Immunotoxicology Specialty
Section Newsletter
President’s Message
Gary Burleson, PhD
2013-2014
Executive Committee
President
Dr. Gary Burleson
Vice President
Dr. Danuta Herzyk
Vice President-ElectViP
id t El t
Dr. Rafael Ponce
Secretary-Treasurer
Dr. Haley Neff-LaFord
Past President
Dr. Gregory Ladics
Senior Councilor
Dr. Peyton Myers
Junior Councilor
Dr. Jamie Dewitt
PostDoc Representative
Dr Kinta Serve
Dr.
Student Representative
Aimee Hillegas

The ImTox SS Newsletter ispublished 3 times/year (Summer,(Summer
Fall, and Winter). If you would like toshare an item of interest withmembers of the ImTox SS, please
send it to the Communications
Committee Chair. All comments on,or suggestions to, the newsletter are
welcome.

Ashwini Phadnis-Moghephadnisa@msu.edu

December 2013

Time flies as it seems that only yesterday I was
writing the incoming President
President’ss Message.
Message
However, during that time, the ITSS Executive
Committee has been busy with scheduled
teleconferences the second Wednesday of eachmonth. We welcome input from the membershipand I want to encourage you to contact one of
the members of the executive committee if you
Dr. Gary Burleson
have items you want discussed.
President, ImTox SS
2013-2014

Please remember to select membership in the Immunotoxicology
Specialty Section when you renew your SOT membership. We are
the fourth largest of all 27 SOT Specialty Sections and we continue
to grow as more and more toxicologists are interested iniimmunotoxicology.
t i l
C t l toCentralt our success isi theth integration
i t
ti
off
toxicology and immunology where we recognize the importance of
the immune system in protection against infectious and neoplastic
disease, and in the inadvertent immune stimulation by xenobiotics
that results in hypersensitivity reactions or autoimmune disease.
Your membership is important in keeping us a growing and vibrantSpecialty Section.
SectionThe ITSS has a new Graduate Student Representative – Aimee
Hillegas. Aimee is a PhD student at the University of the Sciencesin Philadelphia and was nominated by her PhD advisor Dr. Vandana
Miller. Welcome Aimee! Danuta Herzyk is Chair of the Program
Committee for the upcoming SOT meeting and has worked hard to
obtain proposals for the 2014 SOT.
SOT
Please consult the SOTProgram and support the Immunotoxicology Specialty Section
sessions.
President’s Message…………………………………………………..…1
Student Post-doctoral Committee Report…………………....….…..2
Regulatory Committee Report………………………..………………..3pAwards Committee Report………………………………………….…..4
Financial Committee Report……………………………………………5
Program Committee Report…………………………………………….6
Membership Committee Report……………………………….…….…7
Recent publications…………………………………….………………..9
1

Immunotoxicology Specialty Section

The ITSS Executive Committee has initiated a new Award entitled: “Outstanding Senior
Immunotoxicologist Award.”
We now have the following awards that will recognize
immunotoxicology scientists of distinction at every career stage: Outstanding Young
Immunotoxicologist Award,Award Outstanding Senior Immunotoxicologist Award,Award and the Vos
Lifetime Career Achievement Award. Please examine the details and requirements for suchan award at the SOT Website: Immunotoxicology Specialty Section Award Descriptions andDeadlines. The deadline for nominations is 18 January 2014. We all know of many deserving
candidates. Please take the time to nominate and recognize a deserving immunotoxicologist.
I look forward to seeing you at the SOT Annual Meeting on 23-27 March 2014 in Phoenix,
Arizona!

