シンポジウム

第 1 日目12 月 3 日（火）シンポジウムシンポジウム第1日目12月3日（火）1AS-01 Room 1 (Fukuoka International Congress Center 5F 501)

9:00-11:30【E】

第１日目

Crossroad of Chemical and RNA Biology
Organizers：‌Shinichi Nakagawa (Hokkaido University)
Masatoshi Hagiwara (Kyoto University)

Introduction 【9:00】

Shinichi Nakagawa（Hokkaido University）

1AS-01-1 Chemical approach to elucidate the regulatory mechanisms of snRNP biogenesis
2

1,2

1,2 1

【9:01】
2

Saki Ohazama , Shinichi Nakagawa , Hiroshi Maita （ Fac. of Pharm. Sci., Hokkaido Univ., Grad. Sch. of Life Sci.,
Hokkaido Univ.）

1AS-01-2 【9:19】
Identification of novel molecular glue that induces selective degradation of splicing factor CAPER-alpha
via CUL4-DCAF15 ubiquitin ligase
Taisuke Uehara1, Yukinori Minoshima1, Koji Sagane1, Naoko Sugi1, Kaoru Mitsuhashi1, Noboru Yamamoto1, Hiroshi
Kamiyama1, Kentaro Takahashi1, Yoshihiko Kotake1, Mai Uesugi1, Akira Yokoi1, Atsushi Inoue1, Miyuki Mabuchi2,
1 1
Akito Tanaka2, Takashi Owa（
Eisai Co., Ltd., 2School of Pharmacy, Hyogo University of Health Science）

1AS-01-3 【9:44】

A novel translational buffering system that links splicing and cancer

Minoru Yoshida1,2（1RIKEN CSRS, 2Dept. of Biotechnol., CRIIM, Univ. of Tokyo）

1AS-01-4 【10:09】Using molecular glues to target gene expression

Ting Han（National Institute of Biological Sciences）

1AS-01-5 【10:34】mRNA processing and disease

Gideon Dreyfuss（Dept. Biochemistry and Biophysics, Howard Hughes Medical Institute, School of Medicine, Univ.
of Pennsylvania）

1AS-01-6 
Drug Discovery for Genetic Diseases Caused by Aberrant mRNA Splicing【11:04】Masatoshi Hagiwara（Grad. Sch. of Med., Kyoto Univ.）

Conclusion 【11:29】Masatoshi Hagiwara（Kyoto University）

1AS-11 Room 11 (Fukuoka International Congress Center 3F Main Hall)

9:00-11:30【E】

Neurogenesis ~from developmental to adult stages~
Organizers：‌Kinichi Nakashima (Kyushu University)
Sebastian Jessberger (University of Zurich)

Introduction 【9:00】

Kinichi Nakashima（Kyushu University）

1AS-11-1 【9:02】
Gene expression dynamics regulating the timing of neuronal differentiation during mammalian neuraldevelopment
Hiromi Shimojo, Ryoichiro Kageyama（Inst. for Frontier Life and Medical Sciences, Kyoto Univ.）

1AS-11-2 
How has the brain expanded and acquired complexity in the mammalian evolution?

【9:32】

Yuji Tsunekawa, Taeko Suetsugu, Ikumi Fujita, Quan Wu, Atsunori Shitamukai, Ayaka Omori, Osamu Nishimura,
Shigehiro Kuraku, Fumio Matsuzaki（RIKEN BDR）

94

第 42 回日本分子生物学会年会

シンポジウム

第 1 日目12 月 3 日（火）Controlling the positioning of new neurons for functional regeneration in the post-stroke brain【10:02】

Naoko Kaneko1, Kazunobu Sawamoto1,2（1Department of Developmental and Regenerative Biology, Nagoya City
University Graduate School of Medical Sciences, 2Division of Neural Development and Regeneration, National
Institute for Physiological Sciences）

