MagMeDIP qPCR Kit
C02010020
C02010021
Flyleaf
Date of compilation: 2020-04-07

Bill of materials
Name of substance

Identifier

Numberof piecesClassificationacc. to GHS

Pictograms

Page

Magbeads1

3 – 10

ChIP-seq grade water2

11 – 185x MagBuffer A

1

MagBuffer B

1

29 – 36

MagBuffer C

1

37 – 44

5-mC monoclonal antibody 33D3

1

45 – 52

Methylated spike-in control

1

53 – 60

Unmethylated spike-in
control

1

61 – 68

MagWash buffer-1

1

MagWash buffer-2

1

79 – 86

DNA Isolation Buffer
(DIB)

1

87 – 94

proteinase K

2

Primer pair for meDNA
spike-in ctrl

1

104 – 111

Primer pair for unDNA
spike-in ctrl

1

112 – 119

TSH2B primer pair1

120 – 127

ChIP-seq grade GAPDHTSS primer pair1

128 – 135GenDNA Digestion buffer

1

136 – 143

GenDNA precipitant1

144 – 151

United States

DIAGENODE 000297 KIT-08

Eye Dam. 1 / H318

Eye Irrit. 2 / H319

Resp. Sens. 1 /H334

19 – 28

69 – 78

95 – 103

MagMeDIP qPCR Kit
C02010020
C02010021
Flyleaf
Date of compilation: 2020-04-07

Name of substance

Identifier

Numberof piecesClassificationacc. to GHS

Pictograms

Page

GenDNA TE

1

152 – 159

GenDNA RNAse (DNAsefree)1

160 – 168

United States

DIAGENODE 000297 KIT-08

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
Magbeads

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquid (suspension)

color

brown

odor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Magbeads
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

SECTION 1: Identification
1.1

1.2

product identifier
identification of the substance

ChIP-seq grade water

CAS number

7732-18-5

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this substance does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
according to the results of its assessment, this substance is not a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substancesname of substance

ChIP-seq grade water

identifiers
CAS No7732-18-5

molecular formula

H2O

molar mass

18.02 g/mol

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, alcohol resistant foam, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

6.3

date of compilation: 2019-12-23

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

0 °C

initial boiling point and boiling range

100 °C

flash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)- water solubility

United States: en

miscible in any proportion

page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

partition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this substance does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
waste treatment-relevant information
recycling/reclamation of other inorganic materials.

sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade waterversion number: GHS 1.0

date of compilation: 2019-12-23

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
no Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources BoardCAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
5x MagBuffer A

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
sectionhazard class

categoryhazard class and category

hazard statement

A.3

serious eye damage/eye irritation

1

Eye Dam. 1

H318

for full text of abbreviations: see SECTION 16.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)- signal word

danger- pictograms
GHS05- hazard statements
H318

causes serious eye damage.

- precautionary statements
P280
P305+P351+P338
P310
United States: enwear eye protection/face protection.
if in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.
immediately call a poison center/doctor.
page: 1 / 10

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07- hazardous ingredients for labelling
2.3

Triton X-100

other hazards
hazards not otherwise classified
toxic to aquatic life with long lasting effects (GHS category 2: aquatic toxicity - acute and/or chronic).

results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixturename of substanceidentifier

wt%classification acc. to GHS

Triton X-100

CAS No9002-93-1≤ 10

Acute Tox. 4 / H302
Skin Irrit. 2 / H315
Eye Dam. 1 / H318

pictograms

for full text of abbreviations: see SECTION 16.

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx), carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it. if substance hasentered a water course or sewer, inform the responsible authority.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such asfrost- packaging compatibilities
only packagings which are approved (e.g. acc. to the Dangerous Goods Regulations) may be used.

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
see below "Conditions to avoid".

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidizers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
causes serious eye damage.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
toxic to aquatic life with long lasting effects.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
only packagings which are approved (e.g. acc. to DOT) may be used. completely emptied packages can be recycled. handle
contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN number

3082

14.2

UN proper shipping name

Environmentally hazardous substance, liquid, n.o.s.

technical name (hazardous ingredients)

Triton X-100

14.3

transport hazard class(es)class

9 (environmentally hazardous)

14.4

packing group

III (substance presenting low danger)

14.5

environmental hazards

hazardous to the aquatic environment

environmentally hazardous substance (aquatic
environment)

Triton X-100

14.6

special precautions for user
there is no additional information.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

14.7

date of compilation: 2020-04-07

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
index number

3082

proper shipping name

Environmentally hazardous substance, liquid, n.o.s.

