෌㘓 ሗᩥᏳ඲ᕤᏛ ➨ 55 ᕳ 5 ྕ, 357㹼360 (2016)ᡃࡀᅜ࡟࠾ࡅࡿẼ㇟ኚືࡀ㎰స≀࡟ཬࡰࡍᙳ㡪࡜ࡑࡢᑐ⟇∦ᒣెᏊ*  అ⬥⿱୍**ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊 せ᪨ᆅ⌫ ᬮ໬ࡀ㐍ࡳࠊᡃࡀᅜ࡟࠾࠸࡚ࡶẼ ୖ᪼➼࡟ࡼࡿ␗ᖖẼ㇟ࡀᗈࡃほᐹࡉࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁࡓࠋࡑࢀ࡟క࠸ࠊẼ㇟ኚືࡀ㎰స≀࡟ཬࡰࡍᙳ㡪ࡀᠱᛕࡉࢀ࡚࠸ࡿࠋᮏሗᩥ࡟࠾࠸࡚ࡣࠊẼ㇟ኚືࡢせᅉࠊᡃࡀᅜ࡟࠾ࡅࡿẼ㇟ኚືࡢᑗ᮶ண ࠊ ᬮ໬࡟ࡼࡿ㔝⳯ࠊᯝᶞࠊ✐≀࡟ཬࡰࡍᙳ㡪ࠊࡉࡽ࡟Ẽ㇟ኚື࡟ࡼࡿ㎰స≀࡬ࡢᑐ⟇࡞࡝ࢆࡲ࡜ࡵ࡚ᴫㄝࡋ
ࡓࠋᬮ໬࡟ࡼࡿ㎰స≀࡬ࡢ⿕ᐖࡣࠊẼ ୖ᪼࡜క࡟ᣑ኱ࡍࡿࡇ࡜ࡀ⪃࠼ࡽࢀ࡚࠸ࡿࠋࡲࡓࠊ኱㞵ࡸ▷᫬㛫ᙉ㞵ࡢⓎ⏕㢖ᗘࡀቑຍࡍࡿ࡜࠸࠺ண ࠿ࡽࠊ‣Ỉ࣭ෙỈ⿕ᐖࡢᣑ኱ࡶ⪃࠼ࡽࢀࡿࠋ⌧≧࡛ࡢẼ㇟ኚື࡟ࡼࡿ⿕ᐖ࡟ࡣရ✀ࡢ㑅ᢥࠊస௜ࡅ᫬ᮇࡢኚ᭦ࠊ෭༷⿦⨨࡜࠸ࡗࡓᑐᛂ⟇ࡀᏑᅾࡍࡿࡀࠊẼ㇟ኚືࡀண ࡼࡾࡶࡉࡽ࡟῝้໬ࡋࠊẼ㇟ኚື࡟ᑐࡋ࡚⪏ᛶࢆࡶࡗࡓရ✀ࡋ࠿⏕⫱࡛ࡁ࡞࠸⎔ቃ࡟࡞ࡗࡓሙྜ࡟ࡣࠊ㟢ᆅ᱂ᇵࡢከ࠸ᡃࡀᅜ࡟࠾࠸࡚ࠊ㧗 ⪏ᛶࠊᐖ⹸⪏ᛶࠊ⪏Ỉᛶ࡜࠸ࡗࡓ㑇ఏᏊ⤌ࡳ᥮࠼࡟ࡼࡿရ✀ᨵⰋࡀᚲ㡲࡜࡞ࡗ࡚ࡃࡿ࡜ண ࡉࢀࡿࠋࡑࡢሙྜ࡟ࡣ㑇ఏᏊ⤌ࡳ᥮࠼స≀ࡢᏳ඲ᛶ࡟㛵ࡍࡿ᝟ሗ࡜ࡑࡢ㛤♧ࡀᚲせ࡟࡞ࡿ࡜ᛮࢃࢀࡿࠋ Ẽ㇟ኚືࡢᙳ㡪ࡸ⿕ᐖࢆᢚไࡋ࡚࠸ࡃ࡟ࡣࠊ ᐊຠᯝ࢞ࢫ᤼ฟࢆᣢ⥆ⓗ࡟๐ῶࡍࡿᚲせࡀ࠶ࡿࠋ ᐊຠᯝ࢞ࢫࡢ኱ᖜ࡞๐ῶ࡟ࡣࠊᨻᗓࡸ௻ᴗࡢດຊࡔࡅ࡛࡞ࡃᕷẸ࡛ࣞ࣋ࣝࡢ࢚ࢿࣝࢠ࣮ࡢຠ⋡໬ࠊᾘ㈝ᢚไࡀ኱ษ࡟࡞ࡗ࡚ࡃࡿ࡜⪃࠼ࡽࢀࡿࠋᐙᗞ㒊㛛࡟࠾ࡅࡿୡᖏ࠶ࡓࡾࡢ஧㓟໬Ⅳ⣲ࡢ᤼ฟ㔞ࡣ㟁Ẽࡢ౑⏝࠿ࡽࡀࠊ ࣃ࣮ࢭࣥࢺ௨ୖࢆ༨ࡵࡿࡇ࡜࠿ࡽࠊ࢚ࢿࣝࢠ࣮ຠ⋡ࡀ㧗ࡃࠊ஧㓟໬Ⅳ⣲᤼ฟ㔞ࡀᑡ࡞࠸㟁໬〇ရ࡞࡝ࢆ࠸࠿࡟ᬑཬࡉࡏ࡚࠸ࡃ࠿ࡀ㔜せ࡟࡞ࡿࡢ࡛ࡣ࡞࠸ࡔࢁ࠺࠿ࠋ⌧ᅾ࡛ࡣࠊᆅ⌫ ᬮ໬࡟ᑐฎࡍࡿ࡟ࡣࠊࠕ⦆࿴⟇ࠖࡸࠕ㜵Ṇ⟇ࠖ࠿ࡽࠕ㐺ᛂ⟇ࠖࡢẁ㝵࡟ධࡗࡓ࡜࠸࠺ࡢࡀୡ⏺ࡢㄆ㆑࡛࠶ࡿࡢ࡛ࠊ௒ᚋࡣ㎰ᴗᨻ⟇ࡶ኱ࡁࡃኚ໬ࡍࡿࡇ࡜ࡀồࡵࡽࢀ࡚࠸ࡿࠋ−1−෌㘓 ሗᩥᏳ඲ᕤᏛ ➨ 56 ᕳ 5 ྕ, 356㹼361 (2017)࣓࢝ࣛࣝⰍ⣲ࡢ㣗ရ࡬ࡢ฼⏝࡜Ᏻ඲ᛶ∦ᒣెᏊ* ᮧᯇ᫂᪥㤶㸨 అ⬥⿱୍*㸨ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊 せ᪨㣗ရῧຍ≀ࡢ╔Ⰽᩱ࡜ࡋ࡚౑⏝㔞ࡢከ࠸࣓࢝ࣛࣝⰍ⣲࡟ࡘ࠸࡚ࠊࡑࡢ✀㢮ࠊ≉ᚩࠊ᭷⏝ᛶࠊᶵ⬟ᛶࠊ㣗ရ࡬ࡢ฼⏝ࠊẘᛶ࠾ࡼࡧᏳ඲ᛶ࡟ࡘ࠸࡚⪃ᐹࡋࡓࠋ≉࡟ࠊ࣓࢝ࣛࣝⰍ⣲ࡢ〇㐀㐣⛬࡛Ⓨࡀࢇᛶࢆ᭷ࡍࡿ 4-࣓ࢳࣝ࢖࣑ࢲࢰ࣮ࣝࡀ๪⏕ᡂࡉࢀࡿ࡞࡝ࡢᏳ඲ᛶ࡟ࡘ࠸࡚ㅖእᅜ࡟ࡘ࠸࡚ࡢ஦౛ࢆᣲࡆ࡚ヲ㏙ࡍࡿ࡜࡜ࡶ࡟ࠊ࣓࢝ࣛࣝⰍ⣲࡟ࡘ࠸࡚ࡢၥ㢟Ⅼ࠾ࡼࡧㄢ㢟࡟ࡘ࠸࡚ࡶゝཬࡋࡓࠋ࣓࢝ࣛࣝⰍ⣲ࡣࠊ⌧ᅾ౑⏝ࡉࢀ࡚࠸ࡿ㣗ရ⏝╔Ⰽᩱࡢ࡞࠿࡛᭱ࡶ౑⏝㔞ࡀከࡃࠊ᪥ᮏᅜෆࡢ⥲㟂せ㔞ࡢ 80%௨ୖࢆ༨ࡵ࡚࠸ࡿ㣗ရῧຍ≀࡛࠶ࡿࠋ࣓࢝ࣛࣝⰍ⣲ࢆ౑⏝ࡍࡿ┠ⓗࡣ╔Ⰽ࡛࠶ࡾࠊከࡃࡢ㣗ရ࡟౑⏝ࡉࢀ࡚࠸ࡿࠋࡑࡢ⏝㏵
ࡣࠊ㣧ᩱࠊங〇ရࠊࢥ࣮ࣄ࣮ຍᕤရࠊ〇Ⳬ〇ࣃࣥࠊ෭Ⳬࠊࡓࢀ㢮ࠊࢫ࣮ࣉࠊㄪ࿡ᩱࠊఢ↻ࠊₕࡅ≀ࠊ༶ᖍ㣗ရࠊ෭෾㣗ရࠊㄪ⌮῭ຍᕤ㣗ရ➼ࡢ୍⯡ຍᕤ㣗ရࠊὒ㓇ࠊ࣮ࣜ࢟ࣗࣝࠊࢻࣜࣥࢡ๣ࠊ⸆ရࠊ໬⢝ရࠊ࣌ࢵࢺࣇ࣮ࢻ➼㠀ᖖ࡟ᖜᗈ࠸⠊ᅖ࡟ࢃࡓࡗ࡚࠸ࡿࠋ࣓࢝ࣛࣝⰍ⣲ࡣࠊ࣓࢝ࣛࣝϨࠊ࣓࢝ࣛࣝϩࠊ࣓࢝ࣛࣝϪࠊ࣓࢝ࣛࣝϫࡢ 4 ✀㢮ࡀ࠶ࡿࡀࠊ୍ᣓྡ࡛⾲グࡉࢀ࡚࠸ࡿࠋၥ㢟ࡀ࡞ࡅࢀࡤ୍ᣓྡ⾲グ࡛ࡶ࠿ࡲࢃ࡞࠸ࡀࠊࡇࡢ 4 ✀㢮ࡢ࠺ࡕ࣓࢝ࣛࣝϪ࡜࣓࢝ࣛࣝϫ࡟ࡣࠊⓎࡀࢇᛶࢆ᭷ࡍࡿ 4㸫࣓ࢳࣝ࢖࣑ࢲࢰ࣮ࣝࡀ〇㐀㐣⛬࡛๪⏕ᡂ≀㉁࡜ࡋ࡚⏕ᡂࡉࢀ࡚ࡋࡲ࠺ࡓࡵࠊ〇㐀ഃࡣᾘ㈝⪅࡟ 4㸫࣓ࢳࣝ࢖࣑ࢲࢰ࣮ࣝࡀ࡝ࡢ⛬ᗘྵ᭷ࡉࢀ࡚࠸ࡿࡢ࠿ヲ⣽࡟᫂♧ࡍࡿᚲせࡀ࠶ࡿ࡜ᛮࢃࢀࡿࠋ୍᪉ࠊ࣓࢝ࣛࣝⰍ⣲ࡣᡃࡀᅜࢆጞࡵ࢔࣓ࣜ࢝ࠊḢᕞ࡛ࡶẘᛶヨ㦂ࡀ࡞ࡉࢀ࡚࠾ࡾࠊࡑࡢ⤖ᯝࢆᇶ࡟୍᪥ᦤྲྀチᐜ㔞ࡀタᐃࡉࢀ࡚࠸ࡿࡇ࡜࡛ࠊ㣗ရ࡟฼⏝ࡉࢀ࡚࠸ࡿ㣗ရῧຍ≀࡛࠶ࡿࠋᾘ㈝⪅ഃࡢ⚾ࡓࡕࡶ᝟ሗࢆṇࡋࡃ⌮ゎࡋࠊࡑࡢ〇ရࡢ㑅ᢥࡀồࡵࡽࢀ࡚࠸ࡿࠋࡑࢀ࡜ྠ᫬࡟ࠊ௻ᴗഃࡶヲࡋ࠸᝟ሗࡢ㛤♧ࡸ 4㸫࣓ࢳࣝ࢖࣑ࢲࢰ࣮ࣝࡢ⏕ᡂ㔞ࡀᑡ࡞࠸࣓࢝ࣛࣝⰍ⣲ࡢ㛤Ⓨ࡜฼⏝ࢆ✚ᴟⓗ᥎㐍ࡋ࡚࠸ࡃດຊࡀᚲせ࡛࠶ࡿ࡜⪃࠼ࡿࠋ−2−෌㘓 ሗᩥ໬Ꮫ≀㉁࡜⎔ቃ No.142, 11㹼12 (2017)⮬἞య࡟࠾ࡅࡿཷືႚ↮ᑐ⟇ࡢྲྀࡾ⤌ࡳఅ⬥⿱୍*㸨ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊 せ᪨ཷືႚ↮ᑐ⟇࡟ࡘ࠸࡚ࠊ⮬἞య࡛ࡢྲྀࡾ⤌ࡳ≧ἣ࡜ࡑࡢຠᯝࡸၥ㢟Ⅼ➼ࢆゎㄝࡋࡓࠋཷືႚ↮࡟క࠺ၥ㢟࡟ࡣࠊႚ↮⪅௨እࡢ⪅ࡀᙜேࡢពᛮ࡟ಀࡾ࡞ࡃࡓࡤࡇࡢ↮ࢆ྾ࢃࡉࢀࠊ୙ᛌ࡟ឤࡌࡓࡾࠊ⑌⑓ࡢཎᅉ࡜ᡂࡾᚓࡿࡇ࡜࡛࠶ࡿࠋࡇࡢࡓࡵࠊබඹࡢሙᡤ࡛ࡢႚ↮ࡸཷືႚ↮ࢆ⚗Ṇࡍࡿࡓࡵࡢᅜ㝿ⓗ࡞᮲⣙ࡸྛᅜࡢἲᚊ࣭᮲౛࡞࡝ࡀไᐃࡉࢀ࡚࠸ࡿࠋᆅ᪉⾜ᨻ࡟࠾࠸࡚ࡣࠊᆅᇦࡢ୍㒊ࢆࠕ㊰ୖႚ↮⚗Ṇᆅ༊ࠖ࡟ᣦᐃࡋࠊ⨩๎ࢆకࡗࡓ᮲౛ࢆไᐃࡋ࡚࠸ࡿ࡜ࡇࢁࡶ࠶ࡿࠋࡉࡽ࡟ࠊබඹ᪋タࡢ฼⏝⪅ࡢ❧ሙ࠿ࡽࠊᆅ᪉⮬἞య⊂⮬࡛ཷືႚ↮㜵Ṇ᮲౛ࡢไᐃ໬ࡢືࡁࡀࡳࡽࢀ࡚࠸ࡿࠋ⚄ዉᕝ┴࡛ࡣ 2010 ᖺ 