Premium Bisulfite kit
C02030030
Flyleaf
Date of compilation: 2020-11-05

Bill of materials
Name of substance

Identifier

Numberof pieces

Conversion reagent

5

Binding buffer1wash buffer

1

Desulphonation buffer

1

Elution buffer

1

United States

DIAGENODE 000532 KIT-08

Classificationacc. to GHS

PictogramsPage
2 – 10

Acute Tox. 4 /H302
Skin Irrit. 2 / H315
Eye Irrit. 2 / H319

11 – 20

21 – 28
Skin Corr. 1B /H314
Eye Dam. 1 / H318
Carc. 1A / H350
STOT SE 3 / H336
Flam. Liq. 2 / H225

29 – 42

43 – 50

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 1: Identification
1.1

product identifier
Conversion reagent

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

United States

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)

2.3- signal word

not required- pictograms

not required

other hazards
there is no additional information.

hazards not otherwise classified
may be harmful if swallowed (GHS category 5: acutely toxic - oral).
may be harmful in contact with skin (GHS category 5: acutely toxic - dermal).
may be harmful if inhaled (GHS category 5: acutely toxic - inhalation).
harmful to aquatic life (GHS category 3: aquatic toxicity - acute).

results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

United States: en

page: 1 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixture

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

variousodorcharacteristic

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

acute toxicity
shall not be classified as acutely toxic.
GHS of the United Nations, annex 4: may be harmful if swallowed, in contact with skin or if inhaled.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
harmful to aquatic life.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

DGR

Dangerous Goods Regulations (see IATA/DGR)

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and ToxicvPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Conversion reagent
version number: GHS 1.0

date of compilation: 2020-11-05

transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 9 / 9Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 1: Identification
1.1

product identifier
Binding buffer

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

United States

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
sectionhazard class

categoryhazard class and category

hazard statement

A.1O

acute toxicity (oral)

4

Acute Tox. 4

H302

A.2

skin corrosion/irritation

2

Skin Irrit. 2

H315

A.3

serious eye damage/eye irritation

2

Eye Irrit. 2

H319

for full text of abbreviations: see SECTION 16.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)- signal word

warning- pictograms
GHS07- hazard statements
H302
H315
H319

United States: enharmful if swallowed.
causes skin irritation.
causes serious eye irritation.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05- precautionary statements
P270
P280
P301+P312
P302+P352
P305+P351+P338
P321
P330
P332+P313
P337+P313
P362
P501

do not eat, drink or smoke when using this product.
wear protective gloves.
if swallowed: Call a poison center/doctor if you feel unwell.
if on skin: Wash with plenty of water.
if in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.
specific treatment (see on this label).
rinse mouth.
if skin irritation occurs: Get medical advice/attention.
if eye irritation persists: Get medical advice/attention.
take off contaminated clothing and wash it before reuse.
dispose of contents/container to industrial combustion plant.

- hazardous ingredients for labelling
2.3

Guanidinium chloride

other hazards
hazards not otherwise classified
may be harmful in contact with skin (GHS category 5: acutely toxic - dermal).
harmful to aquatic life (GHS category 3: aquatic toxicity - acute).

results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixturename of substanceidentifier

wt%classification acc. to GHS

Guanidinium chloride

CAS No50-01-1≤ 60

Acute Tox. 4 / H302
Acute Tox. 4 / H332
Skin Irrit. 2 / H315
Eye Irrit. 2 / H319

pictograms

for full text of abbreviations: see SECTION 16.

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. in case of respiratory
tract irritation, consult a physician. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

United States: en

page: 2 / 10

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

United States: en

page: 3 / 10

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

relevant DNELs of components of the mixture

8.2

name of substance

CAS Noendpoint

thresholdlevel

protection goal,route of exposure

used inexposure time

Guanidinium chloride

50-01-1

DNEL

3.5 mg/m³

human, inhalatory

worker (industry)

chronic - systemic
effects

Guanidinium chloride

50-01-1

DNEL

10.5 mg/m³

human, inhalatory

worker (industry)

acute - systemic effects

Guanidinium chloride

50-01-1DNEL

1 mg/kg bw/
dayhuman, dermal

worker (industry)

chronic - systemic
effects

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.
United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodorcharacteristic

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

9.2

date of compilation: 2020-11-05

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
see below "Conditions to avoid".

