2011 年度 DMPK 三賞決定
日本薬物動態学会会長

編集委員長

乾賢一

玉井郁巳

2011 年度 DMPK 三賞が決定しましたのでお知らせします。最優秀論文賞およびベストサイテーション賞の第一位の論文（総説、原著論文）について、第 26 回年会時に授賞式を行います。

1.

編集委員が選ぶ最優秀論文賞(DMPK Editors’ Award for the Most Excellent Article in 2010)【1st Place】
著者，所属: Tomoko SUGIURA1), Toru OTAKE1), Takuya SHIMIZU1), Tomohiko WAKAYAMA2), David L.
SILVER3), Rie UTSUMI1), Tomohiro NISHIMURA1), Shoichi ISEKI2), Noritaka NAKAMICHI1), Yoshiyuki
KUBO1), Akira TSUJI1) and Yukio KATO1)(1) Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences, Graduate School of
Medical Science, Kanazawa University,2) Department of Histology and Embryology, Graduate School of
Medical Science, Kanazawa University,3) Department of Biochemistry, Albert Einstein College of Medicine）
論文題目：PDZK1 Regulates Organic Anion Transporting Polypeptide Oatp1a in Mouse Small Intestine. Drug

Metabolism and Pharmacokinetics 25(6), 588-598 (2010)【2nd Place】
著者，所属：Arief NURROCHMAD1), Yuji ISHII1), Hitomi NAKANOH1), Tae INOUE3), Toru HORIE3),Kazumi SUGIHARA4), Shigeru OHTA4), Akinobu TAKETOMI2), Yoshihiko MAEHARA2) and Hideyuki
YAMADA1)（1) Laboratory of Molecular Life Sciences, Graduate School of Pharmaceutical Sciences, Kyushu University,2)Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University,3) PhoenixBio.
Co., Ltd. ,4) Graduate School of Biomedical Sciences, Hiroshima University）
論文題目：

Activation of Morphine Glucuronidation by Fatty Acyl-CoAs and Its Plasticity: A Comparative

Study in Humans and Rodents Including Chimeric Mice Carrying Human Liver. Drug Metabolism andPharmacokinetics 25(3),262-273 (2010)【3rd Place】
著者，所属： Wataru SATO1), Hiroyuki SUZUKI1),Takamitsu SASAKI1), Takeshi KUMAGAI1), Shuhei
SAKAGUCHI1), Michinao MIZUGAKI2), Shinichi MIYAIRI3), Yasushi YAMAZOE4) and Kiyoshi NAGATA1)（1) Department of Environmental and Health Science, Tohoku Pharmaceutical University,2) Department ofClinical Pharmaceutics, Tohoku Pharmaceutical University,3) Laboratory of Bio-organic Chemistry, Collegeof Pharmacy, Nihon University,4) Division of Drug Metabolism and Molecular Toxicology, Graduate School

of Pharmaceutical Sciences, Tohoku University）
論文題目： Construction of a System that Simultaneously Evaluates CYP1A1 and CYP1A2 Induction in aStable Human-derived Cell Line using a Dual Reporter Plasmid. Drug Metabolism and Pharmacokinetics
25(2), 180-189(2010)2.

ベストダウンロード論文賞(DMPK Award for the Most Frequently Downloaded Article in 2009)
1)

Review Article【1st Place】
著者，所属：Hiroyuki KUSUHARA and Yuichi SUGIYAMA（Graduate School of Pharmaceutical Sciences, The University of Tokyo）
論文題目：

In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney. DrugMetabolism and Pharmacokinetics 24(1), 37-52(2009)【2nd Place】
著者，所属：Masoud JAMEI1), Gemma L DICKINSON2) and Amin ROSTAMI-HODJEGAN1)3)（1) Simcyp Limited,2) Eli Lilly,3) Academic Unit of Clinical Pharmacology, University of Sheffield）
論文題目：A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual

Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiologyand Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates. Drug Metabolism andPharmacokinetics 24(1), 53-75(2009)【3rd Place】
著者，所属：Donald E. MAGER, Sukyung WOO and William J. JUSKO（ Department of Pharmaceutical Sciences, University at Buffalo, State University of New York）
論文題目： Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans. DrugMetabolism and Pharmacokinetics 24(1), 16-24(2009)2)

Original Article【1st Place】
著 者 ， 所 属 ： Nobuo SEKIGUCHI1), Atsuko HIGASHIDA2), Motohiro KATO1), Yoshiaki NABUCHI1),Tetsuya MITSUI1), Kenji TAKANASHI1), Yoshinori ASO1) and Masaki ISHIGAI1)（1) Pre-Clinical Research Department, Chugai Pharmaceutical Co., Ltd.,2) Discovery Platform Technology
Department, Chugai Pharmaceutical Co., Ltd.）
論文題目： Prediction of Drug-Drug Interactions based on Time-Dependent Inhibition from High Throughput
Screening of Cytochrome P450 3A4 Inhibition. Drug Metabolism and Pharmacokinetics 24(6), 500-510(2009)

