The 18th Annual Meeting of JSIT
Invited Plenary Lecture
The Histamine H4 Receptor
Robin L. Thurmondand Immune Function

Johnson & Johnson
Pharmaceutical Research &Development, L.L.C., USA

Special Lecture

Environmental
contaminants and children’s Chisato Mori (1, 2)
health(1) Department of
Bioenvironmental Medicine,
Graduate School Medicine,
Chiba University， (2) Centerof Preventive Medical Science,
Chiba University

Master’s Lecture
Genetic risk factors related
to severe cutaneousadverse reactions

Nahoko Kaniwa

Division of Medicinal Safety
Science, National Institute ofHealth Sciences

Awards Lectures
JSIT AWARD for Distinguished Contribution
Regulation of drug- andstress esponsive-enzyme
Takemi Yoshida ( (1, 2)
expressions based on
immunological mechanisms(1) Council on Pharmacists
Credentials,Tokyo, Japan (2)Showa University, Tokyo,Japan

JSIT RESEARCH AWARD
Immunological bioassay for
Ryosuke Nakamura
infant food allergy
Symposium

Div. Novel Foods
Immunochem., Natl. Inst.
Health Sci.

“Food Allergy- From in vitro prediction test to clinical test –“Food Allergy, intestinal
Hiroshi Ohno
immunity and oral tolerance

Laboratory for Epithelial
Immunobiology, ResearchCenter for Allergy andImmunology, RIKEN,
Yokohama, JapanMaintenance of IL-4
production by CD4+T cells
in mesenteric lymph nodes
is indispensable in inducing
T cell-dependent foodallergic enteropathy

Department of Applied
Biological Chemistry, Graduate
School of Agriculture and Life
Science, The University ofTokyo, Tokyo, Japan

Development of new
diagnostic method forcross-reactivity between
food allergens

Haruyo NakajimaAdachi

Yasuto Kondo (1),(1) Fujita Health University,
Kazuo Ogura (1),The second Teaching Hospital,
Norihiko Naruse (1),Nagoya, Japan (2) Fujita
Noriko Hirata (1),Health University, Toyoake,
Satiko Suzuki (1),JapanHitoshi Ando (1), Kinichi
Tanaka (2), Yoichi
Nakajima (2), Chisato

Inuo (2), Ikuya Tusge(2), Atsuo Urisu (1)Animal Models to Assess
Protein Allergenicity: State

DuPont Agricultural
Gregory S. Ladicsof the Science
Workshop

Biotechnology, Wilmington,
DE, USA.

“Methods of Assessment for Developmental Immunotoxicity”

Developmental
Immunotoxicology: ‘Stateof-the-Science’

DuPont Agricultural
Gregory S. Ladics

A new assay system for)Department of Microbiology,

evaluation ofdevelopmental
Wataru Watanabe
immunotoxicity of chemicalcompounds using RSV

School of Pharmaceutical
Sciences, Kyushu University ofHealth and Welfare, Nobeoka,Japan

infection to offspring mice

Win-Shwe Tin-Tin
Studies on the effects of(1)，Kunugita Naoki
toluene exposure on(2)，Yoshida Yasuhiro
developing immune system (3)，Fujimaki
Hidekazu (4)The effect ofperinatal/infant
Methoxychlor exposure inrat immune system

Biotechnology, Wilmington,DE, USA

National Institute forEnvironmental Studies (1)National Institute of Public
Health (2) University ofOccupational andEnvironmental Health, Japan(3)
National Institute forEnvironmental Studies (4)Koichi Hayashi，Tadashi Institute of Environmental
KosakaToxicology, Ibaraki, Japan

Oral Presentations

Fetotoxicity ofnanomaterials for thedevelopment of safe
nanomaterials

Particulates induce
macrophages to produce
lipid mediators via the Syk
activation

Yasuo Yoshioka(1,2,3)，Kohei
Yamashita (1)，Kazuma Higashisaka(1)，Yuki Morishita(1)，Kazuya Nagano(3)，Yasuhiro Abe(3)，Haruhiko Kamada(2,3)，Shin-ichi
Tsunoda (2,3)，Hiromi
Nabeshi (1)，Itaru
Yanagihara (4)，Shigeru Saito5，Norio
Itoh (1)，Tomoaki
Yoshikawa (1)，Yasuo
Tsutsumi (1,2,3)