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidizers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
acute toxicity
harmful if swallowed.
GHS of the United Nations, annex 4: may be harmful in contact with skin.

- acute toxicity estimate (ATE)

1,113 mg/kg

oral

acute toxicity estimate (ATE) of components of the mixturename of substance

CAS Noexposure routeATE

guanidinium chloride

50-01-1

oral

556.5 mg/kg

guanidinium chloride

50-01-1

inhalation: dust/mist

3.181 mg/l/4h

skin corrosion/irritation
causes skin irritation.

serious eye damage/eye irritation
causes serious eye irritation.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
harmful to aquatic life.

aquatic toxicity (acute) of components of the mixture

12.2

name of substance

CAS Noendpoint

value

species

exposuretime

guanidinium chloride

50-01-1

LC50

1,758 mg/l

fish

48 h

aquatic invertebrates

48 h

algae

72 h

guanidinium chloride

50-01-1

EC5070.2 mg/

guanidinium chloride

50-01-1

ErC50

33.5 mg/llpersistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

category

ratingdescription

Chronic/

none

Health2

temporary or minor injury may occur

Flammability

1material that must be preheated before ignition can occur

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability

1material that must be preheated before ignition can occur

Health2

material that, under emergency conditions, can cause temporary incapacitation or residual injury

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Acute Tox.

Acute toxicity

ATE

Acute Toxicity Estimate

CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

DGR

Dangerous Goods Regulations (see IATA/DGR)

DNELDerived No-Effect Level

EC50

Effective Concentration 50 %. The EC50 corresponds to the concentration of a tested substance causing 50 %changes in response (e.g. on growth) during a specified time interval

ErC50≡ EC50: in this method, that concentration of test substance which results in a 50 % reduction in either growth(EbC50) or growth rate (ErC50) relative to the control

Eye Dam.

Seriously damaging to the eye

Eye Irrit.

Irritant to the eye

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

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Binding buffer
version number: GHS 1.0

date of compilation: 2020-11-05

abbr.

descriptions of used abbreviations

IMDG

International Maritime Dangerous Goods Code

LC50

Lethal Concentration 50%: the LC50 corresponds to the concentration of a tested substance causing 50 % lethality during a specified time interval

MARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

RTECS

Registry of Toxic Effects of Chemical Substances (database of NIOSH with toxicological information)

Skin Corr.

Corrosive to skin

Skin Irrit.

Irritant to skinvPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

list of relevant phrases (code and full text as stated in chapter 2 and 3)
code

text

H302

Harmful if swallowed.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H332

Harmful if inhaled.

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

wash buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 1: Identification
1.1

product identifier
wash buffer

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

United States

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

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wash buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

wash buffer
version number: GHS 1.0

6.3

date of compilation: 2020-11-05

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

wash buffer
version number: GHS 1.0

date of compilation: 2020-11-05

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodorcharacteristic

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
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this information is not available
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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

wash buffer
version number: GHS 1.0

9.2

date of compilation: 2020-11-05

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

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wash buffer
version number: GHS 1.0

date of compilation: 2020-11-05

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

wash buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

wash buffer
version number: GHS 1.0

date of compilation: 2020-11-05

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

DGR

Dangerous Goods Regulations (see IATA/DGR)

IATAInternational Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and ToxicvPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 1: Identification
1.1

product identifier
Desulphonation buffer

trade name
1.2

1.3

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

for research use only, not for use in diagnostic ortherapeutic procedures.

uses advised against

do not use for squirting or spraying. do not use for
products which come into direct contact with theskin.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

United States

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
sectionhazard class

categoryhazard class and category

hazard statement

A.2

skin corrosion/irritation

1B

Skin Corr. 1B

H314

A.3

serious eye damage/eye irritation

1

Eye Dam. 1

H318

A.6

carcinogenicity

1A

Carc. 1A

H350

A.8D

specific target organ toxicity - single exposure (narcotic effects, drowsiness)

3

STOT SE 3

H336

B.6

flammable liquid

2Flam. Liq. 2

H225

for full text of abbreviations: see SECTION 16.

the most important adverse physicochemical, human health and environmental effects
skin corrosion produces an irreversible damage to the skin; namely, visible necrosis through the epidermis and into thedermis. the product is combustible and can be ignited by potential ignition sources.

