MEASUREMENT AND CONTROL OF BIOMEDICINEMANUFACTURING PROCESSESBIOSONIC
Single-use ultrasonic flowmeter for liquidsOUTLINE
BIOSONIC ultrasonic flowmeter is designed for measuring liquidflow rates in biopharmaceutical manufacturing processes. It consistsof BS detector and SFC converter. The wetted parts of the detector
have biocompatibility (USP Class VI, FDA, BSE/TSE free) using
gamma-sterilizable material (PSU) for single-use.
Thanks to our unique ultrasonic flow measurement technology
developed over the years, BIOSONIC can measure instantaneousand integrated flow rates with high accuracy without affecting liquids
that contain cells. The construction is simple and smooth with nomoving parts in the detector that would cause stress to liquids, andwith no sealing mechanism that would cause liquid components toaccumulate and leave residues. The detector cable is detachable
and easy to install for single-use.

FEATURES❑ Materials of wetted parts of the flow detector: Biocompatible (FDA,USP Class VI, no TSE/BS animal derived components), gammasterilizable (up to 50 kGy)
❑ Highly clean construction without causing stress to liquids orleaving residues❑ Wide rangeability
BS04SC		Range: 0 to 800 mL/min

APPLICATIONS❑ Noninvasive, highly accurate flow measurement of liquids inbiopharmaceutical manufacturing processes❑ Flow control by combining pumps, control valves, etc.
❑ Installation into single-use kits and systems

BS04		

Range: 0 to 3000 mL/min

BS06
Range: 0 to 8000 mL/min
BS10		

Range: 0 to 20 L/min

BS15		

Range: 0 to 50 L/min

BS20		

Range: 0 to 80 L/min❑ Liquids with kinematic viscosity of as high as 40 mm2/s can bemeasured.
❑ Accuracy: Within ±1% of the reading at flow velocity of 1 m/s ormore❑ Adjustment function to offset the effect on the measurement
values caused by a change in liquid temperature (optional)❑ CE marking

OPERATING PRINCIPLE
The measuring fluid flows into the U-shaped tube, changes direction
by 90 degrees twice, and goes out as shown in Figure 1. Twopiezoelectric transducers A and B are mounted at both ends ofthe measuring section. They emit and receive ultrasonic waves
alternately and measure the traveling times tA (A to B) and tB (B toA) through the liquid. Without flow, t A is equal to tB. With flow, t A
becomes shorter and tB longer in proportion to the flow rate. Thus,
calculating tB - tA gives the flow rate of the liquid. tA and tB dependon the size and shape of the tube and liquid viscosity. The actual flow
test data are stored in the linearizer in the converter, which enables
BIOSONIC to measure flow rates with high accuracy.

OUT

Piezoelectrictransducer A

Piezoelectrictransducer B

Travelling time tA❑ All the detectors are calibrated with the actual flow (water) at thetime of shipment.
❑ Soundness of the converter can be checked on site by using asimulator (optional).

Travelling time tB

INFigure 1 Operating principle
TG-F2038-E02
3rd edition Mar 2024 K
1st edition Aug 2020 K

BS□□/SFC4000-EV Single-use ultrasonic flowmeter for liquids

STANDARD SPECIFICATIONS
Model codeDetector• Measuring fluid: Liquids (without bubbles, no permeatingBS□□ □□04 SC		 or eroding PSU)

□□

□

□

Description
4 mm, high accuracy calibration

04

4 mm, standard accuracy

06

6 mm, standard accuracy

1010 mm, standard accuracy: 0 to 0.5 MPa1515 mm, standard accuracy• Fluid sound speed: 400 to 2500 m/s

2020 mm, standard accuracy• Fluid kinematic velocity: 0.3 to 40 mm2/s• Process connection: BS04SC• Fluid temperature: 2 to 60°C

• Ambient temperature: 0 to 50°C

• Fluid pressure

Metersize		 BS04

3/8” hose barb fitting		 BS06

3/8” hose barb fitting		 BS10

1/2” hose barb fitting		 BS153/4” hose barb fitting		 BS20

1” hose barb fitting• Wetted part material

Barb fitting
BS04SC, BS04, BS06
3/8” Barb fitting
BS10 1/2” Barb fitting
BS15 3/4” Barb fitting
BS20 1” Barb fitting

3/8” hose barb fitting: PSU (FDA, USP Class VI, no animal		 derived components, TSE/BS measures),		gamma-sterilizable

Processconnection

B

Cable length

5Cable leadout direction

5 m (Standard)Standard
Please consult for other directions.

