EXCELLENCE IN THE
ESSENTIAL TREATMENTPLANNING TECHNIQUESThe RayPlan® * treatment planning system makes proven, innovative
RayStation® technology accessible to clinics that need a cost-effective
and streamlined solution. Fast, efficient and straightforward to use,
RayPlan supports the full range of treatment planning activities for
3D-CRT, IMRT, VMAT, TomoTherapy and electron beam radiation therapy.
*Regulatory clearance needed in some markets

3

WHY SOFTWARE
MATTERS

4

SPEED
AND ACCURACY
GPU-powered computation
Monte Carlo dose calculation
Collapsed Cone dose calculation

ADVANCINGCANCER
TREATMENT1

5-6

PHOTONAND ELECTRON
3D-CRT
IMRT
VMAT
Electrons
TomoTherapy
Stereotactic planningMR-based planning7- 8

THE PHYSICIANTOOLBOX
Manual and semi-automatic contouring
Plan evaluation
Virtual simulation

9-10

COMMISSION,CHECK, GO

11-12

Modeling
Quality Assurance
Seamless connectivity
Hardware independence

SERVICEOFFERING
Smooth go-clinical process
A comprehensive service contract
RayPlan online community
Trainings
User meetings

13-14

FEATURESOVERVIEW

2

SOFTWARE HAS
UNLIMITED POTENTIAL
No one wants to wait for better cancer
treatment, and software is a way to acceleratechange. Software refinements make it possible
to keep pace with new techniques and discoveries
in an efficient manner.
Radiation therapy equipment is a significant investment. However all
too often, software is an afterthought rather than an integral aspect.
Thoughtfully designed software is the key to realizing the full potentialof equipment and getting the best return on investment.
But RayPlan is more than just software. It incorporates the knowledge andexperience of a team of experts dedicated to bringing scientific advancements incancer treatment faster to the clinical world. RaySearch continuously enhances thesystem, paying as much attention to small improvements as to major additions. Everydevelopment is designed to support you in securing better outcomes and improved
access to care.

UNIQUE AND CONTINUOUS MACHINE COMPATIBILITY - with most linacs, OIS and third-party QA
FAST DEVELOPMENT PACE - you will always be at the cutting edge of treatment planning
PROVEN TRACK-RECORD - a large community of enthusiastic users
WORLD-CLASS SERVICE - support where and when you need it
UNRIVALED SPEED - outstanding plan quality within seconds
ACCURACY FIRST - ensuring you deliver what you planned for
COST EFFECTIVE HARDWARE OPTIONS - for more flexibility
OPTION TO UPGRADE TO RAYSTATION - to access additional advanced features3

SPEED AND ACCURACYYIELDS PLAN QUALITY
RayPlan's unrivaled computation speed canradically transform your treatment planning process.
As the computation time is measured inseconds rather than minutes, you canefficiently produce several competing
treatment plans to assess different tradeoff situations and avoid interruptions.
This has been shown to contribute to overallplan quality. For example, decreasing calculation
times for VMAT planning, from around 10-17
minutes for optimization and final dose calculation to around 2-4 minutes, significantly
increased the fulfillment of clinical goals*.
RayPlan also offers the possibility to use Monte
Carlo dose algorithms**, providing the highest
level of accuracy. All the calculations
are run on GPU, enabling the outstanding results
displayed to the right***.

KEY FEATURES• Monte Carlo (MC) algorithms for photons
and electrons• Collapsed Cone (CC) photon dose
calculation engine• Singular value decomposition photon dose
calculation engine for real-time purposes

IMRT

7 BEAM PROSTATE
1 MILLION VOXELS
26/40 ITERATIONSDUAL ARC

5s

CC OPTIMIZATION

2.5s
CC FINAL DOSE

83s

LUNG
3.7 MILLION VOXELS MC OPTIMIZATION
72/80 ITERATIONS 1% UNCERTAINTY

16s
MC DOSECOMPUTATION
1% UNCERTAINTY* Case Study “The effect of planning speed on VMAT
plan quality.”** MC dose for photons will be available to all RayPlan
users, but is limited to selected sites in RayPlan 8B.
***Results may vary as dose computation time depends
on several variables.