Etsushi Kuroda (1)，Yasuo Morimoro (2)(1) Laboratory of Toxicology
and Safety Science, Graduate
School of PharmaceuticalSciences, Osaka University,Osaka, Japan (2) The Center
for Advanced Medical
Engineering and Informatics,
Osaka University, Osaka,
Japan (3) Laboratory ofBiopharmaceutical Research,
National Institute of
Biomedical Innovation, Osaka,Japan (4) Department ofDevelopmental Medicine,
Osaka Medical Center andResearch Institute forMaternal and Child Health,Osaka, Japan 5)Departmentof Obstetrics and Gynecology,
University of Toyama,Toyama, Japan(1) Department ofImmunology and Parasitology,
University of Occupational andEnvironmental Health, Japan(2) Department ofOccupational Pneumology,
University of Occupational andEnvironmental Health, JapanThe relationship betweenYasumitsu Nishimura(1) Department of Hygiene,

low IL-12, IFN-γ and IL-17A (1)，Naoko Kumagai

Kawasaki Medical School,levels and low NKp46 on(1)，Megumi Maeda

Kurashiki, Japan (2) Graduate

NK cells in the culture of(2)，Hidenori Matsuzaki School of Natural Science andPBMCs upon asbestos
exposure(1)，Suni Lee (1)，Takemi Otsuki (1))Naoko Kumagai (1)，The effects of asbestos
exposure on maturation

Yasumitsu Nishimura(1)，Megumi Maeda

and maintenance of(2)，Hiroaki Hayashi

memory CTL induced by(1)，Hidenori Matsuzaki

mixed lymphocyte reactions (1)，Suni Lee (1)，Takemi Otsuki (1)Technology, Okayama
University, Okayama, Japan(1) Department of Hygiene,
Kawasaki Medical School,Okayama, Japan (2)Department of Biofunctional
Chemistry, Graduate Schoolof Natural Science andTechnology, Okayama
University, Okayama, Japan

Effects of isoflavones on
RORγt-dependent IL-17
gene expression

Hiroyuki Kojima (1)，Ryuta Muromoto (2)，Miki Takahashi (2)，Shinji Takeuchi (1)，
Tadashi Matsuda (2)(1) Hokkaido Institute of
Public Health, Sapporo, Japan(2) Graduate School of
Pharmaceutical Sciences,
Hokkaido University, Sapporo,Japan

A novel animal model ofpruritus induced bysuccessive application of
glucocorticoid to mouseskin

Katsunori Yamaura，
Ryosuke Doi，ErikoSuwa，Koichi Ueno

Department of GeriatricPharmacology andTherapeutics, Graduate Schoolof Pharmaceutical Sciences,
Chiba University, Japan

Possibility of
immunotoxicity evaluation
by ocular instillation in rats

Non-clinical Research Group,
Yoshihiro Oshita,
Nara Research andMitsunori Meda, Kouichi
Development Center, SantenKawazu
Pharmaceutical CO.,Ltd.

The role of neutrophil
infiltration in Methotrexate

Shuichi Sekine, Chiaki
Asada, Tomoko Maeda,

Department ofBiopharmaceutics, Graduate(MTX)-induced intestinal
barrier dysfunction

Naoko Kakigawa,Toshiharu Horie

School of PharmaceuticalSciences, Chiba University

Myelotoxicity of indiumoxide (2nd report) -Yuichi Miyakoshi,
Toshikazu Koiwai,

chromosomal aberration-

Hiroyuki Yanagizawa

Mechanism of ziram-

Qing Li，Maiko

induced apoptosis in human Kobayashi，Tomoyuki
T lymphocytes
KawadaSkin sensitization study by
a new qualitative structureKazuhiro Sato (1)，toxicity relationships
Yukinori Kusaka (1)，(QSTR) approach: K-step
Kohtaro Yuta (2)Yard sampling (KY)methods

Department of Public Healthand Environmental Medicine,
The Jikei University School ofMedicine, Tokyo, Japan
Department of Hygiene andPublic Health, Nippon Medical
School(1) Department ofEnvironmental Health, Schoolof Medicine, University ofFukui, Fukui, Japan， (2) In
Silico Data Ltd., Chiba, Japan

Examination ofSatoshi Saitoh，Kyouko

Molecular Genetic Research

Flowcytometry method formeasuring NK activity

Harita，Maiko
Fukushima，Youkoand Analysis
Department,Advanced Medical

Kakizaki，Sumako

Science ResearchCenter,Mitsubishi Chemical

Current Situation ofHistopathological
Examination on theImmune System Organs inStandard Toxicity Studies

Iwanaga，Kazuhiro

MedienceAbe，Kouji Nakayama

Corporation,Tokyo,Japan

Yamato Ogino, Akio
Kobayashi, Shigeo
Kawano, Kazuhiko
Taguchi, Takashi
Nagayama, KeikoMotoyama, Kazuhiro
Hosoi, Shigeru Hisada,

