生活習慣病予防診療部
Ａ欧文Ａ‑ａ
１．Fujita N,Sakamaki H,Uotani S,Takahashi R,Kuwahara H,Kita A,Oshima K,Yamasaki H,Yamaguchi Y,Eguchi K:Acute effects of ethanol on feeding behavior and leptin‑induced STAT3 phosphorylation in rat
hypothalamus. Int J Obesity 27(1):55‑59, 2003 ★
２．Kita A,Uotani S,Kuwahara H,Takahashi R,Oshima K,Yamasaki H,M izuguchi H,Hayakawa T,NagayamaY, Yamaguchi Y, Eguchi K:Vanadate enhances leptin‑induced activation of JAK/STAT pathway in CHO
cells. Biochem Biophys Res Commun 302(4):805‑809, 2003 ▽３．Ozaki M, Yamasaki H, Kondo H, Yamasaki S, Fujita N, Yamauchi M ‑D, Abe T, Yamakawa K, Sera Y,Uotani S, Kawasaki E, Takino H, Kijima H, Kondo T, Yamaguchi Y, Eguchi K: Enhanced insulin gene
expression by reduced intracellular glutathione level in insulin secreting cells M IN6.Diabetes Nutr M etab 16(2):81‑87, 2003 ○４．Kuwahara H, Uotani S,Abe T,Degawa‑Yamauchi M ,Takahashi R,Kita A,Fujita N,Oshima K,SakamakiH,Yamasaki H,Yamaguchi Y,Eguchi K:Insulin attenuates leptin‑induced STAT3 tyrosine‑phosphorylation
in a hepatoma cell line. M ol Cell Endocrinol 205(1‑2):115‑120, 2003 ○▽５．Imagawa A, Hanafusa T, Uchigata Y, Kanatsuka A, Kawasaki E, Kobayashi T, Shimada A, Shimizu I,Toyoda T,M aruyama T,Makino H:Fulminant type 1 diabetes ‑a nationwide survey in Japan.Diabetes Care
26(8):2345‑2352, 2003
６．Ide A, Kawasaki E, Abiru N, Sun F, Fukushima T,Takahashi R,Kuwahara H,Fujita N,Kita A,Oshima K,Uotani S,Yamasaki H,Yamaguchi Y,Kawabata Y,Fujisawa T,Ikegami H,Eguchi K:Stromal‑cell derived
factor‑1 chemokine gene variant is associated with type 1 diabetes age at onset in Japanese population.HumImmunol 64(10):973‑978, 2003
７．Shimizu I, Makino H, Osawa H, Kounoue E, Imagawa A, Hanafusa T, Kawasaki E, Fujii Y:Association offulminant type 1 diabetes with pregnancy. Diabetes Res Clin Pract 62(1):33‑38, 2003
８．Origuchi T,Kawasaki E,Ide A,Kamachi M,Tanaka F,Ida H,Kawakami A,M igita K,Eguchi K:Correlation
between interleukin 10 gene promoter region polymorphisms and clinical manifestations in Japanese patientswith Sjogrenʼs syndrome. Ann Rheum Dis 62(11):1117‑1118, 2003
９．Fujita N,Sakamaki H,Uotani S,Takahashi R,Kuwahara H,Kita A,Oshima K,Yamasaki H,Yamaguchi Y,
Eguchi K:Intracerebroventricular administration of insulin and glucose inhibits the anorectic action of leptin
in rats. Exp Biol Med 228(10):1156‑1161, 2003 ★

Ａ‑ｂ
１．Kawasaki E,Ide A,Abiru N,Fukushima T,Takahashi R,Kuwahara H,Kita A,Oshima K,Uotani S,YamasakiH,Yamaguchi Y,Eguchi K:Evidence for gene‑gene interaction between IL‑18 gene promoter polymorphisms
with susceptible HLA and CTLA‑4 gene in Japanese type 1 diabetes. Diabetes 52(suppl 1):A25, 2003

