染川智 院長

英文論文リスト

1: Somekawa S, Imagawa K, Hayashi H, Sakabe M, Ioka T, Sato GE, Inada K,Iwamoto T, Mori T, Uemura S, Nakagawa O, Saito Y. Tmem100, an ALK1 receptor
signaling-dependent gene essential for arterial endothelium
differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012
Jul 24;109(30):12064-9.
2: Somekawa S, Fukuhara S, Nakaoka Y, Fujita H, Saito Y, Mochizuki N.
Enhanced functional gap junction neoformation by protein kinase
A-dependent and Epac-dependent signals downstream of cAMP in cardiac
myocytes. Circ Res. 2005 Sep 30;97(7):655-62.
3: Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, Takeda
Y, Kawata H, Horii M, Nakajima T, Uemura S, Mochizuki N, Saito Y. Regulationof aldosterone and cortisol production by the transcriptional repressor
neuron restrictive silencer factor. Endocrinology. 2009
Jul;150(7):3110-7.
4: Mizuta K, Sakabe M, Somekawa S, Saito Y, Nakagawa O. TMEM100: A Novel
Intracellular Transmembrane Protein Essential for Vascular Development andCardiac Morphogenesis. 2016 Jun 25. In: Nakanishi T, Markwald RR, Baldwin
HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology andMorphogenesis of Congenital Heart Disease: From Gene Function and CellularInteraction to Morphology. Springer; 2016.
5: Nakagawa H, Somekawa S, Onoue K, Kumazawa T, Ueda T, Seno A, Nakada Y,Nakano T, Matsui M, Soeda T, Okayama S, Kawakami R, Kawata H, Okura H, Saito
Y. Salt accelerates aldosterone-induced cardiac remodeling in the absenceof guanylyl cyclase-A signaling. Life Sci. 2016 Nov 15;165:9-15.
6: Seno A, Takeda Y, Matsui M, Okuda A, Nakano T, Nakada Y, Kumazawa T,Nakagawa H, Nishida T, Onoue K, Somekawa S, Watanabe M, Kawata H, KawakamiR, Okura H, Uemura S, Saito Y. Suppressed Production of Soluble Fms-Like
Tyrosine Kinase-1 Contributes to Myocardial Remodeling and Heart Failure.
Hypertension. 2016 Sep;68(3):678-87.

7: Tsukamoto S, Kurematsu Y, Honoki K, Kido A, Somekawa S, Kaya D, Sadamitsu
T, Fukui H, Tanaka Y. Severe toxicity of chemotherapy against advanced soft
tissue sarcoma in Werner's syndrome: Ifosfamide-induced encephalopathy
with central diabetes insipidus. J Orthop Sci. 2016 May;21(3):403-6.
8: Mizuta K, Sakabe M, Hashimoto A, Ioka T, Sakai C, Okumura K, Hattammaru
M, Fujita M, Araki M, Somekawa S, Saito Y, Nakagawa O. Impairment ofendothelial-mesenchymal transformation during atrioventricular cushion
formation in Tmem100 null embryos. Dev Dyn. 2015 Jan;244(1):31-42.
9: Ueda T, Kawakami R, Horii M, Sugawara Y, Matsumoto T, Okada S, Nishida
T, Soeda T, Okayama S, Somekawa S, Takeda Y, Watanabe M, Kawata H, Uemura
S, Saito Y. Noncardiovascular death, especially infection, is a significant
cause of death in elderly patients with acutely decompensated heart failure.
J Card Fail. 2014 Mar;20(3):174-80.
10: Okayama S, Soeda T, Kawakami R, Takami Y, Somekawa S, Ueda T, Sugawara
Y, Matsumoto T, Sung JH, Nishida T, Uemura S, Saito Y. Evaluation of coronary
artery disease and cardiac morphology and function in patients withhypertrophic cardiomyopathy, using cardiac computed tomography. HeartVessels. 2015 Jan;30(1):28-35.
11: Okayama S, Nakano T, Uemura S, Fujimoto S, Somekawa S, Watanabe M,Nakajima T, Saito Y. Evaluation of left ventricular diastolic function byfractional area change using cine cardiovascular magnetic resonance: afeasibility study. J Cardiovasc Magn Reson. 2013 Sep 26;15:87.
12: Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima
H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, KawakamiR, Nakatani K, Iwano M, Saito Y. Suppressed soluble Fms-like tyrosine
kinase-1 production aggravates atherosclerosis in chronic kidney disease.
Kidney Int. 2014 Feb;85(2):393-403.
13: Okada S, Morimoto T, Ogawa H, Sakuma M, Soejima H, Nakayama M, Sugiyama
S, Jinnouchi H, Waki M, Doi N, Horii M, Kawata H, Somekawa S, Soeda T, Uemura