Student & Postdoctoral Report
Submitted by Kinta Serve, PhD
Greetings, student and postdoctoral members! Please join me in welcoming our new graduate
student representative, Aimee Hillegas, a PhD student from the University of the Sciences in
Philadelphia, PA. Welcome, Aimee! In future newsletters, Aimee will keep us informed of thelatest Graduate Student Leadership Committee developments and plans. If you have any
questions or comments concerning graduate student activities or awards, please contact
Aimee at ahillegas@mail.usciences.edu.
A theAs
th endd off theth year approaches,hI hopeh
you are allll getting
tti excited
it d forf theth 53rd annuall SOT
meeting. Remember that there are many great opportunities for students and postdocs to get
involved, including creating a video for the YouTox challenge. Students and postdocs areinvited to submit a short video answering the question “Why did I become a toxicologist?”
Cash prizes will be awarded, so get creative and have some fun! (Deadline is Jan 15; more
information available at http://toxicology.org/ai/spd/studentservices.asp). Additionally, thedeadline for award nominations is quickly approaching.
approaching Awards available to students andpostdoctoral ImmunoTox members include Best Presentation by a Student, Best Presentation
by a Postdoctoral Trainee, and Best Paper of the Year. Many travel awards are also available
through the specialty section and through SOT; check out the websites for details anddeadlines.
A big thank you to all those who attended the Postdoctoral Assembly webinar in September
entitled “Exploring
Exploring Alternative Career Paths in Toxicology.
Toxicology.” This webinar was presented aspart of Postdoc Appreciation Week. If you weren’t able to attend, the recording is available on
the SOT website.
Lastly, I’d like to remind everyone to make sure their SOT member information is current andcorrect so you don’t miss email reminders of the numerous events and activities available tostudents and postdocs! Upcoming events include Chat with an Expert, Poster Tours, andStudent/Postdoc Mixers at the annual SOT meeting. If you would like to get involved inplanning these great events, or have any comments/suggestions, please contact Kinta Serve(servkint@isu.edu) or Aimee Hillegas (ahillegas@mail.usciences.edu).

December 20132

Immunotoxicology Specialty Section

Regulatory Committee Report
Submitted by Peter Thomas, PhD.
Chair,, Regulatorygy Subcommittee
The following regulatory update may be of interest to the Immunotoxicology specialty section
EPA Conducts Retrospective Analysis of Pesticide TDAR assay.
In response to a CropLife America (CRL) request, that the EPA consider granting waivers forth OPPTS.
theOPPTS 870.7800
870 7800 immunotoxicityi
t i it study,t d theth AgencyA
conducted
d t d a retrospectivetti analysis
l i off
over 170 pesticide studies where this guideline was followed. This analysis included study
data from 155 chemicals to determine (1) whether the results of the guideline-driven
immunotoxicology study impacted human health risk assessment; (2) if there is sufficientjustification for granting waivers for this study; and (3) propose a path forward.
The guideline-driven immunotoxicity study (TDAR assay) is designed to measure theimmunosuppressive potential of a chemical by measuring the antibody response to a T-cell
T celldependent antigen (SRBCs) in rodents treated for at least 28 days.
As background, CRL conducted a retrospective evaluation of 82 TDAR studies and noted that a
reduction in TDAR was noted in 4/82 studies at the high dose only. They concluded that in nocase was the finding the most sensitive endpoint when compared to other toxicity endpoints.
In the EPA review, all 155 chemicals were assessed by the TDAR using the PFC assay or
ELISA methods in rats or mice of both genders. In addition, a Natural Killer cell activity assay
was conducted for 11 chemicals. For the majority of chemicals tested, there was a lack of
toxicologically-relevant effects on the T-dependent antibody response. No effect on the TDAR
response up to the highest dose was seen in 140 of 155 chemicals tested. Ten percent of thechemicals ((15)) produced suppression of the anti SRBC TDAR response at “relativelyy highgdoses”. For 9 of the 15 chemicals, immunotoxicity was seen at the same, or at higher doses
than which systemic toxicity was noted.
To assess the impact of the immunotoxicity study on human health risk assessment, acomparison was made of the NOAEL/LOAEL established for the TDAR to the “points ofdeparture” selected for different risk assessment scenarios for the various chemicals. The EPA
statedt t d thatth t sinceiiimmunotoxicityt i it was nott theth mostt sensitive
iti endpointd i t ini theth databased t b
off thethchemicals used in this analysis, it would not have been used for risk assessment. Based on
this and other factors, the Office of Pesticide Programs will be receptive to requests that it grant
waivers for the immunotoxicity study. Such waivers should be made on a case-by-case basis
and include a scientifically sound rationale.
US Environmental Protection Agency Memorandum“A
A Retrospective Analysis of the
Immunotoxicity Study (OCSPP Test Guideline 870.7800). Feb 2013www.epa.gov/pesticides/regulating/immunotoxicity-retro-analysis.pdf

