PROGRAM BOOK
1st International Societies for
Investigative Dermatology Meeting
10-13 May 2023
Tokyo, Japanwww.isid2023.org

Thank you ISID 2023 sponsors.
PLATINUMGOLDSILVER

Greetings from President of ISID––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Russell Hall, MD

On behalf of the International Societies for
Investigative Dermatology (ISID) and all of
our member societies I want to welcome
you to the first international meeting of the
ISID. In 2018, the ESDR, JSID and SID held
the 7th and last International Investigative
Dermatology (IID) meeting in Orlando,
Florida. The first IID meetings was in
Washington, DC in 1989 in response to
the growing global reach of investigative
dermatology and cutaneous biology.
Subsequently every 5 years the ESDR, JSID
and SID have hosted scientific meeting,with rotating locations between the UnitedStates, Europe and Japan.
Over the ensuing 35 years it became
increasingly
clear
that
international
investigative dermatology had grown to
involve more than just the ESDR, JSID and
SID. It was felt that a structure was needed
to support investigative dermatology aroundthe world and to conduct, encourage andfacilitate collaboration between all scientists
focused on investigative dermatology andcutaneous biology. A critical part of thatmission was a commitment to hold an
abstract driven, peer reviewed scientificmeeting every 5 years hosted on a rotatingbasis by investigative dermatology societies
from Asia and Australasia, from Europe,

Middle East and Africa and from North,Central and South America. In 2015 the ISID
was established by the charter societiesof the ESDR, JSID and SID. Over the last 8
years ISID has grown to include member
societies from Korea, Chinese Taipei and ourassociate member, the Australasian Societyof Dermatology Research.
This year the JSID and our societies from theAsia region are hosting our first International
Societies for Investigative Dermatology
meeting in Tokyo. We are all especially eager
to gather together as a worldwide communityof scientist after the years of isolation that
COVID has required. This meeting will bring
together investigators, residents and fellows
from around the world, all focused on
advancing the science of dermatology andcutaneous biology. The program includes
presentation of the latest in cutting edge
research focused on cutaneous biology anddermatology from our colleagues around theworld. Special lectures from experts within
and outside of our communities will occur
every day. In addition, numerous high quality
symposia reviewing the latest advances incutaneous biology and skin diseases will
occur throughout the meeting. Perhaps
most importantly we will once again havethe opportunity to meet in person, discuss

our science, learn together and enjoy the
personal collegiality that is the hallmark of
our international community. Our venue inTokyo is exceptional and numerous social
events have been planned to celebrate thecollaboration and collegiality of scientists
around the world that has marked past IID
meetings.
The ISID and all of our members fromaround the world welcome you to ISID
2023. It is our hope and expectation that bygathering together, enjoying the high qualityof science, reconnecting with colleagues
and meeting new friends and collaborators
you will be energized and refreshed.
Welcome to ISID 2023.

Greetings from President of ISID 2023––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Kenji Kabashima, MD/PhD
The International Societies for Investigative
Dermatology (ISID) was established in 2013
with the aim of internationally integratingorganizations dedicated to the study of skinbiology in the world. The predecessor to thecurrent SID/JSID joint congress was heldin Washington DC, USA in 1985, and it later
evolved into the International Investigative
Dermatology (IID). IID has been held every 5
years: recently Miami (USA) in 2003, Kyoto(Japan) in 2008, Edinburgh (UK) in 2013 andOrlando (USA) in 2018, and IID has mademajor contributions to the development ofskin biology.
Until now, only JSID from Asia has joinedand developed IID. However, this time, it
took a new step as ISID to become a true
international society by joining similarsocieties all over the world including KSID,
TSID and ASDR.
The skin is the largest organ in the humanbody and plays a central role in homeostasis

and biological defense as a unique sitewhere the external world and the organism
come into contact. In fact, the Nobel Prizein Physiology or Medicine for 2021 wasawarded to the study of sensory sensors
in the skin. At this conference, cuttingedge and advanced skin research will bepresented and exchanged by researchers
around the world. The results from crosssectoral fields such as molecular biology,
developmental and regenerative medicine,immunology and allergy, biochemistry, andartificial intelligence will be reported on
the skin, and it is expected that the results
will contribute to clinical medicine such as
the conquest of diseases and improve thewelfare of the nation.
The program will feature keynote lectures
by world-leading researchers, including
Professor Shinya Yamanaka of the Institutefor iPS Research at Kyoto University, aseries of plenary and thematic concurrent
symposia, and a number of submissions

by the researchers from all over the world
through the four-day meeting In addition, byorganizing the Future Leaders Symposium,
we will support to promote the participationand presentation of young researchers.
ISID 2023 will be the first international
conference since the establishment of
ISID. We will strive for success not only
academically but also from the perspectiveof human resource development for our
future. We deeply hope that skin researchers
will come to Tokyo from all over the worldand enjoy skin biology and science.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

3

Dear ISID 2023 delegates,
On behalf of the 14 million citizens of Tokyo, I would like to express our warm welcome to theFirst International Societies for Investigative Dermatology Meeting in Tokyo.
With a history of over 400 years, Tokyo is a city of distinct character and tradition - not just a politicaland economic center but also a wellspring of culture.
Tokyo is a city that meets the needs of any guest visiting to attend a meeting. It boasts a state-of-theart telecommunications network and a sophisticated public transport system, which runs on precise
timetables from early morning to late at night. When faced with the unprecedented challenges of a
global pandemic, Tokyo quickly adapted to hybrid meetings, utilizing the latest technology. While
numerous hybrid conferences have been held in Tokyo, the city is already welcoming back many inperson participants from overseas, ensuring safety with stringent hygiene measures.
Tokyo is a fascinating destination with an eclectic mix of tradition and innovation. The traditional
culture from the Edo period in the 17th to 19th centuries and cutting-edge technology stand side byside. From the most popular tourist spots like the iconic Shibuya crossing to the Tama area’s richnature and the islands of Tokyo, a wide variety of options awaits the visitors. We are confident thatthe conference attendees will enjoy the many attractions Tokyo has to offer, including the arts,
shopping, and exquisite Japanese and global cuisine.
Please accept my best wishes for a successful meeting and an enjoyable stay in Tokyo filled withlasting memories.

Yuriko Koike
Governor of Tokyo

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1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Meeting At-A-Glance
WEDNESDAY,
MAY 10, 2023_____________________________________________________
07:30 – 19:00

On-Site Registration

Room: Hana_____________________________________________________
12:00 – 14:30

Future Leaders Symposium

Room A: Concord Ballroom_____________________________________________________
14:30 – 15:00

LEO Foundation Awards

Room A: Concord Ballroom_____________________________________________________
15:10 – 15:40

Opening Ceremony

Room A: Concord Ballroom_____________________________________________________
15:40 – 16:40

Rising Star Lectures

Room A: Concord Ballroom_______________________________________________________________________________________________________________________________________________________________

09:45 – 10:15

15:55 – 16:25

Room A: Concord Ballroom_____________________________________________________

Room A: Concord Ballroom_____________________________________________________

JSID Special Guest Lecture:
Recent Progress in iPS Cell Research andApplication
10:20 – 11:20

Sanofi Symposium

11:20 – 11:50

18:10 – 19:40

Room A: Concord Ballroom_____________________________________________________

Poster Session 1– ODD FINAL ID/Poster #’s

12:05 – 13:05

UCB Symposium

ePoster Discussions, Session 1: Adaptive
Immunity 1 & 2

12:05 – 13:05

18:10 – 19:40

Room A: Concord Ballroom_____________________________________________________

Room A: Concord Ballroom_____________________________________________________

Room A: Concord Ballroom_____________________________________________________

12:05 – 13:05

Room B: Eminence Hall_____________________________________________________

16:50 – 18:20

Bristol Myers Squibb Symposium

Room B: Eminence Hall_____________________________________________________

12:05 – 13:05

18:20 – 20:20

Welcome Reception

Room B: Eminence Hall, Room C: Nishiki,
Room D: Ohgi, and Lobby_____________________________________________________THURSDAY,MAY 11, 2023_____________________________________________________
06:30 – 19:30

Room C: Nishiki_____________________________________________________

Pfizer Symposium

Room D: Ohgi_____________________________________________________
12:05 – 13:05

Amorepacific Symposium

Room E: Moonlight_____________________________________________________
12:05 – 13:05

CHANEL Fragrance & Beauty Symposium

Room F: Harmony_____________________________________________________

Room: Hana_____________________________________________________
07:00 – 08:00

Room A: Concord Ballroom_____________________________________________________
07:00 – 08:00

Otsuka Pharmaceutical Symposium

Room B: Eminence Hall_____________________________________________________
07:00 – 08:00

Kaken Pharmaceutical Symposium

Room C: Nishiki_____________________________________________________

Room A: Concord Ballroom_____________________________________________________

08:10 – 09:10

18:10 – 19:40

ePoster Discussions, Session 1:
Carcinogenesis and Cancer Genetics/
Photobiology/Skin of ColorNS Building, ePoster Stage #4_____________________________________________________
18:10 – 19:40

NS Building, ePoster Stage #5_____________________________________________________

Social Gathering

Room A: Concord Ballroom & Room B:
Eminence Hall_____________________________________________________

06:30 – 19:30

Room: Hana_____________________________________________________

Room C: Nishiki_____________________________________________________

Concurrent Mini-Symposium 4: ClinicalResearch – Epidemiology and Observational
Research I

Room D: Ohgi_____________________________________________________

09:15 – 09:45

Room E: Moonlight_____________________________________________________

Concurrent Mini-Symposium 5: Genetic
Disease, Gene Regulation, and Gene Therapy
13:15 – 15:45

Room A: Concord Ballroom_____________________________________________________NS Building, ePoster Stage #3_____________________________________________________

13:15 – 15:45

13:15 – 15:45

SID William Montagna Lecture:
Neuroimmune Mechanisms Underlying
Atopic Dermatitis Itch and Inflammation

ePoster Discussions, Session 1: Tissue
Regeneration and Wound Healing/SkinAppendages, & Stem Cell Biology

Room B: Eminence Hall_____________________________________________________Plenary Session 1

Room A: Concord Ballroom_____________________________________________________

18:10 – 19:40

FRIDAY,MAY 12, 2023_____________________________________________________

Concurrent Mini-Symposium 2: Artificial
Intelligence (AI) and Image Analysis/
Translational Studies

13:15 – 15:45

AMRYT Symposium

NS Building, ePoster Stage #2_____________________________________________________

13:15 – 15:45

Room D: Ohgi_____________________________________________________

Room F: Harmony_____________________________________________________

ePoster Discussions, Session 1: ClinicalResearch – Epidemiology and Observational
Research 1 & 2

19:50 – 21:50

13:15 – 15:45

07:00 – 08:00

07:00 – 08:00

NS Building, ePoster Stage #1_____________________________________________________

Room G: Takao_____________________________________________________

Concurrent Mini-Symposium 3:
Carcinogenesis and Cancer Genetics

Taisho Pharmaceutical Symposium

18:10 – 19:40

ePoster Discussions, Session 1: Genetic
Disease, Gene Regulation, and Gene Therapy

Concurrent Mini-Symposium 1: Adaptive
and Auto-Immunity I

Japan Blood Products Organization
Symposium(including ODD Late-Breaking #’s)
NS Building_____________________________________________________

12:05 – 13:05

Galderma Symposium

On-Site Registration

Room B: Eminence Hall_____________________________________________________

Stephen I. Katz MD/PhD Memorial
Lectureship Award: Immune-tissue
Crosstalk during Homeostasis and Disease

16:50 – 18:20

Maruho Symposium

16:30 – 18:00

Plenary Session 2

Taiho Pharmaceutical/Janssen
Pharmaceutical K. K. Symposium

AbbVie Sympsium

ESDR Rudi Cormane Lecture: Deciphering
Pathways in the Syndromic Keratodermas:
Insights into Oesophageal Cancer

Concurrent Mini-Symposium 6: Tissue
Regeneration and Wound Healing

Room F: Harmony_____________________________________________________

On-Site Registration
07:00 – 08:00

ISID Member Organizations General
Assemblies/Business Meetings

JSID – Room B: Eminence Hall
SID – Room C: Nishiki
ESDR – Room D: Ohgi
TSID – Room E: Moonlight_____________________________________________________
07:45 – 08:00

American Skin Awards (ASA) 2023 Research
Achievement Awards Presentation
Room C: Nishiki_____________________________________________________
08:10 – 09:10

Plenary Session 3

Room A: Concord Ballroom_____________________________________________________
09:15 – 09:45

SID Special Guest Lecture: RNA origin of
sex-biased immunity

Room A: Concord Ballroom_____________________________________________________

6

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGMeeting At-A-Glance______________________________________________________________________________________________________________________________________________________________

09:45 – 10:15

18:10 – 19:40

09:15 – 09:45

Room A: Concord Ballroom_____________________________________________________(including EVEN Late-Breaking #’s)
NS Building_____________________________________________________

10:20 – 11:20

18:10 – 19:40

KSID Special Guest Lecture: Adiponectin
and Skin Diseases

Plenary Session 4

Room A: Concord Ballroom_____________________________________________________
11:20 – 11:50

TSID Special Guest Lecture: Precision
Medicine of Common Diseases

Room A: Concord Ballroom_____________________________________________________
12:05 – 13:05

Janssen Asia Pacific Symposium

Room A: Concord Ballroom_____________________________________________________
12:05 – 13:05

Nippon Boehringer Ingelheim Symposium

Room B: Eminence Hall_____________________________________________________
12:05 – 13:05

No 7 Beauty Company Symposium

Room C: Nishiki_____________________________________________________

Poster Session 2 – EVEN FINAL ID/Poster #’sePoster Discussions, Session 2: Artificial
Intelligence (AI) and Image Analysis/
Translational Studies/Pigmentation &Melanoma

NS Building, ePoster Stage #1_____________________________________________________
18:10 – 19:40

ePoster Discussions, Session 2:
Innate Immunity, Microbiology, andMicrobiome I & II

NS Building, ePoster Stage #2_____________________________________________________
18:10 – 19:40

ePoster Discussions, Session 2: Cell-Cell
Interactions in the Skin/Epidermal Structure
and Barrier Function

NS Building, ePoster Stage #3_____________________________________________________
18:10 – 19:40

12:05 – 13:05

ePoster Discussions, Session 2:
Pharmacology and Drug Development/
Clinical Research – Interventional Research/
Clinical Research-Socio-behavioral and
Health Services Research

Room E: Moonlight_____________________________________________________

18:10 – 19:40

12:05 – 13:05

Shiseido Symposium

Room D: Ohgi_____________________________________________________LEO Pharma Symposium
12:05 – 13:05

Torii Pharmaceutical Company, LTD.
Symposium

Room F: Harmony_____________________________________________________
13:15 – 13:45

ESDR Special Guest Lecture: Skin T cells
in Lockdown – Regulation of Human T Cell
Tissue Residency

Room A: Concord Ballroom_____________________________________________________NS Building, ePoster Stage #4_____________________________________________________

ePoster Discussions, Session 2:
Late-Breaking Abstract Submissions

NS Building, ePoster Stage #5_____________________________________________________

Room A: Concord Ballroom_____________________________________________________
15:30 – 18:00

Concurrent Mini-Symposium 7: Adaptive
and Auto-Immunity II

Room B: Eminence Hall_____________________________________________________
15:30 – 18:00

Concurrent Mini-Symposium 8:
Epidemiology and Observational Research II

Room C: Nishiki_____________________________________________________
15:30 – 18:00

Concurrent Mini-Symposium 9: Innate
Immunity, Microbiology, Microbiome I

Room D: Ohgi_____________________________________________________
15:30 – 18:00

Concurrent Mini-Symposium 10:
Pharmacology and Drug Development

Room E: Moonlight_____________________________________________________
15:30 – 18:00

Concurrent Mini-Symposium 11:
Photobiology/Skin of Color

Room F: Harmony_____________________________________________________
15:30 – 18:00

Concurrent Mini-Symposium 12: Skin,
Appendages and Stem Cell Biology

Room G: Takao_____________________________________________________Room
A: Concord Ballroom_____________________________________________________
09:45 – 10:15

ESDR Special Guest Lecture: Skin Myeloid
Cell Heterogeneity

Room
A: Concord Ballroom_____________________________________________________
10:20 – 11:50

Novartis Pharma K.K. Symposium

Room
A: Concord Ballroom_____________________________________________________
12:05 – 13:05

UCB Symposium

Room
A: Concord Ballroom_____________________________________________________
12:05 – 13:05

Janssen Pharmaceutical/Taiho
Pharmaceutical Symposium

Room
B: Eminence Hall_____________________________________________________
12:05 – 13:05

Mitsubishi Tanabe Pharma/Teikoku Saiyaku
Symposium

Room C: Nishiki_____________________________________________________
12:05 – 13:05

The Estée Lauder Companies Inc.
Symposium

Room
D: Ohgi_____________________________________________________
12:05 – 13:05

SUN Pharma Symposium

Room
E: Moonlight_____________________________________________________
12:05 – 13:05

19:50 – 21:50

Procter & Gamble Symposium

CÉ LA VI TOKYO – 18th Floor of Tokyu Plaza Shibuya
Ticketed Event: Pre-registration required.
Space is limited. Please check withregistration desk for availablility.
_____________________________________________________

13:15 – 15:45

Young Investigator Collegiality Event

Room
F: Harmony_____________________________________________________

Concurrent Mini-Symposium 13: Cell-Cell
Interactions in the Skin

Room
A: Concord Ballroom_____________________________________________________
13:15 – 15:45

13:50 – 15:20

Eli Lilly Symposium

SID Special Guest Lecture: The Evolutionof Human Skin Pigmentation as a Long andComplex Biocultural Phenomenon

SATURDAY,MAY 13, 2023_____________________________________________________
06:30 – 19:30

On-Site Registration

Room: Hana_____________________________________________________
07:00 – 08:00

NOV Division, TOKIWA Pharmaceutical Co.,
Ltd. Symposium

Room A: Concord Ballroom_____________________________________________________
07:00 – 08:00

Amgen Symposium

Room B: Eminence Hall_____________________________________________________

Concurrent Mini-Symposium 14: ClinicalResearch – Socio-behavioral and HealthServices Research/Clinical ResearchInterventional Research

Room B: Eminence Hall_____________________________________________________
13:15 – 15:45

Concurrent Mini-Symposium 15: Epidermal
Structure and Barrier Function

Room C: Nishiki_____________________________________________________
13:15 – 15:45

Concurrent Mini-Symposium 16: Innate
Immunity, Microbiology, Microbiome II

Room
D: Ohgi_____________________________________________________
13:15 – 15:45

07:00 – 08:00

Concurrent Mini-Symposium 17:
Pigmentation and Melanoma

Room C: Nishiki_____________________________________________________

13:15 – 15:45

Sato Pharmaceutical/Eisai Co. Symposium

Room E: Moonlight_____________________________________________________

Nobelpharma Symposium

Concurrent Mini-Symposium 18:
Late-Breaking Abstracts

07:00 – 08:00

15:50 – 16:00

Room E: Moonlight_____________________________________________________

Room A: Concord Ballroom_____________________________________________________

07:00 – 08:00

Room D: Ohgi_____________________________________________________

Incyte Symposium

Room F: Harmony_____________________________________________________

Closing Ceremony

08:10 – 09:10

16:05 – 18:05

Room A: Concord Ballroom_____________________________________________________

Room A: Concord Ballroom_____________________________________________________Plenary Session 5

Asia Oceania Symposium

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Meeting Information & Policies––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

COVID-19 VACCINATIONRELATEDIn the Fall of 2022, the Japanese
Government loosened restrictions onentering the country. COVID-19 Related
Visas are no longer needed (with a few
exceptions) for most attendees to enter
into Japan, however it is best to check withyour specific government entity to ensurethat you have a checklist of documentationneeded to attend the ISID 2023 Meetingin Tokyo.
As of March 13, 2023, the Country ofJapan, the City of Tokyo, and the Keio
Plaza Hotel will NOT have a mask policy
in place. As such, it is up to the meeting
attendee whether they choose to wear
a protective mask or not. Masks will bemade available to all meeting attendees.
Although the guidelines are designed toallow individuals to judge for themselves
when to wear a mask in their daily lives,
people will be recommended to wear themin certain situations, such as if they aredisplaying symptoms of the disease orwhenever they visit a medical institution.
For further information, visit Japan’s
Ministry of Foreign Affairs COVID webpageat https://www.mofa.go.jp/p_pd/pds/
page22e_000910.html

REPRODUCTION AND
PHOTOGRAPHY POLICY

Any photography, filming, taping, recording,or reproduction in any medium of any of
the Programs, exhibits, or lectures (oral orposters) presented at the ISID 2023 Meeting
without written permission is strictly
prohibited. Failure to comply with thisrule may lead to removal of your meeting
credentials.
Official ISID Photographers will capture
moving and still images throughout theevent. This may include all public spaces,
meeting rooms and individuals/groups.

ON-SITE REGISTRATION

On-site registration will take place at Room
Hana C & D (on the 4th floor of the main
tower of the Keio Plaza Hotel) during thefollowing hours:• Wednesday, May 10, 2023, 07:30 – 19:00• Thursday, May 11, 2023, 06:30 – 19:30• Friday, May 12, 2023, 06:30 – 19:30• Saturday, May 13, 2023, 06:30 – 12:00

BADGES

Badges for both pre- and on-site registration
can be picked up at the Registration areain Room Hana C & D (4th floor in the main
tower of the Keio Plaza Hotel). Meeting
attendees are required to wear their badges
for entry into all sessions and meeting
activities.

8

SPECIAL SERVICES FOR THE
PHYSICALLY CHALLENGED•

The Keio Plaza Hotel is fully accessible
to the physically challenged. Should you
have any special needs, please stop at theregistration area and notify available staff.

CHILD CARE RELATEDThe ISID 2023 Meeting is only for registeredattendees and who are over the age of 18
years old. Children 17 years old and younger
will be prohibited in ISID Meeting spaces
due to liability issues.

•
•

Wi-Fi

Wireless internet will be made available toall meeting attendees in all the ISID Meeting
spaces. Information on how to log onto thewireless service will be provided with namebadges.

MESSAGE BOARD

There will be a message board foradvertisements as well as reaching out tocolleagues. The message board will belocated adjacent to the registration area.

NURSING MOTHERS

As a part of a family-friendly meeting
experience, the ISID supports breastfeeding
mothers by accommodating the mother
who wishes to express breast milk during
her meeting participation when separated
from her newborn child. Nursing mothers
wishing to use this space should contact
the ISID Staff at the Registration area, whowill provide access to available areas.

CODE OF CONDUCTInternational Societies for Investigative
Dermatology (ISID) welcomes the use ofsocial media during the 2023 Meeting
including live tweeting. The SID and
Journal of Investigative Dermatology(JID) will employ the use of social media
ambassadors throughout the meeting toshare highlights of the content that will bepresented. Communication in this day andage happens swiftly and has the potential
to bring about unforeseen occurrences. To
minimize situations that could be perilous,please note the following 2023 Meetingsocial media guidelines:
Do:• Follow the ISID on Twitter (@ISID2023Tokyo) and use the#ISID2023Tokyo hashtag to join theconversation about the ISID 2023
Meeting.
• Like the ISID on Facebook at https://www.facebook.com/ISID2023Tokyo/• Like the ISID on Instagram at
Isid2023tokyo.

•

Blog or tweet about what you hearand learn at the meeting but refrainfrom sharing any content the speaker/
presenter explicitly asks not to share.
Presenters will be asked to place
the words DO NOT POST on theirpresentations, slides, and pictures thatthey do not wish to share. Do not shareor post specific details or slides (unlessotherwise indicated).
Converse and network with otherattendees before, during, and after the
meeting.
Provide feedback to ISID leadership,
staff, and the ISID Scientific Program
Committee – we encourage attendees topost about and discuss topics of interestand ideas for future scientific meetings.
Communicate with respect andconsideration for others and keep
criticism constructive.

Don’t:• Capture, transmit, or redistributedata presented at the meeting – thismay preclude its later publication ina scientific journal. Please adhere tojournal embargo policies and do notjeopardize your colleagues’ work!
• Post copyrighted or trademarked
material or material protected by otherintellectual property rights.
• Use ISID’s social media platforms tocomment on medical, legal, or litigious
matters.
• Post derogatory, demeaning,inflammatory, offensive, disrespectful,
hateful, sales-oriented, or otherwise
inappropriate comments.
People who participate in social media
activity associated with the ISID Meetingare also expected to:• Maintain a courteous and respectfuldemeanor in their comments and posts.
• Contribute value and expertise.
• Represent themselves and theirorganizations truthfully andprofessionally.
• Recognize that social media
conversations include a variety ofprofessionals, patients, policymakers,
reporters, and the public.
The views and opinions posted on ISID’s
social media do not necessarily reflect theviews, opinions, or policies of the ISID, its
Board, or staff. The ISID reserves the rightto remove comments it deems, in its sole
discretion, to be inappropriate.
Photo Credits:
Nick Kwan: 2624818.jpg
Alex Knight: 2599247.jpg
All printed program content is current
as of April 20, 2023.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGAbstract Presentation Information––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––ORAL TYPE PRESENTATIONSAll Plenary and Concurrent Minisymposia oralpresentations will take place at the Keio Plaza
Hotel. ePoster Discussions presentations willtake place at the NS Building (located via ashort walk from the Keio Plaza Hotel).
Plenary and Concurrent Mini-Symposium
Plenary oral presentations are scheduled toallow for ten (10) minutes of presentation andtwo (2) minutes for discussion. To coordinate
sessions, the time limit will be strictly adheredto, or you will be asked to terminate yourpresentation by the session moderator(s).
Concurrent oral presentations are scheduled toallow for eight (8) minutes of presentation andtwo (2) minutes for discussion. To coordinate
sessions, the time limit will be strictly adheredto, or you will be asked to terminate yourpresentation by the session moderator(s).
Selected ePoster Discussions Presentations
Each poster presenter will be asked to briefly
describe their work (one slide only) for up to
three (3) minutes, followed by a short group
discussion of up to two (2) minutes in length.
There will be moderators to assist with thetiming. If your abstract has been selected
for the ePoster Discussions, please join theassigned category group at the relevant
ePoster terminal. Please reference the dailyschedule for dates, times, category, locations,featured posters, and moderators. There willsoon be information provided on how best to
provide your image in advance of your talk.
All Oral Presentations are also to bepresented as Electronic Posters. See schedule
below. All presentations must be uploaded
by Friday, May 5, 2023. Details regarding theUpload procedure have been provided to you
via email and listed on the ISID website. Onsite technical support will also be available.

CONFLICT OF INTEREST

All oral presentations must include a
disclosure slide at the beginning of yourpresentation. If there is a real or perceived
conflict of interest pertaining to your work, anannouncement must be made prior to your oralpresentation and displayed on your poster.

SPEAKER READY ROOM

The speaker ready room will be located in
Room Kaede, located on the 4th floor of themain tower of Keio Plaza Hotel.
The room will be available to all presenters
during the following hours:• Wednesday, May 10, 2023, 07:30 – 17:00• Thursday, May 11, 2023, 06:30 – 17:00• Friday, May 12, 2023, 06:30 – 18:00• Saturday, May 13, 2023, 06:30 – 19:00
All presentations are to be checked in at the
Speaker Ready Room (Kaede) at least 30
minutes in advance of your presentation.

PHYSICAL POSTERPRESENTATIONS• Physical posters will be displayed at
the NS Building (a short walk from themeeting venue). Posters will be viewed
in two (2) sessions as outlined below.
Presenters should be at their posters
for their entire discussion session
and should not be removed early. The
organizers of the ISID 2023 Meetingare not responsible for posters left
unclaimed as of 20:00 on Friday, May
12, 2023. Unclaimed posters will not be
returned.
• Physical poster size is to be 90 cm wideby 160 cm tall (36 inches x 63 inches).
• Please consider adding a QR code to yourposter. The QR code can be used toprovide immediate direction to a lab
website or specific content such as
figures or videos.

Poster Installation:• ODD Poster #’s (for Session 1) can beinstalled on Wednesday, May 10, 2023,
from 14:00 – 16:00 or on Thursday, May
11, 2023, from 10:00 – 12:00, at the NS
Building.
• EVEN Poster #’s (For Session 2) can beinstalled on Friday, May 12, 2023, from10:00 – 12:00, at the NS Building.
Poster Session 1
Thursday, May 11, 2023, 18:10 – 19:40• ODD Final ID/Poster #’s• Late-Breaking ODD Final ID/Poster #’s• DISMANTLE ALL ODD POSTERS byThursday, May 11 at 20:00
Poster Session 2
Friday, May 12, 2023, 18:10 – 19:40• EVEN Final ID/Poster #’s• Late-Breaking EVEN Final ID/Poster #’s
Saturday, May 13, 2023
• DISMANTLE ALL EVEN Posters by
Saturday, May 13, 2023 at 12:00

ePOSTER DISCUSSIONSPRESENTATIONS SCHEDULE
ePoster Session 1
Thursday, May 11, 2023, 18:10 – 19:40• Adaptive and Auto-Immunity I & II:
ePoster Stage # 1/NS Building• Clinical Research – Epidemiology andObservational Research I & II:
ePoster Stage # 2/NS Building• Tissue Regeneration and Wound
Healing/Skin, Appendages, and Stem
Cell Biology:
ePoster Stage # 3/NS Building• Carcinogenesis and Cancer Genetics/
Photobiology/Skin of Color:ePoster Stage # 4/NS Building• Genetic Disease, Gene Regulation, andGene Therapy:ePoster Stage # 5/NS Building
ePoster Session 2
Friday, May 12, 2023, 18:10 – 19:40• Artificial Intelligence (AI) Image
Analysis and Translational Studies/
Pigmentation and Melanoma:ePoster Stage # 1/NS Building• Innate Immunity, Microbiology, andMicrobiome I & II:
ePoster Stage # 2/NS Building• Cell-Cell Interactions in the Skin/
Epidermal Structure and Barrier
Function:ePoster Stage # 3/NS Building• Pharmacology and Drug Development/
Clinical Research, Interventional
Research, and Socio-Behavioral and
Health Services Research:ePoster Stage # 4/NS Building• Late-Breaking Abstracts:
ePoster Stage # 5/NS Building
Electronic Posters:• All abstracts submitted and accepted to
the ISID 2023 are REQUIRED to submit
and upload an image of your poster to all
meetings attendees to access.
• Information on how and where to upload
your poster image can be found at thefollowing web address: https://isid2023.
org/abstract/posters-preparation/• Only those selected for Poster
Presentation ONLY will be required tobring a physical copy of a poster todisplay during one of the two Poster
Sessions noted on this page.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

9

ACCESS MAP
Area Map0
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KDDI Bldg.

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to Shibuya

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KEIO PLAZA
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will find Entrance of
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Shinjuku
NS Bldg.

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College Hospital

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Tokyo Hilton Hotelhi Lin

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Shinjuku
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Hyatt
DaiichiRegency Seimei
Tokyo
Bldg.

Nishi
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Govenrment Office

Green Tower Bldg.

NS Building

Odakyu Dept. Store

Shinjuku-Nishiguchi

Shinjuku Station

1F

JR Lineto Ikebukuro

Lumine ESTSky
Elevatore

Fukutoshin Lin

Maru

Exit from the entrance besidefront desk of Keio Plaza (3F) .
Cross the road in front of theentrance and turn left.

Tochōmae•

Shinjuku Central Park

Park Tower Bldg.

T oe i Ō edo

Direction from Keio Plaza Hotelto NS Building

Lin e––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Kabukicho
area

Multipurpose
toiletRestroom

ALTA Bldg.

Main
EntranceTo
B1F

NS Building

Restroom––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––NS Building
B1F

1F
Sky
Elevator

Multipurpose
toiletMiddle Hall

Restroom

Small Hall

Main
Entrance

Restroom
Poster Printing
Service Pickup

Lobby

To
B1F

Main Hall
Restroom

5

B1F

Middle Hall

10
Lobby

Small Hall

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING
RestroomEast Entrance

Escalator

Lobby
Gallery

Lobby Lounge

Escalator

EV

Keio Plaza Hotel
Meeting Venne Maps

Cocktail＆
Tea Lounge

Rest
room

EV

South
Tower

Main
Tower
EV

Front Desk––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Keio Plaza HotelWest Entrance

3F

４F

Main Tower

South Tower

East Entrance
Natsume Katsura Mizuki

Escalator

EV

Cloak
room

EV

Rest
room

South
Tower

Main
Tower

Cloak
room

Hana

Rest room

Front Desk

HeadquartersEV
KeyakiConnecting
Passage

Escalator

Escalator

EV

EV
Cocktail＆
Tea Lounge

Rest
room

Escalator

Escalator

Lobby
Gallery

Lobby Lounge

Registration/
Bag Distribution/
Exhibition

Room CEV

Nishiki

Kaede

Room DOhgi

PC Preview RoomWest Entrance

４F

To NS Building

Main Tower

Keio Plaza Hotel

Natsume Katsura Mizuki

Registration/
Bag Distribution/
Exhibition

Cloak
room

Escalator

5F

Cloak
room

Hana

EV

Rest
Dahliaroom
NishikiEscalator

Keyaki

Kaede
Cloak
room

PC Preview Room

Restroom

Escalator

EV

Room G
Takao

EV

EV
EV

Room D

Room H

Ohgi

Fuji
Connecting Passage

EV

2
Cattleya

Restroom

Room CEV

HeadquartersConcord Ballroom

Escalator

42F

Connecting
Passage

Escalator

Escalator

Room AEV

Keio Plaza Hotel

Rest
South Tower
room

Main Tower

Rest room

2

South Tower

CosmosRest
room
AzaleaRoom B

43F

Eminence Hall
RestroomEV

Room E
Moonlight

44F

Restroom

Room F
Harmony

3

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

EV

4

11

Meeting Travel Grant Awardees––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Asia/Oceania Region
Travel Grant Awardees:

Australasian Society for
Dermatology Research(ASDR) Recipients:
Holly Anderton
Brigid Betz-Stablein
Christopher Chew
Ghazaleh Hashemi
Abbas Shafiee
Seen Ling Sim
Samuel Tan
Joachim Torrano
Ho Yi Wong
Chenhao Zhou

Japanese Society for
Investigative Dermatology(JSID) Recipients:
Wilson Jr Aala
Akriti Agrawal
Syahla Amalia
Holly Anderton
Anand Kumar Andiappan
Tuba Musarrat Ansary
Terese Monette Aquino
Ryota Asahina
Jai Hee Bae
Avinanda Banerjee
Krishanu Baruah
Brigid Betz-Stablein
Priya Bishnoi
Suphagan Boonpethkaew
Asolina Braun
Sofia Brito
Bao Bui
Jiangluyi Cai
Shu Hao Chang
Hua-Ching Chang
Yen-Tzu Chang
Sasin Charoensuksira
Yang-Yi Chen
Chun-Bing Chen
Xi-bei Chen
Jianru Chen
An-Yu Cheng
Hui-Ching Cheng
Christopher Chew
Yung-Tsu Cho
Seo-Young Choi
Hyun Seung Choi
Eun Ji Choi
Yongsu Choi
So-Jung Choi
Chih-Chang Chou
Carlos Clavel
John Common
Charlotte Cox
Lian Cui
Itaru Dekio
Aoi Ebata
Ummu Faisal
Kenneth Fong
Yangxue Fu
Ryo Fukaura
Yumei Gao
Gracia Goh
Saya Goto
Yimeng Guan
Chunyuan Guo
Yeye Guo

12

Weinan Guo
Sen Guo
Ghazaleh Hashemi
Akitaka Hata
Liting He
Congcong He
Teruyoshi Hisamoto
Yi-Kai Hong
Md Razib Hossain
Wen HuKun HuYingjian Huang
Hsin-Yu Huang
Trang Huynh
Usma Iftikhar
Tetsuya Ikawa
Shinya Imamura
Yuta Inoue
Mami Ishibashi
Yoshihiro Ishida
Tomoka Ito
Young Su Jang
Dilki Jayasinghe
Joslin Johal
Hisashi Kanemaru
Hyun Kang
Pan Kang
Kosuke Katsuo
Akinori Kawakami
Takuya Kawamura
Yoon-Seob Kim
Han Seul Kim
Yul Hee Kim
Su Min Kim
Haruna Kimura
Manao Kinoshita
Mei-Ju Ko
Toshiaki Kogame
Li Fang Koh
Yuta Koike
Risa Konishi
Ken Kosaka
Snehlata Kumari
Miki Kume
Kazuo Kurihara
Haruka Kuriyama
A Yeong Lee
Eun Jung Lee
Chih-Chun Lee
Ji Won Lee
Hanjae Lee
Sze Han Lee
Dongyun Lei
Chen Huei Leo
Jian Li
Zheng-Yi Li
Dongqing Li
Junqin Liang
Sanjay Lietzau
Sung Ha Lim
Youngkyoung Lim
En-Cheng Lin
Yu-Chen Lin
Cheng-Yu Lin
Chien Lin
Yihe Liu
Yiman Liu
Xiaochun Liu
Youxi Liu
Shihuan Valencia Long
Chun-Hao Lu
Lai-Ying Lu
Ying-Yi Lu
Chao Luan
Jingjing Ma
Sheng-Hsiang Ma
Misato Maeno
Shoko Mai
Yosuke Mai
Xiao-Yong Man

Ayaki Matsumoto
Fuuka Minami
Matilde Miranda
Toshiya Miyake
Kodai Miyamoto
Amelia Yuting Monteiro
Kei Nagatani
Satoshi Nakamizo
Maho Nakashima
Bolor Nasanbat
Le Thanh Hai Nguyen
Yuka Nishihara
Yuta Norimatsu
Mariko Ogawa-Momohara
Kentaro Ohko
Ken Okamura
Miyuki Omori-Miyake
Ruo Yan Ong
Felicia Ong
Poyang Pan
Nikolaos Pantelireis
Jui-Hui Peng
Ge Peng
Quoc Thao Trang Pham
Rachel Phua
Sushmita Pradhan
Kim Robinson
Aahan Sachdev
Jun-Ichi Sakabe
Takashi Sakai
Hozumi Sano
Minori Sasakura
Akiyoshi Senda
Seol Hwa Seong
Abbas Shafiee
Yi-Shuan Sheen
Yi-Hsien Shih
Joonho Shim
Yanhong Shou
Huidi Shucheng
Seen Ling Sim
Pu Song
Min Ji Song
Cassandra Styke
Chia-Jui Su
Gowtham Subramanian
Kaito Suemori
Takato Sugiyama
Anggit Sunarwidhi
Wen Yi Sung
Mao Suzuki
Reiko Takayanagi
Tomoya Takegami
Shingo Takei
Hiroaki Takishima
Samuel Tan
Minjia Tan
Yeh Fong Tan
Christina Yan Ru Tan
Tomoyo Taniguchi
Rong Tao
Duerna Tie
Tracy Tien
Shown Tokoro
Manami Toriyama
Joachim Torrano
Hideaki Uchida
Yoichiro Urata
Miki Wada
Mana Wakatake
Ping Wang
Peng Wang
Yu Wang
Ao Wang
Madeline Wang
Chuang-Wei Wang
Xiaojie Wang
Wei-Ning Wang
Ruojun Wang
Huina Wang

Yinghan Wang
Gaofeng Wang
Han-Tang Wang
Yuko Watanabe
Stephen Wearne
JingYu Wei
Ziyu Wei
Ho Yi Wong
Lai-San Wong
Colin Wong
Wei WuNaming Wu
Lei Xiao
Yao XuRui XuXiaotong Xue
Shota Yamaji
Yuriko Yamazaki
Jiang Yang
Luan Yang
Xinyu Yang
Yuqi Yang
Li-Ran Ye
Xiuli Yi
Kazunori Yokoi
Satoru Yonekura
Zengyan Yu
Hainan Yue
Kai Zhang
Yunyue Zhen
PeiMei Zhou
Chenhao Zhou
Yuan Zhou
Guannan Zhu
Ronghui Zhu
Catherine Zilberg

Korean Society for Investigative
Dermatology (KSID) Recipients:
Eun Ji Choi
Hyun Seung Choi
Myoung Eun Choi
Kyung Bae Chung
Young Su Jang
Hyun Kang
Han Seul Kim
Hee Joo Kim
Hong Euy Kim
Su Min Kim
Tae-Gyun Kim
Yoon-Seob Kim
Yul Hee Kim
A Yeong Lee
Eun Jung Lee
Ji Won Lee
Yujin Lee
Youngkyoung Lim
Joonho Shim
Min Ji Song

Taiwan Society for Investigative
Dermatology (TSID) Recipients:
Yeh Fong Tan
Feng-Jen Lin
Po-Wei Huang
Hua-Ching Chang
Sheng-Hsiang Ma
Chia-Bao Chu
Hui-Ching Cheng
Yi-Kai Hong
Zi-Han Jiang

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGMeeting Travel Grant Awardees––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
America’s Region
Travel Grant Awardees:

Europe-Middle East-Africa
Region Travel Grant Awardees:
Abubkr Ahmed
Natalia Alkon
Karl Annusver
Bertram AschenbrennerSari AssafFrancesco Bellinato
Ketaki Bhate
Stephanie Bollard
Szabolcs Bozsányi
Dale Bryant
Anthony Buzzai
Laura Calabrese
Chris Callewaert
Elisa Carrasco
Yun-Tsan Chang
Inchul Cho
Julia Clabbers
Ioana Cosgarea
Giovanni Damiani
Saptaswa Dey
Florentia Dimitriou
Miroslav Dinic
Shirin Emtenani
Sonja Fassbender
Emilie Faway
Kinga Fedor-Lénárt
Clarisse GanierMarta Garcia Diez
Susan Gellert
Ameneh Ghaffarinia
Elena Giusto
William Hariton
Frederick Hartung
Nicola Hermann
Elena Hoffer
Dorottya Horváth
Anhua Hu
Amaani Hussain
Joanna Jackow
Shahnawaz Jadeja
Eleri Jones
Nadine Kamenjarin
Jennifer Keller
Lajos Kemény
Thomas Kirk
Bastian Kruse
Longlong Luo
Su Lwin
Kiril Malovitski
Caroline Mann
Giada Mantellato
Tiago Matos
Johannes Mayer

Katharina Meier
Joost Meijer
Francesco Messina
Deborah Minzaghi
Yasutaka Mitamura
Guillaume Mondon
Veronika Mraz
Ali Nasrallah
Attila Oláh
Elisabetta Palazzo
Kevin Pan
Piotr Parzymies
Michael Peake
Manuela Pigors
Alexandra Polakova
Satyamaanasa Polubothu
Talveen Purba
Marika Quadri
Ravi Ramessur
Anna Redl
Katharina Rindler
Katharina Rolfes
Ann-Helen Rosendahl
Jake Saklatvala
Lídia Sans-De San NicolàsPeter Seiringer
Hannah Serrage
Anya Shyne
Jos Smits
Julie Sølberg
Dimitri Stowbur
Johanna Strobl
Leticia Szadai
Jason Thomson
Matthieu Tihy
Bastien Tirtiaux
Thomas Trafoier
Mairi Treanor-Taylor
Nirohshah Trialonis-SuthakharanZsofia Unger
Kelsey van Straalen
Outi Varpuluoma
Sailan Wang
Xianqing Wang
Sebastian Willenborg
Helen Williams
Dana Wörz
Ahmad Yatim
Reihane Ziadlou
Magdalena Zychowska

Leo Foundation Recipients
Evguenia Alexandrova
Martin AlphonseMichelle Bagood
Corbett Berry
Navaneetha Krishnan Bharathan
Elise Burger
Robert Carlson
Carmelo Carmona-Rivera
Kellen Cavagnero
Felix Chin
Raj Chovatiya
Jin-Sung Chung
Jarish Cohen
Heloise de Baun
Tran Do
Tatsuya Dokoshi
Junyan Duan
Hans I-Chen Harn
Jordan Harris
Yingping HouAustin Johnson
Sam LeeStephen Li
Minglin Liu
Yingzi Liu
Catherine Lu
Sophia Ly
Mitra Maz
Ananya Munjal
Yoshiyuki Nakamura
Teruaki Nakatsuji
Aakriti Neopaney
Allen OakMark Osborn
Jay Patel
Matthew Patrick
Elisabeth Pedersen
Warren Perry
Karol Prieto-Sarmiento
Matthew Ramsey
Adarsh Ravishankar
Allison Remington
Heehwa Son
Qi Tang
Prasanna Vaddi
Enze Xing
Mingang Xu
Shivam Zaver
Yue ZhangDalee Zhou

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Society for Investigative
Dermatology (SID)
Travel Award Recipients:
Khashayar Afshari
Tomoko Akaike
Feras Al Ghazawi
Nathan Archer
Katherine Awh
Lindsey Ayanruoh
Christina Bax
Zhuo Ran Cai
Aheli Chattopadhyay
Guodong Chen
Audris Chiang
Ester Del Duca
Jeremie Delaleu
Edward Eid
Amina El Ayadi
Rony Francois
Emily Gong
Lindsay Gunnell
Renee Haughton
Joy Hsu
Richie JeremianDaniel Joffe
Anusha Kambala
Erica Katz
Charles Kirby
Casey Lee
Daniel Liu
Kathryn Luly
Cassandra Mohr
Vera ObinwanneSyed Minhaj Rahman
Charlotte Read
Ziyou Ren
Vikram Sahni
Aditi Sahu
Mrinal Sarkar
Yevgeniy Semenov
Megan Tran
Sonia Wang
Morgan Ye
Haihan Zhang

AAD/World Congress
Recipients:
Anngela Adams
Negar Foolad
Daniel Kim
Min Jin Lee
Bethany Perez-White
Roberto Ricardo-Gonzalez
Katie Roster
Tadahiko Seo
Yuqing Wang
Kirsten Wong
Christine Yokoyama

13Meeting Travel Grants Supporters––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––The ISID Organizing committee is grateful to the following organizations
for their generous support of travel grants to attend ISID 2023.

14

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGWEDNESDAY

MAY 10, 2023

WEDNESDAY

ISID 2023 Welcome Reception––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023

18:20 – 20:20

ROOM B: EMINENCE HALL, ROOM C: NISHIKI, ROOM D: OHGI, AND LOBBY		KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––All registered Meeting Attendees are invited to come to the Welcome Reception to kick off ISID 2023!
Let's gather at the Welcome Reception to make the next three days even better.
This event is free of charge for registered ISID attendees and their companions.

Partial support of the Welcome Reception provided by Elsevier.

Future Leaders Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023
12:00-14:30
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction:
Dr. Erwin Tschachler, Editor in Chief, Journal of Investigative
Dermatology

LECTURES 2

LECTURES 1

Chair: Dr. Ritsuko Morita, Dr. Tae-Gyun Kim,
Dr. Chen-Hui Chen

COFFEE BREAK
12:50 - 13:10

Chair: Dr. Andrew Ji, Dr. Yingchao Xue, Dr. Jeremy Di Domizio,
Dr. Beatrice Dyring-Andersen

Proteomic pathways to personalized
medicine
Beatrice Dyring-Andersen, MD (ESDR)
Associate Professor
University of Copenhagen

Asynthetic fission in the zebrafish skinChen-Hui Chen, PhD (TSID)
Associate Research Fellow
Institute of Cellular and Organismic
Biology at Academia Sinica

Targeting skin type 3 immunity
through understanding the single-cellmicroenvironment
Tae-Gyun Kim, MD/PhD (KSID)
Assistant Professor
Yonsei University College of Medicine,
Severance Hospital
Republic of Korea

Skin Mechanobiology – Regenerationand More
Yingchao Xue, PhD (SID)
Postdoctoral-Fellow
Johns Hopkins University

Neutrophils drive skin autoinflammation
by releasing interleukin (IL)-26
Jeremy Di Domizio, PhD (ESDR)
Private Docent Research Scientist
University Hospital of Lausanne“Telescope model” for coordinatedorgan morphogenesis and stem cell
formation.
Ritsuko Morita, PhD (JSID)
Senior Scientist
RIKEN Center for Biosystems Dynamics
Research

Single-cell and spatial dissection ofhuman skin homeostasis and cancer.
Andrew Ji, MD (SID)
Assistant Professor
Icahn School of Medicine at Mount Sinai

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

17

LEO Foundation Awards––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023
14:30-15:00
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Join us at ISID 2023!
The winners of the LEO Foundation Awards
2023 will be announced live.
Let's pave the way for curing skin diseases.
The LEO Foundation is one of the world's largest funders of independent research into skin and skindiseases. The Foundation has given more than USD 140 million in grants and awards – in Denmark
and all over the world. Our philanthropic grants are awarded in open competition and are available toboth junior and senior researchers

Connect with us to find out when and how to apply for research funding:

Twitter

18

LinkedIn

leo-foundation.org

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGISID 2023 Opening Ceremony––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023
15:10 – 15:40
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––HOSTED BY:
Prof. Yukie Yamaguchi, Yokohama City University
Join the Leadership of the ISID and member organizations as they welcome attendees tothe first-ever ISID Meeting in Tokyo!
AGENDA:• Opening: Japanese drum ceremony(Mr. Keita Kanazashi, a professional Wadaiko (Japanese drum) performer)•

Welcome remarks from ISID Meeting Organizer, Professor Kenji Kabashima andCo-Host, Professor Dong-Youn Lee, President of the Korean Society for Investigative
Dermatology (KSID)•

Greetings from Dr. Russell Hall, ISID President•

Introduction of ISID Member Societies by Prof. Chris Griffiths
and Presidential Remarks

		
		
		
		

- Society for Investigative Dermatology (SID), Prof. Valentina Greco- European Society for Dermatological Research (ESDR), Prof. Sabine Eming- Taiwanese Society for Investigative Dermatology (TSID), Prof. Sung-Jan Lin- Australasian Society for Dermatology Research (ASDR), Prof. Johannes Kern•

Introduction of Science Council of Japan by Prof. Masayuki Amagai•

Greeting from the Meeting Co-Organizer: Koichi HISHIDA, Vice-President, Science
Council of Japan•

Presentation of a message from the Japanese Prime Minister, Fumio Kishida

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

19

Rising Stars Lectures––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023
15:40 – 16:40
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

15:40-16:00

16:00-16:20

16:20-16:40

Introduction by:
Prof. Eli Sprecher

Introduction by:
Dr. Kenji Kabashima

Introduction by:
Dr. Lynn Cornelius

Alexander Nystrom, PhD
University of Freiburg
Freiburg, Germany

Yumi Matsuoka-Nakamura, MD/PhD
Osaka University
Osaka, Japan

Shawn Demehri, MD/PhD
Massachusetts General Hospital
Boston, MA

The misunderstood matrix indermal fibrosis

Skin microbiota–host interactions inpediatric allergy and atopic dermatitis

Immunity to Commensal Virome
Regulating the Homeostasis ofAging Skin

Europe-Middle East-Africa
Region Rising Star

Asia/Oceania Region
Rising Star

America’s Region
Rising Star–––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––LECTURESHIP HISTORY
The 2023 Rising Stars Lectures celebrate the best of emerging dermatological science throughout the world. The ISID
2023 Committee on Scientific Programs have selected one prominent young researcher engaged in high-impact sciencein their respective region, to provide an overview of their current work.