70s

CC OPTIMIZATION

15s

CC FINAL DOSEVMATPROSTATE
1 MILLION VOXELS
40/40 ITERATIONS

21s

MC OPTIMIZATION
1% UNCERTAINTY

10s
MC DOSECOMPUTATION
1% UNCERTAINTY

4

ONE SYSTEM. ENDLESSPOSSIBILITIES.
RayPlan’s ultrafast multi-purpose optimization engine cansolve virtually any optimization problem within radiation
therapy, using many degrees of freedom of the treatment unit.

5

3D-CRT

ELECTRONS

Fast and consistent conventional 3D-CRT treatment
planning with manual and automatic tools for conformal
treatment using treat- and-protect, beam weighting,wedges, etc. Modern inverse planning techniques areprovided for creating conventional 3D-CRT plans, which
can be automatically optimized in regard to any combination of segment shapes, segment monitor units,
collimator, gantry and couch angles.

Creation of mixed electron and photon plans is enabled,with multiple coupled or independent beam sets appliedin a single treatment plan. 3D visualization of the treatment
setup makes it possible to inspect the physical perimeterof the selected applicator in relation to the patient geometry,
which assists in collision avoidance. The electron module
supports automatic generation of the cutout shape, using
the same treat-and-protect tools as the 3D-CRT module.
The cutout can also be created and edited using manual tools.

IMRT

STEREOTACTIC PLANNING

State-of-the-art tools make it simple to design andoptimize IMRT treatment plans. Direct machine parameter
optimization ensures high quality step-and-shoot andsliding window plans and speeds up the planning anddelivery processes.

Use the same software for steretotactic as for the rest of yourtreatments. RayPlan offers many proven tools to support thecreation of high-quality stereotactic workflows. Thanks to the
GPU technology, it takes seconds to calculate complex IMRTand VMAT plans, typical for stereotactic treatments,
even for dose grids with resolution as fine as 1 mm.

VMAT

TOMOTHERAPY PLANNING

Design and optimization of single- or multiple-arc
VMAT plans through an optimization procedure (inverse
planning). Objectives and constraints are defined forthe desired dose, and the system creates a plan thatmatches these criteria as closely as possible within
the limitations of the treatment machine. The optimized
plan is directly deliverable, without the need for postprocessing that might degrade quality.

RayPlan supports planning of TomoTherapy treatments.
Optimization capabilities for the TomoTherapy machine
include dynamic jaw support, delivery time constraints andthe possibility to specify “protect” regions where irradiation is
avoided. TomoTherapy planning can be smoothly integrated
into the clinical workflow and treatment plans are sent
to Accuray’s integrated data management system fordelivery (IDMS 1.1 or later is required).

MR-BASED PLANNING
An MR image can be used as the planning image for photon
therapy. MR images provide superior soft-tissue contrast
compared to CT images, which enables better characterizationof soft tissue and improved delineation of tumors andorgans at risk. Planning is based on a user-defined bulk
density assignment approach.

CO-OPTIMIZATION OF MULTIPLE BEAM SETS
Two beam sets in a plan can be optimized
simultaneously, and co-optimized beam sets sharean objective function list. Objective functions can be
assigned to each beam-set dose, or to their sum. Thisfeature enables efficient planning of non-integrated
boost treatments. SMLC, DMLC and VMAT are supported.

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A COMPREHENSIVE TOOLBOXFOR PHYSICIANS
RayPlan provides a comprehensive
toolbox for anatomical modeling andplan evaluation.
ACCURATE AND EFFICIENT CONTOURING
RayStation provides you with fast and user-friendly tools toefficiently and accurately contour the patient in the treatment
planning process. It includes a comprehensive toolset, ranging
from manual tools to high-end semi-automatic and fully automatic contouring tools.

Image registration/fusion
Rigid registration of multi-modality imaging CT, CBCT, PET and MR
is fully supported. It can be used for showing fused images as areference while contouring, and for mapping regions or points ofinterest between image sets.

Smart brush and smart interpolation
The image-guided smart brush and smart interpolation
facilitate contouring by snapping to image features and canhelp delineate organs and targets using only a few contours.

Model-based segmentation (MBS)MBS delineates organs automatically using statistical shapemodels for different body sites. The adaptation to new image
data utilizes a combination of greyscale gradients and shapestatistics. Multiple ROI can be delineated simultaneously,
which increases throughput, accuracy and reproducibility.