4 ᭶ 1 ᪥ࡼࡾࠕ⚄ዉᕝ┴බඹⓗ᪋タ࡟࠾ࡅࡿཷືႚ↮㜵Ṇ᮲౛ࠖࢆ᪋⾜ࡋࡓࠋࡇࡢ᮲౛ࡣࠊཷືႚ↮࡟ࡼࡿ೺ᗣ࡬ࡢᝏᙳ㡪ࢆ㜵Ṇࡍࡿࡓࡵ࡟ࠊ୙≉ᐃࡲࡓࡣከᩘࡢேࡀฟධࡾࡍࡿࡇ࡜ࡀ࡛ࡁࡿ✵㛫㸦බඹⓗ✵㛫㸧ࢆ᭷ࡍࡿ᪋タ㸦බඹⓗ᪋タ㸧࡟࠾࠸࡚ࠊཷືႚ↮ࢆ㜵Ṇࡍࡿࡓࡵࡢ࣮ࣝࣝࢆᐃࡵࡓࡶࡢ࡛࠶ࡿࠋᑐ㇟࡜࡞ࡿ᪋タ⟶⌮⪅ࡣࠊձ᪋タࡢ༊ศ࡟ᛂࡌ࡚ᚲせ࡞ᥐ⨨㸦⚗↮ࠊ⚗↮ࡲࡓࡣศ↮㸧ࢆㅮࡌࡿࡇ࡜ࠊղႚ↮༊ᇦ࡞࡝࡛Ⓨ⏕ࡍࡿࡓࡤࡇࡢ↮ࢆႚ↮⚗Ṇ༊ᇦ࡟ὶฟࡉࡏ࡞࠸ࡇ࡜ࠊճ྾࠸Ẇධࢀࠊ⅊─࡞࡝ࡢჾලࡸタഛࢆ⨨࠿࡞࠸ࡇ࡜ࠊմᮍᡂᖺ⪅ࢆႚ↮༊ᇦ➼࡟❧ࡕධࡽࡏ࡞࠸ࡇ࡜ࠊյ㐪཯ႚ↮⪅࡟ὀពࡍࡿࡇ࡜ࠊն᪋タࡢධࡾཱྀ࡟ࠕ⚗↮ࠖࡸࠕศ↮ࠖ࡞࡝ࡢ⾲♧ࢆᥖ♧ࡍࡿࡇ࡜ࠊ௨ୖ㸴㡯┠ࡢつᐃࢆᏲࡿࡇ࡜ࢆ⩏ົ௜ࡅ࡚࠸ࡿࠋࡇࡢ᮲౛࡟ࡣࠊ⨩๎つᐃࡀ࠶ࡾࠊႚ↮⚗Ṇ༊ᇦ࡛ࡓࡤࡇࢆ྾ࡗࡓࠊ᮲౛࡛つᐃࡉࢀࡓ⩏ົࢆᒚ⾜ࡋ࡞࠸᪋タ⟶⌮⪅㸦5 ୓෇௨ୗ㸧ࡢ⨩๎ࡀ㐺⏝ࡉࢀࡿࠋே㸦2 ୓෇௨ୗ㸧ႚ↮࠾ࡼࡧཷືႚ↮ၥ㢟ࡣࠊ೺ᗣᙳ㡪ࡢ㠃࠿ࡽከࡃࡢᅜẸࡢ㛵ᚰ஦㡯࡛࠶ࡾࠊᅜ࠾ࡼࡧᆅ᪉⮬἞యࡶᮏ᱁ⓗ࡟つไ➼ࡢᑐ⟇ࢆྲྀࡾጞࡵ࡚ࡁࡓ࡜ࡇࢁ࡛࠶ࡿࠋࡇࢀࡽࡢືࡁ࡜ࡑࡢᚋࡢ᥎⛣ࢆὀព῝ࡃぢ࡚࠸ࡃ࡜࡜ࡶ࡟ࠊࢃࢀࢃࢀࡶ࠾஫࠸༠ຊࡋ࡚࠸ࡁ࡞ࡀࡽࠊఫࡳࡼ࠸⎔ቃࢆసࡗ࡚࠸ࡃࡇ࡜ࡀ㔜せ࡛࠶ࡿࠋ−3−෌㘓 ཱྀ㢌Ⓨ⾲᪥ᮏ㣗⏕άᏛ఍ ➨ 54 ᅇ኱఍ㄪ࿡ᡂศࡢᣑᩓ࡟࠾ࡅࡿ 2 ✀ࡢᣑᩓಀᩘࢆ⏝࠸ࡓゎᯒከᒣ㈼஧*  ᒸᮏὒᏊ*  ᶫሙᾈᏊ**ᗈᓥಟ㐨኱Ꮫ೺ᗣ⛉Ꮫ㒊  **ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊㸨せ᪨ㄪ⌮࡟࠾ࡅࡿㄪ࿡ᡂศࡢᾐ㏱ࡣࠊࣇ࢕ࢵࢡࡢᣑᩓಀᩘ D ࢆ୍✀㢮࡜ࡋ࡚ゎᯒࡉࢀ࡚ࡁࡓࠋࡋ࠿ࡋࠊᑠぢᒣࡽࡢᥦၐࡋࡓ஧ඖ཰╔ᣑᩓ⌮ㄽ࡛ࡣࠊศ㓄(p)ᆺ࡜ࣛࣥࢢ࣑ࣗ࢔࣮(L)ᆺ࡛཰╔ࡉࢀࡓ 2 ✀ࡢᣑᩓ✀ࡀᖹ⾮ࢆಖࡕ࡞ࡀࡽᣑᩓࡍࡿࠋࡑࡇ࡛ᮏ◊✲࡛ࡣࠊࡇࡢࢣ࣮ࢫࡀ࡝ࡢࡼ࠺࡞㣗ᮦ࡜ㄪ࿡ᡂศࡢ⤌ࡳྜࢃࡏ࡛㉳ࡇࡿ࠿ࢆ᳨ウࡋࡓࠋ ࣜࣥࢦ࡛ࡣࠊNa+ ࡢ D ࡣࠊ1 ✀㢮ࡢ D ࡛ㄝ࡛᫂ࡁࡓࠋࢥࣥࢽࣕࢡࡢሙྜࠊNa+ ࡢ D ࡶࢢࣝࢥ࣮ࢫࡢ D ࡶ 1 ✀㢮ࡢD ࡛ㄝ࡛᫂ࡁࡓࠋࡋ࠿ࡋ⏕ࡢࢧࢶ࣐࢖࡛ࣔࡣࠊ2 ✀㢮ࡢ D ࢆ௬ᐃࡍࡿࡇ࡜࡛ࠊᐇ ್࡜ࡢࡼ࠸୍⮴ࢆぢࡓࠋࡲࡓࠊணഛຍ⇕ࡋࡓࢧࢶ࣐࢖ࣔࢆࢢࣝࢥ࣮ࢫ⁐ᾮ࡟ᾐₕࡋࡓሙྜ࡟ࡶࠊ2 ✀㢮ࡢ D ࡟ࡼࡗ࡚࠺ࡲࡃㄝ࡛᫂ࡁࡓࠋࡇࢀࡽࡢ⤖ᯝࡼࡾࠊᇶ㉁ࡢ≧ែࡀᏳᐃࡋ࡚࠸࡞࠸ࠕ⏕ࠖࡸ୙ᆒ୍࡞ᵓ㐀ࢆ᭷ࡍࡿ㣗ᮦ࡛ࡢㄪ࿡ᩱࡢᣑᩓࡀࠊ2 ✀㢮ࡢ D ࢆ⤌ࡳྜࢃࡏࡿࡇ࡜࡛ゎᯒ࡛ࡁࡿࡇ࡜ࢆ♧၀ࡋ࡚࠸ࡿࠋ−4−෌㘓 ཱྀ㢌Ⓨ⾲᪥ᮏㄪ蝜⛉Ꮫ఍ᖹᡂ 29 蔷譇኱఍⢥⡿࠿ࡽ〇㐀ࡍࡿ༓茰┴ఏ⤫㣗ရࠕᛶᏛࡶࡕࠖࡢỈศྵ蓫࡜ᐃ᫬ 譇ࡀ≀ᛶ್࡟୚࠼ࡿᙳ㡪ྂᮏ ⨾ᰤ 1,2 ኱ἙཎᝋᏊ 1 ᑠ⏣୰༡ᘪ 1 ᾏ⪁⃝㝯ྐ 3 ሷ㇂ ᩄ᫂ 3 ୰ᓥ ⫕ 1,41 ࿴ὒዪᏊ኱Ꮫ 2 ே㛫⥲ྜ⛉Ꮫ኱Ꮫ኱Ꮫ㝔 3 ᮾி⪷ᰤ኱Ꮫ 4 ࿴ὒዪᏊ኱Ꮫ኱Ꮫ㝔せ᪨࠙┠ⓗࠚᛶᏛࡶࡕࡣࠊỤᡞ᫬௦ࡢ㎰ᴗᣦᑟ⪅࣭኱ཎᗃᏛࡀ⌧༓茰┴㤶ྲྀ࣭ᾏ໳ᆅᇦࡢ㈋ࡋ࠸㎰Ẹࡢࡓࡵ࡟ᑟධࡋࡓࠊ⡿⢊ࢆ౑ࢃࡎࠊ螨≧ࡢ⢥⡿ࢆ౑⏝ࡋ࡚〇㐀ࡍࡿ㣰ᵝ㣗ရ࡛࠶ࡿࠋᛶᏛࡶࡕࡣࠕ㣧ࡳ㎸ࡳࡸࡍ࠸ࠖ
ࠊࠕ↻㎸ࡳ蘦蝜࡛ᔂࢀ࡟ࡃ࠸ࠖ࡜࠸࠺≉ᛶ࠿ࡽࠊ⌧௦ࡢ㣗ရ࡜ࡋ࡚貱┤ࡉࢀ࡚࠸ࡿࠋᡃࠎࡣࠊ᫖蔷ࡢᮏᏛ఍࡛ࠊᛶᏛࡶࡕࡣ㣰ࡼࡾࡶࠊࠕ㣧ࡳ㎸ࡳ蝖ࡉࠖࠊࠕจ㞟ᛶࡢపࡉࠖࡀࠊඃࢀ࡚࠸ࡿࡇ࡜ࢆሗ࿌ࡋࡓࠋ௒ᅇࡣࠊᛶᏛࡶࡕࡢỈศྵ蓫࡜ ᐃ 譇ࡀ≀ᛶ࡟୚࠼ࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ࠙᪉ἲࠚTA XT Plus(TA ♫)௜ᒓࡢ࣌ࣝࢳ࢙ᘧㄪ ࢳࣕࣥࣂ࣮ࢆ⏝࠸ 60ࠊ40ࠊ25Υ࡟ࢳࣕࣥࣂ࣮ෆࢆಖᣢࡋ࡚≀ᛶᐃࢆ豬ࡗࡓࠋࢸࢡࢫࢳ࣮ࣕゎᯒࡣ 5mm ࡢࢫࢸࣥࣞࢫ〇ࣉࣛࣥࢪ࣮ࣕࢆ⏝࠸ࠊ80%ᅽ⦰蜛࡛ ᐃࡋࡓࠋᗃᏛࡀఏ࠼ࡓㄪ〇ἲ(ᗃᏛἲ)࡜ࠊ⵨ࡋᕤ⛬᫬ࡢ᣺ࡾỈࢆ豬࠺ࡇ࡜࡛ᗃᏛἲࡼࡾỈศྵ蓫ࡀ㧗࠸ᛶᏛࡶࡕࡢ஧✀㢮ࢆㄪ〇ࡋࡓ(᣺ࡾỈἲ)ࠋ
ᑐ↷࡜ࡋ࡚㣰⡿ࢆ⏝࠸࡚ㄪ〇ࡋࡓ㣰(⮬ᐙ〇㣰)ࢆ⏝࠸ࡓࠋ࠙⤖ᯝࠚᗃᏛἲᛶᏛࡶࡕ(Ỉศྵ蓫 50.8%)ࢆ 25Υ࡛ࢸࢡࢫࢳ࣮ࣕゎᯒࢆ豬ࡗࡓ࡜ࡇࢁࠊ⮬ᐙ〇㣰(Ỉศྵ蓫 39.4%)࣭᣺ࡾỈἲᛶᏛࡶࡕ(Ỉศྵ蓫 56.7%)ࡢ࡝ࡕࡽࡼࡾࡶ௜╔ᛶࡀ㧗ࡃࠊจ㞟ᛶࡣప࠿ࡗࡓࠋ୍᪉ࠊ࡛ࢇ࡫ࢇࡢ緢໬ࡀᢚไࡉࢀࡿ 60Υ࡛≀ᛶࢆ ᐃࡋࡓ࡜ࡇࢁࠊ25Υ࡛ࡢྛ≀ᛶ್࡟ẚ࡭኱ࡁࡃኚ໬ࡋࡓࠋࡉࡽ࡟ࠊᗃᏛἲ࡜᣺ࡾỈἲ࡛ㄪ〇ࡋࡓᛶᏛࡶࡕࢆẚ㍑ࡋࡓ࡜ࡇࢁࠊỈศྵ蓫ࡀቑ࠼ࡿ࡜ࠊ ᐃ 譇࡟㛵ࢃࡽࡎࠊ௜╔ᛶࡣపࡃ࡞ࡾࠊจ㞟ᛶࡣ㧗ࡃ࡞ࡗࡓࠋỈศྵ蓫࡜ ᐃ 譇࡟ࡼࡗ࡚ࢸࢡࢫࢳ࣮ࣕࡀኚ໬ࡍࡿࡇ࡜࠿ࡽࠊᛶᏛࡶࡕࡢ≀蝜≉ᛶࡢゎᯒ࡟ࡣỈศ蓫࡜ ᐃ᮲௳ࢆ㐺誅࡟⟶蝜ࡍࡿᚲせࡀ࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋ−5−෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏᐙᨻᏛ఍ ➨ 69 ᅇ኱఍ࢿ࣮࣒(ࢱ࢖ࡢⓎ㓝ࢯ࣮ࢭ࣮ࢪ)ࡢႴዲᛶࡢ᳨ウⲨᮌ⿱Ꮚ ᒣᮏ┤Ꮚ ᒾᓮᬛ⿱ ᆏᮏ⪷ே ୸஭ṇᶞᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊 せ᪨࠙┠ⓗࠚࢿ࣮࣒࡜ࡣࢱ࢖ࡢⓎ㓝ࢯ࣮ࢭ࣮ࢪ࡛࠶ࡿࠋࢿ࣮࣒ࡣங㓟Ⓨ㓝࡟ࡼࡾࠊᚤ⏕≀ࡢ⦾Ṫࢆᢚไࡋ࡚࠾ࡾࠊ⏕㣗࡛ࡁࡿࡢࡀ኱ࡁ࡞≉ᚩ࡛࠶ࡿࠋᮏ◊✲࡛ࡣࢿ࣮࣒ࡢႴዲᛶࢆ᳨ウࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࠊ≀ᛶࠊங㓟㔞ࠊ㹮H ࡢ⤒≉ⓗኚ໬ࢆほᐹࡋࡓࠋࡲࡓࠊ⣽⳦᳨ᰝ࡟ࡼࡿᏳ඲ᛶࡢ᳨ウࡶ⾜ࡗࡓࠋ࠙᪉ἲࠚヨ㦂ヨᩱࡣㄪ〇ᮦᩱࡢࡳࡢ⮬↛Ⓨ㓝༊࡜ᮦᩱ࡟ࢿ࣮࣒ࣃ࢘ࢲ࣮ࠊ↓Ỉࢢࣝࢥࣥ㓟ࠊ࣮ࣚࢢࣝࢺࢆῧຍࡋࡓ 4 ✀㢮ࢆㄪ〇ࡋࠊ35Υ࡛ 4 ᪥㛫Ⓨ㓝ࡉࡏࠊ≀ᛶࠊங㓟㔞ࠊ㹮H ࢆ ᐃࡋࠊங㓟⳦ᩘ࡜኱⭠⳦⩌࡟ࡼࡿᏳ඲ᛶࡢ᳨ウࢆ⾜ࡗࡓࠋ࠙⤖ᯝࠚங㓟㔞࡜㹮H ࡣⓎ㓝ࡀ㐍ࡴ࡟ࡘࢀங㓟㔞ࡀቑຍࡋ㹮H ࡢῶᑡࡀぢࡽࢀࡓࠋ୰࡛ࡶࢢࣝࢥࣥ㓟ῧຍ༊࡜ࢿ࣮࣒ࣃ࢘ࢲ࣮ῧຍ༊ࡀ㢧ⴭ࡛࠶ࡗࡓࠋ≀ᛶࡢ ᐃ࡛ࡣㄪ〇᪉ἲ࡟ࡼࡾࠕ࠿ࡓࡉࠖࠕจ㞟ᛶࠖ࡟ᕪࡀฟࡓࡀ᏶ᡂ᫬࡟ࡣ࡯ࡰྠࡌ್ࢆ♧ࡋࡓࠋ᏶ᡂ᫬ࡢ⣽⳦᳨ᰝ࡛ࡣࢢࣝࢥࣥ㓟ῧຍ༊ࠊࢿ࣮࣒ࣃ࢘ࢲ࣮ῧຍ༊࡛ࡣ኱⭠⳦⩌ࡣ༑ศᢚไࡉࢀ࡚࠸ࡓࡀࠊ௚ࡢ 2 ༊࡛ࡣ኱⭠⳦⩌ࡢᢚไࡣ༑ศ࡛ࡣ࡞࠿ࡗࡓࠋ⮬↛Ⓨ㓝༊࡜࣮ࣚࢢࣝࢺῧຍ༊࡛ࡣⓎ㓝ࡀ㐍ࡴ࡟ࡘࢀࠊங㓟⳦ᩘࡢ኱ࡁ࡞ቑຍࡀぢࡽࢀࠊ㐺ᗘ࡞㓟࿡ࡀႴዲᛶ࡟㈉⊩ࡋ࡚࠸ࡿࡇ࡜ࡀ⪃࠼ࡽࢀࡓࠋ4 ✀ࡢㄪ〇᪉ἲ࡛ࡣࠊ࣮ࣚࢢࣝࢺῧຍ༊ࡢㄪ〇ࡀ⡆౽࡛ࠊ᏶ᡂࡋࡓࢿ࣮࣒ࡢᛶ≧ࡶඃࢀ࡚࠸ࡓࠋ−6−෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏᐙᨻᏛ఍ ➨ 69 ᅇ኱఍㸦ᖹᡂ 29 ᖺ 5 ᭶ 28 ᪥㸧࣐࣮࢟࣋ࣜࡢᢠ㓟໬άᛶ࡟ࡘ࠸࡚
‫∦ۑ‬ᒣెᏊ, ⱝᑿᘺ⨾ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊せ᪨࠙┠ⓗࠚ࣐࣮࢟࣋ࣜ(Aristotelia chilensis)ࡣࠊࢳࣜࡢࣃࢱࢦࢽ࢔࡜࿧ࡤࢀࡿᐮ෭ᆅᖏࡀཎ⏘ᆅ࡛࠶ࡾࠊ࣏ࣝࢺࣀ࢟⛉ࡢ᳜≀࡛ࣈ࣮࣮ࣝ࣋ࣜ࡟ࡼࡃఝ࡚࠸ࡿࠋᯝᐇࡣࠊ┤ᚄ⣙ 6mm ࡢ⌫ᙧ࡛ࡘࡸࡢ࠶ࡿ㯮⣸Ⰽࠊ཰✭᫬ᮇࡣ 1㹼3 ᭶࡛࠶ࡿࠋ࣐࣮࢟࣋ࣜࡀ᭱ࡶὀ┠ࡉࢀ࡚࠸ࡿࡢࡣࠊ࣏ࣜࣇ࢙ࣀ࣮ࣝ࡜ᢠ㓟໬ຊ࡛ࠊࡑࡢ௚࡟ࡶࣅࢱ࣑ࣥ Cࠊ㕲ࠊ࣒࢝ࣜ࢘࡞࡝ࡢྵ᭷㔞ࡶ㧗࠸࡜ゝࢃࢀ࡚࠸ࡿࠋࡑࡇ࡛ᮏ◊✲࡛ࡣࠊࣅࢱ࣑ࣥ Cࠊ㕲ศ࠾ࡼࡧ࣏ࣜࣇ࢙ࣀ࣮ࣝࡢᐃ㔞ࢆ⾜࠺࡜࡜ࡶ࡟ᢠ㓟໬άᛶ࡟ࡘ࠸࡚ ᐃࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ࠙᪉ἲࠚࣅࢱ࣑ࣥ C ࡢ ᐃࡣࠊ࢖ࣥࢻࣇ࢙ࣀ࣮࣭ࣝ࢟ࢩࣞࣥἲ࡟ࡼࡾࠊ㕲ศࡢ ᐃࡣࠊ1,10-ࣇ࢙ࢼࣥࢺࣟࣜࣥἲ࡟ࡼࡾ⾜ࡗࡓࠋ࣏ࣜࣇ࢙ࣀ࣮ࣝྵ᭷㔞 ᐃࡣࠊFolin-Ciocalteu ἲࢆ⏝࠸࡚ ᐃࡋࠊἐ㣗Ꮚ㓟┦ᙜ㔞࡜ࡋ࡚⟬ฟࡋࡓࠋᢠ㓟໬άᛶ ᐃࡣࠊࣛࢪ࢝ࣝᾘཤ⬟ࢆ DPPH ἲ࡟ࡼࡾ⾜࠸ࠊࡲࡓ DPPH ࣛࢪ࢝ࣝᾘཤάᛶࡣ Trolox ┦ᙜ㔞࡜ࡋ࡚⟬ฟࡋࡓࠋ࠙⤖ᯝࠚࣅࢱ࣑ࣥ C ࡑࡋ࡚㕲ศ㔞ࡣࣈ࣮࣮ࣝ࣋ࣜࡼࡾ㧗ࡃࠊ࣏ࣜࣇ࢙ࣀ࣮ࣝ㔞ࡣ࢔ࢧ࢖࣮ࡸ࢔ࢭࣟࣛࡼࡾࡶ㧗࠸⤖ᯝ࡜࡞ࡗࡓࠋᢠ㓟໬άᛶࡣࠊ࢔ࢧ࢖࣮ࡸࢥࢥ࢔ࣃ࢘ࢲ࣮࡜ẚ㍑ࡍࡿ࡜㧗࠸ᢠ㓟໬άᛶࢆ♧ࡋࡓࠋࡲࡓࠊ࣏ࣜࣇ࢙ࣀ࣮ࣝ㔞࡜ᢠ㓟໬άᛶࡀ࡜ࡶ࡟㧗࠸್ࢆ♧ࡋࡓࡇ࡜࠿ࡽ࣐࣮࢟࣋ࣜࡢᢠ㓟໬άᛶࡢ୺యࡣ࣏ࣜࣇ࢙ࣀ࣮࡛ࣝ࠶ࡿࡇ࡜ࡀ⪃࠼ࡽࢀࡓࠋࡇࡢࡇ࡜࠿ࡽࠊ࣐࣮࢟࣋ࣜࡣࣅࢱ࣑ࣥ C ࡜㕲ศࡣࣈ࣮࣮ࣝ࣋ࣜࡼࡾ㧗ࡃࠊ࣏ࣜࣇ࢙ࣀ࣮ࣝࢆከࡃྵ᭷ࡋࠊ㧗࠸ᢠ㓟໬άᛶࡀᮇᚅ࡛ࡁࡿ㣗ရ࡛࠶ࡿࡇ࡜ࡀ᫂ࡽ࠿࡜࡞ࡗࡓࠋ−7−෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏㄪ⌮⛉Ꮫ఍ ᖹᡂ 29 ᖺᗘ኱఍㸦ᖹᡂ 29 ᖺ 8 ᭶ 31 ᪥㸧ࣞࢵࢻࣅ࣮ࢺࡢ⫧኱᰿࡟࠾ࡅࡿ࣋ࢱࣞ࢖ࣥྵ㔞࠾ࡼࡧ DPPH ࣛࢪ࢝ࣝᾘཤάᛶ
‫∦ۑ‬ᒣెᏊ 1, ቑ⏣᱈Ꮚ 1, ຍ⸨෇ె 2, ᴯᯘ㞞㈗ 2, ඖᮌ ᝅ 2(1 ᮾி⪷ᰤ኱, 2 ᫂἞኱)せ᪨࠙┠ⓗࠚ㏆ᖺࠊᾘ㈝⪅ࡢ೺ᗣᚿྥࡀ㧗ࡲࡾࠊᶵ⬟ᛶᡂศࢆከࡃྵࡴ㔝⳯ࡀὀ┠ࡉࢀࡿࡼ࠺࡟࡞ࡗ࡚ࡁࡓࠋḢ⡿࡛ࡣᐃ␒㔝࡛⳯࠶ࡿࣄࣘ⛉᳜≀ࡢࣞࢵࢻࣅ࣮ࢺࡣࠊ࣋ࢱࣞ࢖ࣥࢆከࡃྵ᭷ࡋ࡚࠸ࡿࡇ࡜ࡀ▱ࡽࢀ࡚࠾ࡾࠊᢠ㓟໬⬟ࡣ࢔ࢫࢥࣝࠋࡑࡇ࡛ᮏ◊✲࡛ࡣࠊࣞࢵࢻࣅ࣮ࢺࡢᡂ㛗᫬ᮇูࡢ࣋ࢱࣞ࢖ࣥࣅࣥ㓟ࡼࡾࡶᙉຊ࡛࠶ࡿ࡜ሗ࿌ࡉࢀ࡚࠸ࡿ㸦๓⏣,2009㸧ྵ㔞ࡢẚ㍑ࢆ⾜࠺࡜࡜ࡶ࡟ࠊᢠ㓟໬άᛶ࡜ࡢ㛵ಀࢆ᫂ࡽ࠿࡟ࡍࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ࠙᪉ἲࠚヨᩱࡣࠊ᫂἞኱Ꮫ⏕⏣࢟ࣕࣥࣃࢫࡢ㟢ᆅᅡሙ࡛཰✭ࡉࢀࡓࣞࢵࢻࣅ࣮ࢺ㸦ࢹࢺࣟ࢖ࢺ࣭ࢲ࣮ࢡࣞࢵࢻ㸧ࡢ᫓᧛ࡁ㸦3 ᭶ୗ᪪㸧ࡢྍ㣗㒊࡛࠶ࡿ⫧኱᰿㸦ᢳ᰿ᮇࠊ㐺ᮇࠊ㐣⇍ᮇ㸧ࢆ౑⏝ࡋࡓࠋ࣋ࢱࣞ࢖ࣥ㸦࣋ࢱࢩ࢔ࢽࣥࠊ࣋ࢱ࢟ࢧࣥࢳࣥ㸧ྵ㔞ࡢ ᐃࡣࠊヨᩱ⁐ᾮࢆศගගᗘィ㸦UVmini-1240,SHIMADZU ♫〇㸧ࢆ⏝࠸࡚྾ගᗘࢆ ᐃࡋྵ㔞ࢆ⟬ฟࡋࡓࠋᢠ㓟໬άᛶࡣࠊࣛࢪ࢝ࣝᾘཤ⬟ࢆ DPPH ἲ࡟ࡼࡾ ᐃࡋࡓࠋࡲࡓ DPPH ࣛࢪ࢝ࣝᾘཤ⬟ࡣ Trolox ┦ᙜ㔞࡜ࡋ࡚⟬ฟࡋࡓࠋ࠙⤖ᯝࠚ࣋ࢱࢩ࢔ࢽࣥ࠾ࡼࡧ࣋ࢱ࢟ࢧࣥࢳࣥྵ㔞ࡣᢳ᰿ᮇࡀ᭱ࡶ㧗ࡃࠊḟ࡟㐣⇍ᮇࠊࡑࡋ࡚㐺ᮇࡢ㡰࡛࠶ࡾࠊ㐣⇍ᮇ࡜㐺ᮇ࡛ࡣ࠶ࡲࡾᕪࡀぢࡽࢀ࡞࠿ࡗࡓࠋDPPH