20

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGAbbVie Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023
16:50 – 18:20
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Open Horizons: Up-to-Date Treatment Options for
Inflammatory Skin Diseases
16:50 – 16:55

Opening
Eung Ho Choi, MD/PhD, Professor, Department of Dermatology, Yonsei University,
South Korea

16:55 – 17:15

Bench to Bedside – AbbVie Development History
Annette Schwarz, DVM, DACVP, Senior Director Immunology Discovery Research,
AbbVie Global.
Dr. Schwarz leads the Pathology and late discovery GI and Rheumatology groups within
Abbvie Immunology Discovery Research. She graduated from Michigan State University
with both a B.S. in Physiology and D.V.M. After veterinary training, she was awarded an
EID research fellowship at the Centers for Disease Control and completed her Pathology
residency at Harvard University. She joined Abbott/Abbvie in 2002, driving studies tounderstand mechanisms of efficacy and potential toxicity for both small molecules (Jak,BTK, Syk) and protein therapeutics (TNF/17 DVD, IL-12). She led the targeted and conditional
immunocytokine platform including identifying disease specific epitopes and developing
translational quantitative imaging to understand the characteristics of targeted therapies indiseased tissue. Annette’s lab are technological innovators with state-of-the-art preclinicalimaging, spatialomics and AI/machine learning driven image analysis.

17:15 – 17:45

Biologics for Psoriasis and other diseases
Dr. Melinda Gooderham, MD. Dr. Gooderham is a Dermatologist and Medical Director at theSKiN Centre for Dermatology and an Investigator with Probity Medical Research.
She is an Assistant Professor at Queens University and a Consultant Physician at thePeterborough Regional Health Centre. She is a fellow of the Royal College of Physiciansand Surgeons of Canada. Dr. Gooderham has been the principal investigator for over 200
clinical trials and she practices with a focus on inflammatory diseases of the skin. She
also contributes to several peer-reviewed dermatology publications as an associate editor,
reviewer, and has been an author of 205 articles. She enjoys lecturing to global audiences on
new therapies for skin diseases.
				
17:45 – 18:15

JAKis for AD and other diseases
Melinda Gooderham, MD				
18:15 – 18:20

Closing
Eung Ho Choi, MD/PhD

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

21

Maruho Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
WEDNESDAY, MAY 10, 2023
16:50 – 18:20
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––The Birth of a Novel Treatment for Itching with IL-31RA Antibody
Importance of IL-31 signaling in pruritic skin diseases
Chair: Kenji Kabashima MD/PhD, Professor and Chair, Department of Dermatology, Kyoto
University Graduate School of Medicine, Kyoto, Japan
Speaker: Bernhard Homey MD, Professor and Chair, Department of Dermatology, Medical
Faculty, Heinrich-Heine-University, Duesseldorf, Germany. After his board certification indermatology and his specialisation in allergology, he received a Professorship for Dermatology
in 2003 and was appointed as Chairman of the Department of Dermatology at the University
Hospital Düsseldorf in 2010. Since 2014, he is the spokesperson of the University Allergy Centre
Düsseldorf. He has a long-standing research interest in all aspects of skin inflammation andduring recent years, a focus has been directed towards the interplay of the microbiome with the
host’s immune and nervous systems.

Characterization of sensory nerves transmitting itch during skin barrier impairment andinflammation
Chair: Lisa A. Beck MD, Professor, Department of Dermatology, Medicine and Pathology,
University of Rochester Medical Center, Rochester, NY, USA
Speaker: Takaharu Okada PhD, Laboratory for Tissue Dynamics, RIKEN Center for Integrative
Medical Sciences, Yokohama, Kanagawa, Japan. Dr. Okada received his PhD degree from the
School of Life Science, Graduate University for Advanced Studies. The goal of his laboratory
is to understand the mechanisms regulating cell migration and interactions in the tissues thatshape adaptive immune responses. For this purpose, they use real time imaging, in particular
two-photon microscopy, to analyze cellular migration and interactions in the tissues. By applying
the imaging strategy to relevant mouse models, they aim to reveal immune cell dynamics thatare critical for generation of immunological memory and tolerance, two important features ofadaptive immunity. In addition, as a most recent focus, they are also studying the function ofprimary sensory nerves during the development of atopic dermatitis.

Understanding the role of IL31 as a target for atopic dermatitis
Chair: Norito Katoh MD/PhD, Professor and Chair, Department of Dermatology, Kyoto Prefectural
Medical University, Kyoto, Japan
Speaker: Gil Yosipovitch MD, Professor, Department of Dermatology and Cutaneous Surgery,
University of Miami Miller School of Medicine, Miami, Florida, USA. Dr. Yosipovitch is the Directorof the Miami Itch Center. He has published more than 550 articles in books and peer reviewed
journals and has edited 5 books. He is the founder and past President of the International Forumfor the Study of Itch and member of its board. He served as Chairman of the Scientific Board of
the National Eczema Association. He serves on the editorial boards of 6 key specialty journals.
He has received numerous awards and funds for his work. Dr. Yosipovitch has given morethan 500 invited lectures to dermatology groups and organizations around the world and has
mentored more than 50 fellows, PhD students and post-Doc fellows.

22

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

THURSDAY

MAY 11, 2023

THURSDAYISID 2023 Social Gathering––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
19:50 –21:50
ROOM A: CONCORD BALLROOM & ROOM B: EMINENCE HALL		
KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Get ready for one of the biggest and most spectacular events of ISID 2023 where you will enjoy a traditional
Japanese festival “Matsuri”!!
This is a Ticketed Event: Pre-registration is required. Please visit the ISID 2023 Meeting Registration
Counter in the Room HANA C/D for availability.

Maiko will be waiting for everyone to join. Join in the fun with Japanese culture, games, and food.
See you there!

Japan Blood Products Organization Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
07:00 – 08:00
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Dermatomyositis
Chair:
Manabu Fujimoto, MD/PhD, Professor, Dermatology Department of Integrated Medicine,
Graduate School of Medicine Osaka University, Osaka, Japan.

Single cell analysis and the role of cytokines in dermatomyositis
Victoria P. Werth, MD, Professor, Department of Dermatology, University of Pennsylvania,
Chief, Division of Dermatology, Veterans Administration Medical Center, Philadelphia, USA.
Dr. Werth earned her medical degree from Johns Hopkins University School of Medicine. She
joined the faculty at Penn in 1989 and has developed an internationally recognized programin autoimmune skin diseases. She is a co-founder of the Rheumatologic Dermatology Society
and previous president of the group. She is co-founder of the Medical Dermatology Society,and a recipient of their lifetime achievement award. She has a longstanding interest in clinicaland translational research pertaining to autoimmune skin diseases, including cutaneous
lupus erythematosus, dermatomyositis, and autoimmune blistering diseases, with a focus on
improving the outcomes of autoimmune dermatologic diseases.

Novel autoantigens in cancer associated dermatomyositis
David Fiorentino, MD/PhD, Professor, Department of Dermatology, Department of Medicine,
Division of Rheumatology, Stanford University School of Medicine, Palo Alto, USA.
David Fiorentino is a Professor in the Department of Dermatology at Stanford School of
Medicine where he has been since 2002. He is the also the Associate Program Director
and has co-directed a multidisciplinary dermatology-rheumatology clinic since 2004. Hespecializes in the treatment of patients with rheumatic skin disease, with a focus ondermatomyositis and scleroderma. His research interests are mostly within dermatomyositis,and he is particularly focused on identifying novel autoantigens and their clinical associations
as well as their role in disease pathogenesis. He also conducts clinical trials for patientswith dermatomyositis and scleroderma and is a founding member and past president of theRheumatologic Dermatology Society.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

25

Otsuka Pharmaceutical Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
07:00 – 08:00
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Pathophysiology of Atopic Dermatitis
CHAIRS:
Takeshi Nakahara, MD/PhD, Professor, Department of Dermatology, Graduate School of
Medical Sciences, Kyushu University, Fukuoka, Japan.
Hiroyuki Murota, MD/PhD, Professor, Department of Dermatology, Nagasaki University
Graduate School of Biomedical Sciences, Nagasaki, Japan.

PDE4 inhibition by difamilast regulates filaggrin and loricrin expression via keratinocyte
proline-rich protein in human keratinocytes.
Gaku Tsuji, MD/PhD, Associate Professor, Research and Clinical Center for Yusho andDioxin, Kyushu University Hospital, Fukuoka, Japan.
Dr. Tsuji received his MD degree from Tottori University Faculty of Medicine, and his PhD
degree from the Graduate School of Medical Sciences, Kyushu University. After completing
his residency at the Department of Dermatology, Graduate School of Medical Sciences,
Kyushu University., he was a Visiting Fellow at the Dermatology Branch in the NIH. He wasappointed as an Associate Professor in 2019.

Basophils in the pathogenesis of atopic dermatitis
Hajime Karasuyama, MD/PhD, Distinguished Professor, Tokyo Medical and Dental University(TMDU) Advanced Research Institute, Inflammation Infection and Immunity Laboratory,
Tokyo, Japan.
Dr. Karasuyama received his MD degree from Tokyo Medical and Dental University, and his
PhD degree from the University of Tokyo. Dr. Karasuyama's research is to understand thephysiological and pathological roles for basophils in various immune and inflammatory
responses, and to apply this knowledge to the development of novel therapeutics for
inflammatory disorders.

26

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGKaken Pharmaceutical Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
07:00 – 08:00
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––New Findings on Terbinafine-resistant Dermatophytosis
CHAIR:
Kazutoshi Harada, MD/PhD, Professor & Chair, Department of Dermatology, Tokyo Medical
University, Tokyo, Japan.

New findings on terbinafine-resistant dermatophytosis: Epidemiology, resistancemechanisms, and prevention methods
Rui Kano, DVM/PhD, Professor, Teikyo University Institute of Medical Mycology, Tokyo,
Japan.
Dr. Kano received his education from 1988-1994 at the Nihon University School of Veterinary
Medicine, from 1994-1996 at the Animal Hospital, School of Veterinary Medicine, Faculty ofAgriculture, University of Tokyo, Japan; 1996 – 1999 Dermatology, Teikyo University School of
Medicine, Tokyo; and from 2007 – 2008 served as a Guest Researcher at Center for Disease
Control and Prevention (CDC), USA. His areas of research interest are animal mycoses,
molecular taxonomy of fungi, and antifungal resistance.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

27

Taisho Pharmaceutical Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
07:00 – 08:00
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Visualization of vascular network in the skin and brain enables
the understanding of stem cell niche -Cross-talk system between"vasculature" and "hair cycle/minoxidil/skin homeostasis”
CHAIR
Manabu Ohyama, MD/PhD, Professor and Chair, Department of Dermatology, Kyorin
University Faculty of Medicine, Tokyo, Japan.

SPEAKER
Ken-ichi Mizutani, PhD, Research Professor, the Graduate School of Pharmaceutical
Sciences, Kobe Gakuin University.
Ken-ichi Mizutani received his PhD degree in Human and Environmental Studies from the
Kyoto University, Japan, in 2002. From 2002 to 2009, he was a research scientist at Institutefor Frontier Medical Sciences, Kyoto University, Department of Neurology, Johns Hopkins
University School of Medicine, and RIKEN Center for Developmental Biology. In 2010, hejoined the Graduate School of Brain Science, Doshisha University, as an Associate Professor.
From 2010 to 2013, he was a PRESTO research scientist (concurrent) at Japan Science andTechnology Agency. From 2017, he is working at Graduate School of Pharmaceutical Sciences,
Kobe Gakuin University as a Research Professor. His research interests include stem cellbiology, neurogenesis, angiogenesis, brain science, dermatology, and vascular aging inhibitor/
anti-aging material. He has received several academic awards as the first author including
the Young Investigators Award of the Society for the Spontaneously Hypertensive Rat(2002), Promotion Award for Young Investigators of the International Hypertension Society(2002), and Young Investigator Okamoto Award of the Japan Research Foundation for
Healthy Aging (2007).

28

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGAMRYT Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
07:00 – 08:00
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Epidermolysis Bullosa – Concepts for Change
07:00 Opening Remarks – Chair. The Complexity of EB, John McGrath, MD FRCP FMedSci,
Professor and Mary Dunhill Chair in Cutaneous Medicine and Academic Head, St John’s
Institute of Dermatology, King’s College London, UK. Dr McGrath is the academic head of
St John’s Institute of Dermatology in London where he also runs the Genetic Skin Disease
Group. He also currently holds a Yu-Shan Fellowship at the National Cheng Kung University
in Taiwan. He has had lead roles in delivering experimental medicine and precision medicine
within the U.K. translational research program. His own research focuses on the molecularcharacterization of inherited skin diseases and the development of novel treatments forrare disorders. He has carried out first-in-man trials of cell therapies (allogeneic fibroblasts,
mesenchymal stromal cells) and gene therapies (autologous gene-corrected fibroblasts)
for patients with inherited skin diseases, particularly epidermolysis bullosa, and continues
to develop translational research involving gene, cell, protein, and small molecule-based
therapeutic approaches.
07:05 EB Wounds - A Fundamental Priority, Mauricio Torres-Pradilla, MD, Professor of
Pediatric Dermatology, Fundación Universitario de Ciencias de la Salud, Hospital de San
José and Hospital Infantil Universitario de San José, Bogota, Colombia. Dr Torres is a
researcher in epidermolysis bullosa, vascular tumours, psoriasis and atopic dermatitis.
He is Vice President of the Colombian Association of Pediatric Dermatology (ACDP), he’sa member of DEBRA Colombia, the Colombian Association of Dermatology, the Colombian
Association of Pediatric Dermatology (ACDP), the Society of Pediatric Dermatology (SPD),the International Society of Pediatric Dermatology (ISDP) and the Latin American College of
Dermatology (CILAD).
07:10 Approaching a New Era for Patients with EB, John McGrath, UK
07:20 Defining and Measuring Patient Outcomes, Dedee Murrell, MD, Professor & Head,
Department of Dermatology, St George Hospital, University of NSW, Sydney, Australia. Dr
Murrell is Professor of Dermatology at the University of NSW and Head of the Departmentof Dermatology at St George Hospital, Sydney, Australia. She is also Honorary Professorial
Fellow at the George Institute for Global Health, Sydney. She specialises in novel therapeutics
in medical dermatology in adults and children. She has developed and validated outcome
measures for blistering diseases and epidermolysis bullosa. She directs a clinical trials
centre with expertise in these diseases as well as trials on atopic dermatitis, psoriasis,alopecia, vitiligo, acne and skin cancer.
07:35 Translating Clinical Studies into Clinical Practice, Mauricio Torres, MD, Colombia
07:45 Panel Discussion and Audience Questions
Closing Remarks, John McGrath, UK

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

29

Plenary Session 1––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
08:10 – 09:10
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Prof. Kenji Kabashima, Dr. Rhoda Alani, Prof. Marta Szell
08:10-08:22

ORAL 001 [POSTER 1497]

Type 2-mediated oxidative reprogramming promotes the transitionof macrophages into repair mode and is required for wound healing
S. Willenborg1, D. E. Sanin2, E. J. Pearce2, A. Trifunovic3, H. Kashkar3,
S. A. Eming1, 3
1
Universitat zu Koln, Cologne, Germany, 2Johns Hopkins University,
Baltimore, Maryland, United States, 3Exzellenzcluster CECAD in derUniversitat zu Koln, Cologne, Germany
08:22 -08:34

ORAL 002 [POSTER 603]

Degradation of aberrant NETs by DNases is a promising therapeuticstrategy for SJS/TEN
M. Kinoshita1, Y. Ogawa1, N. Hama2, A. Hasegawa2, S. Shimada1,
R. Abe2, T. Kawamura1
1
University of Yamanashi, Yamanashi, Japan, 2Niigata University, Niigata,Japan
08:34-08:46

ORAL 003 [POSTER 187]

Recurrent neural networks to predict biologic treatment outcomes inpsoriasis
A. Hussain1, C. Atallah1, C. Griffiths2, 3, R. B. Warren2, 3, S. Dlay1,
N. Reynolds1, 3
1Newcastle University, Newcastle upon Tyne, United Kingdom,2
Dermatology Centre, The University of Manchester, Manchester, United
Kingdom, 3BADBIR study group, Manchester, United Kingdom

30

08:46-08:58

ORAL 004 [POSTER 180]

Immune-mesenchymal crosstalk contribute to expansion of
autoreactive plasma cells in the tertiary lymphoid structures inhidradenitis suppurativa
W. Yu1, 2, J. Barrett1, J. Tong1, M. Lin1, J. C. Devlin3, 4, A. Herrera5,
M. Marohn1, J. Remark1, 4, P. Liu6, J. Krueger7, K. V. Ruggles3, 8,
S. B. Koralov5, E. S. Chiu1, C. Lu1, 9
1Plastic Surgery, New York University, New York, New York, UnitedStates, 2Department of Dermatology, Kaohsiung Veterans General
Hospital, Kaohsiung, Taiwan, 3Institute of Systems Genetics, New York
University Grossman School of Medicine, New York, New York, UnitedStates, 4Vilcek Institute of Graduate Biomedical Sciences, New York
University Grossman School of Medicine, New York, New York, UnitedStates, 5Department of Pathology, New York University Grossman
School of Medicine, New York, New York, United States, 6Departmentof Ophthalmology, Kaohsiung Medical University, Kaohsiung, Taiwan,
7
Laboratory of Investigative Dermatology, The Rockefeller University,
New York, New York, United States, 8Division of Translational Medicine,
Department of Medicine, New York University Grossman School of
Medicine, New York, New York, United States, 9Department of Cell
Biology, New York University Grossman School of Medicine, New York,New York, United States

08:58-09:10

ORAL 005 [POSTER 321]

A human tissue model of Darier disease reveals MEK as a novel
therapeutic target downstream of SERCA2 deficiency
S. A. Zaver1, M. Sarkar2, A. Tiwaa1, J. Zou3, S. Egolf3, B. Capell3,
J. Gudjonsson2, C. L. Simpson1
1
Dermatology, University of Washington School of Medicine, Seattle,
Washington, United States, 2Dermatology, University of Michigan, Ann
Arbor, Michigan, United States, 3Dermatology, University of Pennsylvania,
Philadelphia, Pennsylvania, United States

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGSID William Montagna Lecture

Neuroimmune Mechanisms Underlying Atopic
Dermatitis Itch and Inflammation––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
09:15 – 09:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Elena Ezhkova

Diana Bautista, PhD
University of California, Berkley, Berkley, CA
Diana Bautista is the Class of 1943 Memorial Chair and Professor of Celland Developmental Biology and of Neurobiology in the Department of
Molecular and Cell Biology and the Helen Wills Neuroscience Institute at
the University of California, Berkeley. She received her bachelor’s degreein Biology & Biochemistry from the University of Oregon, her Ph.D. in
Neuroscience from Stanford University with Dr. Richard S. Lewis andwas a postdoctoral fellow in Physiology at the University of California,
San Francisco with Dr. David Julius. She joined the faculty at UC Berkeley
in 2008.
Dr. Bautista’s lab studies the molecular and cellular mechanisms of itch,
touch, and pain, under normal and disease conditions. Her research has
been funded by the NIH since 2009 and her work has been recognizedby numerous awards, including a 2009 Pew Scholar Award, the 2014Society for Neuroscience Young Investigator Award, a 2016 Howard
Hughes Medical Institute Scholar Award and a 2019 NIH Director'sTransformative Research Award. In 2022 she became a Howard
Hughes Medical Institute Investigator. Her current research is focusedon neuroimmune interactions in persistent pain, itch, and inflammatory
disease.

LECTURESHIP HISTORY
The William Montagna Lecture is given annually at the Society’s Annual
Meeting. This award is intended to honor and reward young active
investigators. Primary emphasis is given to researchers in skin biology.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

31

JSID Special Guest Lecture

Recent Progress in iPS Cell Research and Application––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
09:45 – 10:15
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Prof. Masayuki Amagai

Shinya Yamanaka, MD/PhD
Kyoto University, Kyoto, Japan
Dr. Shinya Yamanaka is the Director of the Center for iPS Cell Researchand Application (CiRA), Kyoto University and a Senior Investigatorand the L.K. Whittier Foundation Investigator in Stem Cell Biology at
the Gladstone Institute for Cardiovascular Disease (GICD). He is alsoa Representative Director of Public Interest Incorporated Foundation,
CiRA Foundation. He earned an MD from Kobe University in 1987 anda PhD from Osaka City University in 1993. From 1987 to 1989, he was a
resident at the National Osaka Hospital. From 1993 to 1996, he was a
postdoctoral fellow at GICD.
In 1996, He became an Assistant Professor at Osaka City University
Medical School. In 1999, he was appointed Associate Professor at Nara
Institute of Science and Technology, where he became a full professor
in 2003. He took his current position as professor at Kyoto University in2004 and was appointed Senior Investigator at the Gladstone Institutes
in 2007.
Since 2008, he has directed CiRA. He is most recognized for his original
research on induced pluripotent stem (iPS) cells. Since his breakthroughfinding, he has been the recipient of many prestigious awards, including
the Nobel Prize in Physiology or Medicine jointly with Dr. John Gurdon(2012). Human iPS cells and their derivatives offer a new model for
disease modeling, drug discovery, and regenerative medicine.
His primary vision is to overcome diseases by delivering iPS cell-based
innovative therapeutic options.

32

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGPlenary Session 2––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
10:20 – 11:20
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Prof. Dongyoun Lee, Dr. Johann Gudjonsson, Prof. Neil Rajan
10:20-10:32

ORAL 006 [POSTER 414]

Identification of metagenes for prediction of therapeutic efficacy
and disease monitoring by decomposing atopic dermatitis skinmRNA-seq data
A. Fukushima-Nomura1, H. Kawasaki1, 2, K. Tanese1, E. Kawakami3,
M. Amagai11
Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Center
for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Advanced
Data Science Project, RIKEN, Yokohama, Japan

10:32-10:44

ORAL 007 [POSTER 694]

Keratinocyte autophagy deficiency aggravates itch-related scratchingin atopic dermatitis
G. Peng1, 2, W. Zhao2, K. Okumura2, H. Ogawa2, S. Ikeda1, 2,
F. Niyonsaba2, 3
1
Department of Dermatology and Allergology, Juntendo University
Graduate School of Medicine, Tokyo, Japan, 2Atopy (Allergy) ResearchCenter, Juntendo University Graduate School of Medicine, Tokyo, Japan,
3
Faculty of International Liberal Arts, Juntendo Daigaku, Tokyo, Japan

10:44 -10:56

10:56-11:08

ORAL 009 [POSTER 866]

A single nucleotide activity map of skin disease variants andtranscription factors that modulate them
D. Porter, D. L. Reynolds, R. Meyers, W. Miao, A. W. Hong, X. Yang, L.
Ducoli, S. Mondal, Z. Siprashvili, I. Elfaki, S. Srinivasan, P. A. Khavari
Dermatology, Stanford University, Stanford, California, United States

11:08-11:20

ORAL 010 [POSTER 1315]

Differential response of 3D African American and White Non-Hispanic
skin organoids to major pro-inflammatory cytokines
I. Budunova1, D. Trubetskoy1, A. Klopot1, B. Shi1, L. C. Tsoi2,
B. E. Perez White1
1
Dermatology, Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States, 2Dermatology, University of Michigan,
Ann Arbor, Michigan, United States

ORAL 008 [POSTER 287]

Investigating drivers of disease progression in cutaneous squamouscell carcinoma
M. Treanor-Taylor1, 2, L. Mcgarry1, 2, L. Carlin1, 2, C. Harwood3, I. Leigh3,
P. Bailey1, 2, G. Inman1, 2
1Cancer Research UK Beatson Institute, Glasgow, United Kingdom,
2
University of Glasgow, Glasgow, Scotland, United Kingdom, 3Queen
Mary University of London, London, United Kingdom

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

33

Stephen I. Katz MD/PhD Memorial Lectureship Award

Immune-tissue Crosstalk during Homeostasis and Disease––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
11:20 – 11:50
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Prof. Shinji Shimada

Keisuke (Chris) Nagao, MD/PhD
National Institutes of Health (NIH), Bethesda, MD
Dr. Nagao is a board-certified Dermatologist (Japanese Association of
Dermatology) and currently directs a research program that includes
basic and pre-translational investigations on skin immunology andimmune-mediated diseases. Dr. Nagao is an attending physician on the
NIH Clinical Center’s Dermatology Consultation Service.
Dr. Nagao studies the skin immune system in the context of hostmicrobiota crosstalk during health and inflammatory conditions and has
advanced our knowledge on how the skin functions as an immunologicalorgan.
His laboratory has identified hair follicles as control towers of the skinimmunity that support the tissue-residency and localization of dendritic
cells, T cells, and innate lymphoid cells. In turn, the immune cells, suchas the innate lymphoid cells, actively communicate with the hair follicles
to regulate the commensal bacteria on the skin surface. Dr. Nagao’s
laboratory has also generated a mouse model for atopic dermatitis anddemonstrated Staphylococcus aureus to be a critical element during
eczema formation.
In collaboration with investigators at the NIH Clinical Center, he conducts
translational research on intractable inflammatory skin diseases, suchas primary immunodeficiencies, to understand mechanisms that
underlie host-microbial symbiosis directly in humans.

34

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGUCB Medical Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Understanding Hidradenitis Suppurativa: an Educational Symposium
CHAIRS:
Kenji Kabashima, MD/PhD, Professor and Chair, Department of Dermatology, Kyoto
University Graduate School of Medicine, Kyoto, Japan.
Nicole Ward, PhD, Vice Chair for Basic Research, Department of Dermatology; Professor of
Dermatology; Professor of Pathology, Microbiology and Immunology, Vanderbilt University
Medical Center, Nashville, US.

Introducing HS: what does psoriatic disease tell us about the drivers of inflammation?
Stevan Shaw, PhD, VP Head of Immunology Research, UCB, UK.
Dr. Shaw is currently Head of Immunology Research responsible for strategy and execution of
a portfolio of immunology projects from target identification through to candidate selection
and senior member of the Immuno-Bone Therapeutic area Leadership team responsible forstrategy and execution from candidate to clinical proof of concept. He has over 25 yearsexperience in the discovery & development of novel therapeutics for patients with severe
Immunological diseases, and led multiple therapeutic based projects from target identification
through to proof of concept clinical studies (Bimekizumab, Olokizumab, Rozanolixizumab,).
He is also an inventor on multiple patents.

Understanding HS: what have we uncovered about its complex pathophysiology?
James Krueger, MD/PhD, Laboratory for Investigative Dermatology, The Rockefeller
University, New York, USA.
Dr. Krueger is Head of the Laboratory for Investigative Dermatology at The Rockefeller
University in New York, NY, USA. He also serves as Physician and Co-director of the Centerfor Clinical and Translational Science at the Rockefeller University Hospital, and as Chief
Executive Officer of the Rockefeller University Hospital. Dr Krueger earned his PhD degree invirology and cell biology from The Rockefeller University. He received his medical degree from
Cornell University Medical College (New York City), where he also completed an internship ininternal medicine and a residency in dermatology.

Managing HS: where are we now and where do we aim to be?
Kenzo Takahashi, MD/PhD, Professor and Chair, Department of Dermatology, University of
the Ryukyus Graduate School of Medicine, Okinawa, Japan.
Dr. Takahashi received his MD degree from Kyoto University School of Medicine, Kyoto
University, Kyoto, Japan. He continued at the University of Kyoto and received his PhD degree.
He completed a Postdoctoral Fellowship in the lab of Pierre Coloumbe, PhD in Johns Hopkins
University school of Medicine, Maryland. He joined the University of the Ryukyus School of
Medicine in 2010, and in 2022, was appointed as Dean of the School of Medicine.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

35

Taiho Pharmaceutical/Janssen Pharmaceutical K. K. Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Pathophysiology of Psoriasis and the Role of IL-23
CHAIR:
Yoshihide Asano, MD/PhD, Professor and Chair, Department of Dermatology, Tohoku
University Graduate School of Medicine, Sendai, JAPAN.

SPEAKER:
Tetsuya Honda, MD/PhD, Professor and Chair, Department of Dermatology, Hamamatsu
University School of Medicine, Hamamatsu, JAPAN.
Dr. Honda received his MD degree in 2000 and PhD in 2007 from Kyoto University, Kyoto,
Japan. He was assigned as an Assistant Professor at Kyoto University (2007–2010) and a
Visiting Fellow at the National Institutes of Health, Bethesda (2010–2012). After returning
to Japan, he served as an Associate Professor (2012–2015) at Department of Innovation
Center for Immunoregulation Technologies and Drugs at Kyoto University, then as Assistantprofessor in the Department of Dermatology at Kyoto University(2015-2020). He wasappointed as Professor in the Department of Dermatology at Hamamatsu University Schoolof Medicine in 2020.

36

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Bristol Myers Squibb Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––A New Pathway for Psoriasis Treatment
CHAIR:
Akiharu Kubo, MD/PhD, Professor, Department of Dermatology, Kobe University Graduate
School of Medicine, Kobe, JAPAN.

SPEAKER:
Positioning of Deucravacitinib in Psoriasis Treatment		Yukie Yamaguchi, MD/PhD, Professor and Chair, Department of Environmental ImmunoDermatology, Yokohama City University Graduate School of Medicine, Yokohama, JAPAN.
Dr Yamaguchi is a professor and chairman at Department of Environmental ImmunoDermatology at Yokohama City University Graduate School of Medicine. She received her Md
degree from Hamamatsu University School of Medicine, and her PhD degree from Yokohama
City University, Graduate School of Medicine. Her research focuses on psoriasis, connective
tissue diseases, cutaneous immunology, extracellular matrix.

CHAIR:
Ryuhei Okuyama, MD/PhD, Professor, Department of Dermatology, Shinshu University
Graduate School of Medicine, Nagano, JAPAN.
SPEAKER:
Differentiation of SOTYKTU from pan-JAKis - mechanisms to basic science
Johann Gudjonsson, MD/PhD, Professor, Department of Dermatology, Arthur C. Curtis
Professor, Molecular Skin Immunology, Frances, Kenneth Eisenberg Emerging Scholar of
the Taubman Medical Research Institute, University of Michigan, Ann Arbor, USA.
Dr. Gudjonsson's primary research focus is basic immunological and genetic research on
chronic inflammatory skin diseases, including Hidradenitis Suppurativa. He has publishedover 240 peer-reviewed papers in top-tier journals, and his work has earned several researchawards, including awards from the American Skin Association, and Doris Duke Foundation,
and was selected as the Society for Investigative Dermatology Rising Star Lecture in 2018. He
was elected to the American Society for Clinical Investigation (ASCI) in 2020.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

37

Pfizer Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

JAK and Other Kinase Inhibitors in Dermatology:
Dawn of a New Therapeutic Era
OBJECTIVES• Explore the role of the JAK-STAT and other kinase pathways in the complex pathophysiology
of immuno-inflammatory dermatological diseases• Highlight the potential of using JAK selectivity to match molecules to immuno-inflammatory
dermatological diseases driven by specific cytokine profiles• Review the topical and systemic kinase inhibitors in development for the treatment of
immuno-inflammatory dermatological diseases, including atopic dermatitis, alopecia
areata and vitiligo

AGENDA
12:05 PM – 12:10 PM

Welcome and Introductions
Melinda Gooderham
12:10 PM – 12:30 PM

Kinase Pathways: Gateway to Understanding Immuno-Inflammatory
Dermatological Diseases
Melinda Gooderham
12:30 PM – 12:50 PM

The Therapeutic Potential of a New Drug Class: Kinase inhibitors in Dermatology
Thierry Passeron
12:50 PM – 13:05 PM

Panel Discussion / Q&AAll

38

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Amorepacific Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Skin Epigenetics - Sulwhasoo Symposium
CHAIR:
Prof. Jin Ho Chung, Department of Dermatology, Seoul National University College ofMedicine

Epigenetic Landscape of Skin Aging
Sewon Kang, MD, Noxell Professor & Chairman, Department of Dermatology, Johns Hopkins
University School of Medicine.
Dr. Kang is founder and co-Director of the Cutaneous Translational Research Program(CTReP) at Hopkins. A recipient of the Dermatology Foundation's Career Development
Award, he has received other research awards and grants from the American Dermatological
Association, the National Psoriasis Foundation and the National Institutes of Health. His
research focus has been in the areas of skin pharmacology and photomedicine. He is the
Past President of the Photomedicine Society, and the American Acne and Rosacea Society.
Dr. Kang is or has been on the Board of Directors of multiple organizations including, theSociety for Investigative Dermatology, the Association of Professors of Dermatology, theDermatology Foundation, and the Skin of Color Society. An author on over 240 publications
and book chapters, Dr. Kang is also the Editor-in-Chief of the 9th edition of the Fitzpatrick's
Dermatology textbook. He is an inventor/co-inventor of 17 patents and has given over 300
presentations globally.

Advanced epigenetic regulation for skin anti-aging
Kyu-Han Kim, PhD, Sulwhasoo Heritage & Science Center, Research and Innovation Center,
AMOREPACIFIC.
Dr. Kim has been investigating the discovery of epigenetic biomarkers such as microRNAfor skin aging and epigenetic mechanism of anti-aging cosmetic ingredients at R&I centerof AMOREPACIFIC. In recent years, he has been focusing on the research of epigenetic
regulation of skin aging using the state-of-the-art bioinformatics including network analysis
and machine learning tools, and thus finding the newly effective solution for skin anti-aging.
He has authored or coauthored several high-impact research articles published in Nucleic
Acids Res, J Invest Dermatol, Exp Mol Med, J Allergy Clin Immunol and other journal

Moderator
Beom Shim, PhD, New Beauty Research Initiative, AMOREPACIFIC R&I Center

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

39

CHANEL Fragrance & Beauty Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Senescence: The Global Approach to Skin Aging
CHAIRS:
Youcef Ben Khalifa, PhD, CHANEL PB, FRANCE

Dr. Ben Khalifa has 18 years of experience in health and cosmetic fields. He obtained his PhD in 2008
in molecular biology and cancer research at the University of Medicine of Paris XI. He did his PhD at the
Pasteur Institute in Paris and A*START, Agency of Science Technology and research, in Singapore followed
by a 1st post-doc working on Papillomavirus, Skin Warts and Cervix Cancer. In 2011 he moved back to Parisat the Pasteur Institute for a 2nd post-doc within the European project SILVER identifying small molecules
inhibitors of rabies virus. In 2014 he joined the cosmetic field at L’Oréal as Project Manager and then as
Head of Cell and Tissue Engineering Research laboratory. Since 2021, he was appointed as the Directorof Beauty Research and Performance at CHANEL developing the Research and Innovation strategy in thefields of Skin Biology, Neurosciences, and cosmetics performance evaluation.

Florian Gruber, PhD, Associate Professor, Department of Dermatology, Medical Universityof Vienna, AUSTRIASPEAKERS:
Analytic Imaging of Senescence - Induced Changes in Lipid and Carbohydrate Metabolism
Florian Gruber, PhD, Associate Professor, Department of Dermatology, Medical University of
Vienna, AUSTRIA. Dr. Gruber was trained as a molecular biologist at the University of Vienna, Harvard

College, and the University of Virginia, and received his venia docendi for experimental dermatology in
2019. In 2020 he became Director of the Christian Doppler Laboratory for Multimodal Analytical Imaging
of Aging and Senescence – SKINMAGINE –, a shared public and corporate venture for investigation of therole of senescent cells in skin aging which is headquartered at the Medical University of Vienna. Together
with research groups at the University of Natural Resources and Life Sciences, the Technical University of
Vienna, and the corporate partner Chanel FB, Florian Gruber investigates with an integrated and correlated
analytical imaging approach how the (epi-) lipidome, the epi-transcriptome and metabolism are adaptedin aging tissue.

Impact of Cellular Senescence in Aging Pigmentation 				Hee Young Kang MD/PhD, Professor and Chair, Department of Dermatology, Ajou University
School of Medicine, Suwon, KOREA. Dr. Kang received both her MD and PhD degrees from the Ajou

University School of Medicine. She studied at the department of life science of POSTECH, Korea (19951997). She trained in dermatology at the Ajou University Hospital (1997-2001). In 2001, she became board
certified dermatologist in 2001 and worked as an assistant professor in the department of dermatology,
Ajou University School of Medicine from 2004 to 2008. She was a visiting scholar in department ofdermatology at the University of Nice in France (2008-2009). She has published scientific and clinicalpapers in more than 150 highly ranked international journals. Besides clinical dermatology, her scientificfocus is in the pigmentary disorders including melasma and vitiligo and skin aging.

Cosmetic Application: CHANEL Natural ingredients Regulating Senescence Pathways for
Unmatched Anti-aging Benefits of our Products 				Sandra Forestier, PhD, CHANEL PB, FRANCE. Dr. Forestier has a PhD degree in Cutaneous
Biology (University of Jussieu, Paris VI). She has 18 years of experience in Cosmetic industry, inthe development of innovative skincare products. She joined CHANEL in 2005 as active ingredient project
manager. In 2009, she was appointed responsible of active ingredient selection department. In 2018,
she was in charge of Biology Research: the discovery of new biological targets, the evaluation of active
ingredient efficacy by in vitro tests on skin cell cultures and reconstructed human skin models and the
set-up of international scientific partnerships. Since 2020, she leads biological and clinical researchstudies, to analyze and understand skin specificities from cellular to clinical level.

40

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGGalderma Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
12:05 – 13:05
ROOM G: TAKAO, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Targeting itch and beyond: IL-31, a central neuroimmune mediatorin atopic dermatitis and prurigo nodularis
12:05–12:08

Chair’s welcome and introduction
Prof. Lisa Beck, MD (USA) Professor Beck is Co-Director of the University of Rochester
Medical Center (URMC) for Allergic Disease Research, which was chosen as one of four
US centers with the World Allergy Organization’s Center of Excellence designation. She has
been the Secretary of the International Eczema Council since its inception, Emeritus Memberof the National Eczema Association Scientific Advisory Committee, and Past President of
the Society for Investigative Dermatology. As Founding Director of the URMC Dermatology
Clinical Trials Unit, Professor Beck has completed >14 clinical atopic dermatitis (AD) studies,that include mechanistic, interventional and registry trials, all of which met or exceeded
enrollment/retention expectations and has a URMC AD patient registry with over 4000
patients. Professor Beck has also been Co-Primary Investigator of the Atopic Dermatitis
Research Network (ADRN) since its inception, which has amassed the largest cross-sectional
registry of phenotyped AD subjects in the world.
12:08–12:20

The torment of itch: Understanding the invisible symptom
Prof. Lisa Beck, MD (USA)
12:20–12:35

IL-31 signaling: Neuroimmune mediation in itch, inflammation and epithelial structure
Bernhard Homey, MD is Director of the Department of Dermatology at the University Hospital
Düsseldorf, Germany. After his board certification in dermatology and his specialisation inallergology, he received a Professorship for Dermatology in 2003 and was appointed as
Chairman of the Department of Dermatology at the University Hospital Düsseldorf in 2010.
Since 2014, he is the spokesperson of the University Allergy Centre Düsseldorf. Professor
Homey has a long-standing research interest in all aspects of skin inflammation and during
recent years, a focus has been directed towards the interplay of the microbiome with the host’s
immune and nervous systems. Professor Homey has received several honours, including
the Paul Martini Award, Oscar Gans Award, Günther-Wille Award and the Fujisawa Atopic
Dermatitis Award. He participates in notable national and European research networks.
12:35–12:50

The unique role of IL-31: Uncovering the pathophysiology of atopic dermatitis and prurigo
nodularis
Lam C. (Alex) Tsoi, PhD, Assistant Professor, Dermatology, Assistant Professor,
Computational Medicine and Bioinformatics, Research Assistant Professor, Biostatistics,
University of Michigan, Department of Dermatology, Ann Arbor, MI. Dr. Tsoi completed
his PhD in biomedical science at the Medical University of South Carolina, supervised by
Dr. W Jim Zheng. His PhD work focused on developing data integration approaches toenhance prioritization and interpretation of high throughput experimental results. Dr. Tsoi
has strong interests in investigating the pathology and genetic architecture of complex
cutaneous disorders using systems biology approaches. Working with Drs. James T. Elderand Johann E Gudjonsson, Dr. Tsoi’s research aims to develop analysis pipelines andcomputational approaches to provide biological inferences from genetics and genomics
data. His work in genetic association studies revealed over 30 novel psoriasis susceptibility
regions, and highlighted different disease pathways. He also led the analysis and developed
computational pipeline to study psoriasis transcriptomes, and his work uncovered over 1,000
novel transcripts in skin.
12:50–13:05

Panel discussion and close
All; facilitated by Prof. Lisa Beck, MD (USA)

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

41

Concurrent Mini-Symposium 1

Adaptive and Auto-Immunity I
Studies of adaptive immune responses involving T and B lymphocytes, dendritic cells, other antigen presenting cells, and antigen
processing and presentation; Basic and pre-clinical experimental studies focused on autoimmunity.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr Yoshihide Asano, Dr. Jaehyuk Choi, Dr. Killian Eyerich

14:05-14:15

ORAL 016 [POSTER 001]

Newly identification of a CXCR6+ pathogenic skin-resident CD4+
T cell subset in a mouse model of allergic dermatitis that requires
CXCL16 for its maintenance
R. Asahina, F. Minami, G. Egawa, S. Nakamizo, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of
Medicine, Kyoto, Japan

Staphylococcus aureus skin colonization promotes SLE-likeautoimmune inflammation via neutrophil activation and the IL-23/
IL-17 axis
H. Terui1, K. Yamasaki1, M. Wada-Irimada1, M. Onodera-Amagai1,
N. Hatchome1, M. Mizuashi1, R. Yamashita2, T. Kawabe3, N. Ishii3,
T. Abe4, 5, 6, Y. Asano1, S. Aiba1
1
Department of Dermatology, Tohoku Daigaku Daigakuin Igakukei
Kenkyuka Igakubu, Sendai, Miyagi, Japan, 2Division of Translational
Informatics, Kokuritsu Gan Kenkyu Center Sentan Iryo Kaihatsu Center
Kashiwa Campus, Kashiwa, Chiba, Japan, 3Department of Microbiology
and Immunology, Tohoku Daigaku Daigakuin Igakukei Kenkyuka
Igakubu, Sendai, Miyagi, Japan, 4Division of Nephrology, Endocrinology,
and Vascular Medicine, Tohoku Daigaku Daigakuin Igakukei Kenkyuka
Igakubu, Sendai, Miyagi, Japan, 5Division of Medical Science, Tohoku
Daigaku Daigakuin Ikogaku Kenkyuka, Sendai, Miyagi, Japan,
6
Department of Clinical Biology and Hormonal Regulation, Tohoku
Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Sendai, Miyagi, Japan

13:35-13:45

14:15-14:25

13:15 -13:25

ORAL 011 [POSTER 120]

Identification of post-translationally modified trichohyalin epitopes
responsible for triggering autoimmunity in alopecia areata
S. D. Jadeja, D. Tobin
Charles Institute of Dermatology, University College Dublin, Dublin,
Ireland

13:25-13:35

ORAL 012 [POSTER 074]

ORAL 013 [POSTER 028]

Psychological stress exacerbates IgE-dependent chronic allergic
inflammation by suppressing efferocytosis of M2 macrophages
H. Urakami1, Y. Fujita2, K. Nagao2, K. Miyake4, H. Karasuyama4,
S. Miyake3, A. Kamiya2, S. Yoshikawa3, S. Morizane1
1
Department of Dermatology, Okayama Daigaku Daigakuin Ishiyakugaku
Sogo Kenkyuka, Okayama, Okayama, Japan, 2Department of Cellular
Physiology, Okayama Daigaku Daigakuin Ishiyakugaku Sogo Kenkyuka,
Okayama, Okayama, Japan, 3Department of Immunology, Juntendo
Daigaku Igakubu Daigakuin Igaku Kenkyuka, Bunkyo-ku, Tokyo, Japan,
4
Inflammation, infection and Immunity Laboratory, Advanced ResearchInstitute, Tokyo Ika Shika Daigaku, Bunkyo-ku, Tokyo, Japan

13:45-13:55

ORAL 014 [POSTER 227]

Immune response and allergenic components of COVID-19 vaccines
induced delayed cutaneous reactions
C. Tsai, W. Chung, C. Chen
Drug Hypersensitivity Clinical and Research Center, Department of
Dermatology,, Chang Gung Memorial Hospital, Linkou, Taipei, Tuchengand Keelung, Taiwan, Taoyuan, Taiwan

13:55-14:05

ORAL 015 [POSTER 126]

Topical corticosteroids inhibit allergic skin inflammation but are
ineffective in impeding the formation and expansion of resident
memory T cells
E. Ono1, V. Lenief1, M. Lefevre1, R. Cuzin1, A. Guironnet-Paquet1,
A. Mosnier1, A. Nosbaum1, 2, J. Nicolas1, 2, M. Vocanson1
1
Centre International de Recherche en Infectiologie, Lyon, Rhône-Alpes,
France, 2Hospices Civils de Lyon, Lyon, Auvergne-Rhône-Alpes , France

42

ORAL 017 [POSTER 140]

Comparative scRNA-Seq profiling of four autoimmune skin diseases
points to CXCL13 as a potential player in skin autoimmunity
Y. Wang, K. Afshari, M. Frisoli, N. Haddadi, S. Sherman, J. E. Harris,
M. Rashighi, M. Garber
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States

14:25-14:35

ORAL 018 [POSTER 133]

UVB-induced type-I interferon in keratinocytes is associatedwith expansion of CXCL13+ skin-resident memory T cells indermatomyositis skin
K. Afshari1, Y. Wang1, N. Haddadi1, S. Sherman1, J. Richmond1,
R. Vleugels2, M. Garber1, M. Rashighi1
1
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States, 2Harvard Medical School, Boston,
Massachusetts, United States

14:35-14:45

ORAL 019 [POSTER 054]

LPCAT1 aggravates hyperproliferation and inflammatory signals in
psoriasis
Y. Huang1, Y. Wang2, Y. Wang3, Y. Zhen1, Q. Sun1
1
Department of Dermatology, Qilu Hospital of Shandong University,
Jinan, Shandong, China, 2Department of Dermatology, Xi’an Jiaotong
University, Xi’an, Shaanxi, China, 3School of Life Science and Technology,
Xi’an Jiaotong University, Xi’an, Shaanxi, China

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Continued on next page.