ABlank Not provided

Special specifications/ZProvided• Maximum permissible dose : 50 kGy• Enclosure classification: IP65 (indoor use)

• Mass: Refer to Table 1.

• Output

Table 1. Sensor weight without cables
Model
BS04SC, BS04, BS06
BS10BS15BS201) Instantaneous flow rateWeight (g)Approx. 50
Approx. 60
Approx. 85
Approx. 130

Current output type			
Voltage output type			: Coaxial cable × 2: 5 m (standard)• Flow range: Refer to Table 2.
Flow range (L/min)
0 to 0.8
0 to 3.0
0 to 8.0
0 to 20
0 to 50
0 to 80

Connecting tube size
3/8”Barb fitting
3/8”Barb fitting
3/8”Barb fitting
1/2”Barb fitting
3/4”Barb fitting1”Barb fitting: Refer to Table 3.

Table 3. Accuracy and flow range
Model
BS04SC
BS04
BS06
BS10BS15BS20				 (load resistance: 1 MΩ or more)
2) Pulse output

Table 2. Flow range and connecting tube size

Flow velocity < 1m/s
Flow rate
Accuracy(L/min)(L/min)0 to 0.1±0.001
0 to 0.8±0.008
0 to 1.7±0.017
0 to 4.7±0.047
0 to 10.6±0.106
0 to 18.8±0.188: 0-10 V				 (special specifications: 0-5 V/1-5 V)• Cable length• Accuracy: 4-20 mA (load resistance: less than				500Ω)• Dedicated cable

ModelBS04SC
BS06
BS06
BS10BS15
BS20Converter

Flow velocity ≥ 1m/s
Flow rate
Accuracy(L/min)(of reading)
0.1 to 0.8±1%
0.8 to 3±1%
1.7 to 8±1%
4.7 to 20±1%
10.6 to 50±1%18.8 to 80±1%

Open collector output		: Load rating: Within 30 V DC, 20 mA• Frequency pulse output : Pulse rate up to 1000 Hz at full scale,				 duty ratio 1 : 1• Totalizing pulse output : Output flow rate unit pulse
Can be set per pulse by combining either of the following
multipliers and units		

:Multiplier			: ×0.1, ×1, ×10, ×100

Unit			: mL, L, m3• Fault output			: Output when converter or detector is					in error
NO or NC is selectable, 0 to 1000 Hz3) Alarm output
Open collector (2 points) :Load rating			: Within 30 V DC, 20 mA

Instantaneous flow rate alarm (max. /min.) and integrated flowrate (A/B) can be used in combination, NO or NC is selectable.
• Display: 16-characters, 2-lines LCD with backlight• Terminal table: Plug-type screw fastening terminal × 3		 (detachable plug-in type)* Note: Accuracy statement is based on water calibration• Pressure loss

• Setting: Panel switch × 4

Pressure loss for water (kPa) = C × Q2• Communication: RS485 communication (Modbus protocol)• Parameter setting: Panel switch or communication• Display content: Instantaneous flow rate, integrated flowwhere C: Factor (Refer to Table 4.)
Q: Flow rate (L/min)
Table 4. Pressure loss factor
ModelBS04SC
BS04
BS06
BS10
BS15
BS202C
3.04
3.04
0.537
0.06250.01200.00377

TOKYO KEISO CO., LTD.		 rate, status		 Alarm: Orange LED• Time constant: 0.5 to 25 seconds• Low cut-off: 0 to 25% F.S.

• Linearization: Automatic adjustment by kinematic velocity		 setting. A manual linearizer can be added		 (up to 20 points, polyline approximation		method).

TG-F2038-E02

BS□□/SFC4000-EV Single-use ultrasonic flowmeter for liquids• Power supply/consumption: 24 V DC ±10%
• Current consumption : 110 mA max. (when LCD backlight is on),		 approx. 200 mA at power-on• Ambient temperature : 0 to 50°C
• Ambient humidity: 30 to 80% RH (no condensation)• Installation method: Panel• Enclosure classification: IP20 (indoor use)
• Material: ABS (black)• Mass: Approx. 200 g：EMC：EN61326-1, EN61326-2-3		 RoHS (2011/65/EU)• Standards

Model code
SFC4000 – EV –□0123

Instantaneous flowrate output

Description
4 –20 mA
0 –10 V
0 –5 V
1–5 V

DIMENSIONSDetector
BS04SC, BS04, BS06
φ10.9
φ9.5
φ6.35

12φ24φ1590

45

φ15

φ273/8" hose barb

80±1
142

4160

31.9

3IN

OUT

567The flow direction is indicatedat the base of the hose barb.

