East Asia Regional Biometric Conference 2007

A picture --- Japanese Garden

EAR-BC 2007
Final Announcement
9-11 December 2007
University of Tokyo, Japan
wwwsoc.nii.ac.jp/jbs/index_e.html

EAR-BC'07 Tokyo Japan Final Conference Program December 2007
Sunday 9

Monday 10

Tuesday 11

08:30-17:00
Registration

08:30-17:00
Registration

08:30-11:00
Registration

09:00-10:30
Opening Ceremony

09:00-10:30
Invited Session:
Bioinformatics

09:00-10:30
Contributed Session:
Biostatistics in General

10:30-11:00
Coffee Break

10:30-11:00
Coffee Break

10:30-11:00
Coffee Break

11:00-12:30
Invited Session:
Clinical Trials

11:00-12:00
Keynote Lecture

11:00-12:30
Contributed Session:
Clinical Trails 2

08:55-09:00
Opening Address

12:30-14:00
Lunch
14:00-15:30
Contributed Session:
Epidemiology
15:30-16:00
Coffee Break
16:00-17:30
Contributed Session:
Bioinformatics

12:00-13:30
Lunch

12:30-12:35
Closing Remarks

13:30-15:00
Invited Session:
Epidemiology
15:00-15:30
Coffee Break
15:30-17:00
Contributed Session:
Clinical Trials 1

13:30-17:30
Domestic Meeting
Biometric Seminar:
Global Clinical Trials(Sponsored by JBS)

17:30-20:00
Conference dinner(During the day)
Poster Session(During the day)
Poster Session

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Welcome
On behalf of the Organizing and Scientific
Programme Committee, it is a great pleasure
to invite you to attend the first Regional
Conference of East Asia Regions of theInternational Biometric Society. It will bringparticipants from East Asia Regions working
in academic institutions, regulatory agencies,
and industry together to present new
research on the latest advances in biometry,biostatistics and bioinformatics. One of theaim of the conference is to allow
participants from East Asia countries as well
as different parts of the world to exchange
ideas and to establish long-term
collaborative relationships. These sessions
included prominent representatives from a
range of different disciplines in these fields.
Three-day conference includes invited
sessions, contributed sessions and poster
presentations.
In December, Tokyo is usually sunny but
somewhat cold. The winter nights arealways illuminated with Christmas display.
We hope you enjoy staying in Tokyo andalso a plenty of the intellectual
conversations at conference.

Conference Website
http://wwwsoc.nii.ac.jp/jbs/index_e.html

Organizing and Scientific
Programme Committee
Chair Toshiro Tango, National Institute of
Public Health (Japan)
Secretary Kazue Yamaoka, National
Institute of Public Health (Japan)
Treasurer Chikuma Hamada, Tokyo
University of Science (Japan)

Scientific Programme Chair Tosiya Sato,
Kyoto University (Japan)
Members
Manabu Iwasaki, Seikei University (Japan)
Hirohisa Kishino, University of Tokyo(Japan)Masaaki Matsuura, Japanese Foundation forCancer Research (Japan)
Yutaka Matsuyama, University of Tokyo(Japan)Mihoko Minami, Institute of Statistical
Mathematics (Japan)
Toshihiko Morikawa, Kurume University(Japan)Yasuo Ohashi, University of Tokyo (Japan)
Hironori Sakai, Mitsubishi Pharma
Corporation (Japan)
Hiroyuki Uesaka, Lilly ResearchLaboratories Japan (Japan)
Takashi Yanagawa, Kurume University(Japan)Thomas Louis, IBS President, Johns
Hopkins University (USA)Ashwini Mathur, IBS General Secretary,
Novartis International ClinicalDevelopment Center (India)
Taerim Lee, Korean Region President,
National Open University (Korea)
Seungho Kang, Korean Region Secretary,
Ewha Women's University (Korea)
Byung Soo Kim, Yonsei University (Korea)
H. Sridhara, Indian Region President,
University of Agricultural Sciences(India)Ji-Qian Fang, National Group China
Secretary, SunYat-Sen University of
Medical Science (China)
Ayanendranath Basu, Indian Statistical
Institute (India)