December 20133

Immunotoxicology Specialty Section

Call for Nominations from the Awards Committee
Submitted by Peyton Myers, PhD.
Chair Awards Committee
Chair,
It’s that time again! Awards for our outstanding Immunotoxicology colleagues!
Recognizing the scientific contributions of our students and colleagues is one of the mostimportant things we do. It not only recognizes them, but also publicizes the accomplishments of
our Specialty Section toward the mission of SOT. The Awards Committee strongly encourages
you to nominate your colleague(s), including self-nominations, for the various awards presented
by the Immunotoxicology Specialty Section. We hope to continue to see the same high qualityof nominees that challenges the Committee to choose among our very best!
Also note, we have a NEW Award this year! The Outstanding Senior Immunotoxicologist Award
goes to the outstanding candidate that has contributed to immunotoxicology for more than 10
years (the(th limit
li it forf theth “young”“” investigatoriti t award)d) butb t hash nott yett received
i d theth VosV CareerCAward! This award is designed to fill the gap in our awards platform to recognize many of ouroutstanding senior investigators that continue to advance the field of immunotoxicology.
Vos Award – Lifetime Career Achievement Award in Immunotoxicology
An award named for the late Prof. Jeff Vos shall be presented to a Senior Investigator withoutstanding achievements in immunotoxicology.
immunotoxicology Nominations should be submitted to Gary
Burleson by January 18, 2014.

Outstanding Senior Immunotoxicologist Award
Senior Investigator whose work has made significant contributions to the field of
Immunotoxicology.
u oto co ogy Thiss aaward
a d iss foro scscientists
e t sts in acade
academia,a, industry,
dust y, oor tthoseose whoo havea e hadad aanimpact on regulatory issues. Nominations should be submitted to Danuta Herzyk by January 18,
2014.
Outstanding Young Investigator Award
Promising young investigator(s) who have already had an impact on academic, regulatory orindustrial areas of immunotoxicology shall be awarded. Nominations should be submitted toDanuta Herzyk by January 18, 2014.
Best paper of the Year Award
This honored award shall go to the authors of the best paper in immunotoxicology publishedbetween Jan 1, 2013 and December 31, 2013. Date of first publication (e-version or paper
version) is considered the publication date for awards consideration purposes. Nominations
shouldh ld beb submitted
b itt d tot PeytonP t MyersM
b January
byJ
18 2014.
18,
2014

December 20134

Immunotoxicology Specialty Section

Call for Nominations from the Awards Committee(continued)
Best Presentation by a Postdoctoral Trainee Award
Nominees are asked to submit a complete written version of an immunotoxicology
presentation that is to be made at the 2013 SOT Annual Meeting, along with a letter of
nomination from the Postdoctoral Trainee’s advisor. Nominations should be submitted to
Peyton Myers by January 18, 2014.
Best Presentation by a Student Award
Nominees are asked to submit a complete written version of an immunotoxicology
presentation to be made at the 2013 SOT Annual Meeting, along with a letter of nominationfrom the student’s advisor. Nominations should be submitted to Peyton Myers by January 18,
2014.
HESI Immunotoxicology Young Investigator Travel Award
This award is offered by ILSI HESI to encourage young investigators within 5 years ofreceiving a Ph.D. to present their research at the 2014 SOT Annual Meeting. Nominations
should be submitted to Gary Burleson by January 18, 2014.
Detailed descriptions of all the awards are on the website:
http://www.toxicology.org/ISOT/SS/imtox/deadlines.asp.
Gary Burleson (gburleson@brt-labs.com), Danuta Herzyk (danuta_herzyk@merck.com), andPeyton Myers (Peyton.Myers@fda.hhs.gov) will accept nominations after December 1, 2013

SOT 2014 meetingg - upcomingpg deadlines

Deadlines
2nd abstract submission – January 6, 2013
Early Bird Registration – January 31, 2014
Standard Registration – February 28, 2014

December 20135

Immunotoxicology Specialty Section

Financial Report (2012-2013)
Submitted by Haley Neff-LaFord, PhD
The fiscal year runs for 12 months ending on June 30th (Data shown for end of year, June 2013)

All entries listed in USD, rounded to the nearest dollar.
Income includes dues (paid with SOT membership) andregistration (based on the number of ImTox SS
members at the SOT Annual Meeting).
Expenses include the ImTox SS Executive Meeting &Reception held at the SOT Annual Meeting,miscellaneous expenses (monies for ImTox Pool of
Lecturers, Student/Postdoc Mixer etc.)