Structure templates
Structure templates allow you to create ROI withpredefined name, type and color, which allows forconsistently labeled structure sets according to yourclinic’s protocol. Structure templates may also include
geometries including density overrides for quick retrievalof support structures.

7

ROI algebraWith ROI algebra, you can create derived ROI using Boolean
expressions and margins. A derived ROI remembers its
expression and will automatically detect when it needs
to be updated. Derived ROI also go into structure templates,
saving you the time it takes to specify complex expressions.

SIMULTANEOUS PLAN EVALUATION
Several predefined layouts are available for simultaneouscomparison of dose distribution, dose statistics, clinical goals
and dose-volume histograms for up to three different plans.
Dose can be directly computed on additional image sets forevaluation. For evaluation of robustness, dose can also becomputed for a density perturbation or patient shift.

VIRTUAL SIMULATION
RayPlan offers a dedicated workspace for performing virtual simulation tasks
related to isocenter placement, export to patient marking systems, beam design
and plan export. This will smoothen your workflow prior to planning as thevirtual simulation module is integrated into RayPlan.
KEY FEATURES• Dedicated workspace for virtual simulation• One-click creation of plan with orthogonal beam pair
• Isocenter placement using DRR pair
• Export to patient marking systems• A multitude of beam-design tools for field shaping• DICOM export

8

COMMISSION, CHECK, GO
RaySearch takes pride in striving for seamless connectivity with the diverse
software and modalities involved in the treatment. We leave you the flexibility tochoose to purchase your own hardware, or having us propose cost-effective
hardware options. All to make sure we accommodate your needs and budget in
the most efficient way.
MODELINGSEAMLESS CONNECTIVITY

A dedicated graphical user interface is available for photon
and electron. This workspace allows for evaluation of models
and treatment planning tools prior to commissioning a machine.

RayPlan is compatible with most commercially available linear
accelerators, OIS and third-party QA. Its data model is fully compatible
with the DICOM standard, making it easy to import or export any
DICOM RT object. This includes multiple CT, MR and PET image series,
4D-CT, structure sets, doses and RT Plan and RT Ion treatment plans.
In addition, RayPlan communicates with other data sources, such as
IHE RO, DICOM senders and receivers and DICOM archives, using either
file transfer, DICOM storage service classes or DICOM query/retrieve.
RaySearch is involved in both the technical and planning committeesof the IHE RO, and we consider it a very high priority to work with theseorganizations and other companies in radiation oncology to assure safe
and seamless connectivity where possible.

QUALITY ASSURANCE
The module for Quality Assurance preparation makes it straightforward
to transfer the clinical plan to a phantom and recalculate dose, either
beam by beam or for the entire plan. The output from the module is thedose distribution in DICOM format or a 2D dose plane, a QA report and,optionally, a new treatment plan with collapsed gantry angles.

9HARDWARE INDEPENDENCE AND FLEXIBLE SOLUTIONS• Flexible setup; centers can choose to purchase theirown hardware• Floating licenses• Unlimited patient data storage, flexible configuration ofmultiple parallel databases and gradual archiving• Dose calculation based on GPU• Flexible deployment options that can include at-deskclients or shared-server solutions

“
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10

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MORE THAN SERVICE– A COMMUNITY
Customer satisfaction is a top priority at RaySearch. Our service department
ensures you get the best experience when using RayPlan through efficient
product delivery, high quality training and fast and effective support – all at
a local level. We listen to our customers and try our best to accommodate allenhancement requests in future versions of the software.
SMOOTH GO-CLINICAL PROCESSUSER MEETINGS

We recognize that implementing a new treatment planning systemor replacing an existing platform is not an easy task. We strive to
streamline the installation to ensure it has very little impact on thedaily work of the clinical staff. As a customer you will be assigned
a dedicated RayPlan Delivery Team consisting of three experts:
an application specialist, an IT-specialist and a physics specialist.
For each installation, we also assign a project manager who leads
the dedicated team of experts and will guide you through every
step of the process.

Customers are invited to annual user meetings in Europe, USA
or APAC. Local user meetings are also organized to allow users tocommunicate in their respective languages and discuss issues
specific to their region.
These meetings allow you to hear about the latest product news andmeet with our R&D teams to ask questions and get hands on advices.
The meetings are also a fantastic opportunity to network with users
from other clinics and to hear presentations about how they use thesoftware in their clinic.

