PROGRAM
January 20 (Thu.)
Opening Ceremony

17:00-17:30
Chairpersons: Etsuo Niki, Matthew B. GrishamSpecial Lecture 1

17:30-18:10
Chairperson: Helmut Sies

SL1Free Radical-Mediated Lipid Peroxidation; Contribution to Medicine
Toshikazu Yoshikawa
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., Japan

Special Lecture 2

18:10-18:50
Chairperson: Toshikazu Yoshikawa

SL2

The RCAN1 Gene May Link Oxidative Stress with Alzheimer Disease, Down Syndrome, andHuntington Disease
Kelvin J. A. Davies
Ethel Percy Andrus Gerontology Cent. of the Davis Sch. of Gerontology; and Div. of Molecular& Computational Biology, Dept. of Biological Sci. of the Coll. of Letters, Arts & Sci., the Univ.
of Southern California, USA

Welcome Reception

19:00-20:30－4－

January 21 (Fri.)
Session 1

8:30-10:00
Chairpersons: Toshihiko Ozawa, Michael J. Davies

1

In vivo Free Radical Imaging using New Modality, OMRI
Hideo Utsumi
Innovation Center for Med. Redox Navigation Kyushu Univ., Japan2

Mitochondrial Oxidative Stress in Cardiac Remodeling and Failure
Hiroyuki Tsutsui
Dept. of Cardiovascular Med., Hokkaido Univ. Grad. Sch. of Med., Japan3

Mitochondrial Function in a Neurodegenerative Model
Harsh Sancheti, Fei Yin, Enrique Cadenas
Pharmacology & Pharmaceutical Sci., Sch. of Pharmacy, Univ. of Southern California, USA

Coffee Break

10:00-10:30

Session 2

10:30-12:00
Chairpersons: Yuji Naito, Young-Joon Surh

4

Carbon Monoxide (CO)-Dependent Modulation of Inflammatory Response in Polymorphonuclear
Leukocytes and Vascular Endothelial Cells in Experimental Model of Sepsis
Gediminas Cepinskas1, Shinjiro Mizuguchi1,2Centre for Critical Illness Research, Lawson Health Research Inst., 2Dept. of Thoracic Surgery,
Osaka City Univ. Hosp., Japan
1

5

Vascular Protection by Heme Oxygenase-1
Roland Stocker
Sch. of Medical Sci. (Pathology) and Bosch Inst., The Univ. of Sydney, Australia

6

CO-mediated Regulation of Remethylation and Transsulfuration Pathways: The Impact throughGlobal Macromolecular Methylation and H2S
Makoto Suematsu1, Takehiro Yamamoto2, Naoharu Takano2, Mayumi Kajimura1
Dept. of Biochemistry & JST ERATO Suematsu Gas Biology Project, 2Sch. of Med., Keio Univ.,
Japan

1

Lunch

12:00-13:00－5－

Session 3

13:00-14:30
Chairpersons: Kazunori Anzai, Matthew B. Grisham

7

Myeloperoxidase-catalysed Oxidation: Mechanisms of Biological Damage and its Prevention
Michael J. Davies
The Heart Research Inst., Univ. of Sydney, Australia

8

Control of Adrenal Steroidogenesis via H2O2-Dependent, Reversible Inactivation of Peroxiredoxin
III in Mitochondriae
Sue Goo Rhee, In Sup Kil
Div. of Life and Pharmaceutical Sci., Ewha Woman’s Univ., Korea

9

Mechanisms of Neuronal Cell Death Induced by 24(S)-Hydroxycholesterol
Noriko Noguchi, Kazunori Yamanaka, Yoshiro Saito, Yasuomi Urano
Dept. of Medical Life Systems, Doshisha Univ., Japan

Coffee Break

14:30-15:00

Session 4

15:00-16:30
Chairpersons: Junichi Fujii, Kelvin J. A. Davies

10

Regeneration of Infarcted Myocardium with Resveratrol-Modified Cardiac Stem Cells-Role ofMicro RNA
Dipak K. Das
Harvard Uiv. Medeical Center, USA

11

Redox Signaling Modulated by Electrophilic Cyclopentenone Prostaglandins
Young-Joon SurhWCU Dept. of Biopharmaceutical Sci. and Molecular Med. and Nat’l Research Laboratory of
Molecular Carcinogenesis and Chemoprevention, Coll., of Pharmacy, Seoul Nat’l Univ., Korea

12

Cell Signaling Mediated by Nitrated Cyclic Guanine Nucleotide
Takaaki Akaike
Dept. of Microbiology, Graduate Sch. of Medical Sci., Kumamoto Univ., Japan