December 20136

Immunotoxicology Specialty Section

Program Committee Update for 2014 SOT meeting
Submitted by Danuta Herzyk, PhD
On behalf of the 2013-2014 ITSS Program Committee, I want to thank everyone for submitting
their proposals for the 2014 SOT Annual Meeting. Our Specialty Section will be represented at themeeting in Phoenix, AZ with three sessions listed below:
Symposium – To Bug or Not to Bug the Immune System: Benefits and Consequences of
Altering the Microbiome
Co-Chairs: Victor J. Johnson and Berran Yucesoy
Symposium – Ocular Immunotoxicology: A Privileged View
Co-Chairs: Brian Christian and JoAnn Schuh
Workshop - Contribution of Nonimmune Cells to Adverse Immune Responses:
Implications for Toxicology
Co Chairs: Peer Karmaus and Barbara Kaplan
Co-Chairs:
While the number of ITSS-sponsored programs is down from the last year where we had fiveprograms (2 Symposia, 1 Workshop, 1 CEC and 1 Informational Session), it reflects the fact thatall proposals were submitted primarily as symposia, the most competitive program category.
At the same time, the higher bar for acceptance of proposals results from both the greater number
of SOT Specialty Sections and the greater quality of all submissions. Therefore, the Program
Committee extends congratulations not only to those who have been accepted but to ALL who
submitted their valuable proposals.

Membership Committee Report
Submitted by George DeGeorge, Ph.D
By Membership Category

14%

By Organization Category
Industry
Academia
Nov 2013
Government
3%
Consulting
Research (NP)Research (CRO) 6% 1%
Other
6%
38%

Nov 2013

0.2%

14%

9%
Full
A
Assoc
Student
Chapter Only Guest
December 201372%
Total = 417

37%
7

Immunotoxicology Specialty Section

Membership Committee Report (continued)
Total Members

500

400

300

200

100

0
Dec-03

Dec-04

Dec-05

Dec-06

Dec-07

Dec-08Dec-09Dec-10Dec-11

Dec-12

Dec-13

red dot = SOT takes this point as the yearly figure

Note:•
The "dip" occurs when SOT deletes those who haven't renewed•"estimated" in the graph below indicates an arbitrary 5% increase over Dec of last year
Immunotoxicology Specialty Section Membership
Estimated
Actual
SOT Total (July 31)

500

433

450
384

400
Total M
Members

250

417

321

297

300

433

355

349

350

402

455
419

220

200
150
100
50
0
Dec
2003

December 2013

Dec
2004

Dec
2005

Dec
2006

Nov
2007

8

Dec
2008

Dec
2009

Dec
2010

Dec
2011

Dec
2012

Nov
2013

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Compiled by Haley Neff-LaFord, PhD

Anytime you have a new fully-published or electronically-available article to report, please
send the citation at anyy time to the coordinator,, Haleyy Neff-LaFord: hnlaford@seagen.com@
gAsthma, Allergy, Autoimmunity & Hypersensitivity
Bølling AK, Holme1 JA, Bornehag CG, Nygaard UC, Bertelsen RJ, Nånberg E, Bodin J, Sakhi
AK, Thomsen C and Becher R. Pulmonary phthalate exposure and asthma – Is PPAR a
plausible mechanistic link? EXCLI J 12:733-759, 2013.
Choi J,
J Kim JR,JR Kim H,
H Kim YA,YA Lee HJ,
HJ Kim J and Lee KW.
KW The atopic dermatitis-like
symptoms induced by MC903 were alleviated in JNK1 knockout mice. Toxicol Sci 136:443449, 2013.
El Ali Z, Gerbeix C, Hemon P, Esser PR, Martin SF, Pallardy M and Kerdine-Romer S. Allergic
skin inflammation induced by chemical sensitizers is controlled by the transcription factor Nrf2.
Toxicol Sci 134:39-48,, 2013.
Lalko JF, Kimber I, Dearman RJ, Api AM and Gerberick GF. The selective peptide reactivity ofchemical respiratory allergens under competitive and non-competitive conditions.
J Immunotoxicol 10:292-301, 2013.
Nygaard UC, Samuelsen M, Marioara CD and Løvik M. Carbon nanofibers have IgE adjuvant
capacity but are less potent than nanotubes in promoting allergic airway responses," BioMed
Res Int 2013 Epub: doi: 10.1155/2013/476010.
Developmental Immunotoxicology
Buczynski BW, Yee M, Martin KC, Lawrence BP and O’Reilly MA. Neonatal hyperoxia alters
the host response to influenza A virus infection in adult mice through multiple pathways. AmerJ Physiol
Ph i l LungL
C ll MolCell
M l Physiol
Ph i l 305:L282-290,
305 L282 290 2013.
2013 Selected
S l t d as “Editor’s“Edit ’ Pick”
Pi k” ini June,J
2013.
Dietert RR. Natural childbirth and breastfeeding as preventive measures of immunemicrobiome dysbiosis and misregulated inflammation. J Anc Dis Prev Rem 1: 103.
doi:10.4172/2329-8731.1000103, 2013.
Granum B, Haug LS, Namork E, Stølevik SB, Thomsen C, Aaberge IS, van Loveren H, Løvik
M and Nygaard UC. Pre-natal exposure to perfluoroalkyl substances may be associated withaltered vaccine antibody levels and immune-related health outcomes in early childhood.
J Immunotoxicol 10:373-379, 2013.
Hansen JS,, NygaardygUC,, Andreassen M,, and Løvik
øM. Offspringp g IgE
g responsesp
are influenced
by levels of maternal IgG transferred in early life. Am J Reprod Immunol 70:359-371, 2013.