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Registration

Accommodation

To avoid difficulties and troubles regarding
payment of registration fee, On-site payment
only is acceptable at the registration desk
during the EAR-BC’07. Payment for all
registration fees should be made in Japaneseyen (cash only) as follows:

In the vicinity of the conference site, a wide
range of hotel accommodation is available
and a list of less expensive hotels is listed
together with a room rate (single room) as
below. However, we strongly recommendthat speakers from foreign countries stay atTokyo Dome Hotel for convenience.

・Registration fee
Industry:
JPY
30,000yen
Academic: JPY
10,000yenStudent:
JPY
5,000yen
Attendants from Asian countries otherthan Japan JPY
5,000yenRegistration is available only by E-mail. If
your industry have already registered as acorporate member, it is not necessary to
conduct E-mail registration. You can register
the EAR-BC’07 by sending E-mail with title“Registration on EAR-BC’07” including thefollowing information tobiometrics@sinfonica.or.jp .
Required information for the registration
Registration Type:(Industry/Academic/Student/Attendants
from Asian countries)
Title: (Mr. / Ms. / Dr. / Prof), Name(First Name/Last Name)
Institute/Organization:
Department/Division:
Address/Country:
Postal code:
E-mail:Please type your E-mail address very
carefully. The deadline for the registration is
30 November 2007. If you have any
questions on the registration, please send an
E-mail to the address
hamada@ms.kagu.tus.ac.jp.

・Tokyo Dome Hotel: 15200 yenhttp://www.tokyodome-hotels.co.jp/e/
HP in Chinese and Korean language isavailable
・Forest Hongo: 10164yenhttp://www.forest-hongo.com/English/Hot
elInformation.htm
・Hotel Kizankan: 7350yenhttp://www4.ocn.ne.jp/~kizanweb/
・Tokyo Garden Palace: 9702yenhttp://www.hotelgp-tokyo.com/(Japanese only)
Address 1-7-5 Yushima, Bunkyo-ku,
Tokyo, 113-0034 Tel +81 (0)3 3813 6211
Fax +81 (0)3 3818 6060
・HOTEL OCHANOMIZU INN: 7980yenhttp://www.o-inn.co.jp/english_index.htm
・Tokyo Green Hotel Ochanomizu:
8400yenhttp://www.greenhotel.co.jp/en/hotel_list/
ochanomizu.html

・Japanese style Inn
SAWANOYA RYOKAN: 4935 yenhttp://www.tctv.ne.jp/members/sawanoya/

General Information
Conference Secretariat
Yoko Nezu
E-mail: yokon@niph.go.jp
Department of Technology Assessment andBiostatistics, National Institute of Public
Health,2-3-6Minami,Wako-shi,
Saitama-ken, 351-0197, Japan
Tel:+81 48 458 6223, Fax:+81 48 469 3875

Important Social Programme
Conference Dinner will take place at CapoPELLICANO on Monday 10 17:30-20:00(Med. Experimental Research Bldg. 13F)
Website:http://www.u-tokyo.ac.jp/campusmap/restau
rantmap.pdf (Restaurant No.21)
With a lot of atmosphere of Edo era,
“MOTI- TUKI” (a rice cake making show)

Registration Office
Chikuma Hamada
Treasurer, Organizing and Scientific
Programme Committee
E-mail: hamada@ms.kagu.tus.ac.jp
Faculty of Engineering, Tokyo University of
Science, 1-3 Kagurazaka, Shinjuku-ku,
Tokyo 162-8601, Japan
Tel:+81 35 228 8712, Fax:+81 35 213 1341
Scientific Communication
Tosiya Sato
Scientific Programme Chair, Organizing andScientific Programme Committee
E-mail: shun@pbh.med.kyoto-u.ac.jp
Department of Biostatistics, Kyoto
University School of Public Health, Yoshida
Konoe-cho, Sakyo-ku, Kyoto, Japan

will be presented by “IWAI-GUMI”. The“IWAI- GUMI” is a performance group of arice cake making show with dressing-up
costume of “MATOI” (a fireman's standard)and “SISI- GASIRA” (a lion mask).
MOTI-TUKI is Japanese traditional and oneof the most familiar celebratory occasion
wishing happiness, health, and welfare.
Please take part with your family and friends.
LET’S ENJOY!
Fee
JPY