ࣛࢪ࢝ࣝᾘཤ⬟ࡣᢳ᰿ᮇࡀ᭱ࡶ㧗ࡃࠊḟ࡟㐺ᮇࠊࡑࡋ࡚㐣⇍ᮇࡣ᭱ࡶప࠸್࡜࡞ࡗࡓࠋࡲࡓࠊ୧⪅ࡢ㛵ಀࢆぢࡓ࡜ࡇࢁࠊ࣋ࢱࢩ࢔ࢽࣥ࠾ࡼࡧ࣋ࢱ࢟ࢧࣥࢳࣥࡢ 2 ✀ࡢ࣋ࢱࣞ࢖ࣥ࡜ DPPH ࣛࢪ࢝ࣝᾘཤάᛶ࡜ࡢ㛫࡟ࡣ㧗࠸ṇࡢ┦㛵㛵ಀࡀㄆࡵࡽࢀࠊࣞࢵࢻࣅ࣮ࢺࡢᢠ㓟໬άᛶࡣ࣋ࢱࣞ࢖ࣥ⏤᮶࡟ࡼࡿࡶࡢ࡛࠶ࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋࡲࡔ᪥ᮏ࡛ࡣ㥆ᰁࡳࡢᑡ࡞࠸ࣞࢵࢻࣅ࣮ࢺ࡛ࡣ࠶ࡿࡀࠊ㧗࠸ᢠ㓟໬άᛶࢆ᭷ࡋ࡚࠸ࡿ㔝࡛⳯࠶ࡿࡓࡵࠊ௒ᚋࡢࡉࡽ࡞ࡿᾘ㈝ᣑ኱࡟⧅ࡀࢀࡤ࡜⪃࠼ࡿࠋ−8−෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏㄪ⌮⛉Ꮫ఍ ᖹᡂ 29 ᖺᗘ኱఍㸦ᖹᡂ 29 ᖺ 8 ᭶ 31 ᪥㸧ရ✀ࠊつ᱁ู࠾ࡼࡧ཰✭᫬ᮇู࡟࠾ࡅࡿ࢔ࢫࣃࣛ࢞ࢫࡢᢠ㓟໬άᛶ‫ۑ‬௒஭ᓧᖹ 1㸪 ከ⏣㯞⌮ 2㸪 ⏣ཱྀ ᕦ 3㸪 ඖᮌ ᝅ 3㸪 ∦ᒣెᏊ 2㸦1 ᫂἞኱࣭㝔㸪2 ᮾி⪷ᰤ኱㸪3 ᫂἞኱㸧せ᪨࠙┠ⓗࠚ࢔ࢫࣃࣛ࢞ࢫࡣࠊࣝࢳࣥ࡞࡝ࡢᶵ⬟ᛶᡂศࢆከࡃྵࡳࠊᢠ㓟໬άᛶࡢ㧗࠸㔝⳯ࡢ୍ࡘ࡛࠶ࡿࠋ཰✭ㄪ〇ᚋࡢⱝⱼࡢ㔜㔞ࡀ኱ࡁࡃࠊⱼᚄࡀኴ࠸ࡶࡢ࡯࡝㧗༢౯࡛ྲྀᘬࡉࢀ࡚࠸ࡿࠋᮏ◊✲࡛ࡣࠊ୍⯡ⓗ࡟ᗈࡃὶ㏻ࡋ࡚࠸ࡿࢢ࣮ࣜࣥ࢔ࢫࣃࣛ࢞ࢫ࡟ຍ࠼ࠊࢢ࣮ࣜࣥ࡟ẚ࡭࡚ࣝࢳࣥ࡞࡝ࡢᶵ⬟ᛶᡂศ࡟ඃࢀࠊ௒ᚋࡢ㟂せቑຍࡀᮇᚅࡉࢀࡿ࣒ࣛࢧ࢟࢔ࢫࣃࣛ࢞ࢫࡢつ᱁ู࠾ࡼࡧ཰✭᫬ᮇูࡢᢠ㓟໬άᛶࢆ᳨ドࡋࡓࠋ࠙᪉ἲࠚ౪ヨᮦᩱࡣࠊ᫂἞኱ࡢ㟢ᆅᅡሙ࡛᱂ᇵࡋࡓ࢙࣒͂࢘ࣝ࢝̓㸦ࢢ࣮ࣜࣥ࢔ࢫࣃࣛ࢞ࢫ㸧࠾ࡼࡧ͂‶࿡⣸̓㸦࣒ࣛࢧ࢟࢔ࢫࣃࣛ࢞ࢫ㸧ࡢ 2LࠊLࠊM ࠾ࡼࡧ S ⣭つ᱁ࡢⱝⱼࢆศᯒᑐ㇟࡜ࡋࡓࠋ⢾ᗘࡣࢹࢪࢱࣝ⢾ᗘィࠊ࢔ࢫࢥࣝࣅࣥ㓟ࡣRQ ࣇࣞࢵࢡࢫࠊ◚᩿ᛂຊࡣᑠᆺ༟ୖヨ㦂ᶵ࡛ ᐃࡋࡓࠋᢠ㓟໬άᛶࡣࠊࣛࢪ࢝ࣝᾘཤ⬟ࢆ DPPH ἲ࡟ࡼࡾ ᐃࡋࡓࠋࡲࡓࠊDPPH ࣛࢪ࢝ࣝᾘཤ⬟ࡣ Trolox ┦ᙜ㔞࡜ࡋ࡚⟬ฟࡋࡓࠋ࠙⤖ᯝࠚᢠ㓟໬άᛶࡣࠊ࢙࣒͂࢘ࣝ࢝̓ࡢ᫓࡝ࡾ࡛ࡣ S ⣭ࡀ࡯࠿ࡢつ᱁࡟ẚ࡭࡚᭷ព࡟㧗ࡃࠊኟ⛅࡝ࡾ࡛ࡣ᫓࡝ࡾ࡟ẚ࡭࡚つ᱁㛫ᕪࡀᑠࡉ࠿ࡗࡓࠋ͂‶࿡⣸̓ࡣ࠸ࡎࢀࡢ཰✭᫬ᮇ࡟࠾࠸࡚ࡶࠊS ⣭ࡀ࡯࠿ࡢつ᱁࡟ẚ࡭࡚᭷ព࡟㧗࠿ࡗࡓࠋ͂࢘࢔ࢫࢥࣝࣅࣥ㓟ࡣࠊS ⣭ࡀ࡯࠿ࡢつ᱁࡟ẚ࡭࡚᭷ព࡟㧗ࡃࠊ⢾ᗘ࡛ࡣつ᱁㛫ᕪࡀ☜ㄆ࡛ࡁ࡞࠿ࡗࡓࠋ◚᩿ᛂຊࡣࠊ࢙࣒࡛ࣝ࢝̓ࡣ⣽࠸つ᱁࡯࡝ప࠸ഴྥ࡛࠶ࡗࡓࡀࠊ͂‶࿡⣸࡛̓ࡣつ᱁㛫ᕪࡀ☜ㄆ࡛ࡁ࡞࠿ࡗࡓࠋ௨ୖࡢ⤖ᯝࠊ͂‶࿡⣸̓ࡣ཰✭᫬ᮇ࡟㛵ࢃࡽࡎࠊS ⣭ࡀᑠ኎ᗑ࡞࡝࡛ᗈࡃ㈍኎ࡉࢀ࡚࠸ࡿ L ࡸ M ⣭࡟ẚ࡭࡚㧗࠸ᢠ㓟໬ຊࢆ᭷ࡍࡿࡇ࡜ࡀ᫂ࡽ࠿࡟࡞ࡗࡓࠋࡑࡢࡓࡵࠊฟⲴྍ⬟࡞㔜㔞࡟‶ࡓࡎ࡟ᗫᲠࡉࢀࡿ⣽࠸ⱝⱼ࡟࠾࠸࡚ࡶࠊᶵ⬟ᛶ㣗ရࡢ⣲ᮦ࡜ࡋ࡚ࡢ฼⏝౯್ࡀ࠶ࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ−9−෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏ⤥㣗⤒Ⴀ⟶⌮Ꮫ఍Ꮫ⾡⥲఍ ➨ 13 ᅇ኱఍⤥㣗⤒Ⴀ⟶⌮ᐇ⩦࠿ࡽᆅᇦ࡟ྥࡅࡓാࡁ࠿ࡅ ̿࠿ࡘࡋ࠿ࡢඖẼ㣗ᇽ᥎㐍஦ᴗࡢ஦౛̿㢼ぢබᏊࠊ᳜ᯇ⠇Ꮚࠊྜྷ⏣┿▱Ꮚࠊᰘ⏣㝯୍ࠊ୰ᮧ㯞⾰ࠊబஂ㛫ಇᖾࠊ㧗ᶫ㯞㔛Ꮚࠊᑠᯘ㝧ᏊࠊᶫሙᾈᏊࠊ㕥ᮌ୕ᯞࠊ᪂ᮧ┾⏤⨾ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊 せ᪨࠙┠ⓗࠚᮏᏛ࡛ࠊᖹᡂ 26 ᖺᗘ࠿ࡽⴱ㣭༊ࡢእ㣗ࡢ㣗⎔ቃᩚഛࠊᆅᇦ࡟᰿ᕪࡋࡓ㣗⫱ࡢ᥎㐍ࠊ༊Ẹࡢ೺ᗣࡢ⥔ᣢ࣭ቑ㐍ࢆᅗࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓⴱ㣭ࡢඖẼ㣗ᇽ᥎㐍஦ᴗࡢ୍㒊ࢆᢸࡗ࡚࠸ࡿࠋ⤥㣗⤒Ⴀ⟶⌮◊✲ᐊ࡛ࡣ࣓ࢽ࣮ࣗཬࡧࣞࢩࣆ࣮࢝ࢻࡢ㛤Ⓨࠊ༊Ẹࢆᑐ㇟࡜ࡋࡓヨ㣗఍ࢆᐇ᪋ࡋ࡚࠸ࡿࠋࡑࡇ࡛ࠊヨ㣗఍࡟ཧຍࡋࡓ༊Ẹ࡜஦ᴗ࡟ཧຍࡋࡓᏛ⏕ࡢពぢࢆࡲ࡜ࡵࠊ௒ᚋ஦ᴗࢆⓎᒎࡉࡏࡿࡓࡵࡢ㈨ᩱࢆᚓࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋ࠙᪉ἲࠚᖹᡂ 28 ᖺ 9 ᭶ 22 ᪥࡟ヨ㣗఍ཧຍࡢ༊Ẹ 45 ྡ࡜஦ᴗ࡟ཧຍࡢ⟶⌮ᰤ㣴Ꮫ⛉ 3 ᖺ⏕ 55 ྡ࡟࢔ࣥࢣ࣮ࢺࢆᐇ᪋ࡋࡓࠋ࢔ࣥࢣ࣮ࢺ࡟㛵ࡋ࡚ࡣᮾி⪷ᰤ኱Ꮫࡢ೔⌮ጤဨ఍࡛ᢎㄆࢆᚓࡓࠋ࣓ࢽ࣮ࣗࡣࠊ⤥㣗⤒Ⴀ⟶⌮ᐇ⩦Ϩ࡛సᡂࡋࡓ 18࣓ࢽ࣮ࣗࡢ࠺ࡕ 8 ࡘࢆ㑅ᐃࡋࠊࡑࢀࡽࢆձ࢚ࢿࣝࢠ࣮600~670kcalࠊ㣗ሷ┦ᙜ㔞 3.0g ᮍ‶ղ㔝⳯ 120㹥௨ୖ㸦⥳㯤Ⰽ㔝⳯ 40g ௨ୖ㸧ճ─ᩘ 5 ─௨ୖࠊࡇࡢ㸱ࡘࡢ᮲௳࡟ྜ࠺ࡼ࠺ヨసࢆ⧞ࡾ㏉ࡋࡓࠋ7 ᭶ 16 ᪥Ꮫෆࢥࣥࢸࢫࢺ࡛ࠊヨ㣗఍ࡢ㸰࣓ࢽ࣮ࣗࢆ㑅ᐃࡋࡓࠋࡲࡓࠊ㔝⳯ 70㹥௨ୖࡢ 16 ᩱ⌮ࢆᩱ⌮࣮࢝ࢻ࡜ࡋ࡚సᡂࡋࡓࠋ࠙⤖ᯝࠚヨ㣗఍࡟ཧຍࡋࡓ༊Ẹࡢពぢࡣࠊ࣓ࢽ࣮ࣗ౯᱁ 500 ෇ࡣࠊ29 ྡࠊ64.4%ࡀᏳ࠸࡜⟅࠼ࠊ࠾࠸ࡋ࠸ 41 ྡࠊ91.1㸣ࠊぢࡓ┠ࡀⰋ࠸ 44 ྡࠊ97.8㸣ࠊ㔝⳯ࡢ㔞ࡀࡕࡻ࠺࡝Ⰻ࠸ 34 ྡࠊ75.6㸣࡛࠶ࡗࡓࠋᏛ⏕ࡣࠊཧຍࡋ࡚࡜࡚ࡶ኱ኚࠊ኱ኚ19 ྡࠊ34.5㸣࡛࠶ࡗࡓࡀࠊཧຍࡋ࡚࡜࡚ࡶࡼ࠿ࡗࡓࠊࡼ࠿ࡗࡓ 33 ྡࠊ60.