Photo with Prof. Toshikazu Yoshikawa

16:30-17:00

Poster discussion

17:00-19:00

Banquet19:00-21:00－6－

January 22 (Sat.)
Session 5

8:30-10:00
Chairpersons: Keiichiro Suzuki, Enrique Cadenas

13

Multitargets of Dietary Flavonoids in Modulation of Oxidative StressJunji Terao
Dept. of Food Sci., Grad. Sch. of Nutr. and Bioscience, the Univ. of Tokushima, Japan

14

Glyco-redox Research: A Link between Redox Research and Glycobiology
Ken Shirato1, Kazuki Nakajima1, Hiroaki Korekane1, Shinji Takamatsu1, Takashi Angata2,
Kazuaki Ohtsubo1, Naoyuki Taniguchi1,3.
Inst. for Scientific and Industrial Research Osaka Univ., 2Osaka Univ. Grad. Sch. of Med., 3RIKEN
Advanced Sci. Inst., Systems Glycobiology Group, Japan1

15

Flavanols, Vascular Nitric Oxide, and Hypertension
Cesar G. Fraga
Physical Chemistry-PRALIB, Sch. of Pharmacy and Biochemistry, Univ. of Buenos AiresCONICET, Argentina, Dept. of Nutr., Univ. of California, Davis, USA

Coffee Break

10:00-10:30

Session 6

10:30-12:00
Chairpersons: Shigeru Okada, Gediminas Cepinskas

16

Chemical and Immunochemical Detection of Oxidative Stress Biomarkers at Early Stage
Inflammation
Toshihiko Osawa
Dept. of Health and Nutr., Faculty of Psycological & Physical Sci., Aichi Gakuin Univ., Japan

17

Divergent Roles of Superoxide and Nitric Oxide in Liver Ischemia and Reperfusion Injury
Matthew B. Grisham
Immunology Research Group, LSU Health Sci. Center, USA

18

Oxidative Stress Markers and a Free Radical Scavenger Drug, Edaravone
Yorihiro Yamamoto
Sch. of Bioscience and Biotechnology, Tokyo Univ. of Tec., Japan

Lunch

12:00-13:00－7－

Session 7

13:00-14:30
Chairpersons: Patricia Oteiza, Yuichiro J. Suzuki

19

Cholesterol Oxidation Products in the Pathogenesis of Human Major Chronic Diseases
Gabriella Leonarduzzi, Fiorella Biasi, Paola Gamba, Simona Gargiulo, Cinzia Mascia,
Gabriella Testa, Marco Maina, Giuseppe Poli
Dept. of Clinical and Biological Sci., Univ. of Turin, Italy

20

Clinical and Experimental Evidence for Oxidative Stress as an Exacerbating Factor of Diabetes
Mellitus
Ryoichi Takayanagi1, Toyoshi Inoguchi1,2, Keizo Ohnaka3
Dept. of Internal Med. and Bioregulatory Sci., Grad. Sch. of Medical Sci., Kyushu Univ., Japan,
Innovation Center for Medical Redox Navigation, Kyushu Univ., Japan, 3Dept. of Geriatric Med.,
Grad. Sch. of Medical Sci., Kyushu Univ., Japan
1

2

21

Role of Iron in Carcinogenesis
Shinya Toyokuni
Dept. of Pathology and Biological Responses, Nagoya Univ. Grad. Sch. of Med., Japan

Session 8

14:30-16:00
Chairpersons: Etsuo Niki, Giuseppe Poli

22

Oxidative Fate of Mitochondrial Fat in Cell Death
Valerian E. Kagan
Center for Free Radical and Antioxidant Health, Dept. of Environmental Health, Univ. of Pittsburgh,
USA

23

High Selenium Intake and Increased Diabetes Risk: Experimental Evidence for Interplay
between Selenium and Carbohydrate Metabolism
Holger Steinbrenner, Bodo Speckmann, Antonio Pinto, Helmut Sies
Inst. for Biochemistry and Molecular Biology I, Heinrich Heine Univ., Germany

24

Whether, When and How Vitamin E can Protect against Pathogenic Oxygen-Originated Free
Radicals
Angelo Azzi
Vascular Biology Laboratory, JM USDA-HNRCA at Tufts Univ., USA

Closing Remarks

16:00-16:15
Chairperson: Matthew B. Grisham－8－

Poster Session
P01

17:00-19:00, Jan. 21

Dual regulation of hepatocyte apoptosis by reactive oxygen species: increases in transcriptional
expression and decreases in proteasomal degradation of BimEL
Yasuhiro Ishihara1, Kenji Takeuchi2, Fumiaki Ito2, Norio Shimamoto1
Lab. of Pharmacol., Fac. of Pharm. Sci. Kagawa, Tokushima Bunri Univ., 2Dept. of Biochem.,
Fac. of Pharm. Sci., Setsunan Univ., Japan1