Artificial generation of new neurons in adult central nervous systems【10:32】

Kinichi Nakashima（Dep. Stem Cel Biol. Med., Grad. Sch. Med. Sci., Kyushu Univ.）

1AS-11-5 
Elucidating the molecular and cellular dynamics of neurogenesis【10:58】Sebastian Jessberger（Univ. of Zurich）

Conclusion 

Sebastian Jessberger（University of Zurich）

1PS-01 Room 1 (Fukuoka International Congress Center 5F 501)
Morphostasis: the crossroads between developmental and disease biology【11:28】15:45-18:15【E】

Organizers：‌Erina Kuranaga (Tohoku University)
Tohru Ishitani (Gunma University / Osaka University)

Introduction 【15:45】

1PS-01-1 【15:47】

Tohru Ishitani（Gunma University / Osaka University）

Genetic dissection of epithelial wound repair and remodeling via cell-cell communication
Tatsushi Igaki（Lab. of Genetics, Grad. Sch. of Biostudies, Kyoto Univ. ）1PS-01-2 
Mechanical Feedbacks in Morphogenetic Robustness【16:11】Fengzhu Xiong（Gurdon Institute, University of Cambridge）

1PS-01-3 
Defective cell sensing and elimination system utilizing Wnt morphogen-gradient【16:35】

Yuki Akieda1, Shohei Ogamino2, Tohru Ishitani1,2（1Homeostatic Reg., RIMD, Osaka Univ., 2Integ. Signal. Sys., IMCR,
Gunma Univ.）

1PS-01-4 
Environmental Stress and Myocardial Regeneration【16:59】Wataru Kimura（RIKEN BDR）

1PS-01-5 
Epithelial stem cells in tissue regeneration and aging【17:23】

Aiko Sada（TARA., Univ. of Tsukuba）

1PS-01-6 
Organoid-based analysis of human kidney development and disease【17:47】

Ryuichi Nishinakamura（Int. Mol. Embryol. Genet., Kumamoto Univ.）

Conclusion 

Erina Kuranaga（Tohoku University）

1PS-11 Room 11 (Fukuoka International Congress Center 3F Main Hall)
Molecular Biology of CRISPR ~Origin, Function, Structure and Application ~【18:11】
15:45-18:15【E】

Organizer：‌Yoshizumi Ishino (Kyushu University)

1PS-11-1 History of CRISPR/Cas, beginning from encounter with a mysterious repeated sequence【15:45】

Yoshizumi Ishino（Dept. Biosci.Biotech., Grad.Sch.of Bioresouce & Bioenviron. Sci., Kyushu Univ.）

The 42nd Annual Meeting of the Molecular Biology Society of Japan

95

第１日目

1AS-11-4 

シンポジウム1AS-11-3 シンポジウム

第 1 日目12 月 3 日（火）シンポジウム1PS-11-2 【15:58】Diversity, evolution, and exaptation of CRISPR-Cas systems
Eugene Koonin（Nath. Center Biotechnol. Info., NIH, USA）

1PS-11-3 

第１日目

Molecular mechanisms of antiviral defence by archaeal CRISPR-Cmr systems【16:32】

Qunxin She1,2（1Micro. Tech. Inst., Shandong Univ., 2Archaea Centre, Dept. of Biol., Univ. of Copenhagen）

1PS-11-4 
Structure-based molecular engineering of CRISPR-Cas9【17:06】Hiroshi Nishimasu（The University of Tokyo）

1PS-11-5 
Expanding the diversity of the Type V CRISPR repertoire【17:40】David Scott1, Pratyusha Hunnewell1, Lauren Alfonse1, Jason Carte1, Elise Keston-Smith1, Shanmugapriya
Sothiselvam1, Anthony Garrity1, Shaorong Chong1, Kira Makarova2, Eugene Koonin2, David Cheng1, Winston
1 1
Yan（
Arbor Biotechnologies, 2National Center for Biotechnology Information, National Library of Medicine, National
Institutes of Health）