Concurrent Mini-Symposium 1 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:45-14:55

ORAL 020 [POSTER 147]

Sebaceous glands actively contribute to distinct immune response
patterns in atopic dermatitis and psoriasis
P. Seiringer7, 4, 1, C. Hillig2, T. Biedermann7, C. C. Zouboulis6,
M. Menden2, K. Eyerich3, 1, D. Töröcsik5
1
Division of Dermatology and Venerology, Department of Medicine Solnaand Center for Molecular Medicine, Karolinska Institutet, Stockholm,
Sweden, 2Institute of Computational Biology, Helmholtz Zentrum
München, Neuherberg, Germany, 3Albert-Ludwigs-Universitat Freiburg,
Freiburg, Germany, 4Zentrum Allergie und Umwelt, Munich, Germany,
5
Department of Dermatology, Faculty of Medicine, Debreceni Egyetem,
Debrecen, Hungary, 6Medizinische Hochschule Brandenburg Theodor
Fontane, Neuruppin, Germany, 7Klinikum rechts der Isar, Department of
Dermatology and Allergy, Technische Universitat Munchen, Munchen,
Germany

14:55-15:05

ORAL 021 [POSTER 076]

TRPM2-dependent autophagy inhibition promotes CXCL16 secretionby keratinocytes under oxidative stress
P. Kang, Y. Wang, J. Chen, S. Li, X. Yi, C. Li
Department of Dermatology, Xijing Hospital, Air Force Medical University,
Xi’an, Shaanxi, China

15:05-15:15

15:25-15:35

ORAL 024 [POSTER 012]

CD4+ T cells control immune evasive tumors by reprogramming
myeloid cells in an IFN-dependent manner
A. Buzzai1, B. Kruse1, N. Shridhar1, A. Braun1, S. Gellert1, K. Knauth1,
J. Peters1, M. Mengoni1, T. van der Sluis1, A. Krone1, D. Yu2, S. Höhn1,
Y. Fu1, M. Essand2, R. Geffers3, D. Mougiakakos1, S. Kahlfuß1, H.
Kashkar4, E. Gaffal1, W. Kastenmüller5, A. Müller1, T. Tüting1
1
Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultat,
Magdeburg, Germany, 2Uppsala Universitet, Uppsala, Sweden,
3
Helmholtz-Zentrum fur Infektionsforschung GmbH, Braunschweig,
Niedersachsen, Germany, 4Institute of Molecular Immunology, Köln,
Germany, 5Institute for Systems Immunology, Würzburg, Germany

15:35-15:45

ORAL 025 [POSTER 154]

Nociceptor sensory neurons promote CD8 T cell response to VACV
infection
J. Zhang1, T. Pan1, A. Kley1, J. B. Williams1, L. Deng2, I. Chiu2,
T. S. Kupper1
1
Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts,
United States, 2Immunology, Harvard Medical School, Boston,
Massachusetts, United States

ORAL 022 [POSTER 172]

Spatiotemporal architecting of skin dendritic cell directed immunity
and tolerance
Q. Huang1, A. S. Doane2, Y. Liu2, J. Valencia5, C. Nirschl6, J. Hsu2,
A. Savitz1, K. Pradhan1, A. Jaiswal2, G. Song-Zhao6, M. Bale2,
R. R. Ricardo-Gonzalez4, R. Locksley4, T. Lawrence7, H. Young5,
M. Suarez-Farinas3, O. Elemento2, N. Anandasabapathy1
1
Department of Dermatology, Weill Cornell Medicine, New York, New
York, United States, 2Weill Cornell Medicine, New York, New York, UnitedStates, 3Icahn School of Medicine at Mount Sinai, New York, New York,
United States, 4University of California San Francisco, San Francisco,California, United States, 5National Cancer Institute, Bethesda, Maryland,
United States, 6Harvard Medical School, Boston, Massachusetts, UnitedStates, 7King’s College London, London, United Kingdom

15:15-15:25

ORAL 023 [POSTER 008]

Characterization and pharmacological inhibition of an adult antibodytransfer mouse model of pemphigus vulgaris
S. Emtenani1, M. Hofrichter1, L. Komorowski2, C. Probst2, S. Patzelt1,
E. Schmidt1, 3
1
Lübeck Institute of Experimental Dermatology, University of Lübeck,Lübeck, Germany, 2Institute of Experimental Immunology, EUROIMMUN
AG, Lübeck, Germany, 3Department of Dermatology, University of
Lübeck, Lübeck, Germany

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

43

Concurrent Mini-Symposium 2

Artificial Intelligence (AI) and Image Analysis/Translational Studies
Use of artificial intelligence and machine learning in healthcare; Technologies used for medical imaging and diagnostics/Studies
that translate basic research findings into human model systems (i.e. human tissue and/or cells) or humans.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Takashi Okamoto, Dr. Shawn Kwatra, Dr. Thomas Tüting
13:15-13:25

ORAL 026 [POSTER 217]

Time-to-event machine learning prediction of metastatic recurrenceof localized melanoma
G. Wan1, 5, B. Leung1, M. DeSimone2, N. Nguyen1, A. Rajeh1, M. Collier1,
H. Rashdan1, K. Roster1, M. Asgari1, 5, A. Gusev3, A. Stagner1, C. Lian2,
M. Hurlbert4, K. Yu5, H. Tsao1, 5, F. Liu6, P. Sorger5, Y. Semenov1, 51
Massachusetts General Hospital, Boston, Massachusetts, UnitedStates, 2Brigham and Women’s Hospital, Boston, Massachusetts, UnitedStates, 3Dana-Farber Cancer Institute, Boston, Massachusetts, UnitedStates, 4Melanoma Research Alliance, Washington, District of Columbia,
United States, 5Harvard Medical School, Boston, Massachusetts, UnitedStates, 6Stevens Institute of Technology, Hoboken, New Jersey, UnitedStates13:25-13:35

13:55-14:05

ORAL 030 [POSTER 207]

Comparison of neural network classification models to determine
patch test reactivity
A. Ravishankar, P. L. Bigliardi
Dermatology, University of Minnesota Twin Cities, Minneapolis,
Minnesota, United States

14:05-14:15

ORAL 031 [POSTER 210]

A novel system with an end-to-end framework for mouse scratchingdetection based on deep learning techniquesJ. P. Peng1, B. Hsu2, Y. Lin2, V. S. Tseng2, C. Lee3
1
Chang Gung Memorial Hospital Kaohsiung Branch Department ofInternal Medicine, Kaohsiung, Taiwan, 2National Yang Ming Chiao
Tung University Department of Computer Science, Hsinchu, Taiwan,
3
Department of Dermatology, Chang Gung Memorial Hospital KaohsiungBranch, Kaohsiung, Taiwan

ORAL 027 [POSTER 202]

Automated assessment of tumor infiltrating lymphocytes informs
mortality in thin melanoma
S. X. Tan1, T. Nwe Aung2, M. Claeson3, C. Zhou1, S. Brown1, B. Acs2,
D. Lambie6, P. Baade4, N. Pandeya5, H. Soyer1, B. Smithers6,
D. Whiteman5, D. Rimm2, K. Khosrotehrani1
1
The University of Queensland, Saint Lucia, Queensland, Australia,
2
Yale University, New Haven, Connecticut, United States, 3Sahlgrenska
Academy, Gothenburg, Sweden, 4Cancer Council Queensland, Spring
Hill, Queensland, Australia, 5QIMR Berghofer Medical ResearchInstitute, Herston, Queensland, Australia, 6Princess Alexandra Hospital,
Woolloongabba, Queensland, Australia

14:15-14:25

14:25-14:35
13:35-13:45

ORAL 028 [POSTER 203]

Automated skin surface phenotype for melanoma risk assessment
B. D. Betz-Stablein1, C. Rutjes1, S. Kahler1, A. Mothershaw1,
D. Jayasinghe2, M. Stark1, M. Janda2, H. Soyer1
1
Dermatology Research Centre, The University of Queensland, Brisbane,
Queensland, Australia, 2Centre for Health Services Research, The
University of Queensland, Brisbane, Queensland, Australia

13:45-13:55

ORAL 032 [POSTER 214]

Transforming wound assessment and management with artificial
intelligence
P. Bishnoi1, Y. Ng1, O. E. Ping2, R. Srivastava2, T. K. Kyar2, D. Y. Tan3,
Z. Jingxian3, H. Susainathan3, R. Q. So2
1
Skin Research Institute of Singapore, A*STAR, Singapore, Singapore,
2
Institute for Infocomm Research, Singapore, Singapore, 3Diagnostics
Development Hub, Singapore, Singapore

ORAL 033 [POSTER 1572]

HLA I shields tumor lymphocytes from NK-cell-mediated eliminationin the skin
Y. Chang1, S. Kimeswenger2, M. Bobrowicz4, S. Pascolo3,
W. Hoetzenecker2, E. Guenova1
1
Dermatology, Centre Hospitalier Universitaire Vaudois, Lausanne, Vaud,
Switzerland, 2Dermatology, Johannes Kepler Universitat Linz, Linz,
Austria, 3Dermatology, UniversitatsSpital Zurich, Zurich, Switzerland,
4
Immunology, Warszawski Uniwersytet Medyczny, Warszawa,
Mazowieckie, Poland

ORAL 029 [POSTER 212]

Teledermatology photographs deblurring by deep learning models
restores the accuracy of blurry images classification
Z. Jiang3, H. Yeh1, B. Hsu2, S. Chou2, T. Hsu3, V. S. Tseng2, C. Lee3, 41Chen Chia-Wei Dermatology, Kaohsiung, Taiwan, 2Computer
Science, National Yang Ming Chiao Tung University, Hsinchu, Taiwan,
3
Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch,
Kaohsiung, Taiwan, 4Chang Gung University College of Medicine,
Taoyuan, Taiwan

14:35-14:45

ORAL 034 [POSTER 1625]

Novel mechanism of cell proliferation in cutaneous T cell lymphoma
X. Zhang, H. Li, C. Chen, J. Hsiang, S. Nam, W. Hu, X. Wu, D. Horne,
J. Shively, S. Rosen
City of Hope, Duarte, California, United States

Continued on next page.

44

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 2 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:45-14:55

ORAL 035 [POSTER 1545]

Circulating tumor DNA reflects tumor burden and detects earlyrecurrence in patients with Merkel cell carcinoma
T. Akaike1, D. S. Hippe2, N. So3, N. Maloney3, L. Gunnell1, E. Hall1,
A. Rodriguez4, A. Aleshin4, P. Nghiem1, L. Zaba3
1
University of Washington, Seattle, Washington, United States, 2Fred
Hutchinson Cancer Research Center, Seattle, Washington, United States,
3
Stanford University School of Medicine, Stanford, California, UnitedStates, 4Natera, Inc, Austin, Texas, United States

14:55-15:05

ORAL 036 [POSTER 1556]

CSL324, a G-CSF receptor antagonist, blocks neutrophil migration
markers that are upregulated in hidradenitis suppurativa
C. Gamell1, K. Scalzo-Inguanti1, B. Sedgmen1, M. Alhamdoosh1,
C. Millar1, L. Johnson1, A. Dyson1, J. Nicolopoulos2, G. Varigos2,
M. Ng1, N. Wilson1, J. Field1, J. S. Kern2, L. M. Lindqvist1
1
CSL Limited, Parkville, Victoria, Australia, 2The Royal Melbourne
Hospital, Parkville, Victoria, Australia

15:25-15:35

15:35-15:45
15:05-15:15

ORAL 037 [POSTER 1621]

Spatial mass cytometry-based single cell imaging reveals a disrupted
epithelial-immune axis in prurigo nodularis
A. Kambala, J. R. Patel, H. Cornman, K. K. Lee, S. V. Reddy, O. O.
Oladipo, W. Ho, S. Kwatra
Department of Dermatology, Johns Hopkins University School of
Medicine, Baltimore, Maryland, United States

15:15-15:25

ORAL 039 [POSTER 1598]

Comparative proteomic analyses of microdissected nevi andmelanoma subtypes reveal functional differences
S. Naimy2, 3, D. Kuczek4, J. B. Solberg1, M. Bzorek2, T. Litman5,
A. Mund3, M. B. Lovendorf1, 5, R. Clark6, L. R. Gjerdrum2, 7, M. Mann3, 4,
B. Dyring-Andersen1, 3, 5
1
Department of Dermatology and Allergy, Herlev-Gentofte University
Hospital, Hellerup, Denmark, 2Department of Pathology, Copenhagen
University Hospital, Zealand University Hospital, Roskilde, Denmark,3
Novo Nordisk Foundation Center for Protein Research, Universityof Copenhagen, Copenhagen, Denmark, 4Max-Planck-Institute of
Biochemistry, Munich, Martinsried, Germany, 5Leo Foundation Skin
immunology Research Center, Department of Immunology andMicrobiology, University of Copenhagen, Copenhagen, Denmark,6
Department of Dermatology, Brigham’s and Women’s Hospital, Harvard
Medical School, Boston, Massachusetts, United States, 7Department ofClinical Medicine, University of Copenhagen, Copenhagen, Denmark

ORAL 040 [POSTER 1566]

Fate induction through asymmetric T cell division is modulated bychimeric antigen receptor co-stimulatory domains
C. Berry1, C. Lee1, A. R. Kelly2, S. Oh1, R. O’Connor2, C. Ellebrecht1
1
Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania,
United States, 2Department of Pathology and Laboratory Medicine,
University of Pennsylvania, Philadelphia, Pennsylvania, United States

ORAL 038 [POSTER 1607]

Multiomic analysis of immune-related adverse events (irAEs) inmelanoma patients treated with anti-PD1-based immune checkpoint
inhibitors (ICIs)
F. Dimitriou1, P. Cheng1, A. Saltari1, R. Staeger1, A. Tastanova1,
M. Levesque1, G. Long3, B. Becher2, R. Dummer1
1
Dermatology Department, UniversitatsSpital Zurich, Zurich, Switzerland,
2
Immunology Department, Universitat Zurich, Zurich, Switzerland,
3
Melanoma Institute Australia, North Sydney, New South Wales, Australia

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

45

Concurrent Mini-Symposium 3

Carcinogenesis and Cancer Genetics
Studies on the genetics and other causes of cancer as well as mechanisms relevant to metastasis––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Kiarash Khosrotehrani, Dr. Kavita Sarin, Dr. Remco van Doorn
13:15-13:25

ORAL 041 [POSTER 264]

Genetic ablation of host p38δ promotes antitumor immunity andreduces tumor growth
A. Kiss1, J. Chen1, F. Cheng1, C. Wei1, N. Adusumilli1, S. Sandhu1,
S. Simmens1, E. Sotomayor3, T. Efimova2, 1
1
The George Washington University, Washington, District of Columbia,
United States, 2Northwestern University, Evanston, Illinois, United States,
3
Tampa General Hospital, Tampa, Florida, United States

13:25-13:35

ORAL 042 [POSTER 277]

HPV8 E6 induced STAT3 activation leads to hair follicle junctionalzone keratinocyte stem cell proliferation and expansion in actinic
keratoses
C. Olivero1, H. Morgan1, L. Martuscelli2, A. Gibbs1, B. Shorning1,
C. Borgogna2, M. De Andrea2, M. Hufbauer3, S. Smola4, H. Pfister3,
B. Akgul3, M. Gariglio2, G. Patel1
1
European Cancer Stem Cell Research Institute, Cardiff University,
Cardiff, United Kingdom, 2Translational Medicine, University of PiemonteOrientale, Novara, Italy, 3Virology, Universitat zu Koln, Koln, NordrheinWestfalen, Germany, 4Virology, Saarland University Medical Center,
Homburg, Germany

13:35-13:45

ORAL 043 [POSTER 297]

Expanded genomic landscape of merkel cell carcinoma identifies new
drivers
Y. Zhang1, Z. Reinstein1, K. Qiu1, J. Jackson1, M. Nichols2, H. Liu1,
K. Tsai2, J. Choi11
Department of Dermatology, Northwestern University Feinberg Schoolof Medicine, Chicago, Illinois, United States, 2Department of Pathology,
Moffitt Cancer Center, Tampa, Florida, United States

13:45-13:55

ORAL 044 [POSTER 267]

Establishment of a new immunocompetent mouse model of merkel
cell carcinoma
K. M. Prieto-Sarmiento1, A. de Mingo Pulido1, B. R. Sell1, O. Chavez
Chiang1, P. W. Harms2, M. E. Verhaegen2, A. Dlugosz2, T. Patel3,
C. Coarfa3, K. Tsai1
1
Clinical Science, Moffitt Cancer Center, Tampa, Florida, United States,2
Dermatology, University of Michigan, Ann Arbor, Michigan, UnitedStates, 3Baylor College of Medicine, Houston, Texas, United States

13:55-14:05

ORAL 045 [POSTER 311]

Single-cell transcriptomics reveals distinct molecular programs infolliculotropic mycosis fungoides
T. Qin1, A. Billi2, J. Runge2, R. Wasikowski2, Q. Li2, Y. Wang3, M. Sartor2,
P. W. Harms2, J. Gudjonsson2, A. Hristov2, L. C. Tsoi2, T. Tejasvi1,2
1Computational Medicine and Bioinformatics, University of Michigan,
Ann Arbor, Michigan, United States, 2University of Michigan, Ann Arbor,
Michigan, United States, 3Peking University, Beijing, China

14:05-14:15

ORAL 046 [POSTER 303]

Single-cell RNA sequencing of erythrodermic CTCL compared to
atopic dermatitis and unspecific chronic erythroderma definesdisease-specific markers
K. Rindler1, S. Chennareddy2, M. Medjimorec1, L. Shaw1, U. Mann1,
W. Weninger1, M. Farlik1, C. Jonak1, P. Brunner2
1
Department of Dermatology, Medizinische Universitat Wien, Wien,
Wien, Austria, 2Department of Dermatology, Icahn School of Medicine atMount Sinai, New York, New York, United States

14:15-14:25

ORAL 047 [POSTER 253]

PRMT1 inhibition as a novel therapeutic approach in squamous cell
carcinoma
R. Boudra1, B. Patenall1, S. King1, S. Xu2, D. Wang2, M. Padilla1,
C. Schmults1, S. Barthel1, C. Lian2, M. R. Ramsey1
1
Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts,
United States, 2Pathology, Brigham and Women’s Hospital, Boston,
Massachusetts, United States

14:25-14:35

ORAL 048 [POSTER 244]

The sphingosine-1-phosphate-cathelicidin axis has a pivotal role inthe development of cutaneous squamous cell carcinoma
K. Park1, 2, 3, Y. Kim2, 3, K. Shin1, 4, Y. Bae1, Y. Choi1, A. Nielsen-Scott2, 3,
C. Mainzer2, 3, A. Celli2, 3, W. Holleran2, 3, S. Arron2, 3, T. Mauro2, 3,
P. Elias2, 3, Y. Uchida1, 2, 3
1
Food Science and Nutrition, Hallym University, Chuncheon,
Gangwon-do, Korea (the Republic of), 2Dermatology, University ofCalifornia San Francisco, San Francisco, California, United States,
3
Northern California Institute for Research and Education, San Francisco,California, United States, 4LaSS Inc., Chunche, Korea (the Republic of)

14:35-14:45

ORAL 049 [POSTER 258]

Ire1α nmsc mutations enhance keratinocyte uv response and survival
through rac1 activation
S. Mogre, J. Son, A. GlickThe Pennsylvania State University, University Park, Pennsylvania, UnitedStatesContinued on next page.

46

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 3 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:45-14:55

ORAL 050 [POSTER 250]

A specific neurotrophin network characterizes cSCC subpopulations
and correlates with their behavior by patient-derived spheroids andzebrafish avatar
M. Quadri1, L. Reggiani Bonetti2, R. Panini2, N. Tiso3, R. Lotti1, C.
Pincelli1, A. Marconi1, E. Palazzo1
1
CHIMOMO, Unimore, Modena, Italy, 2Dept of Pathology, Unimore,
Modena, Italy, 3Dept of Biology, UniPD, Padua, Italy
14:55-15:05

ORAL 051 [POSTER 275]

Spatial transcriptomics of early invasive melanomas reveals
molecular determinants of patient survival
C. Zhou1, S. X. Tan1, Y. Kao1, M. Claeson5, S. Brown1, D. Lambie3,
D. Whiteman2, H. Soyer1, M. Stark1, Q. Nguyen4, K. Khosrotehrani1
1
The University of Queensland Frazer Institute, Brisbane, Queensland,
Australia, 2QIMR Berghofer Medical Research Institute, Herston,
Queensland, Australia, 3Pathology Queensland, Princess Alexandra
Hospital, Brisbane, Queensland, Australia, 4The University of Queensland
Institute for Molecular Bioscience, Saint Lucia, Queensland, Australia,
5Institute of Clinical Sciences, Sahlgrenska Academy, University ofGothenburg, Gothenburg, Sweden

15:05-15:15

15:35-15:45

ORAL 055 [POSTER 316]

EPHB2 germline mutation in patients with high frequency basal cell
carcinomas and prostate carcinoma
A. Chiang1, G. Swaminathan1, M. Harris1, V. Hua1, W. Chan1, J. Ramos1,
K. Yekrang1, H. Do1, I. Bailey1, K. E. Rieger1, 2, C. Curtis3, 4, J. Y. Tang1,
A. Oro1, K. Sarin1
1
Dermatology, Stanford University School of Medicine, Stanford,
California, United States, 2Dermatopathology, Stanford University Schoolof Medicine, Stanford, California, United States, 3Medicine (Oncology),
Stanford University School of Medicine, Stanford, California, UnitedStates, 4Genetics, Stanford University School of Medicine, Stanford,
California, United States

ORAL 052 [POSTER 289]

Crosstalk between MET-dependent receptor tyrosine kinase signaling
and oncogenic Gαq mutations in melanoma
B. Andreas1, M. Mengoni1, S. Seedarala1, S. Bonifatius1, E. Kostenis2,
T. Tüting1, E. Gaffal1
1
Dermatology, University Hospital Magdeburg, Magdeburg, Germany,
2
University of Bonn, Bonn, Germany

15:15-15:25

ORAL 053 [POSTER 233]

Epigenetic age dysregulation is associated with clinical features of
cutaneous melanoma and melanocytic nevi
R. Jeremian1, 2, J. R. Georgakopoulos3, 4, J. Yeung4, 3, I. Litvinov2, 1
1
McGill University Faculty of Medicine and Health Sciences, Montreal,
Quebec, Canada, 2McGill University Health Centre, Montreal, Quebec,
Canada, 3University of Toronto Temerty Faculty of Medicine, Toronto,
Ontario, Canada, 4Sunnybrook Health Sciences Centre, Toronto, Ontario,
Canada15:25-15:35

ORAL 054 [POSTER 305]

Matrix metalloproteinase-1 expression in fibroblasts accelerates
dermal aging and promotes tumor development in mouse skin
G. J. Fisher1, W. Xia1, T. He1, G. Bou-Gharios2, J. J. Voorhees1,
A. Dlugosz1, T. Quan1
1
Dermatology, University of Michigan, Ann Arbor, Michigan, UnitedStates, 2Matrix Biology, University of Liverpool Faculty of Health and Life
Sciences, Liverpool, United Kingdom

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

47

Concurrent Mini-Symposium 4

Clinical Research – Epidemiology and Observational Research I
Non-interventional studies of populations or patient cohorts that evaluate, but are not limited to, the natural history of disease,disease burden, co-morbidities, health-related quality of life, and patient-reported outcomes research.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Chong Hyun Won, Dr. Julie Ryan Wolf, Dr. Sara Brown

14:05-14:15

ORAL 061 [POSTER 383]

A framework to study the epidemiological and molecular basis ofpsoriasis severity, with application in UK Biobank and BSTOP
J. Saklatvala1, R. Ramessur1, M. Simpson1, S. M. Langan3, S. Brown4,
L. Paternoster2, N. Dand1, C. Smith1
1King’s College London, London, United Kingdom, 2University of Bristol,
Bristol, United Kingdom, 3London School of Hygiene & Tropical Medicine,
London, United Kingdom, 4University of Edinburgh, Edinburgh, United
Kingdom

Non-invasively collected RNA in sebum reflects the characteristics
and severity of atopic dermatitis
A. Tanaka1, T. Nakahara2, K. Masuda3, N. Takada4, T. Kuwano4,
T. Inoue4, S. Hoashi5, Y. Kawasaki5, H. Saeki6
1
Department of Dermatology, Hiroshima Daigaku, Hiroshima, Hiroshima,
Japan, 2Department of Dermatology, Kyushu Daigaku, Fukuoka, Fukuoka,
Japan, 3Department of Dermatology, Kyoto Furitsu Ika Daigaku, Kyoto,
Kyoto, Japan, 4Biological Science Laboratory, Kao Kabushiki Kaisha,Chuo, Tokyo, Japan, 5Diagnostics Department, Maruho Kabushiki
Kaisha, Osaka, Osaka, Japan, 6Department of Dermatology, Nihon Ika
Daigaku, Bunkyo, Tokyo, Japan

13:25-13:35

14:15-14:25

13:15-13:25

ORAL 056 [POSTER 448]

ORAL 057 [POSTER 446]

ORAL 062 [POSTER 540]

The risk of lymphoproliferative disorders and skin cancers inpatients with psoriasis and inflammatory bowel disease administeredbiologics
J. Jung, E. Choi, G. Kim, S. Chang, M. Lee, C. Won, W. Lee
Dermatology, Asan Medical Center, Songpa-gu, Seoul, Korea (theRepublic of)

A longitudinal cohort study of atopic dermatitis and epigenetic age
acceleration across childhood
M. Ye1, P. Collender2, S. M. Langan3, A. Cardenas4, K. Abuabara1, 2
1
UCSF, San Francisco, California, United States, 2UC Berkeley, Berkeley,
California, United States, 3LSHTM, London, United Kingdom, 4Stanford
University, Stanford, California, United States

13:35-13:45

14:25-14:35

ORAL 058 [POSTER 407]

A population-based cohort study of sodium consumption andpsoriasis
A. Chattopadhyay, B. Chiang, Y. Halezeroglu, K. Abuabara
University of California San Francisco, San Francisco, California, UnitedStates13:45-13:55

ORAL 063 [POSTER 558]

Higher hemoglobin A1C is associated with greater disease severity inhidradenitis suppurativa
N. Foolad1, W. Liu1, 2, J. T. Kwock1, T. Jaleel1
1
Dermatology, Duke University School of Medicine, Durham, North
Carolina, United States, 2Department of Neurobiology, Duke University
School of Medicine, Durham, North Carolina, United States

ORAL 059 [POSTER 394]

Differential associations of psoriasis subtypes with autoimmune
disorders in United States children and adults: A cross-sectional
study
Z. Ren1, J. Silverberg2
1
Department of Dermatology, Northwestern University Feinberg
School of Medicine, Chicago, Illinois, United States, 2Department of
Dermatology, The George Washington University School of Medicine
and Health Sciences, Washington, District of Columbia, United States

13:55-14:05

ORAL 060 [POSTER 552]

Transitions in blood immune profile in atopic dermatitis from infancy
to adulthood
E. Del Duca1, Y. Renert-Yuval2, A. Pavel1, D. Mikhaylov1, R. Lefferdink1,
M. Fang1, A. Sheth3, P. Facheris1, J. Wu1, Y. Estrada1, S. Rangel3,
J. Krueger2, A. Paller3, E. Guttman-Yassky1
1
Icahn School of Medicine at Mount Sinai, New York, New York, UnitedStates, 2Dermatology, The Rockefeller University, New York, New York,
United States, 3Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States

14:35-14:45

ORAL 064 [POSTER 489]

Long-term oral antibiotics for acne and antibiotic treatment failure
K. Bhate1, R. Mathur2, S. M. Langan1
1
London School of Hygiene & Tropical Medicine, London, United
Kingdom, 2Queen Mary University of London, London, United Kingdom

14:45-14:55

ORAL 065 [POSTER 470]

Regulatory T cells act either by expansion at the acute phase or bysteep contraction at the resolution phase in severe drug eruptions
Y. Mizukawa, R. Takahashi, T. Shiohara
Kyorin Daigaku, Mitaka, Tokyo, Japan

Continued on next page.

48

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 4 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:55-15:05

ORAL 066 [POSTER 562]

Merkel polyomavirus antibody testing for detecting recurrent Merkel
cell carcinoma: A prospective, real-world outcomes study
L. Gunnell1, T. Akaike1, K. Lachance1, D. S. Hippe2, K. Cahill1,
C. Doolittle-Amieva2, 1, L. Zawacki1, S. Park1, 2, P. Nghiem1, 2
1
University of Washington Department of Medicine, Seattle, Washington,
United States, 2Fred Hutchinson Cancer Research Center, Seattle,
Washington, United States

15:05-15:15

ORAL 067 [POSTER 385]

15:35-15:45

ORAL 070 [POSTER 421]

Genotype-phenotype correlation analysis in Japanese patients withpachydermoperiostosis
R. Tanaka1, H. Niizeki1, T. Nomura2, A. Seki3, S. Narumi4,
K. Nakabayashi5, K. Yoshida1
1
Dermatology, National Center for Child Health and Development, Tokyo,
Japan, 2Dermatology, Kyoto University, Kyoto, Japan, 3Orthopaedic
Surgery, National Center for Child Health and Development, Tokyo,
Japan, 4Molecular Endocrinology, National Center for Child Health andDevelopment, Tokyo, Setagaya-ku, Japan, 5Maternal-Fetal Biology,
National Center for Child Health and Development, Tokyo, Japan

Skin cancers in patients with actinic keratoses
C. Mohr1, Y. Li1, L. Navsaria1, C. Hinkston1, D. Margolis2, M. Wehner11
Health Services Research, The University of Texas MD Anderson Cancer
Center, Houston, Texas, United States, 2University of Pennsylvania
Perelman School of Medicine, Philadelphia, Pennsylvania, United States
15:15-15:25

ORAL 068 [POSTER 450]

The impact of mental health comorbidities on patient satisfaction: A
population study among U.S. adults with skin cancer
C. Read2, 1, 3, J. F. Apperley2, S. P. Hettiaratchy2, A. Armstrong1
1
Dermatology, University of Southern California, Los Angeles, California,
United States, 2Medicine, Imperial College London, London, United
Kingdom, 3Dermatology, University of Washington, Seattle, Washington,
United States

15:25-15:35

ORAL 069 [POSTER 541]

Gene set enrichment analysis identifies biological networks
associated with skin aging in a large Japanese population: Data fromthe Nagahama cohort
J. Latreille3, G. Thorn1, 2, R. Jdid3, G. Gendronneau3, Y. Tabara4,
Y. Harada5, S. Forestier3, C. Chelala1, 2, F. Matsuda4
1
Bioinformatics Unit, Barts Cancer Institute, London, United Kingdom,
2
Queen Mary University of London, London, United Kingdom, 3IRD, Chanel
SAS, PANTIN, Île-de-France, France, 4Center for Genomic Medicine, Kyoto
Daigaku Igaku Kenkyuka Fuzoku Genome Igaku Center, Kyoto, Japan,
5
Research and Technology Development Laboratory, Chanel Kabushiki
Kaisha Funabashi Corporate Operations Center, Funabashi, Chiba, Japan

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

49

Concurrent Mini-Symposium 5

Genetic Disease, Gene Regulation, and Gene Therapy
Studies on cutaneous gene expression (including genomic based studies) and genetic diseases including gene therapy––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Akiharu Kubo, Dr. Cristina de Guzman Strong, Dr. Edel O’Toole
13:15-13:25

ORAL 071 [POSTER 806]

Results from VIITAL: A phase 3, randomized, intrapatient-controlled
trial of an investigational collagen type VII gene–corrected
autologous cell therapy, EB-101, for the treatment of recessive
dystrophic epidermolysis bullosa (RDEB)
J. Y. Tang2, M. P. Marinkovich2, 3, K. Wiss4, D. McCarthy5, A. Truesdale1,
A. S. Chiou2, J. K. McIntyre4, A. Moore1, I. Grachev1
1
Abeona Therapeutics Inc, Cleveland, Ohio, United States, 2Stanford
University School of Medicine, Stanford, California, United States, 3VA
Palo Alto Health Care System, Palo Alto, California, United States,
4
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States, 5Abeona Therapeutics Inc, Cleveland,Ohio, United States

13:25-13:35

13:55-14:05

ORAL 075 [POSTER 875]

ELX-02 suppress premature stop mutations and restores type VII
collagen and laminin 332 function in RDEB and JEB
Y. Hou1, X. Tang1, L. Bainvoll1, S. Aghamohammadzadeh2, M. Chen1
1
Dermatology, University of Southern California, Los Angeles, California,
United States, 2Eloxx Pharmaceuticals, Watertown, Massachusetts,
United States

14:05-14:15

ORAL 076 [POSTER 861]

CTSZ pathogenic variants affect EGFR expression and cause
autosomal dominant palmoplantar keratoderma
K. Malovitski1, 2, O. Sarig1, Y. Feller1, 2, S. Bergson1, 2, S. Assaf1, 2,
J. Mohamad1, 2, M. Pavlovsky1, M. Giladi2, 3, E. Sprecher1, 2
1
Division of Dermatology, Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel
Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel, 3Department
of Internal Medicine D, Tel Aviv Medical Center, Tel Aviv, Israel

ORAL 072 [POSTER 853]

HMCN1 variants aggravate epidermolysis bullosa phenotype
S. Bergson1, 2, O. Sarig1, A. Nitzan2, S. Hainzl3, T. Kocher3, M. Giladi1,
2, J. Illmer3, J. Mohamad1, 2, E. Geller1, 2, K. Malovitski1, 2, Y. Feller1, 2,
N. Eretz Kdosha1, R. Zauner3, J. Pinon Hofbauer3, R. ShalomFeuerstein4, V. Wally3, U. Koller3, R. Zaidel-Bar2, L. Samuelov1, 2, E.
Sprecher1, 2
1
Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel Aviv University, Tel Aviv,
Israel, 3Paracelsus Medical University, EB House Austria, Salzburg,
Austria, 4Technion Israel Institute of Technology, Haifa, Israel

Alternative mRNA splicing regulates epidermal differentiation
S. Takashima1, 3, W. Sun2, A. Otten1, P. Cai2, J. Bui1, M. Mai1,
O. Amarbayar1, B. Cheng1, E. Tong1, Z. Li2, K. Qu2, B. Sun1
1
Department of Dermatology, University of California San Diego, La Jolla,
California, United States, 2Division of Molecular Medicine, University of
Science and Technology of China, Hefei, Anhui, China, 3Departmentof Dermatology, Hokkaido University Graduate School of Medicine,
Sapporo, Hokkaido, Japan

13:35-13:45

14:25-14:35

ORAL 073 [POSTER 849]

14:15-14:25

ORAL 077 [POSTER 807]

ORAL 078 [POSTER 812]

Twin prime editing for restoring type VII collagen expression inprimary recessive dystrophic epidermolysis patient cells
M. Osborn, B. Steinbeck, A. N. McElroy, J. Tolar
Pediatrics, University of Minnesota Twin Cities, Minneapolis, Minnesota,
United States

Regulation of keratinocyte proliferation and differentiation by
nucleoporins through nucleocytoplasmic trafficking and direct
chromatin binding
X. Bao, A. Neely, Y. Zhang, H. Zhang
Northwestern University, Evanston, Illinois, United States

13:45-13:55

14:35-14:45

ORAL 074 [POSTER 884]

Reproducible correction of COL7A1 nonsense variants with ABE8e
adenine base editor
J. K. Jackow1, A. Sheriff1, I. Guri1, I. Brooks1, M. Dimitrievska1,
G. Newby2, D. Liu2, L. Laczmanski3, J. A. McGrath1
1
St John’s Institute of Dermatology, King’s College London, London,
United Kingdom, 2Merkin Institute of Transformative Technologies
in Healthcare, Broad Institute of Harvard and MIT, Cambridge,
Massachusetts, United States, 3Institute of Immunology andExperimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

ORAL 079 [POSTER 864]

Homologous recombination is prevalent in normal keratinocytes
in vivo in mice
G. Egawa, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of
Medicine, Kyoto, Japan

Continued on next page.

50

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 5 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:45-14:55

ORAL 080 [POSTER 840]

Excess klhl24 impairs skin wound healing by degradation of vimentin
Y. Liu1, J. Cui2, J. Zhang2, Z. Chen1, Z. Song1, D. Bao1, R. Xiang1, D. Li1,
Y. Yang1
1
Affiliated Hospital for Skin Diseases of Chinese Academy of Medical
Sciences, Nanjing, Jiangsu, China, 2Peking University First Hospital,
Beijing, China

14:55-15:05

ORAL 081 [POSTER 860]

Fragile WWOX gene maintains genome integrity in fibroblasts
H. Cheng2, Y. Chou3, C. Hsu2, L. Hsu1
1
Department of Medical Laboratory Science and Biotechnology, National
Cheng Kung University College of Medicine, Tainan, Taiwan, 2Departmentof Dermatology, National Cheng Kung University College of Medicine,
Tainan, Taiwan, 3Institute of Basic Medical Sciences, National Cheng
Kung University College of Medicine, Tainan, Taiwan

15:05-15:15

15:35-15:45

ORAL 085 [POSTER 841]

A vitiligo-associated SNP (rs706779) controls IL15RA isoforms andT cell activation in epidermal keratinocytes
K. Okamura1, 2, S. Shan3, Q. Tang1, 4, P. Vangala3, X. Fan1, C. Salomão
Lopes3, Y. Cao3, W. Ko3, T. Suzuki2, A. Khvorova4, M. Garber3,
J. E. Harris1
1
Department of Dermatology, University of Massachusetts Chan
Medical School, Worcester, Massachusetts, United States, 2Departmentof Dermatology, Faculty of Medicine, Yamagata University, Yamagata,Japan, 3Department of Bioinformatics and Computational Biology,
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States, 4RNA Therapeutics Institute, University of
Massachusetts Chan Medical School, Worcester, Massachusetts, UnitedStatesORAL 082 [POSTER 882]

Enhancer RNA (eRNA) profiling to understand transcription regulationin keratinocytes
M. T. Patrick, M. Sarkar, Z. Zhang, H. Zhang, J. T. Elder, J. Gudjonsson,
L. C. Tsoi
University of Michigan, Ann Arbor, Michigan, United States

15:15-15:25

ORAL 083 [POSTER 877]

Loss of UBE2N in keratinocytes leads to skin inflammation andimmune infiltration through IRAK1/4-mediated processes
M. Lee1, 2, M. Ben Hammouda1, W. Miao1, Y. J. Jin1, Y. Huang1, H. Sun1,
V. Markovtsov3, J. Y. Zhang1
1
Dermatology, Duke University School of Medicine, Durham, North
Carolina, United States, 2Molecular Genetics and Microbiology, Duke
University School of Medicine, Durham, North Carolina, United States,
3
Rigel Pharmaceuticals Inc, South San Francisco, California, UnitedStates

15:25-15:35

ORAL 084 [POSTER 808]

Seizures in Sturge-Weber syndrome are associated with disrupted
calcium metabolism
D. Zecchin1, 2, N. Knoepfel1, 2, 3, A. K. Gluck4, M. Stevenson4,
H. Richardson3, S. Polubothu2, 3, A. Inoue5, K. Lines4, A. Chesover3,
T. Jacques3, 2, F. Hannan4, U. Loebel3, R. Semple6, R. V. Thakker4,
V. A. Kinsler1, 2, 3
1
The Francis Crick Institute, London, London, United Kingdom, 2University
College London, London, London, United Kingdom, 3Great Ormond Street
Hospital for Children NHS Foundation Trust, London, London, United
Kingdom, 4University of Oxford, Oxford, Oxfordshire, United Kingdom,
5
Tohoku Daigaku, Sendai, Miyagi, Japan, 6University of Edinburgh,
Edinburgh, United Kingdom

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

51

Concurrent Mini-Symposium 6

Tissue Regeneration and Wound Healing
Wound healing and regeneration studies; processes/signaling that regulate vascular development and angiogenesis; interactions
between different skin components that contribute to the functional process of wound healing or tissue regeneration.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Sung-Jan Lin, Dr. Xiomin Bao, Dr. Kaisa Tasanen

14:05-14:15

ORAL 091 [POSTER 1518]

Combined transcriptome and epigenome profiling reveal regulatorsof dermal fibroblast state switch
T. Kirk, A. Ahmed, J. Connelly, E. Rognoni
Queen Mary University of London, London, United Kingdom

Identification of gene products from staphylococcus aureus that
inhibit keratinocyte migration and wound repair
M. D. Bagood1, A. Horswill2, R. L. Gallo1
1
Dermatology, University of California San Diego, La Jolla, California,
United States, 2Immunology & Microbiology, University of Colorado
Anschutz Medical Campus School of Medicine, Aurora, Colorado, UnitedStates13:25-13:35

14:15-14:25

13:15-13:25

ORAL 086 [POSTER 1512]

ORAL 087 [POSTER 1448]

Ligand-dependent Wnt signaling attenuates mechanotransduction
and protects against wound occlusion-mediated abolishment of hairfollicle regeneration
A. S. Oak, Y. Zheng, A. Nace, R. Yang, A. Ray, G. Cotsarelis
Department of Dermatology, University of Pennsylvania Perelman
School of Medicine, Philadelphia, Pennsylvania, United States

14:25-14:35
13:35-13:45

ORAL 088 [POSTER 1478]

TEM1/endosialin/CD248 promotes pathologic scarring by augmenting
TGF-β activity through its receptor stability in dermal fibroblasts
Y. Hong1, 2, 4, Y. Lin1, 2, Y. Chang1, Y. Huang1, J. A. McGrath1, 6,
H. Wu2, 3, 4, C. Hsu1, 2, 5
1
Department of Dermatology, National Cheng Kung University, Tainan,
Taiwan, 2International Center for Wound Repair and Regeneration(iWRR), National Cheng Kung University, Tainan, Taiwan, 3Departmentof Biochemistry and Molecular Biology, National Cheng Kung University,
Tainan, Taiwan, 4The Institute of Basic Medical Sciences, National
Cheng Kung University, Tainan, Taiwan, 5Institute of Clinical Medicine,National Cheng Kung University, Tainan, Taiwan, 6St John’s Institute of
Dermatology, School of Basic and Medical Biosciences, King’s College
London, London, London, United Kingdom

ORAL 089 [POSTER 1475]

Single cell RNA-seq reveals cell-type specific circadian regulationsin the mouse dermis
J. Duan1, M. Ngo1, S. Karri2, J. Lowengrub1, B. Shahbaba1,
B. Andersen2
1
Center for Complex Biological Systems, University of California Irvine,
Irvine, California, United States, 2Department of Biological Chemistry,
University of California Irvine, Irvine, California, United States

13:55-14:05

ORAL 090 [POSTER 1480]

CXCR4 expression by regulatory T cells promotes cutaneous tissue
regeneration
J. Cohen, M. Rosenblum
Dermatology, University of California San Francisco, San Francisco,California, United States

ORAL 093 [POSTER 1520]

Tissue mechanics driven symmetry breaking and cellular
reprogramming during regenerative wound healing
H. Harn1, C. Huang1, 2, 3, C. Chen1, 4, A. Sarkar5, B. Van Handel5,
T. E. Woolley6, D. Evseenko5, C. Chuong1
1
Pathology, Keck School of Medicine, University of Southern California,
Los Angeles, California, United States, 2Ostraw School of Dentistry,
University of Southern California, Los Angeles, California, United States,
3
Division of Cardiovascular Surgery, Department of Surgery, Tri-Service
General Hospital, National Defense Medical Center, Taipei, Taiwan, 4The
IEGG and Animal Biotechnology Center, National Chung Hsing University,
Taichung, Taiwan, 5Orthopaedic Surgery, Keck School of Medicine,
University of Southern California, Los Angeles, California, United States,
6
Cardiff University School of Mathematics, Cardiff, United Kingdom

14:35-14:45
13:45-13:55

ORAL 092 [POSTER 1493]

Dynamic changes in fibroblast subpopulations drives development ofradiation-induced skin fibrosis through the fra/c-jun pathway
D. C. Wan, M. Griffin, C. E. Berry, M. T. Longaker
Surgery, Stanford University School of Medicine, Stanford, California,
United States

ORAL 094 [POSTER 1541]

Co-transcription factors YAP and TAZ regulate dermal extracellularmatrix homeostasis and scar formation in mouse skin
A. Ermilov, Z. Qin, A. Kim, T. Quan, J. J. Voorhees, G. J. Fisher
Dermatology, University of Michigan, Ann Arbor, Michigan, United States

14:45-14:55

ORAL 095 [POSTER 1453]

LncRNA SNHG26 facilitates inflammatory to proliferative statetransition of keratinocyte progenitors during wound healing
D. Li1, 2, Z. Liu2, L. Zhang2, X. Bian2, J. Wu3, L. Li1, L. Pan1, Y. Xiao1,
J. Wang1, X. Zhang1, W. Wang4, M. Toma2, M. Piipponen2, L. Luo2,
P. Sommar2, N. Xu Landén2
1
Affiliated Hospital for Skin Diseases of Chinese Academy of Medical
Sciences, Nanjing, Jiangsu, China, 2Karolinska Institutet, Stockholm,
Stockholm, Sweden, 3Wenzhou Medical University, Wenzhou, Zhejiang,
China, 4East China Normal University, Shanghai, Shanghai, China

Continued on next page.

52

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 6 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
13:15 – 15:45
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:55-15:05

ORAL 096 [POSTER 1506]

Multimodal transcriptomics highlight fibroblast heterogeneity andpathological signaling networks in keloid
Y. Liu1, 2, C. F. Guerrero-Juarez2, Q. Nie2, J. Li1, M. Plikus2
1
Xiangya Hospital Central South University, Changsha, Hunan, China,
2
University of California Irvine School of Biological Sciences, Irvine,
California, United States

15:05-15:15

ORAL 097 [POSTER 1519]

Topical type VII collagen increased elastic fiber formation, accelerated
wound closure and reduced scarring of diabetic pigskin wounds
D. Woodley, Y. Hou, X. Tang, C. Tan, K. Zhang, L. Bainvoll, W. Li,
M. ChenDermatology, University of Southern California, Los Angeles, California,
United States

15:15-15:25

ORAL 098 [POSTER 1500]

FoxO3a-regulating mitochondrial dynamics affects wound healing
through regulating fibroblast migration
S. Goto1, M. Moriyama2, M. Wakatake3, Y. Miyake1, H. Moriyama1
1
Kinki Daigaku, Higashiosaka, Osaka, Japan, 2Kinki Daigaku,
Higashiosaka, Osaka, Japan, 3Kinki Daigaku, Higashiosaka, Osaka,Japan

15:25-15:35

ORAL 099 [POSTER 1507]

MCSP+ pericytes on the dermal capillary loop as a potential sourcefor epidermal stem/ progenitor cells and their reduction with age
M. Sawane, T. Tsutsui, M. Komata, R. Kami, H. Aoki, K. Kajiya
MIRAI Technology Institute, Shiseido Co., Ltd, Yokohama, Japan

15:35-15:45

ORAL 100 [POSTER 1455]

Identification and characterization of specific subsets in systemicsclerosis fibroblast cultures
A. S. Rosendahl1, K. Schönborn1, N. Kleinenkuhnen2, T. Baar2,
A. Tresch2, B. Eckes1, P. Moinzadeh3, T. Krieg1
1
Translational Matrix Bioogy, Faculty of Medicine, Universitat zu Koln,
Koln, Nordrhein-Westfalen, Germ any, 2Institute of Medical Statistics andComputational Biology, Universitat zu Koln, Koln, Nordrhein-Westfalen,
Germany, 3Department of Dermatology, Universitat zu Koln, Koln,
Nordrhein-Westfalen, Germany

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING53

ESDR Rudi Cormane Lecture

Deciphering Pathways in the Syndromic Keratodermas:
Insights into Oesophageal Cancer––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
15:55 – 16:25
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Sabine Eming

David Kelsell, PhD/BSc
Queen Mary University or London, London, UK
My research largely focuses on the molecular mechanisms underlying
inherited non-syndromic and syndromic skin disease including in
the palmoplantar keratodermas and the ichthyoses. This has led to
key scientific findings not only in skin biology but in hearing loss,
cardiomyopathy and oesophageal cancer. These cross-clinicaldisciplinary human studies are providing novel insights into disease
and their underlying cellular mechanisms. In addition to human biopsy
material, we have developed model systems to provide new biology andinsights into disease of the naturally stressed palm/sole skin, the heart
and the oesophagus.
I am based within the Blizard Institute in the Faculty of Medicine andDentistry at Queen Mary University of London (https://www.qmul.ac.uk/
blizard/all-staff/profiles/david-kelsell.html). I was awarded the ChanelCERIES award research award in 2016, ESPD Schnyder Memorial
Prize Lecture in 2018 plus past President (2018-2019; first non-clinicalpresident) of the European Society of Dermatological Research.

LECTURESHIP HISTORYThe Rudi Cormane Lecture is ESDR’s most prestigious lecture. It is given
by an internationally recognized individual who has made a significant
contribution to the ESDR and who has carried out high quality science
relevant to dermatology. Prof Rudi Cormane (1925-1987) was a founding
member of the ESDR as well as serving as its Treasurer and President.

54

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGSanofi K. K. Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
16:30 – 18:00
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Skin Barrier, Neuroimmune Axis, and Type 2 Inflammation in Atopic
Dermatitis: Research breakthroughs leading to therapeutic innovations forpatients with atopic dermatitis
CHAIR:
Masayuki Amagai, MD/PhD, Professor, Department of Dermatology, Graduate School of
Medicine, Keio University, Tokyo, JAPAN

Role of Type 2 Inflammation in Chronic Inflammatory Diseases		Constance Katelaris, MBBS PhD FRACP, Professor, Immunology & Allergy, Universityof Western Sydney, Head of Unit and Senior Staff Specialist at Campbelltown Hospital,
Sydney, AU. Dr. Katelaris is a leader in the field of allergy and immunology and has held
various executive positions on international and regional boards, including the World Allergy
Organization board, past president of the Asian Pacific Association of Allergology, Asthma
and Clinical Immunology and the Australasian Society of Clinical Immunology and Allergy.
She is the convenor of the Graduate Certificate in Allergic Diseases, the first postgraduate
course in the Faculty of Medicine, at Western Sydney University. Her research focuses on
conditions driven by type 2 inflammation, and she has participated in clinical trials of newtreatments for asthma, urticaria, angioedema, and atopic dermatitis.

Importance of Skin Barrier Dysfunction in Driving AD Pathophysiology
Lisa A. Beck, MD, Professor, Carol & Lowell Goldsmith Professor of Dermatology, Professor,
Allergy/Immunology and Rheumatology and Pathology, University of Rochester Medical
Center, New York, USA. Dr. Beck was instrumental in the development of the first biologic
drug, dupilumab, for the treatment of adults with moderate-to-severe atopic dermatitis. She
has received NIH funding since 1994 to study allergic inflammation, epithelial barrier function
in hopes of better understanding of why AD patients are susceptible to bacterial and viral
infections. She has published over 140 research papers, 15 chapters or review articles, 11
editorials and holds two patents. She is part of the NIAID-funded AD Research Network. Her
work has been recognized by numerous awards including honorary memberships (ADA andCollegium Internationale Allergologicum) and numerous named lectureships.

