Publications 2004~2020
Nucleic Acid Medicine- - - - - - - - - - 2020 年 - - - - - - - - - - 實吉尚郎、小野晶
プロオリゴ型核酸医薬を志向した保護基の開発研究
有機合成化学協会誌、2020, 78 (9), 886-893.（総説）
https://doi.org/10.5059/yukigoseikyokaishi.78.886
Hisao Saneyoshi, Kodai Nakamura, Kazuma
Terasawa, Akira Ono
Development of Bioreduction Labile Protecting
Groups for the 2’-Hydroxyl Group of RNA
Organic Letters, 2020, 22, 15, 6006–6009.
https://doi.org/10.1021/acs.orglett.0c02086(Publication Date: July 14, 2020)

Hisao Saneyoshi, Yuta Yamamoto, Takayuki Ohta, Shoji Akai, Akira Ono
Thiol-responsive pro-fluorophore labeling: Synthesis of a pro-fluorescent labeledoligonucleotide for monitoring cellular uptake
Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127222.
https://doi.org/10.1016/j.bmcl.2020.127222(Volume 30, Issue 13, 1 July2020, 127222)- - - - - - - - - - 2019 年 - - - - - - - - - - Hisao Saneyoshi, Takayuki Ohta, Yuki Hiyoshi, T. Saneyoshi, Akira Ono“Design, synthesis and cellular uptake of oligonucleotides modified with glutathione-labile
protecting groups”Org. Lett., 2019, 21, 862−866.
https://doi.org/10.1021/acs.orglett.8b03501

- - - - - - - - - - 2018 年 - - - - - - - - - - Hisao Saneyoshi & Akira Ono“Development of Protecting Groups for Prodrug-Type Oligonucleotide Medicines”
Chem. Pharm. Bull., 2018, 66, 147-154.
https://doi.org/10.1248/cpb.c17-00696- - - - - - - - - - 2017 年 - - - - - - - - - - - Hisao Saneyoshi, Kazuhiko Kondo, Koichi Iketani, Akira Ono“Alkyne-linked reduction-activated protecting groups for diverse functionalization on the
backbone of oligonucleotides”
Bioorg. Med. Chem., 2017, 25, 3350-3356..
https://doi.org/10.1016/j.bmc.2017.04.020
Hisao Saneyoshi, Yuta Yamamoto, Kazuhiko Kondo, Yuki Hiyoshi, Akira Ono"Conjugatable/Bioreduction
Cleavable
Linkerforthe5′-Functionalization
Oligonucleotides"
J. Org. Chem., 2017, 82, 1796-1802
DOI:10.1021/acs.joc.6b02527
https://doi.org/10.1021/acs.joc.6b02527

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- - - - - - - - - - 2016 年 - - - - - - - - - - - Hisao Saneyoshi,,Koichi Iketani, Kazuhiko Kondo, Takeo Saneyoshi, Itaru Okamoto, andAkira Ono“Synthesis and Characterization of Cell-Permeable Oligonucleotides Bearing ReductionActivated Protecting Groups on the Internucleotide Linkages”
Bioconjugate Chem., 2016, 27, 2149–2156.
DOI:10.1021/acs.bioconjchem.6b00368
https://doi.org/10.1021/acs.bioconjchem.6b00368

Hisao Saneyoshi*, Kazuhiko Kondo, Naoki Sagawa, Akira Ono*
“Glutathione-triggered activation of the model of pro-oligonucleotide with benzyl protecting
groups at the internucleotide linkage”
Bioorg. Med. Chem. Lett., 2016, 26, 622-625.
doi:10.1016/j.bmcl.2015.11.064
https://doi.org/10.1016/j.bmcl.2015.11.064- - - - - - - - - - 2015 年 - - - - - - - - - - - Hisao Saneyoshi,* Yuki Hiyoshi, Koichi Iketani, Kazuhiko Kondo, Akira Ono*
“Bioreductive deprotection of protected thymine bases in oligonucleotides for the activationof duplex formation”
Bioorg. Med. Chem. Lett., 2015, 25, 5632-5635.
https://doi.org/10.1016/j.bmcl.2015.10.025

Hisao Saneyoshi,* Kanami Shimamura, Naoki Sagawa, Yuki Ando, Takahito Tomori, ItaruOkamoto, Akira Ono*
“Development of a photolabile protecting group for phosphodiesters in oligonucleotides”
Bioorg. Med. Chem. Lett., 2015, 25, 2129-2132.
https://doi.org/10.1016/j.bmcl.2015.03.064
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