【2nd Place】
著者，所属： Masuhiro NISHIMURA1), Satoshi SUZUKI2), Tetsuo SATOH2) and Shinsaku NAITO1)(1) Research and Development Center, Otsuka Pharmaceutical Factory, Inc.,2) Non-Profit Organization
Human & Animal Bridging Research Institute, Ichikawa General Hospital）
論文題目： Tissue-Specific mRNA Expression Profiles of Human Solute Carrier 35 Transporters. Drug

Metabolism and Pharmacokinetics 24(1), 91-99(2009)【3rd Place】
著者，所属： Mikihisa TAKANO, Yoshifumi OTANI, Minori TANDA, Masashi KAWAMI 1), Junya NAGAI andRyoko YUMOTO( Department of Pharmaceutics and Therapeutics, Graduate School of Biomedical Sciences, Hiroshima
University）
論 文 題 目 ：Paclitaxel-resistance Conferred by Altered Expression of Efflux and Influx Transporters forPaclitaxel in the Human Hepatoma Cell Line, HepG2. Drug Metabolism and Pharmacokinetics 24(5),418-427(2009)3.

ベストサイテーション論文賞(DMPK Award for the Most Frequently Cited Article in 2007)
1)

Review Article【1st Place】
著者，所属：Shigeru KAWAKAMI and Mitsuru HASHIDA( Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University）
論 文 題 目 ： Targeted Delivery Systems of Small Interfering RNA by Systemic Administration.

DrugMetabolism and Pharmacokinetics 22(3), 142-151(2007)【2nd Place】
著者，所属：Kazuhide IWASAKI（Department of Pharmacokinetics Dynamics Metabolism, Pfizer Global Research Development, NagoyaLaboratories, Pfizer Japan Inc.）論 文 題 目 ： Metabolism of Tacrolimus (FK506) and Recent Topics in Clinical Pharmacokinetics. DrugMetabolism and Pharmacokinetics 22(5),328-335(2007)【3rd Place】
著者，所属：Kiyohiko SUGANO, Arimichi OKAZAKI, Shohei SUGIMOTO, Sumitra TAVORNVIPAS, Atsushi
OMURA and Takashi MANO
（Global Research & Development, Nagoya Laboratories, Pharmaceutical R&D, Pfizer Inc.）論 文 題 目 ： Solubility and Dissolution Profile Assessment in Drug Discovery. Drug Metabolism andPharmacokinetics 22(4), 225-254(2007)2)

Original Article【1st Place】
著 者 ， 所 属 Masuhiro NISHIMURA1), Akiko KOEDA2), Yasuyuki SUGANUMA2), Emako SUZUKI2),
Takefumi SHIMIZU2), Mitsuo NAKAYAMA1), Tetsuo SATOH2)3), Shizuo NARIMATSU4) and Shinsaku
NAITO1)(1) Department of Drug Metabolism, Division of Pharmacology, Drug Safety and Metabolism, Otsuka
Pharmaceutical Factory, Inc.,2) Ina Research Inc.,3) Non-Profit Organization Human & Animal Bridging
Research Organization,4) Laboratory of Health Chemistry, Graduate School of Medicine, Dentistry andPharmaceutical Sciences, Okayama University）
論文題目：Comparison of Inducibility of CYP1A and CYP3A mRNAs by Prototypical Inducers in Primary
Cultures of Human, Cynomolgus Monkey, and Rat Hepatocytes. Drug Metabolism and Pharmacokinetics
22(3), 178-186(2007)【2nd Place】
著 者 ， 所 属 ： Yoshiteru KAMIYAMA1)2), Tsutomu MATSUBARA1)3), Kouichi YOSHINARI1), Kiyoshi
NAGATA1)4), Hidetaka KAMIMURA2) and Yasushi YAMAZOE1)3)(1) Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences,
Tohoku University,2) Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas PharmaInc.,3) Tohoku University 21st Century, COE Program “Comprehensive Research and Education Center for
Planning of Drug Development and Clinical Evaluation”,4) Department of Environmental Health Science,
Tohoku Pharmaceutical University）
論文題目： Role of Human Hepatocyte Nuclear Factor 4α in the Expression of Drug-Metabolizing Enzymes
and Transporters in Human Hepatocytes Assessed by Use of Small Interfering RNA. Drug Metabolism andPharmacokinetics 22(4), 287-298(2007)【3rd Place】
著者,所属：Koki KOJIMA, Kiyoshi NAGATA, Tsutomu MATSUBARA and Yasushi YAMAZOE（Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, TohokuUniversity）
論文題目： Broad but Distinct Role of Pregnane X Receptor on the Expression of Individual Cytochrome P450s
in Human Hepatocytes. Drug Metabolism and Pharmacokinetics 22(4), 276-286(2007)