Materials of flow detector
No.

Parts

1234
5
67BodySensor cap
BNC connectorConnector mold
CableConnector cap
MMCX connector

TG-F2038-E02

MaterialPUSPSU
Nickel plating
PVC
PVC coating
PPGold platng

TOKYO KEISO CO., LTD.

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BS□□/SFC4000-EV Single-use ultrasonic flowmeter for liquids

DIMENSIONS
Detector
BS10, BS15, BS20

The cable connector and main-bodyunit connection are color-coded:"red" for upper flow and "black" forlower flow.

Model
BS10
BS15
BS20

Meter size
10 mm
15 mm
20 mm

Connecting
tube size(Innerdiameter)
1/2"
3/4"
1"

Size (mm)
D

d1d2

A

B

LCEFG

14.5
21.7
27.9

12.7
19.1
25.4

9.5
14.7
20.3

110±1
165±2
220±2

176
234294194252
312506881100136
162

19.3
2025323232

CAUTIONS ON INSTALLATION

Materials of flow detector
No.

Parts

1234567

BodySensor cap
BNC connector
Connector mold
CableConnector cap
MMCX connector

MaterialPUS
PSU
Nickel plating
PVC
PVC coating
PPGold platng• To ensure accurate, stable measurement, do not bend theconnecting tube during installation to avoid stress from the piping.
• Install the instrument in a place where no bubbles are contained inthe tubing.
• Keep the measuring tube filled with liquid. Although the instrument
can be installed with horizontal, vertical, or slanted tubing, it isrecommended to select a position for easy self-draining.
• Install a control valve downstream of the instrument, if necessary.
• Install the flow detector and converter away from noise sources
such as power relays and solenoid valves.
• Lay the signal cable away from power cables of high voltage orcurrent.

4

TOKYO KEISO CO., LTD.

TG-F2038-E02

BS□□/SFC4000-EV Single-use ultrasonic flowmeter for liquids

DIMENSIONS
Converter
SFC4000-EV
(112)
96

690

ULTRASONIC FLOWMETER48

SFC4000ENTER

SHIFTMENUZEROALARM
HI/LO
ERROR

Panel thickness : 0.8 to 5 mm

Upper left: CONNECTOR 2TERMINAL ARRANGEMENT1+2–345
AL1 COM AL2CONNECTOR 1SOURCE
24 V DC
12+24V 0V

3FG

Terminal
No.
12345

DETECTOR BNC CONN.
IN
OUT

CONNECTOR 2
PULSE OUT ALARM OUT

CONNECTOR 3

FLOW OUT RESET IN
4+5–

6+7–

RS-485
1+2–

Terminal name
PULSE OUT (+)
PULSE OUT (–)
ALARM1 OUT (AL1)
ALARM1 OUT (COM)
ALARM2 OUT (AL2)

Description
Pulse output
Alarm output

Upper right: DETECTOR BNC CONN.
3
SG

Panel cutout

TerminalINColor
Red

OUT

Black

Polarity
Description
Inflow (upstream)
Sensor signal input
Outflow(downstream)

Lower left: CONNECTOR 1

Min.7045 +0.6-0-0
92 +0.8

Terminal
No.
1234567

Terminal name
SOURCE DC24V (+24V)
SOURCE DC24V (0V)
SOURCE DC24V (FG)FLOW OUT (+)
FLOW OUT (–)
RESET IN (+)
RESET IN (–)

Description
Power supply
24 V DC ±10%
Grounding
Flow rate output
Totalization reset input

Lower right: CONNECTOR 3
Min.120

TerminalNo.
123

Terminal name
RS-485 (+)
RS-485 (–)
RS-485 (SG)

Description
RS-485 communication* Specification is subject to change without notice.

Head Office : Shiba Toho Building, 1 – 7 – 24 Shibakoen, Minato-ku, Tokyo 105 – 8558
Tel : +81-3 – 3431 – 1625 (KEY) ; Fax : +81-3 – 3433 – 4922
e-mail : overseas.sales@tokyokeiso.co.jp ; URL : https://www.tokyokeiso.co.jp
TG-F2038-E02

TOKYO KEISO CO., LTD.

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