Connection Between Type 2 Inflammation and the Neuroimmune Mechanisms
and Pruritus in AD
Tilo Biedermann, MD, Professor, Dermatology and Allergology, TUM School of Medicine,
Munich, DE. Dr. Biedermann is a renowned dermatologist and allergologist who hasreceived multiple awards and has given several prestigious lectures. He is currently thechairman at TUM School of Medicine and has served as president of the European Societyof Dermatological Research (ESDR) and the German Dermatological Society (DDG). Prof.
Biedermann's research focuses on the connection between type 2 inflammation and theneuroimmune mechanisms and pruritus in atopic dermatitis. He has published in several
high-ranking peer-reviewed journals and leads several basic research projects funded by theGerman Research Foundation.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

55

Select ePoster Discussions, Session 1

Adaptive and Auto-Immunity 1 & 2
Studies of adaptive immune responses involving T and B lymphocytes, dendritic cells, other antigen presenting cells, and antigen
processing and presentation; Basic and pre-clinical experimental studies focused on autoimmunity.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #1––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Hayato Takahashi, Dr. Sam Hwang, Dr. Manuela Pigors#037
The intra-niche activation of clonal CXCL13+CD4+ T cells in
tertiary lymphoid structures associated with non-healing blisters ofpemphigus
A. Lee1, 2, D. Han1, 2, T. Kim1, 2, S. Min1, 2, H. Kim1, 2, D. Kim1, 3, S. Kim1, J.
Kim1, 2
1
Dermatology and Cutaneous Biology Research Institute, Yonsei
University College of Medicine, Seodaemun-gu, Seoul, Korea (theRepublic of), 2Gangnam Severance Hospital, Seoul, Korea (the Republicof), 3Severance Hospital, Seodaemun-gu, Seoul, Korea (the Republic of)#064
CD301b+ dermal dendritic cells drive activation of cytotoxic T
lymphocytes in a murine contact dermatitis
F. Minami1, R. Asahina1, S. Ono1, T. Honda2, G. Egawa1, S. Nakamizo1,
K. Kabashima1
1
Kyoto Daigaku, Kyoto, Japan, 2Hamamatsu Ika Daigaku, Hamamatsu,
Shizuoka, Japan#003
Memory B cells of atopic individuals preferentially express IL-31RA:
a putative role of IL-31 in B cell biology
Z. Unger1, C. Gomez-Casado1, A. van Lierop1, G. Pongratz2, D. Bleck2,
B. Homey1
1
Dermatology, Universitatsklinikum Dusseldorf, Dusseldorf, NordrheinWestfalen, Germany, 2Hiller Research Center Rheumatology,
Universitatsklinikum Dusseldorf, Dusseldorf, Nordrhein-Westfalen,
Germany#070
Impact of autoantibodies on atopic dermatitis
T. Hisamoto1, H. Kotani1, K. M. Matsuda1, K. Yamaguchi2, N. Goshima2,
S. Sato1, A. Yoshizaki1
1
Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan, 2ProteoBridge Corporation,
Tokyo, Japan#121
Pharmacological inhibition of the neonatal Fc receptor reducesdisease activity in an antibody transfer-induced model of bullous
pemphigoid
M. Pigors1, S. Patzelt1, S. Khil'chenko1, M. Kamaguchi1, S. Emtenani1,
K. Vanderheyden2, B. Balbino2,
K. Bieber1, R. J. Ludwig1, P. Verheesen2, E. Schmidt1
1
Universitat zu Lubeck, Lubeck, Schleswig-Holstein, Germany, 2argenx
BV, Zwijnaarde, Belgium#168
TLR7-VGLL3 synergism potentiates lupus-like autoimmunity in mice
O. Plazyo1, K. Young1, A. Billi1, M. Gharaee-Kermani1, 2, R. Wasikowski1,
L. Tsoi1, J. M. Kahlenberg1, 2, J. Gudjonsson1
1
Dermatology, University of Michigan, Ann Arbor, Michigan, UnitedStates, 2Internal Medicine, Division of Rheumatology, University ofMichigan Michigan Medicine, Ann Arbor, Michigan, United States#056
IKZF1 and IKAROS overexpression contributes to the pathogenesisof alopecia areata
Y. Arakawa1, 3, R. Tamagawa-Mineoka1, M. Nakanishi1, H. Nishigaki1,
M. Y. Ueta2, N. Katoh1
1
Dermatology, Kyoto Furitsu Ika Daigaku, Kyoto, Japan,
2Ophthalmology, Kyoto Furitsu Ika Daigaku, Kyoto, Japan,
3
Dermatology, Kyoto Furitsu Ika Daigaku Fuzoku Hokubu Iryo Center,
Yosa-gun, Kyoto, Japan#039
Inhibitory effect on skin fibrosis by regulating Th17 and regulatory
T cell imbalance in a systemic sclerosis mouse model and the
involvement of alteration in the intestinal microbiota
A. Sekiguchi1, C. Shimokawa2, T. Kato3, H. Hisaeda2, H. Ohno3,
S. Motegi1
1
Dermatology, Gunma Daigaku Daigakuin Igakukei Kenkyuka Igakubu,
Maebashi, Gunma, Japan, 2Parasitology, Kokuritsu Kansensho Kenkyujo,
Shinjuku-ku, Tokyo, Japan, 3RIKEN Center for Integrative Medical
Sciences, Yokohama, Kanagawa, Japan#014
Sex as a variable in the composition of skin residing T cells
H. Koguchi-Yoshioka1, 2, E. Zhuravleva1, 3, W. Zheng1, 3, E. Hoffer1, 3,
J. Kärner1, A. O. Gadsboll3, J. Coquet3, 4, S. Nylén4, M. Ehrström5, 6,
J. Gahm5, L. Eidsmo1, 3
1Division of Rheumatology, Department of Medicine, Solna, Karolinska
Institutet, Solna, Sweden, 2Department of Dermatology, Course ofIntegrated Medicine, Graduate School of Medicine, Osaka University,
Suita, Osaka, Japan, 3LEO Foundation Skin Immunology ResearchCenter, Kobenhavns Universitet, Kobenhavn, Denmark, 4Departmentof Microbiology, Tumor and Cell Biology, Karolinska Institutet, Solna,
Sweden, 5Department of plastic surgery and craniofacial surgery,
Karolinska Institutet, Solna, Sweden, 6Plastic Surgery, Nordiska Kliniken,
Stockholm, Sweden

Continued on next page.

56

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Select ePoster Discussions, Session 1
Adaptive and Auto-Immunity 1 & 2 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #1––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#073
Arteriosclerosis derived from cutaneous inflammation is ameliorated
by the deletion of IL-17A or IL-17F
T. Nakanishi, S. Iida, Y. Matsushima, K. Mizutani, Y. Nakayama,
K. Sugioka, M. Nishimura, A. Umaoka, M. Kondo, K. Habe, K. Yamanaka
Department of Dermatology, Mie University Graduate School of
Medicine, Japan, Tsu, Japan#166
Granzyme K stimulates a novel pathway of complement activation
E. Theisen1, 2, C. Donado2, 3, A. Jonsson2, R. Clark2, M. Brenner2, 3
1
Havard Combined Dermatology Residency Program, Boston,
Massachusetts, United States, 2Brigham and Women's Hospital, Boston,
Massachusetts, United States, 3Harvard Medical School, Boston,
Massachusetts, United States#079
Generation and characterization of the Psmb8 G201V mutation
knock-in mice as a model for Nakajo-Nishimura syndrome
T. Hara1, T. Kato2, J. Hamazaki3, A. Kinoshita4, Y. Inaba1, I. Sasaki2,
K. Yoshiura4, M. Jinnin1, T. Kaisho2, N. Kanazawa1, 5
1
Dermatology, Wakayama Kenritsu Ika Daigaku, Wakayama, Japan,
2
Department of Immunology, Institute of Advanced Medicine,
Wakayama Kenritsu Ika Daigaku, Wakayama, Japan, 3Laboratory ofProtein Metabolism, Graduate School of Pharmaceutical Sciences,
Tokyo Daigaku, Bunkyo-ku, Tokyo, Japan, 4Department of Human
Genetics, Atomic Bomb Disease Institute, Nagasaki Daigaku, Nagasaki,
Japan, 5Department of Dermatology, Hyogo Ika Daigaku, Nishinomiya,
Hyogo, Japan#016
Immune competent skin organoids reveal monkeypox dynamics
A. J. Pavlovitch-Bedzyk1, S. M. Chirieleison1, H. Koehler3, C. Kuo2,
M. M. Davis1
1
Immunology, Stanford University, Stanford, California, United States,
2
Hematology, Stanford University School of Medicine, Stanford,
California, United States, 3School of Molecular Biosciences, Washington
State University, Pullman, Washington, United States#053
Conformational epitope mapping of autoantibodies against BP180 in
dipeptidyl peptidase-4 inhibitors-associated bullous pemphigoid
S. Mai, K. Izumi, Y. Mai, K. Natsuga, W. Nishie, H. Ujiie
Dermatology, Hokkaido Daigaku Daigakuin Igaku Kenkyuin, Sapporo,
Hokkaido, Japan#075
Cellular subsets and signaling pathways of IgA vasculitis revealed bysingle-cell RNA sequencing
D. Tie1, T. Nomura1, 2, R. Shibuya3, S. Nakamizo1, K. Kabashima1
1
Department of Dermatology, Kyoto University Graduate Schoolof Medicine, Kyoto, Japan, 2Department of Drug Development for
Intractable Diseases, Kyoto University Graduate School of Medicine,
Kyoto, Japan, 3Department of Dermatology, Icahn School of Medicine atMount Sinai, New York, New York, United States#170
A shared set of autoantigens is recognized in anti-tumor immunity
and autoimmune diseases of the skin
V. Walter, B. Balciunaite, S. Thomä, S. Hofmeister, G. Mroz, F.
Wolfsperger, M. Knoll, T. Amaral, U. Leiter-Stöppke, V. Aebischer, S.
Forchhammer, M. Schaller, L. Flatz
Eberhard Karls Universitat Tubingen, Tubingen, Baden-Württemberg,
Germany#160
Local precursors are capable of replenishing tissue-resident memory
T cells in healthy and diseased skin
E. Hoffer2, 1, W. Zheng1, 2, D. Sortebech2, 1, T. Schoenfeldt1,
S. Papavasileiou2, B. Zitti3, 4, R. Agerholm-Nielsen1, M. Ehrström5,
N. Odum1, P. Brunner6, C. Gerlach2, J. Lysell7, L. Eidsmo1, 2
1
Department of Microbiology and Immunology, Kobenhavns Universitet,
Kobenhavn, Denmark, 2Department of Medicine Solna, Karolinska
Institutet, Stockholm, Sweden, 3Department of Medicine Hudddinge,
Karolinska Institutet, Stockholm, Sweden, 4Department of Pathology
and Immunology, Universite de Geneve, Geneve, Switzerland, 5Nordiska
Kliniken, Stockholm, Sweden, 6Icahn School of Medicine at Mount Sinai,
New York, New York, United States, 7Department of Dermatology and
Venerology, Karolinska Institutet, Stockholm, Sweden#002
Gene flow from archaic hominins causes psoriasis, ankylosing
spondylitis, and Behçet's disease
A. Arakawa1, C. D. Huber2, J. C. Prinz1
1
Dermatology, Ludwig-Maximilians-Universitat Munchen, Munich,
Bayern, Germany, 2Biology, The Pennsylvania State University,
Pennsylvania, Pennsylvania, United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

57

Select ePoster Discussions, Session 1

Clinical Research-Epidemiology and Observational Research 1 & 2
Non-interventional studies of populations or patient cohorts that evaluate, but are not limited to, the natural history of disease,disease burden, co-morbidities, health-related quality of life, and patient-reported outcomes research.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #2––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Young Lee, Dr. Marie-Charlotte BrÜggen, Dr. Helmut Schaider,
Dr. Howa Yeung#563
Increased incidence of cutaneous melanoma and merkel cell
carcinoma in subgroups of patients with primary cutaneous B-cell
lymphoma: A SEER database analysis
L. Banner, D. Joffe, E. Lee, N. Nikbakht
Dermatology and Cutaneous Biology, Thomas Jefferson University,
Philadelphia, Pennsylvania, United States#411
Associations between immune-related diseases and skin cancer: An
analysis of the diverse All of US research program
E. M. Lin, S. D. Ragi, I. Moseley, R. K. Lim, A. Qureshi, E. Cho
Dermatology, Brown University Warren Alpert Medical School,
Providence, Rhode Island, United States#475
Skin of color and mucocutaneous ulcers are associated with increased
disease severity in anti-NXP2 dermatomyositis patients
C. Bax, G. Molina, D. Fiorentino
Stanford University, Stanford, California, United States#485
Sleep disturbance impacts physical and psychosocial health ofchildren with atopic dermatitis
C. Mann2, Z. Ren1, S. Rangel1, A. Paller1
1
Dermatology, Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States, 2Dermatology, Johannes Gutenberg
Universitat Mainz, Mainz, Rheinland-Pfalz, Germany#461
Total serum IgE levels as a predictor for clinical response toomalizumab in patients with chronic spontaneous urticaria: A
systematic review and meta-analysis
K. Chuang1, C. Hsu2, S. Huang3, H. Chang4, 5, 6
1
Department of General Medicine, Taipei Medical University Hospital,
Taipei, Taiwan, 2Department of Dermatology, Hokkaido Daigaku, Sapporo,
Hokkaido, Japan, 3Department of Medical Research, Taipei Medical
University Hospital, Taipei, Taiwan, 4Department of Dermatology, Schoolof Medicine, College of Medicine, Taipei Medical University, Taipei,
Taiwan, 5Department of Dermatology, Taipei Medical University Hospital,
Taipei, Taiwan, 6Department of Pharmacology, College of Medicine,National Taiwan University, Taipei, Taiwan#408
Disaggregated analysis of Asian ethnicities reveals disparities inmelanoma treatment timeliness
L. S. Fane1, A. Wei1, R. Tripathi2, J. S. Bordeaux31Case Western Reserve University School of Medicine, Cleveland, Ohio,
United States, 2Johns Hopkins Medicine, Baltimore, Maryland, UnitedStates, 3University Hospitals, Cleveland, Ohio, United States#561
Can systemic levels of BNP predict itch severity?
L. A. Nattkemper, G. Yosipovitch
Dermatology, University of Miami School of Medicine, Miami, Florida,
United States#442
The influence of psoriasis on clinical outcomes following burn Injury
D. Garate, D. Thomas, I. Flores, B. Morgan, G. Golovko, A. El Ayadi,
J. Song, S. Wolf
The University of Texas Medical Branch at Galveston School of Medicine,
Galveston, Texas, United States#419
Comparison of topical fluorouracil and cryotherapy in Medicare
patients with actinic keratoses: A retrospective cohort study
M. K. Nowakowska1, Y. Li2, L. Wheless3, M. Wehner2
1
Baylor College of Medicine, Houston, Texas, United States, 2The
University of Texas MD Anderson Cancer Center, Houston, Texas, UnitedStates, 3Vanderbilt University Medical Center, Nashville, Tennessee,
United States#565
Assessing postoperative complication risk in patients withpre-existing diabetes mellitus who undergo mohs micrographic
surgery
D. Garate, D. Thomas, M. G. Wilkerson
The University of Texas Medical Branch at Galveston School of Medicine,
Galveston, Texas, United States#473
Clinical characteristics and risk of second malignancies ofextramammary paget’s disease patients in Canada and Japan
F. Al Ghazawi
Dermatology, University of Ottawa, Ottawa, Ontario, Canada

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1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Select ePoster Discussions, Session 1
Clinical Research-Epidemiology and Observational Research 1 & 2 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #2––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#463
Comorbid conditions associated with alopecia areata: A systematic
review and update
S. Ly1, 2, P. Manjaly1, K. Kamal1, A. Shields1, B. Wafae1, N. Afzal1,
L. Drake1, K. Sanchez1, S. Gregoire1, G. Zhou1, A. Mostaghimi11Dermatology, Brigham and Women's Hospital, Boston, Massachusetts,
United States, 2University of Arkansas for Medical Sciences College ofMedicine, Little Rock, Arkansas, United States#513
Zinc dyshomeostasis in patients with bullous pemphigoid andBP180-deficient mice
C. Chu1, 2, G. Liu1, J. Wang1, M. Huang1, C. Yang1, 3
1
National Cheng Kung University Hospital, Tainan, Taiwan, 2Instituteof Basic Medical Sciences, National Cheng Kung University College ofMedicine, Tainan, Taiwan, 3National Cheng Kung University International
Center for Wound Repair and Regeneration, Tainan, Taiwan#426
Association of stratum corneum and breast milk factors with thedevelopment of atopic dermatitis in infancy: A prospective birthcohort study
R. Fukuda1, K. Pak2, N. Mochimaru1, R. Tanaka1, M. Kiuchi3, N. Hirata3,
M. Mitsui4, Y. Ohya5, K. Yoshida1, 5
1
Department of Dermatology, National Center for Child Health andDevelopment, Tokyo, Japan, 2Division of Biostatistics, Departmentof Data Management, Center of Clinical Research and Development,
National Center for Child Health and Development, Tokyo, Japan,
3
Pigeon Corporation, Tokyo, Japan, 4Center for Maternal-Fetal, Neonatal
and Reproductive Medicine, National Center for Child Health andDevelopment, Tokyo, Japan, 5Allergy Center, National Center for Child
Health and Development, Tokyo, Japan#392
Hair loss after drug reaction with eosinophilia and systemic
symptoms: A multicentric retrospective study
J. Lee1, D. Yu2, S. Cho3, S. Youn4, O. Kwon1
1
Department of Dermatology, Seoul National University College ofMedicine, Seoul, Korea (the Republic of), 2Department of Dermatology,
Konkuk University School of Medicine, Seoul, Korea (the Republic of),3
Department of Dermatology, Seoul Metropolitan Government Seoul
National University Boramae Medical Center, Seoul, Korea (the Republicof), 4Department of Dermatology, Seoul National University Bundang
Hospital, Seongnam, Korea (the Republic of)#452
Validation of LRINEC score and establishment of novel score in
Japanese patients with necrotizing fasciitis
Y. Norimatsu1, 2, 3, Y. Ohno3, Y. Norimatsu4, A. Yoshizaki-Ogawa2,
T. Miyagawa2, K. Oba5, S. Sato2, A. Yoshizaki2
1
Dermatology, Kokusai Iryo Fukushi Daigaku Narita Byoin, Narita, Chiba,
Japan, 2Dermatology, University of Tokyo Graduate School of Medicine,
Bunkyo Ku, Tokyo, Japan, 3Dermatology, JR Tokyo Sogo Byoin, Shibuyaku, Tokyo, Japan, 4Dermatology, The Fraternity Memorial Hospital,
Sumida-ku, Tokyo, Japan, 5Department of Biostatistics, School of Public
Health, University of Tokyo Graduate School of Medicine, Bunkyo-ku,
Tokyo, Japan

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

#468
Use of calcitonin gene-related peptide monoclonal antibodies inpatients with rosacea: An exploratory, comparative case series
T. Sia1, T. Webb1, S. Li1, 2, L. Moskatel3, A. L. Chang1
1
Dermatology, Stanford Medicine, Stanford, California, United States,
2
Urology, Stanford Medicine, Stanford, California, United States,
3
Neurology and Neurological Sciences, Stanford Medicine, Stanford,
California, United States

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

59

Select ePoster Discussions, Session 1

Tissue Regeneration and Wound Healing/Skin, Appendages,& Stem Cell Biology
Wound healing and regeneration studies; processes/signaling that regulate vascular development and angiogenesis; interactions between different
skin components that contribute to the functional process of wound healing or tissue regeneration/Studies on the hair follicle, sebaceous gland,and other skin appendages; developmental biology of skin and hair; roles of stem cells in pre- and post-natal growth and development.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #3––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Doyoung Kim, Dr. Bethany Perez-White, Dr. Hisham Bazzi#1458
Dissection of the molecular and cellular heterogeneity of dermal
fibroblasts in skin fibrosis
A. Ahmed, T. Kirk, L. Forster, E. O'Toole, H. Gupta, E. Rognoni
Queen Mary University of London, London, London, United Kingdom#1446
RNase L acts as a regeneration suppressor
C. Kirby1, N. Islam1, E. Wier1, M. P. Alphonse1, E. Sweren1,
G. Wang1, H. Liu1, D. Kim1, A. Li1, S. Lee1, Y. Xue1, S. Reddy4, L. Miller1,
J. Yu2, W. Huang2, J. W. Jones2, S. Kim3, M. Kane2, R. H. Silverman5,
L. A. Garza1
1
Dermatology, Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States, 2Pharmaceutical Sciences, University of
Maryland Baltimore, Baltimore, Maryland, United States, 3Jeonju
University, Jeonju, Jeollabuk-do , Korea (the Republic of), 4Plastic
Surgery, Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States, 5Cleveland Clinic, Cleveland, Ohio, United States#1516
Genetic mouse models and a new pro-lymphangiogenic treatment
approach reveal beneficial effects of lymphatic vessel activation in
cutaneous wound healing
L. M. Brunner, Y. He, N. Cousin, L. Albin, B. Schmucki, S. Supersaxo,
D. Neri, M. Detmar
Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland#1473
Hippo pathway drives excessive fibrosis in hidradenitis suppurativa
K. R. van Straalen1, 2, F. Ma3, M. Calbet4, M. Gharaee-Kermani1, 3,
R. Wasikowski1, A. Billi1, P. Tsou3, L. C. Tsoi1, J. Gudjonsson11
Dept of Dermatology, University of Michigan Medical School, Ann Arbor,
Michigan, United States, 2Dept of Dermatology, Erasmus University
Medical Center, Rotterdam, Netherlands, 3Div of Rheumatology, Deptof Internal Medicine, University of Michigan Medical School, Ann Arbor,
Michigan, United States, 4R&D Center, Almirall SA, Barcelona, Catalunya,
Spain

#1539
A paradigm shift: Inflammatory response in chronic wounds halts
progression of healing
A. Sawaya1, J. Marjanovic1, R. C. Stone1, I. Jozic1, J. Burgess1,
H. Brem2, H. Lev-Tov1, R. S. Kirsner1, M. I. Morasso3, I. Pastar1,
M. Tomic-Canic1
1
University of Miami School of Medicine, Miami, Florida, United States,
2
RWJBarnabas Health, Newark, New Jersey, United States, 3National
Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda,
Maryland, United States#1468
Lymphatic dysfunction affects both collagen degradation andcollagen synthesis, leading to a paradoxical reduction in dermal
fibrosis
M. Sugaya1, H. Kusano2, T. Shiomi2, W. Nishimura3, A. Blauvelt4
1
Department of Dermatology, International University of Health andWelfare, Narita, Japan, 2Department of Pathology, International University
of Health and Welfare, Narita, Japan, 3Department of Molecular Biology,
International University of Health and Welfare, Narita, Japan, 4Oregon
Medical Research Center, Portland, Oregon, United States

1511
Macrophages regulate endothelial progenitors’ quiescence andself-renewal during homeostasis and cutaneous wound healing via
paracrine signaling
S. Sim2, S. Kaur1, C. Styke2, S. Millard1, A. Blumenthal2, A. Pettit1,
K. Khosrotehrani2
1
Mater Research Institute The University of Queensland, Brisbane,
Queensland, Australia, 2UQ Frazer Institute, The University of Queensland,
Brisbane, Queensland, Australia#1482
Physical stress reveals stem cell resources in nailH. Kosumi1, M. Watanabe1, T. Seo1, T. Nohara1, C. Shiiya1, H. Kitahata2,
Y. Hong3, 4, C. Hsu3, 4, 5, H. Ujiie1, K. Natsuga1
1
Department of Dermatology, Hokkaido Daigaku Daigakuin Igaku
Kenkyuin, Sapporo, Hokkaido, Japan, 2Chiba Daigaku, Chiba, Japan,
3
National Cheng Kung University Hospital, Tainan, Taiwan, 4National
Cheng Kung University International Center for Wound Repair andRegeneration, Tainan, Taiwan, 5Institute of Clinical Medicine, College ofMedicine, National Cheng Kung University, Tainan, Taiwan#1479
The cutaneous ischemia-reperfusion injury-induced pressure ulcer
was attenuated in amyotrophic lateral sclerosis mice model via
decreased nerve neurons and neuro peptides resulting in suppressing
oxidative stress
A. Uchiyama, A. Sekiguchi, S. Motegi
Dermatology, Gunma Daigaku, Maebashi, Gunma, Japan60

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Continued on next page.

Select ePoster Discussions, Session 1
Tissue Regeneration and Wound Healing/Skin, Appendages,& Stem Cell Biology - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #3––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#1440
DNA dioxygenases Tet2/3 regulate gene promoter accessibility andchromatin topology in lineage-specific loci to control keratinocyte
differentiation and hair growth
G. Chen1, I. Fatima1, Q. Xu2, E. Rozhkova1, M. Fessing3, A. Mardaryev3,
A. Sharov1, G. Xu2, 4, V. A. Botchkarev1
1
Dermatology, Boston University, Boston, Massachusetts, United States,
2
Shanghai Institutes Biological Sciences Chinese Academy of Sciences,
Shanghai, China, 3University of Bradford, Bradford, West Yorkshire,
United Kingdom, 4Fudan University, Shanghai, China#1349
Inducing fate changes at the hair follicle stem cell nice
Z. Lim1, T. Tien1, 2, C. Clavel1, 2
1
A*STAR Skin Research Labs, Agency for Science Technology andResearch, Singapore, Singapore, 2Lee Kong Chian School of Medicine,
Nanyang Technological University, Singapore, Singapore#1391
Cell death functions in hair follicle regeneration
G. Mantellato, A. S. Rosendahl, C. Niemann
University of Cologne Center for Molecular Medicine Cologne, Cologne,
Nordrhein-Westfalen, Germany#1428
DKK2 and SOSTDC1 cooperate to initiate the first catagen phase of
the hair follicle growth cycle
A. Ho1, 2, M. Xu1, 2, D. Wu3, G. Loots4, S. Millar1, 2
1Black Family Stem Cell Institute, Icahn School of Medicine at Mount
Sinai, New York, New York, United States, 2Department of Cell,
Developmental and Regenerative Biology, Icahn School of Medicine atMount Sinai, New York, New York, United States, 3Pharmacology, Yale
School of Medicine, New Haven, Connecticut, United States, 4Lawrence
Livermore National Laboratory, Livermore, California, United States#1372
Modulation of YBX1 phosphorylation determines epidermal stem cellfunction
S. Sol1, K. Todorova1, S. Iriyama2, A. Mandinova1
1
MGH/Dermatology, Harvard Medical School, Boston, Massachusetts,
United States, 2Kabushiki Kaisha Shiseido Global Innovation Center,
Yokohama, Kanagawa, Japan#1378
A multi-omics approach to identifying factors involved in hair follicle
growth and development
N. Pantelireis1, 2, E. Wang3, T. Tien1, A. Ramasamy1, G. Oguz1,
C. Higgins2, C. Clavel1
1
Agency for Science Technology and Research, Singapore, Singapore,2
Imperial College London, London, United Kingdom, 3National Skin
Centre, Singapore, Singapore#1346
Functional roles of Krox20 (Egr2) in Epithelial Stem Cells
E. Ghotbi1, E. Tchegnon1, 4, C. Liao1, 5, L. Q. Le1, 2, 3
1
Dermatology, The University of Texas Southwestern Medical Center,
Dallas, Texas, United States, 2Hamon Center for Regenerative Scienceand Medicine, The University of Texas Southwestern Medical Center,
Dallas, Texas, United States, 3Simmons Comprehensive Cancer Center,
The University of Texas Southwestern Medical Center, Dallas, Texas,
United States, 4Genetics, Development and Disease Graduate Program,
The University of Texas Southwestern Medical Center, Dallas, Texas,
United States, 5Graduate Institute of Medical Sciences, College ofMedicine, Taipei Medical University, Taipei, Taiwan#1413
From force to fate: LINCing cell junctions to nuclear morphology
A. Banerjee1, J. Ng1, R. Lim1, R. Biswas2, Y. Lee1, B. E. Burke1,
S. Raghavan1
1
Agency for Science Technology and Research, Singapore, Singapore,2
University of California San Francisco, San Francisco, California, UnitedStatesSelected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Select ePoster Discussions, Session 1

Carcinogenesis and Cancer Genetics/Photobiology/Skin of ColorStudies on the genetics and other causes of cancer as well as mechanisms relevant to metastasis/ Studies on biological, biochemical, andmolecular responses to ultraviolet radiation in cells, animals and humans/ Studies of the pathogenesis or treatment of skin diseases that
disproportionately affect patients from, or are more severe in their manifestation in, racial/ethnic groups with skin of color; such as keloids,
scarring alopecias, disorders of pigmentation, systemic lupus erythematosus, dermatomyositis, among others.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #4––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Jong Hee Lee/Snehlata Kumari, Dr. Nabiha Yusuf, Dr. Beate
Lichtenberger#291
Dysregulation of N6-methyladenine DNA methylation as a new
epigenetic mechanism in skin tumorigenesis
Y. Cui1, E. Wilkinson1, J. Peterson2, Y. He1
1
Medicine, The University of Chicago, Chicago, Illinois, United States,
2
The College, The University of Chicago, Chicago, Illinois, United States#271
The invasive niche confers resistance to therapy in basal cell
carcinoma
C. Pich, L. Yerly, J. Di Domizio, S. Tissot, M. Gilliet, F. Kuonen
CHUV, Lausanne, Switzerland#308
Immuno cancer-associated fibroblasts are a major source ofcytokines in malignant skin cancer
B. Aschenbrenner1, A. Forsthuber1, K. Purkhauser1, N. Krajic1, S. Frech1,
A. Soler Cardona1, P. Petzelbauer1, M. Kasper2, B. M. Lichtenberger1
1
Dermatology, Medizinische Universitat Wien, Wien, Austria, 2Karolinska
Institutet, Stockholm, Sweden#256
Non-canonical control of hedgehog signaling in skin basal cell
carcinoma
S. Krantz, R. Iglesias-Bartolome
LCMB, National Cancer Institute, Bethesda, Maryland, United States#232
Epidermal mutation accumulation in photodamaged skin is associatedwith skin cancer burden and can be targeted through ablative therapy
H. Wong1, R. Lee1, 2, S. Chong1, 2, S. Kapadia1, V. Murigneux3,
M. Freeman2, H. Soyer2, 4, E. Roy1, K. Khosrotehrani1, 2
1
Diamantina Institute, University of Queensland, Brisbane, Queensland,
Australia, 2Department of Dermatology, Princess Alexandra hospital,
Brisbane, Queensland, Australia, 3The University of Queensland
Institute for Molecular Bioscience, Saint Lucia, Queensland, Australia,
4
The University of Queensland Diamantina Institute, The Universityof Queensland, Dermatology Research Centre, Brisbane, Queensland,
Australia#236
Visualizing somatic alterations in spatial transcriptomics data of skincancer
L. Chen1, D. Chang1, B. Tandukar1, D. Deivendran1, R. Cho1, J. Cheng1,
B. Bastian1, A. Ji2, H. Shain1
1
Dermatology, University of California San Francisco, San Francisco,California, United States, 2Icahn School of Medicine at Mount Sinai, New
York, New York, United States#235
Distinct biological pathways associated with individual stages oftumor progression in KIT-altered melanoma
E. Everdell, Z. Ji, C. Njauw, H. Tsao
Dermatology, Wellman Center for Photomedicine, Boston,
Massachusetts, United States#293
Acidosis promotes immune escape through the IFN-γ-induced
induction of PD-L1 transcription in cancer cells
D. Stowbur7, 3, P. Knopf7, S. Hoffmann7, V. Buchner7, M. Poxleitner7,
I. Gonzalez-Menendez2, D. Kramer6, M. Schaller1, S. Forchhammer1,
L. Quintanilla-Martinez Fend2, K. Schulze-Osthoff3, 6, M. Pagel4,
A. Martins7, 3, M. Fransen5, B. Pichler7, 3, K. Ghoreschi8, M. Kneilling7, 3, 1
1
Dept. of Dermatology, University of Tübingen, Tübingen, Germany, 2Dept.
of Pathology, University of Tübingen, Tübingen, Germany, 3Cluster of
Excellence iFIT, Tübingen, Germany, 4Dept. of Cancer Systems Imaging,
MD Anderson Cancer Center, Houston, Texas, United States, 5LUMC,
Leiden, Germany, 6IFIB, University of Tübingen, Tübingen, Germany,
7
Werner Siemens Imaging Center, University of Tübingen, Tübingen,Germany, 8Charité, Berlin, Germany#274
Homologous recombination deficiency scores in AK and cSCC areassociated with tumor-immune phenotype
J. Thomson1, E. Healy3, J. Strid4, C. Harwood1, J. Wang2
1
Barts and The London School of Medicine and Dentistry Blizard
Institute, London, United Kingdom, 2Barts Cancer Institute Centre
for Molecular Oncology, London, United Kingdom, 3Department of
Dermatopharmacology, University of Southampton Faculty of Medicine,Southampton, United Kingdom, 4Imperial College London Department of
Immunology and Inflammation, London, United Kingdom

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Select ePoster Discussions, Session 1
Carcinogenesis and Cancer Genetics/Photobiology/Skin of Color - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #4––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#1178
Mechanisms of type I interferon-mediated UVB sensitivity in humankeratinocytes
N. Haddadi1, K. Afshari1, Y. Wang1, S. Sherman1, M. Garber1,
R. Vleugels2, M. H. Orzalli1, M. Rashighi1
1
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States, 2Brigham and Women's Hospital
Department of Medicine, Boston, Massachusetts, United States#1170
Investigating the molecular mechanisms of solar urticaria
M. Peake1, K. Rutter1, 2, N. Hawkshaw1, R. Scholey1, S. Bulfone-Paus1,
M. Farrar1, 2, L. E. Rhodes1, 2
1
The University of Manchester Faculty of Biology Medicine and Health,
Manchester, United Kingdom, 2Photobiology Unit, Salford Royal Hospital,
Salford, United Kingdom#1175
Impact of low dose UVA radiation on UVB radiation-induced DNA
damage and skin carcinogenesis
K. M. Rolfes, M. Pollet, J. Krutmann, T. Haarmann-Stemmann
IUF - Leibniz-Institut fur umweltmedizinische Forschung GmbH,
Dusseldorf, Nordrhein-Westfalen, Germany#1142
The IL-1α stimulated expression of the wrinkle-inducing elastaseneprilysin in adult human dermal fibroblasts is mediated via an
intracellular signaling axis of ERK/JNK/c-Jun/c-Fos/AP-1
U. C. Pinnawala1, M. Takada1, S. Hirano2, G. Imokawa1
1
Utsunomiya University, Utsunomiya, Tochigi, Japan, 2TourtVert Co, Ltd.,
Minoh, Osaka, Japan#1165
PDT-resistant skin tumor cells secrete CCL2 to induce TAMs
recruitment and suppressive tumor microenvironment
Y. Fu1, 2, J. Zhu1, 2, J. Tao1, 2
1
Department of Dermatology, Union Hospital, Tongji Medical College,
Huazhong University of Science and Technology, Wuhan, Hubei, China,
2
Hubei Engineering Research Center of Skin Disease Theranostics and
Health, Wuhan, China#1317
S6K2 is a vulnerability in MAPK-driven acral melanoma
R. Brathwaite1, 2, J. Villanueva2, 1
1
University of Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Wistar Institute, Philadelphia, Pennsylvania, United States#1292
Molecular phenotyping of keloid skin samples suggests polar
immune dysregulation
J. Bar1, 2, C. Rothenberg Lausell1, J. Wasserburg3, D. Gour1, Y. Liu1,
Y. Estrada1, A. Chowdhury1, P. Taub3, E. Guttman-Yassky1
1
Dermatology, Icahn School of Medicine at Mount Sinai, New York, New
York, United States, 2Tel Aviv University, Tel Aviv, Israel, 3Plastic andReconstructive Surgery, Mount Sinai Health System, New York, New
York, United States#1314
The JAK/STAT signaling pathway: Considerations in the managementof hidradenitis suppurativa in skin of color
C. A. Okeke1, C. Carmona-Rivera2, C. B. Oliveira2, M. Kaplan2,
G. Okoye1, A. Byrd1
1
Department of Dermatology, Howard University College of Medicine,
Washington, District of Columbia, United States, 2National Institute of
Arthritis and Musculoskeletal and Skin Diseases Systemic Autoimmunity
Branch, Bethesda, Maryland, United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

#1310
Characterization of differences in epidermal lipid composition
between psoriatic skin of color and white psoriatic skin
R. Haughton, S. Herbert, A. Ji-Xu, F. Patel, M. Cheng, E. Maverakis
Department of Dermatology, University of California Davis, Sacramento,
California, United States

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

63

Select ePoster Discussions, Session 1

Genetic Disease, Gene Regulation, and Gene Therapy
Studies on cutaneous gene expression (including genomic based studies) and genetic diseases including gene therapy.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––THURSDAY, MAY 11, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #5––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Rei Watanabe, Dr. Rui Yi, Dr. Fernando Larcher#818
Multi-condition TWAS for inflammatory skin disorders highlights
roles of genetic signals in cytokine-stimulated keratinocytes
H. Zhang1, M. T. Patrick1, M. Sarkar1, B. E. Perez White2, R. Uppala1,
K. He1, J. T. Elder1, X. Zhou1, J. Gudjonsson1, L. C. Tsoi1
1
University of Michigan, Ann Arbor, Michigan, United States,
2
Northwestern University, Evanston, Illinois, United States#862
Hedgehog signaling and ENPP1 role in epidermal proliferation andmelanin synthesis
M. Pavlovsky1, A. Peled1, O. Sarig1, L. Samuelov1, 2, E. Sprecher1, 2,
A. Taieb3, 4, J. Rambert5, M. Cario3, 4, 5
1
Division of Dermatology, Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel
Aviv University Sackler Faculty of Medicine, Tel Aviv, Israel, 3INSERM,
Bordeaux, France, 4National Reference Center for Rare Skin Disease,
Department of Dermatology, University Hospital Bordeaux, Bordeaux,France, 5Aquiderm, Bordeaux, France#903
Utilizing an organoid-based approach for the derivation of geneticallycorrected keratinocytes and fibroblasts in an induced pluripotent
stem cell therapy for skin diseases
M. Pavlova1, J. C. Flores1, V. Balaiya1, P. McGrath2, K. Carson
Butterfield1, S. McGarvey1, S. Vieau1, A. Bruckner3, I. Kogut1,
D. R. Roop1, G. Bilousova11
Department of Dermatology, University of Colorado Anschutz
Medical Campus School of Medicine, Aurora, Colorado, United States,2
Department of Pediatrics, University of Colorado Anschutz Medical
Campus, Aurora, Colorado, United States, 3Children's Hospital Colorado,
Aurora, Colorado, United States#878
CRISPR/Cas9 targeting an intronic region retrieving protein
expression in a compound heterozygous model mice via inducing
revertant mosaicism pathways
H. Nguyen1, Y. Ling2, K. Natsuga3, R. Hayashi1, R. Abe1, S. Shinkuma1, 41
Dermatology, Niigata University Graduate School of Medical and Dental
Sciences, Niigata, Japan, 2Medical AI Center, Niigata University Graduate
School of Medical and Dental Science, Niigata, Japan, 3Dermatology,
Faculty of Medicine and Graduate School of Medicine, Hokkaido
University, Sapporo, Japan, 4Dermatology, Nara Medical University,
Kashihara, Japan

64

#803
Editing a missense to a nonsense keratin 9 gene mutation restoresintermediate filament integrity
T. Trafoier1, D. Ortner-Tobider1, S. Hainzl2, T. Kocher2, U. Koller2,
J. Bauer2, M. Rhiel3, G. Andrieux4, T. Cornu3, T. Cathomen3, J. Reichelt5,
C. Heufler Tiefenthaler1, M. Schmuth1
1
Dermatology, Medizinische Universitat Innsbruck, Innsbruck, Tirol,
Austria, 2EB House, Paracelsus Medizinische Privatuniversitat, Salzburg,
Salzburg, Austria, 3Institute for Transfusion Medicine and Gene Therapy,
Universitatsklinikum Freiburg, Freiburg, Baden-Württemberg, Germany,
4
Institut of Medical Bioinformatics and Systems Medicine (IBSM),
Universitatsklinikum Freiburg, Freiburg, Baden-Württemberg, Germany,
5
Dermatology, Hamad Medical Corporation, Doha, Ad Dawhah, Qatar#899
Phenotypic and genomic characterization of eight patientswith patterned cutaneous hypopigmentation associated withextracutaneous findings
Z. Cai1, P. Campeau2, D. Marcoux2
1
Stanford University, Stanford, California, United States, 2Centre
Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, Canada#825
Basement membrane proteins in NF1-associated neurofibroma
extracellular matrix characterize tumor development and treatment
response to MEK inhibitor
C. Jiang, T. Shipman, Y. Wang, R. McKay, L. Q. Le
Dermatology, The University of Texas Southwestern Medical Center,
Dallas, Texas, United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGFRIDAY

MAY 12, 2023

FRIDAYYoung Investigator Collegiality Event––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023

19:50 – 21:50

CÉ LA VI TOKYO (18TH FLOOR OF TOKYU PLAZA SHIBUYA)		TOKYO, JAPAN––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––The organizers of the ISID are pleased to provide an opportunity for “younger” attendees of the ISID 2023
Meeting to enjoy an evening at CÉ LA VI, a luxury dining, bar and club lounge complex spread acrossthe 18th floor of the revamped Tokyu Plaza Shibuya. Overlooking Shibuya Crossing (the world’s busiest
pedestrian crossing, with as many as 3,000 people crossing at a time), the ISID event promises to bring
together attendees from all over the world to meet, network, and enjoy camaraderie throughout the evening.
Food and beverage will be provided at this event.
This party is a ticketed event and the cost to attend is $25 per person. Preference will be given to delegates
who are under 45 years of age and who have participated in one of the member society’s Resident Retreatsor Future Leaders programs. Those attending the event are responsible for their own transportation.
Check with the ISID Registration desk and ISID website for ticket availability.

SPONSORED BYISID Member Organizations
General Assemblies/Business Meetings––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
07:00 – 08:00
ROOM DETAILS BELOW, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

JSID General Assembly – Room B (Eminence Hall)

SID Business Meeting – Room C (Nishiki)

ESDR General Assembly – Room D (Ohgi)

TSID General Assembly – Room E (Moonlight)

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

67

ASA 2023 Research Achievement Awards Presentation––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
07:45 – 08:00
ROOM C:NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

2023 David Martin Carter Mentor Award
2023 George W. Hambrick Award
2023 Research Achievement Award in Autoimmune andInflammatory Skin Disorders
2023 Research Achievement Award in Skin Cancer andMelanoma2023 Research Achievement Award in Psoriasis
2023 Research Achievement Award in Vitiligo and Pigment
Cell Disorders
2023 Research Achievement Award in Public Policy andMedical Education
2023 Research Achievement Award in Discovery
2023 Research Achievement Award in Translational Research

For more information, contact Kathleen Reichert at kathleen@americanskin.org or Kristin Ludl at
kristin@americanskin.org
335 Madison Avenue, 22nd Floor, New York, NY 10017

68

212.889.4858

americanskin.org

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGPlenary Session 3––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
08:10 – 09:10
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Hsin-Su Yu, Dr. Jeffrey Travers, Dr. Enikö Sankoly

08:10-08:22

ORAL 101 [POSTER 025]

Interstitial lung disease based on autoimmunity against melanoma
differentiation-associated gene 5
Y. Ichimura1, 3, R. Konishi1, 3, T. Nomura3, M. Fujimoto2, N. Okiyama1
1
Department of Dermatology, Tokyo Ika Shika Daigaku Daigakin Ishigaku
Sogo Kenkyuka, Bunkyo-ku, Tokyo, Japan, 2Department of Dermatology,
Osaka Daigaku, Suita, Osaka, Japan, 3Department of Dermatology,
Tsukuba Daigaku Igaku Iryokei, Tsukuba, Ibaraki, Japan

08:46-08:58

08:58-09:10
08:22-08:34

ORAL 102 [POSTER 1164]

Naive HIF-1a/ AhR keratinocyte-conditional double knockout miceresemble UVB-irradiated wildtype mice
S. Fassbender1, 2, J. Schindler1, 2, H. Ramachandran1, T. Nguyen1,
M. Majora1, T. Haarmann-Stemmann1, C. Esser1, A. Rossi1,
H. Weighardt2, 1, J. Krutmann1
1
IUF – Leibniz-Institut fur umweltmedizinische Forschung GmbH,
Dusseldorf, Nordrhein-Westfalen, Germany, 2LIMES Life and Medical
Sciences Institute, Rheinische Friedrich-Wilhelms-Universitat Bonn,
Bonn, Nordrhein-Westfalen, Germany

08:34-08:46

ORAL 104 [POSTER 225]

Enhanced TLR7 immunity drives innate protection against
SARS-CoV-2 with chilblains as collateral damage.
A. Yatim1, 2, 3, F. Saidoune1, J. Di Domizio1, R. Jenelten1, A. Joncic1,
M. Morren1, C. Conrad1, J. Casanova2, 3, M. Gilliet1
1
Department of Dermatology, Centre Hospitalier Universitaire Vaudois,
Lausanne, Vaud, Switzerland, 2Institut Imagine Institut des Maladies
Genetiques, Paris, Île-de-France, France, 3The Rockefeller University,
New York, New York, United States

ORAL 105 [POSTER 732]

Dysregulated cytosolic Ca2+ concentration in channel-related
keratoses
T. Murata1, 2, N. Kanazawa1, K. Kabashima2
1
Department of Dermatology, Hyogo Medical University, Nishinomiya,
Japan, 2Department of Dermatology, Kyoto University, Kyoto, Japan

ORAL 103 [POSTER 539]

Multi-organ toxicities are associated with improved survival among
immune checkpoint inhibitor recipients: A population-level analysis
W. Chen1, 2, G. Wan1, 2, K. Roster1, N. Nguyen1, A. Rajeh1, H. Rashdan1,
M. Collier1, J. Seo1, N. LeBoeuf4, 2, S. Kwatra3, Y. Semenov1, 21
Massachusetts General Hospital, Boston, Massachusetts, UnitedStates, 2Harvard Medical School, Boston, Massachusetts, UnitedStates, 3Johns Hopkins University, Baltimore, Maryland, United States,
4Dana-Farber Cancer Institute, Boston, Massachusetts, United States

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

69

SID Special Guest Lecture

RNA origin of sex-biased immunity––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
09:15 – 09:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Ken Tsai

Howard Chang, MD/PhD
Stanford University, Palo Alto, CA
Howard Y. Chang MD/PhD is the Virginia and D.K. Ludwig Professorof Cancer Research and Director of the Center for Personal Dynamic
Regulomes at Stanford University. He is a Howard Hughes Medical
Institute Investigator; he is also Professor of Dermatology and of
Genetics at Stanford University School of Medicine. Chang earneda Ph.D. in Biology from MIT, M.D. from Harvard Medical School, andcompleted Dermatology residency and postdoctoral training at Stanford
University. His research addresses how large sets of genes are turned on
or off together, which is important in normal development, cancer, andaging. Chang discovered a new class of genes, termed long noncoding
RNAs, can control gene activity throughout the genome, illuminatinga new layer of biological regulation. He invented ATAC-seq and othernew methods for defining DNA regulatory elements genome-wide andin single cells. The long-term goal of his research is to decipher the
regulatory information in the genome to benefit human health.
Dr. Chang is a Member of the US National Academy of Sciences,
National Academy of Medicine, and American Academy for the Arts
and Sciences. Dr. Chang’s honors include the NAS Award for Molecular
Biology, Outstanding Investigator Award of the National Cancer
Institute, Paul Marks Prize for Cancer Research, Judson Daland Prizeof the American Philosophical Society, and the Vilcek Prize for Creative
Promise. His work was honored by the journal Cell as a Landmark paper
over the last 40 years and by Science as “Insight of the decade”.

70

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGKSID Special Guest Lecture

Adiponectin and Skin Diseases––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
09:45 – 10:15
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Eung Ho Choi

Jin-Ho Chung, MD/PhD
Seoul National University College of Medicine, Seoul, South Korea
Prof. Jin Ho Chung is currently the Professor and Chairperson of
Department of Dermatology, Seoul National University College ofMedicine, in Korea. His basic research interests lie in the field of skinaging, photobiology and photomedicine. On the clinical side, he has
been treating patients with various autoimmune bullous diseases andrheumatic skin diseases. He is a past President of Korean Society for
Investigative Dermatology (KSID).

