Ando1), Hiroki Yamaguchi 1), Ai Morimoto 1), Naoki Iwashita 2), Yoshiichi Takagi 3), Tomoya
Yoshinari 4), Tomoki Fukuyama 1)
1)

Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 2) Bioalch,

3)

Japan SLC, Inc., 4) National Institute of Health Sciences

OY-09 Macrophage responses to single-walled carbon nanotubes and multi-walled carbon nanotubes〇Shin-Ichiro Yamaguchi1), Qilin Xie2), Miki Kuroiwa1), Kota Kasahara2), Masafumi Nakayama1)
1)Grad. Sch. Pharm. Sci., Ritsumeikan Univ., 2)Grad. Life Sci., Ritsumeikan Univ.

OY-10 Tim4 recognizes carbon particles〇Miki Kuroiwa1), Shin-Ichiro Yamaguchi1), Yoshinobu Kato1), Hisaya Akiba2), Masafumi Nakayama1)
1)Pharm Sci, Ritsumeikan Univ, 2)Juntendo Univ Sch Med

10:30 ～ 11:00 Oral Presentation ① ＜ON-01, ON-02＞
Chairperson: Izumi Sasaki （Wakayama Medical University）
ON-01 Ni-binding protein CXCL4 and vitamin D3 analogue augment sublingual immunotherapy for
Ni allergy〇Toshinobu Kuroishi1), Kanan Bando1, 2), Shunji Sugawara1)
1)

Division of Oral Immunology, 2)Division of Orthodontics and Dentofacial Orthopedics, Tohoku

University Graduate School of DentistryON-02 ATP can regulate inflammatory neutrophil endocytosis〇Duo Wang1), Zirui Zeng2), Ryuji Okazaki1), Yasuhiro Yoshida3)
1)

Department of Radiobiology and Hygiene Management, Institute of Industrial Ecological Sciences,

University of Occupational and Environmental Health, Japan, 2)First Department of Internal Medicine,
School of Medicine, University of Occupational & Environmental Health, Kitakyushu, Japan,
3)

Department of Immunology and Parasitology, School of Medicine, University of Occupational andEnvironmental Health, Japan

11:10 ～ 11:55 Educational Lecture １ ＜EL-01＞
Chairperson: Hiroyuki Kojima (Health Sciences University of Hokkaido)
EL-01

How far can cancer be prevented?

〇Masahiro Asaka
President, Health Sciences University of Hokkaido

11:55 ～ 13:00 ＜Lunch time＞

Main hall（1614）
13:00 ～ 13:35 General Assembly
13:40 ～ 16:10

Symposium: “Environment, Immunity and Disease” ＜S-01 ～ S-06＞

Chairperson: Masashi Tachibana （Graduate School of Pharmaceutical Sciences, Osaka University）
Shigeki Aoki （Graduate School of Pharmaceutical Sciences, Chiba University）
S-01

Multigenerational effects and epigenetic modification changes by gestational inorganic arsenic
exposure〇Takehiro Suzuki1), Kazuyuki Okamura1), Keiko Nohara1)
1)

S-02

Health and Environmental Risk Division, National Institute for Environmental Studies

Understanding and controlling environmental particle-induced inflammatory diseases〇Naoki Takemura
Graduate School of Pharmaceutical Sciences, Osaka University

S-03

Suppressive mechanisms on autoimmune diseases by helminth infection〇Chikako Shimokawa
Department of Parasitology, National Institute of Infectious Diseases (NIID)

S-04

Anaphylaxis to immune checkpoint inhibitors exacerbated by cancer pathology: analysis of amouse model〇Hiroto Hatakeyama
Graduate School of Pharmaceutical Sciences, Chiba University

S-05

Off-target cytotoxicity of antibody-drug conjugates〇Michihiko Aoyama1), Minoru Tada1), Akiko Ishii-Watabe 1)
1)

National Institute of Health Sciences

S-06

Involvement of Fc receptors in the immunotoxicity of biopharmaceuticals〇Shunsuke Ito1), Chiyomi Kubo1)
1)

Translational Research Division, Chugai Pharmaceutical Co., Ltd.