Conclusion 

Yoshizumi Ishino（Kyushu University）

96【18:14】

第 42 回日本分子生物学会年会

シンポジウム

第 2 日目12 月 4 日（水）第2日目12月4日（水）2AS-01 Room 1 (Fukuoka International Congress Center 5F 501)

9:00-11:30【E】

Frontiers of in-cell protein sciences
Organizers：‌Kenji Inaba (Tohoku University)
Yutaka Ito (Tokyo Metropolitan University)

2AS-01-1 Kenji Inaba（Tohoku University）

2AS-01-2 【9:25】

Phase Separation for Compartmentalization: Mechanism, Function and Pathology
Tanja Mittag（Dept. of Structural Biology, St. Jude Children's Research Hospital）

2AS-01-3 
Stress– and ubiquitylation–dependent phase separation of the proteasome
1

1

2

2

【9:50】
2

Sayaka Yasuda , Hikaru Tsuchiya , Qiang Guo , Wolfgang Baumeister , Ruben Fernandez-Busnadiego , Keiji Tanaka1,
1 1
Yasushi Saeki（Lab. of Prot. Metabo., TMIMS, 2Dept. of Mol. Struct. Biol., MPI of Biochem.）

2AS-01-4 【10:15】Interplay between autophagy-related liquid droplets and membranes
Nobuo N. Noda（Lab. of Struct. Biol., Inst. Microbial Chem.）

2AS-01-5 
Molecular Dynamics and Interaction of Protein-Ligand Binding in Crowded Cellular Environments【10:40】

Yuji Sugita（RIKEN CPR）

2AS-01-6 【11:05】

Solution NMR approaches to 3D structure determination of proteins in living eukaryotic cells
Yutaka Ito, Teppei Ikeya（Dept. of Chem., Tokyo Metropolitan Univ.）

2AS-11 Room 11 (Fukuoka International Congress Center 3F Main Hall)
Molecular mechanisms governing cellular pluripotency

9:00-11:30【E】

Organizer：‌Hitoshi Niwa (Kumamoto University)

Introduction 

Hitoshi Niwa（Kumamoto University）【9:00】

2AS-11-1 【9:02】
Overlapping function of Klf family members and Tbx3 prevents suicide of mouse ES cells by activation of
Foxd3
Hitoshi Niwa（IMEG, Kumamoto Univ.）

2AS-11-2 
Haploid mouse embryonic stem cells as a tool for discovery of new regulators of X chromosome
inactivation【9:22】

Anton Wutz, Asun Monfort, Andreas Postlmayr（D-BIOL, Swiss Federal Institute of Technology）

2AS-11-3 【9:47】
DNA hypomethylated female mouse ES cells as a useful tool to identify de novo DNA methylation activity
by Dnmt3a and Dnmt3b
Yasuhiro Yamada（IMSUT）

2AS-11-4 
Systems Biology of Gene Regulation in Mouse Pluripotency【10:12】

Henk Stunnenberg, Yaser Atalsi, Wout Megchelenbrink, Tianran Peng, Menno ter Huurne（Molecular Biology,
Radboud University）

The 42nd Annual Meeting of the Molecular Biology Society of Japan97

シンポジウム 第２日目

【9:00】
Novel protein quality control system cooperated by zinc ions and ERp44 in the early secretory pathwayシンポジウム

第 2 日目12 月 4 日（水）2AS-11-5 【10:37】
Zscan4 and maintenance of genome integrity in pluripotent stem cells, preimplantation embryos, andgerm cells
Minoru Ko1, Tomohiko Akiyama1, Kei-ichiro Ishiguro2, Shigeru Ko1, Nana Chikazawa-Nohtomi1, Yuhki Nakatake1,
1 1
Saeko Sato（
Systems Med., Sch. of Med., Keio Univ., 2Inst. of Mol. Embryology & Genet.）

