The 59 th Fujihara International Seminar

Time Table
Wednesday
July 14

Thursday
July 15

1011Saturday
July 17

7:30 - 8:30
Business meeting of JSPS
Core-to-Core Program

89Friday
July 16

9:00 - 9:30
Opening Remarks /Introductory
9:30 - 14:30
Session 1
Molecular mechanisms ofTGF-β family signaling
Chair: Carl-Henrik Heldin

9:00 - 12:00
Session 3
TGF-β signaling and vascular,bone, and other diseases
Chair: Rik Derynck

9:00 - 12:00
Session 4
Implications in
TGF-β-based therapies
Chair: Seong-Jin Kim

9:00 - 10:30

9:00 - 10:30

Rik DerynckHideyuki Beppu
Ye-Guang Chen

Seong-Jin Kim
S. Paul Oh
Makoto Mark Taketo

Carl-Henrik Heldin
Mitsuyasu Kato

10:30 - Poster Viewing /11:00 Coffee Break

10:30 - Poster Viewing /11:00 Coffee Break

10:30 - Poster Viewing /11:00 Coffee Break

11:00 - 12:00

11:00 - 12:00

Akiko HataPeter ten Dijke

Atsushi Hirao
HQ Han9:30 - 10:30

11:00 - 12:30

Aristidis Moustakas
Keiji Miyazawa
Xin-Hua Feng

12

12:00 - 13:30
Group Photo / Lunch

12:30 Lunch / Departure

12:30 - 14:00
Lunch

13
13:30 Excursion / Free time
14:00 Check-in /14 Registration /Poster Hanging

14:00 - 14:30

Rosemary Akhurst
14:30 - 17:00

Session 2

TGF-β signaling and cancer
Chair: Xiao-Fan Wang

15

14:30 - 15:30

Xiao-Fan Wang
Kunxin Luo
15:30 - Poster Viewing /16:00 Coffee Break16

17

16:00 - 17:00

Takeshi Imamura
Xiao-Jing Wang
17:00 - 18:00
Poster Session A

17:00 - 18:00
Poster Session B

19:00 - 21:00
Banquet at Grandview(16th Floor)

19:00 - 21:00
Dinner18

19:00 - 21:00
Poster Viewing /19 Welcome Reception
in Foyer (2nd floor)

20812:00 - 12:15
Closing Remarks

The 59 th

Fujihara International Seminar

ProgramWednesday, July 14
14:00 - 21:00

Check-in / Registration / Poster Hanging

19:00 - 21:00

Poster Viewing / Welcome Reception in Foyer (2nd floor)

Thursday, July 15
9:00 - 9:30

Opening Remarks
Introductory Video Presentation of Fujihara Seminar
Greeting
Soji Ban (The Fujihara Foundation of Science)
Introductory Remarks
Kohei Miyazono (University of Tokyo)

Session 1. Molecular mechanisms of TGF-β family signaling
Chair: Carl-Henrik Heldin (Uppsala University)
9:30 - 10:00
10:00 - 10:30
10:30 - 11:00
11:00 - 11:30
11:30 - 12:00

12:00 - 12:30
12:30 - 14:00
14:00 - 14:30

Carl-Henrik Heldin (Uppsala University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .14
Non-Smad signaling downstream of TGF-β receptors
Mitsuyasu Kato (University of Tsukuba) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .16
Smad traps for negative regulation of TGF-β signaling
Poster Viewing / Coffee Break
Aristidis Moustakas (Uppsala University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .18
Negative regulation of TGFβ and Smad signaling
Keiji Miyazawa (Yamanashi University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .20
An Id-like molecule, Maid, is a cellular-response selective regulator ofTGF-β signaling
Xin-Hua Feng (Baylor College of Medicine) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .22
Coupled Actions of PPM1A and RanBP3 Terminate SMAD Nuclear Functions
Lunch
Rosemary Akhurst (UCSF) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .24
Genes that regulate the phenotypic outcome of altered TGF-β signalingin vivo: A mouse-to-human genetics approach

Session 2. TGF-β signaling and cancer
Chair: Xiao-Fan Wang (Duke University)14:30 - 15:00