S, Saito Y; investigators for the Japanese Primary Prevention ofAtherosclerosis with Aspirin for Diabetes (JPAD) trial. Effect of low-dose
aspirin on primary prevention of cardiovascular events in Japanese diabetic
patients at high risk. Circ J. 2013;77(12):3023-8.
14: Ueda T, Kawakami R, Horii M, Sugawara Y, Matsumoto T, Okada S, Nishida
T, Soeda T, Okayama S, Somekawa S, Takeda Y, Watanabe M, Kawata H, Uemura
S, Saito Y. High mean corpuscular volume is a new indicator of prognosis
in acute decompensated heart failure. Circ J. 2013;77(11):2766-71.
15: Matsumoto T, Uemura S, Takeda Y, Matsui M, Okada S, Nishida T, Soeda
T, Okayama S, Somekawa S, Ishigami K, Onoue K, Kawata H, Kawakami R, Horii
M, Saito Y. An elevated ratio of placental growth factor to soluble fms-liketyrosine kinase-1 predicts adverse outcomes in patients with stablecoronary artery disease. Intern Med. 2013;52(10):1019-27.
16: Arimura T, Onoue K, Takahashi-Tanaka Y, Ishikawa T, Kuwahara M, Setou
M, Shigenobu S, Yamaguchi K, Bertrand AT, Machida N, Takayama K, Fukusato
M, Tanaka R, Somekawa S, Nakano T, Yamane Y, Kuba K, Imai Y, Saito Y, Bonne
G, Kimura A. Nuclear accumulation of androgen receptor in gender differenceof dilated cardiomyopathy due to lamin A/C mutations. Cardiovasc Res. 2013
Aug 1;99(3):382-94.
17: Horii M, Matsumoto T, Uemura S, Sugawara Y, Takitsume A, Ueda T, Nakagawa
H, Nishida T, Soeda T, Okayama S, Somekawa S, Ishigami K, Takeda Y, Kawata
H, Kawakami R, Saito Y. Prognostic value of B-type natriuretic peptide andits amino-terminal proBNP fragment for cardiovascular events withstratification by renal function. J Cardiol. 2013 Jun;61(6):410-6.
18: Okayama S, Soeda T, Takami Y, Kawakami R, Somekawa S, Uemura S, Saito
Y. The influence of effective energy on computed tomography number depends
on tissue characteristics in monoenergetic cardiac imaging. Radiol ResPract. 2012;2012:150980.
19: Takami T, Yamano S, Okada S, Sakuma M, Morimoto T, Hashimoto H, Somekawa
S, Saito Y. Major risk factors for the appearance of white-matter lesions

on MRI in hypertensive patients with controlled blood pressure. Vasc Health
Risk Manag. 2012;8:169-76.
20: Nishida T, Nakajima T, Kaitani K, Takitsume A, Soeda T, Okayama S,Somekawa S, Takeda Y, Ishigami K, Kawata H, Kawakami R, Horii M, Uemura
S, Saito Y. Non-contact mapping system accurately localizes right-sided
accessory pathways in type B Wolff-Parkinson-White syndrome. Europace.
2012 May;14(5):752-60.
21: Sakan H, Okayama S, Uemura S, Somekawa S, Ishigami K, Takeda Y, Kawata
H, Horii M, Fujimoto S, Saito Y. Atrial right-to-left shunt without
pulmonary hypertension in a patient with biventricular non-compaction
cardiomyopathy accompanied by ventricular and atrial septal defects.
Intern Med.2011;50(16):1747-51.
22: Uemura S, Ishigami K, Soeda T, Okayama S, Sung JH, Nakagawa H, Somekawa
S, Takeda Y, Kawata H, Horii M, Saito Y. Thin-cap fibroatheroma andmicrochannel findings in optical coherence tomography correlate withsubsequent progression of coronary atheromatous plaques. Eur Heart J. 2012
Jan;33(1):78-85.
23: Soeda T, Uemura S, Okayama S, Kawakami R, Sugawara Y, Nakagawa H,Matsumoto T, Sung JH, Nishida T, Senoo A, Somekawa S, Takeda Y, Ishigami
K, Kawata H, Horii M, Saito Y. Intensive lipid-lowering therapy withrosuvastatin stabilizes lipid-rich coronary plaques. -Evaluation using
dual-source computed tomography. Circ J. 2011;75(11):2621-7.
24: Okayama S, Seno A, Soeda T, Takami Y, Kawakami R, Somekawa S, Ishigami
K, Takeda Y, Kawata H, Horii M, Uemura S, Saito Y. Optimization of energy
level for coronary angiography with dual-energy and dual-source computedtomography. Int J Cardiovasc Imaging. 2012 Apr;28(4):901-9.
25: Okayama S, Ayako S, Somekawa S, Uemura S, Kubota Y, Saito Y. Feasibilityof dual gradient-echo in-phase and opposed-phase magnetic resonanceimaging for the evaluation of epicardial fat. Acta Radiol. 2011 Sep
1;52(7):723-9.

