Corporate Profile

Namiki Shoji Co., Ltd.:A trading company involved in marketing pharmaceuticals, compounds for
drug discovery, intermediates, and health foods; and providing various
biological evaluation services of compounds.
Continues to be chosen as a strategic partner by numerous clients,
including major Japanese pharmaceutical companies.

Launched in 1974 as a company trading in raw materials of generic pharmaceuticals.
We later started importing and marketing drug-discovery compounds (compounds for new drugdevelopment), first time in Japan. We continue to supply high-quality drug-discovery compoundsand intermediates required at the cutting edge of new drug development, and we are holding a firm
position with a top share in this field.
With the support of our Pharmaceutical Dept., Drug Discovery Chemicals Dept., and BiologicalResearch Dept., we constantly strive to supply products and services giving our clients 100% satisfaction.
We hope, by means of these commercial activities, to play a significant role in radical new drug development,
and our satisfaction lies in any contribution to human health.

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Corporate Profile

Greetings from the President"By mutually beneficial commercial
activities, we grow together with ourclients"

Tatsuya Namiki
Company President

With our philosophy of "By mutually beneficial commercial activities, we grow together with our clients",
at Namiki Shoji our aim is to expand our business energetically, in our role as the strategic partner ofpharmaceutical companies.
Since the founding of Namiki Shoji, we have constantly striven to develop radical new products andservices to satisfy our clients, in a creative manner, rising to all challenges presented.
Our business now has two pillars: Pharmaceuticals, and compounds for drug discovery.
Screening compounds and various types of building blocks, which are indispensable for drug design andnew drug discovery, are marketed by our Drug Discovery Chemicals Dept. Our highly trained andexperienced personnel carry out thorough data management of compounds, using a unique and highquality chemical database containing millions of structures collected worldwide; deliver ordered compounds
rapidly; and then provide complete aftercare in response to all the client's requirements.
Our Pharmaceutical Dept., on the other hand, markets Japanese and overseas pharmaceutical raw materials,
intermediates and formulations with complete reliability, on the basis of many years' experience.
In addition, in 2007 we established our new Biological Research Dept., in order to meet the increasing
variety of demands from our clients, and compound evaluation services were initiated in that department.
Furthermore, in order to achieve a strategic position in the enormous mainland-Asian market, which is ofincreasing importance for the global pharmaceutical industry, we established a wholly owned subsidiary,
Shanghai Five Ace Trading Co., Ltd., in 2009.
Namiki Shoji will in future continue to strive to fulfill all our clients' requirements and expectations as ahighly reliable company and we hope for the continued support of all relevant parties.

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Sal
esDepartmentCorporate ProfileCompany History
DateEvents

Details and purposes

1974

Established as a pharmaceutical raw material trading company inShinjuku Matsui Building by Toru Namiki as the President

Established in expectation of increasing specialization in pharmaceutical industry
and more use of generics

1977

Collaboration with several Japanese raw material manufacturers

Consistent supply of high-quality, Japanese-made raw materials for generics, withentirely new style of collaboration between manufacturers and the trading company

1980

Exclusive contract with Sterochim Co. (Italy)

Importation of steroids as raw materials for generic formulation development
started.

1984

General agency contract with Maybridge Chemical Co., Ltd. (UK)First involvement with screening compounds

1985

Started business of screening compounds

Forseeing new era of drug discovery, chemical libraries and high-throughput
screening.

1986

General agency contract with Farmabios S.p.A. (Italy)

Expansion of steroid importation and marketing- Fall of The Berlin Wall - new trends in compound business from ex-Communist countries
1989

1992

Started business of combinatorial chemistry reagents

Preparation for the second stage of drug discovery

Full office automation achieved

Preparation for Internet Age: One PC per each Namiki Shoji employee

New Product Research Department established

To strengthen drug discovery support side of businessOsaka branch established, at Doshomachi, Chuo-ku, Osaka

To provide good service to clients in western Japan

General agency contract with Peakdale Molecular Ltd. (UK)

Dealing with out-sourcing and contract synthesis

1993

General agency contract with SPECS and BioSPECS B.V. (Netherlands) Contract with suppliers worldwide to further increase diversity of compounds

1996

Remodeling the head office

In-house environment reorganized to improve customer services

1999

Party held celebrating Namiki Shoji's 25th year of business

Gratitude to all relevant parties

2002

1st Drug Discovery Seminar held

To provide a space for information exchange among pharmaceutical companies

Website launched

Easy and convenient access to Namiki Shoji

Weighing Room opened

Weighing service started. Finely-tuned services, such as filling to customer vials
and barcode control, put into operation.

