The 11th Annual Meeting of JSIT
2004 COnference on Immunotoxicology and Environmental Allergology in Fukui
2005.9.10-11. Fukui International Activities Plaza （Fukui）
President: Yukinori Kusaka (School of Medicine, University of Fukui)
Plenary Lecture <1>
Nanoparticles : a new frontier Professor Kenin particle toxicology
Donaldson, BSc, PhD,DSc, CBiol, FIBiol,FRCPath, FFOM

Professor of Respiratory
Toxicology, ELEGI Colt
Laboratory, Centre forInflammation Research,
Medical School, University of
Edinburgh, UK.

Plenary Lecture <2>
Environment and NasalAllergy

Prof. S. Fujieda

Fukui Medical University,Fukui, Japan

Yumiko Nakano

Osaka Prefectural Institute ofMini Lecture
Comparison of the effect ofcontact sensitizers andchemical - sensitivity inducing
substances using cDNA arrayayalysis

Public HealthSymposium <1>
DEvelopment of guidelines for Organizer
caring and preveting hazards

AtsushiUeda

Preventive andEnvironmental Medicine,

Kou
SakabeDepartment of Public Health,
Kitasato University School of
Pharmaceutical Sciences

Globally Harmonized System Muneyuki Miyagawaof classification and labelingof chemicals (GHS)（GHS）；
About the classification
standard of the chemical andthe compound based on
influence on health and theenvironmental impact

Dep. Research Planning ,National Institute ofOccupational Safety andHealth, Institute of Industrial
Health, Japan

From clinitian's (internalmedicine department)
standpoint

Kunio Dobashi

Depatment of Physical
Therapy (Basic PhysicalTherapy), Allergy Respiratory Medicine, Gunma
University Faculty ofMedicine School of Health
Sciences

Skin disorders with allergic
chemical -- Current status

Yoko Kataoka

Department of Dermatology,
Osaka Prefectural Medical

due to sensitizing chemicals
according to a globally
harmonized system ofclassification and labeling ofchemicals (GHS)

Faculty of Medical andPharmaceutical Sciences,
Kumamoto University

and problems of prevention

Center for Respiratory andand measures

Allergic Diseases

The management of theSaburo Nakata

chemical: From producer's

The Japan Chemical Industry
Associationstandpoint
Chemical management andShigeharu Nakachi

GHS by citizen's participation

Environmental Monitoring
Laboratory (EML), The TOxic
Watch Network (T-Watch)

Sensitizer in conformity withKazuhiko Sato

Department of

globally harmonized system

Environmental Health,

GHS (provisional list)

School of Medicine,
University of Fukui

Symposium <2>
New Evidence from Animal

Organizer

MOdel for Respiratory Allergy
and NanotoxicologyThe evaluation of cellular
toxicity by using murine
alveolar macrophage lineage
cells

Kenzo

Nagoya University Schoool of

TakakiMedicine, School of Health
Scieneces

Fujio
KayamaCenter for Community
Medicine, Division ofEnvironmental Medicine,
Jichi Medical School

Masashi Tsunoda et al

Kitasato University, School ofMedicine, Department ofPreventive Medicine andPublic Health, Sagamihara,
Japan

Effect of intratracheal
Tin-Tin-Win-Shwe et al
instillation of nanoparticles on
chemokine protein releaseand mRNA expression in lungand lymph node in mice

National Institute forEnvironmental Studies,
Tsukuba, Japan

Synergistic effect of ultrafine Shoji Yamamoto et alcarbon particles on lipoteichoi
acid-induced early pulmonary
inflammation.

Environmental Health
Sciences Division, NationalInstitute for EnvironmentalStudies, Tsukuba, Japan

Elevated IgE to Cryptomeria
japonica pollen in rats
exposed to diesel exhaust
during fetus

Nobue Watanabe

Department ofEnvironmental Health andToxicology, Tokyo
Metropolitan Institute of
Public Health

Improving lung function
testing in animal to detectallergenicity of inhaled
substances

Dr. Armin Broun

Immunotoxicology andImmunology/Allergy Dept.,
Immunology, Allergology andclinical Inhalation Division,
Fraunhofer-Institut fur
Toxikologie undExperimentelle Medizin ITEM, Hannover, Germany

Organizer

Eiji Maki

Yanssen Pharmaceutical K.
K. Tokyo, Japan

Jun-ichi
SawadaDivision of Biochemistry andImmunochemistry, NationalWorkshop
Non-RI use substitution
immunotoxicity examination
method: Alternative methodof LLNA and NK activity
measurement