December 20139

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Roy A, Gaylo A, Cao W, Saubermann LJ and Lawrence BP. Neither direct nor developmental
exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice.
J Immunotoxicol 10:334
10:334-340
340, 2013.
2013
General Immunotoxicology
Abbès S, Salah-Abbès JB, Sharafi H, Jebali R, Noghabi KA and Oueslati R. Ability of
Lactobacillus rhamnosus GAF01 to remove AFM1 in vitro and to counteract AFM1
immunotoxicity in vivo. J Immunotoxicol 10:279-286, 2013.
Auttachoat W, McLoughlin CE, White KL and Smith MJ. Route-dependent systemic and local
immune effects following exposure to solutions prepared from titanium dioxide
nanoparticles. J Immunotoxicol. Epub: DOI: 10.3109/1547691X.2013.844750.
Bernstein DI, Kashon M, Lummus ZL, Johnson VJ, Fluharty K, Gautrin D, Malo JL, Cartier A,
Boulet LP, Sastre J, Quirce S, Germolec D, Tarlo SM, Cruz MJ, Munoz X, Luster MI
and Yucesoy B. CTNNA3 (α-catenin) gene variants are associated with diisocyanate asthma,
a replication study in a Caucasian worker population. Toxicol Sci 131:242-246, 2013.
Bodin J, Bølling AK, Samuelsen M, Becher R, Løvik M, and Nygaard UC. Long term bisphenol
A exposure accelerates insulitis development in diabetes-prone NOD mice. Immunopharmacol
Immunotoxicol 35:349-58, 2013.
Boverhof DR, Krieger SM, Hotchkiss JA, Stebbins KE, Thomas J and Woolhiser MR.
Assessment of the immunotoxic potential of trichloroethylene and perchloroethylene in rats
following inhalation exposure. J Immunotoxicol 10:311-320, 2013.
Chen Y, Liu F, Weng D, Song L, Li C, Tang W, Yu Y, Dai W and Chen J. Treg cells may regulateinterlukin-17
interlukin
17 production by modulating TH1 responses in 1
1,33-β-glucan-induced
β glucan induced lunginflammation in mice. J Immunotoxicol 10:253-261, 2013.
Deng X, Nanduri B, Tan W, Cheng B, Fan R and Pruett SB. Sodium methyldithiocarbamate
exerts broad inhibition of cellular signaling and expression of effector molecules ofinflammation. Toxicol Sci 136:430-442, 2013.
El-Gharabawy RM, El-Maddah EI, Oreby MM, Salem HAS and Ramadan MO. Immunotoxicity
and pulmonary toxicity induced by paints in Egyptian painters. J Immunotoxicol 10:270-278,
2013.
Guo TL, Germolec DR, Zhang LX, Auttachoat W, Smith MJ and White KL. Contact sensitizing
potential of hair dye components pyrogallol and 5-amino-o-cresol in female BALB/c mice.
Toxicology 314:202-208, 2013.