P02

SOD1 deficiency induces the cellular senescence in mouse embryonic fibroblast even at low
oxygen condition.
Satoshi Tsunoda, Noriko Kibe, Toshihiro Kurahashi, Junichi Fujii
Dept. of Biochem. and Mol. Biol., Grad. Sch. of Med. Sci., Yamagata Univ., Japan

P03

Changes in renal iron metabolism by SOD1 deficiency
Daisaku Yoshihara, Noriko Fujiwara, Haruhiko Sakiyama, Hironobu Eguchi, Keiichiro Suzuki
Dept. of Biochem., Hyogo Coll. Med., Japan

P04

Activation of Bax gene and caspase 3 in hydrogen peroxide-induced premature senescence ofhuman diploid fibroblasts and its modulation by gamma-tocotrienol
Suzana Makpol1, Norhazira Abdul Rahim1, Kien Hui Chua2, Wan Zurinah Wan Ngah1
Dept. of Biochem., Fac. of Med., Nat'l Univ. of Malaysia, 2Dept. of Physiology, Fac. of Med.,
Nat'l Univ. of Malaysia, Malaysia
1

P05

Peroxiredoxin 4 is a multifunctional redox protein working in endoplasmic reticulum andcytoplasm
Junichi Fujii1, Yoshihito Iuchi1, Xuhong Zhang1, Satoshi Tsunoda1, Yoshitaka Ikeda2
Dept. of Biochem. & Mol. Biol., Grad. Sch. of Med. Sci., Yamagata Univ., 2Div. of Mol. Cell
Biol., Dept. of Biomol. Sci., Saga Univ. Fac. of Med., Japan
1

P06

Oxidative stress and matrix metalloproteinase activity in preeclampsia
Rashmi Mukherjee1, Koel Chaudhury1, Chaitali D Ray2, Swagata Dasgupta3
Sch. of Med. Sci. and Tec., Indian Inst. of Tec., 2Dept. of Obstetrics and Gynecology, Inst. of Post
Grad. Med. Education and Research, 3Dept. of Chemistry, Indian Inst. of Tec., India

1

P07

Metabolomic analysis of uremic solute and it toxic potential
Takaaki Abe1, Tomoyoshi Soga2
Tohoku Univ. Grad. Sch. of Med., 2Keio Univ., Japan1

P08

Heme carrier protein 1 involves a cancer specific porphyrin accumulation
Hirofumi Matsui, Kazuhiro Hiyama, Tsuyoshi Kaneko, Yumiko N Nagano, Ichinosuke Hyodo
Div. of Gastroenterology, Grad. Sch. of Comprehesive Human Sci., Univ. of Tsukuba, Japan

－9－

P09

Reaction of melatonin with free radicals in a protic medium and the mechanism
Ikuo Nakanishi1, Kabir Zoardar2, Masato Kamibayashi1, Kei Ohkubo3, Tomonori Kawashima1,
Ken-ichiro Matsumoto1, Shunichi Fukuzumi3, Toshihiko Ozawa4, Kazunori Anzai5
Research Center for Charged Particle Therapy, Nat'l Inst. of Radiological Sci., Japan, 2Bangladesh
Atomic Energy Commission, Bangladesh, 3Dept. of Material and Life Sci., Grad. Sch. ofEngineering, Osaka Univ., 4Dept. of Health Pharmacy, Yokohama Coll. of Pharmacy Nihon
Pharmaceutical Univ., Japan
1

P10

Novel mechanism of ROS signaling: Protein carbonylation
Yuichiro J. Suzuki
Dept. of Pharmacology, Georgetown Univ. Med. Center, USA

P11

Determination of reactive oxygen species associated with the degeneration of dopaminergic
neurons during dopamine metabolism
Mayumi Yamato1, Wataru Kudo2, Takeshi Shiba2, Ken-ichi Yamada2, Toshiaki Watanabe2,
Hideo Utsumi2
Med. Redox Navi., Kyushu Univ., 2Fac. of Pharm Sci., Kyushu Univ., Japan

1

P12

Nitration of tryptophan residues is a novel post-translational modification occurring in naiveand differentiated PC12 cells.
Fumiyuki Yamakura1, Hiroaki Kawasaki2, Ayako Shigenaga3, Takeshi Baba4, Munehiro Uda4,
Hideoki Ogawa4, Kenji Takamori4Sch. of Health Care and Nurs. Juntendo Univ., 2Inst. for Environ. and Gende-spec. Med. Juntendo
Univ., 3Sch. of Health and Sports Sci. Juntendo Univ., 4Sch. of Med. Juntendo Univ.
1

