Prohibited List 2005
Summary of Modifications vis-à-vis 2004 Prohibited ListGeneral Introduction-For consistency with other WADA International Standards, a message on the front page states that theEnglish version will be the reference version in case of conflict.

-An educational message is provided at the beginning of the List: "The use of any drug should be limited to
medically justified indications".

-The organization of the 2005 Prohibited List has been modified:•"Substances and Methods prohibited at all times (In- and Out-of-Competition)" are now presented inSection I. Section II lists "Substances and Methods prohibited In-Competition", and consists of all thecategories listed in the previous section, plus four additional ones. Sections III and IV remain with thesame headings. The numbering of categories inside each section has been modified accordingly.

•The headings now appear as noted below:

I.

Substances and Methods prohibited at all times (In- and Out-of-Competition).
S1. Anabolic Agents
S2. Hormones and related substances
S3. Beta-2 agonists
S4. Agents with anti-estrogenic activity
S5. Diuretics and other Masking Agents

M1. Enhancement of oxygen transfer
M2. Chemical and physical manipulation
M3. Gene doping

II. Substances and Methods prohibited In-Competition.
All the Categories under Section I, plus:
S6. Stimulants
S7. Narcotics
S8. Cannabinoids
S9. Glucocorticosteroids
III. Substances prohibited in Particular Sports.
P1. Alcohol
P2. Beta-blockers
IV. Specified Substances.
•Specific changes in sections, categories, substances or methods are provided below.

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Comments regarding specific sections, categories, substances and methods
I.

SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES (IN- AND OUT-OF-COMPETITION)PROHIBITED SUBSTANCES
S1. Anabolic agents
1. Anabolic androgenic steroids
a. Exogenous-

Nine substances have been added to the list of examples: 18α–homo-17ß-hydroxyestr-4-en-3-one,calusterone, delta1-androstenediol, ethylestrenol, furazabol, methyldienolone, methyltrienolone,norclostebol, tetrahydrogestrinone.

-

The substances androstadienone and drostanediol (5-alpha androstane 3-beta, 17-beta diol) havebeen removed from the list of examples.

-The term "biological" replaces "pharmacological".

b. Endogenous-

The list of endogenous steroids is now a closed list, meaning that all known prohibited endogenous
steroids are listed and prohibited.

-The main endogenous steroids are listed first, followed by their metabolites and isomers. The intakeof these substances is either associated to performance enhancement or to alteration of urinary
steroid profiles used for the detection of doping.

-The T/E ratio has been changed to four (4) to one (1). This threshold is thus harmonized with thethreshold mentioned in the Technical Document for Laboratories. It should be noted that a T/E ratio
higher than the threshold leads to further investigation by the Anti-Doping Organization, and notnecessarily to a sanction.

-A sentence has been added to the paragraph on the T/E ratio to clarify the fact that no further
investigation is needed if the "laboratory reports an Adverse Analytical Finding based on any reliable
analytical method [for instance IRMS], showing that the Prohibited Substance is of exogenousorigin".

2. Other anabolic agents
S2.

A partial list of examples is provided for this category and includes Zilpaterol.
Hormones and related substances-The term "biological" replaces "pharmacological".

-Mechano growth factors (MGFs) have been added as an example in the sub-category of growth
hormones.

-Substances that were previously prohibited "in men only" are now prohibited for all athletes (menand women).

-The two subcategories of gonadotrophins are merged.

S3.

Beta-2 agonists-All beta-2 agonists are now prohibited in- and out-of-competition.

-As in 2004, four inhaled beta-2 agonists, namely formoterol, salbutamol, salmeterol and terbutaline,
can be used with an abbreviated TUE.

S4.

Agents with anti-estrogenic activity-This category has been divided into subsections as follows:1.
Aromatase inhibitors;
2.
Selective estrogen receptor modulators (SERMs);
3.
Other anti-estrogenic compounds.

-Substances that were previously prohibited "in men only" are now prohibited for all athletes (menand women).

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-S5.

A partial list of examples is provided for each category. New examples added to this category
include: anastrozole, letrozole, aminogluthetimide, formestane, testolactone, raloxifene, toremifene,
fulvestrant.
Diuretics and other masking agents-

The title of this category has been modified to specifically mention Diuretics.

-Examples of masking agents now include albumin.

-Alpha-reductase inhibitors (finasteride, dutasteride) have been added as masking agents.

-

Mersalyl has been removed and Metolazone has been added as an example of a diuretic.

PROHIBITED METHODS
M1.

Enhancement of oxygen transfer-

The wording has been slightly modified.

M2.

Chemical and physical manipulation-

The term "Pharmacological" has been removed in the heading of category M2. All substances
previously included in the M2 category are now included in the "Diuretics and other Masking Agents"category.

-Intravenous infusions are now prohibited as a doping method. Prohibition of intravenous infusions isnot aimed at preventing their use for legitimate acute medical purposes. Therefore an explanatory
sentence has been added to clarify this point.

M3.
-Gene doping
The wording now takes into account the modulation of gene expression as a doping practice.

II. SUBSTANCES AND METHODS PROHIBITED IN-COMPETITION-Categories S1 to S5 and M1 to M3, listed in the previous section, are prohibited in competition.
Additional categories prohibited in-competition include:

PROHIBITED SUBSTANCES
S6.

Stimulants-Fencamine and Famprofazone have been added to the list of examples.

-A note clarifying the status of adrenaline has been added.

-

Bupropion has been introduced in the Monitoring Program.

S7.
-

Narcotics
Fentanyl and its derivatives have been added to the List of substances prohibited in this closed
category.

S8.

Cannabinoids-No changes.

S9.
-

Glucocorticosteroids
Same status as in the 2004 Prohibited List, except that dermatological preparations ofglucocorticosteroids are no longer prohibited (no TUE required).

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III. SUBSTANCES PROHIBITED IN-PARTICULAR SPORTS
P1.
-Alcohol
Four Federations have requested that alcohol be removed as a substance prohibited in their sport:
Gymnastics (FIG), Roller Sports (FIRS), Triathlon (ITU) and Wrestling (FILA). Six Federations haveagreed to a harmonized threshold of 0.10 g/L of alcohol in blood, and three Federations require aspecific threshold.

P2.

Beta-blockers-No changes

P3.

Diuretics-This category, prohibiting granting of a Therapeutic Use Exemption (TUE) for Diuretics in weightclassified categories, has been removed.

IV. SPECIFIED SUBSTANCES-Diuretics have been removed from the list of Specified Substances.

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