㸮㸣࡛࠶ࡗࡓࠋ࠙⪃ᐹࠚ༊Ẹ࠿ࡽࡶᏛ⏕࠿ࡽࡶࣉࣛࢫࡢពぢࡀከ࠿ࡗࡓࡀࠊ୍㒊ࠊ㈇ᢸ࡟ឤࡌࡓᏛ⏕ࡶぢࡽࢀࠊ௒ᚋࡢ㐍ࡵ᪉ࢆ᳨ウࡋࠊᏛ⏕ࡢᩍ⫱ຠᯝࢆ㧗ࡵ࡞ࡀࡽࠊᆅᇦ࡜ࡢ㐃ᦠࢆᅗࡗ࡚࠸ࡁࡓ࠸ࠋ-1-− 10 −෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏ⤥㣗⤒Ⴀ⟶⌮Ꮫ఍ ➨ 13 ᅇ኱఍኱㔞ㄪ⌮ᇶ♏ᐇ⩦ࡢ⤥㣗⤒Ⴀ⟶⌮ᐇ⩦࡜ࡢ⛉┠㛫㐃ᦠຠᯝࡢ᳨ウ㹼⊩❧సᡂㄢ㢟ࢆ㏻ࡌ࡚㹼ྜྷ⏣┿▱Ꮚ* ᰘ⏣㝯୍* బஂ㛫ಇᖾ* Ⲩ஭ࡋࡎ࠿** 㢼ぢබᏊ*㸨ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊  **⳹Ꮫᅬᰤ㣴ᑓ㛛Ꮫᰯせ᪨࠙┠ⓗࠚㄪ⌮Ꮫᐇ⩦࡛Ꮫࢇࡔ▱㆑࡜ᢏ⾡ࢆᇶ┙࡜ࡋ࡚ࠊ⤥㣗࡟ᑐᛂ࡛ࡁࡿ኱㔞ㄪ⌮ࡢᇶ♏ᢏ⾡ࢆ⩦ᚓࡋࠊ኱㔞ㄪ⌮సᴗࢆࢥ࣮ࢹ࢕ࢿ࣮ࢺ࡛ࡁࡿຊࢆ㣴࠺ࡇ࡜ࢆ┠ᶆ࡟ࠊᮏᏛ࡛ࡣ⤥㣗⤒Ⴀ⟶⌮ᐇ⩦ࡢᇶ♏⛉┠࡜ࡋ࡚኱㔞ㄪ⌮ᇶ♏ᐇ⩦ࡀ㓄ᙜࡉࢀ࡚࠸ࡿࠋᮏ◊✲࡛ࡣᤵᴗෆ࡛సᡂࡋࡓᏛ⏕⊩❧ࢆ㏻ࡋ࡚ᩍ⫱ຠᯝࢆ᳨ウࡍࡿࡇ࡜࡟ࡼࡾࠊ⤥㣗⤒Ⴀ⟶⌮ᐇ⩦࡬ࡢᇶ♏⛉┠࡛࠶ࡿᮏᩍ⛉ࡢ⛉┠㛫㐃ᦠຠᯝࡀᚓࡽࢀࡿ࠿ࢆ᳨ウࡍࡿࡇ࡜࡜ࡋࡓࠋ࠙᪉ἲࠚᖹᡂ  ᖺᗘ኱㔞ㄪ⌮ᇶ♏ᐇ⩦ࢆཷㅮࡋࡓᏛ⏕࡟ᤵᴗ㛤ጞ᫬࡜⤊஢᫬࡟ྠ୍᮲௳㸦᫨㣗 NFDOࠊ࿴㣗ࠊ୺㣗୺ᮦᩱ⡿ࠊ୺⳯୺ᮦᩱ㇜⫗ࠊㄪ⌮ἲ↻ࡿࠊ㣗ᮦᩱ㈝  ෇௨ෆ㸧࡛⊩❧ࢆసᡂࡉࡏࡓࠋ⮬ᕫホ౯࡜ඹ࡟ヨసࡢᩱ⌮෗┿ࢆῧ௜ࡉࡏࡓ⊩❧࠿ࡽᰤ㣴㔞ࠊᩱ⌮ࡢ⤌ࡳྜࢃࡏࠊᩱ⌮෗┿࠿ࡽⰍᩘ࡞࡝ࢆᢳฟࡋ᳨ウࢆ⾜ࡗࡓࠋ࠙⤖ᯝࠚ࢚ࢿࣝࢠ࣮࣭ࡓࢇࡥࡃ㉁࣭⬡㉁ࡣࠊᇶ‽್ෆ࡛సᡂࡋ࡚࠸ࡓࡀࠊᇶ‽್ࢆ♧ࡉ࡞࠿ࡗࡓ㣗ሷ┦ᙜ㔞ࡣࠊ㛤ጞ᫬⊩❧࡛ᖹᆒ 㹥࡜⤊஢᫬ࡢ 㹥ࢆ኱ᖜ࡟ୖᅇࡿ್࡜࡞ࡗࡓࠋᩱ⌮ࡢ⤌ࡳྜࢃࡏࡣࠊ୺㣗࣭୺࣭⳯๪⳯Ϩ࣭๪⳯ϩ࣭Ồ≀ࡀᥞࡗࡓࡶࡢࡀከ࠸ࡀࠊ኱㔞ㄪ⌮ࢆព㆑ࡋ┒ࡾ௜ࡅࡢᕤ⛬ࢆ༢⣧໬ࡍࡿᕤኵࡀࡳࡽࢀࡓࠋᩱ⌮෗┿ࡼࡾ㣗ᮦࡢⰍᩘࢆᢳฟࡋࡓ࡜ࡇࢁࠊ㛤ጞ᫬ࡢ⊩❧ࡢ  Ⰽ࠿ࡽ⤊஢᫬࡟ࡣ 㹼 Ⰽ࡜ᙬࡾࢆព㆑ࡍࡿ⊩❧ࡀቑຍࡋࡓࠋᏛ⏕࡟ࡼࡿ⊩❧ホ౯࡟࠾࠸࡚ࡶࠊᤵᴗࢆ㏻ࡌ࡚⮬ࡽㄢ㢟Ⓨぢࡋࠊ⤥㣗⤒Ⴀ⟶⌮ᐇ⩦࡬ྥࡅ࡚ࡢᏛ⩦ពḧࢆ㧗ࡵࡿグ㏙ࡀከࡃぢࡽࢀࡓࠋ࠙⪃ᐹࠚᮏ⛉┠࡛ᑡ㔞ㄪ⌮࠿ࡽ኱㔞ㄪ⌮ࢆព㆑ࡋࡓ⊩❧࡟⛣⾜ࡉࡏࡿࡇ࡜ࡣࠊ⤥㣗⤒Ⴀ⟶⌮ᐇ⩦࡛⩦ᚓࡍ࡭ࡁ⾨⏕⟶⌮ࡸே஦⟶⌮࡞࡝⥲ྜⓗ࣐ࢿࢪ࣓ࣥࢺ⬟ຊࡢ⫱ᡂ࡟ྥࡅࡓ⛉┠㛫ࡢ⧅ࡀࡾ࡟᭷ຠ࡛࠶ࡿ࡜⪃࠼ࡽࢀࡿࠋ− 11 −෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏ೺ᗣᏛ఍⥲఍ ➨ 82 ᅇ኱఍㣗 ⫱ ᣦ ᑟ ࡢ ࡓ ࡵ ࡢ ᗂ ⛶ ᅬ ඣ ཬ ࡧ ಖ ㆤ ⪅ ࡢ ⏕ ά ⩦ ័ ࡜ 㣗 ⩦ ័ ࡟ 㛵 ࡍ ࡿ ㄪ ᰝ㸫ಖㆤ⪅ࡀࡼࡃసࡿᩱ⌮࡜Ꮚ࡝ࡶࡢዲࡁ࣭᎘࠸࡞ᩱ⌮ࡢ㛵㐃㸫㢼ぢබᏊ 㕥ᮌ୕ᯞᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊 せ᪨࠙ࡣࡌࡵ࡟ࠚᗂඣࡢ㣗஦ࡢ⫼ᬒࡣࠊᗂඣࡢ㣗஦ࡢ኱㒊ศࢆ⟶⌮ࡍࡿಖㆤ⪅ࡢ㣗ព㆑ࡀ཯ᫎࡉࢀ࡚࠸ࡿ࡜⪃࠼ࡽࢀࠊಖㆤ⪅ࡢ㣗ព㆑ࡸ㣗⾜ື࡜ᗂඣࡢ㣗⾜ື࡜ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚ࡢ◊✲ࡀ࡞ࡉࢀ࡚࠸ࡿࠋᮾி⪷ᰤ኱Ꮫ㝃ᒓࢃࡓ࡞࡭ᗂ⛶ᅬ࡛ࡣࠊᖺࡼࡾࠊ᏶඲⤥㣗ࡀᐇ᪋ࡉࢀ࡚࠾ࡾࠊ⤥㣗࡟࠾࠸࡚ࡣࠊᐃホࡀ࠶ࡿࠋᅬඣ࡟ᑐࡍࡿ㣗⫱ࡶࠊᩍㅍࢆ୰ᚰ࡜ࡋࡓ⤥㣗᫬ࡢኌ᥃ࡅࡸࠊᅬ࡛ࡢ㔝⳯సࡾࠊࡑࢀࡽ㔝⳯ࢆษࡿ⦎⩦࡞࡝࡞ࡉࢀ࡚࠸ࡿࡀࠊ⌧≧ࠊ㣗⫱ࡢᑐ㇟ࡢከࡃࡣᗂඣ࡛࠶ࡾࠊಖㆤ⪅࡬ࡢാࡁ࠿ࡅࡣᑡ࡞࠸ࠋࡑࡢࡓࡵࠊᗂ⛶ᅬඣཬࡧಖㆤ⪅ࡢ⏕ά⩦័࡜㣗⩦័࡟ࡘ࠸࡚ࠊᐇែㄪᰝࢆࡋࠊᗂඣ࠾ࡼࡧಖㆤ⪅ࠊ୧⪅࡟ᑐࡍࡿ㣗⫱஦ᴗ࡟ࡘ࡞ࡆࡿᇶ♏㈨ᩱࢆᚓࡿࡇ࡜ࢆ┠ⓗ࡜ࡋࡓࠋᮏⓎ⾲࡛ࡣࠊಖㆤ⪅ࡀࡼࡃసࡿᩱ⌮࡜Ꮚ࡝ࡶࡢዲࡁ࡞ᩱ⌮ࠊᏊ࡝ࡶࡢ᎘࠸࡞ᩱ⌮ࡢ㛵㐃ᛶ࡟ࡘ࠸࡚㏙࡭ࡿࠋ࠙᪉ἲࠚ㸬ᑐ㇟⪅㸸㝃ᒓᗂ⛶ᅬಖㆤ⪅  ྡ㸬ㄪᰝᮇ㛫ཬࡧᅇ཰᪉ἲ㸸࢔ࣥࢣ࣮ࢺࢆᖹᡂ  ᖺ  ᭶  ᪥࡟㓄ᕸࠊᅇ཰ࡣࠊ ᭶  ᪥㹼 ᭶  ᪥࡟ᅬඣ㏦㏄ࣂࢫཪࡣᗂ⛶ᅬཷ௜❆ཱྀ࡟ᥦฟ࡜ࡋࡓࠋ㸬ㄪᰝෆᐜ㸸ᒓᛶࠊయㄪࠊᗂ⛶ᅬ⤥㣗࡟ࡘ࠸࡚ࠊᗂඣࡢዲࡁ᎘࠸ࠊᗂඣཬࡧಖㆤ⪅ࡢ㣗⩦័ࠊඹ㣗ࡢ᭷↓ࠊಖㆤ⪅ࡢᗂඣ࡟ᑐࡍࡿ㣗༟࡛ࡢࡋࡘࡅࠊಖㆤ⪅ࡢ㣗࡟ᑐࡍࡿ⪃࠼➼  㡯┠ࠋ࠙⤖ᯝࠚ㸬࢔ࣥࢣ࣮ࢺᅇ⟅⪅ཬࡧᏊ࡝ࡶࡢᒓᛶ࢔ࣥࢣ࣮ࢺࡢᅇ཰⋡ࡣ 㸣࡛࠶ࡗࡓࠋ࢔ࣥࢣ࣮ࢺᅇ⟅⪅ࡣࠊ㸣ࡀẕぶ࡛ࠊ ௦ࡀ 㸣ࠊ୺፬ࡀ 㸣࡛࠶ࡗࡓࠋᅬඣࡣ➨  Ꮚࡀ 㸣ࠊ ṓඣࢡࣛࢫࡀ 㸣࡜㧗࠿ࡗࡓࠋ㸬ಖㆤ⪅ࡀᐙᗞ࡛ࡼࡃసࡿᩱ⌮࣭Ꮚ࡝ࡶࡢዲࡁ࡞ᩱ⌮࣭Ꮚ࡝ࡶࡢ᎘࠸࡞ᩱ⌮⾲  ࡟ᐙᗞ࡛ࡼࡃసࡿᩱ⌮࡜Ꮚ࡝ࡶࡢዲࡁ࡞ᩱ⌮࡜᎘࠸࡞ᩱ⌮ࡢ࣋ࢫࢺ  ࢆ♧ࡋࡓࠋࡼࡃసࡿᩱ⌮ࠊᏊ࡝ࡶࡢዲࡁ࡞ᩱ⌮ඹ࡟  ఩ࡣ࣮࢝ࣞࣛ࢖ࢫ࡛࠶ࡗࡓࠋࡼࡃసࡿᩱ⌮ࡢ୰࡟ࡣࠊ࣮࢝ࣞࣛ࢖ࢫࡸ↝ࡁ㨶ࡢࡼ࠺࡟Ꮚ࡝ࡶࡢዲࡁ࡞ᩱ⌮࡟ࡶࠊ᎘࠸࡞ᩱ⌮࡟ࡶ࡞ࡾᚓࡿࡇ࡜ࡀ♧၀ࡉࢀࡓࠋᏊ࡝ࡶࡢ᎘࠸࡞ᩱ⌮࡟᎘࠸࡞ᩱ⌮ࡣ࡞ࡋ࡜⟅࠼ࡓ⪅ࡣࠊ㸣࡛࠶ࡗࡓࠋ᎘࠸࡞ᩱ⌮ࡣ㔝⳯ࢆ୺ᮦᩱ࡜ࡍࡿᩱ⌮ࡀከ࠿ࡗࡓࠋ㸬ලධࡾ୺㣗ࡢฟ⌧⋡ ලධࡾ୺㣗㸦୺㣗࡟࿡ࡀࡘ࠸࡚࠸࡚௦⾲ⓗ࡞ᩱ⌮࡜ࡋ࡚ࡣࠊ࣮࢝ࣞࣛ࢖ࢫࠊࢳ࣮ࣕࣁࣥࠊࢫࣃࢤࢵࢸ࢕ࠊࡩࡾ࠿ࡅࡈ㣤➼㸧ࡣࠊࡑࢀࡔࡅ࡛㣗࡭ࡽࢀࡿࡢ࡛ࠊ୺㣗࣭୺࣭⳯๪⳯ࡀᥞ࠸࡟ࡃ࠸࡜ゝࢃࢀ࡚࠸ࡿ୺㣗࡛࠶ࡿࡀࠊᐙᗞ࡛ࡼࡃసࡿᩱ⌮࡛ࡣࠊ㸣ࠊᏊ࡝ࡶࡢዲࡁ࡞ᩱ⌮࡛ࡣ 㸣ࡢฟ⌧⋡࡛࠶ࡗࡓࠋ− 12 −࿴ᩥࡢሙྜࡣMS ᫂ᮅ 10 ࣏࢖ࣥࢺ࡟ࡍࡿࠋ㸦10 ⾜௨ෆ㸧‫ڧڧڧڧڧڧڧڧڧڧڧڧڧڧڧڧڧڧڧڧ‬⾲ 1 ᐙᗞ࡛ࡼࡃసࡿᩱ⌮ࠊᏊ࡝ࡶࡢዲࡁ࡞ᩱ⌮ࠊᏊ࡝ࡶࡢ᎘࠸࡞ᩱ⌮࣋ࢫࢺ10ᐙᗞ䛷䜘䛟స䜛ᩱ⌮Ꮚ䛹䜒䛾ዲ䛝䛺ᩱ⌮㡰఩ᩱ⌮ྡ࣮࢝ࣞࣛ࢖ࢫ↝ࡁ㨶ࣁࣥࣂ࣮ࢢ၈ᥭࡆ㔝⳯ࡢ↻≀㘠Q㡰఩ᩱ⌮ྡ ࣮࢝ࣞࣛ࢖ࢫQᏊ䛹䜒䛾᎘䛔䛺ᩱ⌮ᩱ⌮ྡ㡰఩㻝᎘䛔䛺䛧Qࣁࣥࣂ࣮ࢢ