5,000yen

Conference Venue
The University of Tokyo Yayoi Auditorium
Ichijo Hall, Department of Agriculture,
University of Tokyo, 1-1-1 Yayoi, Bunkyoku, Tokyo, 113-8657, Japan
Tel. +81 3 5841 8205
Website:http://www.a.u-tokyo.ac.jp/yayoi/index.html

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Official Language
The official Language of the Conference
will be English. Simultaneous translation
will not be provided.
Name Badges
All participants and accompanying persons
must wear the Congress identification badge
in a visible place. Entrance to meeting hall,poster and exhibition areas will not be
permitted to any person without badge.
Visual Equipment
The meeting hall will be equipped withoverhead and data projectors as well as PC
Letter of Invitation
The Conference Secretariat will be pleased
to provide you with an official letter ofinvitation. Please note that such letters
cannot grant any financial support. Requests
should include participant's full mailingaddress and fax number for reply. Inquiries
can be sent to the Conference Secretariat.
Liability and Insurance
The organizers have no responsibility
whatsoever for injury or damage involving
persons and property during the Congress.
Participants are advised to carry their own
personal insurance during their stay inJapan.

for speakers needs. Speakers are kindly
requested to check and deliver theirpresentation to visual reception at least one
hour before scheduled presentation. Due tochanges in computer configuration, laptops
will not be accommodated.
Traveling, Passport, Visa
All foreign visitors entering Japan mustpossess valid passports. Visa is not required
from citizens of most foreign countries.
Participants should check with travel agentsor diplomatic missions in their own
countries, whether of not visa is required.

Banks & Currency
Most banks are open Monday to Friday from
9:00am to 3.00pm.
Climate and Clothing
In December the weather is cold during thewhole day, so for all outdoor events, a coator a light sweater will be sometimes useful.
Mean temperature ranges from 5-13 C.
Tipping
For taxi and restaurants the service charge isincluded in the price. You may add a tip atyour own discretion to indicate appreciationof exceptionally good service.

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Scientific Program
Sunday, December 9, 2007 8:55-17:00
8:30-17:00 Conference registration
8:30
8:55-9:00
9:00-10:30

10:30-11:00
11:00-12:30

12:30-14:00
14:00-15:30

15:30-16:00

OPEN Registration
Opening Address: Toshiro Tango, Japanese Region President
Opening Ceremony: Introduction to IBS and its regional activities
Chair: Ashwini Mathur (the IBS General Secretary, Indian Region)
Thomas Louis (the IBS President, ENAR) “Our Future as History”
Jiqian Fang (National Group China Secretary) “Outcome Measurement for
TCM and Challenge to Statistics”
H. Sridhara (Indian Region President) “Sixty years of IBS (IR) and future of
Biometry in India”
Taerim Lee (Korean Region President) “Web Based Biostatistics Education
Hub for East Asian Region”
Toshiro Tango (Japanese Region President) “Major Activities of BiometricSociety of Japan and Japanese Biostatisticians: Past, Present and Future”
Coffee BreakInvited Session: Clinical Trials
Chair. Shigeyuki Matsui (Kyoto University School of Public Health, Japan)
Yuantao Hao (Sun Yat-sen University, China), Jiqian Fang, Xinyuan Song
“Non-linear Factor Analysis Model and its Application to Evaluating theEquivalence of Questionnaires”
Satoshi Morita (Kyoto University Hospital, Japan) “Determining theEffective Sample Size of a Parametric Prior”
Masako Nishikawa (National Institute of Public Health, Japan), Toshiro
Tango, Megu Ohtaki “Simple Statistical Tests for New Composite
Hypotheses in Randomized Clinical Trial Reflecting the Relative Clinical
Importance”
Lunch BreakContributed Session: Epidemiology
Chair: Yutaka Matsuyama (University of Tokyo, Japan)
Ya Fang (University of Xiamen, China) “Probability Prediction in Multistate
Survival Models for Patients with Chronic Myeloid Leukaemia”
Sachiko Tanaka (Tokyo University of Science, Japan) “Inverse Probability
Weighted Estimators in the Stratified Nested Case-Control Sampling
Methods”
Koji Yonemoto (Kyushu University, Japan), Atsushi Kawaguchi, Yumihiro
Tanizaki, Yutaka Kiyohara, Takashi Yanagawa, Young K. Truong“Application of Functional ANOVA Models for Hazard Regression to the
Hisayama Data”
Shizue Izumi (Oita University, Japan), Yoshinori Fujii “Estimating the Powerof the Likelihood Ratio Test in the Cohort-Based Nested Case-Control
Studies”
Coffee BreakPage 7