2.2

label elements

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

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version number: GHS 1.0

date of compilation: 2020-11-05

labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)- signal word

danger- pictograms
GHS02, GHS05, GHS07,
GHS08- hazard statements
H225
H314
H336
H350

highly flammable liquid and vapor.
causes severe skin burns and eye damage.
may cause drowsiness or dizziness.
may cause cancer.

- precautionary statements
P202
P210
P240
P241
P242
P243
P260
P271
P280
P301+P330+P331
P303+P361+P353
P304+P340
P305+P351+P338
P310
P321
P363
P370+P378
P403+P233
P403+P235
P405
P501

do not handle until all safety precautions have been read and understood.
keep away from heat/sparks/open flames/hot surfaces. No smoking.
ground/bond container and receiving equipment.
use explosion-proof electrical/ventilating/lighting equipment.
use only non-sparking tools.
take precautionary measures against static discharge.
do not breathe dusts or mists.
use only outdoors or in a well-ventilated area.
wear protective gloves/eye protection/face protection.
if swallowed: Rinse mouth. Do NOT induce vomiting.
if on skin (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower.
if inhaled: Remove person to fresh air and keep comfortable for breathing.
if in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.
immediately call a poison center/doctor.
specific treatment (see on this label).
wash contaminated clothing before reuse.
in case of fire: Use sand, carbon dioxide or powder extinguisher to extinguish.
store in a well-ventilated place. Keep container tightly closed.
store in a well-ventilated place. Keep cool.
store locked up.
dispose of contents/container to industrial combustion plant.

- hazardous ingredients for labelling
2.3

Ethanol, Propan-2-ol, Sodium hydroxide

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixtures

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description of the mixture

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

name of substanceidentifier

wt%classification acc. to GHS

Ethanol

CAS No64-17-530

Carc. 1A / H350
Flam. Liq. 2 / H225

Propan-2-ol

CAS No67-63-030

Eye Irrit. 2 / H319
STOT SE 3 / H336
Flam. Liq. 2 / H225

Sodium hydroxide

CAS No1310-73-2

2.5

Skin Corr. 1A / H314
Eye Dam. 1 / H318

pictograms

for full text of abbreviations: see SECTION 16.

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. in case of respiratory
tract irritation, consult a physician. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
narcotic effects.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
in case of insufficient ventilation and/or in use, may form flammable/explosive vapor-air mixture. solvent vapors are heavier
than air and may spread along floors. places which are not ventilated, e.g. unventilated below ground level areas such as
trenches, conduits and shafts, are particularly prone to the presence of flammable substances or mixtures.

hazardous combustion products
carbon monoxide (CO), carbon dioxide (CO2)

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Desulphonation buffer
version number: GHS 1.0

5.3

date of compilation: 2020-11-05

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. avoidance of ignition sources. keep away from sources of ignition - No smoking. take precautionary measures against static discharge. use only in well-ventilated areas. due to danger of explosion, prevent leakage of vapours into cellars, flues and ditches. ground/bond container and receiving equipment. use explosion-proof electrical/ventilating/lighting/equipment. use only non-sparking tools.

- specific notes/details
places which are not ventilated, e.g. unventilated below ground level areas such as trenches, conduits and shafts, are particularly prone to the presence of flammable substances or mixtures. vapors are heavier than air, spread along floors and form
explosive mixtures with air. vapors may form explosive mixtures with air.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities

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Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

managing of associated risks- explosive atmospheres
keep container tightly closed and in a well-ventilated place. use local and general ventilation. keep cool. protect from sunlight.

- flammability hazards
keep away from sources of ignition - No smoking. keep away from heat, hot surfaces, sparks, open flames and other ignition
sources. No smoking. take precautionary measures against static discharge. protect from sunlight.

control of the effects
protect against external exposure, such as
frost- ventilation requirements
use local and general ventilation. ground/bond container and receiving equipment.

- packaging compatibilities
only packagings which are approved (e.g. acc. to the Dangerous Goods Regulations) may be used.