P13

Oxidative formation of 8-hydroxy-2’-deoxyguanosine in DNA is mediated by aliphatic peroxides
but not by hydrogen peroxide
Yoriko Ishigaki, Keisuke Ueda, Hashimoto Takashi, Kazuki Kanazawa
Kobe Univ., Japan

P14

Posttranslational modification of peroxiredoxin 6 by methylglyoxal in diabetic acetic acid-induced
gastric ulcer
Tomoko Oya-Ito1, Yuji Naito1, Tomohisa Takagi1, Hitomi Okada1, Keisuke Shima2, Toshikazu
Yoshikawa1
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med. Grad. Sch. of Med. Sci.,
Shimadzu Corp., Japan

1
2

P15

Analysis of acrolein modified proteins associated with the etiology of delayed gastric ulcer healingin mice with diabetes
Ryusuke Horie1, Yuji Naito1, Tomohisa Takagi1, Tomoko Oya-Ito1, Hitomi Okada1, Kazuhiko
Uchiyama1, Osamu Handa1, Hiroshi Ichikawa1, Koji Uchida2, Toshikazu Yoshikawa1
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., 2Nagoya Univ., Japan1－ 10 －

P16

Detection of Ne-(hexanoyl) lysine-modified tropomyosin 1 in RGK-1 cells
Kohei Fukumoto1, Yuji Naito1, Hitomi Okada1, Tomohisa Takagi1, Tomoko Oya-Ito1, Yumiko
Nagano2, Hirofumi Matsui2, Yoji Kato3, Toshihiko Osawa4, Toshikazu Yoshikawa1
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., 2Dept. of Gastroenterology,
Inst. of Clinical Med., Univ. of Tsukuba, 3Sch. of Human Sci. and Environment, Univ. of Hyogo,
4Dept. of Nutr. Sci., Aichi Gakuin Univ., Japan1

P17

In vivo evaluation of novel nitroxyl radicals with reduction stability
Ken-ichi Yamada1, Yuichi Kinoshita1, Toshihide Yamasaki1, Fumiya Mito1, Mayumi Yamato2,
Nuttabut Kosem2, Kiyoshi Sakai2, Hideo Utsumi1,2
1

P18

Fac. of Pharm. Sci., Kyushu Univ., 2Med. Redox Navi., Kyushu Univ., Japan

Tocotrienol rich fraction modulates cell cycle in cellular aging
Lina Wati Durani1, Musalmah Mazlan1, Chua K Hui2, Wan Zurinah Wan Ngah1, Suzana Makpol1
Dept. of Bioch., Fac. of Med., The Nat. Univ. of Malaysia, 2Dept. of Physiol., The Nat. Univ. of
Malaysia, Malaysia

1

P19

Influence of histidine on the wound restoration mechanism of the rat intestinal epithelial cells
Hiroshi Ichikawa1, Ayako Wakahara1, Tomohisa Takagi2, Satoko Adachi2, Madoka Yasui1, Chikako
Minami1, Kazuhiko Uchiyama2, Yuji Naito2, Yukiko Minamiyama3, Toshikazu Yoshikawa2
Grad. Sch. of Life and Med. Sci., Doshisha Univ., 2Molecular Gastroenterology and Hepatology,
Kyoto Pref. Univ. of Med., 3Grad. Sch. of Life and Environmental Sci., Kyoto Pref.Univ., Japan

1

P20

Increase in the cellular NAD+/NADH ratio by NQO1 activation prevents age-related hearing
loss in miceHong-Seob So, Raekil Park
Dept. of Microbio. Wonkwang Univ. Sch. of Med., Korea

P21

Nitric oxide (NO) signaling is involved in the maintenance of stemness and malignancies inglioma stem-like cells
Chang-Hwan Yoon1, Kyung-Hwan Hyun1, Rae-Kwon Kim1, Hyejin Lee1, Eun-Jung Lim1, Hee
Chung2, Min-Jung Kim1, Su-Jae Lee1
Dept. of Chemistry, Research Inst. for Natural Sci., Hanyang Univ., 2Dept. of Microbiology, Coll.
of Med., Hanyang Univ., Korea
1

P22

Ionizing radiation increased mitochondrial electron transport chain activity and mitochondrial
content in human lung carcinoma A549 cells
Tohru Yamamori1, Hironobu Yasui1, Hideo Nakamura2, Masayuki Yamazumi1, Osamu Inanami1
Lab. of Radiat. Biol., Grad. Sch. of Vet. Med. Sci., Hokkaido Univ., 2Dept. of Humanities andRegional Sci., Hokkaido Univ. of Edu., Japan

