D-Plex Small RNA DNBSEQ™ Kit for MGI
C05030051
Flyleaf
Date of compilation: 2021-01-12

Bill of materials
Name of substance

Identifier

Numberof piecesClassificationacc. to GHS

Pictograms

Page

Dephosphorylation buffer (DB)1

2–9

Dephosphorylation reagent (DR)1

10 – 18

Tailing reagent (TR)1

19 – 27

Small Tailing buffer (STB)1

28 – 35

RT Primer H DNBSEQ (RTPH)

1

36 – 43

RT Primer M DNBSEQ(RTPM)

1

44 – 51

Reverse Transcription Reagent (RTR)

1

52 – 59

Reverse Transcription
Buffer (RTB)1

60 – 67

Template Switching Oligo DNBSEQ (TSO)1

68 – 75

PCR master mix (PCRMM)

1

76 – 84

Positive Control miRNA(CTL+)

1

85 – 92

ChIP-seq grade water1

93 – 100

United Kingdom

DIAGENODE 000592 KIT-07

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

Dephosphorylation buffer (DB)registration number (REACH)

not relevant (mixture)

product code(s)K14421001

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

explosive limits

not determinedvapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

12.6

revision: 2020-02-28

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation buffer (DB)version number: GHS 2.0
replaces version of: 2020-02-28 (GHS 1)

revision: 2020-02-28

SECTION 16: Other information
indication of changes (revised safety data sheet)sectionformer entry (text/value)

1.1

actual entry (text/value)safety-relevant

product code(s):K14421001

yesabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

Dephosphorylation reagent (DR)registration number (REACH)

not relevant (mixture)

product code(s)K14421002

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United Kingdom: en

page: 1 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierGB

glycerol

56-81-5

WEL

TWA
[ppm]

TWA
[mg/m³]

STEL
[ppm]

10

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion

source

mist

EH40/
2005

notation
Ceiling-C
mist
STEL
TWA

8.2

ceiling value is a limit value above which exposure should not occur
as mists
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified)

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourless

United Kingdom: en

page: 4 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determinedvapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidisers

United Kingdom: en

page: 5 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

10.6

date of compilation: 2020-02-28

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

United Kingdom: en

page: 6 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

12.5

date of compilation: 2020-02-28

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

United Kingdom: en

page: 7 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

EH40/2005

EH40/2005 Workplace exposure limits (http://www.nationalarchives.gov.uk/doc/open-government-licence/)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

ppm

Parts per million

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)STEL

Short-term exposure limit

TWA

Time-weighted averagevPvB

Very Persistent and very Bioaccumulative

WEL

Workplace exposure limit

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).
United Kingdom: en

page: 8 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Dephosphorylation reagent (DR)version number: GHS 1.0

date of compilation: 2020-02-28

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 9 / 9Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade nameTailing reagent (TR)registration number (REACH)

not relevant (mixture)

product code(s)K14421004

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United Kingdom: en

page: 1 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierGB

glycerol

56-81-5

WEL

TWA
[ppm]

TWA
[mg/m³]

STEL
[ppm]

10

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion

source

mist

EH40/
2005

notation
Ceiling-C
mist
STEL
TWA

8.2

ceiling value is a limit value above which exposure should not occur
as mists
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified)

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourless

United Kingdom: en

page: 4 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determinedvapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidisers

United Kingdom: en

page: 5 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

10.6

date of compilation: 2020-02-28

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

United Kingdom: en

page: 6 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

12.5

date of compilation: 2020-02-28

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

United Kingdom: en

page: 7 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

EH40/2005

EH40/2005 Workplace exposure limits (http://www.nationalarchives.gov.uk/doc/open-government-licence/)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

ppm

Parts per million

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)STEL

Short-term exposure limit

TWA

Time-weighted averagevPvB

Very Persistent and very Bioaccumulative

WEL

Workplace exposure limit

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).
United Kingdom: en

page: 8 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Tailing reagent (TR)version number: GHS 1.0

date of compilation: 2020-02-28

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 9 / 9Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

Small Tailing buffer (STB)

registration number (REACH)

not relevant (mixture)

product code(s)K14421005

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

vapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Small Tailing buffer (STB)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

RT Primer H DNBSEQ (RTPH)

registration number (REACH)

not relevant (mixture)

product code(s)K15821001

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
of no significance

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

6.3

date of compilation: 2021-01-12

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
physical stateliquidcolourcolourlessodour

odourlessmelting point/freezing point

not determinedboiling point or initial boiling point and boilingrange

not determined

flammability

non-combustible

lower and upper explosion limit

not determinedflash point

not determined

auto-ignition temperature

not determineddecomposition temperature

not relevant

pH (value)

not determinedkinematic viscosity

not determinedsolubility(ies)not determinedpartition coefficientpartition coefficient n-octanol/water (log value)

this information is not available

vapour pressure

not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

density and/or relative density

9.2

density

not determinedparticle characteristics

no data available

other information
information with regard to physical hazard classes

hazard classes acc. to GHS (physical hazards): notrelevant

other safety characteristics

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on hazard classes as defined in Regulation (EC) No 1272/2008
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

11.2

information on other hazards
there is no additional information.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

endocrine disrupting properties
information on this property is not available.

