I~l~rofl;ct

lily 11.

H.
~l,R.
R.
~.

l,[.
A.
E.
A.

F,AS[LOt(GH[J.SOHOBER
P~OKOP

219-2
21L~),.-2E
218-3
218-22)5-3B

Those present ~et on April 28, 1978 to discuss results of Lhe ~ d~y adl]
studies carried ~t zt I.R.D.C. 1he ~$1~ ~ Of s~t~ ~ ~ usln9plet~ in ~y. ~ up-to-da~ s~tus s~ of 111 s~4~ ~s su~11~
by J. E. Long ~ ts at~ch~ ~ ~se atN~s. A ~le~ ~rt f~
I.R.D.C., ~)~1ng hts~t~lo91~ai ~ h d~ b ~ or ~ly for ~rat s~tes a~ later tn t~ fall foe ~ ~y e~r~tS.
After a very brief discuss|on of the most iI~lmt rtsults fr1~ th~ antml
studies, N. T. ~se, J. E. Long, R. A. ~l~n l~ R. E. ~lg~ t~t
FC-95, ~-~22 a~ FC-1U s~ld ~ ~as ~xlc ~!~of toxicity ~s left u~efin~.

R. E. 0bet inquired as’to the tyl~ and ~nt$ of Im!~rttles present in
FC-95. FN-3422 an~ FC-143. ~ t~dtles. If sufflcl~tly ~xlc, c~ld
cause ~er~s c~cluslon f~ t~ enl~l s~tes. ~rt~ ~ dlKusslon,
tt w, ~tnted ~t ~t FC-95 ~s ~n tdentlft~ In ~ b1~ of rats ~lch~re f~ F~22. T~ ~estton a~se as ~t~r ~-~t~t ~ an t~~rtty in FM-~22. The ans~r~s ~t kn~. L A. ~ q~ ~ ~pply~ c~lttee ~th al1 available l~fo~ti~ ~ t~dtf, ~t I~ K-9~,~-~22 a~ FC-143.

~CE.:IIEO

3MA10067059

CONFIDENTIAL - SUBJECT TO A PROTECTIVE ORDER ENTERED IN HENNEPIN COUNTYDISTRICT COURT, NO. 27-CV-10-28862

1174.0001

3M MN00053074

R. E. Ober raised the question as tO wh|chFC-g5 ~u|d ca~e g~eat~st worker exposu~.
relstod to ~ese c~s, ~ deftnt~

Because or the many productsHygiene s~uld s~ ~ t~ tn l~ttf~H
ex~sure ~la~ ~ ~M22 a~

A discussion them ~k place on t~vtng the cap~bllit~y ~ ~tll~tq for
R. A, Nelson and J. E. L~ felt ~t fC-9S ~ld ~ I~tf]~ as ~t~present ~fo~ p~tng vt~ t~ s~l," sl~e tt I~ ~slble ~t m l~~llte of FC-95 might ~ res~slb)e for ~xlc ~f~ ~ ~att~lf. R. E. ~r ~ such states ms su~]~]. (t ~ mg~ ~ta~lytlcal ~rk on FC-95 (n t~ se~ ~ )i~r of ~ ~1~ ~as rapidly as ~ssible.
]t was questioned why FC-95. F1~.3422 and FC-143 were cho~m for thestudies,
FC.143 and FC-95 have be~ fouad In tee employ.
FN-3422 isInter~late which goes into a variety of prOduCt.~.. R. E. ~ ~S~ ~te t~ year study on ~-3~2Z ~uld gtve lnf~tion ~ ~ ~ff~ts ofand ~ss]ble m~lltes,
it was og~ ~ ~ls s~t~ ~ldg~v~a further consecration.

R.A, Nelson stated that ].R.D.C. ts now savln9 monkeys for tee t~o year antml
sLudies. If we are to use these animls, we m~st p~rc~ fJw~ ~ow at a costof $61,280 and ~y $78~ ~r ~nth ~ mtn~tn ~, i.R.D.C. ~nts an ~ns~rby ~y ], 1978, If ~ ~ not purc~se aM ~tn~tn ~ ~ys, ~ my~ available later for t~ anlml states. ~r, ~l~e It ~l ~t ~tbe~ d~id~ wlth cer~Int] t~t ~ke~ wtll M u~ In ~ ~ ~r s~dies,t~se p~s~t rec~ ~t purc~t~ t~ ~ ~t th]~ t]~.

3MA10067060

CONFIDENTIAL - SUBJECT TO A PROTECTIVE ORDER ENTERED IN HENNEPIN COUNTYDISTRICT COURT, NO. 27-CV-10-28862

1174.0002

3M MN00053075

-3-

Those present again considered the aunt}able toxicity data on FC-95, FH-34ZZ
and F1~-~43,
It ~as ~tnt~ out that ~}e rats fed FC-]43 at the 1~ ~~evel ~d ~ut 50 p~ FC-]43 tn their bl~ and that one Ch~lite ~rterrats had liver d~scoloratlon ~f~les ~d ~ne).
It ~s concl~ed that thellver discoloration tn rats associated wJth a bl~ level of ~ p~ suggests
a ~ssfb]e h~n ~alth prob]~ for l~ivJduals w~ ~ve this ~eve] (or a~ve)
In their b]o~ for long ~rl~s of tt~. T~se present also co~]ud~ thefoisting:As concluded previously by the full con~ittee, available data in man indicatesthat no substantial risk exists under the Toxic Substances Control Act.
However, those present urgent]y rec(x~ended that al! reasonable steps be
taken i~edtately to reduce exposure of e~loyees to these COBpoundL

It ~as also agreed that:R. E. O~r will ~ake pPoposals on ~etabolic studies and ~ke apresentation to tt~ c~Ittee on such studies.
R. A. Prokop and J. E. Long will ~ke certain that Rtker has all previous
analytical and toxicological data involving fluor~chmlcals in blood.
A protocol should be written for sa~pltng of employees blood.

It will be necessary to have a method for analyzing FC-95, 1~-342Z andFC-143 in the food used in antra| studies.

Su~! tied byR.

A. Prokop

RAP:drattachcent

3MA100~7061

CONFIDENTIAL - SUBJECT TO A PROTECTIVE ORDER ENTERED IN HENNEPIN COUNTYDISTRICT COURT, NO. 27-CV-10-28862

1174.0003

3M MN00053076