1－ 11 －

P23

pH dependent reaction of nitroxyl radicals and glutathione
Ken-ichiro Matsumoto1, Ikuo Nakanishi1, Murali Krishna2
1

P24

Nat'l Inst. of Radiological Sci., 2Nat'l Cancer Inst./Nat'l Inst. of Health, Japan

Reactive oxygen species-mediated Radiosensitizing effects of xanthohumol on MCF-7 and MCF7/ADR cells
Youra Kang1, Se-Woong Heo1, Sumin Park1, Keon Wook Kang2, Jung-Ae Kim1
Coll. of Pharmacy, Yeungnam Univ., 2Coll. of Pharmacy , Chosun Univ., Korea

1

P25

A synthetic polyphenol compound, 3-geranyl-2, 4, 6-trihydroxy-acetophenone, induces apoptosis
and chemosensitization of adriamycin-resistant MCF-7 breast cancer cells
Su-Young Park1, Mi-Yeon Cho1, Min-A Park1, Yu-Ra Kang1, Yong Rok Lee2, Keon Wook Kang3,
Jung-Ae Kim1
Coll. of Pharmacy, Yeungnam Univ., 2Sch. of Chemical Engineering and Tec., Yeungnam Univ.,
Coll. of Pharmacy, Chosun Univ., Korea

1
3

P26

Free radical scavenging activities of Salvia brachyantha and its protective effect against oxidative
cardiac cell injury
Mohammad Ali Esmaeili, Fereshteh Zohari
Dep. Of BIol., Med. Plants and Drug research Inst., Shahid Beheshti Univ., Iran

P27

Nanoparticle therapynitroxyl radicals in nanoparticle enhance therapeutic efficiency
Yukio Nagasaki1,2,3,4,5, Toru Yoshitomi1,2, Yuki Ozaki1,2, Kazuko Toh1,2, Yutaka Ikeda2,4
Tsukuba Research Center for Interdisciplinary Materials Sci., Univ. of Tsukuba, 2Grad. Sch. ofPure and Applied Sci., 3Master's Sch. of Med. Sci., 4Center for Tsukuba Advanced Research Alliance,
5
Satellite Laboratory of International Center for Materials Nanoarchitechtonics, MINS, Japan1

P28

Tocotrienol modulated oxidative stress response in lymphocyte by protecting against cell
death
Chin Siok Fong, Wan Zurinah Wan Ngah
Dept. of Biochemistry, Fac. of Med., Univ. Kebangsaan Malaysia, Malaysia

P29

Kinetics of free-radical-scavenging rates of vitamin E in membranes
Kenji Fukuzawa1, Akira Shibata1, Aya Ouchi2, Shin-ichi Nagaoka2, Kazuo Mukai21

P30

Fac. of Pharmacy, Yasuda Womens Univ., 2Fac. of Sci., Ehime Univ., Japan

Cytoprotective effects of α-tocopherol against glutamate-induced cell deathin immature primarycortical neuron cultures: Tocopherols and tocotrienols exertsimilar effects by antioxidant
function
Yoshiro Saito1, Noriko Noguchi1, Etsuo Niki2
Dept. of Med. Life Sys., Fac. of Life Med. Sci., Doshisha Univ., 2Health Res. Ins., Nat. Ins. ofAdv. Ind. Sci. (AIST), Japan

1－ 12 －

P31

Free radical scavenging property of few plants from Tribal areas of Southern Orissa, India.
Rojita Mishra, Satpal Singh Bisht
Roland Inst. of Pharmaceutical Sci., India

P32

Peroxinitrite scavenging activity of antioxidative synthetic uric acid analogs.
Kyoko Takahashi, Mai Ito, Daisuke Yasuda, Shigeo Nakamura, Tadahiko Mashino
Fac. of Pharmacy, Keio Univ., Japan

P33

Role of endogenous hydrogen sulfide in hepatic oxidative damage in rats with water-immersion
restraint stress
Yoshiji Ohta1, Shingo Kaida2, Yoichiro Imai3, Koji Ohashi4, Minoru Kawanishi2
Dept. of Chem., Fujita Health Univ. Sch. of Med., 2Dept. of Anesthesiol., Fujita Health Univ. Sch.
of Med., Japan, 3Dept. of Biochem., Fac. of Clin. Engineer., Fujita Health Univ. Sch. of HealthSci., Japan, 4Dept. of Clin. Biochem., Fac. of Med. Tech., Fujita Health Univ. Sch. of Health Sci.,
Japan
1

P34

Piper betle induces cytoprotective genes via Nrf2-ARE pathway in young and old mice
Yasmin Anum Mohd Yusof1, Wan Nuraini Wan Hasan1, Thuan Bui2, Suzana Makpol1, Wan Zurinah
Wan Ngah1
Dept of Biochemistry, Fac. of Med., Univ. Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz,
Kuala Lumpur, 2i-DNA Biotechnology Pte Ltd, Singapore