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING71

Plenary Session 4––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
10:20 – 11:20
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Johannes Kern, Dr. Cory Simpson, Dr. Christoph Schlapbach

10:20-10:32

ORAL 106 [POSTER 916]

Activation of the pentose phosphate pathway in macrophages isessential for granuloma formation in sarcoidosis
S. Nakamizo1, G. Egawa1, Y. Ishida1, Y. Sugiura1, K. Kabashima1, 2
1
Kyoto Daigaku, Kyoto, Japan, 2Agency for Science, Technology andResearch, Singapore, Singapore

10:32-10:44

ORAL 107 [POSTER 1124]

Strong preclinical evidence for treatment efficacy of a novel immune
checkpoint inhibitor (ICI) in melanoma that targets a rare heparansulfateJ. Chung1, 2, S. Ung1, 2, J. Gill1, P. Cruz1, 2, K. Ariizumi1, 2
1
Dermatology, The University of Texas Southwestern Medical Center,
Dallas, Texas, United States, 2North Texas VA Medical Center, Dallas,
Texas, United States

10:44-10:56

10:56-11:08

11:08-11:20

ORAL 110 [POSTER 1567]

Single-cell rna sequencing reveals unique fibroblast subclusters inprurigo nodularis
J. R. Patel1, M. Joel1, K. Lee1, A. Kambala1, H. Cornman1, O. O. Oladipo1,
M. Taylor1, J. Deng1, V. Parthasarathy1, M. Marani1, S. Reddy1,
T. Pritchard1, V. Rebecca1, W. Ho1, M. Kwatra2, X. Dong1, S. Kang1,
S. Kwatra1
1
Dermatology, Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States, 2Duke University School of Medicine, Durham,
North Carolina, United States

ORAL 108 [POSTER 1431]

Skin aging and hair follicle stem cell dysfunction caused by T cellswith defective mitochondrial metabolism
E. Carrasco1, 2, 3, E. Gabandé-Rodríguez2, 4, G. Soto-Heredero2, 4,
M. M. Gómez de las Heras2, 4, M. Mittelbrunn2
1
Department of Biology, Faculty of Sciences, Universidad Autonoma
de Madrid, Madrid, Spain, 2Tissue and Organ Homeostasis Program,
Universidad Autonoma de Madrid Centro de Biologia Molecular Severo
Ochoa, Madrid, Spain, 3Experimental Dermatology, Instituto Ramon y
Cajal de Investigacion Sanitaria, Madrid, Spain, 4Department of Molecular
Biology, Faculty of Sciences, Universidad Autonoma de Madrid, Madrid,
Spain

72

ORAL 109 [POSTER 017]

A novel therapeutic strategy using stabilized antigen-specific iTreg
for pemphigus
M. Mukai1, H. Takahashi1, N. Mikami2, S. Sakaguchi2, M. Amagai11
Dermatology, Keio University School of Medicine, Tokyo, Japan,
2
Experimental Immunology, Osaka University IFReC, Osaka, Japan

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGTSID Special Guest Lecture

Precision Medicine of Common Diseases––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
11:20 – 11:50
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Fu-Tong Liu

Pui-Yan Kwok, MD/PhD
University of California, San Francisco, San Francisco, CA

Pui-Yan Kwok, MD/PhD, is the Henry Bachrach Distinguished Professor
at the University of California, San Francisco, and, since 2017, theDirector of the Institute of Biomedical Sciences at the Academia Sinica,
Taiwan.
Dr. Kwok received his MD and PhD degrees from the University of
Chicago, and residency in dermatology and postdoctoral training at the
Washington University School of Medicine.
Dr. Kwok’s research focuses on developing tools and strategies tostudy the human genome and the role of human variation in common
diseases. He played key roles in many large international consortia,
and he currently leads the Taiwan Precision Medicine Initiative, wherea reference database with genetic profiles and clinical data of 1 million
people is being built to improve health through disease risk prediction
and tailored heath management guidelines.
Dr. Kwok is an Academician of the Academia Sinica, a Fellow of theAmerican Association for the Advancement of Science, a Fellow of theWorld Academy of Sciences, and the recipient of the 2017 Universityof Chicago Pritzker School of Medicine Distinguished Service Awardand the 2022 Human Genome Organization (HUGO) Chen Award forDistinguished Academic Achievement in Human Genetic and Genomic
Research.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

73

Janssen Asia Pacific Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
12:05 – 13:05
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Janssen Symposium: Unlocking the IL-23 pathway: looking back tomove forward for psoriasis management
12:05 Welcome and introduction:
Akimichi Morita, MD/PhD, Professor and Chair, Department of Geriatric and Environmental
Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Professor Morita graduated from Nagoya City University and received his MD degree in 1989. Helater earned his PhD degree in basic immunology from Aichi Cancer Center in Nagoya. Professor
Morita is the current President of the Japanese Society for Psoriasis Research.
Objective: Welcome attendees and introduce programme
12:10 Past perspectives are key: IL-23 as the key cytokine in psoriatic disease:
Dan Cua, PhD, Vice President and IL-23 Pathway Area Leader, Immunology Therapeutic Area,
Janssen Research & Development, LLC. Dr. Cua oversees the design and implementation of
the scientific strategy for Discovery and Early and Late Clinical Development of Janssen’s IL-23
pathway programme. Dr Cua earned his PhD degree in molecular microbiology and immunology
from the University of Southern California (USC) School of Medicine. He also completed two
post-doctoral fellowships at the USC Department of Neurobiology within the School of Medicine
and at the DNAX Research Institute in Palo Alto, CA, USA.
Objective: Discuss the journey of IL-23, from its discovery to the impact it has had on the clinic.
12:20 The guiding light: disease memory and early intervention in psoriasis:
Andreas Pinter, MD/PhD, Senior Physician in Clinical Research, Department of Dermatology,
Venereology, and Allergology, Goethe University, Frankfurt am Main, Germany. He has held
this post since 2013. Dr Pinter studied medicine at the Goethe University and received training
in a number of European countries as well as in South Africa. Dr Pinter’s clinical and scientificactivities focus on the treatment of chronic inflammatory dermatoses, dermato-oncology, anddermatosurgery. He leads a scientific group for translational research, focusing on psoriasis andhidradenitis suppurativa.
Objective: Provide the latest insights on how early intervention by targeting the Th17/IL-23 pathway
could maintain long-term disease control.
12:30 Diverging threads: small changes, big implications?
James G. Krueger, MD/PhD, Head of the Laboratory for Investigative Dermatology, The
Rockefeller University, New York City, NY, USA. He also serves as Physician and Co-Directorof the Center for Clinical and Translational Science at the Rockefeller University Hospital, andas Chief Executive Officer of the Rockefeller University Hospital. Dr Krueger’s research group at
The Rockefeller University was the first to conduct clinical trials with specific, targeted immune
antagonists in psoriasis and establish that elimination of pathogenic T cells from skin lesions
could reverse the full pathological phenotype of psoriasis.
Objective: Provide new insights into the mechanisms of action of IL-23 inhibitors and discuss how
these mechanisms can potentially affect their therapeutic profiles of these drugs.
12:40 Looking forward: panel discussion and Q&A: All faculty; moderated by Prof. Morita
13:00 Closing remarks: Prof. Morita

74

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Nippon Boehringer Ingelheim Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
12:05 – 13:05
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Latest research on pustular skin diseases
CHAIR
Masashi Akiyama, MD/PhD, Professor, Department of Dermatology, Nagoya University
Graduate School of Medicine. Dr. Masashi Akiyama is a vice dean in the Graduate Schoolof Medicine and the chair and professor of the Department of Dermatology at Nagoya
University in Nagoya, Japan. His main research and clinical interests lie in the genetics of skindisorders, especially genetic keratinization diseases including ichthyoses, the mechanismsof keratinization and stratum corneum barrier function.

The Role of IL-36 in Pustular Psoriasis: What Have We Learnt from Genetic Studies?
Francesca Capon, PhD, Professor, Department of Medical and Molecular Genetics, King’s
College London. Professor Capon obtained a BSc in Biological Sciences (1992) and PhD
in Medical Genetics (1999) from “La Sapienza” University of Rome, Italy. Her interest in thegenetics of psoriasis brought her to the UK. She first moved to the University of Leicester asa Wellcome Trust Traveling Research Fellow (2001), then took on a Lectureship in Human
Molecular Genetics at University College London (2004). She joined King’s College London
in 2006 as a Lecturer, was then promoted to Senior Lecturer (2014), Reader (2018) andProfessor (2022).

The Role of Neutrophils in Skin Diseases
Tatsuyoshi Kawamura, MD/PhD, Professor and Chair, Department of Dermatology,
University of Yamanashi, Yamanashi, Japan. Dr. Kawamura graduated and received his
MD degree from Yamanashi Medical University in 1990, and subsequently pursued further
education in dermatology at Yamanashi Medical University, obtaining his PhD degree in
1998. Between 1998 and 2002, he served as a post-doctoral fellow at the National Cancer
Institute, Bethesda, Maryland. He was awarded the Fellows Award for Research Excellenceat the National Institute of Health in 2002. He has been Professor and Chair of the at the
Department of Dermatology, Yamanashi Medical University since 2017.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING75

No 7 Beauty Company Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
12:05 – 13:05
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Matrix-derived Cosmetic Peptides (matrikines) for the Rejuvenationof Photoaged Skin
12.05 – 12.10 Welcome:Mike Bell, PhD, Head of Science Research No7 Beauty Company, UK. Dr. Bell received his BSc in
Pharmacology at the University of Bath and a PhD in Neurobiology at Oxford University before
becoming interested in skin. He has been the industry lead for the established research collaboration
into healthy skin ageing with the University of Manchester, UK, since 2010 and with his science team
based in Nottingham, UK, works additionally with other academic institutions around the world on
both fundamental and translational skin research. His leadership on the science and technology
underpinning the No7 Skin care brand have helped elevate the brand to its current No1 market positionin the UK.
12.10-12.25 Predicting matrix-derived peptides using in silico machine learning approaches
Objective: How protein susceptibility algorithms and machine learning approaches can be used to
predict breakdown of extracellular matrix proteins and the release of putative bioactive peptides called’matrikines’.
		Mike Sherratt, BSc (Hons), PhD, PgCertHE, Professor of Biochemistry, University of Manchester, UK.
Dr. Sherratt’s research is focused on characterising the causative mechanisms and the structural andmechanical consequences of ageing in extracellular matrix rich tissues including skin, arteries, breastand cartilage. His lab has: i) developed novel atomic force microscopy and microCT methodologies tovisualise tissue architecture, ii) demonstrated that elastic fibre associated proteins are key targets ofboth ultraviolet radiation and oxidation, iii) shown that bioinformatic and mass spectrometry approaches
can be used to identify novel ageing biomarkers and fingerprints of damage and iv) demonstrated thatraised mammographic density (a risk factor for breast cancer) is associated with localised collagen
re-organisation and stiffening.
12.25 – 12.40 Novel peptides identified using machine learning approaches show wide-ranging
activity in cultured human dermal fibroblasts
Objective: Evidence that novel ‘matrikine’ peptides identified using machine learning approaches showdermal remodelling activity in vitro; utilising a range of techniques including omics.
Alexander Eckersley, PhD, Lecturer in Skin Health, University of Manchester, UK. Dr. Eckersley
pioneered the invention and development of “peptide location fingerprinting”, a new mass spectrometry
analysis technique capable of identifying damaged and modified proteins in complex biologicalsamples. His WBA-funded research has led to the identification of novel protein targets of ageing anddisease in skin, intervertebral disc, lung, artery and kidney, publishing several papers in distinguishedjournals such as Matrix Biology and Aging Cell. Alex won the prestigious Early-Career Award in 2019 at
the British Society for Proteome Research meeting and was awarded Seedcorn funding in 2020 from
the Manchester Institute for Collaborative Research on Ageing (MICRA). Alex has also contributed tothe design and proteomic testing of novel WBA skin ageing bioactives resulting in four patents.
12.40-12.55 A novel peptide-blend has potential as a topical anti-ageing cosmeceutical; Evidence
from a short-term patch test protocol for skin remodelling				
Objective: Evidence that a novel peptide-blend first identified using machine learning shows promise asa topical anti-ageing cosmeceutical, based on a validated short-term patch test protocol to assess skinremodelling in photoaged skin using immunohistochemical markers and transcriptomic characterisation.
Professor Rachel Watson, PhD, Executive Director, Skin Research Institute of Singapore (SRIS) andA*STAR Skin Research Laboratory (A*SRL). Dr. Watson was Professor of Cutaneous Science at the
University of Manchester, prior to her recent appointment as Executive Director of both the A*STAR
Skin Research Laboratory and the Skin Research Institute of Singapore (Republic of Singapore). She
received her BSc (Anatomy & Cell Biology) and PhD degrees from the University of Sheffield. Rachel
was instrumental to the development of the MSc in Skin Ageing & Aesthetic Medicine at the Universityof Manchester and continues to contribute, via editorial boards, to a number of prestigious international
journals, including the British Journal of Dermatology.

12.55 – 13.05 Cosmetic skincare applications and Q&A

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Shiseido Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
12:05 – 13:05
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Skin Beauty Provided by Healthy Blood and Lymphatic
Vascular Systems
CHAIR
Kenji Kabashima MD/PhD, Professor and Chairman, Department of Dermatology, Kyoto
University Graduate School of Medicine

The Importance of Blood Vessels and Lymphatic Vessels for Skin Health,
Aging and Beauty
Michael Detmar, MD, Professor, Institute of Pharmaceutical Sciences, ETH Zurich.
Dr. Detmar obtained his M.D. degree from the University of Freiburg, Germany. Since 2004,
he has been a Professor and Chair at the Swiss Federal Institute of Technology, ETH Zurich,where he currently leads a research team as professor emeritus. His lab has pioneered studiesof the role of cutaneous blood and lymphatic vessels in skin health, aging, inflammation andcancer. He has received several prestigious awards, including the 2005 Marion B. Sulzberger
Memorial Award and Lectureship of the American Academy of Dermatology and the 2007
Rudi Cormane Memorial Lectureship of the European Society for Dermatological Research. In
2015, he was elected as a member of the German National Academy of Sciences Leopoldina.
He is the author of more than 300 original publications and of several licensed patents.

Holistic Beauty by Promoting Blood/Lymphatic Vessel Function in Skin
Kentaro Kajiya, PhD, Vice President, Business Core Technology Center, Shiseido Co., Ltd.
He received his MSc. In 2001, from Tokyo University, Japan, and his PhD from the Tokyo
University of Agriculture and Technology in 2008. He started his career at Shiseido as a
Research Scientist in 2001, then as a Visiting Scientist at both Mass General Hospital andHarvard Medical School in 2003-2004; and the Swiss Federal Institute of Technology, ETH
Zurich in 2004-2005. He has been promoted several times at Shiseido since 2005, mostrecently being appointed as Vice President at the Business Core Technology Center in 2022.

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77

LEO Pharma Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
12:05 – 13:05
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Updated Information About the Roles of IL-13
in Atopic Dermatitis
CHAIRS
Takeshi Nakahara, MD/PhD, Department of Dermatology, Graduate School of Medical
Sciences, Kyushu University Fukuoka, Japan
Takeshi Nakahara graduated from School of Medicine, Kyushu University as an MD in 1999,
and received his PhD from Kyushu University in 2005. He worked under Dr. Alan N. Houghton
as a research fellow in Immunology Program, Memorial Sloan-Kettering Cancer Center, NewYork from 2005 to 2008. He was an assistant professor from 2008 to 2013, and an associate
professor from 2013 to 2022 at Department of Dermatology, Kyushu University. He has beena chairman and professor of Department of Dermatology, Kyushu University since 2022.
His interests are in the areas of atopic dermatitis, urticaria, and Aryl hydrocarbon receptor(AhR). He is focusing on skin immunology and allergy. He has been engaged in elucidating
the pathology of inflammatory skin diseases, mainly atopic dermatitis, and been developing
new therapeutic drugs. He has also contributed to Japanese guidelines for atopic dermatitis
and urticaria.
Chih-ho Hong, MD, Clinical Assistant Professor, Department of Dermatology and Skin
Sciences, University of British Columbia, Vancouver, Canada
Dr. Hong is a board certified dermatologist working in Greater Vancouver BC, Canada. He
runs a busy office based dermatology clinic with a focus on clinical research. He is a Clinical
Assistant Professor in the Department of Dermatology and Skin Sciences and teaches at St.
Paul’s Hospital in Vancouver, where he is active staff. Dr. Hong is the past head of the BC
Section of Dermatology and is the past chair of the Education Committee of the Canadian
Dermatology Association. He is also a past examiner in Dermatology for the Royal College ofPhysicians of Canada residency qualification examination. Dr. Hong is currently the Canadian
representative to SPIN (The Skin Inflammation and Psoriasis International Network www.
spindermatology.org) He is active in clinical practice and dermatology research. His main
clinical areas of interest are psoriasis and eczema. He has been an investigator in over 150
trials of treatments in dermatology and has over 50 peer reviewed publications. He has
lectured locally, nationally, and internationally on dermatology treatments and has been an
invited speaker at international dermatology congresses.
SPEAKER
Kenji Izuhara, MD/PhD, Division of Medical Biochemistry, Department of Biomolecular
Sciences, Saga Medical School, Saga, Japan.
Dr Izuhara received his MD and PhD degrees from Kyushu University, Fukuoka, Japan. He
joined DNAX Research Institute, Palo Alto, USA as Postdoctoral Fellow from 1991 to 1994.
He became Professor of Saga Medical School at 2000. He is now serving as Guest Professorof Juntendo University and a member of Science Council of Japan, Cabinet Office. His
research interests include clarification of the pathogenesis of allergic diseases and discoveryof drug targets and diagnostic markers for allergic diseases. He has published more than
250 peer-reviewed original articles and reviews in international journals and has contributed
to 45 books. He has given 117 plenary and invited Lectures in international and domestic
conferences and symposia by January 2023. He served as the Editor-in-Chief of Allergology
International from 2013 to 2019 and as the President of Japanese Society of Allergology
from 2019 to 2021.

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Torii Pharmaceutical Company, LTD. Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
12:05 – 13:05
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Understanding the Pathogenesis of Atopic Dermatitis
CHAIR
Norito Katoh, MD/PhD, Professor, Department of Dermatology, Kyoto Prefectural Universityof Medicine, Graduate School of Medical Science, Kyoto, Japan

SPEAKERS
Itch of Atopic Dermatitis and Janus Kinase: Chasing the Itch Jackpot
Takashi Hashimoto, MD/PhD, Associate Professor, Department of Dermatology, National
Defense Medical College, Tokorozawa, Japan.
Takashi Hashimoto, MD, PhD, is an Associate Professor at the Department of Dermatology at
National Defense Medical College, Tokorozawa, Japan. He received his MD in 2004 and PhD in2015 from Tokyo Medical and Dental University (TMDU). He completed his residency training
at TMDU in 2010 and is a board-certified dermatologist and allergist. From 2017 to 2019, heworked as a post-doctoral/visiting scholar in the Miami Itch Center under the mentorshipof the director Dr. Gil Yosipovitch, at the Dr. Phillip Frost Department of Dermatology andCutaneous Surgery at the University of Miami. His research interests involve the investigationof clinical, immunological, and neurophysiological mechanisms of itch and allergic cutaneous
diseases.

Impact of Staphylococcal Agr in Atopic Dermatitis and Systemic Infection
Yumi Matsuoka-Nakamura, MD/PhD, Professor, Cutaneous Allergy and Host Defense
Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Dr. Yumi Matsuoka-Nakamura is a Professor in Cutaneous Allergy and Host Defense
Immunology Frontier Research Center at Osaka University. Her lab aims to explore the roleof skin microbiome and pathogens in inflammatory skin diseases using omics approaches
and animal models. Her long-term research goal is to understand the molecular mechanisms
underlying the formation and regulation of cutaneous microbiome ecological system. She
earned her MD degree from University of Yamanashi, Japan in 2003 and PhD degree from
Chiba University, Japan in 2009. She received a postdoctoral training at University of Michigan
Medical School from 2009-2013. Since 2015, she has been a board-certified dermatologist
by The Japanese Dermatological Association. She was a recipient of 2020 LEO Foundation
Award – Region Asia-Pacific.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING79

ESDR Special Guest Lecture

Skin T cells in Lockdown – Regulation of Human T Cell Tissue Residency––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
13:15 – 13:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Curdin Conrad

Christina Zielinski, MD
Leibniz Institute for Natural Product Research and Infection Biology andthe Friedrich Schiller University, Jena, Germany

Christina Zielinski is the Chair of the Department of Infection
Immunology at the Leibniz Institute for Natural Product Research andInfection Biology and the Friedrich Schiller University in Jena. She
studied medicine at the University of Heidelberg (Germany), at Harvard
University (USA) and Duke University (USA). Her MD thesis research was
performed at Yale University as a scholar of the German National MeritFoundation where she focused on the role of T cells in the pathogenesisof lupus erythematosus.
Christina performed her postdoctoral training as a scholar of theGerman Research Foundation in the lab of Federica Sallusto in
Switzerland where she deciphered the regulatory cues that drive distinct
functionalities of human Th17 cells. She then started her own researchgroup as a Clinician Scientist at the Department of Dermatology at theCharité University Hospital in Berlin. Christina Zielinski also completed
her clinical specialization in dermatology and allergology at the
University of Tübingen and the Charité-University Medicine in Berlin.
In 2015, Christina was appointed professor at the German Center for
Infection Research at the Technical University of Munich.
Since 2021, she has been the Chair of Infection Immunology at the
Leibniz Institute for Natural Product Research and Infection Biology
and the Friedrich Schiller University in Jena, where she will continue towork on the regulation of human T cells and their translational impact inautoimmunity, infections, and cancer.

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Eli Lilly Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
13:50 - 15:20
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Explore Our Future from Investigative Research in Alopecia Areata,
Atopic Dermatitis and Psoriasis
CHAIRS:
Chris Griffiths, MD, Emeritus Professor of Dermatology, University of Manchester, Adjunct Professor,
King’s College London, Consultant Dermatologist, King’s College Hospital , United Kingdom
Manabu Ohyama, MD/PhD, Professor and Chairman, Department of Dermatology, Kyorin University
School of Medicine, Tokyo, Japan

Eli Lilly’s R&D strategy in Dermatology

Lotus Mallbris, MD/PhD, Senior Vice President, Immunology Development & Medical Affairs, Eli
Lilly and Company. In her current role, as the Senior Vice President, Immunology Developmentin the Lilly Immunology Business Unit, she leads a multifunctional team across dermatology,
rheumatology, gastroenterology field and COVID. She received her medical degree from Karolinska
Institute, Ph.D. and Post-Doctorate Diploma from Department of Medicine at Karolinska Institute,in Stockholm, Sweden and MBA from Stern NY University in collaboration with the London Schoolof Economics(UK) and HEC Paris School of Management (France). She continues to be an active
member of several external immunology research advisory boards focusing on bridging the external
state-of-the-art research with Lilly.
Latest Insights on the Pathogenesis and Treatment of Alopecia Areata
Ohsang Kwon, MD/PhD, Professor, Department of Dermatology, Seoul National University
Hospital, Seoul, Korea. Dr. Kwon received his medical degree from Seoul National University
College of Medicine in 1994 and Ph.D. degree from Graduate School, Seoul National University in
2005. He received Dermatology residency and fellowship training at the Seoul National University
Hospital. He clinically specializes in alopecia of both male and female, the scalp diseases, and hair
restoration surgery. His research interests are mechanism of alopecia and hair follicle regeneration.
He is conducting fundamental experiments in the field of stem cell biology and regeneration of hairfollicles and trying to develop new treatment for hair loss. He has actively participated in clinical
trials, including the landmark phase 3 clinical trials to validate the efficacy and safety of dutasteridein male pattern hair loss and JAK inhibitors in severe alopecia areata.
Unraveling the Heterogeneity of Atopic Dermatitis: “A Closer Look at Longitudinal Course”
Raj Chovatiya, MD/PhD, Assistant Professor, Dermatology at the Northwestern University Feinberg
School of Medicine, Chicago, USA. Dr. Chovatiya received his M.D. and Ph.D. in immunology fromYale University. Dr. Chovatiya is the medical director for the Clinical Trials Unit and leads the Center
for Eczema and Itch in the Department of Dermatology at Northwestern, and his clinical andresearch focus includes the intersection of cutaneous immunology and inflammatory disease. He
has a particular interest in optimizing patient-centered care, understanding chronic disease burden
especially in understudied inflammatory diseases, and improving care across diverse skin types. He
has published numerous abstracts and manuscripts and has been recognized for his contributions
as a speaker, researcher, and leader at national and international conferences.
RWE for Clinical Decision Making in Psoriasis
Andreas Pinter, MD/PhD, Director Clinical Research, Department of Dermatology, Venereology
and Allergology, University of Frankfurt, Frankfurt, Germany. Dr. Pinter holds a degree in medicine
from the University of Frankfurt. He has a strong focus on immune-mediated diseases andinterdisciplinary patient treatment. Dr. Pinter has been investigator and principal investigator in> 200 clinical trials and is an author of > 70 peer-reviewed publications. He is a frequent speaker atnational and international venues where he shares his broad clinical expertise.

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81

Concurrent Mini-Symposium 7

Adaptive and Auto-Immunity II
Studies of adaptive immune responses involving T and B lymphocytes, dendritic cells, other antigen presenting cells, and antigen
processing and presentation; Basic and pre-clinical experimental studies focused on autoimmunity.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Chih-Hung Lee, Dr. Michael Hertl, Dr. John Harris

16:20-16:30

ORAL 116 [POSTER 042]

The tumor microenvironment limits the development and persistenceof tissue-resident memory T cells
J. B. Williams, T. S. Kupper
Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts,
United States

T cell-derived lymphotoxin β receptor signaling forms HEV-likevessels in the skin of atopic dermatitis-like inflammation in mice
S. Kanameishi1, S. Ono1, Y. K. Honda1, 3, R. Asahina1, T. Honda2,
K. Kabashima1
1
Dermatology, Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu, Kyoto,
Kyoto, Japan, 2Dermatology, Hamamatsu Ika Daigaku, Hamamatsu,
Shizuoka, Japan, 3Immunology Division, Garvan Institute of Medical
Research, Sydney, New South Wales, Australia

15:40-15:50

16:30-16:40

15:30-15:40

ORAL 111 [POSTER 157]

ORAL 112 [POSTER 007]

Commensal papillomaviruses role in sun-damaged skin homeostasis
H. G. Son1, D. T. Ha1, R. Guennoun1, J. Strickley1, T. H. Erlich1,
D. E. Fisher1, J. Joh2, S. Demehri11
CBRC, Massachusetts General Hospital, Boston, Massachusetts, UnitedStates, 2University of Louisville, Louisville, Kentucky, United States

15:50-16:00

ORAL 113 [POSTER 143]

Genetic and transcriptional signatures of merkel cell
carcinoma-specific B cells suggest a functional role in modulating
cancer immunity
A. J. Remington1, 2, H. J. Rodriguez1, 2, T. Pulliam1, M. D. Gray2,
J. J. Taylor2, P. Nghiem1
1
Division of Dermatology, University of Washington, Seattle, Washington,
United States, 2Vaccine and Infectious Disease Divison, Fred Hutchinson
Cancer Center, Seattle, Washington, United States

16:00-16:10

ORAL 114 [POSTER 084]

Neoantigen-specific T cell responses constrain cutaneous squamouscell carcinoma
A. C. Adams1, A. M. Macy1, E. S. Borden1, L. M. Herrmann1,
K. H. Buetow2, M. A. Wilson2, D. J. Roe3, K. T. Hastings1
1
College of Medicine – Phoenix, University of Arizona, Phoenix, Arizona,
United States, 2School of Life Sciences, Arizona State University, Tempe,
Arizona, United States, 3Mel and Enid Zuckerman College of Public
Health, University of Arizona, Tucson, Arizona, United States

16:10-16:20

ORAL 117 [POSTER 055]

IL-15 contributes to atopic dermatitis pathogenesis: Lessons from anovel humanized mouse disease model
I. Piccini1, O. Egriboz1, K. I. Pappelbaum1, M. Fehrholz1, A. Keren2,
R. Paus1, 3, 5, A. Gilhar2, A. Vicari4, M. Bertolini1
1
Monasterium Laboratory GmbH, Münster, Germany, 2Technion Israel
Institute of Technology, Haifa, Israel, 3Dermatology, University ofMiami, Miami, Florida, United States, 4Calypso Biotech BV, Amsterdam,
Netherlands, 5CUTANEON, Hamburg, Germany

16:40-16:50

ORAL 118 [POSTER 167]

IL-36 axis is female-biased in pustular psoriasis in type I
IFN-dependent manner
M. Sarkar1, F. Ma2, 1, A. Kidder1, A. Coon1, B. E. Perez White3, R. Uppala1,
N. L. Ward4, C. Dobry1, L. Tsoi1, J. M. Kahlenberg2, J. Gudjonsson1
1
Dermatology, University of Michigan, Ann Arbor, Michigan, UnitedStates, 2Rheumatology, Internal Medicine, University of Michigan,
Ann Arbor, Michigan, United States, 3Dermatology, Northwestern
University Feinberg School of Medicine, Chicago, Illinois, UnitedStates, 4Dermatology, Vanderbilt University Medical Center, Nashville,
Tennessee, United States

16:50-17:00

ORAL 119 [POSTER 057]

Single-cell RNA sequencing reveals cellular drivers of UV-mediatedskin injury in cutaneous lupus
M. P. Maz, F. Ma, M. Gharaee-Kermani, A. Victory, A. Hurst,
J. Gudjonsson, J. M. Kahlenberg
University of Michigan, Ann Arbor, Michigan, United States

ORAL 115 [POSTER 150]

Single-cell RNA sequencing defines disease-specific differences
between prurigo nodularis and atopic dermatitis
N. Alkon1, F. P. Assen1, T. Arnoldner1, W. M. Bauer1, M. Medjimorec1, L.
Shaw1, K. Rindler1, G. Holzer2, P. Weber1, W. Weninger1, T. Kinaciyan1,
M. Farlik1, C. Jonak1, J. Griss1, C. Bangert1, P. Brunner3
1
Medizinische Universitat Wien, Wien, Austria, 2Klinik Donaustadt,
Vienna, Austria, 3Icahn School of Medicine at Mount Sinai, New York,New York, United States

17:00-17:10

ORAL 120 [POSTER 094]

Periostin – an inducer of pro-fibrotic phenotype in monocytes andmonocyte-derived macrophages in systemic sclerosis
M. Suzuki, Y. Ototake, A. Akita, M. Asami, N. Ikeda, Y. Yamaguchi
Yokohama Shiritsu Daigaku Igakubu Daigakuin Igaku Kenkyuka,
Yokohama, Kanagawa, Japan

Continued on next page.

82

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Concurrent Mini-Symposium 7 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
17:10-17:20

ORAL 121 [POSTER 128]

A stable, but reversible replicative arrest in alopecia areata
K. Meier1, 2, J. Brück2, T. Mehra3, M. Gassenmaier2, E. MüllerHermelink1, 2, A. Hossini4, C. C. Zouboulis4,
K. Ghoreschi1, 2,
M. Röcken2
1
Department of Dermatology, Venereology and Allergology, Charite
Universitatsmedizin Berlin, Berlin, Germany, 2Department of Dermatology,
Eberhard-Karls-Universitat Tubingen Medizinische Fakultat, Tubingen,Baden-Württemberg, Germany, 3Kantonsspital Baselland, Liestal,
Basel-Landschaft, Switzerland, 4Department of Dermatology,
Venereology, Allergology and Immunology, Stadtisches Klinikum
Dessau, Dessau, Sachsen-Anhalt, Germany

17:20-17:30

ORAL 122 [POSTER 169]

Vitiligo lesions are driven by the collaboration of expanded CD8+
T cell clones
E. Katz1, A. Manukyan1, K. Gellatly1, M. Wadsworth2, A. Winkler2,
W. Ruff3, M. Garber1, J. E. Harris1
1
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States, 2Pfizer Inc, New York, New York, UnitedStates, 3Repertoire, Cambridge, Massachusetts, United States

17:30-17:40

17:40-17:50

ORAL 124 [POSTER 095]

HLA class II-restricted CD8+ T cells contribute to the promiscuous
immune response in dapsone hypersensitive patients
Q. Zhao1, L. Sun1, H. Liu1, D. Naisbitt2, F. Zhang1
1
Shandong Provincial Hospital for Skin Diseases, Jinan, Shandong,
China, 2University of Liverpool, Liverpool, United Kingdom

17:50-18:00

ORAL 125 [POSTER 097]

VDAC as a novel actionable therapeutic target in pemphigus vulgaris
S. Assaf1, 2, O. Sarig1, C. Bilu1, Y. Zoabi2, K. Malovitski1, 2,
Y. Feller1, 2, S. Bergson1, 2, V. Shoshan-Barmatz3, N. Shomron2,
D. Vodo1, E. Sprecher1, 2
1
Tel Aviv Medical Center, Tel Aviv, Israel, 2Tel Aviv University Sackler
Faculty of Medicine, Tel Aviv, Israel, 3Ben-Gurion University of the Negev,
Beer-Sheva, Israel

ORAL 123 [POSTER 181]

The role of nuclear IL-37 in regulating FOXP3 expression and Treg
cell stability
D. Osborne1, J. Domenico1, P. K. Vaddi1, Z. Zhai1, C. Dinarello2, 3,
M. Fujita1, 3, 4
1
Dermatology, University of Colorado Anschutz Medical Campus, Aurora,
Colorado, United States, 2Medicine, University of Colorado Anschutz
Medical Campus, Aurora, Colorado, United States, 3Immunology &Microbiology, University of Colorado Anschutz Medical Campus, Aurora,
Colorado, United States, 4Veterans Affairs Medical Center, VA Eastern
Colorado Health Care System, Aurora, Colorado, United States

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83

Concurrent Mini-Symposium 8

Clinical Research: Epidemiology and Observational Research II
Non-interventional studies of populations or patient cohorts that evaluate, but are not limited to, the natural history of disease,disease burden, co-morbidities, health-related quality of life, and patient-reported outcomes research.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Dedee Murrell, Dr. Adela Rambi-Cardones, Dr. Jean Krutmann
15:30-15:40

ORAL 126 [POSTER 402]

Antihypertensive medication associated with eczematous dermatitis
in older adults
M. Ye1, I. Douglas2, S. Evans2, S. M. Langan2, K. Abuabara1
1
Department of Dermatology, University of California San Francisco,
San Francisco, California, United States, 2London School of Hygiene
and Tropical Medicine Faculty of Epidemiology and Population Health,London, London, United Kingdom

15:40-15:50

ORAL 127 [POSTER 488]

Dual blockade of IL-4 and IL-13 with dupilumab reduces severity oftype 2 inflammatory immune-related adverse events
C. Lee1, W. Chung2, C. Chen2
1
Department of Medical Education, Chang Gung Memorial Hospital,
Keelung, Taiwan, 2Drug Hypersensitivity Clinical and Research Center,
Department of Dermatology, Chang Gung Memorial Hospital, Linkou,
Taipei and Keelung, Taiwan

15:50-16:00

ORAL 128 [POSTER 550]

Atopic dermatitis in adolescents: Role of carbonyl reductase 3 genetic
risk score under constant chronic exposure to particulate matter
S. Kress1, M. Lau2, C. Wigmann1, F. Hartung1, T. Haarmann-Stemmann1,
T. Schikowski1
1
IUF Leibniz Research Institute for Environmental Medicine, Duesseldorf,
Germany, 2Heinrich-Heine-Universitat Dusseldorf, Dusseldorf, NordrheinWestfalen, Germany

16:00-16:10

ORAL 129 [POSTER 462]

Blood molecular phenotypes of Chinese AD patients
Y. Wang1, Y. Wu1, C. Gu1, X. Yao2, W. Li1
1
Department of Dermatology, Huashan Hospital Fudan University,
Shanghai, China, 2Department of Allergy and Rheumatology, AffiliatedHospital for Skin Diseases of Chinese Academy of Medical Sciences,
Nanjing, Jiangsu, China

16:10-16:20

ORAL 130 [POSTER 382]

A novel assessment of cardiovascular health in people with psoriasis
in the US: a cross-sectional study
S. Wang1, D. B. Shin1, T. Bhutani2, J. Gelfand1
1
Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania,
United States, 2Dermatology, University of California San Francisco, San
Francisco, California, United States

16:20-16:30

ORAL 131 [POSTER 484]

The relative abundance of unsaturated fatty acid and their dietary
habits in incident psoriatic diseases
Y. Xiao2, D. Jing2, S. Yang2, X. Chen2, M. Shen1
1
Department of Social Medicine and Health Management, Xiangya
School of Public Health, Central South University, Changsha, Hunan,
China, 2Dermatology, Central South University, Changsha, Hunan, China

16:30-16:40

ORAL 132 [POSTER 509]

IL-17A and IL-17F in the pathogenesis of hidradenitis suppurativa:
Insights from early and chronic lesions
A. Skelton1, H. Gopee2, R. Okoye1, A. Ferecsko1, M. Page1, S. Shaw1
1
UCB Pharma, Slough, United Kingdom, 2Newcastle University, Newcastle
upon Tyne, United Kingdom

16:40-16:50

ORAL 133 [POSTER 447]

Immunotherapy efficacy in Merkel cell carcinoma is affected by thepresence and type of immunosuppression: Analysis of 183 patients
E. Gong1, D. S. Hippe1, X. Fan1, L. Zawacki1, 2, A. J. Remington1,
A. Menon1, K. Lachance1, T. Akaike1, S. Park1, P. Nghiem1
1
University of Washington, Seattle, Washington, United States,
2
Washington State University, Pullman, Washington, United States

16:50-17:00

ORAL 134 [POSTER 430]

Merkel cell carcinoma and multiple primary cancers: A SEER-based
analysis
E. Eid1, N. Maloney2, Z. Ran Cai1, L. Zaba2, N. Kibbi2, E. M. John3,
E. Linos2
1
Program for Clinical Research and Technology, Stanford University,
Stanford, California, United States, 2Department of Dermatology,
Stanford University, Stanford, California, United States, 3Departmentof Epidemiology & Population Health, Stanford University, Stanford,
California, United States

17:00-17:10

ORAL 135 [POSTER 520]

A retrospective cohort study of patch testing in oral lichen planus andsubsequent diagnosis of oral squamous cell carcinoma
V. N. Sahni, Z. Hopkins, J. Rhoads, J. Clarke, C. Hansen, D. Powell, R.
deShazo, J. Zone, C. Hull
Dermatology, University of Utah Health, Salt Lake City, Utah, UnitedStatesContinued on next page.

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Concurrent Mini-Symposium 8 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
17:10-17:20

ORAL 136 [POSTER 508]

Prognostic relevance of blood T-cell clonality in mycosis fungoides
D. Joffe, L. Banner, L. Gleason, N. Nikbakht
Department of Dermatology and Cutaneous Biology, Thomas Jefferson
University, Philadelphia, Pennsylvania, United States

17:20-17:30

ORAL 137 [POSTER 410]

Clinicopathological factors and outcomes of cutaneous angiosarcoma
S. Yonekura, Y. Endo, K. Kabashima
Department of Dermatology, Kyoto University Graduate School of
Medicine, Kyoto, Japan

17:30-17:40

ORAL 138 [POSTER 571]

Associations among polymorphisms in FCγRIIIA and treatment
responses to rituximab in patients with pemphigus
P. Huang, Y. Cho, C. Chu
Department of Dermatology, National Taiwan University, Taipei, Taiwan

17:40-17:50

ORAL 139 [POSTER 522]

Serum levels of alarmins as potential biomarkers to diagnose andpredict activity/severity of non-segmental vitiligo
K. He1, W. Wu1, X. Wang1, W. Dai2, S. Wang2, C. Li1, S. Li1
1
Department of Dermatology, Xijing Hospital, Fourth Military Medical
University, Xi’an, China, Xi’an, Shaanxi, China, 2Department of
Dermatology and Venereology, Nanfang Hospital, Southern Medical
University, Guangzhou, China, Guangzhou, Guangdong, China

17:50-18:00

ORAL 140 [POSTER 445]

Higher ambient temperature contributes to extrinsic skin aging
N. Singh, S. Grether-Beck, T. Schikowski, J. Krutmann
IUF Leibniz Research Institute for Environmental Medicine, Duesseldorf,
Germany

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Concurrent Mini-Symposium 9

Innate Immunity, Microbiology, Microbiome I
Studies of cells, receptors and effector molecules of the innate immune response; studies on skin microbes, microbiome andinfectious processes of the skin.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Tatsuyoshi Kawamura, Dr. Heidi Kong, Dr. Anna Balato
15:30-15:40

ORAL 141 [POSTER 943]

Loss of both host-derived antimicrobial peptides and bacteriocinproducing commensals enables survival of Staphylococcus aureus
on Th2-inflamed skin
T. Nakatsuji, S. Brinton, K. Cavagnero, T. Dokoshi, A. O’Neill, R. L. Gallo
Dermatology, University of California San Diego, La Jolla, California,
United States

16:20-16:30

ORAL 146 [POSTER 963]

Linear ubiquitin chain assembly complex (LUBAC) is involved in thedevelopment of murine imiquimod (IMQ)-induced and IL-23-induced
psoriasis models
K. I. Kosaka1, S. Nakamizo1, G. Egawa1, K. Iwai2, K. Kabashima1
1
Departments of Dermatology, Kyoto University Graduate Schoolof Medicine, Kyoto, Japan, 2Department of Molecular and Cellular
Physiology, Kyoto University Graduate School of Medicine, Kyoto, Japan

16:30-16:40

ORAL 147 [POSTER 968]

Epicutaneous staphylococcus aureus exposure triggers lunginflammation via epithelia-intrinsic IL-36R signaling
S. Nolan, Y. Saito, D. Dikeman, C. Pontaza, M. Ahmadi, C. Youn, J.
Zhang, N. Archer
Dermatology, Johns Hopkins University School of Medicine, Baltimore,
Maryland, United States

A role for immunity to the microbiota in nerve overgrowth display inpsoriasis skin
J. Delaleu2, 1, M. Nagai1, L. Sun1, N. Bouladoux1, I. Gribonika1,
D. Corral1, A. Wells1, P. Kulalert1, V. Link1, M. Enamorado1, Y. Belkaid1
1
LHIM, National Institutes of Health, Bethesda, Maryland, United States,
2
Hopital Saint Louis, Dermatology Department, Universite Paris Cite,
Paris, Île-de-France, France

15:50-16:00

16:40-16:50

15:40-15:50

ORAL 142 [POSTER 950]

ORAL 143 [POSTER 933]

Staphylococcus aureus reversibly regulates Agr quorum sensing tocause an outbreak in a hospital
Y. Yamazaki1, H. Takahashi2, A. Takaya3, Y. Matsuoka-Nakamura1, 4,
M. Fujimoto1
1
Dermatology, Graduate School of Medicine, Osaka University, Suita,
Japan, 2Medical Mycology Research Center, Chiba, Japan, 3Natural
Products Chemistry, Graduate School of Pharmaceutical Sciences,
Chiba University, Chiba, Japan, 4Cutaneous Allergy and Host Defense,
Immunology Frontier Research Center, Suita, Japan

16:00-16:10

ORAL 144 [POSTER 906]

A novel IL-31-generating mechanism in atopic dermatitis: essential
roles of macrophages in cooperation with basophils, thymic stromal
lymphopoietin and periostin
T. Hashimoto, T. Satoh
Dermatology, Boei Ika Daigakko, Tokorozawa, Saitama, Japan

16:10-16:20

ORAL 145 [POSTER 974]

Decreased epidermal thickening by imiquimod in mice withconditional aryl hydrocarbon receptor ablation in langerhans cells:
A potential role of autophagy by dysregulated AhR activation inpsoriasis
C. Hong1, C. Lee2
1
Dermatology, National Yang Ming Chiao Tung University, Taipei, Taiwan,
2
Dermatology, Chang Gung Memorial Hospital Kaohsiung Branch,
Kaohsiung, Taiwan

ORAL 148 [POSTER 958]

Diversely polarized macrophage populations contribute to distinct
manifestations of human cutaneous graft-versus-host disease
J. Strobl1, 2, 3, L. Gail3, 1, L. Krecu1, S. Mahdad2, L. Kleissl1, P. Wohlfarth4,
H. Knaus4, W. Rabitsch4, M. Haniffa2, 5, G. Stary1, 3
1
Department of Dermatology, Medizinische Universitat Wien, Wien,
Austria, 2Wellcome Sanger Institute, Hinxton, Cambridgeshire, United
Kingdom, 3CeMM Research Center for Molecular Medicine of theAustrian Academy of Sciences, Vienna, Austria, 4Bone Marrow
Transplantation, Medizinische Universitat Wien Universitatsklinik
fur Innere Medizin I, Wien, Austria, 5Department of Dermatology and
NIHR Newcastle Biomedical Research Centre, Newcastle University,
Newcastle upon Tyne, Tyne and Wear, United Kingdom

16:50-17:00

ORAL 149 [POSTER 1005]

Low levels of IL-13 are constitutively produced in healthy skin andlocally imprint a pro-type 2 immune response
J. Mayer1, 2, K. Hilligan2, 4, D. Eccles2, S. Old2, R. Domingues3,
M. Hepworth3, O. Lamiable2, F. Ronchese2
1
Department of Dermatology and Allergology, Philipps-Universitat
Marburg Fachbereich Medizin, Marburg, Germany, 2Malaghan Instituteof Medical Research, Wellington, New Zealand, 3The University ofManchester, Manchester, United Kingdom, 4National Institutes of Health,Bethesda, Maryland, United States

Continued on next page.

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Concurrent Mini-Symposium 9 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
17:00-17:10

ORAL 150 [POSTER 925]

Peripheral sensory neurons contribute to dermatitis induced bystaphylococcus aureus cell wall components via the migration ofbasophils
H. Irie1, C. Nakashima2, A. Otsuka2, Y. Ishida1, K. Kabashima1
1
Dermatology, Kyoto University Graduate School of Medicine, Kyoto,
Kyoto, Japan, 2Dermatology, Kindai University Faculty of Medicine,
Osaka-Sayama, Osaka, Japan

17:10-17:20

ORAL 154 [POSTER 937]

Disruption of the innate lymphoid cell network alters the hair cycle
during induced anagen
K. Sakamoto1, 2, O. Ayush1, S. Jin3, 1, S. Goel1, A. Sekiguchi1, T. Honda2,
K. Nagao1
1
Dermatology Branch, NIAMS, National Institutes of Health, Bethesda,
Maryland, United States, 2Dermatology, Hamamatsu Ika Daigaku,
Hamamatsu, Shizuoka, Japan, 3Dermatology, Seoul National University,
Gwanak-gu, Seoul, Korea (the Republic of)

ORAL 151 [POSTER 948]

The topical TLR8 agonist resiquimod restores defective nucleotide
sensing in CTCL
C. Chen1, N. Smith2, C. Villani2, P. Chaskar3, J. Krishnaswamy3,
J. Teague1, A. Gehad1, L. Gray1, N. Gerard1, A. Rook4, R. Clark1
1
Brigham and Women’s Hospital, Boston, Massachusetts, UnitedStates, 2Massachusetts General Hospital, Boston, Massachusetts,
United States, 3Galderma SA, Lausanne, Switzerland, 4University ofPennsylvania, Philadelphia, Pennsylvania, United States

17:20-17:30

17:40-17:50

17:50-18:00

ORAL 155 [POSTER 975]

Skin inflammation disrupts intestinal antimicrobial activity and thegut microbiome
T. Dokoshi1, G. Rahman1, K. Cavagnero1, S. Brinton1, H. Schwarz1,
Y. Nakamura1, Y. Chen1, N. Salzman2, R. Knight1, R. L. Gallo1
1
University of California San Diego, La Jolla, California, United States,2
Medical College of Wisconsin, Milwaukee, Wisconsin, United States

ORAL 152 [POSTER 1028]

Cathelicidin peptide LL37 complexed to dsRNA induces the release ofinterleukin-36γ from human primary keratinocytes
J. Keller1, 4, J. Danis2, E. Girousi1, 4, J. Börold1, 4, M. Szell2, L. E. French3,
T. M. Kündig1, 4, M. Mellett1, 41
Dermatology,
UniversitatsSpital
Zurich,Zurich,Switzerland,2
Dermatological Research Group, Szegedi Tudomanyegyetem, Szeged,
Csongrád, Hungary, 3Dermatology, Ludwig-Maximilians-Universitat
Munchen Medizinische Fakultat, Munchen, Bayern, Germany, 4Universitat
Zurich Medizinische Fakultat, Zurich, ZH, Switzerland

17:30-17:40

ORAL 153 [POSTER 980]

Demodex mites reveal an unanticipated expansion of innate
lymphoid-like cells in immunodeficient mice
E. Arouge1, A. Subramanian1, A. Schroeder2, V. Cortez2, C. O’Leary3,
R. R. Ricardo-Gonzalez1, 4, 5
1
Dermatology, University of California San Francisco, San Francisco,California, United States, 2University of California San Francisco
Department of Medicine, San Francisco, California, United States,
3
Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin,
United States, 4Microbiology and Immunology, University of California
San Francisco, San Francisco, California, United States, 5Chan
Zuckerberg Biohub, San Francisco, California, United States

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Concurrent Mini-Symposium 10

Pharmacology and Drug Development
Basic and preclinical studies aimed at developing therapeutics, elucidating their mechanisms of action, and identifying biomarkers
of drug activity.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Riichiro Abe, Dr. Brian Capell, Dr. Su Lwin

15:30-15:40

16:20-16:30

ORAL 156 [POSTER 1064]

Desmoglein 2 is a safe and universal CAR-T cell therapy target insolid cancers
R. D. Carlson1, S. A. Waldman1, M. G. Mahoney2, A. E. Snook1
1
Department of Pharmacology, Physiology, and Cancer Biology,
Thomas Jefferson University, Philadelphia, Pennsylvania, United States,
2Dermatology & Cutaneous Biology, Thomas Jefferson University,
Philadelphia, Pennsylvania, United States

15:40-15:50

ORAL 157 [POSTER 1109]

First-in-class oral peptide systemically targeting the IL-23 pathway
A. Fourie1, X. Cheng2, L. Chang1, C. Greving1, A. Patrick1,
B. Knight1, D. Polidori1, R. Patch1, A. Bhandari2, D. Liu2, K. Huie2, S. Li2,
M. Rodriguez1, A. Kannan1, J. Sherlock1, N. Modi2
1
Janssen Research and Development LLC, Raritan, New Jersey, UnitedStates, 2Protagonist Therapeutics Inc, Newark, California, United States

15:50-16:00

ORAL 158 [POSTER 1060]

IMG-008, a potent anti-human IL-36R antagonistic antibody, inhibits
IL-36R-mediated inflammation
R. Lei1, P. Fan1, M. Zhang1, Y. Wang1, C. Guo1, J. Wang2
1
Inmagene Biopharmaceuticals (Hangzhou) Co., Ltd., Hangzhou,
Zhejiang, China, 2Inmagene LLC, San Diego, California, United States

16:30-16:40

ORAL 159 [POSTER 1065]

The topical AhR agonist tapinarof has broad in vivo
immunosuppressive and immunomodulatory effects in humanskin grafted mice
G. Brito, A. Gehad, J. Teague, C. Chen, W. Crisler, L. Gray, I. Kim,
R. Clark
Brigham and Women’s Hospital, Boston, Massachusetts, United States

16:10-16:20

ORAL 162 [POSTER 1111]

Topical γ-linolenic acid restores skin barrier dysfunction andameliorates atopic dermatitis in hairless mice
M. Fujii1, S. Ohya1, 2, T. Nabe1, 3
1Pharmacology, Kyoto Yakka Daigaku, Kyoto, Japan, 2Pharmacology,
Nagoya Shiritsu Daigaku, Nagoya, Aichi, Japan, 3Immunopharmacology,
Setsunan Daigaku, Neyagawa, Osaka, Japan

16:40-16:50

ORAL 163 [POSTER 1101]

Tapinarof, a therapeutic AHR-modulating agent, induces semaphorin
3A production via NRF2 in human keratinocytes: Implications foratopic dermatitis
G. Tsuji1, A. Takai-Yumine1, M. Takemura1, K. Yamamura1, T. Ito2,
M. Kido-Nakahara2, T. Nakahara1, 2
1
Research and Clinical Center for Yusho and Dioxin, Kyushu Daigaku
Byoin, Fukuoka, Japan, 2Dermatology, Kyushu Daigaku Igakubu
Daigakuin Igakukei Gakufu Daigakuin Igaku Kenkyuin, Fukuoka, Japan

16:50-17:00
16:00-16:10

ORAL 161 [POSTER 1104]

Novel and selective TRPV3 inhibitors as new potential treatments for
keratodermas and itch
E. Brener1, T. Mashriki1, M. McGrath2, L. Marchal2, E. Ella1,
M. Moran1, S. Leibman Barak1, B. Vaisman1, D. Terkieltaub1, N. Schutz1,
A. Hovnanian2, L. Braiman1
1
Kamari Pharma Ltd., Ness Ziona, Israel, 2Institut Imagine Institut desMaladies Genetiques, Paris, Île-de-France, France

ORAL 164 [POSTER 1099]

Rational development of JAK1-selective siRNA therapeutics for thetreatment of autoimmune skin diseases
Q. Tang1, 2, H. Fakih2, M. Zain Ul Abideen2, K. Afshari1, K. Gross2,
J. Alterman2, A. Khvorova2, J. E. Harris1
1
Dermatology, University of Massachusetts Chan Medical School,
Worcester, Massachusetts, United States, 2RNA Therapeutics Institute,
University of Massachusetts Chan Medical School, Worcester,
Massachusetts, United States

ORAL 160 [POSTER 1075]

Topical application of activator protein-1 inhibitor T-5224 suppresses
inflammation and improves skin barrier function in atopic dermatitis
M. Sasakura1, H. Urakami1, K. Tachibana1, K. Ikeda1, D. Ennishi2,
S. Tomida2, S. Morizane1
1
Department of Dermatology, Okayama Daigaku Daigakuin Ishiyakugaku
Sogo Kenkyuka, Okayama, Japan, 2Center for Comprehensive Genomic
Medicine, Okayama Daigaku Byoin, Okayama, Japan

17:00-17:10

ORAL 165 [POSTER 1078]

Topical administration of MDI1228, a novel pan-JAK inhibitor,
effectively suppresses the development of skin inflammation in mice
Y. Liu, M. Yin, Y. Yang, L. Zhang
School of Pharmaceutical Science, Xiamen University, Xiamen, Fujian,
China

Continued on next page.