- particulars in the shipper's declaration

UN3082, Environmentally hazardous substance, liquid, n.o.s., (contains: Triton X-100), 9, III

class

9

packing groupIII

danger label(s)9, fish and tree

environmental hazards

yes (hazardous to the aquatic environment)

special provisions (SP)8, 146, 173, 335, IB3, T4, TP1, TP29

ERG No171

International Maritime Dangerous Goods Code (IMDG)
UN number

3082

proper shipping name

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, LIQUID, N.O.S.

class

9

marine pollutant

yes (hazardous to the aquatic environment)

packing groupIII

danger label(s)9, fish and tree

special provisions (SP)274, 335, 969

excepted quantities (EQ)

E1

limited quantities (LQ)

5L

EmS

F-A, S-F

stowage category

A

International Civil Aviation Organization (ICAO-IATA/DGR)
UN number

3082

proper shipping name

Environmentally hazardous substance, liquid, n.o.s.

class

9

environmental hazards

yes (hazardous to the aquatic environment)

packing groupIII

danger label(s)9, fish and tree

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

special provisions (SP)A97, A158, A197

excepted quantities (EQ)

E1

limited quantities (LQ)

30 kg

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health3major injury likely unless prompt action is taken and medical treatment is given

Flammability

1material that must be preheated before ignition can occur

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability

1material that must be preheated before ignition can occur

Health3

material that, under emergency conditions, can cause serious or permanent injury

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Acute Tox.

Acute toxicity

Cal ARB

California Air Resources BoardCAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

DGR

Dangerous Goods Regulations (see IATA/DGR)

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5x MagBuffer A
version number: GHS 1.0

date of compilation: 2020-04-07

abbr.

descriptions of used abbreviations

DOT

Department of Transportation (USA)EmSEmergency Schedule

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

ERG NoEmergency Response Guidebook - Number

Eye Dam.

Seriously damaging to the eye

Eye Irrit.

Irritant to the eye

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

RTECS

Registry of Toxic Effects of Chemical Substances (database of NIOSH with toxicological information)

Skin Corr.

Corrosive to skin

Skin Irrit.

Irritant to skin

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

list of relevant phrases (code and full text as stated in chapter 2 and 3)
code

text

H302

Harmful if swallowed.

H315

Causes skin irritation.

H318

Causes serious eye damage.

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 10 / 10

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
MagBuffer B

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixtures

United States: en

description of the mixture

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
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Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer B
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
MagBuffer C

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

light yellow

odor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidizers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DMagBuffer C
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

date of compilation: 2020-01-30

SECTION 1: Identification
1.1

1.2

product identifiertrade name5-mC monoclonal antibody 33D3

product code(s)C15200081

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis product is composed of antibodies in aqueous buffer solution. It contains 0.05% sodium azide as preservative.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

date of compilation: 2020-01-30

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

6.3

date of compilation: 2020-01-30

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

date of compilation: 2020-01-30

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

9.2

date of compilation: 2020-01-30

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

date of compilation: 2020-01-30

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

date of compilation: 2020-01-30

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

5-mC monoclonal antibody 33D3
version number: GHS 1.0

date of compilation: 2020-01-30

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
Methylated spike-in control

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Methylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
Unmethylated spike-in control

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Unmethylated spike-in control
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
MagWash buffer-1

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
sectionhazard class

categoryhazard class and category

hazard statement

A.3

serious eye damage/eye irritation

2

Eye Irrit. 2

H319

for full text of abbreviations: see SECTION 16.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)- signal word

warning- pictograms
GHS07- hazard statements
H319

causes serious eye irritation.

- precautionary statements
P280
P305+P351+P338
P337+P313
United States: enwear eye protection/face protection.
if in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present andeasy to do. Continue rinsing.
if eye irritation persists: Get medical advice/attention.
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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

2.3

date of compilation: 2020-04-07

other hazards
hazards not otherwise classified
harmful to aquatic life with long lasting effects (GHS category 3: aquatic toxicity - acute and/or chronic).

results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixturename of substanceidentifier

wt%classification acc. to GHS

Triton X-100

CAS No9002-93-1≤2

Acute Tox. 4 / H302
Skin Irrit. 2 / H315
Eye Dam. 1 / H318

pictograms

for full text of abbreviations: see SECTION 16.

