病態解析医学
薬理学第一Ａ

欧文

Ａ‑ａ１．Zhou F, Tanaka K, Soares M J, You G:Characterization of an organic anion transport system in a placentalcell line. Am J Physiol (Endocrinol Metab) 285:E1103‑1109, 2003
２．Tanaka K,Towata S,Nakao K,M izuguchi H,Hayakawa T,Niwa M,Ishii N,Nagayama Y:Thyroid cancer
immuno‑therapy with retrovi ral and adenoviral vectors expressing granulocyte‑macrophage colony stimulating factor and interleukin‑12 in a rat model. Clin Endocrinol 59:734‑742, 2003 ☆
３．Yoshida A,Sakurai‑Yamashita Y,Yamashita K,Tanaka N,Taniyama K:Role of endothelin ET and ET
receptors in the guinea‑pig urinary bladder contraction. Eur J Pharmacol 470:99 ‑102, 2003 ☆
４．Sakurai‑Yamashita Y, Yamashita K, Niwa M , Taniyama K:Involvement of 5‑hydroxytryptamine receptor
in the exacerbation of neuronal loss by psychological stress in the hippocampus of SHRSP with a transientischemia. Brain Res 973:92‑98, 2003 ☆
５．Kurokawa M, Koichi Fujimura K, Sakurai‑Yamashita Y:A new‑generation apparatus for studying memory‑related performance in mice. Cell Mol Neurobiol 23:121‑129, 2003 ☆
６．Yanagi K,Nagayama Y,Nakao K,Saeki A,M atsumoto K,Ohata K,Ichikawa T,Ishikawa H,Hamasaki K,Ishii N, Eguchi K:Immuno‑gene therapy with adenoviruses expressing fms‑like tyrosine kinase 3 ligand andCD40 ligand for mouse hepatoma cells in vivo. Int J Oncol 22:345‑351, 2003 ○☆
７．Kita‑Furuyama M,Nagayama Y,Pichurin P,M cLachlan SM ,Rapoport B,Eguchi K:Dendritic cells infectedwith adenovirus expressing the thyrotropin receptor induce Gravesʼhyperthyroidism in BALB/c mice. Clin
Exp Immunol 131:234‑240, 2003 ☆
８．Nagayama Y,McLachlan SM,Rapoport B,Niwa M :A major role for non‑major histocompatibility complex
genes but not for microorganisms in a novel murine model of Gravesʼhyperthyroidism, Thyroid 13:233‑238,
2003 ☆
９．Nagayama Y,Mizuguchi H,Hayakawa T,Niwa M ,M cLachlan SM,Rapoport B:Prevention of autoantibody‑mediated Gravesʼ‑like hyperthyroidism in mice by IL‑4, a Th2 cytokine. J Immunol 170:3522‑3527,2003☆
10．Kita A,Uotani S,Kuwahara H,Takahashi R,Oshima K,Yamasaki H,M izuguchi H,Hayakawa T,Nagayama
Y, Yamaguchi Y, Eguchi K:Vanadate enhances leptin‑induced activation of JAK/STAT pathway in CHOcells. Biochem Biophys Res Commun 302:805‑809, 2003
11．Schwarz‑Lauer L,Pichurin P,Chen C‑R,Nagayama Y,Paras C,Morris JC,Rapoport B,M cLachlan SM :The
cysteine‑rich amino‑terminus of the Thyrotropin receptor is the immunodominant linear antibody epitope inmice immunized using naked DNA or adenovirus vectors. Endocrinology 144:1718‑1725, 2003
12．Guo J, Pichurin P, Nagayama Y, Rapoport B, McLachlan SM :Insight into antibody responses induced byplasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. Clin Exp Immunol
132:408‑415, 2003
13．Chen C‑R, Pichurin P, Nagayama Y, Latrofa F, Rapoport B, McLachlan SM : The thyrotropin receptor
autoantigen in Gravesʼdisease is the culprit as well as the victim. J Clin Invest 111:1897‑1904, 2003
14．Nagayama Y, Nakao K, Mizuguchi H, Hayakawa T, Niwa M : Enhanced antitumor effect of combined
replicative adenovirus and non‑replicative adenovirus expressing interleukin‑12 in an immunocompetentmouse model, Gene Therapy 10:1400‑1403, 2003
15．Abiru N,Sun F,Kawasaki E,Yamasaki H,Oshima K,Nagayama Y,Mizuguchi H,Hayakawa T,M iao D,LiuE,Eisenbarth GS,Eguchi K:In vivo expression of B:923 peptide/I‑Ag7 complex may abrogate the inhibitionof diabetes induced by RGD‑fiber‑mutant adenovirus in NOD mice.Ann NY Acad Sci 1005:218‑221,2003
16．Pichurin P, Aliesky H, Chen C‑R, Nagayama Y, Rapoport B, McLachlan SM :Thyrotropin receptor‑specificmemory T cell responses require normal B cells in a murine model of Gravesʼdisease.Clin Exp Immunol 134:396‑402, 2003
17．Saeki A, Nakao K, Nagayama Y, Yanagi K, Matsumoto K, Hayashi T, IshikawaH, Hamasaki K, Ishii N,Eguchi K:Diverse efficacy of vaccination therapy using the α‑fetoprotein gene against hepatocellular carcinoma. Int J Oncol 13:111‑116, 2003
18．Yamamoto S,Furukawa H,Kitamoto T,Takamaru Y,M orita N,Yasuda M ,Okada Y,Sawa H,Nagashima20長崎大学医学部業績集 ２．研究業績
K:An atypical form of sporadic panencephalopathic Creutzfeldt‑Jakob disease in Japan. Neuropathol Appl
Neurobiol 29:77‑80, 2003
19．Kis B, Csongor CS, Deli M A, Kobayashi H, Niwa M , Yamashita H, Busja DW, Ueta Y:Adrenomedullin, anautocrine mediator of blood‑brain barrier function. Hypertension Res 26:S61‑S70, 2003 ☆