12.7

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)

none

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

maritime transport in bulk according to IMO instruments
the cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN) - additional
information
not assigned

International Maritime Dangerous Goods Code (IMDG) - additional information
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR) - additional information
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer H DNBSEQ (RTPH)
version number: GHS 1.0

date of compilation: 2021-01-12

abbr.

descriptions of used abbreviations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods Code

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2020/878/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

RT Primer M DNBSEQ (RTPM)

registration number (REACH)

not relevant (mixture)

product code(s)K15821002

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
of no significance

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

6.3

date of compilation: 2021-01-12

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
physical stateliquidcolourcolourlessodour

odourlessmelting point/freezing point

not determinedboiling point or initial boiling point and boilingrange

not determined

flammability

non-combustible

lower and upper explosion limit

not determinedflash point

not determined

auto-ignition temperature

not determineddecomposition temperature

not relevant

pH (value)

not determinedkinematic viscosity

not determinedsolubility(ies)not determinedpartition coefficientpartition coefficient n-octanol/water (log value)

this information is not available

vapour pressure

not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

density and/or relative density

9.2

density

not determinedparticle characteristics

no data available

other information
information with regard to physical hazard classes

hazard classes acc. to GHS (physical hazards): notrelevant

other safety characteristics

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on hazard classes as defined in Regulation (EC) No 1272/2008
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

11.2

information on other hazards
there is no additional information.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

endocrine disrupting properties
information on this property is not available.

12.7

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)

none

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

maritime transport in bulk according to IMO instruments
the cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN) - additional
information
not assigned

International Maritime Dangerous Goods Code (IMDG) - additional information
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR) - additional information
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

RT Primer M DNBSEQ (RTPM)
version number: GHS 1.0

date of compilation: 2021-01-12

abbr.

descriptions of used abbreviations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods Code

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2020/878/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

Reverse Transcription Reagent (RTR)

registration number (REACH)

not relevant (mixture)

product code(s)K15821004

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
of no significance

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

6.3

date of compilation: 2021-01-12

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierGB

glycerol

56-81-5

WEL

TWA
[ppm]

TWA
[mg/m³]
10

STEL
[ppm]

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion

source

mist

EH40/
2005

notation
Ceiling-C
mist
STEL
TWA

United Kingdom: en

ceiling value is a limit value above which exposure should not occur
as mists
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified)

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

8.2

date of compilation: 2021-01-12

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
physical stateliquidcolourcolourlessodour

odourlessmelting point/freezing point

not determinedboiling point or initial boiling point and boilingrange

not determined

flammability

this material is combustible, but will not ignite
readily

lower and upper explosion limit

not determinedflash point

not determined

auto-ignition temperature

not determineddecomposition temperature

not relevant

pH (value)

not determinedkinematic viscosity

not determinedsolubility(ies)not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

date of compilation: 2021-01-12

partition coefficientpartition coefficient n-octanol/water (log value)

this information is not available

vapour pressure

not determined

density and/or relative density

9.2

density

not determinedparticle characteristics

no data available

other information
information with regard to physical hazard classes

hazard classes acc. to GHS (physical hazards): notrelevant

other safety characteristics

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidisers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on hazard classes as defined in Regulation (EC) No 1272/2008
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

date of compilation: 2021-01-12

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

11.2

information on other hazards
there is no additional information.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

endocrine disrupting properties
information on this property is not available.

12.7

other adverse effects
data are not available.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)

none

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

maritime transport in bulk according to IMO instruments
the cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN) - additional
information
not assigned

International Maritime Dangerous Goods Code (IMDG) - additional information
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR) - additional information
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Reagent (RTR)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

EH40/2005

EH40/2005 Workplace exposure limits (http://www.nationalarchives.gov.uk/doc/open-government-licence/)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods Code

PBT

Persistent, Bioaccumulative and Toxic

ppm

Parts per million

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)STEL

Short-term exposure limit

TWA

Time-weighted averagevPvB

Very Persistent and very Bioaccumulative

WEL

Workplace exposure limit

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2020/878/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

Reverse Transcription Buffer (RTB)

registration number (REACH)

not relevant (mixture)

product code(s)K15821005

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
of no significance

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

6.3

date of compilation: 2021-01-12

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierGB

glycerol

56-81-5

WEL

TWA
[ppm]