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[Method] We delivered the nutrition instruction to two sets of students: male students of an average of 16 who were members ofa high school long-distance relay running club, and female students of an average age of 18 who were members of a universityvolleyball club. The students received two rounds of group instruction followed by one round of individual instruction.
[Results] Where the energy intake goal was 3,315 kcal, we observed cases of inadequate intake (2,896 ± 634.7 kcal).
Accordingly, for the group instruction, we focused on conveying the necessity of a balanced diet, dietary coping strategies foranemia, and the use of convenience stores. For the individual instruction, we focused on the kinds of foods the student inquestion should consume, and quantities thereof, to make up for inadequate intake. Among the male students, 35 ± 19.8% hadnever received such instruction before and 87.4% reported that the instruction had motivated them to make dietaryimprovements. Similar results were obtained for the female students.
[Conclusion] The existing style of nutrition instruction is almost adequate, but there should be better-tailored instructionsmatching the lifestyles of the learners.

− 14 −෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲᪥ᮏᰤ㣴࣭㣗⣊Ꮫ఍ ➨ 71 ᅇ኱఍㣬࿴ࠊࡲࡓࡣ୍౯୙㣬࿴⬡⫫㓟ࡢᦤྲྀࡀ࢚ࢿࣝࢠ࣮௦ㅰࡢኚ໬࡜⏕యࣜࢬ࣒࡟୚࠼ࡿᙳ㡪▮ᓥඞᙪ* ຍᰘࡢࡒࡳ** 㧗ᮌㅬ** ⥴ᙧࡦ࡜ࡳ** ⴛሙ᱈Ꮚ*** బ⸨ㄔ*** ᚨᒣ⸅ᖹ**㸨ᮾி⪷ᰤ኱Ꮫ೺ᗣᰤ㣴Ꮫ㒊  **⟃Ἴ኱Ꮫே㛫⥲ྜ⛉Ꮫ◊✲⛉ ***⟃Ἴ኱Ꮫᅜ㝿⤫ྜ╧╀་⛉Ꮫ◊✲ᶵᵓせ᪨ ࢚ࢿࣝࢠ࣮௦ㅰ࡜╧╀ࡣࠊከࡃࡢ⏕యෆศᏊᶵᵓࢆඹ᭷ࡋ࡚࠸ࡿࠋ᪤࡟ື≀ᐇ㦂࡛ࡣࠊ㧗⬡⫫㣗ࡢᦤྲྀ࡟ࡼࡗ࡚╧╀ࢆྵࡴ⏕యࣜࢬ࣒ࡢ㐜ᘏࡀ㉳ࡇࡿࡇ࡜ࡀሗ࿌ࡉࢀ࡚࠾ࡾࠊࡑࡢཎᅉࡀ㣬࿴⬡⫫㓟ࡢከ㔞ᦤྲྀ࡟ࡼࡿ࡜⪃ᐹࡉࢀ࡚࠸ࡿࠋࡑࡇ࡛ᡃࠎࡣࣄࢺࢆᑐ㇟࡜ࡋࠊ⬡⫫㓟⤌ᡂࡢ␗࡞ࡿヨ㦂㣗ࡢᦤྲྀ࡟ࡼࡿᙳ㡪ࢆ᫂ࡽ࠿࡟ࡍࡿࡓࡵࠊ࢚ࢿࣝࢠ࣮௦ㅰ࠾ࡼࡧ⏕యࣜࢬ࣒㸦╧╀᫬⬻Ἴࠊ᫬ィ㑇ఏᏊⓎ⌧࠾ࡼࡧ῝㒊య 㸧ࢆ඲࡚ྠ୍ࡢᐇ㦂࡛ホ౯ࡍࡿࠊᅜෆ࣭እ࡛ึࡢ◊✲ࢆヨࡳࡓࠋ10 ேࡢⱝᖺᡂே⏨ᛶࢆ⿕㦂⪅࡜ࡋࠊ㸰ヨ⾜ࡢࢡࣟࢫ࣮࢜ࣂ࣮ヨ㦂ࢆᐇ᪋ࡋࡓࠋ⿕㦂⪅ࡣ high-oleic acid diet(HOAD: 57.6% as oleic, 7.8% as palmitic acid)ࡲࡓࡣ high-palmitic acid diet (HPAD: 37.6% as palmitic, 41.6% asoleic acid)ࢆ㸱㣗ᦤྲྀࡋࠊ࢚ࢿࣝࢠ࣮௦ㅰ࠾ࡼࡧ῝㒊య ࢆ ᐃࡋࡓࠋ╧╀᫬⬻Ἴࡣኪ㛫ࡢ㸶᫬㛫 ᐃࡋࠊ23 ᫬㛫ẖ࡟ྜィ㸶ᅇ⾑ᾮࢧࣥࣉࣝࢆ᥇ྲྀࡋ᫬ィ㑇ఏᏊⓎ⌧ࢆゎᯒࡋࡓࠋ࢚ࢿࣝࢠ࣮௦ㅰࡣ HPAD ⩌࡜ẚ㍑ࡋࠊHOAD ⩌࡛⬡㉁㓟໬㔞ࡀቑ኱ࡋࡓࠋ᪥ෆኚືࢆࡋ࡚࠸ࡿ⏕యࣜࢬ࣒ࡢᣦᶆࡣࠊHPAD ⩌࡛᣺ᖜࡀቑ኱ࡋ㡬Ⅼ఩┦ࡀ㐜ᘏࡋࡓࠋ╧╀᫬⬻ἼࡣࠊHOAD ⩌࡛╧╀๓༙ࡢ῝╧╀㔞ࡀቑ኱ࡋࡓࠋᮏ⤖ᯝࡼࡾࠊ㐣๫࡞㣬࿴⬡⫫㓟ᦤྲྀࡣ࢚ࢿࣝࢠ࣮௦ㅰ࡬ࡢᝏ