15:00 - 15:30
15:30 - 16:00
16:00 - 16:30

16:30 - 17:00

Xiao-Fan Wang (Duke University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .26
TGF-β promotes hepatocellular carcinoma intrahepatic metastasis byenhancing Treg cell recruitment via miR-34a-CCL22 pathway
Kunxin Luo (UC Berkeley) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .28
Expression and function of SnoN in normal mammary gland development
Poster Viewing / Coffee BreakTakeshi Imamura (Cancer Institute of JFCR) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .30
Nuclear Receptors Inhibit TGF-β Signaling Pathway via Smad Degradation:
Implication for Cancer Progression
Xiao-Jing Wang (University of Colorado Denver) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .32
Distinct roles of Smads in squamous cell carcinomas

17:00 - 18:00

Poster Session A

19:00 - 21:00

Banquet at Grandview (16th Floor)

10The 59 thFujihara International Seminar

Friday, July 16
7:30 - 8:30

Business meeting of JSPS Core-to-Core Program

Session 3. TGF-β signaling and vascular, bone, and other diseases
Chair: Rik Derynck (UCSF)
9:00 - 9:30
9:30 - 10:00

10:00 - 10:30

10:30 - 11:00
11:00 - 11:30
11:30 - 12:00

12:00 - 13:30
13:30 17:00 - 18:00
19:00 - 21:00

Rik Derynck (UCSF) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .34
Role of mTOR signaling in TGF-β-induced EMT
Hideyuki Beppu (University of Toyama) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .36
BMPR2-deficiency causes abnormal cell proliferation in cardiovascular andintestinal tracts
Ye-Guang Chen (Tsinghua University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .38
Genome-wide Analysis of Smad Targets Reveals the Role of BMP Signaling in
Embryonic Stem Cell Fate Determination
Poster Viewing / Coffee BreakAkiko Hata (Tufts Medical Center) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .40
Regulation of Vascular Smooth Muscle Cell Phenotype by TGF-βPeter ten Dijke (Leiden University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .42
TGF-β signaling in tumor cell invasion and angiogenesis
Group Photo / Lunch
Excursion / Free time
Poster Session BDinner

Saturday, July 17
Session 4. Implications in TGF-β-based therapies
Chair: Seong-Jin Kim (Gachon University of Medicine and Science)
9:00 - 9:30

9:30 - 10:00
10:00 - 10:30

10:30 - 11:00
11:00 - 11:30
11:30 - 12:00

Seong-Jin Kim (Gachon University of Medicine and Science) . . . . . . . . . . . . . . . . . . . . . . . .44
Association of TRAF6 and the type III TGF-β receptor bridges IL-1β-mediatedrepression of TGF-β signaling
S. Paul Oh (University of Florida) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .46
Roles of TGF-β receptors in vascular development and diseases
Makoto Mark Taketo (Kyoto University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .48
Inactivation of TGF-β signaling and colon cancer liver metastasis:Role of CCR1+ immature myeloid cells
Poster Viewing / Coffee BreakAtsushi Hirao (Kanazawa University) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .50
Roles of TGF-β/FoxO in the maintenance of leukemia stem cells
HQ Han (Amgen) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .52
Pharmacological Blockade of Myostatin and Activin Leads to Reversal ofCancer Cachexia and Prolongation of Lifespan in Tumor-Bearing Animals

12:00 - 12:15

Closing Remarks
Susumu Nishimura (The Fujihara Foundation of Science)
Kohei Miyazono (University of Tokyo)

12:30 -Lunch / Departure

11

The 59 th

Fujihara International Seminar

Poster Session A (Thursday, July 15)
A01

Eunjin Bae (Gachon University of Medicine and Science)..............................................................................58
Traf6 is a key mediator of TGF-β induced metastasis

A02

Kana Horiguchi (University of Tokyo) .......................................................................................................58
Molecular mechanism of Snail induction by TGF-βA03

Yukari Hoshino (University of Tokyo) .......................................................................................................59
Autocrine TGF-β protects breast cancer cells from apoptosis through reduction ofBH3-only protein, Bim

A04

Ja-shil Hyun (Gachon University of Medicine and Science) ...........................................................................59
Smad7 enhances the proteasomal degradation of c-Myc protein by binding FBW7

A05

Kimihito C. Kawabata (University of Tokyo) ............................................................................................60
TGF-β downregulates CD20 and inhibits growth of B lymphoma cells.

