EAR-BC’07 Scientific Program
Last Update November 8, 2007

Sunday, December 9, 2007
8:30
8:55-9:00
9:00-10:30

10:30-11:00
11:00-12:30

12:30-14:00
14:00-15:30

8:55-17:00

OPEN Registration
Opening Address: Toshiro Tango, Japanese Region President
Opening Ceremony: Introduction to IBS and its regional activities
Chair: Ashwini Mathur (the IBS General Secretary, Indian Region)
Thomas Louis (the IBS President, ENAR) “Our Future as History”
Jiqian Fang (National Group China Secretary) “Outcome Measurement forTCM and Challenge to Statistics”
H. Sridhara (Indian Region President) TBATaerim Lee (Korean Region President) TBA
Toshiro Tango (Japanese Region President) “Major Activities of BiometricSociety of Japan and Japanese Biostatisticians: Past, Present and Future”
Coffee BreakInvited Session: Clinical Trials
Chair. Shigeyuki Matsui (Kyoto University School of Public Health, Japan)
Yuantao Hao (Sun Yat-sen University, China), Jiqian Fang, Xinyuan Song
“Non-linear Factor Analysis Model and its Application to Evaluating theEquivalence of Questionnaires”
Satoshi Morita (Kyoto University Hospital, Japan) “Determining theEffective Sample Size of a Parametric Prior”
Masako Nishikawa (National Institute of Public Health, Japan), Toshiro
Tango, Megu Ohtaki “Simple Statistical Tests for New Composite
Hypotheses in Randomized Clinical Trial Reflecting the Relative Clinical
Importance”
Lunch BreakContributed Session: Epidemiology
Chair: Yutaka Matsuyama (University of Tokyo, Japan)
Ya Fang (University of Xiamen, China) “Probability Prediction in Multistate
Survival Models for Patients with Chronic Myeloid Leukaemia”
Sachiko Tanaka (Tokyo University of Science, Japan) “Inverse Probability
Weighted Estimators in the Stratified Nested Case-Control SamplingMethods”
Koji Yonemoto (Kyushu University, Japan), Atsushi Kawaguchi, Yumihiro
Tanizaki, Yutaka Kiyohara, Takashi Yanagawa, Young K. Truong“Application of Functional ANOVA Models for Hazard Regression to theHisayama Data”

15:00-15:30
15:30-17:30

Shizue Izumi (Oita University, Japan), Yoshinori Fujii “Estimating the Powerof the Likelihood Ratio Test in the Cohort-Based Nested Case-ControlStudies”
Coffee BreakContributed Session: Bioinformatics
Chair: Seiya Imoto (University of Tokyo, Japan)
Tomonori Oura (Kyoto University School of Public Health, Japan),
Shigeyuki Matsui, Koji Kawakami “Sample Size Calculations Based on
Exact Distribution of False Discovery Proportion in Microarray
Experiments”
Akihiro Hirakawa (Pharmaceuticals and Medical Devices Agency, Japan),
Yasunori Sato, Chikuma Hamada, Isao Yoshimura “A Test Statistic Based on
Shrunken Sample Variance for Identifying Differentially Expressed Genes in
Microarray Data Analysis”
Yoichi M. Ito (University of Tokyo, Japan), Yasuo Ohashi “Measurement
Scale Categorization and Its Resolution. A Gene Reduction Approach to theMicroarray Data Analysis”
Takeharu Yamanaka (National Kyushu Cancer Center, Japan), Shigeyuki
Matsui “Survival Prediction Using Top Ranking Significant Genes in CancerPrognostic Studies with Microarrays”
Mira Park (Eulji University, Korea), Yoo-Jin Jang, Myung-Hoe Huh“Applications of Minimal Spanning Tree and Self-Organizing Map inMicroarray Data Analysis”

Monday, December 10, 2007
9:00-10:30

10:30-11:00
11:00-12:00

12:00-13:30
13:30-15:00

15:00-15:30
15:30-17:00

8:55-17:00

Invited Session: Bioinformatics
Chair: Masaaki Matsuura (Japanese Foundation for Cancer Research,Japan)
Jae Won Lee (Korea University, Korea), JunBok Lee, Shin-Jae Lee“Statistical Tools for Protein Identification Based on Mass Spectrometry
Data: A review”Seiya Imoto (University of Tokyo, Japan) “Bioinformatics Approach
Towards Drug Target Gene Discovery”
Masaru Ushijima (Japanese Foundation for Cancer Research) “Analyses ofOMICS Data in Medical Informatics”
Coffee BreakKeynote Lecture
Chair: Thomas Louis (Johns Hopkins Bloomberg School of Public Health,USA)
Toshiro Tango (National Institute of Public Health, Japan) “Tests for Spatial
Randomness: Detection of Disease Clustering and Outbreak Threat”
Lunch BreakInvited Session: Epidemiology
Chair: Tosiya Sato (Kyoto University School of Public Health, Japan)
Ayanendranath Basu (Indian Statistical Institute, India), Sumit Gupta,
Wen-tao Huang “Tests of Hypothesis about the Kappa Statistic based on theGoodness-of-fit Approach”
Satoshi Hattori (Kurume University, Japan), Takashi Yanagawa“Mantel-Haenszel Estimators for Irregular Sparse K 2 X J Tables”
Kunihiko Takahashi (National Institute of Public Health, Japan), Toshiro
Tango “Scan Statistics for Disease Clustering”
Coffee BreakContributed Session: Clinical Trials 1
Chair: Satoshi Morita (Kyoto University Hospital, Japan)
Shiro Tanaka (University of Tokyo, Japan), Yutaka Matsuyama, Yasuo
Ohashi “Estimating Surrogate Endpoints Defined by Principal Causal
Effects”
Anthony Hayter (University of Denver, USA), Chen-ju Lin “RecentAdvances in Stepdown Procedures for Identifying Inferiority Among
Treatments in Clinical Trials”
Takahiro Hasegawa (SHIONOGI & CO., LTD., Japan), Toshiro Tango“Permutation Test Following Covariate-Adaptive Randomization in
Randomized Controlled Trials”