16:20 ～ 17:10 Special Lecture １ ＜SL-1＞
Chairperson: Tin-Tin Win-Shwe （National Institute for Environmental Studies）
SL-1

Protecting public health from per- and polyfluoroalkyl substances: Focus on Immunotoxicity〇Jamie C. DeWitt
Professor, Pharmacology and Toxicology, Brody School of Medicine, East Carolina University

Poster & Company Exhibition Hall (1606), Young Poster Hall (1605)
17:10 ～ 18:10 Poster Discussion Session ＜PN-01 ～ PN-19、PY-01 ～ PY-03＞(Posters for Students and Young Scientists Session (OY-01～OY-10) are also included in this session)

PN-01 Effects of in vitro exposure to bisphenols on activation of dendritic cells induced by IL-33〇Eiko Koike1), Rie Yanagisawa1), Tin-Tin Win-Shwe1)
1)

Health and Environmental Risk Division, National Institute for Environmental Studies

PN-02 Effects of bisphenol S exposure on neuroinflammation and cognitive impairment throughdysregulation of autophagy and synaptic plasticity in allergic asthmatic mice〇Tin-Tin Win-Shwe1), Rie Yanagisawa1), Eiko Koike1)
1)

Health and Environmental Risk Division, National Institute for Environmental Studies, Japan

PN-03 The effect of Diphenylarsinic acid (DPAA) on respiratory allergic responses using mice model〇Risako Tajiki1), Hitoshi Tajima1), Yuko Watanabe1), Tadashi Kosaka1),
1)

The Institute of Environmental Toxicology

PN-04 Respiratory sensitizer detection method using respiratory allergy mice model with intratracheal
challenge〇Hitoshi Tajima1), Risako Tajiki-Nishino1), Yuko Watanabe1), Tadashi Kosaka1)
1)

The Institute of Environmental Toxicology

PN-05 Establishing a new evaluation test for respiratory allergy caused by proteins〇Yi-Ting Lai1), Asuka Katagiri 1), Takuo Yuki 1), Masaaki Miyazawa 1)
1)

Safety Science Research Laboratories, Kao Corporation, Tochigi, Japan

PN-06 Altered respiratory and immune systems and their association with the gut microbiota in
SAMP8 mice〇Rie Yanagisawa1), Eiko Koike1), Takehiro Suzuki1), Kazuyuki Okamura1), Tin-Tin Win-Shwe1)
1)

Health and Environmental Risk Division, National Institute for Environmental Studies

PN-07 Relationship between profile of cytokine production by peripheral blood NK and T cells andefficacy in the treatment of Nivolumab in patients with malignant mesothelioma〇Yasumitsu Nishimura1), Suni Lee1), Naoko Kumagai-Takei1), Tatsuo Ito1), Nobukazu Fujimoto2),
Toshiyuki Kozuki3), Takemi Otsuki1,4)
1)

Dept of Hygiene, Kawasaki Medical School, 2)Dept of Medical Oncology, Okayama Rosai Hospital,

3)

Dept of Thoracic Oncology and Medicine, Shikoku Cancer Center, 4)Shinjo-son National Health

Insurance Clinic

PN-08 Development of highly-sensitive allergy test using chimeric IgE receptor-expressing cultured
mast cells
Haruyo Akiyama1), Chisato Kurisaka1), Satoshi Tadokoro2), Kenichi Kumasaka2),〇Ryosuke
Nakamura3)

1)

Teikyo Heisei Univ, 2)Kanagawa Pref Inst Pub Health, 3)Natl Inst Health Sci

PN-09 Study on the activation of THP-1 cells by mixed exposure of silicon dioxide nanomaterial withskin sensitizer or febrile substance〇Takao Ashikaga1), Akiko Ohno1), Rion Arai2), Kazutoshi Iijima3)
1)

National Institute of Health Sciences, 2)College of Engineering Science, Yokohama National

University, 3 )Yokohama National University

PN-10 A human skin explant test as a novel in vitro assay for the detection of adverse immune
reactions to aggregated monoclonal antibodies.
〇Anne Mary Dickinson1,2), Ana Martins-Ribeiro1,2), Arathi Kizhedath3), Shaheda Sameena Ahmed1),
Jarka Glassey3)
1)

Alcyomics Ltd, The Biosphere, Draymans Way, Newcastle Helix, Newcastle Upon Tyne, NE4 5BX,

UK, 2 ) Translational and Clinical Research Institute Faculty of Medical Sciences, Newcastle University,
Newcastle-upon-Tyne, NE2 4HH, UK, 3 ) Chemical Engineering and Advanced Materials, Newcastle
University, Newcastle-upon-Tyne NE17RU, UK

PN-11 Development of an in vitro innervated skin model for the detection of adverse neuropathic
events〇Anne Dickinson1), Matthew Freer1), Shaheda Ahmed1)
1)

Alcyomics Ltd, The Biosphere, Draymans way, Newcastle upon Tyne

PN-12 TARC/CCL17 is associated with CD8+ T cell recruitment in abacavir-induced skin toxicity in
HLA-B*57:01-transgenic mice
〇Shigeki Aoki1), Yuying Gao1), Saki Kuwahara1), Akira Kazaoka1), Kousei Ito1)
1)

Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University

PN-13 Development of a method for genotyping a surrogate marker of HLA-B*58:01 forallopurinol-induced SJS/TEN〇Eri Tsukagoshi1), Ryosuke Nakamura1), Hideo Asada2), Yoshiro Saito1)
1)

National Institute of Health Sciences, 2)Nara Medical University

PN-14 Intracellular metabolism change affects the susceptibility to HLA-related idiosyncratic drug
toxicity〇Takeshi Susukida1), Shigeki Aoki 2), Yoshihiro Hayakawa1)
1)

Institute of Natural Medicine, Univ of Toyama, 2 )Lab of Biopharm, Grad School of Pharm Sci, Chiba

Univ

PN-15 Effect of Gosha-Jinki-Gan on Levels of Specific mRNA Transcripts in Mouse Testes after
Busulfan Treatment〇Ning Qu1,2), Kenta Nagahori2), Miyuki Kuramasu2), Yuki Ogawa2), Daisuke Kiyoshima1), Hayato
Terayama1), Kaori Suyama1), Shogo Hayashi1), Masahiro Itoh2)
1)

Department of Anatomy, Tokai University School of Medicine, Japan2)

Department of Anatomy, Tokyo Medical University, Japan

PN-16 Effects of dexmedetomidine on the localization of α2A-Adrenergic and imidazoline receptor inmouse testis〇Hayato Nomura1), Hayato Terayama2), Daisuke Kiyoshima2), Ning Qu2), Kosuke Shirose1), Kou
Sakabe3), Takeshi Suzuki1)
1)

Department of Anesthesiology, 2)Department of Anatomy, Tokai University School of Medicine,

3)

Center for Preventive Medical Sciences, Chiba University

PN-17 Establishment of an assay to evaluate innate immune reaction response to oligonucleotide drugs
using human whole blood〇Shogo Matsumura1), Kiyoshi Kushima1), Ko Omura1)

1)

Exploratory Pathophysiology, Non-Clinical Biomedical Science, Applied Research & Operations,Astellas Pharma Inc.

PN-18

Recommendation for clinical sample collection used for immunogenicity evaluation during

development of biopharmaceuticals〇Akiko Ishii-Watabe1), Hiroko Shibata1), Kazuko Nishimura1), Yoshiro Saito2)
1)

Division of Biological Chemistry and Biologicals, 2Division of Medicinal Safety Science, National

Institute of Health Sciences

PN-19 Immune-cell activation by BiTE antibody aggregates〇Minoru Tada1), Michihiko Aoyama1), Akiko Ishii-Watabe1)1)National Institute of Health Sciences

PY-01 Development of transfer and replacement of alveolar macrophages for functional analysis ofalveolar macrophages.
〇Inoue Hinata1), Takumi Adachi1), Etsushi Kuroda1)
1)

Department of Immunology, Hyogo Medical University

PY-02 The effect of iron oxide particles on respiratory cells〇Yuya Higaki1), Raga Ishikawa1), Akiko Honda1,2), Megumi Nagao2), Takamichi Ichinose2), Hirohisa
Takano1,2)1)Grad. Sch. of Eng., Kyoto Univ., 2)Grad. Sch. of Global Environ. Studies, Kyoto Univ.

PY-03 Analysis of immune-related molecules in pancreatic cancer chemoprevention by fucoxanthin〇Wataru Murase1), Masaru Terasaki1,2), Atsuhito Kubota1), Ayaka Yasuda1), Hiroyuki Kojima1,2)
1)

Pharm Sci, and 2)Adv Res Prom Ctr, Health Sci Univ Hokkaido

18:15 ～ 19:30 Award Ceremony for Students and Young Scientists
Get-together Meeting

September 13 (Tuesday)
Main hall（1614）
9:00 ～ 9:45

Oral Presentation ② ＜ON-03 ～ ON-05＞

Chairperson: Masafumi Nakayama （College of Pharmaceutical Sciences, Ritsumeikan University）
ON-03 Analysis of a novel mucosal adjuvant utilizing programed cell death〇Takumi Adachi1), Etsushi Kuroda1)
1)

Department of Immunology, Hyogo Medical University

ON-04 Role of extracellular vesicles in pulmonary inflammation and allergic exacerbation ofparticulate matters〇Raga Ishikawa1), Yuta Shimohata1), Ryota Tamadai1), Akiko Honda1,2), Kaori Sadakane3), Yoshikazu
Mikami4), Takamichi Ichinose2), Hirohisa Takano1,2)1)Grad Sch of Eng, Kyoto Univ, 2)Grad Sch of Global Environ Studies, Kyoto Univ, 3)Dept of Health Sci,

Oita Univ of Nursing and Health Sci, 4)Grad Sch of Med and Dent Sci, Niigata Univ

ON-05 Evaluation of specific IgM antibody production and blood retention by administration of weak
low pH-responsive peptide-modified liposomes〇Hideyuki Masuda1), Tomomi Ohida1), Tomoko Satoh1), Satoshi Mrimoto1), Susumu Hama1)
1)Pharm. Sci., Musashino Univ.

