Interoffice Cnt’responllence

3~

Subject:

19, 1977~.J.

In o~der ~o he~p you with your preparations forN~r 7 to ~ ~rate ~s~nstb~ltty ~lCcee,
cop~es of ~ tr~ar~ ~8 ~ ~ ~he last~ttee ~ ~ 8, 1977, ~ in February.

encl.

3MA10067215

Trial Exhibit 1202

3M_MN00000479

1145.0001

ORGANIC FLUORINE C~POUNI)S IN BLOOI)CHRONOLOGYAUGUST 22,, 1975
AUGUST 25, 1975

- DR. J. D. LA ZERTE RECEIVES CALL FROM
W. S. GUY OF UNIVERSITY OF ROCHESTER.
W, S, GUY, D. R. TAVES, AND W, S. BREY,JR.
PRESENT A PAPER AT CHICA.r’.,-O ACS MEETING
ENTITLED "CHARACTERISTICS AND

CONCENTRATIONS OF ORGANIC FLUORO COMPOUNDSFOUND IN HUMAN TISSUES,"SEPTEMBER 17-21, 1975

CENTRAL RESEARCH ANALYTICAL TO COMPAP,E
C7FIsCOOH AND CBF17SO~H ~R SPECTRA WITH
THAT REPORTED BY GUY ET AL.

SEPT~ER 22, 1975TAVES CALLS J. D. LA ZERTE TO DETE~INE
IF 3M WILL FURTHER ANALYZE THEIR SAMPLE
OF FLUOROCHEMiCAL. ALSO ASKS 3M TOOPEN CONTENTS OF FDA PETITION ON"SCOTCHBAN."OCTOBER, 1975

CENTRAL RESEARCH N~LYTICAL AGREES TO
DETE~INE QUANTITY AND CHARACTER OFORGANIC FLUORINE COMPOUNDS I~i HUMANBLOOD.

NOVEMBER 6, 1975

CENTRAL RESEARCH REPORTS THATCBF17SO3H SPECTRA MATCHES THATPRESE~T{D BY GUY, ET AL.

DECEMBER 16, 1975

LA ZERTE, FREIER, AND LONG OF 3M
VISIT GUY AND TAVES AT THE UNIVERSITY
OF ROCHESTER. ~M PROPOSES, AND GUYAND TAVES AGREE THAT 3M WILL ATTEMPTTO ISOLATE AND IDENTIFY ORGANIC FLUORINECOMPOUNDS IN HUMAN BLOOD.

3MA 10067216

3M MNO00004801145.0002

CHRONOLOGY - PAGE 2FEBRLIARY 17, 1976

CENTRAL RESEARCH ANALYTICAL DEVELOPSAN ACCURATE ANALYI’ICAL METHOD FORDETERMINING PARTS PER BILLION QUANTITIESOF ORGANIC FLUORINE COMPOUNDS IN HUMANBLOOD. METHOD TESTED ON BLOOD FROMAMERICAN RED CROSS AND VALUE AGREESWITH THOSE IN LITERATURE.

APRIL 14, 1976

FOUR ~RATORY PEP,SONNEL HAVE BLOODSAMPLES ANALYZED. CONCENT~TION OFORGANIC FLUORINE COMPOO~S IN SOMEPERSOIWNEL 100 TIMES NORMAL.

JUNE 29, 1976- SOME CH~LITE PERSONNEL SHOW ORGANICFLUORINE COMPOUNDS AT 1,000 TIMES NORMAL.

AUGUST 23,. 1976

- CORDOVA PERSONNEL E~POSED TO FLUOROCHEMICALS HAVE UP TO 50 TIMES NORMALVALUES,AUGUST 26, 1976

CENTRAL RESEARCH ISOLATES AND IDENTIFIESORGANIC FLUORINE COMPOUNDS FROM BLOODOF CHEMOLITE PERSON AS CTF15COOH.

SEPTEMBER 9, 1976

MICE FED "SCOTCHBAN." HAD q, o00 TIMESNORMAL ORGANIC FLUORINE COMPOUP~S.

SEPTEMBER 17, 1976

- CFIF SO-," IDENTIFIED AS ORG~IO FLUORINEOCTOBER 8, 1976

- DECATUR PLANT PERSONNEL FOUND TO HAVE UPTO 300 TIMES NORMAL LEVELS.
INDIVIDUALS EXPOSED TO FLUOROCHEMICALSOVER 20 YEARS AGO HAVE NORMAL ORGANICFLUORINE COMPOUND LEVELS.

3MA10067217

3M MN00000481

1145.0003

CHRONOLOGY - PA6E 3
OCTOBER 28, 1976

- DR, LEON SINGER OF THE BIOCHEMISTRY
DEPART~NT. UNIVERSITY OF MINNESOTA.
CALLS TO OBTAIN SAMPLES OF CTFlsCOOH.__DR, SINGER REPORTS THAT HE HAS HADCONVERSATIONS glTH TAVES. ALSO REPORTS
THAT ANIP,ALS FED INORGANIC FLUORIDESHOW INCREASES IN ORGANIC FLUORINEBLOOD ~WEL,

3 MA 10067218

3M MN00000482

1145.0004

OR6ANIC FLUOR]I~ COMPOUNDS IN BLOODSTATUS AT 94
NO EVIDENCE NOW OF RELATED HEALTH PROBLEMS,

3M ~ICAL DEPARTMENT INITIATING PR{)6~I TO STUDY BLOODCHEMISTRY OF EXPOSED PERSONNEL,NO EVIDENCE THAT THE PROBLEM EXISTS WITH 3M’S CUSTOMERS.
FUNDS ARE BUDGETED TO CONTINUE THE PROGRAM STUDY UNTILWE ARE SATISFIED:(A,) THAT THERE IS NO HEALTH HAZARD INCURRED BY
3M EMPLOYEES; AND,(e.) THAT THE CONTINUED SALE OF OUR FLUOROCHE~IICALSFOR VARIOUS PURPOSES DOES NOT ENDANGER THEPUBLI C’S HEALTH.

3MA10067219I II

3M MN00000483

1145.0005

FLUOR]NE C~ENT OF BLOOD SERI.I~1,

LITERATURE VALUESORGANICINORGANICFLUORINE

FLUORINE

P,P.B,
2 - 1~0

P.P,B,

Ave. 30~ - 170
AvE. 20

10 - 80

qO - 60

2,

3M CONTROLS3.

LABORATORY BUILDING 2~6

q30 - 3,100

30 - 360

4.

CORDOVA

160 - 630

50 - 870

5.

CHEHOLITE

510 - 38,800

50 - gO

6,DECATUR

150 - %840

40 - 210

3MAt 0067220

3M MN00000484

1145.0006

SOURCES OF FLUORINETOOTHPASTE, I)EIITAL CARE,FLUORIDIZED WATERORGANIC
3M~3 CF2 CF2 CF2 CF2 CF2 CF2COOfl
CF3 CF2 CF2 CF2 CF2 CF2 CF2 CF2 S03H

OTHERS

STEROIDSTRANQUILIZERSANESTHETICSHERBICIDESTEFLONAEROSOL PROPELLANTSREFRIGERANTS

3MA10067221

3M MN00000485

1145.0007