ᙳ㡪ࢆ௓ࡋ࡚⫧‶ࢆᘬࡁ㉳ࡇࡍࡇ࡜࡟ຍ࠼࡚ࠊ⏕యࣜࢬ࣒ࡢ஘ࢀ࡟ࡼࡿ⏕ά⩦័⑓ࢆㄏⓎࡍࡿྍ⬟ᛶࡀ♧၀ࡉࢀࡓࠋ− 15 −෌㘓 ࣏ࢫࢱ࣮Ⓨ⾲Recent Advances and Controversies in Measurement of Energy Metabolism 4th international conferenceEffects of meal rich in monounsaturated or saturated fatty acid on energy metabolismand biological rhythmKatsuhiko Yajima* Nozomi Kashiba** Ken Takagi ** Momoko Kayaba***** HitomiOgata**** Insung Park*** Yoshiaki Tanaka ** Makoto Sato *** Kumpei Tokuyama **Department of Administrative Nutrition, Faculty of Health and Nutrition, Tokyo Seiei College㸨Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba

㸨㸨International Institute for Integrative Sleep Medicine, University of Tsukuba

㸨㸨㸨HIROSHIMA UNIVERSITY, Graduate School of Integrated Arts and Sciences㸨㸨㸨㸨Department of Somnology, Tokyo Medical University㸨㸨㸨㸨㸨

せ᪨Energy metabolism is regulated by the clock through daily cycles of feed-fast, sleep-wake and body temperature cycles. High-fatmeals, in particular saturated acid, delays circadian rhythm in mice. Aim of the present study was to examine acute effects ofmonounsaturated (oleic acid) and saturated (palmitic acid) dietary fats on diurnal variation in energy metabolism, core bodytemperature and clock gene expression and sleep in human. The study was a randomized single-blinded repeated measuresdesign. Ten males participated two sessions of indirect calorimetry in a whole-room calorimeter. In each session, subjectsconsumed the meal based on safflower oil or meal based on palm oil in three meals. Sleep electroencephalogram was measuredduring nighttime and blood sampling was collected at 8 time points during 24 h indirect calorimetry to assess clock geneexpression in leukocyte. Compared with meal rich in saturated fatty acid, consumption of high monounsaturated fatty acid mealinduced the followings; 1) Fat oxidation was significantly enhanced throughout the day, 2) Core body temperature was loweredin the evening and the first half of the sleep (from 19:00 to 2:00), 3) Slow wave sleep was significantly increased in the first sleepcycle. High intake of saturated fatty acids may be a risk factor of obesity through circadian misaligment and inhibit fat oxidation.

