The 27th Annual Meeting of the Japanese Society of Immunotoxicology
Program

September 26 (Saturday)■ 10：00 ～ 10：05

Opening Remark

The 27th Annual Meeting of the Japanese Society of Immunotoxicology
President: Masashi Tsunoda■ 10：10 ～ 13：55

Students and young Scientists Session ＜ Y-01 ～ Y-08 ＞

Chairperson: Etsushi Kuroda（Department of Immunology, Hyogo College of Medicine）
Eiko Koike (National Institute for Environmental Studies)■ 10：10 ～ 10：25
Y-01

Comparison between impact of oral exposure to Fumonisin B1 and B2 on the development ofcutaneous allergy○ Ai Morimoto1, Toa Ookawara1, Ryota Aihara1, Naoki Iwashita1,2, Yoshiichi Takagi1,3,Tomoki Fukuyama1
1

Azabu university, 2Bioalchemis, 3Japan SLC,Inc.

■ 10：30 ～ 10：45
Y-02

Acute and subacute oral toxicity of deoxynivalenol exposure in a Dermatophagoides farinae

induced murine asthma model○ Toa Ookawara1, Ryota Aihara1, Ai Morimoto1, Naoki Iwashita1,2, Yoshiichi Takagi1,3,Atsushi Miyasaka4, Masayo Kushiro5, Shiro Miyake1, Tomoki Fukuyama1
1

Azabu university, 2 Bioalchemis, 3 Japan SLC,Inc., 4 Kyushu Okinawa Research Center, NARO,5Food Research Institute, NARO

■ 10：50 ～ 11：05
Y-03

Impact of oral exposure to trichothecene mycotoxin Deoxynivalenol on the development ofpsoriasis in an imiquimod-induced mouse model○ Ryota Aihara1, Toa Ookawara1, Ai Morimoto1, Naoki Iwashita1,2, Yoshiichi Takagi1,3,Atsushi Miyasaka4, Masayo Kushiro5, Shiro Miyake1, Tomoki Fukuyama1
1

Azabu university, 2 Bioalchemis, 3 Japan SLC,Inc., 4 Kyushu Okinawa Research Center, NARO,

5

Food Research Institute, NARO

■ 11：10 ～ 11：25
Y-04

HLA allotype-specific skin toxicity using HLA transgenic mice
○ Yushiro Yamada, Shigeki Aoki, Sota Fujimori, Kousei Ito
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University－ 11 －■ 11：30 ～ 11：45
Y-05

I nvolvement of immunosuppressive systems in expression of HLA dependent drug

hypersensitivity caused by Abacavir○ Saki Kuwahara1, Takeshi Susukida1,2, Shigeki Aoki1, Kousei Ito1

12

Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University,
Institute of Natural Medicine, University of Toyama

ChairpersonHiroyuki Kojima,Yasumitsu Nishimura■ 13：00 ～ 13：15
Y-06The effect of triterpenoids ursolic acid and oleanolic acid on mitochondria in adult T cellleukemia cells.

○ Mengyue Shen, Ryoko Baba, Kentaro Morita, Duo Wang, Yusuke Sennari, Tamotsu Kanazawa,Yasuhiro YoshidaDepartment of Immunology and Parasitology, School of Medicine, University of Occupationaland Environmental Health, Japan■ 13：20 ～ 13：35
Y-07

Immunotoxicity of G-CSF through myeloid-derived suppressor cells in tumor-bearing mice

○ Yuuto Murata1, Takahiro Kawasaki1, Daisuke Okuzaki2,3, Naoki Okada1, Masashi Tachibana1,41
2
34Graduate School of Pharmaceutical Sciences, Osaka University,World Premier International Research Center Immunology Frontier Research Center, Osaka University,
The Research Institute for Microbial Diseases, Osaka University,

Global Center for Medical Engineering and Informatics, Osaka University■ 13：40 ～ 13：55
Y-08

Involvement of TLR Signaling on liver fibrosis of nash in rats fed cdaa diet

○ Kinuko Uno1, Katsuhiro Miyajima1,2,3, Noriko Kemuriyama3, Dai Nakae1,2,3

Department of Food and Nutrition Science, Faculty of Agriculture, Graduate School of Tokyo1 

University of Agriculture,

Department of Nutritional Science and Food Safety, Faculty of Agriculture, Graduate School of2 Tokyo University of Agriculture,

Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo3 

University of Agriculture■ 14：00 ～ 15：40

Symposium: Immunotoxicology, Past, Present and Future

Chairperson: Yasuo Yoshioka (Institute for Open and Transdisciplinary Research Initiatives, Osaka University)
Katsunori Yamaura (Keio University)■ 14：00 ～ 14：25
S-01