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierUSsodium hydroxide

1310-73-2

REL

2

NIOSH
REL

US

sodium hydroxide

1310-73-2

TLV®

2

ACGIH®
2019US

sodium hydroxide

1310-73-2

PEL

US

sodium hydroxide(caustic soda)

1310-73-2

PEL
(CA)

US

ethanol

64-17-5TLV®

USethyl alcohol

64-17-5REL

1,000(10 h)

1,900(10 h)

NIOSH
REL

US

ethyl alcohol (ethanol)

64-17-5

PEL
(CA)

1,000

1,900

Cal/
OSHA
PEL

US

ethyl alcohol (ethanol)

64-17-5

PEL

1,000

1,900

29 CFR
1910.1000US2-propanol

67-63-0

TLV®

200

US

isopropyl alcohol

67-63-0

PEL
(CA)

400

United States: en

TWA
[ppm]

TWA
[mg/m³]

STEL
[ppm]

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion2

29 CFR
1910.100
0
2

1,000

500

Cal/
OSHA
PEL
ACGIH®
2019

400
980

sourceACGIH®
2019
1,225

Cal/
OSHA
PEL

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS Noidentifier

TWA
[ppm]

TWA
[mg/m³]

STEL
[ppm]

US

isopropyl alcohol

67-63-0

REL

400(10 h)

980(10 h)

500

USisopropyl alcohol

67-63-0

PEL

400

980

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion
1,225

sourceNIOSHREL
29 CFR
1910.1000notation
Ceiling-C
STEL
TWA

ceiling value is a limit value above which exposure should not occur
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified

biological limit values
country

name of agent

parameterUSisopropanolacetonenotation

identifiervaluesourceBEI®

40 mg/l

ACGIH® 2019relevant DNELs of components of the mixturename of substance

CAS Noendpoint

thresholdlevel

protection goal,route of exposure

used inexposure time

Propan-2-ol

67-63-0

DNEL

500 mg/m³

human, inhalatory

worker (industry)

chronic - systemic
effects

Propan-2-ol

67-63-0

DNEL

888 mg/kg bw/
dayhuman, dermal

worker (industry)

chronic - systemic
effects

Sodium hydroxide

1310-73-2

DNEL

1 mg/m³

human, inhalatory

worker (industry)

chronic - local effects

relevant PNECs of components of the mixture

8.2

name of substance

CAS Noendpoint

thresholdlevel

organism

environmental
compartment

exposure time

Propan-2-ol

67-63-0

PNEC

140.9 mg/l

aquatic organisms

freshwater

short-term (single
instance)

Propan-2-ol

67-63-0

PNEC

140.9 mg/l

aquatic organisms

marine water

short-term (single
instance)

Propan-2-ol

67-63-0

PNEC

2,251 mg/l

aquatic organisms

sewage treatment
plant (STP)

short-term (single
instance)

Propan-2-ol

67-63-0

PNEC

552 mg/kg

aquatic organisms

freshwater sediment

short-term (single
instance)

Propan-2-ol

67-63-0

PNEC

552 mg/kg

aquatic organisms

marine sediment

short-term (single
instance)

Propan-2-ol

67-63-0

PNEC

28 mg/kg

terrestrial organisms

soil

short-term (single
instance)

exposure controls
appropriate engineering controls
general ventilation.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodorcharacteristic

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

solubility(ies)date of compilation: 2020-11-05

not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials". the mixture contains reactive substance(s). risk of ignition.

if heated:risk of ignition

10.2

chemical stability
see below "Conditions to avoid".

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

hints to prevent fire or explosion
use explosion-proof electrical/ventilating/lighting/equipment. use only non-sparking tools. take precautionary measuresagainst static discharge.

10.5

incompatible materials
oxidizers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
acute toxicity
shall not be classified as acutely toxic.
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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

skin corrosion/irritation
causes severe skin burns and eye damage.

serious eye damage/eye irritation
causes serious eye damage.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
may cause cancer.

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
name of substance

CAS Noclassification

propan-2-ol

67-63-03ethanol

64-17-5

1

numberlegend1
3

Carcinogenic to humans
Not classifiable as to carcinogenicity in humans

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
may cause drowsiness or dizziness.

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 13: Disposal considerations
13.1

waste treatment methods
waste treatment-relevant information
solvent reclamation/regeneration.

sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
only packagings which are approved (e.g. acc. to DOT) may be used. completely emptied packages can be recycled. handle
contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN number

2924

14.2

UN proper shipping nameFlammable liquid, corrosive, n.o.s.

technical name (hazardous ingredients)

propan-2-ol, sodium hydroxide

14.3transport hazard class(es)class

3 (flammable liquids)

subsidiary risk(s)8 (corrosive effects)

14.4

packing group

II (substance presenting medium danger)

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
index number

2924

proper shipping nameFlammable liquid, corrosive, n.o.s.

