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External links Category:Computer programming toolsNIH Uncovers Roles for Small RNA in Regulating Gene Expression JohnM. Bishop and colleagues at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) have identified four
distinct modes of small-RNA-based regulation, which the researchers say may be a new mechanism for controlling gene
expression in the body. These modes can be viewed as guidelines that the cell follows to find and interpret small RNAs thattarget gene-expression control elements and silence those genes. The research, “RNA-Guided Gene Expression Regulation,” ispublished online in the July 16 issue of the journal Cell. The study, the first to elucidate three previously unrecognized smallRNA-guided gene-expression regulatory modes, was led by Peter F. Vogel at the National Cancer Institute, and co-led by
Melissa A. Tomes, a graduate student at the Rockefeller University, and Jonathan A. Weissman, a research scientist at theNIDDK. “Our study helps explain the remarkable ability of RNAi to regulate and change the expression of genes at themolecular level,” says Bishop, the lead author. RNAi is one form of gene silencing, and is frequently used in the laboratory tostudy gene function. Gene silencing involves the process in which small RNA molecules, called short interfering RNAs, orsiRNAs, bind to specific regions of genes that control their expression, thereby preventing the expression of certain proteins thatare encoded by that gene. Before the work by Bishop and colleagues, the study of siRNA-based gene regulation was limited to
two modes: forward gene-regulation silencing, by which siRNA targets the gene-expression control element itself; and antisensegene-regulation silencing, in which the gene-expression control element is silenced by the binding of an antisense siRNA to adifferent, complementary region of the gene. “These two modes are but a few degrees removed from a perfect textbook
example of the type of regulation that is seen in nature,” says Tomes. “When two complementary complementary binding
partners of the same strand of RNA bind, they are locked into an inactive state or, as the case may be, they can potentiallyunwind the molecule and allow for the production of new RNA, which will be complementary to the other binding partner.”
Using a method that Bishop and colleagues developed earlier, theyDownload

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produced by the body's endogenous respiration, e.g. carbon dioxide, may also play a role in the etiology of pulmonary disorders.
The origin of exhaled carbon dioxide, its physiological characteristics, as well as the effect of this gas on the human body, areherein presented, as also are the methods of its measurement. This article reviews the background and recent literature in thestudy of exhaled carbon dioxide. Some common misconceptions in the literature regarding the physiology of carbon dioxide arecorrected. Conclusions: Exhaled carbon dioxide is a highly potent stimulus for the active expiration reflex in man and can beused for the rapid detection of respiratory disturbances. This novel quantitative method can be used as an additional therapeuticmeasure to improve clinical symptoms and as a clinical test for monitoring asthma patients.Marvel’s Jessica Jones to Begin
Filming This Winter UPDATE: 16 April 2016, 6.59pm: Based on the latest job listing spotted by Screen Rant (via BleedingCool), it sounds like Marvel’s Jessica Jones will begin filming this winter. CBS has officially announced that it will be airing
Marvel’s Jessica Jonesin early 2017. Actress Krysten Ritter will be reprising the role of the Marvel’s Luke Cage Jessica Jones inan upcoming episode of Iron Fist season 2. – Starring Academy Award winner Jessica Jones, Ritter made a powerful impact as arebellious teen on Marvel’s Daredevil. Since then, the character has gone on to appear in Ant-Man, her own series that’s
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