9:55 ～ 10:45 Special Lecture 2 ＜SL-2＞
Chairperson: Kouichi Yoshinari （School of Pharmaceutical Sciences, University of Shizuoka）
SL-2

Indigo treatment targeting the mucosal healing of ulcerative colitis; Yin and yang
〇Takanori Kanai
Professor, Div. Gastroenterology and Hepatology, Dept. Internal Medicine, Keio University School of
Medicine & AMED-CREST (multi-sensing project), Tokyo, Japan

10:45 ～ 12:00 Awardee Presentation ＜AL-01 ～ AL-03＞
Chairperson: Tsuyoshi Nakanishi (Gifu Pharmaceutical University)
JSIT Award Lecture
AL-01

Involvement of immunological dysregulations in arsenic-induced diseases〇Seiichiro Himeno1, 2)
1)

Sch Pharmacy, Showa Univ, 2) Fac Pharm Sci Tokushima Bunri Univ

JSIT Young Investigator Award Lecture
AL-02

Preclinical immunotoxicity and immunogenicity studies aimed at improving safety predictionsof biopharmaceuticals〇Chiyomi Kubo
Translational Research Division, Chugai Pharmaceutical Co., Ltd.

AL-03

Study on immunotoxicity through mRNA stability control mechanism〇Ryuta Muromoto
Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University

12:00 ～ 13:00 ＜Lunch time＞

13:00 ～ 13:30

Oral Presentation ③ ＜ON-06, ON-07＞

Chairperson: Tomoki Fukuyama (School of Veterinary Medicine, Azabu University)
ON-06 Bacterial translocation due to lowered intestinal immunity in zinc deficiency〇Takamasa Kido1), Anna Nakamura1), Hiroyuki Yanagisawa1), Machi Suka1)
1)

The Jikei University School of Medicine

ON-07 Mechanistic study of anti-inflammatory effects in the Elemental Diet: Focus on its component,
tryptophan.
〇Atsuhito Kubota1), Ryoichi Aoyagi1), Ruka Ito1), Masaru Terasaki1,2), Hiroyuki Kojima1,2)
1)

Pharm Sci, Health Sci Univ Hokkaido, 2) Adv Res Prom Center, Health Sci Univ Hokkaido

13:40 ～ 14:25

Educational Lecture 2 ＜EL-02＞

Chairperson: Yasuo Yoshioka (Research Institute for Microbial Diseases, Osaka University)
EL-02

Understanding efficacy, effectiveness and safety of vaccines: from an epidemiologicalperspective〇Wakaba Fukushima
Professor, Department of Public Health, Osaka Metropolitan University Graduate School of Medicine

14:30 ～

16:30

Workshop: “Challenges in Immunotoxicity Assessment Emerging from theDiversification of Drug Molecular Modes” ＜WS-01 ～ WS-05＞

Chairperson: Tetsuo Aida （Daiichi Sankyo Co., Ltd.）
Kiyoshi Kushima （Astellas Pharma Inc.）
WS-01

Recent In Vivo Immunotoxicology studies Using Cynomolgus Moneys at SNBL

〇Yoshihiro Takahashi
Shin Nippon Biomedical Laboratories, Ltd.

WS-02

Issues and considerations for evaluation of therapeutic antibodies using cytokine release assay〇Tetsuo Aida
Medicinal Safety Research Laboratories, Daiichi Sankyo Co., Ltd.

WS-03

Considerations in immunotoxicity assessment of biopharmaceuticals〇Chiyomi Kubo
Translational Research Division, Chugai Pharmaceutical Co., Ltd

WS-04

Challenges in immunotoxicity evaluation for nucleic acid drugs and gene therapy products〇Shogo Matsumura1), Kiyoshi Kushima1), Ko Omura1)
1)

Exploratory Pathophysiology, Non-Clinical Biomedical Science, Applied Research & Operations,Astellas Pharma Inc.

WS-05

Comprehensive Discussion

16:30 ～ 16:45 Award Ceremony for the Best Presenter of 29th Annual Meeting
Closing Remarks