A COMPREHENSIVE SERVICE CONTRACT
The standard service contract lets you access all new software
releases that are already licensed, completely free of charge,
ensuring you can benefit from the latest improvements as soon
as they are available. We work with you to ensure an effective
implementation of RayPlan’s advanced technologies andworkflows at your center.

RAYPLAN ONLINE COMMUNITY
Our dedicated online community gives you quick and direct accessto experts from the service team, enabling you to get your questions
answered and discuss the issues that matter to you.
The online community is also an easy way to connect with other
RayPlan users. You can ask questions, log support cases, request
enhancements and browse the knowledge database for answers tofrequently asked questions. All cases logged in the portal are investigatedby a RayPlan expert to provide the best solution to your problem
within 24 hours.

TRAINING
Training is an important part of the go-clinical process, as well as an
ongoing partnership with you and your teams to ensure you get thefull potential from our products and benefit from the latest functionality
updates. RaySearch regularly provides in-house and customized
onsite trainings in application, physics, and IT for RayPlan users.
These training courses are approved for continuous education credits
in different countries. Via the online community, you also get accessto webinars to refresh or deepen your knowledge.

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WHICH SYSTEM MEETSYOUR NEEDS?
RayPlan and RayStation comparison. This list
below covers the available features but does notdescribe the license configuration.

Features
Patient modeling
Manual and semi-automatic organ and target delineation tools
Rigid image registration and fusion tools
Model-based segmentation
Atlas-based segmentation
Plan evaluation
Dose statistics and clinical goal lists
Plan evaluation tools
Perturbed dose computation (isocenter shifts and density errors)
Robust evaluation
Photon dose calculation
Monte Carlo photon dose calculation engine
Collapsed cone photon dose calculation engine
Beam commissioning workspace with auto-modelingElectron dose calculation
Dose calculation engine using Monte Carlo
Electron planning
Forward electron treatment planning tools for electron applicators and inserts
3D-CRT planning
Manual and automatic tools to create conformal treatment using treat-and-protect, beam weighting, wedges, etc.
Direct optimization of 3D-CRT treatment parameters (leaf positions, beam weights, wedge fractions andwedge/collimator/gantry/couch angles)

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RayPlan

RayStation

Features

RayPlan

RayStation

IMRT planning
Direct optimization of step-and-shoot segment shapes and segment weights
Support for Sliding Window IMRT (dynamic MLC)
VMAT planning
Direct optimization of leaf positions and arc segment weights
Creation of single or multiple arcs
Virtual simulation
TomoTherapy
General features
QA preparation
Configurable plan reports
GPU-accelerated computing
Co-optimization of multiple beam sets
ScriptingMR-based planning
Automated planning tools and Machine learning
Adaptive radiation therapy
Particle Therapy (Proton, Carbon Ion, BNCT)

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WORK
AT
THE
SPEED
OF
THOUGHTTake clinical efficiency to new levels through smart, personalized automation.

ADVANCINGCANCER
TREATMENTAN INVESTMENT IN THE FUTURE
When you choose RayPlan, you have the option to upgrade to thefull capabilities of RayStation at any time. RayPlan gives you thefunctionality you need today, with the assurance that your futureneeds will always be covered.

RaySearch is a committed pioneer of oncology software. Since
2000, we have worked in close cooperation with leading centers
to improve life and outcomes for patients. We develop all our
products from the ground up and continuously revise every
aspect, from algorithms to user interface designs. Medical
science never stands still, and neither does RaySearch —our relentless drive to do things better leads us to ever-higher
performance, accuracy, safety and usability. And this is justthe beginning.
We believe software is the driving force for innovation in
oncology today. Our systems use groundbreaking automationand machine learning to create new possibilities. RayCare*,the next-generation oncology information system, will enable
one workflow for all the oncology disciplines, ensuring fluid
coordination of tasks and optimal use of resources. RayStation
harmonizes treatment planning, providing one point of control
for all planning needs — any equipment, any scale.
* Subject to regulatory clearance in some markets.

www.raysearchlabs.com

RayPlan Brochure 2019-12-09

ADVANCINGCANCER
TREATMENT