16:00-17:30

Contributed Session: Bioinformatics
Chair: Seiya Imoto (University of Tokyo, Japan)
Tomonori Oura (Kyoto University School of Public Health, Japan),
Shigeyuki Matsui, Koji Kawakami “Sample Size Calculations Based on
Exact Distribution of False Discovery Proportion in Microarray
Experiments”
Akihiro Hirakawa (Pharmaceuticals and Medical Devices Agency, Japan),
Yasunori Sato, Chikuma Hamada, Isao Yoshimura “A Test Statistic Based on
Shrunken Sample Variance for Identifying Differentially Expressed Genes in
Microarray Data Analysis”
Yoichi M. Ito (University of Tokyo, Japan), Yasuo Ohashi “Measurement
Scale Categorization and Its Resolution. A Gene Reduction Approach to theMicroarray Data Analysis”
Takeharu Yamanaka (National Kyushu Cancer Center, Japan), Shigeyuki
Matsui “Survival Prediction Using Top Ranking Significant Genes in Cancer
Prognostic Studies with Microarrays”
Mira Park (Eulji University, Korea), Yoo-Jin Jang, Myung-Hoe Huh“Applications of Minimal Spanning Tree and Self-Organizing Map in
Microarray Data Analysis”

Monday, December 10, 2007 8:55-17:00
8:30-17:00 Conference registration
9:00-10:30

10:30-11:00
11:00-12:00

12:00-13:30
13:30-15:00

Invited Session: Bioinformatics
Chair: Masaaki Matsuura (Japanese Foundation for Cancer Research,
Japan)Jae Won Lee (Korea University, Korea), JungBok Lee, Shin-Jae Lee“Statistical Tools for Protein Identification Based on Mass Spectrometry
Data: A review”
Seiya Imoto (University of Tokyo, Japan) “Bioinformatics Approach
Towards Drug Target Gene Discovery”
Masaru Ushijima (Japanese Foundation for Cancer Research) “Analyses of
OMICS Data in Medical Informatics”
Coffee BreakKeynote Lecture
Chair: Thomas Louis (Johns Hopkins Bloomberg School of Public Health,USA)
Toshiro Tango (National Institute of Public Health, Japan) “Tests for Spatial
Randomness: Detection of Disease Clustering and Outbreak Threat”
Lunch BreakInvited Session: Epidemiology
Chair: Tosiya Sato (Kyoto University School of Public Health, Japan)
Ayanendranath Basu (Indian Statistical Institute, India), Sumit Gupta,
Wen-tao Huang “Tests of Hypothesis about the Kappa Statistic based on theGoodness-of-fit Approach”