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1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 10 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
17:10-17:20

ORAL 166 [POSTER 1116]

Novel androgen receptor degrader for androgenetic alopecia (AGA)
application
C. Chou, C. Liu, P. Liu, P. Cheng, H. Chen, K. Chen, C. Lin
AnHorn Medicines Co., Ltd., Taipei, Taiwan

17:20-17:30

ORAL 167 [POSTER 1069]

Fate induction in CD8 chimeric antigen receptor T cells throughasymmetric cell division
C. Ellebrecht1, 2, C. Lee1, 2, A. R. Kelly2, 3, C. Berry1, 2, S. Oh1, 2,
R. O’Connor2, 3, A. Payne1, 2
1
Department of Dermatology, University of Pennsylvania Perelman
School of Medicine, Philadelphia, Pennsylvania, United States, 2Center for
Cellular Immunotherapies, University of Pennsylvania Perelman Schoolof Medicine, Philadelphia, Pennsylvania, United States, 3Departmentof Pathology and Laboratory Medicine, University of Pennsylvania
Perelman School of Medicine, Philadelphia, Pennsylvania, United States

17:30-17:40

17:50-18:00

ORAL 170 [POSTER 1098]

Anti-inflammatory and antibacterial drug delivery nanocarriers
for the topical treatment of MRSA-induced systemic and localized
infections
Y. Chang1, C. Lin1, T. Huang1, 2, 3, J. Fang1, 2, 3
1
Graduate Institute of Natural Products, Chang Gung University, Taoyuan,
Taiwan, 2Department of Anesthesiology, Chang Gung Memorial Hospital
Linkou, Taoyuan, Taiwan, 3Research Center for Food and Cosmetic
Safety and Research Center for Chinese Herbal Medicine, Chang Gung
University of Science and Technology, Gueishan, Taoyuan, Taiwan

ORAL 168 [POSTER 1126]

A pilot of a microdevice for in situ candidate drug screening in
cutaneous lesions of T-cell lymphoma
K. Awh1, 2, C. J. Fay1, 2, N. LeBoeuf1, 2, O. Jonas3, C. Larocca1, 2
1Brigham and Women’s Hospital Department of Dermatology, Boston,
Massachusetts, United States, 2Cutaneous Oncology, Dana-Farber
Cancer Institute, Boston, Massachusetts, United States, 3Brigham and
Women’s Hospital Department of Radiology, Boston, Massachusetts,
United States

17:40-17:50

ORAL 169 [POSTER 1089]

Targeting right open reading frame protein kinase 3 (RIOK3) for themodulation of type III IFN in skin
M. Diaz1, M. Diaz1, J. Kreitinger1, T. C. Bisom2, J. Lodmell3, P. Diaz1, 41
DermaXon, Missoula, Montana, United States, 2Dept. of Chemistry
and Biochemistry, University of Montana College of Humanities andSciences, Missoula, Montana, United States, 3Division of Biological
Sciences, University of Montana College of Humanities and Sciences,
Missoula, Montana, United States, 4Department of Biomedical andPharmaceutical Sciences, University of Montana College of Health,
Missoula, Montana, United States

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Concurrent Mini-Symposium 11

Photobiology/Skin of ColorStudies on biological, biochemical, and molecular responses to ultraviolet radiation in cells, animals and humans/Studies of thepathogenesis or treatment of skin diseases that disproportionately affect patients from, or are more severe in their manifestationin, racial/ethnic groups with skin of color, such as keloids, scarring alopecias, disorders of pigmentation, systemic lupus
erythematosus, dermatomyositis, among others.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Hee Young Kang, Dr. Raymond Konger, Dr. Andrea Szegedi
15:30-15:40

ORAL 171 [POSTER 1161]

UV irradiation modulates appetite and body weight throughupregulating norepinephrine in mice
Q. Quan1, 2, 3, E. Kim1, 2, 3, Y. Kim1, 2, 3, S. Kim1, 2, 3, M. Chung1, 2, 3,
Y. Tian1, 2, 3, C. Shin1, 2, 3, D. Lee1, 2, 3, J. Chung1, 2, 3
1
Dermatology, Seoul National University College of Medicine, Seoul,
Korea (the Republic of), 2Laboratory of Cutaneous Aging Research,
Biomedical Research Institute, Seoul National University Hospital, Seoul,
Korea (the Republic of), 3Institute of Human-Environment Interface
Biology, Seoul National University, Seoul, Korea (the Republic of)

15:40-15:50

ORAL 172 [POSTER 1163]

Skin commensal bacteria modulate ultraviolet radiation-induced
cytokine secretion in human keratinocytes
H. Serrage1, M. Farrar1, A. J. Mcbain1, J. Pennock1, C. Deng1,
C. O’Neill1, 2
1
The University of Manchester, Manchester, United Kingdom, 2Skin
BioTherapeutics PLC, Newcastle, United Kingdom

15:50-16:00

ORAL 173 [POSTER 1146]

Mitochondrial dysfunction in xeroderma pigmentosum type A (XPA)
causes UV-induced collapse of proteostasis due to lack of ATP
M. Majora, R. Bhattacharjee, S. Dangeleit, A. Rossi, J. Krutmann
IUF – Leibniz Research Institute for Environmental Medicine, Düsseldorf,
Germany

16:00-16:10

ORAL 174 [POSTER 1136]

Xeroderma Pigmentosum: From disease modeling using CRISPRCas9 technology to the understanding of skin cancers pathophysiology
A. Nasrallah1, F. Kobaisi1, S. Bourgoin-Voillard2, F. Clement1, X. Gidrol1,
M. Seve2, E. Sulpice1, W. Rachidi1
1Univ. Grenoble Alpes, CEA, INSERM, 38000 Grenoble, France, Grenoble,
France, 2Univ. Grenoble Alpes, CNRS, TIMC U5525, EPSP 38000 Grenoble,
France, Grenoble, France

16:10-16:20

ORAL 175 [POSTER 1145]

Evidence that microvesicle particles mediate the photosensitivity
associated with xeroderma pigmentosum A deficiency
P. Manjrekar, L. R. Christian, C. Rapp, K. M. Henkels, R. Annamraju,
Y. Chen, J. Travers
Pharmacology & Toxicology, Wright State University Boonshoft Schoolof Medicine, Dayton, Ohio,
United States

16:20-16:30

ORAL 176 [POSTER 1166]

Kinome siRNA screening for the treatment of the XPC cancer-pronediseaseF. Kobaisi1, E. Sulpice2, A. Nasrallah1, X. Gidrol2, W. Rachidi1
1
Universite Grenoble Alpes, Saint-Martin-d’Heres, Auvergne-RhôneAlpes , France, 2IRIG, Commissariat a l’energie atomique et aux energies
alternatives Siege administratif, Grenoble, France

16:30-16:40

ORAL 177 [POSTER 1168]

Neutrophil cytokines and NETs mediate skin and kidney inflammationin lupus flare under UVB irradiation
X. Lyu1, M. Li1, P. Zhang2, W. Wei1, V. P. Werth3, M. Liu3
1
Tianjin Medical University, Tianjin, China, 2Beaumont Health, Royaloak, Michigan, United States, 3University of Pennsylvania, Philadelphia,
Pennsylvania, United States

16:40-16:50

ORAL 178 [POSTER 1156]

Single-cell RNA sequencing of photoaged skin reveals SLC46A2 as
potential cGAMP transporter in keratinocytes
D. J. Kim1, A. Billi3, A. Chien2, G. J. Fisher3, J. J. Voorhees3,
J. Gudjonsson3, S. Kang2
1
Yale School of Medicine, New Haven, Connecticut, United States, 2Johns
Hopkins Medicine, Baltimore, Maryland, United States, 3University ofMichigan, Ann Arbor, Michigan, United States

16:50-17:00

ORAL 179 [POSTER 1291]

Tralokinumab improves signs, symptoms, and key biomarkers inpatients of different racial subgroups with atopic dermatitis
A. Alexis1, A. Blauvelt2, A. Armstrong3, L. Kircik4, K. Kabashima5,
N. Katoh6, B. Esdaile7, M. Røpke8, A. Kurbasic8, S. Schneider9,E. Guttman-Yassky4
1
Weill Cornell Medicine, New York, New York, United States, 2Oregon
Medical Research Center, Portland, Oregon, United States, 3University ofSouthern California Keck School of Medicine, Los Angeles, California,
United States, 4Icahn School of Medicine at Mount Sinai, New York, New
York, United States, 5Graduate School of Medicine, Kyoto University,
Kyoto, Japan, 6Kyoto Prefectural University of Medicine Graduate Schoolof Medical Science, Kyoto, Japan, 7Whittington Health NHS Trust,
London, United Kingdom, 8LEO Pharma A/S, Ballerup, Hovedstaden,
Denmark, 9LEO Pharma Inc, Madison, New Jersey, United States

17:00-17:10

ORAL 180 [POSTER 1301]

Polyamines: Novel regulators of human epidermal pigmentation
A. Sridharan1, Z. Lim1, K. Igarashi4, A. N. Tan3, S. T. Thng2, L. A. Vardy1
1
Agency for Science Technology and Research, Singapore, Singapore,
2
National Skin Centre, Singapore, Singapore, 3Nanyang Technological
University, Singapore, Singapore, 4Chiba Daigaku Daigakuin Igaku
Kenkyuin Igakubu, Chiba, Japan

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Concurrent Mini-Symposium 11 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
17:10-17:20

ORAL 181 [POSTER 1305]

Involucrin/ck1e/vitamin D receptor regulatory axis underlies
evolution of human epidermis out of Africa
A. R. Hicks1, 2, A. D. Schmidt3, M. Mathyer3, C. de Guzman Strong1, 2, 3
1
Dermatology, Henry Ford Health System, Detroit, Michigan, UnitedStates, 2Medicine, Michigan State University College of Human Medicine,
East Lansing, Michigan, United States, 3Medicine, Washington University
in St Louis School of Medicine, St Louis, Missouri, United States

17:20-17:30

ORAL 182 [POSTER 1318]

Racial differences in the skin microbiome of cutaneous T cell
lymphoma patients
L. Ayanruoh1, M. J. Hooper1, T. Griffin1, G. Enriquez2, J. Choi1,
J. Guitart1, M. Burns2, X. Zhou1
1
Dermatology, Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States, 2Biology, Loyola University Chicago,
Chicago, Illinois, United States

17:30-17:40

ORAL 183 [POSTER 1320]

Keloid transcriptome analysis: ZNF469 more than meets the eye
S. Hamzehlou1, C. Xing2, D. Glass1, 2
1
Dermatology, The University of Texas Southwestern Medical Center,
Dallas, Texas, United States, 2McDermott Center for Human Growth andDevelopment, The University of Texas Southwestern Medical Center,
Dallas, Texas, United States

17:40-17:50

ORAL 184 [POSTER 1294]

Proteomic profiling of CCCA reveals unique inflammatory andmetabolic protein signature
A. Gadre1, T. Dyson2, C. Aguh1
1
Dept of Dermatology, Johns Hopkins Medicine, Baltimore, Maryland,
United States, 2Eastern Virginia Medical School, Norfolk, Virginia, UnitedStates

17:50-18:00

ORAL 185 [POSTER 1312]

Heterogeneities in proteomic profiles among African American andEast African patients with atopic dermatitis
D. Liu1, E. Del Duca1, Y. Renert-Yuval2, C. Lang3, H. Kaderbhai4,
G. Semango4, M. Brüggen3, J. Krueger2, J. Masenga4,
E. Guttman-Yassky1
1
Dermatology, Icahn School of Medicine at Mount Sinai, New York,New York, United States, 2Laboratory of Investigative Dermatology, The
Rockefeller University, New York, New York, United States, 3Dermatology,
UniversitatsSpital Zurich, Zurich, Switzerland, 4Dermatology, Regional
Dermatology Training Centre, Moshi, Tanzania, United Republic of

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Concurrent Mini-Symposium 12Skin, Appendages, and Stem Cell Biology
Studies on the hair follicle, sebaceous gland, and other skin appendages; developmental biology of skin and hair; roles of stem cells
in pre and post-natal growth and development.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM G: TAKAO, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Ohsang Kwon, Dr. Sunny Wong, Dr. Carien Niessen

15:30-15:40

ORAL 186 [POSTER 1390]

Active hair growth is fuelled by conveyor-belt like differentiation ofgerminative layer cells
K. Annusver1, D. Pereira2, D. Fernandex1, B. Robert3, J. Nicolas3,
M. Kasper1, I. Sequeira2
1
Department of Cell and Molecular Biology, Karolinska Institutet,
Stockholm, Sweden, 2Queen Mary University of London Barts and The
London School of Medicine and Dentistry, London, United Kingdom,3
Institut Pasteur, Paris, Île-de-France, France

15:40-15:50

ORAL 187 [POSTER 1322]

A non-cell autonomous dermal hedgehog signaling mechanism forfollicular neoplasia and induction.
S. Li1, 2, A. Shah2, E. Sanchez-Ortiz2, N. Liu2, E. Olson2
1
Dermatology, Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States, 2Molecular Biology, The University ofTexas Southwestern Medical Center, Dallas, Texas, United States

15:50-16:00

ORAL 188 [POSTER 1401]

ΔNp63 regulates homeostasis, stemness, and suppression of
inflammation in the adult epidermis
C. Eyermann1, X. Chen1, O. Somuncu1, A. Joukov2, J. Chen1,
E. Alexandrova1
1
Stony Brook University, Stony Brook, New York, United States, 2Ward
Melville High School, East Setauket, New York, United States

16:00-16:10

ORAL 189 [POSTER 1439]

Development of a complex skin organ in human induced pluripotent
stem cell-derived organoids
A. Shafiee1, 2, 3, J. Sun1, I. Ahmed1, J. Brown2, 3, K. Khosrotehrani1
1
The University of Queensland, Brisbane, Queensland, Australia, 2Herston
Biofabrication Institute, Metro North Hospital and Health Service,
Brisbane, Queensland, Australia, 3Royal Brisbane and Women’s Hospital,
Metro North Hospital and Health Service, Brisbane, Queensland,
Australia

16:10-16:20

ORAL 190 [POSTER 1426]

Deletion of hoxc13 in frogs reveals key steps in the molecular
evolution of cornified skin appendages
A. P. Sachslehner1, M. Carron2, 3, S. Demuynck2, E. De Baere3,
K. Vleminckx2, L. Eckhart1
1
Department of Dermatology, Medical University of Vienna, Vienna,
Austria, 2Department of Biomedical Molecular Biology, Ghent University,
Ghent, Belgium, 3Department of Biomolecular Medicine, Ghent University,
Ghent, Belgium

16:20-16:30

ORAL 191 [POSTER 1397]

LSD1 is critical for epidermal development and skin barrier formation
N. Kuprasertkul, S. Egolf, C. Magahis, C. D’souza, J. Zou, D. BrennanCrispi, B. C. Capell
University of Pennsylvania Perelman School of Medicine, Philadelphia,
Pennsylvania, United States

16:30-16:40

ORAL 192 [POSTER 1438]

KLF4 maintains hair follicle stem cell quiescence
M. Xu1, D. Moran2, K. M. Szigety2, X. Zhu1, S. Millar1
1
Department of Cell, Developmental and Regenerative Biology, Icahn
School of Medicine at Mount Sinai Black Family Stem Cell Institute, New
York, New York, United States, 2Department of Dermatology, University ofPennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania,
United States

16:40-16:50

ORAL 193 [POSTER 1418]

Characterization of ectomesenchyme as an origin of epidermal
stem cells
A. Miura1, Y. Kobayashi1, Y. Hirose1, A. Yamanishi1, Y. Ouchi2,
R. Yamamoto2, T. Kitayama2, E. Takaki2, T. Shimbo2, K. Tamai1
1Stem Cell Therapy Science, Osaka University Graduate School of
Medicine, Suita-city, Osaka, Japan, 2StemRIM Institute of RegenerationInducing Medicine, Osaka University, Suita-city, Osaka, Japan

16:50-17:00

ORAL 194 [POSTER 1376]

A multi-scale spatial atlas of human skin links cancer cell states tosite of origin
C. Ganier1, B. Du-Harpur1, G. Herrera-Oropeza8, P. Mazin2, A. Predeus2,
J. Gabriel1, N. Harun1, M. Blakeley1, J. Darrigrand1, A. Haiser1,
S. Wyles3, T. J. Shaw4, S. Teichmann2, M. Haniffa2, 5, F. M. Watt1, 6,
M. Lynch1, 7
1Centre for Gene Therapy and Regenerative Medecine, Guy’s Hospital,
King’s College London Faculty of Life Sciences and Medicine, London,
United Kingdom, 2Wellcome Sanger Institute, Hinxton, Cambridgeshire,
United Kingdom, 3Department of Dermatology, Mayo Clinic Minnesota,
Rochester, Minnesota, United States, 4Centre for Inflammation Biology &Cancer Immunology, King’s College London School of Medical Education,
London, United Kingdom, 5Department of Dermatology, Newcastle Upon
Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United
Kingdom, 6Gesellschaft zur Forderung der Lebenswissenschaften
Heidelberg GmbH, Heidelberg, Baden-Württemberg, Germany, 7St John’s
Institute of Dermatology, King’s College London Faculty of Life Sciences
and Medicine, London, United Kingdom, 8King’s College London Instituteof Psychiatry Psychology and Neuroscience, London, United Kingdom

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Concurrent Mini-Symposium 12 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
15:30 – 18:00
ROOM G: TAKAO, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
17:00-17:10

ORAL 195 [POSTER 1352]

Ectopic fibroblasts to modify skin identity
S. S. Lee1, P. Derr2, E. Dare1, E. Sweren1, K. Derr2, B. Hardesty1,
C. Wang1, A. Willis1, J. Chen3, J. Vuillier1, J. Du1, M. Daskam1, J. Wool1,
A. Ruci1, V. . Wang1, C. Lee1, S. Iyengar1, D. Cho1, E. Martinez-Pena1,
S. Lee1, X. He1, S. Kim1, Y. Chen3, S. Kang1, L. A. Garza1
1
Dermatology, Johns Hopkins Medicine, Baltimore, Maryland, UnitedStates, 2National Center for Advancing Translational Sciences, Rockville,
Maryland, United States, 3Johns Hopkins University Whiting School ofEngineering, Baltimore, Maryland, United States

17:10-17:20

17:50-18:00

ORAL 200 [POSTER 1356]

Wound memory predisposes to tumorigenesis
M. Watanabe1, 2, 5, C. Levralevron1, 2, V. Proserpio1, 2, 3, G. Piacenti1, 2,
A. Lauria1, 2, 3, S. Kaltenbach4, A. Tamburrini1, 2, 3, K. Natsuga5, T. Hagai4,
S. Oliviero1, 2, 3, G. Donati1, 2
1Life Sciences and Systems Biology, Universita degli Studi di Torino,
Torino, Piemonte, Italy, 2Molecular Biotechnology Center, Universita
degli Studi di Torino, Torino, Piemonte, Italy, 3Italian Institute for
Genomic Medicine, Torino, Piemonte, Italy, 4George S Wise Faculty ofLife Sciences, Tel Aviv University The Shmunis School of Biomedicine
and Cancer Research, Tel Aviv, Israel, 5Dermatology, Hokkaido Daigaku
Daigakuin Igaku Kenkyuin, Sapporo, Hokkaido, Japan

ORAL 196 [POSTER 1381]

Investigating the role of Mef2c in hair follicle cycling
T. Tien1, 3, N. Pantelireis1, 2, C. Higgins2, C. Clavel1, 3
1
A*STAR Skin Research Labs, Agency for Science Technology andResearch, Singapore, Singapore, 2Imperial College London Departmentof Bioengineering, London, London, United Kingdom, 3Lee Kong Chian
School of Medicine, Singapore, Singapore

17:20-17:30

ORAL 197 [POSTER 1443]

Skin regional specificity and the regulation of HoxC gene cluster
S. Hsieh Li1, 2, Y. Liang1, R. Widelitz1, L. Andersson3, P. Wu1,
C. Chuong1
1
Pathology, University of Southern California, Los Angeles, California,
United States, 2Biochemistry, National Defense Medical Center, Taipei,
Taiwan, 3Medical Biochemistry and Microbiology, Uppsala universitet
Medicinska fakulteten, Uppsala, Sweden

17:30-17:40

ORAL 198 [POSTER 1360]

Fate tracing of DNA-damaged hair follicle stem cells and their senodifferentiation clearance out of the niche
M. Miranda, H. Matsumura, K. Asakawa, T. Kato, Y. Muroyama,
M. Higa, L. Tan, Y. Kawamura, E. K. Nishimura
Division of Aging and Regeneration, Institute of Medical Science,
The University of Tokyo, Tokyo, Japan

17:40-17:50

ORAL 199 [POSTER 1383]

Dermal adipogenesis is regulated by an interplay between the WNTβ-catenin and IL1 signaling pathways during skin development andregeneration
X. Zhang3, L. Sun3, S. Wu3, W. Liu3, Y. Liu3, F. Li1, Q. Yao3, J. Li3,
J. Huang2, C. Ji2, R. L. Gallo1, L. Zhang3
1
Department of Dermatology, University of California San Diego, La Jolla,
California, United States, 2Department of Dermatology, First AffiliatedHospital of Fujian Medical University, Fuzhou, Fujian, China, 3StateKey Laboratory of Cellular Stress Biology, School of Pharmaceutical
Sciences, Xiamen University, Xiamen, Fujian, China

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

93

Select ePoster Discussions, Session 2

Artificial Intelligence (AI) and Image Analysis/Translational Studies/
Pigmentation & Melanoma
Use of artificial intelligence and machine learning in healthcare; Technologies used for medical imaging and diagnostics/Studies that translate basic
research findings into human model systems (i.e. human tissue and/or cells) or humans/Studies on all aspects of cutaneous and extracutaneous
pigmentation; molecular cellular and biological facets of melanomama––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #1––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Kazutoshi Harada, Dr. Jeffrey Cheng

University Medical Center, Hackensack, New Jersey, United States,
3
BlueRock Therapeutics LLC, Cambridge, Massachusetts, United States,
4
National Cancer Institute, Bethesda, Maryland, United States#205
Annotation-free deep learning identifies cellular neighborhoods
associated with responses to immunotherapy in patients withmelanoma
D. Jimenez-Sanchez, B. Green, J. Roskes, L. Engle, M. Eminizer,
A. Szalay, J. TaubeJohns Hopkins University, Baltimore, Maryland, United States#1548
Identification of a neutrophil-specific PIK3R1 mutation facilitatestargeted treatment in a patient with sweet syndrome
S. Bhattacharya1, S. Basu1, E. Sheng1, J. Wei1, A. Kersh1, C. Nelson1,
J. Bryer1, H. Ashchyan1, K. Steele1, A. Forrestel1, J. T. Seykora1,
R. Micheletti1, W. James1, 2, M. Rosenbach1, T. Leung1, 2
1
Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania,
United States, 2Dermatology, VA Medical Center Corporal Michael J
Crescenz, Philadelphia, Pennsylvania, United States#1597
Topical calcipotriol plus 5-fluorouracil immunotherapy eliminates
premalignant skin lesions through a T helper 2 cell/interleukin-24
axis
V. Oliver-García1, T. Oka1, H. G. Son1, M. Azin1, T. Cunningham1,
M. Tabacchi2, L. Cornelius2, S. Demehri11Dermatology and Cancer Center, Massachusetts General Hospital,
Boston, Massachusetts, United States, 2Dermatology Division,
Washington University in St Louis School of Medicine, St Louis, Missouri,
United States#218
Predicting mortality in systemic sclerosis patients using machinelearning approaches
A. Jang1, S. Patel2, S. Patel1, S. Shah3, P. Lio1
1
Northwestern University Feinberg School of Medicine, Chicago, Illinois,
United States, 2University of Miami School of Medicine, Miami, Florida,
United States, 3University of Missouri Kansas City School of Medicine,Kansas City, Missouri, United States#1568
Identification of fibroinflammatory and fibrotic transcriptomic
subsets of human sclerotic cutaneous chronic graft-versus-hostdiseaseR. Rosenstein2, J. Rose3, S. Brooks1, W. Tsai1, M. Gadina1, S. Pavletic4,
K. Nagao1, E. Cowen1
1
National Institute of Arthritis and Musculoskeletal and Skin Diseases,
Bethesda, Maryland, United States, 2Hackensack Meridian Hackensack

94

#1620
The cutaneous somatic landscape of prurigo nodularis
A. Rajeh1, 2, H. Cornman1, A. Kambala1, M. D. Szeto1, O. O. Oladipo1,
V. Parthasarathy1, J. Deng1, S. V. Reddy1, Y. Semenov2, A. Gusev3,
S. Kang1, S. Kwatra1
1
Department of Dermatology, Johns Hopkins University Schoolof Medicine, Baltimore, Maryland, United States, 2Department of
Dermatology, Massachusetts General Hospital, Boston, Massachusetts,
United States, 3Department of Medical Oncology, Dana-Farber Cancer
Institute, Boston, Massachusetts, United States#208
Deep learning–based automatic assessment and cluster analysis of
atopic dermatitis: A model for predicting therapeutic efficacy
K. Nakamoto1, Y. Hayashida1, K. Tetsushi2, Y. Aoyama1
1
Dermatology, Kawasaki Ika Daigaku, Kurashiki, Japan, 2ResearchInstitute for Nanodevices, Hiroshima Daigaku, Higashihiroshima,
Hiroshima, Japan#1542
Allergen sensitization status stratifies IL-31 production by memory T
cells in atopic dermatitis
L. Sans-De San Nicolàs1, I. Figueras-Nart2, I. García-Jiménez1,
M. Bonfill-Ortí2, A. Guilabert3, L. Curto-Barredo4, M. Bertolín-Colilla4,
M. Ferran4, E. Serra-Baldrich5, R. Pujol4, L. Santamaria-Babí1
1
Immunologia Translacional, Universitat de Barcelona Facultat deBiologia, Barcelona, Spain, 2Dermatologia, Hospital Universitari de
Bellvitge, L'Hospitalet de Llobregat, Spain, 3Dermatologia, Hospital
General de Granollers, Granollers, Spain, 4Dermatologia, Hospital delMar, Barcelona, Spain, 5Dermatologia, Hospital de la Santa Creu i Sant
Pau, Barcelona, Spain#1544
Disruption of a pathologic, skin-resident T17 cell identity in clinicallyeffective IL23 blockade of psoriasis
D. Wu1, A. Hailer1, Y. Liu1, S. Wang1, E. Purdom2, J. P. North3, R. Cho1,
J. Cheng4, 1
1
Department of Dermatology, University of California San Francisco,
San Francisco, California, United States, 2Department of Statistics,
University of California Berkeley, Berkeley, California, United States,
3
Dermatopathology Service, University of California San Francisco, San
Francisco, California, United States, 4Dermatology, San Francisco VA
Health Care System, San Francisco, California, United States

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Continued on next page.

Select ePoster Discussions, Session 2
Artificial Intelligence (AI) and Image Analysis/
Translational Studies/Pigmentation & Melanoma - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #1––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#1244
Epigenetic & metabolic vulnerabilities of adaptive drug resistance totargeted therapies in melanoma
J. Torrano1, D. Ravindran-Menon2, H. Hammerlindl3, S. Hammerlindl3,
A. A. Emran4, N. Bordag5, E. Zuegner5, N. K. Haass1, M. Sadowski6,
J. Stow7, C. Magnes5, M. Fujita2, H. Schaider1
1
Frazer Institute, The University of Queensland Faculty of Medicine,
Brisbane, Queensland, Australia, 2Department of Dermatology, Universityof Colorado Anschutz Medical Campus School of Medicine, Aurora,
Colorado, United States, 3Department of Pharmaceutical Chemistry,
University of California San Francisco, San Francisco, California,
United States, 4Cutaneous Biology Research Center, Massachusetts
General Hospital, Boston, Massachusetts, United States, 5JOANNEUM
RESEARCH Forschungsgesellschaft mbH, Graz, Steiermark, Austria,
6
Australian Prostate Cancer Research Centre Queensland, Brisbane,
Queensland, Australia, 7The University of Queensland Institute for
Molecular Bioscience, Brisbane, Queensland, Australia#1217
Itaconate inhibits dendritic cell and CD8+T cell-mediated autoimmune
response and halts vitiligo depigmentation
Y. Wang, J. Ma, P. Kang, J. Chen, Y. Yang, P. Du, S. Li, C. Li
Xijing Hospital, Xian, Shaanxi, China#1280
Melanin synthesis drives global reprogramming of cellular and tissue
metabolism
Z. Eraslan, M. Yusupova, J. You, C. Konrad, Q. Chen, S. Gross, G.
Manfredi, J. Zippin
Weill Cornell Medicine, New York, New York, United States#1209
The fate of melanocytes and the disorganization of basement
membrane in a guinea pig model of rhododendrol-induced chemical
vitiligo
Y. Kuroda1, 2, L. Yang1, F. Yang1, 2, S. Lai1, T. Sayo1, 2, Y. Takahashi1, 2,
D. Tsuruta3, I. Katayama1
1
Department of Pigmentation Research and Therapeutics, Osaka Koritsu
Daigaku Igakubu Daigakuin Igaku Kenkyuka, Osaka, Japan, 2Biological
Science Research Laboratories, Kao Kabushiki Kaisha Odawara
Kenkyujo, Odawara, Kanagawa, Japan, 3Department of Dermatology,
Osaka Koritsu Daigaku Igakubu Daigakuin Igaku Kenkyuka, Osaka, Japan#1234
Immunotherapy induces clonal expansion of cytotoxic tumor-specific
TILs in a model of melanoma
G. Micevic1, 2, A. Daniels1, 2, K. Flem-Karlsen1, R. Talty1, K. Park1,
M. Bosenberg1, R. Flavell2
1
Dermatology, Yale School of Medicine, New Haven, Connecticut, UnitedStates, 2Immunobiology, Yale University, New Haven, Connecticut,
United States#1250
Induction of tertiary lymphoid structures in a mouse melanoma model
under a combination of CXCL13 and anti-PD-1 antibody
M. Yoshimitsu, M. Nakamura, S. Kano, T. Magara, H. Kato, A. Morita
Geriatric and Environmental Dermatology, Nagoya Shiritsu Daigaku
Daigakuin Igaku Kenkyuka Igakubu, Nagoya, Aichi, Japan#1252
Interferon mediated resistance of melanoma cells to oncolytic viruses
is regulated by the melanocyte lineage transcription factor MITF
S. Gellert1, A. Buzzai1, B. Kruse1, J. Marine2, F. Rambow3, T. Tüting1
1
Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultat,
Magdeburg, Germany, 2Vlaams Instituut voor Biotechnologie KU Leuven
Center for Cancer Biology, Leuven, Belgium, 3Department of Applied
Computational Cancer Research, University Hospital Essen, Essen,
Germany#1199
PYK2 regulates PD-L1 expression via JAK/STAT signaling inmelanoma
Y. Mizuno1, 2, M. Umemura2, F. Suzuki2, R. Nakakaji2, Y. Yamaguchi1, Y.
Ishikawa2
1
Department of Environmental Immuno-Dermatology, Yokohama Shiritsu
Daigaku Igakubu Daigakuin Igaku Kenkyuka, Yokohama, Kanagawa,Japan, 2Cardiovascular Research Institute (CVRI), Yokohama Shiritsu
Daigaku Igakubu Daigakuin Igaku Kenkyuka, Yokohama, Kanagawa,
Japan

#1201
Single-cell, spatial profiling of heterogeneous melanocytic
neoplasms
N. Love, M. Kiuru
Dermatology, University of California Davis, Sacramento, California,
United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

95

Select ePoster Discussions, Session 2

Innate Immunity, Microbiology, and Microbiome I & II
Studies of cells, receptors and effector molecules of the innate immune response; studies on skin microbes, microbiome and infectious processesof the skin.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #2––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Yu Sawada, Dr. Jeremy Di Domizio, Dr. Tamia A. Harris-Tryon#1015
Immunomodulatory roles of danger-associated molecular patterns inskin inflammation
P. R. Murphy, S. Kumari
Frazer Institute, The University of Queensland, Brisbane, Queensland,
Australia#954
Differential regulation of comedogenesis and folliculitis by free fatty
acids metabolized by cutibacterium acnes: Comprehensive analysis
of human acne subjects and animal model
T. Sugihira1, 2, N. Inohara3, Y. Sato2, T. Ishii2, Y. Matsuoka-Nakamura1, 4,
M. Fujimoto1
1
Department of Dermatology, Graduate School of Medicine, Osaka
University, Suita, Japan, 2Basic Research Development Division,
Rohto Pharmaceutical Co Ltd, Kizu, Japan, 3Department of Pathology,
University of Michigan, Ann Arbor, Michigan, United States, 4Cutaneous
Allergy and Host Defense, Immunology Frontier Research Center, Osaka
University, Suita, Japan#1001
Gut bacterial sphingolipid production regulates the skin microbiome,
skin lipid production and skin barrier homeostasis
M. Lee1, T. A. Harris-Tryon2, E. L. Johnson1
1
Division of Nutritional Sciences, Cornell University, Ithaca, New York,
United States, 2Dermatology, The University of Texas Southwestern
Medical Center, Dallas, Texas, United States#1037
Triggering receptor expressed on myeloid cells (TREM)-1 modulates
cutaneous immune responses and prevents skin cancer
N. Yusuf1, C. Mier-Aguilar1, M. A. Sherwani1, Y. Tsuruta1, H. Rashid1,
D. Crossman2, H. Xu1
1
Dermatology, The University of Alabama at Birmingham, Birmingham,
Alabama, United States, 2Genetics, The University of Alabama at
Birmingham, Birmingham, Alabama, United States#942
Inefficient senescent fibroblast clearance in aging skin: The
contribution of impaired natural killer cells
A. Koroma, K. Shekhawat, M. Wlaschek, P. Maity, K. ScharffetterKochanek
Dermatology, Universitat Ulm, Ulm, Baden-Württemberg, Germany#949
Lipopeptides derived from skin bacteria modulate the allergic
response in human and mouse skin
H. Williams1, R. Muko2, E. Wright1, H. Matsuda2, P. Arkwright1,
A. Tanaka2, J. Pennock1
1
Lydia Becker Institute of Immunology & Inflammation, The Universityof Manchester, Manchester, United Kingdom, 2Laboratory of Veterinary
Molecular Pathology & Therapeutics, Tokyo Noko Daigaku, Fuchu, Tokyo,
Japan

#1020
Comprehensive search for therapeutic targets and understanding offibrosis in hidradenitis suppurativa
T. Omine, D. Utsumi, S. Yamaguchi, K. Takahashi
Dermatology, University of the Ryukyus, Graduate school of Medicine,
Nakagami-gun, Okinawa, Japan#965
The importance of CD206+ macrophages in squaric acid dibutylesterinduced hair cycle activation
K. Tomii1, 2, T. Katakai2, R. Abe1
1
Division of Dermatology, Niigata University Graduate School of Medical
and Dental Sciences, Niigata, Japan, 2Department of Immunology,
Niigata University Graduate School of Medical and Dental Sciences,
Niigata, Japan#978
Modulation of IL-36-triggered signaling in skin keratinocytes by
AMPK
N. Wu1, 2, 3, Y. Huang4, L. Chiu1, 2, 4, J. Wang1, 3
1
Department of Medicine, Mackay Medical College, Sanzhi, Taipei,
Taiwan, 2Institute of Biomedical Sciences, Mackay Medical College,
Sanzhi, Taipei, Taiwan, 3Department of Dermatology, Mackay Memorial
Hospital, Taipei, Taiwan, 4Department of Medical Research, Mackay
Memorial Hospital, Taipei, Taiwan#955
Skin care improves newborn skin dysbiosis associated with atopic
dermatitis
T. Ito1, R. Aoyama1, S. Nakagawa2, Y. Yamazaki1, N. Inohara2,
Y. Ichikawa3, N. Shimojo4, Y. Matsuoka-Nakamura1, 5, 6, M. Fujimoto1, 5
1Department of Dermatology, Graduate School of Medicine, Osaka
University, Suita, Japan, 2Department of Pathology and Rogel Cancer
Center, University of Michigan Medical School, Ann Arbor, Michigan,
United States, 3Ichikawa Clinic, Fukushima, Japan, 4Center for Preventive
Medical Sciences, Chiba University, Chiba, Japan, 5Cutaneous
Immunology, Immunology Frontier Research Center, Osaka University,
Suita, Japan, 6Cutaneous Allergy and Host Defense, Immunology
Frontier Research Center, Osaka University, Suita, Japan
Continued on next page.

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Select ePoster Discussions, Session 2
Innate Immunity, Microbiology, and Microbiome I & II - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #2––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#999
Gastrointestinal colonization as a source of staphylococcus aureus
in atopic dermatitis
T. Karagounis1, M. Podkowik2, J. Shenderovich3, N. Arguelles3,
A. Srivastava3, C. Needle2, G. Putzel3, V. Oza1, A. Pironti3, V. Torres3,
B. Shopsin2, 3
1Ronald O. Perelman Department of Dermatology, NYU Langone Health,
New York, New York, United States, 2Department of Medicine, NYU
Langone Health, New York, New York, United States, 3Department ofMicrobiology, NYU Langone Health, New York, New York, United States#969
Epidermis-specific deletion of miR-149 exacerbates psoriasis-likeskin inflammation
L. Luo1, 2, A. Srivastava1, 3, J. Freisenhausen1, 2, P. Saha1, N. Khera1,
R. Prieux1, A. Monteiro1, A. Pivarcsi4, 2, 1, E. Sonkoly2, 4, 1
1
Dept of Medicine Solna, Karolinska Institutet, Stockholm, Stockholm,
Sweden, 2Department of Medical Sciences, Dermatology &venereology,
Uppsala Universitet, Uppsala, Sweden, 3Stanford University, Stanford,
California, United States, 4Department of Medical Biochemistry andMicrobiology, Uppsala Universitet, Uppsala, Sweden#1054
Circulating inflammatory monocytes associated with atopic
dermatitis microbial-defined endotypes
C. Chua1, R. Sethi1, J. Ong1, J. Low1, A. Tay1, Y. Yew2, S. Howland1,
F. Ginhoux1, J. Chen1, J. E. Common1, A. Andiappan1
1
Agency for Science Technology and Research, Singapore, Singapore,
2
National Skin Centre, Singapore, Singapore#1004
Dermal extracellular matrix inhibits mast cell activation to skincommensal bacteria
A. Di Nardo1, S. Alimohammadi1, K. Kuroki1, Y. Chang1, P. A. Insel2, 3
1
Dermatology, University of California San Diego School of Medicine, La
Jolla, California, United States, 2Pharmacology, University of California
San Diego School of Medicine, La Jolla, California, United States,
3
Medicine, University of California San Diego School of Medicine, La
Jolla, California, United States#908
T-cell receptor signaling and cellular metabolism regulate
IL-13-producing capacity of murine epidermal γδ T cells
A. Ibusuki1, K. Kawai1, 2, R. J. Argüello3, T. Kanekura1
1
Department of Dermatology, Kagoshima University Graduate Schoolof Medical and Dental Sciences, Kagoshima, Japan, 2Department of
Dermatology, Kido Hospital, Niigata, Japan, 3Aix Marseille Université,
CNRS, INSERM, CIML, Centre d’Immunologie de Marseille-Luminy,
Marseille, France#911
Mature interleukin-36γ induces epidermal stratum corneum
exfoliation in generalized pustular psoriasis via downregulation of
corneodesmosine
E. Sato, H. Imayohi, Y. Tsutsui, H. Shimizu, S. Imafuku
Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan#1040
Calprotectin plays a role in regulating inflammatory cytokine
production in human macrophages post-Cutibacterium acnes
infection
T. Hsu3, M. Qin1, S. Gilliland3, G. Agak2, J. Kim1
1
Medicine, University of California Los Angeles David Geffen School of
Medicine, Los Angeles, California, United States, 2Medicine, University ofCalifornia Los Angeles David Geffen School of Medicine, Los Angeles,
California, United States, 3University of California Los Angeles, Los
Angeles, California, United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Select ePoster Discussions, Session 2

Cell-Cell Interactions in the Skin/Epidermal Structure and Barrier Function
Studies on cell-cell interactions between specific skin cell types (including but not limited to keratinocytes, nerves (neuro-cutaneous biology),melanocytes, fibroblasts, adipocytes, immune cells and progenitors) in the skin and their local cellular and extracellular environments that affectskin inflammation, sensation (e.g., itch and pain), signaling, adhesion, migration, development and homeostasis/ Research on the components or
regulation of keratinocyte proliferation, differentiation, including epidermal barrier maintenance and function.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #3––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Satoru Shinkuma, Dr. Takashi Matsushita, Dr. Adam Glick#342
Single-cell RNA-seq reveals keratinocytes and fibroblasts arepotential key cellular targets of IL-31 in prurigo nodularis
K. Katsuo, S. Nakamizo, G. Egawa, K. Kabashima
Kyoto Daigaku Daigakuin Igaku Kenkyuka Igakubu, Kyoto, Japan#330
The aryl hydrocarbon receptor contributes to histamine-evoked itchwith the involvement of TRPV1 in dorsal root ganglia
H. Yue1, 2, G. Peng1, 2, Y. Umehara2, L. Nguyen1, 2, A. Ikeda2, 3,
K. Okumura2, H. Ogawa2, S. Ikeda1, 2, F. Niyonsaba2, 4
1
Department of Dermatology and Allergology, Juntendo Daigaku Igakubu
Daigakuin Igaku Kenkyuka, Bunkyo-ku, Tokyo, Japan, 2Atopy (Allergy)
Research Center, Juntendo Daigaku Igakubu Daigakuin Igaku Kenkyuka,
Bunkyo-ku, Tokyo, Japan, 3Department of Nephrology, Juntendo Daigaku
Igakubu Daigakuin Igaku Kenkyuka, Bunkyo-ku, Tokyo, Japan, 4Faculty ofInternational Liberal Arts, Juntendo Daigaku, Bunkyo-ku, Tokyo, Japan#332
Extensive interactions between keratinocytes and immune cells in
psoriatic epidermis revealed by single-cell transcriptomics
L. Luo1, 2, 4, H. Cheng3, M. Enge3, A. Pivarcsi1, 4, E. Sonkoly1, 2, 4
1
Department of Medical Biochemistry and Microbiology (IMBIM), Uppsala
Universitet, Uppsala, Sweden, 2Department of Medical Sciences, Uppsala
Universitet, Uppsala, Sweden, 3Department of Oncology and Pathology,
Karolinska Institutet, Stockholm, Stockholm, Sweden, 4Department ofMedicine Solna, Karolinska Institutet, Stockholm, Stockholm, Sweden#366
CD4+ T cells eradicate IFN-unresponsive melanomas that resist CD8+
T cell therapy
B. Kruse1, A. Buzzai1, N. Shridhar1, A. Braun1, S. Gellert1, K. Knauth1,
J. Peters1, M. Mengoni1, T. van der Sluis1, A. Krone1, D. Yu3, S.
Höhn1, Y. Fu1, M. Essand3, R. Geffers4, D. Mougiakakos1, S. Kahlfuß1,
H. Kashkar5, E. Gaffal1, W. Kastenmüller2, A. Müller1, T. Tüting1
1
Otto-von-Guericke-Universitat Magdeburg Medizinische Fakultat,
Magdeburg, Sachsen-Anhalt, Germany, 2Julius-Maximilians-Universitat
Wurzburg, Wurzburg, Bayern, Germany, 3Uppsala Universitet, Uppsala,Sweden, 4Helmholtz-Zentrum fur Infektionsforschung GmbH,
Braunschweig, Niedersachsen, Germany, 5Universitat zu Koln, Koln,
Nordrhein-Westfalen, Germany

Multiplexed spatial mapping of panniculitis: Deciphering thesignatures of subcutaneous adipose tissue inflammation
R. Ziadlou, M. M. Ameri, M. Brüggen
UniversitatsSpital Zurich Dermatologische Klinik, Zurich, ZH, Switzerland#343
Exosomes containing miRNAs from keratinocytes under oxidative
stress contribute to the destruction of melanocytes and CD8+ T cell
activation in vitiligo
J. Ma, Y. Yang, S. Guo, T. Gao, C. Li, Z. Jian
Department of Dermatology, Xijing Hospital, Xi'an, Shaanxi, China#346
Leveraging skin immunity to counteract senescence
M. Mangier, A. Mauroux, C. Mainzer, S. Bordes, E. Aymard, B. ClossR&D Department, SILAB, Brive, France#367
Inducible loss of claudin-1 in keratinocytes leads to the induction ofitch transmitted by multiple types of sensory nerves
S. Toshima1, 2, S. Takahashi1, A. Kubo2, 3, M. Amagai2, 4, T. Okada1
1
Laboratory for Tissue Dynamics, Center for Integrative Medical Science,
RIKEN, Yokohama, Japan, 2Department of Dermatology, Keio University
School of Medicine, Tokyo, Japan, 3Division of Dermatology, Department
of Internal Related, Kobe University Graduate School of Medicine, Kobe,
Japan, 4Laboratory for Skin Homeostasis, Center for Integrative Medical
Science, RIKEN, Yokohama, Japan#331
UBE2L3 reduces interleukin-1β secretion in epidermal keratinocytes
and deficiency of UBE2L3 results in spontaneous psoriasis-likedermatitis
X. Chen, X. Man
Zhejiang University School of Medicine Second Affiliated Hospital,
Hangzhou, Zhejiang, China#748
Cutibacterium acnes supports the epidermal barrier by promoting
epidermal lipid synthesis
S. Almoughrabie1, 2, L. Cau2, K. Cavagnero1, A. O'Neill1, F. Li1,
A. Roso Mares1, C. Mainzer2, B. Closs2, M. Kolar1, K. Williams3,
S. Besinger4, R. L. Gallo1
1
Dermatology, UCSD, La Jolla, California, United States, 2R&D Department,
SILAB, Brive, France, 3University of California Los Angeles, Los Angeles,
California, United States, 4University of California Los Angeles, Los
Angeles, California, United States
Continued on next page.