- particulars in the shipper's declaration

UN2924, Flammable liquid, corrosive, n.o.s., (contains: propan-2-ol, sodium hydroxide), 3 (8), II

class

3

subsidiary risk(s)8packing groupII

danger label(s)3+8special provisions (SP)IB2, T11, TP2, TP27

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

ERG No132

International Maritime Dangerous Goods Code (IMDG)
UN number

2924

proper shipping name

FLAMMABLE LIQUID, CORROSIVE, N.O.S.

class

3

subsidiary risk(s)8marine pollutant-

packing groupII

danger label(s)3+8special provisions (SP)274

excepted quantities (EQ)

E2

limited quantities (LQ)

1L

EmS

F-E, S-C

stowage category

B

International Civil Aviation Organization (ICAO-IATA/DGR)
UN number

2924

proper shipping nameFlammable liquid, corrosive, n.o.s.

class

3

subsidiary risk(s)8packing groupII

danger label(s)3+8special provisions (SP)A3

excepted quantities (EQ)

E2

limited quantities (LQ)

0,5 L

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic*

chronic (long-term) health effects may result from repeated overexposure

Health3major injury likely unless prompt action is taken and medical treatment is given

Flammability

3material that can be ignited under almost all ambient temperature conditions

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

category

ratingdescription

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability

3material that can be ignited under almost all ambient temperature conditions

Health3

material that, under emergency conditions, can cause serious or permanent injury

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

29 CFR 1910.1000

29 CFR 1910.1000, Tables Z-1, Z-2, Z-3 - Occupational Safety and Health Standards: Toxic and Hazardous Substances (permissible exposure limits)

49 CFR US DOT

49 CFR U.S. Department of Transportation

ACGIH® 2019

From ACGIH®, 2019 TLVs® and BEIs® Book. Copyright 2019. Reprinted with permission. Information on theproper use of the TLVs® and BEIs®: http://www.acgih.org/tlv-bei-guidelines/policies-procedures-presentations/tlv-bei-position-statement

Cal/OSHA PEL

California Division of Occupational Safety and Health (Cal/OSHA): Permissible Exposure Limits (PELs)

Carc.

Carcinogenicity

CAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

DGR

Dangerous Goods Regulations (see IATA/DGR)

DNELDerived No-Effect Level

DOT

Department of Transportation (USA)EmSEmergency Schedule

ERG NoEmergency Response Guidebook - Number

Eye Dam.

Seriously damaging to the eye

Eye Irrit.

Irritant to the eye

Flam. Liq.

Flammable liquid

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

abbr.

descriptions of used abbreviations

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NIOSH REL

National Institute for Occupational Safety and Health (NIOSH): Recommended Exposure Limits (RELs)

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

PEL

Permissible exposure limit

PNEC

Predicted No-Effect Concentrationppm

Parts per million

RTECS

Registry of Toxic Effects of Chemical Substances (database of NIOSH with toxicological information)

Skin Corr.

Corrosive to skin

Skin Irrit.

Irritant to skin

STEL

Short-term exposure limit

STOT SESpecific target organ toxicity - single exposure

TLV®

Threshold Limit Values

TWA

Time-weighted averagevPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

list of relevant phrases (code and full text as stated in chapter 2 and 3)
code

text

H225

Highly flammable liquid and vapor.

H314

Causes severe skin burns and eye damage.

H318

Causes serious eye damage.

H319

Causes serious eye irritation.

H336

May cause drowsiness or dizziness.

H350

May cause cancer.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Desulphonation buffer
version number: GHS 1.0

date of compilation: 2020-11-05

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Elution buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 1: Identification
1.1

product identifier
Elution buffer

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

United States

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Elution buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

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Elution buffer
version number: GHS 1.0

6.3

date of compilation: 2020-11-05

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Elution buffer
version number: GHS 1.0

date of compilation: 2020-11-05

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodorcharacteristic

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Elution buffer
version number: GHS 1.0

9.2

date of compilation: 2020-11-05

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

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Elution buffer
version number: GHS 1.0

date of compilation: 2020-11-05

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

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Elution buffer
version number: GHS 1.0

date of compilation: 2020-11-05

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

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version number: GHS 1.0

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category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

DGR

Dangerous Goods Regulations (see IATA/DGR)

IATAInternational Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and ToxicvPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

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