2AS-11-6 【11:02】Formative Pluripotency

Masaki Kinoshita, Austin Smith（Wellcome-MRC Cambridge Stem Cell Institute, Univ. of Cambridge）

シンポジウム 第２日目

Conclusion 【11:27】

Austin Smith（Wellcome-MRC Cambridge Stem Cell Institute, Univ. of Cambridge）

2PS-01 Room 1 (Fukuoka International Congress Center 5F 501)

15:45-18:15【E】
Co-hosted by: Plant-Structure Optimization Strategy, Grant-in-Aid for Scientific Research on Innovative Areas
Functions and Mechanisms of Force in Animal and Plant Live
Organizers：‌Miyo T. Morita (National Institute for Basic Biology)
Masatsugu Toyota (Saitama University)

Introduction 【15:45】

2PS-01-1 【15:48】

Miyo Terao Morita（National Institute for Basic Biology）

Molecular and biophysical mechanisms of substrate rigidity sensing that determines cell fate

2 1
Masahiro Sokabe1, Takeshi Kobayashi（
Mechanobiology Lab., Nagoya Univ., Grad. Sch. of Med. , 2Dept. of Physiol.,
Nagoya Univ., Grad. Sch. of Med.）

2PS-01-2 
Forces and their Feedback in Epithelial Tissue Morphogenesis: Multiscale Biomechanics Approach【16:18】

Taiji Adachi（Lab. of Biomechanics, Inst. for Front. Life & Med. Sci., Kyoto Univ.）

2PS-01-3 【16:48】Suboptimal mechanical signals add robustness to plant development
Olivier Hamant（ENS Lyon）

2PS-01-4 【17:18】Sensing mechanism of directional cue of gravity in plant gravitropism

2 1
Miyo Terao Morita1, Moritaka Nakamura1, Takeshi Nishimura1, Masatsugu Toyota（
NIBB, 2Grad. Sch. of Sci. &Eng., Saitama Univ.）

2PS-01-5 
Influence of cell wall composition toward mechanical property during gravitropism of Arabidopsis
inflorescence stems【17:43】Misato Ohtani1,2, Norihiro Kanda1, Takuya Tokumoto1, Lorenz Gerber3, Satoru Tsugawa1, Moritaka Nakamura4, Miyo
1 1
T. Morita4, Taku Demura（Div. of Biol. Sci., NAIST, 2Grad. Sch. of Front. Sci., Univ. of Tokyo, 3Genome Inst. ofSingapore, 4Div. of Plant Environ. Responses, NIBB）

Conclusion 【18:12】Masatsugu Toyota（Saitama University）

2PS-11 Room 11 (Fukuoka International Congress Center 3F Main Hall)

15:45-18:15【E】

Unbiased life sciences by data-driven approaches
Organizers：‌Tohru Natsume (AIST)
Keiichi Nakayama (Kyushu University)

2PS-11-1 
Decoding the cellular functions by AI with large-scale collection of epigenetic information【15:45】Jun Sese（Humanome Lab.）98

第 42 回日本分子生物学会年会

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第 2 日目12 月 4 日（水）2PS-11-2 Transforming the future with precision medicine by enabling high-throughput protein biomarker
discovery and validation using multiplex Proximity Extension Assay【16:10】Ida Grundberg（Olink Proteomics, Inc.）

2PS-11-3 
Unraveling Oxidative Stress Resistance of the Proteome【16:35】

2PS-11-4 【17:00】
The Leading-edge Applications of Mass Spectrometry in the Drug Discovery & Diagnosis for Precision
Medicine ~ Integration of comprehensive Omics analysis into Precision Medicine
Taka-Aki Sato（R&D Center for Precision Medicine, Tsukuba University）

2PS-11-5 
Machine learning uncovers novel aspects in healthcare and life science【17:25】