26: Soeda T, Okayama S, Seno A, Kawakami R, Somekawa S, Takeda Y, Uemura
S, Saito Y. Contrast-enhanced computed tomographic and echocardiographic
detection of intra-aortic floating thrombus causing acute myocardial
infarction. J Cardiovasc Comput Tomogr. 2011 Jan-Feb;5(1):63-5.
27: Okayama S, Uemura S, Sugimoto H, Enomoto S, Onoue K, Omori S, Soeda
T, Somekawa S, Ishigami K, Watanabe M, Nakajima T, Kubota Y, Saito Y. Dual
gradient-echo in-phase and opposed-phase magnetic resonance imaging toevaluate lipomatous metaplasia in patients with old myocardial infarction.
Magn Reson Med Sci. 2010;9(2):85-9.
28: Okayama S, Uemura S, Soeda T, Onoue K, Somekawa S, Ishigami K, Watanabe
M, Nakajima T, Fujimoto S, Saito Y. Clinical significance of papillarymuscle late enhancement detected via cardiac magnetic resonance imaging
in patients with single old myocardial infarction. Int J Cardiol. 2011 Jan7;146(1):73-9.
29: Okayama S, Uemura S, Watanabe M, Morikawa Y, Onoue K, Soeda T, Iwama
H, Somekawa S, Takeda Y, Uramoto H, Kobayashi Y, Saito Y. Novel application
ofblack-blood echo-planar imaging to the assessment of myocardialinfarction. Heart Vessels. 2010 Mar;25(2):104-12.
30: Soeda T, Uemura S, Morikawa Y, Ishigami K, Okayama S, Hee SJ, Nishida
T, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y. Diagnostic
accuracy of dual-source computed tomography in the characterization ofcoronary atherosclerotic plaques: comparison with intravascular opticalcoherence tomography. Int J Cardiol. 2011 May 5;148(3):313-8.
31: Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Imagawa K, Nishida
T, Morikawa Y, Takemoto Y, Asai O, Soeda T, Okayama S, Ishigami K, Nakatani
K, Kawata H, Horii M, Nakajima T, Akai Y, Iwano M, Saito Y. Reduction ofcirculating soluble fms-like tyrosine kinase-1 plays a significant role
in renal dysfunction-associated aggravation of atherosclerosis.
Circulation. 2009 Dec 15;120(24):2470-7.

