徐維莉 Hsu, Wei-Li
Hsu, Wei-Li
Distinguished Professor
Professional Specialty: Molecular Virology, Pathogenesis, Laboratory Diagnosis
Tel: 04-22840695
E-mail: wlhsu@dragon.nchu.edu.tw
Education background & professional career:
1998-2002
1995-1997
1991-1995

Ph.D. MRC Virology Unit, University of Glasgow (Scotland, UK)
M.Sc. Graduate Institute of Veterinary Microbiology, National Chung-Hsing University (Taiwan)
B.V.M Department of Veterinary Medicine, National Chung-Hsing University (Taiwan)

2014 (Feb-Aug) visiting scholar in Prof. Peter Palese Lab (Icahn School of Medicine at Mount Sinai, USA)
2004 - 2005 Postdoctoral research fellow (University of Cambridge, UK)2002 - 2004 Postdoctoral research fellow (Department of MMI, University of Alberta, Canada)

Honours:
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Overseas Research Student Award (ORS), UK: 1998-2001
Scholarship for Postgraduate Students (University of Glasgow):1998-2001
The outstanding young faculty of National Chung-Hsing University (2010, 2011)
Distinguished Professor, National Chung-Hsing University (2015-now)

Researches：
The major researches in my lab:
1. Avian Influenza viruses (AIVs) cause severe diseases in poultry worldwide. We aimed to investigate the impact of theviral NS1 protein on viral infection dynamics. By exchange of the NS segment, the replication of reassortant AIVs wassignificantly affected and that is significantly related with the modulatory effect of NS1 on host anti-viral responses andviral RdRp activity. These results indicate that NS1 is a critical factor responsible for the diverse traits of AIVs in Taiwan.
2. Orf virus (ORFV), a parapoxvirus, causes endemic disease in goats. Since 2007, we initiated the ORFV studies, not onlyin molecular epidemiology but also in the pathogenesis aspect. In particular, we revealed the function and mechanism ofOV20.0 protein on counteracting innate immune response and suppresses sing RNA interference machinery. Extending
from the understanding of its distinct immune regulatory effect, we are currently exploring the oncolytic activity of ORFVin several cancer models.
3. Development of methods & identification of biomarkers for diagnosis of animal cancers and renal diseases.
Selected publication (2017-2021): * corresponding author. #Co-first author
1. Chen, Y.C., W.Y. Chin, C.C. Chang, S.T. Chuang, and W.L. Hsu*. 2021. Potential Risk Factors Associated with Infection
with Bovine Leukaemia Virus in Dairy and Beef Cattle in Taiwan. Pathogens 10(12): 1553
4. Liao, G.R., Y.Y. Tseng, C.Y. Tseng, C.Y. Lo, W.L. Hsu*. 2021. The orf virus (ORFV) protein OV20.0 interacts withthemicroprocessor complex subunit DGCR8 to regulatemiRNA biogenesis and ORFV infection. FEBS Letters. 595 (2021)
2897-2908. (IF: 4.124)
5. Tseng,Y.Y., C.Y. Kuan, M. Mibayashi, C.J.Chen, P. Palese, R. A. Albrecht, W.L. Hsu*. 2021. Interaction between NS1
and cellular MAVS contributes to NS1 mitochondria targeting. Viruses.13: 1909. (IF: 5.079)
6. M.H. Liao, X.R. Wang, W.L. Hsu*, Jason T.C. Tzen*. 2021. Pu'er tea rich in strictinin and catechins prevents biofilm
formation of two cariogenic bacteria, Streptococcus mutans and Streptococcus sobrinus. Journal of Dental Sciences.
Accepted in May 25. 2021. (IF: 2.08)
7. Lin, H.W., Y.J. Lee, D.J. Yang, M.C. Hsieh, C.C. Chen, W.L. Hsu, Y.Y. Chang*, C.W. Liu*. 2021. Anti-inflammatory
effects of Flos Lonicerae Japonicae Water Extract are regulated by the STAT/NF-κB pathway and HO-1 expression inVirus-infected RAW264.7 cells. Int J Med Sci. Mar 30;18(11):2285-2293. (IF 5.923)
8. Liao, G.R., Y.Y. Tseng, C.Y. Tseng, Y.P. Huang, C.H. Tsai, H.P. Liu, W.L. Hsu*. 2021. K160 in the RNA-binding domainof the orf virus virulence factor OV20.0 is critical for its functions in counteracting host antiviral defense. FEBS Letters.
595: 1721-1733. (IF: 4.124)

9.