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15:00-15:30
15:30-17:00

17:30-

Satoshi Hattori (Kurume University, Japan), Takashi Yanagawa“Mantel-Haenszel Estimators for Irregular Sparse K 2 X J Tables”
Kunihiko Takahashi (National Institute of Public Health, Japan), Toshiro
Tango “Scan Statistics for Disease Clustering”
Coffee BreakContributed Session: Clinical Trials 1
Chair: Satoshi Morita (Kyoto University Hospital, Japan)
Shiro Tanaka (University of Tokyo, Japan), Yutaka Matsuyama, Yasuo
Ohashi “Estimating Surrogate Endpoints Defined by Principal Causal
Effects”
Anthony Hayter (University of Denver, USA), Chen-ju Lin “Recent
Advances in Stepdown Procedures for Identifying Inferiority Among
Treatments in Clinical Trials”
Takahiro Hasegawa (SHIONOGI & CO., LTD., Japan), Toshiro Tango“Permutation Test Following Covariate-Adaptive Randomization in
Randomized Controlled Trials”
Tetsuhisa Miwa (National Institute for Agro-Environmental Sciences, Japan)“Comparisons Between Three Treatments Including a Placebo and a Control
by the Multiple Confidence Procedure”
Conference Dinner at Capo PELLICANO

Tuesday, December 11, 2007 9:00-12:35
8:30-11:00 Conference registration
9:00-10:30

10:30-11:00
11:00-12:30

Contributed Session: Biostatistics in General
Chair: Shizue Izumi (Oita University, Japan)
Lilia L. Ramirez-Ramirez (University of Waterloo, Canada), Mary E.
Thompson “Statistical Inference for Outbreaks in a Population with aContact Network Structure”
Takashi Omori (Kyoto University School of Public Health, Japan), Takashi
Sozu, Isao Yoshimura “Several Challenges by Biostatisticians forDeveloping a New Animal Test Method”
Hyonggin An (Korea University, Korea) “Bayesian Analysis of Repeated
Data with Many Zeros: Application to the Longitudinal Adolescent
Substance Abuse Study”
Tetsushi Komori (Bayer Yakuhin, Ltd., Japan), Takashi Ohmori, Tosiya Sato
“Consistency of Signal Measures with Epidemiologic Effect Measures”
Coffee BreakContributed Session: Clinical Trails 2
Chair: Osamu Komiyama (Pfizer Japan Inc., Japan)
KyungMann Kim (University of Wisconsin-Madison, USA) “An
Independent Statistical Center in Support of the Data and Safety Monitoring
Board: The Adenoma Prevention with Celecoxib (APC) Trial”
JungBok Lee (Korea University, Korea) “An Improved Estimating Methodof QT interval for Adjusting Heart Rate: A Multivariate Approach”

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12:30-12:35

Masayuki Henmi (Institute of Statistical Mathematics, Japan), John B.
Copas, Shinto Eguchi “A Sensitivity Analysis Allowing for All Possible
Selection Processes of Studies in Meta Analysis”
Hiroyuki Uesaka (Eli Lilly Japan, Japan) “Sample Size Allocation to
Regions in a Multiregional Trial”
Closing Remarks: Tosiya Sato, Scientific Program Chair