1

P35

Prevention of hepatic ischemia/reperfusion injury by intravenous injection of platinum
nanoparticles in mice
Kentaro Fukui1, Hidemasa Katumi1, Noriko Kitamura1, Haruka Ishikura1, Kanako Sato1, Shotaro
Nakahara1, Masataka Sano2, Munetaka Oyama3, Toshiyasu Sakane1, Akira Yamamoto1
Kyoto Pharmaceutical Univ., 2Ceramics Craft Co. Ltd, 3Grad. Sch. of Engineering, Kyoto Univ.,
Japan

1

P36

Deficiency of Bach1 ameliorates dextran sodium sulfate (DSS)-induced colitis in mice
Toshifumi Tsuji1, Yuji Naito1, Tomohisa Takagi1, Kazuhiko Uchiyama1, Akihito Harusato1, Osamu
Handa1, Hiroshi Ichikawa1, Akihiko Muto2, Kazuhiko Igarashi2, Toshikazu Yoshikawa1
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., 2Dept. of Biochemistry,
Tohoku Univ. Grad. Sch. of Med., Japan
1

P37

Prevention of reactive oxygen species-mediated pulmonary injury by intrapulmonary
administration of platinum nanoparticles in rats
Hidemasa Katsumi1, Kentaro Fukui1, Noriko Kitamura1, Haruka Ishikura1, Kanako Sato1, Shoko
Maruyama1, Masataka Sano2, Munetaka Oyama3, Toshiyasu Sakane1, Akira Yamamoto1
Kyoto Pharmaceutical Univ., 2Ceramics Craft Co. Ltd, 3Dept. of Material Chemistry, Grad. Sch.
of Engineering, Kyoto Univ., Japan

1－ 13 －

P38

α-Tocopherol status and expression of α-tocopherol transfer protein in type 2 diabetic GotoKakizaki rats
Hiroshi Miyazaki1,2, Kimitaka Takitani1, Hiroshi Tamai1
1

P39

Dept. of Pediatrics, Osaka Med. Coll., 2Dept. of Pediatrics, Osaka Rosai Hosp., Japan

Protection of aged black garlic against oxidative stress in rats fed high cholesterol diet.
Hyo Jin Kim, Mee Ree Kim
Dept. of Food and Nutr., Chungnam Nat'l Univ., Korea

P40

Aged black garlic protects against alcohol-induced oxidative liver damage in ratsJi Yeon Lee, Mee Ree Kim
Dept. of Food and Nutr., Chungnam Nat'l Univ., Korea

P41

Does an aqueous extract of cactus Opuntia ficus indica possess regulatory effect on oxidative
stress induced by water immersion in gerbils?
Gladis Coral1, Margarita Diaz1, Alberto Huberman1, Jose L Silencio1, Armando Gamboa1, Jackeline
Capistran2, Fernanda Flores2, Rebeca Ramirez2, Antonio Diaz3
Inst. Nat'l de Nutricion Salvador Zubiran, 2Facultad de Quimica, UNAM, 3Facultad de Veterinaria
y Zootecnia, UNAM, Mexico
1P42

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairment in the
Ts65Dn mouse model of Down syndrome
Mototada Shichiri1,2, Yasukazu Yoshida1, Yoshihisa Hagihara1, Hiroshi Tamai2, Etsuo Niki1
Stress Response Resesrch Group, Health Research Inst., Nat'l Inst. of Advanced Industrial Sci.
and Tec. (AIST), 2Dept. of Pediatrics, Osaka Med. Coll., Japan1

P43

Differential responses to blood pressure and oxidative stress in streptozotocin-treatedspontaneously hypertensive and Wistar-Kyoto rats: Differential effects of antioxidant (honey)treatment
Omotayo O. Erejuwa1, Siti A A. Sulaiman1, Mohd S Ab Wahab1, Kuttulebbai K Sirajudeen1, Md
Salzihan Md Salleh1, Sunil Gurtu2
Dept. of Pharmacology, Sch. of Med. Sci., Univ. Sains Malaysia., 2Sch. of Med. and Health Sci.,
Monash Univ. Sunway Campus, Malaysia

1

P44

Effects of spirulina on non-alcoholic steatohepatitis through anti-oxidative and anti-inflammatory
mechanisms
Wing Pak1, Manaka Mine1, Mitsumasa Mankura1, Toru Egashira1, Shigeru Okada1, Akitane Mori1,
Hiromu Kawasaki1, Yasumasa Kodo2, Fusako Takayama1
Grad. Sch. of Med., Dentistry, and Pharmaceutical Sci., Okayama Univ., 2Spirulina Bio-Lab. Co.,
Ltd., Japan