#362

#699

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Select ePoster Discussions, Session 2
Cell-Cell Interactions in the Skin/Epidermal Structure and Function - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #3––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––TEX264 drives autophagic degradation of the endoplasmic reticulumin keratinocytes during epidermal differentiation and upon ER stress
C. L. Simpson, C. J. Johnson, A. Tiwaa
Dermatology, University of Washington, Seattle, Washington, UnitedStates#788
Ferroptosis enhances epidermal cornification through transcriptionaland metabolic reprogramming
N. Kuprasertkul1, 2, C. Magahis1, S. Egolf1, 2, C. L. Simpson3,
C. Mesaros4, K. E. Wellen5, 2, B. C. Capell1, 2
1
Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania,
United States, 2Penn Epigenetics Institute, University of Pennsylvania,
Philadelphia, Pennsylvania, United States, 3Dermatology, Universityof Washington, Seattle, Washington, United States, 4Pharmacology,
University of Pennsylvania, Philadelphia, Pennsylvania, United States,
5
Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania,
United States#767
Znf750 regulates skin barrier functions independently of epidermal
differentiation
B. Schwartz1, H. Levy1, G. Menon2, L. Oss-Ronen1, I. Cohen11
Microbiology, Immunology and Genetics, Ben-Gurion University of the
Negev, Beer-Sheva, Southern, Israel, 2California Academy of Sciences,
San Francisco, California, United States#782
Fucosyltransferase 1 plays a protective role in the development of
atopic dermatitis-like disease in mice
Y. Lee1, 2, 3, N. Li1, 2, 3, J. Oh1, 2, 3, J. Suh1, 2, 3, D. Lee1, 2, 3, J. Chung1, 2, 3
1
Department of Dermatology, Seoul National University Collegeof Medicine, Seoul, Korea (the Republic of), 2Institute of HumanEnvironment Interface Biology, Medical Research Center, Seoul National
University, Seoul, Korea (the Republic of), 3Laboratory of Cutaneous
Aging Research, Biomedical Research Institute, Seoul National University
Hospital, Seoul, Korea (the Republic of)#727
Contact hypersensitivity in the absence of loricrin: A checkpoint of
percutaneous adaptive immunity
Y. Ishitsuka1, T. Ogawa3, D. R. Roop2, M. Fujimoto1
1
Dermatology, Osaka Daigaku Daigakuin Igakukei Kenkyuka Igakubu,
Suita, Osaka, Japan, 2Department of Dermatology and Charles C. Gates
Center for Regenerative Medicine, University of Colorado Anschutz
Medical Campus, Aurora, Colorado, United States, 3Dermatology,
Tsukuba Daigaku Igaku Iryokei, Tsukuba, Ibaraki, Japan

Loss of pinin induces differentiation of human epidermal
keratinocytes
T. Makino1, S. Yamamoto2, Y. Tabuchi3, M. Mizawa1, K. Takemoto1,
T. Shimizu1
1
Dermatology, Toyama Daigaku, Toyama, Toyama, Japan, 2Pathology,
Toyama Daigaku, Toyama, Toyama, Japan, 3Division of Molecular
Genetics Research, Life Science Center, Toyama Daigaku, Toyama,
Toyama, Japan#794
Region-specific differences in human epidermal differentiation at asingle-cell level
J. Wiedemann1, A. Billi2, F. Bocci1, E. Xing2, Q. Nie1, J. Gudjonsson2,
B. Andersen1
1
University of California Irvine, Irvine, California, United States, 2Universityof Michigan, Ann Arbor, Michigan, United States#714
Stratum corneum homeostasis requires three-stepwise pH zones
mediated by the functional cell death of keratinocytes, corneoptosis
K. Fukuda1, 2, Y. Ito2, Y. Furuichi2, T. Miyano3, R. Tanaka3, T. Matsui4,
M. Amagai1, 2
1Skin Homeostasis, RIKEN-IMS, Yokohama, Japan, 2Dermatology, Keio
University, Tokyo, Japan, 3Bioengineering, ICL, London, United Kingdom,
4
Evolutionary Cell Biology of the Skin, TUT, Hachioji, Japan

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

#724

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Select ePoster Discussions, Session 2
Pharmacology and Drug Development/Clinical Research-Interventional Research/
Clinical Research-Socio-behavioral and Health Services Research
Basic and preclinical studies aimed at developing therapeutics, elucidating their mechanisms of action, and identifying biomarkers of drug activity/
Interventional human trials that evaluate or compare therapies, devices, or other interventions for the treatment of skin diseases. This may include
systematic reviews and/or meta-analyses of interventional studies/Socio-behavioral studies may include, but are not limited to, studies of patient
and/or provider behaviors and attitudes towards diseases, treatments, diagnostic and screening tests, and health care delivery. Health services
research studies may include, but are not limited to, studies of access, use, delivery, quality, and cost-effectiveness of dermatologic care.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #4––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Toshifumi Nomura, Dr. Dong Hun Lee, Dr. Mackenzie Wehner,
Dr. Marta Bertolini#1096
The PARP14 inhibitor RBN-3143 suppresses skin inflammation in
preclinical models
M. Niepel1, M. Vasbinder1, K. Kunii1, G. Bin1, E. Mateer1, C. Coutts1,
K. Kuplast-Barr1, H. Kaur2, J. Novak1, D. Blackwell1, N. Perl1,
J. R. Molina1, L. B. Schenkel1, K. Swinger1, K. McEachern1, V. Bozon1,
C. T. Richardson2, L. Beck2, S. Parasuraman1, K. Kuntz1, H. Keilhack1
1
Ribon Therapeutics Inc, Cambridge, Massachusetts, United States,
2
University of Rochester Medical Center, Rochester, New York, UnitedStates#1093
A zinc deficiency enhances mu-opioid receptor-mediated pruritus
H. Sano, T. Oguro, K. Nakajima, R. Kamijima, M. Takaishi, S. Sano
Kochi Daigaku Igakubu Daigakuin Ikagaku Senko, Nankoku, Kochi, Japan#1063
Small molecule antagonists of interleukin 17 offer an orthogonal
approach to inhibit key inflammatory processes
E. R. Goedken1, M. A. Argiriadi1, J. D. Dietrich2, A. M. Petros2,
S. C. Panchal2, W. Qiu2, H. Wu2, H. Zhu2, M. Srikumaran2,
S. M. Gopalakrishnan2, P. B. Cox2, V. C. Stoll2, C. Sun2
1
AbbVie Bioresearch Center, Worcester, Massachusetts, United States,
2
AbbVie Inc, North Chicago, Illinois, United States#1073
Fasudil ameliorates fibrosis and immune abnormalities in animalmodels of systemic sclerosis
T. Toyama1, Y. Asano2, S. Sato3, M. Sugaya1
1
Dermatology, Kokusai Iryo Fukushi Daigaku Narita Byoin, Narita, Chiba,
Japan, 2Dermatology, Tohoku Daigaku Daigakuin Igakukei Kenkyuka
Igakubu, Sendai, Miyagi, Japan, 3Dermatology, Tokyo Daigaku Daigakuin
Igakukei Kenkyuka Igakubu, Bunkyo-ku, Tokyo, Japan

K. Gross1, Q. Tang1, 2, M. Zain Ul Abideen1, H. Fakih1, R. Furgal1,
C. Blanchard3, C. Bouix-peter3, T. Portal3, A. Khvorova1, J. E. Harris2,
J. Alterman1
1
RNA Therapeutics Institute, University of Massachusetts Chan Medical
School, Worcester, Massachusetts, United States, 2Department of
Dermatology, University of Massachusetts Chan Medical School,
Worcester, Massachusetts, United States, 3Aldena Therapeutics, Boston,
Massachusetts, United States#1077
Efficacy and safety of ENERGI-F701 solution versus 2% minoxidil
solution for female pattern hair loss: a phase II, multi-center,randomized, double-blind, head-to-head, parallel trial
S. Ma1, Y. Wei1, M. Wu2, H. Tsai3, D. Lee1, Y. Chang1, C. Chen1
1
Taipei Veterans General Hospital, Taipei, Taiwan, 2Taichung Armed
Forces General Hospital, Taichung, Taiwan, 3Taipei Medical University
Hospital, Taipei, Taiwan#1095
A2a regulates the polarization of M1 macrophages to initiate innate
immunity in psoriasis
Y. Lu, J. Chen, W. Zhu, H. Liu, Y. Kuang
Xiangya Hospital Central South University, Changsha, Hunan, China#676
Urgent care referrals demonstrate need for “real-time” dermatology
e-consultation
S. Rahman1, A. Bowden1, C. Green2, J. Ryan Wolf2
1
University of Rochester School of Medicine and Dentistry, Rochester,
New York, United States, 2Dermatology, University of Rochester Medical
Center, Rochester, New York, United States#688
Using implementation science approaches to select and prioritize
potential antibiotic stewardship interventions in acne
L. Chu1, S. Gold1, C. Escoffery2, H. Yeung1
1
Dermatology, Emory University School of Medicine, Atlanta, Georgia,
United States, 2Emory University School of Public Health, Atlanta,
Georgia, United States#1106
Inhibition of cellular senescence by apocynin in human keratinocytes
irradiated with ultraviolet b
T. Ansary, K. Kamiya, M. Hossain, M. Ohtsuki, M. Komine
Dermatology, Jichi Ika Daigaku, Shimotsuke, Tochigi, Japan#1129
Chemical engineering of therapeutic siRNAs for the modulation ofgene expression following intradermal administration in the skin100

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Select ePoster Discussions, Session 2
Pharmacology and Drug Development/Clinical Research-Interventional Research/
Clinical Research-Socio-behavioral and Health Services Research - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #4––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#675
FDA advisory panel members recommend process improvements
U. Nadir1, M. D. Yi1, L. Dave1, F. Ikmal-Hisham1, A. Maisel-Campbell1, 2,
B. D. Cressey3, A. Weil1, A. Y. Lee4, E. Poon1, M. Alam1, 5, 6
1
Dermatology, Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States, 2Dermatology, Columbia University, New
York, New York, United States, 3Northeast Dermatology Associates PA,
Portsmouth, Massachusetts, United States, 4Marketing, Northwestern
University Kellogg School of Management, Evanston, Illinois, UnitedStates, 5Otolaryngology, Northwestern University Feinberg Schoolof Medicine, Chicago, Illinois, United States, 6Surgery, Northwestern
University Feinberg School of Medicine, Chicago, Illinois, United States#589
Patients with advanced melanoma who benefit from the addition ofanti-CTLA-4 to anti-PD-1 have a distinct tumor microenvironment(TME)
N. M. D'Amiano, E. Will, J. S. Deutsch, L. Engle, S. Berry, B. Green, A.
Szalay, E. Lipson, J. TaubeJohns Hopkins University, Baltimore, Maryland, United States#588
Influence of pathogenic filaggrin variants on dupilumab treatment in
atopic dermatitis
J. Clabbers1, C. Boesjes2, L. Spekhorst2, M. van Geel3, P. Steijlen1,
M. de Bruin-Weller2, A. Gostynski1
1
Dermatology, Maastricht Universitair Medisch Centrum+, Maastricht,
Limburg, Netherlands, 2Dermatology, Universitair Medisch Centrum
Utrecht, Utrecht, Utrecht, Netherlands, 3Clinical Genetics, Maastricht
Universitair Medisch Centrum+, Maastricht, Limburg, Netherlands#666
Patient-reported impact of dermatological diseases (PRIDD)
measure: Pemphigus and pemphigoid delphi data
N. Trialonis-Suthakharan1, R. Pattinson3, J. Austin4, A. FitzGerald4,
M. Yale2, C. Bundy3, M. Augustin1
1
Institute od Health Services Research in Dermatology and Nursing(IVDP), Universitatsklinikum Hamburg-Eppendorf, Hamburg, Hamburg,
Germany, 2International Pemphigus and Pemphigoid Foundation(IPPF), Roseville, California, United States, 3Cardiff University Schoolof Healthcare Sciences, Cardiff, Cardiff, United Kingdom, 4International
Alliance of Dermatology Patient Organization, Ottawa, Ontario, Canada#671
Time-to-treatment and recurrence for head and neck Merkel cell
carcinoma treated with Mohs micrographic surgery and sentinel
lymph node biopsy
S. K. Lin, A. M. Deitermann, K. Ricciardelli, C. J. Miller, Y. Wu, J.
Etzkorn, J. Sobanko
University of Pennsylvania, Philadelphia, Pennsylvania, United States#680
Identification of environmental, demographic and lifestyle risk
factors for cutaneous T cell lymphoma: A single institution casecontrol study
Z. Ren, M. Nguyen, M. J. Hooper, T. Lewitt, Y. Pang, F. Veon, L.
Ayanruoh, T. Griffin, J. Guitart, X. Zhou
Northwestern University Feinberg School of Medicine, Chicago, Illinois,
United States#634
Assessing the effects of systemic therapy for vascular malformations
using RNAseq
J. M. Teng1, M. Winge1, M. F. Qian2
1dermatology, Stanford University School of Medicine, Stanford,
California, United States, 2Stanford University School of Medicine,
Stanford, California, United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

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Select ePoster Discussions, Session 2

Late-Breaking Abstract Submissions––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #5––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Akihiko Uchiyama, Dr. Eugene Semenov#LB 1714
Increased epidermal penetration in aged skin modulates systemic
inflammation
A. Celli1, M. Man2, J. Gonzalez1, T. Parenteau3, J. M. Meyer4,
P. Elias1, 2, K. Abuabara1, C. Grunfeld1, 2, T. C. Scharschmidt1, T. Mauro1, 2
1
Dermatology, University of California San Francisco, San Francisco,California, United States, 2Dermatology, San Francisco VA HealthCare System, San Francisco, California, United States, 3Geriatrics,
University of California San Francisco, San Francisco, California, UnitedStates, 4Dermatology, Vanderbilt University Medical Center, Nashville,
Tennessee, United States#LB 1787
Tuning biomaterial stiffness augments innate and adaptive immune
responses in the skin
K. M. Kelly-Scumpia3, L. Shang4, 1, J. S. Weinstein5, D. Di Carlo4,
P. O. Scumpia1, 2
1
Medicine/Dermatology, University of California Los Angeles, Los
Angeles, California, United States, 2Dermatology, VA Greater Los
Angeles Healthcare System, Los Angeles, California, United States,
3
Medicine/Cardiology, University of California Los Angeles, Los Angeles,
California, United States, 4Bioengineering, University of California Los
Angeles, Los Angeles, California, United States, 5Center of Immunology
and Inflammation, Rutgers The State University of New Jersey, Newark,
New Jersey, United States#LB 1726
Pathogenic contribution of ADAR1 mutations to severe plaquepsoriasis
F. Assan1, M. McGrath1, M. Fremond2, A. Izmiryan1, Y. Crow2, B. Hervé1
1
Genetic Skin Diseases, INSERM U1163, Institut Imagine, Paris, France,
2
Neurogenetics and Neuroinflammation, INSERM U1163, Institut
Imagine, Paris, France#LB 1730
Concordance in the secretome of recessive dystrophic epidermolysis
bullosa and cellular senescence reveals COL7A1 dependent
perturbations
S. A. Koutsoukos1, M. Pavlova1, P. S. McGrath2, S. McGarvey1,
J. Castillo Flores1, A. Bruckner3, D. R. Roop1, I. Kogut1, G. Bilousova11
Department of Dermatology, University of Colorado Anschutz Medical
Campus, Aurora, Colorado, United States, 2Department of Pediatrics,
University of Colorado Anschutz Medical Campus, Aurora, Colorado,United States, 3Children's Hospital Colorado, Aurora, Colorado, UnitedStates#LB 1758
Regulation of the Independent Skin Circadian Clock by Specific Opsin
Using Human Skin Organotypic Culture
M. Bigliardi Qi, S. Lo, E. Bigliardi, S. Park, C. Markale, P. Bigliardi
Dermatology, University of Minnesota Twin Cities, Minneapolis,
Minnesota, United States#LB 1799
Single-cell type proteomic analysis in FFPE tissue sections of severe
cutaneous adverse drug reactions
T. Nordmann1, H. Anderton2, S. Lisa1, S. Ankit1, P. C. Stadler3, J. Silke2,
L. E. French3, M. Mann1
1
Proteomics and Signal Transduction, Max Planck Institute for
Biochemistry, Martinsried, Germany, 2Cell Signalling and Cell Deathdivision, Walter and Eliza Hall Institute of Medical Research, Melbourne,
Victoria, Australia, 3Department of Dermatology and Allergology, LudwigMaximilians-Universitat Munchen, Munchen, Bayern, Germany#LB 1715
Beyond established protection: adaptive epidermal barrier functions
regulate systemic energy metabolism and body composition
X. Ding1, 2, S. Willenborg2, S. Satzinger2, S. Brodesser3, S. Eming2, 3, 4
1School of Medicine, Shanghai University, Shanghai, Shanghai, China,
2
Department of Dermatology, Universitat zu Koln, Koln, NordrheinWestfalen, Germany, 3Cluster of Excellence Cellular stress responses
in Aging-associated diseases, Universitat zu Koln, Koln, NordrheinWestfalen, Germany, 4Center for Molecular Medicine Cologne, Universitat
zu Koln, Koln, Nordrhein-Westfalen, Germany#LB 1632
PD-1 signaling plays a critical role for inhibiting development of
autoimmune disease-associated dermatitis in childhood
K. Oya1, Y. Nakamura1, Z. Zhenji1, N. Okiyama2, T. Nomura1, Y. Fujisawa3
1
Dermatology, Tsukuba Daigaku, Tsukuba, Ibaraki, Japan, 2Dermatology,
Tokyo Ika Shika Daigaku, Bunkyo-ku, Tokyo, Japan, 3Dermatology, Ehime
Daigaku, Matsuyama, Ehime, Japan#LB 1694
Social and environmental context impacts racial disparities inpediatric atopic dermatitis severity in the Unites States
J. W. Gotschall, R. Fitzsimmons, D. B. Shin, J. Takeshita
Dermatology, University of Pennsylvania Perelman School of Medicine,Philadelphia, Pennsylvania, United States

Continued on next page.

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1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Select ePoster Discussions, Session 2
Late-Breaking Abstract Submissions - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––FRIDAY, MAY 12, 2023
18:10 – 19:40
NS BUILDING, ePOSTER STAGE #5––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––#LB 1698
Phase 2 study of the safety and efficacy of QTORIN rapamycin in thetreatment of microcystic lymphatic malformations
J. M. Teng1, J. Martini2, J. Treat4, J. Connor3, A. Small5, T. Funk5,
M. Waner6
1
Stanford University School of Medicine, Stanford, California, UnitedStates, 2Palvella Therapeutics, Wayne, Pennsylvania, United States,
3
Confluence Statistics, Coral Gabels, Florida, United States, 4The
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, UnitedStates, 5Oregon Health & Science University, Portland, Oregon, UnitedStates, 6Vascular Birthmark Institute, New York, New York, United States#LB 1709
Prevalence of skin cancer screening visits in Medicare data:a retrospective cohort study
M. K. Nowakowska1, Y. Li2, C. Mohr2, B. Smith3, L. Ferris4, M. Wehner2
1
Baylor College of Medicine, Houston, Texas, United States, 2The
University of Texas MD Anderson Cancer Center, Houston, Texas,
United States, 3Drexel University College of Medicine, Philadelphia,
Pennsylvania, United States, 4UPMC, Pittsburgh, Pennsylvania, UnitedStates#LB 1750
PC111, an anti-FasL neutralizing antibody, blocks pemphigus blister
formation in in-vitro, ex-vivo and in-vivo human models
R. Lotti2, 1, A. Marconi2, 1, A. Amato1, B. Bennett1, J. E. Hundt3,
C. M. Hammers3, R. J. Ludwig3, C. Pincelli2, 1
1
PinCell s.r.l., Milan, Italy, 2Universita degli Studi di Modena e Reggio
Emilia, Modena, Emilia-Romagna, Italy, 3University of Lubeck, Lubeck,Germany#LB 1794
Mechanisms regulating scar-free wound healing in long-lived naked
mole-rats
I. Fatima1, A. Mardaryev2, E. Rozhkova1, A. Seluanov3, V. Gorbunova3,
A. Veves4, A. Sharov1, V. A. Botchkarev1
1
Dermatology, Boston University School of Medicine, Boston,
Massachusetts, United States, 2Centre of Skin Sciences, University ofBradford, Bradford, West Yorkshire, United Kingdom, 3Biology, Universityof Rochester, Rochester, New York, United States, 4Surgery, Beth Israel
Deaconess Medical Center, Boston, Massachusetts, United States#LB 1800
TWEAK-induced apoptosis depletes desmoglein 1 and 3 via STAT1
in pemphigus
Y. Liu, X. Peng, Y. Xia
Dermatology, the Second Affiliated Hospital of Xi'an Jiaotong University,
Xi'an, China#LB 1790
RNAi-based topical formulation to treat chronic diabetic foot ulcers
P. Sampath1, 2, G. Subramanian1, K. Kalidasan1, J. Chan1, S. Quah1
1
A*STAR Skin Research Labs (A*SRL), Agency for Science Technology
and Research (A*STAR), Singapore, Singapore, 2Genome Institute ofSingapore, A*STAR, 60 Biopolis Street, Genome, Singapore, Singapore#LB 1774
Establishing competent morphogenetic fields for tissue patternregeneration in skin organoids
M. Lei1, J. Jiang1, W. Wu1, M. Wang1, J. Zhang1, Y. Lai2, H. Harn3,
L. Yang1, C. Chuong3
1
Bioengineering, Chongqing University, Chongqing, Chongqing, China,
2Integrative Stem Cell Center, China Medical University Hospital,
Taichung, Taiwan, 3Department of Pathology, University of Southern
California, Los Angeles, California, United States

Selected ePoster Discussions will take place during Poster Sessions that will occur on
Thursday and Friday of the ISID Meeting at iPad kiosks located inside of the Poster Hallat the NS Building. The discussions will be thematic tours of selected electronic posters
accompanied by a presenting author. Each poster presenter will be asked to briefly describe
their work (3 min), followed by a short group discussion (2 min), and that will be held with thehelp of a moderator. If your poster has been selected for ePoster Discussions, please join theappropriate group at the relevant ePoster kiosk.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING103

NOTES

www.isiderm.org
104

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGSATURDAY

MAY 13, 2023

SATURDAYNov division, TOKIWA Pharmaceutical Co., Ltd Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
07:00 – 08:00
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––New Technology Opens the Future of Dermatology
Chairs:Shinichi Sato, MD/PhD, Department of Dermatology,
The University of Tokyo Graduate School of Medicine
Manabu Fujimoto, MD/PhD, Department of Dermatology,
Osaka University Graduate School of Medicine

What can we learn from Fli1-deficient mice, new animal models of systemic sclerosis?
Yoshihide Asano, MD/PhD, Professor and Chairman, Department of Dermatology, Tohoku
University Graduate School of Medicine, Sendai, JAPAN.
Dr. Asano received his MD in 1998 at The University of Tokyo and completed his PhD training in
2004, also at The University of Tokyo. Dr. Asano spent two years of training as a Post-Doctoral
Fellow at the Division of Rheumatology and Immunology at the Medical College of South Carolina
from 2006-2008. He was appointed as Chairman of the Department of Dermatology at Tohoku
University in 2022. Dr. Asano’s research interest is in basic and clinical studies on scleroderma.

How to utilize genomics in dermatology 					Yukinori Okada, MD/PhD, Professor, Department of Genome Informatics, Graduate School of
Medicine, The University of Tokyo.
Dr. Okada received his MD and PhD from The University of Tokyo. His research focus is the
elucidation of mechanisms where genetic variants affect biological and clinical phenotype. He
has multiple professional backgrounds as a rheumatologist, a statistician, and a bioinformatician.
Through active collaborative partnerships among the researchers of human genetics, Prof. Okada
has conducted large-scale genetic studies of a variety of human complex traits.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

107

Amgen Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
07:00 – 08:00
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––CHAIRS:
Daisuke Tsuruta, MD/PhD, Professor, Department of Dermatology, Osaka Metropolitan
University Graduate School of Medicine, Japan
Hiroyuki Murota, MD/PhD, Professor, Department of Dermatology, Nagasaki University
Graduate School of Biomedical Sciences, Japan

SPEAKERS:
The possible role of psoriatic skin inflammation for the development of systemic organ
dysfunction and osteoporosis				Yu Sawada, MD/PhD, Department of Dermatology, University of Occupational andEnvironmental Health, Japan.
Dr. Sawada received his MD degree from the University of Occupational and Environmental
Health, Faculty of Medicine, and was a Junior Resident at the Kyushu Medical Center, andSenior Dermatology Resident in the Department of Dermatology, University of Occupational
and Environmental Health. He was a Visiting Scholar in the Department of Dermatology,
University of California, San Diego from 2018-2021. He was appointed Professor in the
Department of Dermatology, University of Occupational and Environmental Health in 2023.

Mitochondrial metabolism in psoriatic T cells 				Rei Watanabe, MD/PhD, Associate Professor, Department of Integrative Medicine for Allergic
and Immunological Diseases, Graduate School of Medicine/Faculty of Medicine, Osaka
University, Japan.
Dr Watanabe received her MD from the Faculty of Medicine, The University of Tokyo andcompleted her residency in the Department of Dermatology at The University of Tokyo
Hospital and Tokyo Kosei-Nenkin Hospital. She received her PhD from the Graduate Schoolof Medicine, The University of Tokyo. She was appointed as an Associate Professor in 2020.
Her research focuses on skin T cell biology.

108

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Sato Pharmaceutical/Eisai Co. Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
07:00 – 08:00
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Fosravuconazole, an Oral Antifungal Agent for the Treatment of
Onychomycosis: Basic Characteristics and Clinical Effects
CHAIRS:
Yoshiki Miyachi, MD/PhD, Professor Emeritus, Kyoto University, President, Shizuoka Graduate
University of Public Health, Shizuoka, JAPAN
Nikolas Haass, MD/PhD, Professor for Cutaneous Oncology and Director of Higher Degree
Research, Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane,
Queensland, AUS

SPEAKERS:
Mycological characteristics of the causative agents of onychomycosis
Takashi Sugita, PhD, Professor, Department of Microbiology, Meiji Pharmaceutical University(MPU), Dean of Graduate School of Pharmaceutical Science, MPU, Tokyo, JAPAN.
Professor Sugita received his PhD from Meiji Pharmaceutical University. He currently serves
as Editor of the following publications: Mycopathologia, Microbiology and Immunology, andBiological and Pharmaceutical Bulletin Case Report. In 2020, he received the Award of theJapanese Society for Medical Mycology.

Key points for achieving complete cure in the treatment of onychomycosis
Taisuke Ito, MD/PhD, Associate Professor, Department of Dermatology, Hamamatsu
University School of Medicine, Professor, Hamamatsu University Hospital, Shizuoka, JAPAN.
Dr. Ito graduated from the University of Occupational and Environmental Health, Japan andreceived his MD degree in 1995. He received his PhD in 2006 at Hamamatsu University
School of Medicine. In 2002 he served as Visiting Researcher at Department of Dermatology,
Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. He has been at Hamamatsu
University since 2006.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

109

Nobelpharma Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
07:00 – 08:00
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Therapeutic Effects of Topical Sirolimus on Skin Lesions in
Tuberous Sclerosis: Including clinical collaboration
CHAIRS:
Masatoshi Jinnin, MD/PhD, Professor, Department of Dermatology, Wakayama Medical
University, Wakayama, JAPAN.
Dr. Jinnin received his MD degree from Tokyo University, and his PhD degree from the
Department of Dermatology, Graduate School of Medicine, University of Tokyo. In 2014, hebecame an Associate Professor at Kumamoto University, and in 2017, a Professor in the
Department of Dermatology at Wakayama Medical University.

SPEAKER:Sei-ichiro Motegi, MD/PhD, Professor, Department of Dermatology, Gunma University
Graduate School of Medicine, Gunma, JAPAN.
Dr. Motegi received his MD and PhD degrees from Gunma University in 1999 and 2004,
respectively. He worked as a visiting fellow in the lab of Dr. Mark C Udey at the Dermatology
Branch of the National Cancer Institute from 2007 to 2011. He began as an Associate
Professor at Gunma University in 2017, and was appointed as a full Professor in 2020.

110

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Incyte Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
07:00 – 08:00
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

WELCOME AND INTRODUCTION:
Jim Lee, MD, Group Vice President, Head Inflammation and AutoImmunity at Incyte

Vitiligo pathophysiology and emerging treatments
Mehdi Rashighi Firoozabadi, MD, Assistant Professor, Department of Dermatology, Universityof Massachusetts T.H. Chan School of Medicine.
Dr. Rashighi is also associated with the Morningside Graduate School of Biomedical Sciences,
working with the Immunology and Microbiology Program, Interdisciplinary Graduate Program,
MD/PhD Program and Translational Science. Dr. Rashighi received his Medical Degreefrom the Tehran University of Medical Science in Medicine and Trained in Dermatology at
the University of Massachusetts in Cambridge Massachusetts. Research interests include
autoimmune connective tissues diseases (cutaneous lupus, dermatomyositis, morphea)
inflammatory skin diseases, Vitiligo, Alopecia Areata and translational research. Dr. Rashighi
is an author on numerous studies investigating the role of memory cells, melanocytes andother aspects of Vitiligo.

PANEL DISCUSSION AND AUDIENCE Q & A

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING111

Plenary Session 5––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
08:10–09:10
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Manabu Fujimoto, Dr. Luis Garza, Dr. Julien Seneschal
08:10-08:22

ORAL 201 [POSTER 1405]

Cellular and molecular characterization of sebaceous glandself-renewal and regeneration following complete genetic ablation
N. A. Veniaminova1, Y. Jia2, A. Hartigan1, T. Huyge1, S. Tsai1,
M. A. Grachtchouk1, S. Nakagawa3, A. Dlugosz1, 4, S. Atwood2,
S. Wong1, 4
1
Department of Dermatology, University of Michigan, Ann Arbor,
Michigan, United States, 2Department of Developmental and Cell
Biology, University of California Irvine, Irvine, California, United States,
3
Department of Pathology, University of Michigan, Ann Arbor, Michigan,
United States, 4Department of Cell and Developmental Biology, Universityof Michigan, Ann Arbor, Michigan, United States

08:22-08:34

ORAL 202 [POSTER 469]

Evidence of a causal relationship between stroke and psoriasis
R. Ramessur, J. Saklatvala, J. Barker, N. Dand, M. Simpson, C. Smith
King’s College London, London, United Kingdom

08:34-08:46

08:46-08:58

08:58-09:10

ORAL 205 [POSTER 1208]

Lactate and its induced EGR1 are novel key factors that determines
the inflamed or non-inflamed tumor status
H. Kanemaru1, 2, Y. Mizukami1, A. Kaneko1, T. Kimura1, H. Kuriyama1,
I. Kajihara1, S. Fukushima1
1
Department of Dermatology and Plastic Surgery, Kumamoto University,
Kumamoto, Japan, 2Department of Life Sciences, Imperial College
London, London, United Kingdom

ORAL 203 [POSTER 668]

Prevention of cardiovascular disease and mortality in patients withpsoriasis or psoriatic arthritis (CP3) study: Preliminary results
A. Neopaney5, S. Wang5, D. B. Shin5, R. Fitzsimmons5, S. Baez5,
A. Armstrong1, J. Barbieri2, R. Beidas4, M. Garshick3, N. Mehta6,
A. Ogdie5, J. Gelfand5
1
University of Southern California, Los Angeles, California, United States,
2
Harvard University, Cambridge, Massachusetts, United States, 3NYU
Langone Health, New York, New York, United States, 4Northwestern
University, Chicago, Illinois, United States, 5University of Pennsylvania,
Philadelphia, Pennsylvania, United States, 6George Washington
University, Washington, District of Columbia, United States

112

ORAL 204 [POSTER 851]

RNA therapy for congenital melanocytic naevi
D. Bryant1, 3, R. Maeshima3, W. Baird3, A. Sauvadet1, 3, C. Demetriou3,
D. Zecchin1, 3, S. Barberan-Martin1, 3, A. Pittman5, S. Polubothu3, 2,
L. Larue4, S. L. Hart3, V. A. Kinsler1, 2, 3
1
Mosaicism and Precision Medicine Lab, Francis Crick Institute, London,
United Kingdom, 2Great Ormond Street Hospital, London, United
Kingdom, 3UCL Institute of Child Health, London, United Kingdom,
4
Institut Curie, Orsay, France, 5St George’s University of London, London,
United Kingdom

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGSID Special Guest Lecture

The Evolution of Human Skin Pigmentation as a Long andComplex Biocultural Phenomenon––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
09:15 – 09:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Tissa Hata

Nina Jablonski, PhD
Pennsylvania State University
University Park, PA

Dr. Jablonski is a biological anthropologist who studies primate andhuman evolution, especially questions not answered directly from thefossil record such as the evolution of human skin and skin pigmentation.
She grew up in rural upstate She received an A.B. in Biology at Bryn Mawr
College and a Ph.D. in Anthropology at the University of Washington.
She has held academic positions at the University of Hong Kong, The
University of Western Australia, the California Academy of Sciences,
and The Pennsylvania State University. She is an elected Member of
the National Academy of Sciences and of the American PhilosophicalSociety, an elected Fellow of the American Academy of Arts andSciences and of the American Association for the Advancement of
Science, and is a recipient of an Alphonse Fletcher, Sr., Fellowship anda Guggenheim Fellowship. In addition to a large body of peer-reviewed
scientific papers, Jablonski has written two popular books for adults:
Skin: A Natural History (2006) and Living Color: The Biological and Social
Meaning of Skin Color (2012), as well as a book for children, Skin We Are
In (2018). A dedicated public scientist and science educator, Jablonski
received an honorary doctorate from the University of Stellenbosch inSouth Africa in 2010 for her contribution to the worldwide fight against
racism.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

113

ESDR Special Guest Lecture

Skin Myeloid Cell Heterogeneity––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
09:45 – 10:15
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Introduction by:
Dr. Hervé Bachelez

Florent Ginhoux, PhD
Singapore Immunology Network (SIgN),
A*STAR, Singapore

Florent Ginhoux obtained his PhD in 2004 from the University Pierre etMarie CURIE, Paris VI. As a postdoctoral fellow, he joined the Laboratoryof Miriam Merad in the Mount Sinai School of Medicine (MSSM), NewYork where he studied the ontogeny and the homeostasis of cutaneous
dendritic cell populations, with a strong focus on Langerhans cells andMicroglia.
In 2008, he became an Assistant Professor in the Department of Geneand Cell Medicine, MSSM and member of the Immunology Institute of
MSSM. He joined the Singapore Immunology Network (SIgN), A*STARin May 2009 as a Principal Investigator. He is a Web of Science Highly
Cited Researcher since 2016. He is also an Adjunct Visiting Associate
Professor in the Shanghai Immunology Institute, Jiao Tong University,in Shanghai, China since 2015 as well as Adjunct Associate Professor
in the Translational Immunology Institute, SingHealth and Duke NUS,
Singapore since 2018.
He is also starting a new laboratory focusing on pediatric cancers in the
INSERM unit 1015 in Gustave Roussy Hospital, Villejuif, France.

114

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGNovartis Pharma K.K. Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
10:20 – 11:50
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Reimagining Immuno-dermatology
Reimaging urticaria

Reimagining melanoma-2023

CHAIR:
Kenji Kabashima, MD/PhD, Professor andChair, Department of Dermatology, Kyoto
University Graduate School of Medicine

CHAIR:
Russell Hall, MD, J. Lamar Callaway
Professor of Dermatology, Departmentof Dermatology, Duke University Medical
Center

SPEAKER:SPEAKER:SPEAKER:

Marcus Maurer, MD, Professor of
Dermatology and Allergy and the executive
Director of the Institute of Allergology,
Charité – Universitätsmedizin

Victoria Atkinson, MD, Senior Medical
Oncologist, Greenslopes Private Hospital

Liv Eidsmo, MD/PhD, Professor ofTranslational Skin Immunology and the
Executive Director of the LEO Foundation
Skin Immunology Research Center,
University of Copenhagen

Prof Maurer is a Dermatologist andAllergologist, and he also trained inexperimental pathology at the Beth Israel
Deaconess Hospital and Harvard Medical
School in Boston (1995-1998); Board
certification for Dermatology (2000) andAllergology (2003). Assistant Professor
at the Allergie-Centrum-Charité at Charité– Universitätsmedizin Berlin (2004-2005).
Since 2005, full professor at Charité. Prof.
Maurer a coordinator of the Global Allergy
and Asthma European Networks of urticaria
and angioedema centers of reference andexcellence, UCARE and ACARE. His areasof clinical interest include angioedema,
urticaria, mastocytosis, pruritus, skininfections, and allergic diseases. His
research is focused on the biology of mast
cells, neuroimmunology, inflammation,
innate immunity and tolerance. He has
supervised more than 60 clinical trials,
phase 1 through 4. Prof. Maurer has
contributed to more than 600 publications
in peer-reviewed journals (>25.000
citations, H Index 79) and 40 books andbook chapters.

Professor Victoria Atkinson is a Medical
Oncologist from Brisbane, Australiapracticing at Greenslopes Private Hospitaland Princess Alexandra Hospital and heracademic affiliation is the University of
Queensland. Her interests are melanoma
and upper gastro-intestinal tumours. She
had been extensively involved in the trials
which have led to our modern managementof melanoma with both targeted therapy
and immunotherapy. She is extensively
published, and her publications include
co-authorship on 6 NEJM and 2 in Nature
Medicine.

Reimagining memory of skininflammation
CHAIR:
Yoshiki Tokura, MD/PhD, Director ofAllergic Disease Research Center, Directorof Department of Dermatology & Skin
Oncology, Chutoen General Medical Center

Professor Liv Eidsmo is a board certified
dermatologist, a Professor of Translational
Skin Immunology and the Executive Directorof the LEO Foundation Skin Immunology
Research Center at the University of
Copenhagen. Eidsmo graduated from
Karolinska Institutet, Sweden. Following
a postdoc in Frank Carbone's laboratory
at Melbourne University in Australia, her
first laboratory was established at theCenter for Molecular Medicine (CMM) at
Karolinska Institutet in parallel to clinicaltraining in dermatology at Karolinska
University Hospital. The research focuseson how T cells residing in the skin drive
local recurrence of diseases such as
psoriasis and vitiligo.

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

115

UCB Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
12:05 – 13:05
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Spotlight on Psoriasis: New Perspectives on Therapy
and Pathology
CHAIRS:
Akimichi Morita, MD/PhD, Professor and Chairman, Department of Geriatric andEnvironmental Dermatology, Nagoya City University Graduate School of Medical Sciences,
Nagoya, Japan
Christopher Griffiths, MD, Emeritus Professor of Dermatology, University of Manchester, UK

SPEAKERS:
Painting a Picture: The Therapeutic Landscape of Psoriasis
Yayoi Tada, MD/PhD, Professor and Chairman, Department of Dermatology, Teikyo University
School of Medicine , Tokyo, Japan
Dr. Tada earned her MD and PhD degrees from the University of Tokyo and completed her
residency under the Department of Dermatology. Dr. Tada also served as Chief of Departmentof Dermatology in Kosei Hospital before her current role in Teikyo University School of
Medicine as Chief Professor of the Department of Dermatology. She has authored morethan 180 peer-reviewed articles throughout her career, including her contributions as Section
Editor for the Journal of Dermatology and as a reviewer for various journals. Her researchinterest is skin inflammatory diseases, especially psoriasis and atopic dermatitis.

Straight Up: How Does the ‘Cytokine Cocktail’ Drive the Progression of Psoriasis?
James Krueger, MD/PhD, Laboratory for Investigative Dermatology, The Rockefeller
University, New York, NY, USA.
Dr. Krueger is Head of the Laboratory for Investigative Dermatology at The Rockefeller
University in New York, NY, USA. He also serves as Physician and Co-director of the Centerfor Clinical and Translational Science at the Rockefeller University Hospital, and as Chief
Executive Officer of the Rockefeller University Hospital. Dr Krueger earned his PhD degree invirology and cell biology from The Rockefeller University. He received his medical degree from
Cornell University Medical College (New York City), where he also completed an internship ininternal medicine and a residency in dermatology.

116

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGJanssen Pharmaceutical / Taiho Pharmaceutical Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
12:05 – 13:05
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Characteristics of Palmoplantar Pustulosis
CHAIRS:
Kazumitsu Sugiura, MD/PhD, Professor and Chairman, Department of Dermatology, Fujita
Health University School of Medicine, JAPANRiichiro Abe, MD/PhD, Professor and Chair, Department of Dermatology, Niigata University
Graduate School of Medical and Dental Sciences, JAPANSPEAKERS:
Characteristics of Japanese patients with palmoplantar pustulosis
Masamoto Murakami, MD/PhD, Professor, Department of Dermatology, Ehime University,
Gradutate School of Medicine, JAPAN.
Dr. Murakami received his MD degree from St. Marianna University, School of Medicine,
Kanagawa, and his PhD degree (Pathology in Medical Science), from Fujita Health University,
School of Medicine. He joined the Dept. of Dermatology at Ehime University Graduate Schoolof Medicine in 2012 as a Senior Assistant Professor, and was appointed as a full Professor
in 2021. His research focuses on the pathogenesis and new treatment developmentof palmoplantar pustulosis and pustular psoriasis; mechanisms of innate defense by
antimicrobial peptides, neutrophils, and macrophages; and skin bio-imaging.

Clinical characteristics and treatment status of palmoplantar pustulosis
Mitsumasa Kishimoto, MD/PhD, Associate Professor, Department of Nephrology andRheumatology, Kyorin University, School of Medicine, Tokyo, JAPAN.
After completing his training in Japan, he completed an Internal Medicine Residency
program at the University of Hawaii, and a Rheumatology Fellowship program at New York
University. In 2006 he took the role of Program Director of the Department of Rheumatology
at the Kameda Medical Center, then from 2009 to 2019, clinical program director in St Lukes
International hospital before moving on to accept his current position in 2019.Dr Kishimotowas certified by the American Board of Internal Medicine and Rheumatology and received an
ACR Distinguished Fellow Award in 2006.

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Mitsubishi Tanabe Pharma / Teikoku Seiyaku Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
12:05 – 13:05
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Itch Caused by Common Skin Disease
CHAIR:
Shinichi Sato, MD/PhD, Professor and Chair, Department of Dermatology, The University ofTokyo, Tokyo, JAPANSPEAKERS:
Mechanism and therapeutics of itch in atopic dermatitis
Saeko Nakajima, MD/PhD, Department of Drug Discovery for Inflammatory Skin Diseases,
Kyoto University Graduate School of Medicine, Kyoto, JAPAN.
Dr. Nakajima received her MD degree from Osaka Medical College in 2003, and her PhD
degree from Kyoto University, Graduate School of Medicine in 2012. She completed a
Research Fellowship for Young Scientists of Japan Society for the Promotion of Science,
Department of Dermatology, Kyoto University Graduate School of Medicine, and served asa Visiting Fellow, Mucosal immunology section, Laboratory of parasitic diseases, National
Institute of Allergy and Infectious Diseases, National Institutes of Health in the US.

Pruritus in Urticaria Management
Naoko Inomata, MD/PhD, Chief Professor, Department of Dermatology, Showa University
School of Medicine, Tokyo, JAPAN.
Dr. Inomata began her career as a resident at Kanagawa children medical center, Kanagawa,Japan in 1994. She joined Yokohama City University of Medicine, Dept of Dermatology,
Kanagawa as a medical doctor 1997-1998 and also acted as a medical doctor at the
Yokohama Red Cross hospital, Kanagawa, Japan 1998-2000. She was named an AssistantProfessor at Yokohama City University of Medicine, Dept of Dermatology in 2001, and waspromoted to Associate Professor in 2012. Dr. Inomata completed a Visiting Fellowship at
the Allergy Transcriptome Unit at the Research Center for Allergy and Immunology, RIKEN, in2003. She became faculty as Chief Professor at Showa University School of Medicine, Deptof Dermatology, Tokyo, Japan, in 2021.

118

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGThe Estée Lauder Companies Inc. Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
12:05 – 13:05
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––

Skin Barrier Function and Approaches for Improving Innate
Hydration of Skin
CHAIR:
Kenji Kabashima, MD/PhD, Professor and Chair, Department of Dermatology, Kyoto
University Graduate School of Medicine, Kyoto, JAPAN. Dr. Kabashima’s research focuseson understanding the underlying mechanisms of inflammatory skin diseases such as atopic
dermatitis, contact dermatitis, and psoriasis, as well as exploring 3D visualization of the skinusing two-photon microscopy and drug development.

SPEAKERS:
Moisturize your skin by the skin innate hydration
Teruki Dainichi, MD/PhD, Professor and Chair, Department of Dermatology, Kagawa
University Faculty of Medicine, Miki, JAPAN.
Dr. Dainichi received both his MD, and PhD degrees from Tokushima University Schoolof Medicine, Tokushima, JAPAN. His current research interest includes the study of theEpithelial–immune microenvironment (EIME), Bullous disease, and Alopecia.

New moisturizing ingredient for improving skin’s innate hydration - Rice Power™ #11α
Yuichi Miyoshi, PhD, Researcher, R&D-Yushin Brewer Co., Ltd., Kagawa, JAPAN.
Dr. Miyoshi received his PhD from the Department of Engineering, Graduate school of Natural
Science and Technology, Okayama University, Okayama, JAPAN.

In vitro/in vivo proven superior hydration benefits of Rice Power™ #11α containing
formulations
Richard Cao, PhD, Senior Director, APAC Advanced Technologies, ELC, Shanghai, CN.
Dr Cao holds a PhD in Materials Science with a strong background in biopolymers, colloids
and interface science, microstructure materials, bio-actives etc. He has accumulated nearly
19 years of R&D experience in developing breakthrough technologies for the applications inhome and personal care products, cosmetics, foods etc in multi-international companies. He
has authored over 20 peer-reviewed publications and has been the inventor of over 15 patentapplications in related fields.

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SUN Pharma Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
12:05 – 13:05
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––How to apply genetic information to autoimmune research
CHAIR:
Shinji Shimada, MD/PhD, Executive Adviser, University of Yamanashi, Yamanashi, JAPANSPEAKER:
Kazuhiko Yamamoto, MD/PhD, Director, RIKEN Center for Integrative Medical Sciences,
Kanagawa, JAPAN.
Dr. Yamamoto graduated from the University of Tokyo School of Medicine in 1977. After
finishing his training and residency in internal medicine and rheumatology, he conducted basic
research in the laboratory of Prof T. Tada in Tokyo and Prof G. Haemmerling in Heidelberg.
In 1985, he started his own research projects and also served as clinical rheumatologist in
the University of Tokyo Hospital. He then moved to Medical Institute of Bioregulation, Kyushu
University as a professor. In 1997, he was promoted to be the professor and chairman of
Department of Allergy and Rheumatology, the University of Tokyo Graduate School of Medicine.
In 2017, he reached the mandatory retirement age of the University of Tokyo and moved to
RIKEN Center for Integrative Medical Sciences as a deputy director. In 2020, he become thedirector. He is also an emeritus professor of the University of Tokyo. Dr. Yamamoto’s researchinterests include genetic and functional genetic analyses of autoimmune diseases. He is now
planning to establish a research system of human immunology in the research center.

120

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGProcter & Gamble Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
12:05 – 13:05
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––A Novel Approach in Understanding Skin Leveraging
Spatial Biology
In vivo skin imaging: towards non-invasive skin biopsy
Gyohei Egawa, MD/PhD, Lecturer, Department of Dermatology, Kyoto University, Japan.
Dr. Egawa graduated from Saga Medical University in 2001 and worked as a research fellow
on a drug discovery project for atopic dermatitis and studied at the Centenary Institute inAustralia before taking up his current position. He specializes in skin immunology and is anexpert in skin imaging research. ”Observation-based research" is his research motto.

Spatial Analysis via Single-Cell RNA Sequencing: Galactomyces Ferment Filtrate’s Efficacy
on Human Epidermis
Satoshi Nakamizo MD/PhD, Program-Specific Junior Associate Professor in Alliance
Laboratory for Advanced Medical Research, Kyoto University Graduate School of Medicine,Japan. Dr. Nakamizo graduated from Saga Medical University in 2007 and completed his
PhD at Kyoto University School of Medicine, before studying at the Agency for Science,
Technology and Research (A*STAR) in Singapore. He specializes in skin immunology and is
an expert in single-cell RNA sequencing of skin cells.

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Concurrent Mini-Symposium 13

Cell-Cell Interactions in the Skin

Studies on cell-cell interactions between specific skin cell types (including but not limited to keratinocytes, nerves (neuro-cutaneous
biology), melanocytes, fibroblasts, adipocytes, immune cells and progenitors) in the skin and their local cellular and extracellularenvironments that affect skin inflammation, sensation (e.g., itch and pain), signaling, adhesion, migration, development andhomeostasis.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Tetsuya Honda, Dr. Maria Morasso, Dr. Rachel Watson

13:15-13:25

ORAL 206 [POSTER 355]

Sensory neuronal STAT3 is critical for IL-31 receptor expression andinflammatory itch
S. Takahashi1, S. Ochiai1, T. Okada1, 2
1
Rikagaku Kenkyujo Yokohama Campus, Yokohama, Kanagawa, Japan,
2
Yokohama Shiritsu Daigaku, Yokohama, Kanagawa, Japan

13:25-13:35

ORAL 207 [POSTER 319]

13:55-14:05

ORAL 210 [POSTER 363]

Elevated expression of CCN1 in dermal fibroblasts causes accelerated
dermal aging and promotes keratinocyte carcinogenesis
T. Quan, A. Kim, C. Guo, Y. Xiang, Z. Qin, Y. Liu, Y. Yan, A. Ermilov,
J. J. Voorhees, A. Dlugosz, G. J. Fisher
Dermatology, University of Michigan, Ann Arbor, Michigan, United States

14:05-14:15

ORAL 211 [POSTER 351]

Single-cell analysis of immune system interactions in the basal cell
carcinoma tumor microenvironment
Q. N. Wong, S. Atwood
Developmental and Cell Biology, University of California Irvine, Irvine,
California, United States

Spatial transcriptomics and single-cell transcriptomics elucidates
the intricate inflammatory cellular network in atopic dermatitis
Y. Mitamura1, M. Reiger2, J. Kim1, Y. Xiao1, D. Zhakparov1, B. Rückert1,
P. Brunner3, D. Roqueiro4, C. Traidl-Hoffmann2, C. Akdis1
1
Universitat Zurich Schweizerisches Institut fur Allergie-undAsthmaforschung, Davos, Switzerland, 2Department of Environmental
Medicine, Faculty of Medicine, Universitat Augsburg, Augsburg, Bayern,
Germany, 3Department of Dermatology, Icahn School of Medicine
at Mount Sinai, New York, New York, United States, 4Department of
Biosystems Science and Engineering, ETH-Bereich Hochschulen, Zurich,
Zürich, Switzerland

Transcriptomic analysis indicates that loss of epidermal Pparg
promotes TLR4 signaling and significant overlap with the NMSC
transcriptome
R. L. Konger1, X. Xuei2, H. Gao2
1
Pathology, Indiana University School of Medicine, Indianapolis, Indiana,
United States, 2Medical & Molecular Genetics, Indiana University Schoolof Medicine, Indianapolis, Indiana, United States

13:35-13:45

14:25-14:35

ORAL 208 [POSTER 349]

Propionate alleviates itch in atopic dermatitis by modulating sensory
TRP channels of dorsal root ganglion
Y. Xu1, X. Yao2, W. Li1
1
Department of Dermatology, Huashan Hospital Fudan University,
Shanghai, China, 2Affiliated Hospital for Skin Diseases of Chinese
Academy of Medical Sciences, Nanjing, Jiangsu, China

14:15-14:25

ORAL 209 [POSTER 338]

Extracellular matrix (ECM) remodeling in atopic dermatitis (AD) as aputative contributor to the atopic march
D. S. Wörz1, P. Graff3, T. Blimkie2, P. Panwar5, D. Brömme5,
R. E. Hancock2, S. Hedtrich1, 41Berlin Institute of Health at Charite, Berlin, Germany, 2The University of
British Columbia Centre for Microbial Diseases and Immunity Research,
Vancouver, British Columbia, Canada, 3Freie Universitat Berlin Institut fur
Pharmazie, Berlin, Germany, 4The University of British Columbia Facultyof Pharmaceutical Sciences, Vancouver, British Columbia, Canada, 5The
University of British Columbia Faculty of Dentistry, Vancouver, British
Columbia, Canada

ORAL 213 [POSTER 359]

Pansclerotic morphea is characterized by type II IFN responses
priming T cell – cDC2b – fibroblast crosstalk to promote fibrosis
E. Xing, F. Ma, A. Billi, M. Gharaee-Kermani, J. M. Kahlenberg,
R. Wasikowski, L. Tsoi, D. Khanna, J. Gudjonsson
University of Michigan, Ann Arbor, Michigan, United States

14:35-14:45
13:45-13:55

ORAL 212 [POSTER 323]

ORAL 214 [POSTER 336]

NET-associated DLL4 activates notch- γ secretase signaling inmacrophages and fibroblasts and promotes pro-fibrotic responses inhidradenitis suppurativa
C. Carmona-Rivera1, C. B. Oliveira1, J. Tena-Romo1, E. PatinoMartinez1, A. Woo1, A. Byrd2, G. Okoye2, M. Kaplan1
1
Systemic Autoimmunity Branch, National Institute of Arthritis andMusculoskeletal and Skin Diseases, Bethesda, Maryland, United States,2
Dermatology, Howard University College of Medicine, Washington,
District of Columbia, United States

Continued on next page.