Institute of Health Sciences,
Tokyo, Japan
Pharmaceuticals

Naohisa Tsutsui

Manufacturers Association

Mitsubishi Pharma
Corporation

joint research reportconcerning LLNA method
BrdU method as LLNA

Masahito Takeyoshi

substitution method

Chemicals Assessment
Center, Chemicals Evaluation
and Research Institute

LLNA-DA method as Non-RI

Kunihiko Yamashita

substitution method

Daicel Chemical Industries,
Ltd.,

Flow cytometric assay of NK

Seiji Shibata, Shigeru

Safety & Pharmacokinetics

cell function using

HisadaResearch Department,

fluorescence method and its

Teikoku Hormone Mfg.Co.,

relationship to phenotyping

Ltd., Kawasaki, Japan

Natural killer cell activity uses Ngata M, Kanasaki K,
fluorochrome
Nakamura K

Developmental researchLaboratories, Shionogi & Co.,
Ltd., Osaka, Japan

General Presentation
Examination of T celldependent antigen inantibody production
measurement

Nagata M, Nakamura K Developmental researchLaboratories, Shionogi & Co.,
Ltd., Osaka, Japan

Improvement of an enzyme
linked immunosorbent assay(ELISA) using whole sheep
red blood cell.

Ai Minakawa et al

Tsukuba Safety Assessment
Laboratories, Banyu
Pharmaceutical Co.,Ltd.,
Ibaragi, Japan

Improved whole SRBC-ELISA Hiroshi Watanabe et al
method for detection ofprimary antibody response toSRBC in rats

Tsukuba Safety Assessment
Laboratories, Banyu
Pharmaceutical Co.,Ltd.,
Ibaragi, Japan

Development of a modified
LLNA with non-radio isotopic

Daicel Chemical Industries,
LTD

Kenji Idehara et al

endpoint.
Evaluation of theKenji Idehara et al
performance of LLNA-DA withDaicel ChemicalIndustries,LTD.

known dermal sensitizers.
An estimable method of skinsensitization test for metallic
medical devices

Yukiko Kanazawa

Food and Drug Safety
Center, Kanagawa, Japan

Murine Food Allergy Model

Tomoko Shindo et al

Hatano Research Institute,with Oral Sensitization andOral Challenge(3)Food and Drug Safety
Center, Kanagawa, Japan

Effects of indomethacin
Kiyoshi Kushima, Kenjiadministered in late-gestation Hoshino

Safety ResearchLaboratories, Yamanouchi

on the development ofimmune system in rat pups.

Pharmaceutical Co.,Ltd.

Effects on immune-response

Koichi Hayashi, Tadashi Institure of Environmental

to SRBC-antigen in theimmature rats exposed toKosaka, Yukari Tajima,Hideaki Fujie, Tsutomu

methoxychlor during theMatsumoto, Yasufumi

Toxicology, Ibaragi, Japanprenatal and postnatal

Shutoh and Takanori

period.

HaradaSoy-diet accelerates
proteinuria in autoimmune
MRL/Mp-lpr/lpr mice

Zhao Jian-Hong, Sun
Su-Ju,Kayama Fujio

Department ofEnvironmental Medicine,Center for Community
Medicine, Jichi MedicalSchool, Tochigi, Japan

Alternation of IL-Yoshie Miura et al

10production in chrisotile-Bresistant human polyclonal T

Department of Hygiene,
Kawasaki Medical School,
Okayama, Japan

cell line MT-2
Apoptosis-inducing effect ofTakemi Otsuki et alasbestos (chrysotile) on
human T cell line (MT-2) and

Department of Hygiene,
Kawasaki Medical School,
Okayama, Japan

cellular biological changes in
sub-line of MT-2, which
acquired resistance tochrysotile-induced apoptosis
by long-term and low-dose
exposure to chrysotile
A case of occupational
asthma due to import wood

Hitoshi Kobayashi

white ash.

The Third of Internal
Medicine, School of Medicine,Iwate Medical University,
Iwate, Japan

Occupation dog allergy

Atsushi Usami

Tokai Pollen Institute

Development of rhinitis andasthma in occupation allergy

Atsushi Usami

Tokai Pollen Institute

Assessment of the skinKenji Idehara

Daicel Chemicalsensitization potential of
isocyanates and epoxy

Industries,LtD.

compounds using themodified non-RI local lymph
node assay.
Airway Inflammatory andKui-Cheng Zheng

Department of

Immunological Events in a
Rat Model Exposed to Toluene

Environmental andPreventive Medicine, School

Diisocyanateof Medicine, University ofRyukyu, Okinawa , Japan

Hypersensitivity of miceinduced by diisocyanate-Nobuhiro Nishio et al

Suppressive effects byfastingA case of tunneling worker

Department of Hygiene,
Kansai Medical University ,Osaka, Japan

Kenji Tsushima et alwith isocyanate inducedasthma

First Department of Internal
Medicine, Shinshu University
School of Medicine, Nagano,Japan