TWA
[mg/m³]
10

STEL
[ppm]

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion

source

mist

EH40/
2005

notation
Ceiling-C
mist
STEL
TWA

United Kingdom: en

ceiling value is a limit value above which exposure should not occur
as mists
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified)

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

8.2

date of compilation: 2021-01-12

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
physical stateliquidcolourcolourlessodour

odourlessmelting point/freezing point

not determinedboiling point or initial boiling point and boilingrange

not determined

flammability

this material is combustible, but will not ignite
readily

lower and upper explosion limit

not determinedflash point

not determined

auto-ignition temperature

not determineddecomposition temperature

not relevant

pH (value)

not determinedkinematic viscosity

not determinedsolubility(ies)not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

date of compilation: 2021-01-12

partition coefficientpartition coefficient n-octanol/water (log value)

this information is not available

vapour pressure

not determined

density and/or relative density

9.2

density

not determinedparticle characteristics

no data available

other information
information with regard to physical hazard classes

hazard classes acc. to GHS (physical hazards): notrelevant

other safety characteristics

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidisers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on hazard classes as defined in Regulation (EC) No 1272/2008
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

date of compilation: 2021-01-12

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

11.2

information on other hazards
there is no additional information.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

endocrine disrupting properties
information on this property is not available.

12.7

other adverse effects
data are not available.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)

none

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

maritime transport in bulk according to IMO instruments
the cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN) - additional
information
not assigned

International Maritime Dangerous Goods Code (IMDG) - additional information
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR) - additional information
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Reverse Transcription Buffer (RTB)
version number: GHS 1.0

date of compilation: 2021-01-12

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

EH40/2005

EH40/2005 Workplace exposure limits (http://www.nationalarchives.gov.uk/doc/open-government-licence/)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods Code

PBT

Persistent, Bioaccumulative and Toxic

ppm

Parts per million

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)STEL

Short-term exposure limit

TWA

Time-weighted averagevPvB

Very Persistent and very Bioaccumulative

WEL

Workplace exposure limit

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2020/878/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade nameTemplate Switching Oligo DNBSEQ (TSO)

registration number (REACH)

not relevant (mixture)

product code(s)K15821003

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
of no significance

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

6.3

revision: 2021-01-12

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
physical stateliquidcolourcolourlessodour

odourlessmelting point/freezing point

not determinedboiling point or initial boiling point and boilingrange

not determined

flammability

non-combustible

lower and upper explosion limit

not determinedflash point

not determined

auto-ignition temperature

not determineddecomposition temperature

not relevant

pH (value)

not determinedkinematic viscosity

not determinedsolubility(ies)not determinedpartition coefficientpartition coefficient n-octanol/water (log value)

this information is not available

vapour pressure

not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

density and/or relative density

9.2

density

not determinedparticle characteristics

no data available

other information
information with regard to physical hazard classes

hazard classes acc. to GHS (physical hazards): notrelevant

other safety characteristics

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on hazard classes as defined in Regulation (EC) No 1272/2008
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

11.2

information on other hazards
there is no additional information.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

endocrine disrupting properties
information on this property is not available.

12.7

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)

none

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

maritime transport in bulk according to IMO instruments
the cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN) - additional
information
not assigned

International Maritime Dangerous Goods Code (IMDG) - additional information
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR) - additional information
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information
indication of changes (revised safety data sheet)sectionformer entry (text/value)

actual entry (text/value)safety-relevant

1.1

product code(s):Template Switching Oligo DNBSEQ (TSO)

product code(s):K15821003

yes

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Template Switching Oligo DNBSEQ (TSO)
version number: GHS 2.0
replaces version of: 2021-01-12 (GHS 1)

revision: 2021-01-12

abbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods Code

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2020/878/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

PCR master mix (PCRMM)

registration number (REACH)

not relevant (mixture)

product code(s)K14421011

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United Kingdom: en

page: 1 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierGB

glycerol

56-81-5

WEL

TWA
[ppm]

TWA
[mg/m³]

STEL
[ppm]

10

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion

source

mist

EH40/
2005

notation
Ceiling-C
mist
STEL
TWA

8.2

ceiling value is a limit value above which exposure should not occur
as mists
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified)

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourless

United Kingdom: en

page: 4 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determinedvapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidisers

United Kingdom: en

page: 5 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

10.6

date of compilation: 2020-02-28

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

United Kingdom: en

page: 6 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

12.5

date of compilation: 2020-02-28

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

United Kingdom: en

page: 7 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

EH40/2005

EH40/2005 Workplace exposure limits (http://www.nationalarchives.gov.uk/doc/open-government-licence/)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

ppm

Parts per million

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)STEL

Short-term exposure limit

TWA

Time-weighted averagevPvB

Very Persistent and very Bioaccumulative

WEL

Workplace exposure limit

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).
United Kingdom: en

page: 8 / 9

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

PCR master mix (PCRMM)
version number: GHS 1.0

date of compilation: 2020-02-28

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 9 / 9Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifiertrade name

Positive Control miRNA (CTL+)

registration number (REACH)

not relevant (mixture)

product code(s)K14421013

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

vapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification according to GHS (1272/2008/EC, CLP)
this mixture does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

Positive Control miRNA (CTL+)
version number: GHS 1.0

date of compilation: 2020-02-28

SECTION 16: Other informationabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United Kingdom: en

page: 8 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1

1.2

product identifier
identification of the substance

ChIP-seq grade water

registration number (REACH)

this information is not available

CAS number

7732-18-5

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison centre
country

nametelephone

United Kingdom

National Poisons Information Service

111

SECTION 2: Hazards identification
2.1

classification of the substance or mixture
classification according to Regulation (EC) No 1272/2008 (CLP)
this substance does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

2.2

label elements
labelling according to Regulation (EC) No 1272/2008 (CLP)
not required

2.3

other hazards
results of PBT and vPvB assessment
according to the results of its assessment, this substance is not a PBT or a vPvB.

United Kingdom: en

page: 1 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 3: Composition/information on ingredients
3.1

substancesname of substance

ChIP-seq grade water

identifiers
CAS No7732-18-5

molecular formula

H2O

molar mass

18.02 g/mol

SECTION 4: First aid measures4.1

description of first aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Firefighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, alcohol resistant foam, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. co-ordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United Kingdom: en

page: 2 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapours/dust/spray/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United Kingdom: en

page: 3 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolourcolourlessodour

odourlessother safety parameters
pH (value)

not determinedmelting point/freezing point

0 °C

initial boiling point and boiling range

100 °C

flash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

United Kingdom: en

page: 4 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

explosive limits

not determinedvapour pressure

not determined

density

not determinedvapour density

this information is not available

relative density

information on this property is not available

solubility(ies)- water solubility

miscible in any proportion

partition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidising properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

United Kingdom: en

page: 5 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 11: Toxicological information
11.1

information on toxicological effects
classification according to GHS (1272/2008/EC, CLP)
this substance does not meet the criteria for classification in accordance with Regulation No 1272/2008/EC.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitisation
shall not be classified as a respiratory or skin sensitiser.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

United Kingdom: en

page: 6 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 13: Disposal considerations
13.1

waste treatment methods
waste treatment-relevant information
recycling/reclamation of other inorganic materials.

sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packagingscompletely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot relevant

14.3

transport hazard class(es)

none

14.4

packing group

not assigned to a packing group

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN)
not subject to ADR, RID and ADN.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations/legislation specific for the substance or mixture

15.2

Chemical Safety Assessment
no Chemical Safety Assessment has been carried out for this substance.

United Kingdom: en

page: 7 / 8

Safety Data Sheetaccording to Regulation (EC) No. 1907/2006 (REACH)

ChIP-seq grade waterversion number: GHS 2.0
replaces version of: 2019-11-22 (GHS 1)

revision: 2019-12-23

SECTION 16: Other information
indication of changes (revised safety data sheet)sectionformer entry (text/value)

actual entry (text/value)safety-relevant

5.1

suitable extinguishing media:
not applicablesuitable extinguishing media:
water spray, alcohol resistant foam, BC-powder, carbon dioxide (CO2)

yes

5.1

unsuitable extinguishing media:
not applicableunsuitable extinguishing media:
water jetyesabbreviations and acronyms
abbr.

descriptions of used abbreviations

ADN

Accord européen relatif au transport international des marchandises dangereuses par voies de navigation
intérieures (European Agreement concerning the International Carriage of Dangerous Goods by Inland Waterways)

ADR

Accord européen relatif au transport international des marchandises dangereuses par route (European Agreement concerning the International Carriage of Dangerous Goods by Road)CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

CLP

Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

PBT

Persistent, Bioaccumulative and Toxic

REACH

Registration, Evaluation, Authorisation and Restriction of Chemicals

RID

Règlement concernant le transport International ferroviaire des marchandises Dangereuses (Regulations concerning the International carriage of Dangerous goods by Rail)vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
Regulation (EC) No 1272/2008 on classification, labelling and packaging of substances and mixtures. Regulation (EC) No.
1907/2006 (REACH), amended by 2015/830/EU.
transport of dangerous goods by road, rail and inland waterway (ADR/RID/ADN). International Maritime Dangerous Goods
Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

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