Role of gut microbiota in Theiler’s virus model for multiple sclerosis: Max Theiler and Hideyo

Noguchi〇 Ikuo Tsunoda1, Shigemitsu Toriyama212

Department of Microbiology, Kindai University Faculty of Medicine,
Faculty of Agriculture, the University of Tokyo－ 12 －■ 14：30 ～ 14：55
S-02

Vaccine Safety: Current Status and Challenges in the Development of Safe Potent Vaccines〇 Yasuo Yoshioka
1Institute for Open and Transdisciplinary Research Initiatives, Osaka University,

2

Research Institute for Microbial Diseases, Osaka University,

3

The Research Foundation for Microbial Diseases, Osaka University,

4

Graduate School of Pharmaceutical Sciences, Osaka University■ 15：00 ～ 15：25
S-03

Carcinogenesis of ovarian clear cell carcinoma through toxic metabolism〇 Masashi Takano
Department of Obstetrics and Gynecology, National Defense Medical CollegeDiscussion : 15：25 ～ 15：40

September 27 (Sunday)■ 10：20 ～ 11：55 “The 10th JSIT Award” and “The 10th JSIT prize for encouragement” lectures
Chairperson: Reiko Tejima（Okayama University of Science）■ 10：20 ～ 10：55
JSIT Award Lecture
AL-01

Investigation of Novel In Vitro Evaluation Methods for Prediction of In Vitro Immunotoxicity〇 Tomoaki Inoue
Former-Chugai Pharmaceutical Co., Ltd.
■ 11：00 ～ 11：25
JSIT Young Investigator Award Lecture
AL-02

Investigation of idiosyncratic drug toxicity using HLA transgenic mice
〇 Shigeki Aoki
Laboratory of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University■ 11：30 ～ 11：55
AL-03

Immune dysfunction derived from zinc deficiency exacerbates the Th2 cell - M2 macrophage
pathway〇 Takamasa Kido
D epartment of Public Health and Environmental Medicine, The Jikei University School ofMedicine－ 13 －■ 13：10 ～ 15：25

 orkshop “Development of the latest technology forW
immunotoxicity evaluation”

Chairperson : Seiji Kushima,Takao Ashikaga■ 13：10 ～ 13：35
WS-01

Single-cell imaging of inflammatory regulated cell death〇 Yoshitaka Shirasaki
Graduate school of Pharmaceutical Sciences, the University of Tokyo■ 13：40 ～ 14：05
WS-02

Application of LCI-S to immunotoxicity study〇 Etsushi Kuroda
Department of Immunology, Hyogo College of Medicine■ 14：05 ～ 14：30
WS-03

Mammalian synthetic biology using tissue engineering and micro-fluidic technology〇 Yoh-ichi Tagawa1 and Yoichi Fujiyama2
1

School of Life Science and Technology, Tokyo Institute of Techonology,

2

Bio-Industry Unit Technology Research Laboratory, Shimazu cooperation■ 14：35 ～ 15：00
WS-04

Non-clinical in vitro research on human immune physiology in drug development〇 Chiyomi Kubo1, Tomoaki Inoue2
1

Research Division, Chugai Pharmaceutical Co., Ltd.,

2Former- Research Division, Chugai Pharmaceutical Co., Ltd.

Discussion : 15：00 ～ 15：25■ 15：30

Closing remarks【Poster display 16 abstracts to be viewed on the web from September 23rd to 27th】
P-01

Impact of dietary exposure to tris(1,3-dichloro-2-propyl)phosphate in allergic asthmatic mice.
〇 Rie Yanagisawa1, Eiko Koike1, Tin-Tin Win-Shwe1, Maiko Kawaguchi2, Tsutomu Shimada3,Hirohisa Takano4

P-02

1

National Institute for Environmental Studies, 2 Meiji University, 3 Kanazawa University Hospital,

4

Kyoto University

Effects of oral exposure to tris(1,3-dichloro-2-propyl) phosphate on immune cells in a mousemodel of allergic asthma.
○ Eiko Koike1, Rie Yanagisawa1, Tin Tin Win Shwe1, Hirohisa Takano2
1

National Institute for Environmental Studies, 2 Kyoto University－ 14 －P-03

Dietary exposure to tris(1,3-dichloro-2-propyl) phosphate affects central nervous system inallergic asthmatic mice

○ Tin-Tin Win-Shwe1, Rie Yanagisawa1, Eiko Koike1, Hirohisa Takano2

1

P-04

P-05

National Institute for Environmental Studies, 2 Kyoto University

Di-(2-ethylhexyl) phthalate enhances release of cytokine from ILC2 in the presence of IL-33〇 Megumi Nagao1, Akiko Honda1,2, Michitaka Tanaka1, Hirohisa Takano1,2    
1Graduate School of Global Environmental Studies, Kyoto University,2Graduate School of Engineering, Kyoto University

2-Hydroxyethyl methacrylate induces IL-1 α production by murine keratinocytes.