December 201310

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Hammad LN, Abdelraouf SM, Hassanein FS, Mohamed WA and Schaalan MF. Circulating IL-6,
IL-17 and vitamin D in hepatocellular carcinoma: Potential biomarkers for a more favorable
prognosis? J Immunotoxicol 10:380-386, 2013.
Head Wheeler JL, Martin KC and Lawrence BP. Novel cellular targets of AhR underlie
alterations in neutrophilic inflammation and iNOS expression during influenza virus infection. J
Immunol 190:659-668, 2013.
Inada T, Ueshima H and Shingu K. Intravenous anesthetic propofol suppresses leukotriene
production in murine dendritic cells. J Immunotoxicol 10:262-269, 2013.
Karimian P, Kavoosi G and Amirghofran Z. Anti-inflammatory effect of Mentha longifolia inlipopolysaccharide-stimulated macrophages: Reduction of nitric oxide production throughinhibition of inducible nitric oxide synthase. J Immunotoxicol 10:393-400, 2013.
Karmaus PWF, Wagner JG, Harkema JR, Kaminski NE and Kaplan BLF. Cannabidiol (CBD)enhances lipopolysaccharide (LPS)-induced(LPS) induced pulmonary inflammation in C57BL/6 mice.
mice
JImmunotoxicol 10:321-328, 2013.
Kimber I, Nookala S, Davis CC, Gerberick GF, Tucker H, Foertsch LM, Dearman RJ, Parsonnet
J, Goering RV, Modern P, Donnellen M, Morel J and Kotb M. Toxic shock syndrome:
Characterization of human immune responses to TSST-1 and evidence for sensitivity
thresholds Toxicol Sci 134:49
thresholds.
134:49-63
63, 2013.
2013
Latorre MA, López González EC, Larriera A, Poletta GL and Siroski PA. Effects of in vivo
exposure to Roundup® on immune system of Caiman latirostris. J Immunotoxicol 10:349-354,
2013.
Manningg CM,, Johnston CJ,, Hernadyy E,, Miller JH,, Reed CK,, Lawrence BP,, Williams JP and
Finkelstein JN. Exacerbation of lung radiation injury by viral infection: The role of Clara cells
and Clara cell secretory protein. Radiat Res 179:617-629, 2013.
Nworu CS, Nwuke HC, Akah PA, Okoye FBC and Esimone CO. Extracts of Ficus exasperata
leaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expressionof mediators of inflammation in macrophages. J Immunotoxicol 10:302-310, 2013.
O’Brien E, Dolinoy DC and Mancuso P. Bisphenol A at concentrations relevant to human
exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived
mast cells. J Immunotoxicology 11:84-89, 2014.
Olmedo H, Herrera M, Rojas L, Villalta M, Vargas M, Leiguez E, Teixeira C, Estrada R,
Gutiérrez JM
JM, León G and Montero ML
ML. Comparison of the adjuvant activity of aluminumhydroxide and calcium phosphate on the antibody response towards Bothrops asper snake
venom. J Immunotoxicol 11:44-49, 2014.

December 201311

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Panahi Y, Ghanei M, Vahedi E, Ghazvini A, Parvin S, Madanchi N, Bagheri M and Sahebkar A.
Effect of recombinant human IFNγ in the treatment of chronic pulmonary complications due tosulfur mustard intoxication. J Immunotoxicol 11:72-77, 2014.
Pascuan CG,
CG Uran SL,
SL Gonzalez-Murano
Gonzalez Murano MR,
MR Wald MR,
MR Guelman LR and Genaro AM.
AM
Immune alterations induced by chronic noise exposure: Comparison with restraint stress in
BALB/c and C57Bl/6 mice. J Immunotoxicology 11:78-83, 2014.
Popov A, Mirkov I, Vasilijic S, Zolotarevski L, Kataranovski D and Kataranovski M. Impact ofthe magnitude of sensitization dose on the incidence and intensity of CHS todinitrochlorobenzene (DNCB): Insight from ear swelling and challenged
challenged-skinskin draining lymph
node response in rats. J Immunotoxicol 10:355-360, 2013.
Rohlman D, Punj S, Pennington J, Bradford S and Kerkvliet NI. Suppression of acute graftversus-host response by TCDD is independent of the CTLA-4-IFNγ-IDO pathway. Toxicol Sci
135:81-90, 2013.
Salazar KD, Copeland CB, Wood CE, Schmid JE and Luebke RW. Evaluation of anti-nuclear
antibodies and kidney pathology in Lewis rats following exposure to Libby amphibole asbestos.
J Immunotoxicol 10:329-333, 2013.
Serve KM, Black B, Szeinuk J and Pfau JC. Asbestos-associated mesothelial cellautoantibodies promote collagen deposition in vitro. Inhal Toxicol 25:774-784, 2013.
Shao J, Katika MR, Schmeits PCJ, Hendriksen PJM, van Loveren H, Peijnenburg AA andVolger OL. Toxicogenomics-based identification of mechanisms for direct immunotoxicity.
Toxicol Sci 135:328-346, 2013.
Singh KP, Bennett JA, Casado FL, Walrath JL, Welle SL and Gasiewicz TA. Loss of arylhydrocarbon receptor promotes gene changes associated with premature hematopoetic stem
cells exhaustion and development of a myeloproliferative disorder in aging mice. Stem Cells
Dev Epub: DOI: 10.1089/scd.2013.0346
Smith MJ, Germolec DR, Frawley RP and White KL. Immunomodulatory effects of blackcohosh (Actaea racemosa) extract in female B6C3F1/N mice. Toxicology 308:146-157, 2013.
Soromou LW, Jiang L, Wei M, Chen N, Huo M, Chu X, Zhong W, Wu Q, Balde A, Deng X andFeng H.
Protection of mice against lipopolysaccharide-induced endotoxic shock bypinocembrin is correlated with regulation of cytokine secretion. J Immunotoxicol 11:56-61,
2014.
White KL, DeLorme MP, Beatty PW, Smith MJ and Peachee VL. Jet fuel kerosene is not
immunosuppressive in mice or rats following inhalation for 28 days. J Toxicol Env Health A
76:778-797, 2013.