Ａ‑ｃ
１．Kawasaki E, Abiru N, Ide A, Sun F, Takahashi R, Kuwahara H, Fujita N, Kita A, Oshima K, Uotani S,
Yamasaki H,Yamaguchi Y,Eguchi K:No evidence of mutations in the HNF‑1αgene or A‑to‑G mutation atposition 3243 of the mitochondrial tRNA
gene in patients with fulminant type 1 diabetes.Perspectivesof Diabetes in the New M illenium 76‑78, 2003
２．Ide A, Kawasaki E, Abiru N, Sun F, Fukushima T,Takahashi R,Kuwahara H,Fujita N,Kita A,Oshima K,Uotani S, Yamasaki H, Yamaguchi Y, Eguchi K: Interleukin‑10 gene promoter region polymorphisms inJapanese patients with latent autoimmune diabetes in adults. Perspectives of Diabetes in the New M illenium
67‑69, 2003
３．Abiru N,Sun F,Kawasaki E,Yamasaki H,Oshima K,Nagayama Y,Mizuguchi H,Hayakawa T,M iao D,LiuE,Eisenbarth GS,Eguchi K:In vivo expression of B:9 ‑23 peptide/I‑A complex may abrogate the inhibitionof diabetes induced by RGD‑fiber‑mutant adenovirus in NOD mice. Ann NY Acad Sci 1005:218‑221, 2003★
４．Ide A, Kawasaki E, Abiru N, Sun F, Fukushima T, Ishii R, Takahashi R, Kuwahara H, Fujita N, Kita A,150

長崎大学医学部業績集 ２．研究業績

Imaizumi M, Oshima K, Usa T, Uotani S, Ejima E, Yamasaki H, Ashizawa K, Yamaguchi Y, Eguchi K:
Interleukin‑10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroiddisease. Ann NY Acad Sci 1005:344‑347, 2003 ◎◇５．Ide A, Kawasaki E, Abiru N, Sun F, Fukushima T, Ishii R, Takahashi R, Kuwahara H, Fujita N, Kita A,Imaizumi M, Oshima K, Usa T, Uotani S, Ejima E, Yamasaki H, Ashizawa K, Yamaguchi Y, Eguchi K:
Association of interleukin‑18 gene promoter polymorphisms in type 1 diabetes and autoimmune thyroid
disease. Ann NY Acad Sci 1005:436‑439, 2003 ◎◇６．Kawasaki E, Abiru N, Ide A, Sun F, Fukushima T,Takahashi R,Kuwahara H,Fujita N,Kita A,Oshima K,Uotani S, Yamasaki H, Yamaguchi Y, Eguchi K: Epitope analysis on GAD65 autoantibodies in Japanesepatients with autoimmune diabetes. Ann NY Acad Sci 1005:440‑448, 2003
７．Kawasaki E:Radioimmunoassay:Technical background.Biomedical Technology and Devices Handbook 17‑1
‑17‑10, 2003

Ｂ邦文Ｂ‑ａ
１．高橋亮子、山口義彦、榎本 寛、魚谷茂雄、桑原宏永、藤田成裕、喜多篤志、大島勝也、酒巻宏行、山崎浩則、江口勝美：運動療法中に疲労骨折をきたした肥満２型糖尿病患者の１例、糖尿病 46(4)317‑323、2003
２．藤田成裕、山崎浩則、桑原宏永、福島徹也、古林正和、高橋亮子、喜多篤志、大島勝也、宮副治子、阿比留教生、魚谷茂雄、川崎英二、山口義彦、江口勝美：インスリン抵抗症Ｂ型の１例−患者 IgG によるインスリン受容体蛋白レベルの著減、Diabetes Journal 31(4)20‑23、2003

Ｂ‑ｂ
１．川崎英二、牧野英一：１型糖尿病：抗グルタミン酸デカルボキシラーゼ（GAD）抗体、綜合臨
52(1)：91‑94、2003
２．川崎英二、江口勝美：１型糖尿病の分子マーカー、医学のあゆみ 207(9):719‑723、2003
３．川崎英二、阿比留教生：樹状細胞免疫による１型糖尿病の発症阻止に関する研究、インスリン研究2003（年報）
25：33、2003
４．山崎浩則、大島勝也、喜多篤志、魚谷茂雄、山口義彦、水口裕之、早川尭男：レプチンのインスリン遺伝子発現に与える抑制作用の機序と SOCS3 による改善作用の検討、インスリン研究2003（年報）25：34‑35、2003

原著論文数一覧
Ａ‑ａ2003

Ａ‑ｂ Ａ‑ｃ9

1Ａ‑ｄ合計SCI

B‑ａB‑ｂB‑ｃB‑ｄ合計

総 計017142400623合 計

総 計

28327

学会発表数一覧
Ａ‑ａ2003

Ａ‑ｂシンポジウム

学会

031合計

Ｂ‑ａ42B‑ｂシンポジウム

学会

026

原著論文総数に係る教官生産係数一覧
欧文論文総数 教官生産係数 ＳＣＩ掲載論文(論文総数)
2003

0.739

教官生産係数（欧文論文) 欧文論文総数 （ＳＣＩ掲載論文)
170.82414151

Impact factor 値一覧
2003

Impact factor

１教官当たり Impact factor

論文当たり Impact factor

34.56934.5692.469152