Hideyuki Shimizu, Keiichi I. Nakayama（Div. of Mol. Cell. Biol., Med. Inst. of Bioregulation, Kyushu Univ.）

2PS-11-6 
Robotic Research Process Automation【17:50】Koichi Takahashi1,2（1RIKEN, 2Keio University SFC）

The 42nd Annual Meeting of the Molecular Biology Society of Japan99

シンポジウム 第２日目

Roger L. Chang1,2, Matthew C. Robinson1, Joel W. Sher1, Zhanwen Li3, Yujia A. Chan1,2, Ashton R. Omdahl1,
5 1
Ruddy Wattiez4, Adam Godzik3, Sabine Matallana-Surget（
Dept. of Sys. Bio., Harvard Med. School, 2Wyss Inst. for
Biologically Inspired Engineering, Harvard Univ., 3Div. of Biomed. Sci., Univ. of California Riverside Sch. of Med., 4Dept.
of Proteomics and Microbio., Res. Inst. for Biosci., Univ. of Mons, 5Div. of Bio. and Env. Sci., Fac. of Nat. Sci., Univ. ofStirling）

シンポジウム

第 3 日目12 月 5 日（木）第3日目12月5日（木）3AS-01 Room 1 (Fukuoka International Congress Center 5F 501)

9:00-11:30【E】

Metabolic dynamics for cancer cell plasticity and fate decision
Organizers：‌Akira Suzuki (Kobe University)
Atsushi Hirao (Kanazawa University)

Introduction 【9:00】

3AS-01-1 【9:02】

Akira Suzuki（Kobe University）

Critical regulation of metabolites for hematopoietic homeostasis and leukemogenesis
Atsushi Hirao（Div. Mol. Gen., CRI, Kanazawa Univ.）

3AS-01-2 【9:27】

Metabolic vulnerability in senescent cells

Makoto Nakanishi, Yoshikazu Johmura（Div. of Cancer Cell Biol., Inst. of Med. Sci., Univ. of Tokyo）

3AS-01-3 
シンポジウム 第３日目

Metabolic adaptation of cancer cells to tumor microenvironments for tumor progression【9:52】

Tsuyoshi Osawa（Div. Nutriomics Onc., RCAST, Univ. of Tokyo）

3AS-01-4 【10:12】Next-generation proteomics unveils a global landscape of cancer metabolism: Discovery of the "second"
Warburg effectKeiichi Nakayama（Dept. Mol. Cell. Biol., Med. Inst. Bioreg., Kyushu Univ.）

3AS-01-5 【10:42】

Metabolic Adaptation in Malignancies

Tak Wah Mak1,2（1Princess Margaret Cancer Centre, 2University of Hong Kong）

Conclusion 【11:27】

Atsushi Hirao（Kanazawa University）

3AS-11 Room 11 (Fukuoka International Congress Center 3F Main Hall)

9:00-11:30【E】

Immune system in health and disease
Organizers：‌Taro Kawai (Nara Institute of Science and Technology)
Reiko Shinkura (The University of Tokyo)

3AS-11-1 【9:00】

Intestinal IgA as a modulator of gut microbiota

Reiko Shinkura（Institute for Quantitative Biosciences, The University of Tokyo）

3AS-11-2 
Pairwise interactions predict complex combinatorics in pathogen sensing【9:30】

Nicolas Chevrier（Pritzker School of Molecular Engineering, Univ. of Chicago）

3AS-11-3 
Endoribonuclease Regnase-1 controls inflammation and immune responses【10:00】

Shizuo Akira（Lab. of Host Defense, IFReC., Osaka Univ.）

3AS-11-4 【10:30】Role of gut microbiota in intestinal pathogen colonization

Yun-Gi Kim（Res. Cent. for Drug Discov., Facul. of Pharm., Keio Univ.）

3AS-11-5 
Local expansion of CD8+ T cells by tissue resident macrophages in the lung

