Program<Friday, November 7, 2014>
12:20 – 12:30

Opening remarks
Hiroyuki Sasaki (Director, Medical Institute of Bioregulation)

Session 1: Hematopoietic stem cell and their niche
Chaired by Kei-ichi Nakayama
12:30 – 13:00

Takashi Nagasawa (Kyoto University)
The microenvironmental niches for hematopoietic stem andprogenitor cells in bone marrow

13:00 – 13:25

Yuya Kunisaki (Kyushu University)
NG2+ arteriolar pericytes form niches for dormant hematopoietic
stem cells

13:25 – 13:50

Yoshio Katayama (Kobe University)
Lympho-hematopoietic microenvironment regulated by inter-organcommunication

13:50 – 14:05

Shoichiro Takeishi (Young speaker; Kyushu University)
Disruption of quiescence by p57 ablation confers oncogene
addiction to leukemia stem cells through altered niche regulation

Session 2: Thymic microenvironment
Chaired by Yoshinori Fukui
14:10 – 14:45

Graham Anderson (University of Birmingham, UK)
Cellular and molecular regulation of the thymus medulla

14:45 – 15:10

Yoko Hamazaki (Kyoto University)
Thymic medullary epithelial stem cells ensuring lifelong central
T-cell tolerance

15:10 – 15:25

Toyoshi Yanagihara (Young speaker; Kyushu University)
Identification of a novel molecule essential for Aire expression andself-tolerance

15:25 – 15:40

Kensuke Takada（Young speaker; Tokushima University）
Thymoproteasome-dependent MHC class I-associated peptide
motifs contribute to positive selection of CD8 T cells

15:40 – 16:10

Coffee breakSession 3: Leukocyte migration
Chaired by Jens Stein
16:10 – 16:25

Sachiko Kamakura (Young speaker; Kyushu University)
Noncanonical G protein signaling regulates neutrophil chemotaxis
via the cell polarity protein mInsc

16:25 – 17:00

Michael Sixt (Institute of Science and Technology, Austria)
Cytoskeletal control of leukocyte navigation

17:00 – 17:30

Jens Stein (University of Bern, Switzerland)
Intravital imaging of naive and effector/memory T cell migration inlymphoid and non-lymphoid tissues

17:30 – 18:00

Tatsuo Kinashi (Kansai medical University)
Regulation of lymphocyte migration and immunological synapse
formation through Rap1 signaling

19:00 –Dinner party (by invitation only)<Saturday, November 8, 2014>
Session 4: Activation and regulation of leukocytes
Chaired by Kenzaburo Tani
10:00 – 10:20

Yoshinori Fukui (Kyushu University)
Critical roles of DOCK family proteins in migration and activationof leukocytes

10:20 – 10:50

Hajime Karasuyama (Tokyo Medical and Dental University)
Basophils have emerged as a key player in immunity

10:50 – 11:10

Sho Yamasaki (Kyushu University)
Immune regulation through C-type lectin receptors

11:10 – 11:25

Markus Ackerknecht (Young speaker; Bern University)
Dual role of DOCK2 for efficient CD4+ T cell – dendritic cellinteractions in vivo

11:25 – 11:55

Akihiko Yoshimura (Keio University)
Molecular basis for the induction of regulatory T cells bygram-positive bacteria and TGF-β in the intestine11:55 – 12:15

Group photos

12:15 – 14:00

Lunch and poster presentation by young researchers

Session 5: Inflammation and diseases
Chaired by Sho Yamasaki
14:00 – 14:35

Paul Kubes (University of Calgary, Canada)
The dynamic immune response in sterile inflammation

14:35 – 14:50

Hirokazu Nakatsumi (Young speaker; Kyushu University)
Nutrition
signalinduces
inflammationvia
mTOR-FOXK1-CCL2 pathway

the14:50 – 15:20

Naoko Ohtani (Tokyo University of Science)
Obesity-induced gut microbial metabolite promotes liver cancer
through senescence-associated secretome

15:20 – 15:35

Masatsugu Oh-hora (Young speaker; Kyushu University)
Calcium signaling in chronic inflammation

15:35 – 16:05

Shigeo Koyasu (RIKEN Center for IMS)
Role of natural helper cells, a member of group 2 innate lymphoidcells (ILC2), in allergic inflammation

16:05 – 16:35

Coffee break

Session 6: Special lecture
Chaired by Takehiko Sasazuki
16:35 – 17:20

Mark M. Davis (Stanford University, USA)

17:20 – 17:30

Closing remarks
Takehiko Sasazuki (Kyushu University)