1－ 14 －

P45

Effect of oyster preparation and its constitutional n-3 polyunsaturated fatty acid on NASH
through redox balance regulation
Chengzhu Zhao, Mitsumasa Mankura, Toru Egashira, Hiromu Kawasaki, Shigeru Okada, Akitane
Mori, Fusako Takayama
Grad. Sch. of Med., Dentistry and Pharmaceutical Sci., Okayama Univ., JapanP46

A vitamin E analog (γ-Tocopherol-N, N-dimethylglycine ester) is a potent radiation mitigatoragainst bone marrow death of mice induced by whole body irradiation of X-rays and carbonbeams
Kazunori Anzai1,2, Megumi Ueno2, Nobuo Ikota3, Jiro Takata4
Nihonn Pharmaceutical Univ., 2Nat'l Inst. of Radiological Sci., 3Sch. of Pharmacy, Shujitsu Univ.,
Fac. of Pharmaceutical Sci., Fukuoka Univ., Japan

1
4

P47

Disuse muscle atrophy is suppressed by antioxidative flavonoid quercetin
Rie Mukai1, Takeshi Nikawa2, Hisao Nemoto3, Hironori Yamamoto4, Eiji Takeda4, Yoshichika
Kawai1, Junji Terao1
Dept. of Food Sci., Inst. of Health Biosciences, the Univ. of Tokushima Grad. Sch., 2Dept. of Nutr.
Physiology, Inst. of Health Biosciences, the Univ. of Tokushima Grad. Sch., 3Dept. of Pharmaceutical
Chemistry, Inst. of Health Biosciences, the Univ. of Tokushima Grad. Sch., 4Dept. of Clinical Nutr.,
Inst. of Health Biosciences, the Univ. of Tokushima Grad. Sch., Japan1

P48

The role of aldehyde reductase in biosynthesis of ascorbic acid in mice
Motoko Takahashi1, Satoshi Miyata2, Junichi Fujii3, Shigemitsu Ueyama2, Motoko Araki1,
Tomoyoshi Soga4, Reiko Fujinawa5, Naoyuki Taniguchi5, Yoshio Kuroki1
Dept. Biochem., Sapporo Med Univ, 2Dept. Internal Med., Kobe Univ. Grad. Sch. Med., 3Dept.
Biochem., Yamagata Univ. Sch. Med., 4Inst. Adv. Biosci., Keio Univ. Disease Glycomics Team,RIKEN, Japan
1

P49

Toxicity of alpha-synuclein in dopaminergic cells: oxidative modification and a candidate oftherapeutic target for Parkinson’s disease
Kazuhiro Nakaso, Tatsuya Matsura
Div. of Med. Biochem., Dep. of Pathophysiol. and Therapeut. Sci., Fac., of Med., Tottori Univ.,
Japan

P50

Immunohistochemical detection of serotonin oxidation products in human atherosclerotic
lesionYoji Kato1, Yoko Miura2, Michitaka Naito3, Noritoshi Kitamoto1, Anthony J Kettle4
Sch. of Human Sci. and Environment, Univ. of Hyogo, 2Dept. of Health & Nutr., Nagoya Bunri
Univ., 3Div. of Nutr. & Health, Sch. and Grad. Sch. of Life Studies, Sugiyama Jogakuen Univ.,
Japan, 4Free Radical Research Group, Dept. of Pathology, Univ. of Otago, New Zealand1－ 15 －

P51

Planar catechin derivatives incorporating basic amino acids for chemoprevention of oxidative
stress related diseases
Kiyoshi Fukuhara1, Ikuo Nakanishi2, Kohei Imai3, Akiko Ohno1, Asao Nakamura3, Kazunori Anzai2,
Toshihiko Ozawa4, Naoki Miyata5, Haruhiro Okuda1
Nat'l Inst. of Health Sci., 2Nat'l Inst. of Radiological Sci., 3Shibaura Inst. of Tec., 4Yokohama Coll.
of Pharmacy Nagoya City Univ., Japan

1

P52

Plasma protein carbonyl contents increased as plasma vitamin C concentration decreased inemergency room patients
Hee-Shang Youn1, Hee-Jeong Park1, Ji-Hyun Seo1, Jae-Youn Lim1, Chan-Hoo Park1, Hyang-Ok
Woo1, Myung-Je Cho2, Kwang-Ho Rhee2
Dept of Pediatrics, Gyeongsang Nat'l Univ. Sch. of Med., 2Dept of Microbiology, Gyeongsang
Nat'l Univ. Sch. of Med., Korea
1