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
see below "Conditions to avoid".

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
causes serious eye irritation.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

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version number: GHS 1.0

date of compilation: 2020-04-07

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
harmful to aquatic life with long lasting effects.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health2

temporary or minor injury may occur

Flammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-1
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Acute Tox.

Acute toxicity

Cal ARB

California Air Resources BoardCAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

Eye Dam.

Seriously damaging to the eye

Eye Irrit.

Irritant to the eye

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

RTECS

Registry of Toxic Effects of Chemical Substances (database of NIOSH with toxicological information)

Skin Corr.

Corrosive to skin

Skin Irrit.

Irritant to skin

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

list of relevant phrases (code and full text as stated in chapter 2 and 3)

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

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version number: GHS 1.0

date of compilation: 2020-04-07

code

text

H302

Harmful if swallowed.

H315

Causes skin irritation.

H318

Causes serious eye damage.

H319

Causes serious eye irritation.

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 10 / 10

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-2
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
MagWash buffer-2

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-2
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-2
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-2
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

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version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

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version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-2
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

MagWash buffer-2
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

date of compilation: 2020-03-26

SECTION 1: Identification
1.1

product identifier
DNA Isolation Buffer (DIB)

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

date of compilation: 2020-03-26

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

6.3

date of compilation: 2020-03-26

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

date of compilation: 2020-03-26

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

9.2

date of compilation: 2020-03-26

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

date of compilation: 2020-03-26

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

date of compilation: 2020-03-26

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

DNA Isolation Buffer (DIB)
version number: GHS 1.0

date of compilation: 2020-03-26

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

date of compilation: 2020-03-24

SECTION 1: Identification
1.1

product identifierproteinase K

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
sectionhazard class

categoryhazard class and category

hazard statement

A.4R

respiratory sensitization

1

Resp. Sens. 1

H334

for full text of abbreviations: see SECTION 16.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)- signal word

danger- pictograms
GHS08- hazard statements
H334

United States: en

may cause allergy or asthma symptoms or breathing difficulties if inhaled.

page: 1 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

date of compilation: 2020-03-24- precautionary statements
P261
P285
P304+P341
P342+P311
P501

avoid breathing dust/fume/gas/mist/vapors/spray.
in case of inadequate ventilation wear respiratory protection.
if inhaled: If breathing is difficult, remove person to fresh air and keep comfortable for breathing.
if experiencing respiratory symptoms: Call a poison center/doctor.
dispose of contents/container to industrial combustion plant.

- hazardous ingredients for labelling
2.3

Proteinase, tritirachium album serine

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixturename of substanceidentifier

wt%classification acc. to GHS

Proteinase, tritirachium album serine

CAS No39450-01-6

2

Skin Irrit. 2 / H315
Eye Irrit. 2 / H319
Resp. Sens. 1A / H334

pictograms

for full text of abbreviations: see SECTION 16.

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

United States: en

page: 2 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

date of compilation: 2020-03-24

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

6.3

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

United States: en

page: 3 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

7.2

date of compilation: 2020-03-24

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorless

United States: en

page: 4 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

date of compilation: 2020-03-24

other safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
see below "Conditions to avoid".

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

United States: en

page: 5 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

10.6

date of compilation: 2020-03-24

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
may cause allergy or asthma symptoms or breathing difficulties if inhaled.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

United States: en

page: 6 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

12.5

date of compilation: 2020-03-24

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

United States: en

page: 7 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

date of compilation: 2020-03-24

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic*

chronic (long-term) health effects may result from repeated overexposure

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources BoardCAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

Eye Dam.

Seriously damaging to the eye

Eye Irrit.

Irritant to the eye

United States: en

page: 8 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

proteinase K
version number: GHS 1.0

date of compilation: 2020-03-24

abbr.

descriptions of used abbreviations

GHS"Globally Harmonized System of Classification and Labelling of Chemicals" developed by the United Nations

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

Resp. Sens.

Respiratory sensitization

RTECS

Registry of Toxic Effects of Chemical Substances (database of NIOSH with toxicological information)

Skin Corr.

Corrosive to skin

Skin Irrit.

Irritant to skin

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

list of relevant phrases (code and full text as stated in chapter 2 and 3)
code

text

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H334

May cause allergy or asthma symptoms or breathing difficulties if inhaled.

