Tottori J. Clin. Res. 7(2), 93-100, 2016

Differences in the use of drugs for the treatment of somatic complications between
psychiatric out- and inpatients
Yasuyuki Sakamoto1)*, Tsuruhei Sukegawa2), Toru Itano1), Akihiro Hirami1), Takumi Momode1),
Eri Kadono1), Kouichirou Miyoshi1)1) Department of Pharmacy, Tottori Medical Center, National Hospital Organization
2) Department of Psychiatry, Tottori Medical Center, National Hospital Organization*Correspondence: sakamoto-yasuyuki@tottori-iryo.hosp.go.jp
Abstract
Objective: Psychiatric treatment varies between out- and inpatients. This study examined the use of drugs
for the treatment of somatic complications, focusing on possible differences in such conditions between those
whose lifestyles differ. Methods: Differences in the rate of using drugs (drug use rate) for the treatment ofsomatic complications (laxatives/gastrokinetic drugs, other gastrointestinal drugs, antidiabetics, -hypertensives,-hyperuricemics, -hyperlipidemics, diuretics, cardiovascular drugs, antasthmatics, and antiosteoporotics)
between out- and inpatients were analyzed after adjusting for the gender, age, and antipsychotic dose. Results:
Significant differences were observed only in the laxative/gastrokinetic drug use rate. Discussion: While
psychiatric patients suffered from insufficient exercise and stress due to closed environments, medical
professionals tended to treat inpatients in severe conditions and use high-dose antipsychotics or -cholinergics
with increased doses of laxatives/gastrokinetic drugs in fear of paralytic ileus. This may have resulted in avicious circle in which the gastric function decreases, promoting laxative/gastrokinetic drug use. Tottori J. Clin.
Res. 7(2), 93-100, 2016
Key Words: type of treatment, laxatives/gastrokinetic drugs, exercise, stress, long-term high-dose
administration
Subjects
The study involved 492 (as of September 1,2013) out- and 85 (as of October 31, 2013)
inpatients with schizophrenia spectrum disorders
treated at the National Hospital Organization Tottori
Medical Center (the study facility).
Methods
From medical records, the following data werecollected for both out- and inpatients: gender, age,status of psychotropic use, and use/non-use of drugs
for the treatment of somatic complications(laxatives/gastrokinetic drugs, other gastrointestinal
drugs, antidiabetics, -hypertensives, -hyperuricemics, -hyperlipidemics, diuretics, cardiovascular
drugs,
antasthmatics,andantiosteoporotics).
For each type of psychotropic, the medians,means, and standard deviations of the following
items were calculated: antipsychotics: dosing

Introduction
In psychiatry, treatment varies between outand inpatients showing lifestyle differences. While
the former are allowed to freely perform theiractivities, the latter face activity limitations to agreater or lesser extent even in the case of voluntary
hospitalization. Due to such differences, somaticcomplications are also likely to vary between them.
However, to the present, differences in their somaticcomplications have not been reported, except for
the finding that such conditions varied between
psychiatric inpatients on closed and open wards1).
This study analyzed differences in the rate ofusing drugs (drug use rate) for the treatment ofsomatic complications between out- and inpatients
after adjusting for the sex, age, and antipsychotic
dose.
Methods
1