Three cases of occupational

Ichiro Hara, Kaoru

Osaka Occupational Healthallergic dermatitis due toepoxy resin

Mitsuya

Promotional Center, Osaka,Japan

Importance of allergic,

Susumu Nakamura

Oita University, Oita, Japanimmunological management
in office that causes
occupation allergy

Th1/Th2 balance in mice

Kazuo Takahashi et al

exposued to Tributyltin oxide

Department ofEnvironmental ImmunoDermatology, Yokohama City
University Graduate Schoolof Medicine, Yokohama,Japan

Immunodisruptive effects ofTeruaki Sakurai et al

Laboratory of Environmental

arsenic on macrophagegeneration from human

Chemistry, School of Life
Science, Tokyo University of

peripheral blood monocytes

Pharmacy and Life Science,Tokyo, Japan

Effect of dimethyl2,2dichlorovinyl phosphate

Qing Li et al(DDVP) on perforin,
granzyme A and granulysin in

Department of Hygiene andPublic Health, Nippon
Medical School, Tokyo, Japan

human NK-92CI cell line
Fundamental studies on
effects of 17 β-estradiol onmouse contact dermatitis.

Humitoshi Sakazaki etal

Development ofEnvironmental Health,
Faculty of PharmaceuticalSciences, Setsunan
UniversityThe analysis of Major

Qingjun Wei

Department ofchemical components of theJapanese ginger and their

Environmental andPreventive Medicine,

primary irritation

Graduate School of Medical
Sciences of Kumamoto
University, Kumamoto, Japan

Survey of food-and inhaled-

Reiko Teshima et al

allergen specific IgE antibody
in the sera of children aged

National Institute of Health
Sciences, Tokyo, Japan

three years
Association of allergic

Takaaki Kondo et aldiseases with serum lipid
profile and inflammatory

Nagoya University School ofHealth Sciences, Nagoya,Japan

markers among healthy
workers
Evaluation of DNA extraction

Yasuo Takeuchi et al

Clinical research Center formethods from house dust for
the quantitative detection offungi using real-time PCR

Allergy and Rheumatology,
National Hospital
Organization Sagamihara

analysis

National Hospital

A case of hypersensitivity
Takashi Mouri et alpneumonitis that was present

The third department ofinternal medicine, school ofin Shiitake cultivator

medicine, Iwate MedicalUniversity, Iwate, Japan

A case of hypersensitivitypneumonitis induced bay

Kitsukawa Y et al

Trichoderma viride
Indoor allergen survey in thehouses of student in theveterinary medicine

Pulmonary Medicine &Clinical Immunology, Dokkyo
University School ofMedicine, Toshigi, Japan

Akiemi Saito et al

Clinical Research Center forAllergy and Rheumatology,
National Hospital
Organization Sagamihara
National HospitalCohortostadi of School of

Kato et al

Medicine, University of Fukui
Fukui of doctor's occupational
allergDepartment ofEnvironmental Health,
School of Medicine,
University of Fukui, Fukui,Japan

Pathogenesis of seasonalallergic rhinitis under natural

Kato M et al

allergen provocation

Department ofEnvironmental andPreventive Medicine,
Graduate School of Medical
Science, Kanazawa
University, Ishikawa, Japan

Epidemiology of the allergic

Nobuyasu Gama

rhinitis in Taxi Driver
Epidemiology of pollinosis in
middle aged population of a

Dokkyo University school ofMedicine, Otolaryngology

Yuriko Hashimoto et al

Tokyo University of Social
Welfare, Tokyo, Japan

Takako Matsui et al

Environmental Medicalvillage and a city in Gunma,
Japan, related to theirlifestyle factors
Clinical Study on Sick House
Syndrome and Atopic
Dermatitis, with Special

Center, Kitasato InstituteHospital, Tokyo, Japan

Reference to NeuroOphthalmological Analysis
Luncheon Seminar 1
Drug immunogenicity in non- Dr. Mark Wing
clinical studies

Head of ExperimentalBiology, Senior
Immunologist, Huntingdon
Life Science Ltd.

Luncheon Seminar 2
Preclinical and clinical studies Prof. Uwe Heinrichon pharmaceuticals andDirector, Fraunhofer-Institut
fur Toxikologie undbiopharmaceuticals (including

Experimentelle Medizin ITEM

an introduction of the, Hannover, Germany

Fraunhofer ITEM)
Immunotoxicology in therespiratory tractDr. Armin Broun

Immunotoxicology andImmunology/Allergy Dept.,
Immunology, Allergology andclinical Inhalation Division,
Fraunhofer-Institut furToxikologie undExperimentelle Medizin ITEM
, Hannover, Germany