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 9 / 9Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
Primer pair for meDNA spike-in ctrl

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for meDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 1: Identification
1.1

product identifier
Primer pair for unDNA spike-in ctrl

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

6.3

date of compilation: 2020-04-07

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

9.2

date of compilation: 2020-04-07

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

Primer pair for unDNA spike-in ctrl
version number: GHS 1.0

date of compilation: 2020-04-07

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

date of compilation: 2020-03-24

SECTION 1: Identification
1.1

1.2

product identifiertrade name

TSH2B primer pair

product code(s)C17011041

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis product is composed of synthetic DNA oligonucleotides in an aqueous buffer solution. It does not contain any hazardous
ingredients.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

date of compilation: 2020-03-24

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

6.3

date of compilation: 2020-03-24

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

date of compilation: 2020-03-24

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

9.2

date of compilation: 2020-03-24

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

date of compilation: 2020-03-24

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

date of compilation: 2020-03-24

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

TSH2B primer pairversion number: GHS 1.0

date of compilation: 2020-03-24

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

date of compilation: 2020-02-28

SECTION 1: Identification
1.1

1.2

product identifiertrade name

ChIP-seq grade GAPDH TSS primer pair

product code(s)C17011047

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis product is composed of synthetic DNA oligonucleotides in an aqueous buffer solution. It does not contain any hazardous
ingredients. This mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

date of compilation: 2020-02-28

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

6.3

date of compilation: 2020-02-28

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
personal protective equipment: see section 8. incompatible materials: see section 10. disposal considerations: see section
13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

date of compilation: 2020-02-28

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

9.2

date of compilation: 2020-02-28

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

date of compilation: 2020-02-28

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

date of compilation: 2020-02-28

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App D

ChIP-seq grade GAPDH TSS primer pairversion number: GHS 1.0

date of compilation: 2020-02-28

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 1: Identification
1.1

product identifier
GenDNA Digestion buffer

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

6.3

date of compilation: 2020-04-01

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

date of compilation: 2020-04-01

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

9.2

date of compilation: 2020-04-01

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

date of compilation: 2020-04-01

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA Digestion buffer
version number: GHS 1.0

date of compilation: 2020-04-01

category

degree ofhazarddescription

Flammability

1material that must be preheated before ignition can occur

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

date of compilation: 2020-04-01

SECTION 1: Identification
1.1

product identifier
GenDNA precipitanttrade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

page: 1 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

date of compilation: 2020-04-01

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

6.3

date of compilation: 2020-04-01

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

page: 3 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

date of compilation: 2020-04-01

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
page: 4 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

9.2

date of compilation: 2020-04-01

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidizers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

United States: en

page: 5 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

date of compilation: 2020-04-01

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

page: 6 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

date of compilation: 2020-04-01

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

page: 7 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA precipitantversion number: GHS 1.0

date of compilation: 2020-04-01

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

page: 8 / 8

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 1: Identification
1.1

product identifier
GenDNA TE

trade name1.2

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
nitrogen oxides (NOx)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

6.3

date of compilation: 2020-04-01

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
this information is not available.

8.2

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

date of compilation: 2020-04-01

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient- n-octanol/water (log KOW)
United States: en

this information is not available
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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

9.2

date of compilation: 2020-04-01

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
there is no additional information.

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

date of compilation: 2020-04-01

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

12.6

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability0material that will not burn under typical fire conditions

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA TE
version number: GHS 1.0

date of compilation: 2020-04-01

category

degree ofhazarddescription

Flammability0material that will not burn under typical fire conditions

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources Board

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

PBT

Persistent, Bioaccumulative and Toxic

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 1: Identification
1.1

1.2

product identifiertrade nameGenDNA RNAse (DNAse-free)product code(s)C06060010

relevant identified uses of the substance or mixture and uses advised against
relevant identified uses

1.3

for research use only, not for use in diagnostic ortherapeutic procedures.

details of the supplier of the safety data sheet
Diagenode SA
LIEGE SCIENCE PARK Rue du Bois Saint-Jean, 34102 Seraing
Belgium
telephone: +32 4 364 20 50
e-mail: info@diagenode.com

1.4

emergency telephone number
emergency information service+32 4 364 20 50
this number is only available during the following office hours: Mon-Fri 09:00 AM - 05:00 PM

poison center
country

nametelephone

American Association of Poison Control Centers

1-800-222-1222

SECTION 2: Hazard(s) identification
2.1

classification of the substance or mixture
classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

2.2

label elements
labelling acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
not required

2.3

other hazards
results of PBT and vPvB assessment
this mixture does not contain any substances that are assessed to be a PBT or a vPvB.