2003

Distribution of Drug Discovery News started

Initiation of e-mail information service for clients2004

2nd Drug Discovery Seminar held

First time to hold seminar at two locations (Tokyo and Osaka)

Party held celebrating Namiki Shoji's 30th year of businessWishing to grow further, together with clients and suppliers

General agency contract with Enamine Ltd. (Ukraine)

Expanded targeted libraries and virtual compound libraries

2005

General agency contract with AnalytiCon Discovery GmbH (Germany) Establishment of library of natural products that cannot be synthesized chemically
Location of Osaka Branch changed

Move to present location at Fushimimachi, Chuo-ku, Osaka

Tatsuya Namiki becomes President

General reshuffle of Board of Directors including President

Establishment of New Product Planning Department

To explore new business opportunities in life-science field

Location of Tokyo HQ changed

Move to the new place to increase administrative efficiency

3rd Drug Discover Seminar held

In collaboration with Peakdale Molecular

ChemCupid establishedA free, online chemical database

General agency contract with CEREP Co. (France)

To deal with increasingly diverse requirements at drug discovery stage

Biological Research Department established

Compound evaluation services started in this department

4th Drug Discover Seminar held

Held in collaboration with Enamine Ltd.

Shanghai Branch established

Entry to the rapidly growing Chinese market

2009

Shanghai Five Ace Trading Co., Ltd. started the operation

For worldwide supply of reliable Chinese raw materials and intermediates

2010

Establishment of Reagent Business Department

To start selling stock compouds across the world

5th Drug Discover Seminar held

Held in collaboration with Enamine Ltd.

Awarded the Grand Prize as the Excellent Company for Management
by Shinjuku City.

The management with continuous challenges and innovative power was evaluated.

2006

2007

2008

2011

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Corporate Profile

Details of Services"Providing services that are useful for our corporate partners"

Dept.

Drug Discovery
Chemicals Dept.

Dept.

PharmaceuticalDept.

ServiceDetails

Screening
compounds

The speeding up of new drug development has necessitated provision of numerous
compounds. Namiki Shoji can provide approximately 4.5 million compounds fromworldwide suppliers. We also provide up-to-date chemical information from everywhere in
the world, and strive to be of the maximum help to our clients.

Building blocks

Building blocks are raw materials for making screening compounds, and are also usefulin combinatorial chemistry, synthesis of new compounds, etc. We provide building blocks
with specific characteristics, including ones that are not commercially available in Japan.
Making use of our global network of contacts, we can deliver such items cheaply andquickly.

Referencestandard

We investigate and provide with compounds that are used for reference and comparison
with candidates of new drugs by using our own routes.

Others

As for the other services, we arrange for custom synthesis, weighing compounds andimporting compounds client purchased. We also provide up to date information on laws
and regulations on chemicals and a support service for managing regulated compounds.

ServiceDetails

Raw materials

We sell raw materials and intermediates manufactured under GMP.

Formulations

We act as an agent in collaborative development and marketing, and commissioning themanufacturing, of ethical pharmaceuticals, over-the-counter drugs, health foods, etc.

Bulk meterials

We provide reagents, intermediates and raw materials, manufactured anywhere in theworld, but especially in China, to parties involved in research and development in various
fields of chemistry.