A06

Young-Woong Kim (Gachon University of Medicine and Science) ...............................................................60
N-linked glycosylation is essential for the stability and cell surface localization oftype II TGF-β receptor

A07

Hyun-Joo Lee (Gachon University of Medicine and Science) .........................................................................61
Divergent Roles of Smad2 and Smad3 in the Regulation of Arthritogenic
T Helper 17 Cells

A08

Hajime Mihira (University of Tokyo) .........................................................................................................61
TGF-β2 induces endothelial-mesenchymal transition of MS-1 endothelial cells

A09

Koji Miyabayashi (University of Tokyo) ....................................................................................................62
Preclinical Molecular Targeting Therapy of Pancreatic Cancer using
a Genetically Engineered Mouse Model

A10Naoko Nakano (University of Tsukuba) ....................................................................................................62
TCF7L2 coordinates with Smads to regulate TGF-β-mediated transcription ofTMEPAI gene

A11

Yo-taro Shirai (University of Tokyo) .........................................................................................................63
BMP plays a tumor suppressive role in diffuse-type gastric carcinoma development

A12

Kyung-Min Yang (Gachon University of Medicine and Science) ...................................................................63
DRAK2 binds to the TGF-β receptors to suppress TGF-β signaling pathway.

A13

Jeong-Hwan Yoon (Gachon University of Medicine and Science) ................................................................64
TGF-β signaling through Smad3 and Smad4 targets Eomesodermin to suppress
CD8+ cytotoxic T cells in DNFB-induced contact hypersensitivity

A14

Kwiyeom Yoon (Gachon University of Medicine and Science) ......................................................................64
Expression analysis of TGF-β signaling-related genes and identification of novel SNPs
by total RNA sequencing in human gastric cancer cell lines

56

The 59 thFujihara International Seminar

Poster Session B (Friday, July 16)
B01

Shogo Ehata (University of Tokyo) ...........................................................................................................66
TGF-β diminishes the SP fraction of the diffuse-type gastric carcinoma cells

B02

Hideaki Ijichi (University of Tokyo) ...........................................................................................................66
Blockade of CXC Chemokines/CXCR2 Axis Inhibits Pancreatic Ductal Adenocarcinoma
Progression through Anti-angiogenesis

B03

Yasumichi Inoue (The Japanese Foundation for Cancer Research) ................................................................67
Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent breast cancer
metastasis to bone

B04

Fumiko Itoh (University of Tsukuba) .........................................................................................................67
Vascular endothelial cell-specific Smad2 and Smad3 signaling is required forblood vessel integrity

B05

Kaoru Kahata (Uppsala University)...........................................................................................................68
An HMGA2-regulated gene signature provides a novel molecular mechanism
underlying regulation of stemness in breast cancer

B06

Yuto Kamiya (University of Tokyo) ..........................................................................................................68
Smad7 inhibits transforming growth factor-β family type I receptors throughtwo distinct modes of interaction

B07

Mitsunobu R. Kano (University of Tokyo) ................................................................................................69
Treating “intractable” tumours by nanoDDS and TGF-β inhibitor

B08

Yoko Katsuno (University of Tokyo) .........................................................................................................69
Cancer-initiating cell population in diffuse-type gastric carcinoma cells has
high ALDH1 activity

B09

Daizo Koinuma (University of Tokyo) .......................................................................................................70
Characterization of Smad2 and Smad3 binding sites by genome-wide
ChIP-chip/ChIP-sequencing analysis

B10

Masako Oka (University of Colorado Denver) .............................................................................................70
HGF Upregulation Contributes to Angiogenesis in Mice with
Keratinocyte-Specific Smad2 Deletion

B11

Seok Hee Park (Sungkyunkawn University) ...............................................................................................71
TGF-β1-induced MyD88 degradation is driven by Smad6-Smurf pathway,but not Smad7

B12Hiroshi I. Suzuki (University of Tokyo) ......................................................................................................71
Regulation of autophagy by transforming growth factor-β (TGF-β) signaling

B13

Eleftheria Vasilaki (Uppsala University)....................................................................................................72
Transcriptional regulation of the small GTPase RhoB gene by TGFβ-induced signaling
pathways

B14

Tetsuro Watabe (University of Tokyo) ......................................................................................................72
BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

57