Poster Session, December 9-10
During day
Poster Session
P01
Satoshi Teramukai (Kyoto University Hospital, Japan), Satoshi Morita“Bayesian Predictive Multi-Stage Design for Phase II Single-Arm Clinical
Trials: A Case Study”
P02
Hyo-Il Park (Chong-ju University, Korea), Soo-Duck Lim, Joong-Jae Cho“Hypothesis Test Under the Additive Hazards Model”
P03
Masahiko Gosho (Kowa Co. Ltd., Japan), Chikuma Hamada, Isao
Yoshimura “Study on the Criterion for Selecting the Working Correlation
Structure in Generalized Estimating Equation”
P04
Yumiko Uematsu (Tokyo University of Science, Japan), Chikuma Hamada,Isao Yoshimura “Statistical Method for Evaluating the Efficacy of a Drug for
Osteoporosis on the Occurrence of Bone Fractures as the Primary Endpoint”
P05
Masayuki Yamada (Tokyo University of Science, Japan), Chikuma Hamada,Isao Yoshimura “Study on the Effect of Random Effects Included in the
Analysis Model for In Vitro Pharmacological Data Adaptable to FourParameter Logistic Model”
P06
Tetsuji Tonda (Hiroshima University, Japan), Kenichi Satoh, Hiromi
Kawasaki, Takeshi Shimamoto, Teruyuki Nakayama, Kota Katanoda,
Tomotaka Sobue, Yasuto Sato, Naohito Yamaguchi, Megu Ohtaki “Statistical
Analysis of Spatial-Time Heterogeneity of Cancer Mortality Risk Based on
Growth Curve Model”
P07
Kenichi Satoh (Hiroshima University, Japan), Hirokazu Yanagihara“Modified Cp in Multivariate Ridge Regression”
P08
Keiichi Sugino (Mitsubishi Tanabe Pharma Corporation, Japan), Yasuo
Ohashi, Qian Gong “Multinational Clinical Trials in East Asia”
P09
Keiko Otani (Hiroshima University, Japan), Megu Ohtaki, Keiko Hiyama,
Kenichi Satoh, Eiso Hiyama “Two Dimensional Summarization for
Affymetrix GeneChip Probe Level Data Based on Functional States ofGene-ON/OFF”
P10
Kazue Yamaoka (National Institute of Public Health, Japan), Toshiro Tango“Effects of Lifestyle Modification on Metabolic Syndrome: Resolution Rate
and Combining Multiple Endpoints in Meta-Analysis”
P11
Mihoko Minami (Institute of Statistical Mathematics, Japan) “A New
Feature Extraction Method from very Non-Normal Data: Analysis ofMultivariate Catch and Bycatch Data by Purse-Seine Tuna Fisheries”
P12
Yukikazu Hayashi (Tokyo University of Science, Japan), Chikuma Hamada,Isao
Yoshimura“StatisticalPharmacokinetic
ModelingofControlled-Release Analgesics combining Immediate-Release andSustained-Release Components to design an appropriate Drug Delivery”

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Domestic Meeting
December 11, 2007 13:30-17:00
Biometric Seminar: Global Clinical Trials (Sponsored by Japanese Biometric Society)Contributed Paper & Poster Sessions
Oral Session
Please come to the Ichijo Hall at least 10 minutes before your session’s starting time and meetwith your chairperson, who is supposed to confirm all speakers of the session.
An LCD projector is available for presentation. Notebook computers can be connected toanalog RGB interfaces.
Instructions for Speakers in Oral Sessions• Oral presentations are scheduled so that each speaker will have at least 15 minutes.
• An LCD projector can be used. If you would like to use OHP, please contact with
EAR-BC’07 staff.
• Your own notebook computer can be connected to an LCD projector which has an analog
RGB interface (DSUB15).
• If you don’t bring a notebook computer, please contact with EAR-BC’07 staff members.
Please prepare your presentation file which can work on Microsoft PowerPoint 97-2003.

Poster Session
Posters will be on display at the lobby of the conference
venue. Posters may be mounted on the morning ofDecember 9th (at or before the coffee break). Your
poster has been assigned a specific “poster number” that
corresponds to a specific portion of a poster board.
Your poster is to be displayed for 2 days. In order to

Available Space

115cm

ensure that those who wish to discuss it with you have a
180cm

chance to do so, it is highly recommended that you be atyour poster during each of the scheduled coffee breaks.
Posters must be removed by 17:00 on December 10th.

85cm

Instructions for Presenters in Poster Session
Available space for each poster is: Width 85cm andHeight 115cm.

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Access Map
Hongo-sanchome Station.
(Subway Marunouchi Line)
8 min. walk
Hongo-sanchome Station.
(Subway Oedo Line)
6 min. walk
Yushima Station or Nezu
Station(Subway Chiyoda Line)
8 min. walkTodaimae Station.
(Subway Namboku Line)
1 min. walk
Kasuga Station.
(Subway Mita Line)
10 min. walk

Conference Dinner
Restaurant CapoPELLICANO(Med. Experimental
Research Bldg. 13F)
+81 03-5841-1527

Conference Venue
Yayoi Auditorium
Ichijo Hall
+81 3 5841 8205