5Corporate Profile

Principal Clients
Ajinomoto Co., Inc.
Amakasu Chemical Industries Inc.
AS ONE Corporation
Asahi Kasei Pharma Corporation
ASKA Pharmaceutical Co., Ltd.
Astellas Pharma Inc.
Axcelead Drug Discovery Partners, Inc.
Carna Biosciences Inc.
Chugai Pharmaceutical Co., Ltd.
Daiichi Sankyo Co., Ltd.
Daiichi Sankyo RD Associe Co., LTD
Dainippon Sumitomo Pharma Co., Ltd.
EA Pharma Co., Ltd.
Eisai Co., Ltd.
FANCL Corporation
FUJIFILM Corporation
FUJIFILM Toyama Chemical Co., Ltd.
FUJIFILM Wako Pure Chemical Corporation
Hamari Chemicals, Ltd.
Hisamitsu Pharmaceutical Co., Inc.
HOKKO CHEMICAL INDUSTRY CO., LTD.
Honzo Co., Ltd.
Ishihara Sangyo Kaisha Ltd.
Iwai Chemicals Company
Iwaki & Co., Ltd.
Iwaki Seiyaku Co., Ltd.
Japan Tobacco Inc.
Juzen Chemical Corporation
Kaken Pharmaceutical Co., Ltd.
Kirin Holdings Co., Ltd.
Kishida Chemical Co., Ltd.
Kissei Pharmaceutical Co., Ltd.
KNC Laboratories Co., Ltd.
Kobayashi Kako Co., Ltd.
Kobe University
Kotobuki Pharmaceutical Co., Ltd.
Kowa Company, Ltd.
KUMIAI CHEMICAL INDUSTRY CO., LTD.
Kureha Corporation
Kyorin Pharmaceutical Co., Ltd.
Kyoto University
Kyowa Hakko Kirin Co., Ltd.
Maruho Co., Ltd.
Medisa Shinyaku Inc.
Meiji Co., Ltd.
Meiji Seika Pharma Co., Ltd.
Mitsubishi Chemical Corporation
Mitsubishi Tanabe Pharma Corporation
Mitsui Chemicals Agro, Inc.
Mitsui Chemicals, Inc.
Mochida Pharmaceutical Co., Ltd.
Mylan Inc.
Nacalai Tesque
NARD institute, Ltd.
National Institute of Advanced Industrial Science and Technology
National Institutes for
Quantum and Radiological Science and Technology
Nichi-Iko Pharmaceutical Co., Ltd.
NIHON NOHYAKU CO.,LTD.
Nippon Chemiphar Co., Ltd.

Nippon Funmatsu Yakuhin Co., Ltd.
Nippon Kayaku Co., Ltd.
Nippon Shinyaku Co., Ltd.
Nippon Soda Co., Ltd.
Nipro Genepha Corporation
Nipro Pharma Corporation
Nissan Chemical Corporation
Nisshin Pharma Inc.
Nisshin Seifun Group Inc.
Nitto Medic Co., Ltd.
OAT Agrio Co., Ltd.
Ogawa & Co., Ltd.
Ohara Pharmaceutical Co., Ltd.
Ono Pharmaceutical Co., Ltd.
Osaka University
Otsuka Pharmaceutical Co., Ltd.
PeptiDream Inc.
PRISM BioLab Co., Ltd.
RaQualia Pharma Inc.
RIKEN
Ryukakusan Co., Ltd.
Santen Pharmaceutical Co., Ltd.
Sanwa Kagaku Kenkyusyo Co., Ltd.
Sanyo Chemical Laboratory Co., Ltd.
Sato Pharmaceutical Co., Ltd.
Sawai Pharmaceutical Co., Ltd.
SEKISUI MEDICAL CO., LTD.
Shionogi & Co., Ltd.
Shiseido Co., Ltd.
Shizuoka Institute of Environment and Hygiene
Societe des Produits Nestle S.A.
SUMIKA TECHNOSERVICE CORPORATION
Sumitomo Chemical Co., Ltd.
Sumitomo Dainippon Pharma Co., Ltd.
Taiho Pharmaceutical Co., Ltd.
Taisho Pharmaceutical Co., Ltd.
Takeda Pharmaceutical Co., Ltd.
Tatsumi Kagaku Co., Ltd.
Teijin Pharma Limited
Teva Takeda Pharma Ltd.
Teva Takeda Yakuhin Ltd.
The University of Tokyo
Toa Eiyo Ltd.
Toa Pharmaceuticals Co., Ltd.
Tokai Capsule Co., Ltd.
Tokyo Institute of Technology
Tokyo Medical and Dental University
Toray Industries, Inc.
Towa Pharmaceutical Co., Ltd.
TSUMURA & CO.
UBE INDUSTRIES,LTD.
University of Shizuoka
Wakamoto Pharmaceutical Co., Ltd.
Wakunaga Pharmaceutical Co., Ltd.
Yakult Honsha Co., Ltd.
Yokohama City University
Yoshindo Inc.
Zenyaku Kogyo Co., Ltd.
ZERIA Pharmaceutical Co., Ltd.

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Corporate Profile

Compound Suppliers

General Agencies in JapanCountry

AnalytiCon Discovery GmbH
Enamine Ltd.
Farmabios S.p.A
Pharmeks Ltd.