32: Onoue K, Uemura S, Takeda Y, Somekawa S, Iwama H, Nishida T, Morikawa
Y, Nakagawa H, Tsutsumi T, Sung JH, Takemoto Y, Soeda T, Okayama S, Ishigami
K, Kawata H, Horii M, Nakajima T, Saito Y. Usefulness of soluble Fms-liketyrosine kinase-1 as a biomarker of acute severe heart failure in patientswith acute myocardial infarction. Am J Cardiol. 2009 Dec 1;104(11):1478-83.
33: Ishigami K, Uemura S, Morikawa Y, Soeda T, Okayama S, Nishida T, Takemoto
Y, Onoue K, Somekawa S, Takeda Y, Kawata H, Horii M, Saito Y. Long-term
follow-up of neointimal coverage of sirolimus-eluting stents--evaluation
with optical coherence tomography. Circ J. 2009 Dec;73(12):2300-7.
34: Morikawa Y, Uemura S, Ishigami K, Soeda T, Okayama S, Takemoto Y, OnoueK, Somekawa S, Nishida T, Takeda Y, Kawata H, Horii M, Saito Y. Morphologicalfeatures of coronary arteries in patients with coronary spastic angina:
assessment with intracoronary optical coherence tomography. Int J Cardiol.
2011 Feb 3;146(3):334-40.
35: Takeda Y, Uemura S, Iwama H, Imagawa K, Nishida T, Onoue K, Takemoto
Y, Soeda T, Okayama S, Somekawa S, Ishigami K, Takaoka M, Kawata H, Kubo
A, Horii M, Nakajima T, Saito Y. Treatment with recombinant placental growth
factor (PlGF) enhances both angiogenesis and arteriogenesis and improves
survival after myocardial infarction. Circ J. 2009 Sep;73(9):1674-82.
36: Takemoto Y, Kawata H, Soeda T, Imagawa K, Somekawa S, Takeda Y, Uemura
S, Matsumoto M, Fujimura Y, Jo J, Kimura Y, Tabata Y, Saito Y. Humanplacental ectonucleoside triphosphate diphosphohydrolase gene transfer
via gelatin-coated stents prevents in-stent thrombosis. Arterioscler
Thromb Vasc Biol. 2009 Jun;29(6):857-62.
37: Okayama S, Matsui M, Somekawa S, Iwano M, Saito Y. Non-contrast MRI
for the evaluation of hydronephrotic and dysfunctioning kidney secondaryto testicular cancer. Ren Fail. 2009;31(2):153-8.
38: Okayama S, Hirai T, Yamashita N, Somekawa S, Iwano M, Uemura S, Kanauchi
M, Saito Y. Contrast-enhanced ultrasonography with Sonazoid for evaluationof renal microcirculation. J Med Ultrason (2001). 2008 Dec;35(4):183-9.

39: Okayama S, Uemura S, Nishida T, Morikawa Y, Onoue K, Takemoto Y, Soeda
T, Somekawa S, Ishigami K, Takeda Y, Horii M, Kawata H, Takaoka M, Nakajima
T, Saito Y. Progression of non-culprit coronary artery atherosclerosis
after acute myocardial infarction in comparison with stable angina pectoris.
J Atheroscler Thromb. 2008 Oct;15(5):228-34.
40: Zhang Q, Saito Y, Naya N, Imagawa K, Somekawa S, Kawata H, Takeda Y,Uemura S, Kishimoto I, Nakao K. The specific mineralocorticoid receptor
blocker eplerenone attenuates left ventricular remodeling in mice lacking
the gene encoding guanylyl cyclase-A. Hypertens Res. 2008
Jun;31(6):1251-6.
41: Okayama S, Imagawa K, Naya N, Iwama H, Somekawa S, Kawata H, Horii M,Nakajima T, Uemura S, Saito Y. Blocking T-type Ca2+ channels withefonidipine decreased plasma aldosterone concentration in healthy
volunteers. Hypertens Res. 2006 Jul;29(7):493-7.
42: Iwama H, Uemura S, Naya N, Imagawa K, Takemoto Y, Asai O, Onoue K, Okayama
S, Somekawa S, Kida Y, Takeda Y, Nakatani K, Takaoka M, Kawata H, Horii
M, Nakajima T, Doi N, Saito Y. Cardiac expression of placental growth factor
predicts the improvement of chronic phase left ventricular function inpatients with acute myocardial infarction. J Am Coll Cardiol. 2006 Apr18;47(8):1559-67.
43: Kogata N, Arai Y, Pearson JT, Hashimoto K, Hidaka K, Koyama T, Somekawa
S, Nakaoka Y, Ogawa M, Adams RH, Okada M, Mochizuki N. Cardiac ischemia
activates vascular endothelial cadherin promoter in both preexistingvascular cells and bone marrow cells involved in neovascularization. CircRes. 2006 Apr 14;98(7):897-904.
44: Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N,
Saito Y, Kangawa K, Mochizuki N. Cyclic AMP potentiates vascularendothelial cadherin-mediated cell-cell contact to enhance endothelial
barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol.
2005 Jan;25(1):136-46.