Tseng, Y.Y., G.R. Liao, A. Lien, and W.L. Hsu*. 2021. Current concepts in the development of therapeutics against humanand animal coronavirus diseases by targeting NP. Computational and Structural Biotechnology Journal 19 (2021) 10721080. (IF:7.271)
10. Jiang, M.C., C.C. Hu, W.L. Hsu, T.L. Hsu, N.S. Lin and Y.H. Hsu*. 2020. Fusion of a Novel Native Signal Peptide
Enhanced the Secretion and Solubility of Bioactive Human Interferon Gamma Glycoproteins in Nicotiana benthamiana
Using the Bamboo Mosaic Virus-Based Expression System. Front. Plant Sci. Nov, 11:594758. (IF: 5.753)
11. Lin, P.R., P.C. Kuo, Y.C. Lia, C.F. Jhuo, W.L. Hsu*, Jason T.C.Tzen*. 2020. Theacrine and strictinin, two major
ingredients for the anti-influenza activity of Yunnan Kucha tea. Journal of Ethnopharmacology November, 262: 113190.
12. Guntawang, T., T. Sittisak, S. Srivorakul1, V. Kochagul, K. Photichai, C. Thitaram, N. Sthitmatee, W.L. Hsu & K.
Pringproa. 2020. In vivo characterization of target cells for acute elephant endotheliotropic herpesvirus (EEHV) infectionin Asian elephants (Elephas maximus). Scientific Reports. July 10:11402. (IF: 4.379)
13. Jing, H.#, W.L. Hsu#,V. Wu, H.J. Tsai, S.F. Tsai, P. S Tsai, T. S. Lai, and Y.J. Lee*. 2020. Urine hemojuvelin in cats withnaturally occurring kidney diseases. Journal of Veterinary Internal Medicine. May 34(3):1222-1230.(IF: 3.33)
14. Chen, Y.C., C.C. Chang, W.L. Hsu*, and S.T. Chuang*.2020. Dairy cattle with bovine leukaemia virus RNA show
significantly increased leukocyte counts. Veterinary Journal 257:105449. (IF: 2.688)
15. Wang W.C., C.Y. Kuan, Y.J. Tseng, C.H. Chang, Y.C. Liu, Y.C. Chang, Y.C. Hsu, M.K. Hsieh, S.C. OU*, W.L. Hsu*.
The Impacts of Reassortant Avian Influenza H5N2 Virus NS1 Proteins on Viral Compatibility and Regulation of Immune
Responses. 2020. Frontiers in Microbiology. Mar.12; 11:280. (IF: 5.64)
16. Lin, T.L#, S.C. Ou#, K. Maeda, H. Shimoda, Jacky P.W. Chan, W.C. Tu, W.L. Hsu* and C.C. Chou*. 2020. The First
Discovery of Severe Fever with Thrombocytopenia Syndrome Virus in Taiwan. Emerging Microbes and infections. 9: 148151. (IF: 7.163)
17. Chen, YC., J.W. Liao, S.C. Chang, and W.L. Hsu*. 2020. Expression frequency of c-kit isoforms and its prognostic
potential in canine mammary Tumours. Veterinary and Comparative Oncology. Sep;18:303-314. (IF: 2.613)
18. Hsieh#, J.C. C.Y. Li#, W.L. Hsu*, S.T. Chuang*. 2019 Dec. Molecular epidemiological and serological studies of Bovine
Leukemia Virus in Taiwan. Frontiers in Vet Sci.6: 427. (IF: 3.412)
19. Yamada Y., G.R. Liao1, C.Y. Tseng., Y.Y. Tseng, W.L. Hsu*. 2019 Establishment and characterization of transformed
Goat Primary cells by expression of Simian Virus 40 Large T Antigen for orf virus propagations. PLOS One Dec
5;14(12):e0226105 (IF 3.240)
20. Wu, P.H#., W.L. Hsu#, P.S. Jason Tsai, V.C. Wu, H.J. Tsai, Y.J. Lee. 2019 Identification of urine neutrophil gelatinaseassociated lipocalin molecular forms and their association with different urinary diseases in cats. BMC Vet Res. 15: 306.
21. Chen, YC., S.C. Chang, Y.H. Huang, Y.J. Lee, C.C. Chang, J.W. Liao, and W.L. Hsu*. 2019 Expression and the molecularforms of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase 9 in canine mammary tumors. Veterinaryand Comparative Oncology. 17(3):427-438. (IF: 2.613)
22. Liao, G.R., Y.Y. Tseng, C.Y. Tseng, F.Y. Lin, Y. Yamada, H.P. Liu, C.Y. Kuan, W.L. Hsu*.2019. Adenosine Deaminase
Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication. J. Virology. 93:e01912-18.
23. Richart, S. M.#, Y.L. Li#, Y. Mizushina, Y.Y. Chang, T.Y. Chung, G.H. Chen, J. T.C. Tzen, K.S. Shia and W.L. Hsu*.
2018. Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection.
JFDA. 26:1015-1023. (IF: 6.079)
24. Dony Mathew, Wei-Li Hsu*. 2018 Antiviral Potential of Curcumin. Journal of Functional Foods 40: 692-699. (IF: 4.451)
25. Tsai, CF, H.Y. Lin, WL Hsu* and CH Tsai*. 2017. The novel mitochondria localization of influenza A virus NS1
visualized by FlAsH labelling. FEBS OpenBio. 7(12): 1960-1971. (IF 2.6963)
26. Chen JM, Fan YC, Lin JW, Chen YY, Hsu WL, Chiou SS. 2017. Bovine Lactoferrin Inhibits Dengue Virus Infectivity byInteracting with Heparan Sulfate, Low-Density Lipoprotein Receptor, and DC-SIGN. International Journal of Molecular
Science 18(9). pii: E1957. (IF 5.923)
27. Li, TH., WL Hsu, YC Lan, G.H. Balazs, T. M. Work, C.T. Tseng, C.C. Chang*. 2017. Identification of Chelonid
herpesvirus 5 (ChHV5) in endangered green turtles (Chelonia mydas) with fibropapillomatosis in Asia. Bulletin of Marine
Science 93(4) 1011-1022. (IF:1.632)
28. Wang, I.C#., W.L. Hsu#, P.H. Wu, H.Y. Yin, H.J. Tsai, Y.J. Lee. 2017 Neutrophil Gelatinase-Associated Lipocalin in Catswith Naturally Occurring Chronic Kidney Disease. Journal of Veterinary Internal Medicine 31(1):102-108.

Patterns:1.
2.

Novel Enterococcus faecium LJS-01 and its use for probiotic (No I-417054), 2013, Taiwan
Tumor specific antigen, recombinant protein, antibody, and primer thereof, and the method for identifying mammaliantumors, 2016, Taiwan.

Updated: 2022/03/01