【11:00】Taro Kawai, Takumi Kawasaki（Lab. of Mol. Immunobiol., Div. of Bio. Sci., Nara Inst. of Sci. Tech）

100

第 42 回日本分子生物学会年会

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第 3 日目12 月 5 日（木）3AS-12+13 Room 12 + 13 (Fukuoka International Congress Center 2F 201+202)

9:00-11:30【E】
Understanding biodynamics by the trinity of measuring, mathematical, and controlling techniques
Organizers：‌Ryoichiro Kageyama (Kyoto University)
Atsushi Mochizuki (Kyoto University)

Introduction 【9:00】

3AS-12+13-1 【9:03】

Atsushi Mochizuki（Kyoto University）

Controlling cell fate specification system based on network structure

Atsushi Mochizuki1,2, Kenji Kobayashi3, Kazuki Maeda4, Miki Tokuoka5, Yutaka Satou2,5（1Inst. for Front. Life &Med. Sci., Kyoto U., 2CREST, JST, 3Marine Biol. Lab., Grad. Sch. of Integ. Sci. for Life, Hiroshima Univ., 4Univ. of
Fukuchiyama, 5Dept. of Zool., Grad. Sch. of Sci., Kyoto Univ.）

3AS-12+13-2 
Quantification and manipulation of cell signaling by live cell imaging【9:25】

Kazuhiro Aoki（ExCELLS/NIBB, NINS）

3AS-12+13-3 【9:50】

1 1
Daisuke Imoto1, Nen Saito2, Satoshi Sawai（Grad. Sch. of Arts. Sci., Univ. of Tokyo, 2Grad. Sch. of Sci., Univ. ofTokyo）

3AS-12+13-4 Model-based understanding of cell proliferation【10:15】

Mariko Okada（Institute for Protein Research, Osaka University）

3AS-12+13-5 Collective cell rearrangements and cell flows in dynamic tissues【10:40】Frank Jülicher（Max Planck Institute for the Physics of Complex Systems）

3AS-12+13-6 
Mechanism of synchronized Hes7 oscillations in the somite segmentation clock【11:05】

Ryoichiro Kageyama1,2（1Inst. Front. Life Med. Sci., 2iCeMS）

Conclusion 

Ryoichiro Kageyama（Kyoto University）【11:27】

3PS-01 Room 1 (Fukuoka International Congress Center 5F 501)

15:45-18:15【E】
Co-hosted by: JST CREST “Innovative Technology Platforms for Integrated Single Cell Analysis”
Cutting edge of technical innovations in integrated single cell analysis
Organizers：‌Piero Carninci (RIKEN)
Takeshi Bamba (Kyushu University)

3PS-01-1 
Functional genomics moving into single-cell analysis【15:45】

Piero Carninci（RIKEN Center for Integrative Medical Sciences）

3PS-01-2 
Three challenges in single cell workflows【16:10】Alistair Forrest（Harry Perkins Institute of Medical Research）

3PS-01-3 
Development of chromatin integration labeling technology for single cell multiomics【16:35】

Yasuyuki Ohkawa（Div. of Transcriptomics, MIB, Kyushu Univ.）

3PS-01-4 
Automated single-cell and signle-molecule imaging analysis【17:00】Masahiro Ueda1,2（1Graduate School of Frontier Biosciences, Osaka University, 2 Center for Biosystems Dynamics
Research (BDR), RIKEN）

The 42nd Annual Meeting of the Molecular Biology Society of Japan101

シンポジウム 第３日目

Mathmatical model-based analysis of morphodynamic spectrum of fast migrating cellsシンポジウム

第 3 日目12 月 5 日（木）3PS-01-5 【17:25】Comprehensive Integration of Single Cell Protein Analysis by Nanofluidic Device and Photothermal Optical
Phase Sift Detection
Takehiko Kitamori（School of Engineering, The Univeristy of Tokyo ）3PS-01-6 
Development of single-cell molecular phenotyping technologies based on mass spectrometry【17:50】

