September 22nd, 20072008 Prohibited List
Summary of Major Modifications
SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- ANDOUT-OF-COMPETITION)
S1. Anabolic Steroids
1- Anabolic Androgenic steroids•The concept of “atypical” result has been introduced in the explanatory textof this section:
1- In the fourth paragraph, two additional sentences have been added toestablish that if an initial result for an endogenous anabolic steroid
triggers additional investigations in order to determine the endogenous
or exogenous origin of the substance, then the sample should bereported as “atypical” instead of an “Adverse Analytical Finding”. This
concept of “atypical” result is incorporated as follows: "When such aninvestigation is required, the result shall be reported by the laboratory
as atypical and not as adverse." and "The result that triggered thislongitudinal study shall be reported as atypical".
2- The phrase “and an Adverse Analytical Finding will be reported” hasbeen added to the first sentence of the first paragraph to indicate that
this definition applies to a result that is not considered “atypical” and it
has been proven to represent an Adverse Analytical Finding.

•Several sentences in the explanatory text have been deleted and text
modifications have been introduced to avoid redundancies. In this regard:
1- The phrase “in order to determine whether the result is due to aphysiological or pathological condition, or has occurred as a consequenceof the exogenous origin of a Prohibited Substance” has been deleted
from the third paragraph and the concept has been summarized inchanges introduced to the first sentence of the third paragraph: “When avalue does not so deviate from the range of values normally found in
humans and any reliable analytical method…….”.

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2- The phrase “When a laboratory has reported a T/E ratio greater thanfour (4) to one (1) and any reliable analytical method (e.g. IRMS)
applied has not determined the exogenous origin of the substance,
further investigation may be conducted by a review of previous tests orby conducting subsequent test(s), in order to determine whether theresult is due to a physiological or pathological condition, or has occurred
as a consequence of the exogenous origin of a Prohibited Substance.”
has been deleted from the fourth paragraph of the 2007 List andsummarized in the first sentence of the third paragraph as “……. or whena laboratory has reported a T/E ratio greater than four (4) to one (1)and any reliable analytical method (e.g. IRMS) has not determined theexogenous origin of the substance,”.
3- The last sentence of the fifth paragraph of the 2007 List “When anadditional reliable analytical method (e.g. IRMS) has not been appliedand a minimum of three previous test results are not available, alongitudinal profile of the Athlete shall be established by performing aminimum of three no advance notice tests in a period of three months
by the relevant Anti-Doping Organization. If the longitudinal profile of
the Athlete established by the subsequent tests is not physiologicallynormal, the result shall be reported as an Adverse Analytical Finding.”
has been deleted because this information is now redundant withprevious paragraphs.
2 - Other anabolic agents•The Selective androgen receptor modulators (SARMs) have been
included in this section. This novel family of nonsteroidal molecules hasbeen identified as being selective and specific for the androgen receptor.
Therapeutic SARMs are currently being developed for the treatment ofmuscle wasting diseases and androgen replacement therapies. Basedupon their mechanisms of action and early clinical results in humans,
these compounds have the potential to be used as doping substances.

S2. Hormones and Related Substances•

To be consistent with the presentation of the other sections, theintroductory sentence was split in two before and after the list ofexamples.

•It is noted that LH and hCG are just 2 examples of Gonadotrophins byadding “e.g.”•

An “s” has been added to Insulin to reflect the availability of long andshort acting types of insulin.

2•The last paragraph of the section has been deleted to avoid
redundancies with “including other substances with similar chemical
structure or similar biological effect(s)”.

S4. Hormones Antagonists and Modulators•

In order to broaden the spectrum of new substances that antagonize
and/or modulate hormone receptors, the title of the S4 section, formerly“Agents with Anti-Estrogenic activity” has been changed to “Hormone
Antagonists and Modulators”.

•Agents modifying myostatin functions, which can antagonize and/or
modulate the effects of myostatin or its signalling pathways (e.g.
myostatin inhibitors) have been added to this section.

PROHIBITED METHODS
M2. Chemical and Physical Manipulation•

Based on comments from stakeholders, the wording has been changed
in order to clarify that the method can be used only in an acute medicalsituation. The intervention has to be justified by obtaining a retroactive
Therapeutic Use Exemption.

SUBSTANCES PROHIBITED IN PARTICULAR SPORTS
P1. Alcohol• At the request of the CMSB (Boules), this Federation is removed fromthis section.
P2. Beta-blockers•

At the request of the UIM, Powerboating is included in this List, as it isconsidered that these drugs can be used to enhance performance in thisparticular sport.

SPECIFIED SUBSTANCES•

It is clarified that the beta-2-agonist clenbuterol is listed in the S1.2
section as Other Anabolic Agents.

3•Alpha reductase inhibitors (e.g. finasteride, dutasteride) are now
considered Specified Substances. Although these drugs can be used asmasking agents for androgenic steroids, recent research data
demonstrate that there are analytical ways to determine whether they
have been used in conjunction with steroids by detailed analysis of theandrogenic steroid profile.

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