Ａ‑ｂ
１．Nagayama Y:Novel murine models of thyroid autoimmunity:Current Opinion in Endocrinology& Diabetes
10:364‑370, 2003
２．Taniyama K, Sakurai‑Yamashita Y, Uezono Y, Kaibara M , Kanematsu T: Involvement of 5‑hydroxytryptamine (serotonin) receptors in intestinal motility and ion transport. Jpn. J. Surg. M etab. Nutr. 37:171‑178, 2003
３．Hayashi K,Nakao S,Nakagawa S,Deli M A,Niwa M :Hypoxic damages of the BBB:An in vitro study with
the new BBB model. Regul Peptides 115:47, 2003

Ｂ

邦

文Ｂ‑ｂ
１．山下康子、丹羽正美、谷山紘太郎：脳卒中と薬、脳 21 ６：79‑84、2003
２．古川ひさ子、丹羽正美：プリオン病の早期診断 臨床症候と検査所見（プリオン病の新しい展開）、最新医学 58：1035‑1040、2003
３．古川ひさ子：プリオン病早期診断方法開発の展望、獣医畜産新報 56：361‑365、2003
４．古川ひさ子、高橋三津雄、山田達夫：プリオン病最近の話題、最新精神医学 ８：31‑38、2003、2003

原著論文数一覧
Ａ‑ａ2003

Ａ‑ｂ Ａ‑ｃ1930Ａ‑ｄ合計SCI

B‑ａB‑ｂB‑ｃB‑ｄ合計

総 計

022190400426合 計

総 計

1017

学会発表数一覧
Ａ‑ａ2003

Ａ‑ｂシンポジウム

学会

241合計

Ｂ‑ａ72B‑ｂシンポジウム

学会

44

原著論文総数に係る教官生産係数一覧
欧文論文総数 教官生産係数 ＳＣＩ掲載論文(論文総数)
2003

0.846

教官生産係数（欧文論文) 欧文論文総数 （ＳＣＩ掲載論文)
7.333

0.864

6.333

Impact factor 値一覧
2003

Impact factor

１教官当たり Impact factor

論文当たり Impact factor

68.20622.7353.5921