Non-Clinical Evaluation
Subcommittee, Drug
Evaluation Committee, Japan
Pharmaceutical Manufacturers
AssociationKazuichi Nakamura
Changes of components inKuniaki Takagi，Yukina
breast milk by stress ofIchiki，Masakuni
child care and the effects ofDegawa
thalassotherapy on them

School of PharmaceuticalScience, University ofShizuoka, Shizuoka, Japan

Poster Presentations
Chronic exposure toMegumi Maeda (1),(2)，Naoko Kumagai
chrysotile asbestos induces(2)，Hidenori Matsuzaki
IL-17 production in cultured(2)，Suni Lee (2)，human peripheral CD4 T
Yasumitsu Nishimuracells in vitro(2)，Takemi Otsuki (2)(1) Department of
Biofunctional Chemistry,
Graduate School of Natural
Science and Technology,
Okayama University, Japan(2) Department of Hygiene,
Kawasaki Medical School(1) Department of Hygiene,

Effect of Asbestos on
forkhead transcription
factor FoxO1

The enhancement of CD8

Hidenori Matsuzaki(1)，Megumi Maeda(2)，Suni Lee (1)，

Kawasaki Medical School,
Kurashiki, Japan (2)Department of Biofunctional

Naoko Kumagai (1)，Yasumitsu Nishimura

Chemistry, Graduate School of
Natural Science an d(1)，Takemi Otsuki (1)Technology, Okayama
University, JapanRyo Kobayashi，

positive cell proliferation
Tsuyoshi Nakanishi，
caused by trichloroethylene Hisamitsu Nagase

The effects of fluoride on

Takamasa Kido (1,2)，
Masashi Tsunoda (2)，mRNA expressions ofcytokines in the splenic

Chiemi Sugaya (2)，Ryutaro Ikeuchi (1,2)，

macrophages in ICGN miceand ICR mice via drinking

Yukio Kodama (4)，Ryouko Konishi (4)，waterKazuyoshi Itai (3)，
Yoshiharu Aizawa (2)Gifu PharmaceuticalUniversity, Gifu, Japan(1) Graduate School ofMedical Sciences, Kiasato
University of Sagamihara,Kanagawa Japan (2)Preventive Medicine andPublic Health, Kiasato
University School of Medicine(3) Preventive Medicine andPublic Health, Iwate Medecal
University (4) National
Institute of Health Sciences

Prior oral exposure toenvironmental
immunosuppressive agents
aggravates mite allergeninduced atopic dermatitislike immunoreaction

Tomoki Fukuyama，)Toxicology Division, The
Yukari Tajima，Koichi
Institute of Environmental
Hayashi，Hideo Ueda，
Toxicology, Ibaraki, Japan
Tadashi KosakaThe immunobiological

Takemi Otsuki (1)，effects of negativelycharged air particle

Kazuaki Takahashi (2)， Med. Sch., Kurashiki, JapanKouki Manabe (3)，(2) Comprehensive Housing
Muneo Kotani (3)，(1)

Dept. Hyg., Kawasaki

R&D Inst., Sekisui House,dominant indoor air

Megumi Maeda (4)，Ltd.,Kizugawa, Japan (3)circumstance

Naoko Kumagai (1)，Hidenori Matsuzaki

Dept. Environ. Enhancement,
Sekisui House, Ltd., Osaka,(1)，Suni Lee (1)，Yasumitsu Nishimura(1)

Japan (4) Div. Bioscience,
Dept. Biofunct. Chem., Grad.
Sch. Nat. Sci. Technol.,Okayama Univ., Okayama,
Japan(1)Masashi Tsunoda (1)，The effects of TBT on theTakamasa Kido (1,2)，
productions of cytokines by
Ryutaro Ikeuchi (1,2)，
splenocytes from F1 rats by
Chiemi Sugaya (1)，the exposure from fetus toHiroshi Katagiri (3)，developing stages
Yoshiharu Aizawa (1)Department ofPreventive Medicine, Kitasato
University School of Medicine,
Sagamihara, Japan (2)Kitasato University Graduate
School of Medical Sciences,
Sagamihara, Japan (3)Department of Public Health,
Kitasato University School ofAllied Health Sciences,
Sagamihara, Japan

Hideki Matsuoka (1)，Hiroshi Akiyama (1)，Kozue Sakata (1)，Rika(1) National Institute of
Health Sciences, Tokyo,Japan (2) ResearchMechanism of the inhibition Nakamura (1)，Shingoof the oral sensitization by Takahashi (2)，Koichi

Institute, Kagome Co., Ltd.,
Nasushiobara-shi, Japan (3)β-carotene intake

Aizawa (2)，Takahiro
Inakuma (2)，Mamoru

Department of Applied
Biological Chemistry , The

Tostuka (3)，ReikoTeshima (1)University of Tokyo, Tokyo,JapanA New In Vitro Assay
System for Assessment ofTerumi Katori (1),
Tomoko Shindo (1),(1) Hatano ResearchInstitute, Food and Drug