Germany
Ukraine
Italy
RussiaAgencies
USA
USA
USA
USA
China
China
USA
UK
USA
USA
USA
China
UK
Switzerland
China
USA
UK
USA
LatviaUSA
Ukraine
China
USA
UK
CanadaUSA
UK
PolandChina
Ukraine
China
USA
Germany
India
Switzerland
China
China
Hungary
China
India
CanadaUkraineRussiaChina
USA

Accela ChemBio Inc.
ACROBiosystems Inc.
Advanced ChemBlocks, Inc.
AK Scientific, Inc.
Allychem Co., Ltd
Angene International Limited
AOBIOUS INC
Apollo Scientific Ltd,Ark Pharm, Inc.
Asinex Corporation
AstaTech, Inc.
BioBioPha Co., Ltd.
Biorelevant.com Ltd
BIOSYNTH AG
BLD Pharmatech Ltd
BroadPharm
Butt Park Ltd.
Chem-Impex International, Inc.
ChemSpace
Combi-Blocks. Inc.
FCH Group
GL Biochem (Shanghai) Ltd.
J & W Pharmlab, LLC
Key Organics, Ltd.
Life Chemicals Inc.
Matrix Scientific
MAYBRIDGE
Natalex S.A.
Novochemy Limited
OTAVA
PharmaBlock Sciences (Nanjing), Inc.
Princeton Biomolecular Inc.
RCA e.K.
Sai Life Sciences Ltd.
Senn Chemicals AG
Shanghai Haoyuan Chemexpress Co., Ltd.
Shanghai Medicilon Inc.
SONEAS Chemicals Ltd.
Sundia MediTech Company, Ltd.
Syngene International Ltd,
Toronto Reserch chemicals Inc.
UkrOrgSynthesis Ltd.
Vitas-M Laboratory, LTD.
WuXi AppTec Co., Ltd.
Zelinsky Institute Inc.

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Corporate ProfileLocation
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FAX : +81-3-3352-2196

Toei-Shinjuku Line
4-minute walk from Exit C7 of Shinjuku 3-chome Station
Tokyo Metro Fukutoshin Line
4-minute walk from Exit C7 of Shinjuku 3-chome Station
Tokyo Metro Marunouchi Line
5-minute walk from Exit 1 of Shinjuku Gyoen Station
JR Line13-minute walk from East Exit or South Exit of Shinjuku Station

Shinjuku 2 Post oﬃce

Osaka BranchKeiha〒541-0044
n MainLine

Okadafushimimachi Bldg. 5-7 Fushimimachi 2-chome,Chuo-ku, Osaka 541-0044 JAPANTEL : +81-6-6231-5444 FAX : +81-6-6233-6540
info-west@namiki-s.co.jp

NAMIKI SHOJI CO., LTD.

SMBC
Fushimi post oﬃce

Li neSaintmarc cafe
3S h in2ju kKitahama Station

Sankyubashisuji

Yodoyabashi Station

Midosuji LIne

Sunkusin ju ku

Kensei Shinjuku Bldg. 5-3 Shinjuku 5-chome,Shinjuku-ku, Tokyo 160-0022 JAPANTEL : +81-3-3354-4026
info@namiki-s.co.jp

To sab ori Do ri

APA Villa Hotel
11

Fushimimachi3FamilyMartetchShinjuku Gyoen

Tokyo-Mitsubishi UFJ13To ei ShNIPPON
RENT-A-CARku
St Saat nchoionm

PoliceC7ju〒160-0022

TEPCO

ISETAN
Parking

ISETANinHead Office

NAMIKI SHOJI CO., LTD.

Marui MenetGenkaitre

YachiyoBank

JR Shinjuku
StationEast EntranceShukuKitahama
Tower

Osaka Subway Midosuji Line
5-minute walk from Exit 13 of Yodoyabashi Station
Osaka Subway Sakaisuji Line
5-minute walk from Exit 6 of Kitahama Station

Development Services

Online chemical structural database

ChemCupid, developed by Namiki Shoji, is the first Japanese online chemicaldatabase. Appropriate compounds, such as high-throughput screening compounds,building blocks, and reagents, can be found easily, by means of simple operations.

Database characteristics
01 Free to use
02 Contains data on 7.5million compounds with high availability
03 Search by importing files such as SDF, mol or Excel files
04 Online search by drawing structures
05 Downloads search results, using SDF, mol or Excel files
06 Can make inquires for prices and availabilities

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