SECTION 3: Composition/information on ingredients
3.1

substances
not relevant (mixture)

3.2

mixturesdescription of the mixtureThis mixture does not contain any potentially hazardous products.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 4: First-aid measures4.1

description of first- aid measuresgeneral notes
do not leave affected person unattended. remove victim out of the danger area. keep affected person warm, still andcovered. take off immediately all contaminated clothing. in all cases of doubt, or when symptoms persist, seek medical advice. in case of unconsciousness place person in the recovery position. Never give anything by mouth.

following inhalation
if breathing is irregular or stopped, immediately seek medical assistance and start first aid actions. provide fresh air.

following skin contact
wash with plenty of soap and water.

following eye contact
remove contact lenses, if present and easy to do. Continue rinsing. irrigate copiously with clean, fresh water for at least 10
minutes, holding the eyelids apart.

following ingestionrinse mouth with water (only if the person is conscious). do NOT induce vomiting.

4.2

most important symptoms and effects, both acute and delayed
symptoms and effects are not known to date.

4.3

indication of any immediate medical attention and special treatment needed
none

SECTION 5: Fire-fighting measures
5.1

extinguishing media
suitable extinguishing media
water spray, BC-powder, carbon dioxide (CO2)

unsuitable extinguishing media
water jet

5.2

special hazards arising from the substance or mixture
hazardous combustion products
carbon monoxide (CO), carbon dioxide (CO2)

5.3

advice for firefightersin case of fire and/or explosion do not breathe fumes. coordinate firefighting measures to the fire surroundings. do not allow firefighting water to enter drains or water courses. collect contaminated firefighting water separately. fight fire withnormal precautions from a reasonable distance.

SECTION 6: Accidental release measures
6.1

personal precautions, protective equipment and emergency procedures
for non-emergency personnel
remove persons to safety.

for emergency responders
wear breathing apparatus if exposed to vapors/dust/aerosols/gases.

6.2

environmental precautions
keep away from drains, surface and ground water. retain contaminated washing water and dispose of it.

United States: en

page: 2 / 9

Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

6.3

date of compilation: 2020-04-01

methods and material for containment and cleaning up
advice on how to contain a spillcovering of drains

advice on how to clean up a spill
wipe up with absorbent material (e.g. cloth, fleece). collect spillage: sawdust, kieselgur (diatomite), sand, universal binder

appropriate containment techniques
use of adsorbent materials.

other information relating to spills and releases
place in appropriate containers for disposal. ventilate affected area.

6.4

reference to other sections
hazardous combustion products: see section 5. personal protective equipment: see section 8. incompatible materials: seesection 10. disposal considerations: see section 13.

SECTION 7: Handling and storage
7.1

precautions for safe handlingrecommendations- measures to prevent fire as well as aerosol and dust generation
use local and general ventilation. use only in well-ventilated areas.

advice on general occupational hygiene
wash hands after use. do not eat, drink and smoke in work areas. remove contaminated clothing and protective equipment
before entering eating areas. never keep food or drink in the vicinity of chemicals. never place chemicals in containers thatare normally used for food or drink. keep away from food, drink and animal feedingstuffs.

7.2

conditions for safe storage, including any incompatibilities
control of the effects
protect against external exposure, such as
frost

7.3

specific end use(s)see section 16 for a general overview.

SECTION 8: Exposure controls/personal protection
8.1

control parameters
occupational exposure limit values (Workplace Exposure Limits)country

name of agent

CAS NoidentifierUSglycerine

56-81-5

REL

US

glycerol

56-81-5PEL

US

glycerol

56-81-5

PEL

TWA
[ppm]

TWA
[mg/m³]

STEL
[ppm]

STEL Ceiling-C Ceiling-C nota[mg/m³] [ppm] [mg/m³] tion

sourcemist,
appx-D

NIOSH
REL

15

mist, i29 CFR
1910.100
05

mist, r

29 CFR
1910.1000notation
appx-D
Ceiling-C

United States: en

see Appendix D - Substances with No Established RELs
ceiling value is a limit value above which exposure should not occur