P53

ASA induced ROS production and protein expression in small intenstinal epithelial cells.
Akifumi Fukui, Yuji Naito, Osamu Handa, Qin Ying, Natsuko Hayashi, Kazuhiko Uchiyama,
Tomohisa Takagi, Nobuaki Yagi, Satoshi Kokura, Toshikazu Yoshikawa
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., Japan

P54

Analysis of halogenated proteins in indomethacin-induced intestinal injury
Hiroyuki Yoriki1, Yuji Naito1, Tomohisa Takagi1, Osamu Handa1, Tomoko Oya-Ito1, Kazuhiko
Uchiyama1, Hiroshi Ichikawa1, Yoji Kato2, Toshio Osawa3, Toshikazu Yoshikawa1
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., 2Sch. of Human Sci. andEnvironment, Univ. of Hyogo, 3Laboratory of Food and Biodynamics, Grad. Sch. of Bioagricultural
Sci., Nagoya Univ., Japan
1

P55

Polaprezinc protects small intestinal epithelial cell from aspirin-induced apoptotic stimuli.
Ying Qin, Yuji Naito, Osamu Handa, Natsuko Hayashi, Kazuhiko Uchiyama, Takeshi Ishikawa,
Tomohisa Takagi, Nobuaki Yagi, Satoshi Kokura, Toshikazu Yoshikawa
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., Japan

P56

Detection of hexanoyl-lysine (HEL)-modified proteins in indomethacin induced intestinal injury
in rats
Shinya Yamada1, Yuji Naito1, Tomohisa Takagi1, Hitomi Okada1, Katsura Mizushima1, Kazuhiko
Uchiyama1, Osamu Handa1, Koji Kato2, Toshihiko Osawa3, Toshikazu Yoshikawa1
Molecular Gastroenterology and Hepatology, Kyoto Pref. Univ. of Med., Japan, 2Sch. of Human
Sci. and Environment, Univ. of Hyogo, Japan, 3Dept. of Nutr. Sci., Aichi Gakuin Univ., Japan
1

P57

The iron-uptake system for the antioxidant ability of Helicobacter pylori
Hitoshi Tsugawa, Hidekazu Suzuki, Kenro Hirata, Juntaro Matsuzaki, Sawako Okada, Seiichiro
Fukuhara, Yoshimasa Saito, Toshifumi Hibi
Div. of Gastroenterol. Hepatol., Dept. of Internal Med., Keio Univ. Sch. of Med., Japan－ 16 －

P58

Oxidative stress and nanoparticle
Masanori Horie, Shigehisa Endoh, Haruhisa Kato, Katsuhide Fujita, Shinichi Kinugasa, Keiko
Nishio, Lilian K Komaba, Etsuo Niki, Yasukazu Yoshida, Hitoshi Iwahashi
Nat'l Inst. of Advanced Industrial Sci. and Tec. (AIST), Japan

P59

Differential oxidative stress in nuclei revealed by organelle-specific redox spin probe
Hidehiko Nakagawa1,2, Mamiko Ikeda1, Takayoshi Suzuki1, Naoki Miyata1
1

P60

Grad. Sch. of Pharmaceutical Sci., Nagoya City Univ., 2PRESTO, JST, Japan

Combination nanotherapy for drug delivery by antioxidative nanocarrier
Pennapa Chonpathompikunlert1, Toru Yoshitomi1, Junkyu Han2, Kazuko Toh1, Hiroko Isoda2,
Yukio Nagasaki1
Dept. of Materials Sci., Grad. Sch. of Pure and Applied Sci., Tsukuba Research Center forInterdisciplinary Materials Sci. (TIMS), Univ. of Tsukuba, 2Grad. Sch. of Life and Environmental
Sci., The Alliance for Research on North Africa, Univ. of Tsukuba, Japan
1

P61

Indoxyl sulfate and guanidine succinic acid induce mitochondrial superoxide production
Aki Hirayama1, Shigeru Owada2, Hirofumi Matsui3, Yumiko Nagano3, Tsuyoshi Kaneko3, Kanho
Rai3, Atsushi Ueda4, Kazumasa Aoyagi1
Center for Integrative Med., Tsukuba Univ. of Tec., Japan, 2Asao Clinic, Japan, 3Grad. Sch. forComprehensive Human Sci., Univ. of Tsukuba, 4Namegata District General Hosp., Japan1

P62

Two electron oxidation of cefazolin antibiotic gives cefazolinsulfoxide and its cleavage yields
5-methyl-1, 3, 4-thiadiazol-2-thiol
Akio Fujisawa, Satoru Ando, Yorihiro Yamamoto
Sch. of Bioscience and Biotechnology, Tokyo Univ. of Tec., Japan－ 17 －