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Native Category:MacOS text editors Category:Windows text editors Category:FreewareA major problem with the managementof experimental autoimmune encephalomyelitis (EAE) in guinea pigs and other animals is that the data so generated are notalways reliable. Many investigators recognize the need for objective criteria, but some feel that more time is needed to learn
more about the disease and particularly about the animals which are most promising. A great deal of planning and work must go
into EAE induction and the control of it. Most major projects are defined long before any clinical evidence of disease appears.
The immunological changes which occur during the course of disease will have major implications not only for development of
new treatments but also for defining the role of vaccines. In early experiments we observed that passive EAE was very different
from that induced in animals immune, thus providing very significant data which otherwise might have been discarded asirrelevant. The present proposal will use this information in the evaluation of immunization regimens. We also observe that thepage 1 / 3

initial emphasis should be on the control of the disease rather than the induction of it. The control of disease is much easier todetermine. We plan to study the immunological changes occurring in this control and will compare them to those occurring inEAE animals. We will also modify the control by selecting only animals with major histocompatibility complexes which affectthe disease. We will be able to identify with greater certainty the effective components of the transferred lymphocytes and willfurther investigate the role of the anti-virus factor present in the lymphokine.Wet-Bulb Globe Temperature Wet-bulb globe
temperature, sometimes referred to as WBGT, is a measure of thermal stress experienced by humans in the outdoors, based on
the human body's perception of environmental conditions (temperature, humidity, wind speed, and solar radiation). It is a
derivative of the Wet Bulb Global Temperature or WBT, which is a sub-set of Wet Bulb Globe Temperature, and is an
important metric in the protection of human health (Warnock, Glynn, and Buchanan, 2001). Calculation Wet-bulb globetemperature is based on the difference between air temperature (Ta, °C) and a physically defined parameter called the wet-bulb
globe

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