The 5th Annual Meeting of JSIT
1998.9.21-22.
Senri Life Science Center, Life Hall （Toyonaka）
President: Kanehisa Morimoto (Osaka University Graduate School of Medicine)
Keynote Lecture
Lifewstyle andallergy/imumunotoxicology

Kanehisa Morimoto

Dep. of Hygiene and Preventive
Med. Osaka University

Ian Kimber

Zeneca Central Toxicology
Laboratory, Alderley Park,
Macclesfield, Cheshire

S. Ishikawa

President of The JapaneseSociety of Clinical Ecology

Special Lecture <1>
Chemical allergy： cellularmechanisms and new
approaches to hazard and risｋ assessment.
Special Lecture <2>
Effects ofenvironmentalchemical
substances on human body -Multiple Chmical Sensitivity(MCS) -Symposium
Stress and brain-immune
interaction.

T. Hori

Dept. of Physiology, Faculty ofMedicine, Kyusｈu University
Division of Cellular andMolecular Toxicology, National

Effects of restraint stressobservation on experiments
using mice-Jun Kanno

Effects of sex hormones onhuman reproductive immune
functions.

S. Hayakawa(1)，M. KarasakiSuzuki(1)，E.
Ohkoshi(2)，J.
Oyama(3)，T.
Kanaeda(1)，N.
Nagai(1)，M.
Ishii(1)，F.
Chisima(1)，K.
Satoh(1)Ovariectomy induces
enhanced production ofproinflammatory cytokinesfrom liver, kidney and bonemarrow cells.

Fujio Kayama(1)， (1)Department ofTakahiko Yoshida， Environmental Health, Jichi
Keisuke Nakatsuka Medical School

Endocrine disruptors andimmune responses.

Kou Sakabe

Institute of Health Sciences,
Department of Pathology andImmunology, Faculty ofMedicine, Tokyo Medical andDental University

Nihon University (1)School ofMedicine, (2)(3)School ofPharmacy

Division of Cellular Biology andSteroid Toxicology, Departmentof Morphology, Tokai University
School of Medicine

Workshop
Drug-specific immune
responses in guinea pigs.
Evaluation of allergic potentialof low molecular weight drugsby mouse popliteal lymph

N. Katsutani

test as a test for assessmentof antigenicity.

Delayed type hypersensitivity
and local lymph node assay.

Laboratories, Eisai Co., Ltd.
Laboratory Animal Science andK. Shinkai

Toxicology Laboratories, SankyoCo., Ltd.

node assay.
The guinea pig maximization

Drug Safety Research

H. Hattori，F.

Drug Safety Research Lab.,

Yamaguchi

Daiichi Pharm. Co., Ldt.

T. Hariya(1)，M.

Shiseido

Hatao(2)，M.

research laboratories，

Shibata(1)，T.

(2)materials research

Ashikaga(3)，H.
Ichikawa(1)laboratories，(3)Safety researchlaboratories

The results of surveys about
antigenicity studies conducted
N. Tsutsui
in the pharmaceuticalcompanies in Japan.

(1)skin biology

Toxicology Laboratory,
Yokohama Research Center,
Mitsubishi Chemical Corporation

General Presentation
Cellular and biochemical
aspects of immunotoxycity
manifestation of organotin
compounds.

Yasuaki Arakawa

Dept. of Hygiene & Preventive
Medicine, Faculty of Health
Sciences, The University ofShizuoka

Analysis of serum soluble Fasand soluble Fas ligand inpatients with siｌicosis.

A. Tomokuni，T.
Otsuki，A. Ueki

Dept. of Hygiene, Kawasaki
Medical School

Analysis of mRNA expression
in Fas-mediated apoptosis
inhibitor genes and caspases
in cases with silicosis.

T. Otsuki，A.
Tomokuni，A. Ueki

Dept. Hygiene, Kawasaki Med.
Sch.

Investigation of in vitro
antigenicity test.

T. Inoue，I. Horii

Dept. of Preclinical Science,
Nippon Roche Research Center

A new method for predictive
testing of contact seｎsitizers
using human monocyte cellline (THP-1).

N. Tsutsui，C.
Crist，J. Soejima

Toxicology Laboratory,
Yokohama Research Center,
Mitsubishi Chemical Corporation

Immunological characteristic
T. Aida，T.
of mouse popliteal lymph node Kimura，N.
reｓponse to low-molecularIshikawa，K.
allergenic compounds.
ShinkaiLaboratory Animal Science andToxicology Laboratories, SankyoCo., Ltd.