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

date of compilation: 2020-04-01

notation
i
mist
r
STEL
TWA

8.2

inhalable fraction
as mists
respirable fraction
short-term exposure limit: a limit value above which exposure should not occur and which is related to a 15-minute period (unless otherwise specified)time-weighted average (long-term exposure limit): measured or calculated in relation to a reference period of 8 hours timeweighted average (unless otherwise specified

exposure controls
appropriate engineering controls
general ventilation.

individual protection measures (personal protective equipment)eye/face protection
wear eye/face protection.

skin protection- hand protection
wear suitable gloves. chemical protection gloves are suitable, which are tested according to EN 374. check leak-tightness/
impermeability prior to use. in the case of wanting to use the gloves again, clean them before taking off and air them well.
for special purposes, it is recommended to check the resistance to chemicals of the protective gloves mentioned above together with the supplier of these gloves.

- other protection measurestake recovery periods for skin regeneration. preventive skin protection (barrier creams/ointments) is recommended. wash
hands thoroughly after handling.

respiratory protection
in case of inadequate ventilation wear respiratory protection.

environmental exposure controls
use appropriate container to avoid environmental contamination. keep away from drains, surface and ground water.

SECTION 9: Physical and chemical properties
9.1

information on basic physical and chemical properties
appearancephysical stateliquidcolor

colorlessodor

odorlessother safety parameters
pH (value)

not determinedmelting point/freezing point

not determined

initial boiling point and boiling range

not determinedflash point

not determined

evaporation rate

not determined

flammability (solid, gas)

not relevant, (fluid)

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

date of compilation: 2020-04-01

explosive limits

not determined

vapor pressure

not determined

density

not determined

vapor density

this information is not available

relative density

information on this property is not available

solubility(ies)not determinedpartition coefficient9.2- n-octanol/water (log KOW)

this information is not available

auto-ignition temperature

not determinedviscosity

not determined

explosive properties

none

oxidizing properties

none

other information

there is no additional information

SECTION 10: Stability and reactivity
10.1

reactivity
concerning incompatibility: see below "Conditions to avoid" and "Incompatible materials".

10.2

chemical stability
the material is stable under normal ambient and anticipated storage and handling conditions of temperature and pressure.

10.3

possibility of hazardous reactions
no known hazardous reactions.

10.4

conditions to avoid
there are no specific conditions known which have to be avoided.

10.5

incompatible materials
oxidizers

10.6

hazardous decomposition products
reasonably anticipated hazardous decomposition products produced as a result of use, storage, spill and heating are notknown. hazardous combustion products: see section 5.

United States: en

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

date of compilation: 2020-04-01

SECTION 11: Toxicological information
11.1

information on toxicological effects
test data are not available for the complete mixture.

classification procedurethe method for classification of the mixture is based on ingredients of the mixture (additivity formula).

classification acc. to OSHA "Hazard Communication Standard" (29 CFR 1910.1200)
this mixture does not meet the criteria for classification.

acute toxicity
shall not be classified as acutely toxic.

skin corrosion/irritation
shall not be classified as corrosive/irritant to skin.

serious eye damage/eye irritation
shall not be classified as seriously damaging to the eye or eye irritant.

respiratory or skin sensitization
shall not be classified as a respiratory or skin sensitizer.

germ cell mutagenicity
shall not be classified as germ cell mutagenic.

carcinogenicity
shall not be classified as carcinogenic.

reproductive toxicity
shall not be classified as a reproductive toxicant.

specific target organ toxicity - single exposure
shall not be classified as a specific target organ toxicant (single exposure).

specific target organ toxicity - repeated exposure
shall not be classified as a specific target organ toxicant (repeated exposure).

aspiration hazard
shall not be classified as presenting an aspiration hazard.

SECTION 12: Ecological information
12.1

toxicity
shall not be classified as hazardous to the aquatic environment.

12.2

persistence and degradability
data are not available.

12.3

bioaccumulative potential
data are not available.

12.4

mobility in soil
data are not available.

12.5

results of PBT and vPvB assessment
data are not available.

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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

12.6

date of compilation: 2020-04-01

other adverse effects
data are not available.

SECTION 13: Disposal considerations
13.1

waste treatment methods
sewage disposal-relevant information
do not empty into drains. avoid release to the environment. Refer to special instructions/safety data sheets.

waste treatment of containers/packages
completely emptied packages can be recycled. handle contaminated packages in the same way as the substance itself.

remarks
please consider the relevant national or regional provisions. waste shall be separated into the categories that can behandled separately by the local or national waste management facilities.