Tetsuhisa Miwa (National Institute for Agro-Environmental Sciences, Japan)“Comparisons Between Three Treatments Including a Placebo and a Control
by the Multiple Confidence Procedure”
17:30-Conference Dinner at Capo PELLICANOTuesday, December 11, 2007
9:00-10:30

10:30-11:00
11:00-12:30

12:30-12:35

9:00-12:35

Contributed Session: Biostatistics in General
Chair: Shizue Izumi (Oita University, Japan)
Lilia L. Ramirez-Ramirez (University of Waterloo, Canada), Mary E.
Thompson “Statistical Inference for Outbreaks in a Population with aContact Network Structure”
Takashi Omori (Kyoto University School of Public Health, Japan), Takashi
Sozu, Isao Yoshimura “Several Challenges by Biostatisticians forDeveloping a New Animal Test Method”
Hyonggin An (Korea University, Korea) “Bayesian Analysis of Repeated
Data with Many Zeros: Application to the Longitudinal Adolescent
Substance Abuse Study”
Tetsushi Komori (Bayer Yakuhin, Ltd., Japan), Takashi Ohmori, Tosiya Sato
“Consistency of Signal Measures with Epidemiologic Effect Measures”
Coffee BreakContributed Session: Clinical Trails 2Chair: Osamu Komiyama (Pfizer Japan Inc., Japan)
KyungMann Kim (University of Wisconsin-Madison, USA) “An
Independent Statistical Center in Support of the Data and Safety Monitoring
Board: The Adenoma Prevention with Celecoxib (APC) Trial”
JungBok Lee (Korea University, Korea) “An Improved Estimating Methodof QT interval for Adjusting Heart Rate: A Multivariate Approach”
Masayuki Henmi (Institute of Statistical Mathematics, Japan), John B.
Copas, Shinto Eguchi “A Sensitivity Analysis Allowing for All Possible
Selection Processes of Studies in Meta Analysis”
Hiroyuki Uesaka (Eli Lilly Japan, Japan) “Sample Size Allocation toRegions in a Multiregional Trial”
Closing Remarks: Tosiya Sato, Scientific Program ChairPoster Session, December 9-10
P01

P02
P03

P04

P05

P06

P07
P08
P09

P10

P11

P12

Satoshi Teramukai (Kyoto University Hospital, Japan), Satoshi Morita“Bayesian Predictive Multi-Stage Design for Phase II Single-Arm Clinical
Trials: A Case Study”
Hyo-Il Park (Chong-ju University, Korea), Soo-Duck Lim, Joong-Jae Cho“Hypothesis Test Under the Additive Hazards Model”
Masahiko Gosho (Kowa Co. Ltd., Japan), Chikuma Hamada, Isao
Yoshimura “Study on the Criterion for Selecting the Working Correlation
Structure in Generalized Estimating Equation”
Yumiko Uematsu (Tokyo University of Science, Japan), Chikuma Hamada,Isao Yoshimura “Statistical Method for Evaluating the Efficacy of a Drug for
Osteoporosis on the Occurrence of Bone Fractures as the Primary Endpoint”
Masayuki Yamada (Tokyo University of Science, Japan), Chikuma Hamada,Isao Yoshimura “Study on the Effect of Random Effects Included in theAnalysis Model for In Vitro Pharmacological Data Adaptable to FourParameter Logistic Model”
Tetsuji Tonda (Hiroshima University, Japan), Kenichi Satoh, Hiromi
Kawasaki, Takeshi Shimamoto, Teruyuki Nakayama, Kota Katanoda,
Tomotaka Sobue, Yasuto Sato, Naohito Yamaguchi, Megu Ohtaki “StatisticalAnalysis of Spatial-Time Heterogeneity of Cancer Mortality Risk Based on
Growth Curve Model”
Kenichi Satoh (Hiroshima University, Japan), Hirokazu Yanagihara“Modified Cp in Multivariate Ridge Regression”
Keiichi Sugino (Mitsubishi Tanabe Pharma Corporation, Japan), Yasuo
Ohashi, Qian Gong “Multinational Clinical Trials in East Asia”
Keiko Otani (Hiroshima University, Japan), Megu Ohtaki, Keiko Hiyama,Kenichi Satoh, Eiso Hiyama “Two Dimensional Summarization forAffymetrix GeneChip Probe Level Data Based on Functional States ofGene-ON/OFF”
Kazue Yamaoka (National Institute of Public Health, Japan), Toshiro Tango“Effects of Lifestyle Modification on Metabolic Syndrome: Resolution Rateand Combining Multiple Endpoints in Meta-Analysis”
Mihoko Minami (Institute of Statistical Mathematics, Japan) “A New
Feature Extraction Method from very Non-Normal Data: Analysis ofMultivariate Catch and Bycatch Data by Purse-Seine Tuna Fisheries”
Yukikazu Hayashi (Tokyo University of Science, Japan), Chikuma Hamada,
IsaoYoshimura“StatisticalPharmacokineticModelingofControlled-Release Analgesics combining Immediate-Release andSustained-Release Components to design an appropriate Drug Delivery”

Domestic Meeting
December 11, 2007

13:30-17:00

Biometric Seminar: Global Clinical Trials (Sponsored by Japanese Biometric Society)