Establishment of rug-induced
and allergic interstitialnephritis model - Do as a new D. Takahashi et almeans of the antigen
screening for drugs -Faculty of PharmaceuticalSciences, Chiba University

Junko Soejima，Testing for active systemic
Sachikoanaphylactic reactions with NC Mochiduki，Isamu
mice.
Hosokawa，Naohisa Tsutsui

Toxicology Laboratory,
Yokohama Research Center,
Mitsubishi Chemical Corporation

H. Akiyama(1)，R.
An induction ofTeshima(2)，R.

(1)Div. of Foods，(2)Div. ofimmunogenicity through theNarimatsu(1)，Y.

Biochemistry andoral administration ofGoda(1)，J.

Immunochemistry, Nationalovalbumin(OVA).

Sawada(2)，M.

Institute of Health Sciences

Toyoda(1)Immunological tests ofM. Yokota，R.
peripheral blood neutrophils in Watanabe，M.
cynomolgus monkey.

Inoue

New approach to evaluate theSafety Assessment Laboratory,
Chugai Pharmaceutical Co., Ltd.
(1)Toxicology Division, The

modulation effects ofT. Kosaka(1)，Y.

chemicals on immune

Takeuchi(1)，response to Pneumococcal

K.Maita(1)，C. J.

polysaccharide-Pneumolysin
Conjugate antigen-Lee(2)Evaluation of immunotoxicity
tests using dexamethasone
and cyclosporin A-Ⅳ

M. Inoue，K.
Mochizuki，Y. Ito， Kaken Pharmaceutical Co., Ltd.
J. Yoshida，T. Arika

Induction of tight skin in miceby arsenic exposure: role ofGM-CSF and TGFα.

T. Yoshida(1)，H.
Aikawa(1)，K.
Sakabe(1)，F.
Kayama(2)，H.
Yamauchi(3)，W.
Fujimoto(4)(1)Tokai Univ. Sch. of Med.,(2)Jichhii Univ. Sch. of Med.，(3)St. Marianna Univ. Sch. ofMed.，(4)Okayama Univ. Sch.
of Med.

Effects of environmental
pollutants on the release ofproinflammatory cytokines
from normal human dermal
keratinocyte.

H. Ushio，H.
Fujimaki

Environmental Health Science
Div. National Institute forEnvironmental Studies

S. Yoshino(1)，H.
Role of diesel exhaust particles
in oral immunization.

Hayashi(2)，Y.
Mori(3)，M.
Ohsawa(4)，M.
Sagai(5)Institute of Environmental
Toxicology， (2)Center for
Biologics Evaluation andResearch/FDA(1)Dept. of Microbiology, Saga
Medical School，(2)Dept. ofClinical Toxicology andMetabolism，(3)Dept. ofImmunology and Microbiology,
Faculty of PharmaceuticalSciences, Health Sciences Uniｖ
ersity of Hokkaido，(4)Dept. ofEnvironmental Toxicology,
Faculty of PharmaceuticalSciences，Teikyo University，(5)Research Team for Health
Effects of AirPolutions, Nat.
Inst. for Environmental Studies

Detecｔion of intracellular
cytokines of mouse
Y. Takeuchi，T.
lymphocytes activated in vitro. Kosaka，T.

Toxicology Division， The
Institute of Environmental-Analysis using Flow
Cytometer(FCM)-Harada，K. Maita， Toxicology.

Effects of ovariectomy onspecific antibody responses inDevelopmental ResearchM. Nagata，M.
Laboratories, Shionogi & Co.,
Hino，K. Nakamura
Ltd.

rats.

Evaluation of specific IgE toA Imai(1)，M.
Japanese cedar pollen in sera Toriyama(1)，T.
of humans with pollinosis by a(1)Pharmaceutical Development
Laboratory, Kirin Brewery Co.,
Ltd., (2)Department ofhuman mast cell histamine-Imai(2)，M.

otorhinolaryngology, The Jikei

releasing test.

Yanagida(1)Uniｖersity School of Medicine

Allergic rhinitis and serum
immunological study inworkers exposed toK. Yamaguchi(1)，K. Yokota(1)，Y.
Jyoyama(1)，Y.

(1)Matsushita Science Center ofIndustrial Hygiene，(2)Dep. of

methyltetra- hydrophthalicanhydride in 2 condenser

Fujiki(1)，T.
Takeshita(2)，K.

Hygiene and Preventive Med.
Osaka University

manufacturing factories.

Morimoto