Food Allergenicity : (3)Coupling with In Vitro

Motoyasu Ohsawa (1),Kohichi Kojima (1),

Safety Center, Hadano, Japan(2) National Institute ofProtein Digestion Process

Reiko Teshima (2)Health Sciences, Tokyo, Japan

Tomoko Shindo (1),Terumi Katori (1),(1) Hatano ResearchInstitute, Food and Drug
Safety Center, Hadano, (2)Yukiko Kanazawa (2),Kohichi Kojima (1),Pharmaceuticals and Medical
Devices Agency, Tokyo, (3)Reiko Teshima (3)National Institute of HealthSciences, Tokyo, Japan

Murine Oral Food Allergy
Model: Alteration ofProductive IgA Contents inIntestine

学生・若手セッション
Effects of histamine H (4)receptor antagonist

Eriko Suwa, Katsunori

Department of GeriatricPharmacology andJNJ7777 (1) (2)0 on themouse model of atopic

Yamaura and Koichi
Ueno

Therapeutics, Graduate Schoolof Pharmaceutical Sciences,dermatitis

Chiba University
Kenta Watanabe (1),

Effect of Acrolein on
Macrophages

Itsuko Ishii (1), Yuki
Nakazato (1), Kazuei
Igarashi (1), (3),
Mitsukazu Kitada (2)(1))Graduate School of
Pharmaceutical Sciences,
Chiba University, (2))Divisionof pharmacy, Chiba University
Hospital, (3))Amine Pharma
Research InstituteAllergenicity test of
Arabidopsis DREB (1)A-

Rika Nakamura (1)，Rie (1))Division of Novel Foods
Satoh (1), (2)，Ryosuke and Immunochemistry,

Transgenic Potato Using

Nakamura (1)，National Institute of HealthImmunoproteomic andTakayoshi ShimazakiSciences, Tokyo, Japan(2)D-DIGE Analysis(3)，Mie Kasuga (4)，Kazuko Shinozaki (4)，(2))National Food ResearchInstitute, Tsukuba, Japan

Akira Kikuchi (3)，Kazuo Watanabe (3)，
Reiko Teshima (1)(3))Gene Research Center,
Graduate School of Life andEnvironmental Sciences,
University of Tsukuba,
Tsukuba, Japan (4))
Biological Resources Division,Japan International ResearchCenter for AgriculturalSciences (JIRCAS), Tsukuba,Japan

Ayano Ishiwatari (1),Allergenicity of heatprocessed egg white
revealed by cell-basedassay(1))The Division of NovelFoods and Immunochemistry,

National Institute of Health(2)，Ryosuke Nakamura
Sciences, Tokyo, Japan(1)，Masakazu Higuchi(2))Graduate School of Food(1)，Yoshimi Uchida
Science, Kyoritsu Women's(1)，Rika Nakamura
University, Tokyo, Japan(1)，Hiroshi Kawakami(3))Department Pediatrics,(2)，Atsuo Urisu (3)，The Second Teaching Hospital
Reiko Teshima (1)of Fujita Health University,
Aichi, Japan

Effects of exposure ofHiromasa Tsuyama，

human NK cells to arsenite

Daigo Sumi，Tomokoon gene expression end

Ogawa，Seiichiro

cytotoxic activit

HimenoFaculty of PharmaceuticalSciences, Tokushima BunriUniversity, Tokushima, Japan

Hirofumi Ogino (1)，KeiOkayama (1)，MihoKitayama (1)，Iku
Yabuta (1)，Syogo
Asakura (1)，Yusuke(1) Faculty of Pharmaceutical

Enhancing effects of oral-KikuchiI (1)，Chisa
Betto (1)，Koichi

Sciences, Setsunan University,Hirakata, Osaka, Japan (2)administered oxidized olive

Murano (1)，Ryo

Faculty of Science &oil on mouse skin allergy

Yonemitu (1)，Fumitoshi Sakazaki

Engineering, Setsunan
University, Neyagawa, Osaka,(1)，Tomohiro Arakawa Japan(1)，Tomofumi Okuno(1)，KatsuhikoNakamuro (2)，HitoshiUeno (1)Luncheon Seminars
Principal Scientist，CharlesBiomarkers of inflammation Simon LavalléeRiver Laboratories PreclinicalServices Montreal Inc, Canada

Immunogenicity ofbiotherapeutics;
Christopher Kirton
contributing factors, impactand mitigation

Huntingdon Life Sciences Ltd.,UK