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1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 13 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:45-14:55

ORAL 215 [POSTER 347]

A machine learning analysis enables demonstration that fibroblasts
mediate neutrophil recruitment during type 17 skin inflammation
K. Cavagnero, T. Dokoshi, A. O’Neill, T. Nakatsuji, F. Li, R. L. Gallo
Dermatology, University of California San Diego, La Jolla, California,
United States

14:55-15:05

ORAL 219 [POSTER 350]

Increased LL37 in patients with psoriasis and rosacea promotes theuptake of low-density lipoprotein and development of atherosclerosis
Y. Nakamura1, N. Kulkarni1, T. Dokoshi1, E. W. Luo2, H. Alimohamadi2,
G. C. Wong2, R. L. Gallo1
1
Dermatology, University of California San Diego, La Jolla, California,
United States, 2Bioengineering, University of California Los Angeles, Los
Angeles, California, United States

ORAL 216 [POSTER 327]

The early reactivation of resident CD8+ memory t cells depends oncross-presentation of antigen by langerhans cells in the epidermis
N. Kamenjarin1, 2, K. Hodapp1, 2, F. Melchior1, 2, G. Harms2, 3, V. Raker4,
C. Becker4, A. Brand2, 5, B. Clausen2, 5, H. Probst1, 2
1
Institute of Immunology, Universitatsmedizin der Johannes GutenbergUniversitat Mainz, Mainz, Rheinland-Pfalz, Germany, 2Research Center
for Immunotherapy, Universitatsmedizin der Johannes GutenbergUniversitat Mainz, Mainz, Rheinland-Pfalz, Germany, 3Cell Biology Unit,
Universitatsmedizin der Johannes Gutenberg-Universitat Mainz, Mainz,
Rheinland-Pfalz, Germany, 4Department of Dermatology, Westfalische
Wilhelms-Universitat Munster, Münster, Nordrhein-Westfalen, Germany,
5
Institute for Molecular Medicine, Universitatsmedizin der Johannes
Gutenberg-Universitat Mainz, Mainz, Rheinland-Pfalz, Germany

15:05-15:15

15:25-15:35

15:35-15:45

ORAL 220 [POSTER 365]

Axon growth inhibitory molecule nogo regulates epidermal
innervation by sensory neurons
A. Matsuyama, T. Okada
Center for Integrative Medical Sciences, Rikagaku Kenkyujo Yokohama
Campus, Yokohama, Kanagawa, Japan

ORAL 217 [POSTER 361]

p120-catenin regulates epidermal inflammation in a cadherindependent manner
T. Seo, H. Xu, M. Sennett, S. L. Schell, A. M. Nelson, A. P. Kowalczyk
Dermatology, Penn State College of Medicine, Hershey, Pennsylvania,
United States

15:15-15:25

ORAL 218 [POSTER 373]

Identification of immune cell pathways in acne vs. rosacea by singlecell RNA sequencing and single-cell spatial imaging
T. H. Do1, 2, J. Perrie2, M. Pellegrini2, J. Gudjonsson3, F. Ma3,R. L. Modlin2
1
Stony Brook Southampton Hospital, Southampton, New York, UnitedStates, 2University of California Los Angeles, Los Angeles, California,
United States, 3University of Michigan, Ann Arbor, Michigan, UnitedStates

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Concurrent Mini-Symposium 14

Clinical Research – Socio-behavioral and Health Services
Research/Clinical Research-Interventional ResearchSocio-behavioral studies may include, but are not limited to, studies of patient and/or provider behaviors and attitudes towards diseases, treatments, diagnostic andscreening tests, and health care delivery. Health services research studies may include, but are not limited to, studies of access, use, delivery, quality, and cost-effectivenessof dermatologic care/Interventional human trials that evaluate or compare therapies, devices, or other interventions for the treatment of skin diseases. This may include
systematic reviews and/or meta-analyses of interventional studies.

––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Soyun Cho, Dr. Scott Worswick, Dr. Liat Samuelov

13:15-13:25

ORAL 221 [POSTER 690]

Trends in topical steroids spending and potential savings: An analysis
of United States Medicare part D from 2011 to 2020
S. Ly1, 2, P. Manjaly1, K. Kamal1, A. Mostaghimi11Dermatology, Brigham and Women’s Hospital, Boston, Massachusetts,
United States, 2University of Arkansas for Medical Sciences College ofMedicine, Little Rock, Arkansas, United States

14:05-14:15

ORAL 226 [POSTER 597]Interim results of a phase I/II, closed label, randomized pilot study forthe safety and efficacy of TolaSure gel, 5% w/w targeting aggregatedmutant keratin in severe epidermolysis bullosa simplex (TAMES)
A. N. Johnson1, K. McGuire2, A. McCormick2, K. E. Rieger1,
L. Broadwater2, S. Jain1, L. Perrone1, J. M. Teng1, J. Y. Tang1,
A. S. Chiou1
1
Dermatology, Stanford University School of Medicine, Stanford,
California, United States, 2BioMendics, LLC, Rootstown, Ohio, UnitedStates14:15-14:25
13:25-13:35

ORAL 222 [POSTER 683]

Loneliness, stress, and discrimination in patients with and without
acne: A cross-sectional study
W. Perry1, 2, S. Tushe2, H. Yeung2
1
Emergency Medicine, Emory University School of Medicine, Atlanta,
Georgia, United States, 2Dermatology, Emory University School of
Medicine, Atlanta, Georgia, United States

ORAL 227 [POSTER 626]

Clinical trial of bacteriotherapy as antibiotic-sparing therapy for acne
vulgaris
E. S. Burger, S. Brinton, A. O’Neill, T. Nakatsuji, F. Shafiq, O. C. Osuoji,
T. Hata, R. L. Gallo
Dermatology, University of California San Diego, La Jolla, California,
United States

14:25-14:35
13:35-13:45

ORAL 223 [POSTER 586]

Increase in CD8+ effector memory cells re-expressing CD45RA(TEMRA) reflects disease activity and enables early prediction oftherapeutic outcome in rapidly progressive alopecia areata
R. Takahashi1, M. Kinoshita-Ise2, Y. Sato2, M. Kimishima2,
M. Ohyama1, 2
1
Flow Cytometry Core Facility, Kyorin University Graduate School of
Medicine, Mitaka, TOKYO, Japan, 2Department of Dermatology, Kyorin
University Faculty of Medicine, Mitaka, TOKYO, Japan

13:45-13:55

ORAL 224 [POSTER 689]

Tiktok and dermal fillers: A cross-sectional study on dermal
filler-related content quality
H. de Baun1, P. E. Cerri-Droz1, S. Khan2, B. Rao2
1
Stony Brook University Renaissance School of Medicine, Stony Brook,
New York, United States, 2Rutgers Robert Wood Johnson Medical
School, Piscataway, New Jersey, United States

13:55-14:05

ORAL 225 [POSTER 646]

IFN-α therapy of peritoneal carcinosis induces senescence inmetastatic melanoma cells
E. Brenner, T. Wieder, H. Braumüller, C. Boß, C. Schulz, S. Kayser,
M. Röcken
Eberhard-Karls-Universitat Tubingen Medizinische Fakultat, Tubingen,Baden-Württemberg, Germany

ORAL 228 [POSTER 621]

Topical simvastatin for porokeratosis ptychotropica: A randomized,
single-blind, split-body, placebo-controlled investigator-initiatedtrial
Z. Chen, Y. Liu, H. Yu, H. Chen, Y. Yang
Affiliated Hospital for Skin Diseases of Chinese Academy of Medical
Sciences, Nanjing, Jiangsu, China

14:35-14:45

ORAL 229 [POSTER 693]

Social media as an educational platform for seborrheic dermatitis
S. Fakhraie, R. Chovatiya
Dermatology, Northwestern University Feinberg School of Medicine,
Chicago, Illinois, United States

14:45-14:55

ORAL 230 [POSTER 691]

Visualization of Covid-19 pandemic influence on healthcare routines
in dermatology using electronic health record data
J. Ryan Wolf1, L. Zhang2, Y. Xie3, A. Pentland1, B. T. Pentland2
1
Dermatology, University of Rochester Medical Center, Rochester, New
York, United States, 2College of Business, Michigan State University, East
Lansing, Michigan, United States, 3Public Health Sciences, University ofRochester Medical Center, Rochester, New York, United States

14:55-15:05

ORAL 231 [POSTER 692]

Impact of education on illness perception in patients with cutaneous
T-cell lymphoma
A. Munjal, O. Pierog, D. Weiner, S. Talluru, A. Burns, S. Rozati
Dermatology, Johns Hopkins University, Baltimore, Maryland, UnitedStatesContinued on next page.

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1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 14 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM B: EMINENCE HALL, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
15:05-15:15

ORAL 232 [POSTER 587]

Higher IL-10+ T cell and treg cell counts in psoriatic skin areassociated with super-response to guselkumab: Data from the phase
3 guide trial
J. Angsana6, K. Kohler6, J. Sendecki6, M. W. Leung6, S. Tabori7,
N. Krüger7, S. Wegner7, Y. Personke7, R. Sabat2, K. Wolk2, A. Pinter1,
P. Weisenseel3, K. Asadullah2, 8, K. Schäkel4, K. Eyerich5
1Uni. Hosp. Frankfurt am Main, Frankfurt am Main, Germany, 2Charité–
Universitätsmedizin Berlin, Berlin, Germany, 3Dermatologikum Hamburg,
Hamburg, Germany, 4Heidelberg Uni. Hosp., Heidelberg, Germany, 5Med.
Center, Uni. of Freiburg, Freiburg, Germany, 6Janssen R&D LLC, San
Diego, California, United States, 7Janssen-Cilag GmbH, Neuss, Germany,
8
Dermatological practice, Potsdam, Germany

15:15-15:25

ORAL 233 [POSTER 590]

Litifilimab modulates Type 1 interferon (IFN) biomarkers in patientswith cutaneous lupus erythematosus (CLE): Result of the LILAC PartB Phase 2 study
V. P. Werth1, R. A. Furie2, E. Milliman3, K. Ferber3, F. Casey3,
R. Brown3, D. Raitcheva3, J. Zoghbi3, D. Graham3, G. Kong3, Y. Lahoud3,
N. Franchimont3, C. Barbey4
1
University of Pennsylvania, Philadelphia, Pennsylvania, United States,
2
Northwell Health, Great Neck, New York, United States, 3Biogen,Cambridge, Massachusetts, United States, 4Biogen, Baar, Switzerland

15:25-15:35

ORAL 234 [POSTER 669]

Examining disparities in melanoma detection: A geospatial analysisof access-to-care
M. M. Tran, T. Vance, S. Yumeen, L. Orsillo, F. N. Mirza, A. Robbins,
A. Mehta, O. Wisco
Dermatology, Brown University Warren Alpert Medical School,
Providence, Rhode Island, United States

15:35-15:45

ORAL 235 [POSTER 624]

Clinical and immune analysis of mesenchymal stromal cells (MSCs)
for multiple biologic-resistant psoriasis
S. M. Lwin, S. Solanky, I. Tosi, H. Dawe, J. A. McGrath, C. Giacomini,
P. di Meglio, F. Dazzi, C. E. Griffiths
King’s College London, London, United Kingdom

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Concurrent Mini-Symposium 15

Epidermal Structure and Barrier Function

Research on the components or regulation of keratinocyte proliferation, differentiation, including epidermal barrier maintenanceand function.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Hideyuki Ujiie, Dr. Tatiana Efimova, Dr. Sandrine Dubrac

13:15-13:25

ORAL 0236 [POSTER 766]

H3K9me3 methyltransferase SETDB1 controls retrotransposon
silencing,DNA
methylation,
constitutive
heterochromatin
maintenance and 3D-chromatin structure in epidermal keratinocytes
E. Rozhkova1, G. Chen1, L. Yang2, N. Lau3, V. A. Botchkarev1, A. Sharov1
1
Dermatology, Boston University, Boston, Massachusetts, UnitedStates, 2University of Washington, Seattle, Washington, United States,
3
Biochemistry, Boston University, Boston, Massachusetts, UnitedStates13:25-13:35

13:55-14:05

ORAL 0240 [POSTER 738]

Cryo-EM and molecular dynamics of TRPV3 channel in activatedstate reveal structural features implicated in severe itch andhyperkeratosis
F. Chin1, F. Qin2
1
University of Pennsylvania Perelman School of Medicine, Philadelphia,
Pennsylvania, United States, 2Department of Physiology and Biophysics,
State University of New York at Buffalo, Buffalo, New York, United States

14:05-14:15

ORAL 0241 [POSTER 750]

Epidermal expression of Hes1 controls immune response
M. Wakatake, M. Moriyama, S. Goto, Y. Miyake, H. Moriyama
Kinki Daigaku, Higashi-Osaka, Japan

ORAL 0237 [POSTER 737]

The role of bisphenol A in atopic dermatitis
D. C. Minzaghi1, V. Cerkvenik Flajs2, S. Dubrac1
1
Department of Dermatology, Venereology and Allergology, innsbruck
medical university, Innsbruck, Austria, 2Institute of Pathology, Wild
Animals, Fish and Bees, Veterinary Faculty, University of Ljubljana,
Slovenia, Ljubljana, Slovenia

13:35-13:45

ORAL 0238 [POSTER 775]

A secretome CRISPR screen identifies SFRP1 and other extracellular
proteins regulating epidermal homeostasis
B. Cheng1, T. Bencomo2, C. S. Lee2, B. Sun1
1
Dermatology, University of California San Diego, La Jolla, California,
United States, 2Dermatology, Stanford University School of Medicine,
Stanford, California, United States

13:45-13:55

ORAL 0239 [POSTER 745]

Gasdermin a guards epidermal differentiation and cornification inskin barrier repair: Its role in atopic dermatitis pathogenesis
L. Huang1, S. Li1, S. Lin1, C. Kao5, C. Hong3, 4, C. Lee2, L. Yang1, 6
1
Institute of Cellular and System Medicine, National Health ResearchInstitutes, Zhunan, Miaoli County, Taiwan, 2Chang Gung University
College of Medicine, Kaohsiung Chang Gung Memorial Hospital,
Kaohsiung, Taiwan, 3Department of Dermatology, Kaohsiung Veterans
General Hospital, Kaohsiung, Taiwan, 4Department of Dermatology,
National Yang Ming Chiao Tung University School of Medicine, Taipei,
Taiwan, 5Center of General Education, Chang Gung University, Taoyuan,
Taiwan, 6Graduate Institute of Biomedical Sciences, China Medical
University, Taichung, Taiwan

14:15-14:25

ORAL 0242 [POSTER 783]

Epidermal-specific ablation of CD271 is linked to altered proliferationand differentiation of keratinocytes during postnatal mouse skindevelopment
M. Quadri1, C. Pellegrini2, M. Mastrangelo2, M. Fargnoli2, C. Vaschieri1,
M. Canossa3, M. I. Morasso4, R. Lotti1, C. Pincelli1, A. Marconi1,
E. Palazzo1
1
DermoLab, University of Modena and Reggio Emilia, Modena, Italy,
2
University of L’Aquila, L’Aquila, Italy, 3CIBIO, University of Trento, Trento,
Italy, 4Lab Skin Biology, National Institutes of Health, Bethesda, Maryland,
United States

14:25-14:35

ORAL 0243 [POSTER 772]

Structure of a novel endoplasmic reticulum-desmosome complex
N. Bharathan1, W. Giang1, J. Aaron3, S. Khuon3, T. Chew3, A. Weigel3,
S. Saalfeld3, W. Vogl2, S. N. Stahley1, A. P. Kowalczyk1
1
Dermatology, Penn State College of Medicine, Hershey, Pennsylvania,
United States, 2Cellular & Physiological Sciences, The University of
British Columbia, Vancouver, British Columbia, Canada, 3Howard Hughes
Medical Institute Janelia Farm Research Campus, Ashburn, Virginia,
United States

14:35-14:45

ORAL 0244 [POSTER 697]

The overexpression of sphingomyelin deacylase in murine epidermis
elicits a ceramide deficiency and provokes atopic dermatitis-like skineruptions
M. Kimura1, M. Takada2, M. Komine1, H. Tsuda3, M. Ohtsuki1,
G. Imokawa2
1
Dermatology, Jichi Ika Daigaku, Shimotsuke, Tochigi, Japan,
2
Utsunomiya Daigaku, Utsunomiya, Tochigi, Japan, 3Division of Human
Genetics Center for Molecular Medicine, Jichi Ika Daigaku, Shimotsuke,
Tochigi, Japan

Continued on next page.

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Concurrent Mini-Symposium 15 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM C: NISHIKI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:45-14:55

ORAL 0245 [POSTER 723]

Common and different roles of dermokine in skin diseases based onmouse genetic backgroundK. Kawate, T. Shimizu, T. Chino, N. Oyama, M. Hasegawa
Department of Dermatology, Fukui Daigaku Igakubu, Yoshida-gun, Fukui,Japan

14:55-15:05

ORAL 0246 [POSTER 751]

Regulation of epidermal homeostasis by centrosomal protein Cep43
C. C. Yokoyama1, M. Colonna2
1
Internal Medicine, Division of Dermatology, Washington University in
St Louis, St Louis, Missouri, United States, 2Pathology & Immunology,
Washington University in St Louis, St Louis, Missouri, United States

15:05-15:15

15:35-15:45

ORAL 0250 [POSTER 797]

Crosstalk between adherens junctions and desmosomes andassociated cytoskeletons controls epidermal adhesion dynamics andmechanical resilience
H. Zhang1, M. Ruebsam1, R. Püllen2, K. Green3, R. Merkel2,
B. Hoffmann2, S. Wickström4, 5, C. M. Niessen1
1
Cell Biology of the Skin and CECAD, Universitat zu Koln, Koln, NordrheinWestfalen, Germany, 2Institute of Biological Information Processing, IBI2: Mechanobiology, Forschungszentrum Julich GmbH, Julich, NordrheinWestfalen, Germany, 3Departments of Pathology and Dermatology,
Northwestern University Feinberg School of Medicine, Chicago, Illinois,
United States, 4Department of Cell and Tissue Dynamics, Max Planck
Institute for Molecular Biomedicine, Münster, Germany, 5Stem Cells andMetabolism Research Program, Helsingin yliopisto Laaketieteellinen
tiedekunta, Helsinki, Uusimaa, Finland

ORAL 0247 [POSTER 774]

Receptor tyrosine kinase EPHA2 is required for epidermal barrier
homeostasis
B. Shi, T. Selph, K. Russell, T. Mahi, E. Khan, I. Martinez, G. SinchiPaucar, M. Liu, H. Peng, B. E. Perez White
Northwestern University, Chicago, Illinois, United States

15:15-15:25

ORAL 0248 [POSTER 749]

TNF-α promotes psoriasis-related keratinocytes dedifferentiation
through dual regulation of YAP and NOTCH1 signaling
Z. Yu1, Y. Shi2
1
Shanghai Tenth People’s Hospital, Shanghai, China, 2Shanghai Skin
Diseases Hospital, Shanghai, China

15:25-15:35

ORAL 0249 [POSTER 796]

Actin dependent regulation of epidermal differentiation and barrier
formation
M. Ruebsam1, A. Bhosale1, F. Tellkamp2, T. Matsui3, M. Amagai4,
M. Krüger2, C. M. Niessen1
1
Department Cell Biology of the Skin & CECAD, Universitat zu Koln, Köln,
Nordrhein-Westfalen, Germany, 2Institute for Genetics, Universitat zu
Koln, Köln, Nordrhein-Westfalen, Germany, 3School of Bioscience andBiotechnology, Tokyo Koka Daigaku, Hachioji, Tokyo, Japan, 4Departmentof Dermatology, Keio University School of Medicine, Tokyo, Japan

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Concurrent Mini-Symposium 16

Innate Immunity, Microbiology, Microbiome II

Studies of cells, receptors and effector molecules of the innate immune response; studies on skin microbes, microbiome andinfectious processes of the skin.
––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Nan-Lin Wu, Dr. Anna De Benedetto, Dr. Bernhard Homey

14:15-14:25

ORAL 0257 [POSTER 945]

A metabolite produced by skin commensal bacteria enhances
epithelial integrity in human keratinocyte
F. A. Aldehalan, A. J. Mcbain, C. O’Neill
The University of Manchester Faculty of Biology Medicine and Health,
Manchester, United Kingdom

Galectin-12 Regulates the Immune Response in Skin ThroughSebaceous Glands
F. Lin1, 2, Y. Huang1, 2, Y. Lo4, F. Liu1, 2, 3
1
Graduate Institute of Immunology, National Taiwan University, Taipei,
Taiwan, 2Institute of Biomedical Sciences Academia Sinica, Taipei,
Taiwan, 3University of California Davis Department of Dermatology,
Sacramento, California, United States, 4Fu Jen Catholic University,
Taipei, Taiwan

13:25-13:35

14:25-14:35

13:15-13:25

ORAL 0251 [POSTER 960]

ORAL 0252 [POSTER 956]

Epidermal keratinocyte-specific STAT3 deficiency aggravated atopic
dermatitis-like skin inflammation in mice through TSLP upregulation
Z. Wang, X. Man
Second Affiliated Hospital of Zhejiang University School of Medicine,
Hangzhou, China

13:35-13:45

ORAL 0253 [POSTER 966]

Cx26 mutation in keratinocytes is responsible for susceptibility
to candida albicans in the mouse model of keratitis-ichthyosisdeafness syndrome
A. Mostafa1, T. Murata2, H. Doi1, G. Egawa1, K. Kabashima1
1Dermatology, Graduate School of Medicine Kyoto University, Kyoto,
Japan, 2Dermatology, Hyogo Medical University, Nishinomiya, Japan

13:45-13:55

ORAL 0258 [POSTER 923]

Microbially-induced transgenerational epigenetic inheritance via theimmune system regulates sebum secretion and the chemical barrier
J. Harris1, 2, N. Trigg3, B. Goshu1, C. Conine3, E. Grice2, T. Kambayashi1
1
Pathology and Laboratory Medicine, University of Pennsylvania
Perelman School of Medicine, Philadelphia, Pennsylvania, United States,2
Dermatology, University of Pennsylvania Perelman School of Medicine,Philadelphia, Pennsylvania, United States, 3Neonatology, Children’s
Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

14:35-14:45

ORAL 0259 [POSTER 977]

IL-23/IL23R promote macrophage pyroptosis and Th1/Th17 celldifferentiation in mycobacterial infection
C. Wang, T. Liu, Z. Wang, Q. Zhao, Z. Mi, H. Liu, F. Zhang
Shandong Provincial Hospital for Skin Diseases & Shandong Provincial
Institute of Dermatology and Venereology, Jinan, China

ORAL 0254 [POSTER 983]

Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic
stress and NLRP1 inflammasome activation in a model of cutaneous
diphtheria
K. Robinson1, G. Toh2, K. Tham1, J. E. Common1, F. Zhong2
1
ASRL, Singapore, Singapore, 2NTU, Singapore, Singapore

13:55-14:05

ORAL 0255 [POSTER 917]

Amphiregulin-producing innate lymphoid cells promote barrier
response after mechanical damage
T. Kobayashi1, M. Li2, D. Asanuma3, N. Shigeyuki3, K. Hirose3,
K. Fujita2, K. Moro1,2
1
RIKEN, Yokohama, Japan, 2Osaka University, Osaka, Japan, 3Tokyo
University, Tokyo, Japan

14:05-14:15

ORAL 0256 [POSTER 939]

Acid mantle of the stratum corneum is a shield against bacterial entry
into the underlying epidermal layers
Y. Ito1, K. Fukuda2, R. Ozawa1, M. Amagai1, 2
1
Dermatology, Keio University School of Medicine, Tokyo, Japan, 2Skin
Homeositasis, RIKEN IMS, Yokohama, Japan

14:45-14:55

ORAL 0260 [POSTER 926]

The role of HTR2A on langerhans cells in skin inflammation
Y. Tan1, 4, C. Yeh4, S. Su4, C. Lu4, C. Tsai4, H. Weng2, 3, T. Tsai2, Y. Lee1, 41National Yang Ming Chiao Tung University – Yangming Campus, Taipei,
Taiwan, 2National Taiwan University Hospital, Taipei, Taiwan, 3Taipei
Medical University, Taipei, Taiwan, 4Institute of Biomedical Sciences,
Academia Sinica, Taipei, Taiwan

14:55-15:05

ORAL 0261 [POSTER 981]

Adiponectin downregulation in lesional skin contributes to enhanced
mTORC1 activation and skin inflammation in rosacea.
J. Suh4, 1, 2, S. Jin4, 1, 2, Y. Lee1, 2, N. Li4, 1, 2, J. Oh1, 2, E. Kim1, 2, S. Kim3,
S. Lee4, 1, 2, D. Lee4, 1, 2, S. Cho4, 2, J. Chung4, 1, 2
1
Dermatology, Seoul National University Hospital, Jongno-gu, Seoul,
Korea (the Republic of), 2Institute of human-environmental interface
biology, Seoul, Korea (the Republic of), 3Physiology, Seoul National
University College of Medicine, Seoul, Korea (the Republic of),4
Dermatology, Seoul National University College of Medicine, Seoul,
Korea (the Republic of)Continued on next page.

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Concurrent Mini-Symposium 16 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM D: OHGI, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
15:05-15:15

ORAL 0262 [POSTER 1050]

Neutrophil-intrinsic NLRP12 and caspase-8 signal for inflammasomemediated host defense against staphylococcus aureus skin infections
M. P. Alphonse1, H. Liu1, D. Dikeman1, R. V. Ortines1, Y. Wang1,
Q. Liu1, C. Youn1, G. Wang1, E. A. Cahill1, D. Prifti1, A. Cox2, L. A. Garza1,
L. Miller1, 3, N. Archer1
1
Dermatology, Johns Hopkins Medicine, Baltimore, Maryland, UnitedStates, 2Molecular Microbiology and Immunology, Johns Hopkins
Medicine, Baltimore, Maryland, United States, 3Janssen Research andDevelopment LLC, Spring House, Pennsylvania, United States

15:15-15:25

ORAL 0263 [POSTER 959]

Identification of novel innate immune cells in human epidermis
T. Sato, Y. Ogawa, S. Shimada, T. Kawamura
Department of Dermatology, Yamanashi Daigaku Igakubu Daigakuin
Sogo Kenkyubu Igakuiki, Chuo, Yamanashi, Japan

15:25-15:35

ORAL 0264 [POSTER 1006]

Single-cell and spatial architecture of human tissue granulomas
reveals an aberrant immune-regulatory program underlying
sarcoidosis
A. Redl1, 2, T. Krausgruber2, D. Barreca2, C. Lim3, K. Doberer4,
L. Unterluggauer1, L. Kleissl5, C. Mayerhofer1, A. Kopf5, T. Weichhart3,
C. Bock2, G. Stary1
1
Department of Dermatology, Medizinische Universitat Wien, Wien,
Austria, 2Research Center for Molecular Medicine of the Austrian
Academy of Sciences, Vienna, Wien, Austria, 3Institute of Medical
Genetics, Medizinische Universitat Wien, Wien, Austria, 4Departmentof Nephrology, Medizinische Universitat Wien, Wien, Austria, 5Ludwig
Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria

15:35-15:45

ORAL 0265 [POSTER 1048]

NK cell populations are major contributors to pathogenesis in
hidradenitis suppurativa (HS)C. Raman1, M. Kashyap1, B. Mishra2, J. Deshane3, S. Mukhtar2,
C. A. Elmets1, M. Athar1
1
Department of Dermatology, University of Alabama at Birmingham,
Birmingham, Alabama, United States, 2Biological Sciences, Universityof Alabama at Birmingham, Birmingham, Alabama, United States,
3
Department of Medicine, University of Alabama at Birmingham,
Birmingham, Alabama, United States

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Concurrent Mini-Symposium 17

Pigmentation and Melanoma

Studies on all aspects of cutaneous and extracutaneous pigmentation; molecular cellular and biological facets of melanoma––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Nikolas Haase, Dr. Niroshana Anadasabapathy, Dr. Katia Boniface

13:15-13:25

ORAL 0266 [POSTER 1224]

AhR regulates the efferocytosis and polarization of tumor-associatedmacrophages through ALKAL1-mediated MerTK activation andpromotes melanoma progression
N. Wu, J. Tao
Doctor, Huazhong University of Science and Technology, Wuhan, Hubei,
China

13:55-14:05

14:05-14:15
13:25-13:35

ORAL 0267 [POSTER 1278]

Blocking tumor-intrinsic caspase-1 inflammasome sensitizes
melanoma response to anti-PD1 therapy by rejuvenating
dysfunctional CD8 T cells
P. K. Vaddi1, D. Osborne1, D. Ravindran-Menon1, T. Yamauchi1,
Z. Zhai1, M. Fujita1,2, 3
1
Dermatology, University of Colorado Anschutz Medical Campus, Aurora,
Colorado, United States, 2Department of Veterans Affairs Medical
Center, VA Eastern Colorado Health Care System, Aurora, Colorado,United States, 3Department of Immunology & Microbiology, Universityof Colorado Anschutz Medical Campus, Aurora, Colorado, United States

13:35-13:45

ORAL 0270 [POSTER 1282]

Basal cell carcinoma pigmentation is associated with melanocyte
proliferation and expression of the melanocyte mitogens endothelin
1 and 2 by tumor cells
E. A. Pedersen1, M. A. Grachtchouk1, M. E. Verhaegen1, L. Syu1,
P. W. Harms1, M. Gharaee-Kermani1, F. Ma1, J. Gudjonsson1, M. Ito2,
A. Dlugosz1
1
University of Michigan, Ann Arbor, Michigan, United States, 2NYU
Langone Health, New York, New York, United States

ORAL 0271 [POSTER 1240]

Distinct cAMP signaling microdomains differentially regulatemelanosomal pH and pigmentation
D. Zhou1, M. Yusupova1, J. You1, J. Gonzalez-Guzman2, M. Ghanta2,
H. Pu4, Z. Abdel-Malek3, J. D’Orazio4, S. Ito5, K. Wakamatsu5,
M. Harris2, J. Zippin1, 6, 7
1
Dermatology, Weill Cornell Medicine, New York, New York, UnitedStates, 2The University of Alabama at Birmingham Department of Cell
Developmental and Integrative Biology, Birmingham, Alabama, UnitedStates, 3Dermatology, University of Cincinnati, Cincinnati, Ohio, UnitedStates, 4Pediatrics, University of Kentucky, Lexington, Kentucky, UnitedStates, 5Institute for Melanin Chemistry, Fujita Ika Daigaku, Toyoake,
Aichi, Japan, 6Pharmacology, Weill Cornell Medicine, New York, New
York, United States, 7Englander Institute of Precision Medicine, Weill
Cornell Medicine, New York, New York, United States

ORAL 0268 [POSTER 1216]

SIRT7 orchestrates melanoma progression by simultaneously
promoting cell survival and immune evasion via UPR activation
X. Yi, W. Guo, H. Wang, Y. Yang, C. Li
Air Force Medical University, Xi’an, Shaanxi, China

13:45-13:55

ORAL 0269 [POSTER 1191]

Immunotherapy with 4-1BBL-expressing iPSC-derived proliferating
myeloid cells amplifies antigen-specific T cell infiltration in advanced
melanoma
H. Kuriyama1, T. Kimura1, H. Kanemaru1, A. Miyashita1, T. Inozume2, R.
Zhang3, Y. Uemura3, S. Fukushima1
1
Department of Dermatology and Plastic Surgery, Faculty of Life
Sciences, Kumamoto University, Kumamoto, Kumamoto, Japan,
2
Department of Dermatology, Chiba University, Chiba, Japan, 3Division ofCancer Immunotherapy, Exploratory Oncology Research & Clinical Trial
Center, National Cancer Center, Chiba, Japan

14:15-14:25

ORAL 0272 [POSTER 1274]

Targeting tumour vascularisation through endothelial-specific Sox9
deletion reduces melanoma metastasis
G. Hashemi, L. Sormani Le Bourhis, J. Dight, C. Zhou, E. Roy,K. Khosrotehrani
The University of Queensland, Saint Lucia, Queensland, Australia

14:25-14:35

ORAL 0273 [POSTER 1189]

PD-1 blockade may promote not only the reactivation of preexistingtumor-specific T cell clones but also the infiltration of new clones
T. Inozume1, 4, 3, J. Nagasaki2, 4, M. Kawazu4, T. Kawamura3,
K. Yamashita5, Y. Togashi2, 41
Dermatology, Chiba University, Chiba, Japan, 2Tumor Microenvironment,
Okayama University, Okayama, Japan, 3Dermatology, University of
Yamanashi, Kofu, Japan, 4Research Institute, Chiba Cancer Center,
Chiba, Japan, 5KOTAI Biotechnologies Inc, Osaka, Japan

Continued on next page.

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Concurrent Mini-Symposium 17 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM E: MOONLIGHT, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:35-14:45

ORAL 0274 [POSTER 1204]

Immunogenic cell death by inhibition of glucose-6-phosphate
dehydrogenase enhances the efficacy of immunotherapy in malignant
melanoma
M. Nakamura, M. Yoshimitsu, T. Magara, S. Kano, H. Kato, A. Morita
Department of Geriatric and Environmental Dermatology, Nagoya
Shiritsu Daigaku Daigakuin Igaku Kenkyuka Igakubu, Nagoya, Aichi,
Japan

14:45-14:55

ORAL 0276 [POSTER 1262]

Immuno-apoptotic priming to enhance the efficacy of
immunotherapies in melanoma
N. Mukherjee, R. Tobin, E. Katsnelson, M. McCarter, D. Norris,
Y. Shellman
University of Colorado, Denver, Colorado, United States

15:05-15:15

ORAL 0279 [POSTER 1214]

Targeting SHOC2 disrupts MEK/ERK signaling and inhibits viability of
NRAS-mutant human melanoma cells.
R. A. Francois1, L. Young2, F. McCormick2
1
Departments of Dermatology and Pathology, University of California
San Francisco, San Francisco, California, United States, 2Helen Diller
Family Comprehensive Cancer Center and Department of Cellular andMolecular Pharmacology, University of California San Francisco, San
Francisco, California, United States

ORAL 0275 [POSTER 1220]

Cytosolic acetyl-CoA drives tumor immune evasion via the epigenetic
regulation of PD-L1 in melanoma
H. Wang, W. Guo, X. Yi, Y. Yang, C. Li
Xijing Hospital, Xian, Shaanxi, China

14:55-15:05

15:25-15:35

15:35-15:45

ORAL 0280 [POSTER 1181]

Delivery of costimulatory molecules and immunostimulatory
cytokines leads to targeted and systemic immune activation against
melanoma in vivo
K. M. Luly1, J. J. Green1, J. C. Sunshine2, 1, S. Y. Tzeng1
1
Biomedical Engineering, Johns Hopkins University School of Medicine,
Baltimore, Maryland, United States, 2Dermatology, Johns Hopkins
University School of Medicine, Baltimore, Maryland, United States

ORAL 0277 [POSTER 1261]

ER stress facilitates anti-cancer immunosurveillance and improves
immunotherapy efficacy in melanoma
Y. Yang, S. Guo, H. Wang, C. Li, X. Yi, W. Guo
Department of Dermatology, Xijing Hospital, Fourth Military Medical
University, Xi’an, Shaanxi, China

15:15-15:25

ORAL 0278 [POSTER 1275]

A mutual repression between MITF and neural transcription factors
specifies the fate of schwann cell precursors
A. Kawakami1, M. Hejna2, M. Hoang3, K. Kabashima1, J. Song2,
D. E. Fisher4
1
Department of Dermatology, Kyoto University Graduate School of
Medicine, Kyoto, Japan, 2Department of Physics, University of Illinois,
Urbana, Illinois, United States, 3Department of Pathology, Massachusetts
General Hospital, Harvard Medical School, Boston, Massachusetts,
United States, 4Cutaneous Biology Research Center, Department of
Dermatology, Massachusetts General Hospital, Harvard Medical School,
Charlestown, Massachusetts, United States

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Concurrent Mini-Symposium 18

Late-Breaking Abstracts

Abstracts from all categories (as submitted during the Late-Breaking Submission period)––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
Moderators:
Dr. Manabu Ohyama, Dr. Wendy Weinberg, Dr. Sabine Eming
13:15 -13:25

ORAL 0281 (POSTER LB 1658)

Eco-evolutionary profiling of the earliest steps in the skincarcinogenesis
S. Avdieiev1, 3, L. Tordesillas2, K. M. Prieto-Sarmiento2, O. Chavez
Chiang2, Z. Chen4, L. Silva Simoes1, Y. Chen4, N. Andor1, C. Whelan1, 3,
R. Gatenby1, 3, E. Flores5, 3, J. Brown1, 3, K. Tsai2, 3
1Integrated Mathematical Biology, Moffitt Cancer Center, Tampa, Florida,
United States, 2Tumor Biology, Moffitt Cancer Center, Tampa, Florida,
United States, 3Cancer Biology and Evolution Program, Moffitt Cancer
Center, Tampa, Florida, United States, 4Biostatistics and Bioinformatics,
Moffitt Cancer Center, Tampa, Florida, United States, 5Molecular
Oncology, Moffitt Cancer Center, Tampa, Florida, United States

13:55 – 14:05

14:05 – 14:15

ORAL 0282 (POSTER LB 1763)

Combinatorial BRD9 and SMO targeting synergistically suppress UVinduced BCC tumor burden in a murine model of Gorlin syndrome(GS)
A. Kim, Y. Zhu, D. Chen, M. Elmais, M. Athar, D. R. Bickers
Columbia University Irving Medical Center, New York, New York, UnitedStatesORAL 0283 (POSTER LB 1645)

IL-9 sensitizes human pathogenic Th2 cells to pro-inflammatory
IL-18 signals in atopic dermatitis
S. Schärli1, F. Luther1, O. Steck1, J. Thyssen2, N. Bertschi1,
C. Schlapbach1
1
Department of Dermatology, Inselspital Universitatsspital Bern,
Bern, Bern, Switzerland, 2Department of Dermatology and Allergology,
Gentofte Hospital, Hellerup, Hovedstaden, Denmark

ORAL 0284 (POSTER LB 1751)

Downstream effects of IL-13Rα1 blockade on type 2 inflammation
and Th1 immune axis activation in atopic dermatitis
S. V. Reddy1, Z. A. Bordeaux1, A. Rajeh2, D. M. Sivaloganathan2,
H. Cornman2, A. Kambala2, J. Adams1, F. Cevikbas3, S. Kwatra2,
M. Kwatra1
1
Anesthesiology, Duke University School of Medicine, Durham, North
Carolina, United States, 2Dermatology, Johns Hopkins University
School of Medicine, Baltimore, Maryland, United States, 3ASLAN
Pharmaceuticals Pte Ltd, San Mateo, California, United States

ORAL 0288 (POSTER LB 1734)

GPNMB supresses the antimicrobial activity of macrophages throughtargeting VAMP8
Z. Yan1, N. Dang1, H. Liu2, F. Zhang2
1
Department of Dermatology, Shandong Provincial Hospital, Jinan,
Shandong, China, 2Shandong First Medical University, Jinan, Shandong,
China

14:35 – 14:45
13:45 – 13:55

ORAL 0287 (POSTER LB 1640)

Dynamic profiling of desmoglein 3-reactive T helper cells in
pemphigus vulgaris
K. Volkmann1, 2, J. Hinterseher1, A. Polakova1, D. Didona1, M. Hertl1
1
Department of Dermatology and Allergology, Philipps-Universitat
Marburg, Marburg, Hessen, Germany, 2Bundesinstitut fur Arzneimittel
und Medizinprodukte, Bonn, Nordrhein-Westfalen, Germany

14:25 – 14:35
13:35 -13:45

ORAL 0286 (POSTER LB 1754)

Treatment of human palmoplantar keratoderma skin equivalents witha TRPV3 antagonist, KM-001
M. Caley1, M. Idrissi1, L. Braiman2, E. Brener2, E. O'Toole1
1Centre for Cell Biology and Cutaneous Research, Queen Mary Universityof London, London, United Kingdom, 2Kamari Pharma, Ness Ziona, Israel

14:15 – 14:25
13:25 -13:35

ORAL 0285 (POSTER LB 1672)

Senescent Melanocytes in Nevus Skin Stimulate Hair Growth
X. Wang1, R. Ramos1, N. Shettigar1, Q. Nie2, M. Plikus1
1
Developmental and Cell Biology, University of California Irvine, Irvine,
California, United States, 2Mathematics, University of California Irvine,
Irvine, California, United States

ORAL 0289 (POSTER LB 1756)

The Role of cNOS in UV-induced DNA Damage and Repair
S. Wu1, 4, V. Bahamondes Lorca1, 2, L. Tong1, 3
1
Edison Biotechnology Institute, Ohio University, Athens, Ohio, UnitedStates, 2Tecnología Médica, Universidad de Chile, Santiago de Chile,
Chile, 3Nationwide Children's Hospital, Columbus, Ohio, United States,
4Chemsitry and Biochemistry, Ohio University, Athens, Ohio, UnitedStates

14.45 – 14.55

ORAL 0290 (POSTER LB 1654)

Mitochondrial transfer from cancer cells induces pro-tumorigenic
features in skin fibroblasts
M. Cangkrama, H. Liu, J. Whipman, C. Gaebelein, J. Vorholt, S. Werner
Eidgenossische Technische Hochschule Zurich, Zurich, Zürich,
Switzerland

Continued on next page.

132

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

Concurrent Mini-Symposium 18 - Continued––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
13:15 – 15:45
ROOM F: HARMONY, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––
14:55 – 15:05

ORAL 0291 (POSTER LB 1671)

Large-scale skin scRNA-seq profiling highlights distinct Body
Site-specific ligand-receptor interactions and pathways inkeratinocytes
R. Wasikowski1, M. T. Patrick1, Q. Li1, Q. Nie2, B. Andersen3, M. Plikus2,
J. M. Kahlenberg4, A. Billi1, L. Tsoi1, J. Gudjonsson1
1
Dermatology, University of Michigan, Ann Arbor, Michigan, UnitedStates, 2Developmental and Cell Biology, University of California Irvine,
Irvine, California, United States, 3Medicine, University of California Irvine,
Irvine, California, United States, 4Rheumatology, University of Michigan,
Ann Arbor, Michigan, United States

15:05 – 15:15

15:35 – 15:45

ORAL 0295 (POSTER LB 1778)

Wound Closure in diabetic db/db mice is facilitated by autologous
hair-follicle associated pluripotent (HAP)stem cells
A. Hasegawa1, 2, K. Obara2, N. Takaoka1, K. Shirai2, Y. Hamada2,
N. Arakawa2, R. Aki2, R. Hoffman3, 4, Y. Amoh21dermatology, Kitasato University Graduate School of Medical Science,
Sagamihara, Kanagawa, Japan, 2dermatology, Kitasato Daigaku Igakubu,
Sagamihara, Kanagawa, Japan, 3Anti Cancer Inc, San Diego, California,
United States, 4Surgery, University of California San Diego, La Jolla,
California, United States

ORAL 0292 (POSTER LB 1722)

Ablating ATP2C1 in human keratinocytes impairs intercellularadhesion, disrupts epidermal integrity, and reveals therapeutictargets for Hailey-Hailey disease
J. L. Ayers1, A. Tiwaa1, M. K. Sarkar2, J. Gudjonsson2, C. L. Simpson1
1
Dermatology, University of Washington, Seattle, Washington, UnitedStates, 2Dermatology, University of Michigan, Ann Arbor, Michigan,
United States

15:15 – 15:25

ORAL 0293 (POSTER LB 1735)

Utilizing Large-scale Sequencing to Depict Changes in Immune Cells
during Cancer Immunoediting in Epidermal Neoplasms
X. Fan, D. R. Roop
Dermatology, University of Colorado Anschutz Medical Campus Schoolof Medicine, Aurora, Colorado, United States

15:25 – 15.35

ORAL 0294 (POSTER LB 1792)

CCL2 restores adult cells to regenerate hair follicles by
microenvironmental regulation
W. Wu1, 2, W. Zhou3, J. Jiang1, M. Wang1, J. Zhang1, X. Shen1, Q. Tang2,
H. Liu2, L. Yang1, M. Lei1
1
Bioengineering, Chongqing University, Chongqing, China, 2Chongqing
University Three Gorges Hospital, Chongqing, China, 3Chongqing
University Cancer Hospital, Chongqing, China

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

133

ISID 2023 Closing Ceremony––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
15:50 – 16:00
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––HOSTED BY:
Prof. Kenji Kabashima, JSID President and Prof. Dong-Youn Lee, KSID President

AGENDA:• Post-Meeting Presidential Remarks- International Societies for Investigative Dermatology (ISID),
Dr. Russell Hall
- Australasian Society for Dermatology Research (ASDR),
Prof. Johannes Kern
- European Society for Dermatological Research (ESDR),
Prof. Sabine Eming- Taiwanese Society for Investigative Dermatology (TSID),
Prof. Sung-Jan Lin- Society for Investigative Dermatology (SID),
Dr. Lynn Cornelius• A message about ISID 2028 from ESDR President, Prof. Sabine Eming• Conclusion

134

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGAsia-Oceania Symposium––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––SATURDAY, MAY 13, 2023
16:05 – 18:05
ROOM A: CONCORD BALLROOM, KEIO PLAZA HOTEL––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––––AGENDA:
16:05

COVID-19 vaccines related cutaneous reactions
Presented by: Chun-Bing Chen (Chinese Taipei)
Chair: Riichiro Abe (Japan)

16:21

Altering cell mechanics to inhibit melanoma cell migration, invasion and metastasis
Presented by: Nikolas Haass (Australia)		
Chair: Chia-Yu Chu (Chinese Taipei)

16:37

Unravelling the NLRP1 inflammasome through the study of Genodermatoses
Presented by: Kenneth Lay (Singapore)			
Chair: John Common (Singapore)

16:53

Role of ATP-P2X7 axis in Melanogenesis
Presented by: Sang-Ho Oh (Korea)			
Chair: Weon Ju Lee (Korea)

17:09

Bosentan versus nifedipine in the treatment of vasculopathy in systemic Sclerosis: A
randomized clinical trial
Presented by: Trinh Ngoc Phat (Vietnam)			
Chair: Qianjin Lu (China)

17:25

SJS/TEN; Thailand perspective
Presented by: Pawinee Rerknimitr (Thailand)			
Chair: Victoria Mar (Australia)

17:41

Neuron-immunopathology in Psoriasis
Presented by: Honglin Wang (China)
Chair: TBD		

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETING

135

NOTES

www.isiderm.org
136

1ST INTERNATIONAL SOCIETIES FOR INVESTIGATIVE DERMATOLOGY MEETINGMISCELLANEOUS

KSID

ESDR

49th JSID
The 49th Annual Meeting of the Japanese Society for Investigative Dermatology

What We Have Learned andWhere We Are Going!

December 6(Fri.) - 8(Sun.) 2024
President Akimichi Morita, M.D., Ph.D.
Dates

Department of Geriatric and Environmental Dermatology,
Nagoya City University Graduate School of Medical Siences

Nagoya City University Graduate School of Medical Siences

1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan

https://jsid49.jp/

WINC AICHI

Aichi Industry & Labor Center

4-4-38 Meieki, Nakamura-ku, Nagoya, Aichi 450-0002, Japan

Secretariat : Department of Geriatric and Environmental Dermatology,

U R L:

Venue

E-mail :Meeting Organizer : The Japanese Dermatological Association
1- 4, Hongo 4-chome, Bunkyo-ku, Tokyo 113-0033, JapanFax : +81-3-3812-6790

jsid49@dermatol.or.jp

THE OBJECTIVES AND AIMS OF
THE ASSOCIATION ARE:
• To promote scientific research in dermatology, skin biology andallied subjects through the study of individual humans, animals,
and model systems.
• To provide a forum for interaction and information exchange
between doctors treating patients with disorders of the skin andscientists working in the field of cutaneous research.
• To enhance the treatment of people with disorders of the skinthrough making available the latest advances in research anddiagnostic techniques.
• To investigate possible sources of funding for skin research.
• To establish links with the International Skin Research Societies,
in particular the American Society of Investigative Dermatology,
the Japanese Society of Investigative Dermatology, the British
Society of Investigative Dermatology and the European Societyof Dermatology Research. In addition to establishing formal links
with these societies, The Australasian Society of Dermatology
Research would aim to participate in joint meetings.

LOCATION					CONTACT

9/397 Smith St.					asdr@asnevents.net.au
Fitzroy, VIC, 3065

Making a difference forpsoriasis patients
We have a fundamental commitment to improving the lives of thoseliving with psoriasis. We maintain deep connections with patient andscientific communities to drive innovation and co-create life-changing
solutions. We challenge accepted beliefs and boundaries to makea meaningful difference to people’s health.

© UCB Biopharma SRL, 2023. All rights reserved.GL-P-DA-PSO-2300034. Date of preparation: February 2023.

Thank you for coming?