○ Toshinobu Kuroishi1, Takahiro Kaji1, Kanan Bando1, 2, Shunji Sugawara2
1

Division of Oral Immunology,
Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of2 Dentistry
P-06

Role of costimulatory molecules in function of CD8+ lymphocytes exposed to asbestos during MLR〇 Naoko Kumagai-Takei, Yasumitsu Nishimura, Suni Lee, Kei Yoshitome, Tatsuo Ito, Takemi Otsuki
Department of Hygiene, Kawasaki Medical School

P-07

Functional analysis of MMP-7 in human T cell lines continuously exposed to asbestos fibers.

〇 Suni Lee, Shoko Yamamoto, Tamayo Hatayama, Tatsuo Ito, Naoko Kumagai-Takei,
Kei Yoshitome, Yasumitsu Nishimura, Takemi Otsuki
Department of Hygiene, Kawasaki Medical School

P-08

A ctivation of aryl hydrocarbon receptor by oral administration of benzo(a)pyrene

exacerbates the food allergic reaction in a mouse model of OVA-induced food allergy.
○ Hitoshi Tajima1, Risako Tajiki-Nishino1, Yuko Watanabe1, Tomoki Fukuyama1,2

P-09

1

Institute of Environmental Toxicology,

2

Azabu University Faculty of Veterinary Medicine, Pharmcology Laboratory

Estimation and Assessment of Personal Care Products Affecting Atopic Dermatitis〇 Saori Tan1, Akiko Honda1,2, Natsuko Miyasaka2, Michitaka Tanaka2, Shin Tamura1,Hitoshi Okano1, Zaoshi Wang1, Megumi Nagao2, Li Yinpeng1, Yuki Kan2, Kayo Ueda1,2,Hirohisa Takano1,2

P-10

1

Graduate School of Engineering, Kyoto University,

2

Graduate School of Global Environmental Studies, Kyoto University

T he different effect of administration of traditional Japanese medicines alone or in

combination on busulfan-induced aspermatogenesis.

〇 Ning Qu1, Masahiro Itoh2, Kaori Suyama1, Shogo Hayashi1, Kou Sakabe1
Department of Anatomy, Division of Basic Medical Science, Tokai University School of Medicine,1 Kanagawa, Japan.
2

Department of Anatomy, Tokyo Medical University－ 15 －P-11

Evaluation of cytotoxicity and efficacy of adjuvant-containing nasal vaccine using geneticmarkers○ Eita Sasaki1, Hideki Asanuma2, Haruka Momose1, Keiko Furuhata1, Takuo Mizukami1,
Isao Hamaguchi1
Department of Safety Research on Blood and Biological Products, National Institute of1 

Infectious Diseases, Japan,2

P-12

Influenza Virus Research Center, National Institute of Infectious Diseases, Japan

Evaluation of cytotoxicity and efficacy of adjuvant-containing nasal vaccine using genetic markers○ Eita Sasaki1, Hideki Asanuma2, Haruka Momose1, Keiko Furuhata1, Takuo Mizukami1,
Isao Hamaguchi1
Department of Safety Research on Blood and Biological Products, National Institute of1 

Infectious Diseases, Japan,2

P-13

Influenza Virus Research Center, National Institute of Infectious Diseases, JapanThe roles of unfold protein responses in cholera toxin B-induced interleukine-1 β production○ Izumi Sasaki1, Takashi Orimo1, Isui Harie1, Yuko Takisawa1, Ko-ichi Furukawa2,Tsuneyasu Kaisho1
1

Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University
Department of Immunology, Lifelong Sports and Health Sciences, Chubu University College of2 Life and Health Sciences
P-14

Mechanisms underlying SARS-CoV-2 spike protein-induced pro-inflammatory responses inmurine macrophages〇 Ken Shirato, Takako Kizaki
Department of Molecular Predictive Medicine and Sport Science, Kyorin University School ofMedicine

P-15

Roles of the endothelial cell-specific protein Robo4 in inflammation
Keisuke Shirakura1, William Aird2, Takefumi Doi1, 〇 Yoshiaki Okada1
1P-16

Graduate School of Pharmaceutical Sciences, Osaka University, 2 Harvard Medical School

Detecting immunotoxicity in vitro -Clinically relevant studies in the COVID 19 era
Shaheda S. Ahmed, Anne M. Dickinson
Alcyomics Ltd., Newcastle upon Tyne－ 16 －