SECTION 14: Transport information
14.1

UN numbernot subject to transport regulations

14.2

UN proper shipping namenot assigned

14.3transport hazard class(es)not assigned

14.4

packing group

not assigned

14.5

environmental hazards

non-environmentally hazardous acc. to the dangerous goods regulations

14.6

special precautions for user
there is no additional information.

14.7

transport in bulk according to Annex II of MARPOL and the IBC Codethe cargo is not intended to be carried in bulk.

Information for each of the UN Model Regulationstransport of dangerous goods by road or rail (49 CFR US DOT)
not subject to transport regulations.

International Maritime Dangerous Goods Code (IMDG)
not subject to IMDG.

International Civil Aviation Organization (ICAO-IATA/DGR)
not subject to ICAO-IATA.

SECTION 15: Regulatory information
15.1

safety, health and environmental regulations specific for the product in question
national regulations (United States)
VOC content
Regulated Volatile Organic Compounds (VOC-EPA): Regulated Volatile Organic Compounds (VOC-Cal ARB):

industry or sector specific available guidance(s)NPCA-HMIS® III
Hazardous Materials Identification System. American Coatings Association.
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Safety Data Sheetacc. to 29 CFR 1910.1200 App DGenDNA RNAse (DNAse-free)version number: GHS 1.0

date of compilation: 2020-04-01

category

ratingdescription

Chronic/

none

Health0no significant risk to healthFlammability

1material that must be preheated before ignition can occur

Physical hazard

0material that is normally stable, even under fire conditions, and will not react with water,
polymerize, decompose, condense, or self-react. Non-explosive

Personal protection-

NFPA® 704
National Fire Protection Association: Standard System for the Identification of the Hazards of Materials for Emergency Response (United States).
category

degree ofhazarddescription

Flammability

1material that must be preheated before ignition can occur

Health0material that, under emergency conditions, would offer no hazard beyond that of ordinary
combustible material

Instability0material that is normally stable, even under fire conditions

Special hazard

15.2

Chemical Safety Assessment
chemical safety assessments for substances in this mixture were not carried out.

SECTION 16: Other information, including date of preparation or last revisionabbreviations and acronyms
abbr.

descriptions of used abbreviations

29 CFR 1910.1000

29 CFR 1910.1000, Tables Z-1, Z-2, Z-3 - Occupational Safety and Health Standards: Toxic and Hazardous Substances (permissible exposure limits)

49 CFR US DOT

49 CFR U.S. Department of Transportation

Cal ARB

California Air Resources BoardCAS

Chemical Abstracts Service (service that maintains the most comprehensive list of chemical substances)

Ceiling-C

Ceiling value

DGR

Dangerous Goods Regulations (see IATA/DGR)

EPA

Environmental Protection Agency. An agency of the federal government of the United States charged with protecting human health and the environment

IATA

International Air Transport Association

IATA/DGR

Dangerous Goods Regulations (DGR) for the air transport (IATA)ICAOInternational Civil Aviation Organization

IMDG

International Maritime Dangerous Goods CodeMARPOLInternational Convention for the Prevention of Pollution from Ships (abbr. of "Marine Pollutant")

NIOSH REL

National Institute for Occupational Safety and Health (NIOSH): Recommended Exposure Limits (RELs)

NPCA-HMIS® III

National Paint and Coatings Association: Hazardous Materials Identification System - HMIS® III, Third Edition

OSHA

Occupational Safety and Health Administration (United States)

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date of compilation: 2020-04-01

abbr.

descriptions of used abbreviations

PBT

Persistent, Bioaccumulative and Toxic

PEL

Permissible exposure limit

ppm

Parts per million

STEL

Short-term exposure limit

TWA

Time-weighted average

VOC

Volatile Organic Compounds

vPvB

Very Persistent and very Bioaccumulative

key literature references and sources for data
OSHA Hazard Communication Standard (HCS), 29 CFR 1910.1200.
transport of dangerous goods by road or rail (49 CFR US DOT). International Maritime Dangerous Goods Code (IMDG). Dangerous Goods Regulations (DGR) for the air transport (IATA).

classification procedurephysical and chemical properties: the classification is based on tested mixture.
health hazards, environmental hazards: the method for classification of the mixture is based on ingredients of the mixture(additivity formula).

disclaimer
this information is based upon the present state of our knowledge. this SDS has been compiled and is solely intended for thisproduct.

United States: en

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