December 201312

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Xing Y, Song HM, Wei M, Liu Y, Zhang YH and Gao L. Clinical significance of variations inlevels of Epstein-Barr Virus (EBV) antigen and adaptive immune response during chronic active
EBV infection in children. J Immunotoxicol 10:387-392, 2013.
Yousefzadi M, Riahi
Riahi-Madvar
Madvar A, Hadian J, Rezaee F, Rafiee R, Biniaz M. Toxicity of essential oilof Satureja khuzistanica: In vitro cytotoxicity and anti-microbial activity. J Immunotoxicol 11:5055, 2014.
Yucesoy B, Talzhanov Y, Johnson VJ, Wilson NW, Biagini RE, Wang W, Frye B, Weissman
DN, Germolec DR, Luster MI and Barmada MM. Genetic variants within the MHC region areassociated with immune responsiveness to childhood vaccinations. Vaccine 31:5381-91, 2013.
Zagorski JW, Turley AE, Dover HE, Vandenberg KR, Compton JR, and Rockwell CE. The Nrf2
activator, tBHQ, differentially affects early events following stimulation of Jurkat cells. Toxicol
Sci 136:63-71, 2013.
Zhu X and Uetrecht J. A novel TH17-type cell is rapidly increased in the liver in response toacetaminophen-induced
t i
h i d
d liliver iinjury:j
TH17 cells
ll andd th
the iinnate
t iimmune response.
J Immunotoxicol 10:287-291, 2013.
Methods/Models
Collinge M, Thorn M, Peachee V and White K Jr. Validation of a Candida albicans delayed-type
hypersensitivity (DTH) model in female juvenile rats for use in immunotoxicity assessments.
assessments J
Immunotoxicol 10:341-348, 2013.
Gibbs S, Corsini E, Spiekstra SW, Galbiati V, Fuchs HW, Degeorge G, Troese M, Hayden P,
Deng W and Roggen E. An epidermal equivalent assay for identification and ranking potency ofcontact sensitizers. Toxicol Appl Pharmacol 272:529-541, 2013.
Kamperschroer C, O’Donnell LM, Schneider PA, Li D, Roy M, Coskran TM and Kawabata TT.
Measuring T-cell responses against LCV and CMV in cynomolgus macaques using ELISPOT:
Potential application to non-clinical testing of immunomodulatory therapeutics. J Immunotoxicol
11:35-43, 2014.
Peachee VL, Smith MJ, Beck MJ, Stump DG, and White KL. Characterization of the Tdependent antibody response (TDAR) to keyhole limpet hemocyanin (KLH) in the Göttingen
Minipig®. J Immunotoxicol. Epub: DOI: 10.3109/1547691X.2013.853716
Van Mierlo GJD, Cnubben NHP, Wouters D, Wolbink GJ, Hart MHL, Ganderup NC, Kuper CF,
Aarden L and Penninks AH. The minipig as an alternative non-rodent model for immunogenicity
testing using the TNFα blockers adalimumab and infliximab. J Immunotoxicol 11:62-71, 2014.