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ࢆ⏝࠸࡚ZRUG࡛సᡂࡋࡓ༳Ꮠཎ✏࡟ࠊ㟁Ꮚࣇ࢓࢖ࣝࢆῧ࠼࡚⣖せ⦅㞟ጤဨ఍௨ୗࠊጤဨ఍࡜࠸࠺ࠋ ࡟ᥦฟࡍࡿࠋ
㸰㸬ࢸࣥࣉ࣮ࣞࢺࡣᮏ⣖せ࣮࣒࣮࣍࣌ࢪ࠿ࡽධᡭࡍࡿࡇ࡜ࠋࢸࣥࣉ࣮ࣞࢺࡣཎ✏సᡂୖࡢὀព᭩ࡁ࡟࡞ࡗ࡚࠸ࡿࡢ࡛ཎ✏సᡂ๓࡟Ⰻࡃㄞࡴࡇ࡜ࠋ   㸦ཎ✏ࡢᇳ➹せ㡿㸧         㸱㸬ཎ✏ࡢ᭩ᘧࡣ࿴ᩥࡢሙྜࡣࠊᏐ⾜ẁࢆ㸯࣮࣌ࢪ࡜ࡍࡿࠋḢᩥཎ✏࡛ࡣFP⾜ẁࢆ㸯࣮࣌ࢪ࡜ࡍࡿࠋ 㸲㸬ᮏᩥࡢ๓࡟ㄽᩥ㢟ྡࠊⴭ⪅ྡࠊ࢔ࣈࢫࢺࣛࢡࢺࠊ㸦ཎ✏ཷ௜᪥ࠊཎ✏ཷ⌮᪥㸧           ࢆグධࡍࡿࠋ㸳㸬࢔ࣈࢫࢺࣛࢡࢺࡣⱥᩥ࡜ࡍࡿࠋ㸴㸬ᮏᩥࡣ᫂ᮅయ࡜ࡋࠊ⥴ゝࠊᐇ㦂᪉ἲࠊᐇ㦂⤖ᯝࠊ⪃ᐹ㸦ᐇ㦂⤖ᯝ࡜⪃ᐹࡣྠࡌ㡯┠࡜ࡋ࡚ࡶⰋ࠸㸧ࠊせ⣙ࠊཧ⪃ᩥ⊩ࡢ㡰࡟グ㏙ࡍࡿࠋ㸵㸬ཧ⪃ᩥ⊩ࡣ࢔ࣈࢫࢺࣛࢡࢺࠊᮏᩥࢆ㏻ࡋࠊグ㍕㡰࡟␒ྕࢆࡩࡾࠊᚲせ࡜ࡍࡿ⟠ᡤࡢ⫪࡟࢔ࣛࣅ࢔ᩘᏐࢆ∦࢝ࢵࢥࢆࡘࡅ࡚グධࡍࡿࠋ㸶㸬➨㸯࣮࣌ࢪ┠ࡢୗ㒊࡟ࡣ࣮࣮࢟࣡ࢻࢆ㸳ㄒ⛬ᗘグධࡍࡿࠋ㸷㸬❶ࠊ⠇ࡣࢦࢩࢵࢡయ࡜ࡋࠊ௨ୗࡢࡼ࠺࡟グࡍࡇ࡜࡜ࡍࡿࠋ኱ぢฟࡋࡣ 㸯㸬㸰㸬㸱㸬࣭࣭࣭࣭࣭࣭࣭୰ぢฟࡋࡣ      ࣭࣭࣭࣭࣭࣭࣭ᑠぢฟࡋࡣ       ࣭࣭࣭࣭࣭࣭࣭࣭࣭

ᑠぢฟࡋ࡟ࡉࡽ࡟㡯ࢆタࡅࡿሙྜ࡟ࡣ        ࣭࣭࣭࣭࣭࣭

ࡘࡂࡣ࢔ࣝࣇ࢓࣋ࢵࢺ࡛ࠊD   E   F ࣭࣭࣭࣭࣭࣭࣭࣭

㸬ⱥᩥࡢሙྜࡣࠊ኱ぢฟࡋࡣྛ༢ㄒࡢ㢌ᩥᏐࢆ኱ᩥᏐ࡜ࡋࠊ୰ぢฟࡋ௨ୗࡣ➨㸯ᩥᏐࡢࡳ኱ᩥᏐ࡜ࡍࡿࠋ
㸬ᅗࠊ⾲ࠊ෗┿ࡣⱥᩥ⾲グ࡜ࡋᮏᩥ୰࡟⤌ࡳ㎸ࡳࠊ)LJXUHࠊ 7DEOHࠊ3KRWRࡢࡼ࠺࡟ᅗ⾲␒ྕࢆグࡋࠊ࣮࣎ࣝࢻయ࡜ࡍࡿࠋ㸬ཧ⪃ᩥ⊩ࡣᮏᩥᮎ࡟ࡲ࡜ࡵ࡚ᥖ㍕ࡍࡿࠋグ㍕ࡣࠊⴭ⪅ྡࠊㄽᩥྡࠊ㞧ㄅྡࠊᕳࠊྕࠊ࣮࣌ࢪ㸦᭱ึ࡜⤊ࢃࡾ㸧ࠊⓎ⾜ᖺࡢ㡰࡜ࡍࡿࠋᡂ᭩ࡢሙྜࡣⴭ⪅ྡࠊ᭩ྡࠊᘬ⏝࣮࣌ࢪࠊฟ∧♫ྡࠊⓎ⾜ᖺࡢ㡰࡟グ㍕ࡍࡿࠋ − 18 −ிʮᎢ௿‫ܖٻ‬ኔᙲ‫ݙ‬௹ؕแ 㸦ᑂᰝࡢᑐ㇟㸧          㸯㸬ᑂᰝࡢᑐ㇟࡜ࡍࡿཎ✏ࡣᮾி⪷ᰤ኱Ꮫᢞ✏せ㡿㸰࡟ᐃࡵࡿཎⴭㄽᩥࠊ▷ሗࠊ࠾ࡼࡧ㈨ᩱ࡜ࡍࡿࠋ㸦ᰝㄞ⪅㸧㸰㸬ᰝㄞ⪅ࡣ㸰ྡ௨ୖ࡜ࡋࠊᏛෆእ࠿ࡽ⣖せ⦅㞟ጤဨ఍ ௨ୗࠊጤဨ఍࡜࠸࠺ࠋ ࡟ࡼࡗ࡚㑅ฟࡉࢀࡿࠋ㸱㸬ㄽᩥࡢෆᐜ࣭⾲⌧ࡣࡍ࡭࡚ᇳ➹⪅ࡀ㈐ࢆ㈇࠺ࡶࡢ࡜ࡍࡿࠋ㸲㸬ᰝㄞ⪅ࡢྡࡣᇳ➹⪅࡟⛎ࡍࡶࡢ࡜ࡍࡿࠋ㸦ᑂᰝࡢ᪉ἲ㸧                          㸳㸬ᰝㄞ⪅ࡣᑂᰝ⤖ᯝࢆ௨ୗࡢࡼ࠺࡟ุᐃࡋࠊᑂᰝ⏝⣬࡟ࠊಟṇせồࠊཧ⪃ពぢ➼ࢆῧ࠼࡚ጤဨ఍࡟㏉㏦ࡍࡿࠋ 㹟㸧↓ಟṇ࡛ᥖ㍕ྍ 㹠㸧ಟṇᚋ࡟ᥖ㍕ྍ  㹡㸧ಟṇᚋ࡟෌ᑂᰝ  㹢㸧ᥖ㍕୙ྍ 㸴㸬↓ಟṇ࡛ᥖ㍕ྍ࡜ุᐃࡉࢀࡓཎ✏࡟ࡘ࠸࡚ࡣࠊᑂᰝホࢆ☜ㄆࡋ࡚ጤဨ఍ࡀ᭱⤊ⓗ࡟ᥖ㍕ࢆỴᐃࡍࡿࠋ
㸵㸬ಟṇᚋᥖ㍕ྍ࡜ุᐃࡉࢀࡓཎ✏࡟ࡘ࠸࡚ࡣࠊጤဨ఍ࡀᰝㄞ⪅࡟௦ࢃࡗ࡚ಟṇ㒊ศࢆ☜ㄆࡋࠊಟṇࡀ༑ศ࡟࡞ࡉࢀ࡚࠸ࡿ࡜ุ᩿ࡋࡓሙྜࡣᥖ㍕ࢆỴᐃ࡛ࡁࡿࠋಟṇࡀ୙༑ศ࡜ุ᩿ࡋࡓሙྜࡣᇳ➹⪅࡟ಟṇࢆồࡵࡿ࠿ࠊᰝㄞ⪅࡟෌ᑂᰝࢆせㄳࡍࡿࡇ࡜ࡀ࡛ࡁࡿࠋ㸶㸬ᰝㄞ⪅ࡀཎ✏ࡢಟṇࡀᚲせ࡜ุ᩿ࡋࡓሙྜࠊ࠾ࡼࡧᥖ㍕୙ྍ࡜ุ᩿ࡋࡓሙྜࡣጤဨ఍ࡣᑂᰝホࢆῧ௜ࡋ࡚ࠊཎ✏ࢆᇳ➹⪅࡟㏉༷ࡍࡿࠋ㸷㸬ಟṇᚋ࡟෌ᑂᰝ࡜ุᐃࡉࢀࡓሙྜࠊಟṇᚋࡢ෌ᑂᰝࡣࠊཎ๎࡜ࡋ࡚ࠊᙜึ㑅௵ࡉࢀࡓᰝㄞ⪅ࡀࡇࢀ࡟ᙜࡓࡿࡶࡢ࡜ࡍࡿࠋ㸬ཎⴭㄽᩥ࡜ࡋ࡚ᢞ✏ࡉࢀࡓࡶࡢ࡛ࠊᰝㄞ⪅ࡀࠊෆᐜࡀཎⴭㄽᩥ࡜ࡋ࡚ࡢᇶ‽࡟ࡣ㐩ࡋ࡚࠸࡞࠸ࡀ▷ሗ࡜ࡋ࡚ࡢ౯್ࡀ࠶ࡿ࡜ุ᩿ࡋࡓሙྜࡣࠊᑂᰝ⏝⣬࡟ࡑࡢ᪨ࢆ᫂グࡋࠊጤဨ఍࡟ሗ࿌ࡍࡿࠋ− 19 −