Takeshi Bamba（Med. Inst. Bioreg., Kyushu Univ.）

3PS-11 Room 11 (Fukuoka International Congress Center 3F Main Hall)

15:45-18:15【E】

Molecular basis of phenotypic variation regulated by epigenome
Organizers：‌Mitsuyoshi Nakao (Kumamoto University)
Takeshi Inagaki (Gunma University)

3PS-11-1 【15:45】A Chromatin Conformation-Dependent Regulation of Adipocyte Characteristics by JMJD1A
Takeshi Inagaki1, Juro Sakai2,3（1Gunma Univ., 2The University of Tokyo, 3Tohoku University）

シンポジウム 第３日目

3PS-11-2 【16:10】EPIGENETIC UNDERPINNINGS OF METABOLIC DISEASE HETEROGENEITY
J. Andrew Pospisilik（Van Andel Research Institute）

3PS-11-3 【16:45】Function of HP1 in H3K9 methylation dynamics

Makoto Tachibana, Ryo Maeda（FBS, Osaka Univ.）

3PS-11-4 【17:15】Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses
Tiffany Horng（ShanghaiTech University）

3PS-11-5 【17:50】Regulation of macrophage and dendritic cell subsets by lipid mediator and epigenome

1 1
Tomoaki Koga1, Fumiyuki Sasaki2, Takehiko Yokomizo2, Mitsuyoshi Nakao（
Dept. of Med. Cell Biol., Inst. of Mol.
Emb. Genet., Kumamoto Univ., 2Dept. Biochem., Juntendo Grad. Sch. of Med.）

3PS-12+13 Room 12 + 13 (Fukuoka International Congress Center 2F 201+202)
Decoding informational processing in the brain that underlies behavioral regulation

15:45-18:15【E】

Organizers：‌Yuichi  Iino (The University of Tokyo)
Takeshi Ishihara (Kyushu University)

3PS-12+13-1 Conservation and variability in the neural sub-networks in the whole nervous system of C. elegans【15:45】

Yuichi Iino1, Yu Toyoshima1, Hirofumi Sato1, Stephen Wu2, Yuishi Iwasaki3, Manami Kanamori1, Moon-Sun Jang1,
Suzu Oe4, Yoko Murakami4, Sayuri Kuge4, Osamu Hirose5, Terumasa Tokunaga6, Takayuki Teramoto4, Ryo Yoshida2,
4 1
Takeshi Ishihara（
Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 2Inst. of Stat. Math., Res. Org. of Info. andSys., 3Dept. of Intel. Sys. Eng., Ibaraki Uiv., 4Dep. Biol., Facl. Sci., Kyushu Univ., 5Facl. of Electr. and Comput. Eng.,
Inst. of Sci. and Eng., Kanazawa Univ., 6Dept. of Sys. Design and Info., Facult. of Comput. Sci. and Sys. Eng., Kyushu
Inst. of Tech.）

3PS-12+13-2 
How are neural and metabolic networks coordinated to shape behavior?

【16:12】

Thomas R. Clandinin（Department of Neurobiology, Stanford University）

3PS-12+13-3 
in-vivo imaging of the telencephalic neural activities in the closed-loop virtual reality environment
revealed active inference in decision making【16:54】

Hitoshi Okamoto（RIKEN Center for Brain Science）

102

第 42 回日本分子生物学会年会

シンポジウム

第 3 日目12 月 5 日（木）3PS-12+13-4 Motor information flow between the mouse motor cortices【17:21】

Masanori Matsuzaki, Shin-ichiro Terada（Dept. of Physiol., Grad. Sch. of Med., Univ. of Tokyo）

3PS-12+13-5 Orchestrated ensemble activities constitute a hippocampal memory engram【17:48】