December 201313

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Vogel CFA, Wu D, Goth SR, Baek J, Lollies A, Domhardt R, Grindel A and Pessah IN. Arylhydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-celldifferentiation. Immunol Cell Biol 912:568-575, 2013.
Yousefi M, Tahmasebi F, Younesi V, Razavi A, Khoshnoodi J, Bayat AA, Abbasi E, Rabbani H,
Jeddi-Tehrani M and Shokri F. Characterization of neutralizing monoclonal antibodies directedagainst tetanus toxin fragment C. J Immunotoxicol 11:28-34, 2014.
Papers from Meetings
Altamirano-Lozano MA, Alvarez-Barrera L, Mateos-Nava RA, Fortoul TI, and RodriguezMercado JJ. Potential for genotoxic and reprotoxic effects of vanadium compounds due tooccupational and environmental exposures: An article based on a presentation at the 8thInternational Symposium on Vanadium Chemistry, Biological Chemistry, and Toxicology,
Washington DC, August 15–18, 2012. J Immunotoxicol 11:19-27, 2014.
Fortoul TI, Rojas-Lemus M, Rodriguez-Lara V, Gonzalez-Villalva A, Ustarroz-Cano M, CanoGutierrez G, Gonzalez-Rendon SE, Montaño LF and Altamirano-Lozano M. Overview ofenvironmental and occupational vanadium exposure and associated health outcomes: An
article based on a presentation at the 8th International Symposium on Vanadium Chemistry,
Biological Chemistry, and Toxicology, Washington DC, August 15–18, 2012. J Immunotoxicol
11:13-18, 2014.
Reviews/ Books/Case Reports
Ainscough JS, Gerberick GF, Dearman RJ and Kimber I. Danger, intracellular signaling, andthe orchestration of dendritic cell function in skin sensitization. J Immunotoxicol 10:223-234,
2013.
Botti G, Cerrone M, Scognamiglio G, Anniciello A, Ascierto PA and Cantile M.
Microenvironment and tumor progression of melanoma: New therapeutic prospectives. J
Immunotoxicol 10:235-252, 2013.
Dietert RR. Developmental immunotoxicity, perinatal programming, and non-communicablediseases: Focus on human studies. Adv Med, 2013.
http://www.hindawi.com/journals/amed/aip/867805/
Dietert RR, Dietert J. Science Sifting: Tools for Innovation in Science and Research. World
Scientific Publishing, Singapore & London, 2013.
Growe RG, Luster MI, Fail PA and Lippes J. Quinacrine-induced occlusive fibrosis in thehuman fallopian tube is due to a unique inflammatory response and modification of repair
mechanisms. J Reprod Immunol 97:159-166, 2013.

December 201314

Immunotoxicology Specialty Section

Recent Immunotoxicology Publications
Krejsa CM, Blazej Neradilek M, Polissar NL, Cox N, Clark D, Cowan L, Bussiere J and Lebrec
H. An inter-laboratory retrospective analysis of immunotoxicological endpoints in non-humanprimates: Flow cytometry immunophenotyping. J Immunotoxicol 10:361-372, 2013.
Lawrence BP and Vorderstrasse BA. New insights into the aryl hydrocarbon receptor as amodulator of host responses to infection. Semin Immunopathol 35:615-626, 2013.
Luster MI. A historical perspective of immunotoxicology. J Immunotoxicol epub 2013
http://informahealthcare.com/doi/abs/10.3109/1547691X.2013.837121
Pfau JC, Hurley K, Peterson C, Coker L, Fowers C and Marcum R. Activation and trafficking ofperitoneal B1a B-cells in response to amphibole asbestos. J Immunotoxicol 11:90-98, 2014.
Ponce RA, Gelzleicher T, Haggerty HG, Heidel S, Holdren MS, Lebrec H, Mellon RD andPallardy M. Immunomodulation and lymphoma in humans. J Immunotoxicol 11:1-12, 2014.
Selgrade MJK, Blain RB, Fedak KM and Cawley MA. Potential risk of asthma associated within utero exposure to xenobiotics
13 2013xenobiotics. Birth Defects Res C Embryo Today 99:1
99:1-13,2013.

Other Notable Items

JOB OPPORTUNITIES
g a new section to benefit anyoneyg for aWe are starting
who is looking
new job or a career transition. If you are aware of a job opening that you
would like to see posted here, please email the details to the ImTox
Communicationscommittee
chair,
AshwiniPhadnis-Moghephadnisa@msu.edu. We will update this section in the upcoming
newsletters and also post them online on our website.
Employers who have job openings and would like to advertise them in our newsletter cansend the information to us in this format.
Position Available:
Institution or Company: Bottles R Us
Description: Chief Bottlewasher
Contact: Dr. Serve

SAVE THE DATE!
53rd Annual Society of Toxicology Meeting
March 23-27, 2014
Phoenix,, Arizonand
2 Abstract Submission deadline: January 6, 2014

December 201315

Immunotoxicology Specialty Section