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9 Sazers. 0 - Rainforest. (For the last few hours it appears to have.. such as br, b, t, l, m, w.. Add to Cart.Design of a novel
polycation-based antibacterial agent for infection: alteration of the amino acid components of the basic peptide. We previously
synthesized an antimicrobial peptide derived from a known protein, RGP4, composed of arginine, glycine, and a proline (ArgGly-Pro). This antibacterial peptide showed very potent activity against Gram-negative bacteria with a high rate ofpolycationicity, but it was less potent for Gram-positive bacteria and fungi. In this study, the antibacterial activity was enhanced
by reducing the amounts of Arg and Gly to glycine and alanine (Ala), respectively. Furthermore, to improve the activity toGram-positive bacteria and fungi, Arg and Gly were replaced with Ala and Glu, respectively. This novel peptide (a polycationic
antibacterial peptide, MPB) has the Arg-Gly-Pro sequence and three modified amino acids (Ala-Ala-Gly) at the N-terminal andArg-Gly-Pro-Gly-Ala-Ala at the C-terminal, respectively. MPB exhibited potent activity toward Gram-negative bacteria, Grampositive bacteria, and fungi. Furthermore, in a murine septicemia model, a substantial difference in the distribution of MPBtreated mice to pathogens was observed when compared with that of conventional peptides or antibiotics. Furthermore, MPB
showed no toxic side effects. These results indicate that MPB is a promising candidate as a new antimicrobial agent.[Antilipidemic effects of emodin and chrysophanol]. Emodin and Chrysophanol from Rheum palmatum were identified byspectrophotometer and gas chromatograph mass spectrometry. The activities of emodin and chrysophanol were investigated invivo, in vitro and in silico. In vivo studies were conducted on Swiss albino mice treated orally with emodin and chrysophanol at
0.01, 0.05, 0.1 and 0.5 g/kg once daily for consecutive 15 days. Each group consisted of six animals. Lipid profile parameters
including triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDLDownload1/2

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