Kaoru Inokuchi（Grad. Sch. of Med. Pharma., Univ. of Toyama）

シンポジウム 第３日目

The 42nd Annual Meeting of the Molecular Biology Society of Japan103

シンポジウム

第 4 日目12 月 6 日（金）第4日目12月6日（金）
4S-01

13:00-15:30【E】

Room 1 (Fukuoka International Congress Center 5F 501)
Augmented Cell Engineering
Organizers：‌Takanori Takebe (Tokyo Medical and Dental University)
Nozomu Yachie (The University of Tokyo)

Introduction 【13:00】4S-01-1 【13:03】

Nozomu Yachie（The University of Tokyo）

Designer's Organoids By Narrative Engineering
Takanori Takebe1,2（1TMDU, 2CCHMC）

4S-01-2 【13:27】Single-cell genomic analysis of human organoid development

Gray Camp（Institute of Molecular and Clinical Ophthalmology Basel）

4S-01-3 【13:51】

Generating a non-linear phenotype in non-polarized, artificial cells
Takanari Inoue（Johns Hopkins University）

4S-01-4 【14:15】

DNA Recording Biology

Nozomu Yachie（RCAST, Univ. of Tokyo）

4S-01-5 
A roadmap for how human pluripotent stem cells develop into diverse tissue progenitors【14:39】

シンポジウム 第４日目

Kyle Loh（Institute for Stem Cell Biology & Regenerative Medicine, Department of Developmental Biology,
Stanford University School of Medicine）

4S-01-6 
Human Time vs. Mouse Time with in vitro Recapitulated Systems【15:03】

Miki Ebisuya（EMBL Barcelona）

Conclusion 

Takanori Takebe（Tokyo Medical and Dental University）【15:27】

4S-11

Room 11 (Fukuoka International Congress Center 3F Main Hall)
13:00-15:30【E】
Co-hosted by: Grant-in-Aid for Scientific Research on Innovative Areas “Program of totipotency”, “Ensuring
integrity in gametogenesis”
Robustness of germline lineage
Organizers：‌Katsuhiko Hayashi (Kyushu University)
Masahito Ikawa (Osaka University)

Introduction 【13:00】4S-11-1 【13:02】

Katsuhiko Hayashi（Kyushu University）

Study of fertilization through genome-edited mice

Masahito Ikawa1,2（1RIMD, Osaka University, 2IMSUT, Univ. of Tokyo）

4S-11-2 What do we learn from somatic cell nuclear transfer (SCNT)?

【13:25】

Atsuo Ogura, Shogo Matoba, Kimiko Inoue（RIKEN BRC）

4S-11-3 【13:50】
The transcription factor complex NF-Y controls zygotic genome activation and early mouse development

Antoine H.F.M. Peters, Deepankar Singh, Evgeniy A. Ozonov, Yumiko K Kawamura, Sebastien A. Smallwood（Friedrich Miescher Institute for Biomedical Research）

104

第 42 回日本分子生物学会年会

シンポジウム

第 4 日目12 月 6 日（金）4S-11-4 
Mechanism and Reconstitution In Vitro of Human Germ Cell Development【14:15】Mitinori Saitou1,2,3（1ASHBi, Kyoto Univ., 2Dept. of Anat. Cell Biol., Grad. Sch. of Med., Kyoto Univ., 3CiRA, Kyoto
Univ.）

4S-11-5 
A mechanism underlying sustainable oocyte production in mouse germ line

【14:40】Katsuhiko Hayashi, Go Nagamatsu, Nobuhiko Hamazaki, Takashi Yoshino（Dept. of Stem Cell Biol. Med., Grad.
Sch. of Med. Sci., Kyushu Univ. ）4S-11-6 
Robust spermatogenesis is supported by random behavior and simple regulation of stem cells【15:03】

Shosei Yoshida（Natl. Inst. Basic Biol.）

Conclusion 【15:28】The 42nd Annual Meeting of the Molecular Biology Society of Japan105

Masahito Ikawa（Osaka University）

シンポジウム 第４日目